IL-4/IL-13 Signaling Inhibits the Potential of Early Thymic Progenitors To Commit to the T Cell Lineage.

PubMed

Barik, Subhasis; Miller, Mindy M; Cattin-Roy, Alexis N; Ukah, Tobechukwu K; Chen, Weirong; Zaghouani, Habib

2017-10-15

Early thymic progenitors (ETPs) are endowed with diverse potencies and can give rise to myeloid and lymphoid lineage progenitors. How the thymic environment guides ETP commitment and maturation toward a specific lineage remains obscure. We have previously shown that ETPs expressing the heteroreceptor (HR) comprising IL-4Rα and IL-13Rα1 give rise to myeloid cells but not T cells. In this article, we show that signaling through the HR inhibits ETP maturation to the T cell lineage but enacts commitment toward the myeloid cells. Indeed, HR + ETPs, but not HR - ETPs, exhibit activated STAT6 transcription factor, which parallels with downregulation of Notch1, a critical factor for T cell development. Meanwhile, the myeloid-specific transcription factor C/EBPα, usually under the control of Notch1, is upregulated. Furthermore, in vivo inhibition of STAT6 phosphorylation restores Notch1 expression in HR + ETPs, which regain T lineage potential. In addition, upon stimulation with IL-4 or IL-13, HR - ETPs expressing virally transduced HR also exhibit STAT6 phosphorylation and downregulation of Notch1, leading to inhibition of lymphoid, but not myeloid, lineage potential. These observations indicate that environmental cytokines play a role in conditioning ETP lineage choice, which would impact T cell development. Copyright © 2017 by The American Association of Immunologists, Inc.

Silencing of GATA3 defines a novel stem cell-like subgroup of ETP-ALL.

PubMed

Fransecky, L; Neumann, M; Heesch, S; Schlee, C; Ortiz-Tanchez, J; Heller, S; Mossner, M; Schwartz, S; Mochmann, L H; Isaakidis, K; Bastian, L; Kees, U R; Herold, T; Spiekermann, K; Gökbuget, N; Baldus, C D

2016-09-22

GATA3 is pivotal for the development of T lymphocytes. While its effects in later stages of T cell differentiation are well recognized, the role of GATA3 in the generation of early T cell precursors (ETP) has only recently been explored. As aberrant GATA3 mRNA expression has been linked to cancerogenesis, we investigated the role of GATA3 in early T cell precursor acute lymphoblastic leukemia (ETP-ALL). We analyzed GATA3 mRNA expression by RT-PCR (n = 182) in adult patients with T-ALL. Of these, we identified 70 of 182 patients with ETP-ALL by immunophenotyping. DNA methylation was assessed genome wide (Illumina Infinium® HumanMethylation450 BeadChip platform) in 12 patients and GATA3-specifically by pyrosequencing in 70 patients with ETP-ALL. The mutational landscape of ETP-ALL with respect to GATA3 expression was investigated in 18 patients and validated by Sanger sequencing in 65 patients with ETP-ALL. Gene expression profiles (Affymetrix Human genome U133 Plus 2.0) of an independent cohort of adult T-ALL (n = 83) were used to identify ETP-ALL and investigate GATA3 low and GATA3 high expressing T-ALL patients. In addition, the ETP-ALL cell line PER-117 was investigated for cytotoxicity, apoptosis, GATA3 mRNA expression, DNA methylation, and global gene expression before and after treatment with decitabine. In our cohort of 70 ETP-ALL patients, 33 % (23/70) lacked GATA3 expression and were thus defined as GATA3 low . DNA methylation analysis revealed a high degree of GATA3 CpG island methylation in GATA3 low compared with GATA3 high ETP-ALL patients (mean 46 vs. 21 %, p < 0.0001). Genome-wide expression profiling of GATA3 low ETP-ALL exhibited enrichment of myeloid/lymphoid progenitor (MLP) and granulocyte/monocyte progenitor (GMP) genes, while T cell-specific signatures were downregulated compared to GATA3 high ETP-ALL. Among others, FLT3 expression was upregulated and mutational analyses demonstrated a high rate (79 %) of FLT3 mutations. Hypomethylating agents induced reversal of GATA3 silencing, and gene expression profiling revealed downregulation of hematopoietic stem cell genes and upregulation of T cell differentiation. We propose GATA3 low ETP-ALL as a novel stem cell-like leukemia with implications for the use of myeloid-derived therapies.

77 FR 29419 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing of Proposed Rule Change...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-17

...,000.\\3\\ ETP issuers also pay a graduated Annual Fee based on the number of shares of the ETP that are..., and the ETP therefore trades without an LMM assigned to it. The Exchange operates under the price-time... may be higher for certain ETPs with low volume and low shares outstanding because there are fewer...

The impact of later trading hours for hotels (public houses) on breath alcohol levels of apprehended impaired drivers.

PubMed

Chikritzhs, Tanya; Stockwell, Tim

2007-10-01

To examine the impact of extended trading permits (ETPs) for licensed hotels in Perth, Western Australia on impaired driver breath alcohol levels (BALs) between July 1993 and June 1997. Forty-three hotels obtained ETPs allowing later closing hours and 130 maintained standard closing time (controls). Impaired driver BALs were linked to 'last place of drinking' hotels. Before and after period BALs of drivers who last drank at ETP or non-ETP hotels were compared by time of day of apprehension and sex, controlling for age. Impaired female drivers apprehended between 10.01 p.m. and 12 midnight (before closing time) had significantly lower BALs after drinking at ETP hotels. Male drivers aged 18-25 years and apprehended between 12.01 and 2.00 a.m. after drinking at ETP hotels had significantly higher BALs than drivers who drank at non-ETP hotels. At peak times for alcohol-related offences, late trading is associated with higher BALs among those drinkers most at risk of alcohol-related harm.

Hydroclimatic contrasts over Asian monsoon areas and linkages to tropical Pacific SSTs

PubMed Central

Xu, Hai; Lan, Jianghu; Sheng, Enguo; Liu, Bin; Yu, Keke; Ye, Yuanda; Shi, Zhengguo; Cheng, Peng; Wang, Xulong; Zhou, Xinying; Yeager, Kevin M.

2016-01-01

Knowledge of spatial and temporal hydroclimatic differences is critical in understanding climatic mechanisms. Here we show striking hydroclimatic contrasts between northern and southern parts of the eastern margin of the Tibetan Plateau (ETP), and those between East Asian summer monsoon (EASM) and Indian summer monsoon (ISM) areas during the past ~2,000 years. During the Medieval Period, and the last 100 to 200 years, the southern ETP (S-ETP) area was generally dry (on average), while the northern ETP (N-ETP) area was wet. During the Little Ice Age (LIA), hydroclimate over S-ETP areas was wet, while that over N-ETP area was dry (on average). Such hydroclimatic contrasts can be broadly extended to ISM and EASM areas. We contend that changes in sea surface temperatures (SSTs) of the tropical Pacific Ocean could have played important roles in producing these hydroclimatic contrasts, by forcing the north-south movement of the Intertropical Convergence Zone (ITCZ) and intensification/slowdown of Walker circulation. The results of sensitivity experiments also support such a proposition. PMID:27609356

Ehrlichia chaffeensis and Its Invasin EtpE Block Reactive Oxygen Species Generation by Macrophages in a DNase X-Dependent Manner.

PubMed

Teymournejad, Omid; Lin, Mingqun; Rikihisa, Yasuko

2017-11-21

The obligatory intracellular pathogen Ehrlichia chaffeensis lacks most genes that confer resistance to oxidative stress but can block reactive oxygen species (ROS) generation by host monocytes-macrophages. Bacterial and host molecules responsible for this inhibition have not been identified. To infect host cells, Ehrlichia uses the C terminus of its surface invasin, entry-triggering protein of Ehrlichia (EtpE; EtpE-C), which directly binds the mammalian cell surface receptor glycosylphosphatidylinositol-anchored protein DNase X. We investigated whether EtpE-C binding to DNase X blocks ROS production by mouse bone marrow-derived macrophages (BMDMs). On the basis of a luminol-dependent chemiluminescence assay, E. chaffeensis inhibited phorbol myristate acetate (PMA)-induced ROS generation by BMDMs from wild-type, but not DNase X -/- , mice. EtpE-C is critical for inhibition, as recombinant EtpE-C (rEtpE-C)-coated latex beads, but not recombinant N-terminal EtpE-coated or uncoated beads, inhibited PMA-induced ROS generation by BMDMs from wild-type mice. DNase X is required for this inhibition, as none of these beads inhibited PMA-induced ROS generation by BMDMs from DNase X -/- mice. Previous studies showed that E. chaffeensis does not block ROS generation in neutrophils, a cell type that is a potent ROS generator but is not infected by E. chaffeensis Human and mouse peripheral blood neutrophils did not express DNase X. Our findings point to a unique survival mechanism of ROS-sensitive obligate intramonocytic bacteria that involves invasin EtpE binding to DNase X on the host cell surface. This is the first report of bacterial invasin having such a subversive activity on ROS generation. IMPORTANCE Ehrlichia chaffeensis preferentially infects monocytes-macrophages and causes a life-threatening emerging tick-transmitted infectious disease called human monocytic ehrlichiosis. Ehrlichial infection, and hence the disease, depends on the ability of this bacterium to avoid or overcome powerful microbicidal mechanisms of host monocytes-macrophages, one of which is the generation of ROS. Our findings reveal that an ehrlichial surface invasin, EtpE, not only triggers bacterial entry but also blocks ROS generation by host macrophages through its host cell receptor, DNase X. As ROS sensitivity is an Achilles' heel of this group of pathogens, understanding the mechanism by which E. chaffeensis rapidly blocks ROS generation suggests a new approach for developing effective anti-infective measures. The discovery of a ROS-blocking pathway is also important, as modulation of ROS generation is important in a variety of ailments and biological processes. Copyright © 2017 Teymournejad et al.

50 CFR 216.93 - Tracking and verification program.

Code of Federal Regulations, 2013 CFR

2013-10-01

... canning company in the 50 states, Puerto Rico, or American Samoa receives a domestic or imported shipment... short tons to the fourth decimal, ocean area of capture (ETP, western Pacific, Indian, eastern and...

50 CFR 216.93 - Tracking and verification program.

Code of Federal Regulations, 2014 CFR

2014-10-01

... canning company in the 50 states, Puerto Rico, or American Samoa receives a domestic or imported shipment... short tons to the fourth decimal, ocean area of capture (ETP, western Pacific, Indian, eastern and...

Comparison of the effectiveness and antibiotic cost among ceftriaxone, ertapenem, and levofloxacin in treatment of community-acquired complicated urinary tract infections.

PubMed

Lin, Hsin-An; Yang, Ya-Sung; Wang, Jing-Xun; Lin, Hsin-Chung; Lin, De-Yu; Chiu, Chun-Hsiang; Yeh, Kuo-Ming; Lin, Jung-Chung; Chang, Feng-Yee

2016-04-01

To study characteristics of patients with community-acquired complicated urinary tract infections (cUTIs) and to compare effectiveness and antibiotic cost of treatment with ceftriaxone (CRO), levofloxacin (LVX), and ertapenem (ETP). This retrospective study enrolled patients who had community-acquired cUTIs admitted to Division of Infectious Diseases in a single medical center from January 2011 to March 2013. Effectiveness, antibiotic cost, and clinical characteristics were compared among patients treated with CRO, LVX, and ETP. There were 358 eligible cases, including 139 who received CRO, 128 treated with ETP, and 91 with LVX. The most common pathogen was Escherichia coli. The susceptibilities of these three agents were higher and more superior than first-line antibiotics. Treatment with ETP was associated with a significantly shorter time to defervescence since admission (CRO: 39 hours, ETP: 30 hours, and LVX: 38 h; p = 0.031) and shorter hospitalization stay (CRO: 4 days, ETP: 3 days, and LVX: 4 days; p < 0.001). However, the average antibiotic costs in the CRO group were significantly lower than that in the other two groups [CRO: 62.4 United States dollars (USD), ETP: 185.33 USD, and LVX: 204.85 USD; p < 0.001]. The resistance of cUTIs isolates to first-line antibiotic is high. Using ETP, CRO, and LVX in the treatment of cUTIs for good clinical response should be suggested. Among the three agents, ETP had better susceptibility than CRO and LVX, reached defervescence sooner, and was associated with shorter hospital stays. However, using CRO in cUTIs was less expensive than the other two agents. Copyright © 2015. Published by Elsevier B.V.

The impact of later trading hours for hotels on levels of impaired driver road crashes and driver breath alcohol levels.

PubMed

Chikritzhs, Tanya; Stockwell, Tim

2006-09-01

To examine the impact of later trading hours for licensed hotels in Perth, Western Australia on levels of associated impaired driver road crashes and driver breath alcohol levels (BALs). Police data on the "last place of drinking" for impaired drivers involved in road crashes and their corresponding BALs were examined to identify those associated with Perth hotels between 1 July 1990 and 30 June 1997. During this period, 43 (23%) of the 186 hotels meeting study criteria were granted an Extended Trading Permit for 1 a.m. closing (ETP hotels), while the rest continued to close at midnight (non-ETP hotels). Time-series analyses employing multiple linear regressions were applied to determine whether an association existed between the introduction of extended trading and (i) monthly levels of impaired driver road crashes associated with ETP hotels and (ii) driver BALs associated with ETP hotels. Trends associated with non-ETP hotels were included as controls and possible confounders were considered. After controlling for the trend in crash rates associated with non-ETP hotels and the introduction of mobile police breath testing stations to Perth freeways, a significant increase in monthly crash rates for ETP hotels was found. This relationship was largely accounted for by higher volumes of high-alcohol content beer, wine and spirits purchased by ETP hotels. No relation was found between driver BALs and the introduction of ETPs. Late trading was associated with increased levels of impaired driver road crashes and alcohol consumption, particularly high-risk alcoholic beverages. Greater numbers of patrons and characteristics specific to clientele of hotels which applied for late trading hours (i.e. younger age, greater propensity to drunk-drive, preference for high-risk beverages) were suggested as having contributed to this increase.

Proteins as "dopable" bio-electronic materials

NASA Astrophysics Data System (ADS)

Cahen, David

2013-02-01

Proteins are surprisingly good solid-state electronic conductors. This holds also for proteins without any known biological electron transfer function. How do they do it? To answer this question we measure solid-state electron transport (ETp) across proteins that are "dry" (only tightly bound water, to retain the conformation, still present). We compare results for the electron transfer (ET) protein, Azurin (Az), the proton-pumping membrane protein Bacteriorhodopsin (bR), and for Human and Bovine Serum Albumin (HSA and BSA). Clear differences between these proteins are seen, which preserve their structure in the solid state measurement configuration. Importantly for future bioelectronics, the results are sensitive to protein modification, e.g., removing or disconnecting the retinal in bR and removing or replacing the Cu redox centre in Az. These cofactors can thus be viewed as natural dopants for proteins. Insight in the ETp mechanism comes from temperature-dependent studies. Az shows 40-360K temperature-independent ETp across its 3.5 nm long axis, until its denaturation temperature, indicative of tunneling. Cu removal, replacement (by Zn) or deuteration changes this to thermally activated ETp. This suggests hopping and involvement of the amide backbone in the ETp. The latter, which rhymes with indications from ETp experiments on oligopeptide and simulations of ET in proteins, opens the way for modeling what otherwise is an awfully complex system. Below 200K all proteins and their variants show temperature-independent ETp. We can furthermore make a totally electrically inactive protein, HSA, into an efficient ETp medium by doping it with natural poly-ene. Putting our data in perspective by comparing them to all known protein ETp data in the literature, we conclude that, in general, proteins are well described as dopable molecular wires.

Redox activity distinguishes solid-state electron transport from solution-based electron transfer in a natural and artificial protein: cytochrome C and hemin-doped human serum albumin.

PubMed

Amdursky, Nadav; Ferber, Doron; Pecht, Israel; Sheves, Mordechai; Cahen, David

2013-10-28

Integrating proteins in molecular electronic devices requires control over their solid-state electronic transport behavior. Unlike "traditional" electron transfer (ET) measurements of proteins that involve liquid environments and a redox cycle, no redox cofactor is needed for solid-state electron transport (ETp) across the protein. Here we show the fundamental difference between these two approaches by macroscopic area measurements, which allow measuring ETp temperature dependence down to cryogenic temperatures, via cytochrome C (Cyt C), an ET protein with a heme (Fe-porphyrin) prosthetic group as a redox centre. We compare the ETp to electrochemical ET measurements, and do so also for the protein without the Fe (with metal-free porphyrin) and without porphyrin. As removing the porphyrin irreversibly alters the protein's conformation, we repeat these measurements with human serum albumin (HSA), 'doped' (by non-covalent binding) with a single hemin equivalent, i.e., these natural and artificial proteins share a common prosthetic group. ETp via Cyt C and HSA-hemin are very similar in terms of current magnitude and temperature dependence, which suggests similar ETp mechanisms via these two systems, thermally activated hopping (with ~0.1 eV activation energy) >190 K and tunneling by superexchange <190 K. Also, ET rates to and from the Fe redox centres (Fe(2+) <=> Fe(3+) + e(-)), measured by electrochemistry of HSA-hemin are only 4 times lower than those for Cyt C. However, while removing the Fe redox centre from the porphyrin ring markedly affects the ET rate, it hardly changes the ETp currents through these proteins, while removing the macrocycle (from HSA, which retains its conformation) significantly reduces ETp efficiency. These results show that solid-state ETp across proteins does not require the presence of a redox cofactor, and that while for ET the Fe ion is the main electron mediator, for ETp the porphyrin ring has this function.

Development of Co-Extrusion Technologies for Green Manufacture of Energetics

DTIC Science & Technology

2006-04-01

extrusion, Cc-extruded, ETPE, TPE, Energetic thermoplastic elastomer , PDMS, Polydimethyl siloxane, Fast core propellant, Co-layered, Wall slip, Shear...first opportunity possible, the steady FEM models of SIT will need to be converted into time dependent models to allow time dependent calculations to be

Contributions of procoagulants and anticoagulants to the international normalized ratio and thrombin generation assay in patients treated with warfarin: potential role of protein Z as a powerful determinant of coagulation assays.

PubMed

Choi, Qute; Kim, Ji-Eun; Hyun, Jungwon; Han, Kyou-Sup; Kim, Hyun Kyung

2013-07-01

The effects of warfarin are measured with the international normalized ratio (INR). However, the thrombin generation assay (TGA) may offer more information about global coagulation. We analyzed the monitoring performance of the TGA and INR and investigated the impact of procoagulants (fibrinogen, factor (F)II, FVII, FIX, and FX) and anticoagulants (proteins C, S, and Z) on them. The TGA was performed on a calibrated automated thrombogram, producing lag time, endogenous thrombin potential (ETP), and peak thrombin in 239 patients treated with warfarin. Pro- and anticoagulant levels were also measured. The INR was significantly and inversely correlated with ETP. The therapeutic range of ETP comparable to an INR range of 2.0-3.0 was 290.1-494.6. ETP showed comparable performance to the INR as a warfarin-monitoring parameter with respect to clinical complication rate. The median levels of FII, FVII, FIX, and FX and proteins C and Z tended to decrease gradually with increasing anticoagulation intensity according to the INR or ETP. Of note, protein Z levels decreased dramatically with increasing anticoagulation status. INRs were significantly determined by FII, FVII, and protein Z. ETP was significantly dependent on FVII, and proteins C and Z concentration. Protein Z significantly reduced the total amount of thrombin generation and prolonged PT value in vitro. The INR and ETP exhibit similar efficacy for warfarin monitoring according to the clinical complication rate. Protein Z is considered to be a significant determinant of INR and ETP in patients on warfarin therapy. Copyright © 2013 Elsevier Ltd. All rights reserved.

Endogenous Thrombin Potential Changes during the First Cycle of Oral Contraceptive Use

PubMed Central

Westhoff, Carolyn L.; Pike, Malcolm C.; Cremers, Serge; Eisenberger, Andrew; Thomassen, Stella; Rosing, Jan

2017-01-01

Objectives Venous thromboembolism (VTE) risk increases within months of combination oral contraceptive (COC) initiation. Because elevated endogenous thrombin potential (ETP) has been found in several studies to be a VTE risk factor, we evaluated the extent of ETP changes during the initial cycle of an ethinyl estradiol (EE) and levonorgestrel (LNG) COC. We also assessed the relationship between ETP changes and systemic EE and LNG concentrations. Study Design Participants provided multiple blood samples during a first 21-day cycle of a 30 µg EE/150 µg LNG COC and after a further 7 days without an active COC. Thrombin generation measured with and without addition of activated protein C (APC) yielded ETP+APC and ETP−APC and the normalized APC sensitivity ratio (nAPCsr). EE and LNG pharmacokinetic analyses were conducted over 24 hours after the first COC tablet and again at steady state. Results Thrombin generation was determined in 16 of the 17 women who completed the study. Mean ETP−APC increased steadily to 21% above baseline at 24 hours after the 6th COC tablet (COC624; p < 0.001) and to 28% above baseline at steady state (COC21; p < 0.001). Mean ETP+APC increased considerably more – by 54% at COC624 and by 79% at steady state. Mean nAPCsr increased by 28% at COC624 and by 41% at steady state. Higher concentrations of EE or LNG were not correlated with greater increases in ETP. Conclusions ETP increases during the first COC cycle were substantial. Implications The early increases in ETP may provide biological support for the rapid increase in VTE risk during initial COC use. The lack of association between this clotting system perturbation and the systemic EE concentration is surprising and deserves further study. PMID:28088496

Synthesis and Anticancer Activity of Epipolythiodiketopiperazine Alkaloids

PubMed Central

Boyer, Nicolas; Morrison, Karen C.; Kim, Justin; Hergenrother, Paul J.; Movassaghi, Mohammad

2013-01-01

The epipolythiodiketopiperazine (ETP) alkaloids are a highly complex class of natural products with potent anticancer activity. Herein, we report the application of a flexible and scalable synthesis, allowing the construction of dozens of ETP derivatives. The evaluation of these compounds against cancer cell lines in culture allows for the first expansive structure–activity relationship (SAR) to be defined for monomeric and dimeric ETP-containing natural products and their synthetic cognates. Many ETP derivatives demonstrate potent anticancer activity across a broad range of cancer cell lines, and kill cancer cellsviainduction of apoptosis. Several traits thatbode well for the translational potential of the ETP class of natural products includeconcise and efficient synthetic access, potent induction of apoptotic cell death, activity against a wide range of cancer types, and a broad tolerance for modifications at multiple sitesthat should facilitate small-molecule drug development, mechanistic studies, and evaluation in vivo. PMID:23914293

78 FR 79046 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-27

... ETP Holder to define pre-set risk thresholds. The tools are designed to act as a backstop for ETP... one method. The Commission will post all comments on the Commission's Internet Web site ( http://www... Change To Offer Risk Management Tools Designed To Allow ETP Holders To Monitor and Address Exposure to...

The Epipolythiodiketopiperazine Gene Cluster in Claviceps purpurea: Dysfunctional Cytochrome P450 Enzyme Prevents Formation of the Previously Unknown Clapurines.

PubMed

Dopstadt, Julian; Neubauer, Lisa; Tudzynski, Paul; Humpf, Hans-Ulrich

2016-01-01

Claviceps purpurea is an important food contaminant and well known for the production of the toxic ergot alkaloids. Apart from that, little is known about its secondary metabolism and not all toxic substances going along with the food contamination with Claviceps are known yet. We explored the metabolite profile of a gene cluster in C. purpurea with a high homology to gene clusters, which are responsible for the formation of epipolythiodiketopiperazine (ETP) toxins in other fungi. By overexpressing the transcription factor, we were able to activate the cluster in the standard C. purpurea strain 20.1. Although all necessary genes for the formation of the characteristic disulfide bridge were expressed in the overexpression mutants, the fungus did not produce any ETPs. Isolation of pathway intermediates showed that the common biosynthetic pathway stops after the first steps. Our results demonstrate that hydroxylation of the diketopiperazine backbone is the critical step during the ETP biosynthesis. Due to a dysfunctional enzyme, the fungus is not able to produce toxic ETPs. Instead, the pathway end-products are new unusual metabolites with a unique nitrogen-sulfur bond. By heterologous expression of the Leptosphaeria maculans cytochrome P450 encoding gene sirC, we were able to identify the end-products of the ETP cluster in C. purpurea. The thioclapurines are so far unknown ETPs, which might contribute to the toxicity of other C. purpurea strains with a potentially intact ETP cluster.

The Epipolythiodiketopiperazine Gene Cluster in Claviceps purpurea: Dysfunctional Cytochrome P450 Enzyme Prevents Formation of the Previously Unknown Clapurines

PubMed Central

Tudzynski, Paul; Humpf, Hans-Ulrich

2016-01-01

Claviceps purpurea is an important food contaminant and well known for the production of the toxic ergot alkaloids. Apart from that, little is known about its secondary metabolism and not all toxic substances going along with the food contamination with Claviceps are known yet. We explored the metabolite profile of a gene cluster in C. purpurea with a high homology to gene clusters, which are responsible for the formation of epipolythiodiketopiperazine (ETP) toxins in other fungi. By overexpressing the transcription factor, we were able to activate the cluster in the standard C. purpurea strain 20.1. Although all necessary genes for the formation of the characteristic disulfide bridge were expressed in the overexpression mutants, the fungus did not produce any ETPs. Isolation of pathway intermediates showed that the common biosynthetic pathway stops after the first steps. Our results demonstrate that hydroxylation of the diketopiperazine backbone is the critical step during the ETP biosynthesis. Due to a dysfunctional enzyme, the fungus is not able to produce toxic ETPs. Instead, the pathway end-products are new unusual metabolites with a unique nitrogen-sulfur bond. By heterologous expression of the Leptosphaeria maculans cytochrome P450 encoding gene sirC, we were able to identify the end-products of the ETP cluster in C. purpurea. The thioclapurines are so far unknown ETPs, which might contribute to the toxicity of other C. purpurea strains with a potentially intact ETP cluster. PMID:27390873

Multiple Employment Training Programs. Major Overhaul Is Needed. Testimony before the Subcommittee on Employment, Housing, and Aviation, Committee on Government Operations, House of Representatives. Agencies Do Not Know If Their Programs Are Working Effectively.

ERIC Educational Resources Information Center

Crawford, Clarence C.

At least 154 employment training programs (ETP) providing approximately $25 billion in employment training assistance are currently administered by 14 federal agencies. Individually, these programs are all well-intended. Collectively, however, they have been described as bewildering and frightening to clients and confusing to those who operate…

77 FR 36027 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-15

... Rates; and For Investor Tiers 1-3, the applicable rate based on an ETP Holder's qualifying levels. The... applicable Tier, Step Up Tier or Basic Rate and would be based on an ETP Holder's qualifying levels, as...-listed Tape B securities based on an ETP Holder's qualifying levels. $0.0026 per share fee for Tape B...

Clinical significance of early T-cell precursor acute lymphoblastic leukaemia: results of the Tokyo Children's Cancer Study Group Study L99-15.

PubMed

Inukai, Takeshi; Kiyokawa, Nobutaka; Campana, Dario; Coustan-Smith, Elaine; Kikuchi, Akira; Kobayashi, Miyuki; Takahashi, Hiroyuki; Koh, Katsuyoshi; Manabe, Atsushi; Kumagai, Masaaki; Ikuta, Koichiro; Hayashi, Yasuhide; Tsuchida, Masahiro; Sugita, Kanji; Ohara, Akira

2012-02-01

Early T-cell precursor acute lymphoblastic leukaemia (ETP-ALL) is a recently identified subtype of T-ALL with distinctive gene expression and cell marker profiles, poor response to chemotherapy and a very high risk of relapse. We determined the reliability of restricted panel of cell markers to identify EPT-ALL using a previously classified cohort. Then, we applied the cell marker profile that best discriminated ETP-ALL to a cohort of 91 patients with T-ALL enrolled in the Tokyo Children's Cancer Study Group L99-15 study, which included allogeneic stem cell transplantation (allo-SCT) for patients with poor prednisone response. Five of the 91 patients (5·5%) met the ETP-ALL criteria. There were no significant differences in presenting clinical features between these and the remaining 86 patients. Response to early remission induction therapy was inferior in ETP-ALL as compared with T-ALL. The ETP-ALL subgroup showed a significantly poorer event-free survival (4-year rate; 40%) than the T-ALL subgroup (70%, P=0·014). Of note, three of four relapsed ETP-ALL patients survived after allo-SCT, indicating that allo-SCT can be effective for this drug-resistant subtype of T-ALL. © 2011 Blackwell Publishing Ltd.

75 FR 52722 - Taking and Importing of Marine Mammals

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-27

... International Dolphin Conservation Program (IDCP) by Spanish flag purse seine vessels or purse seine vessels operating under Spanish jurisdiction to be imported into the United States. The affirmative finding was... ETP by Spanish- flag purse seine vessels or purse seine vessels operating under Spanish jurisdiction...

Comparing thrombin generation in patients with hemophilia A and patients on vitamin K antagonists.

PubMed

de Koning, M L Y; Fischer, K; de Laat, B; Huisman, A; Ninivaggi, M; Schutgens, R E G

2017-05-01

Essentials It is unknown if hemophilia patients with atrial fibrillation need anticoagulation. Endogenous thrombin potentials (ETP) in hemophilia patients and patients on coumarins were compared. Severe hemophilia patients had comparable ETP to therapeutic international normalized ratio (INR). In non-severe hemophilia, 33% had higher ETP than therapeutic INR and may need anticoagulation. Click to hear Dr Negrier's perspective on global assays for assessing coagulation SUMMARY: Background It is unknown whether patients with hemophilia A with atrial fibrillation require treatment with vitamin K antagonists (VKAs) to the same extent as the normal population. Objective To compare hemostatic potential in hemophilia patients and patients on VKAs using thrombin generation (TG). Methods In this cross-sectional study, TG, initiated with 1pM tissue factor, was measured in 133 patients with severe (FVIII < 1%, n = 15) and non-severe (FVIII 1-50%, n = 118) hemophilia A, 97 patients on a VKA with an international normalized ratio (INR) ≥ 1.5 and healthy controls. Endogenous thrombin potential (ETP) (nm*min) was compared according to FVIII level (< 1%, 1-19% and 20-50%) with healthy controls and patients with sub-therapeutic INR (1.5-1.9) and therapeutic INR (≥ 2.0). Medians and interquartile ranges (IQRs) were calculated. Results Compared with healthy controls (898 [IQR 803-1004]), both hemophilia patients and patients on VKAs had lower median ETPs at 304 (196-449) and 176 (100-250), respectively. ETP was quite similar in severe hemophilia patients (185 [116-307]) and patients with a therapeutic INR (156 [90-225]). Compared with patients with therapeutic INR, ETP in patients with FVIII 1-19% and patients with FVIII 20-50% was higher at 296 (203-430) and 397 (219-632), respectively. All patients with therapeutic INR had an ETP < 400. Considering this threshold, 93% of severe hemophilia patients, 70% of patients with FVIII 1-19% and 52% of patients with FVIII 20-50% had an ETP < 400. Conclusion In severe hemophilia patients, TG was comparable to that in patients with a therapeutic INR. In one-third of non-severe hemophilia patients, TG was higher. These results suggest that anticoagulation therapy should be considered in a substantial proportion of non-severe hemophilia patients. © 2017 International Society on Thrombosis and Haemostasis.

Large-Scale Controls of the Surface Water Balance Over Land: Insights From a Systematic Review and Meta-Analysis

NASA Astrophysics Data System (ADS)

Padrón, Ryan S.; Gudmundsson, Lukas; Greve, Peter; Seneviratne, Sonia I.

2017-11-01

The long-term surface water balance over land is described by the partitioning of precipitation (P) into runoff and evapotranspiration (ET), and is commonly characterized by the ratio ET/P. The ratio between potential evapotranspiration (PET) and P is explicitly considered to be the primary control of ET/P within the Budyko framework, whereas all other controls are often integrated into a single parameter, ω. Although the joint effect of these additional controlling factors of ET/P can be significant, a detailed understanding of them is yet to be achieved. This study therefore introduces a new global data set for the long-term mean partitioning of P into ET and runoff in 2,733 catchments, which is based on in situ observations and assembled from a systematic examination of peer-reviewed studies. A total of 26 controls of ET/P that are proposed in the literature are assessed using the new data set. Results reveal that: (i) factors controlling ET/P vary between regions with different climate types; (ii) controls other than PET/P explain at least 35% of the ET/P variance in all regions, and up to ˜90% in arid climates; (iii) among these, climate factors and catchment slope dominate over other landscape characteristics; and (iv) despite the high attention that vegetation-related indices receive as controls of ET/P, they are found to play a minor and often nonsignificant role. Overall, this study provides a comprehensive picture on factors controlling the partitioning of P, with valuable insights for model development, watershed management, and the assessment of water resources around the globe.

Perceived Autonomy Support in the NIMH RAISE Early Treatment Program.

PubMed

Browne, Julia; Penn, David L; Bauer, Daniel J; Meyer-Kalos, Piper; Mueser, Kim T; Robinson, Delbert G; Addington, Jean; Schooler, Nina R; Glynn, Shirley M; Gingerich, Susan; Marcy, Patricia; Kane, John M

2017-09-01

This study examined perceived support for autonomy-the extent to which individuals feel empowered and supported to make informed choices-among participants in the Recovery After an Initial Schizophrenia Episode Early Treatment Program (RAISE ETP). The aims of this study were to evaluate whether NAVIGATE, the active treatment studied in RAISE ETP, was associated with greater improvements in perceived autonomy support over the two-year intervention, compared with community care, and to examine associations between perceived autonomy support and quality of life and symptoms over time and across treatment groups. This study examined perceived autonomy support among the 404 individuals with first-episode psychosis who participated in the RAISE ETP trial (NAVIGATE, N=223; community care, N=181). Three-level conditional linear growth modeling was used given the nested data structure. The results indicated that perceived autonomy support increased significantly over time for those in NAVIGATE but not in community care. Once treatment began, higher perceived autonomy support was related to higher quality of life at six, 12, and 18 months in NAVIGATE and at 12, 18, and 24 months in community care. Higher perceived autonomy support was related to improved scores on total symptoms and on excited symptoms regardless of treatment group and time. Overall, perceived autonomy support increased in NAVIGATE but not for those in community care and was related to improved quality of life and symptoms across both treatment groups. Future research should examine the impact of perceived autonomy support on a wider array of outcomes, including engagement, medication adherence, and functioning.

76 FR 51943 - Proposed Information Collection; Comment Request; International Dolphin Conservation Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-19

... vessel characteristics and operations in the ETP, the origin of tuna and tuna products, and certain other... origin of tuna (if requested by the NOAA Administrator); 10 hours for an experimental fishing operation... October 18, 2011. ADDRESSES: Direct all written comments to Diana Hynek, Departmental Paperwork Clearance...

77 FR 50086 - Taking and Importing of Marine Mammals

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-20

... International Dolphin Conservation Program (IDCP) by Spanish-flag purse seine vessels or purse seine vessels operating under Spanish jurisdiction to be imported into the United States. The affirmative finding was... derived from yellowfin tuna harvested in the ETP by Spanish-flag purse seine vessels or purse seine...

76 FR 52319 - Taking and Importing of Marine Mammals

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-22

... International Dolphin Conservation Program (IDCP) by Spanish-flag purse seine vessels or purse seine vessels operating under Spanish jurisdiction to be imported into the United States. The affirmative finding was... States of yellowfin tuna and products derived from yellowfin tuna harvested in the ETP by Spanish-flag...

[The Engineering and Technical Services Directorate at the Glenn Research Center

NASA Technical Reports Server (NTRS)

Moon, James

2004-01-01

My name is James Moon and I am a senior at Tennessee State University where my major is Aeronautical and Industrial Technology with a concentration in industrial electronics. I am currently serving my internship in the Engineering and Technical Services Directorate at the Glenn Research Center (GRC). The Engineering and Technical Service Directorate provides the services and infrastructure for the Glenn Research Center to take research concepts to reality. They provide a full range of integrated services including engineering, advanced prototyping and testing, facility management, and information technology for NASA, industry, and academia. Engineering and Technical Services contains the core knowledge in Information Technology (IT). This includes data systems and analysis, inter and intranet based systems design and data security. Including the design and development of embedded real-time s o h a r e applications for flight and supporting ground systems, Engineering and Technical Services provide a wide range of IT services and products specific to the Glenn Research Center research and engineering community. In the 7000 Directorate I work directly in the 7611 organization. This organization is known as the Aviation Environments Technical Branch. My mentor is Vincent Satterwhite who is also the Branch Chief of the Aviation Environments Technical Branch. In this branch, I serve as the Assistant program manager of the Engineering Technology Program. The Engineering Technology Program (ETP) is one of three components of the High School L.E.R.C.I.P. This is an Agency-sponsored, eight-week research-based apprenticeship program designed to attract traditionally underrepresented high school students that demonstrate an aptitude for and interest in mathematics, science, engineering, and technology.

No gene flow across the Eastern Pacific Barrier in the reef-building coral Porites lobata.

PubMed

Baums, Iliana B; Boulay, Jennifer N; Polato, Nicholas R; Hellberg, Michael E

2012-11-01

The expanse of deep water between the central Pacific islands and the continental shelf of the Eastern Tropical Pacific is regarded as the world's most potent marine biogeographic barrier. During recurrent climatic fluctuations (ENSO, El Niño Southern Oscillation), however, changes in water temperature and the speed and direction of currents become favourable for trans-oceanic dispersal of larvae from central Pacific to marginal eastern Pacific reefs. Here, we investigate the population connectivity of the reef-building coral Porites lobata across the Eastern Pacific Barrier (EPB). Patterns of recent gene flow in samples (n = 1173) from the central Pacific and the Eastern Tropical Pacific (ETP) were analysed with 12 microsatellite loci. Results indicated that P. lobata from the ETP are strongly isolated from those in the central Pacific and Hawaii (F(ct) ' = 0.509; P < 0.001). However, samples from Clipperton Atoll, an oceanic island on the eastern side of the EPB, grouped with the central Pacific. Within the central Pacific, Hawaiian populations were strongly isolated from three co-occurring clusters found throughout the remainder of the central Pacific. No further substructure was evident in the ETP. Changes in oceanographic conditions during ENSO over the past several thousand years thus appear insufficient to support larval deliveries from the central Pacific to the ETP or strong postsettlement selection acts on ETP settlers from the central Pacific. Recovery of P. lobata populations in the frequently disturbed ETP thus must depend on local larval sources. © 2012 Blackwell Publishing Ltd.

Life cycle assessment of integrated solid state anaerobic digestion and composting for on-farm organic residues treatment.

PubMed

Li, Yangyang; Manandhar, Ashish; Li, Guoxue; Shah, Ajay

2018-03-20

Driven by the gradual changes in the structure of energy consumption and improvements of living standards in China, the volume of on-farm organic solid waste is increasing. If untreated, these unutilized on-farm organic solid wastes can cause environmental problems. This paper presents the results of a life cycle assessment to compare the environmental impacts of different on-farm organic waste (which includes dairy manure, corn stover and tomato residue) treatment strategies, including anaerobic digestion (AD), composting, and AD followed by composting. The input life cycle inventory data are specific to China. The potential environmental impacts of different waste management strategies were assessed based on their acidification potential (AP), eutrophication potential (EP), global warming potential (GWP), ecotoxicity potential (ETP), and resource depletion (RD). The results show that the preferred treatment strategy for dairy manure is the one that integrated corn stover and tomato residue utilization and solid state AD technologies into the system. The GWP of integrated solid state AD and composting was the least, which is -2900 kg CO 2 eq/ t of dairy manure and approximately 14.8 times less than that of current status (i.e., liquid AD of dairy manure). Solid state AD of dairy manure, corn stover and tomato residues is the most favorable option in terms of AP, EP and ETP, which are more than 40% lower than that of the current status (i.e., AP: 3.11 kg SO 2 , EP: -0.94 kg N, and ETP: -881 CTUe (Comparative Toxic Units ecotoxicity)). The results also show that there is a significant potential for AP, EP, ETP, and GWP reduction, if AD is used prior to composting. The scenario analysis for transportation distance showed that locating the AD plant and composting facility on the farm was advantageous in terms of all the life cycle impact categories. Copyright © 2018 Elsevier Ltd. All rights reserved.

77 FR 42034 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-17

... agent and fund accounting agent for the Fund. \\4\\ See Securities Exchange Act Release No. 63737 (January... exchange-traded notes (``ETNs'', and, collectively with ETFs and ETPs, ``Underlying ETPs'').\\7\\ In contrast...

Dissolution of a new explosive formulation containing TNT and HMX: comparison with octol.

PubMed

Monteil-Rivera, Fanny; Deschamps, Stéphane; Ampleman, Guy; Thiboutot, Sonia; Hawari, Jalal

2010-02-15

GIM (Greener Insensitive Material) is a new explosive formulation made of HMX (51.5%), TNT (40.7%), and a binder, ETPE (7.8%), which is currently investigated by the Canadian Department of National Defense for a wider use by the Army. In the present study, dissolution of GIM in water was measured and compared to the dissolution of octol (HMX/TNT: 70/30). Although the presence of ETPE did not prevent completely TNT and HMX from dissolving, GIM appeared to dissolve more slowly than octol. The ETPE was shown to prevent the formulation particles from collapsing and to retard the dissolution of both TNT and HMX by limiting their exposure to water. In both octol and GIM, the dissolution rate of the particles was governed by the compound(s) that are slower to dissolve, i.e. HMX in octol, and HMX and ETPE in GIM. A model based on Fick's diffusion law allowed fitting well the dissolution data of octol but was less appropriate to fit the data of GIM likely due to a physical rearrangement of the solid upon dissolution. The present findings demonstrate that ETPE in GIM decreases the risks of explosives leakage from particles of the new formulation and should facilitate the collecting of non-exploded GIM particles in training sites.

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

PubMed Central

Goossens, Steven; Radaelli, Enrico; Blanchet, Odile; Durinck, Kaat; Van der Meulen, Joni; Peirs, Sofie; Taghon, Tom; Tremblay, Cedric S.; Costa, Magdaline; Ghahremani, Morvarid Farhang; De Medts, Jelle; Bartunkova, Sonia; Haigh, Katharina; Schwab, Claire; Farla, Natalie; Pieters, Tim; Matthijssens, Filip; Van Roy, Nadine; Best, J. Adam; Deswarte, Kim; Bogaert, Pieter; Carmichael, Catherine; Rickard, Adam; Suryani, Santi; Bracken, Lauryn S.; Alserihi, Raed; Canté-Barrett, Kirsten; Haenebalcke, Lieven; Clappier, Emmanuelle; Rondou, Pieter; Slowicka, Karolina; Huylebroeck, Danny; Goldrath, Ananda W.; Janzen, Viktor; McCormack, Matthew P.; Lock, Richard B.; Curtis, David J.; Harrison, Christine; Berx, Geert; Speleman, Frank; Meijerink, Jules P. P.; Soulier, Jean; Van Vlierberghe, Pieter; Haigh, Jody J.

2015-01-01

Early T-cell precursor leukaemia (ETP-ALL) is a high-risk subtype of human leukaemia that is poorly understood at the molecular level. Here we report translocations targeting the zinc finger E-box-binding transcription factor ZEB2 as a recurrent genetic lesion in immature/ETP-ALL. Using a conditional gain-of-function mouse model, we demonstrate that sustained Zeb2 expression initiates T-cell leukaemia. Moreover, Zeb2-driven mouse leukaemia exhibit some features of the human immature/ETP-ALL gene expression signature, as well as an enhanced leukaemia-initiation potential and activated Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signalling through transcriptional activation of IL7R. This study reveals ZEB2 as an oncogene in the biology of immature/ETP-ALL and paves the way towards pre-clinical studies of novel compounds for the treatment of this aggressive subtype of human T-ALL using our Zeb2-driven mouse model. PMID:25565005

Calculation of water evapoation in arid climates

USDA-ARS?s Scientific Manuscript database

The concept of maximum rate of water evaporation, i.e., potential evapotranspiration (ETp, mm d-1) was introduced by Charles Thornthwaite in 1944 and defined as the water loss from vegetation with wet soil. Methods to calculate ETp are divided into empirical and theoretical, which combine physical c...

78 FR 785 - Self-Regulatory Organizations; NYSE Arca, Inc.; Order Granting Approval of Proposed Rule Change...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-04

...; securities; options on securities and indices; futures contracts; options on futures contracts; forward... options, futures, or options on futures on, Shares through ETP Holders, in connection with such ETP... pool operator with the Commodity Futures Trading Commission (``CFTC'') and is a member of the National...

A Survey of English-Medium Instruction in Italian Higher Education

ERIC Educational Resources Information Center

Costa, Francesca; Coleman, James A.

2013-01-01

English-taught Programmes (ETPs) have increased exponentially in European universities over the last 10 years, leading to growing numbers of bilingual graduates. This study reports on the most recent survey of ETPs in Italian higher education. A questionnaire completed in 2010 by 50% of Italian universities addressed both organisational factors…

77 FR 34445 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-11

... Outsourcing Solutions, Inc. as an NYSE Arca ETP Holder and OTP Holder, Subject to Apex Clearing Complying With... Corporation, f/k/a Ridge Clearing and Outsourcing Solutions, Inc. (``Apex Clearing'') as an NYSE Arca ETP... Clearing & Outsourcing Solutions, Inc. Prior to the transaction, Ridge Clearing & Outsourcing Solutions...

Plant Line Trial Evaluation of Viable Non-Chromium Passivation Systems for Electrolytin Tinplate, ETP (TRP 9911)

DOE Office of Scientific and Technical Information (OSTI.GOV)

John A. Sinsel

2003-06-30

Plant trial evaluations have been completed for two zirconium-based, non-chromium passivation systems previously identified as possible alternatives to cathodic dichromate (CDC) passivation for electrolytic tinplate (ETP). These trials were done on a commercial electrolytic tin plating line at Weirton Steel and extensive evaluations of the materials resulting from these trials have been completed. All this was accomplished as a collaborative effort under the AISI Technology Roadmap Program and was executed by seven North American Tin Mill Products producers [Bethlehem Steel (now acquired by International Steel Group (ISG)), Dofasco Inc., National Steel (now acquired by U.S. Steel), U.S. Steel, USS-Posco, Weirtonmore » Steel, and Wheeling-Pittsburgh Steel] with funding partially from the Department of Energy (DOE) and partially on an equal cost sharing basis among project participants. The initial phases of this project involved optimization of application procedures for the non-chromium systems in the laboratories at Bethlehem Steel and Betz Dearborn followed by extensive testing with various lacquer formulations and food simulants in the laboratories at Valspar and PPG. Work was also completed at Dofasco and Weirton Steel to develop methods to prevent precipitation of insoluble solids as a function of time from the zirconate system. The results of this testing indicated that sulfide staining characteristics for the non-chromium passivation systems could be minimized but not totally eliminated and neither system was found to perform quite as good, in this respect, as the standard CDC system. As for the stability of zirconate treatment, a method was developed to stabilize this system for a sufficient period of time to conduct plant trial evaluations but, working with a major supplier of zirconium orthosulfate, a method for long term stabilization is still under development.« less

76 FR 33795 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-09

... with respect to ETP Holders and the equities business of the Exchange that was lost with the... respect to ETP Holders and the equities business of the Exchange. The Exchange will monitor the amount of... raise revenue related to the amount of equity business conducted, which correlates more closely with the...

77 FR 23303 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-18

... the Order Audit Trail System Information Barriers Put Into Place by the ETP Holder in Reliance on... report to the Order Audit Trail System (``OATS'') information barriers put into place by the ETP Holder... uses an effective system of internal controls--such as appropriate information barriers--that operate...

Poorly cemented coral reefs of the eastern tropical Pacific: possible insights into reef development in a high-CO2 world.

PubMed

Manzello, Derek P; Kleypas, Joan A; Budd, David A; Eakin, C Mark; Glynn, Peter W; Langdon, Chris

2008-07-29

Ocean acidification describes the progressive, global reduction in seawater pH that is currently underway because of the accelerating oceanic uptake of atmospheric CO(2). Acidification is expected to reduce coral reef calcification and increase reef dissolution. Inorganic cementation in reefs describes the precipitation of CaCO(3) that acts to bind framework components and occlude porosity. Little is known about the effects of ocean acidification on reef cementation and whether changes in cementation rates will affect reef resistance to erosion. Coral reefs of the eastern tropical Pacific (ETP) are poorly developed and subject to rapid bioerosion. Upwelling processes mix cool, subthermocline waters with elevated pCO(2) (the partial pressure of CO(2)) and nutrients into the surface layers throughout the ETP. Concerns about ocean acidification have led to the suggestion that this region of naturally low pH waters may serve as a model of coral reef development in a high-CO(2) world. We analyzed seawater chemistry and reef framework samples from multiple reef sites in the ETP and found that a low carbonate saturation state (Omega) and trace abundances of cement are characteristic of these reefs. These low cement abundances may be a factor in the high bioerosion rates previously reported for ETP reefs, although elevated nutrients in upwelled waters may also be limiting cementation and/or stimulating bioerosion. ETP reefs represent a real-world example of coral reef growth in low-Omega waters that provide insights into how the biological-geological interface of coral reef ecosystems will change in a high-CO(2) world.

50 CFR 216.92 - Dolphin-safe requirements for tuna harvested in the ETP by large purse seine vessels.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Dolphin-safe requirements for tuna... MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS Dolphin Safe Tuna Labeling § 216.92 Dolphin-safe requirements for tuna harvested in the ETP by large purse seine vessels. (a) U.S...

50 CFR 216.92 - Dolphin-safe requirements for tuna harvested in the ETP by large purse seine vessels.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Dolphin-safe requirements for tuna... MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS Dolphin Safe Tuna Labeling § 216.92 Dolphin-safe requirements for tuna harvested in the ETP by large purse seine vessels. (a) U.S...

50 CFR 216.92 - Dolphin-safe requirements for tuna harvested in the ETP by large purse seine vessels.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 10 2012-10-01 2012-10-01 false Dolphin-safe requirements for tuna... MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS Dolphin Safe Tuna Labeling § 216.92 Dolphin-safe requirements for tuna harvested in the ETP by large purse seine vessels. (a) U.S...

50 CFR 216.92 - Dolphin-safe requirements for tuna harvested in the ETP by large purse seine vessels.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 10 2014-10-01 2014-10-01 false Dolphin-safe requirements for tuna... MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS Dolphin Safe Tuna Labeling § 216.92 Dolphin-safe requirements for tuna harvested in the ETP by large purse seine vessels. (a) U.S...

50 CFR 216.92 - Dolphin-safe requirements for tuna harvested in the ETP by large purse seine vessels.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 10 2013-10-01 2013-10-01 false Dolphin-safe requirements for tuna... MAMMALS REGULATIONS GOVERNING THE TAKING AND IMPORTING OF MARINE MAMMALS Dolphin Safe Tuna Labeling § 216.92 Dolphin-safe requirements for tuna harvested in the ETP by large purse seine vessels. (a) U.S...

77 FR 2293 - AmeriGas Propane, L.P., AmeriGas Propane, Inc., Energy Transfer Partners, L.P., and Energy...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-17

... GP in which AmeriGas proposed to acquire ETP's Heritage Propane business through the approximately $2..., Titan Energy Partner, L.P., and Titan Energy GP, L.L.C. ETP's Heritage Propane business includes Heritage Propane Express, an entity that is engaged in the business of preparing, filling, distributing and...

Real-time echocardiogram transmission protocol based on regions and visualization modes.

PubMed

Cavero, Eva; Alesanco, Álvaro; García, José

2014-09-01

This paper proposes an Echocardiogram Transmission Protocol (ETP) for real-time end-to-end transmission of echocardiograms over IP networks. The ETP has been designed taking into account the echocardiogram characteristics of each visualized region, encoding each region according to its data type, visualization characteristics and diagnostic importance in order to improve the coding and thus the transmission efficiency. Furthermore, each region is sent separately and different error protection techniques can be used for each region. This leads to an efficient use of resources and provides greater protection for those regions with more clinical information. Synchronization is implemented for regions that change over time. The echocardiogram composition is different for each device. The protocol is valid for all echocardiogram devices thanks to the incorporation of configuration information which includes the composition of the echocardiogram. The efficiency of the ETP has been proved in terms of the number of bits sent with the proposed protocol. The codec and transmission rates used for the regions of interest have been set according to previous recommendations. Although the saving in the codified bits depends on the video composition, a coding gain higher than 7% with respect to without using ETP has been achieved.

The sirodesmin biosynthetic gene cluster of the plant pathogenic fungus Leptosphaeria maculans.

PubMed

Gardiner, Donald M; Cozijnsen, Anton J; Wilson, Leanne M; Pedras, M Soledade C; Howlett, Barbara J

2004-09-01

Sirodesmin PL is a phytotoxin produced by the fungus Leptosphaeria maculans, which causes blackleg disease of canola (Brassica napus). This phytotoxin belongs to the epipolythiodioxopiperazine (ETP) class of toxins produced by fungi including mammalian and plant pathogens. We report the cloning of a cluster of genes with predicted roles in the biosynthesis of sirodesmin PL and show via gene disruption that one of these genes (encoding a two-module non-ribosomal peptide synthetase) is essential for sirodesmin PL biosynthesis. Of the nine genes in the cluster tested, all are co-regulated with the production of sirodesmin PL in culture. A similar cluster is present in the genome of the opportunistic human pathogen Aspergillus fumigatus and is most likely responsible for the production of gliotoxin, which is also an ETP. Homologues of the genes in the cluster were also identified in expressed sequence tags of the ETP producing fungus Chaetomium globosum. Two other fungi with publicly available genome sequences, Magnaporthe grisea and Fusarium graminearum, had similar gene clusters. A comparative analysis of all four clusters is presented. This is the first report of the genes responsible for the biosynthesis of an ETP. Copyright 2004 Blackwell Publishing Ltd

78 FR 44609 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing of Proposed Rule Change To List...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-24

... company; taking over control of a company (leveraged buyout); temporary refinancing; or financing internal... in the U.S. on registered exchanges. While a Fund may invest in inverse ETPs, a Fund will not invest in leveraged (e.g., 2X or 3X) or leveraged inverse ETPs. \\30\\ ETNs are debt obligations of investment...

78 FR 21681 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing of Proposed Rule Change and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-11

... calculate an estimated intraday NAV. Such traders understand what the intrinsic per-share price is, hedge... granting the Existing Relief rests on the premise that the prices of ETP shares closely track their per... number of shares of the ETP that are outstanding. The Annual Fee ranges from $5,000 to $55,000. \\6\\ The...

Preparation of enteric coated timed-release press-coated tablets and evaluation of their function by in vitro and in vivo tests for colon targeting.

PubMed

Fukui, E; Miyamura, N; Uemura, K; Kobayashi, M

2000-08-25

As a new oral drug delivery system for colon targeting, enteric coated timed-release press-coated tablets (ETP tablets) were developed by coating enteric polymer on timed-release press-coated tablets composed of an outer shell of hydroxypropylcellulose and core tablet containing diltiazem hydrochloride (DIL) as a model drug. The results of the in vitro dissolution tests in JP 1st fluid (pH 1.2) and JP 2nd fluid (pH 6.8) indicated that these tablets showed both acid resistance and timed-release. To clarify whether ETP tablets could have been of use in the gastrointestinal tract, ETP tablets with a layer of phenylpropanolamine hydrochloride (PPA) (a marker of gastric emptying) between the enteric coating layer and outer shell were prepared, and were administered to beagle dogs. The gastric emptying time and lag time after gastric emptying were evaluated by determining the times at which PPA and DIL first appeared in the plasma (TFA(PPA) and TFA(DIL), respectively). TFA(PPA) and TFA(DIL) were about 4 and 7 h, respectively. This value of TFA(PPA) indicated that ETP tablets displayed acid resistance in the stomach as well as in JP Ist fluid. Subtraction of TFA(PPA) from TFA(DIL) gave a value of about 3 h which agreed well with the lag time determined by in vitro dissolution test in JP 2nd fluid. Also, the results seemed to be in accordance with the time at which the tablets reached the colon after gastric emptying. Therefore, ETP tablets seemed to be an effective tool for oral site-specific delivery including targeting of the colon.

A Systematic Review and Meta-Analysis of the Partitioning of Precipitation over Land

NASA Astrophysics Data System (ADS)

Padrón, Ryan S.; Gudmundsson, Lukas; Greve, Peter; Seneviratne, Sonia I.

2017-04-01

Long-term mean Precipitation (P) over land is partitioned into runoff (R) and evapotranspiration (ET). The aridity index, defined as the ratio between potential ET and P, constitutes the first order control of this partitioning (i.e. ET/P) within Budyko's framework. However, second order controls of ET/P can be significant, and their understanding remains a fundamental challenge. This study therefore introduces a new global observation-based dataset for the long-term mean partitioning of P into ET and R in approximately 2000 catchments, which is obtained from a systematic examination of 170 peer-reviewed studies. The new dataset serves as a basis to improve our understanding of these second order controls around the world. A list of 22 indicators of second order controls of ET/P are identified from the literature, and tested for significance using the new dataset. Results reveal that (i) climate type is a dominant control of ET/P, and additional controls vary with climatic region; (ii) climate characteristics and catchment slope dominate over other catchment controls—the phase shift between the seasonal cycle of P and potential ET appears as an important index across all climate types; (iii) despite the high attention that vegetation-related indices receive as controls of ET/P, they were found to be less important and not always significant; and (iv) the fraction of precipitation falling as snow is the most important second order control in regions with snow climate. The process-related insights from this study about the partitioning of P are a valuable asset for model development, watershed management, and the understanding of future water availability around the globe.

Late Holocene Sea Surface Temperature Trends in the Eastern Tropical Pacific

NASA Astrophysics Data System (ADS)

Rustic, G. T.; Koutavas, A.; Marchitto, T. M., Jr.

2015-12-01

The Eastern Tropical Pacific (ETP) is a highly dynamic ocean region capable of exerting influencing on global climate as illustrated by the El Niño-Southern Oscillation (ENSO). The sea surface temperature (SST) history of this region in past millennia is poorly constrained due to the lack of in situ records with appropriate resolution. Here we present a ~2700 year sub-centennially resolved SST reconstruction from Mg/Ca ratios of the planktonic foraminifer Globigerinoides ruber from Galápagos sediments. The ETP SST record exhibits a long-term cooling trend of over 0.2°C/ky that is similar to Northern Hemisphere multi-proxy temperature trends suggesting a common origin, likely due to insolation forcing. The ETP remains in-phase with Northern Hemisphere climate records through the warm Roman Climate Optimum (~0-400CE), cooler Dark Ages Cold Period (~450-850CE), and through the peak warming of the Medieval Climate Anomaly (900-1150 CE) when SST is within error of modern. Following peak MCA, the ETP cooled rapidly and then rebounded at ~1500 CE during the coldest portion of the Little Ice Age. Overall the data suggest an out-of-phase relationship during much of the last millennium, which we attribute to dynamical adjustments consistent with the "dynamical ocean thermostat" mechanism. Further evidence for these dynamical adjustments comes from reconstructions of the east-west zonal SST gradient using existing Mg/Ca SST reconstructions from the western Pacific warm pool. The last millennium has been the most dynamic period over the past 2700 years, with significant (~1 °C) SST variability in the ETP and modulation of the zonal gradient. A combination of dynamical and thermodynamic mechanisms are invoked to explain the region's complex SST history.

External tube pancreatostomy reduces the risk of mortality associated with completion pancreatectomy for symptomatic fistulas complicating pancreaticoduodenectomy.

PubMed

Ribero, Dario; Amisano, Marco; Zimmitti, Giuseppe; Giraldi, Francesco; Ferrero, Alessandro; Capussotti, Lorenzo

2013-02-01

This study aimed to compare the outcome of a pancreas-preserving technique consisting in a two-step procedure (external tube pancreatostomy (ETP) after resection of dehisced anastomosis followed by late anastomosis completion) with that of completion pancreatectomy (CP) for grade C fistulas complicating pancreaticoduodenectomies (PDs). CP is the most commonly performed operation to treat a dehisced pancreato-jejunal anastomosis associated with deteriorating clinical status or hemorrhage. However, mortality of CP is high and long-term consequences are severe. All consecutive patients who underwent PD between 1990 and 2010 were identified. Clinicopathological data, operative details, and outcomes were analyzed. Out of 370 patients, 112 (30.2 %) developed a pancreatic fistula, which was severe (grade C) in 47 cases. Forty-two patients were treated surgically by CP (n = 23; median time following PD, 10 days), ETP (n = 9; median time following PD, 8 days) or other various procedures (n = 10). Indications for re-operation and operative time of CP and ETP (207.5' versus 170', respectively) were similar, while postoperative mortality was significantly higher after CP (43.5 % versus 0 %, p = 0.030). Moreover, the need for a second emergency re-operation was threefold higher after CP than after ETP (39.1 % versus 11.1 %). After a median of 88 days, seven patients completed the pancreato-jejunal anastomosis without major complications or mortality. After a median follow-up of 14 months, none of the ETP patients developed diabetes. External tube pancreatostomy significantly reduces the mortality associated with emergency CP. Thus, it should always be considered when deciding the treatment option in emergency surgery for severe pancreatic fistulas.

Enterotoxigenic Escherichia coli blood group A interactions intensify diarrheal severity.

PubMed

Kumar, Pardeep; Kuhlmann, F Matthew; Chakroborty, Subhra; Bourgeois, A Louis; Foulke-Abel, Jennifer; Tumala, Brunda; Vickers, Tim J; Sack, David A; DeNearing, Barbara; Harro, Clayton D; Wright, W Shea; Gildersleeve, Jeffrey C; Ciorba, Matthew A; Santhanam, Srikanth; Porter, Chad K; Gutierrez, Ramiro L; Prouty, Michael G; Riddle, Mark S; Polino, Alexander; Sheikh, Alaullah; Donowitz, Mark; Fleckenstein, James M

2018-05-17

Enterotoxigenic Escherichia coli (ETEC) infections are highly prevalent in developing countries where clinical presentations range from asymptomatic colonization to severe cholera-like illness. The molecular basis for these varied presentations, that may involve strain-specific virulence features as well as host factors, have not been elucidated. We demonstrate that when challenged with ETEC strain H10407, originally isolated from a case of cholera-like illness, blood group A human volunteers developed severe diarrhea more frequently than individuals from other blood groups. Interestingly, a diverse population of ETEC strains, including H10407, secrete a novel adhesin molecule, EtpA. As many bacterial adhesins also agglutinate red blood cells, we combined the use of glycan arrays, biolayer inferometry, and non-canonical amino acid labeling with hemagglutination studies to demonstrate that EtpA is a dominant ETEC blood group A specific lectin/hemagglutinin. Importantly, we also show that EtpA interacts specifically with glycans expressed on intestinal epithelial cells from blood group A individuals, and that EtpA-mediated bacterial-host interactions accelerate bacterial adhesion and the effective delivery both heat-labile and heat-stable toxins of ETEC. Collectively, these data provide additional insight into the complex molecular basis of severe ETEC diarrheal illness that may inform rational design of vaccines to protect those at highest risk.

Retrospective Evaluation of Accelerate Pheno™ System (AXDX, Version 1.1) for Identification/Antimicrobial Susceptibility Testing (ID/AST) of Gram-Negative Bacilli (GNB) including Carbapenemase-Producing Organisms (CPO) from Seeded Blood Culture Bottles (SBCB) Tested using AXDX PhenoTestTM BC Kits

PubMed Central

Willey, Barbara M; Gascon, Bryan; Lee, Samantha; Koren, Vita; Surangiwala, Salman; Paterson, Aimee; Lo, Pauline; Boyd, David A; Mulvey, Michael; Mazzulli, Tony; Poutanen, Susan M

2017-01-01

Abstract Background AXDX reports ID/AST in <7h from positive blood cultures. Prospective pre-FDA clinical trials were conducted in areas where CPO bacteremia was rare. This study challenged AXDX to detect CPO from SBCB. Methods 53 GNB including 31 CPO (10 KPC, 8 OXA48-type, 4 NDM, 3 GES5, 3 VIM, 1 VIM/GES5, 1 IMP7, 1 SME) were tested in AXDX post SBCB incubation in BacT/Alert® (bioMérieux). Seeding suspensions were parallel-tested by CLSI M100-S27 broth microdilution (BMD) for cefazolin (CFZ), ceftriaxone (CRO), ceftazidime (CAZ), piperacillin/tazobactam (TZP), ertapenem (ETP), meropenem (MEM), ciprofloxacin (CIP), gentamicin (GM), tobramycin (TOB), and amikacin (AN). With GNB-genera combined, AXDX-AST were assessed vs BMD using Cumitech 31A for ≥90% agreements [essential (EA); categorical (CA)] and errors [very major (VME) <3%; combined major/minor (ME/mE) <7%]. Results AXDX produced evaluable results (ID-correct/AST-reported) for 83% GNB (19 Klebsiella species; 13 Escherichia coli; 5 Pseudomonas aeruginosa; 4 Enterobacter cloacae, 2 Proteus mirabilis; 1 Serratia marcescens) tabulated below. Limits were exceeded for underlined values, but 95% confidence intervals (CI) overlapped acceptable limits except in values marked with astericks [95% CI: EA (CRO:58.8–85.6; ETP:31.6–61.4; MEM:62.8–87.3; GEN:48.8–76.3); VME (MEM:11.7–45.2); ME/mE (CAZ:7.8–30.3)]. Of 31 CPO, by BMD/AXDX respectively, 2 (6.5%; P. mirabilis NDM, E. coli KPC)/4 (12.9%; same 2 plus E. cloacae KPC, S. marcescens SME) were ETP+MEM=S, 23 (74.2%)/17 (54.8%) were ETP+MEM=I/R and 6 (19.4%; 5 OXA48; 1 KPC)/12 (38.7%; same plus 14 KPC, 1 NDM, 1 SME) were ETP = I/R but MEM=S. If ETP-I/R alone predicted CPO, BMD/AXDX detected 93.5% (95% CI: 78.3–99.2)/87.1% (95% CI: 70.5–95.5) CPO, respectively (P = 0.6713, NS). But as 3/5 (60%) ETP=R non-CPO were also MEM=S by BMD+AXDX, this rule would incur MEM ME. Conclusion Expert rules based on ETP enabled detection of 87.1% (70.5–95.5%) CPO by AXDX in <7h. But while this rule mitigates MEM VME, it risks introducing MEM ME. Further optimization of AXDX algorithms to distinguish challenging CPO growth patterns associated with low carbapenem MIC from non-CPO is underway. More CPO/non-CPO should be tested to tighten 95% CI obtained in this promising study. Disclosures B. M. Willey, Mount Sinai Hospital: Investigator, Educational support S. M. Poutanen, Accelerate Diagnostics: Research Contractor and Scientific Advisor, Consulting fee and Research support

Outcome for children and young people with Early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003.

PubMed

Patrick, Katharine; Wade, Rachel; Goulden, Nick; Mitchell, Chris; Moorman, Anthony V; Rowntree, Clare; Jenkinson, Sarah; Hough, Rachael; Vora, Ajay

2014-08-01

We investigated the outcome for children and young people with Early T-precursor acute lymphoblastic leukaemia (ETP-ALL), a recently described poor prognosis sub-group of T-ALL, treated on a contemporary protocol, UKALL 2003. After a median follow-up of 4 years and 10 months, the ETP sub-group, representing 16% of T-ALL patients, had non-significantly inferior 5-year event-free survival (76·7% vs. 84·6%, P = 0·2) and overall survival (82·4% vs. 90·9%, P = 0·1), and a higher relapse rate (18·6% vs. 9·6%, P = 0·1) compared to typical T-ALL. ETP-ALL has an intermediate risk outcome, which does not warrant experimental treatment or first remission allogeneic transplant for the group universally. © 2014 John Wiley & Sons Ltd.

Procoagulant imbalance in patients with non-alcoholic fatty liver disease.

PubMed

Tripodi, Armando; Fracanzani, Anna L; Primignani, Massimo; Chantarangkul, Veena; Clerici, Marigrazia; Mannucci, Pier Mannuccio; Peyvandi, Flora; Bertelli, Cristina; Valenti, Luca; Fargion, Silvia

2014-07-01

Non-alcoholic fatty liver disease (NAFLD) is characterized by increased risk of cardiovascular events and liver-fibrosis. Both could be explained by a procoagulant-imbalance that was surmised but never directly demonstrated. We investigated 113 patients with varying histological liver damage [steatosis (n=32), steatohepatitis (n=51), metabolic-cirrhosis (n=30)], 54 with alcoholic/viral-cirrhosis and 179 controls. Plasma was evaluated for levels of pro- and anti-coagulants, and for thrombin-generation assessed as endogenous-thrombin-potential (ETP) with and without thrombomodulin or Protac® as protein C activators. The procoagulant-imbalance was defined as ETP-ratio (with-to-without thrombomodulin) or as Protac®-induced-coagulation-inhibition (PICI%). High ETP-ratios or low PICI% indicate resistance to thrombomodulin or Protac® and hence a procoagulant-imbalance. ETP-ratio increased from controls [0.57 (0.11-0.89)] to steatosis [0.72 (0.33-0.86)] and metabolic-cirrhosis [0.80 (0.57-0.95)], (p<0.001), the latter being comparable to that for alcoholic/viral-cirrhosis [0.80 (0.57-0.95) vs. 0.80 (0.44-0.96)]. Factor VIII (a potent procoagulant for thrombin-generation) increased from steatosis [99% (71-150)] to metabolic-cirrhosis [157% (64-232)], p<0.001. Protein C (a powerful anticoagulant) decreased from steatosis [103% (77-228)] to metabolic-cirrhosis [77 (17-146)], p<0.001. As a consequence, factor VIII-to-protein C ratio increased from steatosis [0.96 (0.36-1.60)] to metabolic-cirrhosis [2.05 (0.81-12.1)], p<0.001 and was correlated with the ETP-ratio (rho=0.543, p<0.001). Similar results were obtained for PICI%. Patients with procoagulant-imbalance detected as ETP-ratio greater or PICI% lower than the median value of controls tended to have a higher risk of metabolic-syndrome, higher intima-media thickness, fibrosis, steatosis or lobular inflammation, all considered clinical manifestations of NAFLD. NAFLD is characterized by a procoagulant-imbalance progressing from the less severe (steatosis) to the most severe form of the disease (metabolic-cirrhosis). This imbalance appears to result from increased factor VIII and reduced protein C and might play a role in the risk of cardiovascular events and liver-fibrosis commonly observed in NAFLD. Copyright © 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

Incomes and Outcomes: Social Security Disability Benefits in First-Episode Psychosis.

PubMed

Rosenheck, Robert A; Estroff, Sue E; Sint, Kyaw; Lin, Haiqun; Mueser, Kim T; Robinson, Delbert G; Schooler, Nina R; Marcy, Patricia; Kane, John M

2017-09-01

Social Security Administration (SSA) disability benefits are an important source of income for people with psychoses and confer eligibility for health insurance. The authors examined the impact of coordinated specialty care on receipt of such benefits in first-episode psychosis, along with the correlates and consequences of receiving them. The Recovery After an Initial Schizophrenia Episode-Early Treatment Program (RAISE-ETP) study, a 34-site cluster-randomized trial, compared NAVIGATE, a coordinated specialty care program, to usual community care over 2 years. Receipt of SSA benefits and clinical outcomes were assessed at program entry and every 6 months for 2 years. Piecewise regression analysis was used to identify relative change in outcome trajectories after receipt of disability benefits. Among 399 RAISE-ETP participants, 36 (9%) were receiving SSA disability benefits at baseline; of the remainder, 124 (34.1%) obtained benefits during the 2-year study period. The NAVIGATE intervention improved quality of life, symptoms, and employment but did not significantly reduce the likelihood of receiving SSA disability benefits. Obtaining benefits was predicted by more severe psychotic symptoms and greater dysfunction and was followed by increased total income but fewer days of employment, reduced motivation (e.g., sense of purpose, greater anhedonia), and fewer days of intoxication. A 2-year coordinated specialty care intervention did not reduce receipt of SSA disability benefits. There were some advantages for those who obtained SSA disability benefits over the 2-year treatment period, but there were also some unintended adverse consequences. Providing income supports without impeding recovery remains an important policy challenge.

New insights into enterocin CRL35: mechanism of action and immunity revealed by heterologous expression in Escherichia coli.

PubMed

Barraza, Daniela E; Ríos Colombo, Natalia S; Galván, Adriana E; Acuña, Leonardo; Minahk, Carlos J; Bellomio, Augusto; Chalón, Miriam C

2017-09-01

The role of the class IIa bacteriocin membrane receptor protein remains unclear, and the following two different mechanisms have been proposed: the bacteriocin could interact with the receptor changing it to an open conformation or the receptor might act as an anchor allowing subsequent bacteriocin insertion and membrane disruption. Bacteriocin-producing cells synthesize an immunity protein that forms an inactive bacteriocin-receptor-immunity complex. To better understand the molecular mechanism of enterocin CRL35, the peptide was expressed as the suicidal probe EtpM-enterocin CRL35 in Escherichia coli, a naturally insensitive microorganism since it does not express the receptor. When the bacteriocin is anchored to the periplasmic face of the plasma membrane through the bitopic membrane protein, EtpM , E. coli cells depolarize and die. Moreover, co-expression of the immunity protein prevents the deleterious effect of EtpM-enterocin CRL35. The binding and anchoring of the bacteriocin to the membrane has demonstrated to be a sufficient condition for its membrane insertion. The final step of membrane disruption by EtpM-enterocin CRL35 is independent from the receptor, which means that the mannose PTS might not be involved in the pore structure. In addition, the immunity protein can protect even in the absence of the receptor. © 2017 John Wiley & Sons Ltd.

Electronically transmitted prescriptions not picked up at pharmacies in Sweden.

PubMed

Ax, Fredrik; Ekedahl, Anders

2010-03-01

Electronically transmitted prescriptions (ETPs) became common after 1995 in Sweden; however, it is accompanied by a substantial increase in the number of prescriptions not picked up at pharmacies. To investigate the "no pick-up" rates of ETPs at pharmacies across type of drug and patient age and gender and the reasons patients' report for no pick-up. A cross-sectional study examining no pick-up of ETPs transmitted during 3 months in 2002, and a mail survey of patients to determine the reasons for failure to pick-up in the county of Sörmland, Sweden, with a population of 261,000, and 21 pharmacies. Chi-square tests were used for calculations of frequency differences among groups. The overall no pick-up rate of ETPs was 2.5%; men had consistently higher rates than women. The highest rates were seen for adolescents and young adults. Rates were higher than average for antibiotics. About 60% of the answers indicated that prescriptions not picked up were duplicate prescriptions or not needed. "Unintentional nonadherence" was reported by one-fifth of patients. No pick-up rate in general was low (2.5%), but there were differences across patient age and gender, the rates being higher among adolescents and young adults. Duplicate prescriptions may explain a significant share of the abandoned prescriptions. Copyright 2010 Elsevier Inc. All rights reserved.

In vivo increase in thrombin generation by four-factor prothrombin complex concentrate in apixaban-treated healthy volunteers.

PubMed

Cheung, Y W; Barco, S; Hutten, B A; Meijers, J C M; Middeldorp, S; Coppens, M

2015-10-01

Four-factor prothrombin complex concentrate (PCC) (Cofact; Sanquin Blood Supply) 50 IU kg(-1) increased thrombin generation beyond baseline values in healthy, rivaroxaban-treated subjects. To assess whether infusion with doses of 37.5 IU kg(-1) and 25 IU kg(-1) PCC reverses the anticoagulant effect of high-dose apixaban, another oral direct factor Xa inhibitor. In a randomized, double-blind, placebo-controlled, crossover study, six healthy subjects received twice-daily apixaban 10 mg for 3.5 days followed by a single bolus of 37.5 IU kg(-1) PCC, 25 IU kg(-1) PCC, or placebo. The primary outcome was the effect of PCC 15 min after infusion on thrombin generation (endogenous thrombin potential [ETP]); secondary outcomes were the immediate effect of PCC on prothrombin time (PT) and the effect of PCC as compared with placebo over a period of 24 h on ETP and PT. Fifteen minutes after infusion of 37.5 IU kg(-1) and 25 IU kg(-1) PCC, ETP increased from 41% ± 11% to 56% ± 23% (P = 0.06) and from 44% ± 12% to 51% ± 15% (P = 0.03), respectively. ETP significantly differed over time between 37.5 IU kg(-1) PCC and placebo during 24 h after infusion (P < 0.01). Both PCC doses restored apixaban-induced PT prolongation after 15 min (P < 0.01), and this was sustained over a period of 24 h. Both 37.5 IU kg(-1) PCC and 25 IU/kg PCC improved coagulation parameters in healthy subjects, suggesting partial reversal of the anticoagulant effect of apixaban. This implies that PCC might be considered in patients with apixaban-associated bleeding. However, ETP was not immediately restored to pre-apixaban levels, suggesting that these doses are too low to instantly and fully restore hemostasis at peak apixaban levels. © 2015 International Society on Thrombosis and Haemostasis.

Comparison of outpatient and home-based exercise training programmes for COPD: A systematic review and meta-analysis.

PubMed

Wuytack, Francesca; Devane, Declan; Stovold, Elizabeth; McDonnell, Melissa; Casey, Michelle; McDonnell, Timothy J; Gillespie, Paddy; Raymakers, Adam; Lacasse, Yves; McCarthy, Bernard

2018-03-01

Chronic obstructive pulmonary disease is a common, preventable and treatable disease. Exercise training programmes (ETPs) improve symptoms, health-related quality of life (HRQoL) and exercise capacity, but the optimal setting is unknown. In this review, we compared the effects of ETPs in different settings on HRQoL and exercise capacity. We searched (5 July 2016) the Cochrane Airways Group Specialised Register, ClinicalTrials.gov and World Health Organization trials portal. We selected studies, extracted data and assessed risk of bias with two independent reviewers. We calculated mean differences (MD) with 95% CI. We assessed the quality of evidence using Grades of Recommendation, Assessment, Development and Evaluation. Ten trials (934 participants) were included. Hospital (outpatient) and home-based ETPs (seven trials) were equally effective at improving HRQoL on the Chronic Respiratory Questionnaire (CRQ) (dyspnoea: MD -0.09, 95% CI: -0.28 to 0.10; fatigue: MD -0.00, 95% CI: -0.18 to 0.17; emotional: MD 0.10, 95% CI: -0.24 to 0.45; and mastery: MD -0.02, 95% CI: -0.28 to 0.25; moderate quality) and on the St George's Respiratory Questionnaire (SGRQ) (MD -0.82, 95% CI: -7.47 to 5.83, low quality). Hospital (outpatient) and community-based ETPs (three trials) were equally effective at improving HRQoL (CRQ dyspnoea: MD 0.29, 95% CI: -0.05 to 0.62, moderate quality; fatigue: MD -0.02, 95% CI: -1.09 to 1.05, low quality; emotional: MD 0.10, 95% CI: -0.40 to 0.59, moderate quality; and mastery: MD -0.08, 95% CI: -0.45 to 0.28, moderate quality). There was no difference in exercise capacity. There was low to moderate evidence that outpatient and home-based ETPs are equally effective. See related Editorial. © 2017 Asian Pacific Society of Respirology.

Quarantine versus pathogen-reduced plasma-coagulation factor content and rotational thromboelastometry coagulation.

PubMed

Theusinger, Oliver M; Goslings, David; Studt, Jan-Dirk; Brand-Staufer, Brigitte; Seifert, Burkhardt; Spahn, Donat R; Frey, Beat M

2017-03-01

Different types of fresh-frozen plasma (FFP) exist, and the concentrations of plasma proteins vary between individuals and blood groups. Furthermore, processing may also influence the content. Quarantine-stored plasma (qFFP) and plasma that was pathogen-reduced using blood-safety (Intercept) technology (piFFP) were analyzed regarding procoagulant and anticoagulant hemostasis proteins, including endogenous thrombin (thrombin-generation) potential (ETP). Thirty-five samples of each type of FFP were analyzed using only male Blood Group O donors. FFP units were stored frozen for comparable periods of time before plasma protein content was assessed. Once the units were thawed, all tests were completed within 4 hours. The results are presented as means ± standard deviations or as median (minimum; maximum) and were compared using independent-sample t tests (significance, p < 0.01). Significantly higher concentrations of adintegrin-like and metalloprotease with thrombospondin type-13 motifs (ADAMTS13), fibrinogen, Factor (F)V, FVIII, FXIII, protein S, protein S activity, antithrombin, microvesicle (<900 nm), and α2 antiplasmin were observed in qFFP. The variability of factors was significantly lower in piFFP. Tissue factor (TF) at 1 picomolar (pM) exhibited significantly longer lag time, a lower peak, lower ETP, and a lower velocity index in qFFP compared with piFFP. In TF at 5 pM, significant differences in lag time (longer in qFFP), velocity index (lower in qFFP), and peak (lower in qFFP) were observed. Rotational thromboelastometry revealed a significantly longer (p = 0.002) clot-formation time with intrinsic thromboelastometry for piFFP and a significantly shorter clotting time (p = 0.004) with thromboelastometry fibrinogen testing for piFFP. Pathogen reduction reduces procoagulant and anticoagulant coagulation factors as well as variability. A thrombin-generation assay showed no reduced ETP and no supraphysiological thrombin generation. None of the FFP preparations is likely to be effective for treating fibrinogen deficiency. © 2016 AABB.

Calorimetry of 25 Ah lithium/thionyl chloride cells

NASA Technical Reports Server (NTRS)

Johnson, C. J.; Dawson, S.

1991-01-01

Heat flow measurements of 25-Ah lithium thionyl chloride cells provided a method to calculate an effective thermal potential, E(TP) of 3.907 V. The calculation is useful to determine specific heat generation of this cell chemistry and design. The E(TP) value includes heat generation by electrochemical cell reactions, competitive chemical reactions, and resistance heating at the tabs, connectors, and leads. Heat flow was measured while applying electrical loads to the cell in an isothermal calorimeter set at 0, 20, and 60 C.

Characterization Results for the January 2017 H-Tank Farm 2H Evaporator Overhead Sample

DOE Office of Scientific and Technical Information (OSTI.GOV)

Truong, T.; Nicholson, J.

2017-04-11

This report contains the radioanalytical results of the 2H evaporator overhead sample received at SRNL on January 19, 2017. Specifically, concentrations of 137Cs, 90Sr, and 129I are reported and compared to the corresponding Waste Acceptance Criteria (WAC) limits of the Effluent Treatment Project (ETP) Waste Water Collection Tank (WWCT) (rev. 6). All of the radionuclide concentrations in the sample were found to be in compliance with the ETP WAC limits.

Characterization Results For The 2013 HTF 3H Evaporator Overhead Samples

DOE Office of Scientific and Technical Information (OSTI.GOV)

Washington, A. L. II

2013-12-04

This report tabulates the radiochemical analysis of the 3H evaporator overhead sample for {sup 137}Cs, {sup 90}Sr, and {sup 129}I to meet the requirements in the Effluent Treatment Project (ETP) Waste Acceptance Criteria (WAC) (rev. 6). This report identifies the sample receipt date, preparation method, and analysis performed in the accumulation of the listed values. All data was found to be within the ETP WAC (rev. 6) specification for the Waste Water Collection Tanks (WWCT).

Characterization results for the October 2015-Tank for farm 3H evaporator overhead examples

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nicholson, J. C.

2016-01-28

This report contains the radioanalytical results of the 3H evaporator overhead sample received at SRNL on October 13, 2015. Specifically, concentrations of 137Cs, 90Sr, and 129I are reported and compared to the corresponding Waste Acceptance Criteria (WAC) limits of the Effluent Treatment Project (ETP) Waste Water Collection Tank (WWCT) (rev. 6). All of the radionuclide concentrations in the sample were found to be in compliance with the ETP WAC limits.

Characterization Results for the March 2016 H-Tank Farm 2H Evaporator Overhead Samples

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nicholson, J. C.

2016-05-09

This report contains the radioanalytical results of the 2H evaporator overhead sample received at SRNL on March 16, 2016. Specifically, concentrations of 137Cs, 90Sr, and 129I are reported and compared to the corresponding Waste Acceptance Criteria (WAC) limits of the Effluent Treatment Project (ETP) Waste Water Collection Tank (WWCT) (rev. 6). All of the radionuclide concentrations in the sample were found to be in compliance with the ETP WAC limits.

Characterization Results for the 2014 HTF 3H & 2H Evaporator Overhead Samples

DOE Office of Scientific and Technical Information (OSTI.GOV)

Washington, A.

2015-05-11

This report tabulates the radiochemical analysis of the 3H and 2H evaporator overhead samples for 137Cs, 90Sr, and 129I to meet the requirements in the Effluent Treatment Project (ETP) Waste Acceptance Criteria (WAC) (rev. 6). This report identifies the sample receipt date, preparation method, and analysis performed in the accumulation of the listed values. All data was found to be within the ETP WAC (rev. 6) specification for the Waste Water Collection Tanks (WWCT).

Comparative analysis of ERCP, IDUS, EUS and CT in predicting malignant bile duct strictures

PubMed Central

Heinzow, Hauke S; Kammerer, Sara; Rammes, Carina; Wessling, Johannes; Domagk, Dirk; Meister, Tobias

2014-01-01

AIM: To compare endoscopic retrograde cholangio-pancreatography (ERCP), intraductal ultrasound (IDUS), endosonography (EUS), endoscopic transpapillary forceps biopsies (ETP) and computed tomography (CT) with respect to diagnosing malignant bile duct strictures. METHODS: A patient cohort with bile duct strictures of unknown etiology was examined by ERCP and IDUS, ETP, EUS, and CT. The sensitivity, specificity, and accuracy rates of the diagnostic procedures were calculated based on the definite diagnoses proved by histopathology or long-term follow-up in those patients who did not undergo surgery. For each of the diagnostic measures, the sensitivity, specificity, and accuracy rates were calculated. In all cases, the gold standard was the histopathologic staging of specimens or long-term follow-up of at least 12 mo. A comparison of the accuracy rates between the localization of strictures was performed by using the Mann-Whitney U-test and the χ2 test as appropriate. A comparison of the accuracy rates between the diagnostic procedures was performed by using the McNemar’s test. Differences were considered statistically significant if P < 0.05. RESULTS: A total of 234 patients (127 males, 107 females, median age 64, range 20-90 years) with indeterminate bile duct strictures were included. A total of 161 patients underwent operative exploration; thus, a surgical histopathological correlation was available for those patients. A total of 113 patients had malignant disease proven by surgery; in 48 patients, benign disease was surgically found. In these patients, the decision for surgical exploration was made due to the suspicion of malignant disease in multimodal diagnostics (ERCP, CT, or EUS). Fifty patients had a benign diagnosis and were followed by a surveillance protocol with a follow-up of at least 12 mo; the median follow-up was 34 mo. Twenty-three patients had extended malignant disease, and thus were considered palliative. A comparison of the different diagnostic tools for detecting bile duct malignancy resulted in accuracy rates of 91% (ERCP/IDUS), 59% (ETP), 92% (IDUS + ETP), 74% (EUS), and 73% (CT), respectively. In the subgroup analysis, the accuracy rates (%, ERCP + IDUS/ETP/IDUS + ETP; EUS; CT) for each tumor entity were as follows: cholangiocellular carcinoma: 92%/74%/92%/70%/79%; pancreatic carcinoma: 90%/68%/90%/81%/76%; and ampullary carcinoma: 88%/90%/90%/76%/76%. The detection rate of malignancy by ERCP/IDUS was superior to ETP (91% vs 59%, P < 0.0001), EUS (91% vs 74%, P < 0.0001) and CT (91% vs 73%, P < 0.0001); EUS was comparable to CT (74% vs 73%, P = 0.649). When analyzing accuracy rates with regard to localization of the bile duct stenosis, the accuracy rate of EUS for proximal vs distal stenosis was significantly higher for distal stenosis (79% vs 57%, P < 0.0001). CONCLUSION: ERCP/IDUS is superior to EUS and CT in providing accurate diagnoses of bile duct strictures of uncertain etiology. Multimodal diagnostics is recommended. PMID:25132767

Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation

PubMed Central

Maillard, Ivan; Schwarz, Benjamin A.; Sambandam, Arivazhagan; Fang, Terry; Shestova, Olga; Xu, Lanwei; Bhandoola, Avinash; Pear, Warren S.

2006-01-01

Early T-lineage progenitors (ETPs) arise after colonization of the thymus by multipotent bone marrow progenitors. ETPs likely serve as physiologic progenitors of T-cell development in adult mice, although alternative T-cell differentiation pathways may exist. While we were investigating mechanisms of T-cell reconstitution after bone marrow transplantation (BMT), we found that efficient donor-derived thymopoiesis occurred before the pool of ETPs had been replenished. Simultaneously, T lineage–restricted progenitors were generated at extrathymic sites, both in the spleen and in peripheral lymph nodes, but not in the bone marrow or liver. The generation of these T lineage–committed cells occurred through a Notch-dependent differentiation process. Multipotent bone marrow progenitors efficiently gave rise to extrathymic T lineage–committed cells, whereas common lymphoid progenitors did not. Our data show plasticity of T-lineage commitment sites in the post-BMT environment and indicate that Notch-driven extrathymic Tlineage commitment from multipotent progenitors may contribute to early T-lineage reconstitution after BMT. PMID:16397133

Does daily vitamin D 800 IU and calcium 1000 mg supplementation decrease the risk of falling in ambulatory women aged 65-71 years? A 3-year randomized population-based trial (OSTPRE-FPS).

PubMed

Kärkkäinen, Matti K; Tuppurainen, Marjo; Salovaara, Kari; Sandini, Lorenzo; Rikkonen, Toni; Sirola, Joonas; Honkanen, Risto; Arokoski, Jari; Alhava, Esko; Kröger, Heikki

2010-04-01

The hypothesis was that the calcium and vitamin D supplementation prevents falls at the population level. The OSTPRE-FPS was a randomized population-based open-trial with 3-year follow-up. The supplementation group (n=1566) received daily cholecalciferol 800IU+calcium carbonate 1000mg, while the control group (n=1573) received no supplementation or placebo. A randomly selected subsample of 593 subjects underwent a detailed measurement program including serum 25(OH)D measurements. The occurrence of falls was the primary outcome of the study. The participants in the subsample were telephoned at 4 months intervals and the rest of the trial population was interviewed by phone once a year. In the entire trial population (ETP), there were 812 women with 1832 falls in the intervention group and 833 women with 1944 falls in the control group (risk ratio was 0.98, 95% CI 0.92-1.05, P=0.160). The supplementation was not associated with single or multiple falls in the ETP. However, in the subsample, multiple fall incidence decreased by 30% (odds ratio (OR) 0.70, 95% CI 0.50-0.97, P=0.034) in the supplementation group. Further, the supplementation decreased the incidence of multiple falls requiring medical attention (OR 0.72, 95% CI 0.53-0.97, P=0.031) in the ETP. The mean compliance in the entire trial population was 78% and in the subsample 79%. Overall, the primary analysis showed no association between calcium and vitamin D supplementation and risk of falls. However, the results of a post hoc analysis suggested that there was a decreased risk of multiple falls requiring medical attention: this finding requires confirmation. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

Evaluation of pressurized water cleaning systems for hardware refurbishment

NASA Technical Reports Server (NTRS)

Dillard, Terry W.; Deweese, Charles D.; Hoppe, David T.; Vickers, John H.; Swenson, Gary J.; Hutchens, Dale E.

1995-01-01

Historically, refurbishment processes for RSRM motor cases and components have employed environmentally harmful materials. Specifically, vapor degreasing processes consume and emit large amounts of ozone depleting compounds. This program evaluates the use of pressurized water cleaning systems as a replacement for the vapor degreasing process. Tests have been conducted to determine if high pressure water washing, without any form of additive cleaner, is a viable candidate for replacing vapor degreasing processes. This paper discusses the findings thus far of Engineering Test Plan - 1168 (ETP-1168), 'Evaluation of Pressurized Water Cleaning Systems for Hardware Refurbishment.'

Increased thrombin generation in women with polycystic ovary syndrome: A pilot study on the effect of metformin and oral contraceptives.

PubMed

Glintborg, Dorte; Sidelmann, Johannes J; Altinok, Magda Lambaa; Mumm, Hanne; Andersen, Marianne

2015-10-01

Polycystic ovary syndrome (PCOS) is associated with risk factors for cardiovascular disease (CVD) which may be modified by the use of metformin and oral contraceptives (OC). Thrombin generation (TG) measures are risk markers of CVD and address the composite of multiple factors that influence blood coagulation. This prospective, randomized, intervention study evaluated the potential influence of PCOS on TG measures and the effect of OC and/or metformin on TG measures in women with PCOS. Ninety patients with PCOS and 35 controls were included. Patients were randomized to 12 months of treatment with metformin, metformin+OC or OC alone. C-reactive protein (CRP), fibrinogen, total cholesterol, trunk fat mass, body mass index, estradiol, testosterone, sex hormone binding globulin (SHBG) as well as TG measures, i.e. the lag time for formation of thrombin, the endogenous thrombin potential (ETP), peak thrombin concentration (peak) and time to peak were determined at baseline and after 12 months of treatment. CRP and total testosterone were significantly higher and SHBG significantly lower in PCOS women than in controls (P=0.012, P<0.001 and P=0.008, respectively). The TG measures ETP, peak and lag time were increased in women with PCOS compared to controls (P<0.01). Significant correlations were observed between TG measures and fibrinogen, CRP, SHBG and fat trunk mass (P>0.01). ETP (P=0.006), peak (P=0.003) and lag time (P=0.023) remained increased after adjustment for these potential confounders. Treatment with OC and metformin+OC further increased ETP (P<0.001) and peak (P<0.005) and reduced time to peak (P<0.04). The increase in ETP was significantly lower in the metformin+OC group than in the OC group (P<0.05). Metformin alone did not affect TG significantly. PCOS is associated with increase in TG measures independent of other risk factors of CVD. OC increase TG measures further and may thus add to the increased risk of CVD already present in women with PCOS. Copyright © 2015 Elsevier Inc. All rights reserved.

Reversal of apixaban anticoagulation by four-factor prothrombin complex concentrates in healthy subjects: a randomized three-period crossover study.

PubMed

Song, Y; Wang, Z; Perlstein, I; Wang, J; LaCreta, F; Frost, R J A; Frost, C

2017-11-01

Essentials Prothrombin complex concentrates (PCCs) may reverse the effect of factor Xa (FXa) inhibitors. We conducted an open-label, randomized, placebo-controlled, three-period crossover study in 15 subjects. Both PCCs rapidly reversed apixaban-mediated decreases in mean endogenous thrombin potential. Four-factor PCC administration had no effect on apixaban pharmacokinetics or anti-FXa activity. Background Currently, there is no approved reversal agent for direct activated factor Xa (FXa) inhibitors; however, several agents are under investigation, including prothrombin complex concentrates (PCCs). Objective This open-label, randomized, placebo-controlled, three-period crossover study assessed the effect of two four-factor PCCs on apixaban pharmacodynamics and pharmacokinetics in 15 healthy subjects. Methods Subjects received apixaban 10 mg twice daily for 3 days. On day 4, 3 h after apixaban, subjects received a 30-min infusion of 50 IU kg -1 Cofact, Beriplex P/N (Beriplex), or saline. Change in endogenous thrombin potential (ETP), measured with a thrombin generation assay (TGA), was the primary endpoint. Secondary endpoints included changes in other TGA parameters, prothrombin time (PT), International Normalized Ratio (INR), activated partial thromboplastin time, anti-FXa activity, apixaban pharmacokinetics, and safety. Results Apixaban-related changes in ETP and several other pharmacodynamic measures occurred following apixaban administration. Both PCCs reversed apixaban's effect on ETP; the differences in adjusted mean change from pre-PCC baseline to end of infusion were 425 nm min (95% confidence interval [CI] 219.8-630.7 nm min; P < 0.001) for Cofact, and 91 nm min (95% CI - 31.3 to 212.4 nm min; P > 0.05) for Beriplex. Both PCCs returned ETP to pre-apixaban baseline levels 4 h after PCC infusion, versus 45 h for placebo. For both PCCs, mean ETP peaked 21 h after PCC initiation, and then slowly decreased over the following 48 h. Both PCCs reversed apixaban's effect on TGA peak height, PT, and INR. Apixaban pharmacokinetic and anti-FXa profiles were consistent across treatments. Conclusions Cofact and Beriplex reversed apixaban's steady-state effects on several coagulation assessments. © 2017 International Society on Thrombosis and Haemostasis.

Emission of methane and carbon dioxide and earthworm survival during composting of pharmaceutical sludge and spent mycelia.

PubMed

Majumdar, Deepanjan; Patel, Jigisha; Bhatt, Neha; Desai, Priyanka

2006-03-01

Emissions of methane (CH4) and carbon dioxide (CO2) from spent mycelia of the mold Penicilium notatum and sludge from the effluent treatment facility (ETPS) of a pharmaceutical industry were estimated twice during a two-week composting before vermicomposting. These wastes are dumped in landfills or sometimes used in agricultural fields and no reports are available on their greenhouse gas producing potentials. The solid wastes contained appreciable organic carbon and nitrogen while very high Fe, Mn and Zn were found in ETPS only. Pure wastes did not support germination of Vigna radiata L. while mixing soil with ETPS and spent mycelia at the ratios of 12:1 and 14:1 led to 80% and 50% germination, respectively. The wastes were mixed with cowdung at the ratios of 1:1, 1:3 and 3:1 for composting. Carbon dioxide emissions were always significantly higher than CH4 emissions from all the treatments due to prevalence of aerobic condition during composting. From some treatments, CH4 emissions increased with time, indicating increasing activity of anaerobic bacteria in the waste mixtures. Methane emissions ranged from 21.6 to 231.7 microg m(-2) day(-1) while CO2 emissions were greater than thousand times at 39.8-894.8 mg m(-2) day(-1). The amount of C emitted as CH4-C and CO2-C from ranged from 0.007% to 0.081% of total C composted. Cowdung emitted highest CH4 followed by spent mycelia and ETPS while ETPS emitted more CO2 than spent mycelia but lesser than cowdung. Global warming potential of emitted CH4 was found to be in the range of 10.6-27.7 mg-CO2-equivalent on a 20-year time horizon. The results suggest that pharmaceutical wastes can be an important source of CH4 and CO2 during composting or any other stockpiling under suitable moisture conditions. The waste mixtures were found not suitable for vermicomposting after two weeks composting and earthworms did not survive long in the mixtures.

Correlation to FVIII:C in Two Thrombin Generation Tests: TGA-CAT and INNOVANCE ETP.

PubMed

Ljungkvist, Marcus; Berndtsson, Maria; Holmström, Margareta; Mikovic, Danijela; Elezovic, Ivo; Antovic, Jovan P; Zetterberg, Eva; Berntorp, Erik

2017-01-01

Several thrombin-generation tests are available, but few have been directly compared. Our primary aim was to investigate the correlation of two thrombin generation tests, thrombin generation assay-calibrated automated thrombogram (TGA-CAT) and INNOVANCE ETP, to factor VIII levels (FVIII:C) in a group of patients with hemophilia A. The secondary aim was to investigate inter-laboratory variation for the TGA-CAT method. Blood samples were taken from 45 patients with mild, moderate and severe hemophilia A. The TGA-CAT method was performed at both centers while the INNOVANCE ETP was only performed at the Stockholm center. Correlation between parameters was evaluated using Spearman's rank correlation test. For determination of the TGA-CAT inter-laboratory variability, Bland-Altman plots were used. The correlation for the INNOVANCE ETP and TGA-CAT methods with FVIII:C in persons with hemophilia (PWH) was r=0.701 and r=0.734 respectively.The correlation between the two methods was r=0.546.When dividing the study material into disease severity groups (mild, moderate and severe) based on FVIII levels, both methods fail to discriminate between them.The variability of the TGA-CAT results performed at the two centers was reduced after normalization; before normalization, 29% of values showed less than ±10% difference while after normalization the number increased to 41%. Both methods correlate in an equal manner to FVIII:C in PWH but show a poor correlation with each other. The level of agreement for the TGA-CAT method was poor though slightly improved after normalization of data. Further improvement of standardization of these methods is warranted.

Genetic Determinants of Thrombin Generation and Their Relation to Venous Thrombosis: Results from the GAIT-2 Project

PubMed Central

Martin-Fernandez, Laura; Ziyatdinov, Andrey; Carrasco, Marina; Millon, Juan Antonio; Martinez-Perez, Angel; Vilalta, Noelia; Brunel, Helena; Font, Montserrat; Hamsten, Anders; Souto, Juan Carlos; Soria, José Manuel

2016-01-01

Background Venous thromboembolism (VTE) is a common disease where known genetic risk factors explain only a small portion of the genetic variance. Then, the analysis of intermediate phenotypes, such as thrombin generation assay, can be used to identify novel genetic risk factors that contribute to VTE. Objectives To investigate the genetic basis of distinct quantitative phenotypes of thrombin generation and its relationship to the risk of VTE. Patients/Methods Lag time, thrombin peak and endogenous thrombin potential (ETP) were measured in the families of the Genetic Analysis of Idiopathic Thrombophilia 2 (GAIT-2) Project. This sample consisted of 935 individuals in 35 extended families selected through a proband with idiopathic thrombophilia. We performed also genome wide association studies (GWAS) with thrombin generation phenotypes. Results The results showed that 67% of the variation in the risk of VTE is attributable to genetic factors. The heritabilities of lag time, thrombin peak and ETP were 49%, 54% and 52%, respectively. More importantly, we demonstrated also the existence of positive genetic correlations between thrombin peak or ETP and the risk of VTE. Moreover, the major genetic determinant of thrombin generation was the F2 gene. However, other suggestive signals were observed. Conclusions The thrombin generation phenotypes are strongly genetically determined. The thrombin peak and ETP are significantly genetically correlated with the risk of VTE. In addition, F2 was identified as a major determinant of thrombin generation. We reported suggestive signals that might increase our knowledge to explain the variability of this important phenotype. Validation and functional studies are required to confirm GWAS results. PMID:26784699

Enhancement of the spring East China precipitation response to tropical sea surface temperature variability

NASA Astrophysics Data System (ADS)

Zhang, Mengqi; Sun, Jianqi

2017-12-01

The boreal spring relationship between variabilities of East China precipitation (ECP) and tropical Ocean sea surface temperature (SST) during the period 1951-2014 is investigated in this study. The results show that the leading mode of the ECP variability exhibits an enhanced response to the anomalous El Niño-Southern Oscillation (ENSO)-like SST after the late 1970s, when the SST underwent a decadal change, with two positive centers over the eastern tropical Pacific (ETP) and tropical Indian Ocean (TIO). To further understand the relative roles of the ETP and TIO SST anomalies (SSTAs) in the variability of ECP after the late 1970s, partial regression and correlation methods are used. It is found that, without the contribution of the TIO, ETP SSTA plays a limited role in the variability of ECP after the late 1970s; comparatively, a significant correlation between TIO SST and ECP is identified during the same period, when the ETP signal is linearly removed. Physical analyses show that, after the late 1970s, the TIO SSTA affects East Asian atmospheric circulation in two ways: by exciting a zonal wave-train pattern over the mid-latitude Eurasian Continent and by inducing anomalous convection over the Maritime Continent. Via these two mechanisms, the TIO SST variability results in an anomalous East Asian trough and vertical motion over East China and consequently leads to anomalous precipitation over the region. The physical processes linking the ECP and TIO SST are confirmed by an atmospheric general circulation model experiment forced with idealized TIO warming.

Effect of brewery wastewater obtained from different phases of treatment plant on seed germination of chickpea (Cicer arietinum), maize (Zea mays), and pigeon pea (Cajanus cajan).

PubMed

Salian, Rupa; Wani, Suhas; Reddy, Ramamohan; Patil, Mukund

2018-03-01

Brewing industry releases large quantities of wastewater after product generation. Brewery wastewater contains organic compounds which are biodegradable in nature. These biodegradable wastes can be recycled and reused and hence considered as suitable products for agriculture. But before using wastewater for agriculture, it is better to evaluate the phytotoxic effects of wastewater on crops. Hence, the main objective of this study is to evaluate the effects of brewery effluent on seed germination and growth parameters of selected crop species like chickpea (Cicer arietinum), maize (Zea mays), and pigeon pea (Cajanus cajan). Study comprised seven types of water treatments-tap water as control, diluted UASBR effluent (50% effluent + 50% distilled water): UASBR50, undiluted UASBR effluent: UASBR100, diluted TC effluent (50% effluent + 50% distilled water): ETP50,TC effluent without dilution: ETP100, 10% diluted reverse osmosis (RO10) reject (10% RO reject + 90% distilled water), and 25% diluted reverse osmosis(RO25) reject (25% RO reject + 75% distilled water) with three replications in completely randomized design. Germination test was performed in petri plates for 5 days. Parameters like germination percentage, germination rate index, seedling length, phytotoxicity index, seed vigor index, and biomass were calculated. All parameters decreased with increase in respective effluent concentration. Among all treatments, RO25 showed highest inhibitory effect on all three crops. Even though undiluted effluent of UASBR and ETP effluent showed positive effect on germination, seedling growth of three crops was promoted to the maximum by UASBR50 and ETP50. Hence, from the study, it was concluded that dilution of brewery effluent can be recommended before using it for irrigational purpose.

Electronic and steric influences of pendant amine groups on the protonation of molybdenum bis (dinitrogen) complexes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Labios, Liezel A.; Heiden, Zachariah M.; Mock, Michael T.

2015-05-04

The synthesis of a series of P EtP NRR' (P EtP NRR' = Et₂PCH₂CH₂P(CH₂NRR')₂, R = H, R' = Ph or 2,4-difluorophenyl; R = R' = Ph or iPr) diphosphine ligands containing mono- and disubstituted pendant amine groups, and the preparation of their corresponding molybdenum bis(dinitrogen) complexes trans-Mo(N₂)₂(PMePh₂)₂(P EtP NRR') is described. In situ IR and multinuclear NMR spectroscopic studies monitoring the stepwise addition of (HOTf) to trans-Mo(N₂)₂(PMePh₂)₂(P EtP NRR') complexes in THF at -40 °C show that the electronic and steric properties of the R and R' groups of the pendant amines influence whether the complexes are protonated atmore » Mo, a pendant amine, a coordinated N2 ligand, or a combination of these sites. For example, complexes containing mono-aryl substituted pendant amines are protonated at Mo and pendant amine to generate mono- and dicationic Mo–H species. Protonation of the complex containing less basic diphenyl-substituted pendant amines exclusively generates a monocationic hydrazido (Mo(NNH₂)) product, indicating preferential protonation of an N₂ ligand. Addition of HOTf to the complex featuring more basic diisopropyl amines primarily produces a monocationic product protonated at a pendant amine site, as well as a trace amount of dicationic Mo(NNH₂) product that contain protonated pendant amines. In addition, trans-Mo(N₂)₂(PMePh₂)₂(depe) (depe = Et₂PCH₂CH₂PEt₂) without a pendant amine was synthesized and treated with HOTf, generating a monocationic Mo(NNH₂) product. Protonolysis experiments conducted on select complexes in the series afforded trace amounts of NH₄⁺. Computational analysis of the series of trans-Mo(N₂)₂(PMePh₂)₂(P EtP NRR') complexes provides further insight into the proton affinity values of the metal center, N₂ ligand, and pendant amine sites to rationalize the differing reactivity profiles. This research was supported as part of the Center for Molecular Electrocatalysis, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences. Computational resources provided by the National Energy Research Scientific Computing Center (NERSC) at Lawrence Berkeley National Laboratory. Pacific Northwest National Laboratory is operated by Battelle for the U.S. Department of Energy.« less

Potential scenarios for broadening stakeholder involvement in the implementing geological disposal technology platform

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martell, Meritxell; Bergmans, Anne

This paper analyses the potential for the involvement of different types of stakeholders in the Implementing Geological Disposal Technology Platform (IGD-TP). This analysis was conducted as part of the InSOTEC project, a three-year (2011- 2014) collaborative research project funded under the 7. Euratom Framework Programme (Grant Agreement nr. 269906). In our analysis, we consider the extent to which the IGDTP's practice as regards to stakeholder involvement matches its discourse, and what potential for improvement exists given its structural organisation as a European Technology Platform (ETPs). Technology Platforms (TPs) can be understood as knowledge networks, deliberately set up to influence (research)more » policy in a specific domain. We therefore use knowledge networks as a conceptual approach and look at the IGD-TP as a complex network which includes actors, knowledge and practices across different countries, focusing on a very specific topic (i.e. implementing geological disposal). We compare the way different stakeholders are involved in the IGD-TP to the practice of other ETPs, and explore how the IGD-TP is viewed by its members and by outsiders to the platform Applying Callon's framework of knowledge co-production (1999) we come to define different degrees of interaction between science, society and policy in view of defining research and development (R and D) priorities [1]. Subsequently we describe how these interactions could be conceptualised and interpreted for the IGD-TP. The current approach of the IGDTP can be mainly understood as classical model involving mainly expert stakeholders and scientists. Where there seems to be a good representation among IGD-TP members of industry, research institutes, and some members of the academic community this is not the case for other types of stakeholders, such as public authorities or civil society. At this stage, the overall approach of the IGD-TP would seem to restrict the scope of stakeholder involvement, as it narrows participation down to uniquely technology experts, hindering socio-technical manifestations. Our analysis nevertheless shows that there is room for engaging with a broader range of stakeholders in the field of radioactive waste management, if this is the intention of the IGD-TP. However, this would require a commitment to developing a common knowledge base including other stakeholders through a process of mutual adjustment and negotiation. (authors)« less

VERAM, for a sustainable and competitive future for EU Raw Materials

NASA Astrophysics Data System (ADS)

Mobili, A.; Tittarelli, F.; Revel, G. M.; Wall, P.

2018-03-01

The project, VERAM “Vision and Roadmap for European Raw Materials”, aims to deliver a mapping of on-going initiatives on non-food, non-energy raw materials (including metals, industrial minerals, aggregates and wood) at European, Member State, and regional levels both from the Research and Innovation (R&I), industry, and policy perspectives. Moreover, based on a comprehensive gap analysis, VERAM will propose a common long term 2050 Vision and Roadmap in coordination and cooperation with all stakeholders across the value chain. For the first time, two European Technology Platforms (ETPs) together with their corresponding European Research Area Networks (ERA-NETs) are joining forces to develop a common roadmap.

Genetic variation in blue whales in the eastern pacific: implication for taxonomy and use of common wintering grounds.

PubMed

Leduc, R G; Archer, F I; Lang, A R; Martien, K K; Hancock-Hanser, B; Torres-Florez, J P; Hucke-Gaete, R; Rosenbaum, H C; van Waerebeek, K; Brownell, R L; Taylor, B L

2017-02-01

Many aspects of blue whale biology are poorly understood. Some of the gaps in our knowledge, such as those regarding their basic taxonomy and seasonal movements, directly affect our ability to monitor and manage blue whale populations. As a step towards filling in some of these gaps, microsatellite and mtDNA sequence analyses were conducted on blue whale samples from the Southern Hemisphere, the eastern tropical Pacific (ETP) and the northeast Pacific. The results indicate that the ETP is differentially used by blue whales from the northern and southern eastern Pacific, with the former showing stronger affinity to the region off Central America known as the Costa Rican Dome, and the latter favouring the waters of Peru and Ecuador. Although the pattern of genetic variation throughout the Southern Hemisphere is compatible with the recently proposed subspecies status of Chilean blue whales, some discrepancies remain between catch lengths and lengths from aerial photography, and not all blue whales in Chilean waters can be assumed to be of this type. Also, the range of the proposed Chilean subspecies, which extends to the Galapagos region of the ETP, at least seasonally, perhaps should include the Costa Rican Dome and the eastern North Pacific as well. © 2016 John Wiley & Sons Ltd.

Spatiotemporal drought variability of the eastern Tibetan Plateau during the last millennium

NASA Astrophysics Data System (ADS)

Deng, Yang; Gou, Xiaohua; Gao, Linlin; Yang, Meixue; Zhang, Fen

2017-09-01

Tibetan Plateau is the headwater region of many major Asian rivers and very susceptive to climate change. Therefore, knowledge about climate and its spatiotemporal variability in this area is very important for ecological conservation, water resource management and social development. The aim of this study was to reconstruct and analyze the hydroclimate variation on eastern Tibetan Plateau (ETP) over many centuries and explore possible forcing factors on regional hydroclimate variability. We used 118 tree-ring chronologies from ETP to reconstruct the gridded May-July Standardized Precipitation Evapotranspiration Index for the ETP over the last millennium. The reconstruction was developed using an ensemble point-by-point reconstruction method, and a searching region method was used to locate the candidate tree-ring chronologies. The reconstructions have nicely captured the spatial and temporal features of the regional drought variation. The drought variations in south and north of 32.5°N are notably different, which may be related to the divergence influence of North Atlantic Oscillation on the climate systems in the south and north, as well as differences in local climate. Spectral analysis and series comparison suggest that the drought variation in the northeastern Tibetan Plateau has been possibly influenced by solar activity on centurial and longer time scale.

Dynamics of microbiological parameters, enzymatic activities and worm biomass production during vermicomposting of effluent treatment plant sludge of bakery industry.

PubMed

Yadav, Anoop; Suthar, S; Garg, V K

2015-10-01

This paper reports the changes in microbial parameters and enzymatic activities during vermicomposting of effluent treatment plant sludge (ETPS) of bakery industry spiked with cow dung (CD) by Eisenia fetida. Six vermibins containing different ratios of ETPS and CD were maintained under controlled laboratory conditions for 15 weeks. Total bacterial and total fungal count increased upto 7th week and declined afterward in all the bins. Maximum bacterial and fungal count was 31.6 CFU × 10(6) g(-1) and 31 CFU × 10(4) g(-1) in 7th week. Maximum dehydrogenase activity was 1921 μg TPF g(-1) h(-1) in 9th week in 100 % CD containing vermibin, whereas maximum urease activity was 1208 μg NH4 (-)N g(-1) h(-1) in 3rd week in 100 % CD containing vermibin. The enzyme activity and microbial counts were lesser in ETPS containing vermibins than control (100 % CD). The growth and fecundity of the worms in different vermibins were also investigated. The results showed that initially biomass and fecundity of the worms increased but decreased at the later stages due to non-availability of the palatable feed. This showed that quality and palatability of food directly affect biological parameters of the system.

Easterly denitrification signal and nitrogen fixation feedback documented in the western Pacific sediments

NASA Astrophysics Data System (ADS)

Jia, Guodong; Li, Zhiyang

2011-12-01

A sedimentary δ15N record in the equatorial western Pacific (WP) shows glacial-interglacial variability from 6.2 to 11.2‰ during the last two climatic cycles, similar to the denitrification record in the eastern tropical Pacific (ETP). Contrastively, a record in the South China Sea (SCS) exhibits less changes from 4.4 to 6.4‰ and is quite alike previously published results in marginal seas in the WP. By ruling out several possible causes for the δ15N variability, the δ15N record in the equatorial WP is interpreted as the source nitrate δ15N signals advected from the ETP. Comparison of several δ15N records for the last 25 ka distributed in the WP brings out a pattern of northward decrease in δ15N values and variability from the equator to off Mindano and then to marginal seas, supposed to be caused by the northward increase of local N2 fixation. Therefore, the less glacial-interglacial changes in some δ15N records in the WP could imply that the glacial decrease in subsurface δ15N due to less denitrification in source waters from the ETP would have been isotopically compensated by a synchronous decrease in local N2 fixation.

In-Plant Corrosion Study of Steels in Distillery Effluent Treatment Plant

NASA Astrophysics Data System (ADS)

Ram, Chhotu; Sharma, Chhaya; Singh, A. K.

2015-05-01

The present study deals with corrosion and performance of steels observed in an effluent treatment plant (ETP) of a distillery. For this purpose, the metal coupons were exposed in primary (untreated effluent) and secondary tank (anaerobic treatment effluent) of the ETP. The extent of attack has been correlated with the composition of the effluent with the help of laboratory immersion and electrochemical tests. Untreated distillery effluent found to be more corrosive than the anaerobic-treated effluents and is assigned due to chloride, phosphate, calcium, nitrate, and nitrite ions, which enhances corrosivity at acidic pH. Mild steel showed highest uniform and localized corrosion followed by stainless steels 304L and 316L and lowest in case of duplex 2205.

Assessment of the nutrient removal effectiveness of floating treatment wetlands applied to urban retention ponds.

PubMed

Wang, Chih-Yu; Sample, David J

2014-05-01

The application of floating treatment wetlands (FTWs) in point and non-point source pollution control has received much attention recently. Although the potential of this emerging technology is supported by various studies, quantifying FTW performance in urban retention ponds remains elusive due to significant research gaps. Actual urban retention pond water was utilized in this mesocosm study to evaluate phosphorus and nitrogen removal efficiency of FTWs. Multiple treatments were used to investigate the contribution of each component in the FTW system with a seven-day retention time. The four treatments included a control, floating mat, pickerelweed (Pontederia cordata L.), and softstem bulrush (Schoenoplectus tabernaemontani). The water samples collected on Day 0 (initial) and 7 were analyzed for total phosphorus (TP), total particulate phosphorus, orthophosphate, total nitrogen (TN), organic nitrogen, ammonia nitrogen, nitrate-nitrite nitrogen, and chlorophyll-a. Statistical tests were used to evaluate the differences between the four treatments. The effects of temperature on TP and TN removal rates of the FTWs were described by the modified Arrhenius equation. Our results indicated that all three FTW designs, planted and unplanted floating mats, could significantly improve phosphorus and nitrogen removal efficiency (%, E-TP and E-TN) compared to the control treatment during the growing season, i.e., May through August. The E-TP and E-TN was enhanced by 8.2% and 18.2% in the FTW treatments planted with the pickerelweed and softstem bulrush, respectively. Organic matter decomposition was likely to be the primary contributor of nutrient removal by FTWs in urban retention ponds. Such a mechanism is fostered by microbes within the attached biofilms on the floating mats and plant root surfaces. Among the results of the four treatments, the FTWs planted with pickerelweed had the highest E-TP, and behaved similarly with the other two FTW treatments for nitrogen removal during the growth period. The temperature effects described by the modified Arrhenius equation revealed that pickerelweed is sensitive to temperature and provides considerable phosphorus removal when water temperature is greater than 25 °C. However, the nutrient removal effectiveness of this plant species may be negligible for water temperatures below 15 °C. The study also assessed potential effects of shading from the FTW mats on water temperature, DO, pH, and attached-to-substrate periphyton/vegetation. Copyright © 2014 Elsevier Ltd. All rights reserved.

Structure and phylogeography of two tropical predators, spinner (Stenella longirostris) and pantropical spotted (S. attenuata) dolphins, from SNP data

PubMed Central

Morin, Phillip A.

2018-01-01

Little is known about global patterns of genetic connectivity in pelagic dolphins, including how circumtropical pelagic dolphins spread globally following the rapid and recent radiation of the subfamily delphininae. In this study, we tested phylogeographic hypotheses for two circumtropical species, the spinner dolphin (Stenella longirostris) and the pantropical spotted dolphin (Stenella attenuata), using more than 3000 nuclear DNA single nucleotide polymorphisms (SNPs) in each species. Analyses for population structure indicated significant genetic differentiation between almost all subspecies and populations in both species. Bayesian phylogeographic analyses of spinner dolphins showed deep divergence between Indo-Pacific, Atlantic and eastern tropical Pacific Ocean (ETP) lineages. Despite high morphological variation, our results show very close relationships between endemic ETP spinner subspecies in relation to global diversity. The dwarf spinner dolphin is a monophyletic subspecies nested within a major clade of pantropical spinner dolphins from the Indian and western Pacific Ocean populations. Population-level division among the dwarf spinner dolphins was detected—with the northern Australia population being very different from that in Indonesia. In contrast to spinner dolphins, the major boundary for spotted dolphins is between offshore and coastal habitats in the ETP, supporting the current subspecies-level taxonomy. Comparing these species underscores the different scale at which population structure can arise, even in species that are similar in habitat (i.e. pelagic) and distribution. PMID:29765639

Characterization Results for the March 2016 H-Tank Farm 2H Evaporator Overhead Samples

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nicholson, J. C.

This report contains the radioanalytical results of the 2H evaporator overhead sample received at SRNL on March 16, 2016. Specifically, concentrations of 137Cs, 90Sr, and 129I are reported and compared to the corresponding Waste Acceptance Criteria (WAC) limits of the Effluent Treatment Project (ETP) Waste Water Collection Tank (WWCT) (rev. 6). All of the radionuclide concentrations in the sample were found to be in compliance with the ETP WAC limits. Revision 1 of this document corrects the cumulative beta count initially reported for 90Sr content with the sole 90Sr count obtained after recharacterization of the sample. The initial data wasmore » found to be a cumulative beta count rather than the 90Sr count requested.« less

Implementation Options for the PROPEL Electrodynamic Tether Demonstration Mission

NASA Technical Reports Server (NTRS)

Bilen, Sven G.; Johnson, C. Les; Gilchrist, Brian E.; Hoyt, Robert P.; Elder, Craig H.; Fuhrhop, Keith P.; Scadera, Michael; Stone, Nobie

2014-01-01

The PROPEL ("Propulsion using Electrodynamics") flight demonstration mission concept will demonstrate the use of an electrodynamic tether (EDT) for generating thrust, which will allow the propulsion system to overcome the limitations of the rocket equation. The mission concept has been developed by a team of government, industry, and academia partners led by NASA Marshall Space Flight Center (MSFC). PROPEL is being designed for versatility of the EDT system with multiple end users in mind and to be flexible with respect to platform. Previously, we reported on a comprehensive mission design for PROPEL with a mission duration of six months or longer with multiple mission goals including demonstration of significant boost, deboost, inclination change, and drag make-up activities. To explore a range of possible configurations, primarily driven by cost considerations, other mission concept designs have been pursued. In partnership with the NASA's Office of Chief Technologist (OCT) Game Changing Program, NASA MSFC Leadership, and the MSFC Advanced Concepts Office, a mission concept design was developed for a near-term EDT propulsion flight validation mission. The Electrodynamic Tether Propulsion Study (ETPS) defined an EDT propulsion system capable of very large delta-V for use on future missions developed by NASA, DoD, and commercial customers. To demonstrate the feasibility of an ETPS, the study focused on a space demonstration mission concept design with configuration of a pair of tethered satellite busses, one of which is the Japanese H-II Transfer Vehicle (HTV). The HTV would fly its standard ISS resupply mission. When resupply mission is complete, the ISS reconfigures and releases the HTV to perform the EDT experiment at safe orbital altitudes below the ISS. Though the focus of this particular mission concept design addresses a scenario involving the HTV or a similar vehicle, the propulsion system's capability is relevant to a number of applications, as noted above. The ETPS builds on prior work on long-life, failure-resistant, conducting tethers and includes an instrument suite with demonstrated heritage capable of performing necessary diagnostics to measure performance against predictions for a given system size (to be determined) and boost rate. Mission designs in other configurations and launch vehicle options are being developed such that the system can be demonstration should a flight opportunity be identified. We will report on past and ongoing implementation options for PROPEL.

ETP-46321, a dual p110α/δ class IA phosphoinositide 3-kinase inhibitor modulates T lymphocyte activation and collagen-induced arthritis.

PubMed

Aragoneses-Fenoll, L; Montes-Casado, M; Ojeda, G; Acosta, Y Y; Herranz, J; Martínez, S; Blanco-Aparicio, C; Criado, G; Pastor, J; Dianzani, U; Portolés, P; Rojo, J M

2016-04-15

Class IA phosphoinositide 3-kinases (PI3Ks) are essential to function of normal and tumor cells, and to modulate immune responses. T lymphocytes express high levels of p110α and p110δ class IA PI3K. Whereas the functioning of PI3K p110δ in immune and autoimmune reactions is well established, the role of p110α is less well understood. Here, a novel dual p110α/δ inhibitor (ETP-46321) and highly specific p110α (A66) or p110δ (IC87114) inhibitors have been compared concerning T cell activation in vitro, as well as the effect on responses to protein antigen and collagen-induced arthritis in vivo. In vitro activation of naive CD4(+) T lymphocytes by anti-CD3 and anti-CD28 was inhibited more effectively by the p110δ inhibitor than by the p110α inhibitor as measured by cytokine secretion (IL-2, IL-10, and IFN-γ), T-bet expression and NFAT activation. In activated CD4(+) T cells re-stimulated through CD3 and ICOS, IC87114 inhibited Akt and Erk activation, and the secretion of IL-2, IL-4, IL-17A, and IFN-γ better than A66. The p110α/δ inhibitor ETP-46321, or p110α plus p110δ inhibitors also inhibited IL-21 secretion by differentiated CD4(+) T follicular (Tfh) or IL-17-producing (Th17) helper cells. In vivo, therapeutic administration of ETP-46321 significantly inhibited responses to protein antigen as well as collagen-induced arthritis, as measured by antigen-specific antibody responses, secretion of IL-10, IL-17A or IFN-γ, or clinical symptoms. Hence, p110α as well as p110δ Class IA PI3Ks are important to immune regulation; inhibition of both subunits may be an effective therapeutic approach in inflammatory autoimmune diseases like rheumatoid arthritis. Copyright © 2016 Elsevier Inc. All rights reserved.

Trophic ecology of sea urchins in coral-rocky reef systems, Ecuador

PubMed Central

Loor-Andrade, Peggy; Rodríguez-Barreras, Ruber; Cortés, Jorge

2016-01-01

Sea urchins are important grazers and influence reef development in the Eastern Tropical Pacific (ETP). Diadema mexicanum and Eucidaris thouarsii are the most important sea urchins on the Ecuadorian coastal reefs. This study provided a trophic scenario for these two species of echinoids in the coral-rocky reef bottoms of the Ecuadorian coast, using stable isotopes. We evaluated the relative proportion of algal resources assimilated, and trophic niche of the two sea urchins in the most southern coral-rocky reefs of the ETP in two sites with different disturbance level. Bayesian models were used to estimate the contribution of algal sources, niche breadth, and trophic overlap between the two species. The sea urchins behaved as opportunistic feeders, although they showed differential resource assimilation. Eucidaris thouarsii is the dominant species in disturbed environments; likewise, their niche amplitude was broader than that of D. mexicanum when conditions were not optimal. However, there was no niche overlap between the species. The Stable Isotope Analysis in R (SIAR) indicated that both sea urchins shared limiting resources in the disturbed area, mainly Dictyota spp. (contributions of up to 85% for D. mexicanum and up to 75% for E. thouarsii). The Stable Isotope Bayesian Ellipses in R (SIBER) analysis results indicated less interspecific competition in the undisturbed site. Our results suggested a trophic niche partitioning between sympatric sea urchin species in coastal areas of the ETP, but the limitation of resources could lead to trophic overlap and stronger habitat degradation. PMID:26839748

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Electron temperature and density probe for small aeronomy satellites

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oyama, K.-I.; Institute of Space and Plasma Sciences, National Cheng Kung University, Tainan, Taiwan; International Center for Space Weather Study and education, Kyushu University, Fukuoka

2015-08-15

A compact and low power consumption instrument for measuring the electron density and temperature in the ionosphere has been developed by modifying the previously developed Electron Temperature Probe (ETP). A circuit block which controls frequency of the sinusoidal signal is added to the ETP so that the instrument can measure both T{sub e} in low frequency mode and N{sub e} in high frequency mode from the floating potential shift of the electrode. The floating potential shift shows a minimum at the upper hybrid resonance frequency (f{sub UHR}). The instrument which is named “TeNeP” can be used for tiny satellites whichmore » do not have enough conductive surface area for conventional DC Langmuir probe measurements. The instrument also eliminates the serious problems associated with the contamination of satellite surface as well as the sensor electrode.« less

ETP-0492, Measured Residual Stresses in CYL S/N 53 Fretted Area

NASA Technical Reports Server (NTRS)

Webster, Ronald L.

1998-01-01

This test report presents the results of a residual stress survey of the inner clevis leg of lightweight cylinder SIN 053 as described by ETP-0492. The intent of this testing was to evaluate the residual stresses that occur in and around the inner clevis leg at the capture feature contact zone during a normal flight cycle. Lightweight case cylinder segment IU50717, S/N L053 from Flight STS-27 exhibited fretting around the contact zone of the inner clevis leg and the capture feature of the field joint. Post flight inspection revealed several large fitting pits on the inside of the inner clevis leg. This cylinder was assigned for both residual stress and metallurgical evaluation. This report is concerned only with the residual so= evaluations. The effects of glass bead cleaning and fi=ing were evaluated using the x-ray diffraction method.

Application of enthalpy model for floating zone silicon crystal growth

NASA Astrophysics Data System (ADS)

Krauze, A.; Bergfelds, K.; Virbulis, J.

2017-09-01

A 2D simplified crystal growth model based on the enthalpy method and coupled with a low-frequency harmonic electromagnetic model is developed to simulate the silicon crystal growth near the external triple point (ETP) and crystal melting on the open melting front of a polycrystalline feed rod in FZ crystal growth systems. Simulations of the crystal growth near the ETP show significant influence of the inhomogeneities of the EM power distribution on the crystal growth rate for a 4 in floating zone (FZ) system. The generated growth rate fluctuations are shown to be larger in the system with higher crystal pull rate. Simulations of crystal melting on the open melting front of the polycrystalline rod show the development of melt-filled grooves at the open melting front surface. The distance between the grooves is shown to grow with the increase of the skin-layer depth in the solid material.

RNA sequencing of chorionic villi from recurrent pregnancy loss patients reveals impaired function of basic nuclear and cellular machinery

PubMed Central

Sõber, Siim; Rull, Kristiina; Reiman, Mario; Ilisson, Piret; Mattila, Pirkko; Laan, Maris

2016-01-01

Recurrent pregnancy loss (RPL) concerns ~3% of couples aiming at childbirth. In the current study, transcriptomes and miRNomes of 1st trimester placental chorionic villi were analysed for 2 RPL cases (≥6 miscarriages) and normal, but electively terminated pregnancies (ETP; n = 8). Sequencing was performed on Illumina HiSeq 2000 platform. Differential expression analyses detected 51 (27%) transcripts with increased and 138 (73%) with decreased expression in RPL compared to ETP (DESeq: FDR P < 0.1 and DESeq2: <0.05). RPL samples had substantially decreased transcript levels of histones, regulatory RNAs and genes involved in telomere, spliceosome, ribosomal, mitochondrial and intra-cellular signalling functions. Downregulated expression of HIST1H1B and HIST1H4A (Wilcoxon test, fc≤0.372, P≤9.37 × 10−4) was validated in an extended sample by quantitative PCR (RPL, n = 14; ETP, n = 24). Several upregulated genes are linked to placental function and pregnancy complications: ATF4, C3, PHLDA2, GPX4, ICAM1, SLC16A2. Analysis of the miRNA-Seq dataset identified no large disturbances in RPL samples. Notably, nearly 2/3 of differentially expressed genes have binding sites for E2F transcription factors, coordinating mammalian endocycle and placental development. For a conceptus destined to miscarriage, the E2F TF-family represents a potential key coordinator in reprogramming the placental genome towards gradually stopping the maintenance of basic nuclear and cellular functions. PMID:27929073

Effects of recombinant human prothrombin on thrombin generation in plasma from patients with hemophilia A and B.

PubMed

Hansson, K M; Gustafsson, D; Skärby, T; Frison, L; Berntorp, E

2015-07-01

The present study was carried out to investigate the impact of FII levels, and their increase, on the hemostatic potential in plasma from hemophilia A and B patients with and without inhibitors. Recombinant human factor (F) II (rhFII) was added ex vivo to plasma from 68 patients with hemophilia A and B, with or without inhibitors. The hemostatic potential as measured by thrombin generation (calibrated automated thrombogram [CAT]) was focused on the endogenous thrombin potential (ETP) as it has been shown to correlate with the clinical phenotype of bleeding in hemophilia patients and has also been used to guide bypassing therapy in hemophilia patients with inhibitors before elective surgery. The factor eight inhibitor bypassing agent (FEIBA(®) ) was used as a reference to the clinical situation. The study shows that rhFII concentration-dependently increased ETP by a similar magnitude in hemophilia A and B, both with and without inhibitors. Compared with FEIBA, rhFII showed a shallower concentration-response curve. In both types of hemophilia 100 mg L(-1) of rhFII roughly doubled the ETP. A corresponding response was obtained by 0.5 U mL(-1) of FEIBA. These data support the theory that FII is one of the major components responsible for the efficacy of FEIBA. The data also indicate that rhFII may be useful, alone or in combination with other coagulation factors, in some of the conditions for which FEIBA is used today, although more data are needed to substantiate this. © 2015 International Society on Thrombosis and Haemostasis.

The evaluation of epoxy thermoplastic pavement marking material in Virginia : the application : interim report.

DOT National Transportation Integrated Search

1983-01-01

Epoxy Thermoplastic (ETP) is a recently developed epoxy-resin-based thermoplastic pavement marking material being promoted by the Federal Highway Administration as a possible substitute for conventional traffic paints and thermoplastics. Its reported...

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Biogenetically-Inspired Total Synthesis of Epidithiodiketopiperazines and Related Alkaloids

PubMed Central

2015-01-01

Conspectus Natural products chemistry has historically been the prime arena for the discovery of new chemical transformations and the fountain of insights into key biological processes. It remains a fervent incubator of progress in the fields of chemistry and biology and an exchange mediating the flow of ideas between these allied fields of science. It is with this ethos that our group has taken an interest in and pursued the synthesis of a complex family of natural products termed the dimeric epipolythiodiketopiperazine (ETP) alkaloids. We present here an Account of the highly complex target molecules to which we pegged our ambitions, our systematic and relentless efforts toward those goals, the chemistry we developed in their pursuit, and the insight we have gained for their translational potential as potent anticancer molecules. The dimeric ETP alkaloids are fungal metabolites that feature a highly complex molecular architecture comprising a densely functionalized core structure with many stereogenic centers, six of which are fully substituted, and a pair of vicinal quaternary carbon stereocenters, decorated on polycyclic architectures in addition to the unique ETP motif that has been recognized as acid-, base-, and redox-sensitive. A cyclo-dipeptide consisting of an essential tryptophan residue and a highly variable ancillary amino acid lies at the core of these structures; investigation of the transformations that take this simplistic core to the complex alkaloids lies at the heart of our research program. The dimeric epidithiodiketopiperazine alkaloids have largely resisted synthesis on account of their complexity since the 1970s when the founding members of this class, chaetocin A (HauserD. et al. Helv. Chim. Acta1970, 53, 10615448218) and verticillin A (KatagiriK. et al. J. Antibiot.1970, 23, 4205465723), were first isolated. This was despite their potent cytotoxic and bacteriostatic activities, which were well appreciated at the time of their discovery. In the past decade, an increasing number of studies have uncovered powerful new biological processes that these molecules can uniquely effect, such as the inhibition of histone methyltransferases by chaetocin A (GreinerD. et al. Nat. Chem. Biol.2005, 1, 14316408017). In fact, the complete collection of hexahydropyrroloindoline alkaloids features a diverse range of potent biological properties including cytotoxic, antitumor, antileukemic, antiviral, antibiotic, and antinematodal activities (JiangC.-S.; GuoY.-W.Mini-Rev. Med. Chem.2011, 11, 72821651467). This mélange of activities is reflective of their structural diversity. Under the precepts of retrobiosynthetic analysis, we have accomplished the syntheses of more than a dozen natural products, including members of the bionectin, calycanthaceous, chaetocin, gliocladin, naseseazine, and verticillin alkaloids. More importantly, these molecules have acted as venerable venues for the development of new strategies to address structural challenges including, but not limited to, C3–C3′ vicinal quaternary centers, heterodimeric linkages, C3–Csp2 linkages, diketopiperazine oxidation, stereoselective thiolation, homologue-specific polysulfidation, and C12-hydroxyl incorporation. Synthesis of these natural products has resulted in the structural confirmation, and sometimes revision such as the case of (+)-naseseazines A and B, as well as access to many plausible biogenetically relevant intermediates and new synthetic ETP derivatives. Furthermore, our studies have paved the way for the formulation of a comprehensive SAR profile and the identification of lead compounds with in vitro subnanomolar IC50’s against a broad range of cancer types. PMID:25843276

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A Phase 3, Randomized, Double-Blind, Multicenter Study to Evaluate the Safety and Efficacy of Intravenous Iclaprim Vs Vancomycin for the Treatment of Acute Bacterial Skin and Skin Structure Infections Suspected or Confirmed to be Due to Gram-Positive Pathogens: REVIVE-1.

PubMed

Huang, David B; O'Riordan, William; Overcash, J Scott; Heller, Barry; Amin, Faisal; File, Thomas M; Wilcox, Mark H; Torres, Antoni; Dryden, Matthew; Holland, Thomas L; McLeroth, Patrick; Shukla, Rajesh; Corey, G Ralph

2018-04-03

Our objective in this study was to demonstrate the safety and efficacy of iclaprim compared with vancomycin for the treatment of patients with acute bacterial skin and skin structure infections (ABSSSIs). REVIVE-1 was a phase 3, 600-patient, double-blinded, randomized (1:1), active-controlled trial among patients with ABSSSI that compared the safety and efficacy of iclaprim 80 mg fixed dose with vancomycin 15 mg/kg, both administered intravenously every 12 hours for 5-14 days. The primary endpoint of this study was a ≥20% reduction in lesion size (early clinical response [ECR]) compared with baseline among patients randomized to iclaprim or vancomycin at the early time point (ETP), 48 to 72 hours after the start of administration of study drug in the intent-to-treat population. ECR among patients who received iclaprim and vancomycin at the ETP was 80.9% (241 of 298) of patients receiving iclaprim compared with 81.0% (243 of 300) of those receiving vancomycin (treatment difference, -0.13%; 95% confidence interval, -6.42%-6.17%). Iclaprim was well tolerated in the study, with most adverse events categorized as mild. Iclaprim achieved noninferiority (10% margin) at ETP compared with vancomycin and was well tolerated in this phase 3 clinical trial for the treatment of ABSSSI. Based on these results, iclaprim appears to be an efficacious and safe treatment for ABSSSI suspected or confirmed to be due to gram-positive pathogens. NCT02600611.

The impact of later trading hours for Australian public houses (hotels) on levels of violence.

PubMed

Chikritzhs, Tanya; Stockwell, Tim

2002-09-01

To examine the impact of later trading hours for licensed hotels (Australian public houses are usually known as "hotels") in Perth, Western Australia, on levels of violent assault on or near these premises. Data on assault offenses reported to police between July 1, 1991, and June 30, 1997, were examined to identify those offenses that occurred on or close to hotels. During this period, 45 (24%) of the 188 hotels meeting study criteria were granted an extended trading permit for 1AM closing ("ETP hotels"), whereas the rest continued to close at midnight ("non-ETP hotels"). A time-series analysis employing linear regression was used to test whether there was a relationship between the introduction of extended trading and monthly rates of assaults associated with ETP hotels, while controlling for the general trend in assault rates among normally trading hotels. Possible confounders and other variables of interest (e.g., levels of alcohol purchases) were also examined. After controlling for the general trend in assaults occurring throughout Perth hotels, there was a significant increase in monthly assault rates for hotels with late trading following the introduction of extended trading permits. This relationship was largely accounted for by higher volumes of high alcohol content beer, wine and distilled spirits purchased by late trading hotels. Late trading was associated with both increased violence in and around Perth hotels and increased levels of alcohol consumption during the study period. It is suggested that greater numbers of patrons and increased levels of intoxication contributed to the observed increase in violence and that systematic planning and evaluation of late trading licenses is required.

Calculation of evapotranspiration: Recursive and explicit methods

USDA-ARS?s Scientific Manuscript database

Crop yield is proportional to crop evapotranspiration (ETc) and it is important to calculate ETc correctly. Methods to calculate ETc have combined empirical and theoretical approaches. The combination method was used to calculate potential ETp. It is a combination method because it combined the ener...

El Niño and coral larval dispersal across the eastern Pacific marine barrier

NASA Astrophysics Data System (ADS)

Wood, S.; Baums, I. B.; Paris, C. B.; Ridgwell, A.; Kessler, W. S.; Hendy, E. J.

2016-08-01

More than 5,000 km separates the frequently disturbed coral reefs of the Eastern Tropical Pacific (ETP) from western sources of population replenishment. It has been hypothesized that El Niño events facilitate eastward dispersal across this East Pacific Barrier (EPB). Here we present a biophysical coral larval dispersal model driven by 14.5 years of high-resolution surface ocean current data including the extreme 1997-1998 El Niño. We find no eastward cross-EPB connections over this period, which implies that ETP coral populations decimated by the 1998 bleaching event can only have recovered from eastern Pacific sources, in congruence with genetic data. Instead, rare connections between eastern and central Pacific reefs are simulated in a westward direction. Significant complexity and variability in the surface flows transporting larvae mean that generalized upper-ocean circulation patterns are poor descriptors of inter-regional connectivity, complicating the assessment of how climate change will impact coral gene flow Pacific wide.

El Niño and coral larval dispersal across the eastern Pacific marine barrier

PubMed Central

Wood, S.; Baums, I. B.; Paris, C. B.; Ridgwell, A.; Kessler, W. S.; Hendy, E. J.

2016-01-01

More than 5,000 km separates the frequently disturbed coral reefs of the Eastern Tropical Pacific (ETP) from western sources of population replenishment. It has been hypothesized that El Niño events facilitate eastward dispersal across this East Pacific Barrier (EPB). Here we present a biophysical coral larval dispersal model driven by 14.5 years of high-resolution surface ocean current data including the extreme 1997–1998 El Niño. We find no eastward cross-EPB connections over this period, which implies that ETP coral populations decimated by the 1998 bleaching event can only have recovered from eastern Pacific sources, in congruence with genetic data. Instead, rare connections between eastern and central Pacific reefs are simulated in a westward direction. Significant complexity and variability in the surface flows transporting larvae mean that generalized upper-ocean circulation patterns are poor descriptors of inter-regional connectivity, complicating the assessment of how climate change will impact coral gene flow Pacific wide. PMID:27550393

Biosynthetic Pathway for the Epipolythiodioxopiperazine Acetylaranotin in Aspergillus terreus Revealed by Genome-based Deletion Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guo, Chun-Jun; Yeh, Hsu-Hua; Chiang, Yi Ming

2013-04-15

Abstract Epipolythiodioxopiperazines (ETPs) are a class of fungal secondary metabolites derived from cyclic peptides. Acetylaranotin belongs to one structural subgroup of ETPs characterized by the presence of a seven-membered dihydrooxepine ring. Defining the genes involved in acetylaranotin biosynthesis should provide a means to increase production of these compounds and facilitate the engineering of second-generation molecules. The filamentous fungus Aspergillus terreus produces acetylaranotin and related natural products. Using targeted gene deletions, we have identified a cluster of 9 genes including one nonribosomal peptide synthase gene, ataP, that is required for acetylaranotin biosynthesis. Chemical analysis of the wild type and mutant strainsmore » enabled us to isolate seventeen natural products that are either intermediates in the normal biosynthetic pathway or shunt products that are produced when the pathway is interrupted through mutation. Nine of the compounds identified in this study are novel natural products. Our data allow us to propose a complete biosynthetic pathway for acetylaranotin and related natural products.« less

Progress of teaching and learning of nuclear engineering courses at College of Engineering, Universiti Tenaga Nasional (UNITEN)

NASA Astrophysics Data System (ADS)

Hamid, Nasri A.; Mohamed, Abdul Aziz; Yusoff, Mohd. Zamri

2015-04-01

Developing human capital in nuclear with required nuclear background and professional qualifications is necessary to support the implementation of nuclear power projects in the near future. Sufficient educational and training skills are required to ensure that the human resources needed by the nuclear power industry meets its high standard. The Government of Malaysia has made the decision to include nuclear as one of the electricity generation option for the country, post 2020 in order to cater for the increasing energy demands of the country as well as to reduce CO2 emission. The commitment by the government has been made clearer with the inclusion of the development of first NPP by 2021 in the Economic Transformation Program (ETP) which was launched by the government in October 2010. The In tandem with the government initiative to promote nuclear energy, Center for Nuclear Energy, College of Engineering, Universiti Tenaga Nasional (UNITEN) is taking the responsibility in developing human capital in the area of nuclear power and technology. In the beginning, the College of Engineering has offered the Introduction to Nuclear Technology course as a technical elective course for all undergraduate engineering students. Gradually, other nuclear technical elective courses are offered such as Nuclear Policy, Security and Safeguards, Introduction to Nuclear Engineering, Radiation Detection and Nuclear Instrumentation, Introduction to Reactor Physics, Radiation Safety and Waste Management, and Nuclear Thermal-hydraulics. In addition, another course Advancement in Nuclear Energy is offered as one of the postgraduate elective courses. To enhance the capability of teaching staffs in nuclear areas at UNITEN, several junior lecturers are sent to pursue their postgraduate studies in the Republic of Korea, United States and the United Kingdom, while the others are participating in short courses and workshops in nuclear that are conducted locally and abroad. This paper describes the progress of teaching and learning in nuclear engineering and technology at UNITEN that include curriculum development, students' enrolment and performance, and teaching staff's human resource development.

Update of incidence and antimicrobial susceptibility trends of Escherichia coli and Klebsiella pneumoniae isolates from Chinese intra-abdominal infection patients.

PubMed

Zhang, Hui; Yang, Qiwen; Liao, Kang; Ni, Yuxing; Yu, Yunsong; Hu, Bijie; Sun, Ziyong; Huang, Wenxiang; Wang, Yong; Wu, Anhua; Feng, Xianju; Luo, Yanping; Chu, Yunzhuo; Chen, Shulan; Cao, Bin; Su, Jianrong; Duan, Qiong; Zhang, Shufang; Shao, Haifeng; Kong, Haishen; Gui, Bingdong; Hu, Zhidong; Badal, Robert; Xu, Yingchun

2017-12-18

To evaluate in vitro susceptibilities of aerobic and facultative Gram-negative bacterial (GNB) isolates from intra-abdominal infections (IAIs) to 12 selected antimicrobials in Chinese hospitals from 2012 to 2014. Hospital acquired (HA) and community acquired (CA) IAIs were collected from 21 centers in 16 Chinese cities. Extended spectrum beta-lactamase (ESBL) status and antimicrobial susceptibilities were determined at a central laboratory using CLSI broth microdilution and interpretive standards. From all isolated strains the Enterobacteriaceae (81.1%) Escherichia coli accounted for 45.4% and Klebsiella pneumoniae for 20.1%, followed by Enterobacter cloacae (5.2%), Proteus mirabilis (2.1%), Citrobacter freundii (1.8%), Enterobacter aerogenes (1.8%), Klebsiella oxytoca (1.4%), Morganella morganii (1.2%), Serratia marcescens (0.7%), Citrobacter koseri (0.3%), Proteus vulgaris (0.3%) and others (1.0%). Non- Enterobacteriaceae (18.9%) included Pseudomonas aeruginosa (9.8%), Acinetobacter baumannii (6.7%), Stenotrophomonas maltophilia (0.9%), Aeromonas hydrophila (0.4%) and others (1.1%). ESBL-screen positive Escherichia coli isolates (ESBL+) showed a decreasing trend from 67.5% in 2012 to 58.9% in 2014 of all Escherichia coli isolates and the percentage of ESBL+ Klebsiella pneumoniae isolates also decreased from 2012 through 2014 (40.4% to 26.6%), which was due to reduced percentages of ESBL+ isolates in HA IAIs for both bacteria. The overall susceptibilities of all 5160 IAI isolates were 87.53% to amikacin (AMK), 78.12% to piperacillin-tazobactam (TZP) 81.41% to imipenem (IMP) and 73.12% to ertapenem (ETP). The susceptibility of ESBL-screen positive Escherichia coli strains was 96.77%-98.8% to IPM, 91.26%-93.16% to ETP, 89.48%-92.75% to AMK and 84.86%-89.34% to TZP, while ESBL-screen positive Klebsiella pneumoniae strains were 70.56%-80.15% susceptible to ETP, 80.0%-87.5% to IPM, 83.82%-87.06% to AMK and 63.53%-68.38% to TZP within the three year study. Susceptibilities to all cephalosporins and fluoroquinolones were less than 50% beside 66.5% and 56.07% to cefoxitin (FOX) for ESBL+ Escherichia coli and Klebsiella pneumoniae strains respectively. The total ESBL+ rates decreased in Escherichia coli and Klebsiella pneumoniae IAI isolates due to fewer prevalence in HA infections. IPM, ETP and AMK were the most effective antimicrobials against ESBL+ Escherichia coli and Klebsiella pneumoniae IAI isolates in 2012-2014 and a change of fluoroquinolone regimens for Chinese IAIs is recommended.

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... the efficiency and cost-effectiveness of trading on the Exchange. Amended Rebate for Double Play... Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule... to adjust the volume thresholds that must be met before an ETP Holder can be eligible to pay the...

77 FR 1545 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-10

... Equities Rule 7400 Series, the Order Audit Trail System (``OATS'') Rules, for Equity Trading Permit (``ETP... Change Extending the Implementation Date of the NYSE Arca Equities Rule 7400 Series, the Order Audit Trail System Rules, for Equity Trading Permit Holders That Are Not Financial Industry Regulatory...

English for Tourism and Hospitality Purposes (ETP)

ERIC Educational Resources Information Center

Zahedpisheh, Nahid; Abu Bakar, Zulqarnain B.; Saffari, Narges

2017-01-01

The quick development of the tourism and hospitality industry can straightly influence the English language which is the most widely used and spoken language in international tourism in the twenty-first century. English for tourism has a major role in the delivery of quality service. Employees who work in the tourism and hospitality industry are…

77 FR 69679 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-20

... Sponsoring ETP Holder for the Sponsored Participant, including, among other things, criteria related to order... surrounding ports or port fees and that the Exchange is not aware of any problems that port users would have... gateway software and hardware enhancements and resources dedicated to gateway development, quality...

78 FR 5236 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-24

... Exchange's integrated billing system (``IBS''). \\3\\ Exchange Rule 1.5 defines the term ``ETP'' as an Equity... Exchange and vendor invoices for Exchange-related services through the Exchange's IBS. Definition of... Holders to pay their Exchange and vendor invoices for Exchange-related services through the Exchange's IBS...

77 FR 1766 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-11

..., which Items have been prepared by the Exchange. The Commission is publishing this notice to solicit... ETP ID.\\5\\ \\4\\ See supra note 3. \\5\\ The Exchange has a Common Customer Gateway (``CCG'') that... gateway software and hardware enhancements and resources dedicated to gateway development, quality...

The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development.

PubMed

Miyazaki, Masaki; Miyazaki, Kazuko; Chen, Kenian; Jin, Yi; Turner, Jacob; Moore, Amanda J; Saito, Rintaro; Yoshida, Kenichi; Ogawa, Seishi; Rodewald, Hans-Reimer; Lin, Yin C; Kawamoto, Hiroshi; Murre, Cornelis

2017-05-16

Innate and adaptive lymphoid development is orchestrated by the activities of E proteins and their antagonist Id proteins, but how these factors regulate early T cell progenitor (ETP) and innate lymphoid cell (ILC) development remains unclear. Using multiple genetic strategies, we demonstrated that E proteins E2A and HEB acted in synergy in the thymus to establish T cell identity and to suppress the aberrant development of ILCs, including ILC2s and lymphoid-tissue-inducer-like cells. E2A and HEB orchestrated T cell fate and suppressed the ILC transcription signature by activating the expression of genes associated with Notch receptors, T cell receptor (TCR) assembly, and TCR-mediated signaling. E2A and HEB acted in ETPs to establish and maintain a T-cell-lineage-specific enhancer repertoire, including regulatory elements associated with the Notch1, Rag1, and Rag2 loci. On the basis of these and previous observations, we propose that the E-Id protein axis specifies innate and adaptive lymphoid cell fate. Copyright © 2017 Elsevier Inc. All rights reserved.

Reuse of textile effluent treatment plant sludge in building materials.

PubMed

Balasubramanian, J; Sabumon, P C; Lazar, John U; Ilangovan, R

2006-01-01

This study examines the potential reuse of textile effluent treatment plant (ETP) sludge in building materials. The physico-chemical and engineering properties of a composite textile sludge sample from the southern part of India have been studied. The tests were conducted as per Bureau of Indian Standards (BIS) specification codes to evaluate the suitability of the sludge for structural and non-structural application by partial replacement of up to 30% of cement. The cement-sludge samples failed to meet the required strength for structural applications. The strength and other properties met the Bureau of Indian Standards for non-structural materials such as flooring tiles, solid and pavement blocks, and bricks. Results generally meet most ASTM standards for non-structural materials, except that the sludge-amended bricks do not meet the Grade NW brick standard. It is concluded that the substitution of textile ETP sludge for cement, up to a maximum of 30%, may be possible in the manufacturing of non-structural building materials. Detailed leachability and economic feasibility studies need to be carried out as the next step of research.

Blood Hypomethylation of Inflammatory Genes Mediates the Effects of Metal-rich Airborne Pollutants on Blood Coagulation

PubMed Central

Tarantini, Letizia; Bonzini, Matteo; Tripodi, Armando; Angelici, Laura; Nordio, Francesco; Cantone, Laura; Apostoli, Pietro; Bertazzi, Pier Alberto; Baccarelli, Andrea A.

2014-01-01

Objectives Recent investigations have associated airborne Particulate Matter (PM) with increased coagulation and thrombosis, but underlying biological mechanisms are still incompletely characterized. DNA methylation is an environmentally-sensitive mechanism of gene regulation that could potentially contribute to PM-induced hypercoagulability. We aimed to test whether altered methylation mediates environmental effects on coagulation. Methods We investigated 63 steel workers exposed to a wide range of PM levels, as a work-related condition with well-characterized prothrombotic exposure. We measured personal PM10 (PM≤10 μm in aerodynamic diameter), PM1 (≤1 μm), and air metal components. We determined leukocyte DNA methylation of NOS3 (nitric-oxide-synthase-3) and EDN1 (endothelin-1) through bisulfite-pyrosequencing and we measured Endogenous Thrombin Potential (ETP), as a global coagulation-activation test after standardized triggers. Results ETP increased in association with PM10 (β=20.0, 95%CI: 3.0, 37.0), PM1 (β=80.8 95%CI: 14.9, 146.7), and zinc (β=51.3, 95%CI: 0.01, 111.1) exposures. NOS3 methylation was negatively associated with PM10 (β=−0.2, 95%CI: −0.4, −0.03), PM1 (β=−0.8, 95%CI: −1.4, −0.1), zinc (β=−0.9, 95%CI: −1.4, −0.3) and iron (β=−0.7, 95%CI: −1.4, −0.01) exposures. Zinc exposure was negatively associated with EDN1 (β=−0.3, 95%CI: −0.8, −0.1) methylation. Lower NOS3 (β=−42.3; p<0.001) and EDN1 (β=−14.5; p=0.05) were associated with higher ETP. Statistical mediation analysis formally confirmed NOS3 and EDN1 hypomethylation as intermediate mechanisms for PM-related coagulation effects. Conclusions Our study showed for the first time, that gene hypomethylation contributes to environmentally-induced hypercoagulability. PMID:23476046

Effects of thromboprophylactic doses of apixaban and rivaroxaban on coagulation and thrombin generation in association with total hip replacement.

PubMed

Helin, Tuukka A; Virtanen, Lauri; Manninen, Mikko; Leskinen, Jarkko; Leppilahti, Juhana; Joutsi-Korhonen, Lotta; Lassila, Riitta

2017-05-01

Factor Xa inhibitors (FXaI) apixaban and rivaroxaban are used for thromboprophylaxis after major elective orthopaedic surgery. Because few patient sample studies exist, we postoperatively assessed patients undergoing unilateral total hip arthroplasty, including 22 treated with apixaban (2.5 mg BID) and 20 treated with rivaroxaban (10 mg OD). We collected blood samples before and 3 h after drug intake at 4 time points, preoperatively, as well as on day 1, week 1 (day 2-8) and day 28 post-operation. APTT and PT were immediately analysed. Calibrated anti-FXa activity, Russel's Viper Venom Time (RVVT) and thrombin generation (TG; Calibrated Automated Thrombogram ® ) captured the effects of FXaI on coagulation and TG. APTT and PT remained within the reference interval throughout, and did not correlate with FXaI levels (PT R 2  = 0.44, APTT R 2  = 0.07). Mean apixaban concentration at the peak varied by eightfold (19-153 ng/mL), but rivaroxaban only by 1.5-fold (111-183 ng/mL). Rivaroxaban, but not apixaban prolonged RVVT at peak levels. Both FXaIs had a prolonged lag time of TG (p < 0.001). Rivaroxaban decreased ETP peak at all time points and reached a minimum at day 28 (540 nM/min at rivaroxaban 184 ng/mL, p < 0.001), while rivaroxaban trough levels were low and ETP values normal. However, with apixaban, after an initial decrease, ETP did not differ between peak and trough levels until decreasing on day 28 at peak (990 nM/min at apixaban 112 ng/mL, p = 0.005). In conclusion, due to different dosing and pharmacology rivaroxaban and apixaban distinctly inhibited TG under postoperative conditions.

An in vitro study of the effects of t-PA and tranexamic acid on whole blood coagulation and fibrinolysis.

PubMed

Godier, Anne; Parmar, Kiran; Manandhar, Karuna; Hunt, Beverley J

2017-02-01

Acute traumatic coagulopathy is characterised by fibrinolysis and low fibrinogen. It is unclear how much fibrinogenolysis contributes to reduce fibrinogen levels. The study aim was to: investigate in vitro the effects of tissue-plasminogen activator (t-PA) and tranexamic acid (TXA) on coagulation and fibrinolysis. Whole blood was spiked with varying t-PA concentrations. Clauss fibrinogen levels and thrombelastography (TEG, Haemonetics) were performed, including functional fibrinogen level (FLEV). TXA effects were assessed using four TXA concentrations. Recorded parameters from kaolin activated TEG included maximal amplitude (MA), clot strength (G), percentage lysis (LY). Plasmin-antiplasmin complex (PAP), endogenous thrombin potential (ETP), prothrombin fragment 1+2 (PF1+2), factor V and factor VIII levels were all measured. t-PA induced fibrinolysis: it increased PAP and LY, but decreased MA and G. t-PA induced fibrinogenolysis, with a concentration-dependant decrease in fibrinogen from 2.7 (2.6-3.1) to 0.8 (0.8-0.9) g/L with 60 nM t-PA. FLEV and fibrinogen levels were well correlated. High t-PA doses increased PF1+2, decreased ETP of 19% and FVIII of 63% but not FV. TXA had no effect on plasmin generation as evidenced by no change in PAP. It corrected LY, MA and G and partly protected fibrinogen against fibrinogenolysis: 0.03 mg/mL TXA reduced the fibrinogen fall induced by t-PA 20 nM from 43% to 14%. TXA halved the FVIII fall and increased ETP. t-PA induced plasminogen activation and fibrinogenolysis in a concentration-dependant manner. TXA did not affect plasmin activation but reduced fibrinogenolysis. These results suggest that TXA given early in bleeding patients may prevent fibrinogenolysis. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

The Effect of the Transit of Venus on ACRIM's Total Solar Irradiance Measurements: Implications for Transit Studies of Extrasolar Planets

NASA Astrophysics Data System (ADS)

Schneider, G.; Pasachoff, J. M.; Willson, Richard C.

2006-04-01

We have used the 2004 June 8 transit of Venus (ToV) as a surrogate to test observing methods, strategies, and techniques that are being contemplated for future space missions to detect and characterize extrasolar terrestrial planets (ETPs) as they transit their host stars, notably NASA's Kepler mission, planned for 2008. As an analog to ``Kepler-like'' photometric transit observations, we obtained (spatially unresolved) radiometric observations with the ACRIM 3 instrument on ACRIMSAT at a sampling cadence of 131 s to follow the effect of the ToV on the total solar irradiance (TSI). Contemporaneous high-resolution broadband imagery with NASA's TRACE spacecraft provided, directly, measures of the stellar (solar) astrophysical noise that can intrinsically limit such transit observations. During the Venus transit, which lasted ~5.5 hr, the planet's angular diameter was approximately 1/32 the solar diameter, thus covering ~0.1% of the stellar surface. With our ACRIM 3 data, we measure temporal changes in TSI with a 1 σ per sample (unbinned) uncertainty of approximately 100 mW m-2 (0.007%). A diminution in TSI of ~1.4 W m-2 (~0.1%, closely corresponding to the geometrically occulted area of the photosphere) was measured at mid-transit compared with a mean pre-/post-transit TSI of ~1365.9 W m-2. The radiometric light curve is complex because of the parallactic motion of Venus induced by ACRIMSAT's near-polar orbit, but exhibits the characteristic signature of photospheric limb darkening. These observations serve as a surrogate for future photometric observations of ETPs, such as Kepler will deliver. Detailed analysis of the ToV, a rare event within our own solar system, with time-resolved radiometry augmented with high-resolution imagery, provides a useful analog for investigating the detectability and characterization of ETPs from observations that are anticipated in the near future.

77 FR 56886 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-14

...'') issued pursuant to Exchange Rule 16.1(a) to introduce different Fee Schedules including liquidity adding rebates and liquidity removal fees. The Exchange proposes to adopt a Fee Schedule which allows Equity... greater than one dollar. ETP Holders can choose between a Variable Fee Schedule, which offers a liquidity...

77 FR 33010 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-04

... or options on futures, or any other related derivatives, which the ETP Holder acting as registered... or commodity, related futures or options on futures, or any other related derivatives, in an account... option or a security futures product, whose value is based, in whole or in part, upon the performance of...

77 FR 74533 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-14

... ``Fee Schedule'') issued pursuant to Exchange Rule 16.1(a) to: (1) Modify the Quotation Update Fee charged for each quotation update \\3\\ transmitted to the Exchange by an Equity Trading Permit (``ETP'') \\4\\ Holder using the Exchange's Order Delivery mode (``Order Delivery Mode''); and (2) cap the Quotation...

75 FR 39081 - Self-Regulatory Organizations; Notice of Filing of a Proposed Rule Change by The NASDAQ Stock...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-07

... 1000'') and specified Exchange Traded Products (``ETP'') to the pilot rule. The text of the proposed...\\ Changes are marked to the rule text that appears in the electronic manual of NASDAQ found at http... last-sale price disseminated by a network processor over a five minute rolling period measured...

77 FR 34448 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-11

... Rules and Procedures in Order To Approve Apex Clearing Corporation, f/k/a Ridge Clearing and Outsourcing... Clearing Corporation, f/k/a Ridge Clearing and Outsourcing Solutions, Inc. (``Apex Clearing'') as an NSX... regarding the application process for ETP Holders in order to immediately approve Apex Clearing as an NSX...

2008 Enterprise Transition Plan (ETP)

DTIC Science & Technology

2008-09-30

of contract data to entitlement systems . • Close coordination with contracting office resulted in an increase in the successful electronic ...2005 to the Fall of 2007, the DBSMC approved funding for 304 individual systems , representing $7.5B in modernization investment funding. These...industry has developed the processes and learned its lessons from working in Africa for generations . Leveraging this experience is

77 FR 11608 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-27

... months that a Tier I corporate security is listed on the Exchange pursuant to Rule 14.8. Such listing... corporate security is listed on the Exchange, and for all ETPs, the Exchange proposes to offer a $250 daily... underlying securities or products, market making for a corporate issue requires additional analysis and...

75 FR 39074 - Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing of Proposed Rule Change To...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-07

... but not in the stocks that underlie that ETF, what consequences might that have for the underlying stocks or other products? What are the potential effects on price discovery for the ETF, the underlying..., ETPs include Exchange Traded Funds (``ETF''),\\3\\ Exchange Traded Vehicles (``ETV''),\\4\\ and Exchange...

75 FR 39084 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing of Proposed Rule Change To...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-07

... there are trading pauses in an ETF but not in the stocks that underlie that ETF, what consequences might... discovery for the ETF, the underlying stocks and other products? Are there other market-based... filing, ETPs include Exchange Traded Funds (``ETF''),\\3\\ Exchange Traded Vehicles (``ETV''),\\4\\ and...

77 FR 9277 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-16

... Change Amending the NYSE Arca Equities Fee Schedule Increasing the Indication of Interest Tier 1 Credit and the Tracking Order Tier 1 Credit for ETP Holders and Market Makers February 10, 2012. Pursuant to... Schedule'') to increase the indication of interest (``IOI'') Tier 1 credit and the Tracking Order Tier 1...

78 FR 15364 - Gulf Crossing Pipeline Company LLC; Notice of Intent To Prepare an Environmental Assessment for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-11

... Sherman Compressor Station located 10 miles northeast of Sherman, Texas, to Panda Sherman Power, LLC's... barrel and meter station consisting of a 16-inch receiver barrel and associated piping and valves at MP... control station to be built, owned, and operated by ETP. The general location of the project facilities is...

An Evaluation of the Individual Training Account/Eligible Training Provider Demonstration. Final Interim Report.

ERIC Educational Resources Information Center

D'Amico, Ronald; Martinez, Alexandria; Salzman, Jeffrey; Wagner, Robin

In March 2000, thirteen grants were awarded as part of the Individual Training Account/Eligible Training Provider (ITA/ETP) Demonstration. In summer and fall of 2000, the grant recipients' activities were subjected to an interim evaluation. Site visits were made to each grantee to determine what ITA policies and practices were being formulated,…

78 FR 35340 - Self-Regulatory Organizations; NYSE Arca, Inc.; Order Granting Approval of a Proposed Rule Change...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-12

... time frame and can also take advantage of predefined symbol sets based on type of ETP or issuer. Users... marketplace and have an opportunity to receive adequate support from the market making community, as the... fairly easy for either the Exchange or the Commission to alter or terminate with little or no negative...

77 FR 74536 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-14

... Participants will post additional liquidity on the Exchange if it (i) increases the rebate to $0.0030 per share when the Order Deliver [sic] Participant adds liquidity in a security quoted at a price of $1.00 or... ETP Holders with an incentive to post additional liquidity on the Exchange via Order Delivery Mode...

78 FR 41966 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-12

... after its initial route to the designated away Trading Center,\\6\\ and subsequently executed on the NSX or routed away in accordance with NSX Rule 11.15(a)(ii) is subject to the standard Fee Schedule; and... orders for which an ETP Holder instructs the System to route to designated away Trading Centers which are...

77 FR 51076 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-23

... offer or agreement to sell or provide any goods or services, a provision under which a customer receives... product or service offered by the ETP Holder within the three months immediately preceding the date of an... condition of purchasing any good or service; (c) evidence the willingness of the called person to receive...

77 FR 56683 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-13

... the Tape A Step Up Tier, Modify the Remaining Tape Step Up Tiers and Introduce an Alternative Method... and Charges for Exchange Services (``Fee Schedule'') to (i) eliminate the Tape A Step Up Tier; (ii) modify the remaining Tape Step Up Tiers to exclude ETP Holders that qualify for the Cross-Asset Tier or...

75 FR 39076 - Self-Regulatory Organizations; Notice of Filing of Proposed Rule Change by NYSE Arca, Inc...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-07

... index? If there are trading pauses in an ETF but not in the stocks that underlie that ETF, what... price discovery for the ETF, the underlying stocks and other products? Are there other market-based...'') to the pilot rule. For purposes of this filing, ETPs include Exchange Traded Funds (``ETF''),\\4...

75 FR 47049 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-04

... Derivative Security products under NSX Rule 15.9. Proposed Rule 11.1(c) provides for the benefit of ETP... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-62601; File No. SR-NSX-2010-09] Self-Regulatory... Hours July 29, 2010. Pursuant to Section 19(b)(1) of the Securities Exchange Act of 1934 (the ``Act...

78 FR 61433 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-03

... that limitations in order management systems and routing networks used by such ETP Holders may make it... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-70565; File No. SR-NYSEARCA-2013-98] Self... September 30, 2013. Pursuant to Section 19(b)(1) \\1\\ of the Securities Exchange Act of 1934 (the ``Act'') \\2...

Contribution to the study of the zonal variation of the climate aridity in central northern Sahara (Algeria)

NASA Astrophysics Data System (ADS)

Benseghier-Hadjaidji, Fatiha; Talbi, Nadjib; Derridj, Arezki

2018-05-01

The environment degradation at the level of all its compartments which we notice at present, calls us to the risks that it would underestimate the climatic and consequently bioclimatic crisis there, in the North as in the South of the Mediterranean region. To protect the environment is not a luxury. In this respect, we wondered about the zonal variation of the climate aridity at the level of three bordering climatic stations: El-Oued, Touggourt and Ouargla. These are distant from 160 km on average some of the others. For that purpose, we based ourselves on the statistical tool the software "instat +" for the estimation of the ETP (PM) and afterward the determination of the pluvio-evapotranspiration "quotient P/ETP". For this analysis, the climatic data spread out over a period of 20 years. The results allowed to specify the aridity degree of the studied zone. So, they reveal a mitigation of the aridity of the climate in Touggourt and El-Oued while the hyper-aridity distinguishes well the Ouargla region. This approach contributes to a better knowledge of the dry ecosystems. This is important to indicate it to turn better in the eremologic search later.

[Neoadjuvant chemotherapy for advanced gastric cancer using FLEP therapy].

PubMed

Mochizuki, F; Fujii, M; Kasakura, Y; Kochi, M; Imai, S; Eguchi, T; Tsuneda, Y; Kanamori, N; Kaiga, T; Kobayashi, M

2000-10-01

Combination chemotherapy with 5-FU, LV, ETP and CDDP (FLEP) for advanced gastric cancer uses a combination of regional and systemic delivery for the control of both local and disseminated disease in the intra- and extra-abdominal regions. We performed this regimen as neoadjuvant chemotherapy (NAC). Fifteen patients with unresectable primary advanced gastric cancer underwent FLEP. The treatment regimen was 5-FU at 370 mg/m2, LV at 30 mg/body (days 1 to 5, i.v. 24 h) and ETP and CDDP each at 70 mg/m2 (days 7 and 21, ia 2 h). This regimen was repeated every four weeks. The overall response rate was 46.7% (7/15), and the 50% and median survival times were 11.43 and 12.35 months, respectively. The adverse events were Grade 3 leukocytopenia, Grade 3 thrombocytopenia, and Grade 3 stomatitis in 20.0%, 13.3%, and 6.7% of the patients, respectively. The 50% and median survival time overall were 11.43 and 12.35 months, respectively. Of the 15 NAC patients, curability B patients showed a statistically higher survival rate than curability C and unresected patients. In conclusion, FLEP was effective for unresectable advanced gastric cancer.

Tuning electronic transport via hepta-alanine peptides junction by tryptophan doping.

PubMed

Guo, Cunlan; Yu, Xi; Refaely-Abramson, Sivan; Sepunaru, Lior; Bendikov, Tatyana; Pecht, Israel; Kronik, Leeor; Vilan, Ayelet; Sheves, Mordechai; Cahen, David

2016-09-27

Charge migration for electron transfer via the polypeptide matrix of proteins is a key process in biological energy conversion and signaling systems. It is sensitive to the sequence of amino acids composing the protein and, therefore, offers a tool for chemical control of charge transport across biomaterial-based devices. We designed a series of linear oligoalanine peptides with a single tryptophan substitution that acts as a "dopant," introducing an energy level closer to the electrodes' Fermi level than that of the alanine homopeptide. We investigated the solid-state electron transport (ETp) across a self-assembled monolayer of these peptides between gold contacts. The single tryptophan "doping" markedly increased the conductance of the peptide chain, especially when its location in the sequence is close to the electrodes. Combining inelastic tunneling spectroscopy, UV photoelectron spectroscopy, electronic structure calculations by advanced density-functional theory, and dc current-voltage analysis, the role of tryptophan in ETp is rationalized by charge tunneling across a heterogeneous energy barrier, via electronic states of alanine and tryptophan, and by relatively efficient direct coupling of tryptophan to a Au electrode. These results reveal a controlled way of modulating the electrical properties of molecular junctions by tailor-made "building block" peptides.

A Zn(II)2Cys6 DNA binding protein regulates the sirodesmin PL biosynthetic gene cluster in Leptosphaeria maculans

PubMed Central

Fox, Ellen M.; Gardiner, Donald M.; Keller, Nancy P.; Howlett, Barbara J.

2008-01-01

A gene, sirZ, encoding a Zn(II)2Cys6 DNA binding protein is present in a cluster of genes responsible for the biosynthesis of the epipolythiodioxopiperazine (ETP) toxin, sirodesmin PL in the ascomycete plant pathogen, Leptosphaeria maculans. RNA-mediated silencing of sirZ gives rise to transformants that produce only residual amounts of sirodesmin PL and display a decrease in the transcription of several sirodesmin PL biosynthetic genes. This indicates that SirZ is a major regulator of this gene cluster. Proteins similar to SirZ are encoded in the gliotoxin biosynthetic gene cluster of Aspergillus fumigatus (gliZ) and in an ETP-like cluster in Penicillium lilacinoechinulatum (PlgliZ). Despite its high level of sequence similarity to gliZ, PlgliZ is unable to complement the gliotoxin-deficiency of a mutant of gliZ in A. fumigatus. Putative binding sites for these regulatory proteins in the promoters of genes in these clusters were predicted using bioinformatic analysis. These sites are similar to those commonly bound by other proteins with Zn(II)2Cys6 DNA binding domains. PMID:18023597

Recovery technologies for building materials

NASA Astrophysics Data System (ADS)

Karu, Veiko; Nurme, Martin; Valgma, Ingo

2015-04-01

Mining industry provides building materials for construction. Civil engineers have settled the quality parameters for construction materials. When we produce high quality building materials from carbonate rock (limestone, dolostone), then the estimated waste share is 25% to 30%, depending on crushing principles and rock quality. The challenge is to find suitable technology for waste recovery. During international mining waste related cooperation project MIN-NOVATION (www.min-novation.eu), partners mapped possibilities for waste recovery in mining industry and pointed out good examples and case studies. One example from Estonia showed that when we produce limestone aggregate, then we produce up to 30% waste material (fines with size 0-4mm). This waste material we can see as secondary raw material for building materials. Recovery technology for this fine grained material has been achieved with CDE separation plant. During the process the plant washes out minus 63 micron material from the limestone fines. This technology allows us to use 92% of all limestone reserves. By-product from 63 microns to 4 mm we can use as filler in concrete or as fine limestone aggregate for building or building materials. MIN-NOVATION project partners also established four pilot stations to study other mineral waste recovery technologies and solutions. Main aims on this research are to find the technology for recovery of mineral wastes and usage for new by-products from mineral mining waste. Before industrial production, testing period or case studies are needed. This research is part of the study of Sustainable and environmentally acceptable Oil shale mining No. 3.2.0501.11-0025 http://mi.ttu.ee/etp and the project B36 Extraction and processing of rock with selective methods - http://mi.ttu.ee/separation; http://mi.ttu.ee/miningwaste/

Progress of teaching and learning of nuclear engineering courses at College of Engineering, Universiti Tenaga Nasional (UNITEN)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hamid, Nasri A., E-mail: Nasri@uniten.edu.my; Mohamed, Abdul Aziz; Yusoff, Mohd. Zamri

Developing human capital in nuclear with required nuclear background and professional qualifications is necessary to support the implementation of nuclear power projects in the near future. Sufficient educational and training skills are required to ensure that the human resources needed by the nuclear power industry meets its high standard. The Government of Malaysia has made the decision to include nuclear as one of the electricity generation option for the country, post 2020 in order to cater for the increasing energy demands of the country as well as to reduce CO{sub 2} emission. The commitment by the government has been mademore » clearer with the inclusion of the development of first NPP by 2021 in the Economic Transformation Program (ETP) which was launched by the government in October 2010. The In tandem with the government initiative to promote nuclear energy, Center for Nuclear Energy, College of Engineering, Universiti Tenaga Nasional (UNITEN) is taking the responsibility in developing human capital in the area of nuclear power and technology. In the beginning, the College of Engineering has offered the Introduction to Nuclear Technology course as a technical elective course for all undergraduate engineering students. Gradually, other nuclear technical elective courses are offered such as Nuclear Policy, Security and Safeguards, Introduction to Nuclear Engineering, Radiation Detection and Nuclear Instrumentation, Introduction to Reactor Physics, Radiation Safety and Waste Management, and Nuclear Thermal-hydraulics. In addition, another course Advancement in Nuclear Energy is offered as one of the postgraduate elective courses. To enhance the capability of teaching staffs in nuclear areas at UNITEN, several junior lecturers are sent to pursue their postgraduate studies in the Republic of Korea, United States and the United Kingdom, while the others are participating in short courses and workshops in nuclear that are conducted locally and abroad. This paper describes the progress of teaching and learning in nuclear engineering and technology at UNITEN that include curriculum development, students’ enrolment and performance, and teaching staff’s human resource development.« less

Actual evapotranspiration modeling using the operational Simplified Surface Energy Balance (SSEBop) approach

USGS Publications Warehouse

Savoca, Mark E.; Senay, Gabriel B.; Maupin, Molly A.; Kenny, Joan F.; Perry, Charles A.

2013-01-01

Remote-sensing technology and surface-energy-balance methods can provide accurate and repeatable estimates of actual evapotranspiration (ETa) when used in combination with local weather datasets over irrigated lands. Estimates of ETa may be used to provide a consistent, accurate, and efficient approach for estimating regional water withdrawals for irrigation and associated consumptive use (CU), especially in arid cropland areas that require supplemental water due to insufficient natural supplies from rainfall, soil moisture, or groundwater. ETa in these areas is considered equivalent to CU, and represents the part of applied irrigation water that is evaporated and/or transpired, and is not available for immediate reuse. A recent U.S. Geological Survey study demonstrated the application of the remote-sensing-based Simplified Surface Energy Balance (SSEB) model to estimate 10-year average ETa at 1-kilometer resolution on national and regional scales, and compared those ETa values to the U.S. Geological Survey’s National Water-Use Information Program’s 1995 county estimates of CU. The operational version of the operational SSEB (SSEBop) method is now used to construct monthly, county-level ETa maps of the conterminous United States for the years 2000, 2005, and 2010. The performance of the SSEBop was evaluated using eddy covariance flux tower datasets compiled from 2005 datasets, and the results showed a strong linear relationship in different land cover types across diverse ecosystems in the conterminous United States (correlation coefficient [r] ranging from 0.75 to 0.95). For example, r for woody savannas (0.75), grassland (0.75), forest (0.82), cropland (0.84), shrub land (0.89), and urban (0.95). A comparison of the remote-sensing SSEBop method for estimating ETa and the Hamon temperature method for estimating potential ET (ETp) also was conducted, using regressions of all available county averages of ETa for 2005 and 2010, and yielded correlations of r = 0.60 and r = 0.71, respectively. Correlations generally are stronger in the Southeast where ETa is close to ETp. SSEBop ETa provides more spatial detail and accuracy in the Southwest where irrigation is practiced in a smaller proportion of the region.

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A coordinated increase in export production and denitrification on the Costa Rica margin during the early Pleistocene

NASA Astrophysics Data System (ADS)

Yuan, V.; Bascom, C., Jr.; Robinson, R. S.

2013-12-01

The oceanic carbon, nitrogen, and oxygen cycles are linked through export production, oxygen consumption, and denitrification. Denitrification, the bacterial reduction of nitrate, is an anoxic process that serves as the primary sink for fixed nitrogen in the ocean. The Eastern Tropical Pacific (ETP) houses an oxygen minimum zone (OMZ) where pelagic denitrification proceeds as a result of both large scale circulation and regionally high export of organic matter that fuels oxygen consumption in the subsurface. Here we present a 2.4 million year long record of denitrification and productivity in the ETP using ODP Site 1242. Site 1242 is located ~70 km off the west coast of Costa Rica, beneath the OMZ. Downcore records of bulk sedimentary nitrogen isotope values (δ15N) and opal and organic matter accumulation rates show near synchronous increases in δ15N values and biogenic sediment accumulation at approximately 1.6 My. The concurrent increase in the denitrification and productivity proxies suggests that regional oxygen demand could be driving the increase in denitrification observed at Site 1242. This is in contrast to what is observed elsewhere, where export productivity and denitrification changes do not appear to be coupled locally. Moreover, the timing of this increase is distinct from a previously observed increase in δ15N at California Margin Site 1012 which occurred at ~2.1 Ma (Liu et al., G-cubed, 2008) and is also attributed to enhanced denitrification in the OMZ. These differences suggest that the Site 1242 record reflects a purely local or regional process. Interestingly, the later increase in denitrification at 1.6 Ma observed at Site 1242 does not appear to be restricted to the ETP, but rather shows similar timing to a δ15N shift in a site from the Arabian Sea OMZ (Muzuka et al., Proceedings of the ODP, 1991). The new data presented here will help in the development of a mechanistic understanding of relative roles of local and regional processes over global controls on intermediate water OMZ intensity.

Distribution of Classical and Nonclassical Virulence Genes in Enterotoxigenic Escherichia coli Isolates from Chilean Children and tRNA Gene Screening for Putative Insertion Sites for Genomic Islands▿†

PubMed Central

Del Canto, Felipe; Valenzuela, Patricio; Cantero, Lidia; Bronstein, Jonathan; Blanco, Jesús E.; Blanco, Jorge; Prado, Valeria; Levine, Myron; Nataro, James; Sommerfelt, Halvor; Vidal, Roberto

2011-01-01

Enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrhea. Three adhesins (Tia, TibA, EtpA), an iron acquisition system (Irp1, Irp2, and FyuA), a GTPase (LeoA), and an autotransporter (EatA) are ETEC virulence-related proteins that, in contrast to the classical virulence factors (enterotoxins and fimbrial colonization factors) have not heretofore been targets in characterizing isolates from epidemiological studies. Here, we determined the occurrence of these nonclassical virulence genes in 103 ETEC isolates from Chilean children with diarrhea and described their association with O serogroups and classical virulence determinants. Because tia, leoA, irp2, and fyuA are harbored by pathogenicity islands inserted into the selC and asnT tRNA genes (tDNAs), we analyzed the regions flanking these loci. Ten additional tDNAs were also screened to identify hot spots for genetic insertions. Associations between the most frequent serogroups and classical colonization factor (CF)-toxin profiles included O6/LT-STh/CS1-CS3-CS21 (i.e., O6 serogroup, heat-labile [LT] and human heat-stable [STh] enterotoxins, and CFs CS1, -3 and -21), O6/LT-STh/CS2-CS3-CS21, and O104-O127/STh/CFAI-CS21. The eatA and etpA genes were detected in more than 70% of the collection, including diverse serogroups and virulence profiles. Sixteen percent of the ETEC strains were negative for classical and nonclassical adhesins, suggesting the presence of unknown determinants of adhesion. The leuX, thrW, and asnT tDNAs were disrupted in more than 65% of strains, suggesting they are hot spots for the insertion of mobile elements. Sequences similar to integrase genes were identified next to the thrW, asnT, pheV, and selC tDNAs. We propose that the eatA and etpA genes should be included in characterizations of ETEC isolates in future epidemiological studies to determine their prevalence in other geographical regions. Sequencing of tDNA-associated genetic insertions might identify new ETEC virulence determinants. PMID:21775541

Variation of Vegetation Ecological Water Consumption and Its Response to Vegetation Coverage Changes in the Rocky Desertification Areas in South China

PubMed Central

Zhou, Jinxing; Guo, Hongyan; Cui, Ming; Liu, Yuguo; Ning, Like; Tang, Fukai

2016-01-01

Over the past several decades, rocky desertification has led to severe ecological problems in karst areas in South China. After a rocky desertification treatment project was completed, the vegetation coverage changed greatly and, consequently, increased the ecology water consumption (approximately equal to the actual evapotranspiration) of the regional vegetation. Thus, it intensified the regional water stresses. This study explored the changes in the actual evapotranspiration (ETa) response to the vegetation coverage changes in the rocky desertification areas in South China based on the precipitation (P), potential evapotranspiration (ETp) and NDVI (the normalized difference vegetation index) datasets. The revised Bagrov model was used to simulate the actual evapotranspiration changes with the supposed increasing NDVI. The results indicated that the average NDVI value was lower when the rocky desertification was more severe. The ETa, evapotranspiration efficiency (ETa/ETp) and potential humidity (P/ETp) generally increased with the increasing NDVI. The sensitivity of the ETa response to vegetation coverage changes varied due to different precipitation conditions and different rocky desertification severities. The ETa was more sensitive under drought conditions. When a drought occurred, the ETa exhibited an average increase of 40~60 mm with the NDVI increasing of 0.1 in the rocky desertification areas. Among the 5 different severity categories of rocky desertification, the ETa values’ responses to NDVI changes were less sensitive in the severe rocky desertification areas but more sensitive in the extremely and potential rocky desertification areas. For example, with the NDVI increasing of 0.025, 0.05, 0.075, and 0.1, the corresponding ETa changes increased by an average of 2.64 mm, 10.62 mm, 19.19 mm, and 27.58 mm, respectively, in severe rocky desertification areas but by 4.94 mm, 14.99 mm, 26.80, and 37.13 mm, respectively, in extremely severe rocky desertification areas. Understanding the vegetation ecological water consumption response to the vegetation coverage changes is essential for the vegetation restoration and water stresses mitigation in rocky desertification areas. PMID:27798642

Variation of Vegetation Ecological Water Consumption and Its Response to Vegetation Coverage Changes in the Rocky Desertification Areas in South China.

PubMed

Wan, Long; Tong, Jing; Zhou, Jinxing; Guo, Hongyan; Cui, Ming; Liu, Yuguo; Ning, Like; Tang, Fukai

2016-01-01

Over the past several decades, rocky desertification has led to severe ecological problems in karst areas in South China. After a rocky desertification treatment project was completed, the vegetation coverage changed greatly and, consequently, increased the ecology water consumption (approximately equal to the actual evapotranspiration) of the regional vegetation. Thus, it intensified the regional water stresses. This study explored the changes in the actual evapotranspiration (ETa) response to the vegetation coverage changes in the rocky desertification areas in South China based on the precipitation (P), potential evapotranspiration (ETp) and NDVI (the normalized difference vegetation index) datasets. The revised Bagrov model was used to simulate the actual evapotranspiration changes with the supposed increasing NDVI. The results indicated that the average NDVI value was lower when the rocky desertification was more severe. The ETa, evapotranspiration efficiency (ETa/ETp) and potential humidity (P/ETp) generally increased with the increasing NDVI. The sensitivity of the ETa response to vegetation coverage changes varied due to different precipitation conditions and different rocky desertification severities. The ETa was more sensitive under drought conditions. When a drought occurred, the ETa exhibited an average increase of 40~60 mm with the NDVI increasing of 0.1 in the rocky desertification areas. Among the 5 different severity categories of rocky desertification, the ETa values' responses to NDVI changes were less sensitive in the severe rocky desertification areas but more sensitive in the extremely and potential rocky desertification areas. For example, with the NDVI increasing of 0.025, 0.05, 0.075, and 0.1, the corresponding ETa changes increased by an average of 2.64 mm, 10.62 mm, 19.19 mm, and 27.58 mm, respectively, in severe rocky desertification areas but by 4.94 mm, 14.99 mm, 26.80, and 37.13 mm, respectively, in extremely severe rocky desertification areas. Understanding the vegetation ecological water consumption response to the vegetation coverage changes is essential for the vegetation restoration and water stresses mitigation in rocky desertification areas.

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The Dual Promise of Green Jobs: A Qualitative Study of Federally Funded Energy Training Programmes in the USA

ERIC Educational Resources Information Center

Scully-Russ, Ellen

2013-01-01

Purpose: The aim of this paper is to review the policy literature on green jobs and green jobs training in the USA and to present findings of a qualitative study on the start-up of two Energy Training Partnerships (ETP) funded by the US Department of Labour to train workers for green jobs. Design/methodology/approach: The paper includes a review…

Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus

PubMed Central

Dolan, Stephen K.; Bock, Tobias; Hering, Vanessa; Owens, Rebecca A.; Jones, Gary W.

2017-01-01

Gliotoxin is an epipolythiodioxopiperazine (ETP) class toxin, contains a disulfide bridge that mediates its toxic effects via redox cycling and is produced by the opportunistic fungal pathogen Aspergillus fumigatus. Self-resistance against gliotoxin is effected by the gliotoxin oxidase GliT, and attenuation of gliotoxin biosynthesis is catalysed by gliotoxin S-methyltransferase GtmA. Here we describe the X-ray crystal structures of GtmA-apo (1.66 Å), GtmA complexed to S-adenosylhomocysteine (1.33 Å) and GtmA complexed to S-adenosylmethionine (2.28 Å), providing mechanistic insights into this important biotransformation. We further reveal that simultaneous elimination of the ability of A. fumigatus to dissipate highly reactive dithiol gliotoxin, via deletion of GliT and GtmA, results in the most significant hypersensitivity to exogenous gliotoxin observed to date. Indeed, quantitative proteomic analysis of ΔgliT::ΔgtmA reveals an uncontrolled over-activation of the gli-cluster upon gliotoxin exposure. The data presented herein reveal, for the first time, the extreme risk associated with intracellular dithiol gliotoxin biosynthesis—in the absence of an efficient dismutation capacity. Significantly, a previously concealed protective role for GtmA and functionality of ETP bis-thiomethylation as an ancestral protection strategy against dithiol compounds is now evident. PMID:28179499

A High-yield Two-step Transfer Printing Method for Large-scale Fabrication of Organic Single-crystal Devices on Arbitrary Substrates

PubMed Central

Deng, Wei; Zhang, Xiujuan; Pan, Huanhuan; Shang, Qixun; Wang, Jincheng; Zhang, Xiaohong; Zhang, Xiwei; Jie, Jiansheng

2014-01-01

Single-crystal organic nanostructures show promising applications in flexible and stretchable electronics, while their applications are impeded by the large incompatibility with the well-developed photolithography techniques. Here we report a novel two-step transfer printing (TTP) method for the construction of organic nanowires (NWs) based devices onto arbitrary substrates. Copper phthalocyanine (CuPc) NWs are first transfer-printed from the growth substrate to the desired receiver substrate by contact-printing (CP) method, and then electrode arrays are transfer-printed onto the resulting receiver substrate by etching-assisted transfer printing (ETP) method. By utilizing a thin copper (Cu) layer as sacrificial layer, microelectrodes fabricated on it via photolithography could be readily transferred to diverse conventional or non-conventional substrates that are not easily accessible before with a high transfer yield of near 100%. The ETP method also exhibits an extremely high flexibility; various electrodes such as Au, Ti, and Al etc. can be transferred, and almost all types of organic devices, such as resistors, Schottky diodes, and field-effect transistors (FETs), can be constructed on planar or complex curvilinear substrates. Significantly, these devices can function properly and exhibit closed or even superior performance than the device counterparts fabricated by conventional approach. PMID:24942458

Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus.

PubMed

Dolan, Stephen K; Bock, Tobias; Hering, Vanessa; Owens, Rebecca A; Jones, Gary W; Blankenfeldt, Wulf; Doyle, Sean

2017-02-01

Gliotoxin is an epipolythiodioxopiperazine (ETP) class toxin, contains a disulfide bridge that mediates its toxic effects via redox cycling and is produced by the opportunistic fungal pathogen Aspergillus fumigatus Self-resistance against gliotoxin is effected by the gliotoxin oxidase GliT, and attenuation of gliotoxin biosynthesis is catalysed by gliotoxin S -methyltransferase GtmA. Here we describe the X-ray crystal structures of GtmA-apo (1.66 Å), GtmA complexed to S -adenosylhomocysteine (1.33 Å) and GtmA complexed to S -adenosylmethionine (2.28 Å), providing mechanistic insights into this important biotransformation. We further reveal that simultaneous elimination of the ability of A. fumigatus to dissipate highly reactive dithiol gliotoxin, via deletion of GliT and GtmA, results in the most significant hypersensitivity to exogenous gliotoxin observed to date. Indeed, quantitative proteomic analysis of Δ gliT ::Δ gtmA reveals an uncontrolled over-activation of the gli -cluster upon gliotoxin exposure. The data presented herein reveal, for the first time, the extreme risk associated with intracellular dithiol gliotoxin biosynthesis-in the absence of an efficient dismutation capacity. Significantly, a previously concealed protective role for GtmA and functionality of ETP bis -thiomethylation as an ancestral protection strategy against dithiol compounds is now evident. © 2017 The Authors.

IscR Regulates Synthesis of Colonization Factor Antigen I Fimbriae in Response to Iron Starvation in Enterotoxigenic Escherichia coli

PubMed Central

Arnaud-Barbe, Nadège; Poncet, David; Reverchon, Sylvie; Wawrzyniak, Julien; Nasser, William

2015-01-01

ABSTRACT Iron availability functions as an environmental cue for enteropathogenic bacteria, signaling arrival within the human host. As enterotoxigenic Escherichia coli (ETEC) is a major cause of human diarrhea, the effect of iron on ETEC virulence factors was evaluated here. ETEC pathogenicity is directly linked to production of fimbrial colonization factors and secretion of heat-labile enterotoxin (LT) and/or heat-stable enterotoxin (ST). Efficient colonization of the small intestine further requires at least the flagellin binding adhesin EtpA. Under iron starvation, production of the CFA/I fimbriae was increased in the ETEC H10407 prototype strain. In contrast, LT secretion was inhibited. Furthermore, under iron starvation, gene expression of the cfa (CFA/I) and etp (EtpBAC) operons was induced, whereas transcription of toxin genes was either unchanged or repressed. Transcriptional reporter fusion experiments focusing on the cfa operon further showed that iron starvation stimulated cfaA promoter activity in ETEC, indicating that the impact of iron on CFA/I production was mediated by transcriptional regulation. Evaluation of cfaA promoter activity in heterologous E. coli single mutant knockout strains identified IscR as the regulator responsible for inducing cfa fimbrial gene expression in response to iron starvation, and this was confirmed in an ETEC ΔiscR strain. The global iron response regulator, Fur, was not implicated. IscR binding sites were identified in silico within the cfaA promoter and fixation confirmed by DNase I footprinting, indicating that IscR directly binds the promoter region to induce CFA/I. IMPORTANCE Pathogenic enterobacteria modulate expression of virulence genes in response to iron availability. Although the Fur transcription factor represents the global regulator of iron homeostasis in Escherichia coli, we show that several ETEC virulence factors are modulated by iron, with expression of the major fimbriae under the control of the iron-sulfur cluster regulator, IscR. Furthermore, we demonstrate that the apo form of IscR, lacking an Fe-S cluster, is able to directly fix the corresponding promoter region. These results provide further evidence implicating IscR in bacterial virulence and suggest that IscR may represent a more general regulator mediating the iron response in enteropathogens. PMID:26124243

Urinary concentrations of parabens and their association with demographic factors: A population-based cross-sectional study.

PubMed

Kang, Hui-Seung; Kyung, Min-Sik; Ko, Ahra; Park, Jae-Hong; Hwang, Myung-Sil; Kwon, Ji-Eun; Suh, Jin-Hyang; Lee, Hee-Seok; Moon, Gui Im; Hong, Jin-Hwan; Hwang, In Gyun

2016-04-01

Parabens are broad-spectrum antimicrobial agents used in a range of consumer products, including personal care products, cosmetics, and food. Recently, the widespread use of parabens has raised concerns about the potential health risks associated with their endocrine-disrupting effect. In the present study, 2541 urine samples were collected and analyzed by liquid chromatography-mass spectrometry for the determination of the concentrations of methyl paraben (MeP), ethyl paraben (EtP), propyl paraben (PrP) and butyl paraben (BuP). The detection rate and geometric mean concentrations of parabens in the general population followed the order MeP (97.7%; 116ng/mL)>EtP (97.2%; 24.7ng/mL)>PrP (96.7%; 11.0ng/mL)>BuP (83.5%; 1.13ng/mL). The composition profiles showed that MeP and EtP accounted for >90% of the urinary paraben concentration. We performed statistical analysis in order to evaluate differences between demographic variables and urinary concentrations. Our results showed that adjusted proportional change of MeP, PrP, and BuP in adults were 2.67-6.13 times higher in females than in males. The urinary concentrations of PrP in adults increased significantly with age. The adjusted proportional changes of MeP and PrP in adults were associated with increased body mass index (BMI). The adjusted proportional changes of BuP and PrP in children and adolescents were 1.44 and 1.69 times higher in females than in males. However, there was no clear association between paraben concentrations and demographic variables in the children and adolescents groups. The estimated daily intake (EDIurine) of MeP and EtP in adults were 301μg/kg bw/day, which is lower than the acceptable daily intake (ADI; 10mg/kg bw/day). In summary, our results revealed that the general population in Korea was exposed to parabens during 2009-2010, and most Koreans are exposed to parabens. The urinary levels of parabens varied by age group with demographic factors in the Korean population. The results of study may be used to establish a nationally representative baseline of exposure to parabens in risk assessment. Copyright © 2016. Published by Elsevier Inc.

RUBBER BEARINGS FOR DOWN-HOLE PUMPS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bob Sullivan Mammoth Pacific, L.P.

2005-09-07

Synopsis of project activity: 1998--Awarded cost share grant from DOE. 1st Qtr 1999--Developed fail safe lubricating system. 2nd Qtr 1999--Performed first large scale test with nitrile based bearings. It failed due to material swelling. Failure was blamed on improper tolerance. 3rd Qtr 1999--Material tests were performed with autoclaves and exposure tests to Casa Diablo fluids. Testing of Viton materials began. Alternate bearing designs were developed to limit risk of improper tolerances. 4th Qtr 1999--Site testing indicated a chemical attack on the bearing material caused the test failure and not improper bearing tolerance. 1st Qtr 2000--The assistance of Brookhaven National Laboratorymore » was obtained in evaluating the chemical attack. The National Laboratory also began more elaborate laboratory testing on bearing materials. 2nd Qtr 2000--Testing indicated Viton was an inappropriate material due to degradation in Casa Diablo fluid. Testing of EPDM began. 3rd Qtr 2001--EPDM bearings were installed for another large scale test. Bearings failed again due to swelling. Further testing indicated that larger then expected oil concentrations existed in lubricating water geothermal fluid causing bearing failure. 2002-2003--Searched for and tested several materials that would survive in hot salt and oil solutions. Kalrez{reg_sign}, Viton{reg_sign}ETP 500 and Viton{reg_sign}GF were identified as possible candidates. 2003-2005--Kalrez{reg_sign}has shown superior resistance to downhole conditions at Casa Diablo from among the various materials tested. Viton ETP-500 indicated a life expectancy of 13 years and because it is significantly less expensive then Kalrez{reg_sign}, it was selected as the bearing material for future testing. Unfortunately during the laboratory testing period Dupont Chemical chose to stop manufacturing this specific formulation and replaced it with Viton ETP 600S. The material is available with six different fillers; three based on zinc oxide and three based on silicon oxide. Samples of all six materials have been obtained and are being tested at the National Laboratory in Brookhaven, New York. This new material's properties as a bearing material and its ability to adhere to a bearings shell must be reviewed, but cost information deemed the material to be too expensive to be economical.« less

Ammunition Suite for the FCS Multi-role Armament and Ammunition System (MRAAS)

DTIC Science & Technology

2001-06-20

Cards Large Scale Gap Test (LSGT) Exploding Foil Initiator ( EFI ) Effort 19 Slow Burning Layer Fast Burning Layer FASTCORE Nitramines ETPEs RDX CL20...Center Burst Charge 48 M80 Grenades With Center Burst Charge ü Trade off performance with size, weight, etc. ü Develop initial space claim for...submunition ü Dynamic Analysis of projectile for different submunitions MRAAS Trades underway • Accomplishments – Initial meetings with TRADOC, Ft Knox and Ft

Antifungal activity of microbial secondary metabolites.

PubMed

Coleman, Jeffrey J; Ghosh, Suman; Okoli, Ikechukwu; Mylonakis, Eleftherios

2011-01-01

Secondary metabolites are well known for their ability to impede other microorganisms. Reanalysis of a screen of natural products using the Caenorhabditis elegans-Candida albicans infection model identified twelve microbial secondary metabolites capable of conferring an increase in survival to infected nematodes. In this screen, the two compound treatments conferring the highest survival rates were members of the epipolythiodioxopiperazine (ETP) family of fungal secondary metabolites, acetylgliotoxin and a derivative of hyalodendrin. The abundance of fungal secondary metabolites indentified in this screen prompted further studies investigating the interaction between opportunistic pathogenic fungi and Aspergillus fumigatus, because of the ability of the fungus to produce a plethora of secondary metabolites, including the well studied ETP gliotoxin. We found that cell-free supernatant of A. fumigatus was able to inhibit the growth of Candida albicans through the production of a secreted product. Comparative studies between a wild-type and an A. fumigatus ΔgliP strain unable to synthesize gliotoxin demonstrate that this secondary metabolite is the major factor responsible for the inhibition. Although toxic to organisms, gliotoxin conferred an increase in survival to C. albicans-infected C. elegans in a dose dependent manner. As A. fumigatus produces gliotoxin in vivo, we propose that in addition to being a virulence factor, gliotoxin may also provide an advantage to A. fumigatus when infecting a host that harbors other opportunistic fungi.

Estimation of evapotranspiration across the conterminous United States using a regression with climate and land-cover data

USGS Publications Warehouse

Sanford, Ward E.; Selnick, David L.

2013-01-01

Evapotranspiration (ET) is an important quantity for water resource managers to know because it often represents the largest sink for precipitation (P) arriving at the land surface. In order to estimate actual ET across the conterminous United States (U.S.) in this study, a water-balance method was combined with a climate and land-cover regression equation. Precipitation and streamflow records were compiled for 838 watersheds for 1971-2000 across the U.S. to obtain long-term estimates of actual ET. A regression equation was developed that related the ratio ET/P to climate and land-cover variables within those watersheds. Precipitation and temperatures were used from the PRISM climate dataset, and land-cover data were used from the USGS National Land Cover Dataset. Results indicate that ET can be predicted relatively well at a watershed or county scale with readily available climate variables alone, and that land-cover data can also improve those predictions. Using the climate and land-cover data at an 800-m scale and then averaging to the county scale, maps were produced showing estimates of ET and ET/P for the entire conterminous U.S. Using the regression equation, such maps could also be made for more detailed state coverages, or for other areas of the world where climate and land-cover data are plentiful.

Antifungal Activity of Microbial Secondary Metabolites

PubMed Central

Okoli, Ikechukwu; Mylonakis, Eleftherios

2011-01-01

Secondary metabolites are well known for their ability to impede other microorganisms. Reanalysis of a screen of natural products using the Caenorhabditis elegans-Candida albicans infection model identified twelve microbial secondary metabolites capable of conferring an increase in survival to infected nematodes. In this screen, the two compound treatments conferring the highest survival rates were members of the epipolythiodioxopiperazine (ETP) family of fungal secondary metabolites, acetylgliotoxin and a derivative of hyalodendrin. The abundance of fungal secondary metabolites indentified in this screen prompted further studies investigating the interaction between opportunistic pathogenic fungi and Aspergillus fumigatus, because of the ability of the fungus to produce a plethora of secondary metabolites, including the well studied ETP gliotoxin. We found that cell-free supernatant of A. fumigatus was able to inhibit the growth of Candida albicans through the production of a secreted product. Comparative studies between a wild-type and an A. fumigatus ΔgliP strain unable to synthesize gliotoxin demonstrate that this secondary metabolite is the major factor responsible for the inhibition. Although toxic to organisms, gliotoxin conferred an increase in survival to C. albicans-infected C. elegans in a dose dependent manner. As A. fumigatus produces gliotoxin in vivo, we propose that in addition to being a virulence factor, gliotoxin may also provide an advantage to A. fumigatus when infecting a host that harbors other opportunistic fungi. PMID:21966496

Additional sex combs-like 1 belongs to the enhancer of trithorax and Polycomb Group and genetically interacts with Cbx2 in mice

PubMed Central

Fisher, C.L.; Lee, I.; Bloyer, S.; Bozza, S.; Chevalier, J.; Dahl, A; Bodner, C.; Helgason, C. D.; Hess, J.L.; Humphries, R.K.; Brock, H.W.

2009-01-01

The Additional sex combs (Asx) gene of Drosophila behaves genetically as an enhancer of trithorax and Polycomb (ETP) in displaying bidirectional homeotic phenotypes, suggesting that is required for maintenance of both activation and silencing of Hox genes. There are 3 murine homologs of Asx called Additional sex combs-like1, 2, and-3. Asxl1 is required for normal adult hematopoiesis; however its embryonic function is unknown. We used a targeted mouse mutant line Asxl1tm1Bc to determine if Asxl1 is required to silence and activate Hox genes in mice during axial patterning. The mutant embryos exhibit simultaneous anterior and posterior transformations of the axial skeleton, consistent with a role for Asxl1 in activation and silencing of Hox genes. Transformations of the axial skeleton are enhanced in compound mutant embryos for the Polycomb group gene M33/Cbx2. Hox a4, a7, and c8 are derepressed in Asxl1tm1Bc mutants in the antero-posterior axis, but Hox c8 expression is reduced in the brain of mutants, consistent with Asxl1 being required both for activation and repression of Hox genes. We discuss the genetic and molecular definition of ETPs, and suggest that the function of Asxl1 depends on its cellular context. PMID:19833123

Re-energizing enquiry among our young professionals

NASA Astrophysics Data System (ADS)

Roychoudhuri, ChandraSekhar

2017-08-01

Children are born with enquiring mindset. They keep on asking questions to explore, understand and take part in their environment. However, modern educational systems discourage persistent enquiring questions. Most students, graduating from college, can use their enquiring faculties only to solve problems at hand. They accept the theories taught as the final models for the laws of nature. They safely assume that no further deeper enquiry is needed. This is a disturbing collective tendency counter to our continuously evolving nature. We should also consciously train our minds to evolve continuously by persistently asking enquiring questions. Therefore, we suggest that we take pro-active steps to re-energize the enquiring mindset among our young professionals by organizing enquiry forums for students from all international Student Chapters during most of our optical society meetings. Panels of volunteer senior scientists should encourage deep enquiring questions from the students. In this paper, as examples, I will present a set of enquiring questions in the field of optics that we have been underscoring to students. This is one of the three papers by this author for this conference, ETOP 100-43. Since scientific content-wise they complement each other, the readers should consult the others. They are: ETP100-36, "Consequences of repeated discovery and benign neglect of non-interaction of waves" and ETP100-83, and "Demonstration and implications when 50% beam combiners can behave as 0 or 100% reflector/transmitter inside some interferometers."

Environmental controls of evapotranspiration in a mixed plantation in North China.

PubMed

Tong, Xiaojuan; Zhang, Jinsong; Meng, Ping; Li, Jun; Zheng, Ning

2017-02-01

The mixed plantation plays an important role in the water cycle in the hilly area of North China. To evaluate the effect of afforestation on the water balance in this region, the temporal variation of evapotranspiration (ET) and environmental controls were investigated based on the eddy flux measurement of water vapor in a 31-year-old mixed plantation from 2006 to 2010. During 5 years, annual ET ranged from 513 to 680 mm, with an average of 579 mm. Growing season ET accounted for 72-82 % of annual ET during the 5-year period and its interannual variation was determined by the number of rainy days. In the non-growing and growing seasons, monthly ET was primarily dependent on monthly mean soil water content and monthly mean net radiation, respectively. Annual mean Priestley-Taylor coefficient (α) was 0.64, and the decoupling factor (Ω) was 0.48. High values of α and Ω implied that ET was energy limited in the growing seasons of 2006-2010. The mean annual ratio of ET to precipitation (ET/P) was 1.10. The density of the mixed plantation was around 50 % higher than the optimal value determined by local water capacity, leading to a large ET/P ratio. The dense plantation needs to be thinned to prevent excessive water loss in the hilly area of North China.

The endogenous adrenodoxin reductase-like flavoprotein arh1 supports heterologous cytochrome P450-dependent substrate conversions in Schizosaccharomyces pombe.

PubMed

Ewen, Kerstin M; Schiffler, Burkhard; Uhlmann-Schiffler, Heike; Bernhardt, Rita; Hannemann, Frank

2008-05-01

Mitochondrial cytochromes P450 are essential for biosynthesis of steroid hormones, vitamin D and bile acids. In mammals, the electrons needed for these reactions are provided via adrenodoxin and adrenodoxin reductase (AdR). Recently, Schizosaccharomyces pombe was introduced as a new host for the functional expression of human mitochondrial steroid hydroxylases without the coexpression of their natural redox partners. This fact qualifies S. pombe for the biotechnological production of steroids and for application as inhibitor test organism of heterologously expressed cytochromes P450. In this paper, we present evidence that the S. pombe ferredoxin reductase, arh1, and ferredoxin, etp1fd provide mammalian class I cytochromes P450 with reduction equivalents. The recombinant reductase showed an unusual weak binding of flavin adenine dinucleotide (FAD), which was mastered by modifying the FAD-binding region by site-directed mutagenesis yielding a stable holoprotein. The modified reductase arh1_A18G displayed spectroscopic characteristics similar to AdR and was shown to be capable of accepting electrons with no evident preference for NADH or NADPH, respectively. Arh1_A18G can substitute for AdR by interacting not only with its natural redox partner etp1fd but also with the mammalian homolog adrenodoxin. Cytochrome P450-dependent substrate conversion with all combinations of the mammalian and yeast redox proteins was evaluated in a reconstituted system.

Sorption of phenol and alkylphenols from aqueous solution onto organically modified montmorillonite and applications of dual-mode sorption model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huh, J.K.; Song, D.I.; Jeon, Y.W.

2000-01-01

Single- and multisolute competitive sorptions were carried out in a batch reactor to investigate the uptake of phenol, 4-methylphenol (MeP), 2,4-dimethylphenol (DMeP), and 4-ethylphenol (EtP) dissolved in water at 25 C onto organically modified montmorillonite. Hexadecyltrimethylammonium (HDTMA) cation was exchanged for metal cations on the montmorillonite to the extent of the cation-exchange capacity (CEC) of the montmorillonite to prepare HDTMA-montmorillonite, changing its surface property from hydrophilic to organophilic. It was observed from the experimental results that the adsorption affinity on HDTMA-montmorillonite was in the order 4-EtP {approx} 2,4-DMeP > 4-MeP > phenol. The Langmuir, dual-mode sorption (DS), and Redlich-Peterson (RP)more » models were used to analyze the single-solute sorption equilibria. The competitive Langmuir model (CLM), competitive dual-mode sorption model (CDSM), and ideal adsorbed solution theory (IAST), coupled with the single-solute models (i.e., Langmuir, DS, and RP models), were used to predict the multisolute competitive sorption equilibria. All the models considered in this work yielded favorable representations of both single- and multisolute sorption behaviors. DSM, CDSM, and IAST coupled with the DSM were found to be other satisfactory models to describe the single- and multisolute sorption of the phenolic compounds onto HDTMA-montmorillonite.« less

From the cradle to the grave: activities of GATA-3 throughout T cell development and differentiation

PubMed Central

Hosoya, Tomonori; Maillard, Ivan; Engel, James Douglas

2010-01-01

Summary GATA family transcription factors play multiple vital roles in hematopoiesis in many cell lineages, and in particular, T cells require GATA-3 for execution of several developmental steps. Transcriptional activation of the Gata3 gene is observed throughout T-cell development and differentiation in stage-specific fashion. GATA-3 has been described as a master regulator of T-helper 2 (Th2) cell differentiation in mature CD4+ T cells. During T-cell development in the thymus, its roles in the CD4 vs. CD8 lineage choice and at the β-selection checkpoint are the best characterized. In contrast, its importance prior to β-selection has been obscured both by the developmental heterogeneity of double negative (DN) 1 thymocytes and the paucity of early T-lineage progenitors (ETPs), a subpopulation of DN1 cells that contains the most immature thymic progenitors that retain potent T-lineage developmental potential. By examining multiple lines of in vivo evidence procured through the analysis of Gata3 mutant mice, we have recently demonstrated that GATA-3 is additionally required at the earliest stage of thymopoiesis for the development of the ETP population. Here, we review the characterized functions of GATA-3 at each stage of T-cell development and discuss hypothetical molecular pathways that mediate these functions. PMID:20969588

Species Profiles. Life Histories and Environmental Requirements of Coastal Fishes and Invertebrates (Pacific Northwest). Common Littleneck Clam.

DTIC Science & Technology

1987-08-01

Fishery in coastal communities and is a factor in Washington the economies of some rural areas. Of the annual commercial catch of clams, In Washington...AD-A199 654 SPECIES PROFILES LIFE HISTORIES AND ENVIRONMENTAL / REQUIREMENTS OF COASTAL.. (U) MASHINGTON UNIV SEATTLE SCHOOL OF FISHERIES K K CHEM ET...P. Ma Division of Fishery Science and Aquaculture School of Fisheries University of Washington 0 Seattle, WA 98195 Project Officer David Moran 0

Normal pregnancy is associated with an increase in thrombin generation from the very early stages of the first trimester.

PubMed

Bagot, C N; Leishman, E; Onyiaodike, C C; Jordan, F; Freeman, D J

2017-09-01

Pregnancy is a hypercoagulable state associated with an increased risk of venous thrombosis, which begins during the first trimester, but the exact time of onset is unknown. Thrombin generation, a laboratory marker of thrombosis risk, increases during normal pregnancy but it is unclear exactly how early this increase occurs. We assessed thrombin generation by Calibrated Automated Thrombography in women undergoing natural cycle in vitro fertilization, who subsequently gave birth at term following a normal pregnancy (n=22). Blood samples were taken just prior to conception and repeated five times during very early pregnancy, up to Day 59 estimated gestation. Mean Endogenous Thrombin Potential (ETP), peak thrombin generation and Velocity Index (VI) increased significantly from pre-pregnancy to Day 43 gestation (p=0.024-0.0004). This change persisted to Day 59 gestation. The mean of the percentage change from baseline, accounting for inter-individual variation, in ETP, peak thrombin and VI increased significantly from pre-pregnancy to Day 32 gestation (p=0.0351-<0.0001) with the mean increase from baseline persisting to Day 59 gestation. Thrombin generation increases significantly during the very early stages of normal pregnancy when compared to the pre-pregnancy state. The increased risk of venous thrombosis therefore likely begins very early in a woman's pregnancy, suggesting that women considered clinically to be at high thrombotic risk should start thromboprophylaxis as early as possible after a positive pregnancy test. Copyright © 2017 Elsevier Ltd. All rights reserved.

Additional sex combs interacts with enhancer of zeste and trithorax and modulates levels of trimethylation on histone H3K4 and H3K27 during transcription of hsp70.

PubMed

Li, Taosui; Hodgson, Jacob W; Petruk, Svetlana; Mazo, Alexander; Brock, Hugh W

2017-09-19

Maintenance of cell fate determination requires the Polycomb group for repression; the trithorax group for gene activation; and the enhancer of trithorax and Polycomb (ETP) group for both repression and activation. Additional sex combs (Asx) is a genetically identified ETP for the Hox loci, but the molecular basis of its dual function is unclear. We show that in vitro, Asx binds directly to the SET domains of the histone methyltransferases (HMT) enhancer of zeste [E(z)] (H3K27me3) and Trx (H3K4me3) through a bipartite interaction site separated by 846 amino acid residues. In Drosophila S2 cell nuclei, Asx interacts with E(z) and Trx in vivo. Drosophila Asx is required for repression of heat-shock gene hsp70 and is recruited downstream of the hsp70 promoter. Changes in the levels of H3K4me3 and H3K27me3 downstream of the hsp70 promoter in Asx mutants relative to wild type show that Asx regulates H3K4 and H3K27 trimethylation. We propose that during transcription Asx modulates the ratio of H3K4me3 to H3K27me3 by selectively recruiting the antagonistic HMTs, E(z) and Trx or other nucleosome-modifying enzymes to hsp70.

A User’s Manual for Electromagnetic Surface Patch (ESP) Code. Version II. Polygonal Plates and Wires.

DTIC Science & Technology

1983-09-01

to geometries not large in terms of wavelength and the lack of analytical results which can provide physical insight into the problem. The first...EPTS)*Ŗ) STPM *2. ’TP’ (CABS (ETPS)*Ŗ) STTHi2.*TP*(CARS(ETTS)*Ŗ) RETURN - 1 END 296 do APPENDIX 37 * SUBROUTINE SURFFY SUBROUTINE.SURF!? (KXl,YN1...D-Ai135 837 A USER’S MAiNUAfL FOR ELECTROMAGNETIC SURFACE PATCH (ESP) 1 /4 CODE VERSION 11 P.-(U) OHIO STATE UNIV COLUMBUS U CLAS ELECTROSCIENCE LAB E

Different profile of thrombin generation in children with acute lymphoblastic leukaemia treated with native or pegylated asparaginase: A cohort study.

PubMed

Rozen, Laurence; Noubouossie, Denis; Dedeken, Laurence; Huybrechts, Sophie; Lê, Phu Quoc; Ferster, Alina; Demulder, Anne

2017-02-01

Asparaginase (Asp) and corticosteroid (CS) treatment in patients with acute lymphoblastic leukaemia (ALL) is associated with an increased risk of thrombotic events. Characterization of global haemostatic phenotypes of patients with ALL during Asp therapy. Thrombin generation (TG) was monitored in platelet-poor plasma of 56 children treated for a B lineage ALL (36 with native, 20 with PEG Asp) using 1 pM tissue factor and 4 μM phospholipids, with and without thrombomodulin. Protein C activity (PC), free protein S (PS), antithrombin (AT) and fibrinogen levels were also measured. Elevated endogenous thrombin potential (ETP) and peak of TG were noted at diagnosis, throughout the Induction phase and Late Intensification but was significantly less for PEG than for native Asp (P < 0.001), while age, sex, type of corticosteroid during Induction and molecular response had no significant effect. The reduction of ETP after addition of thrombomodulin was significantly lower in ALL children compared with that in controls, suggesting impairment in PS/PC pathway. Three patients experienced thrombosis: two treated with native and one with PEG Asp. The two patients with native Asp had, at the time of thrombosis, a prothrombotic profile. Treatment with Asp, in combination with CS, enhances TG in children with ALL, more significantly with native than PEG Asp, which is present early at diagnosis, persists during Induction and reappears during Late Intensification. This is consistent with the high incidence of thrombotic events described during these phases of therapy. The less pronounced effect of PEG Asp remains to be elucidated. © 2016 Wiley Periodicals, Inc.

Rapid recovery of a coral dominated Eastern Tropical Pacific reef after experimentally produced anthropogenic disturbance.

PubMed

Muthukrishnan, Ranjan; Fong, Peggy

2018-05-07

Local anthropogenic stressors such as overfishing, nutrient enrichment and increased sediment loading have been shown to push coral reefs toward greater dominance by algae. In a few cases this shift has been temporary, with the ability to recover to a healthy coral-dominated community after disturbance, suggesting some systems have considerable resilience. However, an understanding of the circumstances under which reefs may recover is only beginning to emerge. We monitored recovery of a coral-dominated reef in the Eastern Tropical Pacific (ETP) after cessation of a ∼6 month multiple stressor experiment (with herbivore exclosure, nutrient addition, and sediment addition). We observed substantial recovery from small-scale disturbances, though there were differences in both the extent and temporal dynamics of recovery between treatments. Plots that had been caged showed the largest recovery in absolute terms and recovery was quite rapid, while nutrient and sediment addition plots were slower to recover. We also observed different recovery patterns depending on the type of algae that replaced coral during or after disturbances. Macroalgae that established during manipulation were almost completely removed within 2 weeks, revealing that a significant proportion had covered still-living coral. Turf algae persisted longer, but were almost completely replaced by regenerating coral within 18 months. Very little crustose coralline algae were apparent during manipulations, but coverage did increase during recovery. This rapid recovery of corals after simulated anthropogenic disturbance to ETP reefs underscores the value of management of local stressors for short-term recovery and perhaps as a buffer for longer-term global stressors. Copyright © 2018 Elsevier Ltd. All rights reserved.

Isolation by environment in the highly mobile olive ridley turtle (Lepidochelys olivacea) in the eastern Pacific.

PubMed

Rodríguez-Zárate, Clara J; Sandoval-Castillo, Jonathan; van Sebille, Erik; Keane, Robert G; Rocha-Olivares, Axayácatl; Urteaga, Jose; Beheregaray, Luciano B

2018-05-16

Spatial and temporal scales at which processes modulate genetic diversity over the landscape are usually overlooked, impacting the design of conservation management practices for widely distributed species. We examine processes shaping population divergence in highly mobile species by re-assessing the case of panmixia in the iconic olive ridley turtle from the eastern Pacific. We implemented a biophysical model of connectivity and a seascape genetic analysis based on nuclear DNA variation of 634 samples collected from 27 nesting areas. Two genetically distinct populations largely isolated during reproductive migrations and mating were detected, each composed of multiple nesting sites linked by high connectivity. This pattern was strongly associated with a steep environmental gradient and also influenced by ocean currents. These findings relate to meso-scale features of a dynamic oceanographic interface in the eastern tropical Pacific (ETP) region, a scenario that possibly provides different cost-benefit solutions and selective pressures for sea turtles during both the mating and migration periods. We reject panmixia and propose a new paradigm for olive ridley turtles where reproductive isolation due to assortative mating is linked to its environment. Our study demonstrates the relevance of integrative approaches for assessing the role of environmental gradients and oceanographic currents as drivers of genetic differentiation in widely distributed marine species. This is relevant for the conservation management of species of highly mobile behaviour, and assists the planning and development of large-scale conservation strategies for the threatened olive ridley turtles in the ETP. © 2018 The Author(s).

ENSO-Driven Variability of Denitrification and Suboxia in the Eastern Tropical Pacific Ocean

NASA Astrophysics Data System (ADS)

Yang, Simon; Gruber, Nicolas; Long, Matthew C.; Vogt, Meike

2017-10-01

The Eastern Tropical Pacific (ETP) hosts two of the world's three Oxygen Deficient Zones (ODZs), large bodies of suboxic water that are subject to high rates of water column denitrification (WCD). In the mean, these two ODZs are responsible for about 15 to 40% of all fixed N loss in the ocean, but little is known about how this loss varies in time. Here we use a hindcast simulation with the ocean component of the National Center for Atmospheric Research (NCAR) Community Earth System Model over the period 1948 to 2009 to show that the El Niño-Southern Oscillation (ENSO) drives large variations in the rates of WCD in this region. During mature La Niña (El Niño) conditions, peak denitrification rates are up to 70% higher (lower) than the mean rates. This large variability is the result of wind-driven changes in circulation and isopycnal structure concurrently modifying the thermocline distribution of O2 and organic matter export in such a way that the response of WCD is strongly amplified. During average La Niña (El Niño) conditions, the overall changes in ODZ structure and primarily the shoaling (deepening) of the upper boundary of both ODZs by 40 to 100 m explains 50% of the changes in WCD in the North Pacific and 94% in the South Pacific. Such a large variability of WCD in the ETP has strong implications for the assessments of trends, the balance of the marine N cycle and the emission of the greenhouse gas N2O.

An Inexpensive Real-Time Interactive Three Dimensional Flight Simulation System.

DTIC Science & Technology

1987-06-01

irh ’.etp. the 4i, n. he Ii~ Pi~op 4’ WV o cl d m od 0 V d 0 i c IV 1 M A,.. wq li . .. . . . " VII. TARGET INTEGRATION A. GENERAL The primary ...kts 200 kts Direction 359.9 degrees 0 degrees From prelaunch 99 5* 0 0 4 5 @ G 2 3 00 ALT 01 Figure 9.6 IRIS Dial Box Fuctions 100 summary box for a...Description: The primary purpose of get tgt pos is to move the targets in the simulation. If the networking capability is in lise, the target positions for

Anaerobic-aerobic treatment of purified terephthalic acid (PTA) effluent; a techno-economic alternative to two-stage aerobic process.

PubMed

Pophali, G R; Khan, R; Dhodapkar, R S; Nandy, T; Devotta, S

2007-12-01

This paper addresses the treatment of purified terephthalic acid (PTA) effluent using anaerobic and aerobic processes. Laboratory studies were carried out on flow proportionate composite wastewater generated from the manufacturing of PTA. An activated sludge process (ASP-two stage and single stage) and an upflow anaerobic fixed film fixed bed reactor (AFFFBR) were used, individually and in combination. The performance of a full-scale ETP under existing operating conditions was also studied. Full scale ETP studies revealed that the treatment of PTA effluent using a two-stage ASP alone does not meet treated effluent quality within the prescribed Indian Standards. The biomass produced in the two stage ASP was very viscous and fluffy and the sludge volume index (SVI) was very high (200-450 ml/g). However, pretreatment of PTA effluent using an upflow AFFFBR ensured substantial reduction in BOD (63%) and COD (62%) with recovery of biogas at 1.8-1.96 l/l effluent treated at a volumetric loading rate (VLR) 4-5 kg COD/m(3) d. The methane content in the biogas varied between 55% and 60%. The pretreated effluent from the upflow AFFFBR was then treated through a single stage ASP. The biomass produced in the ASP after anaerobic treatment had very good settlability (SVI: 75-90 ml/g) as compared to the two stage ASP and the treated effluent quality with respect to BOD, COD and SS was within the prescribed Indian Standards. The alternative treatment process comprising an upflow AFFFBR and a single stage ASP ensured net power saving of 257 kW and in addition generated 442 kW of power through the AFFFBR.

Selective inactivation of glutaredoxin by sporidesmin and other epidithiopiperazinediones.

PubMed

Srinivasan, Usha; Bala, Aveenash; Jao, Shu-chuan; Starke, David W; Jordan, T William; Mieyal, John J

2006-07-25

Glutaredoxin (thioltransferase) is a thiol-disulfide oxidoreductase that displays efficient and specific catalysis of protein-SSG deglutathionylation and is thereby implicated in homeostatic regulation of the thiol-disulfide status of cellular proteins. Sporidesmin is an epidithiopiperazine-2,5-dione (ETP) fungal toxin that disrupts cellular functions likely via oxidative alteration of cysteine residues on key proteins. In the current study sporidesmin inactivated human glutaredoxin in a time- and concentration-dependent manner. Under comparable conditions other thiol-disulfide oxidoreductase enzymes, glutathione reductase, thioredoxin, and thioredoxin reductase, were unaffected by sporidesmin. Inactivation of glutaredoxin required the reduced (dithiol) form of the enzyme, the oxidized (intramolecular disulfide) form of sporidesmin, and molecular oxygen. The inactivated glutaredoxin could be reactivated by dithiothreitol only in the presence of urea, followed by removal of the denaturant, indicating that inactivation of the enzyme involves a conformationally inaccessible disulfide bond(s). Various cysteine-to-serine mutants of glutaredoxin were resistant to inactivation by sporidesmin, suggesting that the inactivation reaction specifically involves at least two of the five cysteine residues in human glutaredoxin. The relative ability of various epidithiopiperazine-2,5-diones to inactivate glutaredoxin indicated that at least one phenyl substituent was required in addition to the epidithiodioxopiperazine moiety for inhibitory activity. Mass spectrometry of the modified protein is consistent with formation of intermolecular disulfides, containing one adducted toxin per glutaredoxin but with elimination of two sulfur atoms from the detected product. We suggest that the initial reaction is between the toxin sulfurs and cysteine 22 in the glutaredoxin active site. This study implicates selective modification of sulfhydryls of target proteins in some of the cytotoxic effects of the ETP fungal toxins and their synthetic analogues.

Climate-forced variability of suboxia and associated N-loses in the Pacific Ocean

NASA Astrophysics Data System (ADS)

Yang, S.; Gruber, N.; Long, M. C.; Vogt, M.

2017-12-01

The Eastern Tropical Pacific (ETP) hosts two of the world's three Oxygen Deficient Zones (ODZs), large bodies of suboxic water that are subject to high rates of water column denitrification. In the mean, these two ODZs are responsible for about 15 to 40% of all fixed N loss in the ocean, but little is known about how this loss varies in time. Here, we use a hindcast simulation with the ocean component of the NCAR Community Earth System Model over the period 1960 to 2009 to show that Pacific ODZ structures and their associated rates of N-loss are subject to strong climate forced variability and change. In particular, El Niño-Southern Oscillation (ENSO) drives large interannual variations in the rate of water column denitrification such that mature La Niña conditions exhibit peak denitrification rates that are up to 70% higher than the mean rates, and vice versa during El Niños. At the same time, we simulate large decadal trends in the rate of Pacific N-loss, which decreases by 10 Tg y-1 from the 1960s to the 1980s and subsequently increases by 30 Tg y-1 towards 2009. We demonstrate that this large variability is the result of wind-driven changes in circulation and isopycnal structure concurrently modifying the thermocline distribution of O2 and organic matter export. Finally, we show that the decadal trends in denitrification are recorded by the isotopic signature of particulate organic nitrogen in the ETP but that the interpretation of the signals is non trivial, reflecting both physical and biogeochemical changes as well as contamination by atmospheric pollutants.

Combined Effects of Irrigation Regime, Genotype, and Harvest Stage Determine Tomato Fruit Quality and Aptitude for Processing into Puree.

PubMed

Arbex de Castro Vilas Boas, Alexandre; Page, David; Giovinazzo, Robert; Bertin, Nadia; Fanciullino, Anne-Laure

2017-01-01

Industry tomatoes are produced under a range of climatic conditions and practices which significantly impact on main quality traits of harvested fruits. However, the quality of tomato intended for processing is currently addressed on delivery through color and Brix only, whereas other traits are overlooked. Very few works provided an integrated view of the management of tomato puree quality throughout the chain. To gain insights into pre- and post-harvest interactions, four genotypes, two water regimes, three maturity stages, and two processes were investigated. Field and glasshouse experiments were conducted near Avignon, France, from May to August 2016. Two irrigation regimes were applied: control plants were irrigated in order to match 100% of evapotranspiration (ETP); water deficit (WD) plants were irrigated as control plants until anthesis of the first flowers, then irrigation was reduced to 60 and 50% ETP in field, and glasshouse respectively. Fruits were collected at three stages during ripening. Their color, fresh weight, dry matter content, and metabolite contents were determined before processing. Pericarp cell size was evaluated in glasshouse only. Two laboratory-scaled processing methods were applied before structural and biochemical analyses of the purees. Results outlined interactive effects between crop and process management. WD hardly reduced yield, but increased dry matter content in the field, in contrast to the glasshouse. The puree viscosity strongly depended on the genotype and the maturity stage, but it was disconnected from fruit dry matter content or Brix. The process impact on puree viscosity strongly depended on water supply during fruit production. Moreover, the lycopene content of fresh fruit may influence puree viscosity. This work opens new perspectives for managing puree quality in the field showing that it was possible to reduce water supply without affecting yield and to improve puree quality.

DNA Methylation Adds Prognostic Value to Minimal Residual Disease Status in Pediatric T-Cell Acute Lymphoblastic Leukemia.

PubMed

Borssén, Magnus; Haider, Zahra; Landfors, Mattias; Norén-Nyström, Ulrika; Schmiegelow, Kjeld; Åsberg, Ann E; Kanerva, Jukka; Madsen, Hans O; Marquart, Hanne; Heyman, Mats; Hultdin, Magnus; Roos, Göran; Forestier, Erik; Degerman, Sofie

2016-07-01

Despite increased knowledge about genetic aberrations in pediatric T-cell acute lymphoblastic leukemia (T-ALL), no clinically feasible treatment-stratifying marker exists at diagnosis. Instead patients are enrolled in intensive induction therapies with substantial side effects. In modern protocols, therapy response is monitored by minimal residual disease (MRD) analysis and used for postinduction risk group stratification. DNA methylation profiling is a candidate for subtype discrimination at diagnosis and we investigated its role as a prognostic marker in pediatric T-ALL. Sixty-five diagnostic T-ALL samples from Nordic pediatric patients treated according to the Nordic Society of Pediatric Hematology and Oncology ALL 2008 (NOPHO ALL 2008) protocol were analyzed by HumMeth450K genome wide DNA methylation arrays. Methylation status was analyzed in relation to clinical data and early T-cell precursor (ETP) phenotype. Two distinct CpG island methylator phenotype (CIMP) groups were identified. Patients with a CIMP-negative profile had an inferior response to treatment compared to CIMP-positive patients (3-year cumulative incidence of relapse (CIR3y ) rate: 29% vs. 6%, P = 0.01). Most importantly, CIMP classification at diagnosis allowed subgrouping of high-risk T-ALL patients (MRD ≥0.1% at day 29) into two groups with significant differences in outcome (CIR3y rates: CIMP negative 50% vs. CIMP positive 12%; P = 0.02). These groups did not differ regarding ETP phenotype, but the CIMP-negative group was younger (P = 0.02) and had higher white blood cell count at diagnosis (P = 0.004) compared with the CIMP-positive group. CIMP classification at diagnosis in combination with MRD during induction therapy is a strong candidate for further risk classification and could confer important information in treatment decision making. © 2016 Wiley Periodicals, Inc.

Concizumab, an anti-tissue factor pathway inhibitor antibody, induces increased thrombin generation in plasma from haemophilia patients and healthy subjects measured by the thrombin generation assay.

PubMed

Waters, E K; Sigh, J; Friedrich, U; Hilden, I; Sørensen, B B

2017-09-01

Concizumab, a humanized monoclonal antibody against tissue factor pathway inhibitor (TFPI), is being developed as a subcutaneously (s.c.) administered treatment for haemophilia. It demonstrated a concentration-dependent procoagulant effect in functional TFPI assays; however, global haemostatic assays, such as the thrombin generation assay (TGA), offer a more complete picture of coagulation. We investigated how concizumab affects thrombin generation following ex vivo spiking in plasma from haemophilia patients using the TGA, and if the assay can detect the effect of multiple s.c. concizumab doses in healthy subjects. For the ex vivo spiking study, platelet-poor plasma (PPP) from 18 patients with severe haemophilia was spiked with 0.001-500 nm concizumab. For the multiple-dosing study, four healthy males received concizumab 250 μg kg -1 s.c. every other day for eight doses; blood was collected before and after dosing and processed into PPP. In both studies, thrombin generation was measured using a Calibrated Automated Thrombogram ® system with 1 pm tissue factor. In spiked samples from haemophilia patients, peak thrombin and endogenous thrombin potential (ETP) increased concentration dependently, reaching near-normal levels at concizumab concentrations >10 nm. Repeated s.c. doses of concizumab in healthy subjects increased both peak thrombin and ETP; these effects were sustained throughout the dosing interval. Thrombin generation assay demonstrated increased thrombin generation with concizumab after ex vivo spiking of haemophilia plasma and multiple s.c. doses in healthy subjects, supporting both the utility of the TGA in evaluating concizumab treatment and the potential of s.c. concizumab as a novel haemophilia therapy. © 2017 The Authors. Haemophilia Published by John Wiley & Sons Ltd.

Antibodies derived from an enterotoxigenic Escherichia coli (ETEC) adhesin tip MEFA (multiepitope fusion antigen) against adherence of nine ETEC adhesins: CFA/I, CS1, CS2, CS3, CS4, CS5, CS6, CS21 and EtpA.

PubMed

Nandre, Rahul M; Ruan, Xiaosai; Duan, Qiangde; Sack, David A; Zhang, Weiping

2016-06-30

Diarrhea continues to be a leading cause of death in children younger than 5 years in developing countries. Enterotoxigenic Escherichia coli (ETEC) is a leading bacterial cause of children's diarrhea and travelers' diarrhea. ETEC bacteria initiate diarrheal disease by attaching to host receptors at epithelial cells and colonizing in small intestine. Therefore, preventing ETEC attachment has been considered the first line of defense against ETEC diarrhea. However, developing vaccines effectively against ETEC bacterial attachment encounters challenge because ETEC strains produce over 23 immunologically heterogeneous adhesins. In this study, we applied MEFA (multiepitope fusion antigen) approach to integrate epitopes from adhesin tips or adhesive subunits of CFA/I, CS1, CS2, CS3, CS4, CS5, CS6, CS21 and EtpA adhesins and to construct an adhesin tip MEFA peptide. We then examined immunogenicity of this tip MEFA in mouse immunization, and assessed potential application of this tip MEFA for ETEC vaccine development. Data showed that mice intraperitoneally immunized with this adhesin tip MEFA developed IgG antibody responses to all nine ETEC adhesins. Moreover, ETEC and E. coli bacteria expressing these nine adhesins, after incubation with serum of the immunized mice, exhibited significant reduction in attachment to Caco-2 cells. These results indicated that anti-adhesin antibodies induced by this adhesin tip MEFA blocked adherence of the most important ETEC adhesins, suggesting this multivalent tip MEFA may be useful for developing a broadly protective anti-adhesin vaccine against ETEC diarrhea. Copyright © 2016 Elsevier Ltd. All rights reserved.

In vitro comparison of the effect of two factor XI (FXI) concentrates on thrombin generation in major FXI deficiency.

PubMed

Pike, G N; Cumming, A M; Hay, C R M; Sempasa, B; Sutherland, M; Thachil, J; Burthem, J; Bolton-Maggs, P H B

2016-05-01

Bleeding risk in factor XI (FXI) deficiency following surgery may be reduced by treatment with either of two FXI concentrates, but indications for their use are unclear and treatment has been associated with thrombosis. To quantify and compare the effects of two different FXI concentrates on thrombin generation (TG) in major FXI deficiency (FXI:C < 15 IU dL(-1) ). Thrombin generation was measured in controls (n = 50), FXI-deficient individuals pre and post in vitro spiking with FXI concentrates (n = 10), and in ex vivo samples following treatment with FXI concentrate (n = 3). Thrombin generation was significantly impaired in FXI deficiency but improved following FXI replacement in vitro and in vivo. LFB Hemoleven(®) had greater effect on TG than BPL FXI concentrate in vitro (equivalent in vivo doses 10, 20 and 30 U kg(-1) ): higher endogenous thrombin potential (ETP) (P < 0.0001), peak height (P < 0.01) velocity (P < 0.0002) and shorter lag time and time to peak (both P < 0.003). Some measurements with LFB Hemoleven(®) exceeded the reference range. At lower dose (5 U kg(-1) ), BPL FXI concentrate normalized all TG parameters and LFB Hemoleven(®) normalized the ETP but exceeded the reference range with other parameters. Both FXI concentrates improve TG in vitro in major FXI deficiency but differ in dose response, and for both products, doses lower than previously recommended normalized TG in vitro. Comparison of in vitro spiked and ex vivo samples suggest that in vitro results could be used to estimate an expected in vivo response to FXI replacement. © 2015 John Wiley & Sons Ltd.

Estimation of Some Bio-Physical Indicators for Sustainable Crop Production in the Eastern Nile Basin of Sudan Using Landsat-8 Imagery and SEBAL Model

NASA Astrophysics Data System (ADS)

Guma Biro Turk, Khalid

2016-07-01

Crop production under modern irrigation systems require unique management at field level and hence better utilization of agricultural inputs and water resources. This study aims to make use of remote sensing (RS) data and the surface energy balance algorithm for land (SEBAL) to improve the on-farm management. The study area is located in the Eastern part of the Blue Nile River about 60 km south of Khartoum, Sudan. Landsat-8 data were used to estimate a number of bio-physical indicators during the growing season of the year 2014/2015. Accordingly, in-situ weather data and SEBAL model were applied to calculate: the reference (ET0), actual (ETa) and potential (ETp) evapotranspiration, soil moisture (SM), crop factor (kc), nitrogen (N), biomass production (BP) and crop water productivity (CWP). Results revealed that ET0 showed steady variation throughout the year, varying from 5 to 7 mm/day. However, ETa and ETp showed clear temporal variation attributed to frequent cutting of the alfalfa, almost monthly. The BP of the alfalfa was observed to be high when there is no cutting activates were made before the image acquisition date. Nevertheless the CWP trends are following the biomass production ones, low when there is no biomass and high when the biomass is high. The application of SEBAL model within the study area using the Landsat-8 imagery indicates that it's possible to produce field-based bio-physical indicators, which can be useful in monitoring and managing the field during the growing season. However, a cross-calibration with the in-situ data should be considered in order to maintain the spatial variability within the field. Keywords: Bio-physical Indicators; Remote Sensing; SEBAL; Landsat-8; Eastern Nile Basin

Sorbitol-Fermenting Enterohemorrhagic Escherichia coli O157:H− Isolates from Czech Patients with Novel Plasmid Composition Not Previously Seen in German Isolates

PubMed Central

Bauwens, Andreas; Marejková, Monika; Middendorf-Bauchart, Barbara; Prager, Rita; Kossow, Annelene; Zhang, Wenlan; Karch, Helge

2017-01-01

ABSTRACT Sorbitol-fermenting (SF) enterohemorrhagic Escherichia coli (EHEC) O157:H− strains, first identified in Germany, have emerged as important pathogens throughout Europe. Besides chromosomally encoded Shiga toxin 2a (the major virulence factor), several putative virulence loci, including the hly, etp, and sfp operons, encoding EHEC hemolysin, type II secretion system proteins, and Sfp fimbriae, respectively, are located on the 121-kb plasmid pSFO157 in German strains. Here we report novel SF EHEC O157:H− strains isolated from patients in the Czech Republic. These strains share the core genomes and chromosomal virulence loci encoding toxins (stx2a and the cdtV-ABC operon) and adhesins (eae-γ, efa1, lpfAO157OI-141, and lpfAO157OI-154) with German strains but differ essentially in their plasmids. In contrast to all previously detected SF EHEC O157:H− strains, the Czech strains carry two plasmids, of 79 kb and 86 kb. The 79-kb plasmid harbors the sfp operon, but neither of the plasmids contains the hly and etp operons. Sequence analyses demonstrated that the 79-kb plasmid (pSFO157 258/98-1) evolved from pSFO157 of German strains by deletion of a 41,534-bp region via homologous recombination, resulting in loss of the hly and etp operons. The 86-kb plasmid (pSFO157 258/98-2) displays 98% sequence similarity to a 92.7-kb plasmid of an extraintestinal pathogenic E. coli bloodstream isolate. Our finding of this novel plasmid composition in SF EHEC O157:H− strains extends the evolutionary history of EHEC O157 plasmids. Moreover, the unique molecular plasmid characteristics permit the identification of such strains, thereby facilitating further investigations of their geographic distribution, clinical significance, and epidemiology. IMPORTANCE Since their first identification in Germany in 1989, sorbitol-fermenting enterohemorrhagic Escherichia coli O157:H− (nonmotile) strains have emerged as important causes of the life-threatening disease hemolytic-uremic syndrome in Europe. They account for 10 to 20% of sporadic cases of this disease and have caused several large outbreaks. The strains isolated throughout Europe share conserved chromosomal and plasmid characteristics. Here we identified novel sorbitol-fermenting enterohemorrhagic E. coli O157:H− patient isolates in the Czech Republic which differ from all such strains reported previously by their unique plasmid characteristics, including plasmid number, composition of plasmid-carried virulence genes, and plasmid origins. Our findings contribute substantially to understanding the evolution of E. coli O157 strains and their plasmids. In practical terms, they enable the identification of strains with these novel plasmid characteristics in patient stool samples and thus the investigation of their roles as human pathogens in other geographic areas. PMID:28970221

Sorbitol-Fermenting Enterohemorrhagic Escherichia coli O157:H- Isolates from Czech Patients with Novel Plasmid Composition Not Previously Seen in German Isolates.

PubMed

Bauwens, Andreas; Marejková, Monika; Middendorf-Bauchart, Barbara; Prager, Rita; Kossow, Annelene; Zhang, Wenlan; Karch, Helge; Mellmann, Alexander; Bielaszewska, Martina

2017-12-01

Sorbitol-fermenting (SF) enterohemorrhagic Escherichia coli (EHEC) O157:H - strains, first identified in Germany, have emerged as important pathogens throughout Europe. Besides chromosomally encoded Shiga toxin 2a (the major virulence factor), several putative virulence loci, including the hly , etp , and sfp operons, encoding EHEC hemolysin, type II secretion system proteins, and Sfp fimbriae, respectively, are located on the 121-kb plasmid pSFO157 in German strains. Here we report novel SF EHEC O157:H - strains isolated from patients in the Czech Republic. These strains share the core genomes and chromosomal virulence loci encoding toxins ( stx 2a and the cdtV -ABC operon) and adhesins ( eae -γ, efa1 , lpfA O157OI-141 , and lpfA O157OI-154 ) with German strains but differ essentially in their plasmids. In contrast to all previously detected SF EHEC O157:H - strains, the Czech strains carry two plasmids, of 79 kb and 86 kb. The 79-kb plasmid harbors the sfp operon, but neither of the plasmids contains the hly and etp operons. Sequence analyses demonstrated that the 79-kb plasmid (pSFO157 258/98-1) evolved from pSFO157 of German strains by deletion of a 41,534-bp region via homologous recombination, resulting in loss of the hly and etp operons. The 86-kb plasmid (pSFO157 258/98-2) displays 98% sequence similarity to a 92.7-kb plasmid of an extraintestinal pathogenic E. coli bloodstream isolate. Our finding of this novel plasmid composition in SF EHEC O157:H - strains extends the evolutionary history of EHEC O157 plasmids. Moreover, the unique molecular plasmid characteristics permit the identification of such strains, thereby facilitating further investigations of their geographic distribution, clinical significance, and epidemiology. IMPORTANCE Since their first identification in Germany in 1989, sorbitol-fermenting enterohemorrhagic Escherichia coli O157:H - (nonmotile) strains have emerged as important causes of the life-threatening disease hemolytic-uremic syndrome in Europe. They account for 10 to 20% of sporadic cases of this disease and have caused several large outbreaks. The strains isolated throughout Europe share conserved chromosomal and plasmid characteristics. Here we identified novel sorbitol-fermenting enterohemorrhagic E. coli O157:H - patient isolates in the Czech Republic which differ from all such strains reported previously by their unique plasmid characteristics, including plasmid number, composition of plasmid-carried virulence genes, and plasmid origins. Our findings contribute substantially to understanding the evolution of E. coli O157 strains and their plasmids. In practical terms, they enable the identification of strains with these novel plasmid characteristics in patient stool samples and thus the investigation of their roles as human pathogens in other geographic areas. Copyright © 2017 American Society for Microbiology.

Stratégie de prise en charge de l'hypertension artérielle en hémodialyse chronique: un modèle appliqué d’éducation thérapeutique des patients (ETP)

PubMed Central

El Harraqui, Ryme; Naima, Abda; Yassamine, Bentata; Haddiya, Intissar

2014-01-01

Même après l'entrée en dialyse, la prévalence de l'hypertension artérielle (HTA) reste élevée. Elle est souvent greffée d'une forte morbi-mortalité, et altère la qualité de vie des patients hémodialysés chroniques. La « méthode du poids sec (PS) », établie par Scribner, présente un intérêt indéniable dans la gestion de l'HTA chez le patient hémodialysé. Le but de notre travail était de déterminer la prévalence et les facteurs de risque (FDR) de l'HTA chez nos hémodialysés chroniques et d'en tenter une réduction en nous basant sur une stratégie d’éducation thérapeutique basée sur les recommandations de Scribner. Nous avons mené une étude prospective interventionnelle en trois mois et en trois phases, auprès des 93 hémodialysés chroniques de l'Hôpital Al Farabi d'Oujda. En phase 1, nous avons déterminé la prévalence de l'HTA par la surveillance horaire de la tension artérielle (TA) durant la séance de dialyse pendant deux semaines, soit sur un total de 442 séances. Les patients ont également mesuré leur pression artérielle (PA) hors-centre de façon biquotidienne les jours de non-dialyse, soit un total de 1720 mesures hors-centre. L'HTA a été définie par une Pression Artérielle Systolique (PAS) supérieure ou égale à 140mmHg et/ou une Pression Artérielle Diastolique (PAD) supérieure ou égale à 90mmHg sur au moins 2 mesures. En phase 2, les patients hypertendus ont bénéficié d'une prise en charge basée sur les recommandations de Scribner et une éducation thérapeutique (ETP). En phase 3, nous évalué les retombées de notre prise en charge. Une HTA a été notée sur 231 séances chez 57 patients, soit une prévalence de 61,3%. La PAS moyenne était de 172,75±17,69 (145-220) mmHg. Les FDR retenus sont: l’âge, la PPID importante, le non respect des règles hygiéno-diététiques (RHD) et le rythme de 2 séances de dialyse/semaine. Au départ, 13 patients (22,8%) étaient dialysés trois fois par semaine; nous avons doublé ce taux. Nous avons également réduit le PS chez 48 patients, à raison de ½Kg tous les 15 jours. Les résultats en phase 3 montrent que 8 patients sont passés dans le groupe des patients «normotendus », la prévalence de l'HTA passant ainsi à 52,7%. Dans le nouveau groupe «HTA + » (n = 49), la PAS moyenne est passée à 166,12±17,05 (140-200) mmHg. La PPID a baissé de 0,98±0,425 (0,35-2,1) Kgs chez 46 patients. La prévalence de l'HTA dans notre population rejoint les données de la littérature, mais en appliquant les principes de l'ETP à la prise en charge de celle-ci, nous avons pu en baisser la prévalence. Ainsi, La « méthode du PS » peut permettre de corriger l'HTA en HD, mais ce succès ne doit se concevoir sans un effort pédagogique soutenu de la part de l'ensemble de l’équipe soignante, d'où l'intérêt de planifier une ETP PMID:25722759

Combined Effects of Irrigation Regime, Genotype, and Harvest Stage Determine Tomato Fruit Quality and Aptitude for Processing into Puree

PubMed Central

Arbex de Castro Vilas Boas, Alexandre; Page, David; Giovinazzo, Robert; Bertin, Nadia; Fanciullino, Anne-Laure

2017-01-01

Industry tomatoes are produced under a range of climatic conditions and practices which significantly impact on main quality traits of harvested fruits. However, the quality of tomato intended for processing is currently addressed on delivery through color and Brix only, whereas other traits are overlooked. Very few works provided an integrated view of the management of tomato puree quality throughout the chain. To gain insights into pre- and post-harvest interactions, four genotypes, two water regimes, three maturity stages, and two processes were investigated. Field and glasshouse experiments were conducted near Avignon, France, from May to August 2016. Two irrigation regimes were applied: control plants were irrigated in order to match 100% of evapotranspiration (ETP); water deficit (WD) plants were irrigated as control plants until anthesis of the first flowers, then irrigation was reduced to 60 and 50% ETP in field, and glasshouse respectively. Fruits were collected at three stages during ripening. Their color, fresh weight, dry matter content, and metabolite contents were determined before processing. Pericarp cell size was evaluated in glasshouse only. Two laboratory-scaled processing methods were applied before structural and biochemical analyses of the purees. Results outlined interactive effects between crop and process management. WD hardly reduced yield, but increased dry matter content in the field, in contrast to the glasshouse. The puree viscosity strongly depended on the genotype and the maturity stage, but it was disconnected from fruit dry matter content or Brix. The process impact on puree viscosity strongly depended on water supply during fruit production. Moreover, the lycopene content of fresh fruit may influence puree viscosity. This work opens new perspectives for managing puree quality in the field showing that it was possible to reduce water supply without affecting yield and to improve puree quality. PMID:29051767

El Nino-Southern Oscillation Correlated Aerosol Angstrom Exponent Anomaly Over the Tropical Pacific Discovered in Satellite Measurements

NASA Technical Reports Server (NTRS)

Li, Jing; Carlson, Barbara E.; Lacis, Andrew A.

2011-01-01

El Nino.Southern Oscillation (ENSO) is the dominant mode of interannual variability in the tropical atmosphere. ENSO could potentially impact local and global aerosol properties through atmospheric circulation anomalies and teleconnections. By analyzing aerosol properties, including aerosol optical depth (AOD) and Angstrom exponent (AE; often used as a qualitative indicator of aerosol particle size) from the Moderate Resolution Imaging Spectrometer, the Multiangle Imaging Spectroradiometer and the Sea ]viewing Wide Field ]of ]view Sensor for the period 2000.2011, we find a strong correlation between the AE data and the multivariate ENSO index (MEI) over the tropical Pacific. Over the western tropical Pacific (WTP), AE increases during El Nino events and decreases during La Nina events, while the opposite is true over the eastern tropical Pacific (ETP). The difference between AE anomalies in the WTP and ETP has a higher correlation coefficient (>0.7) with the MEI than the individual time series and could be considered another type of ENSO index. As no significant ENSO correlation is found in AOD over the same region, the change in AE (and hence aerosol size) is likely to be associated with aerosol composition changes due to anomalous meteorological conditions induced by the ENSO. Several physical parameters or mechanisms that might be responsible for the correlation are discussed. Preliminary analysis indicates surface wind anomaly might be the major contributor, as it reduces sea ]salt production and aerosol transport during El Nino events. Precipitation and cloud fraction are also found to be correlated with tropical Pacific AE. Possible mechanisms, including wet removal and cloud shielding effects, are considered. Variations in relative humidity, tropospheric ozone concentration, and ocean color during El Nino have been ruled out. Further investigation is needed to fully understand this AE ]ENSO covariability and the underlying physical processes responsible for it.

El Niño-Southern Oscillation correlated aerosol Ångström exponent anomaly over the tropical Pacific discovered in satellite measurements

NASA Astrophysics Data System (ADS)

Li, Jing; Carlson, Barbara E.; Lacis, Andrew A.

2011-10-01

El Niño-Southern Oscillation (ENSO) is the dominant mode of interannual variability in the tropical atmosphere. ENSO could potentially impact local and global aerosol properties through atmospheric circulation anomalies and teleconnections. By analyzing aerosol properties, including aerosol optical depth (AOD) and Ångström exponent (AE; often used as a qualitative indicator of aerosol particle size) from the Moderate Resolution Imaging Spectrometer, the Multiangle Imaging Spectroradiometer and the Sea-viewing Wide Field-of-view Sensor for the period 2000-2011, we find a strong correlation between the AE data and the multivariate ENSO index (MEI) over the tropical Pacific. Over the western tropical Pacific (WTP), AE increases during El Niño events and decreases during La Niña events, while the opposite is true over the eastern tropical Pacific (ETP). The difference between AE anomalies in the WTP and ETP has a higher correlation coefficient (>0.7) with the MEI than the individual time series and could be considered another type of ENSO index. As no significant ENSO correlation is found in AOD over the same region, the change in AE (and hence aerosol size) is likely to be associated with aerosol composition changes due to anomalous meteorological conditions induced by the ENSO. Several physical parameters or mechanisms that might be responsible for the correlation are discussed. Preliminary analysis indicates surface wind anomaly might be the major contributor, as it reduces sea-salt production and aerosol transport during El Niño events. Precipitation and cloud fraction are also found to be correlated with tropical Pacific AE. Possible mechanisms, including wet removal and cloud shielding effects, are considered. Variations in relative humidity, tropospheric ozone concentration, and ocean color during El Niño have been ruled out. Further investigation is needed to fully understand this AE-ENSO covariability and the underlying physical processes responsible for it.

EZH2 mutations and promoter hypermethylation in childhood acute lymphoblastic leukemia.

PubMed

Schäfer, Vivien; Ernst, Jana; Rinke, Jenny; Winkelmann, Nils; Beck, James F; Hochhaus, Andreas; Gruhn, Bernd; Ernst, Thomas

2016-07-01

Acute lymphoblastic leukemia (ALL) is the most common malignancy in children and young adults. The polycomb repressive complex 2 (PRC2) has been identified as one of the most frequently mutated epigenetic protein complexes in hematologic cancers. PRC2 acts as an epigenetic repressor through histone H3 lysine 27 trimethylation (H3K27me3), catalyzed by the histone methyltransferase enhancer of zeste homolog 2 protein (EZH2). To study the prevalence and clinical impact of PRC2 aberrations in an unselected childhood ALL cohort (n = 152), we performed PRC2 mutational screenings by Sanger sequencing and promoter methylation analyses by quantitative pyrosequencing for the three PRC2 core component genes EZH2, suppressor of zeste 12 (SUZ12), and embryonic ectoderm development (EED). Targeted deep next-generation sequencing of 30 frequently mutated genes in leukemia was performed to search for cooperating mutations in patients harboring PRC2 aberrations. Finally, the functional consequence of EZH2 promoter hypermethylation on H3K27me3 was studied by Western blot analyses of primary cells. Loss-of-function EZH2 mutations were detected in 2/152 (1.3 %) patients with common-ALL and early T-cell precursor (ETP)-ALL, respectively. In one patient, targeted deep sequencing identified cooperating mutations in ASXL1 and TET2. EZH2 promoter hypermethylation was found in one patient with ETP-ALL which led to reduced H3K27me3. In comparison with healthy children, the EZH2 promoter was significantly higher methylated in T-ALL patients. No mutations or promoter methylation changes were identified for SUZ12 or EED genes, respectively. Although PRC2 aberrations seem to be rare in childhood ALL, our findings indicate that EZH2 aberrations might contribute to the disease in specific cases. Hereby, EZH2 promoter hypermethylation might have functionally similar consequences as loss-of-function mutations.

Testing the genetic predictions of a biogeographical model in a dominant endemic Eastern Pacific coral (Porites panamensis) using a genetic seascape approach

PubMed Central

Saavedra-Sotelo, Nancy C; Calderon-Aguilera, Luis E; Reyes-Bonilla, Héctor; Paz-García, David A; López-Pérez, Ramón A; Cupul-Magaña, Amilcar; Cruz-Barraza, José A; Rocha-Olivares, Axayácatl

2013-01-01

The coral fauna of the Eastern Tropical Pacific (ETP) is depauperate and peripheral; hence, it has drawn attention to the factors allowing its survival. Here, we use a genetic seascape approach and ecological niche modeling to unravel the environmental factors correlating with the genetic variation of Porites panamensis, a hermatypic coral endemic to the ETP. Specifically, we test if levels of diversity and connectivity are higher among abundant than among depauperate populations, as expected by a geographically relaxed version of the Abundant Center Hypothesis (rel-ACH). Unlike the original ACH, referring to a geographical center of distribution of maximal abundance, the rel-ACH refers only to a center of maximum abundance, irrespective of its geographic position. The patterns of relative abundance of P. panamensis in the Mexican Pacific revealed that northern populations from Baja California represent its center of abundance; and southern depauperate populations along the continental margin are peripheral relative to it. Genetic patterns of diversity and structure of nuclear DNA sequences (ribosomal DNA and a single copy open reading frame) and five alloenzymatic loci partially agreed with rel-ACH predictions. We found higher diversity levels in peninsular populations and significant differentiation between peninsular and continental colonies. In addition, continental populations showed higher levels of differentiation and lower connectivity than peninsular populations in the absence of isolation by distance in each region. Some discrepancies with model expectations may relate to the influence of significant habitat discontinuities in the face of limited dispersal potential. Environmental data analyses and niche modeling allowed us to identify temperature, water clarity, and substrate availability as the main factors correlating with patterns of abundance, genetic diversity, and structure, which may hold the key to the survival of P. panamensis in the face of widespread environmental degradation. PMID:24324860

Bioactivity of enoxaparin in critically ill patients with normal renal function

PubMed Central

Gouya, Ghazaleh; Palkovits, Stefan; Kapiotis, Stylianos; Madl, Christian; Locker, Gottfried; Stella, Alexander; Wolzt, Michael; Heinz, Gottfried

2012-01-01

Aim In critically ill patients, reduced anti-FXa plasma activity following subcutaneous administration of enoxaparin or nadroparin has been described. In this study, we aimed to investigate the bioactivity of enoxaparin in critically ill patients and controls. Methods A prospective, controlled, open label study was performed on a medical intensive care unit (ICU) and a general medical ward. Fifteen ICU patients (male = 12, median age 52 years [IQR 40−65], with a median Simplified Acute Physiology Score of 30 [IQR 18−52]) and sex- and age-matched medical ward patients were included. The anti-FXa plasma activity was measured after a single subcutaneous dose of 40 mg enoxaparin. The thrombus size of a clot formed in an ex vivo perfusion chamber and endogenous thrombin potential (ETP) were measured. Results The anti-FXa plasma activity increased significantly after enoxaparin administration, with peak levels at 3 h after treatment, but was comparable between the ICU and medical ward groups (median 0.16 IU ml−1[IQR 0−0.22 IU ml−1]vs. 0.2 IU ml−1[IQR 0.15−0.27 IU ml−1], respectively, P= 0.13). The area under the anti-FXa activity curve from 0–12 h was similar between the groups (median 0.97 IU ml−1 h [IQR 0.59−2.1] and 1.48 IU ml−1 h1[IQR 0.83−1.62], P= 0.42 for the ICU group compared with the control group, respectively). The ETP was lower in the ICU group (P < 0.05) at baseline, but it was comparable at 3 h between the groups. Thrombus size decreased at 3 h compared with predose (P= 0.029) and was not different between the groups. Conclusion Similar bioactivity was achieved with a standard dose of subcutaneous enoxaparin in this selected cohort of ICU and general ward patients with normal renal function. PMID:23227470

The effect of alcohol outlets, sales and trading hours on alcohol-related injuries presenting at emergency departments in Perth, Australia, from 2002 to 2010.

PubMed

Hobday, Michelle; Chikritzhs, Tanya; Liang, Wenbin; Meuleners, Lynn

2015-12-01

Few studies have investigated the combined effects of alcohol sales, outlet numbers and trading hours on alcohol-related harms. This study aimed to test whether associations: (i) exist between alcohol-related emergency department (ED) injuries and alcohol sales and counts of outlets; (ii) vary between on- and off-premises outlets; and (iii) vary by trading hours conditions [extended trading permits (ETP) versus standard hours]. Panel study using 117 postcodes over 8 years (2002-10): 936 data points. Perth, Australia. ED injury presentations, aggregated to postcode-level. Alcohol-related injuries were identified using time-based surrogate measures: night injuries (n=51,241) and weekend night injuries (n=30,682). Measures of alcohol availability included number of outlets with standard and extended trading hours and mean sales per postcode. Negative binomial regression modelling with random effects was used to examine associations between availability and alcohol-related injury, controlling for socio-demographic characteristics. (i) Night injuries were associated significantly with counts of on-premises outlets [incident rate ratio (IRR)=1.046; 95% confidence interval (CI)=1.014-1.078] and sales per off-premises outlet (IRR=1.019; 95% CI=1.004-1.035); (ii) counts of on-premises outlets were positively associated with alcohol-related injury while counts of off-premises outlets indicated a negative association; and (iii) weekend night injuries increased by about 5% per on-premises outlet with an ETP (IRR=1.049; 95% CI=1.015-1.084) and by less than 1% for outlets with standard trading hours (IRR=1.008; 95% CI=1.004-1.013). Regions of Perth, Australia with greater off-premises alcohol sales and counts of on-premises alcohol outlets, particularly those with extended trading hours, appear to have higher levels of alcohol-related injuries. © 2015 Society for the Study of Addiction.

DWPF DECON FRIT SUPERNATE ANALYSIS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peeler, D.; Crawford, C.

2010-09-22

The Savannah River National Laboratory (SRNL) has been requested to perform analyses on samples of the Defense Waste Processing Facility (DWPF) decon frit slurry (i.e., supernate samples and sump solid samples). Four 1-L liquid slurry samples were provided to SRNL by Savannah River Remediation (SRR) from the 'front-end' decon activities. Additionally, two 1-L sump solids samples were provided to SRNL for compositional and physical analysis. This report contains the results of the supernate analyses, while the solids (sump and slurry) results will be reported in a supplemental report. The analytical data from the decon frit supernate indicate that all ofmore » the radionuclide, organic, and inorganic concentrations met the limits in Revision 4 of the Effluent Treatment Plant (ETP) Waste Acceptance Criteria (WAC) with the exception of boron. The ETP WAC limit for boron is 15.0 mg/L while the average measured concentration (based on quadruplicate analysis) was 15.5 mg/L. The measured concentrations of Li, Na, and Si were also relatively high in the supernate analysis. These results are consistent with the relatively high measured value of B given the compositional make-up of Frit 418. Given these results, it was speculated that either (a) Frit 418 was dissolving into the supernate or aqueous fraction and/or (b) fine frit particulates were carried forward to the analytical instrument based on the sampling procedure used (i.e., the supernate samples were not filtered - only settled with the liquid fraction being transferred with a pipette). To address this issue, a filtered supernate sample (using a 0.45 um filter) was prepared and submitted for analysis. The results of the filtered sample were consistent with 'unfiltered or settled' sample - relatively high values of B, Li, Na, and Si were found. This suggests that Frit 418 is dissolving in the liquid phase which could be enhanced by the high surface area of the frit fines or particulates in suspension. Based on the results of this study, it is recommended that DWPF re-evaluate the technical basis for the B WAC limit (the only component that exceeds the ETP WAC limit from the supernate analyses) or assess if a waiver or exception can be obtained for exceeding this limit. Given the possible dissolution of B, Li, Na, and Si into the supernate (due to dissolution of frit), DWPF may need to assess if the release of these frit components into the supernate are a concern for the disposal options being considered. It should be noted that the results of this study may not be representative of future decon frit solutions or sump/slurry solids samples. Therefore, future DWPF decisions regarding the possible disposal pathways for either the aqueous or solid portions of the Decon Frit system need to factor in the potential differences. More specifically, introduction of a different frit or changes to other DWPF flowsheet unit operations (e.g., different sludge batch or coupling with other process streams) may impact not only the results but also the conclusions regarding acceptability with respect to the ETF WAC limits.« less

Does plant diversity affect the water balance of established grassland systems?

NASA Astrophysics Data System (ADS)

Leimer, Sophia; Bischoff, Sebastian; Blaser, Stefan; Boch, Steffen; Busch, Verena; Escher, Peter; Fischer, Markus; Kaupenjohann, Martin; Kerber, Katja; Klaus, Valentin; Michalzik, Beate; Prati, Daniel; Schäfer, Deborah; Schmitt, Barbara; Schöning, Ingo; Schwarz, Martin T.; Siemens, Jan; Thieme, Lisa; Wilcke, Wolfgang

2017-04-01

The water cycle drives nutrient cycles and plant productivity. The impact of land use on the water cycle has been extensively studied and there is experimental evidence that biodiversity modifies the water cycle in grasslands. However, the combined influences of land-use and associated biodiversity on the water cycle in established land-use systems are unclear. Therefore, we investigated how evapotranspiration (ETa), downward water flux (DF), and capillary rise (CR) in topsoil and subsoil are related to land-use and plant diversity in established, commercially managed grassland and compared these results to findings from experiments where plant diversity was manipulated. In three Central European regions ("Biodiversity Exploratories"), we studied 29 grassland plots (50 m x 50 m; 9-11 plots per region) from 2010 to 2015. The land-use types cover pasture, mown pasture, and meadow in at least triplicate per region. On each plot, we measured soil water contents, meteorological data (hourly resolution), cumulative precipitation (biweekly), plant species richness, the number of plants in the functional groups of grasses, herbs, and legumes (annually), and root biomass (once). Potential evapotranspiration (ETp) was calculated from meteorological data per plot. Missing data points of ETp and soil water contents were estimated with Bayesian hierarchical models. ETa, DF, and CR were calculated for two soil layers with a soil water balance model. The model is based on changes in soil water storage between subsequent observation dates and ETp, which was partitioned between soil layers according to root distribution. Water fluxes in annual resolution were statistically analyzed for land-use and biodiversity effects using repeated-measures analysis of variance (ANOVA). Land-use type did not affect water fluxes. Species richness did not influence DF and CR. DF from topsoil was higher on plots with more grass species, which is opposite to the results from a manipulative biodiversity experiment. The number of grasses and herbs influenced CR into topsoil. ETa from topsoil decreased with increasing species richness while ETa from subsoil increased. Opposing effects on ETa in the two soil layers were also observed for the numbers of herb and legume species. In manipulative biodiversity experiments, opposing effects on ETa from different soil layers are explained by higher plant cover and biomass in species-rich mixtures, reducing evaporation by shading of the topsoil, and deeper roots in species-rich mixtures, facilitating water use and increasing transpiration from subsoil. In our study, biomass decreased with increasing species richness because fertilizer application increased biomass production and decreased species richness. Plots with more grasses showed lower ETa from topsoil than plots with less grasses. However, the within-subject effects indicated higher ETa from topsoil in years with more grasses on individual plots than in years with less grasses. The latter finding complies with the results from a manipulative biodiversity experiment, which has homogeneous soil properties and management. The opposite between-subject effect is probably caused by variations in environmental conditions between plots. This indicates that processes controlling the biodiversity-water cycle relationship vary in real-world systems with environmental conditions, which are largely controlled for in manipulative biodiversity experiments.

DEVELOPMENT OF EMERGING TECHNOLOGIES WITHIN THE SITE PROGRAM

EPA Science Inventory

The Site Program is formed by five research programs: the Demonstration Program, the Emerging Technology Program, the Measurement and Monitoring Technology Development Program, the Innovative Technology Program, and the Technology Transfer Program. The Emerging Technology (ET) P...

Initiating the 2002 Mars Science Laboratory (MSL) Technology Program

NASA Technical Reports Server (NTRS)

Caffrey, Robert T.; Udomkesmalee, Gabriel; Hayati, Samad A.; Henderson, Rebecca

2004-01-01

The Mars Science Laboratory (MSL) Project is an aggressive mission launching in 2009 to investigate the Martian environment and requires new capabilities that are currently are not available. The MSL Technology Program is developing a wide-range of technologies needed for this Mission and potentially other space missions. The MSL Technology Program reports to both the MSL Project and the Mars Technology Program (MTP). The dual reporting process creates a challenging management situation, but ensures the new technology meets both the specific MSL requirements and the broader Mars Program requirements. MTP is a NASA-wide technology development program managed by JPL and is divided into a Focused Program and a Base Program. The MSL Technology Program is under the focused program and is tightly coupled to MSL's mission milestones and deliverables. The technology budget is separate from the flight Project budget, but the technology's requirements and the development process are tightly coordinated with the Project. The MSL Technology Program combines the proven management techniques of flight projects with the commercial technology management strategies of industry and academia, to create a technology management program that meets the short-term requirements of MSL and the long-term requirements of MTP. This paper examines the initiation of 2002 MSL Technology program. Some of the areas discussed in this paper include technology definition, task selection, technology management, and technology assessment. This paper also provides an update of the 2003 MSL technology program and examines some of the drivers that changed the program from its initiation.

Overview of Mars Technology Program

NASA Technical Reports Server (NTRS)

Hayati, Samad A.

2006-01-01

This viewgraph presentation reviews the development of a technology program leading to Mars missions. The presentation includes: the goals of technology program, elements of technology program, program metrics, major accomplishments, examples and Information about the Mars Technology Program.

Pacific Coast Hindcast Deepwater Wave Information.

DTIC Science & Technology

1986-03-01

32 8 123^ 7.0-7.9 . . 3 ±7 9 191 8.-9 1 18a 02a9.0-99 5. 20 10.0+ 20 6 27 "TOTAL 8 17t 264 186 172 108 18 1 0 0 MEAN HS(M) 5.5 LARGEST HS(M): 12.3...2527 1184 181 58 10~o-i. 1 95o 141 ,. 3.0-3.9 434 219 432 1351 1878 765 10 51c. 4.0-4.9 53 162 56 340 8E6 626 44 L1175.0-5.9 30 46 46 366 264 63 e 56.0...DEVIATION OF HSIMETRES)= 1.9 STt WAPD DEVIATICO OF IP(SECONDS)= 2.4 -" L4.3SEST HSU1ETPES)= 14.8 IP (SECOODS)ASSCC. WITH THE LARGEST HSZ 14.3 AVE

The role of oxide structure on copper wire to the rubber adhesion

NASA Astrophysics Data System (ADS)

Su, Yea-Yang; Shemenski, Robert M.

2000-07-01

Most metals have an oxide layer on the surface. However, the structure of the oxide varies with the matrix composition, and depends upon the environmental conditions. A bronze coating, nominal composition of 98.5% Cu and balance of Sn, is applied to steel wire for reinforcing pneumatic tire beads and to provide adhesion to rubber. This work studied the influence of copper oxides on the bronze coating on adhesion during vulcanization. To emphasize the oxide structures, electrolytic tough pitch (ETP) copper wire was used instead of the traditional bronze-coated tire bead wire. Experimental results confirmed the hypothesis that cuprous oxide (Cu 2O) could significantly improve bonding between copper wire and rubber, and demonstrated that the interaction between rubber and oxide layer on wire is an electrochemical reaction.

Initiating the 2002 Mars Science Laboratory (MSL) Focused Technology Program

NASA Technical Reports Server (NTRS)

Caffrey, Robert T.; Udomkesmalee, Gabriel; Hayati, Samad A.

2004-01-01

The Mars Science Laboratory (MSL) Project is an aggressive mission launching in 2009 to deliver a new generation of rover safely to the surface of Mars and conduct comprehensive in situ investigations using a new generation of instruments. This system will be designed to land with precision and be capable of operating over a large percentage on the surface of Mars. It will have capabilities that will support NASA's scientific goals into the next decade of exphation. The MSL Technology program is developing a wide-range of technologies needed for this Mission and potentially other space missions. The MSL Technology Program reports to both the MSL Project and the Mars Technology Program (MTP). The dual reporting process creates a challenging management situation, but ensures the new technology meets both the specific MSL requirements and the broader Mars Program requirements. MTP is a NASA-wide technology development program managed by the Jet Propulsion Laboratory (JPL) and is divided into a Focused Program and a Base Program. The Focused Technology Program addresses technologies that are specific and critical to near-term missions, while the Base Technology Program addresses those technologies that are applicable to multiple missions and which can be characterized as longer term, higher risk, and high payoff technologies. The MSL Technology Program is under the Focused Program and is tightly coupled to MSL's mission milestones and deliverables. The technology budget is separate from the flight Project budget, but the technology s requirements and the development process are tightly coordinated with the Project. The Technology Program combines proven management techniques of flight projects with commercial and academic technology management strategies, to create a technology management program that meets the near-term requirements of MSL and the long-term requirements of MTP. This paper examines the initiation of 2002 MSL Technology program. Some of the areas discussed in this paper include technology definition, task selection, technology management, and technology assessment.

Generation of Platelet Microparticles after Cryopreservation of Apheresis Platelet Concentrates Contributes to Hemostatic Activity.

PubMed

Eker, İbrahim; Yılmaz, Soner; Çetinkaya, Rıza Aytaç; Pekel, Aysel; Ünlü, Aytekin; Gürsel, Orhan; Yılmaz, Sebahattin; Avcu, Ferit; Muşabak, Uğur; Pekoğlu, Ahmet; Ertaş, Zerrin; Açıkel, Cengizhan; Zeybek, Nazif; Kürekçi, Ahmet Emin; Avcı, İsmail Yaşar

2017-03-01

In the last decade, substantial evidence has accumulated about the use of cryopreserved platelet concentrates, especially in trauma. However, little reference has been made in these studies to the morphological and functional changes of platelets. Recently platelets have been shown to be activated by cryopreservation processes and to undergo procoagulant membrane changes resulting in the generation of platelet-derived microparticles (PMPs), platelet degranulation, and release of platelet-derived growth factors (PDGFs). We assessed the viabilities and the PMP and PDGF levels of cryopreserved platelets, and their relation with thrombin generation. Apheresis platelet concentrates (APCs) from 20 donors were stored for 1 day and cryopreserved with 6% dimethyl sulfoxide. Cryopreserved APCs were kept at -80 °C for 1 day. Thawed APCs (100 mL) were diluted with 20 mL of autologous plasma and specimens were analyzed for viabilities and PMPs by flow cytometry, for thrombin generation by calibrated automated thrombogram, and for PDGFs by enzyme-linked immunosorbent assay testing. The mean PMP and PDGF levels in freeze-thawed APCs were significantly higher (2763±399.4/µL vs. 319.9±80.5/µL, p<0.001 and 550.9±73.6 pg/mL vs. 96.5±49 pg/mL, p<0.001, respectively), but the viability rates were significantly lower (68.2±13.7% vs. 94±7.5%, p<.001) than those of fresh APCs. The mean endogenous thrombin potential (ETP) of freeze-thawed APCs was significantly higher than that of the fresh APCs (3406.1±430.4 nM.min vs. 2757.6±485.7 nM.min, p<0.001). Moreover, there was a significant positive poor correlation between ETP levels and PMP levels (r=0.192, p=0.014). Our results showed that, after cryopreservation, while levels of PMPs were increasing, significantly higher and earlier thrombin formation was occurring in the samples analyzed despite the significant decrease in viability. Considering the damage caused by the freezing process and the scarcity of evidence for their in vivo superiority, frozen platelets should be considered for use in austere environments, reserving fresh platelets for prophylactic use in blood banks.

Comparative effectiveness and safety of erythropoiesis-stimulating agents (biosimilars vs originators) in clinical practice: a population-based cohort study in Italy.

PubMed

Trotta, Francesco; Belleudi, Valeria; Fusco, Danilo; Amato, Laura; Mecozzi, Alessandra; Mayer, Flavia; Sansone, Massimo; Davoli, Marina; Addis, Antonio

2017-03-10

To evaluate the benefit/risk profile of epoetin α biosimilar with the erythropoiesis-stimulating agents (ESAs) originators when administered to naïve patients from clinical practice. Population-based observational cohort study. All residents in the Lazio Region, Italy, with chronic kidney disease (CKD) or cancer retrieved from the Electronic Therapeutic Plan (ETP) Register for ESA between 2012 and 2014. Overall, 13 470 incident ESA users were available for the analysis, 8161 in the CKD and 5309 in the oncology setting, respectively. ESAs identified through the ATC B03XA were divided into 3 groups: (1) biosimilars; (2) epoetin α originator and (3) other originators. Patients were exposed to ESAs from the date of activation of the ETP, until the end of a 6-month follow-up period. Effectiveness (all-cause mortality and blood transfusion) and safety (major cardiovascular events, blood dyscrasia). A composite outcome including all-cause mortality, blood transfusion and major cardiovascular events was predefined. HRs of any outcome were estimated through Cox regression. We found no differences between patients on biosimilars or all originators with regard to the risk estimates of all-cause mortality, blood transfusion, major cardiovascular events and blood dyscrasia in the CKD setting. The composite outcome confirmed these results (biosimilars vs epoetin α originators: adjusted HR=1.02, 95% CI 0.78 to 1.33; biosimilars vs other originators: adjusted HR=1.09, 95% CI 0.85 to 1.41). Comparable risk estimates were observed between biosimilars and all originators in the oncology setting. In both settings, our findings are suggestive of no difference between biosimilars and originators on relevant effectiveness and safety outcomes. This study may contribute to settling future drug policy for the health services and provides reassurance on the approval pathway for biosimilars. The oncology setting merits further research, taking into account tumour types, tumour stage and anticancer chemotherapy administered. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Elevated NT-proBNP is associated with unfavorably altered plasma fibrin clot properties in atrial fibrillation.

PubMed

Matusik, Paweł T; Matusik, Patrycja S; Kornacewicz-Jach, Zdzisława; Małecka, Barbara; Ząbek, Andrzej; Undas, Anetta

2017-09-15

Dense fibrin clot formation and hypofibrinolysis have been reported in atrial fibrillation (AF). It is unclear which factors affect fibrin clot properties in AF. We investigated plasma fibrin clot permeability (K s ), clot lysis time (CLT), endogenous thrombin potential (ETP) as well as other coagulation and fibrinolysis parameters along with N-terminal pro-B-type natriuretic peptide (NT-proBNP) in 160 AF patients (median age, 70.5years). Previous stroke (n=15; 9.4%) was associated with decreased K s (P=0.04) and longer CLT (P=0.005), together with higher antiplasmin (P=0.03) and lower tissue-type plasminogen activator (P=0.01). Lower K s (P=0.04) and tendency towards longer CLT (P=0.10) were observed in patients with a left atrium diameter>40mm. Patients with a CHA 2 DS 2 -VASc score of 3 or more (82.5%) were characterized by higher thrombin-activatable fibrinolysis inhibitor antigen (P=0.009). K s was inversely correlated with log NT-proBNP (r=-0.34, P<0.0001), plasminogen activator inhibitor-1 (PAI-1) antigen (r=-0.24, P=0.002) and C-reactive protein (r=-0.18, P=0.02), while CLT was positively correlated with log NT-proBNP (R=0.61, P<0.0001) and ETP (r=0.37, P<0.0001), which were interrelated (r=0.59, P<0.0001). After adjustment for potential confounders, PAI-1 (odds ratio [OR]: 1.14; 95% confidence interval [CI]: 1.02-1.26) was the only independent predictor of low K s (the lowest quartile,≤6×10 -9 cm 2 ), while NT-proBNP (OR: 1.21; 95% CI: 1.12-1.31) and PAI-1 (OR: 1.30; 95% CI: 1.12-1.51) both predicted prolonged CLT (the top quartile,≥109min). In AF patients prothrombotic fibrin clot properties assessed ex vivo are determined by PAI-1 and NT-proBNP and this phenotype is associated with prior ischemic stroke. Copyright © 2017 Elsevier B.V. All rights reserved.

The Mars Technology Program

NASA Technical Reports Server (NTRS)

Hayati, Samad A.

2002-01-01

Future Mars missions require new capabilities that currently are not available. The Mars Technology Program (MTP) is an integral part of the Mars Exploration Program (MEP). Its sole purpose is to assure that required technologies are developed in time to enable the baselined and future missions. The MTP is a NASA-wide technology development program managed by JPL. It is divided into a Focused Program and a Base Program. The Focused Program is tightly tied to the proposed Mars Program mission milestones. It involves time-critical deliverables that must be developed in time for infusion into the proposed Mars 2005, and, 2009 missions. In addition a technology demonstration mission by AFRL will test a LIDAR as part of a joint NASNAFRL experiment. This program bridges the gap between technology and projects by vertically integrating the technology work with pre-project development in a project-like environment with critical dates for technology infusion. A Base Technology Program attacks higher riskhigher payoff technologies not in the critical path of missions.

75 FR 3791 - Broadband Technology Opportunities Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-22

... Department of Agriculture Rural Utilities Service Broadband Technology Opportunities Program; Notices #0;#0... 0660-ZA28 Broadband Technology Opportunities Program AGENCY: National Telecommunications and... for the Broadband Technology Opportunities Program (BTOP or Program) that the agency established...

Site Remediation Technology InfoBase: A Guide to Federal Programs, Information Resources, and Publications on Contaminated Site Cleanup Technologies. First Edition

NASA Technical Reports Server (NTRS)

1998-01-01

Table of Contents: Federal Cleanup Programs; Federal Site Remediation Technology Development Assistance Programs; Federal Site Remediation Technology Development Electronic Data Bases; Federal Electronic Resources for Site Remediation Technology Information; Other Electronic Resources for Site Remediation Technology Information; Other Electronic Resources for Site Remediation Technology Information; Selected Bibliography: Federal Publication on Alternative and Innovative Site Remediation; and Appendix: Technology Program Contacts.

Mississippi Curriculum Framework for Drafting and Design Technology (Program CIP: 48.0102--Architectural Drafting Technology) (Program CIP: 48.0101--General Drafting). Postsecondary Programs.

ERIC Educational Resources Information Center

Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the two course sequences of the state's postsecondary-level drafting and design technology program: architectural drafting technology and drafting and design technology. Presented first are a program description and…

Space and nuclear research and technology

NASA Technical Reports Server (NTRS)

1975-01-01

A fact sheet is presented on the space and nuclear research and technology program consisting of a research and technology base, system studies, system technology programs, entry systems technology, and experimental programs.

Humanities Perspectives on Technology Program: Science, Technology & Society Program. Lehigh University, 1977-80.

ERIC Educational Resources Information Center

Cutcliffe, Stephen H., Ed.

Newsletter issues pertaining to Lehigh University's Humanities Perspectives on Technology (HPT) Program, which was renamed the Science, Technology and Society Program, are presented. Additionally, a newsletter article excerpt entitled "Elements of Technology in a Liberal Education" is included. Two 1977 issues of "HRP News,"…

Fuel Cell and Hydrogen Technologies Program | Hydrogen and Fuel Cells |

Science.gov Websites

NREL Fuel Cell and Hydrogen Technologies Program Fuel Cell and Hydrogen Technologies Program Through its Fuel Cell and Hydrogen Technologies Program, NREL researches, develops, analyzes, and validates fuel cell and hydrogen production, delivery, and storage technologies for transportation

75 FR 27984 - Broadband Technology Opportunities Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-19

....: 0907141137-0222-10] RIN 0660-ZA28 Broadband Technology Opportunities Program AGENCY: National...; Reopening of Application Filing Window for Broadband Technology Opportunities Program Comprehensive... filing window for the Broadband Technology Opportunities Program (BTOP) that the agency established...

75 FR 20038 - Railroad Safety Technology Grant Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-16

...] Railroad Safety Technology Grant Program AGENCY: Federal Railroad Administration, Department of Transportation. ACTION: Notice of Funds Availability, Railroad Safety Technology Program-Correction of Grant... Railroad Safety Technology Program, in the section, ``Requirements and Conditions for Grant Applications...

NASA's Microgravity Technology Report, 1996: Summary of Activities

NASA Technical Reports Server (NTRS)

Kierk, Isabella

1996-01-01

This report covers technology development and technology transfer activities within the Microgravity Science Research Programs during FY 1996. It also describes the recent major tasks under the Advanced Technology Development (ATD) Program and identifies current technology requirements. This document is consistent with NASA,s Enteprise for the Human Exploration and development of Space (HEDS) Strategic Plan. This annual update reflects changes in the Microgravity Science Research Program's new technology activities and requirements. Appendix A. FY 1996 Advanced Technology Development. Program and Project Descriptions. Appendix B. Technology Development.

34 CFR 403.1 - What is the State Vocational and Applied Technology Education Program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false What is the State Vocational and Applied Technology... TECHNOLOGY EDUCATION PROGRAM General § 403.1 What is the State Vocational and Applied Technology Education Program? (a) Under the State Vocational and Applied Technology Education Program, the Secretary makes...

Mississippi Curriculum Framework for Computer Information Systems Technology. Computer Information Systems Technology (Program CIP: 52.1201--Management Information Systems & Business Data). Computer Programming (Program CIP: 52.1201). Network Support (Program CIP: 52.1290--Computer Network Support Technology). Postsecondary Programs.

ERIC Educational Resources Information Center

Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for two programs in the state's postsecondary-level computer information systems technology cluster: computer programming and network support. Presented in the introduction are program descriptions and suggested course…

CSTI Earth-to-orbit propulsion research and technology program overview

NASA Technical Reports Server (NTRS)

Gentz, Steven J.

1993-01-01

NASA supports a vigorous Earth-to-orbit (ETO) research and technology program as part of its Civil Space Technology Initiative. The purpose of this program is to provide an up-to-date technology base to support future space transportation needs for a new generation of lower cost, operationally efficient, long-lived and highly reliable ETO propulsion systems by enhancing the knowledge, understanding and design methodology applicable to advanced oxygen/hydrogen and oxygen/hydrocarbon ETO propulsion systems. Program areas of interest include analytical models, advanced component technology, instrumentation, and validation/verification testing. Organizationally, the program is divided between technology acquisition and technology verification as follows: (1) technology acquisition; and (2) technology verification.

76 FR 18166 - Technology Innovation Program Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-01

... DEPARTMENT OF COMMERCE National Institute of Standards and Technology Technology Innovation Program Advisory Board AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of public meeting. SUMMARY: The Technology Innovation Program Advisory Board, National...

75 FR 62369 - Technology Innovation Program Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-08

... DEPARTMENT OF COMMERCE National Institute of Standards and Technology Technology Innovation Program Advisory Board AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of public meeting. SUMMARY: The Technology Innovation Program Advisory Board, National...

75 FR 22553 - Technology Innovation Program Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-29

... DEPARTMENT OF COMMERCE National Institute of Standards and Technology Technology Innovation Program Advisory Board AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of public meeting. SUMMARY: The Technology Innovation Program Advisory Board, National...

Drill cuttings mount formation study

NASA Astrophysics Data System (ADS)

Teh, Su Yean; Koh, Hock Lye

2014-07-01

Oil, Gas and Energy sector has been identified as an essential driving force in the Malaysian Economic Transformation Programs (ETP). Recently confirmed discovery of many offshore oil and gas deposits in Malaysian waters has ignited new confidence in this sector. However, this has also spurred intense interest on safeguarding the health and environment of coastal waters in Malaysia from adverse impact resulting from offshore oil and gas production operation. Offshore discharge of spent drilling mud and rock cuttings is the least expensive and simplest option to dispose of large volumes of drilling wastes. But this onsite offshore disposal may have adverse environmental impacts on the water column and the seabed. It may also pose occupational health hazards to the workers living in the offshore platforms. It is therefore important to model the transport and deposition of drilling mud and rock cuttings in the sea to enable proper assessment of their adverse impacts on the environment and the workers. Further, accumulation of drill particles on the seabed may impede proper operation of pipelines on the seabed. In this paper, we present an in-house application model TUNA-PT developed to cater to local oil and gas industry needs to simulate the dispersion and mount formation of drill cuttings by offshore oil and gas exploration and production platforms. Using available data on Malaysian coastal waters, simulation analyses project a pile formation on the seabed with a maximum height of about 1 m and pile radius of around 30 to 50 m. Simulated pile heights are not sensitive to the heights of release of the cuttings as the sensitivity has been mitigated by the depth of water.

34 CFR 400.1 - What is the purpose of the Vocational and Applied Technology Education Programs?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Technology Education Programs? 400.1 Section 400.1 Education Regulations of the Offices of the Department of... APPLIED TECHNOLOGY EDUCATION PROGRAMS-GENERAL PROVISIONS § 400.1 What is the purpose of the Vocational and Applied Technology Education Programs? (a) The purpose of the Vocational and Applied Technology Education...

76 FR 70970 - Technology Innovation Program Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-16

... DEPARTMENT OF COMMERCE National Institute of Standards and Technology Technology Innovation Program Advisory Board AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of public meeting. SUMMARY: The Technology Innovation Program (TIP) Advisory Board will...

Teaching Machines, Programming, Computers, and Instructional Technology: The Roots of Performance Technology.

ERIC Educational Resources Information Center

Deutsch, William

1992-01-01

Reviews the history of the development of the field of performance technology. Highlights include early teaching machines, instructional technology, learning theory, programed instruction, the systems approach, needs assessment, branching versus linear program formats, programing languages, and computer-assisted instruction. (LRW)

SUPERFUND INNOVATIVE TECHNOLOGY EVALUATION PROGRAM - TECHNOLOGY PROFILES 4th Edition

EPA Science Inventory

The Superfund Innovative Technology Evaluation (SITE) Program evaluates new and promising treatment technologies for cleanup of hazardous waste sites. The program was created to encourage the development and routine use of innovative treatment technologies. As a result, the SI...

Evidence-Based Medicine and State Health Care Coverage: The Washington Health Technology Assessment Program.

PubMed

Rothman, David J; Blackwood, Kristy L; Adair, Whitney; Rothman, Sheila M

2018-04-01

To evaluate the Washington State Health Technology Assessment Program (WHTAP). Washington State Health Technology Assessment Program proceedings in Seattle, Washington. We assessed the program through observation of its proceedings over a 5-year period, 2009-2014. We conducted detailed analyses of the documents it produced and reviewed relevant literature. Washington State Health Technology Assessment Program is unique compared to other state and federal programs. It has successfully applied evidence-based medicine to health care decision making, limited by the strength of available data. It claims cost savings, but they are not substantiated. Washington State Health Technology Assessment Program is a useful model for other states considering implementation of technology assessment programs. We provide key lessons for improving WHTAP's process. © Health Research and Educational Trust.

Center for development technology and program in technology and human affairs. [emphasizing technology-based networks

NASA Technical Reports Server (NTRS)

Wong, M. D.

1974-01-01

The role of technology in nontraditional higher education with particular emphasis on technology-based networks is analyzed nontraditional programs, institutions, and consortia are briefly reviewed. Nontraditional programs which utilize technology are studied. Technology-based networks are surveyed and analyzed with regard to kinds of students, learning locations, technology utilization, interinstitutional relationships, cost aspects, problems, and future outlook.

34 CFR 400.9 - What additional requirements govern the Vocational and Applied Technology Education Programs?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Applied Technology Education Programs? 400.9 Section 400.9 Education Regulations of the Offices of the... VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAMS-GENERAL PROVISIONS § 400.9 What additional requirements govern the Vocational and Applied Technology Education Programs? In addition to the Act, applicable...

Strengthening 4-H Program Communication through Technology

ERIC Educational Resources Information Center

Robideau, Kari; Santl, Karyn

2011-01-01

Advances in technology are transforming how youth and parents interact with programs. The Strengthening 4-H Communication through Technology project was implemented in eight county 4-H programs in Northwest Minnesota. This article outlines the intentional process used to effectively implement technology in program planning. The project includes:…

34 CFR 400.9 - What additional requirements govern the Vocational and Applied Technology Education Programs?

Code of Federal Regulations, 2012 CFR

2012-07-01

... Applied Technology Education Programs? 400.9 Section 400.9 Education Regulations of the Offices of the... VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAMS-GENERAL PROVISIONS § 400.9 What additional requirements govern the Vocational and Applied Technology Education Programs? In addition to the Act, applicable...

34 CFR 400.9 - What additional requirements govern the Vocational and Applied Technology Education Programs?

Code of Federal Regulations, 2014 CFR

2014-07-01

... Applied Technology Education Programs? 400.9 Section 400.9 Education Regulations of the Offices of the... VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAMS-GENERAL PROVISIONS § 400.9 What additional requirements govern the Vocational and Applied Technology Education Programs? In addition to the Act, applicable...

34 CFR 400.9 - What additional requirements govern the Vocational and Applied Technology Education Programs?

Code of Federal Regulations, 2011 CFR

2011-07-01

... Applied Technology Education Programs? 400.9 Section 400.9 Education Regulations of the Offices of the... VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAMS-GENERAL PROVISIONS § 400.9 What additional requirements govern the Vocational and Applied Technology Education Programs? In addition to the Act, applicable...

34 CFR 400.9 - What additional requirements govern the Vocational and Applied Technology Education Programs?

Code of Federal Regulations, 2013 CFR

2013-07-01

... Applied Technology Education Programs? 400.9 Section 400.9 Education Regulations of the Offices of the... VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAMS-GENERAL PROVISIONS § 400.9 What additional requirements govern the Vocational and Applied Technology Education Programs? In addition to the Act, applicable...

Clean Coal Technology Demonstration Program: Program Update 1998

DOE Office of Scientific and Technical Information (OSTI.GOV)

Assistant Secretary for Fossil Energy

1999-03-01

Annual report on the Clean Coal Technology Demonstration Program (CCT Program). The report address the role of the CCT Program, implementation, funding and costs, accomplishments, project descriptions, legislative history, program history, environmental aspects, and project contacts. The project descriptions describe the technology and provides a brief summary of the demonstration results.

10 CFR 611.202 - Advanced Technology Vehicle Manufacturing Facility Award Program.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Advanced Technology Vehicle Manufacturing Facility Award... TECHNOLOGY VEHICLES MANUFACTURER ASSISTANCE PROGRAM Facility/Funding Awards § 611.202 Advanced Technology Vehicle Manufacturing Facility Award Program. DOE may issue, under the Advanced Technology Vehicle...

10 CFR 611.202 - Advanced Technology Vehicle Manufacturing Facility Award Program.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Advanced Technology Vehicle Manufacturing Facility Award... TECHNOLOGY VEHICLES MANUFACTURER ASSISTANCE PROGRAM Facility/Funding Awards § 611.202 Advanced Technology Vehicle Manufacturing Facility Award Program. DOE may issue, under the Advanced Technology Vehicle...

10 CFR 611.202 - Advanced Technology Vehicle Manufacturing Facility Award Program.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Advanced Technology Vehicle Manufacturing Facility Award... TECHNOLOGY VEHICLES MANUFACTURER ASSISTANCE PROGRAM Facility/Funding Awards § 611.202 Advanced Technology Vehicle Manufacturing Facility Award Program. DOE may issue, under the Advanced Technology Vehicle...

10 CFR 611.202 - Advanced Technology Vehicle Manufacturing Facility Award Program.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Advanced Technology Vehicle Manufacturing Facility Award... TECHNOLOGY VEHICLES MANUFACTURER ASSISTANCE PROGRAM Facility/Funding Awards § 611.202 Advanced Technology Vehicle Manufacturing Facility Award Program. DOE may issue, under the Advanced Technology Vehicle...

10 CFR 611.202 - Advanced Technology Vehicle Manufacturing Facility Award Program.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Advanced Technology Vehicle Manufacturing Facility Award... TECHNOLOGY VEHICLES MANUFACTURER ASSISTANCE PROGRAM Facility/Funding Awards § 611.202 Advanced Technology Vehicle Manufacturing Facility Award Program. DOE may issue, under the Advanced Technology Vehicle...

NASA Funding Opportunities for Optical Fabrication and Testing Technology Development

NASA Technical Reports Server (NTRS)

Stahl, H. Philip

2013-01-01

Technologies to fabricate and test optical components are required for NASA to accomplish its highest priority science missions. For example, the NRC ASTRO2010 Decadal Survey states that an advanced large-aperture UVOIR telescope is required to enable the next generation of compelling astrophysics and exo-planet science; and that present technology is not mature enough to affordably build and launch any potential UVOIR mission concept. The NRC 2012 NASA Space Technology Roadmaps and Priorities report states that the highest priority technology in which NASA should invest to 'Expand our understanding of Earth and the universe' is a new generation of astronomical telescopes. And, each of the Astrophysics division Program Office Annual Technology Reports (PATR), identifies specific technology needs. NASA has a variety of programs to fund enabling technology development: SBIR (Small Business Innovative Research); the ROSES APRA and SAT programs (Research Opportunities in Space and Earth Science; Astrophysics Research and Analysis program; Strategic Astrophysics Technology program); and several Office of the Chief Technologist (OCT) technology development programs.

Research and Technology: 2003 Annual Report of the John F Kennedy Space Center

NASA Technical Reports Server (NTRS)

2003-01-01

The John F. Kennedy Space Center (KSC) is America's Spaceport Technology Center. The KSC technology development program encompasses the efforts of the entire KSC team, consisting of Government and contractor personnel, working in partnership with academic institutions and commercial industry. KSC's assigned mission areas are space launch operations and spaceport and range technologies. KSC's technology development customers include current space transportation programs, future space transportation programs / initiatives, and enabling technical programs. The KSC Research and Technology 2003 Annual Report encompasses the efforts of contributors to the KSC advanced technology development program and KSC technology transfer activities. Dr. Dave Bartine, KSC Chief Technologist, (321) 867-7069, is responsible for publication of this report and should be contacted for any desired information regarding KSC's research and technology development activities.

Aeronautics Research and Technology Program and specific objectives, fiscal year 1982

NASA Technical Reports Server (NTRS)

Olstad, W. B.

1981-01-01

The Aeronautics Research and Technology program is broken down into two program areas (research and technology base, and systems technology programs) which are further broken down into succeedingly more detailed activities to form a work breakdown structure for the aeronautics program: program area, program/discipline objective, specific objective, and research and technology objective and plan (RTOP). A detailed view of this work breakdown structure down to the specific objective level is provided, and goals or objectives at each of these levels are set forth. What is to be accomplished and why are addressed, but not how. The letter falls within the domain of the RTOP.

Impact of emerging technologies on future combat aircraft agility

NASA Technical Reports Server (NTRS)

Nguyen, Luat T.; Gilert, William P.

1990-01-01

The foreseeable character of future within-visual-range air combat entails a degree of agility which calls for the integration of high-alpha aerodynamics, thrust vectoring, intimate pilot/vehicle interfaces, and advanced weapons/avionics suites, in prospective configurations. The primary technology-development programs currently contributing to these goals are presently discussed; they encompass the F-15 Short Takeoff and Landing/Maneuver Technology Demonstrator Program, the Enhanced Fighter Maneuverability Program, the High Angle-of-Attack Technology Program, and the X-29 Technology Demonstrator Program.

Assessing the Impact and Effectiveness of the Advanced Technological Education (ATE) Program. Survey Results 2004. Volume III: Status of ATE Projects and Articulation Partnerships

ERIC Educational Resources Information Center

Coryn, Chris L.; Gullickson, Arlen R.; Hanssen, Carl E.

2004-01-01

The Advanced Technological Education (ATE) program is a federally funded program designed to educate technicians for the high-technology disciplines that drive the United State's economy. As stated in the ATE program guidelines, this program promotes improvement in technological education at the undergraduate and secondary school levels by…

Analysis of Engineering Content within Technology Education Programs

ERIC Educational Resources Information Center

Fantz, Todd D.; Katsioloudis, Petros J.

2011-01-01

In order to effectively teach engineering, technology teachers need to be taught engineering content, concepts, and related pedagogy. Some researchers posit that technology education programs may not have enough content to prepare technology teachers to teach engineering design. Certain technology teacher education programs have responded by…

Women in Technology: The Evolution of a Simple Program That Works.

ERIC Educational Resources Information Center

Crumb, Jean Marie; Fenton, Ray

Three papers present views on women in technology programs and occupations, and on Corning Community College's (CCC's) program to encourage women to enter technological fields in which they have been historically underrepresented. First, Edward F. Herman presents the historical background to the development of CCC's Women in Technology program,…

15 CFR 296.33 - Annual report.

Code of Federal Regulations, 2010 CFR

2010-01-01

... STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS TECHNOLOGY INNOVATION PROGRAM... House of Representatives a report describing the Technology Innovation Program's activities, including a... for management of programs to stimulate high-risk, high-reward research. ...

NASA Technology Applications Team

NASA Technical Reports Server (NTRS)

1979-01-01

The contributions of NASA to the advancement of the level of the technology base of the United States are highlighted. Technological transfer from preflight programs, the Viking program, the Apollo program, and the Shuttle and Skylab programs is reported.

34 CFR 400.2 - What programs are governed by these regulations?

Code of Federal Regulations, 2010 CFR

2010-07-01

... VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAMS... apply to the Vocational and Applied Technology Education Programs as follows: (a) State-administered programs. (1) State Vocational and Applied Technology Education Program (34 CFR part 403). (2) State...

Audiovisual Programming. Technology Learning Activity. Teacher Edition. Technology Education Series.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This packet of technology learning activity (TLA) materials on audiovisual programming for students in grades 6-10 consists of a technology education overview, information on use, and the instructor's and student's sections. The overview discusses the technology education program and materials. Components of the instructor's and student's sections…

Identifying new technologies that save energy and reduce costs to the Federal sector: The New Technology Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hunt, W.D.M.; Conover, D.R.; Stockmeyer, M.K.

1995-11-01

In 1990 the New Technology Demonstration Program (formerly the Test Bed Demonstration Program) was initiated by the US Department of Energy`s Office (DOE`s) of Federal Energy Management Programs with the purpose of accelerating the introduction of new technologies into the Federal sector. The program has since expanded into a multi-laboratory collaborative effort that evaluates new technologies and shares the results with the Federal design and procurement communities. These evaluations are performed on a collaborative basis which typically includes technology manufacturers, Federal facilities, utilities, trade associations, research institutes, and other in partnership with DOE. The end result is a range ofmore » effective technology transfer tools that provide operations and performance data on new technologies to Federal designers, building managers, and procurement officials. These tools assist in accelerating a technology`s Federal application and realizing reductions in energy consumption and costs.« less

Free piston space Stirling technology program

NASA Technical Reports Server (NTRS)

Dochat, G. R.; Dhar, M.

1989-01-01

MTI recently completed an initial technology feasibility program for NASA by designing, fabricating and testing a space power demonstrator engine (SPDE). This program, which confirms the potential of free-piston Stirling engines, provided the major impetus to initiate a free-piston Stirling space engine (SSE) technology program. The accomplishments of the SPDE program are reviewed, and an overview of the SSE technology program and technical status to date is provided. It is shown that progress in both programs continues to justify its potential for either nuclear or solar space power missions.

NASA funding opportunities for optical fabrication and testing technology development

NASA Astrophysics Data System (ADS)

Stahl, H. Philip

2013-09-01

NASA requires technologies to fabricate and test optical components to accomplish its highest priority science missions. The NRC ASTRO2010 Decadal Survey states that an advanced large-aperture UVOIR telescope is required to enable the next generation of compelling astrophysics and exo-planet science; and, that present technology is not mature enough to affordably build and launch any potential UVOIR mission concept. The NRC 2012 NASA Space Technology Roadmaps and Priorities Report states that the highest priority technology in which NASA should invest to `Expand our understanding of Earth and the universe' is next generation X-ray and UVOIR telescopes. Each of the Astrophysics division Program Office Annual Technology Reports (PATR) identifies specific technology needs. NASA has a variety of programs to fund enabling technology development: SBIR (Small Business Innovative Research); the ROSES APRA and SAT programs (Research Opportunities in Space and Earth Science; Astrophysics Research and Analysis program; Strategic Astrophysics Technology program); and several Office of the Chief Technologist (OCT) programs.

Review of V/STOL lift/cruise fan technology

NASA Technical Reports Server (NTRS)

Rolls, L. S.; Quigley, H. C.; Perkins, R. G., Jr.

1976-01-01

This paper presents an overview of supporting technology programs conducted to reduce the risk in the joint NASA/Navy Lift/Cruise Fan Research and Technology Aircraft Program. The aeronautical community has endeavored to combine the low-speed and lifting capabilities of the helicopter with the high-speed capabilities of the jet aircraft; recent developments have indicated a lift/cruise fan propulsion system may provide these desired characteristics. NASA and the Navy have formulated a program that will provide a research and technology aircraft to furnish viability of the lift/cruise fan aircraft through flight experiences and obtain data on designs for future naval and civil V/STOL aircraft. The supporting technology programs discussed include: (1) design studies for operational aircraft, a research and technology aircraft, and associated propulsion systems; (2) wind-tunnel tests of several configurations; (3) propulsion-system thrust vectoring tests; and (4) simulation. These supporting technology programs have indicated that a satisfactory research and technology aircraft program can be accomplished within the current level of technology.

NASA Funding Opportunities for Optical Fabrication and Testing Technology Development

NASA Technical Reports Server (NTRS)

Stahl, H. Philip

2013-01-01

NASA requires technologies to fabricate and test optical components to accomplish its highest priority science missions. The NRC ASTRO2010 Decadal Survey states that an advanced large-aperture UVOIR telescope is required to enable the next generation of compelling astrophysics and exo-planet science; and, that present technology is not mature enough to affordably build and launch any potential UVOIR mission concept. The NRC 2012 NASA Space Technology Roadmaps and Priorities Report states that the highest priority technology in which NASA should invest to 'Expand our understanding of Earth and the universe' is next generation X-ray and UVOIR telescopes. Each of the Astrophysics division Program Office Annual Technology Reports (PATR) identifies specific technology needs. NASA has a variety of programs to fund enabling technology development: SBIR (Small Business Innovative Research); the ROSES APRA and SAT programs (Research Opportunities in Space and Earth Science; Astrophysics Research and Analysis program; Strategic Astrophysics Technology program); and several Office of the Chief Technologist (OCT) programs

SUPERFUND INNOVATIVE TECHNOLOGY EVALUATION PROGRAM TECHNOLOGY PROFILES: SIXTH EDITION

EPA Science Inventory

The Superfund Innovative Technology Evaluation (SITE) Program evaluates new and promising treatment and monitoring and measurement technologies for cleanup of hazardous waste sites. The program was created to encourage the development and routine use of innovative treatment techn...

SUPERFUND INNOVATIVE TECHNOLOGY EVALUATION PROGRAM - TECHNOLOGY PROFILES - SEVENTH EDITION

EPA Science Inventory

The Superfund Innovative Technology Evaluation (SITE) Program evaluates new and promising treatment and monitoring and measurement technologies for cleanup of hazardous waste sites. The program was created to encourage the development and routine use of innovative treatment techn...

75 FR 1591 - Green Technology Pilot Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-12

... DEPARTMENT OF COMMERCE Patent and Trademark Office Green Technology Pilot Program ACTION: Proposed... methods: E-mail: [email protected] . Include A0651-0062 Green Technology Pilot Program [email protected] in... green technologies, including greenhouse gas reduction. [[Page 1592

NASA's In Space Propulsion Technology Program Accomplishments and Lessons Learned

NASA Technical Reports Server (NTRS)

Johnson, Les C.; Harris, David

2008-01-01

NASA's In-Space Propulsion Technology (ISPT) Program was managed for 5 years at the NASA MSFC and significant strides were made in the advancement of key transportation technologies that will enable or enhance future robotic science and deep space exploration missions. At the program's inception, a set of technology investment priorities were established using an NASA-wide, mission-driven prioritization process and, for the most part, these priorities changed little - thus allowing a consistent framework in which to fund and manage technology development. Technologies in the portfolio included aerocapture, advanced chemical propulsion, solar electric propulsion, solar sail propulsion, electrodynamic and momentum transfer tethers, and various very advanced propulsion technologies with significantly lower technology readiness. The program invested in technologies that have the potential to revolutionize the robotic exploration of deep space. For robotic exploration and science missions, increased efficiencies of future propulsion systems are critical to reduce overall life-cycle costs and, in some cases, enable missions previously considered impossible. Continued reliance on conventional chemical propulsion alone will not enable the robust exploration of deep space - the maximum theoretical efficiencies have almost been reached and they are insufficient to meet needs for many ambitious science missions currently being considered. By developing the capability to support mid-term robotic mission needs, the program was to lay the technological foundation for travel to nearby interstellar space. The ambitious goals of the program at its inception included supporting the development of technologies that could support all of NASA's missions, both human and robotic. As time went on and budgets were never as high as planned, the scope of the program was reduced almost every year, forcing the elimination of not only the broader goals of the initial program, but also of funding for over half of the technologies in the original portfolio. In addition, the frequency at which the application requirements for the program changed exceeded the development time required to mature technologies: forcing sometimes radical rescoping of research efforts already halfway (or more) to completion. At the end of its fifth year, both the scope and funding of the program were at a minimum despite the program successfully meeting all of it's initial high priority objectives. This paper will describe the program, its requirements, technology portfolio, and technology maturation processes. Also discussed will be the major technology milestones achieved and the lessons learned from managing a $100M+ technology program.

NASA/Goddard Thermal Technology Overview 2014

NASA Technical Reports Server (NTRS)

Butler, Daniel; Swanson, Theodore D.

2014-01-01

This presentation summarizes the current plans and efforts at NASA Goddard to develop new thermal control technology for anticipated future missions. It will also address some of the programmatic developments currently underway at NASA, especially with respect to the Technology Development Program at NASA. While funding for basic technology development is still scarce, significant efforts are being made in direct support of flight programs. New technology development continues to be driven by the needs of future missions, and applications of these technologies to current Goddard programs will be addressed. Many of these technologies also have broad applicability to DOD, DOE, and commercial programs. Partnerships have been developed with the Air Force, Navy, and various universities to promote technology development. In addition, technology development activities supported by internal research and development (IRAD) program, the Small Business Innovative Research (SBIR) program, and the NASA Engineering and Safety Center (NESC), are reviewed in this presentation. Specific technologies addressed include; two-phase systems applications and issues on NASA missions, latest developments of electro-hydrodynamically pumped systems, development of high electrical conductivity coatings, and various other research activities. New Technology program underway at NASA, although funding is limited center dot NASA/GSFC's primary mission of science satellite development is healthy and vibrant, although new missions are scarce - now have people on overhead working new missions and proposals center dot Future mission applications promise to be thermally challenging center dot Direct technology funding is still very restricted - Projects are the best source for direct application of technology - SBIR thermal subtopic resurrected in FY 14 - Limited Technology development underway via IRAD, NESC, other sources - Administrator pushing to revive technology and educational programs at NASA - new HQ directorate established

ATP Interior Noise Technology and Flight Demonstration Program

NASA Technical Reports Server (NTRS)

Stephens, David G.; Powell, Clemans A.

1988-01-01

The paper provides an overview of the ATP (Advanced Turboprop Program) acoustics program with emphasis on the NASA technology program and the recent NASA/Industry demonstration programs aimed at understanding and controlling passenger cabin noise. Technology developments in propeller (source) noise, cabin noise transmission, and subjective acoustics are described. Finally, an overview of the industry demonstrator programs is presented.

Video and Computer Technologies for Extended-Campus Programming.

ERIC Educational Resources Information Center

Sagan, Edgar L.; And Others

This paper discusses video and computer technologies for extended-campus programming (courses and programs at off-campus sites). The first section provides an overview of the distance education program at the University of Kentucky (UK), and highlights the improved access to graduate and professional programs, advances in technology, funding,…

Spinoff, 1991

NASA Technical Reports Server (NTRS)

Haggerty, James J.

1991-01-01

This is an instrument of the Technology Utilization Program and is designed to heighten awareness of the technology available for transfer and its potential for public benefit. NASA's mainline programs, whose objectives require development of new technology and therefore expand the bank of technology available for transfer in future years, are summarized. Focus is on the representative sampling of spinoffs (spinoff, in this context, means products and processes developed as secondary applications of existing NASA technology) that resulted from NASA's mainline programs. The various mechanisms NASA employs to stimulate technology transfer are described and contact sources are listed in the appendix for further information about the Technology Utilization Program.

Environmental Technology Verification Program Fact Sheet

EPA Science Inventory

This is a Fact Sheet for the ETV Program. The EPA Environmental Technology Verification Program (ETV) develops test protocols and verifies the performance of innovative technologies that have the potential to improve protection of human health and the environment. The program ...

The SUPERFUND INNOVATIVE TECHNOLOGY EVALUATION program - Technology Profiles

EPA Science Inventory

The Superfund Innovative Technology Evaluation (SITE) program was created to evaluate new and promising treatment technologies for cleanup at hazardous waste sites. The mission of the SITE program is to encourage the development and routine use of innovative treatment technologie...

Control Robotics Programming Technology. Technology Learning Activity. Teacher Edition.

ERIC Educational Resources Information Center

Oklahoma State Dept. of Vocational and Technical Education, Stillwater. Curriculum and Instructional Materials Center.

This Technology Learning Activity (TLA) for control robotics programming technology in grades 6-10 is designed to teach students to construct and program computer-controlled devices using a LEGO DACTA set and computer interface and to help them understand how control technology and robotics affect them and their lifestyle. The suggested time for…

Research and technology annual report, FY 1990

NASA Technical Reports Server (NTRS)

1990-01-01

Given here is the annual report of the John C. Stennis Space Center (SSC), a NASA center responsible for testing NASA's large propulsion systems, developing supporting test technologies, conducting research in a variety of earth science disciplines, and facilitating the commercial uses of NASA-developed technologies. Described here are activities of the Earth Sciences Research Program, the Technology Development Program, commercial programs, the Technology Utilization Program, and the Information Systems Program. Work is described in such areas as forest ecosystems, land-sea interface, wetland biochemical flux, thermal imaging of crops, gas detectors, plume analysis, synthetic aperture radar, forest resource management, applications engineering, and the Earth Observations Commercial Applications Program.

2012 DOE Vehicle Technologies Program Annual Merit Review

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

The 2012 DOE Hydrogen Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting was held May 14-18, 2012 in Crystal City, Virginia. The review encompassed all of the work done by the Hydrogen Program and the Vehicle Technologies Program: a total of 309 individual activities were reviewed for Vehicle Technologies, by a total of 189 reviewers. A total of 1,473 individual review responses were received for the technical reviews.

Theme: Emerging Technologies.

ERIC Educational Resources Information Center

Malpiedi, Barbara J.; And Others

1989-01-01

Consists of six articles discussing the effect of emerging technologies on agriculture. Specific topics include (1) agriscience programs, (2) the National Conference on Agriscience and Emerging Occupations and Technologies, (3) biotechnology, (4) program improvement through technology, (5) the Agriscience Teacher of the Year program, and (6)…

75 FR 64692 - Green Technology Pilot Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-20

... DEPARTMENT OF COMMERCE Patent and Trademark Office Green Technology Pilot Program ACTION: Proposed...- 0062 Green Technology Pilot Program comment'' in the subject line of the message. Fax: 571-273-0112... permits patent applications pertaining to green technologies, including greenhouse gas reduction, to be...

Defense Science Board Task Force on The Manufacturing Technology Program: A Key to Affordably Equipping the Future Force

DTIC Science & Technology

2006-02-01

technology for cost and risk reduction of products, software, and processes; long-term, multi-Service needs; and disruptive technologies , both...initiatives and for disruptive technologies , the Office of the Secretary of Defense (OSD) can better promote the importance and value of the program...multi- Service programs, research in “ disruptive ” technologies , and SBIR programs. Balance current, near term, and future needs as well as small and

State investments in high-technology job growth.

PubMed

Leicht, Kevin T; Jenkins, J Craig

2017-07-01

Since the early 1970's state and local governments have launched an array of economic development programs designed to promote high-technology development. The question our analysis addresses is whether these programs promote long-term high-technology employment growth net of state location and agglomeration advantages. Proponents talk about an infrastructure strategy that promotes investment in public research and specialized infrastructure to attract and grow new high technology industries in specific locations, and a more decentralized entrepreneurial strategy that reinforces local agglomeration capacities by investing in new enterprises and products, promoting the development of local networks and partnerships. Our results support the entrepreneurial strategy, suggesting that state governments can accelerate high technology development by adopting market-supportive programs that complement private sector initiatives. In addition to positive direct benefits of technology deployment/transfer programs and SBIR programs, entrepreneurial programs affect change in high-technology employment in concert with existing locational and agglomeration advantages. Rural (i.e. low population density) states tend to benefit by technology development programs. Infrastructure strategy programs also facilitate high technology job growth in places where local advantages already exist. Our results suggest that critics of industrial policy are correct that high technology growth is organic and endogenous, yet state governments are able to "pick winners and losers" in ways that grow their local economy. Copyright © 2017 Elsevier Inc. All rights reserved.

Small engine technology programs

NASA Technical Reports Server (NTRS)

Niedzwiecki, Richard W.

1990-01-01

Described here is the small engine technology program being sponsored at the Lewis Research Center. Small gas turbine research is aimed at general aviation, commuter aircraft, rotorcraft, and cruise missile applications. The Rotary Engine program is aimed at supplying fuel flexible, fuel efficient technology to the general aviation industry, but also has applications to other missions. The Automotive Gas Turbine (AGT) and Heavy-Duty Diesel Transport Technology (HDTT) programs are sponsored by DOE. The Compound Cycle Engine program is sponsored by the Army. All of the programs are aimed towards highly efficient engine cycles, very efficient components, and the use of high temperature structural ceramics. This research tends to be generic in nature and has broad applications. The HDTT, rotary technology, and the compound cycle programs are all examining approaches to minimum heat rejection, or 'adiabatic' systems employing advanced materials. The AGT program is also directed towards ceramics application to gas turbine hot section components. Turbomachinery advances in the gas turbine programs will benefit advanced turbochargers and turbocompounders for the intermittent combustion systems, and the fundamental understandings and analytical codes developed in the research and technology programs will be directly applicable to the system projects.

Evaluation of the Advanced Subsonic Technology Program Noise Reduction Benefits

NASA Technical Reports Server (NTRS)

Golub, Robert A.; Rawls, John W., Jr.; Russell, James W.

2005-01-01

This report presents a detailed evaluation of the aircraft noise reduction technology concepts developed during the course of the NASA/FAA Advanced Subsonic Technology (AST) Noise Reduction Program. In 1992, NASA and the FAA initiated a cosponsored, multi-year program with the U.S. aircraft industry focused on achieving significant advances in aircraft noise reduction. The program achieved success through a systematic development and validation of noise reduction technology. Using the NASA Aircraft Noise Prediction Program, the noise reduction benefit of the technologies that reached a NASA technology readiness level of 5 or 6 were applied to each of four classes of aircraft which included a large four engine aircraft, a large twin engine aircraft, a small twin engine aircraft and a business jet. Total aircraft noise reductions resulting from the implementation of the appropriate technologies for each class of aircraft are presented and compared to the AST program goals.

Study of Federal technology transfer activities in areas of interest to NASA Office of Space and Terrestrial Applications

NASA Technical Reports Server (NTRS)

Madigan, J. A.; Earhart, R. W.

1978-01-01

Forty-three ongoing technology transfer programs in Federal agencies other than NASA were selected from over 200 current Federal technology transfer activities. Selection was made and specific technology transfer mechanisms utilized. Detailed information was obtained on the selected programs by reviewing published literature, and conducting telephone interviews with each program manager. Specific information collected on each program includes technology areas; user groups, mechanisms employed, duration of program, and level of effort. Twenty-four distinct mechanisms are currently employed in Federal technology transfer activities totaling $260 million per year. Typical applications of each mechanism were reviewed, and caveats on evaluating program effectiveness were discussed. A review of recent federally funded research in technology transfer to state and local governments was made utilizing the Smithsonian Science Information Exchange, and abstracts of interest to NASA were selected for further reference.

Physics of the Cosmos Program Annual Technology Report

NASA Technical Reports Server (NTRS)

Pham, Bruce Thai; Cardiff, Ann H.

2015-01-01

What's in this Report? What's New? This fifth Program Annual Technology Report (PATR) summarizes the Programs technology development activities for fiscal year (FY) 2015. The PATR serves four purposes.1. Summarize the technology gaps identified by the astrophysics community;2. Present the results of this years technology gap prioritization by the PCOS Technology Management Board (TMB);3. Report on newly funded PCOS Strategic Astrophysics Technology (SAT) projects; and4. Detail progress, current status, and activities planned for the coming year for all technologies supported by PCOS Supporting Research and Technology (SRT) funding in FY 2015. .

Effects of a Technology-Friendly Education Program on Pre-Service Teachers' Perceptions and Learning Styles

ERIC Educational Resources Information Center

Kim, Dong-Joong; Choi, Sang-Ho

2016-01-01

A technology-friendly teacher education program can make pre-service teachers more comfortable with using technology from laggard to innovator and change their learning styles in which they prefer the use of technology in teaching. It is investigated how a technology-friendly mathematics education program, which provided 49 pre-service teachers an…

SUPERFUND INNOVATIVE TECHNOLOGY EVALUATION PROGRAM: PROGRESS AND ACCOMPLISHMENTS - FISCAL YEAR 1991

EPA Science Inventory

The Superfund Innovative Technology Evaluation (SITE) program was the first major program for demonstrating and evaluating full-scale innovative treatment technologies at hazardous waste sites. Having concluded its fifth year, the SITE program is recognized as a leading advocate ...

Dental Laboratory Technology Program Guide.

ERIC Educational Resources Information Center

Georgia Univ., Athens. Dept. of Vocational Education.

This program guide contains the standard dental laboratory technology curriculum for both diploma programs and associate degree programs in technical institutes in Georgia. The curriculum encompasses the minimum competencies required for entry-level workers in the dental laboratory technology field. The general information section contains the…

2013 Building Technologies Office Program Peer Review Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

2013-11-01

The 2013 Building Technologies Office Program Peer Review Report summarizes the results of the 2013 Building Technologies Office (BTO) peer review, which was held in Washington, D.C., on April 2–4, 2013. The review was attended by over 300 participants and included presentations on 59 BTO-funded projects: 29 from BTO’s Emerging Technologies Program, 20 from the Commercial Buildings Integration Program, 6 from the Residential Buildings Integration Program, and 4 from the Building Energy Codes Program. This report summarizes the scores and comments provided by the independent reviewers for each project.

Technology advancements for the U.S. manned Space Station - An overview

NASA Technical Reports Server (NTRS)

Simon, William E.

1987-01-01

The structure and methodology of the Johnson Space Center (JSC) advanced development program is described. An overview of the program is given, and the technology transfer process to other disciplines is described. The test bed and flight experiment programs are described, as is the technology assessment which was performed at the end of the Phase B program. The technology program within each discipline is summarized, and the coordination and integration of the JSC program with the activities of other NASA centers and with work package contractors are discussed.

Controls-Structures Interaction (CSI) technology program summary. Earth orbiting platforms program area of the space platforms technology program

NASA Technical Reports Server (NTRS)

Newsom, Jerry R.

1991-01-01

Control-Structures Interaction (CSI) technology embraces the understanding of the interaction between the spacecraft structure and the control system, and the creation and validation of concepts, techniques, and tools, for enabling the interdisciplinary design of an integrated structure and control system, rather than the integration of a structural design and a control system design. The goal of this program is to develop validated CSI technology for integrated design/analysis and qualification of large flexible space systems and precision space structures. A description of the CSI technology program is presented.

The NASA technology push towards future space mission systems

NASA Technical Reports Server (NTRS)

Sadin, Stanley R.; Povinelli, Frederick P.; Rosen, Robert

1988-01-01

As a result of the new Space Policy, the NASA technology program has been called upon to a provide a solid base of national capabilities and talent to serve NASA's civil space program, commercial, and other space sector interests. This paper describes the new technology program structure and its characteristics, traces its origin and evolution, and projects the likely near- and far-term strategic steps. It addresses the alternative 'push-pull' approaches to technology development, the readiness levels to which the technology needs to be developed for effective technology transfer, and the focused technology programs currently being implemented to satisfy the needs of future space systems.

User needs as a basis for advanced technology. [U.S. civil space program

NASA Technical Reports Server (NTRS)

Mankins, John C.; Reck, Gregory M.

1992-01-01

The NASA Integrated Technology Plan (ITP) is described with treatment given to the identification of U.S. technology needs, space research and technology programs, and some ITP implementations. The ITP is based on the development and transfer of technologies relevant to the space program that also have significant implications for general technological research. Among the areas of technological research identified are: astrophysics, earth sciences, microgravity, and space physics. The Office of Space Science and Applications prioritizes the technology needs in three classes; the highest priority is given to submm and microwave technologies for earth sciences and astrophysics study. Other government and commercial needs are outlined that include cryogenic technologies, low-cost engines, advanced data/signal processing, and low-cost ELVs. It is demonstrated that by identifying and addressing these areas of user technology needs NASA's research and technology program can enhance U.S. trade and industrial competitiveness.

Component technology for stirling power converters

NASA Technical Reports Server (NTRS)

Thieme, Lanny G.

1991-01-01

NASA Lewis Research Center has organized a component technology program as part of the efforts to develop Stirling converter technology for space power applications. The Stirling Space Power Program is part of the NASA High Capacity Power Project of the Civil Space Technology Initiative (CSTI). NASA Lewis is also providing technical management for the DOE/Sandia program to develop Stirling converters for solar terrestrial power producing electricity for the utility grid. The primary contractors for the space power and solar terrestrial programs develop component technologies directly related to their goals. This Lewis component technology effort, while coordinated with the main programs, aims at longer term issues, advanced technologies, and independent assessments. An overview of work on linear alternators, engine/alternator/load interactions and controls, heat exchangers, materials, life and reliability, and bearings is presented.

NASA Goddard Thermal Technology Overview 2018

NASA Technical Reports Server (NTRS)

Butler, Dan; Swanson, Ted

2018-01-01

This presentation summarizes the current plans and efforts at NASA/Goddard to develop new thermal control technology for anticipated future missions. It will also address some of the programmatic developments currently underway at NASA, especially with respect to the NASA Technology Development Program. The effects of the recently submitted NASA budget will also be addressed. While funding for basic technology development is still tight, significant efforts are being made in direct support of flight programs. Thermal technology Implementation on current flight programs will be reviewed, and the recent push for Cube-sat mission development will also be addressed. Many of these technologies also have broad applicability to DOD, DOE, and commercial programs. Partnerships have been developed with the Air Force, Navy, and various universities to promote technology development. In addition, technology development activities supported by internal research and development (IRAD) program and the Small Business Innovative Research (SBIR) program are reviewed in this presentation. Specific technologies addressed include; two-phase systems applications and issues on NASA missions, latest developments of thermal control coatings, Atomic Layer Deposition (ALD), Micro-scale Heat Transfer, and various other research activities.

Research and technology operating plan summary: Fiscal year 1975 research and technology program. [space programs, energy technology, and aerospace sciences

NASA Technical Reports Server (NTRS)

1975-01-01

Summaries are presented of Research and Technology Operating Plans currently in progress throughout NASA. Citations and abstracts of the operating plans are presented along with a subject index, technical monitor index, and responsible NASA organization index. Research programs presented include those carried out in the Office of Aeronautics and Space Technology, Office of Energy Programs, Office of Applications, Office of Space Sciences, Office of Tracking and Data Acquisition, and the Office of Manned Space Flight.

ESTIMATING INNOVATIVE TECHNOLOGY COSTS FOR THE SITE PROGRAM

EPA Science Inventory

Among the objectives of the EPA`s Superfund Innovative Technology Evaluation (SITE) Program are two which pertain to the issue of economics: 1) That the program will provide a projected cost for each treatment technology demonstrated. 2) That the program will attempt to identify ...

30 CFR 402.7 - Water-Resources Technology Development Program.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 2 2011-07-01 2011-07-01 false Water-Resources Technology Development Program. 402.7 Section 402.7 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM AND THE WATER-RESOURCES TECHNOLOGY DEVELOPMENT PROGRAM Description of Water-Resources...

30 CFR 402.7 - Water-Resources Technology Development Program.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 2 2014-07-01 2014-07-01 false Water-Resources Technology Development Program. 402.7 Section 402.7 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM AND THE WATER-RESOURCES TECHNOLOGY DEVELOPMENT PROGRAM Description of Water-Resources...

30 CFR 402.7 - Water-Resources Technology Development Program.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Water-Resources Technology Development Program. 402.7 Section 402.7 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM AND THE WATER-RESOURCES TECHNOLOGY DEVELOPMENT PROGRAM Description of Water-Resources...

30 CFR 402.7 - Water-Resources Technology Development Program.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 2 2013-07-01 2013-07-01 false Water-Resources Technology Development Program. 402.7 Section 402.7 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM AND THE WATER-RESOURCES TECHNOLOGY DEVELOPMENT PROGRAM Description of Water-Resources...

30 CFR 402.7 - Water-Resources Technology Development Program.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 2 2012-07-01 2012-07-01 false Water-Resources Technology Development Program. 402.7 Section 402.7 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM AND THE WATER-RESOURCES TECHNOLOGY DEVELOPMENT PROGRAM Description of Water-Resources...

Transferring new technologies within the federal sector: The New Technology Demonstration Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Conover, D.R.; Hunt, D.M.

1994-08-01

The federal sector is the largest consumer of products in the United States and annually purchases almost 1.5 quads of energy measured at the building site at a cost of almost $10 billion (U.S. Department of Energy 1991). A review of design, construction, and procurement practices in the federal sector, as well as discussions with manufacturers and vendors, indicated that new technologies are not utilized in as timely a manner as possible. As a consequence of this technology transfer lag, the federal sector loses valuable energy and environmental benefits that can be derived through the application of new technologies. Inmore » addition, opportunities are lost to reduce federal energy expenditures and spur U.S. economic growth through the procurement of such technologies. In 1990, under the direction of the U.S. Department of Energy (DOE) Federal Energy Management Program, the Pacific Northwest Laboratory began the design of a program to accelerate the introduction of new U.S. technologies into the federal sector. Designated first as the Test Bed Demonstration Program and more recently the New Technology Demonstration Program, it sought to shorten the acceptance period of new technologies within the federal sector. By installing and evaluating various new technologies at federal facilities, the Program attempts to increase the acceptance of those new technologies through the results of {open_quotes}real-world{close_quotes} federal installations. Since that time, the Program has conducted new technology demonstrations and evaluations, evolved to address the need for more timely information transfer, and explored collaborative opportunities with other DOE offices and laboratories. This paper explains the processes by which a new technology demonstration project is implemented and presents a general description of the Program results to date.« less

COST EVALUATION STRATEGIES FOR TECHNOLOGIES TESTED UNDER THE ENVIRONMENTAL TECHNOLOGY VERIFICATION PROGRAM

EPA Science Inventory

This document provides a general set of guidelines that may be consistently applied for collecting, evaluation, and reporting the costs of technologies tested under the ETV Program. Because of the diverse nature of the technologies and industries covered in this program, each ETV...

77 FR 46909 - Small Business Innovation Research (SBIR) Program and Small Business Technology Transfer (STTR...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-06

... Technology Transfer (STTR) Program Policy Directives AGENCY: U.S. Small Business Administration. ACTION...) and Small Business Technology Transfer Program (STTR) Policy Directives. These amendments implement... to Edsel Brown, Assistant Director, Office of Technology, U.S. Small Business Administrator, 409...

Bridging the Technology Readiness "Valley of Death" Utilizing Nanosats

NASA Technical Reports Server (NTRS)

Bauer, Robert A.; Millar, Pamela S.; Norton, Charles D.

2015-01-01

Incorporating new technology is a hallmark of space missions. Missions demand ever-improving tools and techniques to allow them to meet the mission science requirements. In Earth Science, these technologies are normally expressed in new instrument capabilities that can enable new measurement concepts, extended capabilities of existing measurement techniques, or totally new detection capabilities, and also, information systems technologies that can enhance data analysis or enable new data analyses to advance modeling and prediction capabilities. Incorporating new technologies has never been easy. There is a large development step beyond demonstration in a laboratory or on an airborne platform to the eventual space environment that is sometimes referred to as the "technology valley of death." Studies have shown that non-validated technology is a primary cause of NASA and DoD mission delays and cost overruns. With the demise of the New Millennium Program within NASA, opportunities for demonstrating technologies in space have been rare. Many technologies are suitable for a flight project after only ground testing. However, some require validation in a relevant or a space flight environment, which cannot be fully tested on the ground or in airborne systems. NASA's Earth Science Technology Program has initiated a nimble program to provide a fairly rapid turn-around of space validated technologies, and thereby reducing future mission risk in incorporating new technologies. The program, called In-Space Validation of Earth Science Technology (InVEST), now has five tasks in development. Each are 3U CubeSats and they are targeted for launch opportunities in the 2016 time period. Prior to formalizing an InVEST program, the technology program office was asked to demonstrate how the program would work and what sort of technologies could benefit from space validation. Three projects were developed and launched, and have demonstrated the technologies that they set out to validate. This paper will provide a brief status of the pre-InVEST CubeSats, and discuss the development and status of the InVEST program. Figure

Two Inseparable Facets of Technology Integration Programs: Technology and Theoretical Framework

ERIC Educational Resources Information Center

Demir, Servet

2011-01-01

This paper considers the process of program development aiming at technology integration for teachers. For this consideration, the paper focused on an integration program which was recently developed as part of a larger project. The participants of this program were 45 in-service teachers. The program continued four weeks and the conduct of the…

Balanced program plan: analysis for biomedical and environmental research. Volume 5. Oil shale technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1976-06-01

Oil shale technology has been divided into two sub-technologies: surfaceprocessing and in-situ processing. Definition of the research programs is essentially an amplification of the five King-Muir categories: (A) pollutants: characterization, measurement, and monitoring; (B) physical and chemical processes and effects; (C) health effects; (D) ecological processes and effects; and (E) integrated assessment. Twenty-three biomedical and environmental research projects are described as to program title, scope, milestones, technology time frame, program unit priority, and estimated program unit cost.

Next Generation Launch Technology Program Lessons Learned

NASA Technical Reports Server (NTRS)

Cook, Stephen; Tyson, Richard

2005-01-01

In November 2002, NASA revised its Integrated Space Transportation Plan (ISTP) to evolve the Space Launch Initiative (SLI) to serve as a theme for two emerging programs. The first of these, the Orbital Space Plane (OSP), was intended to provide crew-escape and crew-transfer functions for the ISS. The second, the NGLT Program, developed technologies needed for safe, routine space access for scientific exploration, commerce, and national defense. The NGLT Program was comprised of 12 projects, ranging from fundamental high-temperature materials research to full-scale engine system developments (turbine and rocket) to scramjet flight test. The Program included technology advancement activities with a broad range of objectives, ultimate applications/timeframes, and technology maturity levels. An over-arching Systems Engineering and Analysis (SE&A) approach was employed to focus technology advancements according to a common set of requirements. Investments were categorized into three segments of technology maturation: propulsion technologies, launch systems technologies, and SE&A.

Surgical Technology Program Guide.

ERIC Educational Resources Information Center

Georgia Univ., Athens. Dept. of Vocational Education.

This surgical technology program guide presents the standard curriculum for technical institutes in Georgia. The curriculum addresses the minimum competencies for a surgical technology program. The program guide is designed to relate primarily to the development of those skills needed by individuals in the field to provide services in the…

Variable Cycle Engine Technology Program Planning and Definition Study

NASA Technical Reports Server (NTRS)

Westmoreland, J. S.; Stern, A. M.

1978-01-01

The variable stream control engine, VSCE-502B, was selected as the base engine, with the inverted flow engine concept selected as a backup. Critical component technologies were identified, and technology programs were formulated. Several engine configurations were defined on a preliminary basis to serve as demonstration vehicles for the various technologies. The different configurations present compromises in cost, technical risk, and technology return. Plans for possible variably cycle engine technology programs were formulated by synthesizing the technology requirements with the different demonstrator configurations.

5 CFR 2641.207 - One-year restriction on any former private sector assignee under the Information Technology...

Code of Federal Regulations, 2014 CFR

2014-01-01

... private sector assignee under the Information Technology Exchange Program representing, aiding, counseling... assignee under the Information Technology Exchange Program representing, aiding, counseling or assisting in... the Information Technology Exchange Program, 5 U.S.C. chapter 37, no former assignee shall knowingly...

5 CFR 2641.207 - One-year restriction on any former private sector assignee under the Information Technology...

Code of Federal Regulations, 2013 CFR

2013-01-01

... private sector assignee under the Information Technology Exchange Program representing, aiding, counseling... assignee under the Information Technology Exchange Program representing, aiding, counseling or assisting in... the Information Technology Exchange Program, 5 U.S.C. chapter 37, no former assignee shall knowingly...

5 CFR 2641.207 - One-year restriction on any former private sector assignee under the Information Technology...

Code of Federal Regulations, 2010 CFR

2010-01-01

... private sector assignee under the Information Technology Exchange Program representing, aiding, counseling... assignee under the Information Technology Exchange Program representing, aiding, counseling or assisting in... the Information Technology Exchange Program, 5 U.S.C. chapter 37, no former assignee shall knowingly...

5 CFR 2641.207 - One-year restriction on any former private sector assignee under the Information Technology...

Code of Federal Regulations, 2011 CFR

2011-01-01

... private sector assignee under the Information Technology Exchange Program representing, aiding, counseling... assignee under the Information Technology Exchange Program representing, aiding, counseling or assisting in... the Information Technology Exchange Program, 5 U.S.C. chapter 37, no former assignee shall knowingly...

5 CFR 2641.207 - One-year restriction on any former private sector assignee under the Information Technology...

Code of Federal Regulations, 2012 CFR

2012-01-01

... private sector assignee under the Information Technology Exchange Program representing, aiding, counseling... assignee under the Information Technology Exchange Program representing, aiding, counseling or assisting in... the Information Technology Exchange Program, 5 U.S.C. chapter 37, no former assignee shall knowingly...

Using Technology to Enhance an Automotive Program

ERIC Educational Resources Information Center

Ashton, Denis

2009-01-01

Denis Ashton uses technology in his automotive technology program at East Valley Institute of Technology (EVIT) to positively impact student outcomes. Ashton, the department chair for the automotive programs at EVIT, in Mesa, Arizona, says that using an interactive PowerPoint curriculum makes learning fun for students and provides immediate…

Using Technology To Promote Your Guidance and Counseling Program among Stake Holders.

ERIC Educational Resources Information Center

Sabella, Russell A.; Booker, Beverly L.

2003-01-01

Focuses on the use of technology to promote guidance and counseling programs among stakeholders. Details the significance of promoting comprehensive guidance and counseling programs and examples of technology tools used for persuasive communication. Discusses the advantages and disadvantages of using technology to promote a school counseling…

EERE Wind and Hydropower Technologies Program Technology Review (Deep Dive) for Under Secretaries Johnson and Koonin

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2009-09-01

September 4, 2009 presentation highlighting the Wind and Hydropower Program, addressing program goals and objectives, budgets, technology pathways, breakthroughs, and DOE solutions to market barriers.

EERE Wind and Hydropower Technologies Program Technology Review (Deep Dive) for Under Secretaries Johnson and Koonin

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCluer, Megan

2009-09-04

September 4, 2009 presentation highlighting the Wind and Hydropower Program, addressing program goals and objectives, budgets, technology pathways, breakthroughs, and DOE solutions to market barriers.

MLS student active learning within a "cloud" technology program.

PubMed

Tille, Patricia M; Hall, Heather

2011-01-01

In November 2009, the MLS program in a large public university serving a geographically large, sparsely populated state instituted an initiative for the integration of technology enhanced teaching and learning within the curriculum. This paper is intended to provide an introduction to the system requirements and sample instructional exercises used to create an active learning technology-based classroom. Discussion includes the following: 1.) define active learning and the essential components, 2.) summarize teaching methods, technology and exercises utilized within a "cloud" technology program, 3.) describe a "cloud" enhanced classroom and programming 4.) identify active learning tools and exercises that can be implemented into laboratory science programs, and 5.) describe the evaluation and assessment of curriculum changes and student outcomes. The integration of technology in the MLS program is a continual process and is intended to provide student-driven active learning experiences.

Space technology research plans

NASA Technical Reports Server (NTRS)

Hook, W. Ray

1992-01-01

Development of new technologies is the primary purpose of the Office of Aeronautics and Space Technology (OAST). OAST's mission includes the following two goals: (1) to conduct research to provide fundamental understanding, develop advanced technology and promote technology transfer to assure U.S. preeminence in aeronautics and to enhance and/or enable future civil space missions: and (2) to provide unique facilities and technical expertise to support national aerospace needs. OAST includes both NASA Headquarters operations as well as programmatic and institutional management of the Ames Research Center, the Langley Research Center and the Lewis Research Center. In addition. a considerable portion of OAST's Space R&T Program is conducted through the flight and science program field centers of NASA. Within OAST, the Space Technology Directorate is responsible for the planning and implementation of the NASA Space Research and Technology Program. The Space Technology Directorate's mission is 'to assure that OAST shall provide technology for future civil space missions and provide a base of research and technology capabilities to serve all national space goals.' Accomplishing this mission entails the following objectives: y Identify, develop, validate and transfer technology to: (1) increase mission safety and reliability; (2) reduce flight program development and operations costs; (3) enhance mission performance; and (4) enable new missions. Provide the capability to: (1) advance technology in critical disciplines; and (2) respond to unanticipated mission needs. In-space experiments are an integral part of OAST's program and provides for experimental studies, development and support for in-space flight research and validation of advanced space technologies. Conducting technology experiments in space is a valuable and cost effective way to introduce advanced technologies into flight programs. These flight experiments support both the R&T base and the focussed programs within OAST.

Transportation technology program: Strategic plan

NASA Astrophysics Data System (ADS)

1991-09-01

The purpose of this report is to define the technology program required to meet the transportation technology needs for current and future civil space missions. It is a part of an integrated plan, prepared by NASA in part in response to the Augustine Committee recommendations, to describe and advocate expanded and more aggressive efforts in the development of advanced space technologies. This expanded program will provide a technology basis for future space missions to which the U.S. aspires, and will help to regain technology leadership for the U.S. on a broader front. The six aspects of this integrated program/plan deal with focused technologies to support space sciences, exploration, transportation, platforms, and operations as well as provide a Research and Technology Base Program. This volume describes the technologies needed to support transportation systems, e.g., technologies needed for upgrades to current transportation systems and to provide reliable and efficient transportation for future space missions. The Office of Aeronautics, Exploration, and Technology (OAET) solicited technology needs from the major agency technology users and the aerospace industry community and formed a transportation technology team (appendix A) to develop a technology program to respond to those needs related to transportation technologies. This report addresses the results of that team activity. It is a strategic plan intended for use as a planning document rather than as a project management tool. It is anticipated that this document will be primarily utilized by research & technology (R&T) management at the various NASA Centers as well as by officials at NASA Headquarters and by industry in planning their corporate Independent Research and Development (IR&D) investments.

Transportation technology program: Strategic plan

NASA Technical Reports Server (NTRS)

1991-01-01

The purpose of this report is to define the technology program required to meet the transportation technology needs for current and future civil space missions. It is a part of an integrated plan, prepared by NASA in part in response to the Augustine Committee recommendations, to describe and advocate expanded and more aggressive efforts in the development of advanced space technologies. This expanded program will provide a technology basis for future space missions to which the U.S. aspires, and will help to regain technology leadership for the U.S. on a broader front. The six aspects of this integrated program/plan deal with focused technologies to support space sciences, exploration, transportation, platforms, and operations as well as provide a Research and Technology Base Program. This volume describes the technologies needed to support transportation systems, e.g., technologies needed for upgrades to current transportation systems and to provide reliable and efficient transportation for future space missions. The Office of Aeronautics, Exploration, and Technology (OAET) solicited technology needs from the major agency technology users and the aerospace industry community and formed a transportation technology team (appendix A) to develop a technology program to respond to those needs related to transportation technologies. This report addresses the results of that team activity. It is a strategic plan intended for use as a planning document rather than as a project management tool. It is anticipated that this document will be primarily utilized by research & technology (R&T) management at the various NASA Centers as well as by officials at NASA Headquarters and by industry in planning their corporate Independent Research and Development (IR&D) investments.

Healthcare technologies, quality improvement programs and hospital organizational culture in Canadian hospitals

PubMed Central

2013-01-01

Background Healthcare technology and quality improvement programs have been identified as a means to influence healthcare costs and healthcare quality in Canada. This study seeks to identify whether the ability to implement healthcare technology by a hospital was related to usage of quality improvement programs within the hospital and whether the culture within a hospital plays a role in the adoption of quality improvement programs. Methods A cross-sectional study of Canadian hospitals was conducted in 2010. The sample consisted of hospital administrators that were selected by provincial review boards. The questionnaire consisted of 3 sections: 20 healthcare technology items, 16 quality improvement program items and 63 culture items. Results Rasch model analysis revealed that a hierarchy existed among the healthcare technologies based upon the difficulty of implementation. The results also showed a significant relationship existed between the ability to implement healthcare technologies and the number of quality improvement programs adopted. In addition, culture within a hospital served a mediating role in quality improvement programs adoption. Conclusions Healthcare technologies each have different levels of difficulty. As a consequence, hospitals need to understand their current level of capability before selecting a particular technology in order to assess the level of resources needed. Further the usage of quality improvement programs is related to the ability to implement technology and the culture within a hospital. PMID:24119419

NASA's Physics of the Cosmos and Cosmic Origins programs manage Strategic Astrophysics Technology (SAT) development

NASA Astrophysics Data System (ADS)

Pham, Thai; Thronson, Harley; Seery, Bernard; Ganel, Opher

2016-07-01

The strategic astrophysics missions of the coming decades will help answer the questions "How did our universe begin and evolve?" "How did galaxies, stars, and planets come to be?" and "Are we alone?" Enabling these missions requires advances in key technologies far beyond the current state of the art. NASA's Physics of the Cosmos2 (PCOS), Cosmic Origins3 (COR), and Exoplanet Exploration Program4 (ExEP) Program Offices manage technology maturation projects funded through the Strategic Astrophysics Technology (SAT) program to accomplish such advances. The PCOS and COR Program Offices, residing at the NASA Goddard Space Flight Center (GSFC), were established in 2011, and serve as the implementation arm for the Astrophysics Division at NASA Headquarters. We present an overview of the Programs' technology development activities and the current technology investment portfolio of 23 technology advancements. We discuss the process for addressing community-provided technology gaps and Technology Management Board (TMB)-vetted prioritization and investment recommendations that inform the SAT program. The process improves the transparency and relevance of our technology investments, provides the community a voice in the process, and promotes targeted external technology investments by defining needs and identifying customers. The Programs' priorities are driven by strategic direction from the Astrophysics Division, which is informed by the National Research Council's (NRC) "New Worlds, New Horizons in Astronomy and Astrophysics" (NWNH) 2010 Decadal Survey report [1], the Astrophysics Implementation Plan (AIP) [2] as updated, and the Astrophysics Roadmap "Enduring Quests, Daring Visions" [3]. These priorities include technology development for missions to study dark energy, gravitational waves, X-ray and inflation probe science, and large far-infrared (IR) and ultraviolet (UV)/optical/IR telescopes to conduct imaging and spectroscopy studies. The SAT program is the Astrophysics Division's main investment method to mature technologies that will be identified by study teams set up to inform the 2020 Decadal Survey process on several large astrophysics mission concepts.

ADDENDUM TO SUPERFUND INNOVATIVE TECHNOLOGY EVALUATION PROGRAM TECHNOLOGY PROFILES, TENTH EDITION, VOLUME 1 - DEMONSTRATION PROGRAM

EPA Science Inventory

The Superfund Innovative Technology Evaluation (SITE) Program, now in its thirteenth year, is an integral part of EPA's research into alternative cleanup methods for hazardous waste sites around the nation. The SITE Program was created to encourage the development and routine us...

Electronic Engineering Technology Program Exit Examination as an ABET and Self-Assessment Tool

ERIC Educational Resources Information Center

Thomas, Gary; Darayan, Shahryar

2018-01-01

Every engineering, computing, and engineering technology program accredited by the Accreditation Board for Engineering and Technology (ABET) has formulated many and varied self-assessment methods. Methods used to assess a program for ABET accreditation and continuous improvement are for keeping programs current with academic and industrial…

THE SUPERFUND INNOVATIVE TECHNOLOGY EVALUATION PROGRAM: PROGRESS AND ACCOMPLISHMENTS - FISCAL YEAR 1990 A FOURTH REPORT TO CONGRESS

EPA Science Inventory

The SITE Program was the first major program for demonstrating and evaluating fullscale innovative treatment technologies at hazardous waste sites. Having concluded its fourth year, the SITE Program is recognized as a leading advocate of innovative technology development and comm...

Demographic Survey of Female Faculty in Technology Education Programs.

ERIC Educational Resources Information Center

Heidari, Farzin

A study was conducted to determine the general program information and the demographic status of female faculty in four-year technology education programs in the United States. Information was gathered through a literature review and a questionnaire mailed to all 70 technology education programs listed in the 1994 International Technology…

Successful Examples of Instructional Technology in Higher Education.

ERIC Educational Resources Information Center

Hortin, John A.

College programs considered to be successful in their use of instructional technology are described. The definition of instructional technology used to judge the media programs is as follows: a systematic approach to improve learning through media management, educational program development, and learning resources. Programs include the following:…

78 FR 8992 - Energy Conservation Program: Test Procedures for Residential Clothes Dryers

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-07

... Energy, Building Technologies Program, Mailstop EE-2J, 1000 Independence Avenue SW., Washington, DC 20585... Technologies Program, 6th Floor, 950 L'Enfant Plaza SW., Washington, DC 20024. Telephone: (202) 586-2945. If... and Renewable Energy, Building Technologies Program, EE-2J, 1000 Independence Avenue SW., Washington...

Raising awareness of assistive technology in older adults through a community-based, cooperative extension program.

PubMed

Sellers, Debra M; Markham, Melinda Stafford

2012-01-01

The Fashion an Easier Lifestyle with Assistive Technology (FELAT) curriculum was developed as a needs-based, community educational program provided through a state Cooperative Extension Service. The overall goal for participants was to raise awareness of assistive technology. Program evaluation included a postassessment and subsequent interview to determine short-term knowledge gain and longer term behavior change. The sample consisted of mainly older, married females. The FELAT program was effective at raising awareness and increasing knowledge of assistive technology, and for many participants, the program acted as a catalyst for planning to or taking action related to assistive technology.

ODIN system technology module library, 1972 - 1973

NASA Technical Reports Server (NTRS)

Hague, D. S.; Watson, D. A.; Glatt, C. R.; Jones, R. T.; Galipeau, J.; Phoa, Y. T.; White, R. J.

1978-01-01

ODIN/RLV is a digital computing system for the synthesis and optimization of reusable launch vehicle preliminary designs. The system consists of a library of technology modules in the form of independent computer programs and an executive program, ODINEX, which operates on the technology modules. The technology module library contains programs for estimating all major military flight vehicle system characteristics, for example, geometry, aerodynamics, economics, propulsion, inertia and volumetric properties, trajectories and missions, steady state aeroelasticity and flutter, and stability and control. A general system optimization module, a computer graphics module, and a program precompiler are available as user aids in the ODIN/RLV program technology module library.

Research and technology: 1994 annual report of the John F. Kennedy Space Center

NASA Technical Reports Server (NTRS)

1994-01-01

As the NASA Center responsible for assembly, checkout, servicing, launch, recovery, and operational support of Space Transportation System elements and payloads, the John F. Kennedy Space Center is placing increasing emphasis on its advanced technology development program. This program encompasses the efforts of the Engineering Development Directorate laboratories, most of the KSC operations contractors, academia, and selected commercial industries - all working in a team effort within their own areas of expertise. This edition of the Kennedy Space Center Research and Technology 1994 Annual Report covers efforts of all these contributors to the KSC advanced technology development program, as well as our technology transfer activities. The Technology Programs and Commercialization Office (DE-TPO), (407) 867-3017, is responsible for publication of this report and should be contacted for any desired information regarding the advanced technology program.

CSTI high capacity power. [Civil Space Technology Initiative

NASA Technical Reports Server (NTRS)

Winter, Jerry M.

1989-01-01

In FY-88, the Advanced Technology Program was incorporated into NASA's Civil Space Technology Initiative (CSTI). The CSTI Program was established to provide the foundation for technology development in automation and robotics, information, propulsion, and power. The CSTI High Capacity Power Program builds on the technology efforts of the SP-100 program, incorporates the previous NASA SP-100 Advanced Technology project, and provides a bridge to NASA Project Pathfinder. The elements of CSTI High Capacity Power development include Converrsion Systems, Thermal Management, Power Management, System Diagnostics, and Environmental Interactions. Technology advancement in all areas, including materials, is required to assure the high reliability and 7 to 10 year lifetime demanded for future space nuclear power systems.

Urban Rail Supporting Technology Program Fiscal Year 1975 - Year End Summary

DOT National Transportation Integrated Search

1975-12-01

The Urban Rail Supporting Technology Program is described for the 1975 fiscal year period. Important areas include program management, technical support and applications engineering, facilities development, test and evaluation, and technology develop...

75 FR 6627 - Broadband Technology Opportunities Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-10

... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration [Docket No. 0907141137-0079-07] RIN 0660-ZA28 Broadband Technology Opportunities Program AGENCY: National... policy and application procedures for the Broadband Technology Opportunities Program (BTOP) established...

Superfund and Technology Liaison Program Fact Sheet

EPA Pesticide Factsheets

The Superfund and Technology Liaison (STL) Program was established to facilitate regional access to ORD laboratories, provide technical support, and assist with the integration of science and technology into decision-making for hazardous waste programs.

Mississippi Curriculum Framework for Emergency Medical Technology--Basic (Program CIP: 51.0904). Emergency Medical Technology--Paramedic (Program CIP: 51.0904). Postsecondary Programs.

ERIC Educational Resources Information Center

Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the emergency medical technology (EMT) programs cluster. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline…

Let's get technical: Enhancing program evaluation through the use and integration of internet and mobile technologies.

PubMed

Materia, Frank T; Miller, Elizabeth A; Runion, Megan C; Chesnut, Ryan P; Irvin, Jamie B; Richardson, Cameron B; Perkins, Daniel F

2016-06-01

Program evaluation has become increasingly important, and information on program performance often drives funding decisions. Technology use and integration can help ease the burdens associated with program evaluation by reducing the resources needed (e.g., time, money, staff) and increasing evaluation efficiency. This paper reviews how program evaluators, across disciplines, can apply internet and mobile technologies to key aspects of program evaluation, which consist of participant registration, participant tracking and retention, process evaluation (e.g., fidelity, assignment completion), and outcome evaluation (e.g., behavior change, knowledge gain). In addition, the paper focuses on the ease of use, relative cost, and fit with populations. An examination on how these tools can be integrated to enhance data collection and program evaluation is discussed. Important limitations of and considerations for technology integration, including the level of technical skill, cost needed to integrate various technologies, data management strategies, and ethical considerations, are highlighted. Lastly, a case study of technology use in an evaluation conducted by the Clearinghouse for Military Family Readiness at Penn State is presented and illustrates how technology integration can enhance program evaluation. Copyright © 2016 Elsevier Ltd. All rights reserved.

A Conceptual Methodology for Assessing Acquisition Requirements Robustness against Technology Uncertainties

NASA Astrophysics Data System (ADS)

Chou, Shuo-Ju

2011-12-01

In recent years the United States has shifted from a threat-based acquisition policy that developed systems for countering specific threats to a capabilities-based strategy that emphasizes the acquisition of systems that provide critical national defense capabilities. This shift in policy, in theory, allows for the creation of an "optimal force" that is robust against current and future threats regardless of the tactics and scenario involved. In broad terms, robustness can be defined as the insensitivity of an outcome to "noise" or non-controlled variables. Within this context, the outcome is the successful achievement of defense strategies and the noise variables are tactics and scenarios that will be associated with current and future enemies. Unfortunately, a lack of system capability, budget, and schedule robustness against technology performance and development uncertainties has led to major setbacks in recent acquisition programs. This lack of robustness stems from the fact that immature technologies have uncertainties in their expected performance, development cost, and schedule that cause to variations in system effectiveness and program development budget and schedule requirements. Unfortunately, the Technology Readiness Assessment process currently used by acquisition program managers and decision-makers to measure technology uncertainty during critical program decision junctions does not adequately capture the impact of technology performance and development uncertainty on program capability and development metrics. The Technology Readiness Level metric employed by the TRA to describe program technology elements uncertainties can only provide a qualitative and non-descript estimation of the technology uncertainties. In order to assess program robustness, specifically requirements robustness, against technology performance and development uncertainties, a new process is needed. This process should provide acquisition program managers and decision-makers with the ability to assess or measure the robustness of program requirements against such uncertainties. A literature review of techniques for forecasting technology performance and development uncertainties and subsequent impacts on capability, budget, and schedule requirements resulted in the conclusion that an analysis process that coupled a probabilistic analysis technique such as Monte Carlo Simulations with quantitative and parametric models of technology performance impact and technology development time and cost requirements would allow the probabilities of meeting specific constraints of these requirements to be established. These probabilities of requirements success metrics can then be used as a quantitative and probabilistic measure of program requirements robustness against technology uncertainties. Combined with a Multi-Objective Genetic Algorithm optimization process and computer-based Decision Support System, critical information regarding requirements robustness against technology uncertainties can be captured and quantified for acquisition decision-makers. This results in a more informed and justifiable selection of program technologies during initial program definition as well as formulation of program development and risk management strategies. To meet the stated research objective, the ENhanced TEchnology Robustness Prediction and RISk Evaluation (ENTERPRISE) methodology was formulated to provide a structured and transparent process for integrating these enabling techniques to provide a probabilistic and quantitative assessment of acquisition program requirements robustness against technology performance and development uncertainties. In order to demonstrate the capabilities of the ENTERPRISE method and test the research Hypotheses, an demonstration application of this method was performed on a notional program for acquiring the Carrier-based Suppression of Enemy Air Defenses (SEAD) using Unmanned Combat Aircraft Systems (UCAS) and their enabling technologies. The results of this implementation provided valuable insights regarding the benefits and inner workings of this methodology as well as its limitations that should be addressed in the future to narrow the gap between current state and the desired state.

Summary of Pellet Technology Program Activities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gebhart, III, Gerald E.; Baylor, Larry R.; Bell, Gary L.

This report summarizes the activities and budget information of ORNL’s pellet technology program from the start of FY2014 through FY2017. Cost summaries are broken down by year and spending category. Milestone activities are outlined and described by year and further described in the project narrative. The project narrative outlines the main pellet injection technology advances enabled by the pellet technology program. A list of published research products is included, along with biographies of personnel involved. This document was prepared in support of the April 24, 2018, review of the pellet technology program at ORNL.

Final Report: Fire Prevention, Detection, and Suppression Project, Exploration Technology Development Program

NASA Technical Reports Server (NTRS)

Ruff, Gary A.

2011-01-01

The Fire Prevention, Detection, and Suppression (FPDS) project is a technology development effort within the Exploration Technology Development Program of the Exploration System Missions Directorate (ESMD) that addresses all aspects of fire safety aboard manned exploration systems. The overarching goal for work in the FPDS area is to develop technologies that will ensure crew health and safety on exploration missions by reducing the likelihood of a fire, or, if one does occur, minimizing the risk to the crew, mission, or system. This is accomplished by addressing the areas of (1) fire prevention and material flammability, (2) fire signatures and detection, and (3) fire suppression and response. This report describes the outcomes of this project from the formation of the Exploration Technology Development Program (ETDP) in October 2005 to September 31, 2010 when the Exploration Technology Development Program was replaced by the Enabling Technology Development and Demonstration Program. NASA s fire safety work will continue under this new program and will build upon the accomplishments described herein.

Making Technology Ready: Integrated Systems Health Management

NASA Technical Reports Server (NTRS)

Malin, Jane T.; Oliver, Patrick J.

2007-01-01

This paper identifies work needed by developers to make integrated system health management (ISHM) technology ready and by programs to make mission infrastructure ready for this technology. This paper examines perceptions of ISHM technologies and experience in legacy programs. Study methods included literature review and interviews with representatives of stakeholder groups. Recommendations address 1) development of ISHM technology, 2) development of ISHM engineering processes and methods, and 3) program organization and infrastructure for ISHM technology evolution, infusion and migration.

Implementing a Computer/Technology Endorsement in a Classroom Technology Master's Program.

ERIC Educational Resources Information Center

Brownell, Gregg; O'Bannon, Blanche; Brownell, Nancy

In the spring of 1998, the Master's program in Classroom Technology at Bowling Green State University (Ohio) was granted conditional approval to grant, as part of the program, the new State of Ohio Department of Education computer/technology endorsement. This paper briefly describes Ohio's change from certification to licensure, the removal of…

Pathways to Commercial Success. Technologies and Products Supported by the Fuel Cell Technologies Program - 2012

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

This FY 2012 report updates the results of an effort to identify and characterize commercial and near-commercial (emerging) technologies and products that benefited from the support of the Fuel Cell Technologies Program and its predecessor programs within DOE's Office of Energy Efficiency and Renewable Energy.

Pathways to Commercial Success. Technologies and Products Supported by the Fuel Cell Technologies Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

none,

This FY 2011 report updates the results of an effort to identify and characterize commercial and near-commercial (emerging) technologies and products that benefited from the support of the Fuel Cell Technologies Program and its predecessor programs within DOE's Office of Energy Efficiency and Renewable Energy.

Improving Outcome Assessment in Information Technology Program Accreditation

ERIC Educational Resources Information Center

Goda, Bryan S.; Reynolds, Charles

2010-01-01

As of March 2010, there were fourteen Information Technology programs accredited by the Accreditation Board for Engineering and Technology, known as ABET, Inc (ABET Inc. 2009). ABET Inc. is the only recognized institution for the accreditation of engineering, computing, and technology programs in the U.S. There are currently over 128 U.S. schools…

Technology and Literacy: 21st Century Library Programming for Children and Teens

ERIC Educational Resources Information Center

Nelson, Jennifer; Braafladt, Keith

2012-01-01

Technology may not be a magic wand, but innovative technology programming can genuinely help children become adept at navigating our increasingly wired world while also helping them develop deductive reasoning, math, and other vital literacy skills. One of the simplest and most powerful tools for technology-based public library programming is…

Biomedical Technology. Innovations: The Social Consequences of Science and Technology Program.

ERIC Educational Resources Information Center

McInerney, Joseph D.; And Others

This module is part of an interdisciplinary program designed to educate the general citizenry regarding the issues of science/technology/society that have important consequences for both present and future social policies. Specifically, the program provides an opportunity for students to assess the effects of selected technological innovations in…

A Model for Integrating New Technologies into Pre-Service Teacher Training Programs Ajman University (A Case Study)

ERIC Educational Resources Information Center

Shaqour, Ali Zuhdi H.

2005-01-01

This study introduces a "Technology Integration Model" for a learning environment utilizing constructivist learning principles and integrating new technologies namely computers and the Internet into pre-service teacher training programs. The technology integrated programs and learning environments may assist learners to gain experiences…

The Impact of an Online Collaborative Learning Program on Students' Attitude towards Technology

ERIC Educational Resources Information Center

Magen-Nagar, Noga; Shonfeld, Miri

2018-01-01

This quantitative research examined the contribution of an Online Collaborative Learning (OCL) program on attitudes towards technology in terms of technological anxiety, self-confidence and technology orientation among M.Ed. students. The advanced online collaborative program was implemented at two teacher training colleges in Israel for a period…

Environmental restoration and waste management: Robotics technology development program: Robotics 5-year program plan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This plan covers robotics Research, Development, Demonstration, Testing and Evaluation activities in the Program for the next five years. These activities range from bench-scale R D to full-scale hot demonstrations at DOE sites. This plan outlines applications of existing technology to near-term needs, the development and application of enhanced technology for longer-term needs, and initiation of advanced technology development to meet those needs beyond the five-year plan. The objective of the Robotic Technology Development Program (RTDP) is to develop and apply robotics technologies that will enable Environmental Restoration and Waste Management (ER WM) operations at DOE sites to be safer,more » faster and cheaper. Five priority DOE sites were visited in March 1990 to identify needs for robotics technology in ER WM operations. This 5-Year Program Plan for the RTDP detailed annual plans for robotics technology development based on identified needs. In July 1990 a forum was held announcing the robotics program. Over 60 organizations (industrial, university, and federal laboratory) made presentations on their robotics capabilities. To stimulate early interactions with the ER WM activities at DOE sites, as well as with the robotics community, the RTDP sponsored four technology demonstrations related to ER WM needs. These demonstrations integrated commercial technology with robotics technology developed by DOE in support of areas such as nuclear reactor maintenance and the civilian reactor waste program. 2 figs.« less

Marine Propulsion Technology Program Meets the Demand

ERIC Educational Resources Information Center

Fowler, Howard G.

1974-01-01

The marine technology program cluster at Florida Keys Community College is described. Technicians are trained to maintain and repair engines and selected marine accessories through a marine propulsion technology curriculum (certificate program and associate in science degree). (EA)

Educational Leadership.

ERIC Educational Resources Information Center

Tollett, John R., Ed.

This document contains the following papers on educational leadership programs and technology: (1) "Technology Standards for School Administrators: Implications for Administrator Preparation Programs" (Warren C. Hope, Bernadette Kelley, and Janet A. Guyden); (2) "Information Technology and the Transformation of Leadership Preparation Programs: A…

75 FR 10464 - Broadband Technology Opportunities Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-08

... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration [Docket Number 0907141137-0119-08] RIN 0660-ZA28 Broadband Technology Opportunities Program AGENCY: National... Infrastructure (CCI) projects under the Broadband Technology Opportunities Program (BTOP) is extended until 5:00...

75 FR 14131 - Broadband Technology Opportunities Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-24

... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration [Docket Number: 0907141137-0154-09] RIN 0660-ZA28 Broadband Technology Opportunities Program AGENCY: National... under the Broadband Technology Opportunities Program (BTOP) is extended until 10 p.m. Eastern Daylight...

Implementing Technology with Industrial Community: The SBIR Example

NASA Technical Reports Server (NTRS)

Ghuman, Parminder

2005-01-01

The Earth-Sun system Technology Office (ESTO) works with Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs to supplement its own technology development program. The SBIR/STTR program is a highly competitive program that encourages small business to explore their technological potential to fulfill technology needs identified by ESTO. SBIR program has three phases. The Phase 1 contracts last for 6 months with a maximum funding of $70,000, and Phase 2 contracts last for 24 months with a maximum funding of $600,000. For Phase 3, the small business must find funding in the private sector or other non-SBIR federal agency funding. During this phase ESTO evaluates Phase 2 graduates and selects those that need to be further developed for airborne or spaceflight demonstration and provides funding. This paper will discuss the all three phases in and role of ESTO in this program.

NASA Goddard Thermal Technology Overview 2017

NASA Technical Reports Server (NTRS)

Butler, Dan; Swanson, Ted

2017-01-01

This presentation summarizes the current plans and efforts at NASA Goddard to develop new thermal control technology for anticipated future missions. It will also address some of the programmatic developments currently underway at NASA, especially with respect to the NASA Technology Development Program. The effects of the recently enacted FY 17 NASA budget, which includes a sizeable increase, will also be addressed. While funding for basic technology development is still tight, significant efforts are being made in direct support of flight programs. Thermal technology Implementation on current flight programs will be reviewed, and the recent push for CubeSat mission development will also be addressed. Many of these technologies also have broad applicability to DOD (Dept. of Defense), DOE (Dept. of the Environment), and commercial programs. Partnerships have been developed with the Air Force, Navy, and various universities to promote technology development. In addition, technology development activities supported by internal research and development (IRAD) program and the Small Business Innovative Research (SBIR) program are reviewed in this presentation. Specific technologies addressed include; two-phase systems applications and issues on NASA missions, latest developments of electro-hydrodynamically pumped systems, Atomic Layer Deposition (ALD), Micro-scale Heat Transfer, and various other research activities.

NASA Goddard Thermal Technology Overview 2016

NASA Technical Reports Server (NTRS)

Butler, Dan; Swanson, Ted

2016-01-01

This presentation summarizes the current plans and efforts at NASA Goddard to develop new thermal control technology for anticipated future missions. It will also address some of the programmatic developments currently underway at NASA, especially with respect to the NASA Technology Development Program. The effects of the recently enacted FY 16 NASA budget, which includes a sizeable increase, will also be addressed. While funding for basic technology development is still tight, significant efforts are being made in direct support of flight programs. Thermal technology implementation on current flight programs will be reviewed, and the recent push for Cube-sat mission development will also be addressed. Many of these technologies also have broad applicability to DOD, DOE, and commercial programs. Partnerships have been developed with the Air Force, Navy, and various universities to promote technology development. In addition, technology development activities supported by internal research and development (IRAD) program and the Small Business Innovative Research (SBIR) program are reviewed in this presentation. Specific technologies addressed include; two-phase systems applications and issues on NASA missions, latest developments of electro-hydrodynamically pumped systems, Atomic Layer Deposition (ALD), Micro-scale Heat Transfer, and various other research activities.

NASA's Commercial Communication Technology Program

NASA Technical Reports Server (NTRS)

Bagwell, James W.

1998-01-01

Various issues associated with "NASA's Commercial Communication Technology Program" are presented in viewgraph form. Specific topics include: 1) Coordination/Integration of government program; 2) Achievement of seamless interoperable satellite and terrestrial networks; 3) Establishment of program to enhance Satcom professional and technical workforce; 4) Precompetitive technology development; and 5) Effective utilization of spectrum and orbit assets.

Development of a Curriculum in Laser Technology. Final Report.

ERIC Educational Resources Information Center

Wasserman, William J.

A Seattle Central Community College project visited existing programs, surveyed need, and developed a curriculum for a future program in Laser-Electro-Optics (LEO) Technology. To establish contacts and view successful programs, project staff made visits to LEO technology programs at San Jose City College and Texas State Technical Institute, Center…

Report on High Technology Programs in Illinois Public Community Colleges.

ERIC Educational Resources Information Center

Illinois Community Coll. Board, Springfield.

Survey results are presented from a study of the steps being taken by the 52 Illinois public community colleges to develop and provide programs in high technology fields. First, high technology programs are defined as those occupational programs that educate and train individuals to operate, maintain, and/or repair micro-electronic or computerized…

Parental Decision Making about Technology and Quality in Child Care Programs

ERIC Educational Resources Information Center

Rose, Katherine K.; Vittrup, Brigitte; Leveridge, Tinney

2013-01-01

Background: This study investigated parental decision making about non-parental child care programs based on the technological and quality components of the program, both child-focused and parent-focused. Child-focused variables related to children's access to technology such as computers, educational television programming, and the internet.…

34 CFR 403.30 - What documents must a State submit to receive a grant?

Code of Federal Regulations, 2010 CFR

2010-07-01

...) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE VOCATIONAL AND APPLIED TECHNOLOGY... Technology Education Program on the basis of program years that coincide with program years under section 104... Technology Education Program. (Approved by the Office of Management and Budget under Control No. 1830-0029...

Vehicle Technologies and Fuel Cell Technologies Program: Prospective Benefits Assessment Report for Fiscal Year 2016

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stephens, T. S.; Taylor, C. H.; Moore, J. S.

Under a diverse set of programs, the Vehicle Technologies and Fuel Cell Technologies offices of DOE’s Office of Energy Efficiency and Renewable Energy invest in research, development, demonstration, and deployment of advanced vehicle, hydrogen production, delivery and storage, and fuel cell technologies. This report estimates the benefits of successfully developing and deploying these technologies (a “Program Success” case) relative to a base case (the “No Program” case). The Program Success case represents the future with completely successful deployment of Vehicle Technologies Office (VTO) and Fuel Cell Technologies Office (FCTO) technologies. The No Program case represents a future in which theremore » is no contribution after FY 2016 by the VTO or FCTO to these technologies. The benefits of advanced vehicle, hydrogen production, delivery and storage, and fuel cell technologies were estimated on the basis of differences in fuel use, primary energy use, and greenhouse gas (GHG) emissions from light-, medium- and heavy-duty vehicles, including energy and emissions from fuel production, between the base case and the Program Success case. Improvements in fuel economy of various vehicle types, growth in the stock of fuel cell vehicles and other advanced technology vehicles, and decreased GHG intensity of hydrogen production and delivery in the Program Success case over the No Program case were projected to result in savings in petroleum use and GHG emissions. Benefits were disaggregated by individual program technology areas, which included the FCTO program and the VTO subprograms of batteries and electric drives; advanced combustion engines; fuels and lubricants; materials (for reduction in vehicle mass, or “lightweighting”); and, for medium- and heavy-duty vehicles, reduction in rolling and aerodynamic resistance. Projections for the Program Success case indicate that by 2035, the average fuel economy of on-road, light-duty vehicle stock could be 47% to 76% higher than in the No Program case. On-road medium- and heavy-duty vehicle stock could be as much as 39% higher. The resulting petroleum savings in 2035 were estimated to be as high as 3.1 million barrels per day, and reductions in GHG emissions were estimated to be as high as 500 million metric tons of CO2 equivalent per year. The benefits of continuing to invest government resources in advanced vehicle and fuel cell technologies would have significant economic value in the U.S. transportation sector and reduce its dependency on oil and its vulnerability to oil price shocks.« less

Mass Balance, Beneficial Use Products, and Cost Comparisons of Four Sediment Treatment Technologies Near Commercialization

DTIC Science & Technology

2011-03-01

Superfund Innovative Technology Evaluation Program (SITE) • Assessment and Remediation of Contaminated Sediment Program (ARCS) • Contaminated Sediment...Agency (USEPA). 1994. Assessment and Remediation of Contaminated Sediments (ARCS) Program Remediation Guidance Document. EPA/905/R-94/003. Chicago, IL...conducted under one of the four following programs: • Superfund Innovative Technology Evaluation (SITE) Program • Assessment and Remediation of

Funding and Strategic Alignment Guidance for Infusing Small Business Innovation Research Technology into NASA Programs Associated with the Aeronautics Research Mission Directorate

NASA Technical Reports Server (NTRS)

Nguyen, Hung D.; Steele, Gynelle C.

2015-01-01

This report is intended to help NASA program and project managers incorporate Small Business Innovation Research/Small Business Technology Transfer (SBIR/STTR) technologies that have gone through Phase II of the SBIR program into NASA Aeronautics and Mission Directorate (ARMD) programs. Other Government and commercial program managers can also find this information useful.

DOE Solar Energy Technologies Program FY 2005 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The DOE Solar Energy Technologies Program FY 2005 Annual Report chronicles the R&D results of the U.S. Department of Energy Solar Energy Technologies Program for Fiscal Year 2005. In particular, the report describes R&D performed by the Program?s national laboratories (National Renewable Energy Laboratory, Sandia National Laboratories, Oak Ridge National Laboratory, and Brookhaven National Laboratory) and university and industry partners.

Innovative quantum technologies for microgravity fundamental physics and biological research

NASA Technical Reports Server (NTRS)

Kierk, I.; Israelsson, U.; Lee, M.

2001-01-01

This paper presents a new technology program, within the fundamental physics research program, focusing on four quantum technology areas: quantum atomics, quantum optics, space superconductivity and quantum sensor technology, and quantum fluid based sensor and modeling technology.

45 CFR 170.490 - Sunset of the temporary certification program.

Code of Federal Regulations, 2011 CFR

2011-10-01

....490 Section 170.490 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Temporary Certification Program for HIT...

45 CFR 170.490 - Sunset of the temporary certification program.

Code of Federal Regulations, 2013 CFR

2013-10-01

....490 Section 170.490 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Temporary Certification Program for HIT...

45 CFR 170.490 - Sunset of the temporary certification program.

Code of Federal Regulations, 2010 CFR

2010-10-01

....490 Section 170.490 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Temporary Certification Program for HIT...

45 CFR 170.490 - Sunset of the temporary certification program.

Code of Federal Regulations, 2012 CFR

2012-10-01

....490 Section 170.490 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Temporary Certification Program for HIT...

45 CFR 170.490 - Sunset of the temporary certification program.

Code of Federal Regulations, 2014 CFR

2014-10-01

....490 Section 170.490 Public Welfare Department of Health and Human Services HEALTH INFORMATION TECHNOLOGY HEALTH INFORMATION TECHNOLOGY STANDARDS, IMPLEMENTATION SPECIFICATIONS, AND CERTIFICATION CRITERIA AND CERTIFICATION PROGRAMS FOR HEALTH INFORMATION TECHNOLOGY Temporary Certification Program for HIT...

ENVIRONMENTAL TECHNOLOGY VERIFICATION (ETV) PROGRAM CASE STUDIES: DEMONSTRATING PROGRAM OUTCOMES

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) Environmental Technology Verification (ETV) Program evaluates the performance of innovative air, water, pollution prevention and monitoring technologies that have the potential to improve human health and the environment. This bookle...

Sensors 2000! Program: Advanced Biosensor and Measurement Systems Technologies for Spaceflight Research and Concurrent, Earth-Based Applications

NASA Technical Reports Server (NTRS)

Hines, J.

1999-01-01

Sensors 2000! (S2K!) is a specialized, integrated projects team organized to provide focused, directed, advanced biosensor and bioinstrumentation systems technology support to NASA's spaceflight and ground-based research and development programs. Specific technology thrusts include telemetry-based sensor systems, chemical/ biological sensors, medical and physiological sensors, miniaturized instrumentation architectures, and data and signal processing systems. A concurrent objective is to promote the mutual use, application, and transition of developed technology by collaborating in academic-commercial-govemment leveraging, joint research, technology utilization and commercialization, and strategic partnering alliances. Sensors 2000! is organized around three primary program elements: Technology and Product Development, Technology infusion and Applications, and Collaborative Activities. Technology and Product Development involves development and demonstration of biosensor and biotelemetry systems for application to NASA Space Life Sciences Programs; production of fully certified spaceflight hardware and payload elements; and sensor/measurement systems development for NASA research and development activities. Technology Infusion and Applications provides technology and program agent support to identify available and applicable technologies from multiple sources for insertion into NASA's strategic enterprises and initiatives. Collaborative Activities involve leveraging of NASA technologies with those of other government agencies, academia, and industry to concurrently provide technology solutions and products of mutual benefit to participating members.

Spinoff 1998

NASA Technical Reports Server (NTRS)

1998-01-01

In 1958, a Congressional Mandate directed the National Aeronautics and Space Agency to ensure for the widest possible dissemination of its research and development results. Thus, the Scientific and Technical Information (STI) Program was born. While this program addressed mostly the timely dissemination of information to NASA, NASA contractors, other government agencies, and the public, technologies were identified that were clearly transferable and applicable to industry for additional use in the development of commercial products and services. Such considerations spun off the Technology Utilization Program. The very successful program went through several name changes and is today called the NASA Commercial Technology Program. The changes that have occurred over time are not only name changes, but program changes that have dramatically altered the philosophy, mission, and goal of the program. It has been identified that a more intense and proactive outreach effort within the program is necessary in order to make the newest and latest technologies available to industry now-at the time the technology is actually developed. The NASA Commercial Technology Network (NCTN), its interaction with industry at all levels through a large network of organizations and offices, is contributing to the success of small, medium, and large U.S. businesses to remain globally competitive. At the same time, new products and services derived from the transfer and application of NASA technology benefit everyone. This publication includes the following: Aerospace research and development - NASA headquarters and centers. Technology transfer and commercialization. Commercial benefits - spinoffs.NASA success and education. NASA commercial technology network.

Rover and Telerobotics Technology Program

NASA Technical Reports Server (NTRS)

Weisbin, Charles R.

1998-01-01

The Jet Propulsion Laboratory's (JPL's) Rover and Telerobotics Technology Program, sponsored by the National Aeronautics and Space Administration (NASA), responds to opportunities presented by NASA space missions and systems, and seeds commerical applications of the emerging robotics technology. The scope of the JPL Rover and Telerobotics Technology Program comprises three major segments of activity: NASA robotic systems for planetary exploration, robotic technology and terrestrial spin-offs, and technology for non-NASA sponsors. Significant technical achievements have been reached in each of these areas, including complete telerobotic system prototypes that have built and tested in realistic scenarios relevant to prospective users. In addition, the program has conducted complementary basic research and created innovative technology and terrestrial applications, as well as enabled a variety of commercial spin-offs.

The NASA controls-structures interaction technology program

NASA Technical Reports Server (NTRS)

Newsom, Jerry R.; Layman, W. E.; Waites, H. B.; Hayduk, R. J.

1990-01-01

The interaction between a flexible spacecraft structure and its control system is commonly referred to as controls-structures interaction (CSI). The CSI technology program is developing the capability and confidence to integrate the structure and control system, so as to avoid interactions that cause problems and to exploit interactions to increase spacecraft capability. A NASA program has been initiated to advance CSI technology to a point where it can be used in spacecraft design for future missions. The CSI technology program is a multicenter program utilizing the resources of the NASA Langley Research Center (LaRC), the NASA Marshall Space Flight Center (MSFC), and the NASA Jet Propulsion Laboratory (JPL). The purpose is to describe the current activities, results to date, and future activities of the NASA CSI technology program.

Energy Efficiency and Renewable Energy Program. Bibliography, 1993 edition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vaughan, K.H.

1993-06-01

The Bibliography contains listings of publicly available reports, journal articles, and published conference papers sponsored by the DOE Office of Energy Efficiency and Renewable Energy and published between 1987 and mid-1993. The topics of Bibliography include: analysis and evaluation; building equipment research; building thermal envelope systems and materials; district heating; residential and commercial conservation program; weatherization assistance program; existing buildings research program; ceramic technology project; alternative fuels and propulsion technology; microemulsion fuels; industrial chemical heat pumps; materials for advanced industrial heat exchangers; advanced industrial materials; tribology; energy-related inventions program; electric energy systems; superconducting technology program for electric energy systems; thermalmore » energy storage; biofuels feedstock development; biotechnology; continuous chromatography in multicomponent separations; sensors for electrolytic cells; hydropower environmental mitigation; environmental control technology; continuous fiber ceramic composite technology.« less

76 FR 1261 - Establishment of the Permanent Certification Program for Health Information Technology

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-07

...This final rule establishes a permanent certification program for the purpose of certifying health information technology (HIT). This final rule is issued pursuant to the authority granted to the National Coordinator for Health Information Technology (the National Coordinator) by section 3001(c)(5) of the Public Health Service Act (PHSA), as added by the Health Information Technology for Economic and Clinical Health (HITECH) Act. The permanent certification program will eventually replace the temporary certification program that was previously established by a final rule. The National Coordinator will use the permanent certification program to authorize organizations to certify electronic health record (EHR) technology, such as Complete EHRs and/or EHR Modules. The permanent certification program could also be expanded to include the certification of other types of HIT.

Innovative Partnerships Program Accomplishments: 2009-2010 at NASA's Kennedy Space Center

NASA Technical Reports Server (NTRS)

Makufka, David

2010-01-01

This document reports on the accomplishments of the Innovative Partnerships Program during the two years of 2009 and 2010. The mission of the Innovative Partnerships Program is to provide leveraged technology alternatives for mission directorates, programs, and projects through joint partnerships with industry, academia, government agencies, and national laboratories. As outlined in this accomplishments summary, the IPP at NASA's Kennedy Space Center achieves this mission via two interdependent goals: (1) Infusion: Bringing external technologies and expertise into Kennedy to benefit NASA missions, programs, and projects (2) Technology Transfer: Spinning out space program technologies to increase the benefits for the nation's economy and humanity

Space Station Engineering and Technology Development. Proceedings of the Panel on Program Performance and Onboard Mission Control

NASA Technical Reports Server (NTRS)

1985-01-01

An ad-hoc committee was asked to review the following questions relevant to the space station program: (1) onboard maintainability and repair; (2) in-space research and technology program and facility plans; (3) solar thermodynamic research and technology development program planning; (4) program performance (cost estimating, management, and cost avoidance); (5) onboard versus ground-based mission control; and (6) technology development road maps from IOC to the growth station. The objective of these new assignments is to provide NASA with advice on ways and means for improving the content, performance, and/or effectiveness of these elements of the space station program.

Evaluation of spacecraft technology programs (effects on communication satellite business ventures), volume 1

NASA Technical Reports Server (NTRS)

Greenburg, J. S.; Gaelick, C.; Kaplan, M.; Fishman, J.; Hopkins, C.

1985-01-01

Commercial organizations as well as government agencies invest in spacecraft (S/C) technology programs that are aimed at increasing the performance of communications satellites. The value of these programs must be measured in terms of their impacts on the financial performane of the business ventures that may ultimately utilize the communications satellites. An economic evaluation and planning capability was developed and used to assess the impact of NASA on-orbit propulsion and space power programs on typical fixed satellite service (FSS) and direct broadcast service (DBS) communications satellite business ventures. Typical FSS and DBS spin and three-axis stabilized spacecraft were configured in the absence of NASA technology programs. These spacecraft were reconfigured taking into account the anticipated results of NASA specified on-orbit propulsion and space power programs. In general, the NASA technology programs resulted in spacecraft with increased capability. The developed methodology for assessing the value of spacecraft technology programs in terms of their impact on the financial performance of communication satellite business ventures is described. Results of the assessment of NASA specified on-orbit propulsion and space power technology programs are presented for typical FSS and DBS business ventures.

Evaluation of spacecraft technology programs (effects on communication satellite business ventures), volume 1

NASA Astrophysics Data System (ADS)

Greenburg, J. S.; Gaelick, C.; Kaplan, M.; Fishman, J.; Hopkins, C.

1985-09-01

Commercial organizations as well as government agencies invest in spacecraft (S/C) technology programs that are aimed at increasing the performance of communications satellites. The value of these programs must be measured in terms of their impacts on the financial performane of the business ventures that may ultimately utilize the communications satellites. An economic evaluation and planning capability was developed and used to assess the impact of NASA on-orbit propulsion and space power programs on typical fixed satellite service (FSS) and direct broadcast service (DBS) communications satellite business ventures. Typical FSS and DBS spin and three-axis stabilized spacecraft were configured in the absence of NASA technology programs. These spacecraft were reconfigured taking into account the anticipated results of NASA specified on-orbit propulsion and space power programs. In general, the NASA technology programs resulted in spacecraft with increased capability. The developed methodology for assessing the value of spacecraft technology programs in terms of their impact on the financial performance of communication satellite business ventures is described. Results of the assessment of NASA specified on-orbit propulsion and space power technology programs are presented for typical FSS and DBS business ventures.

General Aviation Propulsion

NASA Technical Reports Server (NTRS)

1980-01-01

Programs exploring and demonstrating new technologies in general aviation propulsion are considered. These programs are the quiet, clean, general aviation turbofan (QCGAT) program; the general aviation turbine engine (GATE) study program; the general aviation propeller technology program; and the advanced rotary, diesel, and reciprocating engine programs.

Human Reproduction: Social and Technological Aspects. Innovations: The Social Consequences of Science and Technology Program.

ERIC Educational Resources Information Center

McConnell, Mary C.; And Others

This module is part of an interdisciplinary program designed to educate the general citizenry regarding the issues of science/technology/society that have important consequences for both present and future social policies. Specifically, the program provides an opportunity for students to assess the effects of selected technological innovations in…

One-to-One Laptop Teacher Education: Does Involvement Affect Candidate Technology Skills and Dispositions?

ERIC Educational Resources Information Center

Donovan, Loretta; Green, Tim; Hansen, Laurie E.

2012-01-01

This study compares teacher candidates' initial and changed beliefs, dispositions, and uses of technology in two credential program models: a one-to-one laptop program with ubiquitous technology use and a traditional credential program in which students are expected to have specific technology experiences and requirements in each course (a model…

High area rate reconnaissance (HARR) and mine reconnaissance/hunter (MR/H) exploratory development programs

NASA Astrophysics Data System (ADS)

Lathrop, John D.

1995-06-01

This paper describes the sea mine countermeasures developmental context, technology goals, and progress to date of the two principal Office of Naval Research exploratory development programs addressing sea mine reconnaissance and minehunting technology development. The first of these programs, High Area Rate Reconnaissance, is developing toroidal volume search sonar technology, sidelooking sonar technology, and associated signal processing technologies (motion compensation, beamforming, and computer-aided detection and classification) for reconnaissance and hunting against volume mines and proud bottom mines from 21-inch diameter vehicles operating in deeper waters. The second of these programs, Amphibious Operation Area Mine Reconnaissance/Hunter, is developing a suite of sensor technologies (synthetic aperture sonar, ahead-looking sonar, superconducting magnetic field gradiometer, and electro-optic sensor) and associated signal processing technologies for reconnaissance and hunting against all mine types (including buried mines) in shallow water and very shallow water from 21-inch diameter vehicles. The technologies under development by these two programs must provide excellent capabilities for mine detection, mine classification, and discrimination against false targets.

Integrating the Department of Defense Military Services’ Technology Development Programs to Improve Time, Cost, and Technical Quality Parameters

DTIC Science & Technology

2007-03-01

the DoD in general and across the SR, DD(X), and FCS programs in particular. The findings of this study show that through careful planning and...FCS programs in particular. The findings of this study show that through careful planning and coordinated technology transition, DoD acquisition...careful planning and coordinated technology transition, DoD acquisition programs can indeed leverage the technology development efforts of the three

NASA's Physics of the Cosmos and Cosmic Origins technology development programs

NASA Astrophysics Data System (ADS)

Clampin, Mark; Pham, Thai

2014-07-01

NASA's Physics of the Cosmos (PCOS) and Cosmic Origins (COR) Program Offices, established in 2011, reside at the NASA Goddard Space Flight Center (GSFC). The offices serve as the implementation arm for the Astrophysics Division at NASA Headquarters. We present an overview of the programs' technology development activities and technology investment portfolio, funded by NASA's Strategic Astrophysics Technology (SAT) program. We currently fund 19 technology advancements to enable future PCOS and COR missions to help answer the questions "How did our universe begin and evolve?" and "How did galaxies, stars, and planets come to be?" We discuss the process for addressing community-provided technology gaps and Technology Management Board (TMB)-vetted prioritization and investment recommendations that inform the SAT program. The process improves the transparency and relevance of our technology investments, provides the community a voice in the process, and promotes targeted external technology investments by defining needs and identifying customers. The programs' goal is to promote and support technology development needed to enable missions envisioned by the National Research Council's (NRC) "New Worlds, New Horizons in Astronomy and Astrophysics" (NWNH) Decadal Survey report [1] and the Astrophysics Implementation Plan (AIP) [2]. These include technology development for dark energy, gravitational waves, X-ray and inflation probe science, and a 4m-class UV/optical telescope to conduct imaging and spectroscopy studies, as a post-Hubble observatory with significantly improved sensitivity and capability.

NASA's Physics of the Cosmos and Cosmic Origins Technology Development Programs

NASA Technical Reports Server (NTRS)

Clampin, Mark; Pham, Thai

2014-01-01

NASA's Physics of the Cosmos (PCOS) and Cosmic Origins (COR) Program Offices, established in 2011, reside at the NASA Goddard Space Flight Center (GSFC). The offices serve as the implementation arm for the Astrophysics Division at NASA Headquarters. We present an overview of the programs' technology development activities and technology investment portfolio, funded by NASA's Strategic Astrophysics Technology (SAT) program. We currently fund 19 technology advancements to enable future PCOS and COR missions to help answer the questions "How did our universe begin and evolve?" and "How did galaxies, stars, and planets come to be?" We discuss the process for addressing community-provided technology gaps and Technology Management Board (TMB)-vetted prioritization and investment recommendations that inform the SAT program. The process improves the transparency and relevance of our technology investments, provides the community a voice in the process, and promotes targeted external technology investments by defining needs and identifying customers. The programs' goal is to promote and support technology development needed to enable missions envisioned by the National Research Council's (NRC) "New Worlds, New Horizons in Astronomy and Astrophysics" (NWNH) Decadal Survey report [1] and the Astrophysics Implementation Plan (AIP) [2]. These include technology development for dark energy, gravitational waves, X-ray and inflation probe science, and a 4m-class UV/optical telescope to conduct imaging and spectroscopy studies, as a post-Hubble observatory with significantly improved sensitivity and capability.

NASA's Physics of the Cosmos and Cosmic Origins Technology Development Programs

NASA Technical Reports Server (NTRS)

Pham, Thai; Seery, Bernard; Ganel, Opher

2016-01-01

The strategic astrophysics missions of the coming decades will help answer the questions "How did our universe begin and evolve?" and "How did galaxies, stars, and planets come to be?" Enabling these missions requires advances in key technologies far beyond the current state of the art. NASA's Physics of the Cosmos (PCOS) and Cosmic Origins (COR) Program Offices manage technology maturation projects funded through the Strategic Astrophysics Technology (SAT) program to accomplish such advances. The PCOS and COR Program Offices, residing at the NASA Goddard Space Flight Center (GSFC), were established in 2011, and serve as the implementation arm for the Astrophysics Division at NASA Headquarters. We present an overview of the Programs' technology development activities and the current technology investment portfolio of 23 technology advancements. We discuss the process for addressing community-provided technology gaps and Technology Management Board (TMB)-vetted prioritization and investment recommendations that inform the SAT program. The process improves the transparency and relevance of our technology investments, provides the community a voice in the process, and promotes targeted external technology investments by defining needs and identifying customers. The Programs' priorities are driven by strategic direction from the Astrophysics Division, which is informed by the National Research Council's (NRC) "New Worlds, New Horizons in Astronomy and Astrophysics" (NWNH) 2010 Decadal Survey report [1], the Astrophysics Implementation Plan (AIP) [2] as updated, and the Astrophysics Roadmap "Enduring Quests, Daring Visions" [3]. These priorities include technology development for missions to study dark energy, gravitational waves, X-ray and inflation probe science, and large far-infrared (IR) and ultraviolet (UV)/optical/IR telescopes to conduct imaging and spectroscopy studies. The SAT program is the Astrophysics Division's main investment method to mature technologies that will be identified by study teams set up to inform the 2020 Decadal Survey process on several large astrophysics mission concepts.

76 FR 22673 - Technology Innovation Program Advisory Board

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-22

... DEPARTMENT OF COMMERCE National Institute of Standards and Technology Technology Innovation Program Advisory Board AGENCY: National Institute of Standards and Technology, Department of Commerce... Standards and Technology (NIST) published a notice in the Federal Register announcing an open meeting for...

Fossil Energy Program Annual Progress Report for the Period April 1, 2000 through March 31, 2001

DOE Office of Scientific and Technical Information (OSTI.GOV)

Judkins, RR

This report covers progress made at Oak Ridge National Laboratory (ORNL) on research and development projects that contribute to the advancement of fossil energy technologies. Projects on the ORNL Fossil Energy Program are supported by the U.S. Department of Energy (DOE) Office of Fossil Energy, the DOE National Energy Technology Laboratory (NETL), the DOE Fossil Energy Clean Coal Technology (CCT) Program, the DOE National Petroleum Technology Office, and the DOE Fossil Energy Office of Strategic Petroleum Reserve (SPR). The ORNL Fossil Energy Program research and development activities cover the areas of coal, clean coal technology, gas, petroleum, and support tomore » the SPR. An important part of the Fossil Energy Program is technical management of all activities on the DOE Fossil Energy Advanced Research (AR) Materials Program. The AR Materials Program involves research at other DOE and government laboratories, at universities, and at industrial organizations.« less

Energy and technology review

NASA Astrophysics Data System (ADS)

Johnson, K. C.

1991-04-01

This issue of Energy and Technology Review discusses the various educational programs in which Lawrence Livermore National Laboratory (LLNL) participates or sponsors. LLNL has a long history of fostering educational programs for students from kindergarten through graduate school. A goal is to enhance the teaching of science, mathematics, and technology and thereby assist educational institutions to increase the pool of scientists, engineers, and technicians. LLNL programs described include: (1) contributions to the improvement of U.S. science education; (2) the LESSON program; (3) collaborations with Bay Area Science and Technology Education; (4) project HOPES; (5) lasers and fusion energy education; (6) a curriculum on global climate change; (7) computer and technology instruction at LLNL's Science Education Center; (8) the National Education Supercomputer Program; (9) project STAR; (10) the American Indian Program; (11) LLNL programs with historically Black colleges and Universities; (12) the Undergraduate Summer Institute on Contemporary Topics in Applied Science; (13) the National Physical Science Consortium: A Fellowship Program for Minorities and Women; (14) LLNL's participation with AWU; (15) the apprenticeship programs at LLNL; and (16) the future of LLNL's educational programs. An appendix lists all of LLNL's educational programs and activities. Contacts and their respective telephone numbers are given for all these programs and activities.

SUPERFUND INNOVATIVE TECHNOLOGY EVALUATION PROGRAM: INNOVATION MAKING A DIFFERENCE

EPA Science Inventory

The Superfund Innovative Technology Evaluation (SITE) Program encourages commercialization of innovative technologies for characterizing and remediating hazardous waste site contamination through four components: Demonstration, Emerging Technology, and Monitoring & Measurement Pr...

Technology transfer from the viewpoint of a NASA prime contractor

NASA Technical Reports Server (NTRS)

Dyer, Gordon

1992-01-01

Viewgraphs on technology transfer from the viewpoint of a NASA prime contractor are provided. Technology Transfer Program for Manned Space Systems and the Technology Transfer Program status are addressed.

Environmental Technology Verification (ETV) Quality Program (Poster)

EPA Science Inventory

This is a poster created for the ETV Quality Program. The EPA Environmental Technology Verification Program (ETV) develops test protocols and verifies the performance of innovative technologies that have the potential to improve protection of human health and the environment. The...

ENVIRONMENTAL TECHNOLOGY VERIFICATION AND INDOOR AIR

EPA Science Inventory

The paper discusses environmental technology verification and indoor air. RTI has responsibility for a pilot program for indoor air products as part of the U.S. EPA's Environmental Technology Verification (ETV) program. The program objective is to further the development of sel...

ENVIRONMENTAL TECHNOLOGY VERIFICATION (ETV) PROGRAM CASE STUDIES: DEMONSTRATING PROGRAM OUTCOMES, VOLUME II

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) Environmental Technology Verification (ETV) Program evaluates the performance of innovative air, water, pollution prevention and monitoring technologies that have the potential to improve human health and the environment. This bookle...

Environmental Technology Verification Program - ETV - Case Studies: Demonstrating Program Outcomes

EPA Science Inventory

The U.S. Environmental Protection Agency (EPA) Environmental Technology Verification (ETV) Program evaluates the performance of innovative air, water, pollution prevention and monitoring technologies that have the potential to improve human health and the environment. This cd con...

7 CFR 90.2 - General terms defined.

Code of Federal Regulations, 2013 CFR

2013-01-01

... the Science and Technology program of the Agricultural Marketing Service agency, or any officer or... be delegated, to act. Laboratories. Science and Technology laboratories performing the official analyses described in this subchapter. Program. The Science and Technology (S&T) program of the...

7 CFR 90.2 - General terms defined.

Code of Federal Regulations, 2012 CFR

2012-01-01

... the Science and Technology program of the Agricultural Marketing Service agency, or any officer or... be delegated, to act. Laboratories. Science and Technology laboratories performing the official analyses described in this subchapter. Program. The Science and Technology (S&T) program of the...

7 CFR 90.2 - General terms defined.

Code of Federal Regulations, 2014 CFR

2014-01-01

... the Science and Technology program of the Agricultural Marketing Service agency, or any officer or... be delegated, to act. Laboratories. Science and Technology laboratories performing the official analyses described in this subchapter. Program. The Science and Technology (S&T) program of the...

75 FR 70578 - Competitive and Noncompetitive Nonformula Federal Assistance Programs-Administrative Provisions...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-18

..., extension, and education programs on technology development and integrated research, extension, and education programs on technology implementation, in accordance with the purpose and priorities as described... the development, distribution, and implementation of biobased energy technologies; to promote...

SUPERFUND INNOVATIVE TECHNOLOGY EVALUATION PROGRAM ANNUAL REPORT TO CONGRESS FY 2002

EPA Science Inventory

This report details the Fiscal Year 2002 activities of the Superfund Innovative Technology Evaluation (SITE) Program. The Program focused on the remediation needs of the hazardous waste remediation community through demonstration and evaluation of innovative technologies for reme...

SUPERFUND INNOVATIVE TECHNOLOGY EVALUATION PROGRAM ANNUAL REPORT TO CONGRESS FY 2001

EPA Science Inventory

This report details the fiscal year 2001 activities of the Superfund Innovative Technology Evaluation (SITE) Program. The Program focuses on the remediation needs of the hazardous waste remediation community through demonstration and evaluation of innovative technologies for re...

SUPERFUND INNOVATIVE TECHNOLOGY EVALUATION PROGRAM ANNUAL REPORT TO CONGRESS FY 1995

EPA Science Inventory

The Superfund Innovative Technology Evaluation (SITE) Program was established more than nine years ago to encourage the development and implementation of innovative treatment technologies for hazardous waste site remediation. Development of this program was in direct response to ...

15 CFR 290.3 - Program description.

Code of Federal Regulations, 2012 CFR

2012-01-01

... OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE... subject of research in NIST's Automated Manufacturing Research Facility (AMRF). The core of AMRF research... manufacturing technology. (b) Program objective. The objective of the NIST Manufacturing Technology Centers is...

15 CFR 290.3 - Program description.

Code of Federal Regulations, 2014 CFR

2014-01-01

... OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE... subject of research in NIST's Automated Manufacturing Research Facility (AMRF). The core of AMRF research... manufacturing technology. (b) Program objective. The objective of the NIST Manufacturing Technology Centers is...

15 CFR 290.3 - Program description.

Code of Federal Regulations, 2013 CFR

2013-01-01

... OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE... subject of research in NIST's Automated Manufacturing Research Facility (AMRF). The core of AMRF research... manufacturing technology. (b) Program objective. The objective of the NIST Manufacturing Technology Centers is...

USEPA SITE PROGRAM APPROACH TO TECHNOLOGY TRANSFER AND REGULATORY ACCEPTANCE

EPA Science Inventory

The SITE Program was created to meet the increased demand for innovative technologies for hazardous waste treatment. To accomplish this mission, the program seeks to advance the development, implementation and commercialization of innovative technologies for hazardous waste chara...

78 FR 31535 - Assistive Technology Alternative Financing Program

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-24

... DEPARTMENT OF EDUCATION Assistive Technology Alternative Financing Program AGENCY: Office of Special Education and Rehabilitative Services, Department of Education. ACTION: Notice. Catalog of Federal... developed for the Assistive Technology (AT) Alternative Financing Program (AFP) in fiscal year (FY) 2012 to...

Technology Transition a Model for Infusion and Commercialization

NASA Technical Reports Server (NTRS)

McMillan, Vernotto C.

2006-01-01

The National Aeronautics and Space Administration has as part of its charter the mission of transferring technologies developed for the space program into the private sector for the purpose of affording back to the American people the economical and improved quality of life benefits associated with the technologies developed. In recent years considerable effort has been made to use this program for not only transitioning technologies out of the NASA Mission Directorate Programs, but also to transfer technologies into the Mission Directorate Programs and leverage the impact of government and private sector innovation. The objective of this paper is to outline an approach and the creation of a model that brings together industry, government, and commercialization strategies. When these elements are integrated, the probability of successful technology development, technology infusion into the Mission Programs, and commercialization into the private sector is increased. This model primarily addresses technology readiness levels between TRL 3 and TRL 6. This is typically a gap area known as the valley of death. This gap area is too low for commercial entities to invest heavily and not developed enough for major programs to actively pursue. This model has shown promise for increasing the probably of TRL advancement to an acceptable level for NASA programs and/or commercial entities to afford large investments toward either commercialization or infusion.

NASA space research and technology overview (ITP)

NASA Technical Reports Server (NTRS)

Reck, Gregory M.

1992-01-01

A series of viewgraphs summarizing NASA space research and technology is presented. Some of the specific topics covered include the organization and goals of the Office of Aeronautics and Space Technology, technology maturation strategy, integrated technology plan for the Civil Space Program, program selection and investment prioritization, and space technology benefits.

Programming and Technology for Accessibility in Geoscience

NASA Astrophysics Data System (ADS)

Sevre, E.; Lee, S.

2013-12-01

Many people, students and professors alike, shy away from learning to program because it is often believed to be something scary or unattainable. However, integration of programming into geoscience education can be a valuable tool for increasing the accessibility of content for all who are interested. It is my goal to dispel these myths and convince people that: 1) Students with disabilities can use programming to increase their role in the classroom, 2) Everyone can learn to write programs to simplify daily tasks, 3) With a deep understanding of the task, anyone can write a program to do a complex task, 4) Technology can be combined with programming to create an inclusive environment for all students of geoscience, and 5) More advanced knowledge of programming and technology can lead geoscientists to create software to serve as assistive technology in the classroom. It is my goal to share my experiences using technology to enhance the classroom experience as a way of addressing the aforementioned issues. Through my experience, I have found that programming skills can be included and learned by all to enhance the content of courses without detracting from curriculum. I hope that, through this knowledge, geoscience courses can become more accessible for people with disabilities by including programming and technology to the benefit of all involved.

Proposed Social Spending Innovation Research (SSIR) Program: Harnessing American Entrepreneurial Talent to Solve Major U.S. Social Problems

ERIC Educational Resources Information Center

Coalition for Evidence-Based Policy, 2015

2015-01-01

The Social Spending Innovation Research (SSIR) proposal seeks to replicate, in social spending, the great success of the Small Business Innovation Research (SBIR) program in technology development. The SBIR program funds technology development by entrepreneurial small companies. The program has spawned breakthrough technologies in diverse areas…

The Computer Experience Microvan Program: A Cooperative Endeavor to Improve University-Public School Relations through Technology.

ERIC Educational Resources Information Center

Amodeo, Luiza B.; Martin, Jeanette

To a large extent the Southwest can be described as a rural area. Under these circumstances, programs for public understanding of technology become, first of all, exercises in logistics. In 1982, New Mexico State University introduced a program to inform teachers about computer technology. This program takes microcomputers into rural classrooms…

23 CFR 420.207 - What are the requirements for research, development, and technology transfer work programs?

Code of Federal Regulations, 2013 CFR

2013-04-01

..., Development and Technology Transfer Program Management § 420.207 What are the requirements for research, development, and technology transfer work programs? (a) The State DOT's RD&T work program must, as a minimum... 23 Highways 1 2013-04-01 2013-04-01 false What are the requirements for research, development, and...

23 CFR 420.207 - What are the requirements for research, development, and technology transfer work programs?

Code of Federal Regulations, 2010 CFR

2010-04-01

..., Development and Technology Transfer Program Management § 420.207 What are the requirements for research, development, and technology transfer work programs? (a) The State DOT's RD&T work program must, as a minimum... 23 Highways 1 2010-04-01 2010-04-01 false What are the requirements for research, development, and...

23 CFR 420.207 - What are the requirements for research, development, and technology transfer work programs?

Code of Federal Regulations, 2014 CFR

2014-04-01

..., Development and Technology Transfer Program Management § 420.207 What are the requirements for research, development, and technology transfer work programs? (a) The State DOT's RD&T work program must, as a minimum... 23 Highways 1 2014-04-01 2014-04-01 false What are the requirements for research, development, and...

23 CFR 420.207 - What are the requirements for research, development, and technology transfer work programs?

Code of Federal Regulations, 2012 CFR

2012-04-01

..., Development and Technology Transfer Program Management § 420.207 What are the requirements for research, development, and technology transfer work programs? (a) The State DOT's RD&T work program must, as a minimum... 23 Highways 1 2012-04-01 2012-04-01 false What are the requirements for research, development, and...

23 CFR 420.207 - What are the requirements for research, development, and technology transfer work programs?

Code of Federal Regulations, 2011 CFR

2011-04-01

..., Development and Technology Transfer Program Management § 420.207 What are the requirements for research, development, and technology transfer work programs? (a) The State DOT's RD&T work program must, as a minimum... 23 Highways 1 2011-04-01 2011-04-01 false What are the requirements for research, development, and...

34 CFR 614.1 - What is the purpose of the Preparing Tomorrow's Teachers to Use Technology program?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false What is the purpose of the Preparing Tomorrow's Teachers to Use Technology program? 614.1 Section 614.1 Education Regulations of the Offices of the... Use Technology program? (a) This program provides grants to help future teachers become proficient in...

Mississippi Curriculum Framework for Forestry Technology (Program CIP: 03.0401--Forest Harvesting and Production Technology). Postsecondary Programs.

ERIC Educational Resources Information Center

Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the forestry technology program cluster. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies for the…

Mississippi Curriculum Framework for Medical Radiologic Technology (Radiography) (CIP: 51.0907--Medical Radiologic Technology). Postsecondary Programs.

ERIC Educational Resources Information Center

Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the radiologic technology program. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies for the program,…

Programs for Middle School Math: An Inventory of Existing Technology. Working Paper

ERIC Educational Resources Information Center

Saultz, Andrew

2012-01-01

In this working paper, Andrew Saultz of Michigan State University inventories the current landscape of technology programs available for middle school math. The working paper is not intended as a "consumers' guide" to technology programs, and the descriptions of some specific programs are not fully accurate or current. Readers who are interested…

Preparing for High Technology: Model Programs in the USA. Research and Development Series No. 258.

ERIC Educational Resources Information Center

Doty, Charles R.

This publication identifies exemplary programs and human resources in the automated manufacturing technologies. Its purpose is to assist vocational education program planners and curriculum specialists in updating programs and staff skills to prepare for high technology. Chapter 1 is an introduction. Chapter 2 describes the seven U.S. Secretary of…

Mississippi Curriculum Framework for Civil Technology (Program CIP: 15.0201--Civil Engineering/Civil Technology). Postsecondary Programs.

ERIC Educational Resources Information Center

Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the civil technology programs cluster. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies, and section…

Mississippi Curriculum Framework for Medical Laboratory Technology Programs (CIP: 51.1004--Medical Laboratory Technology). Postsecondary Programs.

ERIC Educational Resources Information Center

Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the course sequences in the medical laboratory technology program. Presented in the introductory section are a description of the program and suggested course sequence. Section I lists baseline competencies, and…

Future Orbital Power Systems Technology Requirements

NASA Technical Reports Server (NTRS)

1978-01-01

NASA is actively involved in program planning for missions requiring several orders of magnitude, more energy than in the past. Therefore, a two-day symposium was held to review the technology requirements for future orbital power systems. The purpose of the meeting was to give leaders from government and industry a broad view of current government supported technology efforts and future program plans in space power. It provided a forum for discussion, through workshops, to comment on current and planned programs and to identify opportunities for technology investment. Several papers are presented to review the technology status and the planned programs.

NDE Technology Development Program for Non-Visual Volumetric Inspection Technology; Sensor Effectiveness Testing Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moran, Traci L.; Larche, Michael R.; Denslow, Kayte M.

The Pacific Northwest National Laboratory (PNNL) located in Richland, Washington, hosted and administered Sensor Effectiveness Testing that allowed four different participants to demonstrate the NDE volumetric inspection technologies that were previously demonstrated during the Technology Screening session. This document provides a Sensor Effectiveness Testing report for the final part of Phase I of a three-phase NDE Technology Development Program designed to identify and mature a system or set of non-visual volumetric NDE technologies for Hanford DST primary liner bottom inspection. Phase I of the program will baseline the performance of current or emerging non-visual volumetric NDE technologies for their abilitymore » to detect and characterize primary liner bottom flaws, and identify candidate technologies for adaptation and maturation for Phase II of the program.« less

Spinoff 1978

NASA Technical Reports Server (NTRS)

Haggerty, James J.

1978-01-01

Spinoff '78 is the annual report of NASA's Technology Utilization Program, which is charged with promoting and stimulating the practical application of government-sponsored aerospace technology. The report is organized in three sections: 1) Aerospace Aims; 2) Technology Twice Used; and 3) Technology Utilization. Section 1 outlines NASA's major programs in space exploration, aeronautical research and technology application, and describes the potential benefits of a direct nature that are accruing from these efforts. Section 2 contains a representative sampling of the indirect benefits resulting from the secondary use of aerospace technology in industry and the economy. Section 3 details the nationwide activities of the Technology Utilization Program in encouraging the broadest possible secondary use of new technology emerging from aerospace programs. The latter section also includes a list of regional NASA officials and others who can be contacted by those seeking NASA technical information or assistance.

Spinoff 2002: Fortieth Anniversary Technology Utilization Program

NASA Technical Reports Server (NTRS)

2002-01-01

Since its inception 40 years ago, NASA's Technology Transfer Program has led the way for our nation to benefit from cutting-edge aerospace technologies. In addition to contributing to U.S. economic growth, these technologies are improving the quality of life on Earth while finding new ways to protect and preserve it. NASA's research and development efforts have advanced areas in medicine, communications, manufacturing, computer technology, and homeland security. These breakthroughs, translated into commercial products, are enhancing the lives of Americans everywhere. When a congressional mandate led NASA to develop the Scientific and Technical Information (STI) Program, the Agency began a wide dissemination of its research and development results. In doing so, NASA recognized that many of its technologies were transferable to industry for the development of commercial products. As a result, the Technology Utilization Program was born in 1962. The successful program went through several changes over the years, as its philosophy, mission, and goals adapted into the Technology Transfer Program we know today. The program strives to make the latest technologies available to industry as soon as they are developed. Each year, NASA's Spinoff publication showcases new products and services resulting from commercial partnerships between NASA and private industry. In the 2002 issue, the NASA field centers reflect upon the growth that has made these innovations available to the public. The Research and Development section examines past achievements, current successes, and future goals for each of the ten NASA centers. The Commercial Benefits section proudly highlights 51 new spinoff products, including a heart pump for patients needing a heart transplant, as well as an air purifier that destroys anthrax spores. The Technology Transfer and Outreach section describes the outreach achievements and educational successes made possible through the NASA Commercial Technology Network. Each section of Spinoff 2002 provides compelling evidence of the Technology Transfer Program's success and value. With commercial products and successes spanning from work on the Apollo missions to the International Space Station, the 40th anniversary of the Technology Transfer Program invites us to celebrate our history while planning the future.

Technology Evaluation Report - SITE PROGRAM DEMONSTRATION OF THE ULTROX INTERNATIONAL ULTRAVIOLET RADIATION OXIDATION TECHNOLOGY

EPA Science Inventory

In support of EPA's Superfund Innovative Technology Evaluation (SITE) Program, this report presents the results of the Ultrox International technology demonstration. The Ultrox® technology (a registered trademark of Ultrox International) simultaneously uses ultraviolet (UV) radi...

U.S. ENVIRONMENTAL PROTECTION AGENCY (EPA) ENVIRONMENTAL TECHNOLOGY VERIFICATION (ETV) PROGRAM: ARSENIC MONITORING TECHNOLOGIES

EPA Science Inventory

The U.S. Environmental Protection Agency Environmental Technology Verification (ETV) program evaluates the performance of innovative air, water, pollution prevention and monitoring technologies that have the potential to improve human health and the environment. This technology ...

Computer Engineering Technology. Florida Vocational Program Guide.

ERIC Educational Resources Information Center

University of South Florida, Tampa. Dept. of Adult and Vocational Education.

This packet contains a program guide and Career Merit Achievement Plan (Career MAP) for the implementation of a computer engineering technology program in Florida secondary and postsecondary schools. The program guide describes the program content and structure, provides a program description, lists job titles under the program, and includes a…

Recommendations for the Improved Effectiveness and Reporting of Telemedicine Programs in Developing Countries: Results of a Systematic Literature Review.

PubMed

Khanal, Sumesh; Burgon, Joseph; Leonard, Saoirse; Griffiths, Matthew; Eddowes, Lucy A

2015-11-01

A lack of decisive evidence on the impact of telemedicine on financial and clinical outcomes has not prohibited significant investment in developing countries. Understanding characteristics that facilitate effective telemedicine programs is required to allow telemedicine to be used to its full potential. This systematic review aimed to identify organizational, technological, and financial features of successful telemedicine programs providing direct clinical care in developing countries. Databases were searched, and the results were reviewed systematically according to predefined inclusion/exclusion criteria. Information on location(s), measure of success, and organizational, technological, and financial characteristics were extracted. This review was impeded by inadequate program reporting, and so a concise checklist was developed to aid improved reporting, enabling future reviews to identify key characteristics of effective programs. This systematic review identified 46 articles reporting 36 programs that fulfilled the inclusion/exclusion criteria. Programs were distributed globally, including regional, national, and international programs. Technological modalities included synchronous technology, real-time teleconsultations, and asynchronous technology. Program integration with existing systems and twinning of international institutions were identified as factors enabling program success. Other factors included simple and easy-to-use technology, ability to reduce the burden on healthcare professionals, and technology able to maintain functionality in challenging environmental circumstances. Reports describing effectiveness and costs were limited. This systematic review identified key factors associated with telemedicine program success. However, inconsistencies in reporting represent an obstacle to establishment of successful programs in developing countries by limiting the application of previous experiences. Adhering to the guidelines suggested here may allow more quantitative assessments of effectiveness and impact for future programs.

Non-Constant Learning Rates in Retrospective Experience Curve Analyses and their Correlation to Deployment Programs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wei, Max; Smith, Sarah J.; Sohn, Michael D.

2015-07-16

A key challenge for policy-makers and technology market forecasters is to estimate future technology costs and in particular the rate of cost reduction versus production volume. A related, critical question is what role should state and federal governments have in advancing energy efficient and renewable energy technologies? This work provides retrospective experience curves and learning rates for several energy-related technologies, each of which have a known history of federal and state deployment programs. We derive learning rates for eight technologies including energy efficient lighting technologies, stationary fuel cell systems, and residential solar photovoltaics, and provide an overview and timeline ofmore » historical deployment programs such as state and federal standards and state and national incentive programs for each technology. Piecewise linear regimes are observed in a range of technology experience curves, and public investments or deployment programs are found to be strongly correlated to an increase in learning rate across multiple technologies. A downward bend in the experience curve is found in 5 out of the 8 energy-related technologies presented here (electronic ballasts, magnetic ballasts, compact fluorescent lighting, general service fluorescent lighting, and the installed cost of solar PV). In each of the five downward-bending experience curves, we believe that an increase in the learning rate can be linked to deployment programs to some degree. This work sheds light on the endogenous versus exogenous contributions to technological innovation and highlights the impact of exogenous government sponsored deployment programs. This work can inform future policy investment direction and can shed light on market transformation and technology learning behavior.« less

Housing Star Schools Reforms.

ERIC Educational Resources Information Center

Tushnet, Naida C.

The Star Schools Program has funded projects to explore innovative educational applications of technology in distance education. Funded projects have applied a variety of technologies, including videodisks, compressed data transmission, fiber optic technology, and computer networks. Program evaluation is a mandated aspect of the program. This…

32 CFR 2400.46 - Suggestions or complaints.

Code of Federal Regulations, 2014 CFR

2014-07-01

... POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.46... Science and Technology Policy Information Security Program should do so in writing. This correspondence...

32 CFR 2400.46 - Suggestions or complaints.

Code of Federal Regulations, 2012 CFR

2012-07-01

... POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.46... Science and Technology Policy Information Security Program should do so in writing. This correspondence...

32 CFR 2400.46 - Suggestions or complaints.

Code of Federal Regulations, 2010 CFR

2010-07-01

... POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.46... Science and Technology Policy Information Security Program should do so in writing. This correspondence...

32 CFR 2400.46 - Suggestions or complaints.

Code of Federal Regulations, 2011 CFR

2011-07-01

... POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.46... Science and Technology Policy Information Security Program should do so in writing. This correspondence...

32 CFR 2400.46 - Suggestions or complaints.

Code of Federal Regulations, 2013 CFR

2013-07-01

... POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY PROGRAM Office of Science and Technology Policy Information Security Program Management § 2400.46... Science and Technology Policy Information Security Program should do so in writing. This correspondence...

15 CFR 290.3 - Program description.

Code of Federal Regulations, 2011 CFR

2011-01-01

... OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE TRANSFER OF MANUFACTURING TECHNOLOGY § 290.3 Program description. (a) The Secretary, acting through the... for the Transfer of Manufacturing Technology. Each Center shall be affiliated with a U.S.-based...

15 CFR 290.3 - Program description.

Code of Federal Regulations, 2010 CFR

2010-01-01

... OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NIST EXTRAMURAL PROGRAMS REGIONAL CENTERS FOR THE TRANSFER OF MANUFACTURING TECHNOLOGY § 290.3 Program description. (a) The Secretary, acting through the... for the Transfer of Manufacturing Technology. Each Center shall be affiliated with a U.S.-based...

The Berry Informational Technology (B.I.T.S.) Student Work Program: An Effective Environment for Collaborative Learning, Leadership, Technological Training, and Certification.

ERIC Educational Resources Information Center

Cornelius, Amy; Macaluso, Paul

The Berry Informational Technology (B.I.T.S.) program at Berry College (Georgia) is an apprenticeship opportunity associated with student work. The program gives students the opportunity to seek technological training in areas, such as building computer systems, trouble-shooting, networking, Web development, and user and technical support. In…

NASA technology utilization program: The small business market

NASA Technical Reports Server (NTRS)

Vannoy, J. K.; Garcia-Otero, F.; Johnson, F. D.; Staskin, E.

1980-01-01

Technology transfer programs were studied to determine how they might be more useful to the small business community. The status, needs, and technology use patterns of small firms are reported. Small business problems and failures are considered. Innovation, capitalization, R and D, and market share problems are discussed. Pocket, captive, and new markets are summarized. Small manufacturers and technology acquisition are discussed, covering external and internal sources, and NASA technology. Small business and the technology utilization program are discussed, covering publications and industrial applications centers. Observations and recommendations include small business market development and contracting, and NASA management technology.

Civil space technology initiative

NASA Technical Reports Server (NTRS)

1990-01-01

The Civil Space Technology Initiative (CSTI) is a major, focused, space technology program of the Office of Aeronautics, Exploration and Technology (OAET) of NASA. The program was initiated to advance technology beyond basic research in order to expand and enhance system and vehicle capabilities for near-term missions. CSTI takes critical technologies to the point at which a user can confidently incorporate the new or expanded capabilities into relatively near-term, high-priority NASA missions. In particular, the CSTI program emphasizes technologies necessary for reliable and efficient access to and operation in Earth orbit as well as for support of scientific missions from Earth orbit.

Research and Energy Efficiency: Selected Success Stories

DOE R&D Accomplishments Database

Garland, P. W.; Garland, R. W.

1997-06-26

Energy use and energy technology play critical roles in the U.S. economy and modern society. The Department of Energy (DOE) conducts civilian energy research and development (R&D) programs for the purpose of identifying promising technologies that promote energy security, energy efficiency, and renewable energy use. DOE-sponsored research ranges from basic investigation of phenomena all the way through development of applied technology in partnership with industry. DOE`s research programs are conducted in support of national strategic energy objectives, however austere financial times have dictated that R&D programs be measured in terms of cost vs. benefit. In some cases it is difficult to measure the return on investment for the basic "curiosity-driven" research, however many applied technology development programs have resulted in measurable commercial successes. The DOE has published summaries of their most successful applied technology energy R&D programs. In this paper, we will discuss five examples from the Building Technologies area of the DOE Energy Efficiency program. Each story will describe the technology, discuss the level of federal funding, and discuss the returns in terms of energy savings, cost savings, or national economic impacts.

High-Performance, Space-Storable, Bi-Propellant Program Status

NASA Technical Reports Server (NTRS)

Schneider, Steven J.

2002-01-01

Bipropellant propulsion systems currently represent the largest bus subsystem for many missions. These missions range from low Earth orbit satellite to geosynchronous communications and planetary exploration. The payoff of high performance bipropellant systems is illustrated by the fact that Aerojet Redmond has qualified a commercial NTO/MMH engine based on the high Isp technology recently delivered by this program. They are now qualifying a NTO/hydrazine version of this engine. The advanced rhenium thrust chambers recently provided by this program have raised the performance of earth storable propellants from 315 sec to 328 sec of specific impulse. The recently introduced rhenium technology is the first new technology introduced to satellite propulsion in 30 years. Typically, the lead time required to develop and qualify new chemical thruster technology is not compatible with program development schedules. These technology development programs must be supported by a long term, Base R&T Program, if the technology s to be matured. This technology program then addresses the need for high performance, storable, on-board chemical propulsion for planetary rendezvous and descent/ascent. The primary NASA customer for this technology is Space Science, which identifies this need for such programs as Mars Surface Return, Titan Explorer, Neptune Orbiter, and Europa Lander. High performance (390 sec) chemical propulsion is estimated to add 105% payload to the Mars Sample Return mission or alternatively reduce the launch mass by 33%. In many cases, the use of existing (flight heritage) propellant technology is accommodated by reducing mission objectives and/or increasing enroute travel times sacrificing the science value per unit cost of the program. Therefore, a high performance storable thruster utilizing fluorinated oxidizers with hydrazine is being developed.

NASA programs in technology transfer and their relation to remote sensing education

NASA Technical Reports Server (NTRS)

Weinstein, R. H.

1980-01-01

Technology transfer to users is a central feature of NASA programs. In each major area of responsibility, a variety of mechanisms was established to provide for this transfer of operational capability to the proper end user, be it a Federal agency, industry, or other public sector users. In addition, the Technology Utilization program was established to cut across all program areas and to make available a wealth of 'spinoff' technology (i.e., secondary applications of space technology to ground-based use). The transfer of remote sensing technology, particularly to state and local users, presents some real challenges in application and education for NASA and the university community. The agency's approach to the transfer of remote sensing technology and the current and potential role of universities in the process are considered.

Computing, Information and Communications Technology (CICT) Website

NASA Technical Reports Server (NTRS)

Hardman, John; Tu, Eugene (Technical Monitor)

2002-01-01

The Computing, Information and Communications Technology Program (CICT) was established in 2001 to ensure NASA's Continuing leadership in emerging technologies. It is a coordinated, Agency-wide effort to develop and deploy key enabling technologies for a broad range of mission-critical tasks. The NASA CICT program is designed to address Agency-specific computing, information, and communications technology requirements beyond the projected capabilities of commercially available solutions. The areas of technical focus have been chosen for their impact on NASA's missions, their national importance, and the technical challenge they provide to the Program. In order to meet its objectives, the CICT Program is organized into the following four technology focused projects: 1) Computing, Networking and Information Systems (CNIS); 2) Intelligent Systems (IS); 3) Space Communications (SC); 4) Information Technology Strategic Research (ITSR).

NASA's Next Generation Launch Technology Program - Strategy and Plans

NASA Technical Reports Server (NTRS)

Hueter, Uwe

2003-01-01

The National Aeronautics and Space Administration established a new program office, Next Generation Launch Technology (NGLT) Program Office, last year to pursue technologies for future space launch systems. NGLT will fund research in key technology areas such as propulsion, launch vehicles, operations and system analyses. NGLT is part of NASA s Integrated Space Technology Plan. The NGLT Program is sponsored by NASA s Office of Aerospace Technology and is part of the Space Launch Initiative theme that includes both NGLT and Orbital Space Plane. NGLT will focus on technology development to increase safety and reliability and reduce overall costs associated with building, flying and maintaining the nation s next-generations of space launch vehicles. These investments will be guided by systems engineering and analysis with a focus on the needs of National customers.

Technology transfer

NASA Technical Reports Server (NTRS)

Penaranda, Frank E.

1992-01-01

The topics are presented in viewgraph form and include the following: international comparison of R&D expenditures in 1989; NASA Technology Transfer Program; NASA Technology Utilization Program thrusts for FY 1992 and FY 1993; National Technology Transfer Network; and NTTC roles.

The Superfund Innovative Technology Evaluation Program SUMMARY AND CLOSURE REPORT

EPA Science Inventory

The Superfund Innovative Technology Evaluation (SITE) Program promoted the development, commercialization, and implementation of innovative hazardous waste treatment technologies for 20 years. SITE offered a mechanism for conducting joint technology demonstration and evaluation ...

Health information technology: standards, implementation specifications, and certification criteria for electronic health record technology, 2014 edition; revisions to the permanent certification program for health information technology. Final rule.

PubMed

2012-09-04

With this final rule, the Secretary of Health and Human Services adopts certification criteria that establish the technical capabilities and specify the related standards and implementation specifications that Certified Electronic Health Record (EHR) Technology will need to include to, at a minimum, support the achievement of meaningful use by eligible professionals, eligible hospitals, and critical access hospitals under the Medicare and Medicaid EHR Incentive Programs beginning with the EHR reporting periods in fiscal year and calendar year 2014. This final rule also makes changes to the permanent certification program for health information technology, including changing the program's name to the ONC HIT Certification Program.

Two-Year ET Programs: Essential Topics and Levels of Proficiency.

ERIC Educational Resources Information Center

Gourley, Frank A., Jr.

1990-01-01

Reports the results of a survey of graduates, employers, and instructors of engineering technology programs for the essential topics in mechanical engineering technology, mechanical drafting/design technology, manufacturing engineering technology, and industrial engineering technology. Identifies the proficiency level suggested for classwork and…

Ultra-Efficient Engine Technology (UEET) Program

NASA Technical Reports Server (NTRS)

Manthey, Lori A.

2001-01-01

The Ultra-Efficient Engine Technology (UEET) Program includes seven key projects that work with industry to develop and hand off revolutionary propulsion technologies that will enable future-generation vehicles over a wide range of flight speeds. A new program office, the Ultra-Efficient Engine Technology (UEET) Program Office, was formed at the NASA Glenn Research Center to manage an important National propulsion program for NASA. The Glenn-managed UEET Program, which began on October 1, 1999, includes participation from three other NASA centers (Ames, Goddard, and Langley), as well as five engine companies (GE Aircraft Engines, Pratt & Whitney, Honeywell, Allison/Rolls Royce, and Williams International) and two airplane manufacturers (the Boeing Company and Lockheed Martin Corporation). This 6-year, nearly $300 million program will address local air-quality concerns by developing technologies to significantly reduce nitrogen oxide (NOx) emissions. In addition, it will provide critical propulsion technologies to dramatically increase performance as measured in fuel burn reduction that will enable reductions of carbon dioxide (CO2) emissions. This is necessary to address the potential climate impact of long-term aviation growth.

Research and Technology

NASA Technical Reports Server (NTRS)

1997-01-01

As the NASA Center responsible for preparing and launching space missions, the John F. Kennedy Space Center (KSC) is placing increasing emphasis on its advanced technology development program. This program encompasses the efforts of the entire KSC team, consisting of Government and contractor personnel, working in partnership with academic institutions and commercial industry. This edition of the KSC Research and Technology 1997 Annual Report covers the efforts of these contributors to the KSC advanced technology development program, as well as our technology transfer activities.

Mars base technology program overview

NASA Technical Reports Server (NTRS)

Chu, Chneg-Chih; Hayati, Samad A.; Udomkesmalee, Suraphol

2005-01-01

In this paper, we present an overview of the current technology portfolio for Mars Base Technology Program. Brief descriptions of the awarded technologies and the high-priority areas in both NRAs are provided to show the current focus of MTP. We also present the approach that MTP uses to evaluate technology maturity for each of the technology tasks.

Funding and Strategic Alignment Guidance for Infusing Small Business Innovation Research Technology Into Human Exploration and Operations Mission Directorate Projects at Glenn Research Center for 2015

NASA Technical Reports Server (NTRS)

Nguyen, Hung D.; Steele, Gynelle C.

2016-01-01

This report is intended to help NASA program and project managers incorporate Glenn Research Center Small Business Innovation Research/Small Business Technology Transfer (SBIR)/(STTR) technologies into NASA Human Exploration and Operations Mission Directorate (HEOMD) programs and projects. Other Government and commercial project managers can also find this useful. Introduction Incorporating Small Business Innovation Research (SBIR)-developed technology into NASA projects is important, especially given the Agency's limited resources for technology development. The SBIR program's original intention was for technologies that had completed Phase II to be ready for integration into NASA programs, however, in many cases there is a gap between Technology Readiness Levels (TRLs) 5 and 6 that needs to be closed. After SBIR Phase II projects are completed, the technology is evaluated against various parameters and a TRL rating is assigned. Most programs tend to adopt more mature technologies-at least TRL 6 to reduce the risk to the mission rather than adopt TRLs between 3 and 5 because those technologies are perceived as too risky. The gap between TRLs 5 and 6 is often called the "Valley of Death" (Figure 1), and historically it has been difficult to close because of a lack of funding support from programs. Several papers have already suggested remedies on how to close the gap (Refs. 1 to 4).

Expendable launch vehicles technology: A report to the US Senate and the US House of Representatives

NASA Technical Reports Server (NTRS)

1990-01-01

As directed in Public Law 100-657, Commercial Space Launch Act Amendments of 1988, and consistent with National Space Policy, NASA has prepared a report on a potential program of research on technologies to reduce the initial and recurring costs, increase reliability, and improve performance of expendable launch vehicles for the launch of commercial and government spacecraft into orbit. The report was developed in consultation with industry and in recognition of relevant ongoing and planned NASA and DoD technology programs which will provide much of the required launch systems technology for U.S. Government needs. Additional efforts which could be undertaken to strengthen the technology base are identified. To this end, focus is on needs for launch vehicle technology development and, in selected areas, includes verification to permit private-sector new technology application at reduced risk. If such a program were to be implemented, it would entail both government and private-sector effort and resources. The additional efforts identified would augment the existing launch vehicle technology programs. The additional efforts identified have not been funded, based upon agency assessments of relative priority vis-a-vis the existing programs. Throughout the consultation and review process, the industry representatives stressed the overriding importance of continuing the DoD/NASA Advanced Launch Development activity and other government technology programs as a primary source of essential launch vehicle technology.