Licensing in an International Market

NASA Astrophysics Data System (ADS)

Ferreira, Fernanda A.

2008-09-01

We study the effects of entry of a foreign firm on domestic welfare in the presence of licensing, when the entrant is technologically superior to the incumbent. We show that foreign entry increases domestic welfare for sufficiently large technological differences between the firms under both fixed-fee licensing and royalty licensing.

75 FR 53704 - Prospective Grant of Exclusive License: Use of Pentosan Polysulfate To Treat Certain Conditions...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-01

... the treatment of interstitial fibrosis. The current technology builds on the surprising discovery that... comments and/or application for a license which are received by the NIH Office of Technology Transfer on or... Vepa, PhD, J.D., Licensing and Patenting Manager, Office of Technology Transfer, National Institutes of...

The role of the University Licensing Office in transferring intellectual property to industry

NASA Technical Reports Server (NTRS)

Preston, John T.

1992-01-01

Universities in the US have a significant impact on business through the transfer of technology. This transfer of technology takes various forms, including faculty communications, faculty consulting activities, and the direct transfer of technology through the licensing of patents, copyrights, and other intellectual property to industry. The topics discussed include the following: background of the MIT Technology Licensing Office (TLO), goals of the MIT TLO, MIT's technology transfer philosophy, and important factors for success in new company formation.

75 FR 61220 - Massachusetts Institute of Technology: Massachusetts Institute of Technology Research Reactor...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-04

... renewed Facility Operating License No. R-37, to be held by the Massachusetts Institute of Technology (MIT... Identification of the Proposed Action The proposed action would renew Facility Operating License No. R-37 for a... License No. R-37 to allow continued operation of the MITR for a period of twenty years at an increased...

License Agreements | NCI Technology Transfer Center | TTC

Cancer.gov

NCI Technology Transfer Center (TTC) licenses the discoveries of NCI and nine other NIH Institutes so new technologies can be developed and commercialized, to convert them into public health benefits.

15 CFR 740.13 - Technology and software-unrestricted (TSU).

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Technology and software-unrestricted... REGULATIONS LICENSE EXCEPTIONS § 740.13 Technology and software—unrestricted (TSU). This license exception authorizes exports and reexports of operation technology and software; sales technology and software...

15 CFR 740.13 - Technology and software-unrestricted (TSU).

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Technology and software-unrestricted... REGULATIONS LICENSE EXCEPTIONS § 740.13 Technology and software—unrestricted (TSU). This license exception authorizes exports and reexports of operation technology and software; sales technology and software...

15 CFR 740.13 - Technology and software-unrestricted (TSU).

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Technology and software-unrestricted... REGULATIONS LICENSE EXCEPTIONS § 740.13 Technology and software—unrestricted (TSU). This license exception authorizes exports and reexports of operation technology and software; sales technology and software...

15 CFR 740.13 - Technology and software-unrestricted (TSU).

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Technology and software-unrestricted... REGULATIONS LICENSE EXCEPTIONS § 740.13 Technology and software—unrestricted (TSU). This license exception authorizes exports and reexports of operation technology and software; sales technology and software...

15 CFR 740.13 - Technology and software-unrestricted (TSU).

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Technology and software-unrestricted... REGULATIONS LICENSE EXCEPTIONS § 740.13 Technology and software—unrestricted (TSU). This license exception authorizes exports and reexports of operation technology and software; sales technology and software...

Testing licensing by cue: a case of Russian palatalized coronals.

PubMed

Kochetov, Alexei

2006-01-01

The hypothesis 'licensing by cue' by Steriade holds that phonological contrasts are maintained in environments that provide better acoustic cues to the contrasts and are neutralized in environments that provide poorer acoustic cues or no cues. This paper tests the hypothesis by examining the distribution of a phonological contrast--the Russian plain/palatalized coronal stops /t/ and /tj/ in various syllable-final contexts. The results of a series of acoustic and perceptual experiments presented in this paper provide some support for the hypothesis: the relative salience of releases in different word boundary contexts (_#k > _#n, _#s) correlates strongly with the general patterns of neutralization of the contrast in similar word-internal contexts (_k > _n, _s) in Russian and other related languages. At the same time, the relative salience of VC transitions in different vowel contexts (a_ > u_ > i_) has apparently little to do with attested patterns of neutralization. The results suggest that some perceptual cues are phonologically more relevant than others, providing evidence for interactions between phonetics and phonology more complex than predicted by the hypothesis.

Technology Transfer Center to Assume Patenting and Licensing Responsibilities | Poster

Cancer.gov

The NCI Technology Transfer Center (TTC) is undergoing a reorganization that will bring patenting and licensing responsibilities to the Shady Grove and Frederick offices by October 2015. The reorganization is a result of an effort begun in 2014 by NIH to improve the organizational structure of technology transfer at NIH to meet the rapid rate of change within science, technology, and industry, and to better align the science and laboratory goals with the licensing and patenting process.

Success factors in technology development

NASA Astrophysics Data System (ADS)

Preston, John T.

1995-01-01

Universities in the U.S. have a significant impact on business through the transfer of technology. This paper describes goals and philosophy of the Technology Licensing Office at the Massachusetts Institute of Technology. This paper also relates the critical factors for susscessful technology transfer, particularly relating to new business formation. These critical factors include the quality of the technology, the quality of the management, the quality of the investor, the passion for success, and the image of the company. Descriptions of three different levels of investment are also given and the most successful level of investment for starting a new company is reviewed. Licensing to large companies is also briefly reviewed, as this type of licensing requires some different strategies than that of licensing to start-up companies. High quality critical factors and intelligent investment create rewards for the parties and successful ventures.

77 FR 38771 - Prospective Grant of Exclusive Patent License

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-29

... DEPARTMENT OF COMMERCE National Institute of Standards and Technology Prospective Grant of Exclusive Patent License AGENCY: National Institute of Standards and Technology, Commerce. ACTION: Notice of prospective grant of exclusive patent license. SUMMARY: This is a notice in accordance with 35 U.S.C. 209(e...

From the Chemistry Lab to Licensing

NASA Technical Reports Server (NTRS)

Savino, Joseph M.; Street, Kenneth W.; Philipp, Warren H.

1998-01-01

This is a story of technology maturation and transfer, and licensing. It traces the history of the recently patented ion- exchange material (IEM) from the accidental discovery that this polymer, a battery separator of marginal performance, picked up copper from distilled water passing through corroded copper tubing in the laboratory, to a point where five organizations and one individual have applied for licenses to manufacture and market it or to use it in a wide variety of applications. This story discusses in detail the problems of converting an immature technology into a mature and eventually commercialized technology, without dedicated resources. Readers will develop an appreciation for how the obstacles to maturation and licensing of the technology were faced and overcome. The lessons learned will be discussed, with the hope of enhancing the technology transfer process.

EPA-developed, patented technologies available for licensing

EPA Pesticide Factsheets

Under the Federal Technology Transfer Act (FTTA), Federal Agencies can patent inventions developed during the course of research. These technologies can then be licensed to businesses or individuals for further development and sale in the marketplace.

Liability: the complicated task of licensing law enforcement technologies

NASA Astrophysics Data System (ADS)

Hops, Larry W.; Overlin, Trudy K.

1997-01-01

This paper discusses a situation where a company (licensor) requires a liability policy as a condition of a license agreement, when licensing law enforcement technologies. The purpose of this discussion is to evaluate the reasons behind the need for extensive liability policies to protect licensors when marketing their law enforcement technologies to private industry. Finding a solution to the problem, therefore reducing the potential for high liability insurance costs, would be desirable. Since the risks associated with most technologies are virtually unknown, and because such technologies are used in very unpredictable legal environments, alternative ways of guaranteeing research and development enterprises that they will be covered against product liability are needed. Without such protection, licensors may require licensees to indemnify them beyond the usual guarantees provided in a licensing agreement, which may make the license too costly for smaller businesses. When the share of the market is limited to larger corporations, competition suffers and ultimately the cost to law enforcement agencies increases.

15 CFR 740.7 - Computers (APP).

Code of Federal Regulations, 2010 CFR

2010-01-01

... 4A003. (2) Technology and software. License Exception APP authorizes exports of technology and software... programmability. (ii) Technology and source code. Technology and source code eligible for License Exception APP..., reexports and transfers (in-country) for nuclear, chemical, biological, or missile end-users and end-uses...

EPA-developed, patented technologies related to water monitoring and remediation that are available for licensing

EPA Pesticide Factsheets

Under the Federal Technology Transfer Act (FTTA), Federal Agencies can patent inventions developed during the course of research. These technologies can then be licensed to businesses or individuals for further development and sale in the marketplace. These technologies relate to water monitoring and treatment technologies.

15 CFR 740.17 - Encryption commodities, software and technology (ENC).

Code of Federal Regulations, 2014 CFR

2014-01-01

... technology (ENC). 740.17 Section 740.17 Commerce and Foreign Trade Regulations Relating to Commerce and... REGULATIONS LICENSE EXCEPTIONS § 740.17 Encryption commodities, software and technology (ENC). License... therefor classified under ECCN 5B002, and equivalent or related software and technology classified under...

15 CFR 740.17 - Encryption commodities, software and technology (ENC).

Code of Federal Regulations, 2013 CFR

2013-01-01

... technology (ENC). 740.17 Section 740.17 Commerce and Foreign Trade Regulations Relating to Commerce and... REGULATIONS LICENSE EXCEPTIONS § 740.17 Encryption commodities, software and technology (ENC). License... therefor classified under ECCN 5B002, and equivalent or related software and technology classified under...

15 CFR 740.17 - Encryption commodities, software and technology (ENC).

Code of Federal Regulations, 2012 CFR

2012-01-01

... technology (ENC). 740.17 Section 740.17 Commerce and Foreign Trade Regulations Relating to Commerce and... REGULATIONS LICENSE EXCEPTIONS § 740.17 Encryption commodities, software and technology (ENC). License... therefor classified under ECCN 5B002, and equivalent or related software and technology classified under...

15 CFR 740.6 - Technology and software under restriction (TSR).

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Technology and software under... REGULATIONS LICENSE EXCEPTIONS § 740.6 Technology and software under restriction (TSR). (a) Scope. License Exception TSR permits exports and reexports of technology and software where the Commerce Country Chart...

15 CFR 740.6 - Technology and software under restriction (TSR).

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Technology and software under... REGULATIONS LICENSE EXCEPTIONS § 740.6 Technology and software under restriction (TSR). (a) Scope. License Exception TSR permits exports and reexports of technology and software where the Commerce Country Chart...

15 CFR 740.6 - Technology and software under restriction (TSR).

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Technology and software under... REGULATIONS LICENSE EXCEPTIONS § 740.6 Technology and software under restriction (TSR). (a) Scope. License Exception TSR permits exports and reexports of technology and software where the Commerce Country Chart...

15 CFR 740.6 - Technology and software under restriction (TSR).

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Technology and software under... REGULATIONS LICENSE EXCEPTIONS § 740.6 Technology and software under restriction (TSR). (a) Scope. License Exception TSR permits exports and reexports of technology and software where the Commerce Country Chart...

EPA-developed, patented technologies related to waste that are available for licensing

EPA Pesticide Factsheets

Under the Federal Technology Transfer Act (FTTA), Federal Agencies can patent inventions developed during the course of research. These technologies can then be licensed to businesses or individuals for further development and sale in the marketplace. These technologies relate to methods of managing and remediating waste.

EPA-developed, patented technologies related to air quality that are available for licensing

EPA Pesticide Factsheets

Under the Federal Technology Transfer Act (FTTA), Federal Agencies can patent inventions developed during the course of research. These technologies can then be licensed to businesses or individuals for further development and sale in the marketplace. These technologies relate to monitoring and sampling air quality.

EPA-developed, patented technologies related to pollution prevention that are available for licensing.

EPA Pesticide Factsheets

Under the Federal Technology Transfer Act (FTTA), Federal Agencies can patent inventions developed during the course of research. These technologies can then be licensed to businesses or individuals for further development and sale in the marketplace. These technologies primarily relate to contaminant removal in the environment.

15 CFR 740.6 - Technology and software under restriction (TSR).

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Technology and software under... REGULATIONS LICENSE EXCEPTIONS § 740.6 Technology and software under restriction (TSR). (a) Scope. License Exception TSR permits exports and reexports of technology and software where the Commerce Country Chart...

77 FR 14508 - Notice of Intent To Grant Exclusive Patent License; MHM Technologies, LLC

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-12

... DEPARTMENT OF DEFENSE Department of the Navy Notice of Intent To Grant Exclusive Patent License... the Navy hereby gives notice of its intent to grant to MHM Technologies, LLC a revocable, nonassignable, exclusive license to practice in the United States, the Government-owned invention described in U...

78 FR 57868 - Prospective Grant of Exclusive Patent License: Oral Treatment of Hemophilia

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-20

... Exclusive Patent License to ProGenetics, LLC, a company having its headquarters in Blacksburg, Virginia, to... comments and/or applications for a license received by the NIH Office of Technology Transfer on or before...: Vince Contreras, Ph.D., Office of Technology Transfer, National Institutes of Health, 6011 Executive...

Welfare Effects of Entry into International Markets with Licensing

NASA Astrophysics Data System (ADS)

Ferreira, F. A.; Ferreira, Fl.

2008-10-01

We study the effects of entry of a foreign firm on domestic welfare in the presence of licensing, when the entrant is technologically inferior to the incumbent. We show that foreign entry increases domestic welfare for intermediate (respectively, sufficiently large) technological differences between the firms under licensing with fixed fee (respectively, output royalty).

FTTA Hightlighted Patents

EPA Pesticide Factsheets

This page highlights patented EPA-developed technologies that are available for licensing. FTTA staff contacts (link) can provide more information on any of these technologies, as well as information on licensing.

Better Demand Signal, Better Decisions? Evaluation of Big Data in a Licensed Remanufacturing Supply Chain with Environmental Risk Considerations.

PubMed

Niu, Baozhuang; Zou, Zongbao

2017-08-01

Big data ability helps obtain more accurate demand signal. However, is better demand signal always beneficial for the supply chain parties? To answer this question, we investigate a remanufacturing supply chain (RSC), where demand uncertainty is significant, and the value to reduce environmental risk is large. Specifically, we focus on a licensed RSC comprising an original equipment manufacturer (OEM) and a third-party remanufacturer (3PR). The latter pays a unit license fee to the former, and can be risk averse to the demand of remanufactured products. We show that the OEM and the risk-neutral 3PR always have incentives to improve their big data abilities to increase their profits. However, when the 3PR is risk averse, big data might hurt its profit: the value of big data is positive if its demand signal accuracy is sufficiently low. Interestingly, we find that while information sharing hurts the 3PR, it benefits the OEM as well as the supply chain. Thus, if costly information sharing is allowed, a win-win situation can be achieved. We also find that information sharing generates more valuation when the 3PR is risk averse than that when the 3PR is risk neutral. More importantly, we find that the 3PR's risk attitude and demand signal accuracy can significantly mitigate the negative environmental impact (measured by the amount of the waste): (1) the more risk neutral the 3PR is, the better the environment is; (2) the more accurate demand signal is, the better the environment is. © 2017 Society for Risk Analysis.

EPA-developed, patented technologies related to contaminated sites and hazardous substances that are available for licensing

EPA Pesticide Factsheets

Under the Federal Technology Transfer Act (FTTA), Federal Agencies can patent inventions developed during the course of research. These technologies can then be licensed to businesses or individuals for further development and sale in the marketplace. These technologies relate to treatment of contaminated sites.

Technology Licensing for the Benefit of the Developing World: UC Berkeley's Socially Responsible Licensing Program

ERIC Educational Resources Information Center

Mimura, Carol

2007-01-01

In the years since the passage of the Bayh-Dole Act of 1980, university technology transfer success has been measured primarily by traditional metrics such as numbers of patents filed, revenue obtained from licensed patents and numbers of start-up companies founded to commercialize university intellectual property. Intellectual property (IP)…

15 CFR 970.402 - Technological capability.

Code of Federal Regulations, 2010 CFR

2010-01-01

... ENVIRONMENTAL DATA SERVICE DEEP SEABED MINING REGULATIONS FOR EXPLORATION LICENSES Certification of Applications... possess or have access to, at the time of issuance or transfer of the license, the technology and...

NASA Johnson Space Center Medical Licensing Opportunities

NASA Technical Reports Server (NTRS)

Hernandez-Moya, Sonia

2009-01-01

This presentation reviews patented medical items that are available for licensing in the areas of Laboratory Technologies, Medical Devices, Medical Equipment and other technologies that are of interest to the medical community.

EPA-developed, patented technologies related to miscellaneous areas of environmental experties and invention that are available for licensing

EPA Pesticide Factsheets

Under the Federal Technology Transfer Act (FTTA), Federal Agencies can patent inventions developed during the course of research. These technologies can then be licensed to businesses or individuals for further development and sale in the marketplace. These technologies relate to ecological research, human health, and manufacturing.

License plate recognition.

DOT National Transportation Integrated Search

2008-01-01

License Plate Recognition (LPR) technology has been used for off-line automobile enforcement purposes. The technology has seen mixed success with correct reading rate around 60 to 70% depending on the specific application and environment. This limita...

77 FR 73456 - Notice of Intent To Grant Exclusive Patent License; Fiber Optic Sensor Systems Technology...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-10

...; Fiber Optic Sensor Systems Technology Corporation AGENCY: Department of the Navy, DoD. ACTION: Notice... Systems Technology Corporation a revocable, nonassignable, exclusive license to practice the field of use of electrical power measurements for the measurement or control of temperature, pressure, strain...

75 FR 34988 - Notice of Intent To Grant Exclusive Patent License; Fiber Optic Sensor Systems Technology...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-21

...; Fiber Optic Sensor Systems Technology Corporation AGENCY: Department of the Navy, DoD. ACTION: Notice... Systems Technology Corporation a revocable, nonassignable, exclusive license to practice the field of use of electrical power measurements for the measurement or control of temperature, pressure, strain...

Innovative Technology Reduces Power Plant Emissions - Commercialization Success

NASA Technical Reports Server (NTRS)

Parrish, Clyde

2004-01-01

Emission control system development includes: (1) Development of new oxidizer scrubber system to eliminate NOx waste and produce fertilizer (2) Technology licensed and a 1 to 3 MWatt-scale prototype installed on. power plant (3) Development of method to oxidize NO. to N02 (4) Experience gained from licensing NASA technology

15 CFR 742.5 - Missile technology.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Missile technology. 742.5 Section 742... BASED CONTROLS § 742.5 Missile technology. (a) License requirements. (1) In support of U.S. foreign policy to limit the proliferation of missiles, a license is required to export and reexport items related...

15 CFR 742.5 - Missile technology.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Missile technology. 742.5 Section 742... BASED CONTROLS § 742.5 Missile technology. (a) License requirements. (1) In support of U.S. foreign policy to limit the proliferation of missiles, a license is required to export and reexport items related...

15 CFR 742.5 - Missile technology.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Missile technology. 742.5 Section 742... BASED CONTROLS § 742.5 Missile technology. (a) License requirements. (1) In support of U.S. foreign policy to limit the proliferation of missiles, a license is required to export and reexport items related...

77 FR 38772 - Prospective Grant of Exclusive Patent License

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-29

... DEPARTMENT OF COMMERCE National Institute of Standards and Technology Prospective Grant of Exclusive Patent License AGENCY: National Institute of Standards and Technology, Department of Commerce... with 35 U.S.C. 209(e) and 37 CFR 404.7(a)(1)(i) that the National Institute of Standards and Technology...

77 FR 20823 - Prospective Grant of Exclusive License: Family Healthware

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-06

... Grant of Exclusive License: Family Healthware AGENCY: Technology Transfer Office, Centers for Disease... and Prevention (CDC), Technology Transfer Office, Department of Health and Human Services (DHHS), is... priority to Provisional Patent Application No. 60/650,076, filed 2/3/2005. CDC Technology ID No. I- 004-04...

Complexity of Human Antibody Response to Dengue Virus: Implication for Vaccine Development.

PubMed

Tsai, Wen-Yang; Lin, Hong-En; Wang, Wei-Kung

2017-01-01

The four serotypes of dengue virus (DENV) are the leading cause of arboviral diseases in humans. Decades of efforts have made remarkable progress in dengue vaccine development. Despite the first dengue vaccine (dengvaxia from Sanofi Pasteur), a live-attenuated tetravalent chimeric yellow fever-dengue vaccine, has been licensed by several countries since 2016, its overall moderate efficacy (56.5-60.8%) in the presence of neutralizing antibodies during the Phase 2b and 3 trials, lower efficacy among dengue naïve compared with dengue experienced individuals, and increased risk of hospitalization among young children during the follow-up highlight the need for a better understanding of humoral responses after natural DENV infection. Recent studies of more than 300 human monoclonal antibodies (mAbs) against DENV have led to the discovery of several novel epitopes on the envelope protein recognized by potent neutralizing mAbs. This information together with in-depth studies on polyclonal sera and B-cells following natural DENV infection has tremendous implications for better immunogen design for a safe and effective dengue vaccine. This review outlines the progress in our understanding of mouse mAbs, human mAbs, and polyclonal sera against DENV envelope and precursor membrane proteins, two surface proteins involved in vaccine development, following natural infection; analyses of these discoveries have provided valuable insight into new strategies involving molecular technology to induce more potent neutralizing antibodies and less enhancing antibodies for next-generation dengue vaccine development.

Complexity of Human Antibody Response to Dengue Virus: Implication for Vaccine Development

PubMed Central

Tsai, Wen-Yang; Lin, Hong-En; Wang, Wei-Kung

2017-01-01

The four serotypes of dengue virus (DENV) are the leading cause of arboviral diseases in humans. Decades of efforts have made remarkable progress in dengue vaccine development. Despite the first dengue vaccine (dengvaxia from Sanofi Pasteur), a live-attenuated tetravalent chimeric yellow fever-dengue vaccine, has been licensed by several countries since 2016, its overall moderate efficacy (56.5–60.8%) in the presence of neutralizing antibodies during the Phase 2b and 3 trials, lower efficacy among dengue naïve compared with dengue experienced individuals, and increased risk of hospitalization among young children during the follow-up highlight the need for a better understanding of humoral responses after natural DENV infection. Recent studies of more than 300 human monoclonal antibodies (mAbs) against DENV have led to the discovery of several novel epitopes on the envelope protein recognized by potent neutralizing mAbs. This information together with in-depth studies on polyclonal sera and B-cells following natural DENV infection has tremendous implications for better immunogen design for a safe and effective dengue vaccine. This review outlines the progress in our understanding of mouse mAbs, human mAbs, and polyclonal sera against DENV envelope and precursor membrane proteins, two surface proteins involved in vaccine development, following natural infection; analyses of these discoveries have provided valuable insight into new strategies involving molecular technology to induce more potent neutralizing antibodies and less enhancing antibodies for next-generation dengue vaccine development. PMID:28775720

Maximizing profits in international technology transfer

NASA Technical Reports Server (NTRS)

Straube, W.

1974-01-01

Maximum profit can be introduced into international technology transfer by observing the following: (1) ethical and open dealing between the parties; (2) maximum knowledge of all facts concerning the technology, the use of the technology, the market, competition, prices, and alternatives; (3) ability to coordinate exports, service, support activities, licensing and cross licensing; and (4) knowledgeable people which put these factors together.

Issues to Consider before Licensing Technology to a Start-Up: Mitigating Risk with Early Planning for the Entire Business Cycle

ERIC Educational Resources Information Center

LaBarge, Jeffrey H.

2005-01-01

If done correctly, licensing technology to a start-up company provides a great opportunity for a university to commercialize its technology and generate good will. If done incorrectly, however, the venture may jeopardize the technology's value and adversely affect the university's reputation within the business and academic communities. Before…

15 CFR 740.17 - Encryption commodities, software and technology (ENC).

Code of Federal Regulations, 2010 CFR

2010-01-01

... technology (ENC). 740.17 Section 740.17 Commerce and Foreign Trade Regulations Relating to Commerce and... REGULATIONS LICENSE EXCEPTIONS § 740.17 Encryption commodities, software and technology (ENC). License... classified under ECCNs 5A002.a.1, a.2, a.5, a.6 or a.9, 5B002, 5D002, and technology that is classified under...

78 FR 29435 - Proposed Information Collection (Availability of Educational, Licensing, and Certifications...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-20

... techniques or the use of other forms of information technology. Title: Availability of Educational, Licensing... (Availability of Educational, Licensing, and Certifications Records) Activity: Comment Request AGENCY: Veterans... to determine whether payments provided to educational institutions and licensing and certification...

Values in the Net Neutrality Debate: Applying Content Analysis to Testimonies from Public Hearings

ERIC Educational Resources Information Center

Cheng, An-Shou

2012-01-01

The Net neutrality debate is an important telecommunications policy issue that closely tied to technological innovation, economic development, and information access. Existing studies on Net neutrality have focused primarily on technological requirements, economic analysis, and regulatory justifications. Since values, technology, and policy are…

License plate recognition (phase B).

DOT National Transportation Integrated Search

2010-06-01

License Plate Recognition (LPR) technology has been used for off-line automobile enforcement purposes. The technology has seen mixed success with correct reading rate as high as 60 to 80% depending on the specific application and environment. This li...

Innovative Technology Reduces Power Plant Emissions-Commercialization Success

NASA Technical Reports Server (NTRS)

Parrish, Clyde; Chung, Landy

2004-01-01

Overview of emission control system development: (1) Development of new oxidizer scrubber system to eliminate NOx waste and produce fertilizer (2) Technology licensed and a 1 to 3 MWatt-scale prototype installed on power plant (3) Development of method to oxidize NO to NO2 (4) Experience gained from licensing NASA technology.

37 CFR 5.20 - Export of technical data relating to sensitive nuclear technology.

Code of Federal Regulations, 2011 CFR

2011-07-01

... relating to sensitive nuclear technology. 5.20 Section 5.20 Patents, Trademarks, and Copyrights UNITED... LICENSES TO EXPORT AND FILE APPLICATIONS IN FOREIGN COUNTRIES Licenses for Foreign Exporting and Filing § 5.20 Export of technical data relating to sensitive nuclear technology. Under regulations (10 CFR 810.7...

37 CFR 5.20 - Export of technical data relating to sensitive nuclear technology.

Code of Federal Regulations, 2010 CFR

2010-07-01

... relating to sensitive nuclear technology. 5.20 Section 5.20 Patents, Trademarks, and Copyrights UNITED... LICENSES TO EXPORT AND FILE APPLICATIONS IN FOREIGN COUNTRIES Licenses for Foreign Exporting and Filing § 5.20 Export of technical data relating to sensitive nuclear technology. Under regulations (10 CFR 810.7...

6 CFR 37.19 - Machine readable technology on the driver's license or identification card.

Code of Federal Regulations, 2011 CFR

2011-01-01

..., States must use the ISO/IEC 15438:2006(E) Information Technology—Automatic identification and data... 6 Domestic Security 1 2011-01-01 2011-01-01 false Machine readable technology on the driver's..., Verification, and Card Issuance Requirements § 37.19 Machine readable technology on the driver's license or...

6 CFR 37.19 - Machine readable technology on the driver's license or identification card.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., States must use the ISO/IEC 15438:2006(E) Information Technology—Automatic identification and data... 6 Domestic Security 1 2010-01-01 2010-01-01 false Machine readable technology on the driver's..., Verification, and Card Issuance Requirements § 37.19 Machine readable technology on the driver's license or...

NRC Licensing Status Summary Report for NGNP

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moe, Wayne Leland; Kinsey, James Carl

2014-11-01

The Next Generation Nuclear Plant (NGNP) Project, initiated at Idaho National Laboratory (INL) by the U.S. Department of Energy (DOE) pursuant to provisions of the Energy Policy Act of 2005, is based on research and development activities supported by the Department of Energy Generation IV Nuclear Energy Systems Initiative. The principal objective of the NGNP Project is to support commercialization of high temperature gas-cooled reactor (HTGR) technology. The HTGR is a helium-cooled and graphite moderated reactor that can operate at temperatures much higher than those of conventional light water reactor (LWR) technologies. The NGNP will be licensed for construction andmore » operation by the Nuclear Regulatory Commission (NRC). However, not all elements of current regulations (and their related implementation guidance) can be applied to HTGR technology at this time. Certain policies established during past LWR licensing actions must be realigned to properly accommodate advanced HTGR technology. A strategy for licensing HTGR technology was developed and executed through the cooperative effort of DOE and the NRC through the NGNP Project. The purpose of this report is to provide a snapshot of the current status of the still evolving pre-license application regulatory framework relative to commercial HTGR technology deployment in the U.S. The following discussion focuses on (1) describing what has been accomplished by the NGNP Project up to the time of this report, and (2) providing observations and recommendations concerning actions that remain to be accomplished to enable the safe and timely licensing of a commercial HTGR facility in the U.S.« less

14 CFR 1274.915 - Restrictions on sale or transfer of technology to foreign firms or institutions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... licensing of the technology. Transfers include: (1) Sales of products or components, (2) Licenses of software or documentation related to sales of products or components, or (3) Transfers to foreign...

14 CFR § 1274.915 - Restrictions on sale or transfer of technology to foreign firms or institutions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... licensing of the technology. Transfers include: (1) Sales of products or components, (2) Licenses of software or documentation related to sales of products or components, or (3) Transfers to foreign...

14 CFR 1274.915 - Restrictions on sale or transfer of technology to foreign firms or institutions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... licensing of the technology. Transfers include: (1) Sales of products or components, (2) Licenses of software or documentation related to sales of products or components, or (3) Transfers to foreign...

76 FR 23819 - Prospective Granting of an Exclusive License

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-28

... contemplating granting a worldwide exclusive license to AES Raptor, LLC, located in North Kansas City, Missouri. Under this exclusive license, only AES Raptor, LLC would be permitted to commercialize the technology...

Samsung Licenses ORNL Transparent Superhydrophobic Glass Coating Technology for Electronic Devices

ScienceCinema

Aytug, Tolga

2018-06-12

Samsung Electronics has exclusively licensed optically clear superhydrophobic film technology from the Department of Energy’s Oak Ridge National Laboratory to improve the performance of glass displays on smartphones, tablets and other electronic devices.

Critical Technology Assessment: Fine Grain, High Density Graphite

DTIC Science & Technology

2010-04-01

Control Classification Number ( ECCN ) 1C107.a on the Commerce Control List (CCL). The parameters of 1C107.a stem from controls established by the Missile...Technology Control Regime (MTCR). In this assessment, BIS specifically examined: • The application of ECCN 1C107.a and related licensing...export licensing process for fine grain, high density graphite controlled by ECCN 1C107.a, especially to China, requires more license conditions and

When technologies makes good people do bad things: another argument against the value-neutrality of technologies.

PubMed

Morrow, David R

2014-06-01

Although many scientists and engineers insist that technologies are value-neutral, philosophers of technology have long argued that they are wrong. In this paper, I introduce a new argument against the claim that technologies are value-neutral. This argument complements and extends, rather than replaces, existing arguments against value-neutrality. I formulate the Value-Neutrality Thesis, roughly, as the claim that a technological innovation can have bad effects, on balance, only if its users have "vicious" or condemnable preferences. After sketching a microeconomic model for explaining or predicting a technology's impact on individuals' behavior, I argue that a particular technological innovation can create or exacerbate collective action problems, even in the absence of vicious preferences. Technologies do this by increasing the net utility of refusing to cooperate. I also argue that a particular technological innovation can induce short-sighted behavior because of humans' tendency to discount future benefits too steeply. I suggest some possible extensions of my microeconomic model of technological impacts. These extensions would enable philosophers of technology to consider agents with mixed motives-i.e., agents who harbor some vicious preferences but also some aversion to acting on them-and to apply the model to questions about the professional responsibilities of engineers, scientists, and other inventors.

Wave Making Resistance Characteristics of Trimaran Hulls

DTIC Science & Technology

2003-12-01

to increased emphasis on warships that can neutralize anti-access measures such as minefields, quiet diesel- electric submarines and swarms of small...package licensed by AMTEC Engineering. The reference coordinate system illustrated in Figure 3 and used by SWAN-2 must be selected such that the 0z

Technology-neutral green procurement in practice - an example from Swedish waste management.

PubMed

Arvidsson, Anders; Stage, Jesper

2012-05-01

Green public procurement has been criticized for its excessive reliance on detailed technology specifications, which can distort incentives in the short term and discourage innovation in the longer term. Economists therefore tend to prefer technology-neutral procurement, which rewards outcomes rather than technologies. However, technology-neutral procurement can also be problematic in practice. The present study investigated green public procurement of waste management, a rapidly growing field. In one of the most sophisticated models for technology-neutral procurement applied in Sweden in recent years, different environmental impacts were assigned weights, but no weight was given to the particular technology employed. Even here, however, potential inefficiencies were found where the scoring rule could have led to arbitrary, and presumably unwanted, outcomes. Explicitly assigning monetary surcharges to desirable and undesirable environmental effects may be a better way to reach environmental targets.

Microsoft Biology Initiative: .NET Bioinformatics Platform and Tools

PubMed Central

Diaz Acosta, B.

2011-01-01

The Microsoft Biology Initiative (MBI) is an effort in Microsoft Research to bring new technology and tools to the area of bioinformatics and biology. This initiative is comprised of two primary components, the Microsoft Biology Foundation (MBF) and the Microsoft Biology Tools (MBT). MBF is a language-neutral bioinformatics toolkit built as an extension to the Microsoft .NET Framework—initially aimed at the area of Genomics research. Currently, it implements a range of parsers for common bioinformatics file formats; a range of algorithms for manipulating DNA, RNA, and protein sequences; and a set of connectors to biological web services such as NCBI BLAST. MBF is available under an open source license, and executables, source code, demo applications, documentation and training materials are freely downloadable from http://research.microsoft.com/bio. MBT is a collection of tools that enable biology and bioinformatics researchers to be more productive in making scientific discoveries.

Technology Transfer Center to Assume Patenting and Licensing Responsibilities | Poster

Cancer.gov

The NCI Technology Transfer Center (TTC) is undergoing a reorganization that will bring patenting and licensing responsibilities to the Shady Grove and Frederick offices by October 2015. The reorganization is a result of an effort begun in 2014 by NIH to improve the organizational structure of technology transfer at NIH to meet the rapid rate of change within science,

Fluorescence techniques in agricultural applications

NASA Astrophysics Data System (ADS)

McMurtrey, James E.; Corp, Lawrence A.; Kim, Moon S.; Chappelle, Emmett W.; Daughtry, Craig S. T.; DiBenedetto, J. D.

2001-03-01

Intellectual property licensing is an important issue facing all technology companies. Before entering into license agreements a number of issues need to be addressed, including invention ownership, obtaining and identifying licensable subject matter, and developing a licensing strategy. There are a number of important provisions that are included in most intellectual property license agreements. These provisions include definitions, the license grant, consideration, audit rights, confidentiality, warranties, indemnification, and limitation of liability. Special licensing considerations exist relative to each type of intellectual property, and when the other party is a foreign company or a university.

Veterinary Medicine and Animal Health Technology Handbook.

ERIC Educational Resources Information Center

New York State Education Dept., Albany. Office of the Professions.

The laws, rules, and regulations of the New York State Education Department that govern professional veterinary medicine and animal health technology practice in the state are presented. Licensure requirements are described, and complete application forms and instructions for obtaining license and first registration as a licensed veterinarian and…

Surveying the Need for Technology Management for Global Health Training Programmes

ERIC Educational Resources Information Center

Balakrishnan, Usha R.; Troyer, Lisa; Brands, Edwin

2007-01-01

Technology licensing office managers often need to evaluate profitability and commercial potential in their decision making. However, increased consideration of important global public health goals requires forging new collaborative relationships, incorporating creative licensing practices and embracing global public good within the academic and…

31 CFR 500.533 - Exportations, reexportations, and incidental transactions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... CONTROL REGULATIONS Licenses, Authorizations and Statements of Licensing Policy § 500.533 Exportations..., software, or technology (including technical data) from the United States or reexportation of U.S.-origin goods, software, or technology from a foreign country to any person in a designated foreign country or...

Persian Gulf: U.S. Agencies Need to Improve Licensing Data and to Document Reviews of Arms Transfers for U.S. Foreign Policy and National Security Goals

DTIC Science & Technology

2010-09-01

of Defense DTSA Defense Technology Security Administration FMS Foreign Military Sales GSD Gulf Security Dialogue LOA Letter of Offer and...may refer license applications to the Defense Technology Security Administration ( DTSA ) to determine if the United States should release the...requested technology to the requesting foreign government. Specifically, DTSA assesses the sale’s impact on preserving critical U.S. military technological

78 FR 63959 - Notice of Intent To Grant Exclusive License

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-25

... Research Service, intends to grant to EPG Technologies, Inc. of Gainesville, Florida, an exclusive license to U.S. Patent No. 8,004,292, ``ELECTRICAL PENETRATION GRAPH SYSTEM,'' issued on August 23, 2011..., Office of Technology Transfer, 5601 Sunnyside Avenue, Rm. 4-1174, Beltsville, Maryland 20705-5131. FOR...

15 CFR 750.3 - Review of license applications by BIS and other government agencies and departments.

Code of Federal Regulations, 2010 CFR

2010-01-01

... items controlled for national security, missile technology, nuclear nonproliferation, and chemical and... primarily with items controlled for national security, nuclear nonproliferation, missile technology... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Review of license applications by BIS...

15 CFR 750.3 - Review of license applications by BIS and other government agencies and departments.

Code of Federal Regulations, 2011 CFR

2011-01-01

... items controlled for national security, missile technology, nuclear nonproliferation, and chemical and... primarily with items controlled for national security, nuclear nonproliferation, missile technology... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Review of license applications by BIS...

Social Construction of Authorized Users in the Digital Age

ERIC Educational Resources Information Center

Zhu, Xiaohua; Eschenfelder, Kristin R.

2010-01-01

This paper analyzes changes to the definitions of "authorized users" contained in electronic resources licenses and embedded in access control technologies from the mid-1990s to the present. In analyzing changes to the license and technology-based definitions, it tracks shifts in major stakeholders' perceptions of authorized users and…

77 FR 21573 - Government-Owned Inventions; Availability for Licensing

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-10

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing AGENCY: National Institutes of Health, Public Health Service, HHS. ACTION: Notice... the indicated licensing contact at the Office of Technology Transfer, National Institutes of Health...

76 FR 13193 - Government-Owned Inventions; Availability for Licensing

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-10

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing AGENCY: National Institutes of Health, Public Health Service, HHS. ACTION: Notice... the indicated licensing contact at the Office of Technology Transfer, National Institutes of Health...

31 CFR 538.507 - Reexports by non-U.S. persons.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY SUDANESE SANCTIONS REGULATIONS Licenses... technology subject to export license application requirements under other United States regulations. The... the United States, the exportation of which to Sudan is subject to export or reexport license...

37 CFR 404.8 - Application for a license.

Code of Federal Regulations, 2010 CFR

2010-07-01

... being practiced by private industry or Government, or both, or is otherwise available commercially; and.... 404.8 Section 404.8 Patents, Trademarks, and Copyrights ASSISTANT SECRETARY FOR TECHNOLOGY POLICY, DEPARTMENT OF COMMERCE LICENSING OF GOVERNMENT OWNED INVENTIONS § 404.8 Application for a license. An...

37 CFR 404.8 - Application for a license.

Code of Federal Regulations, 2011 CFR

2011-07-01

... being practiced by private industry or Government, or both, or is otherwise available commercially; and.... 404.8 Section 404.8 Patents, Trademarks, and Copyrights ASSISTANT SECRETARY FOR TECHNOLOGY POLICY, DEPARTMENT OF COMMERCE LICENSING OF GOVERNMENT OWNED INVENTIONS § 404.8 Application for a license. An...

License Compliance Issues For Biopharmaceuticals: Special Challenges For Negotiations Between Companies And Non-Profit Research Institutions.

PubMed

Ponzio, Todd A; Feindt, Hans; Ferguson, Steven

2011-09-01

Biopharmaceuticals are therapeutic products based on biotechnology. They are manufactured by or from living organisms and are the most complex of all commercial medicines to develop, manufacture and qualify for regulatory approval. In recent years biopharmaceuticals have rapidly increased in number and importance with over 400() already marketed in the U.S. and European markets alone. Many companies throughout the world are now ramping up investments in biopharmaceutical R&D and expanding their portfolios through licensing of early-stage biotechnologies from universities and other non-profit research institutions, and there is an increasing number of license agreements for biopharmaceutical product development relative to traditional small molecule drug compounds. This trend will only continue as large numbers of biosimilars and biogenerics enter the market.A primary goal of technology transfer offices associated with publicly-funded, non-profit research institutions is to establish patent protection for inventions deemed to have commercial potential and license them for product development. Such licenses help stimulate economic development and job creation, bring a stream of royalty revenue to the institution and, hopefully, advance the public good or public health by bringing new and useful products to market. In the course of applying for such licenses, a commercial development plan is usually put forth by the license applicant. This plan indicates the path the applicant expects to follow to bring the licensed invention to market. In the case of small molecule drug compounds, there exists a widely-recognized series of clinical development steps, dictated by regulatory requirements, that must be met to bring a new drug to market, such as completion of preclinical toxicology, Phase 1, 2 and 3 testing and product approvals. These steps often become the milestone/benchmark schedule incorporated into license agreements which technology transfer offices use to monitor the licensee's diligence and progress; most exclusive licenses include a commercial development plan, with penalties, financial or even revocation of the license, if the plan is not followed, e.g., the license falls too far behind.This study examines whether developmental milestone schedules based on a small molecule drug development model are useful and realistic in setting expectations for biopharmaceutical product development. We reviewed the monitoring records of all exclusive Public Health Service (PHS) commercial development license agreements for small molecule drugs or therapeutics based on biotechnology (biopharmaceuticals) executed by the National Institutes of Health (NIH) Office of Technology Transfer (OTT) between 2003 and 2009. We found that most biopharmaceutical development license agreements required amending because developmental milestones in the negotiated schedule could not be met by the licensee. This was in stark contrast with license agreements for small molecule chemical compounds which rarely needed changes to their developmental milestone schedules. As commercial development licenses for biopharmaceuticals make up the vast majority of NIH's exclusive license agreements, there is clearly a need to: 1) more closely examine how these benchmark schedules are formed, 2) try to understand the particular risk factors contributing to benchmark schedule non-compliance, and 3) devise alternatives to the current license benchmark schedule structural model. Schedules that properly weigh the most relevant risk factors such as technology classification (e.g., vaccine vs recombinant antibody vs gene therapy), likelihood of unforeseen regulatory issues, and company size/structure may help assure compliance with original license benchmark schedules. This understanding, coupled with a modified approach to the license negotiation process that makes use of a clear and comprehensive term sheet to minimize ambiguities should result in a more realistic benchmark schedule.

License Compliance Issues For Biopharmaceuticals: Special Challenges For Negotiations Between Companies And Non-Profit Research Institutions

PubMed Central

Ponzio, Todd A.; Feindt, Hans; Ferguson, Steven

2011-01-01

Summary Biopharmaceuticals are therapeutic products based on biotechnology. They are manufactured by or from living organisms and are the most complex of all commercial medicines to develop, manufacture and qualify for regulatory approval. In recent years biopharmaceuticals have rapidly increased in number and importance with over 4001 already marketed in the U.S. and European markets alone. Many companies throughout the world are now ramping up investments in biopharmaceutical R&D and expanding their portfolios through licensing of early-stage biotechnologies from universities and other non-profit research institutions, and there is an increasing number of license agreements for biopharmaceutical product development relative to traditional small molecule drug compounds. This trend will only continue as large numbers of biosimilars and biogenerics enter the market. A primary goal of technology transfer offices associated with publicly-funded, non-profit research institutions is to establish patent protection for inventions deemed to have commercial potential and license them for product development. Such licenses help stimulate economic development and job creation, bring a stream of royalty revenue to the institution and, hopefully, advance the public good or public health by bringing new and useful products to market. In the course of applying for such licenses, a commercial development plan is usually put forth by the license applicant. This plan indicates the path the applicant expects to follow to bring the licensed invention to market. In the case of small molecule drug compounds, there exists a widely-recognized series of clinical development steps, dictated by regulatory requirements, that must be met to bring a new drug to market, such as completion of preclinical toxicology, Phase 1, 2 and 3 testing and product approvals. These steps often become the milestone/benchmark schedule incorporated into license agreements which technology transfer offices use to monitor the licensee’s diligence and progress; most exclusive licenses include a commercial development plan, with penalties, financial or even revocation of the license, if the plan is not followed, e.g., the license falls too far behind. This study examines whether developmental milestone schedules based on a small molecule drug development model are useful and realistic in setting expectations for biopharmaceutical product development. We reviewed the monitoring records of all exclusive Public Health Service (PHS) commercial development license agreements for small molecule drugs or therapeutics based on biotechnology (biopharmaceuticals) executed by the National Institutes of Health (NIH) Office of Technology Transfer (OTT) between 2003 and 2009. We found that most biopharmaceutical development license agreements required amending because developmental milestones in the negotiated schedule could not be met by the licensee. This was in stark contrast with license agreements for small molecule chemical compounds which rarely needed changes to their developmental milestone schedules. As commercial development licenses for biopharmaceuticals make up the vast majority of NIH’s exclusive license agreements, there is clearly a need to: 1) more closely examine how these benchmark schedules are formed, 2) try to understand the particular risk factors contributing to benchmark schedule non-compliance, and 3) devise alternatives to the current license benchmark schedule structural model. Schedules that properly weigh the most relevant risk factors such as technology classification (e.g., vaccine vs recombinant antibody vs gene therapy), likelihood of unforeseen regulatory issues, and company size/structure may help assure compliance with original license benchmark schedules. This understanding, coupled with a modified approach to the license negotiation process that makes use of a clear and comprehensive term sheet to minimize ambiguities should result in a more realistic benchmark schedule. PMID:22162900

Tort Liability That May Attach to Intellectual Property Licensing.

ERIC Educational Resources Information Center

Norris, William R.

1979-01-01

Examined are elements that complicate the relationship between tort law and intellectual property licensing (patents): governmental regulation of products, legal standards, the evolution of tort doctrine, international law and practice, trademark, technology and patent licensing. Available from P.O. Box 2600, Arlington, VA 22202. (MSE)

Advanced planning surveys using automatic license plate reading equipment and evaluation of automatic license plate reading equipment for advanced planning

DOT National Transportation Integrated Search

1998-05-01

Recent technological advances in computer hardware, software, and image processing have led to the development of automated license plate reading equipment. This equipment has primarily been developed for enforcement and security applications, such a...

If It's Neutral, It's Not Technology

ERIC Educational Resources Information Center

Strate, Lance

2012-01-01

Taking a media ecology perspective, this article argues that technology cannot be neutral, because it is a form of change, and it has an inherent bias based on the properties of its materials and methods. Additionally, the application of a technology is an intrinsic part of the technology itself, as is technique, instructions, software, or…

75 FR 36481 - Encryption Export Controls: Revision of License Exception ENC and Mass Market Eligibility...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-25

... Eligibility for Most Encryption Technology, to Non-``Government End-Users'' Outside Country Group D:1 or E:1.... Encryption Export Controls: Revision of License Exception ENC and Mass Market Eligibility, Submission... Export Controls: Revision of License Exception ENC and Mass Market Eligibility, Submission Procedures...

15 CFR 750.7 - Issuance of licenses.

Code of Federal Regulations, 2010 CFR

2010-01-01

.... After a license application is approved, a computer generated license is issued by the Department of... technology, commodities will be approved with a quantity or dollar value limit. The “Unit” paragraph within... is related to a multi-year project, when production lead time will not permit an export or reexport...

75 FR 80730 - Francis Slakey on Behalf of the American Physical Society; Receipt of Petition for Rulemaking

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-23

... that over the next few years, the NRC would be reviewing license applications for new technologies, and... the design of the technology be altered easily to allow for diversion of nuclear material? Could the... of applications. (o) Nuclear Proliferation Assessment. Each applicant for the license of an...

Eight-cm mercury ion thruster system technology

NASA Technical Reports Server (NTRS)

1974-01-01

The technology status of 8 cm diameter electron bombardment ion thrusters is presented. Much of the technology resulting from the 5 cm diameter thruster has been adapted and improved upon to increase the reliability, durability, and efficiency of the 8 cm thruster. Technology discussed includes: dependence of neutralizer tip erosion upon neutralizer flow rate; impregnated and rolled-foil insert cathode performance and life testing; neutralizer position studies; thruster ion beam profile measurements; high voltage pulse ignition; high utilization ion machined accelerator grids; deposition internal and external to the thruster; thruster vectoring systems; thruster cycling life testing and thruster system weights for typical mission applications.

31 CFR 545.526 - Certain importations for diplomatic or official personnel authorized.

Code of Federal Regulations, 2010 CFR

2010-07-01

... TALIBAN (AFGHANISTAN) SANCTIONS REGULATIONS Licenses, Authorizations and Statements of Licensing Policy... ordinarily incident to the importation into the United States of any goods, software, technology or services...

Argonne ARPA-E Battery Research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Amine, Khalil; Sinkula, Michael

Argonne National Laboratory and Envia Systems annouced a licensing agreement for Argonne's patented electrode material technology. Envia plans to commercialize these materials for use in energy storage devices for the next generation of electric, plug-in and hybrid electric vehicles. General Motors Company, LG Chem, BASF and Toda Kyoga have also licensed this suite of Argonne's technologies. For more information visit us at http://www.anl.gov

ecoSPEARS License Signing with Kelvin Manning

NASA Image and Video Library

2017-12-19

NASA Kennedy Space Center's Associate Director Kelvin Manning, center, signs a license agreement with the President and CEO of ecoSPEARS, which allows the company to commercially sell a soil remediation technology developed by a research team at Kennedy. The technology, known as Sorbent Polymer Extraction And Remediation System, is designed to capture and remove polychlorinated biphenyls (PCBs) from contaminated sediments in waterways and wetlands.

Argonne ARPA-E Battery Research

ScienceCinema

Amine, Khalil; Sinkula, Michael

2018-04-16

Argonne National Laboratory and Envia Systems annouced a licensing agreement for Argonne's patented electrode material technology. Envia plans to commercialize these materials for use in energy storage devices for the next generation of electric, plug-in and hybrid electric vehicles. General Motors Company, LG Chem, BASF and Toda Kyoga have also licensed this suite of Argonne's technologies. For more information visit us at http://www.anl.gov

Copyright and Creative Commons License: Can Educators Gain Benefits in the Digital Age?

ERIC Educational Resources Information Center

Lamlert, Wariya

2014-01-01

In this society of digital environment, to keep pace with the technological change that causes the difficulties of information access together with royalty fees remunerated for making use of copyrighted materials, Creative Commons (CC) license is introduced. However, debates on the issues of copyright and CC license have widely arisen. This…

15 CFR 758.1 - The Shipper's Export Declaration (SED) or Automated Export System (AES) record.

Code of Federal Regulations, 2010 CFR

2010-01-01

... that relate to EAR License Exceptions: (1) License Exception Baggage (BAG), as set forth in § 740.14 of.... See 15 CFR 30.53 of the FTSR; (5) License Exception Technology and Software Under Restriction (TSR... entered on the loading document (e.g., Cargo Declaration, manifest, bill of lading, (master) air waybill...

15 CFR 758.1 - The Shipper's Export Declaration (SED) or Automated Export System (AES) record.

Code of Federal Regulations, 2011 CFR

2011-01-01

... that relate to EAR License Exceptions: (1) License Exception Baggage (BAG), as set forth in § 740.14 of.... See 15 CFR 30.53 of the FTSR; (5) License Exception Technology and Software Under Restriction (TSR... entered on the loading document (e.g., Cargo Declaration, manifest, bill of lading, (master) air waybill...

Emerging Issues: Open Educational Resources--How Science Teachers Can Use Open Educational Resources to Revitalize Lessons

ERIC Educational Resources Information Center

Charles, Karen; Rice, Olivia

2012-01-01

The term "open educational resources" (OERs) was first coined by UNESCO in 2005 and refers to "teaching, learning or research materials that are in the public domain or released with an intellectual property license that allows for free use, adaptation, and/or distribution." OERs offer educators what might be termed "value neutral" online…

Climate Neutral Research Campuses | NREL

Science.gov Websites

the background. Set an example for climate neutrality. Use NREL's climate action planning process and more. Climate Action Planning Process Identify the best technology options for a climate action plan . Climate Action Planning Tool Identify the best technology options for a climate action plan. Technology

Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site.

PubMed

Wang, Xiangxi; Zhu, Ling; Dang, Minghao; Hu, Zhongyu; Gao, Qiang; Yuan, Shuai; Sun, Yao; Zhang, Bo; Ren, Jingshan; Kotecha, Abhay; Walter, Thomas S; Wang, Junzhi; Fry, Elizabeth E; Stuart, David I; Rao, Zihe

2017-01-24

Hepatitis A virus (HAV) infects ∼1.4 million people annually and, although there is a vaccine, there are no licensed therapeutic drugs. HAV is unusually stable (making disinfection problematic) and little is known of how it enters cells and releases its RNA. Here we report a potent HAV-specific monoclonal antibody, R10, which neutralizes HAV infection by blocking attachment to the host cell. High-resolution cryo-EM structures of HAV full and empty particles and of the complex of HAV with R10 Fab reveal the atomic details of antibody binding and point to a receptor recognition site at the pentamer interface. These results, together with our observation that the R10 Fab destabilizes the capsid, suggest the use of a receptor mimic mechanism to neutralize virus infection, providing new opportunities for therapeutic intervention.

Neutral and Ion Measurements in the Ionosphere and Thermosphere: Neutral Wind, Ion-drift, Temperatures and Composition

DTIC Science & Technology

2009-09-30

NTR 5025703. HONORS/AWARDS/PRIZES Hollis H. Jones, NASA Goddard AETD Award for Innovative Technology Development, July 2009, Applied Engineering and Technology Directorate, NASA GSFC, Greenbelt, Maryland. 5

How Alzheimer's Changes the Brain

MedlinePlus Videos and Cool Tools

... ideas to treat and prevent the disease. Category Science & Technology License Standard YouTube License Show more Show ... Press Copyright Creators Advertise Developers +YouTube Terms Privacy Policy & Safety Send feedback Test new features Loading... Working... ...

Pediatric Palliative Care: A Personal Story

MedlinePlus

... a pediatric neuroblastoma patient—and her family. The story demonstrates how palliative care can positively influence a patient's and family's experience with illness. Category Science & Technology License Standard YouTube License Show more Show less ...

Experiences with new neutralization technologies for remediation after ISL mining of uranium in Straz Pod Ralskem

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sedlakova, Veronika; Kaspar, Ludvik; Tykal, Tomas

2013-07-01

A big affection of the rock environment and groundwaters occurred during the chemical mining of uranium in the years 1966 to 1996 in the neighbourhood of the town Straz pod Ralskem in the Czech Republic. It is necessary to clean the residual technological solutions (RTS) from the underground. The pH of the solutions in some places is still less than 2 and the concentration of sulphates reaches up to 65 g/l. The remedial activities consist of pumping of the RTS from the ground and reprocessing of the RTS in the surface technologies. The implementation of the new neutralization technologies NDSmore » ML and NDS 10 help us with increasing of the efficiency of the remedial process. The NDS ML technology ('Mother liquor reprocessing station') started its operation in 2009 and it processes the concentrated technological solution from the evaporation station after the alum crystallization (mother liquor) with the concentration of total dissolved solids up to 250 g/l. The principle is the neutralization of the acid solutions with the aid of the lime milk. The suspension is then filtrated in the filter press, the filter cake is deposited in the tailings pond and the filtrate is injected back into the underground rock environment. The NDS 10 technology ('Neutralization and Decontamination Station NDS 10') started its operation in 2012 and it works on the same technological principle as the NDS ML station. The difference is that the NDS 10 station can process higher volume (4.4 m{sup 3}/min) of the RTS with lower concentration of total dissolved solids 20 - 25 g/l. This poster describes the experiences of the state enterprise DIAMO with putting of these two neutralization technologies into operation and with using of the lime milk neutralization in such a large scale. (authors)« less

Development of provisions for oil contaminated soil neutralizing in the conditions of Siberia and the Arctic

NASA Astrophysics Data System (ADS)

Shtripling, L. O.; Kholkin, E. G.

2017-08-01

Siberia and the Arctic zone of the Russian Federation occupy a large area of the country and they differ from other regions in special climatic conditions, in particular, a long period of freezing temperatures and relatively poor infrastructure. The main problem of neutralizing soils contaminated with oil products in conditions of negative ambient temperature is that the contaminated soil is in a frozen state, and it prevents the normal course of neutralization process, so additional energy is required for preparing the soil. There is proposed a technology adapted to the conditions of Siberia and the Arctic for the operational elimination of emergency situations consequences accompanied with oil spills. The technology for neutralizing soils contaminated with petroleum products is based on the encapsulation of a pollutant (reagent capsulation technology) using an alkaline calcium-based reagent. Powdered building quicklime is used as a reagent, and it is a product of roasting carbonate rocks or a mixture of this product with mineral additives (calcium oxide). The encapsulated material obtained as a result of neutralizing soils contaminated with petroleum products is resistant to natural and man-made factors such as moisture, temperature fluctuations, acid rain and high pressure. Energy use from the chemical detoxification exothermic process of soils contaminated with petroleum products in combination with the forced supply of carbon dioxide to the neutralization zone during the formation of a shell from calcium carbonate on the surface of the pollutant makes it possible to neutralize soils contaminated with oil products in the extreme climatic conditions of the Arctic using reagent Encapsulation. The principle of equipment operation that allows neutralizing soils contaminated with petroleum products in the natural and climatic conditions of the Arctic using reagent capsulation technology has been described. The results of experimental studies have been presented that allow to determine the optimum quantity of the reagent necessary for effective neutralization completion of snow contaminated with engine oil and soils contaminated with petroleum products depending on the degree of pollution and the type of pollutant. The conducted studies confirm that the technology of reagent capsulation is suitable for neutralizing soils and snow contaminated with gasoline, diesel fuel and engine oil.

78 FR 3440 - Government-Owned Inventions; Availability for Licensing

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-16

... is housed within Ty21a, an attenuated typhoid fever strain that is licensed for human use as a [email protected] . Typhoid-Plague Bivalent Vaccine Description of Technology: Yersinia pestis (Y. pestis...

Implementation Plan for Qualification of Sodium-Cooled Fast Reactor Technology Information

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moe, Wayne; Honma, George

This document identifies and discusses implementation elements that can be used to facilitate consistent and systematic evaluation processes relating to quality attributes of technical information (with focus on SFR technology) that will be used to support licensing of advanced reactor designs. Information may include, but is not limited to, design documents for SFRs, research-and-development (R&D) data and associated documents, test plans and associated protocols, operations and test data, international research data, technical reports, and information associated with past U.S. Nuclear Regulatory Commission (NRC) reviews of SFR designs. The approach for determining acceptability of test data, analysis, and/or other technical informationmore » is based on guidance provided in INL/EXT-15-35805, “Guidance on Evaluating Historic Technology Information for Use in Advanced Reactor Licensing.” The implementation plan can be adopted into a working procedure at each of the national laboratories performing data qualification, or by applicants seeking future license application for advanced reactor technology.« less

Special Report on "Allegations of Conflict of Interest Regarding Licensing of PROTECT by Argonne National Laboratory"

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2009-08-01

In February 2009, the Office of Inspector General received a letter from Congressman Mark Steven Kirk of Illinois, which included constituent allegations that an exclusive technology licensing agreement by Argonne National Laboratory was tainted by inadequate competition, conflicts of interest, and other improprieties. The technology in question was for the Program for Response Options and Technology Enhancements for Chemical/Biological Terrorism, commonly referred to as PROTECT. Because of the importance of the Department of Energy's technology transfer program, especially as implementation of the American Recovery and Reinvestment Act matures, we reviewed selected aspects of the licensing process for PROTECT to determinemore » whether the allegations had merit. In summary, under the facts developed during our review, it was understandable that interested parties concluded that there was a conflict of interest in this matter and that Argonne may have provided the successful licensee with an unfair advantage. In part, this was consistent with aspects of the complaint from Congressman Kirk's constituent.« less

Not "Just a Tool': A Triadic Model of Technological Non-Neutrality

ERIC Educational Resources Information Center

Rose, Ellen

2012-01-01

The author describes the three bases upon which she rejects the assumption that a technology and its use are neutral: every technology predisposes a certain use; shapes habits of mind and social organizations; and is the outcome of deliberate choices made by individuals and societies. She then proposes a "triadic model" of technological…

The Optimal Licensing Contract in a Differentiated Stackelberg Model

PubMed Central

Hong, Xianpei; Yang, Lijun; Zhang, Huaige; Zhao, Dan

2014-01-01

This paper extends the work of Wang (2002) by considering a differentiated Stackelberg model, when the leader firm is an inside innovator and licenses its new technology by three options, that is, fixed-fee licensing, royalty licensing, and two-part tariff licensing. The main contributions and conclusions of this paper are threefold. First of all, this paper derives a very different result from Wang (2002). We show that, with a nondrastic innovation, royalty licensing is always better than fixed-fee licensing for the innovator; with a drastic innovation, royalty licensing is superior to fixed-fee licensing for small values of substitution coefficient d; however when d becomes closer to 1, neither fee nor royalty licensing will occur. Secondly, this paper shows that the innovator is always better off in case of two-part tariff licensing than fixed-fee licensing no matter what the innovation size is. Thirdly, the innovator always prefers to license its nondrastic innovation by means of a two-part tariff instead of licensing by means of a royalty; however, with a drastic innovation, the optimal licensing strategy can be either a two-part tariff or a royalty, depending upon the differentiation of the goods. PMID:24683342

The optimal licensing contract in a differentiated Stackelberg model.

PubMed

Hong, Xianpei; Yang, Lijun; Zhang, Huaige; Zhao, Dan

2014-01-01

This paper extends the work of Wang (2002) by considering a differentiated Stackelberg model, when the leader firm is an inside innovator and licenses its new technology by three options, that is, fixed-fee licensing, royalty licensing, and two-part tariff licensing. The main contributions and conclusions of this paper are threefold. First of all, this paper derives a very different result from Wang (2002). We show that, with a nondrastic innovation, royalty licensing is always better than fixed-fee licensing for the innovator; with a drastic innovation, royalty licensing is superior to fixed-fee licensing for small values of substitution coefficient d; however when d becomes closer to 1, neither fee nor royalty licensing will occur. Secondly, this paper shows that the innovator is always better off in case of two-part tariff licensing than fixed-fee licensing no matter what the innovation size is. Thirdly, the innovator always prefers to license its nondrastic innovation by means of a two-part tariff instead of licensing by means of a royalty; however, with a drastic innovation, the optimal licensing strategy can be either a two-part tariff or a royalty, depending upon the differentiation of the goods.

New Health Technologies: A UK Perspective Comment on "Providing Value to New Health Technology: The Early Contribution of Entrepreneurs, Investors, and Regulatory Agencies".

PubMed

Parvizi, Nassim; Parvizi, Sahar

2017-05-09

New health technologies require development and evaluation ahead of being incorporated into the patient care pathway. In light of the recent publication by Lehoux et al who discuss the role of entrepreneurs, investors and regulators in providing value to new health technologies, we summarise the processes involved in making new health technologies available for use in the United Kingdom. © 2017 The Author(s); Published by Kerman University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Lethal factor antibodies contribute to lethal toxin neutralization in recipients of anthrax vaccine precipitated.

PubMed

Dumas, Eric K; Garman, Lori; Cuthbertson, Hannah; Charlton, Sue; Hallis, Bassam; Engler, Renata J M; Choudhari, Shyamal; Picking, William D; James, Judith A; Farris, A Darise

2017-06-08

A major difference between two currently licensed anthrax vaccines is presence (United Kingdom Anthrax Vaccine Precipitated, AVP) or absence (United States Anthrax Vaccine Adsorbed, AVA) of quantifiable amounts of the Lethal Toxin (LT) component Lethal Factor (LF). The primary immunogen in both vaccine formulations is Protective Antigen (PA), and LT-neutralizing antibodies directed to PA are an accepted correlate of vaccine efficacy; however, vaccination studies in animal models have demonstrated that LF antibodies can be protective. In this report we compared humoral immune responses in cohorts of AVP (n=39) and AVA recipients (n=78) matched 1:2 for number of vaccinations and time post-vaccination, and evaluated whether the LF response contributes to LT neutralization in human recipients of AVP. PA response rates (≥95%) and PA IgG concentrations were similar in both groups; however, AVP recipients exhibited higher LT neutralization ED 50 values (AVP: 1464.0±214.7, AVA: 544.9±83.2, p<0.0001) and had higher rates of LF IgG positivity (95%) compared to matched AVA vaccinees (1%). Multiple regression analysis revealed that LF IgG makes an independent and additive contribution to the LT neutralization response in the AVP group. Affinity purified LF antibodies from two independent AVP recipients neutralized LT and bound to LF Domain 1, confirming contribution of LF antibodies to LT neutralization. This study documents the benefit of including an LF component to PA-based anthrax vaccines. Copyright © 2017 Elsevier Ltd. All rights reserved.

Sandia National Laboratories: National Security Missions: International

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Sandia National Laboratories: Microsystems Science & Technology Center

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Sandia National Laboratories: Sandia Enabled Communications and

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Useful new technology

NASA Technical Reports Server (NTRS)

1971-01-01

An information booklet on the Technology Utilization program is presented. Industrial benefits, how to obtain technological data, special publications, Regional Dissemination Centers, multidisciplinary application teams, interagency activities, and patents and licenses are described briefly.

Sandia National Laboratories: News

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Sandia National Laboratories: Careers

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Sandia National Laboratories: Mission

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Sandia National Laboratories: Research

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Sandia National Laboratories:

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Sandia National Laboratories: Feedback

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Mission & Role | NCI Technology Transfer Center | TTC

Cancer.gov

The NCI TTC serves as the focal point for implementing the Federal Technology Transfer Act to utilize patents as incentive for commercial development of technologies and to establish research collaborations and licensing among academia, federal laboratories, non-profit organizations, and industry. The TTC supports technology development activities for the National Cancer Institute and nine other NIH Institutes and Centers. TTC staff negotiate co-development agreements and licenses with universities, non-profit organizations, and pharmaceutical and biotechnology companies to ensure compliance with Federal statutes, regulations and the policies of the National Institutes of Health. TTC also reviews employee invention reports and makes recommendations concerning filing of domestic and foreign patent applications. | [google6f4cd5334ac394ab.html

76 FR 40383 - National Institutes of Health

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-08

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Government-Owned Inventions; Availability for Licensing AGENCY: Public Health Service, National Institutes of Health, HHS. ACTION: Notice... the indicated licensing contact at the Office of Technology Transfer, National Institutes of Health...

ADVANCED SEISMIC BASE ISOLATION METHODS FOR MODULAR REACTORS

DOE Office of Scientific and Technical Information (OSTI.GOV)

E. Blanford; E. Keldrauk; M. Laufer

2010-09-20

Advanced technologies for structural design and construction have the potential for major impact not only on nuclear power plant construction time and cost, but also on the design process and on the safety, security and reliability of next generation of nuclear power plants. In future Generation IV (Gen IV) reactors, structural and seismic design should be much more closely integrated with the design of nuclear and industrial safety systems, physical security systems, and international safeguards systems. Overall reliability will be increased, through the use of replaceable and modular equipment, and through design to facilitate on-line monitoring, in-service inspection, maintenance, replacement,more » and decommissioning. Economics will also receive high design priority, through integrated engineering efforts to optimize building arrangements to minimize building heights and footprints. Finally, the licensing approach will be transformed by becoming increasingly performance based and technology neutral, using best-estimate simulation methods with uncertainty and margin quantification. In this context, two structural engineering technologies, seismic base isolation and modular steel-plate/concrete composite structural walls, are investigated. These technologies have major potential to (1) enable standardized reactor designs to be deployed across a wider range of sites, (2) reduce the impact of uncertainties related to site-specific seismic conditions, and (3) alleviate reactor equipment qualification requirements. For Gen IV reactors the potential for deliberate crashes of large aircraft must also be considered in design. This report concludes that base-isolated structures should be decoupled from the reactor external event exclusion system. As an example, a scoping analysis is performed for a rectangular, decoupled external event shell designed as a grillage. This report also reviews modular construction technology, particularly steel-plate/concrete construction using factory prefabricated structural modules, for application to external event shell and base isolated structures.« less

Sandia National Laboratories: Employee & Retiree Resources: Emergency

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Sandia National Laboratories: Sandia National Laboratories: Missions:

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Sandia National Laboratories: Visiting Research Scholars

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Sandia National Laboratories: Research: Biodefense

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Sandia National Laboratories: Cooperative Monitoring Center

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Sandia National Laboratories: Research: Bioscience

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Sandia National Laboratories: Integrated Military Systems

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Spontaneous and electric field-controlled front-rear polarization of human keratinocytes.

PubMed

Saltukoglu, Deniz; Grünewald, Julian; Strohmeyer, Nico; Bensch, Robert; Ulbrich, Maximilian H; Ronneberger, Olaf; Simons, Matias

2015-12-01

It has long been known that electrical fields (EFs) are able to influence the direction of migrating cells, a process commonly referred to as electrotaxis or galvanotaxis. Most studies have focused on migrating cells equipped with an existing polarity before EF application, making it difficult to delineate EF-specific pathways. Here we study the initial events in front-rear organization of spreading keratinocytes to dissect the molecular requirements for random and EF-controlled polarization. We find that Arp2/3-dependent protrusive forces and Rac1/Cdc42 activity were generally required for both forms of polarization but were dispensable for controlling the direction of EF-controlled polarization. By contrast, we found a crucial role for extracellular pH as well as G protein coupled-receptor (GPCR) or purinergic signaling in the control of directionality. The normal direction of polarization toward the cathode was reverted by lowering extracellular pH. Polarization toward the anode was also seen at neutral pH when GPCR or purinergic signaling was inhibited. However, the stepwise increase of extracellular pH in this scenario led to restoration of cathodal polarization. Overall our work puts forward a model in which the EF uses distinct polarization pathways. The cathodal pathway involves GPCR/purinergic signaling and is dominant over the anodal pathway at neutral pH. © 2015 Saltukoglu et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Federal Technology Transfer Act (FTTA)

EPA Pesticide Factsheets

EPA's Federal Technology Transfer Act (FTTA) is a mechanism with which EPA can patent its inventions and license them to companies, through which innovative technologies can enter the marketplace to improve the environment and human health.

78 FR 3906 - Prospective Grant of a Co-Exclusive License: Adenovirus-Based Controls and Calibrators for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-17

... contemplated license should be directed to: Uri Reichman, Ph.D., M.B.A, Office of Technology Transfer, National... calibrators and controls for molecular diagnostics (e.g. real time PCR tests). The prospective co-exclusive...

Copyright, Licensing Agreements and Gateways.

ERIC Educational Resources Information Center

Elias, Arthur W.

1990-01-01

Discusses technological developments in information distribution and management in relation to concepts of ownership. A historical overview of the concept of copyright is presented; licensing elements for databases are examined; and implications for gateway systems are explored, including ownership, identification of users, and allowable uses of…

78 FR 64497 - Information Collection Being Reviewed by the Federal Communications Commission

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-29

... information technology; and ways to further reduce the information collection burden on small business....: 3060-0865. Title: Wireless Telecommunications Bureau Universal Licensing System Recordkeeping and Third...-1, ``Wireless Services Licensing Records,'' to cover the collection, maintenance, use(s), and...

47 CFR 5.54 - Types of authorizations available.

Code of Federal Regulations, 2013 CFR

2013-10-01

... experimentation for the development and advancement of new broadcast technology, equipment, systems or services... testing experimental radio license. This type of license is issued to hospitals and health care institutions that demonstrate expertise in testing and operation of experimental medical devices that use...

47 CFR 5.54 - Types of authorizations available.

Code of Federal Regulations, 2014 CFR

2014-10-01

... experimentation for the development and advancement of new broadcast technology, equipment, systems or services... testing experimental radio license. This type of license is issued to hospitals and health care institutions that demonstrate expertise in testing and operation of experimental medical devices that use...

10 CFR 72.212 - Conditions of general license issued under § 72.210.

Code of Federal Regulations, 2012 CFR

2012-01-01

... guard or watchman on patrol in lieu of video surveillance technology; (v) For the purpose of this... storage under this general license are those shown in § 170.31 of this chapter. [55 FR 29191, July 18...

Autonomous mine detection system (AMDS) neutralization payload module

NASA Astrophysics Data System (ADS)

Majerus, M.; Vanaman, R.; Wright, N.

2010-04-01

The Autonomous Mine Detection System (AMDS) program is developing a landmine and explosive hazards standoff detection, marking, and neutralization system for dismounted soldiers. The AMDS Capabilities Development Document (CDD) has identified the requirement to deploy three payload modules for small robotic platforms: mine detection and marking, explosives detection and marking, and neutralization. This paper addresses the neutralization payload module. There are a number of challenges that must be overcome for the neutralization payload module to be successfully integrated into AMDS. The neutralizer must meet stringent size, weight, and power (SWaP) requirements to be compatible with a small robot. The neutralizer must be effective against a broad threat, to include metal and plastic-cased Anti-Personnel (AP) and Anti-Tank (AT) landmines, explosive devices, and Unexploded Explosive Ordnance (UXO.) It must adapt to a variety of threat concealments, overburdens, and emplacement methods, to include soil, gravel, asphalt, and concrete. A unique neutralization technology is being investigated for adaptation to the AMDS Neutralization Module. This paper will describe review this technology and how the other two payload modules influence its design for minimizing SWaP. Recent modeling and experimental efforts will be included.

SITE TECHNOLOGY CAPSULE; MULTI-VENDOR BIOREMEDIATION DEMONSTRATION PROJECT: ENVIRONMENTAL LABORATORIES/SBP TECHNOLOGIES' UVB VACUUM VAPORIZATION WELL PROCESS

EPA Science Inventory

This technology capsule summarizes the findings of an evaluation of the Unterdruck-Verdampfer-Brunnen (UVB) technology developed by IEG Technologies (IEG) and licensed in the eastern United States by Environmental Laboratories, Inc. (ELI) and SBP Technologies, Inc. (SBP). This e...

Potential strategies for the eradication of multidrug-resistant Gram-negative bacterial infections.

PubMed

Huwaitat, Rawan; McCloskey, Alice P; Gilmore, Brendan F; Laverty, Garry

2016-07-01

Antimicrobial resistance is one of the leading threats to society. The increasing burden of multidrug-resistant Gram-negative infection is particularly concerning as such bacteria are demonstrating resistance to nearly all currently licensed therapies. Various strategies have been hypothesized to treat multidrug-resistant Gram-negative infections including: targeting the Gram-negative outer membrane; neutralization of lipopolysaccharide; inhibition of bacterial efflux pumps and prevention of protein folding. Silver and silver nanoparticles, fusogenic liposomes and nanotubes are potential strategies for extending the activity of licensed, Gram-positive selective, antibiotics to Gram-negatives. This may serve as a strategy to fill the current void in pharmaceutical development in the short term. This review outlines the most promising strategies that could be implemented to solve the threat of multidrug-resistant Gram-negative infections.

The Collision of Plausibility with Reality: Lifting the Veil of the Ethical Neutrality of Technology

ERIC Educational Resources Information Center

Borgmann, Albert

2012-01-01

Technology, thought of as the ensemble of utilities and devices and of their impact on our lives, proceeds in steps, each of which seems plausible. This kind of development also encourages the view that technology is value-neutral. It always can be used both for good and ill, and we decide how to use it. The production of food and the development…

Sandia National Laboratories: Working with Sandia

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Sandia National Laboratories: News: Economic Impact

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Sandia National Laboratories: News: Publications: Environmental Reports

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Sandia National Laboratories: Sandia National Laboratories: News: Events

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Sandia National Laboratories: About Sandia: Environmental Responsibility

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Sandia National Laboratories: About Sandia: Community Involvement

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Sandia National Laboratories: News: Publications: HPC Reports

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Sandia National Laboratories: Community Involvement: Volunteer Programs

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Sandia National Laboratories: News: Search Sandia Publications

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Sandia National Laboratories: Working with Sandia: Small Business

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Sandia National Laboratories: News: Publications: Strategic Plan

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Sandia National Laboratories: News: Media Resources: Media Contacts

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Sandia National Laboratories: Employee & Retiree Resources: Technical

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Sandia National Laboratories: Z Pulsed Power Facility

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Sandia National Laboratories: National Security Missions: Defense Systems

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Sandia National Laboratories: Advanced Simulation and Computing

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Sandia National Laboratories: News: Publications: Annual Report

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Sandia National Laboratories: Employee & Retiree Resources: Remote Access

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Inspection report: the Department of Energy's export licensing process for dual-use and munitions commodities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Friedman, Gregory H.

1999-05-01

Export of commodities, encouraged by both the private sector and the Federal Government, helps to improve our position in the global economy and is in the national interest of the US. However, exports of commodities or technologies, without regard to whether they may significantly contribute to the military potential of individual countries or combination of countries or enhance the proliferation of weapons of mass destruction, may adversely affect the national security of the US. The Federal Government, therefore, implements several laws, Executive Orders, and regulations to control the export of certain commodities and technologies. These commodities and technologies require amore » license for export. Some of the controlled items are designated as ''dual-use,'' that is, commodities and technologies that have both civilian and military application. Some dual-use commodities are designated as ''nuclear dual-use''--items controlled for nuclear nonproliferation purposes. Another group of controlled commodities is designated as munitions, which are goods and technologies that have solely military uses. The Department of Energy (Energy) conducts reviews of export license applications for nuclear dual-use items and certain munitions. On August 26, 1998, the Chairman of the Senate Committee on Governmental Affairs requested that the Inspectors General from the Departments of Commerce, Defense, Energy, State, and Treasury, and the Central Intelligence Agency (CIA), update and expand on a 1993 interagency review conducted by the Inspectors General of the Departments of Commerce, Defense, Energy, and State of the export licensing processes for dual-use and munitions commodities.« less

Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein.

PubMed

Tian, Daiyin; Battles, Michael B; Moin, Syed M; Chen, Man; Modjarrad, Kayvon; Kumar, Azad; Kanekiyo, Masaru; Graepel, Kevin W; Taher, Noor M; Hotard, Anne L; Moore, Martin L; Zhao, Min; Zheng, Zi-Zheng; Xia, Ning-Shao; McLellan, Jason S; Graham, Barney S

2017-11-30

A licensed vaccine for respiratory syncytial virus (RSV) is unavailable, and passive prophylaxis with the antibody palivizumab is restricted to high-risk infants. Recently isolated antibodies 5C4 and D25 are substantially more potent than palivizumab, and a derivative of D25 is in clinical trials. Here we show that unlike D25, 5C4 preferentially neutralizes subtype A viruses. The crystal structure of 5C4 bound to the RSV fusion (F) protein reveals that the overall binding mode of 5C4 is similar to that of D25, but their angles of approach are substantially different. Mutagenesis and virological studies demonstrate that RSV F residue 201 is largely responsible for the subtype specificity of 5C4. These results improve our understanding of subtype-specific immunity and the neutralization breadth requirements of next-generation antibodies, and thereby contribute to the design of broadly protective RSV vaccines.

The Enhanced Driver’s License: Collateral Gains or Collateral Damage?

DTIC Science & Technology

2012-12-01

fact, are only detectible under a high- powered electron microscope. The indication, thus, is that the improvements made to the driver’s license...security environment, say airport security, there is no time to analyze driver’s licenses under a high- powered electron microscope to ensure they are...95 Advancements in recent decades have reduced the size and cost of RFID technology and as such, have increased the number of purposes ( supply

77 FR 75635 - Agency Information Collection Activities; Proposed Collection; Comment Request; Medicated Feed...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-21

...] Agency Information Collection Activities; Proposed Collection; Comment Request; Medicated Feed Mill... notice. This notice solicits comments on the medicated feed mill licensing system. DATES: Submit written... techniques, when appropriate, and other forms of information technology. Medicated Feed Mill Licensing...

75 FR 21634 - Government-Owned Inventions; Availability for Licensing

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-26

... such as cutaneous T-cell lymphoma (CTCL) and skin disorders such as lupus, contact dermatitis, and drug... result in contact dermatitis, exanthematous reactions, and photoallergic reactions. A topical formulation... the indicated licensing contact at the Office of Technology Transfer, National Institutes of Health...

77 FR 36282 - Government-Owned Inventions; Availability for Licensing

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-18

... of federally-funded research and development. Foreign patent applications are filed on selected...-2012/0--Research Tool. Patent protection is not being pursued for this technology. Licensing Contact: Fatima Sayyid, M.H.P.M.; 301-435-4521; [email protected] . Collaborative Research Opportunity...

78 FR 70072 - Notice of Intent To Grant Exclusive License

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-22

... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice 13-132] Notice of Intent To Grant Exclusive License AGENCY: National Aeronautics and Space Administration. ACTION: Notice of intent to grant exclusive... Volatiles From Soil Using Microwave Processes, to Space Resources Extraction Technology, Inc., having its...

76 FR 17841 - Notice of Intent To License Government-Owned Inventions; Intent To License Exclusively

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-31

... , U.S. Army Edgewood Chemical Biological Center (ECBC), AMSRD-ECB-PI-BP-TT, Bldg E3330/Rm 241 5183... Technology Applications, U.S. Army Edgewood Chemical Biological Center, AMSRD-ECB-PI-BP-TT, Bldg E3330/Rm 241...

78 FR 25137 - Radio Experimentation and Market Trials-Streamlining Rules

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-29

...This document revises and streamlines the Commission rules to modernize the Experimental Radio Service (ERS). The rules adopted in the Report and Order updates the ERS to a more flexible framework to keep pace with the speed of modern technological change while continuing to provide an environment where creativity can thrive. To accomplish this transition, the Commission created three new types of ERS licenses--the program license, the medical testing license, and the compliance testing license--to benefit the development of new technologies, expedite their introduction to the marketplace, and unleash the full power of innovators to keep the United States at the forefront of the communications industry. The Commission's actions also modify the market trial rules to eliminate confusion and more clearly articulate its policies with respect to marketing products prior to equipment certification. The Commission believes that these actions will remove regulatory barriers to experimentation, thereby permitting institutions to move from concept to experimentation to finished product more rapidly and to more quickly implement creative problem- solving methodologies.

Sandia National Laboratories: Working with Sandia: Current Suppliers

Science.gov Websites

Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios Report Economic Impact Environmental Reports Fact Sheets Search Sandia Publications Labs Accomplishments /Technology Transfer Technology Partnerships Economic Impact Facebook Twitter YouTube Flickr RSS Top Current

Sandia National Laboratories: Working with Sandia: Prospective Suppliers

Science.gov Websites

Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios Report Economic Impact Environmental Reports Fact Sheets Search Sandia Publications Labs Accomplishments /Technology Transfer Technology Partnerships Economic Impact Facebook Twitter YouTube Flickr RSS Working with

Sandia National Laboratories: What Sandia Looks For In Our Suppliers

Science.gov Websites

Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

Sandia National Laboratories: Working with Sandia: What Does Sandia Buy?

Science.gov Websites

Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

Sandia National Laboratories: Sandia inks pact with Fire and Rescue

Science.gov Websites

; Technology Defense Systems & Assessments About Defense Systems & Assessments Program Areas Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios

Nasal Immunization Confers High Avidity Neutralizing Antibody Response and Immunity to Primary and Recurrent Genital Herpes in Guinea Pigs

PubMed Central

Persson, Josefine; Zhang, Yuan; Olafsdottir, Thorunn A.; Thörn, Karolina; Cairns, Tina M.; Wegmann, Frank; Sattentau, Quentin J.; Eisenberg, Roselyn J.; Cohen, Gary H.; Harandi, Ali M.

2016-01-01

Genital herpes is one of the most prevalent sexually transmitted infections in both the developing and developed world. Following infection, individuals experience life-long latency associated with sporadic ulcerative outbreaks. Despite many efforts, no vaccine has yet been licensed for human use. Herein, we demonstrated that nasal immunization with an adjuvanted HSV-2 gD envelope protein mounts significant protection to primary infection as well as the establishment of latency and recurrent genital herpes in guinea pigs. Nasal immunization was shown to elicit specific T cell proliferative and IFN-γ responses as well as systemic and vaginal gD-specific IgG antibody (Ab) responses. Furthermore, systemic IgG Abs displayed potent HSV-2 neutralizing properties and high avidity. By employing a competitive surface plasmon resonance (SPR) analysis combined with a battery of known gD-specific neutralizing monoclonal Abs (MAbs), we showed that nasal immunization generated IgG Abs directed to two major discontinuous neutralizing epitopes of gD. These results highlight the potential of nasal immunization with an adjuvanted HSV-2 envelope protein for induction of protective immunity to primary and recurrent genital herpes. PMID:28082979

Nasal Immunization Confers High Avidity Neutralizing Antibody Response and Immunity to Primary and Recurrent Genital Herpes in Guinea Pigs.

PubMed

Persson, Josefine; Zhang, Yuan; Olafsdottir, Thorunn A; Thörn, Karolina; Cairns, Tina M; Wegmann, Frank; Sattentau, Quentin J; Eisenberg, Roselyn J; Cohen, Gary H; Harandi, Ali M

2016-01-01

Genital herpes is one of the most prevalent sexually transmitted infections in both the developing and developed world. Following infection, individuals experience life-long latency associated with sporadic ulcerative outbreaks. Despite many efforts, no vaccine has yet been licensed for human use. Herein, we demonstrated that nasal immunization with an adjuvanted HSV-2 gD envelope protein mounts significant protection to primary infection as well as the establishment of latency and recurrent genital herpes in guinea pigs. Nasal immunization was shown to elicit specific T cell proliferative and IFN-γ responses as well as systemic and vaginal gD-specific IgG antibody (Ab) responses. Furthermore, systemic IgG Abs displayed potent HSV-2 neutralizing properties and high avidity. By employing a competitive surface plasmon resonance (SPR) analysis combined with a battery of known gD-specific neutralizing monoclonal Abs (MAbs), we showed that nasal immunization generated IgG Abs directed to two major discontinuous neutralizing epitopes of gD. These results highlight the potential of nasal immunization with an adjuvanted HSV-2 envelope protein for induction of protective immunity to primary and recurrent genital herpes.

Vaccination of rhesus macaques with the anthrax vaccine adsorbed vaccine produces a serum antibody response that effectively neutralizes receptor-bound protective antigen in vitro.

PubMed

Clement, Kristin H; Rudge, Thomas L; Mayfield, Heather J; Carlton, Lena A; Hester, Arelis; Niemuth, Nancy A; Sabourin, Carol L; Brys, April M; Quinn, Conrad P

2010-11-01

Anthrax toxin (ATx) is composed of the binary exotoxins lethal toxin (LTx) and edema toxin (ETx). They have separate effector proteins (edema factor and lethal factor) but have the same binding protein, protective antigen (PA). PA is the primary immunogen in the current licensed vaccine anthrax vaccine adsorbed (AVA [BioThrax]). AVA confers protective immunity by stimulating production of ATx-neutralizing antibodies, which could block the intoxication process at several steps (binding of PA to the target cell surface, furin cleavage, toxin complex formation, and binding/translocation of ATx into the cell). To evaluate ATx neutralization by anti-AVA antibodies, we developed two low-temperature LTx neutralization activity (TNA) assays that distinguish antibody blocking before and after binding of PA to target cells (noncomplexed [NC] and receptor-bound [RB] TNA assays). These assays were used to investigate anti-PA antibody responses in AVA-vaccinated rhesus macaques (Macaca mulatta) that survived an aerosol challenge with Bacillus anthracis Ames spores. Results showed that macaque anti-AVA sera neutralized LTx in vitro, even when PA was prebound to cells. Neutralization titers in surviving versus nonsurviving animals and between prechallenge and postchallenge activities were highly correlated. These data demonstrate that AVA stimulates a myriad of antibodies that recognize multiple neutralizing epitopes and confirm that change, loss, or occlusion of epitopes after PA is processed from PA83 to PA63 at the cell surface does not significantly affect in vitro neutralizing efficacy. Furthermore, these data support the idea that the full-length PA83 monomer is an appropriate immunogen for inclusion in next-generation anthrax vaccines.

15 CFR 742.5 - Missile technology.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Missile technology. 742.5 Section 742... BASED CONTROLS § 742.5 Missile technology. (a) License requirements. (1) In support of U.S. foreign... establish the existence of a contract. (d) Missile Technology Control Regime. Missile Technology Control...

76 FR 76741 - Government-Owned Inventions; Availability for Licensing

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-08

... of federally-funded research and development. Foreign patent applications are filed on selected...: Licensing information and copies of the U.S. patent applications listed below may be obtained by writing to... patent applications. Novel NSAIDs for the Treatment of Human Diseases Description of Technology: The...

Sandia National Laboratories: News: Publications

Science.gov Websites

Audit Sandia's Economic Impact Licensing & Technology Transfer Browse Technology Portfolios Report Economic Impact Environmental Reports Fact Sheets Search Sandia Publications Labs Accomplishments of the Labs, highlighting new programs, technologies, and community activities. Economic Impact

What Is Technology Transfer? | Poster

Cancer.gov

The NCI Technology Transfer Center (TTC) facilitates partnerships between NIH research laboratories and external partners. With a team of technology transfer specialists, NCI TTC guides interactions from discovery to patenting, as well as from collaboration and invention development to licensing.

Patents and innovation in cancer therapeutics: lessons from CellPro.

PubMed

Bar-Shalom, Avital; Cook-Deegan, Robert

2002-01-01

This article discusses the interaction between intellectual property and cancer treatment. CellPro developed a stem cell separation technology based on research at the Fred Hutchinson Cancer Center. A patent with broad claims to bone marrow stem cell antibodies had been awarded to Johns Hopkins University and licensed to Baxter Healthcare under the 1980 Bayh-Dole Act to promote commercial use of inventions from federally funded research. CellPro got FDA approval more than two years before Baxter but lost patent infringement litigation. NIH elected not to compel Hopkins to license its patents to CellPro. CellPro went out of business, selling its technology to its competitor. Decisions at both firms and university licensing offices, and policies at the Patent and Trademark Office, NIH, and the courts influenced the outcome.

Flavivirus-induced antibody cross-reactivity

PubMed Central

Mansfield, Karen L.; Horton, Daniel L.; Johnson, Nicholas; Li, Li; Barrett, Alan D. T.; Smith, Derek J.; Galbraith, Sareen E.; Solomon, Tom

2011-01-01

Dengue viruses (DENV) cause countless human deaths each year, whilst West Nile virus (WNV) has re-emerged as an important human pathogen. There are currently no WNV or DENV vaccines licensed for human use, yet vaccines exist against other flaviviruses. To investigate flavivirus cross-reactivity, sera from a human cohort with a history of vaccination against tick-borne encephalitis virus (TBEV), Japanese encephalitis virus (JEV) and yellow fever virus (YFV) were tested for antibodies by plaque reduction neutralization test. Neutralization of louping ill virus (LIV) occurred, but no significant neutralization of Murray Valley encephalitis virus was observed. Sera from some individuals vaccinated against TBEV and JEV neutralized WNV, which was enhanced by YFV vaccination in some recipients. Similarly, some individuals neutralized DENV-2, but this was not significantly influenced by YFV vaccination. Antigenic cartography techniques were used to generate a geometric illustration of the neutralization titres of selected sera against WNV, TBEV, JEV, LIV, YFV and DENV-2. This demonstrated the individual variation in antibody responses. Most sera had detectable titres against LIV and some had titres against WNV and DENV-2. Generally, LIV titres were similar to titres against TBEV, confirming the close antigenic relationship between TBEV and LIV. JEV was also antigenically closer to TBEV than WNV, using these sera. The use of sera from individuals vaccinated against multiple pathogens is unique relative to previous applications of antigenic cartography techniques. It is evident from these data that notable differences exist between amino acid sequence identity and mapped antigenic relationships within the family Flaviviridae. PMID:21900425

Flavivirus-induced antibody cross-reactivity.

PubMed

Mansfield, Karen L; Horton, Daniel L; Johnson, Nicholas; Li, Li; Barrett, Alan D T; Smith, Derek J; Galbraith, Sareen E; Solomon, Tom; Fooks, Anthony R

2011-12-01

Dengue viruses (DENV) cause countless human deaths each year, whilst West Nile virus (WNV) has re-emerged as an important human pathogen. There are currently no WNV or DENV vaccines licensed for human use, yet vaccines exist against other flaviviruses. To investigate flavivirus cross-reactivity, sera from a human cohort with a history of vaccination against tick-borne encephalitis virus (TBEV), Japanese encephalitis virus (JEV) and yellow fever virus (YFV) were tested for antibodies by plaque reduction neutralization test. Neutralization of louping ill virus (LIV) occurred, but no significant neutralization of Murray Valley encephalitis virus was observed. Sera from some individuals vaccinated against TBEV and JEV neutralized WNV, which was enhanced by YFV vaccination in some recipients. Similarly, some individuals neutralized DENV-2, but this was not significantly influenced by YFV vaccination. Antigenic cartography techniques were used to generate a geometric illustration of the neutralization titres of selected sera against WNV, TBEV, JEV, LIV, YFV and DENV-2. This demonstrated the individual variation in antibody responses. Most sera had detectable titres against LIV and some had titres against WNV and DENV-2. Generally, LIV titres were similar to titres against TBEV, confirming the close antigenic relationship between TBEV and LIV. JEV was also antigenically closer to TBEV than WNV, using these sera. The use of sera from individuals vaccinated against multiple pathogens is unique relative to previous applications of antigenic cartography techniques. It is evident from these data that notable differences exist between amino acid sequence identity and mapped antigenic relationships within the family Flaviviridae.

Neutralization of Yersinia pestis-mediated macrophage cytotoxicity by anti-LcrV antibodies and its correlation with protective immunity in a mouse model of bubonic plague.

PubMed

Zauberman, Ayelet; Cohen, Sara; Levy, Yinon; Halperin, Gideon; Lazar, Shirley; Velan, Baruch; Shafferman, Avigdor; Flashner, Yehuda; Mamroud, Emanuelle

2008-03-20

Plague is a life-threatening disease caused by Yersinia pestis, for which effective-licensed vaccines and reliable predictors of in vivo immunity are lacking. V antigen (LcrV) is a major Y. pestis virulence factor that mediates translocation of the cytotoxic Yersinia protein effectors (Yops). It is a well-established protective antigen and a part of currently tested plague subunit vaccines. We have developed a highly sensitive in vitro macrophage cytotoxicity neutralization assay which is mediated by anti-LcrV antibodies; and studied the potential use of these neutralizing antibodies as an in vitro correlate of plague immunity in mice. The assay is based on a Y. pestis strain with enhanced cytotoxicity to macrophages in which endogenous yopJ was replaced by the more effectively translocated yopP of Y. enterocolitica O:8. Mice passively immunized with rabbit anti-LcrV IgG or actively immunized with recombinant LcrV were protected against lethal doses of a virulent Y. pestis strain, in a mouse model of bubonic plague. This protection significantly correlated with the in vitro neutralizing activity of the antisera but not with their corresponding ELISA titers. In actively immunized mice, a cutoff value for serum neutralizing activity, above which survival was assured with high degree of confidence, could be established for different vaccination regimes. The impact of overall findings on the potential use of serum neutralizing activity as a correlate of protective immunity is discussed.

Comparative performance of a licensed anthrax vaccine versus electroporation based delivery of a PA encoding DNA vaccine in rhesus macaques.

PubMed

Livingston, Brian D; Little, Stephen F; Luxembourg, Alain; Ellefsen, Barry; Hannaman, Drew

2010-01-22

DNA vaccination is a promising immunization strategy that could be applied in the development of vaccines for a variety of prophylactic and therapeutic indications. Utilizing anthrax protective antigen as a model antigen, we demonstrate that electroporation mediated delivery enhanced the immunogenicity of DNA vaccines in nonhuman primates over 100-fold as compared to conventional intramuscular injection. Two administrations of a DNA vaccine with electroporation elicited anthrax toxin neutralizing antibody responses in 100% of rhesus macaques. Toxin neutralizing antibodies were sustained for the nearly 1-year study duration and were correlated with protection against subsequent lethal Bacillus anthracis spore challenge. Collectively, electroporation mediated DNA vaccination conferred protection comparable to that observed following vaccination with an FDA approved anthrax vaccine.

Commercialization of University Research for Technology-Based Economic Development

ERIC Educational Resources Information Center

Ferguson, W. Ker

2011-01-01

This empirical study investigates the hypothesized relationship between US federally funded university research and development (R&D) and its resulting economic impact, as measured by the level of licensing revenue generated by US universities. The author also examines the key operating statistics of the top-ten licensing income-producing…

77 FR 65698 - Prospective Grant of Exclusive Evaluation Option License: Pre-clinical Evaluation of Human...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-30

... diseases. Upon expiration or termination of the exclusive evaluation option license, MEDICENNA will have...-death related consequences of various diseases and injuries. This technology could be used to minimize or prevent apoptotic damage that can be caused by neurodegenerative disorders, e.g., Alzheimer's...

77 FR 31859 - Government-Owned Inventions; Availability for Licensing

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-30

... licensing in the U.S. in accordance with 35 U.S.C. 207 to achieve expeditious commercialization of results... different tilt angles relative to the electron beam are aligned to compensate for mechanical errors of the... into cancer patients. The instant technology includes CAR constructs with one of three different...

78 FR 7818 - Request To Amend a License To Export Radioactive Waste

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-04

... NUCLEAR REGULATORY COMMISSION Request To Amend a License To Export Radioactive Waste Pursuant to 10 CFR 110.70 (b) ``Public Notice of Receipt of an Application,'' please take notice that the Nuclear... Recipient country application no.; docket No. Eastern Technologies, Inc.; Class A radioactive The total...

37 CFR 401.12 - Licensing of background patent rights to third parties.

Code of Federal Regulations, 2010 CFR

2010-07-01

... SECRETARY FOR TECHNOLOGY POLICY, DEPARTMENT OF COMMERCE RIGHTS TO INVENTIONS MADE BY NONPROFIT ORGANIZATIONS AND SMALL BUSINESS FIRMS UNDER GOVERNMENT GRANTS, CONTRACTS, AND COOPERATIVE AGREEMENTS § 401.12 Licensing of background patent rights to third parties. (a) A funding agreement with a small business firm...

QUANTIFYING INDOOR MOLDS

EPA Science Inventory

The US EPA has patented a mold ID technology (#6,387,652) licensed by 15 companies in the US and EU. This technology is based upon DNA sequences. In conjunction with HUD, this technology will be used in a National Survey of Homes.

Sandia National Laboratories: Sandia National Laboratories: Missions:

Science.gov Websites

; Security Weapons Science & Technology Defense Systems & Assessments About Defense Systems & ; Development Technology Deployment Centers Working With Sandia Working With Sandia Prospective Suppliers What Information Construction & Facilities Contract Audit Sandia's Economic Impact Licensing & Technology

Sandia National Laboratories: National Security Missions: International

Science.gov Websites

; Security Weapons Science & Technology Defense Systems & Assessments About Defense Systems & ; Development Technology Deployment Centers Working With Sandia Working With Sandia Prospective Suppliers What Information Construction & Facilities Contract Audit Sandia's Economic Impact Licensing & Technology

78 FR 73897 - SHINE Medical Technologies, Inc.

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-09

... NUCLEAR REGULATORY COMMISSION [Docket No. 50-608; NRC-2013-0053] SHINE Medical Technologies, Inc. AGENCY: Nuclear Regulatory Commission. ACTION: License application; docketing. SUMMARY: The U.S. Nuclear... construction permit, submitted by SHINE Medical Technologies, Inc. (SHINE) is acceptable for docketing...

Defect-free fabrication of nano-disk and nano-wire by fusion of bio-template and neutral beam etching

NASA Astrophysics Data System (ADS)

Samukawa, S.; Noda, Shuichi; Higo, Akio; Yasuda, Manabu; Wada, Kazumi

2016-11-01

We have developed an innovated fabrication technology of Si, GaAs, and Ge nano-structures, i.e., we called defect-free neutral beam etching. The technology has been successfully applied to prototype the quantum nano-disks and nano-wires with ferritin based bio-templates. SEM observation verifies that the designed structures are prototyped. Photoluminescence measurements demonstrates high optical quality of nano-structures based on the technology.

Options for Technology Transfer.

ERIC Educational Resources Information Center

Anderson, Richard E.; Sugarman, Barry

1989-01-01

Structural means by which institutions of higher education can tap technology are explored with an examination of the licensing of technological discoveries as well as the creation of start-up companies based upon university-developed technology. Additionally, the corporate structures that are being formed so that institutions can more easily hold…

Cytomegalovirus neutralization by hyperimmune and standard intravenous immunoglobulin preparations.

PubMed

Planitzer, Christina B; Saemann, Marcus D; Gajek, Hartwig; Farcet, Maria R; Kreil, Thomas R

2011-08-15

Cytomegalovirus (CMV) remains one of the most important pathogens after transplantation, potentially leading to CMV disease, allograft dysfunction, acute, and chronic rejection and opportunistic infections. Immunoglobulin G (IgG) preparations with high antibody titers against CMV are a valuable adjunctive prevention and treatment option for clinicians and apart from standard intravenous immunoglobulin (IVIG), CMV hyperimmune preparations are available. The CMV antibody titer of these preparations is typically determined by Enzyme-linked immunosorbent assay (ELISA), also used for the selection of high titer plasma donors for the production of the CMV Hyperimmune product. However, CMV ELISA titers do not necessarily correlate with CMV antibody function which is determined by virus neutralization tests. CMV antibody titers were determined by both ELISA and virus neutralization assay and the IgG subclass distribution was compared between a CMV hyperimmune licensed in Europe and standard IVIG preparations. Although the expected high CMV IgG ELISA antibody titers were confirmed for three lots of a CMV hyperimmune preparation, the functionally more relevant CMV neutralizing antibody titers were significantly higher for 31 lots of standard IVIG preparations. Moreover, considerably lower IgG3 levels were found for the CMV hyperimmune preparation compared with standard IVIG preparations. The higher functional CMV neutralization titers of standard IVIG preparations and the better availability of these preparations, suggest that these products could be a valuable alternative to the CMV hyperimmune preparation.

75 FR 18826 - Notice of Inventions Available for License

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-13

..., Office of the Assistant General Counsel for Technology Transfer and Intellectual Property, U.S..., 2010. Paul A. Gottlieb, Assistant General Counsel for Technology, Transfer and Intellectual Property...

Eating on Demand

NASA Technical Reports Server (NTRS)

1998-01-01

Under subcontract to McDonnell-Douglas Corporation, Enersyst Development Center developed air impingement technology through oven designs for NASA's Space Station Freedom. Jets of hot air at the top and bottom of the oven are focused on the food, rather than heating the oven cavity as in a traditional thermal oven. By heating the food directly, foods cook faster and more consistently, retaining flavor and texture. Several companies have licensed this technology, including KRh Thermal Systems, which has introduced a line of Hot Choice vending machines. Enersyst has also licensed the first home application to Thermador.

Chinese License Plates Recognition Method Based on A Robust and Efficient Feature Extraction and BPNN Algorithm

NASA Astrophysics Data System (ADS)

Zhang, Ming; Xie, Fei; Zhao, Jing; Sun, Rui; Zhang, Lei; Zhang, Yue

2018-04-01

The prosperity of license plate recognition technology has made great contribution to the development of Intelligent Transport System (ITS). In this paper, a robust and efficient license plate recognition method is proposed which is based on a combined feature extraction model and BPNN (Back Propagation Neural Network) algorithm. Firstly, the candidate region of the license plate detection and segmentation method is developed. Secondly, a new feature extraction model is designed considering three sets of features combination. Thirdly, the license plates classification and recognition method using the combined feature model and BPNN algorithm is presented. Finally, the experimental results indicate that the license plate segmentation and recognition both can be achieved effectively by the proposed algorithm. Compared with three traditional methods, the recognition accuracy of the proposed method has increased to 95.7% and the consuming time has decreased to 51.4ms.

University Technology Transfer Information Processing from the Attention Based View

ERIC Educational Resources Information Center

Hamilton, Clovia

2015-01-01

Between 2005 and 2011, there was no substantial growth in licenses executed by university technology transfer offices. Since the passage of the Bayh Dole Act of 1980, universities have owned technological inventions afforded by federal research funding. There are still university technology transfer offices that struggle with increasing their…

ELI/SBP'S UVB (VACUUM VAPORIZATION WELL) SYSTEM FOR TREATMENT OF VOC-CONTAMINATED SOILS; INNOVATIVE TECHNOLOGY EVALUATION REPORT

EPA Science Inventory

This report summarizes the findings of an evaluation of the Unterdruck-Verdampfer-Brunnen (UVB) technology developed by IEG Technologies (IEG) and licensed in the eastern United States by Environmental Laboratories, Inc. (ELI) and SBP Technologies (SBP). This evaluation was cond...

EPA-developed, patented technologies related to vehicles and fuel emissions

EPA Pesticide Factsheets

Under the Federal Technology Transfer Act (FTTA), Federal Agencies can patent inventions developed during the course of research. These technologies can then be licensed to businesses or individuals for further development and sale in the marketplace. These technologies primarily relate to efficient vehicle systems and hybrid or diesel engines.

Lagrangian Coherent Structures in Tropical Cyclone Intensification

DTIC Science & Technology

2011-09-21

the system -scale circulation.20 1For reference, the connection between the moist entropy (s) and θe is s=cp ln(θe), where cp is the specific heat of...of sensible heat, moisture, and momentum between the atmosphere and the ocean . The model calcu- lations were initialized using a convectively neutral...acpd-11-1-2011 © Author(s) 2011. CC Attribution 3.0 License. Atmospheric Chemistry and Physics Discussions This discussion paper is/has been under

31 CFR 538.519 - Aircraft and maritime safety.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Aircraft and maritime safety. 538.519..., Authorizations, and Statements of Licensing Policy § 538.519 Aircraft and maritime safety. Specific licenses may... technology to insure the safety of civil aviation and safe operation of U.S.-origin commercial passenger...

77 FR 8880 - Agency Information Collection Activities; Proposed Collection; Comment Request; General Licensing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-15

... Provisions; Section 351(k) Biosimilar Applications AGENCY: Food and Drug Administration, HHS. ACTION: Notice... of information technology. General Licensing Provisions; Section 351(K) Biosimilar Applications On... Affordable Care Act.) Section 351(k) of the PHS Act (42 U.S.C. 262(k)), added by the BPCI Act, sets forth the...

Critical Resource Effects on America's Universities: What's behind the Growing Entrepreneurial Orientation?

ERIC Educational Resources Information Center

Powers, Joshua B.

The purpose of this study was to investigate the effects of critical resource flows on technology transfer activity. The investigation focused on the impact on a university's licensing orientation of four sources of research and development (R&D) revenues: federal, state, industry, and institutional. By licensing orientation is meant the…

78 FR 11164 - Intent To Grant an Exclusive License of U.S. Government-Owned Invention

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-15

... Specificities to Protein and Lipid Epitopes,'' to Avanti Polar Lipids with its principal place of business at 700 Industrial Park Drive, Alabaster, AL 35007. ADDRESSES: Commander, U.S. Army Medical Research and... FURTHER INFORMATION CONTACT: For licensing issues, Dr. Paul Mele, Office of Research & Technology...

Efficient Method of Achieving Agreements between Individuals and Organizations about RFID Privacy

NASA Astrophysics Data System (ADS)

Cha, Shi-Cho

This work presents novel technical and legal approaches that address privacy concerns for personal data in RFID systems. In recent years, to minimize the conflict between convenience and the privacy risk of RFID systems, organizations have been requested to disclose their policies regarding RFID activities, obtain customer consent, and adopt appropriate mechanisms to enforce these policies. However, current research on RFID typically focuses on enforcement mechanisms to protect personal data stored in RFID tags and prevent organizations from tracking user activity through information emitted by specific RFID tags. A missing piece is how organizations can obtain customers' consent efficiently and flexibly. This study recommends that organizations obtain licenses automatically or semi-automatically before collecting personal data via RFID technologies rather than deal with written consents. Such digitalized and standard licenses can be checked automatically to ensure that collection and use of personal data is based on user consent. While individuals can easily control who has licenses and license content, the proposed framework provides an efficient and flexible way to overcome the deficiencies in current privacy protection technologies for RFID systems.

15 CFR 750.3 - Review of license applications by BIS and other government agencies and departments.

Code of Federal Regulations, 2013 CFR

2013-01-01

... items controlled for national security, missile technology, nuclear nonproliferation, and chemical and... primarily with items controlled for national security, nuclear nonproliferation, missile technology...

15 CFR 750.3 - Review of license applications by BIS and other government agencies and departments.

Code of Federal Regulations, 2012 CFR

2012-01-01

... items controlled for national security, missile technology, nuclear nonproliferation, and chemical and... primarily with items controlled for national security, nuclear nonproliferation, missile technology...

15 CFR 750.3 - Review of license applications by BIS and other government agencies and departments.

Code of Federal Regulations, 2014 CFR

2014-01-01

... items controlled for national security, missile technology, nuclear nonproliferation, and chemical and... primarily with items controlled for national security, nuclear nonproliferation, missile technology...

Technology Licensing to Non-Traditional Partners: Non-Profit Health Product Development Organizations for Better Global Health

ERIC Educational Resources Information Center

Gardner, Charles; Garner, Cathy

2005-01-01

The commercialization of technologies arising from university research depends on the ability of technology managers to find and contract with appropriate development partners. Substantial investment is required to bring new health-science technologies to market, and when such technologies appear to have limited commercial markets it can be…

Optical/digital identification/verification system based on digital watermarking technology

NASA Astrophysics Data System (ADS)

Herrigel, Alexander; Voloshynovskiy, Sviatoslav V.; Hrytskiv, Zenon D.

2000-06-01

This paper presents a new approach for the secure integrity verification of driver licenses, passports or other analogue identification documents. The system embeds (detects) the reference number of the identification document with the DCT watermark technology in (from) the owner photo of the identification document holder. During verification the reference number is extracted and compared with the reference number printed in the identification document. The approach combines optical and digital image processing techniques. The detection system must be able to scan an analogue driver license or passport, convert the image of this document into a digital representation and then apply the watermark verification algorithm to check the payload of the embedded watermark. If the payload of the watermark is identical with the printed visual reference number of the issuer, the verification was successful and the passport or driver license has not been modified. This approach constitutes a new class of application for the watermark technology, which was originally targeted for the copyright protection of digital multimedia data. The presented approach substantially increases the security of the analogue identification documents applied in many European countries.

78 FR 66078 - National Institute of Standards and Technology, Gaithersburg, Maryland

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-04

... and Technology, Gaithersburg, Maryland AGENCY: Nuclear Regulatory Commission. ACTION: Notice of... Standards and Technology (NIST), which uses licensed materials for research, development, calibration, and testing activities. ADDRESSES: Please refer to Docket ID NRC-2012-0091 when contacting the NRC about the...

University Technology Transfer Factors as Predictors of Entrepreneurial Orientation

ERIC Educational Resources Information Center

Kirkman, Dorothy M.

2011-01-01

University technology transfer is a collaborative effort between academia and industry involving knowledge sharing and learning. Working closely with their university partners affords biotechnology firms the opportunity to successfully develop licensed inventions and gain access to novel scientific and technological discoveries. These factors may…

78 FR 17187 - Notice of Intent To Grant Exclusive Patent License; Fiber Optic Sensor Systems Technology...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-20

...; Fiber Optic Sensor Systems Technology Corporation AGENCY: Department of the Navy, DoD. ACTION: Notice..., 2012, announcing an intent to grant to Fiber Optic Sensor Systems Technology Corporation, a revocable... the Navy hereby gives notice of its intent to grant to Fiber Optic Sensor Systems Technology...

Second Annual Technology Showcase Fosters Camaraderie and Collaboration | Poster

Cancer.gov

“Collaboration” was the word of the day at the second annual Technology Showcase, held June 13 at the Advanced Technology Research Facility (ATRF). Hundreds of science and business professionals gathered to network and learn about technologies at the National Cancer Institute (NCI) and Frederick National Laboratory that are available for licensing and partnering.

Evaluation of the Potency, Neutralizing Antibody Response, and Stability of a Recombinant Fusion Protein Vaccine for Streptococcus pyogenes.

PubMed

Burlet, E; HogenEsch, H; Dunham, A; Morefield, G

2017-05-01

Streptococcus pyogenes or group A streptococcus (GAS) is a Gram-positive bacterium that can cause a wide range of diseases, including pharyngitis, impetigo, scarlet fever, necrotizing fasciitis, rheumatic fever, and streptococcal toxic shock syndrome. Despite the increasing burden on global health caused by GAS, there is currently no licensed vaccine available. In this study, we evaluated immunogenicity, induction of neutralizing antibodies, and stability of a new recombinant fusion protein vaccine that targets infections from GAS. The recombinant fusion protein (SpeAB) combines inactive mutant forms of streptococcal pyrogenic exotoxin A (SpeA) and streptococcal pyrogenic exotoxin B (SpeB). The SpeAB vaccine evaluated in this study was adsorbed to an aluminum adjuvant and demonstrated robust immunogenicity, eliciting production of specific neutralizing antibodies against SpeA and SpeB, two major virulence factors of S. pyogenes. Stability studies suggest that the vaccine will retain immunogenicity for at least 2 years when stored at refrigerated temperatures. This novel vaccine shows great potential to provide protection against GAS infections and to reduce the burden of GAS disease globally.

Generation of a recombinant West Nile virus stably expressing the Gaussia luciferase for neutralization assay.

PubMed

Zhang, Pan-Tao; Shan, Chao; Li, Xiao-Dan; Liu, Si-Qing; Deng, Cheng-Lin; Ye, Han-Qing; Shang, Bao-Di; Shi, Pei-Yong; Lv, Ming; Shen, Bei-Fen; Qin, Cheng-Feng; Zhang, Bo

2016-01-04

West Nile virus (WNV) is a neurotropic human pathogen that has caused increasing infected cases over recent years. There is currently no licensed vaccine or effective drug for prevention and treatment of WNV infection in humans. To facilitate antiviral drug discovery and neutralizing antibody detection, a WNV cDNA clone containing a luciferase reporter gene was constructed through incorporating Gaussia luciferase (Gluc) gene within the capsid-coding region of WNV genome. Transfection of BHK-21 cells with the cDNA clone-derived RNA generated luciferase reporter WNV (WNV-Gluc) and the stable WNV-Gluc with high titers (>10(7)PFU/ml) was obtained through plaque purification. Luciferase activity was used to effectively quantify the viral production of WNV-Gluc. Using the reporter virus WNV-Gluc, we developed a luciferase based assay in a 12-well format for evaluating neutralizing antibodies. The reporter virus could be a powerful tool for epidemiological investigation of WNV, vaccine evaluation, antiviral drug screening, and the study of WNV replication and pathogenesis. Copyright © 2015 Elsevier B.V. All rights reserved.

Current status of Zika vaccine development: Zika vaccines advance into clinical evaluation.

PubMed

Barrett, Alan D T

2018-01-01

Zika virus (ZIKV), a mosquito-borne flavivirus, was first identified in the 1940s in Uganda in Africa and emerged in the Americas in Brazil in May 2015. In the 30 months since ZIKV emerged as a major public health problem, spectacular progress has been made with vaccine development cumulating with the publication of three reports of phase 1 clinical trials in the 4th quarter of 2017. Clinical trials involving candidate DNA and purified inactivated virus vaccines showed all were safe and well-tolerated in the small number of volunteers and all induced neutralizing antibodies, although these varied by vaccine candidate and dosing regimen. These results suggest that a Zika vaccine can be developed and that phase 2 clinical trials are warranted. However, it is difficult to compare the results from the different phase 1 studies or with neutralizing antibodies induced by licensed flavivirus vaccines (Japanese encephalitis, tick-borne encephalitis, and yellow fever) as neutralizing antibody assays vary and, unfortunately, there are no standards for Zika virus neutralizing antibodies. In addition to clinical studies, substantial progress continues to be made in nonclinical development, particularly in terms of the ability of candidate vaccines to protect reproductive tissues, and the potential use of monoclonal antibodies for passive prophylaxis.

[Technology transfer between academic laboratories and industrial laboratories: licensing].

PubMed

Salauze, D

2010-09-01

The time when academic and industrial research were operating in two separate worlds is now over. Technology transfer from one to the other is now frequent and organized. It starts by filing a patent. Of course, provided the amounts at stake for developing a product, especially in the healthcare field, a non patent-protected invention has virtually no chance of eventually reaching the community. But this is only the first step of a long process which starts by licensing deals of which we will examine the main common clauses. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

Signal Processing Methods Monitor Cranial Pressure

NASA Technical Reports Server (NTRS)

2010-01-01

Dr. Norden Huang, of Goddard Space Flight Center, invented a set of algorithms (called the Hilbert-Huang Transform, or HHT) for analyzing nonlinear and nonstationary signals that developed into a user-friendly signal processing technology for analyzing time-varying processes. At an auction managed by Ocean Tomo Federal Services LLC, licenses of 10 U.S. patents and 1 domestic patent application related to HHT were sold to DynaDx Corporation, of Mountain View, California. DynaDx is now using the licensed NASA technology for medical diagnosis and prediction of brain blood flow-related problems, such as stroke, dementia, and traumatic brain injury.

Mathematical modeling and pharmaceutical pricing: analyses used to inform in-licensing and developmental go/No-Go decisions.

PubMed

Vernon, John A; Hughen, W Keener; Johnson, Scott J

2005-05-01

In the face of significant real healthcare cost inflation, pressured budgets, and ongoing launches of myriad technology of uncertain value, payers have formalized new valuation techniques that represent a barrier to entry for drugs. Cost-effectiveness analysis predominates among these methods, which involves differencing a new technological intervention's marginal costs and benefits with a comparator's, and comparing the resulting ratio to a payer's willingness-to-pay threshold. In this paper we describe how firms are able to model the feasible range of future product prices when making in-licensing and developmental Go/No-Go decisions by considering payers' use of the cost-effectiveness method. We illustrate this analytic method with a simple deterministic example and then incorporate stochastic assumptions using both analytic and simulation methods. Using this strategic approach, firms may reduce product development and in-licensing risk.

Universities Report More Licensing Income but Fewer Start-Ups in 2005

ERIC Educational Resources Information Center

Blumenstyk, Goldie

2007-01-01

According to a survey conducted by the Association of University Technology Managers, at least two dozen universities each earned more than $10-million from their licensing of rights to new drugs, software, and other inventions in the 2005 fiscal year. The number of institutions creating large numbers of spinoff companies based on their…

75 FR 55576 - Intent To Grant Field of Use Exclusive License to U.S. Government-Owned Patents

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-13

... grant a field of use exclusive, revocable license for the field of prevention and/or therapeutic... patents and patent applications (PCT/ US2001/04520) to Biofactura, Inc., with its principal place of..., Office of Research and Technology Applications (ORTA), (301) 619-6664. For patent issues, Ms. Elizabeth...

Perceptions of Polycom Programming for Delivery of Continuing Education to Florida's Licensed Pesticide Applicators

ERIC Educational Resources Information Center

Fishel, Fred; Ferrell, Jason; Vallad, Gary; Price, Jim; Cherry, Ron; Mizell, Russ; Duncan, Larry

2010-01-01

Polycom technology has potential for efficient use of program delivery by Extension educators. A survey of licensed pesticide applicators attending a 1-day event at one of 20 host polycom sites revealed that polycom distance learning is effective for presenting information and learning. Responses also indicated that most of this audience is…

Pesticide Applicator Profiling: Using Polycom[R] Distance Delivery for Continuing Education and Characterizing Florida's Licensed Applicators

ERIC Educational Resources Information Center

Fishel, Fred; Langeland, Ken

2011-01-01

The University of Florida offers continuing education units (CEUs) via distance technology using Polycom[R] to meet requirements for applicators of pesticides to renew their licenses. A large statewide event conducted in 2010 also included a needs assessment of this group concerning CEUs. Results indicate that these applicators strongly prefer…

22 CFR 126.7 - Denial, revocation, suspension or amendment of licenses and other approvals.

Code of Federal Regulations, 2010 CFR

2010-04-01

... relevant U.S. laws (e.g., the Missile Technology Controls title of the National Defense Authorization Act... a license or other authorization to import defense articles or defense services from, any agency of... manufacturer of the defense article or defense service or any person who has a significant interest in the...

75 FR 16490 - Prospective Grant of Exclusive License: Development of PANVAC and Tumor Associated Antigens as...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-01

... Exclusive License: Development of PANVAC and Tumor Associated Antigens as Cancer Vaccines AGENCY: National... T-cell activation. The patents and patent applications describe a vaccine technology, TRICOM, in... activate both CD4+ and CD8+ T cells. When a TRICOM based vaccine expressing TAAs is administered it greatly...

76 FR 79203 - Prospective Grant of Exclusive License: Veterinary Biological Products for Swine Influenza Vaccines

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-21

... Exclusive License: Veterinary Biological Products for Swine Influenza Vaccines AGENCY: National Institutes....7. The invention relates to compositions and methods of use as Veterinary Influenza Vaccines... to humans. This technology describes DNA vaccines against influenza serotypes H5N1, H1N1, H3N2, and...

15 CFR Appendix E to Part 30 - FTSR to FTR Concordance

Code of Federal Regulations, 2010 CFR

2010-01-01

...) Shipments for use in connection with NASA tracking systems under Office of Export Administration Project... License, RCS NA. 30.55(m) Shipments for use in connection with NOAA operations under the Office of Export Administration General License G-NOAA NA. 30.55(n) Exports of technology and software as defined in 15 CFR 772 of...

15 CFR Appendix E to Part 30 - FTSR to FTR Concordance

Code of Federal Regulations, 2012 CFR

2012-01-01

...) Shipments for use in connection with NASA tracking systems under Office of Export Administration Project... License, RCS NA. 30.55(m) Shipments for use in connection with NOAA operations under the Office of Export Administration General License G-NOAA NA. 30.55(n) Exports of technology and software as defined in 15 CFR 772 of...

15 CFR Appendix E to Part 30 - FTSR to FTR Concordance

Code of Federal Regulations, 2013 CFR

2013-01-01

...) Shipments for use in connection with NASA tracking systems under Office of Export Administration Project... License, RCS NA. 30.55(m) Shipments for use in connection with NOAA operations under the Office of Export Administration General License G-NOAA NA. 30.55(n) Exports of technology and software as defined in 15 CFR 772 of...

15 CFR Appendix E to Part 30 - FTSR to FTR Concordance

Code of Federal Regulations, 2011 CFR

2011-01-01

...) Shipments for use in connection with NASA tracking systems under Office of Export Administration Project... License, RCS NA. 30.55(m) Shipments for use in connection with NOAA operations under the Office of Export Administration General License G-NOAA NA. 30.55(n) Exports of technology and software as defined in 15 CFR 772 of...

15 CFR Appendix E to Part 30 - FTSR to FTR Concordance

Code of Federal Regulations, 2014 CFR

2014-01-01

...) Shipments for use in connection with NASA tracking systems under Office of Export Administration Project... License, RCS NA. 30.55(m) Shipments for use in connection with NOAA operations under the Office of Export Administration General License G-NOAA NA. 30.55(n) Exports of technology and software as defined in 15 CFR 772 of...

JPRS Report, Science & Technology, Europe & Latin America, Argentina: Specifications of ARGOS 380 MW Reactor.

DTIC Science & Technology

1988-02-18

programme. It has a licensing agreement with Siemens AG’s Kraftwerk Union AG, which is its minor shareholder. Under this agreement, ENACE has the...Argentine nuclear programme. It has a licensing agreement with Siemens AG’s Kraftwerk Union AG, which is its minor shareholder. Under this agreement, ENACE

78 FR 21003 - Office of Commercial Space Transportation; Notice of Availability of the Finding of No...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-08

... (ROD) for Issuing Launch and Reentry Licenses to Space Exploration Technologies Corp. (SpaceX) for... to support the issuance of launch and reentry licenses to SpaceX for Falcon 9 and Falcon Heavy commercial launch operations at VAFB. The Proposed Action analyzed in the EA consists of SpaceX operating its...

MOCCASIN: converting MATLAB ODE models to SBML.

PubMed

Gómez, Harold F; Hucka, Michael; Keating, Sarah M; Nudelman, German; Iber, Dagmar; Sealfon, Stuart C

2016-06-15

MATLAB is popular in biological research for creating and simulating models that use ordinary differential equations (ODEs). However, sharing or using these models outside of MATLAB is often problematic. A community standard such as Systems Biology Markup Language (SBML) can serve as a neutral exchange format, but translating models from MATLAB to SBML can be challenging-especially for legacy models not written with translation in mind. We developed MOCCASIN (Model ODE Converter for Creating Automated SBML INteroperability) to help. MOCCASIN can convert ODE-based MATLAB models of biochemical reaction networks into the SBML format. MOCCASIN is available under the terms of the LGPL 2.1 license (http://www.gnu.org/licenses/lgpl-2.1.html). Source code, binaries and test cases can be freely obtained from https://github.com/sbmlteam/moccasin : mhucka@caltech.edu More information is available at https://github.com/sbmlteam/moccasin. © The Author 2016. Published by Oxford University Press.

University-Industry Entrepreneurship: The Organization and Management of American University Technology Transfer Units.

ERIC Educational Resources Information Center

Dill, David D.

1995-01-01

A survey of 289 university technology transfer units investigated their organization, management, and perceived performance effectiveness. Unit types studied included licensing and patent offices, small business development centers, research and technology centers, business facility incubators, and entrepreneurial investment/endowment offices.…

78 FR 47424 - Notice of Intent To Grant Partially Exclusive License

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-05

... Proteins: Balance of Shear Stress and Gravity, NASA Case No. MSC-22859-1 to Technology Applications... be found online at http://technology.nasa.gov/ . Sumara M. Thompson-King, Deputy General Counsel. [FR...

Increase in cellular triacylglycerol content and emergence of large ER-associated lipid droplets in the absence of CDP-DG synthase function.

PubMed

He, Yue; Yam, Candice; Pomraning, Kyle; Chin, Jacqueline S R; Yew, Joanne Y; Freitag, Michael; Oliferenko, Snezhana

2014-12-15

Excess fatty acids and sterols are stored as triacylglycerols and sterol esters in specialized cellular organelles, called lipid droplets. Understanding what determines the cellular amount of neutral lipids and their packaging into lipid droplets is of fundamental and applied interest. Using two species of fission yeast, we show that cycling cells deficient in the function of the ER-resident CDP-DG synthase Cds1 exhibit markedly increased triacylglycerol content and assemble large lipid droplets closely associated with the ER membranes. We demonstrate that these unusual structures recruit the triacylglycerol synthesis machinery and grow by expansion rather than by fusion. Our results suggest that interfering with the CDP-DG route of phosphatidic acid utilization rewires cellular metabolism to adopt a triacylglycerol-rich lifestyle reliant on the Kennedy pathway. © 2014 He, Yam, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

LabKey Server NAb: A tool for analyzing, visualizing and sharing results from neutralizing antibody assays

PubMed Central

2011-01-01

Background Multiple types of assays allow sensitive detection of virus-specific neutralizing antibodies. For example, the extent of antibody neutralization of HIV-1, SIV and SHIV can be measured in the TZM-bl cell line through the degree of luciferase reporter gene expression after infection. In the past, neutralization curves and titers for this standard assay have been calculated using an Excel macro. Updating all instances of such a macro with new techniques can be unwieldy and introduce non-uniformity across multi-lab teams. Using Excel also poses challenges in centrally storing, sharing and associating raw data files and results. Results We present LabKey Server's NAb tool for organizing, analyzing and securely sharing data, files and results for neutralizing antibody (NAb) assays, including the luciferase-based TZM-bl NAb assay. The customizable tool supports high-throughput experiments and includes a graphical plate template designer, allowing researchers to quickly adapt calculations to new plate layouts. The tool calculates the percent neutralization for each serum dilution based on luminescence measurements, fits a range of neutralization curves to titration results and uses these curves to estimate the neutralizing antibody titers for benchmark dilutions. Results, curve visualizations and raw data files are stored in a database and shared through a secure, web-based interface. NAb results can be integrated with other data sources based on sample identifiers. It is simple to make results public after publication by updating folder security settings. Conclusions Standardized tools for analyzing, archiving and sharing assay results can improve the reproducibility, comparability and reliability of results obtained across many labs. LabKey Server and its NAb tool are freely available as open source software at http://www.labkey.com under the Apache 2.0 license. Many members of the HIV research community can also access the LabKey Server NAb tool without installing the software by using the Atlas Science Portal (https://atlas.scharp.org). Atlas is an installation of LabKey Server. PMID:21619655

Advanced Education and Technology Business Plan, 2010-13

ERIC Educational Resources Information Center

Alberta Advanced Education and Technology, 2010

2010-01-01

This paper presents the business plan of the Ministry of Advanced Education and Technology for 2010 to 2013. Advanced Education and Technology supports the advanced learning system by providing funding for advanced learning providers, coordinating and approving programs of study at public institutions, licensing and approving programs at private…

75 FR 68629 - Massachusetts Institute of Technology Reactor Notice of Issuance of Renewed Facility Operating...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-08

... NUCLEAR REGULATORY COMMISSION [Docket No. 50-020; NRC-2010-0313] Massachusetts Institute of Technology Reactor Notice of Issuance of Renewed Facility Operating; License No. R-37 The U.S. Nuclear... Institute of Technology (the licensee), which authorizes continued operation of the Massachusetts Institute...

77 FR 68752 - Notice of Intent To Grant Exclusive License Between National Energy Technology Laboratory and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-16

... Technology Laboratory and Corrosion Solutions AGENCY: National Energy Technology Laboratory, Department of... diffusion coating to a metallic alloy,'' to Corrosion Solutions having its principal place of business in... for filing written objections. Corrosion Solutions, a new small business, has applied for an exclusive...

15 CFR 742.13 - Communications intercepting devices; software and technology for communications intercepting...

Code of Federal Regulations, 2013 CFR

2013-01-01

...; software and technology for communications intercepting devices. 742.13 Section 742.13 Commerce and Foreign... Communications intercepting devices; software and technology for communications intercepting devices. (a) License... wire, oral, or electronic communications (ECCNs 5A001.i and 5A980); and for related “software...

15 CFR Appendix 2 to Part 960 - Fact Sheet Regarding the Memorandum of Understanding Concerning the Licensing of Private Remote...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Fact Sheet Regarding the Memorandum of... to Part 960—Fact Sheet Regarding the Memorandum of Understanding Concerning the Licensing of Private Remote Sensing Satellite Systems Dated February 2, 2000 The White House, Office of Science and Technology...

15 CFR Appendix 2 to Part 960 - Fact Sheet Regarding the Memorandum of Understanding Concerning the Licensing of Private Remote...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Fact Sheet Regarding the Memorandum of... to Part 960—Fact Sheet Regarding the Memorandum of Understanding Concerning the Licensing of Private Remote Sensing Satellite Systems Dated February 2, 2000 The White House, Office of Science and Technology...

15 CFR Appendix 2 to Part 960 - Fact Sheet Regarding the Memorandum of Understanding Concerning the Licensing of Private Remote...

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 3 2012-01-01 2012-01-01 false Fact Sheet Regarding the Memorandum of... to Part 960—Fact Sheet Regarding the Memorandum of Understanding Concerning the Licensing of Private Remote Sensing Satellite Systems Dated February 2, 2000 The White House, Office of Science and Technology...

15 CFR Appendix 2 to Part 960 - Fact Sheet Regarding the Memorandum of Understanding Concerning the Licensing of Private Remote...

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 3 2013-01-01 2013-01-01 false Fact Sheet Regarding the Memorandum of... to Part 960—Fact Sheet Regarding the Memorandum of Understanding Concerning the Licensing of Private Remote Sensing Satellite Systems Dated February 2, 2000 The White House, Office of Science and Technology...

15 CFR Appendix 2 to Part 960 - Fact Sheet Regarding the Memorandum of Understanding Concerning the Licensing of Private Remote...

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 3 2014-01-01 2014-01-01 false Fact Sheet Regarding the Memorandum of... to Part 960—Fact Sheet Regarding the Memorandum of Understanding Concerning the Licensing of Private Remote Sensing Satellite Systems Dated February 2, 2000 The White House, Office of Science and Technology...

Science and Technology in Japan -- A Brief Analytic Survey

DTIC Science & Technology

1975-11-01

international cross- licensing agreements, participation in international joint research efforts, and the growing list of Japanese scientific and...licensing has also increased, and Japanese companies have undertaken joint research with U.S. companies. There have been a few well-publicized... joint ventures, and market restrictions on the licensee may become increasingly onerous. One detects a reluctance among some U.S. companies to

Automatic license plate reader: a solution to avoiding vehicle pursuit

NASA Astrophysics Data System (ADS)

Jordan, Stanley K.

1997-01-01

The Massachusetts Governor's Auto Theft Strike Force has tested an automatic license plate reader (LPR) to recover stolen cars and catch car thieves, without vehicle pursuit. Experiments were conducted at the Sumner Tunnel in Boston, and proved the feasibility of a LPR for identifying stolen cars instantly. The same technology can be applied to other law-enforcement objectives.

Department of the Air Force Information Technology Program FY 95 President’s Budget

DTIC Science & Technology

1994-03-01

2095 2200 552 900 1032 Description: Contractor hardware maintenan support, systems analyst support software development and maintenance, and off -the...hardware maintenance support, systems analyst support, operations support, configuration management, test support, and off -the-shelf software license...2419 2505 2594 Description: Contractor hardware maintenance support, systems analyst support, operations support, and off -the-shelf software license

Spatial service delivery system for smart licensing & enforcement management

NASA Astrophysics Data System (ADS)

Wahap, N. A.; Ismail, N. M.; Nor, N. M.; Ahmad, N.; Omar, M. F.; Termizi, A. A. A.; Zainal, D.; Noordin, N. M.; Mansor, S.

2016-06-01

Spatial information has introduced a new sense of urgency for a better understanding of the public needs in term of what, when and where they need services and through which devices, platform or physical locations they need them. The objective of this project is to value- add existing license management process for business premises which comes under the responsibility of Local Authority (PBT). Manipulation of geospatial and tracing technology via mobile platform allows enforcement officers to work in real-time, use a standardized system, improve service delivery, and optimize operation management. This paper will augment the scope and capabilities of proposed concept namely, Smart Licensing/Enforcement Management (SLEm). It will review the current licensing and enforcement practice of selected PBT in comparison to the enhanced method. As a result, the new enhanced system is expected to offer a total solution for licensing/enforcement management whilst increasing efficiency and transparency for smart city management and governance.

NASA Technology Transfer System

NASA Technical Reports Server (NTRS)

Tran, Peter B.; Okimura, Takeshi

2017-01-01

NTTS is the IT infrastructure for the Agency's Technology Transfer (T2) program containing 60,000+ technology portfolio supporting all ten NASA field centers and HQ. It is the enterprise IT system for facilitating the Agency's technology transfer process, which includes reporting of new technologies (e.g., technology invention disclosures NF1679), protecting intellectual properties (e.g., patents), and commercializing technologies through various technology licenses, software releases, spinoffs, and success stories using custom built workflow, reporting, data consolidation, integration, and search engines.

Progress and Challenges toward the Development of Vaccines against Avian Infectious Bronchitis

PubMed Central

Bande, Faruku; Arshad, Siti Suri; Hair Bejo, Mohd; Moeini, Hassan; Omar, Abdul Rahman

2015-01-01

Avian infectious bronchitis (IB) is a widely distributed poultry disease that has huge economic impact on poultry industry. The continuous emergence of new IBV genotypes and lack of cross protection among different IBV genotypes have been an important challenge. Although live attenuated IB vaccines remarkably induce potent immune response, the potential risk of reversion to virulence, neutralization by the maternal antibodies, and recombination and mutation events are important concern on their usage. On the other hand, inactivated vaccines induce a weaker immune response and may require multiple dosing and/or the use of adjuvants that probably have potential safety risks and increased economic burdens. Consequently, alternative IB vaccines are widely sought. Recent advances in recombinant DNA technology have resulted in experimental IB vaccines that show promise in antibody and T-cells responses, comparable to live attenuated vaccines. Recombinant DNA vaccines have also been enhanced to target multiple serotypes and their efficacy has been improved using delivery vectors, nanoadjuvants, and in ovo vaccination approaches. Although most recombinant IB DNA vaccines are yet to be licensed, it is expected that these types of vaccines may hold sway as future vaccines for inducing a cross protection against multiple IBV serotypes. PMID:25954763

Sustainability Through Technology Licensing and Commercialization: Lessons Learned from the TRIAD Project

PubMed Central

Payne, Philip R.O.

2014-01-01

Ongoing transformation relative to the funding climate for healthcare research programs housed in academic and non-profit research organizations has led to a new (or renewed) emphasis on the pursuit of non-traditional sustainability models. This need is often particularly acute in the context of data management and sharing infrastructure that is developed under the auspices of such research initiatives. One option for achieving sustainability of such data management and sharing infrastructure is the pursuit of technology licensing and commercialization, in an effort to establish public-private or equivalent partnerships that sustain and even expand upon the development and dissemination of research-oriented data management and sharing technologies. However, the critical success factors for technology licensing and commercialization efforts are often unknown to individuals outside of the private sector, thus making this type of endeavor challenging to investigators in academic and non-profit settings. In response to such a gap in knowledge, this article will review a number of generalizable lessons learned from an effort undertaken at The Ohio State University to commercialize a prototypical research-oriented data management and sharing infrastructure, known as the Translational Research Informatics and Data Management (TRIAD) Grid. It is important to note that the specific emphasis of these lessons learned is on the early stages of moving a technology from the research setting into a private-sector entity and as such are particularly relevant to academic investigators interested in pursuing such activities. PMID:25848609

Squalene-containing licensed adjuvants enhance strain-specific antibody responses against the influenza hemagglutinin and induce subtype-specific antibodies against the neuraminidase.

PubMed

Schmidt, Rebecca; Holznagel, Edgar; Neumann, Britta; Alex, Nina; Sawatsky, Bevan; Enkirch, Theresa; Pfeffermann, Kristin; Kruip, Carina; von Messling, Veronika; Wagner, Ralf

2016-10-17

While seasonal influenza vaccines are usually non-adjuvanted, H1N1pdm09 vaccines were formulated with different squalene-containing adjuvants, to enable the reduction of antigen content thus increasing the number of doses available. To comparatively assess the effects of these adjuvants on antibody responses against matched and mismatched strains, and to correlate antibody levels with protection from disease, ferrets were immunized with 2μg of commercial H1N1pdm09 vaccine antigen alone or formulated with different licensed adjuvants. The use of squalene-containing adjuvants increased neutralizing antibody responses around 100-fold, and resulted in a significantly reduced viral load after challenge with a matched strain. While all animals mounted strong total antibody responses against the homologous H1N1 hemagglutinin (HA) protein, which correlated with the respective neutralizing antibody titers, no reactivity with the divergent H3, H5, H7, and H9 proteins were detected. Only the adjuvanted vaccines also induced antibodies against the neuraminidase (NA) protein, which were able to also recognize NA proteins from other N1 carrying strains. These findings not only support the use of squalene-containing adjuvants in dose-sparing strategies but also support speculations that the induction of NA-specific responses associated with the use of these adjuvants may confer partial protection to heterologous strains carrying the same NA subtype. Copyright © 2016 Elsevier Ltd. All rights reserved.

Investigating RFID for Roadside Identification Involving Freight Commercial Vehicle Operators

DOT National Transportation Integrated Search

2010-01-01

Radio Frequency Identification (RFID) is an emerging technology to track commercial vehicles. This transcript describes research that investigates the ability for RFID technologies to work in license plates. Mile markers are common fixtures on the ro...

Research Tools and Materials | NCI Technology Transfer Center | TTC

Cancer.gov

Research Tools can be found in TTC's Available Technologies and in scientific publications. They are freely available to non-profits and universities through a Material Transfer Agreement (or other appropriate mechanism), and available via licensing to companies.

A Mobile Health Platform | NCI Technology Transfer Center | TTC

Cancer.gov

Researchers at the National Institute on Drug Abuse (NIDA) seek licensing or co-development of a mobile health technology that monitors and predicts a user’s psychological status in order to deliver an automated intervention when needed.

An assessment of implications of adaptive licensing for pharmaceutical intellectual property and regulatory exclusivity rights in the European Union.

PubMed

Meier, A; Faulkner, S D; Schoonderbeek, C; Jong, B; Kung, J; Brindley, D; Barker, R

2016-12-01

One of the key advantages of adaptive licensing (AL) is to align the licensing of new medicines more closely with patient needs for earlier access to beneficial treatments. From an innovators perspective, "earlier" market access may seem an obvious incentive to gain earlier revenue generation. However, this is offset with an "earlier" start to patent and regulatory protection periods, which, depending on the technology, disease, population, and timing of subsequent asset protection periods, can present a conflict. © 2016 American Society for Clinical Pharmacology and Therapeutics.

Enhanced technologies for unattended ground sensor systems

NASA Astrophysics Data System (ADS)

Hartup, David C.

2010-04-01

Progress in several technical areas is being leveraged to advantage in Unattended Ground Sensor (UGS) systems. This paper discusses advanced technologies that are appropriate for use in UGS systems. While some technologies provide evolutionary improvements, other technologies result in revolutionary performance advancements for UGS systems. Some specific technologies discussed include wireless cameras and viewers, commercial PDA-based system programmers and monitors, new materials and techniques for packaging improvements, low power cueing sensor radios, advanced long-haul terrestrial and SATCOM radios, and networked communications. Other technologies covered include advanced target detection algorithms, high pixel count cameras for license plate and facial recognition, small cameras that provide large stand-off distances, video transmissions of target activity instead of still images, sensor fusion algorithms, and control center hardware. The impact of each technology on the overall UGS system architecture is discussed, along with the advantages provided to UGS system users. Areas of analysis include required camera parameters as a function of stand-off distance for license plate and facial recognition applications, power consumption for wireless cameras and viewers, sensor fusion communication requirements, and requirements to practically implement video transmission through UGS systems. Examples of devices that have already been fielded using technology from several of these areas are given.

R&D Funding Sources and University Technology Transfer: What Is Stimulating Universities to Be More Entrepreneurial?

ERIC Educational Resources Information Center

Powers, Joshua B.

2004-01-01

In recent years, universities have become increasingly entrepreneurial as evidenced by their rapid escalation into technology transfer, the process by which university-developed technologies are commercialized. Stimulated in part by a favorable policy environment for patenting and licensing as well as increased competition for limited resources,…

15 CFR Supplement No. 2 to Part 774 - General Technology and Software Notes

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false General Technology and Software Notes... Software Notes 1. General Technology Note. The export of “technology” that is “required” for the... necessary” information. 2. General Software Note. License Exception TSU (“mass market” software) is...

15 CFR 742.13 - Communications intercepting devices; software and technology for communications intercepting...

Code of Federal Regulations, 2014 CFR

2014-01-01

...; software and technology for communications intercepting devices. 742.13 Section 742.13 Commerce and Foreign... Communications intercepting devices; software and technology for communications intercepting devices. (a) License... wire, oral, or electronic communications (ECCNs 5A001.f.1 and 5A980); and for related “software...

15 CFR Supplement No. 2 to Part 774 - General Technology and Software Notes

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false General Technology and Software Notes... Software Notes 1. General Technology Note. The export of “technology” that is “required” for the... necessary” information. 2. General Software Note. License Exception TSU (“mass market” software) is...

15 CFR Supplement No. 2 to Part 774 - General Technology and Software Notes

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false General Technology and Software Notes... Software Notes 1. General Technology Note. The export of “technology” that is “required” for the... necessary” information. 2. General Software Note. License Exception TSU (“mass market” software) is...

77 FR 42504 - Prospective Grant of Exclusive License: Development of a Diagnostic Tool for Diagnosing Benign...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-19

...: [email protected] . SUPPLEMENTARY INFORMATION: This technology is based on the discovery of... which are received by the NIH Office of Technology Transfer on or before August 20, 2012 will be... and Patenting Manager, Office of Technology Transfer, National Institutes of Health, 6011 Executive...

Characterization of rubella-specific humoral immunity following two doses of MMR vaccine using proteome microarray technology

PubMed Central

Haralambieva, Iana H.; Gibson, Michael J.; Kennedy, Richard B.; Ovsyannikova, Inna G.; Warner, Nathaniel D.; Grill, Diane E.

2017-01-01

Introduction//Background The lack of standardization of the currently used commercial anti-rubella IgG antibody assays leads to frequent misinterpretation of results for samples with low/equivocal antibody concentration. The use of alternative approaches in rubella serology could add new information leading to a fuller understanding of rubella protective immunity and neutralizing antibody response after vaccination. Methods We applied microarray technology to measure antibodies to all rubella virus proteins in 75 high and 75 low rubella virus-specific antibody responders after two MMR vaccine doses. These data were used in multivariate penalized logistic regression modeling of rubella-specific neutralizing antibody response after vaccination. Results We measured antibodies to all rubella virus structural proteins (i.e., the glycoproteins E1 and E2 and the capsid C protein) and to the non-structural protein P150. Antibody levels to each of these proteins were: correlated with the neutralizing antibody titer (p<0.006); demonstrated differences between the high and the low antibody responder groups (p<0.008); and were components of the model associated with/predictive of vaccine-induced rubella virus-specific neutralizing antibody titers (misclassification error = 0.2). Conclusion Our study supports the use of this new technology, as well as the use of antibody profiles/patterns (rather than single antibody measures) as biomarkers of neutralizing antibody response and correlates of protective immunity in rubella virus serology. PMID:29145521

Assessing the effectiveness of technology transfer from U.S. government R&D laboratories: impact of market orientation

NASA Astrophysics Data System (ADS)

Bozeman, Barry; Coker, Karen

1992-05-01

This study, based on a national survey of U.S. government laboratories, assesses the degree of success laboratories have had in transferring technology to industry, taking into account the laboratories' differing receptivity to market influences. Three success criteria are considered here, two based on self-evaluations and a third based on the number of technology licenses issued from the laboratory. The two self-evaluations are rooted in different types of effectiveness, `getting technology out the door,' in one case, and, in the other, having a demonstrable commercial impact. A core hypothesis of the study is that the two types of effectiveness will be responsive to different factors and, in particular, the laboratories with a clearer market orientation will have a higher degree of success on the commercial impact and technology license criteria. Overall, the results seem to suggest that multifaceted, multimission laboratories are likely to enjoy the most success in technology transfer, especially if they have relatively low levels of bureaucratization and either ties to industry (particularly direct financial ties) or a commercial orientation in the selection of projects.

76 FR 75543 - Missisquoi River Technologies; Missisquoi River Hydro LLC; Notice of Transfer of Exemption

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-02

..., Missisquoi River Technologies informed the Commission that its exemption from licensing for the North Troy..., located at 453 East Hill Rd., Middlesex, VT 05602, is now the exemptee of the North Troy Hydroelectric...

78 FR 22529 - Notice of Intent To Grant Partially Exclusive Patent License; Max-Viz, Inc.

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-16

... Technology Applications, Space and Naval Warfare Systems Center Pacific, Code 72120, 53560 Hull St, Bldg A33... Technology Applications, Space and Naval Warfare Systems Center Pacific, Code 72120, 53560 Hull St, Bldg A33...

77 FR 26014 - Prospective Grant of Exclusive License: P4 Peptide From Streptococcus Pneumoniae

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-02

... ``Functional Epitopes of Streptococcus Pneumoniae PsaA Antigen and Uses Thereof,'' filed 7/ 18/2008, claiming.... Technology This technology consists of a P4 peptide which contains functional epitopes of the PsaA protein of...

Pseudo-plaque reduction neutralization test (PPRNT) for the measurement of neutralizing antibodies to Crimean-Congo hemorrhagic fever virus.

PubMed

Canakoglu, Nurettin; Berber, Engin; Ertek, Mustafa; Yoruk, Mustafa D; Tonbak, Sukru; Bolat, Yusuf; Aktas, Munir; Kalkan, Ahmet; Ozdarendeli, Aykut

2013-01-03

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus of the genus Nairovirus family Bunyaviridae, which are enveloped viruses containing tripartite, negative polarity, single-stranded RNA. CCHF is characterized by high case mortality, occurring in Asia, Africa, the Middle East and Europe. Currently, there are no specific treatments or licensed vaccines available for CCHFV. Recently, two research groups have found adult mice with defective interferon responses allowed to lethal CCHFV infection. These mouse models could provide invaluable information for further studies. Efforts to develop a vaccine against CCHFV are being made. To determine the efficacy of vaccine candidates it is important to conduct serological studies that can accurately measure levels of protective antibodies. In the present study, a pseudo-plaque reduction neutralization test (PPRNT) based on enzyme-catalyzed color development of infected cells probed with anti-CCHFV antibodies was used to measure neutralization antibody of CCHFV. Sixty-nine human serum samples (20 acute and 49 convalescent) were tested. The presence of CCHFV antibodies was determined and confirmed by a commercial ELISA kit. CCHFV RNA was determined by RT-PCR. All the samples were analyzed by PPRNT and fluorescent focus reduction neutralization test (FFRNT) to measure of CCHFV-neutralizing antibodies. Pseudo-plaque reduction neutralization test showed a high sensitivity (98%), specificity (100%) and agreement (96,6%) in qualitative comparison with those of the FFRNT. There was a high correlation between the titers obtained in PPRNT and FFRNT (R2 = 0.92). The inter- and intra-assay variation of PPRNT revealed good reproducibility and positive cut-off of PPRNT was defined as 1:4 by the geometric mean titers for the individual samples distributed. The pseudo-plaque reduction neutralization test described in this study is a fast, reproducible and sensitive method for the measurement of CCHF neutralizing antibodies. This novel assay could serve as useful tools for CCHF research in epidemiology, vaccine development and other studies of immunity. It also provides an alternative to PRNT when viruses with no or poor CPE in cell culture.

Pseudo-plaque reduction neutralization test (PPRNT) for the measurement of neutralizing antibodies to Crimean-Congo hemorrhagic fever virus

PubMed Central

2013-01-01

Background Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus of the genus Nairovirus family Bunyaviridae, which are enveloped viruses containing tripartite, negative polarity, single-stranded RNA. CCHF is characterized by high case mortality, occurring in Asia, Africa, the Middle East and Europe. Currently, there are no specific treatments or licensed vaccines available for CCHFV. Recently, two research groups have found adult mice with defective interferon responses allowed to lethal CCHFV infection. These mouse models could provide invaluable information for further studies. Efforts to develop a vaccine against CCHFV are being made. To determine the efficacy of vaccine candidates it is important to conduct serological studies that can accurately measure levels of protective antibodies. In the present study, a pseudo-plaque reduction neutralization test (PPRNT) based on enzyme-catalyzed color development of infected cells probed with anti-CCHFV antibodies was used to measure neutralization antibody of CCHFV. Methods Sixty-nine human serum samples (20 acute and 49 convalescent) were tested. The presence of CCHFV antibodies was determined and confirmed by a commercial ELISA kit. CCHFV RNA was determined by RT-PCR. All the samples were analyzed by PPRNT and fluorescent focus reduction neutralization test (FFRNT) to measure of CCHFV-neutralizing antibodies. Results Pseudo-plaque reduction neutralization test showed a high sensitivity (98%), specificity (100%) and agreement (96,6%) in qualitative comparison with those of the FFRNT. There was a high correlation between the titers obtained in PPRNT and FFRNT (R2 = 0.92). The inter- and intra-assay variation of PPRNT revealed good reproducibility and positive cut-off of PPRNT was defined as 1:4 by the geometric mean titers for the individual samples distributed. Conclusion The pseudo-plaque reduction neutralization test described in this study is a fast, reproducible and sensitive method for the measurement of CCHF neutralizing antibodies. This novel assay could serve as useful tools for CCHF research in epidemiology, vaccine development and other studies of immunity. It also provides an alternative to PRNT when viruses with no or poor CPE in cell culture. PMID:23282186

Cystic Fibrosis Patents: A Case Study of Successful Licensing

PubMed Central

Minear, Mollie A.; Kapustij, Cristina; Boden, Kaeleen; Chandrasekharan, Subhashini; Cook-Deegan, Robert

2013-01-01

From 2006–2010, Duke University’s Center for Public Genomics prepared eight case studies examining the effects of gene patent licensing practices on clinical access to genetic testing for ten clinical conditions. One of these case studies focused on the successful licensing practices employed by the University of Michigan and the Hospital for Sick Children in Toronto for patents covering the CFTR gene and its ΔF508 mutation that causes a majority of cystic fibrosis cases. Since the licensing of these patents has not impeded clinical access to genetic testing, we sought to understand how this successful licensing model was developed and whether it might be applicable to other gene patents. We interviewed four key players who either were involved in the initial discussions regarding the structure of licensing or who have recently managed the licenses and collected related documents. Important features of the licensing planning process included thoughtful consideration of potential uses of the patent; anticipation of future scientific discoveries and technological advances; engagement of relevant stakeholders, including the Cystic Fibrosis Foundation; and using separate licenses for in-house diagnostics versus kit manufacture. These features led to the development of a licensing model that has not only allowed the patent holders to avoid the controversy that has plagued other gene patents, but has also allowed research, development of new therapeutics, and wide-spread dissemination of genetic testing for cystic fibrosis. Although this licensing model may not be applicable to all gene patents, it serves as a model in which gene patent licensing can successfully enable innovation, investment in therapeutics research, and protect intellectual property while respecting the needs of patients, scientists, and public health. PMID:24231943

DOE New Technology: Sharing New Frontiers, April 1, 1993--September 30, 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tamura, A.T.; Henline, D.M.

The purpose of DOE New Technology is to provide information on how to access specific technologies developed through research sponsored by DOE and performed by DOE laboratories or by DOE-contracted researchers. This document describes technologies identified as having potential for commercial applications in addition to a catalog of current patent applications and patents available for licensing from DOE and DOE contractors.

77 FR 34030 - Notice of Intent To Grant Partially Exclusive Patent License; Lumedyne Technologies, Inc.

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-08

... and Technology Applications Space and Naval Warfare Systems Center Pacific, Code 72120, 53560 Hull St... Hull St, Bldg A33 Room 2531, San Diego, CA 92152-5001, telephone 619-553-5118, E-Mail: [email protected

78 FR 32380 - Notice of Intent To Grant Partially Exclusive Patent License; Lumedyne Technologies, Inc.

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-30

... Technology Applications, Space and Naval Warfare Systems Center Pacific, Code 72120, 53560 Hull St., Bldg... Hull St., Bldg. A33 Room 2531, San Diego, CA 92152-5001, telephone 619-553-5118, E-Mail: [email protected

76 FR 33769 - Government-Owned Inventions; Availability for Licensing

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-09

...[alpha]-Targeted Therapy for Diabetes and Obesity Description of Technology: This technology describes... and treatment of diabetes. In obesity, the rapid expansion of adipose tissue outpaces the oxygen... hypoxia in obesity and insulin resistance, investigators at the National Cancer Institute disrupted the...

Neutral Beam Development for the Lockheed Martin Compact Fusion Reactor

NASA Astrophysics Data System (ADS)

Ebersohn, Frans; Sullivan, Regina

2017-10-01

The Compact Fusion Reactor project at Lockheed Martin Skunk Works is developing a neutral beam injection system for plasma heating. The neutral beam plasma source consists of a high current lanthanum hexaboride (LaB6) hollow cathode which drives an azimuthal cusp discharge similar to gridded ion thrusters. The beam is extracted with a set of focusing grids and is then neutralized in a chamber pumped with Titanium gettering. The design, testing, and analyses of individual components are presented along with the most current full system results. The goal of this project is to advance in-house neutral beam expertise at Lockheed Martin to aid in operation, procurement, and development of neutral beam technology. ©2017 Lockheed Martin Corporation. All Rights Reserved.

System catalytic neutralization control of combustion engines waste gases in mining technologies

NASA Astrophysics Data System (ADS)

Korshunov, G. I.; Solnitsev, R. I.

2017-10-01

The paper presents the problems solution of the atmospheric air pollution with the exhaust gases of the internal combustion engines, used in mining technologies. Such engines are used in excavators, bulldozers, dump trucks, diesel locomotives in loading and unloading processes and during transportation of minerals. NOx, CO, CH emissions as the waste gases occur during engine operation, the concentration of which must be reduced to the standard limits. The various methods and means are used for the problem solution, one of which is neutralization based on platinum catalysts. A mathematical model of a controlled catalytic neutralization system is proposed. The simulation results confirm the increase in efficiency at start-up and low engine load and the increase in the catalyst lifetime.

Moving beyond Technological Determinism and Autonomy to Face Our Responsibilities

ERIC Educational Resources Information Center

Vanderburg, Willem H.

2012-01-01

This article shows that technological neutrality, determinism, and autonomy correspond to parts of a spectrum of possible historical relations between societies and their technologies. The spectrum of relations is based on the recognition that as we change technology, technology simultaneously changes us. This reinterpretation compels us to face…

Online Education: A Science and Technology Studies Perspective

ERIC Educational Resources Information Center

Hamilton, Edward C.; Friesen, Norm

2013-01-01

This paper argues that research into the pedagogical value and potential of new technologies is limited by the implicit philosophical perspectives on technology that such research adopts. These perspectives either imbue technologies with inalienable qualities (essentialism) or posit technology as a neutral means for realizing goals defined by…

15 CFR Supplement No. 2 to Part 774 - General Technology and Software Notes

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false General Technology and Software Notes... Software Notes 1. General Technology Note. The export of “technology” that is “required” for the... necessary” information. 2. General Software Note. License Exception TSU (mass market software) (see § 740.13...

Technology transfer opportunities: patent license: electrochemical technique for introducing and redistributing ionic species into the earth

USGS Publications Warehouse

Leinz, Reinhard

1996-01-01

Scientists at the U.S. Geological Survey have expanded applications of the Chim electrode, technology used to perform partial geochemical extractions from soils. Recent applications of the the improved electrode technology show that geochemical extraction efficiencies can be improved by 2 orders of magnitude or better to about 30%.

Report for neutral buoyancy simulations of transfer orbit stage contingency extravehicular activities

NASA Technical Reports Server (NTRS)

Sexton, J. D.

1992-01-01

The transfer orbit stage (TOS) will propel the advanced communications technology satellite (ACTS) from the Space Shuttle to an Earth geosynchronous transfer orbit. Two neutral buoyancy test series were conducted at MSFC to validate the extravehicular activities (EVA) contingency operations for the ACTS/TOS/mission. The results of the neutral buoyancy tests are delineated and a brief history of the TOS EVA program is given.

Towards a human oral vaccine for anthrax: the utility of a Salmonella Typhi Ty21a-based prime boost immunization strategy

PubMed Central

Baillie, Leslie W.J.; Rodriguez, Ana L.; Moore, Stephen; Atkins, Helen S.; Feng, Chiguang; Nataro, James P.; Pasetti, Marcela F.

2008-01-01

We previously demonstrated the ability of an orally administered attenuated Salmonella enterica serovar Typhimurium strain expressing the protective antigen (PA) of Bacillus anthracis to confer protection against lethal anthrax aerosol spore challenge [1]. To extend the utility of this approach to humans we constructed variants of S. enterica serovar Typhi Ty21a, an attenuated typhoid vaccine strain licensed for human use, which expressed and exported PA via two distinct plasmid-based transport systems: the Escherichia coli HlyA haemolysin and the S. Typhi ClyA export apparatus. Murine immunogenicity studies confirmed the ability of these constructs, especially Ty21a expressing the ClyA-PA fusion protein, to stimulate strong PA-specific immune responses following intranasal immunization. These responses were further enhanced by a subsequent boost with either parenterally delivered recombinant PA or the licensed US human alum-adsorbed anthrax vaccine (AVA). Anthrax toxin neutralizing antibody responses using this prime-boost regimen were rapid, vigorous and broad in nature. The results of this study demonstrate the feasibility of employing a mucosal prime with a licensed Salmonella Typhi vaccine strain followed by a parenteral protein boost to stimulate rapid protective immunity against anthrax. PMID:18805452

Application of ASP Technology to Realize the Online Administrative License of the earthquake in Hunan Province

NASA Astrophysics Data System (ADS)

Tang, Hongliang; Kang, Chengxu; Tian, Youping

2018-01-01

Realizing the online handling of administrative approval of earthquakes is an important measure to improve work efficiency and facilitate people’s convenience. Based on the analysis of the characteristics and processes of the administrative licensing in the earthquake industry, this paper proposes an online processing model based on ASP technology and an online processing system based on B/S architecture. This paper presents the design and implementation methods. The application of the system shows that the system is simple in design and full in function, and can be used on mobile platforms such as computers and mobile phones, and has good practicability and forward-lookingness.

Using smart card technology to prevent sales of alcohol to underage persons

DOT National Transportation Integrated Search

2001-07-01

This report documents the results of a demonstration and evaluation project to examine the effectiveness of smart card technology (i.e., magnetic stripe on the driver's license and a card reader system) as a means of providing alcohol retailers with ...

Cancer Inhibitors Isolated from an African Plant | NCI Technology Transfer Center | TTC

Cancer.gov

The National Cancer Institute's Molecular Targets Development Program is seeking parties interested in collaborative research to further develop, evaluate, or commercialize cancer inhibitors isolated from the African plant Phyllanthus englerii. The technology is also available for exclusive or non-exclusive licensing.

Overcoming barriers to ITS : lessons from other technologies : final task E report

DOT National Transportation Integrated Search

1995-12-01

The Task E report involves an analysis of franchises and license agreements for the provision of public services, which is the fourth in a series in the study. Overcoming Barriers to ITS - Lessons from Other Technologies. This report follows alternat...

78 FR 32294 - Escalate Capital Partners SBIC I, L.P., License No. 06/06-0335; Notice Seeking Exemption Under...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-29

..., L.P. proposes to provide loan financing to SailPoint Technologies, Inc., 6034 West Courtyard Drive... Associate of Escalate Capital Partners, SBIC I, L.P., owns more than ten percent of SailPoint Technologies...

78 FR 26656 - Agency Information Collection Activities; Proposed Collection; Comments Requested: Police Check...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-07

... other forms of information technology, e.g., permitting electronic submission of responses. Summary of... qualification requirements to be considered for access to ATF information, information technology systems, and..., citizenship, drug use, financial history, firearms/explosives licensing, criminal history, and conduct...

Technology Deployment Annual Report 2014 December

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arterburn, George K.

This report is a summary of key Technology Deployment activities and achievements for 2014, including intellectual property, granted copyrights, royalties, license agreements, CRADAs, WFOs and Technology-Based Economic Development. Idaho National Laboratory (INL) is a Department of Energy (DOE) multi-program national laboratory that conducts research and development in all DOE mission areas. Like all other federal laboratories, INL has a statutory, technology transfer mission to make its capabilities and technologies available to all federal agencies, to state and local governments, and to universities and industry. To fulfill this mission, INL encourages its scientific, engineering, and technical staff to disclose new inventionsmore » and creations to ensure the resulting intellectual property is captured, protected, and made available to others who might benefit from it. As part of the mission, intellectual property is licensed to industrial partners for commercialization, creating jobs and delivering the benefits of federally funded technology to consumers. In other cases, unique capabilities are made available to other federal agencies or to regional small businesses to solve specific technical challenges. INL employees also work cooperatively with researchers and technical staff from the university and industrial sectors to further develop emerging technologies. In our multinational global economy, INL is contributing to the development of the next generation of engineers and scientists by licensing software to educational instiutitons throughout the world. This report is a catalog of selected INL technology transfer and commercialization transactions during this past year. The size and diversity of INL technical resources, coupled with the large number of relationships with other organizations, virtually ensures that a report of this nature will fail to capture all interactions. Recognizing this limitation, this report focuses on transactions that are specifically authorized by technology transfer legislation (and corresponding contractual provisions) or involve the transfer of legal rights to technology to other parties. This report was compiled from primary records, which were readily available to the INL’s Office of Technology Deployment. However, the accomplishments cataloged in the report reflect the achievements and creativity of the researchers, technicians, support staff, and operators of the INL workforce.« less

AVC/H.264 patent portfolio license

NASA Astrophysics Data System (ADS)

Horn, Lawrence A.

2004-11-01

MPEG LA, LLC recently announced terms of a joint patent license for the AVC (a/k/a H.264) Standard (ISO/IEC IS 14496-10: Information technology -- Coding of audio-visual objects -- Part 10: Advanced Video Coding | ITU-T Rec. H.264: Series H: Audiovisual and Multimedia Systems: Infrastructure of audiovisual services -- Coding of moving video: Advanced video coding for generic audiovisual services). Like MPEG LA"s other licenses, the AVC Patent Portfolio License is offered for the convenience of the marketplace as an alternative enabling users to access essential intellectual property owned by many patent holders under a single license rather than negotiating licenses with each of them individually. The AVC Patent Portfolio License includes essential patents owned by Columbia Innovation Enterprises; Electronics and Telecommunications Research Institute (ETRI); France Télécom, société anonyme; Fujitsu Limited; Koninklijke Philips Electronics N.V.; Matsushita Electric Industrial Co., Ltd.; Microsoft Corporation; Mitsubishi Electric Corporation; Robert Bosch GmbH; Samsung Electronics Co., Ltd.; Sharp Kabushiki Kaisha; Sony Corporation; Toshiba Corporation; and Victor Company of Japan, Limited. MPEG LA"s objective is to provide worldwide access to as much AVC essential intellectual property as possible for the benefit of AVC users. Therefore, any party that believes it has essential patents is welcome to submit them for evaluation of their essentiality and inclusion in the License if found essential.

Lessons learned during the development and transfer of technology related to a new Hib conjugate vaccine to emerging vaccine manufacturers.

PubMed

Hamidi, A; Boog, C; Jadhav, S; Kreeftenberg, H

2014-07-16

The incidence of Haemophilus Influenzae type b (Hib) disease in developed countries has decreased since the introduction of Hib conjugate vaccines in their National Immunization Programs (NIP). In countries where Hib vaccination is not applied routinely, due to limited availability and high cost of the vaccines, invasive Hib disease is still a cause of mortality. Through the development of a production process for a Hib conjugate vaccine and related quality control tests and the transfer of this technology to emerging vaccine manufacturers in developing countries, a substantial contribution was made to the availability and affordability of Hib conjugate vaccines in these countries. Technology transfer is considered to be one of the fastest ways to get access to the technology needed for the production of vaccines. The first Hib conjugate vaccine based on the transferred technology was licensed in 2007, since then more Hib vaccines based on this technology were licensed. This paper describes the successful development and transfer of Hib conjugate vaccine technology to vaccine manufacturers in India, China and Indonesia. By describing the lessons learned in this process, it is hoped that other technology transfer projects can benefit from the knowledge and experience gained. Copyright © 2014 Elsevier Ltd. All rights reserved.

Analyze Technology Options | Climate Neutral Research Campuses | NREL

Science.gov Websites

Analyze Technology Options Analyze Technology Options An effective climate action plan follows a options would fit into a campus climate action plan and provides examples of how others have used these technologies. Links to definitions, technology basics, and references are also provided. Use the Climate Action

Training Centers for Onsite Wastewater Treatment

EPA Pesticide Factsheets

Onsite wastewater training centers offer classes, demonstration projects and research facilities for onsite industry professionals. Classes include wastewater management, new technologies and pre-licensing.

76 FR 31311 - Notice of Submission for OMB Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-31

..., electronic, mechanical, or other technological collection techniques or other forms of information technology... federal and other property. Under the Randolph-Sheppard Program, state licensing agencies recruit, train..., snack bars, vending machines, etc.) located on federal and other properties. In statute at 20 U.S.C...

78 FR 24758 - Government-Owned Inventions; Availability for Licensing

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-26

...-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B... . Antimalarial Inhibitors That Target the Plasmodial Surface Anion Channel (PSAC) Protein and Development of the PSAC Protein as Vaccine Targets Description of Technology: There are two related technologies, the...

DEMONSTRATION BULLETIN: AOSTRA-SOILTECH ANAEROBIC THERMAL PROCESSOR: WIDE BEACH DEVELOPMENT SITE

EPA Science Inventory

The anaerobic thermal processor (ATP) was developed by UMATAC Industrial Processes under the sponsorship of the Alberta Oil Sands Technology and Research Authority (AOSTRA) and is licensed by SoilTech ATP Systems, Inc., a U.S. corporation. The ATP technology involves a physi...

10 CFR 1.42 - Office of Nuclear Material Safety and Safeguards.

Code of Federal Regulations, 2014 CFR

2014-01-01

... responsible for regulation and licensing of recycling technologies intended to reduce the amount of waste to... an appropriate regulatory framework, in recycling during development, demonstration, and deployment of new advanced recycling technologies that recycle nuclear fuel in a manner which does not produce...

10 CFR 1.42 - Office of Nuclear Material Safety and Safeguards.

Code of Federal Regulations, 2013 CFR

2013-01-01

... responsible for regulation and licensing of recycling technologies intended to reduce the amount of waste to... an appropriate regulatory framework, in recycling during development, demonstration, and deployment of new advanced recycling technologies that recycle nuclear fuel in a manner which does not produce...

10 CFR 1.42 - Office of Nuclear Material Safety and Safeguards.

Code of Federal Regulations, 2011 CFR

2011-01-01

... responsible for regulation and licensing of recycling technologies intended to reduce the amount of waste to... an appropriate regulatory framework, in recycling during development, demonstration, and deployment of new advanced recycling technologies that recycle nuclear fuel in a manner which does not produce...

10 CFR 1.42 - Office of Nuclear Material Safety and Safeguards.

Code of Federal Regulations, 2010 CFR

2010-01-01

... responsible for regulation and licensing of recycling technologies intended to reduce the amount of waste to... an appropriate regulatory framework, in recycling during development, demonstration, and deployment of new advanced recycling technologies that recycle nuclear fuel in a manner which does not produce...

10 CFR 1.42 - Office of Nuclear Material Safety and Safeguards.

Code of Federal Regulations, 2012 CFR

2012-01-01

... responsible for regulation and licensing of recycling technologies intended to reduce the amount of waste to... an appropriate regulatory framework, in recycling during development, demonstration, and deployment of new advanced recycling technologies that recycle nuclear fuel in a manner which does not produce...

Technology Commercialization Effects on the Conduct of Research in Higher Education

PubMed Central

Powers, Joshua B.; Campbell, Eric G.

2012-01-01

The objective of this study was to investigate the effects of technology commercialization on researcher practice and productivity at U.S. universities. Using data drawn from licensing contract documents and databases of university-industry linkages and faculty research output, the study findings suggest that the common practice of licensing technologies exclusively to singular firms may have a dampening effect on faculty inventor propensity to conduct published research and to collaborate with others on research. Furthermore, faculty who are more actively engaged in patenting may be less likely to collaborate with outsiders on research while faculty at public universities may experience particularly strong norms to engage in commercialization vis-à-vis traditional routes to research dissemination. These circumstances appear to be hindering innovation via the traditional mechanisms (research publication and collaboration), questioning the success of policymaking to date for the purpose of speeding the movement of research from the lab bench to society. PMID:22427717

Practicing for space underwater: inventing neutral buoyancy training, 1963-1968.

PubMed

Neufeld, Michael J; Charles, John B

2015-01-01

Neutral buoyancy's value was far from obvious when human spaceflight began in 1961. Starting in 1964, Environmental Research Associates, a tiny company in the suburbs of Baltimore, developed the key innovations in an obscure research project funded by NASA's Langley Research Center. The new Houston center dismissed it until a mid-1966 EVA crisis, after which it rapidly took over. In parallel, NASA Marshall Space Flight Center developed many of the same techniques, as did many large aerospace corporations, yet the long-run technological impact of corporate activity was near zero. Because ERA and Marshall's pioneering activities led to the two long-running NASA training centers at Houston and Huntsville, those two organizations deserve primary credit for the construction of the neutral buoyancy technological system. Published by Elsevier Ltd.

Locating Leadership: The Blind Spot in Alberta's Technology Policy Discourse

ERIC Educational Resources Information Center

Brooks, Charmaine

2011-01-01

Over the last 20 years, technology and education policy discourse in Alberta, Canada has been philosophically polarized and dominated by value-neutral ways of thinking about technology (Brooks, 2011). While technology policy implementation has significant ramifications for schools and systems, for much of this time, system leaders, specifically…

Disruptive Technologies in Workmanship: pH-neutral Flux, CDM ESD Events, HDI PCBs

NASA Technical Reports Server (NTRS)

Plante, Jeannette F.

2010-01-01

This slide presentation describes what it calls "disruptive technologies", i.e., "Low-end disruption" occurs when the rate at which products improve exceeds the rate at which customers can adopt the new performance. Therefore, at some point the performance of the product overshoots the needs of certain customer segments. At this point, a disruptive technology may enter the market and provide a product which has lower performance than the incumbent but which exceeds the requirements of certain segments, thereby gaining a foothold in the market. This concept is viewed in impacting incumbent technologies Rosin Flux, with a pH-neutral water soluble Flux; electrostatic discharge models being disrupted by the charge device model (CDM) concept; and High Density Interconnect Printed Circuit Boards (HDI PCB).

15 CFR 743.1 - Wassenaar Arrangement.

Code of Federal Regulations, 2010 CFR

2010-01-01

... exports of certain commodities, software and technology controlled under the Wassenaar Arrangement. Such...). Note that exports of technology and source code under License Exception TSR to foreign nationals... 2B001.b.2) of the Commerce Control List (CCL). Reports for 2E001, are for “technology” according to the...

Work with Us | Advanced Manufacturing Research | NREL

Science.gov Websites

advanced manufacturing R&D project through analysis and our world-class facilities. Contact Us Headshot of a man Matthew Ringer Laboratory Program Manager, Advanced Manufacturing Email | 303-275-4469 facilities for your advanced manufacturing R&D projects. License Our Technologies See our technologies

78 FR 7819 - Request to Amend a License to Import

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-04

... 10 CFR 110.70 (b) ``Public Notice of Receipt of an Application,'' please take notice that the Nuclear... Country; from application no.; docket No. Eastern Technologies, Inc.; Class A radioactive Up to a maximum... Mexico. Following nuclear power plant processing at operations and Eastern maintenance). The Technologies...

Cancer Immunotherapy Using Virus-like Particles | NCI Technology Transfer Center | TTC

Cancer.gov

A considerable effort has been devoted to identifying and targeting specific extracellular cancer markers using antibody based therapies. However, diminished access to new cancer cell surface markers has limited the development of corresponding antibodies. NCI Technology Transfer Center is seeking to license cancer immunotherapy using virus-like particles.

Vaccine for BK Polyomavirus-associated Infections in Transplant Recipients | NCI Technology Transfer Center | TTC

Cancer.gov

NCI researches identified a BK polyomavirus (BKV) virulent strain that causes chronic urinary tract infections, and the development of vaccine and therapeutic methods that would block BKV pathogenesis. The NCI Laboratory of Cellular Oncology, seek parties to license or co-develop this technology.

Spinoff from Wind Tunnel Technology

NASA Technical Reports Server (NTRS)

1985-01-01

Douglas Juanarena, a former NASA Langley instrument design engineer, found a solution to the problem of long, repetitive tunnel runs needed to measure airflow pressures. Electronically scanned pressure (ESP) replaced mechanical systems with electronic sensors. Juanarena licensed the NASA-patented technology and now manufactures ESP modules for research centers, aerospace companies, etc.

EARTH TECH INC.'S ENHANCED IN-SITU BIOREMEDIATION PROCESS; INNOVATIVE TECHNOLOGY EVALUATION REPORT

EPA Science Inventory

The USEPA conducted an evaluation of the Enhanced In-situ Bioremediation process, a biostimulation technology developed by the USDOE at the Westinghouse Savannah River Plant site in Aiken, SC. DOE has licensed the process to Earth Tech, Inc. The evaluation described in this bulle...

Technology, Privacy, and Electronic Freedom of Speech.

ERIC Educational Resources Information Center

McDonald, Frances M.

1986-01-01

Explores five issues related to technology's impact on privacy and access to information--regulation and licensing of the press, electronic surveillance, invasion of privacy, copyright, and policy-making and regulation. The importance of First Amendment rights and civil liberties in forming a coherent national information policy is stressed.…

The effects of business practices, licensing, and intellectual property on development and dissemination of the polymerase chain reaction: case study

PubMed Central

Fore, Joe; Wiechers, Ilse R; Cook-Deegan, Robert

2006-01-01

Introduction Polymerase chain reaction (PCR) was a seminal genomic technology discovered, developed, and patented in an industry setting. Since the first of its core patents expired in March, 2005, we are in a position to view the entire lifespan of the patent, examining how the intellectual property rights have impacted its use in the biomedical community. Given its essential role in the world of molecular biology and its commercial success, the technology can serve as a case study for evaluating the effects of patenting biological research tools on biomedical research. Case description Following its discovery, the technique was subjected to two years of in-house development, during which issues of inventorship and publishing/patenting strategies caused friction between members of the development team. Some have feared that this delay impeded subsequent research and may have been due to trade secrecy or the desire for obtaining lucrative intellectual property rights. However, our analysis of the history indicates that the main reasons for the delay were benign and were primarily due to difficulties in perfecting the PCR technique. Following this initial development period, the technology was made widely available, but was subject to strict licensing terms and patent protection, leading to an extensive litigation history. Discussion and evaluation PCR has earned approximately $2 billion in royalties for the various rights-holders while also becoming an essential research tool. However, using citation trend analysis, we are able to see that PCR's patented status did not preclude it from being adopted in a similar manner as other non-patented genomic research tools (specifically, pBR322 cloning vector and Maxam-Gilbert sequencing). Conclusion Despite the heavy patent protection and rigid licensing schemes, PCR seems to have disseminated so widely because of the practices of the corporate entities which have controlled these patents, namely through the use of business partnerships and broad corporate licensing, adaptive licensing strategies, and a "rational forbearance" from suing researchers for patent infringement. While far from definitive, our analysis seems to suggest that, at least in the case of PCR, patenting of genomic research tools need not impede their dissemination, if the technology is made available through appropriate business practices. PMID:16817955

Biosecurity in the age of Big Data: a conversation with the FBI.

PubMed

You, Edward; Kozminski, Keith G

2015-11-05

New scientific frontiers and emerging technologies within the life sciences pose many global challenges to society. Big Data is a premier example, especially with respect to individual, national, and international security. Here a Special Agent of the Federal Bureau of Investigation discusses the security implications of Big Data and the need for security in the life sciences. © 2015 Kozminski. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Troika partnership model for licensing NASA-LaRC technologies

NASA Technical Reports Server (NTRS)

Maclin, Arlene P.

1995-01-01

The Technology Applications (TAG) Group at NASA Langley Research Center has currently more than 100 technologies that are ripe for commercialization. These technologies are categorized by various sectors including: Energy and the Environment; Materials and Structures; Manufacturing; Information and Communications; Transportation, and Medical/Sensor/ Instrumentation. A requirement that TAG has placed on all technologies ready for licensing is that there will be some university involvement in the technology transfer or knowledge transfer process. This model involves the troika of government (LaRC), industry and university. A number of variations on the Troika Partnership Model (TPM) were developed as a part of this ASEE Fellowship. Furthermore, five technologies were identified - three of which industrial interests have been matched: LaRC-SI, a thermoplastic that can be used as a coating; Variable Geometry Truss Manipulator Arm that can be used for nuclear waste clean -up and as scaffolding; and ADAPT (Approach to Data Management, Archive Protection, and Transmission) is a technology that could be used for a variety of multi-tasking operations over the Internet. The aim of this work was to initiate a Space Act Agreement (SAA) for at least one of these technologies using one of the options of the TPM. A preliminary partnership agreement using the SAA is currently being negotiated with NASA-LaRC, VPI and Virginia Power for the LaRC-SI thermoplastic that will be used as a coating.

47 CFR 64.601 - Definitions and provisions of general applicability.

Code of Federal Regulations, 2014 CFR

2014-10-01

... a text telephone (TTY) and the public switched telephone network. (18) IP Relay access technology... used to make and receive an Internet-based TRS call. (20) Neutral Video Communication Service Platform... by the Neutral Video Communication Service Platform include the provision of a video link, user...

47 CFR 64.601 - Definitions and provisions of general applicability.

Code of Federal Regulations, 2013 CFR

2013-10-01

... a text telephone (TTY) and the public switched telephone network. (18) IP Relay access technology... used to make and receive an Internet-based TRS call. (20) Neutral Video Communication Service Platform... by the Neutral Video Communication Service Platform include the provision of a video link, user...

Technology Access from the FS-X Radar Program. Lessons for Technology Transfer and U.S. Acquisition Policy

DTIC Science & Technology

1994-01-01

and subsequent bilateral negotiations entitle the United States to the "free and automatic flowback " of all Japanese "derived technology," defined as...White Paper, US. Departments of Commerce, Defense, and Air Force, May 1991. 3Pree and automatic flowback of derived technology has precedent in licensed...By receiving indigenous Japanese FS-X technology, US. firms may be obligating themselves to provide free flowback to Japan of any modifications they

Agencies Should Assess Vulnerabilities and Improve Guidance for Protecting Export-Controlled Information at Companies

DTIC Science & Technology

2006-12-01

Supplement DOD Department of Defense DOL Department of Labor DTSA Defense Technology Security Administration EAR Export Administration Regulations...and outreach to companies on the export regulations. DOD: The Defense Technology Security Administration ( DTSA ) represents DOD on export control...and technologies, which DOD oversees. DTSA serves an advisory role in State’s and Commerce’s export license review processes and offers technical

Improved Ribosome-Footprint and mRNA Measurements Provide Insights into Dynamics and Regulation of Yeast Translation

DTIC Science & Technology

2016-02-11

the White- head Genome Technology Core for sequencing . This work was supported by the UCSF Program for Breakthrough Biomedical Research (funded in...landscape of the yeast genome defined by RNA sequencing . Science 320, 1344–1349. Nedialkova, D.D., and Leidel, S.A. (2015). Optimization of Codon Translation... the CC BY license (http://creativecommons.org/licenses/by/4.0/). SUMMARY Ribosome-footprint profiling provides genome -wide snapshots of translation

Technology evaluation: adalimumab, Abbott laboratories.

PubMed

Lorenz, Hanns M

2002-04-01

Adalimumab (D2E7), a human monoclonal antibody that binds to and neutralizes TNFa, is being developed by Abbott (formerly Knoll), under license from Cambridge Antibody Technology (CAT), for the potential treatment of inflammatory disorders such as rheumatoid arthritis (RA) and Crohn's disease. It is also being investigated for the potential treatment of coronary heart disease. Phase II studies for Crohn's disease and phase III for RA were ongoing throughout 2001. Limited data are only available for RA. In January 2002, it was reported that phase III trials of adalimumab for RA had been completed, but details have not been published in the primary literature so far. At this time CAT and Abbott expected to file for US approval in the second quarter of 2002 with a launch date anticipated for 2003. Phase III data are expected to be presented at the European League Against Rheumatism meeting in June 2002. In November 2000, Lehman Brothers predicted a US launch in June 2002 with peak US sales of $600 million in 2007 and a launch in non-US markets in 2003 with peak sales in these markets of $300 million in 2008. In December 2000, Merrill Lynch predicted regulatory clearance in the second half of 2003. The probability of adalimumab reaching the market is estimated to be 70%. In December 2000, Merrill Lynch predicted a 2003 launch, with estimated sales of pounds sterling 3.65 million in that year rising to pounds sterling 30.14 million in 2010. In March 2001, ABN AMRO predicted sales of $73 million in 2003 rising to $392 million in 2007.

Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation

PubMed Central

Goodwin, Eileen; Gilman, Morgan S. A.; Wrapp, Daniel; Chen, Man; Ngwuta, Joan O.; Moin, Syed M.; Bai, Patricia; Sivasubramanian, Arvind; Connor, Ruth I.; Wright, Peter F.; Graham, Barney S.; McLellan, Jason S.; Walker, Laura M.

2018-01-01

SUMMARY Respiratory syncytial virus (RSV) is a leading cause of infant mortality, and there are currently no licensed vaccines to protect this vulnerable population. A comprehensive understanding of infant antibody responses to natural RSV infection would facilitate vaccine development. Here, we isolated over 450 RSV fusion glycoprotein (F)-specific antibodies from seven RSV-infected infants and found that half of the antibodies recognized only two antigenic sites. Antibodies targeting both sites showed convergent sequence features, and structural studies revealed the molecular basis for their recognition of RSV F. A subset of antibodies targeting one of these sites displayed potent neutralizing activity despite lacking somatic mutations, and similar antibodies were detected in RSV-naïve B cell repertoires, suggesting that expansion of these B cells in infants may be possible with suitably designed vaccine antigens. Collectively, our results provide fundamental insights into infant antibody responses and a framework for the rational design of age-specific RSV vaccines. PMID:29396163

Optimal Use of Vaccines for Control of Influenza A Virus in Swine

PubMed Central

Sandbulte, Matthew R.; Spickler, Anna R.; Zaabel, Pamela K.; Roth, James A.

2015-01-01

Influenza A virus in swine (IAV-S) is one of the most important infectious disease agents of swine in North America. In addition to the economic burden of IAV-S to the swine industry, the zoonotic potential of IAV-S sometimes leads to serious public health concerns. Adjuvanted, inactivated vaccines have been licensed in the United States for over 20 years, and there is also widespread usage of autogenous/custom IAV-S vaccines. Vaccination induces neutralizing antibodies and protection against infection with very similar strains. However, IAV-S strains are so diverse and prone to mutation that these vaccines often have disappointing efficacy in the field. This scientific review was developed to help veterinarians and others to identify the best available IAV-S vaccine for a particular infected herd. We describe key principles of IAV-S structure and replication, protective immunity, currently available vaccines, and vaccine technologies that show promise for the future. We discuss strategies to optimize the use of available IAV-S vaccines, based on information gathered from modern diagnostics and surveillance programs. Improvements in IAV-S immunization strategies, in both the short term and long term, will benefit swine health and productivity and potentially reduce risks to public health. PMID:26344946

Evaluation of the potential for operating carbon neutral WWTPs in China.

PubMed

Hao, Xiaodi; Liu, Ranbin; Huang, Xin

2015-12-15

Carbon neutrality is starting to become a hot topic for wastewater treatment plants (WWTPs) all over the world, and carbon neutral operations have emerged in some WWTPs. Although China is still struggling to control its water pollution, carbon neutrality will definitely become a top priority for WWTPs in the near future. In this review, the potential for operating carbon neutral WWTPs in China is technically evaluated. Based on the A(2)/O process of a typical municipal WWTP, an evaluation model is first configured, which couples the COD/nutrient removals (mass balance) with the energy consumption/recovery (energy balance). This model is then applied to evaluate the potential of the organic (COD) energy with regards to carbon neutrality. The model's calculations reveal that anaerobic digestion of excess sludge can only provide some 50% of the total amount of energy consumption. Water source heat pumps (WSHP) can effectively convert the thermal energy contained in wastewater to heat WWTPs and neighbourhood buildings, which can supply a net electrical equivalency of 0.26 kWh when 1 m(3) of the effluent is cooled down by 1 °C. Photovoltaic (PV) technology can generate a limited amount of electricity, barely 10% of the total energy consumption. Moreover, the complexity of installing solar panels on top of tanks makes PV technology almost not worth the effort. Overall, therefore, organic and thermal energy sources can effectively supply enough electrical equivalency for China to approach to its target with regards to carbon neutral operations. Copyright © 2015 Elsevier Ltd. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aytug, Tolga

Samsung Electronics has exclusively licensed optically clear superhydrophobic film technology from the Department of Energy’s Oak Ridge National Laboratory to improve the performance of glass displays on smartphones, tablets and other electronic devices.

47 CFR 0.131 - Functions of the Bureau.

Code of Federal Regulations, 2011 CFR

2011-10-01

... economic, technological, legislative, regulatory and judicial information and developments. Such matters... growth by promoting efficiency and innovation in the allocation, licensing and use of the electromagnetic...

15 CFR 255.2 - Qualifications.

Code of Federal Regulations, 2010 CFR

2010-01-01

... STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE FELLOWSHIPS AND RESEARCH ASSOCIATES FELLOWSHIPS IN... than the United States; (b) In possession of a certificate of medical examination issued by a licensed...

Development of broad-spectrum human monoclonal antibodies for rabies post-exposure prophylaxis.

PubMed

De Benedictis, Paola; Minola, Andrea; Rota Nodari, Elena; Aiello, Roberta; Zecchin, Barbara; Salomoni, Angela; Foglierini, Mathilde; Agatic, Gloria; Vanzetta, Fabrizia; Lavenir, Rachel; Lepelletier, Anthony; Bentley, Emma; Weiss, Robin; Cattoli, Giovanni; Capua, Ilaria; Sallusto, Federica; Wright, Edward; Lanzavecchia, Antonio; Bourhy, Hervé; Corti, Davide

2016-04-01

Currently available rabies post-exposure prophylaxis (PEP) for use in humans includes equine or human rabies immunoglobulins (RIG). The replacement of RIG with an equally or more potent and safer product is strongly encouraged due to the high costs and limited availability of existing RIG. In this study, we identified two broadly neutralizing human monoclonal antibodies that represent a valid and affordable alternative to RIG in rabies PEP. Memory B cells from four selected vaccinated donors were immortalized and monoclonal antibodies were tested for neutralizing activity and epitope specificity. Two antibodies, identified as RVC20 and RVC58 (binding to antigenic site I and III, respectively), were selected for their potency and broad-spectrum reactivity. In vitro, RVC20 and RVC58 were able to neutralize all 35 rabies virus (RABV) and 25 non-RABV lyssaviruses. They showed higher potency and breath compared to antibodies under clinical development (namely CR57, CR4098, and RAB1) and commercially available human RIG. In vivo, the RVC20-RVC58 cocktail protected Syrian hamsters from a lethal RABV challenge and did not affect the endogenous hamster post-vaccination antibody response. © 2016 Humabs BioMed SA Published under the terms of the CC BY 4.0 license.

Microgravity

NASA Image and Video Library

2004-04-15

Ecomaster, an affiliate of BioServe Space Technologies, this PentaPure technology has been used to purify water for our nation's Space Shuttle missions since 1981. WTC-Ecomaster of Mirneapolis, Minnesota manufactures water purification systems under the brand name PentaPure (TM). BioServe researcher Dr. George Marchin, of Kansas State University, first demonstrated the superiority of this technology and licensed it to WTC. Marchin continues to perform microgravity research in the development of new technologies for the benefit of life on Earth.

Water Purification Product

NASA Technical Reports Server (NTRS)

2004-01-01

Ecomaster, an affiliate of BioServe Space Technologies, this PentaPure technology has been used to purify water for our nation's Space Shuttle missions since 1981. WTC-Ecomaster of Mirneapolis, Minnesota manufactures water purification systems under the brand name PentaPure (TM). BioServe researcher Dr. George Marchin, of Kansas State University, first demonstrated the superiority of this technology and licensed it to WTC. Marchin continues to perform microgravity research in the development of new technologies for the benefit of life on Earth.

License Agreement Moves Promising Technology Into the Marketplace

Science.gov Websites

generated every day by sewage treatment plants. The pretreatment process was developed at the U.S commercialize the technology to Peak Treatment Systems, Inc. of Golden, Colo. Conventional disposal methods completely broken down. Peak Treatment Systems is using the equipment at a pilot-scale high solids anaerobic

42 CFR Appendix F to Part 75 - Standards for Licensing Radiographers, Nuclear Medicine Technologists, and Radiation Therapy...

Code of Federal Regulations, 2010 CFR

2010-10-01

... THE ACCREDITATION OF EDUCATIONAL PROGRAMS FOR AND THE CREDENTIALING OF RADIOLOGIC PERSONNEL Pt. 75... radiography, nuclear medicine technology, or radiation therapy technology. 2. Special eligibility to take the... excess of, those of a graduate of an accredited educational program. C. Examination A criterion...

Development of a Two-Year Associate Arts Degree in Environmental Health Technology.

ERIC Educational Resources Information Center

Campbell, Charles R.

The field of Environmental Health Technology (EHT) encompasses both the equipment and the trained expertise required to utilize land, water, energy, and minerals in the service of human health and welfare. EHT technicians work in disease control, licensing bureaus, hospitals, nursing homes, hazardous waste agencies, and other health agencies. In…

Cabin Pressure Monitors Notify Pilots to Save Lives

NASA Technical Reports Server (NTRS)

2015-01-01

In 2013, San Diego-based Aviation Technology Inc. obtained an exclusive license for the technology behind the cabin pressure monitor invented at Kennedy Space Center and built its own version of the product. The Alt Alert is designed to save lives by alerting aircraft pilots and crews when cabin pressure becomes dangerously low.

75 FR 52932 - Notice of Intent To Grant an Exclusive License; Doar, Pekuin, Sall Limited Liability Company

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-30

... Government- Owned invention as described in U.S. Patent No. 6,404,407 entitled ``Ridge laser with oxidized... National Security Agency Technology Transfer Program, 9800 Savage Road, Suite 6541, Fort George G. Meade, MD 20755-6541. FOR FURTHER INFORMATION CONTACT: Marian T. Roche, Director, Technology Transfer...

37 CFR 201.28 - Statements of Account for digital audio recording devices or media.

Code of Federal Regulations, 2010 CFR

2010-07-01

... following information for each unique combination of product category, technology, series or model number... quarterly period covered by the statement. (9) Technology of a device or medium is a digital audio recording... Congress. Forms and other information may be requested from the Licensing Division by facsimile...

Technology Commercialization Effects on the Conduct of Research in Higher Education

ERIC Educational Resources Information Center

Powers, Joshua B.; Campbell, Eric G.

2011-01-01

The objective of this study was to investigate the effects of technology commercialization on researcher practice and productivity at U.S. universities. Using data drawn from licensing contract documents and databases of university-industry linkages and faculty research output, the study findings suggest that the common practice of licensing…

77 FR 13684 - Commercial Driver's License Standards: Application for Exemption; Daimler Trucks North America...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-07

... requirements and to promote the development of technology advancements in vehicle safety systems and emissions...'' environments in the U.S. market, and verify results. Daimler believes the requirements for a German CDL are... environmental regulatory requirements and to promote the development of technology advancements in vehicle...

78 FR 21314 - Medicare and State Health Care Programs: Fraud and Abuse; Electronic Health Records Safe Harbor...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-10

... health records software or information technology and training services. The final rule for this safe... health records software or information technology and training services. In the same issue of the Federal..., licenses, and intellectual property related to electronic health records software; connectivity services...

A Head Start to a Healthy Heart

NASA Technical Reports Server (NTRS)

2002-01-01

Cambridge Heart, Inc., has licensed the only U.S. Food and Drug Administration-cleared tool to identify those at risk for sudden cardiac death (SCD). The Microvolt T-Wave Alternans Test(TM) was invented by Dr. Richard J. Cohen, a professor at the Harvard-Massachusetts Institute of Technology (MIT) Division of Health Sciences and Technology, with developmental support and funding from NASA's Johnson Space Center and the National Space Biomedical Research Institute (NSBRI) in Houston, Texas. In 1993, MIT licensed the technology to Cambridge Heart, Inc., a start-up company that Dr. Cohen helped to establish. Cambridge Heart's non-invasive technology measures T-wave alternans, a change from one heartbeat to the next that is too minute to be detected by a standard electrocardiogram. Cardiac patients with such a change in heartbeat regulation are faced with a much greater risk of ventricular arrhythmia and SCD than those without it. The company's ability to measure electrical alternans on a microvolt level has been clinically proven to be just as accurate as - and in some studies, more accurate than - more costly and somewhat risky, invasive procedures, such as electrophysiological testing.

ARCHITECTURE AS PEDAGOGY: INTERDISCIPLINARY DESIGN AND CREATION OF A CARBON NEUTRAL IDAHO ENVIRONMENTAL LEARNING CENTER AT THE UNIVERSITY OF IDAHO MCCALL FIELD CAMPUS

EPA Science Inventory

Output 1. (short-term) Design a carbon neutral field campus with the following design components: structural systems, building envelope, environmental systems, site construction, building materials, information technology, spatial systems and integration ...