Establishment and Implementation of a Required Medication Therapy Management Advanced Pharmacy Practice Experience

PubMed Central

Gilliam, Eric; Thompson, Megan; Vande Griend, Joseph

2017-01-01

Objective. To develop a community pharmacy-based medication therapy management (MTM) advanced pharmacy practice experience (APPE) that provides students with skills and knowledge to deliver entry-level pharmacy MTM services. Design. The University of Colorado Skaggs School of Pharmacy & Pharmaceutical Sciences (SSPPS) partnered with three community pharmacy chains to establish this three-week, required MTM APPE. Students completed the American Pharmacists Association MTM Certificate Course prior to entering the APPE. Students were expected to spend 90% or more of their time at this experience working on MTM interventions, using store MTM platforms. Assessment. All 151 students successfully completed this MTM APPE, and each received a passing evaluation from their preceptor. Preceptor evaluations of students averaged above four (entry-level practice) on a five-point Likert scale. The majority of students reported engagement in MTM services for more than 80% of the time on site. Students’ self-reporting of their ability to perform MTM interventions improved after participation in the APPE. Conclusion. The SSPPS successfully implemented a required MTM APPE, preparing students for entry-level delivery of MTM services. PMID:28381896

Impact of live medication therapy management on cholesterol values in patients with cardiovascular disease.

PubMed

Thumar, Ricky; Zaiken, Kathy

2014-01-01

To compare the impact of clinical pharmacist (CP) recommendations through a live, primary care-based, medication therapy management (MTM) protocol on low-density-lipoprotein (LDL) cholesterol in patients who have cardiovascular disease (CVD) with standard, chart-review MTM. Patients with established CVD who were not at their LDL goal were identified and analyzed by either a chart-review MTM service or a live, one-on-one pharmacist-physician MTM service over a 6-month timeframe. For the chart-review MTM service, recommendations were communicated through an electronic medical record (EMR) that the physician and pharmacist had access to. Primary outcomes included mean LDL reduction from baseline, number of patients achieving their LDL goal, and percent of implemented CP recommendations. Mean LDL reduction from baseline in the chart-review MTM group and the live MTM group was 36 mg/dL ± 23.2 mg/dL (P = 0.001) and 62 mg/dL ± 28.3 mg/dL (P = 0.001), respectively. The difference between these two groups was statistically significant (P = 0.001). The chart-review MTM group had 30% of patients reach their LDL goal with 66.3% of CP recommendations implemented compared to 51.3% and 86.3% for the same parameters in the live MTM group (P = 0.006 and P = 0.003, respectively). Although both MTM services provide a significant LDL reduction from baseline in patients with CVD, live MTM provides significantly greater LDL reductions, implemented CP recommendations, and goal attainment than chart-review MTM. Thus, live MTM services are more effective than chart-review MTM services, at least within the clinics that these protocols were assessed for the purposes of this study.

Freeze-drying in novel container system: Characterization of heat and mass transfer in glass syringes.

PubMed

Patel, Sajal M; Pikal, Michael J

2010-07-01

This study is aimed at characterizing and understanding different modes of heat and mass transfer in glass syringes to develop a robust freeze-drying process. Two different holder systems were used to freeze-dry in syringes: an aluminum (Al) block and a plexiglass holder. The syringe heat transfer coefficient was characterized by a sublimation test using pure water. Mannitol and sucrose (5% w/v) were also freeze-dried, as model systems, in both the assemblies. Dry layer resistance was determined from manometric temperature measurement (MTM) and product temperature was measured using thermocouples, and was also determined from MTM. Further, freeze-drying process was also designed using Smart freeze-dryer to assess its application for freeze-drying in novel container systems. Heat and mass transfer in syringes were compared against the traditional container system (i.e., glass tubing vial). In the Al block, the heat transfer was via three modes: contact conduction, gas conduction, and radiation with gas conduction being the dominant mode of heat transfer. In the plexiglass holder, the heat transfer was mostly via radiation; convection was not involved. Also, MTM/Smart freeze-drying did work reasonably well for freeze-drying in syringes. When compared to tubing vials, product temperature decreases and hence drying time increases in syringes. (c) 2010 Wiley-Liss, Inc. and the American Pharmacists Association

Potential Health Implications of the MTM Eligibility Criteria in the Affordable Care Act Across Racial and Ethnic Groups

PubMed Central

Wang, Junling; Qiao, Yanru; Tina Shih, Ya-Chen; Jamison, JoEllen Jarrett; Spivey, Christina A.; Wan, Jim Y.; White-Means, Shelley I.; Dagogo-Jack, Samuel; Cushman, William C.; Chisholm-Burns, Marie

2015-01-01

Background The Medicare Prescription Drug, Improvement, and Modernization Act (MMA) requires Part D plans to establish programs to provide medication therapy management (MTM) services starting from 2006. MTM services have been found to improve patient outcomes from pharmacotherapy, reduce emergency room visits and hospitalizations, and reduce health care costs in a cost-effective fashion. However, previous research found that Non-Hispanic Blacks (Blacks) and Hispanics may be less likely to be eligible for MTM services than Non-Hispanic Whites (Whites) among the Medicare population according to current Medicare MTM eligibility criteria. This is because the Medicare MTM eligibility criteria are predominantly based on medication utilization and costs, while Blacks and Hispanics tend to use fewer prescription medications and incur lower prescription medication costs. The Patient Protection and Affordable Care Act (PPACA) laid out a set of MTM eligibility criteria for eligible entities to target patients for MTM services: “(1) take 4 or more prescribed medications …; (2) take any ‘high risk’ medications; (3) have 2 or more chronic diseases… or (4) have undergone a transition of care, or other factors… that are likely to create a high risk of medication-related problems.” Objectives This study aimed to examine (1) racial/ethnic disparities in meeting the eligibility criteria for MTM services in PPACA among the Medicare population; and (2) whether there would be greater disparities in health and economic outcomes among MTM-ineligible than MTM-eligible groups. (If so, the PPACA MTM eligibility criteria may aggravate existing disparities.) Methods This was a retrospective cross-sectional analysis of Medicare Current Beneficiaries Survey (MCBS; 2007–2008). To determine medication characteristics, the Food and Drug Administration’s Electronic Orange Book was also used. Proportions of population eligible for MTM services based on the PPACA MTM eligibility criteria were compared across racial and ethnic groups using a chi-square test; a logistic regression model was used to adjust for population socio-demographic and health characteristics. Health and economic outcomes examined included health status (self-perceived good health status, number of chronic diseases, activities of daily living or ADLs, and instrumental activities of daily living or IADLs), health services utilization and costs (physician visits, emergency room visits, and total health care costs), and medication utilization patterns (generic dispensing ratio). To determine difference in disparities across MTM eligibility categories, difference-in-differences regressions of various functional forms were employed depending on the nature of the dependent variables. Interaction terms between the dummy variables for minority groups (e.g., Blacks or Hispanics) and MTM eligibility were included to test whether disparity patterns varied between MTM-ineligible and MTM-eligible individuals. Results The sample consisted of 12,966 Medicare beneficiaries, of which 11,161 were White, 930 were Black and 875 were Hispanic. Of the study sample, 9,992 Whites (86.4%), 825 Blacks (86.3%) and 733 Hispanics (80.6%) were eligible for MTM. The difference between Whites and Hispanics was significant (P<0.05) and the difference between Whites and Blacks were not significant (P>0.05). In multivariate analyses, significant disparity in eligibility for MTM services was found only between Hispanics and Whites (OR = 0.59; 95% CI = 0.43–0.82) but not between Blacks and Whites (OR=0.78; 95% CI=0.55–1.09). Disparities were greater among the MTM-ineligible than the MTM-eligible populations in self-perceived health status, ADLs, and IADLs for both Blacks and Hispanics compared with Whites. When analyzing number of chronic conditions, number and costs of physician visits and total healthcare costs, this study found lower racial and ethnic disparities among the non-eligible population than the eligible population. Conclusion Hispanics would be significantly less likely than Whites to qualify for MTM eligibility among the Medicare population according to the MTM eligibility criteria stipulated in PPACA. The PPACA MTM eligibility criteria may aggravate existing racial and ethnic disparities in health status but may remediate racial and ethnic disparities in health services utilization. Alternative MTM eligibility criteria other than PPACA MTM eligibility criteria may be needed to improve the efficiency and equity of access to Medicare Part D MTM programs. PMID:26521111

Modeling the human MTM1 p.R69C mutation in murine Mtm1 results in exon 4 skipping and a less severe myotubular myopathy phenotype

PubMed Central

Pierson, Christopher R.; Dulin-Smith, Ashley N.; Durban, Ashley N.; Marshall, Morgan L.; Marshall, Jordan T.; Snyder, Andrew D.; Naiyer, Nada; Gladman, Jordan T.; Chandler, Dawn S.; Lawlor, Michael W.; Buj-Bello, Anna; Dowling, James J.; Beggs, Alan H.

2012-01-01

X-linked myotubular myopathy (MTM) is a severe neuromuscular disease of infancy caused by mutations of MTM1, which encodes the phosphoinositide lipid phosphatase, myotubularin. The Mtm1 knockout (KO) mouse has a severe phenotype and its short lifespan (8 weeks) makes it a challenge to use as a model in the testing of certain preclinical therapeutics. Many MTM patients succumb early in life, but some have a more favorable prognosis. We used human genotype–phenotype correlation data to develop a myotubularin-deficient mouse model with a less severe phenotype than is seen in Mtm1 KO mice. We modeled the human c.205C>T point mutation in Mtm1 exon 4, which is predicted to introduce the p.R69C missense change in myotubularin. Hemizygous male Mtm1 p.R69C mice develop early muscle atrophy prior to the onset of weakness at 2 months. The median survival period is 66 weeks. Histopathology shows small myofibers with centrally placed nuclei. Myotubularin protein is undetectably low because the introduced c.205C>T base change induced exon 4 skipping in most mRNAs, leading to premature termination of myotubularin translation. Some full-length Mtm1 mRNA bearing the mutation is present, which provides enough myotubularin activity to account for the relatively mild phenotype, as Mtm1 KO and Mtm1 p.R69C mice have similar muscle phosphatidylinositol 3-phosphate levels. These data explain the basis for phenotypic variability among human patients with MTM1 p.R69C mutations and establish the Mtm1 p.R69C mouse as a valuable model for the disease, as its less severe phenotype will expand the scope of testable preclinical therapies. PMID:22068590

Association of Climatic Variability, Vector Population and Malarial Disease in District of Visakhapatnam, India: A Modeling and Prediction Analysis.

PubMed

Srimath-Tirumula-Peddinti, Ravi Chandra Pavan Kumar; Neelapu, Nageswara Rao Reddy; Sidagam, Naresh

2015-01-01

Malarial incidence, severity, dynamics and distribution of malaria are strongly determined by climatic factors, i.e., temperature, precipitation, and relative humidity. The objectives of the current study were to analyse and model the relationships among climate, vector and malaria disease in district of Visakhapatnam, India to understand malaria transmission mechanism (MTM). Epidemiological, vector and climate data were analysed for the years 2005 to 2011 in Visakhapatnam to understand the magnitude, trends and seasonal patterns of the malarial disease. Statistical software MINITAB ver. 14 was used for performing correlation, linear and multiple regression analysis. Perennial malaria disease incidence and mosquito population was observed in the district of Visakhapatnam with peaks in seasons. All the climatic variables have a significant influence on disease incidence as well as on mosquito populations. Correlation coefficient analysis, seasonal index and seasonal analysis demonstrated significant relationships among climatic factors, mosquito population and malaria disease incidence in the district of Visakhapatnam, India. Multiple regression and ARIMA (I) models are best suited models for modeling and prediction of disease incidences and mosquito population. Predicted values of average temperature, mosquito population and malarial cases increased along with the year. Developed MTM algorithm observed a major MTM cycle following the June to August rains and occurring between June to September and minor MTM cycles following March to April rains and occurring between March to April in the district of Visakhapatnam. Fluctuations in climatic factors favored an increase in mosquito populations and thereby increasing the number of malarial cases. Rainfall, temperatures (20°C to 33°C) and humidity (66% to 81%) maintained a warmer, wetter climate for mosquito growth, parasite development and malaria transmission. Changes in climatic factors influence malaria directly by modifying the behaviour and geographical distribution of vectors and by changing the length of the life cycle of the parasite.

Association of Climatic Variability, Vector Population and Malarial Disease in District of Visakhapatnam, India: A Modeling and Prediction Analysis

PubMed Central

Srimath-Tirumula-Peddinti, Ravi Chandra Pavan Kumar; Neelapu, Nageswara Rao Reddy; Sidagam, Naresh

2015-01-01

Background Malarial incidence, severity, dynamics and distribution of malaria are strongly determined by climatic factors, i.e., temperature, precipitation, and relative humidity. The objectives of the current study were to analyse and model the relationships among climate, vector and malaria disease in district of Visakhapatnam, India to understand malaria transmission mechanism (MTM). Methodology Epidemiological, vector and climate data were analysed for the years 2005 to 2011 in Visakhapatnam to understand the magnitude, trends and seasonal patterns of the malarial disease. Statistical software MINITAB ver. 14 was used for performing correlation, linear and multiple regression analysis. Results/Findings Perennial malaria disease incidence and mosquito population was observed in the district of Visakhapatnam with peaks in seasons. All the climatic variables have a significant influence on disease incidence as well as on mosquito populations. Correlation coefficient analysis, seasonal index and seasonal analysis demonstrated significant relationships among climatic factors, mosquito population and malaria disease incidence in the district of Visakhapatnam, India. Multiple regression and ARIMA (I) models are best suited models for modeling and prediction of disease incidences and mosquito population. Predicted values of average temperature, mosquito population and malarial cases increased along with the year. Developed MTM algorithm observed a major MTM cycle following the June to August rains and occurring between June to September and minor MTM cycles following March to April rains and occurring between March to April in the district of Visakhapatnam. Fluctuations in climatic factors favored an increase in mosquito populations and thereby increasing the number of malarial cases. Rainfall, temperatures (20°C to 33°C) and humidity (66% to 81%) maintained a warmer, wetter climate for mosquito growth, parasite development and malaria transmission. Conclusions/Significance Changes in climatic factors influence malaria directly by modifying the behaviour and geographical distribution of vectors and by changing the length of the life cycle of the parasite. PMID:26110279

Chronic cardiovascular disease mortality in mountaintop mining areas of central Appalachian states.

PubMed

Esch, Laura; Hendryx, Michael

2011-01-01

To determine if chronic cardiovascular disease (CVD) mortality rates are higher among residents of mountaintop mining (MTM) areas compared to mining and nonmining areas, and to examine the association between greater levels of MTM surface mining and CVD mortality. Age-adjusted chronic CVD mortality rates from 1999 to 2006 for counties in 4 Appalachian states where MTM occurs (N = 404) were linked with county coal mining data. Three groups of counties were compared: MTM, coal mining but not MTM, and nonmining. Covariates included smoking rate, rural-urban status, percent male population, primary care physician supply, obesity rate, diabetes rate, poverty rate, race/ethnicity rates, high school and college education rates, and Appalachian county. Linear regression analyses examined the association of mortality rates with mining in MTM areas and non-MTM areas and the association of mortality with quantity of surface coal mined in MTM areas. Prior to covariate adjustment, chronic CVD mortality rates were significantly higher in both mining areas compared to nonmining areas and significantly highest in MTM areas. After adjustment, mortality rates in MTM areas remained significantly higher and increased as a function of greater levels of surface mining. Higher obesity and poverty rates and lower college education rates also significantly predicted CVD mortality overall and in rural counties. MTM activity is significantly associated with elevated chronic CVD mortality rates. Future research is necessary to examine the socioeconomic and environmental impacts of MTM on health to reduce health disparities in rural coal mining areas. © 2011 National Rural Health Association.

Potential Health Implications of Medication Therapy Management Eligibility Criteria in the Patient Protection and Affordable Care Act Across Racial and Ethnic Groups.

PubMed

Wang, Junling; Qiao, Yanru; Shih, Ya-Chen Tina; Jarrett-Jamison, JoEllen; Spivey, Christina A; Wan, Jim Y; White-Means, Shelley I; Dagogo-Jack, Samuel; Cushman, William C; Chisholm-Burns, Marie

2015-11-01

The Medicare Prescription Drug, Improvement, and Modernization Act requires Part D plans to establish programs to provide medication therapy management (MTM) services starting from 2006. MTM services have been found to improve patient outcomes from pharmacotherapy, reduce emergency room visits and hospitalizations, and reduce health care costs in a cost-effective fashion. However, previous research found that non-Hispanic blacks (blacks) and Hispanics may be less likely to be eligible for MTM services than non-Hispanic whites (whites) among the Medicare population, according to current Medicare MTM eligibility criteria. This finding is because Medicare MTM eligibility criteria are predominantly based on medication use and costs, and blacks and Hispanics tend to use fewer prescription medications and incur lower prescription medication costs. The Patient Protection and Affordable Care Act (PPACA) laid out a set of MTM eligibility criteria for eligible entities to target patients for MTM services: "(1) take 4 or more prescribed medications ...; (2) take any 'high risk' medications; (3) have 2 or more chronic diseases ... or (4) have undergone a transition of care, or other factors ... that are likely to create a high risk of medication-related problems." To (a) examine racial/ethnic disparities in meeting the eligibility criteria for MTM services in PPACA among the Medicare population and (b) determine whether there would be greater disparities in health and economic outcomes among MTM-ineligible than MTM-eligible groups. This was a retrospective cross-sectional analysis of the Medicare Current Beneficiaries Survey (2007-2008). To determine medication characteristics, the U.S. Food and Drug Administration's Electronic Orange Book was also used. Proportions of the population eligible for MTM services based on PPACA MTM eligibility criteria were compared across racial and ethnic groups using a chi-square test; a logistic regression model was used to adjust for population sociodemographic and health characteristics. Health and economic outcomes examined included health status (self-perceived good health status, number of chronic diseases, activities of daily living [ADLs], and instrumental activities of daily living [IADLs]), health services utilization and costs (physician visits, emergency room visits, and total health care costs), and medication use patterns (generic dispensing ratio). To determine difference in disparities across MTM eligibility categories, difference-in-differences regressions of various functional forms were employed, depending on the nature of the dependent variables. Interaction terms between the dummy variables for minority groups (e.g., blacks or Hispanics) and MTM eligibility were included to test whether disparity patterns varied between MTM-ineligible and MTM-eligible individuals. The sample consisted of 12,966 Medicare beneficiaries, of which 11,161 were white, 930 were black, and 875 were Hispanic. Of the study sample, 9,992 whites (86.4%), 825 blacks (86.3%), and 733 Hispanics (80.6%) were eligible for MTM. The difference between whites and Hispanics was significant (P  less than  0.050), and the difference between whites and blacks was not significant (P  greater than 0.050). In multivariate analyses, significant disparity in eligibility for MTM services was found only between Hispanics and whites (odds ratio [OR] = 0.59; 95% CI = 0.43-0.82) but not between blacks and whites (OR = 0.78; 95% CI = 0.55-1.09). Disparities were greater among the MTM-ineligible than the MTM-eligible populations in self-perceived health status, ADLs, and IADLs for both blacks and Hispanics compared with whites. When analyzing the number of chronic conditions, the number and costs of physician visits, and total health care costs, the authors of this study found lower racial and ethnic disparities among the ineligible population than the eligible population. Hispanics are significantly less likely than whites to qualify for MTM among the Medicare population, according to MTM eligibility criteria stipulated in the PPACA. PPACA MTM eligibility criteria may aggravate existing racial and ethnic disparities in health status but may remediate racial and ethnic disparities in health services utilization. Alternative MTM eligibility criteria other than PPACA MTM eligibility criteria may be needed to improve the efficiency and equity of access to Medicare Part D MTM programs.

Pharmacy technician involvement in community pharmacy medication therapy management.

PubMed

Lengel, Matthew; Kuhn, Catherine H; Worley, Marcia; Wehr, Allison M; McAuley, James W

To assess the impact of technician involvement on the completion of medication therapy management (MTM) services in a community pharmacy setting and to describe pharmacists' and technicians' perceptions of technician involvement in MTM-related tasks and their satisfaction with the technician's role in MTM. Prospective observational study. In the fall of 2015, pharmacists and selected technicians from 32 grocery store-based community pharmacies were trained to use technicians within MTM services. Completed MTM claims were evaluated at all pharmacies for 3 months before training and 3 months after training. An electronic survey, developed with the use of competencies taught in the training and relevant published literature, was distributed via e-mail to trained employees 3 months after training. The total number of completed MTM claims at the 32 pharmacy sites was higher during the posttraining time period (2687 claims) versus the pretraining period (1735 claims). Of the 182 trained participants, 112 (61.5%) completed the survey. Overall, perceived technician involvement was lower than expected. However, identifying MTM opportunities was the most commonly reported technician MTM task, with 62.5% of technicians and 47.2% of pharmacists reporting technician involvement. Nearly one-half of technicians (42.5%) and pharmacists (44.0%) agreed or strongly agreed they were satisfied with the technician's role in MTM services, and 40.0% of technicians agreed that they were more satisfied with their work in the pharmacy after involvement in MTM. Three months after initial training of technicians in MTM, participation of technicians was lower than expected. However, the technicians involved most often reported identifying MTM opportunities for pharmacists, which may be a focus for future technician trainings. In addition, technician involvement in MTM services may increase satisfaction with many aspects of work for actively involved technicians. Copyright © 2018 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Use of manometric temperature measurement (MTM) and SMART freeze dryer technology for development of an optimized freeze-drying cycle.

PubMed

Gieseler, Henning; Kramer, Tony; Pikal, Michael J

2007-12-01

This report provides, for the first time, a summary of experiments using SMART Freeze Dryer technology during a 9 month testing period. A minimum ice sublimation area of about 300 cm(2) for the laboratory freeze dryer, with a chamber volume 107.5 L, was found consistent with data obtained during previous experiments with a smaller freeze dryer (52 L). Good reproducibility was found for cycle design with different type of excipients, formulations, and vials used. SMART primary drying end point estimates were accurate in the majority of the experiments, but showed an over prediction of primary cycle time when the product did not fully achieve steady state conditions before the first MTM measurement was performed. Product resistance data for 5% sucrose mixtures at varying fill depths were very reproducible. Product temperature determined by SMART was typically in good agreement with thermocouple data through about 50% of primary drying time, with significant deviations occurring near the end of primary drying, as expected, but showing a bias much earlier in primary drying for high solid content formulations (16.6% Pfizer product) and polyvinylpyrrolidone (40 kDa) likely due to water "re-adsorption" by the amorphous product during the MTM test. (c) 2007 Wiley-Liss, Inc.

Positioning and integrating medication therapy management.

PubMed

Schommer, Jon C; Doucette, William R; Johnson, Kathleen A; Planas, Lourdes G

2012-01-01

To summarize findings from medication therapy management (MTM) "environmental scans" conducted from 2007 through 2010, interpret findings from the environmental scans using insights gained from the Future of MTM Roundtable convened in October 2010, and propose ideas for future positioning and integrating of MTM programs in the U.S. health care system. Data for the environmental scans were collected from purposive samples of MTM pharmacist providers and MTM payers throughout the United States using self-administered online surveys in 2007, 2008, 2009, and 2010. Based on the findings, it appears that MTM is becoming more developed and that some aspects of MTM have become established within the organizations that are providing and paying for these programs. However, the findings also revealed that a need exists to better integrate MTM between organizations and patients serviced (business-to-consumer relationships), between partnering organizations (business-to-business relationships), and between collaborating practitioners (peer-to-peer relationships). The findings suggest that a "channel of distribution" is emerging in which organizational relationships and cost efficiencies will be important considerations in the near term. We propose that applying (1) customer portfolio management and (2) transaction cost economics would help improve positioning and integrating MTM into the U.S. health care system.

Drosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functions.

PubMed

Velichkova, Michaella; Juan, Joe; Kadandale, Pavan; Jean, Steve; Ribeiro, Inês; Raman, Vignesh; Stefan, Chris; Kiger, Amy A

2010-08-09

Reversible phosphoinositide phosphorylation provides a dynamic membrane code that balances opposing cell functions. However, in vivo regulatory relationships between specific kinases, phosphatases, and phosphoinositide subpools are not clear. We identified myotubularin (mtm), a Drosophila melanogaster MTM1/MTMR2 phosphoinositide phosphatase, as necessary and sufficient for immune cell protrusion formation and recruitment to wounds. Mtm-mediated turnover of endosomal phosphatidylinositol 3-phosphate (PI(3)P) pools generated by both class II and III phosphatidylinositol 3-kinases (Pi3K68D and Vps34, respectively) is needed to down-regulate membrane influx, promote efflux, and maintain endolysosomal homeostasis. Endocytosis, but not endolysosomal size, contributes to cortical remodeling by mtm function. We propose that Mtm-dependent regulation of an endosomal PI(3)P pool has separable consequences for endolysosomal homeostasis and cortical remodeling. Pi3K68D depletion (but not Vps34) rescues protrusion and distribution defects in mtm-deficient immune cells and restores functions in other tissues essential for viability. The broad interactions between mtm and class II Pi3K68D suggest a novel strategy for rebalancing PI(3)P-mediated cell functions in MTM-related human disease.

Navigating complex patients using an innovative tool: the MTM Spider Web.

PubMed

Morello, Candis M; Hirsch, Jan D; Lee, Kelly C

2013-01-01

To introduce a teaching tool that can be used to assess the complexity of medication therapy management (MTM) patients, prioritize appropriate interventions, and design patient-centered care plans for each encounter. MTM patients are complex as a result of multiple comorbidities, medications, and socioeconomic and behavioral issues. Pharmacists who provide MTM services are required to synthesize a plethora of information (medical and nonmedical), evaluate and prioritize the clinical problems, and design a comprehensive patient-centered care plan. The MTM Spider Web is a visual tool to facilitate this process. A description is provided regarding how to build the MTM Spider Web using case-based scenarios. This model can be used to teach pharmacists, health professional students, and patients. The MTM Spider Web is an innovative teaching tool that can be used to teach pharmacists and students how to assess complex patients and design a patient-centered care plan to deliver the most appropriate medication therapy.

75 FR 440 - Notice of Proposed Reinstatement of Terminated Oil and Gas Lease MTM 91625

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-05

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLMT922200-10-L13100000-FI0000-P;MTM 91625] Notice of Proposed Reinstatement of Terminated Oil and Gas Lease MTM 91625 AGENCY: Bureau of Land... for reinstatement of noncompetitive oil and gas lease MTM 91625, Musselshell County, Montana. The...

75 FR 76753 - Notice of Proposed Reinstatement of Terminated Oil and Gas Lease MTM 91627

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-09

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLMT922200-11-L13100000-FI0000-P;MTM 91627] Notice of Proposed Reinstatement of Terminated Oil and Gas Lease MTM 91627 AGENCY: Bureau of Land... for reinstatement of noncompetitive oil and gas lease MTM 91627, Musselshell County, Montana. The...

Generating demand for pharmacist-provided medication therapy management: identifying patient-preferred marketing strategies.

PubMed

Garcia, Gladys M; Snyder, Margie E; McGrath, Stephanie Harriman; Smith, Randall B; McGivney, Melissa Somma

2009-01-01

To identify effective strategies for marketing pharmacist-provided medication therapy management (MTM) services to patients in a self-insured employer setting. Qualitative study. University of Pittsburgh during March through May 2008. 26 university employees taking at least one chronic medication. Three focus group sessions were conducted using a semistructured topic guide to facilitate the discussion. Employees' perceived medication-related needs, perceived benefits of pharmacist-provided MTM, potential barriers for employee participation in MTM, and effective strategies for marketing MTM. Participants reported concerns with timing of doses, medication costs, access, and ensuring adherence. Participants generally felt positively toward pharmacists; however, the level of reported patient contact with pharmacists varied among participants. Some participants questioned pharmacists' education and qualifications for this enhanced role in patient care. Perceived benefits of MTM noted by participants included the opportunity to obtain personalized information about their medications and the potential for improved communication among their health providers. Barriers to patient participation were out-of-pocket costs and lack of time for MTM visits. Participants suggested use of alternative words to describe MTM and marketing approaches that involve personal contact. Pharmacists should emphasize parts of MTM that patients feel are most beneficial (i.e., provision of a personal medication record) and use patient-friendly language to describe MTM when marketing their practice. Patients will need greater exposure to the concept of MTM and the pharmacists' role in order to correctly describe and assign value to this type of pharmacist patient care practice.

76 FR 10389 - Notice of Proposed Reinstatement of Terminated Oil and Gas lease MTM 96122

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-24

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLMT922200-11-L13100000-FI0000-P;MTM 96122] Notice of Proposed Reinstatement of Terminated Oil and Gas lease MTM 96122 AGENCY: Bureau of Land... filed a petition for reinstatement of competitive oil and gas lease MTM 96122, Richland County, Montana...

76 FR 54484 - Notice of Proposed Reinstatement of Terminated Oil and Gas Lease MTM 98742

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-01

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLMT922200-11-L13100000-FI0000-P;MTM 98742] Notice of Proposed Reinstatement of Terminated Oil and Gas Lease MTM 98742 AGENCY: Bureau of Land... petition for reinstatement of competitive oil and gas lease MTM 98742, Fergus County, Montana. The lessee...

75 FR 63855 - Notice of Proposed Reinstatement of Terminated Oil and Gas Lease MTM 98742, Montana

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-18

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLMT922200-10-L13100000-FI0000-P;MTM 98742] Notice of Proposed Reinstatement of Terminated Oil and Gas Lease MTM 98742, Montana AGENCY: Bureau of... lease MTM 98742, for land in Fergus County, Montana. The lessee paid the required rental accruing from...

75 FR 30059 - Notice of Proposed Reinstatement of Terminated Oil and Gas Lease MTM 98343

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-28

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLMT922200-10-L13100000-FI0000-P; MTM 98343] Notice of Proposed Reinstatement of Terminated Oil and Gas Lease MTM 98343 AGENCY: Bureau of Land... petition for reinstatement of competitive oil and gas lease MTM 98343, Fergus County, Montana. The lessee...

75 FR 43553 - Notice of Proposed Reinstatement of Terminated Oil and Gas Lease MTM 97827, Montana

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-26

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLMT922200-10-L13100000-FI0000-P;MTM 97827] Notice of Proposed Reinstatement of Terminated Oil and Gas Lease MTM 97827, Montana AGENCY: Bureau of... and gas lease MTM 97827, Carbon County, Montana. The lessee paid the required rental accruing from the...

Physicians' Preferences for Communication of Pharmacist-Provided Medication Therapy Management in Community Pharmacy.

PubMed

Guthrie, Kendall D; Stoner, Steven C; Hartwig, D Matthew; May, Justin R; Nicolaus, Sara E; Schramm, Andrew M; DiDonato, Kristen L

2017-02-01

(1) To identify physicians' preferences in regard to pharmacist-provided medication therapy management (MTM) communication in the community pharmacy setting; (2) to identify physicians' perceived barriers to communicating with a pharmacist regarding MTM; and (3) to determine whether Missouri physicians feel MTM is beneficial for their patients. A cross-sectional prospective survey study of 2021 family and general practice physicians registered with MO HealthNet, Missouri's Medicaid program. The majority (52.8%) of physicians preferred MTM data to be communicated via fax. Most physicians who provided care to patients in long-term care (LTC) facilities (81.0%) preferred to be contacted at their practice location as opposed to the LTC facility. The greatest barriers to communication were lack of time and inefficient communication practices. Improved/enhanced communication was the most common suggestion for improvement in the MTM process. Approximately 67% of respondents reported MTM as beneficial or somewhat beneficial for their patients. Survey respondents saw value in the MTM services offered by pharmacists. However, pharmacists should use the identified preferences and barriers to improve their currently utilized communication practices in hopes of increasing acceptance of recommendations. Ultimately, this may assist MTM providers in working collaboratively with patients' physicians.

Optimization of PET-MR Registrations for Nonhuman Primates Using Mutual Information Measures: A Multi-Transform Method (MTM)

PubMed Central

Sandiego, Christine M.; Weinzimmer, David; Carson, Richard E.

2012-01-01

An important step in PET brain kinetic analysis is the registration of functional data to an anatomical MR image. Typically, PET-MR registrations in nonhuman primate neuroreceptor studies used PET images acquired early post-injection, (e.g., 0–10 min) to closely resemble the subject’s MR image. However, a substantial fraction of these registrations (~25%) fail due to the differences in kinetics and distribution for various radiotracer studies and conditions (e.g., blocking studies). The Multi-Transform Method (MTM) was developed to improve the success of registrations between PET and MR images. Two algorithms were evaluated, MTM-I and MTM-II. The approach involves creating multiple transformations by registering PET images of different time intervals, from a dynamic study, to a single reference (i.e., MR image) (MTM-I) or to multiple reference images (i.e., MR and PET images pre-registered to the MR) (MTM-II). Normalized mutual information was used to compute similarity between the transformed PET images and the reference image(s) to choose the optimal transformation. This final transformation is used to map the dynamic dataset into the animal’s anatomical MR space, required for kinetic analysis. The chosen transformed from MTM-I and MTM-II were evaluated using visual rating scores to assess the quality of spatial alignment between the resliced PET and reference. One hundred twenty PET datasets involving eleven different tracers from 3 different scanners were used to evaluate the MTM algorithms. Studies were performed with baboons and rhesus monkeys on the HR+, HRRT, and Focus-220. Successful transformations increased from 77.5%, 85.8%, to 96.7% using the 0–10 min method, MTM-I, and MTM-II, respectively, based on visual rating scores. The Multi-Transform Methods proved to be a robust technique for PET-MR registrations for a wide range of PET studies. PMID:22926293

Application of advanced structure to multi-tone mask for FPD process

NASA Astrophysics Data System (ADS)

Song, Jin-Han; Jeong, Jin-Woong; Kim, Kyu-Sik; Jeong, Woo-Gun; Yun, Sang-Pil; Lee, Dong-Heok; Choi, Sang-Soo

2017-07-01

In accordance with improvement of FPD technology, masks such as phase shift mask (PSM) and multi-tone mask (MTM) for a particular purpose also have been developed. Above all, the MTM consisted of more than tri-tone transmittance has a substantial advantage which enables to reduce the number of mask demand in FPD fabrication process contrast to normal mask of two-tone transmittance.[1,2] A chromium (Cr)-based MTM (Typically top type) is being widely employed because of convenience of etch process caused by its only Cr-based structure consisted of Cr absorber layer and Cr half-tone layer. However, the top type of Cr-based MTM demands two Cr sputtering processes after each layer etching process and writing process. For this reason, a different material from the Cr-based MTM is required for reduction of mask fabrication time and cost. In this study, we evaluate a MTM which has a structure combined Cr with molybdenum silicide (MoSi) to resolve the issues mentioned above. The MoSi which is demonstrated by integrated circuit (IC) process is a suitable material for MTM evaluation. This structure could realize multi-transmittance in common with the Cr-based MTM. Moreover, it enables to reduce the number of sputtering process. We investigate a optimized structure upon consideration of productivity along with performance such as critical dimension (CD) variation and transmittance range of each structure. The transmittance is targeted at h-line wavelength (405 nm) in the evaluation. Compared with Cr-based MTM, the performances of all Cr-/MoSi-based MTMs are considered.

Developing a dashboard for benchmarking the productivity of a medication therapy management program.

PubMed

Umbreit, Audrey; Holm, Emily; Gander, Kelsey; Davis, Kelsie; Dittrich, Kristina; Jandl, Vanda; Odell, Laura; Sweeten, Perry

To describe a method for internal benchmarking of medication therapy management (MTM) pharmacist activities. Multisite MTM pharmacist practices within an integrated health care system. MTM pharmacists are located within primary care clinics and provide medication management through collaborative practice. MTM pharmacist activity is grouped into 3 categories: direct patient care, nonvisit patient care, and professional activities. MTM pharmacist activities were tracked with the use of the computer-based application Pharmacist Ambulatory Resource Management System (PhARMS) over a 12-month period to measure growth during a time of expansion. A total of 81% of MTM pharmacist time was recorded. A total of 1655.1 hours (41%) was nonvisit patient care, 1185.2 hours (29%) was direct patient care, and 1190.4 hours (30%) was professional activities. The number of patient visits per month increased during the study period. There were 1496 direct patient care encounters documented. Of those, 1051 (70.2%) were face-to-face visits, 257 (17.2%) were by telephone, and 188 (12.6%) were chart reviews. Nonvisit patient care and professional activities also increased during the period. PhARMS reported MTM pharmacist activities and captured nonvisit patient care work not tracked elsewhere. Internal benchmarking data proved to be useful for justifying increases in MTM pharmacist personnel resources. Reviewing data helped to identify best practices from high-performing sites. Limitations include potential for self-reporting bias and lack of patient outcomes data. Implementing PhARMS facilitated internal benchmarking of patient care and nonpatient care activities in a regional MTM program. Copyright © 2017 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Assessing Medicare beneficiaries' willingness-to-pay for medication therapy management services.

PubMed

Woelfel, Joseph A; Carr-Lopez, Sian M; Delos Santos, Melanie; Bui, Ann; Patel, Rajul A; Walberg, Mark P; Galal, Suzanne M

2014-02-01

To assess Medicare beneficiaries' willingness-to-pay (WTP) for medication therapy management (MTM) services and determine sociodemographic and clinical characteristics influencing this payment amount. A cross-sectional, descriptive study design was adopted to elicit Medicare beneficiaries' WTP for MTM. Nine outreach events in cities across Central/Northern California during Medicare's 2011 open-enrollment period. A total of 277 Medicare beneficiaries participated in the study. Comprehensive MTM was offered to each beneficiary. Pharmacy students conducted the MTM session under the supervision of licensed pharmacists. At the end of each MTM session, beneficiaries were asked to indicate their WTP for the service. Medication, self-reported chronic conditions, and beneficiary demographic data were collected and recorded via a survey during the session. The mean WTP for MTM was $33.15 for the 277 beneficiaries receiving the service and answering the WTP question. WTP by low-income subsidy recipients (mean ± standard deviation; $12.80 ± $24.10) was significantly lower than for nonsubsidy recipients ($41.13 ± $88.79). WTP was significantly (positively) correlated with number of medications regularly taken and annual out-of-pocket drug costs. The mean WTP for MTM was $33.15. WTP for MTM significantly varied by race, subsidy status, and number of prescription medications taken. WTP was significantly higher for nonsubsidy recipients than subsidy recipients, and significantly positively correlated with the number of medications regularly taken and the beneficiary rating of the delivered services.

Analysis of pharmacist-provided medication therapy management (MTM) services in community pharmacies over 7 years.

PubMed

Barnett, Mitchell J; Frank, Jessica; Wehring, Heidi; Newland, Brand; VonMuenster, Shannon; Kumbera, Patty; Halterman, Tom; Perry, Paul J

2009-01-01

Although community pharmacists have historically been paid primarily for drug distribution and dispensing services, medication therapy management (MTM) services evolved in the 1990s as a means for pharmacists and other providers to assist physicians and patients in managing clinical, service, and cost outcomes of drug therapy. The Medicare Prescription Drug, Improvement, and Modernization Act of 2003 (MMA 2003) and the subsequent implementation of Medicare Part D in January 2006 for the more than 20 million Medicare beneficiaries enrolled in the Part D benefit formalized MTM services for a subset of high-cost patients. Although Medicare Part D has provided a new opportunity for defining the value of pharmacist-provided MTM services in the health care system, few publications exist which quantify changes in the provision of pharmacist-provided MTM services over time. To (a) describe the changes over a 7-year period in the primary types of MTM services provided by community pharmacies that have contracted with drug plan sponsors through an MTM administrative services company, and (b) quantify potential MTM-related cost savings based on pharmacists' self-assessments of the likely effects of their interventions on health care utilization. Medication therapy management claims from a multistate MTM administrative services company were analyzed over the 7-year period from January 1, 2000, through December 31, 2006. Data extracted from each MTM claim included patient demographics (e.g., age and gender), the drug and type that triggered the intervention (e.g., drug therapeutic class and therapy type as either acute, intermittent, or chronic), and specific information about the service provided (e.g., Reason, Action, Result, and Estimated Cost Avoidance [ECA]). ECA values are derived from average national health care utilization costs, which are applied to pharmacist self-assessment of the "reasonable and foreseeable" outcome of the intervention. ECA values are updated annually for medical care inflation. From a database of nearly 100,000 MTM claims, a convenience sample of 50 plan sponsors was selected. After exclusion of claims with missing or potentially duplicate data, there were 76,148 claims for 23,798 patients from community pharmacy MTM providers in 47 states. Over the 7-year period from January 1, 2000, through December 31, 2006, the mean ([SD] median) pharmacy reimbursement was $8.44 ([$5.19] $7.00) per MTM service, and the mean ([SD] median) ECA was $93.78 ([$1,022.23] $5.00). During the 7-year period, pharmacist provided MTM interventions changed from primarily education and monitoring for new or changed prescription therapies to prescriber consultations regarding cost-efficacy management (Pearson chi-square P<0.001). Services also shifted from claims involving acute medications (e.g. penicillin antibiotics, macrolide antibiotics, and narcotic analgesics) to services involving chronic medications (e.g., lipid lowering agents, angiotensin-converting enzyme [ACE] inhibitors, and beta-blockers; P<0.001), resulting in significant changes in the therapeutic classes associated with MTM claims and an increase in the proportion of older patients served (P<0.001). These trends resulted in higher pharmacy reimbursements and greater ECA per claim over time (P<0.001). MTM interventions over a 7-year period evolved from primarily the provision of patient education involving acute medications towards consultation-type services for chronic medications. These changes were associated with increases in reimbursement amounts and pharmacist-estimated cost savings. It is uncertain if this shift in service type is a result of clinical need, documentation requirements, or reimbursement opportunities.

Contingent valuation and pharmacists' acceptable levels of compensation for medication therapy management services.

PubMed

Wang, Junling; Hong, Song Hee

2015-01-01

Pharmacists' acceptable level of compensation for medication therapy management (MTM) services needs to be determined using various economic evaluation techniques. Using contingent valuation method, determine pharmacists' acceptable levels of compensation for MTM services. A mailing survey was used to elicit Tennessee (U.S.) pharmacists' acceptable levels of compensation for a 30-minute MTM session for a new patient with 2 medical conditions, 8 medications, and an annual drug cost of $2000. Three versions of a series of double-bounded, closed-ended, binary discrete choice questions were asked of pharmacists for their willingness to accept (WTA) for an original monetary value ($30, $60, or $90) and then follow-up higher or lower value depending on their responses to the original value. A Kaplan-Meier approach was taken to analyze pharmacists' WTA, and Cox's proportional hazards model was used to examine the effects of pharmacist characteristics on their WTA. Three hundred and forty-eight pharmacists responded to the survey. Pharmacists' WTA for the given MTM session had a mean of $63.31 and median of $60. The proportions of pharmacists willing to accept $30, $60, and $90 for the given MTM session were 30.61%, 85.19%, and 91.01%, respectively. Pharmacists' characteristics had statistically significant association with their WTA rates. Pharmacists' WTA for the given MTM session is higher than current Medicare MTM programs' compensation levels of $15-$50 and patients' willingness to pay of less than $40. Besides advocating for higher MTM compensation levels by third-party payers, pharmacists also may need to charge patients to reach sufficient compensation levels for MTM services. Copyright © 2015 Elsevier Inc. All rights reserved.

Contingent Valuation and Pharmacists' Acceptable Levels of Compensation for Medication Therapy Management Services

PubMed Central

Wang, Junling; Hong, Song Hee

2012-01-01

Background Pharmacists' acceptable level of compensation for medication therapy management (MTM) services needs to be determined using various economic evaluation techniques. Objectives Using contingent valuation method, determine pharmacists' acceptable levels of compensation for MTM services. Methods A mailing survey was used to elicit Tennessee (US) pharmacists' acceptable levels of compensation for a 30-minute MTM session for a new patient with 2 medical conditions, 8 medications, and an annual drug cost of $2,000. Three versions of a series of double-bounded, closed-ended, binary discrete choice questions were asked of pharmacists for their willingness-to-accept (WTA) for an original monetary value ($30, $60, or $90) and then follow-up higher or lower value depending on their responses to the original value. A Kaplan-Meier approach was taken to analyze pharmacists' WTA, and Cox's proportional hazards model was used to examine the effects of pharmacist characteristics on their WTA. Results Three hundred and forty-eight pharmacists responded to the survey. Pharmacists' WTA for the given MTM session had a mean of $63.31 and median of $60. The proportions of pharmacists willing to accept $30, $60, and $90 for the given MTM session were 30.61%, 85.19%, and 91.01%, respectively. Pharmacists' characteristics had statistically significant association with their WTA rates. Conclusions Pharmacists' WTA for the given MTM session is higher than current Medicare MTM programs' compensation levels of $15 to $50 and patients' willingness-to-pay of less than $40. Besides advocating for higher MTM compensation levels by third-party payers, pharmacists also may need to charge patients to reach sufficient compensation levels for MTM services. PMID:22436583

Medication Therapy Management in community pharmacy practice: core elements of an MTM service (version 1.0).

PubMed

2005-01-01

To develop a model framework of Medication Therapy Management (MTM) in community pharmacy designed to improve care, enhance communication among patients and providers, improve collaboration among providers, and optimize medication use that leads to improved patient outcomes. Peer-reviewed literature, structured discussions with community pharmacy leaders and representatives from pharmacy benefit providers and health plans, and input from pharmacists and pharmacy associations. Building on an MTM consensus definition adopted by 11 national pharmacy organizations in July 2004, this model describes core elements of an MTM service that can be provided by pharmacists across the spectrum of community pharmacy. The model is structured for pharmacists to use with all patients in need of MTM services, both in the private and public sector. The model describes five core elements of MTM in the community pharmacy setting: medication therapy review (MTR), a personal medication record (PMR), a medication action plan (MAP), intervention and referral, and documentation and follow-up. The MTR can be comprehensive or targeted, depending onthe needs of the patient. The PMR and MAP are patient-centered documents intended to be used by the patient to improve medication self-management. A collaborative approach to patient care involving patients, pharmacists, and physicians and other health care providers is advocated in the model. General patient eligibility considerations are also described. A model framework for consideration by community pharmacists in developing MTM services is described. The model consists of five core elements for MTM service delivery in community pharmacy practice.

Comparison of two Medication Therapy Management Practice Models on Return on Investment.

PubMed

Gazda, Nicholas P; Berenbrok, Lucas A; Ferreri, Stefanie P

2017-06-01

To compare the return on investment (ROI) of an integrated practice model versus a "hub and spoke" practice model of pharmacist provided medication therapy management (MTM). A cohort retrospective analysis of MTM claims billed in 76 pharmacies in North Carolina in the 2010 hub and spoke practice model and the 2012 "integrated" practice model were analyzed to calculate the ROI. In 2010, 4089 patients received an MTM resulting in 8757 claims in the hub and spoke model. In 2012, 4896 patients received an MTM resulting in 13 730 claims in the integrated model. In 2010, US$165 897.26 was invested in pharmacist salary and $173 498.00 was received in reimbursement, resulting in an ROI of +US$7600.74 (+4.6%). In 2012, US$280 890.09 was invested in pharmacist salary and US$302 963 was received in reimbursement, resulting in an ROI of +US$22 072.91 or (+7.9%). The integrated model of MTM showed an increase in number of claims submitted and in number of patients receiving MTM services, ultimately resulting in a higher ROI. While a higher ROI was evident in the integrated model, both models resulted in positive ROI (1:12-1:21), highlighting that MTM programs can be cost effective with different strategies of execution.

Impact of medication therapy management on underserved, primarily Hispanic patients with diabetes.

PubMed

Congdon, Heather B; Dowling, Thomas C; Cheng, Iliana; Truong, Hoai-An

2013-05-01

Diabetes-related complications are more pronounced in Hispanic patients versus patients of other ethnicities. It is documented that medication therapy management (MTM) can improve diabetes outcomes; however, data regarding Hispanic patients are limited. To evaluate the impact of MTM on hemoglobin A1c (A1C), blood pressure (BP), and low-density lipoprotein cholesterol (LDL-C) in underserved, primarily Hispanic patients who use a safety-net clinic as their medical home. A retrospective, observational study of uninsured, primarily Hispanic patients with diabetes who received MTM from October 2009 through March 2011. Patients were stratified into 2 cohorts: A1C less than 9% and A1C greater than or equal to 9%. Patients were also stratified by frequency of MTM visits and insulin use, regardless of A1C. A chart review was conducted to evaluate diabetes-related outcomes pre- and postimplementation of MTM. The primary study outcome was reduction of A1C. Secondary outcomes included reduction of BP and LDL-C and reduction of A1C based on MTM visit frequency or insulin use. Sixty-four patients with at least 1 MTM visit and pre- and postimplementation A1C data were included. In the cohort with A1C greater than or equal to 9%, mean (SD) A1C values decreased from 10.9% (1.4%) to 8.8% (1.5%) versus the cohort with A1C less than 9%, whose A1C changed minimally, from 7.2% (0.9%) to 7.4% (1.4%). Regardless of their A1C, patients who were using insulin at baseline had a change in A1C of -0.8% (1.5%) versus -0.1% (1.6%) in those who were not using insulin at baseline (p = 0.04); patients who participated in multiple MTM visits had a significant reduction in A1C, from 9% to 8.3% (95% CI -1.26 to -0.03; p = 0.02) compared with patients participating in only 1 MTM visit. Pharmacist-provided MTM can significantly improve diabetes control in uninsured, primarily Hispanic patients with poorly controlled diabetes and in those who are using insulin. Multiple MTM visits also yielded significant A1C reductions.

Racial and ethnic disparities in meeting MTM eligibility criteria among patients with asthma.

PubMed

Lu, Degan; Qiao, Yanru; Johnson, Karen C; Wang, Junling

2017-06-01

Asthma is one of the most frequently targeted chronic diseases in the medication therapy management (MTM) programs of the Medicare prescription drug (Part D) benefits. Although racial and ethnic disparities in meeting eligibility criteria for MTM services have been reported, little is known about whether there would be similar disparities among adults with asthma in the United States. Adult patients with asthma (age ≥ 18) from Medical Expenditure Panel Survey (2011-2012) were analyzed. Bivariate analyses were conducted to compare the proportions of patients who would meet Medicare MTM eligibility criteria between non-Hispanic Blacks (Blacks), Hispanics and non-Hispanic Whites (Whites). Survey-weighted logistic regression was performed to adjust for patient characteristics. Main and sensitivity analyses were conducted to cover the entire range of the eligibility thresholds used by Part D plans in 2011-2012. The sample included 4,455 patients with asthma, including 2,294 Whites, 1,218 Blacks, and 943 Hispanics. Blacks and Hispanics had lower proportions of meeting MTM eligibility criteria than did Whites (P < 0.001). According to the main analysis, Blacks and Hispanics had 36% and 32% lower, respectively, likelihood of MTM eligibility than Whites (odds ratio [OR]: 0.64, 95% confidence interval [CI]: 0.45-0.90; OR: 0.68, 95% CI: 0.47-0.98, respectively). Similar results were obtained in sensitivity analyses. There are racial and ethnic disparities in meeting Medicare Part D MTM eligibility criteria among adult patients with asthma. Future studies should examine the implications of such disparities on health outcomes of patients with asthma and explore alternative MTM eligibility criteria.

An introductory pharmacy practice experience based on a medication therapy management service model.

PubMed

Agness, Chanel F; Huynh, Donna; Brandt, Nicole

2011-06-10

To implement and evaluate an introductory pharmacy practice experience (IPPE) based on the medication therapy management (MTM) service model. Patient Care 2 is an IPPE that introduces third-year pharmacy students to the MTM service model. Students interacted with older adults to identify medication-related problems and develop recommendations using core MTM elements. Course outcome evaluations were based on number of documented medication-related problems, recommendations, and student reviews. Fifty-seven older adults participated in the course. Students identified 52 medication-related problems and 66 medical problems, and documented 233 recommendations relating to health maintenance and wellness, pharmacotherapy, referrals, and education. Students reported having adequate experience performing core MTM elements. Patient Care 2 may serve as an experiential learning model for pharmacy schools to teach the core elements of MTM and provide patient care services to the community.

Effect of Eruption Status of the Mandibular Third Molar on Distal Caries in the Adjacent Second Molar.

PubMed

Kang, Feiwu; Huang, Cheng; Sah, Manoj Kumar; Jiang, Beizhan

2016-04-01

To analyze the effect of the eruption status of the mandibular third molar (MTM) on distal caries in the mandibular second molar (MSM) by cone-beam computed tomography (CBCT). Five hundred CBCT images of MTMs from 469 patients were evaluated. Presence of distal caries in MSMs, impaction depths and angulations of MTMs, cementoenamel junction (CEJ) distances between distal MSMs and mesial MTMs, presence of pericoronitis in MTMs, and patient characteristics (age and gender) were assessed. Data were analyzed by χ(2) test, univariate and multivariate logistic regression analyses, and Spearman correlation analysis. Descriptive and bivariate statistics were computed and the P value was set at .05. The overall prevalence of distal caries in the MSM was 52.0%. According to the classification of Pell and Gregory, position A was the impaction depth at which most distal caries in MSMs were present (P = .036). For angulation of the MTM, when mesial angulations were 43° to 73°, MSMs developed more distal caries (P < .0001). For the CEJ distance between the distal MSM and the mesial MTM, when distances ranged from 6 to 15 mm, distal caries in MSMs occurred more frequently (6 to 8 mm, P < .0001; 8 to 15 mm, P = .037). Furthermore, there was a linear correlation between angulation of the MTM and the CEJ distance between the distal MSM and the mesial MTM (P < .0001). Impaction depth and angulation of the MTM are associated with distal caries in the MSM. Angulation of the MTM is more stable and reliable than the CEJ distance between the distal MSM and the mesial MTM for the estimation of risk factors related to the MTM. Copyright © 2016 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

Minutia Tensor Matrix: A New Strategy for Fingerprint Matching

PubMed Central

Fu, Xiang; Feng, Jufu

2015-01-01

Establishing correspondences between two minutia sets is a fundamental issue in fingerprint recognition. This paper proposes a new tensor matching strategy. First, the concept of minutia tensor matrix (simplified as MTM) is proposed. It describes the first-order features and second-order features of a matching pair. In the MTM, the diagonal elements indicate similarities of minutia pairs and non-diagonal elements indicate pairwise compatibilities between minutia pairs. Correct minutia pairs are likely to establish both large similarities and large compatibilities, so they form a dense sub-block. Minutia matching is then formulated as recovering the dense sub-block in the MTM. This is a new tensor matching strategy for fingerprint recognition. Second, as fingerprint images show both local rigidity and global nonlinearity, we design two different kinds of MTMs: local MTM and global MTM. Meanwhile, a two-level matching algorithm is proposed. For local matching level, the local MTM is constructed and a novel local similarity calculation strategy is proposed. It makes full use of local rigidity in fingerprints. For global matching level, the global MTM is constructed to calculate similarities of entire minutia sets. It makes full use of global compatibility in fingerprints. Proposed method has stronger description ability and better robustness to noise and nonlinearity. Experiments conducted on Fingerprint Verification Competition databases (FVC2002 and FVC2004) demonstrate the effectiveness and the efficiency. PMID:25822489

Sound Medication Therapy Management Programs, Version 2.0 with validation study.

PubMed

2008-01-01

The Academy of Managed Care Pharmacy (AMCP, the Academy) contracted with the National Committee for Quality Assurance (NCQA) to conduct a field study to validate and assess the 2006 Sound Medication Therapy Management Programs, Version 1.0 document. Version 1.0 posits several principles of sound medication therapy management (MTM) programs: they (1) recruit patients whose data show they may need assistance with managing medications; (2) have health professionals who intervene with patients and their physicians to improve medication regimens; and (3) measure their results. The validation study determined the extent to which the principles identified in version 1.0 are incorporated in MTM programs. The method was designed to determine to what extent the important features and operational elements of sound MTM programs as described in version 1.0 are (1) acceptable and seen as comprehensive to users, (2) incorporated into MTM programs in the field, (3) reflective of the consensus group's intentions, and (4) in need of modification or updating. NCQA first conducted Phase One, in which NCQA gathered perspectives on the principles in the consensus document from a mixed group of stakeholders representing both providers and users of MTM programs. Phase Two involved a deeper analysis of existing programs related to the consensus document, in which NCQA conducted a Web-based survey of 20 varied MTM programs and conducted in-depth site visits with 5 programs. NCQA selected programs offered by a range of MTM-providing organizations -- health plans, pharmacy benefit management companies, disease management organizations, and stand-alone MTM providers. NCQA analyzed the results of both phases. The Phase Two survey asked specific questions of the programs and found that some programs perform beyond the principles listed in version 1.0. NCQA found that none of the elements of the consensus document should be eliminated because programs cannot perform them, although NCQA suggested some areas where the document could be more expansive or more specific, given the state of MTM operations in the field. The important features and operational elements in the document were categorized into the following 3 overall categories, which NCQA used to structure the survey and conduct the site visits in Phase Two: (1) eligibility and enrollment, (2) operations, and (3) quality management. NCQA found that the original consensus document was realistic in identifying the elements of sound MTM. In the current project, NCQA's purpose was not to make judgments about the effectiveness of MTM programs in general or any individual program in particular. NCQA recommended that the consensus document could be made stronger and more specific in 3 areas: (1) specifically state that the Patient Identification and Recruitment section advocates use of various eligibility criteria that may include, but are not limited to, Medicare-defined MTM eligibility criteria; (2) reframe or remove the statement in Appendix A of the consensus document that the preferred modality for MTM is face-to-face interaction between patient and pharmacist, unless there are comparative data to support it as currently written; and (3) specifically recommend that programs measure performance across the entire populations in their plans in addition to measuring results for those patients selected into MTM. This will make benchmarking among programs possible and will lead to substantiated best practices in this growing field.

Review of survey articles regarding medication therapy management (MTM) services/programs in the United States.

PubMed

Oladapo, Abiola O; Rascati, Karen L

2012-08-01

To provide a summary of published survey articles regarding the provision of medication therapy management (MTM) services in the United States. A literature search was conducted to identify original articles on MTM-related surveys conducted in the United States, involving community and outpatient pharmacists, physicians, patients, or pharmacy students and published by the primary researchers who conducted the study. Search engines used included PubMed, Medline, and International Pharmaceutical Abstracts (IPA). If MTM was in the keyword list, mesh heading, title, or abstract, the article was reviewed. References from these articles were searched to determine whether other relevant articles were available. A total of 405 articles were initially reviewed; however, only 32 articles met the study requirements. Of the 32 articles, 17 surveyed community/outpatient pharmacists, 3 surveyed pharmacy students, 4 surveyed physicians, and 8 surveyed patients. The survey periods varied across the different studies, with the earliest survey conducted in 2004 and the most recent survey conducted in 2009. The surveys were conducted via the telephone, US mail, interoffice mail, e-mails, Internet/Web sites, hand-delivered questionnaires, and focus groups. Despite the identified barriers to the provision of MTM services, pharmacists reportedly found it professionally rewarding to provide these services. Pharmacists claimed to have adequate clinical knowledge, experience, and access to information required to provide MTM services. Pharmacy students were of the opinion that the provision of MTM services was important to the advancement of the pharmacy profession and in providing patients with a higher level of care. Physicians supported having pharmacists adjust patients’ drug therapy and educate patients on general drug information but not in selecting patients’ drug therapy. Finally, patients suggested that alternative ways need to be explored in describing and marketing MTM services for it to be appealing to them.

"How do I say that?": Using communication principles to enhance medication therapy management instruction.

PubMed

Denvir, Paul M; Cardone, Katie E; Parker, Wendy M; Cerulli, Jennifer

2018-02-01

Medication therapy management (MTM) is a comprehensive, patient-centered approach to improving medication use, reducing the risk of adverse events and improving medication adherence. Given the service delivery model and required outputs of MTM services, communication skills are of utmost importance. The objectives of this study were to identify and describe communication principles and instructional practices to enhance MTM training. Drawing on formative assessment data from interviews of both pharmacy educators and alumni, this article identifies and describes communication principles and instructional practices that pharmacy educators can use to enhance MTM training initiatives to develop student communication strategies. Analysis revealed five key communication challenges of MTM service delivery, two communication principles that pharmacy teachers and learners can use to address those challenges, and a range of specific strategies, derived from communication principles, that students can use when challenges emerge. Implications of the analysis for pharmacy educators and researchers are described. Proactive communication training provided during MTM advanced pharmacy practice experiences enabled students to apply the principles and instructional strategies to specific patient interactions during the advanced pharmacy practice experiences and in their post-graduation practice settings. Copyright © 2017 Elsevier Inc. All rights reserved.

Isotopic imprints of mountaintop mining contaminants.

PubMed

Vengosh, Avner; Lindberg, T Ty; Merola, Brittany R; Ruhl, Laura; Warner, Nathaniel R; White, Alissa; Dwyer, Gary S; Di Giulio, Richard T

2013-09-03

Mountaintop mining (MTM) is the primary procedure for surface coal exploration within the central Appalachian region of the eastern United States, and it is known to contaminate streams in local watersheds. In this study, we measured the chemical and isotopic compositions of water samples from MTM-impacted tributaries and streams in the Mud River watershed in West Virginia. We systematically document the isotopic compositions of three major constituents: sulfur isotopes in sulfate (δ(34)SSO4), carbon isotopes in dissolved inorganic carbon (δ(13)CDIC), and strontium isotopes ((87)Sr/(86)Sr). The data show that δ(34)SSO4, δ(13)CDIC, Sr/Ca, and (87)Sr/(86)Sr measured in saline- and selenium-rich MTM impacted tributaries are distinguishable from those of the surface water upstream of mining impacts. These tracers can therefore be used to delineate and quantify the impact of MTM in watersheds. High Sr/Ca and low (87)Sr/(86)Sr characterize tributaries that originated from active MTM areas, while tributaries from reclaimed MTM areas had low Sr/Ca and high (87)Sr/(86)Sr. Leaching experiments of rocks from the watershed show that pyrite oxidation and carbonate dissolution control the solute chemistry with distinct (87)Sr/(86)Sr ratios characterizing different rock sources. We propose that MTM operations that access the deeper Kanawha Formation generate residual mined rocks in valley fills from which effluents with distinctive (87)Sr/(86)Sr and Sr/Ca imprints affect the quality of the Appalachian watersheds.

Mapping the route to medication therapy management documentation and billing standardization and interoperabilility within the health care system: meeting proceedings.

PubMed

Millonig, Marsha K

2009-01-01

To convene a diverse group of stakeholders to discuss medication therapy management (MTM) documentation and billing standardization and its interoperability within the health care system. More than 70 stakeholders from pharmacy, health information systems, insurers/payers, quality, and standard-setting organizations met on October 7-8, 2008, in Bethesda, MD. The American Pharmacists Association (APhA) organized the invitational conference to facilitate discussion on strategic directions for meeting current market need for MTM documentation and billing interoperability and future market needs for MTM integration into electronic health records (EHRs). APhA recently adopted policy that specifically addresses technology barriers and encourages the use and development of standardized systems for the documentation and billing of MTM services. Day 1 of the conference featured six foundational presentations on health information technology (HIT) trends, perspectives on MTM from the profession and the Centers for Medicare & Medicaid Services, health care quality and medication-related outcome measures, integrating MTM workflow in EHRs, and the current state of MTM operalization in practice. After hearing presentations on day 1 and having the opportunity to pose questions to each speaker, conference participants were divided into three breakout groups on day 2. Each group met three times for 60 minutes each and discussed five questions from the perspective of a patient, provider, or payer. Three facilitators met with each of the groups and led discussion from one perspective (i.e., patient, provider, payer). Participants then reconvened as a complete group to participate in a discussion on next steps. HIT is expected to assist in delivering safe, effective, efficient, coordinated care as health professionals strive to improve the quality of care and outcomes for individual patients. The pharmacy profession is actively contributing to quality patient care through MTM services focused on identifying and preventing medication-related problems, improving medication use, and optimizing individual therapeutic outcomes. As MTM programs continue to expand within the health care system, one important limiting factor is the lack of standardization for documentation and billing of MTM services. This lack of interoperability between technology systems, software, and system platforms is presenting as a barrier to MTM service delivery for patients. APhA convened this invitational conference to identify strategic directions to address MTM documentation and billing standardization and interoperability. Participants viewed the meeting as highly successful in bringing together a unique, wide-ranging set of stakeholders, including the government, regulators, standards organizations, other health professions, technology firms, professional organizations, and practitioners, to share perspectives. They strongly encouraged the Association to continue this unique stakeholder dialogue. Participants provided a number of next-step suggestions for APhA to consider because of the event. Participants noted the pharmacy profession's success in building information technology systems for product transactions with systematic, organized, methodical thinking and the need to apply this success to patient services. A unique opportunity exists for the profession to influence and lead the HIT community in creating a workable health technology solution for MTM services. Reaching consensus on minimum data sets for each functional area--clinical, billing, quality improvement--would be a very important short-term gain. Further, participants said it was imperative for pharmacists and the pharmacy community at large to become actively engaged in HIT standards development efforts.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bosserman, Mary A.; Downey, Theresa; Noinaj, Nicholas

Baeyer–Villiger monooxygenases (BVMOs) have been shown to play key roles for the biosynthesis of important natural products. MtmOIV, a homodimeric FAD- and NADPH-dependent BVMO, catalyzes the key frame-modifying steps of the mithramycin biosynthetic pathway, including an oxidative C–C bond cleavage, by converting its natural substrate premithramycin B into mithramycin DK, the immediate precursor of mithramycin. The drastically improved protein structure of MtmOIV along with the high-resolution structure of MtmOIV in complex with its natural substrate premithramycin B are reported here, revealing previously undetected key residues that are important for substrate recognition and catalysis. Kinetic analyses of selected mutants allowed usmore » to probe the substrate binding pocket of MtmOIV and also to discover the putative NADPH binding site. This is the first substrate-bound structure of MtmOIV providing new insights into substrate recognition and catalysis, which paves the way for the future design of a tailored enzyme for the chemo-enzymatic preparation of novel mithramycin analogues.« less

Pilot study: incorporation of pharmacogenetic testing in medication therapy management services.

PubMed

Haga, Susanne B; Allen LaPointe, Nancy M; Moaddeb, Jivan; Mills, Rachel; Patel, Mahesh; Kraus, William E

2014-11-01

Aim: To describe the rationale and design of a pilot study evaluating the integration of pharmacogenetic (PGx) testing into pharmacist-delivered medication therapy management (MTM). Study rationale: Clinical delivery approaches of PGx testing involving pharmacists may overcome barriers of limited physician knowledge about and experience with testing. Study design: We will assess the addition of PGx testing to MTM services for cardiology patients taking three or more medications including simvastatin or clopidogrel. We will measure the impact of MTM plus PGx testing on drug/dose adjustment and clinical outcomes. Factors associated with delivery, such as time to prepare and conduct MTM and consult with physicians will be recorded. Additionally, patient interest and satisfaction will be measured. Anticipated results: We anticipate that PGx testing can be practically integrated into standard a MTM service, providing a viable delivery model for testing. Conclusion: Given the lack of evidence of an effective PGx delivery models, this study will provide preliminary evidence regarding a pharmacist-delivered approach.

76 FR 18778 - Notice of Proposed Reinstatement of Terminated Oil and Gas Leases MTM 89460, MTM 89461, MTM 89467...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-05

... that affect these lands. The lessee agrees to new lease terms for rentals and royalties of $10 per acre and 16\\2/3\\ percent. The lessee paid the $500 administration fee for the reinstatement of each lease... leases; The increased rental of $10 per acre; The increased royalty of 16\\2/3\\ percent; and The $163 cost...

Medication therapy management: its relationship to patient counseling, disease management, and pharmaceutical care.

PubMed

McGivney, Melissa Somma; Meyer, Susan M; Duncan-Hewitt, Wendy; Hall, Deanne L; Goode, Jean-Venable R; Smith, Randall B

2007-01-01

To delineate the relationship, including similarities and differences, between medication therapy management (MTM) and contemporary pharmacist-provided services, including patient counseling, disease management, and pharmaceutical care, to facilitate the continued evolution of commonly used language and a standard of practice across geographic areas and practice environments. Incorporation of MTM services into the array of Medicare-funded services affords an opportunity for pharmacists to develop direct patient care services in the community. Defining the role of MTM within the scope of pharmacist-provided patient care activities, including patient counseling, disease management, and all currently provided pharmacy services is essential to the delineation of a viable and sustainable practice model for pharmacists. The definitions of each of these services are offered, as well as comparisons and contrasts of the individual services. In addition to Medicare-eligible patients, MTM services are appropriate for anyone with medication-related needs. MTM is offered as an all-encompassing model that incorporates the philosophy of pharmaceutical care, techniques of patient counseling, and disease management in an environment that facilitates the direct collaboration of patients, pharmacists, and other health professionals. Defining the role of MTM within the current patient care models, including patient counseling, disease management, and all who provide pharmacy services, is essential in delineating a viable and sustainable practice model for pharmacists.

A natural history study of X-linked myotubular myopathy.

PubMed

Amburgey, Kimberly; Tsuchiya, Etsuko; de Chastonay, Sabine; Glueck, Michael; Alverez, Rachel; Nguyen, Cam-Tu; Rutkowski, Anne; Hornyak, Joseph; Beggs, Alan H; Dowling, James J

2017-09-26

To define the natural history of X-linked myotubular myopathy (MTM). We performed a cross-sectional study that included an online survey (n = 35) and a prospective, 1-year longitudinal investigation using a phone survey (n = 33). We ascertained data from 50 male patients with MTM and performed longitudinal assessments on 33 affected individuals. Consistent with existing knowledge, we found that MTM is a disorder associated with extensive morbidities, including wheelchair (86.7% nonambulant) and ventilator (75% requiring >16 hours of support) dependence. However, unlike previous reports and despite the high burden of disease, mortality was lower than anticipated (approximate rate 10%/y). Seventy-six percent of patients with MTM enrolled (mean age 10 years 11 months) were alive at the end of the study. Nearly all deaths in the study were associated with respiratory failure. In addition, the disease course was more stable than expected, with few adverse events reported during the prospective survey. Few non-muscle-related morbidities were identified, although an unexpectedly high incidence of learning disability (43%) was noted. Conversely, MTM was associated with substantial burdens on patient and caregiver daily living, reflected by missed days of school and lost workdays. MTM is one of the most severe neuromuscular disorders, with affected individuals requiring extensive mechanical interventions for survival. However, among study participants, the disease course was more stable than predicted, with more individuals surviving infancy and early childhood. These data reflect the disease burden of MTM but offer hope in terms of future therapeutic intervention. Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

A natural history study of X-linked myotubular myopathy

PubMed Central

Amburgey, Kimberly; Tsuchiya, Etsuko; de Chastonay, Sabine; Glueck, Michael; Alverez, Rachel; Nguyen, Cam-Tu; Rutkowski, Anne; Hornyak, Joseph; Beggs, Alan H.

2017-01-01

Objective: To define the natural history of X-linked myotubular myopathy (MTM). Methods: We performed a cross-sectional study that included an online survey (n = 35) and a prospective, 1-year longitudinal investigation using a phone survey (n = 33). Results: We ascertained data from 50 male patients with MTM and performed longitudinal assessments on 33 affected individuals. Consistent with existing knowledge, we found that MTM is a disorder associated with extensive morbidities, including wheelchair (86.7% nonambulant) and ventilator (75% requiring >16 hours of support) dependence. However, unlike previous reports and despite the high burden of disease, mortality was lower than anticipated (approximate rate 10%/y). Seventy-six percent of patients with MTM enrolled (mean age 10 years 11 months) were alive at the end of the study. Nearly all deaths in the study were associated with respiratory failure. In addition, the disease course was more stable than expected, with few adverse events reported during the prospective survey. Few non–muscle-related morbidities were identified, although an unexpectedly high incidence of learning disability (43%) was noted. Conversely, MTM was associated with substantial burdens on patient and caregiver daily living, reflected by missed days of school and lost workdays. Conclusions: MTM is one of the most severe neuromuscular disorders, with affected individuals requiring extensive mechanical interventions for survival. However, among study participants, the disease course was more stable than predicted, with more individuals surviving infancy and early childhood. These data reflect the disease burden of MTM but offer hope in terms of future therapeutic intervention. PMID:28842446

Comparison of spinal manipulation methods and usual medical care for acute and subacute low back pain: a randomized clinical trial.

PubMed

Schneider, Michael; Haas, Mitchell; Glick, Ronald; Stevans, Joel; Landsittel, Doug

2015-02-15

Randomized controlled trial with follow-up to 6 months. This was a comparative effectiveness trial of manual-thrust manipulation (MTM) versus mechanical-assisted manipulation (MAM); and manipulation versus usual medical care (UMC). Low back pain (LBP) is one of the most common conditions seen in primary care and physical medicine practice. MTM is a common treatment for LBP. Claims that MAM is an effective alternative to MTM have yet to be substantiated. There is also question about the effectiveness of manipulation in acute and subacute LBP compared with UMC. A total of 107 adults with onset of LBP within the past 12 weeks were randomized to 1 of 3 treatment groups: MTM, MAM, or UMC. Outcome measures included the Oswestry LBP Disability Index (0-100 scale) and numeric pain rating (0-10 scale). Participants in the manipulation groups were treated twice weekly during 4 weeks; subjects in UMC were seen for 3 visits during this time. Outcome measures were captured at baseline, 4 weeks, 3 months, and 6 months. Linear regression showed a statistically significant advantage of MTM at 4 weeks compared with MAM (disability = -8.1, P = 0.009; pain = -1.4, P = 0.002) and UMC (disability = -6.5, P = 0.032; pain = -1.7, P < 0.001). Responder analysis, defined as 30% and 50% reductions in Oswestry LBP Disability Index scores revealed a significantly greater proportion of responders at 4 weeks in MTM (76%; 50%) compared with MAM (50%; 16%) and UMC (48%; 39%). Similar between-group results were found for pain: MTM (94%; 76%); MAM (69%; 47%); and UMC (56%; 41%). No statistically significant group differences were found between MAM and UMC, and for any comparison at 3 or 6 months. MTM provides greater short-term reductions in self-reported disability and pain scores compared with UMC or MAM. 2.

Cortical integrity of the inferior alveolar canal as a predictor of paresthesia after third-molar extraction.

PubMed

Park, Wonse; Choi, Ji-Wook; Kim, Jae-Young; Kim, Bong-Chul; Kim, Hyung Jun; Lee, Sang-Hwy

2010-03-01

Paresthesia is a well-known complication of extraction of mandibular third molars (MTMs). The authors evaluated the relationship between paresthesia after MTM extraction and the cortical integrity of the inferior alveolar canal (IAC) by using computed tomography (CT). The authors designed a retrospective cohort study involving participants considered, on the basis of panoramic imaging, to be at high risk of experiencing injury of the inferior alveolar nerve who subsequently underwent CT imaging and extraction of the MTMs. The primary predictor variable was the contact relationship between the IAC and the MTM as viewed on a CT image, classified into three groups: group 1, no contact; group 2, contact between the MTM and the intact IAC cortex; group 3, contact between the MTM and the interrupted IAC cortex. The secondary predictor variable was the number of CT image slices showing the cortical interruption around the MTM. The outcome variable was the presence or absence of postoperative paresthesia after MTM extraction. The study sample comprised 179 participants who underwent MTM extraction (a total of 259 MTMs). Their mean age was 23.6 years, and 85 (47.5 percent) were male. The overall prevalence of paresthesia was 4.2 percent (11 of 259 teeth). The prevalence of paresthesia in group 3 (involving an interrupted IAC cortex) was 11.8 percent (10 of 85 cases), while for group 2 (involving an intact IAC cortex) and group 1 (involving no contact) it was 1.0 percent (1 of 98 cases) and 0.0 percent (no cases), respectively. The frequency of nerve damage increased with the number of CT image slices showing loss of cortical integrity (P=.043). The results of this study indicate that loss of IAC cortical integrity is associated with an increased risk of experiencing paresthesia after MTM extraction.

Differential Muscle Hypertrophy Is Associated with Satellite Cell Numbers and Akt Pathway Activation Following Activin Type IIB Receptor Inhibition in Mtm1 p.R69C Mice

PubMed Central

Lawlor, Michael W.; Viola, Marissa G.; Meng, Hui; Edelstein, Rachel V.; Liu, Fujun; Yan, Ke; Luna, Elizabeth J.; Lerch-Gaggl, Alexandra; Hoffmann, Raymond G.; Pierson, Christopher R.; Buj-Bello, Anna; Lachey, Jennifer L.; Pearsall, Scott; Yang, Lin; Hillard, Cecilia J.; Beggs, Alan H.

2015-01-01

X-linked myotubular myopathy is a congenital myopathy caused by deficiency of myotubularin. Patients often present with severe perinatal weakness, requiring mechanical ventilation to prevent death from respiratory failure. We recently reported that an activin receptor type IIB inhibitor produced hypertrophy of type 2b myofibers and modest increases of strength and life span in the severely myopathic Mtm1δ4 mouse model of X-linked myotubular myopathy. We have now performed a similar study in the less severely symptomatic Mtm1 p.R69C mouse in hopes of finding greater treatment efficacy. Activin receptor type IIB inhibitor treatment of Mtm1 p.R69C animals produced behavioral and histological evidence of hypertrophy in gastrocnemius muscles but not in quadriceps or triceps. The ability of the muscles to respond to activin receptor type IIB inhibitor treatment correlated with treatment-induced increases in satellite cell number and several muscle-specific abnormalities of hypertrophic signaling. Treatment-responsive Mtm1 p.R69C gastrocnemius muscles displayed lower levels of phosphorylated ribosomal protein S6 and higher levels of phosphorylated eukaryotic elongation factor 2 kinase than were observed in Mtm1 p.R69C quadriceps muscle or in muscles from wild-type littermates. Hypertrophy in the Mtm1 p.R69C gastrocnemius muscle was associated with increased levels of phosphorylated ribosomal protein S6. Our findings indicate that muscle-, fiber type-, and mutation-specific factors affect the response to hypertrophic therapies that will be important to assess in future therapeutic trials. PMID:24726641

The BepiColombo Spacecraft: The Mercury Transfer Module Structure Qualification Test Campaign Description

NASA Astrophysics Data System (ADS)

Martin Zurdo, M. J.

2012-07-01

The BepiColombo is a space mission to Mercury (ESA in cooperation with Japan Aerospace Exploration Agency). The spacecraft consist of three different structures: two orbiters responsible for the scientific mission (MPO and MMO) and one service module, Mercury Transfer Module (MTM), which provides propulsion and services during the journey to Mercury. Taking into account only the MTM structure, the companies involved are ASTRIUM GERMANY acting as the prime contractor and ASTRIUM UK acting as the co- prime contractor company. EADS CASA Espacio (ECE) in Spain is the company responsible for the final design, manufacturing and qualification of the MTM structure. The test campaign specimen is the MTM core structure, which corresponds to the central cone with the structure floors, shear panels and tank support structure. This test campaign qualifies the primary load path and its primary interfaces; the rest of the MTM structure is qualified by system level vibration test. In order to qualify the MTM structure, three different kinds of qualification tests have been performed: stiffness test, global strength test and local tests in different specific areas. The most relevant test during the campaign is the global strength test case, in which several external loads are introduced (different interfaces) simulating the load introduction for a selected critical flight case. There are two important items in the qualification test campaign: 1. The instrumentation of the structure, with two main functions: to control the specimen under test loads, and to demonstrate the qualification of the structure. 2. The set-up structure, designed by ECE to allow the correct load introduction on each testing case during the whole test campaign. This paper describes the MTM structure test campaign from the definition of the loads applied in each test to the qualification of the complete structure.

Myotubular Myopathy in a girl with a deletion of Xq27-q28 and unbalanced X inactivation assigns the MTM1 gene to a 600-kb region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dahl, N.; Mandel, J.L.; Chery, M.

1995-05-01

A young girl with a clinically moderate form of myotubular myopathy was found to carry a cytogenetically detectable deletion in Xq27-q28. The deletion had occurred de novo on the paternal X chromosome. It encompasses the fragile X (FRAXA) and Hunter syndrome (IDS) loci, and the DXS304 and DXS455 markers, in Xq27.3 and proximal Xq28. Other loci from the proximal half of Xq28 (DXS49, DXS256, DXS258, DXS305, and DXS497) were found intact. As the X-linked myotubular myopathy locus (MTM1) was previously mapped to Xq28 by linkage analysis, the present observation suggested that MTM1 is included in the deletion. However, a significantmore » clinical phenotype is unexpected in a female MTM1 carrier. Analysis of inactive X-specific methylation at the androgen receptor gene showed that the deleted X chromosome was active in {approximately}80% of leukocytes. Such unbalanced inactivation may account for the moderate MTM1 phenotype and for the mental retardation that later developed in the patient. This observation is discussed in relation to the hypothesis that a locus modulating X inactivation may lie in the region. Comparison of this deletion with that carried by a male patient with a severe Hunter syndrome phenotype but no myotubular myopathy, in light of recent linkage data on recombinant MTM1 families, led to a considerable refinement of the position of the MTM1 locus, to a region of {approximately}600 kb, between DXS304 and DXS497. 46 refs., 4 figs.« less

Differential muscle hypertrophy is associated with satellite cell numbers and Akt pathway activation following activin type IIB receptor inhibition in Mtm1 p.R69C mice.

PubMed

Lawlor, Michael W; Viola, Marissa G; Meng, Hui; Edelstein, Rachel V; Liu, Fujun; Yan, Ke; Luna, Elizabeth J; Lerch-Gaggl, Alexandra; Hoffmann, Raymond G; Pierson, Christopher R; Buj-Bello, Anna; Lachey, Jennifer L; Pearsall, Scott; Yang, Lin; Hillard, Cecilia J; Beggs, Alan H

2014-06-01

X-linked myotubular myopathy is a congenital myopathy caused by deficiency of myotubularin. Patients often present with severe perinatal weakness, requiring mechanical ventilation to prevent death from respiratory failure. We recently reported that an activin receptor type IIB inhibitor produced hypertrophy of type 2b myofibers and modest increases of strength and life span in the severely myopathic Mtm1δ4 mouse model of X-linked myotubular myopathy. We have now performed a similar study in the less severely symptomatic Mtm1 p.R69C mouse in hopes of finding greater treatment efficacy. Activin receptor type IIB inhibitor treatment of Mtm1 p.R69C animals produced behavioral and histological evidence of hypertrophy in gastrocnemius muscles but not in quadriceps or triceps. The ability of the muscles to respond to activin receptor type IIB inhibitor treatment correlated with treatment-induced increases in satellite cell number and several muscle-specific abnormalities of hypertrophic signaling. Treatment-responsive Mtm1 p.R69C gastrocnemius muscles displayed lower levels of phosphorylated ribosomal protein S6 and higher levels of phosphorylated eukaryotic elongation factor 2 kinase than were observed in Mtm1 p.R69C quadriceps muscle or in muscles from wild-type littermates. Hypertrophy in the Mtm1 p.R69C gastrocnemius muscle was associated with increased levels of phosphorylated ribosomal protein S6. Our findings indicate that muscle-, fiber type-, and mutation-specific factors affect the response to hypertrophic therapies that will be important to assess in future therapeutic trials. Copyright © 2014 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Community pharmacy-based medication therapy management services: financial impact for patients.

PubMed

Dodson, Sarah E; Ruisinger, Janelle F; Howard, Patricia A; Hare, Sarah E; Barnes, Brian J

2012-07-01

To determine the direct financial impact for patients resulting from Medication Therapy Management (MTM) interventions made by community pharmacists. Secondary objectives include evaluating the patient and physician acceptance rates of the community pharmacists' recommended MTM interventions. This was a retrospective observational study conducted at 20 Price Chopper and Hen House grocery store chain pharmacies in the Kansas City metro area from January 1, 2010 to December 31, 2010. Study patients were Medicare Part D beneficiaries eligible for MTM services. The primary outcome was the change in patient out-of-pocket prescription medication expense as a result of MTM services. Of 128 patients included in this study, 68% experienced no out-of-pocket financial impact on their medication expenses as a result of MTM services. A total of 27% of the patients realized a cost-savings (USD440.50 per year, (SD=289.69)) while another 5% of patients saw a cost increase in out-of-pocket expense (USD255.66 per year, (SD=324.48)). The net financial impact for all 128 patients who participated in MTM services was an average savings of USD102.83 per patient per year (SD=269.18, p<0.0001). Pharmacists attempted a total of 732 recommendations; 391 (53%) were accepted by both the patient and their prescriber. A total of 341 (47%) recommendations were not accepted because of patient refusal (290, 85%) or prescriber refusal (51, 15%). Patient participation in MTM services reduces patient out-of-pocket medication expense. However, this savings is driven by only 32% of subjects who are experiencing a financial impact on out-of-pocket medication expense. Additionally, the majority of the pharmacists' recommended interventions (53%) were accepted by patients and prescribers.

Retrospective financial analysis of medication therapy management services from the pharmacy's perspective.

PubMed

McDonough, Randal P; Harthan, Aaron A; McLeese, Kelly E; Doucette, William R

2010-01-01

To determine the net financial gain or loss for medication therapy management (MTM) services provided to patients by an independent community pharmacy during 16 months of operation. Retrospective study. Independent community pharmacy in Iowa City, IA, from September 1, 2006, to December 31, 2007. Patients receiving MTM services during the specified period who had proper documentation of reimbursement for the services. MTM services were provided to the patient and documented by the pharmacist or student pharmacist. Net financial gains or losses for providing MTM services. Sensitivity analyses included costs that might be incurred under various conditions of operation. 103 initial and 88 follow-up MTM visits were conducted during a 16-month time period. The total cost for these services to the pharmacy was $11,191.72. Total revenue from these services was $11,195.00; therefore, the pharmacy experienced a net financial gain of $3.28. Sensitivity analyses were conducted, revealing the net gain/loss to the pharmacy if a student pharmacist was used and the net gain/loss if the pharmacist needed extra training to provide the services. Using a student pharmacist resulted in a net gain of $6,308.48, while extra training for the pharmacist resulted in a net loss of $1,602.72. The MTM service programs showed a positive financial gain after 16 months of operation, which should encourage pharmacists to incorporate these services into their practice.

TBM/MTM for HTS-FNSF: An innovative testing strategy to qualify/validate fusion technologies for U.S. DEMO

DOE PAGES

El-Guebaly, Laila; Rowcliffe, Arthur; Menard, Jonathan; ...

2016-08-11

The qualification and validation of nuclear technologies are daunting tasks for fusion demonstration (DEMO) and power plants. This is particularly true for advanced designs that involve harsh radiation environment with 14 MeV neutrons and high-temperature operating regimes. This paper outlines the unique qualification and validation processes developed in the U.S., offering the only access to the complete fusion environment, focusing on the most prominent U.S. blanket concept (the dual cooled PbLi (DCLL)) along with testing new generations of structural and functional materials in dedicated test modules. The venue for such activities is the proposed Fusion Nuclear Science Facility (FNSF), whichmore » is viewed as an essential element of the U.S. fusion roadmap. A staged blanket testing strategy has been developed to test and enhance the DCLL blanket performance during each phase of FNSF D-T operation. A materials testing module (MTM) is critically important to include in the FNSF as well to test a broad range of specimens of future, more advanced generations of materials in a relevant fusion environment. Here, the most important attributes for MTM are the relevant He/dpa ratio (10–15) and the much larger specimen volumes compared to the 10–500 mL range available in the International Fusion Materials Irradiation Facility (IFMIF) and European DEMO-Oriented Neutron Source (DONES).« less

Movement-to-music computer technology: a developmental play experience for children with severe physical disabilities.

PubMed

Tam, Cynthia; Schwellnus, Heidi; Eaton, Ceilidh; Hamdani, Yani; Lamont, Andrea; Chau, Tom

2007-01-01

Children with severe physical disabilities often lack the physical skills to explore their environment independently, and to play with toys or musical instruments. The movement-to-music (MTM) system is an affordable computer system that allows children with limited movements to play and create music. The present study explored parents' experiences of using the MTM system with their children. A qualitative methodology employing in-depth interview techniques was used with six mothers and their children. The themes extracted from the data were organized under two main concepts of the International Classification of Functioning, Disability, and Health (ICF) (WHO, 2001) framework. The results showed that the MTM expanded horizons for the child along the ICF health dimensions and the MTM had a positive impact on ICF environmental determinants of health. The small sample size should be noted as a limitation of this study. Further research should be carried out with a larger sample of children with restricted mobility to obtain a better understanding of the impact of MTM technology on children's psychosocial development.

Using pharmacists to improve risk stratification and management of stage 3A chronic kidney disease: a feasibility study.

PubMed

Chang, Alex R; Evans, Michael; Yule, Christina; Bohn, Larissa; Young, Amanda; Lewis, Meredith; Graboski, Elisabeth; Gerdy, Bethany; Ehmann, William; Brady, Jonathan; Lawrence, Leah; Antunes, Natacha; Green, Jamie; Snyder, Susan; Kirchner, H Lester; Grams, Morgan; Perkins, Robert

2016-11-08

Measurement of albuminuria to stratify risk in chronic kidney disease (CKD) is not done universally in the primary care setting despite recommendation in KDIGO (Kidney Disease Improving Global Outcomes) guidelines. Pharmacist medication therapy management (MTM) may be helpful in improving CKD risk stratification and management. We conducted a pragmatic, cluster-randomized trial using seven primary care clinic sites in the Geisinger Health System to evaluate the feasibility of pharmacist MTM in patients with estimated glomerular filtration rate (eGFR) 45-59 ml/min/1.73 m 2 and uncontrolled blood pressure (≥150/85 mmHg). In the three pharmacist MTM sites, pharmacists were instructed to follow a protocol aimed to improve adherence to KDIGO guidelines on testing for proteinuria and lipids, and statin and blood pressure medical therapy. In the four control clinics, patients received usual care. The primary outcome was proteinuria screening over a follow-up of 1 year. A telephone survey was administered to physicians, pharmacists, and patients in the pharmacist MTM arm at the end of the trial. Baseline characteristics were similar between pharmacist MTM (n = 24) and control (n = 23) patients, although pharmacist MTM patients tended to be younger (64 vs. 71 y; p = 0.06) and less likely to have diabetes (17 % vs. 35 %; p = 0.2) or baseline proteinuria screening (41.7 % vs. 60.9 %, p = 0.2). Mean eGFR was 54 ml/min/1.73 m 2 in both groups. The pharmacist MTM intervention did not significantly improve total proteinuria screening at the population level (OR 2.6, 95 % CI: 0.5-14.0; p = 0.3). However, it tended to increase screening of previously unscreened patients (78.6 % in the pharmacist MTM group compared to 33.3 % in the control group; OR 7.3, 95 % CI: 0.96-56.3; p = 0.05). In general, the intervention was well-received by patients, pharmacists, and providers, who agreed that pharmacists could play an important role in CKD management. A few patients contacted the research team to express anxiety about having a CKD diagnosis without prior knowledge. Pharmacist MTM may be useful in improving risk stratification and management of CKD in the primary care setting, although implementation requires ongoing education and multidisciplinary collaboration and careful communication regarding CKD diagnosis. Future studies are needed to establish the effectiveness of pharmacist MTM on slowing CKD progression and improvement in cardiovascular outcomes. ClinicalTrials.gov, NCT02208674 Registered August 1, 2014, first patient enrolled September 30, 2014.

Effect of an Advanced Pharmacy Practice Experience on Medication Therapy Management Services in a Centralized Retail Pharmacy Program.

PubMed

Vande Griend, Joseph P; Rodgers, Melissa; Nuffer, Wesley

2017-05-01

Medication therapy management (MTM) delivery is increasingly important in managed care. Successful delivery positively affects patient health and improves Centers for Medicare & Medicaid Services star ratings, a measure of health plan quality. As MTM services continue to grow, there is an increased need for efficient and effective care models. The primary objectives of this project were to describe the delivery of MTM services by fourth-year Advanced Pharmacy Practice Experience (APPE) students in a centralized retail pharmacy system and to evaluate and quantify the clinical and financial contributions of the students. The secondary objective was to describe the engagement needed to complete comprehensive medication reviews (CMRs) and targeted interventions. From May 2015 to December 2015, thirty-five APPE students from the University of Colorado Skaggs School of Pharmacy provided MTM services at Albertsons Companies using the OutcomesMTM and Mirixa platforms. Students delivered patient care services by phone at the central office and provided face-to-face visits at pharmacies in the region. With implementation of the MTM APPE in 2015, the team consisted of 2 MTM pharmacists and pharmacy students, as compared with 1 MTM pharmacist in 2014. The number of CMRs and targeted interventions completed and the estimated additional revenue generated during the 2015 time period were compared with those completed from May through December 2014. The patient and provider engagement needed to complete the CMRs and targeted interventions was summarized. 125 CMRs and 1,918 targeted interventions were billed in 2015, compared with 13 CMRs and 767 targeted interventions in 2014. An estimated $16,575-$49,272 of additional revenue was generated in 2015. To complete the interventions in 2015, the team engaged in 1,714 CMR opportunities and 4,686 targeted intervention opportunities. In this MTM rotation, students provided real-life care to patients, resulting in financial and clinical contributions. This model of education and care delivery can be replicated in the community pharmacy or managed care setting. APPE students are an important component of this model of care delivery, particularly when considering the level of patient engagement needed to complete MTM interventions. No outside funding supported this research. The authors have no conflicts of interest to disclose related to this work. All authors contributed to study concept and design. Rodgers collected the data, and data interpretation was performed by Vande Griend, along with Rodgers and Nuffer. The manuscript was written and revised primarily by Vande Griend, along with Nuffer and Rodgers. This project was presented at the Pharmacy Quality Alliance Annual Meeting in Arlington, Virginia, in May 2016.

46 CFR Table I to Part 150 - Alphabetical List of Cargoes

Code of Federal Regulations, 2014 CFR

2014-10-01

... (C17+) alkanoic acid 34 CUS CFT Corn syrup 43 CSY Cottonseed oil, fatty acid 34 CFY Creosote 21 2 CCT... tar 33 COR OCT Coal tar distillate 33 CDL Coal tar, high temperature 33 CHH Coal tar pitch 33 CTP... MTM Formaldehyde solution 19 2 FMS Formamide 10 FAM Formic acid 4 2 FMA Fructose solution 43 Fumaric...

46 CFR Table I to Part 150 - Alphabetical List of Cargoes

Code of Federal Regulations, 2013 CFR

2013-10-01

... (C17+) alkanoic acid 34 CUS CFT Corn syrup 43 CSY Cottonseed oil, fatty acid 34 CFY Creosote 21 2 CCT... tar 33 COR OCT Coal tar distillate 33 CDL Coal tar, high temperature 33 CHH Coal tar pitch 33 CTP... MTM Formaldehyde solution 19 2 FMS Formamide 10 FAM Formic acid 4 2 FMA Fructose solution 43 Fumaric...

46 CFR Table I to Part 150 - Alphabetical List of Cargoes

Code of Federal Regulations, 2010 CFR

2010-10-01

... (C17+) alkanoic acid 34 CUS CFT Corn syrup 43 CSY Cottonseed oil, fatty acid 34 CFY Creosote 21 2 CCT... tar 33 COR OCT Coal tar distillate 33 CDL Coal tar, high temperature 33 CHH Coal tar pitch 33 CTP... MTM Formaldehyde solution 19 2 FMS Formamide 10 FAM Formic acid 4 2 FMA Fructose solution 43 Fumaric...

46 CFR Table I to Part 150 - Alphabetical List of Cargoes

Code of Federal Regulations, 2011 CFR

2011-10-01

... (C17+) alkanoic acid 34 CUS CFT Corn syrup 43 CSY Cottonseed oil, fatty acid 34 CFY Creosote 21 2 CCT... tar 33 COR OCT Coal tar distillate 33 CDL Coal tar, high temperature 33 CHH Coal tar pitch 33 CTP... MTM Formaldehyde solution 19 2 FMS Formamide 10 FAM Formic acid 4 2 FMA Fructose solution 43 Fumaric...

46 CFR Table I to Part 150 - Alphabetical List of Cargoes

Code of Federal Regulations, 2012 CFR

2012-10-01

... (C17+) alkanoic acid 34 CUS CFT Corn syrup 43 CSY Cottonseed oil, fatty acid 34 CFY Creosote 21 2 CCT... tar 33 COR OCT Coal tar distillate 33 CDL Coal tar, high temperature 33 CHH Coal tar pitch 33 CTP... MTM Formaldehyde solution 19 2 FMS Formamide 10 FAM Formic acid 4 2 FMA Fructose solution 43 Fumaric...

Minnesota Department of Human Services audit of medication therapy management programs.

PubMed

Smith, Stephanie; Cell, Penny; Anderson, Lowell; Larson, Tom

2013-01-01

To inform medication therapy management (MTM) providers of findings of the Minnesota Department of Human Services review of claims submitted to Minnesota Health Care Programs (MHCP) for patients receiving MTM services and to discuss the impact of the audit on widespread MTM services and future audits. A retrospective review was completed on MTM claims submitted to MHCP from 2008 to 2010. The auditor verified that the Current Procedural Terminology codes billed matched the actual number of medications, conditions, and drug therapy problems assessed during an encounter. 190 claims were reviewed for 57 distinct pharmacies that billed for MTM services from 2008 to 2010, representing 4.5% of all claims submitted. The auditor reported that generally, the documentation within the electronic medical record had the least "up-coding" of all documentation systems. A total of 18 claims were coded at a higher level than appropriate, but only 10 notices were sent out to recover money because the others did not meet the minimum $50 threshold. The auditor expressed concerns that a number of claims billed at the highest complexity level were only 15 minutes long. Providers will need to be cautious of the conditions that they bill as complex and of how they define drug therapy problems. Everything for which is being billed must be clearly assessed or rationalized in the documentation note. The auditor expressed that overall, documentation was well done; however, many MTM providers are now asking how to internally prepare for future audits.

Nacre-mimetic clay/xyloglucan bionanocomposites: a chemical modification route for hygromechanical performance at high humidity.

PubMed

Kochumalayil, Joby J; Morimune, Seira; Nishino, Takashi; Ikkala, Olli; Walther, Andreas; Berglund, Lars A

2013-11-11

Nacre-mimetic bionanocomposites of high montmorillonite (MTM) clay content, prepared from hydrocolloidal suspensions, suffer from reduced strength and stiffness at high relative humidity. We address this problem by chemical modification of xyloglucan in (XG)/MTM nacre-mimetic nanocomposites, by subjecting the XG to regioselective periodate oxidation of side chains to enable it to form covalent cross-links to hydroxyl groups in neighboring XG chains or to the MTM surface. The resulting materials are analyzed by FTIR spectroscopy, thermogravimetric analysis, carbohydrate analysis, calorimetry, X-ray diffraction, scanning electron microscopy, tensile tests, and oxygen barrier properties. We compare the resulting mechanical properties at low and high relative humidity. The periodate oxidation leads to a strong increase in modulus and strength of the materials. A modulus of 30 GPa for cross-linked composite at 50% relative humidity compared with 13.7 GPa for neat XG/MTM demonstrates that periodate oxidation of the XG side chains leads to crucially improved stress transfer at the XG/MTM interface, possibly through covalent bond formation. This enhanced interfacial adhesion and internal cross-linking of the matrix moreover preserves the mechanical properties at high humidity condition and leads to a Young's modulus of 21 GPa at 90%RH.

School of pharmacy-based medication therapy management program: development and initial experience.

PubMed

Lam, Annie; Odegard, Peggy Soule; Gardner, Jacqueline

2012-01-01

To describe a school of pharmacy-community pharmacy collaborative model for medication therapy management (MTM) service and training. University of Washington (UW) School of Pharmacy (Seattle), from July to December 2008. MTM services and training. A campus-based MTM pharmacy was established for teaching, practice, and collaboration with community pharmacies to provide comprehensive medication reviews (CMRs) and MTM training. Number of collaborating pharmacies, number of patients contacted, number of CMRs conducted, and estimated cost avoidance (ECA). UW Pharmacy Cares was licensed as a Class A pharmacy (nondispensing) and signed "business associate" agreements with six community pharmacies. During July to December 2008, 10 faculty pharmacists completed training and 5 provided CMR services to 17 patients (5 telephonic and 12 face-to-face interviews). A total of 67 claims (17 CMRs and 50 CMR-generated claims) were submitted for reimbursement of $1,642 ($96.58/CMR case). Total ECA was $54,250, averaging $3,191.19 per patient. Seven student pharmacists gained CMR interview training. Interest in collaboration by community pharmacies was lower than expected; however, the campus-community practice model addressed unmet patient care needs, reduced outstanding MTM CMR case loads, increased ECA, and facilitated faculty development and training of student pharmacists.

HIV medication therapy management services in community pharmacies

PubMed Central

Kauffman, Yardlee; Nair, Vidya; Herist, Keith; Thomas, Vasavi; Weidle, Paul J.

2015-01-01

Objectives To present a rationale and a proposed structure to support pharmacist-delivered medication therapy management (MTM) for human immunodeficiency virus (HIV) disease and to outline challenges to implementing and sustaining the service. Data sources Professional literature. Summary Historically, the effect of pharmacy services for HIV-infected persons has been demonstrated in inpatient and clinic-based settings. Developing similar programs adapted for community pharmacists could be a model of care to improve patient adherence to antiretroviral therapy and retention in care. Initiation of antiretroviral therapy and regular monitoring of CD4+ cell count, HIV RNA viral load, adverse drug events, and adherence form the backbone of successful medical management of HIV infection. Support for these services can be provided to HIV-infected patients through pharmacist-managed HIV MTM programs in community pharmacy settings in collaboration with primary providers and other health care professionals. Conclusion Community pharmacists can help meet the growing need for HIV care through provision of MTM services. Although resources have been developed, including the general MTM framework, challenges of adequate training, education, and support of community pharmacists need to be addressed in order for HIV MTM to be a successful model. PMID:23229993

Integrating home-based medication therapy management (MTM) services in a health system.

PubMed

Reidt, Shannon; Holtan, Haley; Stender, Jennifer; Salvatore, Toni; Thompson, Bruce

2016-01-01

To describe the integration of home-based Medication Therapy Management (MTM) into the ambulatory care infrastructure of a large urban health system and to discuss the outcomes of this service. Minnesota from September 2012 to December 2013. The health system has more than 50 primary care and specialty clinics. Eighteen credentialed MTM pharmacists are located in 16 different primary care and specialty settings, with the greatest number of pharmacists providing services in the internal medicine clinic. Home-based MTM was promoted throughout the clinics within the health system. Physicians, advanced practice providers, nurses, and pharmacists could refer patients to receive MTM in their homes. A home visit had the components of a clinic-based visit and was documented in the electronic health record (EHR); however, providing the service in the home allowed for a more direct assessment of environmental factors affecting medication use. Number of home MTM referrals, reason for referral and type of referring provider, number and type of medication-related problems (MRPs). In the first 15 months, 74 home visits were provided to 53 patients. Sixty-six percent of the patients were referred from the Internal Medicine Clinic. Referrals were also received from the senior care, coordinated care, and psychiatry clinics. Approximately 50% of referrals were made by physicians. More referrals (23%) were made by pharmacists compared with advanced practice providers, who made 21% of referrals. The top 3 reasons for referral were: nonadherence, transportation barriers, and the need for medication reconciliation with a home care nurse. Patients had a median of 3 MRPs with the most common (40%) MRP related to compliance. Home-based MTM is feasibly delivered within the ambulatory care infrastructure of a health system with sufficient provider engagement as demonstrated by referrals to the service. Copyright © 2016 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Native and microwave-modified Terminalia mantaly gums as sustained-release and bioadhesive excipients in naproxen matrix tablet formulations.

PubMed

Odeniyi, Michael Ayodele; Oyedokun, Babatunde Mukhtar; Bamiro, Oluyemisi Adebowale

2017-01-01

Hydrophilic polymers provide a means of sustaining drug delivery. Native gums may be limited in function, but modification may improve their activity. The aim of the study was to evaluate native and modified forms of Terminalia mantaly gum for their sustained-release and bioadhesive properties. The native gum (NTM) was modified by microwave irradiation for 20 seconds (MTM20) and 60 seconds (MTM60) and characterized using microscopy, Fourier transform infrared spectroscopy (FTIR) and packing properties. The effects of the thermally induced molecular reorientation were determined. Tablet formulations of naproxen were produced by direct compression. The mechanical, bioadhesive and release properties of the formulations were determined. Irradiation of NTM improved the gum's flow properties, resulting in Carr's Index and Hausner's ratios lower than 16% and 1.25, respectively. Swelling studies showed that MTM20 and MTM60 had lower water absorption capacity and swelling index values, while packing properties improved upon irradiation, as depicted by lower tapped density values. FTIR spectra of samples showed that the irradiated gums were distinct from the native gums and did not interact with naproxen sodium. The gum's mechanical properties improved with MTM20 and MTM60 and sustained-release action of up 12 h was obtained. Inclusion of hydroxypropyl methylcellulose (HPMC) in the tablet formulations proved critical for bioadhesion. Microwave irradiation of native Terminalia mantaly gum improved the flow, mechanical and sustained-release properties of Naproxen tablets, and the addition of HPMC increased bioadhesion properties. The tablet properties of the native gum were significantly improved after 20 s of microwave irradiation.

75 FR 438 - Notice of Invitation-Coal Exploration License Application MTM 99242

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-05

...] Notice of Invitation--Coal Exploration License Application MTM 99242 AGENCY: Bureau of Land Management... Energy Company in a program for the exploration of coal deposits owned by the United States of America in... section [[Page 439

Applying a new theory to smoking cessation: case of multi-theory model (MTM) for health behavior change.

PubMed

Sharma, Manoj; Khubchandani, Jagdish; Nahar, Vinayak K

2017-01-01

Background: Smoking continues to be a public health problem worldwide. Smoking and tobacco use are associated with cardiovascular diseases that include coronary heart disease, atherosclerosis, cerebrovascular disease, and abdominal aortic aneurysm. Programs for quitting smoking have played a significant role in reduction of smoking in the United States. The smoking cessation interventions include counseling, nicotine replacement therapy, buproprion therapy, and varenicline therapy. The success rates with each of these approaches vary with clear need for improvement. Moreover, there is a need for a robust theory that can guide smoking cessation counseling interventions and increase the success rates. A fourth generation approach using multi-theory model (MTM) of health behavior change is introduced in this article for smoking cessation. An approach for developing and evaluating an intervention for smoking cessation is presented along with a measurement tool. Methods: A literature review reifying the MTM of health behavior change for smoking cessation has been presented. An instrument designed to measure constructs of MTM and associated smoking cessation behavior has been developed. Results: The instrument developed is available for validation, reliability and prediction study pertaining to smoking cessation. The intervention is available for testing in a randomized control trial involving smokers. Conclusion: MTM is a robust theory that holds promise for testing and application to smoking cessation.

Long-term effects of systemic gene therapy in a canine model of myotubular myopathy.

PubMed

Elverman, Matthew; Goddard, Melissa A; Mack, David; Snyder, Jessica M; Lawlor, Michael W; Meng, Hui; Beggs, Alan H; Buj-Bello, Ana; Poulard, Karine; Marsh, Anthony P; Grange, Robert W; Kelly, Valerie E; Childers, Martin K

2017-11-01

X-linked myotubular myopathy (XLMTM), a devastating pediatric disease caused by the absence of the protein myotubularin, results from mutations in the MTM1 gene. While there is no cure for XLMTM, we previously reported effects of MTM1 gene therapy using adeno-associated virus (AAV) vector on muscle weakness and pathology in MTM1-mutant dogs. Here, we followed 2 AAV-infused dogs over 4 years. We evaluated gait, strength, respiration, neurological function, muscle pathology, AAV vector copy number (VCN), and transgene expression. Four years following AAV-mediated gene therapy, gait, respiratory performance, neurological function and pathology in AAV-infused XLMTM dogs remained comparable to their healthy littermate controls despite a decline in VCN and muscle strength. AAV-mediated gene transfer of MTM1 in young XLMTM dogs results in long-term expression of myotubularin transgene with normal muscular performance and neurological function in the absence of muscle pathology. These findings support a clinical trial in patients. Muscle Nerve 56: 943-953, 2017. © 2017 Wiley Periodicals, Inc.

Challenges to Integrating Pharmacogenetic Testing into Medication Therapy Management

PubMed Central

Allen LaPointe, Nancy M.; Moaddeb, Jivan

2015-01-01

Background Some have proposed the integration of pharmacogenetic (PGx) testing into medication therapy management (MTM) to enable further refinement of treatment(s) to reduce risk of adverse responses and improve efficacy. PGx testing involves the analysis of genetic variants associated with therapeutic or adverse response and may be useful in enhancing the ability to identify ineffective and/or harmful drugs or drug combinations. This “enhanced” MTM might also reduce patient concerns about side effects and increase confidence that the medication is effective, addressing two key factors that impact patient adherence - concern and necessity. However, the feasibility and effectiveness of the integration of PGx testing into MTM in clinical practice has not yet been determined. Objectives In this paper, we consider some of the challenges to the integration and delivery of PGx testing in MTM services. What is already known about this subject While the addition of pharmacogenetic testing has been suggested, little literature exists exploring the challenges or feasibility of doing so. PMID:25803768

Multi-Objective Optimization of Fleet-Level Metrics to Determine New System Design Requirements: An Application to Military Air Cargo Fuel Efficiency

DTIC Science & Technology

2014-04-30

15, 2014 11:15 a.m. – 12: 45 p.m. Chair: Ken Mitchell Jr., Director, Research and Analysis, Defense Logistics Agency Mixture Distributions for...póåÉêÖó=Ñçê=fåÑçêãÉÇ=`Ü~åÖÉ= = - 276 - DOC = direct operating cost MTM /D = million ton-miles per day Op,i = indicates if airport i is the initial...highest level of modeled strategic airlift demand, required 32.7 million ton-miles per day ( MTM /D). MTM /D values for each type of aircraft are

Removal of carbamates and detoxification potential in a biomixture: Fungal bioaugmentation versus traditional use.

PubMed

Rodríguez-Rodríguez, Carlos E; Madrigal-León, Karina; Masís-Mora, Mario; Pérez-Villanueva, Marta; Chin-Pampillo, Juan Salvador

2017-01-01

The use of fungal bioaugmentation represents a promising way to improve the performance of biomixtures for the elimination of pesticides. The ligninolyitc fungus Trametes versicolor was employed for the removal of three carbamates (aldicarb, ALD; methomyl, MTM; and methiocarb, MTC) in defined liquid medium; in this matrix ALD and MTM showed similar half-lives (14d), nonetheless MTC exhibited a faster removal, with a half-life of 6.5d. Then the fungus was employed in the bioaugmentation of an optimized biomixture to remove the aforementioned carbamates plus carbofuran (CFN). Bioaugmented and non-bioaugmented systems removed over 99% ALD and MTM after 8d of treatment, nonetheless a slight initial delay in the removal was observed in the bioaugmented biomixtures (removal after 3d: ALD 87%/97%; MTM 86%/99%, in bioaugmented/non-bioaugmented systems). The elimination of the other carbamates was slower, but independent of the presence of the fungus: >98% for MTM after 35d and >99.5% for CFN after 22d. Though the bioaugmentation did not improve the removal capacity of the biomixture, it favored a lower production of transformation products at the first stages of the treatment, and in both cases, a marked decrease in the toxicity of the matrix was swiftly achieved along the process (from 435 to 448 TU to values <1TU in 16d). Copyright © 2016 Elsevier Inc. All rights reserved.

Impact of passive and active promotional strategies on patient acceptance of medication therapy management services.

PubMed

Huet, Alison L; Frail, Caitlin K; Lake, Leslie M; Snyder, Margie E

2015-01-01

To assess the impact of passive and active promotional strategies on patient acceptance of medication therapy management (MTM) services, and to identify reasons for patient acceptance or refusal. Four promotional approaches were developed to offer MTM services to eligible patients, including letters and bag stuffers ("passive" approaches), and face-to-face offers and telephone calls ("active" approaches). Thirty pharmacies in a grocery store chain were randomized to one of the four approaches. Patient acceptance rates were compared among the four groups, and between active and passive approaches using hierarchical logistic regression techniques. Depending on their decision to accept or decline the service, patients were invited to take part in one of two brief telephone surveys. No significant differences were identified among the four promotional methods or between active and passive methods in the analyses. Patients' most frequent reasons for accepting MTM services were potential cost savings, review of how the medications were working, the expert opinion of the pharmacist, and education about medications. Patients' most frequent reasons for declining MTM services were that the participant already felt comfortable with their medications and felt their pharmacist provides these services on a regular basis. No significant difference was found among any of the four groups or between active or passive approaches. Further research is warranted to identify strategies for improving patient engagement in MTM services.

EFFECTS OF MOUNTAINTOP MINING/VALLEY FILL (MTM/VF) ON FUNCTIONAL INDICATORS IN APPALACHIAN HEADWATER STREAMS

EPA Science Inventory

The objectives of this poster were 1)to evaluate the impact of MTM/VF on the functional attributes SOD, soil/sediment respiration rate, soil/sediment DEA and dissolved trace gas concentrations across gradients of mining disturbance and hydrolgy and 2)compare these functional attr...

Evaluation of Eligibility Criteria Used to Identify Patients for Medication Therapy Management Services: A Retrospective Cohort Study in a Medicare Advantage Part D Population.

PubMed

Lee, Janet S; Yang, Jianing; Stockl, Karen M; Lew, Heidi; Solow, Brian K

2016-01-01

General eligibility criteria used by the Centers for Medicare & Medicaid Services (CMS) to identify patients for medication therapy management (MTM) services include having multiple chronic conditions, taking multiple Part D drugs, and being likely to incur annual drug costs that exceed a predetermined threshold. The performance of these criteria in identifying patients in greatest need of MTM services is unknown. Although there are numerous possible versions of MTM identification algorithms that satisfy these criteria, there are limited data that evaluate the performance of MTM services using eligibility thresholds representative of those used by the majority of Part D sponsors. To (a) evaluate the performance of the 2013 CMS MTM eligibility criteria thresholds in identifying Medicare Advantage Prescription Drug (MAPD) plan patients with at least 2 drug therapy problems (DTPs) relative to alternative criteria threshold levels and (b) identify additional patient risk factors significantly associated with the number of DTPs for consideration as potential future MTM eligibility criteria. All patients in the Medicare Advantage Part D population who had pharmacy eligibility as of December 31, 2013, were included in this retrospective cohort study. Study outcomes included 7 different types of DTPs: use of high-risk medications in the elderly, gaps in medication therapy, medication nonadherence, drug-drug interactions, duplicate therapy, drug-disease interactions, and brand-to-generic conversion opportunities. DTPs were identified for each member based on 6 months of most recent pharmacy claims data and 14 months of most recent medical claims data. Risk factors examined in this study included patient demographics and prior health care utilization in the most recent 6 months. Descriptive statistics were used to summarize patient characteristics and to evaluate unadjusted relationships between the average number of DTPs identified per patient and each risk factor. Quartile values identified in the study population for number of diseases, number of drugs, and annual spend were used as potential new criteria thresholds, resulting in 27 new MTM criteria combinations. The performance of each eligibility criterion was evaluated using sensitivity, specificity, positive predictive values (PPVs), and negative predictive values (NPVs). Patients identified with at least 2 DTPs were defined as those who would benefit from MTM services and were used as the gold standard. As part of a sensitivity analysis, patients identified with at least 1 DTP were used as the gold standard. Lastly, a multivariable negative binomial regression model was used to evaluate the relationship between each risk factor and the number of identified DTPs per patient while controlling for the patients' number of drugs, number of chronic diseases, and annual drug spend. A total of 2,578,336 patients were included in the study. The sensitivity, specificity, PPV, and NPV of CMS MTM criteria for the 2013 plan year were 15.3%, 95.6%, 51.3%, and 78.8%, respectively. Sensitivity and PPV improved when the drug count threshold increased from 8 to 10, and when the annual drug cost decreased from $3,144 to $2,239 or less. Results were consistent when at least 1 DTP was used as the gold standard. The adjusted rate of DTPs was significantly greater among patients identified with higher drug and disease counts, annual drug spend, and prior ER or outpatient or hospital visits. Patients with higher median household incomes who were male, younger, or white had significantly lower rates of DTPs. The performance of MTM eligibility criteria can be improved by increasing the threshold values for drug count while decreasing the threshold value for annual drug spend. Furthermore, additional risk factors, such as a recent ER or hospital visit, may be considered as potential MTM eligibility criteria.

An investigation of the ionospheric F region near the EIA crest in India using OI 777.4 and 630.0 nm nightglow observations

NASA Astrophysics Data System (ADS)

Parihar, Navin; Radicella, Sandro Maria; Nava, Bruno; Migoya-Orue, Yenca Olivia; Tiwari, Prabhakar; Singh, Rajesh

2018-05-01

Simultaneous observations of OI 777.4 and OI 630.0 nm nightglow emissions were carried at a low-latitude station, Allahabad (25.5° N, 81.9° E; geomag. lat. ˜ 16.30° N), located near the crest of the Appleton anomaly in India during September-December 2009. This report attempts to study the F region of ionosphere using airglow-derived parameters. Using an empirical approach put forward by Makela et al. (2001), firstly, we propose a novel technique to calibrate OI 777.4 and 630.0 nm emission intensities using Constellation Observing System for Meteorology, Ionosphere, and Climate/Formosa Satellite Mission 3 (COSMIC/FORMOSAT-3) electron density profiles. Next, the electron density maximum (Nm) and its height (hmF2) of the F layer have been derived from the information of two calibrated intensities. Nocturnal variation of Nm showed the signatures of the retreat of the equatorial ionization anomaly (EIA) and the midnight temperature maximum (MTM) phenomenon that are usually observed in the equatorial and low-latitude ionosphere. Signatures of gravity waves with time periods in the range of 0.7-3.0 h were also seen in Nm and hmF2 variations. Sample Nm and hmF2 maps have also been generated to show the usefulness of this technique in studying ionospheric processes.

77 FR 71822 - Notice of Invitation-Coal Exploration License Application MTM 103852, MT

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-04

...] Notice of Invitation--Coal Exploration License Application MTM 103852, MT AGENCY: Bureau of Land... Ambre Energy on a pro rata cost sharing basis in a program for the exploration of coal deposits owned by... program is to gain additional geologic knowledge of the coal underlying the exploration area for the...

Effects of Rosemary Oil (Rosmarinus officinalis) On The Shelf-Life of Minced Rainbow Trout (Oncorhynchus mykiss) during Refrigerated Storage

PubMed Central

Peiretti, Pier Giorgio; Gai, Francesco; Ortoffi, Marco; Aigotti, Riccardo; Medana, Claudio

2012-01-01

The effects of three concentrations (0.2%, 1% and 3%) of rosemary oil (RO) on the freshness indicators, oxidative stability, fatty acid and biogenic amine (BA) contents of minced rainbow trout muscle (MTM) were investigated after different periods of storage (three and nine days) at 4 ± 1 °C. Moreover, the terpene and sesquiterpene contents in the treated MTM were also measured. RO treatment improves the pH, oxidative stability of the lipids and the FA profile, which resulted in a significant extension of MTM shelf-life. Storage time influenced all freshness indicators, with the exception of yellowness and chroma. Treatment with RO had a positive effect, leading to low BA content, especially putrescine, cadaverine, tyramine and histamine. Differences in BA were also found to be due to storage time, with the exception of spermidine, which was not influenced by time. Moreover, the presence of the terpenoid fraction of RO in MTM improved the quality of this ready-to-cook fish food. PMID:28239089

Potential cost savings of medication therapy management in safety-net clinics.

PubMed

Truong, Hoai-An; Groves, C Nicole; Congdon, Heather B; Dang, Diem-Thanh Tanya; Botchway, Rosemary; Thomas, Jennifer

2015-01-01

To evaluate potential cost savings based on estimated cost avoidance from medication therapy management (MTM) services delivered in safety-net clinics over 4 years. High-risk patients taking multiple medications and with chronic conditions were referred for MTM services in primary care safety-net clinics in Maryland from October 1, 2009, to September 30, 2013. Medication-related problems (MRPs) were identified and pharmacists' costs determined to evaluate the estimated cost savings and return on investment (ROI). A range of potential economic outcomes for each MRP identified was assigned to a cost avoidance for outpatient visit, urgent care visit, emergency department visit, and/or hospitalization. Over 4 years, 246 patients received MTM, nearly 2,100 medications were reviewed, and 814 MRPs were identified. The most common MRPs identified were subtherapeutic doses, nonadherence, and untreated indications, with respective prevalences of 38%, 19%, and 16%. The corresponding costs of medical services were estimated at $115,220-$614,570 for all MRPs identified, yielding a mean of $141.55-$755.00 per identified MRP. Pharmacists' expenses for encounters were calculated at a total expenditure of $57,307.50 for 16,965 minutes. ROI based on the time spent during billable face-to-face encounters ranged from 1:5 to 1:25. Pharmacist-provided MTM in safety-net clinics yielded potential economic benefits to the organization. The Primary Care Coalition of Montgomery County plans to expand MTM services to additional clinics to improve patient care and increase cost savings through preventable medical services.

Geologic mapping of Argyre Planitia

NASA Technical Reports Server (NTRS)

Gorsline, Donn S.; Parker, Timothy J.

1995-01-01

This report describes the results from the geologic mapping of the central and southern Argyre basin of Mars. At the Mars Geologic Mapper's Meeting in Flagstaff during July, 1993, Dave Scott (United States Geological Survey, Mars Geologic Mapping Steering Committee Chair) recommended that all four quadrangles be combined into a single 1:1,000,000 scale map for publication. It was agreed that this would be cost-effective and that the decrease in scale would not compromise the original science goals of the mapping. Tim Parker completed mapping on the 1:500,000 scale base maps, for which all the necessary materials had already been produced, and included the work as a chapter in his dissertation, which was completed in the fall of 1994. Geologic mapping of the two southernmost quadrangles (MTM -55036 and MTM -55043; MTM=Mars Transverse Mercator) was completed as planned during the first year of work. These maps and a detailed draft of the map text were given a preliminary review by Dave Scott during summer, 1993. Geologic mapping of the remaining two quadrangles (MTM -50036 and MTM -50043) was completed by summer, 1994. Results were described at the Mars Geologic Mappers Meeting, held in Pocatello, Idaho, during July, 1994. Funds for the third and final year of the project have been transferred to the Jet Propulsion Laboratory, where Tim Parker will revise and finalize all maps and map text for publication by the United States Geological Survey at the 1:1,000,000 map scale.

Are residents of mountain-top mining counties more likely to have infants with birth defects? The West Virginia experience.

PubMed

Lamm, Steven H; Li, Ji; Robbins, Shayhan A; Dissen, Elisabeth; Chen, Rusan; Feinleib, Manning

2015-02-01

Pooled 1996 to 2003 birth certificate data for four central states in Appalachia indicated higher rates of infants with birth defects born to residents of counties with mountain-top mining (MTM) than born to residents of non-mining-counties (Ahern 2011). However, those analyses did not consider sources of uncertainty such as unbalanced distributions or quality of data. Quality issues have been a continuing problem with birth certificate analyses. We used 1990 to 2009 live birth certificate data for West Virginia to reassess this hypothesis. Forty-four hospitals contributed 98% of the MTM-county births and 95% of the non-mining-county births, of which six had more than 1000 births from both MTM and nonmining counties. Adjusted and stratified prevalence rate ratios (PRRs) were computed both by using Poisson regression and Mantel-Haenszel analysis. Unbalanced distribution of hospital births was observed by mining groups. The prevalence rate of infants with reported birth defects, higher in MTM-counties (0.021) than in non-mining-counties (0.015), yielded a significant crude PRR (cPRR = 1.43; 95% confidence interval [CI] = 1.36-1.52) but a nonsignificant hospital-adjusted PRR (adjPRR = 1.08; 95% CI = 0.97-1.20; p = 0.16) for the 44 hospitals. So did the six hospital data analysis ([cPRR = 2.39; 95% CI = 2.15-2.65] and [adjPRR = 1.01; 95% CI, 0.89-1.14; p = 0.87]). No increased risk of birth defects was observed for births from MTM-counties after adjustment for, or stratification by, hospital of birth. These results have consistently demonstrated that the reported association between birth defect rates and MTM coal mining was a consequence of data heterogeneity. The data do not demonstrate evidence of a "Mountain-top Mining" effect on the prevalence of infants with reported birth defects in WV. © 2014 Wiley Periodicals, Inc.

Past, present and perspectives of Manipur traditional medicine: A major health care system available for rural population in the North-East India.

PubMed

Deb, Lokesh; Laishram, Surbala; Khumukcham, Nongalleima; Ningthoukhongjam, Dhaneshwor; Nameirakpam, Surjit Singh; Dey, Amitabha; Moirangthem, Dinesh Singh; Talukdar, Narayan Chandra; Ningthoukhongjam, Tombi Raj

2015-07-01

Traditional health care practices are still being followed extensively in Manipur, North-East India. This is the major or the only medical facility available in some rural areas of Manipur. Cross cultural ethno-pharmacological survey was conducted to document traditional health care practices by Maiba-Maibi (male-female traditional health care practitioners of Manipur). All together 59 traditional practitioners belonging to 12 ethnic communities in nine districts of the Manipur state were interviewed. A predesigned questionnaire was used for interviews, which included queries for type of ailments treating, symptoms, bioresources used, method of preparation, dosage forms, formulation, unit doses. The entire interviews were done in the residence of respective Maiba-Maibi, their patient handing and preparation of medicinal formulations were documented in written and audio-visual format. The survey recorded traditional knowledge on 949 formulations used for 66 human ailments. Five hundred forty six plant products, 42 animal products and 22 organic/inorganic materials were found to be used in these 949 formulations. Five plant species - Zingiber officinale (Zingiberaceae), Cocos nucifera (Arecaceae), Oroxylum indicum (Bignonaceae), Curcuma longa (Zingiberaceae) and Allium sativum (Liliaceae) used by maximum number of Maiba and Maibi in maximum number of formulations. This particular method of documentation keeps traditional knowledge alive. The WHO estimated perspective of traditional medicine across the world. These observations support therapeutic worth of Manipur Traditional medicines (MTM). Having generated a large database in course of this survey, next focus targeted for the scientific justification of MTM with an aim to develop commercially viable products. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

78 FR 76319 - Notice of Invitation-Coal Exploration License Application MTM 106757, Montana

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-17

...] Notice of Invitation--Coal Exploration License Application MTM 106757, Montana AGENCY: Bureau of Land... Signal Peak Energy, LLC on a pro rata cost sharing basis in a program for the exploration of coal... Office coal Web site at http://www.blm.gov/mt/st/en/prog/energy/coal.html . A written notice to...

76 FR 31976 - Notice of Invitation-Coal Exploration License Application MTM 101688

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-02

...] Notice of Invitation--Coal Exploration License Application MTM 101688 AGENCY: Bureau of Land Management... Creek Coal Company on a pro rata cost sharing basis in a program for the exploration of coal deposits... notice to both the Bureau of Land Management (BLM) and the Spring Creek Coal Company as provided in the...

Chronic Cardiovascular Disease Mortality in Mountaintop Mining Areas of Central Appalachian States

ERIC Educational Resources Information Center

Esch, Laura; Hendryx, Michael

2011-01-01

Purpose: To determine if chronic cardiovascular disease (CVD) mortality rates are higher among residents of mountaintop mining (MTM) areas compared to mining and nonmining areas, and to examine the association between greater levels of MTM surface mining and CVD mortality. Methods: Age-adjusted chronic CVD mortality rates from 1999 to 2006 for…

75 FR 62137 - Notice of Public Meeting; Proposed Alluvial Valley Floor Coal Exchange Public Interest Factors...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-07

...; MTM-99236] Notice of Public Meeting; Proposed Alluvial Valley Floor Coal Exchange Public Interest... (SMCRA) of 1977. This exchange (serial number MTM-99236) has been proposed by Jay Nance, Brett A... Director. [FR Doc. 2010-25060 Filed 10-6-10; 8:45 am] BILLING CODE 4310-DN-P ...

Inhibition of Activin Receptor Type IIB Increases Strength and Lifespan in Myotubularin-Deficient Mice

PubMed Central

Lawlor, Michael W.; Read, Benjamin P.; Edelstein, Rachel; Yang, Nicole; Pierson, Christopher R.; Stein, Matthew J.; Wermer-Colan, Ariana; Buj-Bello, Anna; Lachey, Jennifer L.; Seehra, Jasbir S.; Beggs, Alan H.

2011-01-01

X-linked myotubular myopathy (XLMTM) is a congenital disorder caused by deficiency of the lipid phosphatase, myotubularin. Patients with XLMTM often have severe perinatal weakness that requires mechanical ventilation to prevent death from respiratory failure. Muscle biopsy specimens from patients with XLMTM exhibit small myofibers with central nuclei and central aggregations of organelles in many cells. It was postulated that therapeutically increasing muscle fiber size would cause symptomatic improvement in myotubularin deficiency. Recent studies have elucidated an important role for the activin-receptor type IIB (ActRIIB) in regulation of muscle growth and have demonstrated that ActRIIB inhibition results in significant muscle hypertrophy. To evaluate whether promoting muscle hypertrophy can attenuate symptoms resulting from myotubularin deficiency, the effect of ActRIIB-mFC treatment was determined in myotubularin-deficient (Mtm1δ4) mice. Compared with wild-type mice, untreated Mtm1δ4 mice have decreased body weight, skeletal muscle hypotrophy, and reduced survival. Treatment of Mtm1δ4 mice with ActRIIB-mFC produced a 17% extension of lifespan, with transient increases in weight, forelimb grip strength, and myofiber size. Pathologic analysis of Mtm1δ4 mice during treatment revealed that ActRIIB-mFC produced marked hypertrophy restricted to type 2b myofibers, which suggests that oxidative fibers in Mtm1δ4 animals are incapable of a hypertrophic response in this setting. These results support ActRIIB-mFC as an effective treatment for the weakness observed in myotubularin deficiency. PMID:21281811

Attracting Students to Space Science Fields: Mission to Mars

NASA Astrophysics Data System (ADS)

Congdon, Donald R.; Lovegrove, William P.; Samec, Ronald G.

Attracting high school students to space science is one of the main goals of Bob Jones University's annual Mission to Mars (MTM). MTM develops interest in space exploration through a highly realistic simulated trip to Mars. Students study and learn to appreciate the challenges of space travel including propulsion life support medicine planetary astronomy psychology robotics and communication. Broken into teams (Management Spacecraft Design Communications Life Support Navigation Robotics and Science) they address the problems specific to each aspect of the mission. Teams also learn to interact and recognize that a successful mission requires cooperation. Coordinated by the Management Team the students build a spacecraft and associated apparatus connect computers and communications equipment train astronauts on the mission simulator and program a Pathfinder-type robot. On the big day the astronauts enter the spacecraft as Mission Control gets ready to support them through the expected and unexpected of their mission. Aided by teamwork the astronauts must land on Mars perform their scientific mission on a simulated surface of mars and return home. We see the success of MTM not only in successful missions but in the students who come back year after year for another MTM.

Racial and Ethnic Disparities in Meeting MTM Eligibility Criteria Based on Star Ratings Compared with the Medicare Modernization Act.

PubMed

Spivey, Christina A; Wang, Junling; Qiao, Yanru; Shih, Ya-Chen Tina; Wan, Jim Y; Kuhle, Julie; Dagogo-Jack, Samuel; Cushman, William C; Chisholm-Burns, Marie

2018-02-01

Previous research found racial and ethnic disparities in meeting medication therapy management (MTM) eligibility criteria implemented by the Centers for Medicare & Medicaid Services (CMS) in accordance with the Medicare Modernization Act (MMA). To examine whether alternative MTM eligibility criteria based on the CMS Part D star ratings quality evaluation system can reduce racial and ethnic disparities. This study analyzed the Beneficiary Summary File and claims files for Medicare beneficiaries linked to the Area Health Resource File. Three million Medicare beneficiaries with continuous Parts A, B, and D enrollment in 2012-2013 were included. Proposed star ratings criteria included 9 existing medication safety and adherence measures developed mostly by the Pharmacy Quality Alliance. Logistic regression and the Blinder-Oaxaca approach were used to test disparities in meeting MMA and star ratings eligibility criteria across racial and ethnic groups. Multinomial logistic regression was used to examine whether there was a disparity reduction by comparing individuals who were MTM-eligible under MMA but not under star ratings criteria and those who were MTM-eligible under star ratings criteria but not under the MMA. Concerning MMA-based MTM criteria, main and sensitivity analyses were performed to represent the entire range of the MMA eligibility thresholds reported by plans in 2009, 2013, and proposed by CMS in 2015. Regarding star ratings criteria, meeting any 1 of the 9 measures was examined as the main analysis, and various measure combinations were examined as the sensitivity analyses. In the main analysis, adjusted odds ratios for non-Hispanic blacks (backs) and Hispanics to non-Hispanic whites (whites) were 1.394 (95% CI = 1.375-1.414) and 1.197 (95% CI = 1.176-1.218), respectively, under star ratings. Blacks were 39.4% and Hispanics were 19.7% more likely to be MTM-eligible than whites. Blacks and Hispanics were less likely to be MTM-eligible than whites in some sensitivity analyses. Disparities were not completely explained by differences in patient characteristics based on the Blinder-Oaxaca approach. The multinomial logistic regression of each main analysis found significant adjusted relative risk ratios (RRR) between whites and blacks for 2009 (RRR = 0.459, 95% CI = 0.438-0.481); 2013 (RRR = 0.449, 95% CI = 0.434-0.465); and 2015 (RRR = 0.436, 95% CI = 0.425-0.446) and between whites and Hispanics for 2009 (RRR = 0.559, 95% CI = 0.528-0.593); 2013 (RRR = 0.544, 95% CI = 0.521-0.569); and 2015 (RRR = 0.503, 95% CI = 0.488-0.518). These findings indicate a significant reduction in racial and ethnic disparities when using star ratings eligibility criteria; for example, black-white disparities in the likelihood of meeting MTM eligibility criteria were reduced by 55.1% based on star ratings compared with MMA in 2013. Similar patterns were found in most sensitivity and disease-specific analyses. This study found that minorities were more likely than whites to be MTM-eligible under the star ratings criteria. In addition, MTM eligibility criteria based on star ratings would reduce racial and ethnic disparities associated with MMA in the general Medicare population and those with specific chronic conditions. Research reported in this publication was supported by the National Institute on Aging of the National Institutes of Health under award number R01AG049696. The content of this study is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Cushman reports an Eli Lilly grant and uncompensated consulting for Takeda Pharmaceuticals outside this work. The other authors have no potential conflicts of interest to report. Study concept and design were contributed by Wang and Shih, along with Wan, Kuhle, Spivey, and Cushman. Wang, Qiao, and Wan took the lead in data collection, with assistance from the other authors. Data interpretation was performed by Wang, Kuhle, and Qiao, with assistance from the other authors. The manuscript was written by Spivey and Qiao, along with the other authors, and revised by Cushman, Dagogo-Jack, and Chisholm-Burns, along with the other authors.

Design, Fabrication and Testing of Two Dimensional Radio-Frequency Metamaterials

DTIC Science & Technology

2014-03-03

metasurfaces . These antennas are either MTM based or utilize MTMs to increase performance. The benefits of these antennas are: reduced size, lower...reduced size and increased quality factor. Finally, the antennas loaded with metasurfaces are similar to the MTM loading; in the fact that the... metasurface enhances the antenna performance instead of performing the antenna function. This type of antenna has shown increased directionality and

76 FR 28452 - Notice of Proposed Reinstatement of Terminated Oil and Gas Leases MTM 99624 and MTM 99625

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-17

... lease terms for rentals and royalties of $10 per acre and 16\\2/3\\ percent. The lessee paid the $500 administration fee for the reinstatement of each lease and $163 cost for publishing this Notice. The lessee met... increased royalty of 16\\2/3\\ percent; and The $163 cost of publishing this Notice. FOR FURTHER INFORMATION...

76 FR 28452 - Notice of Proposed Reinstatement of Terminated Oil and Gas Lease MTM 94684 and MTM 94685

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-17

... agrees to new lease terms for rentals and royalties of $10 per acre and 16\\2/3\\ percent. The lessee paid the $500 administration fee for the reinstatement of each lease and $163 cost for publishing this... $10 per acre; The increased royalty of 16\\2/3\\ percent; and The $163 cost of publishing this Notice...

Deconstructing the deconstruction of Appalachia: Mountaintop mining effects on hydrology across temporal and spatial scales

NASA Astrophysics Data System (ADS)

Nippgen, F.; Ross, M. R. V.; Bernhardt, E. S.; McGlynn, B. L.

2017-12-01

Mountaintop mining (MTM) is an especially destructive form of surface coal mining. It is widespread in Central Appalachia and is practiced around the world. In the process of accessing coal seams up to several hundred meters below the surface, mountaintops and ridges are removed via explosives and heavy machinery with the resulting overburden pushed into nearby valleys. This broken up rock and soil material represents a largely unknown amount of storage for incoming precipitation that facilitates enhanced chemical weathering rates and increased dissolved solids exports to streams. However, assessing the independent impact of MTM can be difficult in the presence of other forms of mining, especially underground mining. Here, we evaluate the effect of MTM on water quantity and quality on annual, seasonal, and event time scales in two sets of paired watersheds in southwestern West Virginia impacted by MTM. On an annual timescale, the mined watersheds sustained baseflow throughout the year, while the first order watersheds ceased flowing during the latter parts of the growing season. In fractionally mined watersheds that continued to flow, the water in the stream was exclusively generated from mined portions of the watersheds, leading to elevated total dissolved solids in the stream water. On the event time scale, we analyzed 50 storm events over a water year for a range of hydrologic response metrics. The mined watersheds exhibited smaller runoff ratios and longer response times during the wet dormant season, but responded similarly to rainfall events during the growing season or even exceeded the runoff magnitude of the reference watersheds. Our research demonstrates a clear difference in hydrologic response between mined and unmined watersheds during the growing season and the dormant season that are detectable at annual, seasonal, and event time scales. For larger spatial scales (up to 2,000km2) the effect of MTM on water quantity is not as easily detectable. At these larger scales, other land uses can mask possible alterations in hydrology or the percentage of MTM disturbed areas becomes negligible.

Small-for-gestational age prevalence risk factors in central Appalachian states with mountain-top mining.

PubMed

Ferdosi, Hamid; Lamm, Steve H; Afari-Dwamena, Nana Ama; Dissen, Elisabeth; Chen, Rusan; Li, Ji; Feinleib, Manning

2018-01-01

To identify risk factors for small-for-gestational age (SGA) for counties in central Appalachian states (Kentucky (KY), Tennessee (TN), Virginia (VA), and West Virginia (WV)) with varied coal mining activities. Live birth certificate files (1990-2002) were used for obtaining SGA prevalence rates for mothers based on the coal mining activities of their counties of residence, mountain-top mining (MTM) activities, underground mining activities but no mountain-top mining activity (non-MTM), or having no mining activities (non-mining). Co-variable information, including maternal tobacco use, was also obtained from the live birth certificate. Adjusted odds ratios were obtained using multivariable logistic regression comparing SGA prevalence rates for counties with coal mining activities to those without coal mining activities and comparing SGA prevalence rates for counties with coal mining activities for those with and without mountain-top mining activities. Comparisons were also made among those who had reported tobacco use and those who had not. Both tobacco use prevalence and SGA prevalence were significantly greater for mining counties than for non-mining counties and for MTM counties than for non-MTM counties. Adjustment for tobacco use alone explained 50% of the increased SGA risk for mining counties and 75% of the risk for MTM counties, including demographic pre-natal care co-variables that explained 75% of the increased SGA risk for mining counties and 100% of the risk for MTM. The increased risk of SGA was limited to the third trimester births among tobacco users and independent of the mining activities of their counties of residence. This study demonstrates that the increased prevalence of SGA among residents of counties with mining activity was primarily explained by the differences in maternal tobacco use prevalence, an effect that itself was gestational-age dependent. Self-reported tobacco use marked the population at the increased risk for SGA in central Appalachian states. Int J Occup Med Environ Health 2018;31(1):11-23. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.

Temporal changes in taxonomic and functional diversity of fish assemblages downstream from mountaintop mining

USGS Publications Warehouse

Hitt, Nathaniel P.; Chambers, Douglas B.

2014-01-01

Mountaintop mining (MTM) affects chemical, physical, and hydrological properties of receiving streams, but the long-term consequences for fish-assemblage structure and function are poorly understood. We sampled stream fish assemblages using electrofishing techniques in MTM exposure sites and reference sites within the Guyandotte River basin, USA, during 2010–2011. We calculated indices of taxonomic diversity (species richness, abundance, Shannon diversity) and functional diversity (functional richness, functional evenness, functional divergence) to compare exposure and reference assemblages between seasons (spring and autumn) and across years (1999–2011). We based temporal comparisons on 2 sites that were sampled during 1999–2001 by Stauffer and Ferreri (2002). Exposure assemblages had lower taxonomic and functional diversity than reference assemblages or simulated assemblages that accounted for random variation. Differences in taxonomic composition between reference and exposure assemblages were associated with conductivity and aqueous Se concentrations. Exposure assemblages had fewer species, lower abundances, and less biomass than reference assemblages across years and seasons. Green Sunfish (Lepomis cyanellus) and Creek Chub (Semotilus atromaculatus) became numerically dominant in exposure assemblages over time because of their persistence and losses of other taxa. In contrast, species richness increased over time in reference assemblages, a result that may indicate recovery from drought. Mean individual biomass increased as fish density decreased and most obligate invertivores were apparently extirpated at MTM exposure sites. Effects of MTM were not related to physical-habitat conditions but were associated with water-quality variables, which may limit quality and availability of benthic macroinvertebrate prey. Simulations revealed effects of MTM that could not be attributed to random variation in fish assemblage structure.

The Professional Culture of Community Pharmacy and the Provision of MTM Services.

PubMed

Rosenthal, Meagen M; Holmes, Erin R

2018-03-21

The integration of advanced pharmacy services into community pharmacy practice is not complete. According to implementation research understanding professional culture, as a part of context, may provide insights for accelerating this process. There are three objectives in this study. The first objective of this study was to validate an adapted version of an organizational culture measure in a sample of United States' (US) community pharmacists. The second objective was to examine potential relationships between the cultural factors identified using the validated instrument and a number of socialization and education variables. The third objective was to examine any relationships between the scores on the identified cultural factors and the provision of MTM services. This study was a cross-sectional online survey for community pharmacists in the southeastern US. The survey contained questions on socialization/education, respondents' self-reported provision of medication therapy management (MTM) services, and the organizational culture profile (OCP). Analyses included descriptive statistics, a principle components analysis (PCA), independent samples t-test, and multivariate ordinal regression. A total of 303 surveys were completed. The PCA revealed a six-factor structure: social responsibility, innovation, people orientation, competitiveness, attention to detail, and reward orientation. Further analysis revealed significant relationships between social responsibility and years in practice, and people orientation and attention to detail and pharmacists' training and practice setting. Significant positive relationships were observed between social responsibility, innovation, and competitiveness and the increased provision of MTM services. The significant relationships identified between the OCP factors and community pharmacist respondents' provision of MTM services provides an important starting point for developing interventions to improve the uptake of practice change opportunities.

Nonlinear surface waves at ferrite-metamaterial waveguide structure

NASA Astrophysics Data System (ADS)

Hissi, Nour El Houda; Mokhtari, Bouchra; Eddeqaqi, Noureddine Cherkaoui; Shabat, Mohammed Musa; Atangana, Jacques

2016-09-01

A new ferrite slab made of a metamaterial (MTM), surrounded by a nonlinear cover cladding and a ferrite substrate, was shown to support unusual types of electromagnetic surface waves. We impose the boundary conditions to derive the dispersion relation and others necessary to formulate the proposed structure. We analyse the dispersion properties of the nonlinear surface waves and we calculate the associated propagation index and the film-cover interface nonlinearity. In the calculation, several sets of the permeability of the MTM are considered. Results show that the waves behaviour depends on the values of the permeability of the MTM, the thickness of the waveguide and the film-cover interface nonlinearity. It is also shown that the use of the singular solutions to the electric field equation allows to identify several new properties of surface waves which do not exist in conventional waveguide.

Manufacturing Work Measurement System Evaluation. Reference Guide

DTIC Science & Technology

1987-04-01

discussions with users of the MTM-MEK predetermined time system. The coranents listed below are based on these discussions and, while a broad range...discussions with users of the MTM-V predeterroined time system. The coranents listed below are based on these discussions and, while a broad range of...industries were sampled, coranents should not be considered universal and therefore may not be applicable to all manufacturing environments: 0 Easy to

A Multiscale Material Testing System for In Situ Optical and Electron Microscopes and Its Application

PubMed Central

Ye, Xuan; Cui, Zhiguo; Fang, Huajun; Li, Xide

2017-01-01

We report a novel material testing system (MTS) that uses hierarchical designs for in-situ mechanical characterization of multiscale materials. This MTS is adaptable for use in optical microscopes (OMs) and scanning electron microscopes (SEMs). The system consists of a microscale material testing module (m-MTM) and a nanoscale material testing module (n-MTM). The MTS can measure mechanical properties of materials with characteristic lengths ranging from millimeters to tens of nanometers, while load capacity can vary from several hundred micronewtons to several nanonewtons. The m-MTM is integrated using piezoelectric motors and piezoelectric stacks/tubes to form coarse and fine testing modules, with specimen length from millimeters to several micrometers, and displacement distances of 12 mm with 0.2 µm resolution for coarse level and 8 µm with 1 nm resolution for fine level. The n-MTM is fabricated using microelectromechanical system technology to form active and passive components and realizes material testing for specimen lengths ranging from several hundred micrometers to tens of nanometers. The system’s capabilities are demonstrated by in-situ OM and SEM testing of the system’s performance and mechanical properties measurements of carbon fibers and metallic microwires. In-situ multiscale deformation tests of Bacillus subtilis filaments are also presented. PMID:28777341

Decadal time scale variability recorded in the Quelccaya summit ice core δ18O isotopic ratio series and its relation with the sea surface temperature

NASA Astrophysics Data System (ADS)

Mélice, J. L.; Roucou, P.

The spectral characteristics of the δ18O isotopic ratio time series of the Quelccaya ice cap summit core are investigated with the multi taper method (MTM), the singular spectrum analysis (SSA) and the wavelet transform (WT) techniques for the 500 y long 1485-1984 period. The most significant (at the 99.8% level) cycle according to the MTM F-test has a period centered at 14.4 y while the largest variance explaining oscillation according to the SSA technique has a period centered at 12.9 y. The stability over time of these periods is investigated by performing evolutive MTM and SSA on the 500 y long δ18O series with a 100 y wide moving window. It is shown that the cycles with largest amplitude and that the oscillations with largest extracting variance have corresponding periods aggregated around 13.5 y that are very stable over the period between 1485 and 1984. The WT of the same isotopic time series reveals the existence of a main oscillation around 12 y which are also very stable in time. The relation between the isotopic data at Quelccaya and the annual sea surface temperature (SST) field anomalies is then evaluated for the overlapping 1919-1984 period. Significant global correlation and significant coherency at 12.1 y are found between the isotopic series and the annual global sea surface temperature (GSST) series. Moreover, the correlation between the low (over 8 y) frequency component of the isotopic time series and the annual SST field point out significant values in the tropical North Atlantic. This region is characterized by a main SST variability at 12.8 y. The Quelccaya δ18O isotopic ratio series may therefore be considered as a good recorder of the tropical North Atlantic SSTs. This may be explained by the following mechanism: the water vapor amount evaporated by the tropical North Atlantic is function of the SST. So is the water vapor δ18O isotopic ratio. This water vapor is advected during the rainy season by northeast winds and precipitates at the Quelccaya summit with its tropical North Atlantic isotopic signature. It is also suggested from this described stability of the decadal time scale variability observed in the Quelccaya isotopic series, that the decadal time scale GSST variability was also stable during the last five centuries.

[Better multidisciplinary team meetings are linked to better care].

PubMed

van Drielen, Eveline; de Vries, Antoinette W; Ottevanger, P B Nelleke; Hermens, Rosella P M G

2012-01-01

Discussing a patient in an oncology multidisciplinary team meeting (MTM) increases the value of the quality of the treatment chosen. MTMs are increasingly mentioned in guidelines and indicator sets. Based on literature review and observations, the Comprehensive Cancer Centre Netherlands (CCCNL), in collaboration with IQ Healthcare and the Department of Medical Oncology of the UMC St Radboud Nijmegen in the Netherlands, has conducted research into the quality criteria for a good MTM. Two of our studies show that the organisation of MTMs can be significantly improved. Based on the results, we developed a checklist to accomplish this. The most significant areas of improvement for optimising the organisation of MTMs are: (a) the presence of specialists from all relevant disciplines; (b) a capable chairman who promotes the efficiency of the MTM; and (c) the reduction of intruding factors, such as mobile phones and participants who walk in and out.

Impact of an Elective Course on Pharmacy Students’ Attitudes, Beliefs, and Competency Regarding Medicare Part D

PubMed Central

Patel, Rajul A.; Thai, Huong K.; Phou, Christine M.; Walberg, Mark P.; Woelfel, Joseph A.; Carr-Lopez, Sian M.; Chan, Emily K.

2012-01-01

Objective. To determine the impact of an elective course on pharmacy students’ perceptions, knowledge, and confidence regarding Medicare Part D, medication therapy management (MTM), and immunizations. Design. Thirty-three pharmacy students were enrolled in a Medicare Part D elective course that included both classroom instruction and experiential training. Assessment. Students’ self-reported confidence in and knowledge of Part D significantly improved upon course completion. End-of-course student perceptions about the relative importance of various aspects of MTM interventions and their confidence in performing MTM services significantly improved from those at the beginning of the course. Students’ confidence in performing immunizations also increased significantly from the start of the course. Conclusion. A classroom course covering Medicare Part D with an experiential requirement serving beneficiaries can improve students’ attitudes and knowledge about Medicare Part D and their confidence in providing related services to beneficiaries in the community. PMID:22761532

Methylation of arsenic by recombinant human wild-type arsenic (+ 3 oxidation state) methyltransferase and its methionine 287 threonine (M287T) polymorph: Role of glutathione

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ding, Lan; Saunders, R. Jesse; Drobná, Zuzana

2012-10-01

Arsenic (+ 3 oxidation state) methyltransferase (AS3MT) is the key enzyme in the pathway for methylation of arsenicals. A common polymorphism in the AS3MT gene that replaces a threonyl residue in position 287 with a methionyl residue (AS3MT/M287T) occurs at a frequency of about 10% among populations worldwide. Here, we compared catalytic properties of recombinant human wild-type (wt) AS3MT and AS3MT/M287T in reaction mixtures containing S-adenosylmethionine, arsenite (iAs{sup III}) or methylarsonous acid (MAs{sup III}) as substrates and endogenous or synthetic reductants, including glutathione (GSH), a thioredoxin reductase (TR)/thioredoxin (Trx)/NADPH reducing system, or tris (2-carboxyethyl) phosphine hydrochloride (TCEP). With either TR/Trx/NADPHmore » or TCEP, wtAS3MT or AS3MT/M287T catalyzed conversion of iAs{sup III} to MAs{sup III}, methylarsonic acid (MAs{sup V}), dimethylarsinous acid (DMAs{sup III}), and dimethylarsinic acid (DMAs{sup V}); MAs{sup III} was converted to DMAs{sup III} and DMAs{sup V}. Although neither enzyme required GSH to support methylation of iAs{sup III} or MAs{sup III}, addition of 1 mM GSH decreased K{sub m} and increased V{sub max} estimates for either substrate in reaction mixtures containing TR/Trx/NADPH. Without GSH, V{sub max} and K{sub m} values were significantly lower for AS3MT/M287T than for wtAS3MT. In the presence of 1 mM GSH, significantly more DMAs{sup III} was produced from iAs{sup III} in reactions catalyzed by the M287T variant than in wtAS3MT-catalyzed reactions. Thus, 1 mM GSH modulates AS3MT activity, increasing both methylation rates and yield of DMAs{sup III}. AS3MT genotype exemplified by differences in regulation of wtAS3MT and AS3MT/M287T-catalyzed reactions by GSH may contribute to differences in the phenotype for arsenic methylation and, ultimately, to differences in the disease susceptibility in individuals chronically exposed to inorganic arsenic. -- Highlights: ► Human AS3MT and AS3MT(M287T) require a dithiol reductant for optimal activity. ► Both enzymes methylate arsenite to tri- and pentavalent methylated metabolites. ► Neither enzyme requires glutathione (GSH) to methylate arsenite or methylarsonite. ► However, in presence of a dithiol addition of 1 mM GSH increases methylation rates. ► In presence of 1 mM GSH, AS3MT(M287T) produces more dimethylarsinite than AS3MT.« less

Using satellite data on meteorological and vegetation characteristics and soil surface humidity in the Land Surface Model for the vast territory of agricultural destination

NASA Astrophysics Data System (ADS)

Muzylev, Eugene; Startseva, Zoya; Uspensky, Alexander; Vasilenko, Eugene; Volkova, Elena; Kukharsky, Alexander

2017-04-01

The model of water and heat exchange between vegetation covered territory and atmosphere (LSM, Land Surface Model) for vegetation season has been developed to calculate soil water content, evapotranspiration, infiltration of water into the soil, vertical latent and sensible heat fluxes and other water and heat balances components as well as soil surface and vegetation cover temperatures and depth distributions of moisture and temperature. The LSM is suited for utilizing satellite-derived estimates of precipitation, land surface temperature and vegetation characteristics and soil surface humidity for each pixel. Vegetation and meteorological characteristics being the model parameters and input variables, correspondingly, have been estimated by ground observations and thematic processing measurement data of scanning radiometers AVHRR/NOAA, SEVIRI/Meteosat-9, -10 (MSG-2, -3) and MSU-MR/Meteor-M № 2. Values of soil surface humidity has been calculated from remote sensing data of scatterometers ASCAT/MetOp-A, -B. The case study has been carried out for the territory of part of the agricultural Central Black Earth Region of European Russia with area of 227300 km2 located in the forest-steppe zone for years 2012-2015 vegetation seasons. The main objectives of the study have been: - to built estimates of precipitation, land surface temperatures (LST) and vegetation characteristics from MSU-MR measurement data using the refined technologies (including algorithms and programs) of thematic processing satellite information matured on AVHRR and SEVIRI data. All technologies have been adapted to the area of interest; - to investigate the possibility of utilizing satellite-derived estimates of values above in the LSM including verification of obtained estimates and development of procedure of their inputting into the model. From the AVHRR data there have been built the estimates of precipitation, three types of LST: land skin temperature Tsg, air temperature at a level of vegetation cover (taken for vegetation temperature) Ta and efficient radiation temperature Ts.eff, as well as land surface emissivity E, normalized difference vegetation index NDVI, vegetation cover fraction B, and leaf area index LAI. The SEVIRI-based retrievals have included precipitation, LST Tls and Ta, E at daylight and nighttime, LAI (daily), and B. From the MSU-MR data there have been retrieved values of all the same characteristics as from the AVHRR data. The MSU-MR-based daily and monthly sums of precipitation have been calculated using the developed earlier and modified Multi Threshold Method (MTM) intended for the cloud detection and identification of its types around the clock as well as allocation of precipitation zones and determination of instantaneous maximum rainfall intensities for each pixel at that the transition from assessing rainfall intensity to estimating their daily values is a key element of the MTM. Measurement data from 3 IR MSU-MR channels (3.8, 11 i 12 μm) as well as their differences have been used in the MTM as predictors. Controlling the correctness of the MSU-MR-derived rainfall estimates has been carried out when comparing with analogous AVHRR- and SEVIRI-based retrievals and with precipitation amounts measured at the agricultural meteorological station of the study region. Probability of rainfall zones determination from the MSU-MR data, to match against the actual ones, has been 75-85% as well as for the AVHRR and SEVIRI data. The time behaviors of satellite-derived and ground-measured daily and monthly precipitation sums for vegetation season and yeaŗ correspondingly, have been in good agreement with each other although the first ones have been smoother than the latter. Discrepancies have existed for a number of local maxima for which satellite-derived precipitation estimates have been less than ground-measured values. It may be due to the different spatial scales of areal satellite-derived and point ground-based estimates. Some spatial displacement of the satellite-determined rainfall maxima and minima regarding to ground-based data can be explained by the discrepancy between the cloud location on satellite images and in reality at high angles of the satellite sightings and considerable altitudes of the cloud tops. Reliability of MSU-MR-derived rainfall estimates at each time step obtained using the MTM has been verified by comparing their values determined from the MSU-MR, AVHRR and SEVIRI measurements and distributed over the study area with similar estimates obtained by interpolation of ground observation data. The MSU-MR-derived estimates of temperatures Tsg, Ts.eff, and Ta have been obtained using computational algorithm developed on the base of the MTM and matured on AVHRR and SEVIRI data for the region under investigation. Since the apparatus MSU-MR is similar to radiometer AVHRR, the developed methods of satellite estimating Tsg, Ts.eff, and Ta from AVHRR data could be easily transferred to the MSU-MR data. Comparison of the ground-measured and MSU-MR-, AVHRR- and SEVIRI-derived LSTs has shown that the differences between all the estimates for the vast majority of observation terms have not exceed the RMSE of these quantities built from the AVHRR data. The similar conclusion has been also made from the results of building the time behavior of the MSU-MR-derived value of LAI for vegetation season. Satellite-based estimates of precipitation, LST, LAI and B have been utilized in the model with the help of specially developed procedures of replacing these values determined from observations at agricultural meteorological stations by their satellite-derived values taking into account spatial heterogeneity of their fields. Adequacy of such replacement has been confirmed by the results of comparing modeled and ground-measured values of soil moisture content W and evapotranspiration Ev. Discrepancies between the modeled and ground-measured values of W and Ev have been in the range of 10-15 and 20-25 %, correspondingly. It may be considered as acceptable result. Resulted products of the model calculations using satellite data have been spatial fields of W, Ev, vertical sensible and latent heat fluxes and other water and heat regime characteristics for the region of interest over the year 2012-2015 vegetation seasons. Thus, there has been shown the possibility of utilizing MSU-MR/Meteor-M №2 data jointly with those of other satellites in the LSM to calculate characteristics of water and heat regimes for the area under consideration. Besides the first trial estimations of the soil surface moisture from ASCAT scatterometers data for the study region have been obtained for the years 2014-2015 vegetation seasons, their comparison has been performed with the results of modeling for several agricultural meteorological stations of the region that has been carried out utilizing ground-based and satellite data, specific requirements for the obtained information have been formulated. To date, estimates of surface moisture built from ASCAT data can be used for the selection of the model soil parameter values and the initial soil moisture conditions for the vegetation season.

Analyzing the costs to deliver medication therapy management services.

PubMed

Rupp, Michael T

2011-01-01

To provide pharmacy managers and consultant pharmacists with a step-by-step approach for analyzing of the costs of delivering medication therapy management (MTM) services and to describe use of a free online software application for determining costs of delivering MTM. The process described is applicable to community pharmacies and consultant pharmacists who provide MTM services from nonpharmacy settings. The PharmAccount Service Cost Calculator is an Internet- based software application that uses a guided online interview to collect information needed to conduct a comprehensive cost analysis of any specialized pharmacy service. In addition to direct variable and fixed costs, the software automatically allocates indirect and overhead costs to the service and generates an itemized report that details the components of service delivery costs. The service cost calculator is sufficiently flexible to support the analysis of virtually any specialized pharmacy service, irrespective of whether the service is being delivered from a physical pharmacy. The software application allows users to perform sensitivity analysis to quickly determine the potential impact that alternate scenarios would have on service delivery cost. It is therefore particularly well suited to assist in the design and planning of a new pharmacy service. Good management requires that the cost implications of service delivery decisions are known and considered. Analyzing the cost of an MTM service is an important step in developing a sustainable business model.

[Prostate cancer: Quality assessment of clinical management in the Midi-Pyrenean region in 2011].

PubMed

Daubisse-Marliac, L; Lamy, S; Lunardi, P; Tollon, C; Thoulouzan, M; Latorzeff, I; Bauvin, E; Grosclaude, P

2017-02-01

Assessing the quality of the clinical management of prostate cancer in the Midi-Pyrenean region in 2011. The study population was randomly selected among new cases of prostate cancer presented in Multidisciplinary Team Meeting (MTM) in 2011. The indicators defined with the professionals have evaluated the quality of the diagnostic care, when treatment started and at the time of the MTM. Six hundred and thirty-three new patients were included (median age at diagnosis=69years, min: 48; max: 93). In diagnostic period, 92% of patients had a prostate biopsy. Performing a pelvic MRI, an abdomino-pelvic CT and bone scintigraphy concerned respectively 53%, 55% and 61% of intermediate or high-risk patients. The Gleason score, surgical margins and pathological stage were included in over 98% patient records treated by radical prostatectomy. A PSA assay in 3months after prostatectomy was found in 59% of surgical patients. The MTM was performed before treatment to 83% of patients. About three-quarters of surgical patients with stage pT≥3 or pN1 or with no healthy margins were discussed in MTM after surgery. Most of the studied indicators reach a high level. However, the lower level of realization of complementary examinations may question about their real place, accessibility and traceability. 4. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Medication therapy management and condition care services in a community-based employer setting.

PubMed

Johannigman, Mark J; Leifheit, Michael; Bellman, Nick; Pierce, Tracey; Marriott, Angela; Bishop, Cheryl

2010-08-15

A program in which health-system pharmacists and pharmacy technicians provide medication therapy management (MTM), wellness, and condition care (disease management) services under contract with local businesses is described. The health-system pharmacy department's Center for Medication Management contracts directly with company benefits departments for defined services to participating employees. The services include an initial wellness and MTM session and, for certain patients identified during the initial session, ongoing condition care. The initial appointment includes a medication history, point-of-care testing for serum lipids and glucose, body composition analysis, and completion of a health risk assessment. The pharmacist conducts a structured MTM session, reviews the patient's test results and risk factors, provides health education, discusses opportunities for cost savings, and documents all activities on the patient's medication action plan. Eligibility for the condition care program is based on a diagnosis of diabetes, hypertension, asthma, heart failure, or hyperlipidemia or elevation of lipid or glucose levels. Findings are summarized for employers after the initial wellness screening and at six-month intervals. Patients receiving condition care sign a customized contract, establish goals, attend up to four MTM sessions per year, and track their information on a website; employers may offer incentives for participation. When pharmacists recommend adjustments to therapy or cost-saving changes, it is up to patients to discuss these with their physician. A survey completed by each patient after the initial wellness session has indicated high satisfaction. Direct cost savings related to medication changes have averaged $253 per patient per year. Total cost savings to companies in the first year of the program averaged $1011 per patient. For the health system, the program has been financially sustainable. Key laboratory values indicate positive clinical outcomes. A business model in which health-system pharmacists provide MTM and condition care services for company employees has demonstrated successful outcomes in terms of patient satisfaction, cost savings, and clinical benefits.

Peripheral Nerve Stimulation Characteristics of an Asymmetric Head-Only Gradient Coil Compatible with a High-Channel-Count Receiver Array

PubMed Central

Lee, Seung-Kyun; Mathieu, Jean-Baptiste; Graziani, Dominic; Piel, Joseph; Budesheim, Eric; Fiveland, Eric; Hardy, Christopher J.; Tan, Ek Tsoon; Amm, Bruce; Foo, Thomas K.-F; Bernstein, Matt A.; Huston, John; Shu, Yunhong; Schenck, John F.

2015-01-01

Purpose To characterize peripheral nerve stimulation (PNS) of an asymmetric head-only gradient coil that is compatible with a commercial high-channel-count receive-only array. Methods Two prototypes of an asymmetric head-only gradient coil set, with 42-cm inner diameter, were constructed for brain imaging at 3T with maximum performance specifications of up to 85 mT/m and 708 T/m/s. 24 volunteer tests were performed to measure PNS thresholds with the transverse (X, left/right; Y, anterior/posterior) gradient coils of both prototypes. 14 volunteers were also tested for the Z-gradient PNS in the second prototype, and were additionally scanned with high-slew-rate EPI immediately after the PNS tests. Results For both prototypes, the Y-gradient PNS threshold was markedly higher than the X-gradient. The Z-gradient threshold was intermediate between those for the X- and Y-coils. Out of the 24 volunteer subjects, only two experienced Y-gradient PNS at 80 mT/m, 500 T/m/s. All volunteers underwent the EPI scan without PNS when the readout direction was set to A/P. Conclusion Measured PNS characteristics of asymmetric head-only gradient coil prototypes indicate that such coils, especially in the A/P direction, can be used for fast EPI readout in high-performance neuroimaging scans with substantially reduced PNS concerns compared to conventional whole-body gradient coils. PMID:26628078

Ongoing compression triggered exhumation of the orogenic crust in the Variscan Maures-Tanneron Massif, France - Geological arguments and thermo-mechanical tests

NASA Astrophysics Data System (ADS)

Gerbault, Muriel; Schneider, Julie; Reverso-Peila, Alexandre; Corsini, Michel

2016-04-01

The Maures-Tanneron Massif (MTM), together with Corsica and Sardinia, hosted the South-Eastern Variscan belt and record a continuous evolution from continental collision to exhumation. We present a synthesis of the available geological and geochronogical data that explores the transition from convergence to perpendicular Permean extension in the MTM (at ~ 325 Ma ± 25 My). The migmatitic Internal Zone that composes the Western MTM displays structural clues such as backthrusting and magmatic foliations, and metamorphic data indicating exhumation of deep seated partially molten rocks at an apparent heating rate of 1-2 °C/km/My from ca. 345 Ma to 320 Ma. This suggests vertical advective heat transport during continued N140° convergence (D2 phase). In contrast at the same time, the low grade External zone composing the Eastern part of the MTM recorded exhumation of more conductive patterns at an apparent rate of 0.3-0.6 °C/km/My. It is only from ca. 320 Ma that transcurrent motion dominates in the Internal zone and progressively leaves way to N-S strecthing (D3 phase), indicative of orogenic collapse and extension and in asociation with emplacement of larger volumes of magmatism in the crust. Thermo-mechanical modeling complements this synthesis in order to highlight the conditions under which deep seated HP units could melt and massively start to exhume during maintained convergence (phase D2). Accounting for temperature dependent elasto-visco-plastic rheologies, our models explore the dynamics of an orogenic prism starting from a dis-equilibrated state just after slab break-off or delamination, at ca. 350 Ma. We simulate the development of gravitational instabilities in partially melting crust, a process that is already well known to depend on strain-rate, heat sources and strength layering. In order to reproduce the exhumation patterns of rocks from ~50 km depth over the appropriate time-scale (>20 My) and spatial extent (>100 km), a best fit was obtained with a mean convergence rate of 0.5 cm/yr and no exceptional surface processes. Internal heating has a crucial effect and mostly resulted from the radiogenic decay of stacked felsic crustal units. However alternation with mafic units is also necessary in order to prevent lateral spreading of the orogeny. A low viscosity partially molten (eg. felsic) crust also permits mechanical decoupling of surface deformation from the deeper mantle domains, thus reducing the differences due to either a shallow asthenosphere or a competent mantle lithosphere under the orogeny. A shallow asthenosphere produces too warm and fast exhumation. The bulk viscosity of the partially molten orogenic crust controls the timing of exhumation, pointing to the need for further constraints to link the behaviour at different scales of partially molten crust. The MTM witnesses the typical competition between far-field plate convergence and internal body forces, and we plead for a subsequent progressive evolution of transpression to perpendicular extension (still to be tackled with 3D modeling).

Compact Single-Layer Traveling-Wave Antenna DesignUsing Metamaterial Transmission Lines

NASA Astrophysics Data System (ADS)

Alibakhshikenari, Mohammad; Virdee, Bal Singh; Limiti, Ernesto

2017-12-01

This paper presents a single-layer traveling-wave antenna (TWA) that is based on composite right/left-handed (CRLH)-metamaterial (MTM) transmission line (TL) structure, which is implemented by using a combination of interdigital capacitors and dual-spiral inductive slots. By embedding dual-spiral inductive slots inside the CRLH MTM-TL results in a compact TWA. Dimensions of the proposed CRLH MTM-TL TWA is 21.5 × 30.0 mm2 or 0.372λ0 × 0.520λ0 at 5.2 GHz (center frequency). The fabricated TWA operates over 1.8-8.6 GHz with a fractional bandwidth greater than 120%, and it exhibits a peak gain and radiation efficiency of 4.2 dBi and 81%, respectively, at 5 GHz. By avoiding the use of lumped components, via-holes or defected ground structures, the proposed TWA design is economic for mass production as well as easy to integrate with wireless communication systems.

Ultra-small single-negative electric metamaterials for electromagnetic coupling reduction of microstrip antenna array.

PubMed

Xu, He-Xiu; Wang, Guang-Ming; Qi, Mei-Qing; Zeng, Hui-Yong

2012-09-24

We report initially the design, fabrication and measurement of using waveguided electric metamaterials (MTM) in the design of closely-spaced microtrip antenna arrays with mutual coupling reduction. The complementary spiral ring resonators (CSRs) which exhibit single negative resonant permittivity around 3.5GHz are used as the basic electric MTM element. For verification, two CSRs with two and three concentric rings are considered, respectively. By properly arranging these well engineered waveguided MTMs between two H-plane coupled patch antennas, both numerical and measured results indicate that more than 8.4 dB mutual coupling reduction is obtained. The mechanism has been studied from a physical insight. The electric MTM element is electrically small, enabling the resultant antenna array to exhibit a small separation (λo/8 at the operating wavelength) and thus a high directivity. The proposed strategy opens an avenue to new types of antenna with super performances and can be generalized for other electric resonators.

A New Mechanism of Sound Generation in Songbirds

NASA Astrophysics Data System (ADS)

Goller, Franz; Larsen, Ole N.

1997-12-01

Our current understanding of the sound-generating mechanism in the songbird vocal organ, the syrinx, is based on indirect evidence and theoretical treatments. The classical avian model of sound production postulates that the medial tympaniform membranes (MTM) are the principal sound generators. We tested the role of the MTM in sound generation and studied the songbird syrinx more directly by filming it endoscopically. After we surgically incapacitated the MTM as a vibratory source, zebra finches and cardinals were not only able to vocalize, but sang nearly normal song. This result shows clearly that the MTM are not the principal sound source. The endoscopic images of the intact songbird syrinx during spontaneous and brain stimulation-induced vocalizations illustrate the dynamics of syringeal reconfiguration before phonation and suggest a different model for sound production. Phonation is initiated by rostrad movement and stretching of the syrinx. At the same time, the syrinx is closed through movement of two soft tissue masses, the medial and lateral labia, into the bronchial lumen. Sound production always is accompanied by vibratory motions of both labia, indicating that these vibrations may be the sound source. However, because of the low temporal resolution of the imaging system, the frequency and phase of labial vibrations could not be assessed in relation to that of the generated sound. Nevertheless, in contrast to the previous model, these observations show that both labia contribute to aperture control and strongly suggest that they play an important role as principal sound generators.

Acute effects of single and multiple level thoracic manipulations on chronic mechanical neck pain: a randomized controlled trial

PubMed Central

Puntumetakul, Rungthip; Suvarnnato, Thavatchai; Werasirirat, Phurichaya; Uthaikhup, Sureeporn; Yamauchi, Junichiro; Boucaut, Rose

2015-01-01

Background Thoracic spine manipulation has become a popular alternative to local cervical manipulative therapy for mechanical neck pain. This study investigated the acute effects of single-level and multiple-level thoracic manipulations on chronic mechanical neck pain (CMNP). Methods Forty-eight patients with CMNP were randomly allocated to single-level thoracic manipulation (STM) at T6–T7 or multiple-level thoracic manipulation (MTM), or to a control group (prone lying). Cervical range of motion (CROM), visual analog scale (VAS), and the Thai version of the Neck Disability Index (NDI-TH) scores were measured at baseline, and at 24-hour and at 1-week follow-up. Results At 24-hour and 1-week follow-up, neck disability and pain levels were significantly (P<0.05) improved in the STM and MTM groups compared with the control group. CROM in flexion and left lateral flexion were increased significantly (P<0.05) in the STM group when compared with the control group at 1-week follow-up. The CROM in right rotation was increased significantly after MTM compared to the control group (P<0.05) at 24-hour follow-up. There were no statistically significant differences in neck disability, pain level at rest, and CROM between the STM and MTM groups. Conclusion These results suggest that both single-level and multiple-level thoracic manipulation improve neck disability, pain levels, and CROM at 24-hour and 1-week follow-up in patients with CMNP. PMID:25624764

Identification of a mutation in the MTM1 gene, associated with X-linked myotubular myopathy, in a Greek family

PubMed Central

Fidani, L; Karagianni, P; Tsakalidis, C; Mitsiako, G; Hatziioannidis, I; Biancalana, V; Nikolaidis, N

2011-01-01

X-linked myotubular myopathy (XLMTM) is a rare congenital myopathy, usually characterized by severe hypotonia and respiratory insufficiency at birth, in affected, male infants. The disease is causally associated with mutations in the MTM1 gene, coding for phosphatase myotubularin. We report a severe case of XLMTM with a novel mutation, at a donor splicing site (c.1467+1G) previously associated with severe phenotype. The mutation was also identified in the patient's mother, providing an opportunity for sound genetic counseling. PMID:22435031

Identification of a mutation in the MTM1 gene, associated with X-linked myotubular myopathy, in a Greek family.

PubMed

Fidani, L; Karagianni, P; Tsakalidis, C; Mitsiako, G; Hatziioannidis, I; Biancalana, V; Nikolaidis, N

2011-07-01

X-linked myotubular myopathy (XLMTM) is a rare congenital myopathy, usually characterized by severe hypotonia and respiratory insufficiency at birth, in affected, male infants. The disease is causally associated with mutations in the MTM1 gene, coding for phosphatase myotubularin. We report a severe case of XLMTM with a novel mutation, at a donor splicing site (c.1467+1G) previously associated with severe phenotype. The mutation was also identified in the patient's mother, providing an opportunity for sound genetic counseling.

Integrating pharmacogenomics into pharmacy practice via medication therapy management.

PubMed

Reiss, Susan M

2011-01-01

To explore the application and integration of pharmacogenomics in pharmacy clinical practice via medication therapy management (MTM) to improve patient care. Department of Health & Human Services (HHS) Personalized Health Care Initiative, Food and Drug Administration (FDA) pharmacogenomics activity, and findings from the Utilizing E-Prescribing Technologies to Integrate Pharmacogenomics into Prescribing and Dispensing Practices Stakeholder Workshop, convened by the American Pharmacists Association (APhA) on March 5, 2009. Participants at the Stakeholder Workshop included diverse representatives from pharmacy, medicine, pathology, health information technology (HIT), standards, science, academia, government, and others with a key interest in the clinical application of pharmacogenomics. In 2006, HHS initiated the Personalized Health Care Initiative with the goal of building the foundation for the delivery of gene-based care, which may prove to be more effective for large patient subpopulations. In the years since the initiative was launched, drug manufacturers and FDA have begun to incorporate pharmacogenomic data and applications of this information into the drug development, labeling, and approval processes. New applications and processes for using this emerging pharmacogenomics data are needed to effectively integrate this information into clinical practice. Building from the findings of a stakeholder workshop convened by APhA and the advancement of the pharmacist's collaborative role in patient care through MTM, emerging roles for pharmacists using pharmacogenomic information to improve patient care are taking hold. Realizing the potential role of the pharmacist in pharmacogenomics through MTM will require connectivity of pharmacists into the electronic health record infrastructure to permit the exchange of pertinent health information among all members of a patient's health care team. Addressing current barriers, concerns, and system limitations and developing an effective infrastructure will be necessary for pharmacogenomics to achieve its true potential. To achieve integration of pharmacogenomics into clinical practice via MTM, the pharmacy profession must define a process for the application of pharmacogenomic data into pharmacy clinical practice that is aligned with MTM service delivery, develop a viable business model for these practices, and encourage and direct the development of HIT solutions that support the pharmacist's role in this emerging field.

The cnm locus, a canine homologue of human autosomal forms of centronuclear myopathy, maps to chromosome 2.

PubMed

Tiret, Laurent; Blot, Stéphane; Kessler, Jean-Louis; Gaillot, Hugues; Breen, Matthew; Panthier, Jean-Jacques

2003-09-01

Myotubular/centronuclear myopathies are a nosological group of hereditary disorders characterised by severe architectural and metabolic remodelling of skeletal muscle fibres. In most myofibres, nuclei are found at an abnormal central position within a halo devoid of myofibrillar proteins. The X-linked form (myotubular myopathy) is the most prevalent and severe form in human, leading to death during early postnatal life. Maturation of fibres is not completed and fibres resemble myotubes. Linkage analysis in human has helped to identify MTM1 as the morbid gene. MTM1 encodes myotubularin, a dual protein phosphatase. In families in which myotubular myopathy segregates, detected mutations in MTM1 abolish the specific phosphatase activity targeting the second messenger phosphatidylinositol 3-phosphate. Autosomal forms (centronuclear) have a later onset and are often compatible with life. At birth, fibres are normally constituted but progressively follow remodelling with a secondary centralisation of nuclei. Their prevalence is low; hence, no linkage data can be performed and no molecular aetiology is known. In the Labrador Retriever, a spontaneous disorder strikingly mimics the clinical evolution of the human centronuclear myopathy. We have established a canine pedigree and show that the disorder segregates as an autosomal recessive trait in that pedigree. We have further mapped the dog locus to a region on chromosome 2 that is orthologous to human chromosome 10p. To date, no human MTM1 gene member has been mapped to this genetic region. This report thus describes the first spontaneous mammalian model of centronuclear myopathy and defines a new locus for this group of diseases.

Development of a Selective Culture Medium for Primary Isolation of the Main Brucella Species▿

PubMed Central

De Miguel, M. J.; Marín, C. M.; Muñoz, P. M.; Dieste, L.; Grilló, M. J.; Blasco, J. M.

2011-01-01

Bacteriological diagnosis of brucellosis is performed by culturing animal samples directly on both Farrell medium (FM) and modified Thayer-Martin medium (mTM). However, despite inhibiting most contaminating microorganisms, FM also inhibits the growth of Brucella ovis and some B. melitensis and B. abortus strains. In contrast, mTM is adequate for growth of all Brucella species but only partially inhibitory for contaminants. Moreover, the performance of both culture media for isolating B. suis has never been established properly. We first determined the performance of both media for B. suis isolation, proving that FM significantly inhibits B. suis growth. We also determined the susceptibility of B. suis to the antibiotics contained in both selective media, proving that nalidixic acid and bacitracin are highly inhibitory, thus explaining the reduced performance of FM for B. suis isolation. Based on these results, a new selective medium (CITA) containing vancomycin, colistin, nystatin, nitrofurantoin, and amphotericin B was tested for isolation of the main Brucella species, including B. suis. CITA's performance was evaluated using reference contaminant strains but also field samples taken from brucella-infected animals or animals suspected of infection. CITA inhibited most contaminant microorganisms but allowed the growth of all Brucella species, to levels similar to those for both the control medium without antibiotics and mTM. Moreover, CITA medium was more sensitive than both mTM and FM for isolating all Brucella species from field samples. Altogether, these results demonstrate the adequate performance of CITA medium for the primary isolation of the main Brucella species, including B. suis. PMID:21270216

TransitionRx: Impact of community pharmacy postdischarge medication therapy management on hospital readmission rate.

PubMed

Luder, Heidi R; Frede, Stacey M; Kirby, James A; Epplen, Kelly; Cavanaugh, Teresa; Martin-Boone, Jill E; Conrad, Wayne F; Kuhlmann, Diane; Heaton, Pamela C

2015-01-01

To determine if a community pharmacy-based transition of care (TOC) program that included the full scope of medication therapy management (MTM) services (TransitionRx) decreased hospital readmissions, resolved medication-related problems, and increased patient satisfaction. Prospective, quasi-experimental study. Nine Kroger Pharmacies located in Western Cincinnati. Patients older than 18 years of age and discharged from two local hospitals with a diagnosis of congestive heart failure, chronic obstructive pulmonary disease, or pneumonia. Patients were recruited from two local hospitals and referred to the community pharmacy for MTM services with the pharmacist within 1 week of discharge. Pharmacists reconciled the patients' medications, identified drug therapy problems, recommended changes to therapy, and provided self-management education. At 30 days after discharge, research personnel conducted telephone surveys, using a previously validated survey instrument, to assess hospital readmissions and patient satisfaction. Pharmacist interventions and medication-related problems were documented. A total of 90 patients completed the study. Of these, 20% of patients in the usual care group were admitted to the hospital within 30 days compared with 6.9% of patients in the intervention group (P = 0.019). In the 30 patients who received MTM services from the pharmacist, 210 interventions were made. The overall mean patient satisfaction with the TOC process was not significantly different between patients who were seen by the pharmacist and those who were not seen by the pharmacist. Community pharmacies successfully collaborated with hospitals to develop a referral process for TOC interventions. Patients who received MTM services from the pharmacist experienced significantly fewer readmissions than patients who received usual care.

Dual Tuning of Ni-Co-A (A = P, Se, O) Nanosheets by Anion Substitution and Holey Engineering for Efficient Hydrogen Evolution.

PubMed

Fang, Zhiwei; Peng, Lele; Qian, Yumin; Zhang, Xiao; Xie, Yujun; Cha, Judy J; Yu, Guihua

2018-04-18

Seeking earth-abundant electrocatalysts with high efficiency and durability has become the frontier of energy conversion research. Mixed-transition-metal (MTM)-based electrocatalysts, owing to the desirable electrical conductivity, synergistic effect of bimetal atoms, and structural stability, have recently emerged as new-generation hydrogen evolution reaction (HER) electrocatalysts. However, the correlation between anion species and their intrinsic electrocatalytic properties in MTM-based electrocatalysts is still not well understood. Here we present a novel approach to tuning the anion-dependent electrocatalytic characteristics in MTM-based catalyst for HER, using holey Ni/Co-based phosphides/selenides/oxides (Ni-Co-A, A = P, Se, O) as the model materials. The electrochemical results, combined with the electrical conductivity measurement and DFT calculation, reveal that P substitution could modulate the electron configuration, lower the hydrogen adsorption energy, and facilitate the desorption of hydrogen on the active sites in Ni-Co-A holey nanostructures, resulting in superior HER catalytic activity. Accordingly we fabricate the NCP holey nanosheet electrocatalyst for HER with an ultralow onset overpotential of nearly zero, an overpotential of 58 mV, and long-term durability, along with an applied potential of 1.56 V to boost overall water splitting at 10 mA cm -2 , among the best electrocatalysts reported for non-noble-metal catalysts to date. This work not only presents a deeper understanding of the intrinsic HER electrocatalytic properties for MTM-based electrocatalyst with various anion species but also offers new insights to better design efficient and durable water-splitting electrocatalysts.

Blood pressure kiosks for medication therapy management programs: business opportunity for pharmacists.

PubMed

Houle, Sherilyn K D; Chuck, Anderson W; Tsuyuki, Ross T

2012-01-01

To develop an economic model based on the use of pharmacy-based blood pressure kiosks for case finding of remunerable medication therapy management (MTM) opportunities. Descriptive, exploratory, nonexperimental study. Ontario, Canada, between January 2010 and September 2011. More than 7.5 million blood pressure kiosk readings were taken from 341 pharmacies. A model was developed to estimate revenues achievable by using blood pressure kiosks for 1 month to identify a cohort of patients with blood pressure of 130/80 mm Hg or more and caring for those patients during 1 year. Revenue generated from MTM programs. Pharmacies could generate an average of $12,270 (range $4,523-24,420) annually in revenue from billing for MTM services. Blood pressure kiosks can be used to identify patients with elevated blood pressure who may benefit from reimbursable pharmacist cognitive services. Revenue can be reinvested to purchase automated dispensing technology or offset pharmacy technician costs to free pharmacists to provide pharmaceutical care. Improved patient outcomes, increased patient loyalty, and improved adherence are additional potential benefits.

Spatial-frequency variability of the eddy kinetic energy in the South Atlantic Ocean

NASA Astrophysics Data System (ADS)

Cecilio, C. M.; Gherardi, D. F.; Souza, R.; Correa-Ramirez, M.

2013-05-01

In the South Atlantic Ocean (SAO) part of the inter-oceanic flow is accomplished through the issuance of anticyclonic eddies by the Agulhas Retroflection. This region, known as Agulhas Leakage (AL), is responsible by the intermittent shedding of eddies in the SAO. The propagation of these eddies into the SAO induces wave processes that allows the interaction between modes of variability of different basins, ranging from high to low frequency. Modelling studies suggests that the Indian-Atlantic inter-ocean exchange is strongly related to the structure of the wind field, in particular with the position of the maximum Southern Hemisphere westerly winds. This study aims to investigate the variations of the large-scale and regional mesoscale eddy field over the SAO using a frequency domain technique, Multiple Taper Method with Singular Value Decomposition (MTM-SVD). The MTM-SVD approach is applied to examine the individual and joint spatiotemporal variability modes of eddy kinetic energy (EKE) and winds stress. The EKE is estimated from geostrophic velocity anomalies data distributed by Aviso and winds stress from winds dataset of Cross-Calibrated Multi-Platform (CCMP) project from PO.DAAC. The impact of the AL in the SAO, was assessed first for the entire region and subsequently applied in the regions of higher mesoscale activity, which are the Brazil-Malvinas Confluence (BMC), the AL, and the Brazilian Current (BC) region. The results of local fractional variance (LFV) of EKE obtained by the MTM-SVD method show a strong significant annual variability in SAO and BC region while in BMC and in AL this frequency is weaker. In the most energetic mesoscale activity regions (BMC and AL) the pattern of variability is distinct. In the BMC region the interannual variability is dominated while in the AL region the most part of variability is associated by high frequency. The joint LFV spectrum of wind and EKE show an out-of-phase relationship between the AL region and BMC region in the interannual frequencies (3 to 5 years). The dominant frequencies can be seen in 1,5 to 3 years period band and in the intrasazonal frequencies, 0,3 to 0,5 years. The results suggests that the EKE variability patterns are different in the SAO wich might be related to the influence of eddies from AL.

Towards a deterministic KPZ equation with fractional diffusion: the stationary problem

NASA Astrophysics Data System (ADS)

Abdellaoui, Boumediene; Peral, Ireneo

2018-04-01

In this work, we investigate by analysis the possibility of a solution to the fractional quasilinear problem: where is a bounded regular domain ( is sufficient), , 1  <  q and f is a measurable non-negative function with suitable hypotheses. The analysis is done separately in three cases: subcritical, 1  <  q  <  2s critical, q  =  2s and supercritical, q  >  2s. The authors were partially supported by Ministerio de Economia y Competitividad under grants MTM2013-40846-P and MTM2016-80474-P (Spain).

Heating of metallic implants and instruments induced by gradient switching in a 1.5-Tesla whole-body unit.

PubMed

Graf, Hansjörg; Steidle, Günter; Schick, Fritz

2007-11-01

To examine gradient switching-induced heating of metallic parts. Copper and titanium frames and sheets ( approximately 50 x 50 mm(2), 1.5 mm thick, frame width = 3 mm) surrounded by air were positioned in the scanner perpendicular to the static field horizontally 20 cm off-center. During the execution of a sequence (three-dimensional [3D] true fast imaging with steady precession [True-FISP], TR = 6.4 msec) exploiting the gradient capabilities (maximum gradient = 40 mT/m, maximum slew rate = 200 T/m/second), heating was measured with an infrared camera. Radio frequency (RF) amplitude was set to zero volts. Heating of a copper frame with a narrowing to 1 mm over 20 mm at one side was examined in air and in addition surrounded by several liters of gelled saline using fiber-optic thermography. Further heating studies were performed using an artificial hip made of titanium, and an aluminum replica of the hip prosthesis with the same geometry. For the copper specimens, considerable heating (>10 degrees C) in air and in gelled saline (>1.2 degrees C) could be observed. Heating of the titanium specimens was markedly less ( approximately 1 degrees C in air). For the titanium artificial hip no heating could be detected, while the rise in temperature for the aluminum replica was approximately 2.2 degrees C. Heating of more than 10 degrees C solely due to gradient switching without any RF irradiation was demonstrated in isolated copper wire frames. Under specific conditions (high gradient duty cycle, metallic loop of sufficient inductance and low resistance, power matching) gradient switching-induced heating of conductive specimens must be considered.

Utilization of remote sensing data on meteorological and vegetation characteristics for modeling water and heat regimes of large agricultural region

NASA Astrophysics Data System (ADS)

Muzylev, Eugene; Startseva, Zoya; Uspensky, Alexander; Volkova, Elena

2016-04-01

Presently, physical-mathematical models such as SVAT (Soil-Vegetation-Atmosphere-Transfer) developed with varying degrees of detail are one of the most effective tools to evaluate the characteristics of the water and heat regimes of vegetation covered territories. The produced SVAT model is designed to calculate the soil water content, evapotranspiration (evaporation from bare soil and transpiration), infiltration of water into the soil, vertical latent and sensible heat fluxes and other water and heat regime characteristics as well as vegetation and soil surface temperatures and the temperature and soil moisture distributions in depth. The model is adapted to satellite-derived estimates of precipitation, land surface temperatures and vegetation cover characteristics. The case study has been carried out for the located in the forest-steppe zone territory of part of the agricultural Central Black Earth Region of Russia with coordinates 49° 30'-54° N and 31° -43° E and area of 227 300 km2 for years 2011-2014 vegetation seasons. The soil and vegetation characteristics are used as the model parameters and the meteorological characteristics are considered to be input variables. These values have been obtained from ground-based observations and satellite-based measurements by radiometers AVHRR/NOAA, MODIS/EOS Terra and Aqua, SEVIRI/MSG-2,-3 (Meteosat-9, -10). To provide the retrieval of meteorological and vegetation cover characteristics the new and pre-existing methods and technologies of above radiometer thematic processing data have been developed or refined. From AVHRR data there have been derived estimates of precipitation P, efficient land surface temperature (LST) Ts.eff and emissivity E, surface-air temperature at a level of vegetation cover Ta, normalized difference vegetation index NDVI, leaf area index LAI and vegetation cover fraction B. The remote sensing products LST Tls, E, NDVI, LAI derived from MODIS data and covering the study area have been downloaded from LP DAAC web-site for the same vegetation seasons. The SEVIRI data have been used to retrieve P (every three hours and daily), Tls, E, Ta (at daylight and nighttime), LAI, and B (daily). All named technologies have been adapted to the territory of interest. To verify exactness of assessing AVHRR- and MODIS-based LST (Ts.eff, Ta and Tls) the error statistics of their derivation has been investigated for various samples using comparison with in-situ measurements during the all considered vegetation seasons. When developing the method to derive LST from the SEVIRI data its validation has been carried out through comparison of given Tls retrievals with independent collocated Tls estimates generated at LSA SAF (Lisbon, Portugal).The later check of SEVIRI-derived Tls and Ta estimates has been performed by their comparing with ground-based observation data. Correctness of LAI and B estimates has been confirmed when comparing time behavior of satellite- and ground-based LAI and B during each vegetation season. The all-important part of the study is to improve the developed Multi Threshold Method (MTM) intended for assessing daily and monthly rainfall from AVHRR and SEVIRI data, to check the correctness of carried out calculations for the considered territory and to develop procedures of utilizing obtained satellite-derived estimates of precipitation in the SVAT model. The MTM allows automatic pixel-by-pixel classifying AVHRR- and SEVIRI-measured data for the cloud detection, identification of its types, allocation of precipitation zones, and determination of instantaneous maximum intensities of precipitation in the pixel range around the clock throughout the year independently of land surface type. Measurement data from 5 AVHRR and 11 SEVIRI channels as well as their differences are used in the MTM as predictors. Calibration and verification of the MTM have been carried out using observation data on daily precipitation at agricultural meteorological stations of the region. In the frame of this approach the transition from the rainfall intensity estimation to the calculation of their daily sums has been fulfilled at that two variants of this calculation have been realized which focusing on climate researches and operational monitoring. Such transition has required verifying the accuracy of the estimates obtained in both variants at each time step. This verification has included comparison of area distributions of satellite-derived precipitation estimates and analogous estimates obtained by the interpolation of ground-based observation data. The probability of correct precipitation zone detection from satellite data when comparing with ground-based meteorological observations has amounted 75-85 %. In both variants of calculating precipitation for the region of interest in addition to the fields of daily rainfall the fields of their monthly and annual sums have been built. All three sums are consistent with each other and with a ground-based observation data although the satellite-derived estimates are more "smooth" in comparison with ground-based ones. Their discrepancies are in the range of the rainfall estimation errors using the MTM and they are peculiar to the local maxima for which satellite-derived rainfall is less than ground-measured values. This may be due to different scales of space-averaged satellite and point-wise ground-based estimates. To utilize satellite-derived estimates of meteorological and vegetation characteristics in the SVAT model the procedures of replacing the ground-based values of precipitation, LST, LAI and B by corresponding satellite-derived values have been developed taking into account spatial heterogeneity of their fields. The correctness of such replacement has been confirmed by the results of comparing the values of soil water content W and evapotranspiration Ev modeled and measured at agricultural meteorological stations. In particular, when the difference of precipitation sums for the vegetation season resulted from the model calculation in both above variants having been 20% the discrepancy between corresponding modeled values of W for the same period has not exceeded 8% and the discrepancy between values of E has been within 15%. Such discrepancies are within the limits of the standard W and Ev estimation errors. The final results of the SVAT model calculation utilizing satellite data are the fields of soil water content W, evapotranspiration Ev, vertical water and heat fluxes, land surface temperatures and other water and heat regime characteristics area-distributed over the territory of interest in their dynamics for the year 2011-2014 vegetation seasons. Discrepancies between Ev and W calculation results and observation data (~ 20-25 and 10-15%) have not exceeded the standard error of their estimation which corresponds to the adopted accuracy criteria of such estimates.

The identification of solar wind waves at discrete frequencies and the role of the spectral analysis techniques

NASA Astrophysics Data System (ADS)

Di Matteo, S.; Villante, U.

2017-05-01

The occurrence of waves at discrete frequencies in the solar wind (SW) parameters has been reported in the scientific literature with some controversial results, mostly concerning the existence (and stability) of favored sets of frequencies. On the other hand, the experimental results might be influenced by the analytical methods adopted for the spectral analysis. We focused attention on the fluctuations of the SW dynamic pressure (PSW) occurring in the leading edges of streams following interplanetary shocks and compared the results of the Welch method (WM) with those of the multitaper method (MTM). The results of a simulation analysis demonstrate that the identification of the wave occurrence and the frequency estimate might be strongly influenced by the signal characteristics and analytical methods, especially in the presence of multicomponent signals. In SW streams, PSW oscillations are routinely detected in the entire range f ≈ 1.2-5.0 mHz; nevertheless, the WM/MTM agreement in the identification and frequency estimate occurs in ≈50% of events and different sets of favored frequencies would be proposed for the same set of events by the WM and MTM analysis. The histogram of the frequency distribution of the events identified by both methods suggests more relevant percentages between f ≈ 1.7-1.9, f ≈ 2.7-3.4, and f ≈ 3.9-4.4 (with a most relevant peak at f ≈ 4.2 mHz). Extremely severe thresholds select a small number (14) of remarkable events, with a one-to-one correspondence between WM and MTM: interestingly, these events reveal a tendency for a favored occurrence in bins centered at f ≈ 2.9 and at f ≈ 4.2 mHz.

TOWARDS OPERATIONAL FORECASTING OF LOWER ATMOSPHERE EFFECTS ON THE UPPER ATMOSPHERE AND IONOSPHERE: INTEGRATED DYNAMICS IN EARTH’S ATMOSPHERE (IDEA)

NASA Astrophysics Data System (ADS)

Akmaev, R. A.; Fuller-Rowell, T. J.; Wu, F.; Wang, H.; Juang, H.; Moorthi, S.; Iredell, M.

2009-12-01

The upper atmosphere and ionosphere exhibit variability and phenomena that have been associated with planetary and tidal waves originating in the lower atmosphere. To study and be able to predict the effects of these global-scale dynamical perturbations on the coupled thermosphere-ionosphere-electrodynamics system a new coupled model is being developed under the IDEA project. To efficiently cross the infamous R2O “death valley”, from the outset the IDEA project leverages the natural synergy between NOAA’s National Weather Service’s (NWS) Space Weather Prediction and Environmental Modeling Centers and a NOAA-University of Colorado cooperative institute (CIRES). IDEA interactively couples a Whole Atmosphere Model (WAM) with ionosphere-plasmasphere and electrodynamics models. WAM is a 150-layer general circulation model (GCM) based on NWS’s operational weather prediction Global Forecast System (GFS) extended from its nominal top altitude of 62 km to over 600 km. It incorporates relevant physical processes including those responsible for the generation of tidal and planetary waves in the troposphere and stratosphere. Long-term simulations reveal realistic seasonal variability of tidal waves with a substantial contribution from non-migrating tidal modes, recently implicated in the observed morphology of the ionosphere. Such phenomena as the thermospheric Midnight Temperature Maximum (MTM), previously associated with the tides, are also realistically simulated for the first time.

Wild Plant Assessment for Heavy Metal Phytoremediation Potential along the Mafic and Ultramafic Terrain in Northern Pakistan

PubMed Central

Shah, Mohammad Tahir; Khan, Sardar; Saddique, Umar; Gul, Nida; Khan, Muhammad Usman; Malik, Riffat Naseem; Farooq, Muhammad; Naz, Alia

2013-01-01

This study investigates the wild plant species for their phytoremediation potential of macro and trace metals (MTM). For this purpose, soil and wild plant species samples were collected along mafic and ultramafic terrain in the Jijal, Dubair, and Alpuri areas of Kohistan region, northern Pakistan. These samples were analyzed for the concentrations of MTM (Na, K, Ca, Mg, Fe, Mn, Pb, Zn, Cd, Cu, Cr, Ni, and Co) using atomic absorption spectrometer (AAS-PEA-700). Soil showed significant (P < .001) contamination level, while plants had greater variability in metal uptake from the contaminated sites. Plant species such as Selaginella jacquemontii, Rumex hastatus, and Plectranthus rugosus showed multifold enrichment factor (EF) of Fe, Mn, Cr, Ni, and Co as compared to background area. Results revealed that these wild plant species have the ability to uptake and accumulate higher metals concentration. Therefore, these plant species may be used for phytoremediation of metals contaminated soil. However, higher MTM concentrations in the wild plant species could cause environmental hazards in the study area, as selected metals (Fe, Mn, Cr, Ni, Co, and Pb) have toxicological concerns. PMID:24078907

Experimental Testing of a Metamaterial Slow Wave Structure for High-Power Microwave Generation

NASA Astrophysics Data System (ADS)

Shipman, K.; Prasad, S.; Andreev, D.; Fisher, D. M.; Reass, D. B.; Schamiloglu, E.; Gilmore, M.

2017-10-01

A high-power L band source has been developed using a metamaterial (MTM) to produce a double negative slow wave structure (SWS) for interaction with an electron beam. The beam is generated by a 700 kV, 6 kA short pulse (10 ns) accelerator. The design of the SWS consists of a cylindrical waveguide, loaded with alternating split-rings that are arrayed axially down the waveguide. The beam is guided down the center of the rings, where electrons interact with the MTM-SWS producing radiation. Power is extracted axially via a circular waveguide, and radiated by a horn antenna. Microwaves are characterized by an external detector placed in a waveguide. Mode characterization is performed using a neon bulb array. The bulbs are lit by the electric field, resulting in an excitation pattern that resembles the field pattern. This is imaged using an SLR camera. The MTM structure has electrically small features so breakdown is a concern. In addition to high speed cameras, a fiber-optic-fed, sub-ns photomultiplier tube array diagnostic has been developed and used to characterize breakdown light. Work supported by the Air Force Office of Scientific Research, MURI Grant FA9550-12-1-0489.

Lightweight, compact, and high-performance 3T MR system for imaging the brain and extremities.

PubMed

Foo, Thomas K F; Laskaris, Evangelos; Vermilyea, Mark; Xu, Minfeng; Thompson, Paul; Conte, Gene; Van Epps, Christopher; Immer, Christopher; Lee, Seung-Kyun; Tan, Ek T; Graziani, Dominic; Mathieu, Jean-Baptise; Hardy, Christopher J; Schenck, John F; Fiveland, Eric; Stautner, Wolfgang; Ricci, Justin; Piel, Joseph; Park, Keith; Hua, Yihe; Bai, Ye; Kagan, Alex; Stanley, David; Weavers, Paul T; Gray, Erin; Shu, Yunhong; Frick, Matthew A; Campeau, Norbert G; Trzasko, Joshua; Huston, John; Bernstein, Matt A

2018-03-13

To build and evaluate a small-footprint, lightweight, high-performance 3T MRI scanner for advanced brain imaging with image quality that is equal to or better than conventional whole-body clinical 3T MRI scanners, while achieving substantial reductions in installation costs. A conduction-cooled magnet was developed that uses less than 12 liters of liquid helium in a gas-charged sealed system, and standard NbTi wire, and weighs approximately 2000 kg. A 42-cm inner-diameter gradient coil with asymmetric transverse axes was developed to provide patient access for head and extremity exams, while minimizing magnet-gradient interactions that adversely affect image quality. The gradient coil was designed to achieve simultaneous operation of 80-mT/m peak gradient amplitude at a slew rate of 700 T/m/s on each gradient axis using readily available 1-MVA gradient drivers. In a comparison of anatomical imaging in 16 patients using T 2 -weighted 3D fluid-attenuated inversion recovery (FLAIR) between the compact 3T and whole-body 3T, image quality was assessed as equivalent to or better across several metrics. The ability to fully use a high slew rate of 700 T/m/s simultaneously with 80-mT/m maximum gradient amplitude resulted in improvements in image quality across EPI, DWI, and anatomical imaging of the brain. The compact 3T MRI system has been in continuous operation at the Mayo Clinic since March 2016. To date, over 200 patient studies have been completed, including 96 comparison studies with a clinical 3T whole-body MRI. The increased gradient performance has reliably resulted in consistently improved image quality. © 2018 International Society for Magnetic Resonance in Medicine.

Peripheral nerve stimulation characteristics of an asymmetric head-only gradient coil compatible with a high-channel-count receiver array.

PubMed

Lee, Seung-Kyun; Mathieu, Jean-Baptiste; Graziani, Dominic; Piel, Joseph; Budesheim, Eric; Fiveland, Eric; Hardy, Christopher J; Tan, Ek Tsoon; Amm, Bruce; Foo, Thomas K-F; Bernstein, Matt A; Huston, John; Shu, Yunhong; Schenck, John F

2016-12-01

To characterize peripheral nerve stimulation (PNS) of an asymmetric head-only gradient coil that is compatible with a commercial high-channel-count receive-only array. Two prototypes of an asymmetric head-only gradient coil set with a 42-cm inner diameter were constructed for brain imaging at 3T with maximum performance specifications of up to 85 mT/m and 708 T/m/s. Tests were performed in 24 volunteers to measure PNS thresholds with the transverse (x = left-right; y = anterior-posterior [A/P]) gradient coils of both prototypes. Fourteen of these 24 volunteers were also tested for the z-gradient PNS in the second prototype and were scanned with high-slew-rate echo planar imaging (EPI) immediately after the PNS tests. For both prototypes, the y-gradient PNS threshold was markedly higher than the x-gradient threshold. The z-gradient threshold was intermediate between those for the x- and y-coils. Of the 24 volunteers, only two experienced y-gradient PNS at 80 mT/m and 500 T/m/s. All volunteers underwent the EPI scan without PNS when the readout direction was set to A/P. Measured PNS characteristics of asymmetric head-only gradient coil prototypes indicate that such coils, especially in the A/P direction, can be used for fast EPI readout in high-performance neuroimaging scans with substantially reduced PNS concerns compared with conventional whole body gradient coils. Magn Reson Med 76:1939-1950, 2016. © 2015 International Society for Magnetic Resonance in Medicine. © 2015 International Society for Magnetic Resonance in Medicine.

Systemic AAV8-Mediated Gene Therapy Drives Whole-Body Correction of Myotubular Myopathy in Dogs.

PubMed

Mack, David L; Poulard, Karine; Goddard, Melissa A; Latournerie, Virginie; Snyder, Jessica M; Grange, Robert W; Elverman, Matthew R; Denard, Jérôme; Veron, Philippe; Buscara, Laurine; Le Bec, Christine; Hogrel, Jean-Yves; Brezovec, Annie G; Meng, Hui; Yang, Lin; Liu, Fujun; O'Callaghan, Michael; Gopal, Nikhil; Kelly, Valerie E; Smith, Barbara K; Strande, Jennifer L; Mavilio, Fulvio; Beggs, Alan H; Mingozzi, Federico; Lawlor, Michael W; Buj-Bello, Ana; Childers, Martin K

2017-04-05

X-linked myotubular myopathy (XLMTM) results from MTM1 gene mutations and myotubularin deficiency. Most XLMTM patients develop severe muscle weakness leading to respiratory failure and death, typically within 2 years of age. Our objective was to evaluate the efficacy and safety of systemic gene therapy in the p.N155K canine model of XLMTM by performing a dose escalation study. A recombinant adeno-associated virus serotype 8 (rAAV8) vector expressing canine myotubularin (cMTM1) under the muscle-specific desmin promoter (rAAV8-cMTM1) was administered by simple peripheral venous infusion in XLMTM dogs at 10 weeks of age, when signs of the disease are already present. A comprehensive analysis of survival, limb strength, gait, respiratory function, neurological assessment, histology, vector biodistribution, transgene expression, and immune response was performed over a 9-month study period. Results indicate that systemic gene therapy was well tolerated, prolonged lifespan, and corrected the skeletal musculature throughout the body in a dose-dependent manner, defining an efficacious dose in this large-animal model of the disease. These results support the development of gene therapy clinical trials for XLMTM. Copyright © 2017 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights reserved.

The Effects of Mountaintop Mines and Valley Fills on Aquatic ...

EPA Pesticide Factsheets

This report assesses the state of the science on the environmental impacts of mountaintop mines and valley fills (MTM-VF) on streams in the Central Appalachian Coalfields. Our review focused on the aquatic impacts of mountaintop removal coal mining, which, as its name suggests, involves removing all or some portion of the top of a mountain or ridge to expose and mine one or more coal seams. The excess overburden is disposed of in constructed fills in small valleys or hollows adjacent to the mining site. MTM-VF lead directly to five principal alterations of stream ecosystems: (1) springs, intermittent streams, and small perennial streams are permanently lost with the removal of the mountain and from burial under fill, (2) concentrations of major chemical ions are persistently elevated downstream, (3) degraded water quality reaches levels that are acutely lethal to standard laboratory test organisms, (4) selenium concentrations are elevated, reaching concentrations that have caused toxic effects in fish and birds and (5) macroinvertebrate and fish communities are consistently and significantly degraded. This report assesses the state of the science on the environmental impacts of Mountaintop Mines and Valley Fills (MTM-VF) on streams in the Central Appalachian Coalfields. The draft report will be externally peer reviewed by EPA's Science Advisory Board in early 2010.

Applying Multi-Theory Model (MTM) of Health Behavior Change to Predict Water Consumption Instead of Sugar-Sweetened Beverages.

PubMed

Sharma, Manoj; Catalano, Hannah Priest; Nahar, Vinayak K; Lingam, Vimala C; Johnson, Paul; Ford, M Allison

2017-02-25

A substantial proportion of college students to not drink enough water and consume sugar-sweetened beverages (SSBs). Consumption of SSBs is associated with weight gain, obesity, type 2 diabetes mellitus, dental carries, and increased risk for cardiovascular disease. Hence, the purpose of this study was to use the multi-theory model (MTM) in predicting initiation and sustenance of plain water consumption instead of sugar-sweetened beverages among college students. A cross-sectional study. In this cross-sectional study, a 37-item valid and reliable MTM-based survey was administered to college students in 2016 via Qualtrics at a large public university in the Southeastern United States. Overall, 410 students responded to the survey; of those, 174 were eligible for the study and completed it. Stepwise multiple regression analysis revealed that 61.8% of the variance in the initiation of drinking plain water instead of SSBs was explained by behavioral confidence (P<0.001) and changes in the physical environment (P<0.001). Further, 58.3% of the variance in the sustenance of drinking plain water instead of SSBs was explained by emotional transformation (P<0.001) and practice for change (P=0.001). Multi-theory model of health behavior change is a robust theory for predicting plain water consumption instead of SSBs in college students. Interventions should be developed based on this theory for this target population.

A design for living technology: experiments with the mind time machine.

PubMed

Ikegami, Takashi

2013-01-01

Living technology aims to help people expand their experiences in everyday life. The environment offers people ways to interact with it, which we call affordances. Living technology is a design for new affordances. When we experience something new, we remember it by the way we perceive and interact with it. Recent studies in neuroscience have led to the idea of a default mode network, which is a baseline activity of a brain system. The autonomy of artificial life must be understood as a sort of default mode that self-organizes its baseline activity, preparing for its external inputs and its interaction with humans. I thus propose a method for creating a suitable default mode as a design principle for living technology. I built a machine called the mind time machine (MTM), which runs continuously for 10 h per day and receives visual data from its environment using 15 video cameras. The MTM receives and edits the video inputs while it self-organizes the momentary now. Its base program is a neural network that includes chaotic dynamics inside the system and a meta-network that consists of video feedback systems. Using this system as the hardware and a default mode network as a conceptual framework, I describe the system's autonomous behavior. Using the MTM as a testing ground, I propose a design principle for living technology.

Evaluation of Sandwich Structure Bonding In Out-of-Autoclave Processing

NASA Technical Reports Server (NTRS)

Hou, Tan-Hung; Baughman, James M.; Zimmerman, Thomas J.; Sutter, James K.; Gardner, John M.

2010-01-01

The out-of-autoclave-vacuum-bag-only (OOA-VBO) process is low in capital expenditures compared to the traditional autoclave, however, the material challenges for OOA-VBO workable material systems are high. Presently there are few such aerospace grade prepreg materials available commercially. In this study, we evaluated processing and properties of honeycomb sandwich structure (HC/SS) panels fabricated by co-curing composite face sheet with adhesives by the OOA-VBO process in an oven. The prepreg materials were IM7/MTM 45-1 and T40-800B/5320. Adhesives studied were AF-555M, XMTA-241/PM15, FM-309-1M and FM-300K. Aluminum H/C cores with and without perforations were included. It was found that adhesives in IM7/MTM 45-1/AF-555M, T40-800B/5320/FM 309-1M and T40-800B/5320/FM-300K panels all foamed but yielded high flatwise tensile (FWT) strength values above 8,275 kPA (1,200 psi). IM7/MTM 45-1/XMTA-241/PM15 did not foam, yet yielded a low FWT strength. SEM photomicrographs revealed that the origin of this low strength was poor adhesion in the interfaces between the adhesive and face sheet composite due to poor wetting associated with the high initial viscosity of the XMTA-241/PM15 adhesive.

Investigating the 90-day oscillations using ground-based, satellite and TIME-GCM model simulation data

NASA Astrophysics Data System (ADS)

Zhao, Y.; Taylor, M.; Hagan, M. E.; Pautet, P. D.; Pugmire, J. R.; Pendleton, W. R., Jr.; Russell, J. M., III

2016-12-01

The Andes Lidar Observatory (ALO) is an upper atmospheric observatory located high in the Andes mountain range at Cerro Pachón, Chile (30.3°S, 70.7°W, 2530 m). The Utah State University (USU) Mesospheric Temperature Mapper (MTM) was deployed in August, 2009 collocated with a Na wind/temperature lidar and a meteor wind radar from University of Illinois at Urbana-Champaign (UIUC) as well as other optical instrumentation. In this presentation, we focus on the characteristics of a unique 90-day oscillation identified in the first 18 months in both the mesospheric wind and temperature data from ALO. This event appeared to be long-lived but transient, with similar amplitude to the AO and SAO at this location. Additional mesospheric temperature data from nearby El Leoncito Observatory (31.8°S, 69.3°W), Argentina also showed the same oscillation. The existence and extent of this oscillation are being further examined using SABER/TIMED temperature. The National Center for Atmosphere Research (NCAR) Thermosphere-ionosphere-mesosphere-electrodynamics general circulation model (TIME-GCM) simulation of 2009/10 results are utilized to investigate the possible source of this event and the spatial structures are compared with the results from the SABER temperature data.

Getting It Right Matters: Climate Spectra and Their Estimation

NASA Astrophysics Data System (ADS)

Privalsky, Victor; Yushkov, Vladislav

2018-06-01

In many recent publications, climate spectra estimated with different methods from observed, GCM-simulated, and reconstructed time series contain many peaks at time scales from a few years to many decades and even centuries. However, respective spectral estimates obtained with the autoregressive (AR) and multitapering (MTM) methods showed that spectra of climate time series are smooth and contain no evidence of periodic or quasi-periodic behavior. Four order selection criteria for the autoregressive models were studied and proven sufficiently reliable for 25 time series of climate observations at individual locations or spatially averaged at local-to-global scales. As time series of climate observations are short, an alternative reliable nonparametric approach is Thomson's MTM. These results agree with both the earlier climate spectral analyses and the Markovian stochastic model of climate.

Quasi-biennial modulation of the Northern Hemisphere tropopause height and temperature

NASA Astrophysics Data System (ADS)

Ribera, P.; PeñA-Ortiz, C.; AñEl, J. A.; Gimeno, L.; de la Torre, L.; Gallego, D.

2008-04-01

The influence of the quasi-biennial oscillation (QBO) on the tropopause pressure and temperature is studied through the application of the multitaper-singular value decomposition method (MTM-SVD). Reanalysis data (ERA-40) from the European Centre for Medium-Range Weather Forecasts (ECMWF) and radiosonde data from the Integrated Global Radiosonde Archive (IGRA) covering the period 1979-1999 are used. The results show a strong response of the height and temperature of the tropopause to the QBO not limited to the equatorial latitudes but affecting the entire Northern Hemisphere. A cooling (warming) of the tropopause temperature over polar (equatorial) latitudes during a QBO positive phase is observed, being particularly noticeable over polar latitudes. The anomalies in the tropopause height confirm these results, with the tropopause being at higher (lower) levels in polar (equatorial) latitudes during QBO positive phase. Results for the QBO negative phase are of opposite sign. We also found that the results obtained using raw radiosonde data and reanalysis are in very good agreement. Finally, the evolution of the mass stream function through a QBO cycle is used to justify the differences observed in the evolution of the tropopause characteristics at low and high latitudes through the QBO cycle.

Disparity Implications of the Medicare MTM Eligibility Criteria: A Literature Review

PubMed Central

Munshi, Kiraat D.; Shih, Ya-Chen Tina; Brown, Lawrence M.; Dagogo-Jack, Samuel; Wan, Jim Y.; Wang, Junling

2013-01-01

Summary The emphasis on eliminating racial and ethnic disparities in health care has received national attention, with various policy initiatives addressing this problem and proposing solutions. However, in the current economic era requiring tight monetary constraints, emphasis is increasingly being placed on economic efficiency, which often conflicts with the equality doctrine upon which many policies have been framed. Our review aims to highlight the disparity implications of one such policy provision—the predominantly utilization-based eligibility criteria for medication therapy management (MTM) services under Medicare Part D—by identifying studies that have documented racial and ethnic disparities in health status and the use of and spending on prescription medications. Future design and evaluation of various regulations and legislations employing utilization-based eligibility criteria must use caution in order to strike an equity-efficiency balance. PMID:23570431

Geologic Mapping of MTM -30247, -35247 and -40247 Quadrangles, Reull Vallis Region, Mars

NASA Technical Reports Server (NTRS)

Mest, S. C.; Crown, D. A.

2009-01-01

Geologic mapping of MTM -30247, -35247, and -40247 quadrangles is being used to characterize Reull Vallis (RV) and to determine the history of the eastern Hellas region of Mars. Studies of RV examine the roles and timing of volatile-driven erosional and depositional processes and provide constraints on potential associated climatic changes. This study complements earlier investigations of the eastern Hellas region, including regional analyses [1-6], mapping studies of circum-Hellas canyons [7-10], and volcanic studies of Hadriaca and Tyrrhena Paterae [11-13]. Key scientific objectives include 1) characterizing RV in its "fluvial zone," 2) analysis of channels in the surrounding plains and potential connections to and interactions with RV, 3) examining young, presumably sedimentary plains along RV, and 4) determining the nature of the connection between the segments of RV.

Medication therapy management and complex patients with disability: a randomized controlled trial.

PubMed

Chrischilles, Elizabeth A; Doucette, William; Farris, Karen; Lindgren, Scott; Gryzlak, Brian; Rubenstein, Linda; Youland, Kelly; Wallace, Robert B

2014-02-01

Drug therapy problems, adverse drug events (ADEs), and symptom burden are high among adults with disabilities. To compare the effects of a modified medication therapy management (MTM) program within a self-efficacy workshop versus the workshop alone or usual care on symptom burden among adults with activity limitations. Three-group randomized controlled trial among adults (age 40 and older) with self-reported activity limitations in community practice. 8 weekly Living Well With a Disability (LWD) 2-hour workshop sessions with and without a collaborative medication management (CMM) module. mean number of moderate to very severe symptoms from a list of 11 physical and mental symptoms. Process measures: changes in medication regimens and self-reported ADEs. general linear mixed models (continuous outcomes) and generalized estimating equations (categorical outcomes). Participants had high symptom burden, low physical health, and took many medications. There was a significant increase in ADE reporting in the LWD + CMM group relative to the other 2 groups (Study group × Time P = .014), and there were significantly more changes in medication regimens in the LWD + CMM group (P = .013 LWD only vs LWD + CMM). The oldest third of participants had significantly fewer mean symptoms but received more intense CMM. There was no difference between the LWD-only, LWD + CMM, and usual care groups in symptom burden over time. Pharmacist MTM practices and MTM guidelines may need to be modified to affect symptom burden in a population with physical activity limitations.

Patient-centered health care using pharmacist-delivered medication therapy management in rural Mississippi.

PubMed

Ross, Leigh Ann; Bloodworth, Lauren S

2012-01-01

To describe and provide preliminary clinical and economic outcomes from a pharmacist-delivered patient-centered health care (PCHC) model implemented in the Mississippi Delta. Mississippi between July 2008 and June 2010. 13 community pharmacies in nine Mississippi Delta counties. This PCHC model implements a comprehensive medication therapy management (MTM) program with pharmacist training, individualized patient encounters and group education, provider outreach, integration of pharmacists into health information technology, and on-site support in community pharmacies in a medically underserved region with a large burden of chronic disease and health disparities. The program also expands on traditional MTM services through initiatives in health literacy/cultural competency and efforts to increase the provider network and improve access to care. Criteria-based clinical outcomes, quality indicator reports, cost avoidance. PCHC services have been implemented in 13 pharmacies in nine counties in this underserved region, and 78 pharmacists and 177 students have completed the American Pharmacists Association's MTM Certificate Training Program. Preliminary data from 468 patients showed 681 encounters in which 1,471 drug therapy problems were identified and resolved. Preliminary data for clinical indicators and economic outcome measures are trending in a positive direction. Preliminary data analyses suggest that pharmacist-provided PCHC is beneficial and has the potential to be replicated in similar rural communities that are plagued with chronic disease and traditional primary care provider shortages. This effort aligns with national priorities to reduce medication errors, improve health outcomes, and reduce health care costs in underserved communities.

Phosphatidylinositol 3-kinase inhibition restores Ca2+ release defects and prolongs survival in myotubularin-deficient mice

PubMed Central

Kutchukian, Candice; Lo Scrudato, Mirella; Tourneur, Yves; Poulard, Karine; Vignaud, Alban; Berthier, Christine; Allard, Bruno; Lawlor, Michael W.; Buj-Bello, Ana; Jacquemond, Vincent

2016-01-01

Mutations in the gene encoding the phosphoinositide 3-phosphatase myotubularin (MTM1) are responsible for a pediatric disease of skeletal muscle named myotubular myopathy (XLMTM). Muscle fibers from MTM1-deficient mice present defects in excitation–contraction (EC) coupling likely responsible for the disease-associated fatal muscle weakness. However, the mechanism leading to EC coupling failure remains unclear. During normal skeletal muscle EC coupling, transverse (t) tubule depolarization triggers sarcoplasmic reticulum (SR) Ca2+ release through ryanodine receptor channels gated by conformational coupling with the t-tubule voltage-sensing dihydropyridine receptors. We report that MTM1 deficiency is associated with a 60% depression of global SR Ca2+ release over the full range of voltage sensitivity of EC coupling. SR Ca2+ release in the diseased fibers is also slower than in normal fibers, or delayed following voltage activation, consistent with the contribution of Ca2+-gated ryanodine receptors to EC coupling. In addition, we found that SR Ca2+ release is spatially heterogeneous within myotubularin-deficient muscle fibers, with focally defective areas recapitulating the global alterations. Importantly, we found that pharmacological inhibition of phosphatidylinositol 3-kinase (PtdIns 3-kinase) activity rescues the Ca2+ release defects in isolated muscle fibers and increases the lifespan and mobility of XLMTM mice, providing proof of concept for the use of PtdIns 3-kinase inhibitors in myotubular myopathy and suggesting that unbalanced PtdIns 3-kinase activity plays a critical role in the pathological process. PMID:27911767

Methane emissions from a landfill in north-east India: Performance of various landfill gas emission models.

PubMed

Gollapalli, Muralidhar; Kota, Sri Harsha

2018-03-01

Rapid urbanization and economic growth has led to significant increase in municipal solid waste generation in India during the last few decades and its management has become a major issue because of poor waste management practices. Solid waste generated is deposited into open dumping sites with hardly any segregation and processing. Carbon dioxide (CO 2 ), methane (CH 4 ) and nitrous oxide (N 2 O) are the major greenhouse gases that are released from the landfill sites due to the biodegradation of organic matter. In this present study, CH 4 and CO 2 emissions from a landfill in north-east India are estimated using a flux chamber during September, 2015 to August, 2016. The average emission rates of CH 4 and CO 2 are 68 and 92 mg/min/m 2 , respectively. The emissions are highest in the summer whilst being lowest in winter. The diurnal variation of emissions indicated that the emissions follow a trend similar to temperature in all the seasons. Correlation coefficients of CH 4 and temperature in summer, monsoon and winter are 0.99, 0.87 and 0.97, respectively. The measured CH 4 in this study is in the range of other studies around the world. Modified Triangular Method (MTM), IPCC model and the USEPA Landfill gas emissions model (LandGEM) were used to predict the CH 4 emissions during the study year. The consequent simulation results indicate that the MTM, LandGEM-Clean Air Act, LandGEM-Inventory and IPCC models predict 1.9, 3.3, 1.6 and 1.4 times of the measured CH 4 emission flux in this study. Assuming that this higher prediction of CH 4 levels observed in this study holds well for other landfills in this region, a new CH 4 emission inventory (Units: Tonnes/year), with a resolution of 0.1 0  × 0.1 0 has been developed. This study stresses the importance of biodegradable composition of waste and meteorology, and also points out the drawbacks of the widely used landfill emission models. Copyright © 2017 Elsevier Ltd. All rights reserved.

Integration of remote blood glucose meter upload technology into a clinical pharmacist medication therapy management service.

PubMed

Schenk, Robert J; Schenk, Jenna

2011-01-01

A pharmacist-delivered, outpatient-focused medication therapy management (MTM) program is using a remote blood glucose (BG) meter upload device to provide better care and to improve outcomes for its patients with diabetes. Sharing uploaded BG meter data, presented in easily comprehensible graphs and charts, enables patients, caregivers, and the medical team to better understand how the patients' diabetes care is progressing. Pharmacists are becoming increasingly more active in helping to manage patients' complex medication regimens in an effort to help detect and avoid medication-related problems. Working together with patients and their physicians as part of an interdisciplinary health care team, pharmacists are helping to improve medication outcomes. This article focuses on two case studies highlighting the Diabetes Monitoring Program, one component of the Meridian Pharmacology Institute MTM service, and discusses the clinical application of a unique BG meter upload device. © 2010 Diabetes Technology Society.

Trajectory-based morphological operators: a model for efficient image processing.

PubMed

Jimeno-Morenilla, Antonio; Pujol, Francisco A; Molina-Carmona, Rafael; Sánchez-Romero, José L; Pujol, Mar

2014-01-01

Mathematical morphology has been an area of intensive research over the last few years. Although many remarkable advances have been achieved throughout these years, there is still a great interest in accelerating morphological operations in order for them to be implemented in real-time systems. In this work, we present a new model for computing mathematical morphology operations, the so-called morphological trajectory model (MTM), in which a morphological filter will be divided into a sequence of basic operations. Then, a trajectory-based morphological operation (such as dilation, and erosion) is defined as the set of points resulting from the ordered application of the instant basic operations. The MTM approach allows working with different structuring elements, such as disks, and from the experiments, it can be extracted that our method is independent of the structuring element size and can be easily applied to industrial systems and high-resolution images.

High-order rogue wave solutions of the classical massive Thirring model equations

NASA Astrophysics Data System (ADS)

Guo, Lijuan; Wang, Lihong; Cheng, Yi; He, Jingsong

2017-11-01

The nth-order solutions of the classical massive Thirring model (MTM) equations are derived by using the n-fold Darboux transformation. These solutions are expressed by the ratios of the two determinants consisted of 2n eigenfunctions under the reduction conditions. Using this method, rogue waves are constructed explicitly up to the third-order. Three patterns, i.e., fundamental, triangular and circular patterns, of the rogue waves are discussed. The parameter μ in the MTM model plays the role of the mass in the relativistic field theory while in optics it is related to the medium periodic constant, which also results in a significant rotation and a remarkable lengthening of the first-order rogue wave. These results provide new opportunities to observe rouge waves by using a combination of electromagnetically induced transparency and the Bragg scattering four-wave mixing because of large amplitudes.

Geologic Mapping of MTM -30247, -35247 and -40247 Quadrangles, Reull Vallis Region of Mars

NASA Technical Reports Server (NTRS)

Mest, S. C.; Crown, D. A.

2008-01-01

Geologic mapping and stratigraphic analyses of MTM -30247, -35247, and -40247 quadrangles are being used to characterize the Reull Vallis (RV) system and to determine the history of the eastern Hellas region of Mars. Studies of RV examine the roles and timing of volatile-driven erosional and depositional processes and provide constraints on potential associated climatic changes. This study complements earlier investigations of the eastern Hellas region, including regional analyses [1-6], mapping studies of circum-Hellas canyons [7-10], and volcanic studies of Hadriaca and Tyrrhena Paterae [11-13]. Key scientific objectives for these quadrangles include 1) characterization of RV in its "fluvial zone," 2) analysis of channels in the surrounding plains and potential connections to and interactions with RV, 3) examination of young (?), presumably sedimentary plains along RV that embay the surrounding highlands, and 4) determination of the nature of the connection between segments 1 and 2 of RV.

Evidence of spectrally broad Gravity Wave packet propagation and dispersion in the mesopause region observed by the Na lidar and Mesospheric Temperature Mapper above Logan, Utah

NASA Astrophysics Data System (ADS)

Yuan, T.; Heale, C. J.; Snively, J. B.

2016-12-01

Utilizing observations from the Na lidar at Utah State University and the nearby Mesospheric Temperature Mapper (MTM) at Bear Lake Observatory (BLO) [41.9°N, 111.4°W], we investigate a unique case of vertical dispersion for a spectrally broad gravity wave packet in the mesopause region over Logan, Utah (41.7°N, 111.8°W) that occurred on September 2nd, 2011, to study the waves' evolution as a packet propagates upward. The lidar observed temperature perturbation was dominated by close to a 1-hour modulation at 100 km during the early hours, but gradually evolved into a 1.5-hour modulation during the second half of the night. The vertical wavelength also decreased simultaneously, while the vertical group and phase velocities of the packet apparently slowed, as it was approaching a critical level during the second half of the night. A two-dimensional numerical model is utilized to simulate the observed GW processes, finding that the location of the lidar relative to the source can strongly influence which portion of the spectrum can be observed at a particular location relative to a source.

Epithelial self-healing is recapitulated by a 3D biomimetic E-cadherin junction.

PubMed

Cohen, Daniel J; Gloerich, Martijn; Nelson, W James

2016-12-20

Epithelial monolayers undergo self-healing when wounded. During healing, cells collectively migrate into the wound site, and the converging tissue fronts collide and form a stable interface. To heal, migrating tissues must form cell-cell adhesions and reorganize from the front-rear polarity characteristic of cell migration to the apical-basal polarity of an epithelium. However, identifying the "stop signal" that induces colliding tissues to cease migrating and heal remains an open question. Epithelial cells form integrin-based adhesions to the basal extracellular matrix (ECM) and E-cadherin-mediated cell-cell adhesions on the orthogonal, lateral surfaces between cells. Current biological tools have been unable to probe this multicellular 3D interface to determine the stop signal. We addressed this problem by developing a unique biointerface that mimicked the 3D organization of epithelial cell adhesions. This "minimal tissue mimic" (MTM) comprised a basal ECM substrate and a vertical surface coated with purified extracellular domain of E-cadherin, and was designed for collision with the healing edge of an epithelial monolayer. Three-dimensional imaging showed that adhesions formed between cells, and the E-cadherin-coated MTM resembled the morphology and dynamics of native epithelial cell-cell junctions and induced the same polarity transition that occurs during epithelial self-healing. These results indicate that E-cadherin presented in the proper 3D context constitutes a minimum essential stop signal to induce self-healing. That the Ecad:Fc MTM stably integrated into an epithelial tissue and reduced migration at the interface suggests that this biointerface is a complimentary approach to existing tissue-material interfaces.

Epithelial self-healing is recapitulated by a 3D biomimetic E-cadherin junction

PubMed Central

Cohen, Daniel J.; Gloerich, Martijn; Nelson, W. James

2016-01-01

Epithelial monolayers undergo self-healing when wounded. During healing, cells collectively migrate into the wound site, and the converging tissue fronts collide and form a stable interface. To heal, migrating tissues must form cell–cell adhesions and reorganize from the front-rear polarity characteristic of cell migration to the apical-basal polarity of an epithelium. However, identifying the "stop signal" that induces colliding tissues to cease migrating and heal remains an open question. Epithelial cells form integrin-based adhesions to the basal extracellular matrix (ECM) and E-cadherin–mediated cell–cell adhesions on the orthogonal, lateral surfaces between cells. Current biological tools have been unable to probe this multicellular 3D interface to determine the stop signal. We addressed this problem by developing a unique biointerface that mimicked the 3D organization of epithelial cell adhesions. This "minimal tissue mimic" (MTM) comprised a basal ECM substrate and a vertical surface coated with purified extracellular domain of E-cadherin, and was designed for collision with the healing edge of an epithelial monolayer. Three-dimensional imaging showed that adhesions formed between cells, and the E-cadherin-coated MTM resembled the morphology and dynamics of native epithelial cell–cell junctions and induced the same polarity transition that occurs during epithelial self-healing. These results indicate that E-cadherin presented in the proper 3D context constitutes a minimum essential stop signal to induce self-healing. That the Ecad:Fc MTM stably integrated into an epithelial tissue and reduced migration at the interface suggests that this biointerface is a complimentary approach to existing tissue–material interfaces. PMID:27930308

Cloning and characterization of an alternatively spliced gene in proximal Xq28 deleted in two patients with intersexual genitalia and myotubular myopathy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Laporte, J.; Hu, Ling-Jia; Kretz, C.

1997-05-01

We have identified a novel human gene that is entirely deleted in two boys with abnormal genital development and myotubular myopathy (MTM1). The gene, F18, is located in proximal Xq28, approximately 80 kb centromeric to the recently isolated MTM1 gene. Northern analysis of mRNA showed a ubiquitous pattern and suggested high levels of expression in skeletal muscle, brain, and heart. A transcript of 4.6 kb was detected in a range of tissues, and additional alternate forms of 3.8 and 2.6 kb were present in placenta and pancreas, respectively. The gene extends over 100 kb and is composed of at leastmore » seven exons, of which two are non-coding. Sequence analysis of a 4.6-kb cDNA contig revealed two overlapping open reading frames (ORFs) that encode putative proteins of 701 and 424 amino acids, respectively. Two alternative spliced transcripts affecting the large open reading frame were identified that, together with the Northern blot results, suggest that distinct proteins are derived from the gene. No significant homology to other known proteins was detected, but segments of the first ORF encode polyglutamine tracts and proline-rich domains, which are frequently observed in DNA-binding proteins. The F18 gene is a strong candidate for being implicated in the intersexual genitalia present in the two MTM1-deleted patients. The gene also serves as a candidate for other disorders that map to proximal Xq28. 15 refs., 3 figs., 1 tab.« less

REMOTE SENSING AND MOUNTAINTOP MINING

EPA Science Inventory

Coal mining is Appalachia has undergone dramatic changes in the past decade. Modem mining practices know as Mountaintop Mining (MTM) and Valley Fills (VF) are at the center of an environmental and legal controversy that has spawned lawsuits and major environmental investigations....

Evaluation of 3M(TM) Scotchlite linear delineation system : final report.

DOT National Transportation Integrated Search

2004-09-01

Major construction projects present many hazards for drivers to negotiate. Detours, lane shifts and confusing curves : present unique challenges to all drivers. At night, the difficulties in negotiating these obstacles are amplified due to : reduced ...

Investigations of Volcanic and Volatile-Driven Processes Northeast of Hellas Basin, Mars

NASA Astrophysics Data System (ADS)

Mest, S. C.; Crown, D. A.; Michalski, J.; Chuang, F. C.; Price Blount, K.; Bleamaster, L. F.

2018-06-01

We are mapping the geologic units and features in three MTM quadrangles northeast of Hellas basin at 1:1M scale. The area displays evidence for volcanism and widespread volatile-related modification of the surface.

White Sands Missile Range Non-Track Optics: Streamlining the Process of Conducting Business for Improved Customer Support

DTIC Science & Technology

2013-12-01

45 A. METHODOLOGY... 45 B. ANALYSIS .....................................................................................................46 C...digital airborne guidance section MFOM MLRS family of munitions MLRS Multiple Launch Rocket System MMW millimeter wave MT material test MTM

Geologic Map of the MTM -30262 and -30267 Quadrangles, Hadriaca Patera Region of Mars

USGS Publications Warehouse

Crown, David A.; Greeley, Ronald

2007-01-01

Introduction Mars Transverse Mercator (MTM) -30262 and -30267 quadrangles cover the summit region and east margin of Hadriaca Patera, one of the Martian volcanoes designated highland paterae. MTM -30262 quadrangle includes volcanic deposits from Hadriaca Patera and Tyrrhena Patera (summit northeast of map area) and floor deposits associated with the Dao and Niger Valles canyon systems (south of map area). MTM -30267 quadrangle is centered on the caldera of Hadriaca Patera. The highland paterae are among the oldest, central-vent volcanoes on Mars and exhibit evidence for explosive eruptions, which make a detailed study of their geology an important component in understanding the evolution of Martian volcanism. Photogeologic mapping at 1:500,000-scale from analysis of Viking Orbiter images complements volcanological studies of Hadriaca Patera, geologic investigations of the other highland paterae, and an analysis of the styles and evolution of volcanic activity east of Hellas Planitia in the ancient, cratered highlands of Mars. This photogeologic study is an extension of regional geologic mapping east of Hellas Planitia. The Martian highland paterae are low-relief, areally extensive volcanoes exhibiting central calderas and radial channels and ridges. Four of these volcanoes, Hadriaca, Tyrrhena, Amphitrites, and Peneus Paterae, are located in the ancient cratered terrains surrounding Hellas Planitia and are thought to be located on inferred impact basin rings or related fractures. Based on analyses of Mariner 9 images, Potter (1976), Peterson (1977), and King (1978) suggested that the highland paterae were shield volcanoes formed by eruptions of fluid lavas. Later studies noted morphologic similarities between the paterae and terrestrial ash shields and the lack of primary lava flow features on the flanks of the volcanoes. The degraded appearances of Hadriaca and Tyrrhena Paterae and the apparently easily eroded materials composing their low, broad shields further suggest that the highland paterae are composed predominantly of pyroclastic deposits. Analyses of eruption and flow processes indicate that the distribution of units at Hadriaca and Tyrrhena Paterae is consistent with emplacement by gravity-driven pyroclastic flows. Detailed geologic study of the summit caldera and flanks of Hadriaca Patera is essential to determine the types of volcanic materials exposed, the nature of the processes forming these deposits, and the role of volcanism in the evolution of the cratered highlands that are characteristic of the southern hemisphere of Mars.

Analysis of eddy currents induced by transverse and longitudinal gradient coils in different tungsten collimators geometries for SPECT/MRI integration.

PubMed

Samoudi, Amine M; Van Audenhaege, Karen; Vermeeren, Günter; Poole, Michael; Tanghe, Emmeric; Martens, Luc; Van Holen, Roel; Joseph, Wout

2015-12-01

We investigated the temporal variation of the induced magnetic field due to the transverse and the longitudinal gradient coils in tungsten collimators arranged in hexagonal and pentagonal geometries with and without gaps between the collimators. We modeled x-, y-, and z-gradient coils and different arrangements of single-photon emission computed tomography (SPECT) collimators using FEKO, a three-dimensional electromagnetic simulation tool. A time analysis approach was used to generate the pulsed magnetic field gradient. The approach was validated with measurements using a 7T MRI scanner. Simulations showed an induced magnetic field representing 4.66% and 0.87% of the applied gradient field (gradient strength = 500 mT/m) for longitudinal and transverse gradient coils, respectively. These values can be reduced by 75% by adding gaps between the collimators for the pentagonal arrangement, bringing the maximum induced magnetic field to less than 2% of the applied gradient for all of the gradient coils. Characterization of the maximum induced magnetic field shows that by adding gaps between the collimators for an integrated SPECT/MRI system, eddy currents can be corrected by the MRI system to avoid artifact. The numerical model was validated and was proposed as a tool for studying the effect of a SPECT collimator within the MRI gradient coils. © 2014 Wiley Periodicals, Inc.

Testing multi-theory model (MTM) in predicting initiation and sustenance of physical activity behavior among college students.

PubMed

Nahar, Vinayak K; Sharma, Manoj; Catalano, Hannah Priest; Ickes, Melinda J; Johnson, Paul; Ford, M Allison

2016-01-01

Most college students do not adequately participate in enough physical activity (PA) to attain health benefits. A theory-based approach is critical in developing effective interventions to promote PA. The purpose of this study was to examine the utility of the newly proposed multi-theory model (MTM) of health behavior change in predicting initiation and sustenance of PA among college students. Using a cross-sectional design, a valid and reliable survey was administered in October 2015 electronically to students enrolled at a large Southern US University. The internal consistency Cronbach alphas of the subscales were acceptable (0.65-0.92). Only those who did not engage in more than 150 minutes of moderate to vigorous intensity aerobic PA during the past week were included in this study. Of the 495 respondents, 190 met the inclusion criteria of which 141 completed the survey. The majority of participants were females (72.3%) and Caucasians (70.9%). Findings of the confirmatory factor analysis (CFA) confirmed construct validity of subscales (initiation model: χ2 = 253.92 [df = 143], P < 0.001, CFI = 0.91, RMSEA = 0.07, SRMR = 0.07; sustenance model: χ2= 19.40 [df = 22], P < 0.001, CFI = 1.00, RMSEA = 0.00, SRMR = 0.03). Multivariate regression analysis showed that 26% of the variance in the PA initiation was explained by advantages outweighing disadvantages, behavioral confidence, work status, and changes in physical environment. Additionally, 29.7% of the variance in PA sustenance was explained by emotional transformation, practice for change, and changes in social environment. Based on this study's findings, MTM appears to be a robust theoretical framework for predicting PA behavior change. Future research directions and development of suitable intervention strategies are discussed.

High power long pulse microwave generation from a metamaterial structure with reverse symmetry

NASA Astrophysics Data System (ADS)

Lu, Xueying; Stephens, Jacob C.; Mastovsky, Ivan; Shapiro, Michael A.; Temkin, Richard J.

2018-02-01

Experimental operation of a high power microwave source with a metamaterial (MTM) structure is reported at power levels to 2.9 MW at 2.4 GHz in full 1 μs pulses. The MTM structure is formed by a waveguide that is below cutoff for TM modes. The waveguide is loaded by two axial copper plates machined with complementary split ring resonators, allowing two backward wave modes to propagate in the S-Band. A pulsed electron beam of up to 490 kV, 84 A travels down the center of the waveguide, midway between the plates. The electron beam is generated by a Pierce gun and is focused by a lens into a solenoidal magnetic field. The MTM plates are mechanically identical but are placed in the waveguide with reverse symmetry. Theory indicates that both Cherenkov and Cherenkov-cyclotron beam-wave interactions can occur. High power microwave generation was studied by varying the operating parameters over a wide range, including the electron beam voltage, the lens magnetic field, and the solenoidal field. Frequency tuning with a magnetic field and beam voltage was studied to discriminate between operation in the Cherenkov mode and the Cherenkov-cyclotron mode. Both modes were observed, but pulses above 1 MW of output power were only seen in the Cherenkov-cyclotron mode. A pair of steering coils was installed prior to the interaction space to initiate the cyclotron motion of the electron beam and thus encourage the Cherenkov-cyclotron high power mode. This successfully increased the output power from 2.5 MW to 2.9 MW (450 kV, 74 A, 9% efficiency).

Atmospheric particulate matter in proximity to mountaintop coal mines: Sources and potential environmental and human health impacts

USGS Publications Warehouse

Kurth, Laura; Kolker, Allan; Engle, Mark A.; Geboy, Nicholas J.; Hendryx, Michael; Orem, William H.; McCawley, Michael; Crosby, Lynn M.; Tatu, Calin A.; Varonka, Matthew S.; DeVera, Christina A.

2015-01-01

Mountaintop removal mining (MTM) is a widely used approach to surface coal mining in the US Appalachian region whereby large volumes of coal overburden are excavated using explosives, removed, and transferred to nearby drainages below MTM operations. To investigate the air quality impact of MTM, the geochemical characteristics of atmospheric particulate matter (PM) from five surface mining sites in south central West Virginia, USA, and five in-state study control sites having only underground coal mining or no coal mining whatsoever were determined and compared. Epidemiologic studies show increased rates of cancer, respiratory disease, cardiovascular disease, and overall mortality in Appalachian surface mining areas compared to Appalachian non-mining areas. In the present study, 24-h coarse (>2.5 µm) and fine (≤2.5 µm) PM samples were collected from two surface mining sites in June 2011 showed pronounced enrichment in elements having a crustal affinity (Ga, Al, Ge, Rb, La, Ce) contributed by local sources, relative to controls. Follow-up sampling in August 2011 lacked this enrichment, suggesting that PM input from local sources is intermittent. Using passive samplers, dry deposition total PM elemental fluxes calculated for three surface mining sites over multi-day intervals between May and August 2012 were 5.8 ± 1.5 times higher for crustal elements than at controls. Scanning microscopy of 2,249 particles showed that primary aluminosilicate PM was prevalent at surface mining sites compared to secondary PM at controls. Additional testing is needed to establish any link between input of lithogenic PM and disease rates in the study area.

Testing multi-theory model (MTM) in predicting initiation and sustenance of physical activity behavior among college students

PubMed Central

Nahar, Vinayak K.; Sharma, Manoj; Catalano, Hannah Priest; Ickes, Melinda J.; Johnson, Paul; Ford, M. Allison

2016-01-01

Background: Most college students do not adequately participate in enough physical activity (PA) to attain health benefits. A theory-based approach is critical in developing effective interventions to promote PA. The purpose of this study was to examine the utility of the newly proposed multi-theory model (MTM) of health behavior change in predicting initiation and sustenance of PA among college students. Methods: Using a cross-sectional design, a valid and reliable survey was administered in October 2015 electronically to students enrolled at a large Southern US University. The internal consistency Cronbach alphas of the subscales were acceptable (0.65-0.92). Only those who did not engage in more than 150 minutes of moderate to vigorous intensity aerobic PA during the past week were included in this study. Results: Of the 495 respondents, 190 met the inclusion criteria of which 141 completed the survey. The majority of participants were females (72.3%) and Caucasians (70.9%). Findings of the confirmatory factor analysis (CFA) confirmed construct validity of subscales (initiation model: χ2 = 253.92 [df = 143], P < 0.001, CFI = 0.91, RMSEA = 0.07, SRMR = 0.07; sustenance model: χ2= 19.40 [df = 22], P < 0.001, CFI = 1.00, RMSEA = 0.00, SRMR = 0.03). Multivariate regression analysis showed that 26% of the variance in the PA initiation was explained by advantages outweighing disadvantages, behavioral confidence, work status, and changes in physical environment. Additionally, 29.7% of the variance in PA sustenance was explained by emotional transformation, practice for change, and changes in social environment. Conclusion: Based on this study’s findings, MTM appears to be a robust theoretical framework for predicting PA behavior change. Future research directions and development of suitable intervention strategies are discussed. PMID:27386419

Factors associated with independent pharmacy owners' satisfaction with Medicare Part D contracts.

PubMed

Zhang, Su; Doucette, William R; Urmie, Julie M; Xie, Yang; Brooks, John M

2010-06-01

As Medicare Part D contracts apply pressure on the profitability of independent pharmacies, there is concern about their owners' willingness to sign such contracts. Identifying factors affecting independent pharmacy owners' satisfaction with Medicare Part D contracts could inform policy makers in managing Medicare Part D. (1) To identify influences on independent pharmacy owners' satisfaction with Medicare Part D contracts and (2) to characterize comments made by independent pharmacy owners about Medicare Part D. This cross-sectional study used a mail survey of independent pharmacy owners in 15 states comprising 6 Medicare regions to collect information on their most- and least-favorable Medicare Part D contracts, including satisfaction, contract management activities, market position, pharmacy operation, and specific payment levels on brand and generic drugs. Of the 1649 surveys mailed, 296 surveys were analyzed. The regression models for satisfaction with both the least and the most-favorable Part D contracts were significant (P<0.05). A different set of significant influences on satisfaction was identified for each regression model. For the most-favorable contract, influences were contending and equity. For the least-favorable contract, influences were negotiation, equity, generic rate bonus, and medication therapy management (MTM) payment. About one-third of the survey respondents made at least 1 comment. The most frequent themes in the comments were that Medicare Part D reimbursement rate is too low (28%) and that contracts are offered without negotiation in a "take it or leave it" manner (20%). Equity, contending, negotiation, generic rate bonus, and MTM payments were identified as the influences of independent pharmacy owners' satisfaction toward Medicare Part D contracts. Generic rate bonus and MTM payment provide additional financial incentives to less financially favorable contracts and, in turn, contribute to independent pharmacy owner's satisfaction toward these contracts. Copyright 2010 Elsevier Inc. All rights reserved.

Traditional lecture versus jigsaw learning method for teaching Medication Therapy Management (MTM) core elements.

PubMed

Wilson, Jennifer A; Pegram, Angela H; Battise, Dawn M; Robinson, April M

2017-11-01

To determine if traditional didactic lecture or the jigsaw learning method is more effective to teach the medication therapy management (MTM) core elements in a first year pharmacy course. Traditional didactic lecture and a pre-class reading assignment were used in the fall semester cohort, and the jigsaw method was used in the spring semester cohort. Jigsaw is a cooperative learning strategy requiring students to assume responsibility for learning, and subsequently teaching peers. The students were responsible for reading specific sections of the pre-class reading, and then teaching other students in small groups about their specific reading assignments. To assess potential differences, identical pre- and post-tests were administered before and after the MTM section. Additionally, grade performance on an in-class project and final exam questions were compared, and students were surveyed on perceptions of teaching method used. A total of 45 and 43 students completed both the pre- and post-test in the fall and spring (96% and 93% response rate), respectively. Improvement in post-test scores favored the traditional method (p = 0.001). No statistical differences were noted between groups with grade performance on the in-class project and final exam questions. However, students favored the jigsaw method over traditional lecture and perceived improvements in problem solving skills, listening/communication skills and encouragement of cooperative learning (p = 0.018, 0.025 and 0.031). Although students favored the jigsaw learning method, traditional didactic lecture was more effective for the pre- and post-knowledge test performance. This may indicate that traditional didactic lecture is more effective for more foundational content. Copyright © 2017 Elsevier Inc. All rights reserved.

Atmospheric particulate matter in proximity to mountaintop coal mines: sources and potential environmental and human health impacts.

PubMed

Kurth, Laura; Kolker, Allan; Engle, Mark; Geboy, Nicholas; Hendryx, Michael; Orem, William; McCawley, Michael; Crosby, Lynn; Tatu, Calin; Varonka, Matthew; DeVera, Christina

2015-06-01

Mountaintop removal mining (MTM) is a widely used approach to surface coal mining in the US Appalachian region whereby large volumes of coal overburden are excavated using explosives, removed, and transferred to nearby drainages below MTM operations. To investigate the air quality impact of MTM, the geochemical characteristics of atmospheric particulate matter (PM) from five surface mining sites in south central West Virginia, USA, and five in-state study control sites having only underground coal mining or no coal mining whatsoever were determined and compared. Epidemiologic studies show increased rates of cancer, respiratory disease, cardiovascular disease, and overall mortality in Appalachian surface mining areas compared to Appalachian non-mining areas. In the present study, 24-h coarse (>2.5 µm) and fine (≤2.5 µm) PM samples were collected from two surface mining sites in June 2011 showed pronounced enrichment in elements having a crustal affinity (Ga, Al, Ge, Rb, La, Ce) contributed by local sources, relative to controls. Follow-up sampling in August 2011 lacked this enrichment, suggesting that PM input from local sources is intermittent. Using passive samplers, dry deposition total PM elemental fluxes calculated for three surface mining sites over multi-day intervals between May and August 2012 were 5.8 ± 1.5 times higher for crustal elements than at controls. Scanning microscopy of 2,249 particles showed that primary aluminosilicate PM was prevalent at surface mining sites compared to secondary PM at controls. Additional testing is needed to establish any link between input of lithogenic PM and disease rates in the study area.

Midnight latitude-altitude distribution of 630 nm airglow in the Asian sector measured with FORMOSAT-2/ISUAL

NASA Astrophysics Data System (ADS)

Adachi, Toru; Yamaoka, Masashi; Yamamoto, Mamoru; Otsuka, Yuichi; Liu, Huixin; Hsiao, Chun-Chieh; Chen, Alfred B.; Hsu, Rue-Ron

2010-09-01

The Imager for Sprites and Upper Atmospheric Lightning (ISUAL) payload on board the FORMOSAT-2 satellite carried out the first limb imaging observation of 630 nm airglow for the purpose of studying physical processes in the F region ionosphere. For a total of 14 nights in 2006-2008, ISUAL scanned the midnight latitude-altitude distribution of 630 nm airglow in the Asian sector. On two nights of relatively active conditions (ΣKp = 26, 30+) we found several bright airglow regions, which were highly variable each night in terms of luminosity and location. In relatively quiet conditions (ΣKp = 4-20) near May/June we found two bright regions which were stably located in the midlatitude region of 40°S-10°S (50°S-20°S magnetic latitude (MLAT)) and in the equatorial region of 0°-10°N (10°S-0° MLAT). On one of the quiet nights, FORMOSAT-3/COSMIC and CHAMP simultaneously measured the plasma density in the same region where ISUAL observed airglow. The plasma density data generally show good agreement, suggesting that plasma enhancements were the primary source of these two bright airglow regions. From detailed comparison with past studies we explain that the airglow in the equatorial region was due to the midnight brightness wave produced in association with the midnight temperature maximum, while that in the midlatitude region was due to the typical plasma distribution usually formed in the midnight sector. The fact that the equatorial airglow was much brighter than the midlatitude airglow and was observed on most nights during the campaign period strongly suggests the importance of further studies on the MTM/MBW phenomenology, which is not well reproduced in the current general circulation model.

Nonlinear Dynamics, Poor Data, and What to Make of Them?

NASA Astrophysics Data System (ADS)

Ghil, M.; Zaliapin, I. V.

2005-12-01

The analysis of univariate or multivariate time series provides crucial information to describe, understand, and predict variability in the geosciences. The discovery and implementation of a number of novel methods for extracting useful information from time series has recently revitalized this classical field of study. Considerable progress has also been made in interpreting the information so obtained in terms of dynamical systems theory. In this talk we will describe the connections between time series analysis and nonlinear dynamics, discuss signal-to-noise enhancement, and present some of the novel methods for spectral analysis. These fall into two broad categories: (i) methods that try to ferret out regularities of the time series; and (ii) methods aimed at describing the characteristics of irregular processes. The former include singular-spectrum analysis (SSA), the multi-taper method (MTM), and the maximum-entropy method (MEM). The various steps, as well as the advantages and disadvantages of these methods, will be illustrated by their application to several important climatic time series, such as the Southern Oscillation Index (SOI), paleoclimatic time series, and instrumental temperature time series. The SOI index captures major features of interannual climate variability and is used extensively in its prediction. The other time series cover interdecadal and millennial time scales. The second category includes the calculation of fractional dimension, leading Lyapunov exponents, and Hurst exponents. More recently, multi-trend analysis (MTA), binary-decomposition analysis (BDA), and related methods have attempted to describe the structure of time series that include both regular and irregular components. Within the time available, I will try to give a feeling for how these methods work, and how well.

Imprint of the Atlantic Multidecadal Oscillation on Tree-Ring Widths in Northeastern Asia since 1568

PubMed Central

Wang, Xiaochun; Brown, Peter M.; Zhang, Yanni; Song, Laiping

2011-01-01

We present a new tree-ring reconstruction of the Atlantic Multidecadal Oscillation (AMO) spanning 1568–2007 CE from northeast Asia. Comparison of the instrumental AMO index, an existing tree-ring based AMO reconstruction, and this new record show strongly similar annual to multidecadal patterns of variation over the last 440 years. Warm phases of the AMO are related to increases in growth of Scots pine trees and moisture availability in northeast China and central eastern Siberia. Multi-tape method (MTM) and cross-wavelet analyses indicate that robust multidecadal (∼64–128 years) variability is present throughout the new proxy record. Our results have important implications concerning the influence of North Atlantic sea surface temperatures on East Asian climate, and provide support for the possibility of an AMO signature on global multidecadal climate variability. PMID:21818380

76 FR 37372 - Notice of Proposed Withdrawal Extension and Notification of a Public Meeting; Montana

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-27

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [61510-8451-0000; MTM 80092] Notice of Proposed Withdrawal Extension and Notification of a Public Meeting; Montana AGENCY: Bureau of Land...; 8:45 am] BILLING CODE 4310-55-P ...

Oriented clay nanopaper from biobased components--mechanisms for superior fire protection properties.

PubMed

Carosio, F; Kochumalayil, J; Cuttica, F; Camino, G; Berglund, L

2015-03-18

The toxicity of the most efficient fire retardant additives is a major problem for polymeric materials. Cellulose nanofiber (CNF)/clay nanocomposites, with unique brick-and-mortar structure and prepared by simple filtration, are characterized from the morphological point of view by scanning electron microscopy and X-ray diffraction. These nanocomposites have superior fire protection properties to other clay nanocomposites and fiber composites. The corresponding mechanisms are evaluated in terms of flammability (reaction to a flame) and cone calorimetry (exposure to heat flux). These two tests provide a wide spectrum characterization of fire protection properties in CNF/montmorrilonite (MTM) materials. The morphology of the collected residues after flammability testing is investigated. In addition, thermal and thermo-oxidative stability are evaluated by thermogravimetric analyses performed in inert (nitrogen) and oxidative (air) atmospheres. Physical and chemical mechanisms are identified and related to the unique nanostructure and its low thermal conductivity, high gas barrier properties and CNF/MTM interactions for char formation.

Broadbanding of circularly polarized patch antenna by waveguided magneto-dielectric metamaterial

NASA Astrophysics Data System (ADS)

Yang, Xin Mi; Wen, Juan; Liu, Chang Rong; Liu, Xue Guan; Cui, Tie Jun

2015-12-01

Design of bandwidth-enhanced circularly polarized (CP) patch antenna using artificial magneto-dielectric substrate was investigated. The artificial magneto-dielectric material adopted here takes the form of waveguided metamaterial (WG-MTM). In particular, the embedded meander line (EML) structure was employed as the building element of the WG-MTM. As verified by the retrieved effective medium parameters, the EML-based waveguided magneto-dielectric metamaterial (WG-MDM) exhibits two-dimensionally isotropic magneto-dielectric property with respect to TEM wave excitations applied in two orthogonal directions. A CP patch antenna loaded with the EML-based WG-MDM (WG-MDM antenna) has been proposed and its design procedure is described in detail. Simulation results show that the impedance and axial ratio bandwidths of the WG-MDM antenna have increased by 125% and 133%, respectively, compared with those obtained with pure dielectric substrate offering the same patch size. The design of the novel WG-MDM antenna was also validated by measurement results, which show good agreement with their simulated counterparts.

Statistical Analyses of Raw Material Data for MTM45-1/CF7442A-36% RW: CMH Cure Cycle

NASA Technical Reports Server (NTRS)

Coroneos, Rula; Pai, Shantaram, S.; Murthy, Pappu

2013-01-01

This report describes statistical characterization of physical properties of the composite material system MTM45-1/CF7442A, which has been tested and is currently being considered for use on spacecraft structures. This composite system is made of 6K plain weave graphite fibers in a highly toughened resin system. This report summarizes the distribution types and statistical details of the tests and the conditions for the experimental data generated. These distributions will be used in multivariate regression analyses to help determine material and design allowables for similar material systems and to establish a procedure for other material systems. Additionally, these distributions will be used in future probabilistic analyses of spacecraft structures. The specific properties that are characterized are the ultimate strength, modulus, and Poisson??s ratio by using a commercially available statistical package. Results are displayed using graphical and semigraphical methods and are included in the accompanying appendixes.

VizieR Online Data Catalog: MV Lyr - bursts and periods (Pavlenko, 1998)

NASA Astrophysics Data System (ADS)

Pavlenko, E. P.

2001-01-01

The analysis of photometric behavior of the nova-like star MV Lyr in B in the low brightness state in 1995-1996 based on the observations performed at the Crimean Astrophysical Observatory with the MTM-500 television system was presented. (1 data file).

Implementation and Clinical Outcomes of an Employer-Sponsored, Pharmacist-Provided Medication Therapy Management Program.

PubMed

Theising, Katie M; Fritschle, Traci L; Scholfield, Angelina M; Hicks, Emily L; Schymik, Michelle L

2015-11-01

Our objective was to describe the implementation and clinical outcomes of an employer-sponsored, pharmacist-provided medication therapy management (MTM) program for health plan beneficiaries with diabetes mellitus and/or hypertension. We conducted a single-center retrospective medical record review. The setting was a Pharmacy MTM Clinic at a self-insured health system consisting of six hospitals and several ancillary facilities. A total of 161 health plan beneficiaries with diabetes identified during annual wellness screenings for the health plan in 2012 and 225 health plan beneficiaries with diabetes and/or hypertension identified during annual wellness screenings for the health plan in 2013 were referred to the MTM clinic based on specific criteria. In 2012 the health system expanded its existing wellness program by implementing a voluntary diabetes care program for health plan beneficiaries with uncontrolled diabetes (hemoglobin A(1c) [A1C] 7% or higher); a similar program was added for hypertension for the 2013 plan year. All participants' A1C and blood pressure results were tracked from the date of their wellness screening through the end of the plan year. The pharmacists involved had the capability to directly implement drug regimen changes according to hospital protocol or provide recommendations to the physician, as specified by the referring physician. For the 2012-2013 plan year, the mean difference in A1C from baseline to program completion was -0.38% (95% confidence interval [CI] -0.58 to -0.18%, p<0.05). For beneficiaries with a baseline A1C of 7% or higher, the mean difference was -0.69% (95% CI -0.99 to -0.39%, p<0.05). For the 2013-2014 plan year, the mean difference in A1C from baseline to program completion was -0.62% (95% CI -0.81 to -0.44%, p<0.05). In that year, the mean difference in A1C for beneficiaries with A1C 7% or higher was -0.97% (95% CI -1.23 to -0.72%, p<0.05). For those referred for hypertension, a mean difference of -13 mm Hg (95% CI -18.59 to -7.73, p<0.05) from baseline to program completion was seen in systolic blood pressure, and the mean difference in diastolic blood pressure was -7 mm Hg (95% CI -9.92 to -4.04, p<0.05). This study demonstrated that health plan beneficiaries who participated in the employer-sponsored, pharmacist-provided MTM program had significant decreases in A1C and blood pressure. © 2015 Pharmacotherapy Publications, Inc.

Becoming a Leader: Finding My Voice

ERIC Educational Resources Information Center

Finchum, Tabetha R.

2014-01-01

In this article, fourth-grade teacher Tabetha Finchum describes how a program called Arizona Master Teacher of Mathematics (AZ-MTM), a Noyce grant funded through the National Science Foundation, helped boost her confidence and broaden her understanding of the philosophies, curricula, and instructional decisions being implemented by other teachers.…

Geologic Mapping of Athabasca Valles

NASA Technical Reports Server (NTRS)

Keszthelyi, L. P.; Jaeger, W. L.; Tanaka, K.; Hare, T.

2009-01-01

We are approaching the end of the third year of mapping the Athabasca Valles region of Mars. The linework has been adjusted in response to new CTX images and we are on schedule to submit the 4 MTM quads (05202, 05207, 10202, 10207) and ac-companying paper by the end of this fiscal year.

75 FR 59741 - Notice of Proposed Withdrawal and Opportunity for Public Meeting; Montana

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-28

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLMTB072000-L14300000-ET0000; MTM 98499] Notice of Proposed Withdrawal and Opportunity for Public Meeting; Montana AGENCY: Bureau of Land.... [FR Doc. 2010-24281 Filed 9-27-10; 8:45 am] BILLING CODE 4310-$$-P ...

75 FR 63856 - Public Land Order No. 7753; Extension of Public Land Order No. 7464; Montana

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-18

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLMTL06000-L14300000.ET0000; MTM 89170] Public Land Order No. 7753; Extension of Public Land Order No. 7464; Montana AGENCY: Bureau of Land...:45 am] BILLING CODE 4310-DN-P ...

77 FR 53226 - Public Land Order No. 7792; Partial Revocation, Power Site Reserve No. 109; Montana

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-31

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [MT-LLB05000-LL14300000-FQ0000; MTM 40412] Public Land Order No. 7792; Partial Revocation, Power Site Reserve No. 109; Montana Correction In notice...:45 am] BILLING CODE 1505-01-D ...

Efficacy of Two Mathematics Interventions for Enhancing Fluency with Elementary Students

ERIC Educational Resources Information Center

Mong, Michael D.; Mong, Kristi W.

2010-01-01

An alternating treatments design was used to evaluate two curriculum-based mathematics interventions designed to enhance fluency with three elementary school students. Results indicate that both the Math to Mastery (MTM) intervention and the Cover, Copy, Compare (CCC) intervention were effective at increasing mathematics fluency, as measured by…

75 FR 15456 - Notice of Availability for the Signal Peak Energy, LLC, Federal Coal Lease Application...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-29

... James M. Sparks, Manager, Billings Field Office, 5001 Southgate Drive, Billings, Montana 59101-4669... CONTACT: Craig Drake, Assistant Manager, Billings Field Office, 5001 Southgate Drive, Billings, Montana... Application MTM 97988. DATES: The public hearing will be held in the BLM Montana State Office's main...

The Effects of Mountaintop Mines and Valley Fills on Aquatic Ecosystems of the Central Appalachian Coalfields (External Review Draft)

EPA Science Inventory

This report assesses the state of the science on the environmental impacts of mountaintop mines and valley fills (MTM-VF) on streams in the Central Appalachian Coalfields. Our review focused on the aquatic impacts of mountaintop removal coal mining, which, as its name suggests, ...

75 FR 18499 - The Effects of Mountaintop Mines and Valley Fills on Aquatic Ecosystems of the Central...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-12

... environmental permitting requirements for Appalachian mountaintop removal and other surface coal mining projects.../guidance/mining.html ). Both documents will be reviewed by an independent review panel convened by EPA's... the state of the science on the ecological impacts of Mountaintop Mining and Valley Fill (MTM-VF...

Mountaintop mining consequences

Treesearch

M.A. Palmer; E.S. Bernhardt; W.H. Schlesinger; K.N. Eshleman; E. Foufoula-Georgiou; M.S. Hendryx; A.D. Lemly; G.E. Likens; O.L. Loucks; M.E. Power; P.S. White; P.R. Wilcock

2010-01-01

There has been a global, 30-year increase in surface mining (1), which is now the dominant driver of land-use change in the central Appalachian ecoregion of the United States (2). One major form of such mining, mountaintop mining with valley fills (MTM/VF) (3), is widespread throughout eastern Kentucky, West Virginia (WV), and southwestern Virginia. Upper elevation...

76 FR 9358 - Notice of Proposed Withdrawal Extension and Opportunity for Public Meeting; Montana

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-17

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [MTM 067221] Notice of Proposed Withdrawal Extension and Opportunity for Public Meeting; Montana AGENCY: Bureau of Land Management, Interior. ACTION.... Cynthia Staszak, Chief, Branch of Land Resources. [FR Doc. 2011-3617 Filed 2-16-11; 8:45 am] BILLING CODE...

Multiple Signal Classification for Determining Direction of Arrival of Frequency Hopping Spread Spectrum Signals

DTIC Science & Technology

2014-03-27

42 4.2.3 Number of Hops Hs . . . . . . . . . . . . . . . . . . . . . . . . . 45 4.2.4 Number of Sensors M... 45 4.5 Standard deviation vs. Ns. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46 4.6 Bias...laboratory MTM multiple taper method MUSIC multiple signal classification MVDR minimum variance distortionless reposnse PSK phase shift keying QAM

Trained student pharmacists' telephonic collection of patient medication information: Evaluation of a structured interview tool.

PubMed

Margolis, Amanda R; Martin, Beth A; Mott, David A

2016-01-01

To determine the feasibility and fidelity of student pharmacists collecting patient medication list information using a structured interview tool and the accuracy of documenting the information. The medication lists were used by a community pharmacist to provide a targeted medication therapy management (MTM) intervention. Descriptive analysis of patient medication lists collected with telephone interviews. Ten trained student pharmacists collected the medication lists. Trained student pharmacists conducted audio-recorded telephone interviews with 80 English-speaking, community-dwelling older adults using a structured interview tool to collect and document medication lists. Feasibility was measured using the number of completed interviews, the time student pharmacists took to collect the information, and pharmacist feedback. Fidelity to the interview tool was measured by assessing student pharmacists' adherence to asking all scripted questions and probes. Accuracy was measured by comparing the audio-recorded interviews to the medication list information documented in an electronic medical record. On average, it took student pharmacists 26.7 minutes to collect the medication lists. The community pharmacist said the medication lists were complete and that having the medication lists saved time and allowed him to focus on assessment, recommendations, and education during the targeted MTM session. Fidelity was high, with an overall proportion of asked scripted probes of 83.75% (95% confidence interval [CI], 80.62-86.88%). Accuracy was also high for both prescription (95.1%; 95% CI, 94.3-95.8%) and nonprescription (90.5%; 95% CI, 89.4-91.4%) medications. Trained student pharmacists were able to use an interview tool to collect and document medication lists with a high degree of fidelity and accuracy. This study suggests that student pharmacists or trained technicians may be able to collect patient medication lists to facilitate MTM sessions in the community pharmacy setting. Evaluating the sustainability of using student pharmacists or trained technicians to collect medication lists is needed. Copyright © 2016 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Trained student pharmacists’ telephonic collection of patient medication information: Evaluation of a structured interview tool

PubMed Central

Margolis, Amanda R.; Martin, Beth A.; Mott, David A.

2016-01-01

Objective To determine the feasibility and fidelity of student pharmacists collecting patient medication list information using a structured interview tool and the accuracy of documenting the information. The medication lists were used by a community pharmacist to provide a targeted medication therapy management (MTM) intervention. Design Descriptive analysis of patient medication lists collected via telephone interviews. Participants 10 trained student pharmacists collected the medication lists. Intervention Trained student pharmacists conducted audio-recorded telephone interviews with 80 English-speaking community dwelling older adults using a structured interview tool to collect and document medication lists. Main outcome measures Feasibility was measured using the number of completed interviews, the time student pharmacists took to collect the information, and pharmacist feedback. Fidelity to the interview tool was measured by assessing student pharmacists’ adherence to asking all scripted questions and probes. Accuracy was measured by comparing the audio recorded interviews to the medication list information documented in an electronic medical record. Results On average it took student pharmacists 26.7 minutes to collect the medication lists. The community pharmacist said the medication lists were complete and that having the medication lists saved time and allowed him to focus on assessment, recommendations, and education during the targeted MTM session. Fidelity was high with an overall proportion of asked scripted probes of 83.75% (95%CI: 80.62–86.88%). Accuracy was also high for both prescription (95.1%, 95%CI: 94.3–95.8%) and non-prescription (90.5%, 95%CI: 89.4–91.4%) medications. Conclusion Trained student pharmacists were able to use an interview tool to collect and document medication lists with a high degree of fidelity and accuracy. This study suggests that student pharmacists or trained technicians may be able to collect patient medication lists to facilitate MTM sessions in the community pharmacy setting. Evaluating the sustainability of using student pharmacists or trained technicians to collect medication lists is needed. PMID:27000165

Geologic map of the MTM 85200 quadrangle, Olympia Rupes region of Mars

USGS Publications Warehouse

Skinner, James A.; Herkenhoff, Kenneth E.

2012-01-01

The north polar region of Mars is dominated by Planum Boreum, a roughly circular, domical plateau that rises >2,500 m above the surrounding lowland. Planum Boreum is >1,500 km in diameter, contains deep, curvilinear troughs and chasmata, isolated cavi, and marginal scarps and slopes. The north polar plateau is surrounded by low-lying and nearly horizontal plains of various surface texture, geologic origin, and stratigraphic significance. The MTM 85200 quadrangle spans 5° of latitude (lat 82.5° to 87.5° N.) and 40° of longitude (long 140° to 180° E.) within the eastern hemisphere of Mars. The quadrangle includes the high-standing Planum Boreum, curvilinear troughs of Boreales Scopuli, deep, sinuous scarps of Olympia Rupes, isolated and coalesced depressions of Olympia Cavi, margins of the circular polar erg Olympia Undae, and low-standing Olympia Planum. The surface of Planum Boreum within the MTM 85200 quadrangle is characterized by smoothly sculptured landforms with shallow slopes and variable relief at kilometer scales. Areas that are perennially covered with bright frost are generally smooth and planar at 100-m scales. However, MGS MOC and MRO HiRISE images show that much of the icy polar plateau is rough at decameter scale. The Martian polar plateaus are likely to contain a record of global climate history for >107 to as much as ~3 x 109 years. This record is partly observable as rhythmically layered deposits exposed in the curvilinear troughs of the north polar plateau, Planum Boreum. The north polar layered deposits are widely interpreted to be among the most youthful bedrock deposits on the Martian surface. These materials and their stratigraphic and structural relations provide a glimpse into some of the more recent geologic processes that have occurred on Mars. The ability of the massive polar deposits to periodically trap and release both volatiles and lithic particles may represent a globally important, recurring geologic process for Mars.

Improving the economic and humanistic outcomes for diabetic patients: making a case for employer-sponsored medication therapy management

PubMed Central

Pinto, Sharrel L; Kumar, Jinender; Partha, Gautam; Bechtol, Robert A

2013-01-01

Background The purpose of this study was to determine the cost savings of a pharmacist-led, employer-sponsored medication therapy management (MTM) program for diabetic patients and to assess for any changes in patient satisfaction and self-reported medication adherence for enrollees. Methods Participants in this study were enrollees of an employer-sponsored MTM program. They were included if their primary medical insurance and prescription coverage was from the City of Toledo, they had a diagnosis of type 2 diabetes, and whether or not they had been on medication or had been given a new prescription for diabetes treatment. The data were analyzed on a prospective, pre-post longitudinal basis, and tracked for one year following enrollment. Outcomes included economic costs, patient satisfaction, and self-reported patient adherence. Descriptive statistics were used to characterize the population, calculate the number of visits, and determine the mean costs for each visit. Friedman’s test was used to determine changes in outcomes due to the nonparametric nature of the data. Results The mean number of visits to a physician’s office decreased from 10.22 to 7.07. The mean cost of these visits for patients increased from $47.70 to $66.41, but use of the emergency room and inpatient visits decreased by at least 50%. Employer spending on emergency room visits decreased by $24,214.17 and inpatient visit costs decreased by $166,610.84. Office visit spending increased by $11,776.41. A total cost savings of $179,047.80 was realized by the employer at the end of the program. Significant improvements in patient satisfaction and adherence were observed. Conclusion Pharmacist interventions provided through the employer-sponsored MTM program led to substantial cost savings to the employer with improved patient satisfaction and adherence on the part of employees at the conclusion of the program. PMID:23610526

Automatic identification of resting state networks: an extended version of multiple template-matching

NASA Astrophysics Data System (ADS)

Guaje, Javier; Molina, Juan; Rudas, Jorge; Demertzi, Athena; Heine, Lizette; Tshibanda, Luaba; Soddu, Andrea; Laureys, Steven; Gómez, Francisco

2015-12-01

Functional magnetic resonance imaging in resting state (fMRI-RS) constitutes an informative protocol to investigate several pathological and pharmacological conditions. A common approach to study this data source is through the analysis of changes in the so called resting state networks (RSNs). These networks correspond to well-defined functional entities that have been associated to different low and high brain order functions. RSNs may be characterized by using Independent Component Analysis (ICA). ICA provides a decomposition of the fMRI-RS signal into sources of brain activity, but it lacks of information about the nature of the signal, i.e., if the source is artifactual or not. Recently, a multiple template-matching (MTM) approach was proposed to automatically recognize RSNs in a set of Independent Components (ICs). This method provides valuable information to assess subjects at individual level. Nevertheless, it lacks of a mechanism to quantify how much certainty there is about the existence/absence of each network. This information may be important for the assessment of patients with severely damaged brains, in which RSNs may be greatly affected as a result of the pathological condition. In this work we propose a set of changes to the original MTM that improves the RSNs recognition task and also extends the functionality of the method. The key points of this improvement is a standardization strategy and a modification of method's constraints that adds flexibility to the approach. Additionally, we also introduce an analysis to the trustworthiness measurement of each RSN obtained by using template-matching approach. This analysis consists of a thresholding strategy applied over the computed Goodness-of-Fit (GOF) between the set of templates and the ICs. The proposed method was validated on 2 two independent studies (Baltimore, 23 healthy subjects and Liege, 27 healthy subjects) with different configurations of MTM. Results suggest that the method will provide complementary information for characterization of RSNs at individual level.

Temperature and humidity dependent performance of FBG-strain sensors embedded in carbon/epoxy composites

NASA Astrophysics Data System (ADS)

Frövel, Malte; Carrión, Gabriel; Gutiérrez, César; Moravec, Carolina; Pintado, José María

2009-03-01

Fiber Bragg Grating Sensors, FBGSs, are very promising for Structural Health Monitoring, SHM, of aerospace vehicles due to their capacity to measure strain and temperature, their lightweight harnesses, their multiplexing capacities and their immunity to electromagnetic interferences, within others. They can be embedded in composite materials that are increasingly forming an important part of aerospace structures. The use of embedded FBGSs for SHM purposes is advantageous, but their response under all operative environmental conditions of an aerospace structure must be well understood for the necessary flight certification of these sensors. This paper describes the first steps ahead for a possible in future flight certification of FBGSs embedded in carbon fiber reinforced plastics, CFRP. The investigation work was focused on the validation of the dependence of the FBGS's strain sensitivity in tensile and compression load, in dry and humid condition and in a temperature range from -150°C to 120°C. The test conditions try to simulate the in service temperature and humidity range and static load condition of military aircraft. FBGSs with acrylic and with polyimide coating have been tested. The FBGSs are embedded in both, unidirectional and quasi isotropic carbon/epoxy composite material namely M21/T800 and also MTM-45-1/IM7. Conventional extensometers and strain gages have been used as reference strain sensors. The performed tests show an influence of the testing temperatures, the dry or wet specimen condition, the load direction and the coating material on the sensor strain sensitivity that should be taken into account when using these sensors.

76 FR 31977 - Public Land Order No. 7768; Extension of Public Land Order No. 6861; Montana

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-02

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLMTB01000-L14300000.ET0000; MTM 79264] Public Land Order No. 7768; Extension of Public Land Order No. 6861; Montana AGENCY: Bureau of Land... and Minerals Management. [FR Doc. 2011-13720 Filed 6-1-11; 8:45 am] BILLING CODE P ...

76 FR 41516 - Notice of Proposed Withdrawal Extension and Notification of a Public Meeting; Montana; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-14

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [61510-8451-0000; MTM 80092] Notice of Proposed Withdrawal Extension and Notification of a Public Meeting; Montana; Correction AGENCY: Bureau of... Staszak, Chief, Branch of Land Resources. [FR Doc. 2011-17716 Filed 7-13-11; 8:45 am] BILLING CODE 4310-55...

77 FR 60458 - Public Land Order No. 7803; Withdrawal of Public Lands for the Limestone Hills Training Area; MT

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-03

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLMTB072000-L14300000-ET0000; MTM 98499] Public Land Order No. 7803; Withdrawal of Public Lands for the Limestone Hills Training Area; MT AGENCY... Filed 10-2-12; 8:45 am] BILLING CODE 1430-DN-P ...

75 FR 55604 - Notice of Proposed Withdrawal Extension and Opportunity for Public Meeting; Montana

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-13

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLMTM01000-L14300000.ET0000; MTM 79264] Notice of Proposed Withdrawal Extension and Opportunity for Public Meeting; Montana AGENCY: Bureau of... Miller, Acting Chief, Branch of Land Resources. [FR Doc. 2010-22740 Filed 9-10-10; 8:45 am] BILLING CODE...

75 FR 6702 - Notice of Correction to Notice of Realty Action; Application for Recordable Disclaimer of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-10

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLMT924000-L14300000.FR0000; MTM 99415] Notice of Correction to Notice of Realty Action; Application for Recordable Disclaimer of Interest... ``disclaimer''. Cindy Staszak, Chief, Branch of Land Resources. [FR Doc. 2010-2851 Filed 2-9-10; 8:45 am...

78 FR 35957 - Public Land Order No. 7815; Extension of Public Land Order No. 6997; Montana

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-14

... DEPARTMENT OF THE INTERIOR Bureau of Land Management [61510-8451-0000; MTM 80092] Public Land Order No. 7815; Extension of Public Land Order No. 6997; Montana AGENCY: Bureau of Land Management.... Suh, Assistant Secretary--Policy, Management and Budget. [FR Doc. 2013-14115 Filed 6-13-13; 8:45 am...

METHYLATION OF ARSENIC BY RECOMBINANT HUMAN AS3MT/287M AND AS3MT/287T POLYMORPHS

EPA Science Inventory

Arsenic (+3 oxidation state) methyltransferase (AS3MT) is the key enzyme in the pathway for methylation of inorganic arsenic (iAs). AS3MT polymorphism is, in part, responsible for interindividual differences in iAs metabolism. AS3MT/M287T polymorphism that is found in ~ 10% of C...

Evaluation of FFTF fuel pin design procedure vis-a-vis steady state irradiation performance in EBR II

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jackson, R.J.

1976-11-01

The FFTF fuel pin design analysis is shown to be conservative through comparison with pin irradiation experience in EBR-II. This comparison shows that the actual lifetimes of EBR-II fuel pins are either greater than 80,000 MWd/MTM or greater than the calculated allowable lifetimes based on thermal creep strain.

77 FR 46111 - Public Land Order No. 7792; Partial Revocation, Power Site Reserve No. 109; Montana

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-02

... DEPARTMENT OF THE INTERIOR Bureau of land management [MT-LLB05000-LL14300000-FQ0000; MTM 40412] Public Land Order No. 7792; Partial Revocation, Power Site Reserve No. 109; Montana AGENCY: Bureau of...--Policy, Management and Budget. [FR Doc. 2012-18888 Filed 8-1-12; 8:45 am] BILLING CODE 4310-DN-P ...

Geologic Map of the Olympia Cavi Region of Mars (MTM 85200): A Summary of Tactical Approaches

NASA Technical Reports Server (NTRS)

Skinner, J. A., Jr.; Herkenhoff, K.

2010-01-01

The 1:500K-scale geologic map of MTM 85200 - the Olympia Cavi region of Mars - has been submitted for peer review [1]. Physiographically, the quadrangle includes portions of Olympia Rupes, a set of sinuous scarps which elevate Planum Boreum 800 meters above Olympia Planum. The region includes the high-standing, spiral troughs of Boreales Scopuli, the rugged and deep depressions of Olympia Cavi, and the vast dune fields of Olympia Undae. Geologically, the mapped units and landforms reflect the recent history of repeated accumulation and degradation. The widespread occurrence of both weakly and strongly stratified units implicates the drape-like accumulation of ice, dust, and sand through climatic variations. Similarly, the occurrence of layer truncations, particularly at unit boundaries, implicates punctuated periods of both localized and regional erosion and surface deflation whereby underlying units were exhumed and their material transported and re-deposited. Herein, we focus on the iterative mapping approaches that allowed not only the accommodation of the burgeoning variety and volume of data sets, but also facilitated the efficient presentation of map information. Unit characteristics and their geologic history are detailed in past abstracts [2-3].

Reduction of the spatially mutual coupling between dual-polarized patch antennas using coupled metamaterial slabs.

PubMed

Pan, Bai Cao; Tang, Wen Xuan; Qi, Mei Qing; Ma, Hui Feng; Tao, Zui; Cui, Tie Jun

2016-07-22

Mutual coupling inside antenna array is usually caused by two routes: signal leakage via conducting currents on the metallic background or surface wave along substrates; radio leakage received from space between antenna elements. The former one can be depressed by changing the distribution of surface currents, as reported in literatures. But when it comes to the latter one, the radiation-leakage-caused coupling, traditional approaches using circuit manipulation may be inefficient. In this article, we propose and design a new type of decoupling module, which is composed of coupled metamaterial (MTM) slabs. Two classes of MTM particles, the interdigital structure (IS) and the split-ring resonators (SRRs), are adopted to provide the first and second modulations of signal. We validate its function to reduce the radiation leakage between two dual-polarized patch antennas. A prototype is fabricated in a volume with subwavelength scale (0.6λ × 0.3λ × 0.053λ) to provide 7dB improvement for both co-polarization and cross-polarization isolations from 1.95 to 2.2 GHz. The design has good potential for wireless communication and radar systems.

Reduction of the spatially mutual coupling between dual-polarized patch antennas using coupled metamaterial slabs

PubMed Central

Pan, Bai Cao; Tang, Wen Xuan; Qi, Mei Qing; Ma, Hui Feng; Tao, Zui; Cui, Tie Jun

2016-01-01

Mutual coupling inside antenna array is usually caused by two routes: signal leakage via conducting currents on the metallic background or surface wave along substrates; radio leakage received from space between antenna elements. The former one can be depressed by changing the distribution of surface currents, as reported in literatures. But when it comes to the latter one, the radiation-leakage-caused coupling, traditional approaches using circuit manipulation may be inefficient. In this article, we propose and design a new type of decoupling module, which is composed of coupled metamaterial (MTM) slabs. Two classes of MTM particles, the interdigital structure (IS) and the split-ring resonators (SRRs), are adopted to provide the first and second modulations of signal. We validate its function to reduce the radiation leakage between two dual-polarized patch antennas. A prototype is fabricated in a volume with subwavelength scale (0.6λ × 0.3λ × 0.053λ) to provide 7dB improvement for both co-polarization and cross-polarization isolations from 1.95 to 2.2 GHz. The design has good potential for wireless communication and radar systems. PMID:27444147

Methylation of Arsenic by Recombinant Human Wild-Type Arsenic (+3 Oxidation State) Methyltransferase and its Methionine 287 Threonine (M287T) Polymorph

EPA Science Inventory

ABSTRACT Arsenic (+3 oxidation state) methyltransferase (AS3MT) is the key enzyme in the pathway for methylation of arsenicals. A common polymorphism in the AS3MT gene that replaces a threonyl residue in position 287 with a methionyl residue (AS3MT/M287T) occurs at a frequency...

Geologic Mapping in Southern Margaritifer Terra

NASA Technical Reports Server (NTRS)

Irwin, R. P., III; Grant, J. A.

2010-01-01

Margaritifer Terra records a complex geologic history [1-5], and the area from Holden crater through Ladon Valles, Ladon basin, and up to Morava Valles is no exception [e.g., 6-13]. The 1:500,000 geologic map of MTM quadrangles -15027, -20027, -25027, and -25032 (Figs. 1 and 2 [14]) identifies a range of units that delineate the history of water-related activity and regional geologic context.

75 FR 41237 - Public Land Order No. 7745; Partial Revocation of Power Site Reserve Nos. 510 and No. 515; Montana

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-15

... MTM 41534] Public Land Order No. 7745; Partial Revocation of Power Site Reserve Nos. 510 and No. 515... of public lands withdrawn for Power Site Reserve Nos. 510 and 515. This order also opens the lands to... INFORMATION: The Bureau of Land Management has determined that portions of Power Site Reserve Nos. 510 and 515...

Point-vortex stability under the influence of an external periodic flow

NASA Astrophysics Data System (ADS)

Ortega, Rafael; Ortega, Víctor; Torres, Pedro J.

2018-05-01

We provide sufficient conditions for the stability of the particle advection around a fixed vortex in a two-dimensional ideal fluid under the action of a periodic background flow. The proof relies on the identification of closed invariant curves around the origin by means of Moser’s invariant curve theorem. Partially supported by Spanish MINECO and ERDF project MTM2014-52232-P.

CASK and CaMKII function in the mushroom body α'/β' neurons during Drosophila memory formation.

PubMed

Malik, Bilal R; Gillespie, John Michael; Hodge, James J L

2013-01-01

Ca(2+)/CaM serine/threonine kinase II (CaMKII) is a central molecule in mechanisms of synaptic plasticity and memory. A vital feature of CaMKII in plasticity is its ability to switch to a calcium (Ca(2+)) independent constitutively active state after autophosphorylation at threonine 287 (T287). A second pair of sites, T306 T307 in the calmodulin (CaM) binding region once autophosphorylated, prevent subsequent CaM binding and inactivates the kinase during synaptic plasticity and memory. Recently a synaptic molecule called Ca(2+)/CaM-dependent serine protein kinase (CASK) has been shown to control both sets of CaMKII autophosphorylation events and hence is well poised to be a key regulator of memory. We show deletion of full length CASK or just its CaMK-like and L27 domains disrupts middle-term memory (MTM) and long-term memory (LTM), with CASK function in the α'/β' subset of mushroom body neurons being required for memory. Likewise directly changing the levels of CaMKII autophosphorylation in these neurons removed MTM and LTM. The requirement of CASK and CaMKII autophosphorylation was not developmental as their manipulation just in the adult α'/β' neurons was sufficient to remove memory. Overexpression of CASK or CaMKII in the α'/β' neurons also occluded MTM and LTM. Overexpression of either Drosophila or human CASK in the α'/β' neurons of the CASK mutant completely rescued memory, confirming that CASK signaling in α'/β' neurons is necessary and sufficient for Drosophila memory formation and that the neuronal function of CASK is conserved between Drosophila and human. At the cellular level CaMKII overexpression in the α'/β' neurons increased activity dependent Ca(2+) responses while reduction of CaMKII decreased it. Likewise reducing CASK or directly expressing a phosphomimetic CaMKII T287D transgene in the α'/β' similarly decreased Ca(2+) signaling. Our results are consistent with CASK regulating CaMKII autophosphorylation in a pathway required for memory formation that involves activity dependent changes in Ca(2+) signaling in the α'/β' neurons.

Protective effects of Rutin against methanol induced acute toxic optic neuropathy: an experimental study.

PubMed

Taşlı, Nurdan Gamze; Çimen, Ferda Keskin; Karakurt, Yücel; Uçak, Turgay; Mammadov, Renad; Süleyman, Bahadır; Kurt, Nezahat; Süleyman, Halis

2018-01-01

To determine the effects of Rutin on methanol induced optic neuropathy and compare the results with the effects of ethanol. Totally 30 rats were divided into 5 groups, with 6 rats in each group as follows: healthy controls (C), methotrexate (MTX), methotrexate+methanol (MTM), methotrexate+methanol+ethanol (MTME) and methotrexate+ methanol+Rutin (MTMR). In all rabbits except those of the control group, MTX, diluted in sterile serum physiologic, 0.3 mg/kg per oral was applied for 7d by the aid of a tube. After this procedure to the rats of MTM, MTME and MTMR groups, 20% methanol with a dose of 3 g/kg per oral was given by the aid of a tube. In MTME group, 4h after the application of methanol, 20% ethanol was applied by the same way with a dose of 0.5 g/kg. On the other hand, in MTMR group 4h after the application of methanol, Rutin, which was dissolved in distilled water, was applied by the same way with a dose of 50 mg/kg. There were statistically significant differences in tissue 8-hydroxy-2 deoxyguanine (8-OHdG), interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α), malondialdehyde (MDA), myeloperoxidase (MPO). glutathione peroxidase (tGSH) and superoxide dismutase (SOD) levels between groups ( P <0.001). In MTMR group tissue 8-OHdG, IL-1β, MDA, and MPO levels were similar with the healthy controls but significantly different than the other groups. In histopathological evaluations, in MTX group there was moderate focal destruction, hemorrhage and decrease in number of astrocytes and oligodendrocytes; in MTM group there was severe destruction and edema with decrease in number of astrocytes and oligodendrocytes; in MTME group there was mild hemorrhage, mild edema, mildly dilated blood vessels with congestion while in MTMR group, optic nerve tissue was resembling the healthy controls. Rutin may prevent methanol-induced optic neuropathy via anti-inflammatory effects and decreasing the oxidative stress. New treatment options are warranted in this disease to avoid loss of vision in patients.

TU-F-CAMPUS-I-04: Head-Only Asymmetric Gradient System Evaluation: ACR Image Quality and Acoustic Noise

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weavers, P; Shu, Y; Tao, S

Purpose: A high-performance head-only magnetic resonance imaging gradient system with an acquisition volume of 26 cm employing an asymmetric design for the transverse coils has been developed. It is able to reach a magnitude of 85 mT/m at a slew rate of 700 T/m/s, but operated at 80 mT/m and 500 T/m/s for this test. A challenge resulting from this asymmetric design is that the gradient nonlinearly exhibits both odd- and even-ordered terms, and as the full imaging field of view is often used, the nonlinearity is pronounced. The purpose of this work is to show the system can producemore » clinically useful images after an on-site gradient nonlinearity calibration and correction, and show that acoustic noise levels fall within non-significant risk (NSR) limits for standard clinical pulse sequences. Methods: The head-only gradient system was inserted into a standard 3T wide-bore scanner without acoustic damping. The ACR phantom was scanned in an 8-channel receive-only head coil and the standard American College of Radiology (ACR) MRI quality control (QC) test was performed. Acoustic noise levels were measured for several standard pulse sequences. Results: Images acquired with the head-only gradient system passed all ACR MR image quality tests; Both even and odd-order gradient distortion correction terms were required for the asymmetric gradients to pass. Acoustic noise measurements were within FDA NSR guidelines of 99 dBA (with assumed 20 dBA hearing protection) A-weighted and 140 dB for peak for all but one sequence. Note the gradient system was installed without any shroud or acoustic batting. We expect final system integration to greatly reduce noise experienced by the patient. Conclusion: A high-performance head-only asymmetric gradient system operating at 80 mT/m and 500 T/m/s conforms to FDA acoustic noise limits in all but one case, and passes all the ACR MR image quality control tests. This work was supported in part by the NIH grant 5R01EB010065.« less

Temperature initiated passive cooling system

DOEpatents

Forsberg, Charles W.

1994-01-01

A passive cooling system for cooling an enclosure only when the enclosure temperature exceeds a maximum standby temperature comprises a passive heat transfer loop containing heat transfer fluid having a particular thermodynamic critical point temperature just above the maximum standby temperature. An upper portion of the heat transfer loop is insulated to prevent two phase operation below the maximum standby temperature.

Topographic map of the Coronae Montes region of Mars - MTM 500k -35/087E OMKTT

USGS Publications Warehouse

Rosiek, Mark R.; Redding, Bonnie L.; Galuszca, Donna M.

2005-01-01

This map is part of a series of topographic maps of areas of special scientific interest on Mars. The topography was compiled photogrammetrically using Viking Orbiter stereo image pairs. The contour interval is 250 m. Horizontal and vertical control was established using the USGS Mars Digital Image Model 2.0 (MDIM 2.0) and data from the Mars Orbiter Laser Altimeter (MOLA).

Methods Engineering Workshop for the Shipbuilding Industry

DTIC Science & Technology

1985-09-01

physiological process that reduces the performance capacity and motivation of humans sub- jected to excessive or repeated work stresses. fatigue allowance, Time...often involves basic business fundamentals, motivation , common sense, and the plain hard work of one person doing something. But the accomplishment that...utilize a batch mode form. ” (3) SERGE A. BIRN HAS A TRAINING SCHOOL IN CINCINNATI FOR MTM, MSD, MCD, MOTIVATION -PRODUCTIVITY , TIME STUDY, METHODS

Topographic Map of the Northeast Ascraeus Mons Region of Mars - MTM 500k 15/257E OMKT

USGS Publications Warehouse

,

2004-01-01

This map is part of a series of topographic maps of areas of special scientific interest on Mars. The topography was compiled photogrammetically using Viking Orbiter stereo image pairs. The contour interval is 250 meters. Horizontal and vertical control was established using the USGS Mars Digital Image Model 2.0 (MDIM 2.0) and data from the Mars Orbiter Laser Altimeter (MOLA).

Topographic Map of the Northwest Ascraeus Mons Region of Mars - MTM 500k 15/252E OMKT

USGS Publications Warehouse

,

2004-01-01

This map is part of a series of topographic maps of areas of special scientific interest on Mars. The topography was compiled photogrammetically using Viking Orbiter stereo image pairs. The contour interval is 250 meters. Horizontal and vertical control was established using the USGS Mars Digital Image Model 2.0 (MDIM 2.0) and data from the Mars Orbiter Laser Altimeter (MOLA).

Topographic Map of the Southeast Ascraeus Mons Region of Mars - MTM 500k 10/257E OMKT

USGS Publications Warehouse

,

2004-01-01

This map is part of a series of topographic maps of areas of special scientific interest on Mars. The topography was compiled photogrammetically using Viking Orbiter stereo image pairs. The contour interval is 250 meters. Horizontal and vertical control was established using the USGS Mars Digital Image Model 2.0 (MDIM 2.0) and data from the Mars Orbiter Laser Altimeter (MOLA).

Topographic Map of the Southwest Ascraeus Mons Region of Mars - MTM 500k 10/252E OMKT

USGS Publications Warehouse

,

2004-01-01

This map is part of a series of topographic maps of areas of special scientific interest on Mars. The topography was compiled photogrammetically using Viking Orbiter stereo image pairs. The contour interval is 250 meters. Horizontal and vertical control was established using the USGS Mars Digital Image Model 2.0 (MDIM 2.0) and data from the Mars Orbiter Laser Altimeter (MOLA).

Cyclic Nucleotide-Gated Channels, Calmodulin, Adenylyl Cyclase, and Calcium/Calmodulin-Dependent Protein Kinase II Are Required for Late, but Not Early, Long-Term Memory Formation in the Honeybee

ERIC Educational Resources Information Center

Matsumoto, Yukihisa; Sandoz, Jean-Christophe; Devaud, Jean-Marc; Lormant, Flore; Mizunami, Makoto; Giurfa, Martin

2014-01-01

Memory is a dynamic process that allows encoding, storage, and retrieval of information acquired through individual experience. In the honeybee "Apis mellifera," olfactory conditioning of the proboscis extension response (PER) has shown that besides short-term memory (STM) and mid-term memory (MTM), two phases of long-term memory (LTM)…

Satisfaction With Medication Therapy Management Services at a University Ambulatory Care Clinic.

PubMed

Kim, Shiyun; Martin, Michelle T; Pierce, Andrea L; Zueger, Patrick

2016-06-01

A survey was issued to patients enrolled in the Medication Therapy Management Clinic (MTMC) at University of Illinois Hospital and Health Sciences (June 2011-January 2012) in order to assess satisfaction with pharmacy services provided by pharmacists. A 23-item survey was offered to 65 patients in the MTMC program before or after clinic visits. Since there is a paucity of data indicating the level of satisfaction with MTM services provided by pharmacists, this survey may contribute to the process of building a greater collaboration between the pharmacist and patient. Sixty-two of 65 patients completed the survey; satisfaction with MTMC pharmacists was demonstrated to be significantly positively correlated with overall satisfaction with the MTMC. Patient satisfaction is not significantly different according to age, gender, ethnicity, or number of disease states. Satisfaction with the pillbox service is not significantly different between younger and older patients. It was also noted that patients taking a greater number of medications had higher levels of satisfaction. Most patients indicated that they were satisfied with the MTMC pharmacists and services; further study linking patient satisfaction with MTM services to improved patient outcomes may allow our MTMC to serve as a model for other pharmacist-managed MTMCs serving similar patient populations. © The Author(s) 2014.

Geologic map of MTM -15027, -20027, -25027, and -25032 quadrangles, Margaritifer Terra region of Mars

USGS Publications Warehouse

Irwin, Rossman P.; Grant, John A.

2013-01-01

Mars Transverse Mercator (MTM) quadrangles −15027, −20027, −25027, and −25032 (lat 12.5°−28° S., long 330°−335° E. and lat 22.5°−28° S., long 324.5°−330° E.) in southwestern Margaritifer Terra include diverse erosional landforms, sedimentary deposits, and tectonic structures that record a long geologic and geomorphic history. The northeastern regional slope of the pre-Noachian crustal dichotomy (as expressed along the Chryse trough) and structures of the informally named Middle Noachian or older Holden and Ladon impact basins dominate the topography of the map area. A series of mesoscale outflow channels, Uzboi, Ladon, and Morava Valles, integrated these formerly enclosed basins by overflow and incision around the Noachian/Hesperian transition, although some flooding may have occurred earlier. The area includes excellent examples of Late Noachian to Hesperian valley networks, dissected crater rims, alluvial fans, deltas, and light-toned layered deposits, particularly in Holden and Eberswalde craters. Structural forms include Tharsis-radial grabens, Hesperian wrinkle ridges, floor-fractured impact craters, and severely disrupted chaotic terrains. These well-preserved landforms and sedimentary deposits represent multiple erosional epochs and discrete flooding events, which provide significant insight into the geomorphic processes and climate change on early Mars.

Large-scale, thick, self-assembled, nacre-mimetic brick-walls as fire barrier coatings on textiles

NASA Astrophysics Data System (ADS)

Das, Paramita; Thomas, Helga; Moeller, Martin; Walther, Andreas

2017-01-01

Highly loaded polymer/clay nanocomposites with layered structures are emerging as robust fire retardant surface coatings. However, time-intensive sequential deposition processes, e.g. layer-by-layer strategies, hinders obtaining large coating thicknesses and complicates an implementation into existing technologies. Here, we demonstrate a single-step, water-borne approach to prepare thick, self-assembling, hybrid fire barrier coatings of sodium carboxymethyl cellulose (CMC)/montmorillonite (MTM) with well-defined, bioinspired brick-wall nanostructure, and showcase their application on textile. The coating thickness on the textile is tailored using different concentrations of CMC/MTM (1-5 wt%) in the coating bath. While lower concentrations impart conformal coatings of fibers, thicker continuous coatings are obtained on the textile surface from highest concentration. Comprehensive fire barrier and fire retardancy tests elucidate the increasing fire barrier and retardancy properties with increasing coating thickness. The materials are free of halogen and heavy metal atoms, and are sourced from sustainable and partly even renewable building blocks. We further introduce an amphiphobic surface modification on the coating to impart oil and water repellency, as well as self-cleaning features. Hence, our study presents a generic, environmentally friendly, scalable, and one-pot coating approach that can be introduced into existing technologies to prepare bioinspired, thick, fire barrier nanocomposite coatings on diverse surfaces.

Adverse Climatic Conditions and Impact on Construction Scheduling and Cost

DTIC Science & Technology

1988-01-01

ABBREVIATIONS ABS MAX MAX TEMP ...... Absolute maximum maximum temperature ABS MIN MIN TEMP ...... Absolute minimum minimum temperature BTU...o Degrees Farenheit MEAN MAX TEMP o.................... Mean maximum temperature MEAN MIN TEMP...temperatures available, a determination had to be made as to whether forecasts were based on absolute , mean, or statistically derived temperatures

Temperature initiated passive cooling system

DOEpatents

Forsberg, C.W.

1994-11-01

A passive cooling system for cooling an enclosure only when the enclosure temperature exceeds a maximum standby temperature comprises a passive heat transfer loop containing heat transfer fluid having a particular thermodynamic critical point temperature just above the maximum standby temperature. An upper portion of the heat transfer loop is insulated to prevent two phase operation below the maximum standby temperature. 1 fig.

Magnetic Resonance Imaging of the anal canal using high resolution sequences and phased array coil: visualization of anal sphincter complex.

PubMed

Laghi, A; Iafrate, F; Paolantonio, P; Iannaccone, R; Baeli, I; Ferrari, R; Catalano, C; Passariello, R

2002-04-01

To assess the normal anatomy of the anal sphincter complex using high-resolution MR imaging with phased -array coil. Twenty patients, 13 males and 7 females, ranging in age between 27 and 56 years underwent MRI evaluation of the pelvic region, using a superconductive 1.5 T magnet (maximum gradient strength, 25 mT/m; minimum rise time 600 microseconds, equipped with phased-array coil. High-resolution T2-weighted Turbo Spin Echo sequences (TR, 4055 ms; TE, 132 ms; matrix 390x512; in-plane resolution, 0.67x0.57 mm) were acquired on multiple axial, sagittal and coronal planes. Images were reviewed by two experienced gastrointestinal radiologists in order to evaluate the normal anal sphincter complex. Optimal image quality of the anal sphincter complex was obtained in all cases. Different muscular layers were observed between the upper and lower aspects of the anal canal. In the lower part of the anal canal, internal and external sphincter muscles could be observed; in the upper part, puborectal and internal sphincter muscles were depicted. Good visualization of intersphincteric space, levator ani muscle and ischioanal space was also obtained in all cases. High-resolution MR images with phased-array coil provide optimal depiction of the anal canal and the anal sphincter complex.

Comprehensive Medication Reviews in Long-term Care Facilities: History of Process Implementation and 2015 Results.

PubMed

O'Shea, Terrence E; Zarowitz, Barbara J; Erwin, W Gary

2017-01-01

Since 2013, Part D sponsors have been required to offer comprehensive medication reviews (CMRs) to all beneficiaries enrolled in their medication therapy management (MTM) programs at least annually, including those in long-term care (LTC) settings. Since that time, MTM providers have found that accessing and completing CMRs with beneficiaries is frequently prohibitively complex, since the process often requires a live, face-to-face interactive interview where the beneficiary resides. However, with the migration of the CMR completion rate from a star ratings display measure to an active measure, coupled with the new CMR completion rate cutpoints for 2016, accessing this population for CMR completion has heightened importance. Our proprietary consultant pharmacist (CP) software was programmed in 2012 to produce a cover letter, medication action plan, and personal medication list per CMS standardized format specifications. Using this system, CPs were trained to perform and document CMRs and the interactive interviews. MTM-eligible Part D beneficiaries, identified by several contracted clients as residing in LTC serviced by Omnicare, were provided CMRs and summaries written in CMS standardized format by CPs. Residents with cognitive impairment were identified using 3 data elements in the Minimum Data Set (MDS). In 2015, 7,935 MTM-eligible beneficiaries were identified as receiving medications from an Omnicare pharmacy. After excluding those who were disenrolled by their prescription drug plans, discharged from the LTC facility, or resided in a LTC facility no longer serviced by Omnicare, 5,593 residents were available for CMR completion. Of these, only 3% refused the CMR offer, and 5,392 CMRs (96%) were completed successfully. Thirty-nine percent of residents had cognitive impairment per MDS assessments; in those instances, CMRs were conducted with someone other than the beneficiary. Based on the CMRs and interactive interviews, 7,527 drug therapy problem recommendations were made to prescribers, about 50% of which resulted in an alteration in therapy, including reductions in polypharmacy and high-risk medications. The CMR process and written summary in CMS standardized format works effectively for residents in LTC when performed by CPs in the facility, as evidenced by high completion rates and drug therapy problem identification/resolution. Part D plans should further consider using CPs to conduct CMRs in LTC settings. No outside funding supported this research. All authors are employees of Omnicare, a CVS Health Company, and are stockholders of CVS Health. O'Shea and Zarowitz have received research funding (unrelated to the submitted work) from Acadia, AstraZeneca, and Sunovion. The abstract for this article was presented as a research poster at the Academy of Managed Care and Specialty Pharmacy 2016 Annual Meeting; April 21, 2016; San Francisco, California. Study concept and design were contributed by O'Shea and Zarowitz, along with Erwin. O'Shea collected the data, and data interpretation was performed primarily by O'Shea, along with Zarowitz and Erwin. The manuscript was written by O'Shea, along with Zarowitz, and revised primarily by Zarowitz, along with O'Shea and Erwin.

E2 Cargo Transport--The Necessary Inclusion of Primary Oceanic Airlift

DTIC Science & Technology

2013-06-01

Energy Initiatives (L: Lead-; F: Follow-; W: Watch- Industry ) (Maybury, 2010:6...at the same time halting all supplies—including coal, food and fresh milk—which were drawn from the Soviet Sector…There was no longer any doubt...which consists of 223 C-17s and 111 C- 5s , provides a capacity of 35.9 million ton-miles per day (MTM/D). The peak for MCRS Case 1, which

Universal Zero Specular Reflection Curves for MetaMaterials

DTIC Science & Technology

2012-09-01

with their handedness, RH or LH. r   5 According to Holloway [7], we find that metasurfaces (or metafilms) can be used in place of MTMs in many...applications. Metafilm refers to thin metamaterial that is only one unit-cell thick. “ Metasurfaces have the advantage of taking up less physical space...than do full three-dimensional MTM structures.” [7] Further studies were conducted on metasurface characterization, various applications, and how

NATO Mobilization and Reinforcement: Can We Get There from Here?

DTIC Science & Technology

1990-05-30

of the USSR," Military Power , 1986, p . 93. 27. Pettavino. Paul J., Ibid. p . 1. 28. Carlucci, Frank C ., Ibid, p . 29. 29. Rowden. William H., Ibid, p ...mobility objectives (requirements) for the European theater: o Sixty-six million ton-miles-per-day (MTM/ D ) of cargo airlift. 25 o Sealift for one...Aircraft In Mili- tary Use," Independent Review of Economic, Political and Military Power , VOL. 33, Dec 88.

Evaluation of Ultra High Pressure (UHP) Firefighting in a Room-and-Contents Fire

DTIC Science & Technology

2017-03-15

Burn Room and Hangar Temperature Prior to Ignition ............................................... 18 Figure 12. Effect of Temperature on Normalized...Figure 20. Maximum Average Temperature and Heat Flux ......................................................... 22 Figure 21. Effect of Maximum Average...Aspirated Ceiling Temperature .................................... 23 Figure 22. Effect of Maximum Average Floor Heat Flux on Extinguishment Quantity

Towards bridging the gap between climate change projections and maize producers in South Africa

NASA Astrophysics Data System (ADS)

Landman, Willem A.; Engelbrecht, Francois; Hewitson, Bruce; Malherbe, Johan; van der Merwe, Jacobus

2018-05-01

Multi-decadal regional projections of future climate change are introduced into a linear statistical model in order to produce an ensemble of austral mid-summer maximum temperature simulations for southern Africa. The statistical model uses atmospheric thickness fields from a high-resolution (0.5° × 0.5°) reanalysis-forced simulation as predictors in order to develop a linear recalibration model which represents the relationship between atmospheric thickness fields and gridded maximum temperatures across the region. The regional climate model, the conformal-cubic atmospheric model (CCAM), projects maximum temperatures increases over southern Africa to be in the order of 4 °C under low mitigation towards the end of the century or even higher. The statistical recalibration model is able to replicate these increasing temperatures, and the atmospheric thickness-maximum temperature relationship is shown to be stable under future climate conditions. Since dry land crop yields are not explicitly simulated by climate models but are sensitive to maximum temperature extremes, the effect of projected maximum temperature change on dry land crops of the Witbank maize production district of South Africa, assuming other factors remain unchanged, is then assessed by employing a statistical approach similar to the one used for maximum temperature projections.

Abstracts of the Annual Meeting of Planetary Geologic Mappers, Flagstaff, AZ, 2010

NASA Technical Reports Server (NTRS)

Bleamaster, Leslie F., III (Editor); Tanaka, Kenneth L. (Editor); Kelley, Michael S. (Editor)

2010-01-01

Topics covered include: Detailed Analysis of the Intra-Ejecta Dark Plains of Caloris Basin, Mercury; The Formation and Evolution of Tessera and Insights into the Beginning of Recorded History on Venus: Geology of the Fortuna Tessera Quadrangle (V-2); Geologic Map of the Snegurochka Planitia Quadrangle (V-1): Implications for the Volcanic History of the North Polar Region of Venus; Geological Map of the Fredegonade (V-57) Quadrangle, Venus: Status Report; Geologic Mapping of V-19; Geology of the Lachesis Tessera Quadrangle (V-18), Venus; Comparison of Mapping Tessera Terrain in the Phoebe Regio (V-41) and Tellus Tessera (V-10) Quadrangles; Geologic Mapping of the Devana Chasma (V-29) Quadrangle, Venus; Geologic Mapping of the Aristarchus Plateau Region on the Moon; Geologic Mapping of the Lunar South Pole Quadrangle (LQ-30); The Pilot Lunar Geologic Mapping Project: Summary Results and Recommendations from the Copernicus Quadrangle; Geologic Mapping of the Nili Fossae Region of Mars: MTM Quadrangles 20287, 20282, 25287, 25282, 30287, and 30282; Geologic Mapping of the Mawrth Vallis Region, Mars: MTM Quadrangles 25022, 25017, 25012, 20022, 20017, and 20012; Evidence for an Ancient Buried Landscape on the NW Rim of Hellas Basin, Mars; New Geologic Map of the Argyre Region of Mars: Deciphering the Geologic History Through Mars Global Surveyor, Mars Odyssey, and Mars Express Data; Geologic Mapping in the Hesperia Planum Region of Mars; Geologic Mapping of the Meridiani Region of Mars; Geologic Mapping in Southern Margaritifer Terra; Geology of -30247, -35247, and -40247 Quadrangles, Southern Hesperia Planum, Mars; The Interaction of Impact Melt, Impact-Derived Sediment, and Volatiles at Crater Tooting, Mars; Geologic Map of the Olympia Cavi Region of Mars (MTM 85200): A Summary of Tactical Approaches; Geology of the Terra Cimmeria-Utopia Planitia Highland Lowland Transitional Zone: Final Technical Approach and Scientific Results; Geology of Libya Montes and the Interbasin Plains of Northern Tyrrhena Terra, Mars: First Year Results and Second Year Work Plan; Mars Global Geologic Mapping Progress and Suggested Geographic-Based Hierarchal Systems for Unit Grouping and Naming; Progress in the Scandia Region Geologic Map of Mars; Geomorphic Mapping of MTMS -20022 and -20017; Geologic Mapping of the Medusae Fossae Formation, Mars, and the Northern Lowland Plains, Venus; Volcanism on Io: Results from Global Geologic Mapping; Employing Geodatabases for Planetary Mapping Conduct - Requirements, Concepts and Solutions; and Planetary Geologic Mapping Handbook - 2010.

CASK and CaMKII function in the mushroom body α′/β′ neurons during Drosophila memory formation

PubMed Central

Malik, Bilal R.; Gillespie, John Michael; Hodge, James J. L.

2013-01-01

Ca2+/CaM serine/threonine kinase II (CaMKII) is a central molecule in mechanisms of synaptic plasticity and memory. A vital feature of CaMKII in plasticity is its ability to switch to a calcium (Ca2+) independent constitutively active state after autophosphorylation at threonine 287 (T287). A second pair of sites, T306 T307 in the calmodulin (CaM) binding region once autophosphorylated, prevent subsequent CaM binding and inactivates the kinase during synaptic plasticity and memory. Recently a synaptic molecule called Ca2+/CaM-dependent serine protein kinase (CASK) has been shown to control both sets of CaMKII autophosphorylation events and hence is well poised to be a key regulator of memory. We show deletion of full length CASK or just its CaMK-like and L27 domains disrupts middle-term memory (MTM) and long-term memory (LTM), with CASK function in the α′/β′ subset of mushroom body neurons being required for memory. Likewise directly changing the levels of CaMKII autophosphorylation in these neurons removed MTM and LTM. The requirement of CASK and CaMKII autophosphorylation was not developmental as their manipulation just in the adult α′/β′ neurons was sufficient to remove memory. Overexpression of CASK or CaMKII in the α′/β′ neurons also occluded MTM and LTM. Overexpression of either Drosophila or human CASK in the α′/β′ neurons of the CASK mutant completely rescued memory, confirming that CASK signaling in α′/β′ neurons is necessary and sufficient for Drosophila memory formation and that the neuronal function of CASK is conserved between Drosophila and human. At the cellular level CaMKII overexpression in the α′/β′ neurons increased activity dependent Ca2+ responses while reduction of CaMKII decreased it. Likewise reducing CASK or directly expressing a phosphomimetic CaMKII T287D transgene in the α′/β′ similarly decreased Ca2+ signaling. Our results are consistent with CASK regulating CaMKII autophosphorylation in a pathway required for memory formation that involves activity dependent changes in Ca2+ signaling in the α′/β′ neurons. PMID:23543616

Mobile Health Technology Using a Wearable Sensorband for Female College Students With Problem Drinking: An Acceptability and Feasibility Study

PubMed Central

Silverman, Michelle; Sherpa, Dawa Phuti; Naegle, Madeline A; Kim, Hyorim; Coffman, Donna L; Ferdschneider, Marcy

2017-01-01

Background An increasing number of mobile app interventions have been developed for problem drinking among college students; however, few studies have examined the integration of a mobile app with continuous physiological monitoring and alerting of affective states related to drinking behaviors. Objective The aim of this paper was to evaluate the acceptability and feasibility of Mind the Moment (MtM), a theoretically based intervention for female college students with problem drinking that combines brief, in-person counseling with ecological momentary intervention (EMI) on a mobile app integrated with a wearable sensorband. Methods We recruited 10 non-treatment seeking, female undergraduates from a university health clinic who scored a 3 or higher on the Alcohol Use Disorders Identification Test–Consumption (AUDIT-C) to participate in this pilot study. Study activities involved an in-person baseline intake and 1 follow-up assessment, 2 in-person alcohol brief intervention counseling sessions, and use of MtM technology components (sensorband and EMI on a mobile app) for approximately 3-4 weeks. The intervention used motivational interviewing (MI) and cognitive behavioral therapy (CBT) strategies for reducing risks associated with drinking. We used both qualitative and quantitative assessments to measure acceptability of the intervention and feasibility of delivery. Use patterns of the sensorband and mobile app were also collected. Results Quantitative and qualitative data indicated high levels of acceptability for the MtM intervention. Altogether, participants made reports on the app on 26.7% (78/292) the days the technology was available to them and completed a total of 325 reports with wide variation between participants. Qualitative findings indicated that sensorband-elicited alerts promoted an increase in awareness of thoughts, feelings, and behaviors related to current environmental stressors and drinking behaviors in theoretically meaningful ways. Specific challenges related to functionality and form of the sensorband were identified. Conclusions Delivering intervention material “just-in-time,” at the moment participants need to use behavioral strategies has great potential to individualize behavioral interventions for reducing problem drinking and other health behaviors. These findings provide initial evidence for the promise of wearable sensors for increasing potency of theoretically grounded mobile health interventions and point to directions for future research and uptake of these technologies. PMID:28687533

Statistical downscaling of CMIP5 outputs for projecting future maximum and minimum temperature over the Haihe River Bain, China

NASA Astrophysics Data System (ADS)

Yan, Tiezhu; Shen, Zhenyao; Heng, Lee; Dercon, Gerd

2016-04-01

Future climate change information is important to formulate adaptation and mitigation strategies for climate change. In this study, a statistical downscaling model (SDSM) was established using both NCEP reanalysis data and ground observations (daily maximum and minimum temperature) during the period 1971-2010, and then calibrated model was applied to generate the future maximum and minimum temperature projections using predictors from the two CMIP5 models (MPI-ESM-LR and CNRM-CM5) under two Representative Concentration Pathway (RCP2.6 and RCP8.5) during the period 2011-2100 for the Haihe River Basin, China. Compared to the baseline period, future change in annual and seasonal maximum and minimum temperature was computed after bias correction. The spatial distribution and trend change of annual maximum and minimum temperature were also analyzed using ensemble projections. The results shows that: (1)The downscaling model had a good applicability on reproducing daily and monthly mean maximum and minimum temperature over the whole basin. (2) Bias was observed when using historical predictors from CMIP5 models and the performance of CNRM-CM5 was a little worse than that of MPI-ESM-LR. (3) The change in annual mean maximum and minimum temperature under the two scenarios in 2020s, 2050s and 2070s will increase and magnitude of maximum temperature will be higher than minimum temperature. (4) The increase in temperature in the mountains and along the coastline is remarkably high than the other parts of the studies basin. (5) For annual maximum and minimum temperature, the significant upward trend will be obtained under RCP 8.5 scenario and the magnitude will be 0.37 and 0.39 ℃ per decade, respectively; the increase in magnitude under RCP 2.6 scenario will be upward in 2020s and then decrease in 2050s and 2070s, and the magnitude will be 0.01 and 0.01℃ per decade, respectively.

Fabrication of a First Article Lightweight Composite Technology Demonstrator - Exospine

DTIC Science & Technology

2014-01-01

core, (b) 0/90, and (c) ± 45 ply cuts of ACG-MTM 45-1/CF0526 prepreg fabric...onboard diagnostics. 2. Experimental 2.1 Materials Plain woven carbon fiber/epoxy prepreg and a low-density foam core were provided to ARL for the...fabrication of the exospine technology demonstrator by UD-CCM. The prepreg was ACG - MTM∗ 45-1/CF0526 and has a cured ply thickness of 0.201 mm. It is

Topographic Map of the West Candor Chasma Region of Mars, MTM 500k -05/282E OMKT

USGS Publications Warehouse

,

2004-01-01

This map, compiled photogrammetrically from Viking Orbiter stereo image pairs, is part of a series of topographic maps of areas of special scientific interest on Mars. The figure of Mars used for the computation of the map projection is an oblate spheroid (flattening of 1/176.875) with an equatorial radius of 3396.0 km and a polar radius of 3376.8 km. The datum (the 0-km contour line) for elevations is defined as the equipotential surface (gravitational plus rotational) whose average value at the equator is equal to the mean radius as determined by Mars Orbiter Laser Altimeter. The projection is part of a Mars Transverse Mercator (MTM) system with 20? wide zones. For the area covered by this map sheet the central meridian is at 290? E. (70? W.). The scale factor at the central meridian of the zone containing this quadrangle is 0.9960 relative to a nominal scale of 1:500,000. Longitude increases to the east and latitude is planetocentric as allowed by IAU/IAG standards and in accordance with current NASA and USGS standards. A secondary grid (printed in red) has been added to the map as a reference to the west longitude/planetographic latitude system that is also allowed by IAU/IAG standards and has been used for previous Mars maps.

Topographic Map of the Ophir and Central Candor Chasmata Region of Mars MTM 500k -05/287E OMKT

USGS Publications Warehouse

,

2004-01-01

This map, compiled photogrammetrically from Viking Orbiter stereo image pairs, is part of a series of topographic maps of areas of special scientific interest on Mars. The figure of Mars used for the computation of the map projection is an oblate spheroid (flattening of 1/176.875) with an equatorial radius of 3396.0 km and a polar radius of 3376.8 km. The datum (the 0-km contour line) for elevations is defined as the equipotential surface (gravitational plus rotational) whose average value at the equator is equal to the mean radius as determined by Mars Orbiter Laser Altimeter. The projection is part of a Mars Transverse Mercator (MTM) system with 20? wide zones. For the area covered by this map sheet the central meridian is at 290? E. (70? W.). The scale factor at the central meridian of the zone containing this quadrangle is 0.9960 relative to a nominal scale of 1:500,000. Longitude increases to the east and latitude is planetocentric as allowed by IAU/IAG standards and in accordance with current NASA and USGS standards. A secondary grid (printed in red) has been added to the map as a reference to the west longitude/planetographic latitude system that is also allowed by IAU/IAG standards and has been used for previous Mars maps.

Topographic map of the Tithonium Chasma Region of Mars, MTM 500k -05/277E OMKT

USGS Publications Warehouse

,

2004-01-01

This map, compiled photogrammetrically from Viking Orbiter stereo image pairs, is part of a series of topographic maps of areas of special scientific interest on Mars. The figure of Mars used for the computation of the map projection is an oblate spheroid (flattening of 1/176.875) with an equatorial radius of 3396.0 km and a polar radius of 3376.8 km. The datum (the 0-km contour line) for elevations is defined as the equipotential surface (gravitational plus rotational) whose average value at the equator is equal to the mean radius as determined by Mars Orbiter Laser Altimeter. The projection is part of a Mars Transverse Mercator (MTM) system with 20? wide zones. For the area covered by this map sheet the central meridian is at 270? E. (70? W.). The scale factor at the central meridian of the zone containing this quadrangle is 0.9960 relative to a nominal scale of 1:500,000. Longitude increases to the east and latitude is planetocentric as allowed by IAU/IAG standards and in accordance with current NASA and USGS standards. A secondary grid (printed in red) has been added to the map as a reference to the west longitude/planetographic latitude system that is also allowed by IAU/IAG standards and has been used for previous Mars maps.

Large-scale, thick, self-assembled, nacre-mimetic brick-walls as fire barrier coatings on textiles

PubMed Central

Das, Paramita; Thomas, Helga; Moeller, Martin; Walther, Andreas

2017-01-01

Highly loaded polymer/clay nanocomposites with layered structures are emerging as robust fire retardant surface coatings. However, time-intensive sequential deposition processes, e.g. layer-by-layer strategies, hinders obtaining large coating thicknesses and complicates an implementation into existing technologies. Here, we demonstrate a single-step, water-borne approach to prepare thick, self-assembling, hybrid fire barrier coatings of sodium carboxymethyl cellulose (CMC)/montmorillonite (MTM) with well-defined, bioinspired brick-wall nanostructure, and showcase their application on textile. The coating thickness on the textile is tailored using different concentrations of CMC/MTM (1–5 wt%) in the coating bath. While lower concentrations impart conformal coatings of fibers, thicker continuous coatings are obtained on the textile surface from highest concentration. Comprehensive fire barrier and fire retardancy tests elucidate the increasing fire barrier and retardancy properties with increasing coating thickness. The materials are free of halogen and heavy metal atoms, and are sourced from sustainable and partly even renewable building blocks. We further introduce an amphiphobic surface modification on the coating to impart oil and water repellency, as well as self-cleaning features. Hence, our study presents a generic, environmentally friendly, scalable, and one-pot coating approach that can be introduced into existing technologies to prepare bioinspired, thick, fire barrier nanocomposite coatings on diverse surfaces. PMID:28054589

Steering of aggregating magnetic microparticles using propulsion gradients coils in an MRI Scanner.

PubMed

Mathieu, Jean-Baptiste; Martel, Sylvain

2010-05-01

Upgraded gradient coils can effectively enhance the MRI steering of magnetic microparticles in a branching channel. Applications of this method include MRI targeting of magnetic embolization agents for oncologic therapy. A magnetic suspension of Fe(3)O(4) magnetic particles was injected inside a y-shaped microfluidic channel. Magnetic gradients of 0, 50, 100, 200, and 400 mT/m were applied to the magnetic particles perpendicularly to the flow by a custom-built gradient coil inside a 1.5-T MRI scanner. Measurement of the steering ratio was performed both by video analyses and quantification of the mass of the particles collected at each outlet of the microfluidic channel, using atomic absorption spectroscopy. Magnetic particles steering ratios of 0.99 and 0.75 were reached with 400 mT/m gradient amplitude and measured by video analyses and atomic absorption spectroscopy, respectively. Experimental data shows that the steering ratio increases with higher magnetic gradients. Moreover, theory suggests that larger particles (or aggregates), higher magnetizations, and lower flows can also be used to improve the steering ratio. The technological limitation of the approach is that an MRI gradient amplitude increase to a few hundred milliteslas per meter is needed. A simple analytical method based on magnetophoretic velocity predictions and geometric considerations is proposed for steering ratio calculation. (c) 2010 Wiley-Liss, Inc.

Delayed effects of low level acute irradiation and chronic environmental radioactive contamination on DNA lymphocytes of people living in Dolon, a settlement located in the vicinity of the Semipalatinsk nuclear test site (Kazakhstan).

PubMed

Chenal, C; Legue, F; Nourgalieva, K

2006-10-01

During 42 years several hundred nuclear tests were performed by the former USSR at the Semipalatinsk Test Site (STS, Kazakhstan), of which more than 100 were done in the atmosphere. We report here the late genetic damage of external exposure to radiation and environmental radioactive contamination in people living in Dolon, a small settlement situated in the vicinity of the STS. The comet assay was applied on DNA lymphocytes of 20 exposed women and 32 non-exposed women living at 500 km from the STS. We observed a statistically significant difference between the exposed and control groups for mean tail moment (MTM) and DNA% in the tail. The mean values of all comet assay parameters (MTM, DNA% in the tail and score) were higher in the group of women born before 1949 as compared to those born after 1950, which could reflect an effect of external irradiation in 1949 due to the most contaminating explosion. These results suggest that people exposed 50 years ago to relatively small doses of external irradiation and/or still living in an environment contaminated by small amounts of long life radionuclides, still present DNA damage which is in agreement with other cytogenetical studies performed at the same site, on the same population.

Topographic map of the Parana Valles region of Mars MTM 500k -25/337E OMKT

USGS Publications Warehouse

,

2003-01-01

This map, compiled photogrammetrically from Viking Orbiter stereo image pairs, is part of a series of topographic maps of areas of special scientific interest on Mars. MTM 500k –25/347E OMKT: Abbreviation for Mars Transverse Mercator; 1:500,000 series; center of sheet latitude 25° S., longitude 347.5° E. in planetocentric coordinate system (this corresponds to –25/012; latitude 25° S., longitude 12.5° W. in planetographic coordinate system); orthophotomosaic (OM) with color coded (K) topographic contours and nomenclature (T) [Greeley and Batson, 1990]. The figure of Mars used for the computation of the map projection is an oblate spheroid (flattening of 1/176.875) with an equatorial radius of 3396.0 km and a polar radius of 3376.8 km (Kirk and others, 2000). The datum (the 0-km contour line) for elevations is defined as the equipotential surface (gravitational plus rotational) whose average value at the equator is equal to the mean radius as determined by Mars Orbiter Laser Altimeter (Smith and others, 2001). The image base for this map employs Viking Orbiter images from orbit 651. An orthophotomosaic was created on the digital photogrammetric workstation using the DTM compiled from stereo models. Integrated Software for Imagers and Spectrometers (ISIS) (Torson and Becker, 1997) provided the software to project the orthophotomosaic into the Transverse Mercator Projection.

Topographic Map of the Northwest Loire Valles Region of Mars MTM 500k -15/337E OMKT

USGS Publications Warehouse

,

2003-01-01

This map, compiled photogrammetrically from Viking Orbiter stereo image pairs, is part of a series of topographic maps of areas of special scientific interest on Mars. MTM 500k –15/337E OMKT: Abbreviation for Mars Transverse Mercator; 1:500,000 series; center of sheet latitude 15° S., longitude 337.5° E. in planetocentric coordinate system (this corresponds to –15/022; latitude 15° S., longitude 22.5° W. in planetographic coordinate system); orthophotomosaic (OM) with color coded (K) topographic contours and nomenclature (T) [Greeley and Batson, 1990]. The figure of Mars used for the computation of the map projection is an oblate spheroid (flattening of 1/176.875) with an equatorial radius of 3396.0 km and a polar radius of 3376.8 km (Kirk and others, 2000). The datum (the 0–km contour line) for elevations is defined as the equipotential surface (gravitational plus rotational) whose average value at the equator is equal to the mean radius as determined by Mars Orbiter Laser Altimeter (Smith and others, 2001). The image base for this map employs Viking Orbiter images from orbit 651. An orthophotomosaic was created on the digital photogrammetric workstation using the DTM compiled from stereo models. Integrated Software for Imagers and Spectrometers (ISIS) (Torson and Becker, 1997) provided the software to project the orthophotomosaic into the Transverse Mercator Projection.

Stochastic modelling of the monthly average maximum and minimum temperature patterns in India 1981-2015

NASA Astrophysics Data System (ADS)

Narasimha Murthy, K. V.; Saravana, R.; Vijaya Kumar, K.

2018-04-01

The paper investigates the stochastic modelling and forecasting of monthly average maximum and minimum temperature patterns through suitable seasonal auto regressive integrated moving average (SARIMA) model for the period 1981-2015 in India. The variations and distributions of monthly maximum and minimum temperatures are analyzed through Box plots and cumulative distribution functions. The time series plot indicates that the maximum temperature series contain sharp peaks in almost all the years, while it is not true for the minimum temperature series, so both the series are modelled separately. The possible SARIMA model has been chosen based on observing autocorrelation function (ACF), partial autocorrelation function (PACF), and inverse autocorrelation function (IACF) of the logarithmic transformed temperature series. The SARIMA (1, 0, 0) × (0, 1, 1)12 model is selected for monthly average maximum and minimum temperature series based on minimum Bayesian information criteria. The model parameters are obtained using maximum-likelihood method with the help of standard error of residuals. The adequacy of the selected model is determined using correlation diagnostic checking through ACF, PACF, IACF, and p values of Ljung-Box test statistic of residuals and using normal diagnostic checking through the kernel and normal density curves of histogram and Q-Q plot. Finally, the forecasting of monthly maximum and minimum temperature patterns of India for the next 3 years has been noticed with the help of selected model.

Estimating missing daily temperature extremes in Jaffna, Sri Lanka

NASA Astrophysics Data System (ADS)

Thevakaran, A.; Sonnadara, D. U. J.

2018-04-01

The accuracy of reconstructing missing daily temperature extremes in the Jaffna climatological station, situated in the northern part of the dry zone of Sri Lanka, is presented. The adopted method utilizes standard departures of daily maximum and minimum temperature values at four neighbouring stations, Mannar, Anuradhapura, Puttalam and Trincomalee to estimate the standard departures of daily maximum and minimum temperatures at the target station, Jaffna. The daily maximum and minimum temperatures from 1966 to 1980 (15 years) were used to test the validity of the method. The accuracy of the estimation is higher for daily maximum temperature compared to daily minimum temperature. About 95% of the estimated daily maximum temperatures are within ±1.5 °C of the observed values. For daily minimum temperature, the percentage is about 92. By calculating the standard deviation of the difference in estimated and observed values, we have shown that the error in estimating the daily maximum and minimum temperatures is ±0.7 and ±0.9 °C, respectively. To obtain the best accuracy when estimating the missing daily temperature extremes, it is important to include Mannar which is the nearest station to the target station, Jaffna. We conclude from the analysis that the method can be applied successfully to reconstruct the missing daily temperature extremes in Jaffna where no data is available due to frequent disruptions caused by civil unrests and hostilities in the region during the period, 1984 to 2000.

40 CFR Table 4 to Subpart Ooo of... - Operating Parameter Levels

Code of Federal Regulations, 2012 CFR

2012-07-01

... temperature Maximum temperature Carbon absorber Total regeneration steam or nitrogen flow, or pressure (gauge or absolute) a during carbon bed regeneration cycle; and temperature of the carbon bed after regeneration (and within 15 minutes of completing any cooling cycle(s)) Maximum flow or pressure; and maximum...

14 CFR 29.1521 - Powerplant limitations.

Code of Federal Regulations, 2012 CFR

2012-01-01

... pressure (for reciprocating engines); (3) The maximum allowable turbine inlet or turbine outlet gas temperature (for turbine engines); (4) The maximum allowable power or torque for each engine, considering the... maximum allowable turbine inlet or turbine outlet gas temperature (for turbine engines); (5) The maximum...

14 CFR 29.1521 - Powerplant limitations.

Code of Federal Regulations, 2013 CFR

2013-01-01

... pressure (for reciprocating engines); (3) The maximum allowable turbine inlet or turbine outlet gas temperature (for turbine engines); (4) The maximum allowable power or torque for each engine, considering the... maximum allowable turbine inlet or turbine outlet gas temperature (for turbine engines); (5) The maximum...

14 CFR 29.1521 - Powerplant limitations.

Code of Federal Regulations, 2014 CFR

2014-01-01

... pressure (for reciprocating engines); (3) The maximum allowable turbine inlet or turbine outlet gas temperature (for turbine engines); (4) The maximum allowable power or torque for each engine, considering the... maximum allowable turbine inlet or turbine outlet gas temperature (for turbine engines); (5) The maximum...

14 CFR 29.1521 - Powerplant limitations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... pressure (for reciprocating engines); (3) The maximum allowable turbine inlet or turbine outlet gas temperature (for turbine engines); (4) The maximum allowable power or torque for each engine, considering the... maximum allowable turbine inlet or turbine outlet gas temperature (for turbine engines); (5) The maximum...

14 CFR 29.1521 - Powerplant limitations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... pressure (for reciprocating engines); (3) The maximum allowable turbine inlet or turbine outlet gas temperature (for turbine engines); (4) The maximum allowable power or torque for each engine, considering the... maximum allowable turbine inlet or turbine outlet gas temperature (for turbine engines); (5) The maximum...

On the Trend of the Annual Mean, Maximum, and Minimum Temperature and the Diurnal Temperature Range in the Armagh Observatory, Northern Ireland, Dataset, 1844 -2012

NASA Technical Reports Server (NTRS)

Wilson, Robert M.

2013-01-01

Examined are the annual averages, 10-year moving averages, decadal averages, and sunspot cycle (SC) length averages of the mean, maximum, and minimum surface air temperatures and the diurnal temperature range (DTR) for the Armagh Observatory, Northern Ireland, during the interval 1844-2012. Strong upward trends are apparent in the Armagh surface-air temperatures (ASAT), while a strong downward trend is apparent in the DTR, especially when the ASAT data are averaged by decade or over individual SC lengths. The long-term decrease in the decadaland SC-averaged annual DTR occurs because the annual minimum temperatures have risen more quickly than the annual maximum temperatures. Estimates are given for the Armagh annual mean, maximum, and minimum temperatures and the DTR for the current decade (2010-2019) and SC24.

Exhaust-Gas Pressure and Temperature Survey of F404-GE-400 Turbofan Engine

NASA Technical Reports Server (NTRS)

Walton, James T.; Burcham, Frank W., Jr.

1986-01-01

An exhaust-gas pressure and temperature survey of the General Electric F404-GE-400 turbofan engine was conducted in the altitude test facility of the NASA Lewis Propulsion System Laboratory. Traversals by a survey rake were made across the exhaust-nozzle exit to measure the pitot pressure and total temperature. Tests were performed at Mach 0.87 and a 24,000-ft altitude and at Mach 0.30 and a 30,000-ft altitude with various power settings from intermediate to maximum afterburning. Data yielded smooth pressure and temperature profiles with maximum jet temperatures approximately 1.4 in. inside the nozzle edge and maximum jet temperatures from 1 to 3 in. inside the edge. A low-pressure region located exactly at engine center was noted. The maximum temperature encountered was 3800 R.

Condensation Heat Transfer of Steam on a Single Horizontal Tube.

DTIC Science & Technology

1983-06-01

public release; distribution unlimited 88 09 07 1?0 L_ I jmmAzzLEim. SICUR1TY CLASStFICATION o« THIS r-AOt (*»*< Data Enf«r»d) REPORT...steam side data were taken at atmospheric pressure to test the data acquisition/reduction computer programs.^— S N 0102- LF. 014-1601 Accession For...Dlst H Special UNCLASSIFIED ItCUHlTV CLASSIFICATION O» TMI( PAOtyWft«! Data >*H mtm Im. ! Approved for public release; distribution

Small Tactical Unmanned Aerial System (STUAS) Rapid Integration and Fielding Process (RAIN)

DTIC Science & Technology

2013-09-01

121A4 September 2013 Thesis Advisor: Rama Gehris Co-Advisor: Bonnie Young THIS PAGE INTENTIONALLY LEFT BLANK i REPORT...11~ ... . , - ... $tlo.rotfydle:IW#hlt I •:tl ~dciwolloCII’fil -K ~IOI’I.,....UMdto~~h..,orj ’Bj ~ $11owh~t:~I) Cft .... l’utopK i7, MtM rf Mtdlar...Trndc-off Anolysis Rcsulls ’ll•c trnde-ofl’ Analysis results will be a summary of tho conclusions derived from incorporating aml analyzing tho

Topographic map of part of the Kasei Valles and Sacra Fossae regions of Mars - MTM 500k 20/287E OMKT

USGS Publications Warehouse

Rosiek, Mark R.; Redding, Bonnie L.; Galuszca, Donna M.

2005-01-01

This map is part of a series of topographic maps of areas of special scientific interest on Mars. The topography was compiled photogrammetrically using Viking Orbiter stereo image pairs and photoclinometry from a Viking Orbiter image. The contour interval is 250 m. Horizontal and vertical control was established using the USGS Mars Digital Image Model 2.0 (MDIM 2.0) and data from the Mars Orbiter Laser Altimeter (MOLA).

Spectrophotometry of stars 9 - 12m north polar spectrophotometric sequence (NPSS) program.

NASA Astrophysics Data System (ADS)

Sharipova, L. M.; Prokof'eva, V. V.

Spectrophotometric observations of stars 9 - 12m of the NPSS program have been made with the use of hgh-sensitivity light-detecting apparatus of the digital television complex of the 0.5-m Maksutov telescope MTM-500 and original slitless spectrograph. Atmospheric extinction was controlled during the night by means of an energetically calibrated brightness standard. Absolute energy distributions of 12 stars, their synthetic magnitudes in the V band, and B-V color indices were obtained.

Measurement of D0 Azimuthal Anisotropy at Midrapidity in Au +Au Collisions at √{sN N }=200 GeV

NASA Astrophysics Data System (ADS)

Adamczyk, L.; Adkins, J. K.; Agakishiev, G.; Aggarwal, M. M.; Ahammed, Z.; Ajitanand, N. N.; Alekseev, I.; Anderson, D. M.; Aoyama, R.; Aparin, A.; Arkhipkin, D.; Aschenauer, E. C.; Ashraf, M. U.; Attri, A.; Averichev, G. S.; Bai, X.; Bairathi, V.; Behera, A.; Bellwied, R.; Bhasin, A.; Bhati, A. K.; Bhattarai, P.; Bielcik, J.; Bielcikova, J.; Bland, L. C.; Bordyuzhin, I. G.; Bouchet, J.; Brandenburg, J. D.; Brandin, A. V.; Brown, D.; Bunzarov, I.; Butterworth, J.; Caines, H.; Calderón de la Barca Sánchez, M.; Campbell, J. M.; Cebra, D.; Chakaberia, I.; Chaloupka, P.; Chang, Z.; Chankova-Bunzarova, N.; Chatterjee, A.; Chattopadhyay, S.; Chen, X.; Chen, J. H.; Chen, X.; Cheng, J.; Cherney, M.; Christie, W.; Contin, G.; Crawford, H. J.; Das, S.; De Silva, L. C.; Debbe, R. R.; Dedovich, T. G.; Deng, J.; Derevschikov, A. A.; Didenko, L.; Dilks, C.; Dong, X.; Drachenberg, J. L.; Draper, J. E.; Dunkelberger, L. E.; Dunlop, J. C.; Efimov, L. G.; Elsey, N.; Engelage, J.; Eppley, G.; Esha, R.; Esumi, S.; Evdokimov, O.; Ewigleben, J.; Eyser, O.; Fatemi, R.; Fazio, S.; Federic, P.; Federicova, P.; Fedorisin, J.; Feng, Z.; Filip, P.; Finch, E.; Fisyak, Y.; Flores, C. E.; Fulek, L.; Gagliardi, C. A.; Garand, D.; Geurts, F.; Gibson, A.; Girard, M.; Greiner, L.; Grosnick, D.; Gunarathne, D. S.; Guo, Y.; Gupta, A.; Gupta, S.; Guryn, W.; Hamad, A. I.; Hamed, A.; Harlenderova, A.; Harris, J. W.; He, L.; Heppelmann, S.; Heppelmann, S.; Hirsch, A.; Hoffmann, G. W.; Horvat, S.; Huang, T.; Huang, B.; Huang, X.; Huang, H. Z.; Humanic, T. J.; Huo, P.; Igo, G.; Jacobs, W. W.; Jentsch, A.; Jia, J.; Jiang, K.; Jowzaee, S.; Judd, E. G.; Kabana, S.; Kalinkin, D.; Kang, K.; Kauder, K.; Ke, H. W.; Keane, D.; Kechechyan, A.; Khan, Z.; Kikoła, D. P.; Kisel, I.; Kisiel, A.; Kochenda, L.; Kocmanek, M.; Kollegger, T.; Kosarzewski, L. K.; Kraishan, A. F.; Kravtsov, P.; Krueger, K.; Kulathunga, N.; Kumar, L.; Kvapil, J.; Kwasizur, J. H.; Lacey, R.; Landgraf, J. M.; Landry, K. D.; Lauret, J.; Lebedev, A.; Lednicky, R.; Lee, J. H.; Li, X.; Li, C.; Li, W.; Li, Y.; Lidrych, J.; Lin, T.; Lisa, M. A.; Liu, H.; Liu, P.; Liu, Y.; Liu, F.; Ljubicic, T.; Llope, W. J.; Lomnitz, M.; Longacre, R. S.; Luo, S.; Luo, X.; Ma, G. L.; Ma, L.; Ma, Y. G.; Ma, R.; Magdy, N.; Majka, R.; Mallick, D.; Margetis, S.; Markert, C.; Matis, H. S.; Meehan, K.; Mei, J. C.; Miller, Z. W.; Minaev, N. G.; Mioduszewski, S.; Mishra, D.; Mizuno, S.; Mohanty, B.; Mondal, M. M.; Morozov, D. A.; Mustafa, M. K.; Nasim, Md.; Nayak, T. K.; Nelson, J. M.; Nie, M.; Nigmatkulov, G.; Niida, T.; Nogach, L. V.; Nonaka, T.; Nurushev, S. B.; Odyniec, G.; Ogawa, A.; Oh, K.; Okorokov, V. A.; Olvitt, D.; Page, B. S.; Pak, R.; Pandit, Y.; Panebratsev, Y.; Pawlik, B.; Pei, H.; Perkins, C.; Pile, P.; Pluta, J.; Poniatowska, K.; Porter, J.; Posik, M.; Poskanzer, A. M.; Pruthi, N. K.; Przybycien, M.; Putschke, J.; Qiu, H.; Quintero, A.; Ramachandran, S.; Ray, R. L.; Reed, R.; Rehbein, M. J.; Ritter, H. G.; Roberts, J. B.; Rogachevskiy, O. V.; Romero, J. L.; Roth, J. D.; Ruan, L.; Rusnak, J.; Rusnakova, O.; Sahoo, N. R.; Sahu, P. K.; Salur, S.; Sandweiss, J.; Saur, M.; Schambach, J.; Schmah, A. M.; Schmidke, W. B.; Schmitz, N.; Schweid, B. R.; Seger, J.; Sergeeva, M.; Seyboth, P.; Shah, N.; Shahaliev, E.; Shanmuganathan, P. V.; Shao, M.; Sharma, A.; Sharma, M. K.; Shen, W. Q.; Shi, Z.; Shi, S. S.; Shou, Q. Y.; Sichtermann, E. P.; Sikora, R.; Simko, M.; Singha, S.; Skoby, M. J.; Smirnov, N.; Smirnov, D.; Solyst, W.; Song, L.; Sorensen, P.; Spinka, H. M.; Srivastava, B.; Stanislaus, T. D. S.; Strikhanov, M.; Stringfellow, B.; Sugiura, T.; Sumbera, M.; Summa, B.; Sun, Y.; Sun, X. M.; Sun, X.; Surrow, B.; Svirida, D. N.; Szelezniak, M. A.; Tang, A. H.; Tang, Z.; Taranenko, A.; Tarnowsky, T.; Tawfik, A.; Thäder, J.; Thomas, J. H.; Timmins, A. R.; Tlusty, D.; Todoroki, T.; Tokarev, M.; Trentalange, S.; Tribble, R. E.; Tribedy, P.; Tripathy, S. K.; Trzeciak, B. A.; Tsai, O. D.; Ullrich, T.; Underwood, D. G.; Upsal, I.; Van Buren, G.; van Nieuwenhuizen, G.; Vasiliev, A. N.; Videbæk, F.; Vokal, S.; Voloshin, S. A.; Vossen, A.; Wang, G.; Wang, Y.; Wang, F.; Wang, Y.; Webb, J. C.; Webb, G.; Wen, L.; Westfall, G. D.; Wieman, H.; Wissink, S. W.; Witt, R.; Wu, Y.; Xiao, Z. G.; Xie, W.; Xie, G.; Xu, J.; Xu, N.; Xu, Q. H.; Xu, Y. F.; Xu, Z.; Yang, Y.; Yang, Q.; Yang, C.; Yang, S.; Ye, Z.; Ye, Z.; Yi, L.; Yip, K.; Yoo, I.-K.; Yu, N.; Zbroszczyk, H.; Zha, W.; Zhang, Z.; Zhang, X. P.; Zhang, J. B.; Zhang, S.; Zhang, J.; Zhang, Y.; Zhang, J.; Zhang, S.; Zhao, J.; Zhong, C.; Zhou, L.; Zhou, C.; Zhu, X.; Zhu, Z.; Zyzak, M.; STAR Collaboration

2017-05-01

We report the first measurement of the elliptic anisotropy (v2) of the charm meson D0 at midrapidity (|y |<1 ) in Au +Au collisions at √{sN N}=200 GeV . The measurement was conducted by the STAR experiment at RHIC utilizing a new high-resolution silicon tracker. The measured D0 v2 in 0%-80% centrality Au +Au collisions can be described by a viscous hydrodynamic calculation for a transverse momentum (pT) of less than 4 GeV /c . The D0 v2 as a function of transverse kinetic energy (mT-m0, where mT=√{pT2+m02 }) is consistent with that of light mesons in 10%-40% centrality Au +Au collisions. These results suggest that charm quarks have achieved local thermal equilibrium with the medium created in such collisions. Several theoretical models, with the temperature-dependent, dimensionless charm spatial diffusion coefficient (2 π T Ds) in the range of ˜2 - 12 , are able to simultaneously reproduce our D0 v2 result and our previously published results for the D0 nuclear modification factor.

A Negative Index Metamaterial-Inspired UWB Antenna with an Integration of Complementary SRR and CLS Unit Cells for Microwave Imaging Sensor Applications

PubMed Central

Islam, Mohammad Tariqul; Islam, Md. Moinul; Samsuzzaman, Md.; Faruque, Mohammad Rashed Iqbal; Misran, Norbahiah

2015-01-01

This paper presents a negative index metamaterial incorporated UWB antenna with an integration of complementary SRR (split-ring resonator) and CLS (capacitive loaded strip) unit cells for microwave imaging sensor applications. This metamaterial UWB antenna sensor consists of four unit cells along one axis, where each unit cell incorporates a complementary SRR and CLS pair. This integration enables a design layout that allows both a negative value of permittivity and a negative value of permeability simultaneous, resulting in a durable negative index to enhance the antenna sensor performance for microwave imaging sensor applications. The proposed MTM antenna sensor was designed and fabricated on an FR4 substrate having a thickness of 1.6 mm and a dielectric constant of 4.6. The electrical dimensions of this antenna sensor are 0.20 λ × 0.29 λ at a lower frequency of 3.1 GHz. This antenna sensor achieves a 131.5% bandwidth (VSWR < 2) covering the frequency bands from 3.1 GHz to more than 15 GHz with a maximum gain of 6.57 dBi. High fidelity factor and gain, smooth surface-current distribution and nearly omni-directional radiation patterns with low cross-polarization confirm that the proposed negative index UWB antenna is a promising entrant in the field of microwave imaging sensors. PMID:26007721

A Negative Index Metamaterial-Inspired UWB Antenna with an Integration of Complementary SRR and CLS Unit Cells for Microwave Imaging Sensor Applications.

PubMed

Islam, Mohammad Tariqul; Islam, Md Moinul; Samsuzzaman, Md; Faruque, Mohammad Rashed Iqbal; Misran, Norbahiah

2015-05-20

This paper presents a negative index metamaterial incorporated UWB antenna with an integration of complementary SRR (split-ring resonator) and CLS (capacitive loaded strip) unit cells for microwave imaging sensor applications. This metamaterial UWB antenna sensor consists of four unit cells along one axis, where each unit cell incorporates a complementary SRR and CLS pair. This integration enables a design layout that allows both a negative value of permittivity and a negative value of permeability simultaneous, resulting in a durable negative index to enhance the antenna sensor performance for microwave imaging sensor applications. The proposed MTM antenna sensor was designed and fabricated on an FR4 substrate having a thickness of 1.6 mm and a dielectric constant of 4.6. The electrical dimensions of this antenna sensor are 0.20 λ × 0.29 λ at a lower frequency of 3.1 GHz. This antenna sensor achieves a 131.5% bandwidth (VSWR < 2) covering the frequency bands from 3.1 GHz to more than 15 GHz with a maximum gain of 6.57 dBi. High fidelity factor and gain, smooth surface-current distribution and nearly omni-directional radiation patterns with low cross-polarization confirm that the proposed negative index UWB antenna is a promising entrant in the field of microwave imaging sensors.

A Miniaturized Antenna with Negative Index Metamaterial Based on Modified SRR and CLS Unit Cell for UWB Microwave Imaging Applications.

PubMed

Islam, Md Moinul; Islam, Mohammad Tariqul; Samsuzzaman, Md; Faruque, Mohammad Rashed Iqbal; Misran, Norbahiah; Mansor, Mohd Fais

2015-01-23

A miniaturized antenna employing a negative index metamaterial with modified split-ring resonator (SRR) and capacitance-loaded strip (CLS) unit cells is presented for Ultra wideband (UWB) microwave imaging applications. Four left-handed (LH) metamaterial (MTM) unit cells are located along one axis of the antenna as the radiating element. Each left-handed metamaterial unit cell combines a modified split-ring resonator (SRR) with a capacitance-loaded strip (CLS) to obtain a design architecture that simultaneously exhibits both negative permittivity and negative permeability, which ensures a stable negative refractive index to improve the antenna performance for microwave imaging. The antenna structure, with dimension of 16 × 21 × 1.6 mm³, is printed on a low dielectric FR4 material with a slotted ground plane and a microstrip feed. The measured reflection coefficient demonstrates that this antenna attains 114.5% bandwidth covering the frequency band of 3.4-12.5 GHz for a voltage standing wave ratio of less than 2 with a maximum gain of 5.16 dBi at 10.15 GHz. There is a stable harmony between the simulated and measured results that indicate improved nearly omni-directional radiation characteristics within the operational frequency band. The stable surface current distribution, negative refractive index characteristic, considerable gain and radiation properties make this proposed negative index metamaterial antenna optimal for UWB microwave imaging applications.

Dominant covarying climate signals in the Southern Ocean and Antarctic Sea Ice influence during last three decades

NASA Astrophysics Data System (ADS)

Cerrone, Dario; Fusco, Giannetta; Simmonds, Ian; Aulicino, Giuseppe; Budillon, Giorgio

2017-04-01

A composite dataset (comprising geopotential height, sea surface temperature, zonal and meridional surface winds, precipitation, cloud cover, surface air temperature, latent plus sensible heat fluxes , and sea ice concentration) has been investigated with the aim of revealing the dominant timescales of variability from 1982 to 2013. Three covarying climate signals associated with variations in the sea ice distribution around Antarctica have been detected through the application of the Multiple-Taper Method with Singular Value Decomposition (MTM-SVD). Features of the established patterns of variation over the Southern Hemisphere (SH) extratropics have been identified in each of these three climate signals in the form of coupled or individual oscillations. The climate patterns considered here are the Southern Annular Mode (SAM), the Pacific-South America (PSA) teleconnection, the Semi-Annual Oscillation (SAO) and Zonal Wavenumber-3 (ZW3) mode. It is shown that most of the sea ice temporal variance is concentrated at the quasi-triennial scale resulting from the constructive superposition of the PSA and ZW3 patterns. In addition the combination of the SAM and SAO patterns is found to promote the interannual sea ice variations underlying a general change in the Southern Ocean atmospheric and oceanic circulations. These two modes of variability are also found consistent with the occurrence of the SAM+/PSA- or SAM-/PSA+ combinations, which could have favored the cooling of the sub-Antarctic and important changes in the Antarctic sea ice distribution since 2000.

Finite Element Method (FEM) Modeling of Freeze-drying: Monitoring Pharmaceutical Product Robustness During Lyophilization.

PubMed

Chen, Xiaodong; Sadineni, Vikram; Maity, Mita; Quan, Yong; Enterline, Matthew; Mantri, Rao V

2015-12-01

Lyophilization is an approach commonly undertaken to formulate drugs that are unstable to be commercialized as ready to use (RTU) solutions. One of the important aspects of commercializing a lyophilized product is to transfer the process parameters that are developed in lab scale lyophilizer to commercial scale without a loss in product quality. This process is often accomplished by costly engineering runs or through an iterative process at the commercial scale. Here, we are highlighting a combination of computational and experimental approach to predict commercial process parameters for the primary drying phase of lyophilization. Heat and mass transfer coefficients are determined experimentally either by manometric temperature measurement (MTM) or sublimation tests and used as inputs for the finite element model (FEM)-based software called PASSAGE, which computes various primary drying parameters such as primary drying time and product temperature. The heat and mass transfer coefficients will vary at different lyophilization scales; hence, we present an approach to use appropriate factors while scaling-up from lab scale to commercial scale. As a result, one can predict commercial scale primary drying time based on these parameters. Additionally, the model-based approach presented in this study provides a process to monitor pharmaceutical product robustness and accidental process deviations during Lyophilization to support commercial supply chain continuity. The approach presented here provides a robust lyophilization scale-up strategy; and because of the simple and minimalistic approach, it will also be less capital intensive path with minimal use of expensive drug substance/active material.

Utilizing remote sensing data for modeling water and heat regimes of the Black Earth Region territory of the European Russia

NASA Astrophysics Data System (ADS)

Muzylev, Eugene; Startseva, Zoya; Uspensky, Alexander; Volkova, Elena; Uspensky, Sergey

2014-05-01

At present physical-mathematical modeling processes of water and heat exchange between vegetation covered land surfaces and atmosphere is the most appropriate method to describe peculiarities of water and heat regime formation for large territories. The developed model of such processes (Land Surface Model, LSM) is intended for calculation evaporation, transpiration by vegetation, soil water content and other water and heat regime characteristics, as well as distributions of the soil temperature and humidity in depth utilizing remote sensing data from satellites on land surface and meteorological conditions. The model parameters and input variables are the soil and vegetation characteristics and the meteorological characteristics, correspondingly. Their values have been determined from ground-based observations or satellite-based measurements by radiometers AVHRR/NOAA, MODIS/EOS Terra and Aqua, SEVIRI/Meteosat-9, -10. The case study has been carried out for the part of the agricultural Central Black Earth region with coordinates 49.5 deg. - 54 deg. N, 31 deg. - 43 deg. E and a total area of 227,300 km2 located in the steppe-forest zone of the European Russia for years 2009-2012 vegetation seasons. From AVHRR data there have been derived the estimates of three types of land surface temperature (LST): land surface skin temperature Tsg, air-foliage temperature Ta and efficient radiation temperature Ts.eff, emissivity E, normalized vegetation index NDVI, vegetation cover fraction B, leaf area index LAI, cloudiness and precipitation. From MODIS data the estimates of LST Tls, E, NDVI and LAI have been obtained. The SEVIRI data have been used to build the estimates of Tls, Ta, E, LAI and precipitation. Previously developed method and technology of above AVHRR-derived estimates have been improved and adapted to the study area. To check the reliability of the Ts.eff and Ta estimations for named seasons the error statistics of their definitions has been analyzed through comparison with data of observations at agricultural meteorological stations of the study region. The mentioned MODIS-based remote sensing products for the same vegetation seasons have been built using data downloaded from the website LP DAAC (NASA). Reliability of the MODIS-derived Tls estimates have been confirmed by results of comparison with similar estimates from synchronous AVHRR, SEVIRI and ground-based data. To retrieve Tls and E from SEVIRI data at daylight and nighttime there have been developed the method and technology of thematic processing these data in IR channels NN 9, 10 (10.8 and 12.0 nm) at three successive times under cloud-free conditions without using exact values of E. This technology has been also adapted to the study area. Analysis of reliability of Tls estimation have been carried out through comparing with synchronous SEVIRI-derived Tls estimates obtained at Land Surface Analysis Satellite Applications Facility (LSA SAF, Lisbon, Portugal) and MODIS-derived Tls estimates. When the first comparison daily - or monthly-averaged values of RMS deviation have not been exceeded 2 deg. C for various dates and months during years 2009-2012 vegetation seasons. RMS deviation of Tls(SEVIRI) from Tls(MODIS) has been in the range of 1.0-3.0 deg. C. The method and technology have been also developed and tested to define Ta values from SEVIRI data at daylight and nighttime. This method is based on using satellite-derived estimates of Tls and regression relationship between Tls and ground-measured values of Ta. Comparison of satellite-based Ta estimates with data of synchronous standard term ground-based observations at the network of meteorological stations of the study area for summer periods of 2009-2012 has given RMS deviation values in the range of 1.8-3.0 deg. C. Formed archive of satellite products has been also supplemented with array of LAI estimates retrieved from SEVIRI data at LSA SAF for the study area and growing seasons 2011-2012. The possibility is shown to use the developed Multi Threshold Method (MTM) for generating the AVHRR- and SEVIRI-based estimates of daily and monthly precipitation amounts for the region of interest The MTM provides the cloud detection and identification of cloud types, estimation of the maximum liquid water content and cloud layer water content, allocation of precipitation zones and determination of instantaneous maximum of precipitation intensities in the pixel range around the clock throughout the year independently of the land surface type. In developing procedures of utilizing satellite estimates of precipitation during the vegetation season in the model there have been built up algorithms and programs of transition from estimating the rainfall intensity to assessment of their daily values. The comparison of the daily, monthly and seasonal AVHRR- and SEVIRI-derived precipitation sums with similar values retrieved from network ground-based observations using weighting interpolation procedure have been carried out. Agreement of all three evaluations is satisfactory. To assimilate remote sensing products into the model the special techniques have been developed including: 1) replacement of ground-measured model parameters LAI and B by their satellite-derived estimates. The possibility of such replacement has been confirmed through various comparisons of: a) LAI behavior for ground- and satellite-derived values; b) modeled values of Ts and Tf , satellite-based estimates of Ts.eff, Tls and Ta and ground-based measurements of LST; c) modeled and measured values of soil water content W and evapotranspiration Ev; 2) utilization of satellite-derived values of LSTs Ts.eff, Tls and Ta, and estimates of precipitation as the input model variables instead of the respective ground-measured temperatures and rainfall when assessing the accuracy of soil water content, evapotranspiration and soil temperature calculations; 3) accounting for the spatial variability of satellite-based LAI, B, LST and precipitation estimates by entering their area-distributed values into the model. For years 2009-2012 vegetation seasons there have been calculated the characteristics of the water and heat regimes of the region under investigation utilizing satellite estimates of vegetation characteristics, LST and precipitation in the model. The calculation results have shown that the discrepancies of evapotranspiration and soil water content values are within acceptable limits.

Effects of radiofrequency probe application on irrigation fluid temperature in the wrist joint.

PubMed

Sotereanos, Dean G; Darlis, Nickolaos A; Kokkalis, Zinon T; Zanaros, George; Altman, Gregory T; Miller, Mark Carl

2009-12-01

Radiofrequency (RF) probes used in wrist arthroscopy may raise joint fluid temperature, increasing the risk of capsular and ligamentous damage. The purposes of the current study were to measure joint fluid temperature during wrist arthroscopy with the use of RF probes, and to determine whether using an outlet portal will reduce the maximum temperature. We performed wrist arthroscopy on 8 cadaveric arms. Ablation and coagulation cycles using RF probe were performed at documented locations within the joint. This was done for 60-second intervals on both the radial and ulnar side of the wrist, to mimic clinical practice. We used 4 fiberoptic phosphorescent probes to measure temperature (radial, ulnar, inflow-tube, and outflow-tube probes) and measured joint fluid temperature with and without outflow. There was a significant difference between wrists with and without outflow when examining maximum ablation temperatures (p < .002). All specimens showed higher maximum and average ablation temperatures without outflow. Maximum joint temperatures, greater than 60 degrees C, were observed in only no-outflow conditions. In performing RF ablation during wrist arthroscopy, the use of an outlet portal reduces the joint fluid temperature. Without an outlet portal, maximum temperatures can exceed desirable levels when using ablation; such temperatures have the potential to damage adjacent tissues. It is useful to maintain adequate outflow when using the radiofrequency probes during wrist arthroscopy.

Soil and air temperatures for different habitats in Mount Rainier National Park.

Treesearch

Sarah E. Greene; Mark Klopsch

1985-01-01

This paper reports air and soil temperature data from 10 sites in Mount Rainier National Park in Washington State for 2- to 5-year periods. Data provided are monthly summaries for day and night mean air temperatures, mean minimum and maximum air temperatures, absolute minimum and maximum air temperatures, range of air temperatures, mean soil temperature, and absolute...

The coronal structure of active regions

NASA Technical Reports Server (NTRS)

Landini, M.; Monsignori Fossi, B. C.; Krieger, A.; Vaiana, G. S.

1975-01-01

A four-parameter model, which assumes a Gaussian dependence of both temperature and pressure on distance from center, is used to fit the compact part of coronal active regions as observed in X-ray photographs from a rocket experiment. The four parameters are the maximum temperature, the maximum pressure, the width of the pressure distribution, and the width of the temperature distribution. The maximum temperature ranges from 2.2 to 2.8 million K, and the maximum density from 2 to 9 by 10 to the 9th power per cu cm. The range of the pressure-distribution width is from 2 to 4 by 10 to the 9th power cm and that of the temperature-distribution width from 2 to 7.

Changes in minimum and maximum temperatures at the Pic du Midi in relation with humidity and cloudiness, 1882-1984

NASA Astrophysics Data System (ADS)

Dessens, J.; Bücher, A.

In an attempt to contribute to the investigation on a global climate change, a historical series of minimum and maximum temperature data at the Pic du Midi, a mountain observatory at 2862 m a.s.l. in the French Pyrenees, is updated after correction of a systematic deviation due to a relocation of the station in 1971. These data, which now cover the 1882-1984 period, are examined in parallel with humidity and cloud cover data for the same period. From the beginning to the end of this period, observations show that the mean night-time temperature has increased by 2.39° C/100 yr while the mean daytime temperature has decreased by 0.50° C/100 yr. In consequence, the mean annual diurnal temperature range has dropped by 36%/100 yr. The maximum seasonal decrease is 46%/100 yr in spring. Season-to-season and year-to-year inter-relationships between minimum temperature, maximum temperature, relative humidity and cloud cover suggest that the decrease in maximum temperature is related to a concomitant increase of 15%/100 yr in both relative humidity and cloud cover.

Increases in maximum stream temperatures after slash burning in a small experimental watershed.

Treesearch

Al Levno; Jack Rothacher

1969-01-01

The first year after slash was burned on a 237-acre clearcut watershed in the Cascade Range of Oregon, average maximum water temperatures increased 13°, 14°, and 12°F, during June, July, and August. A maximum stream temperature of 75°F. persisted for 3 hours on a day in July.

Determination of the Maximum Temperature in a Non-Uniform Hot Zone by Line-of-Site Absorption Spectroscopy with a Single Diode Laser.

PubMed

Liger, Vladimir V; Mironenko, Vladimir R; Kuritsyn, Yurii A; Bolshov, Mikhail A

2018-05-17

A new algorithm for the estimation of the maximum temperature in a non-uniform hot zone by a sensor based on absorption spectrometry with a diode laser is developed. The algorithm is based on the fitting of the absorption spectrum with a test molecule in a non-uniform zone by linear combination of two single temperature spectra simulated using spectroscopic databases. The proposed algorithm allows one to better estimate the maximum temperature of a non-uniform zone and can be useful if only the maximum temperature rather than a precise temperature profile is of primary interest. The efficiency and specificity of the algorithm are demonstrated in numerical experiments and experimentally proven using an optical cell with two sections. Temperatures and water vapor concentrations could be independently regulated in both sections. The best fitting was found using a correlation technique. A distributed feedback (DFB) diode laser in the spectral range around 1.343 µm was used in the experiments. Because of the significant differences between the temperature dependences of the experimental and theoretical absorption spectra in the temperature range 300⁻1200 K, a database was constructed using experimentally detected single temperature spectra. Using the developed algorithm the maximum temperature in the two-section cell was estimated with accuracy better than 30 K.

Estimation of Surface Air Temperature from MODIS 1km Resolution Land Surface Temperature Over Northern China

NASA Technical Reports Server (NTRS)

Shen, Suhung; Leptoukh, Gregory G.; Gerasimov, Irina

2010-01-01

Surface air temperature is a critical variable to describe the energy and water cycle of the Earth-atmosphere system and is a key input element for hydrology and land surface models. It is a very important variable in agricultural applications and climate change studies. This is a preliminary study to examine statistical relationships between ground meteorological station measured surface daily maximum/minimum air temperature and satellite remotely sensed land surface temperature from MODIS over the dry and semiarid regions of northern China. Studies were conducted for both MODIS-Terra and MODIS-Aqua by using year 2009 data. Results indicate that the relationships between surface air temperature and remotely sensed land surface temperature are statistically significant. The relationships between the maximum air temperature and daytime land surface temperature depends significantly on land surface types and vegetation index, but the minimum air temperature and nighttime land surface temperature has little dependence on the surface conditions. Based on linear regression relationship between surface air temperature and MODIS land surface temperature, surface maximum and minimum air temperatures are estimated from 1km MODIS land surface temperature under clear sky conditions. The statistical errors (sigma) of the estimated daily maximum (minimum) air temperature is about 3.8 C(3.7 C).

Commercial products to preserve specimens for tuberculosis diagnosis: a systematic review.

PubMed

Reeve, B W P; McFall, S M; Song, R; Warren, R; Steingart, K R; Theron, G

2018-07-01

Eliminating tuberculosis in high-burden settings requires improved diagnostic capacity. Important tests such as Xpert® MTB/RIF and culture are often performed at centralised laboratories that are geographically distant from the point of specimen collection. Preserving specimen integrity during transportation, which could affect test performance, is challenging. To conduct a systematic review of commercial products for specimen preservation for a World Health Organization technical consultation. Databases were searched up to January 2018. Methodological quality was assessed using Quality Assessment of Technical Studies, a new technical study quality-appraisal tool, and Quality Assessment of Diagnostic Accuracy Studies-2. Studies were analysed descriptively in terms of the different products, study designs and diagnostic strategies used. Four products were identified from 16 studies: PrimeStore-Molecular-Transport-Medium (PS-MTM), FTA card, GENO•CARD (all for nucleic acid amplification tests [NAATs]) and OMNIgene•SPUTUM (OMS; culture, NAATs). PS-MTM, but not FTA card or GENO•CARD, rendered Mycobacterium tuberculosis non-culturable. OMS reduced Löwenstein-Jensen but not MGIT™ 960™ contamination, led to delayed MGIT time-to-positivity, resulted in Xpert performance similar to cold chain-transported untreated specimens, and obviated the need for N-acetyl-L-cysteine-sodium hydroxide decontamination. Data from paucibacillary specimens were limited. Evidence that a cold chain improves culture was mixed and absent for Xpert. The effect of the product alone could be discerned in only four studies. Limited evidence suggests that transport products result in test performance comparable to that seen in cold chain-transported specimens.

Three-year financial analysis of pharmacy services at an independent community pharmacy.

PubMed

Doucette, William R; McDonough, Randal P; Mormann, Megan M; Vaschevici, Renata; Urmie, Julie M; Patterson, Brandon J

2012-01-01

To assess the financial performance of pharmacy services including vaccinations, cholesterol screenings, medication therapy management (MTM), adherence management services, employee health fairs, and compounding services provided by an independent community pharmacy. Three years (2008-10) of pharmacy records were examined to determine the total revenue and costs of each service. Costs included products, materials, labor, marketing, overhead, equipment, reference materials, and fax/phone usage. Costs were allocated to each service using accepted principles (e.g., time for labor). Depending on the service, the total revenue was calculated by multiplying the frequency of the service by the revenue per patient or by adding the total revenue received. A sensitivity analysis was conducted for the adherence management services to account for average dispensing net profit. 7 of 11 pharmacy services showed a net profit each year. Those services include influenza and herpes zoster immunization services, MTM, two adherence management services, employee health fairs, and prescription compounding services. The services that realized a net loss included the pneumococcal immunization service, cholesterol screenings, and two adherence management services. The sensitivity analysis showed that all adherence services had a net gain when average dispensing net profit was included. Most of the pharmacist services had an annual positive net gain. It seems likely that these services can be sustained. Further cost management, such as reducing labor costs, could improve the viability of services with net losses. However, even with greater efficiency, external factors such as competition and reimbursement challenge the sustainability of these services.

The paradox of pharmacy: A profession's house divided.

PubMed

Brown, Daniel

2012-01-01

To describe the paradox in pharmacy between the vision of patient care and the reality of community pharmacy practice and to explore how integrated reimbursement for the retail prescription and linking cognitive patient care services directly to prescription processing could benefit the profession. A dichotomy exists between what many pharmacists do and what they've been trained to do. Pharmacy leaders have formulated a vision for pharmacists to become more involved in direct patient care. All graduates now receive PharmD-level training, and some leaders call for requirements of postgraduate residency training and board certification for pharmacists who provide patient care. How such requirements would relate to community pharmacy practice is unclear. The retail prescription remains the primary link between the pharmacist and the health care consumer. Cognitive services, such as medication therapy management (MTM), need to be integrated into the standard workflow of community pharmacies so as to become a natural extension of the professional services rendered in the process of filling a prescription. Current prescription fees are not sufficient to support legitimate professional services. A proposed integrated pricing system for retail prescriptions includes a $15 professional fee that is scaled upward for value-added services, such as MTM. Pharmacy includes a diversity of practice that has historically been a source of division. For pharmacists to reach their potential as patient care providers, the various factions within the profession must forge a unified vision of the future that addresses all realms of practice.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Viola, M. E.; Brown, T.; Heitzenroeder, P.

The National Compact Stellarator Experiment (NCSX) is being constructed at the Princeton Plasma Physics Laboratory (PPPL) in conjunction with the Oak Ridge National Laboratory (ORNL). The goal of this experiment is to develop a device which has the steady state properties of a traditional stellarator along with the high performance characteristics of a tokamak. A key element of this device is its highly shaped Inconel 625 vacuum vessel. This paper describes the manufacturing of the vessel. The vessel is being fabricated by Major Tool and Machine, Inc. (MTM) in three identical 120º vessel segments, corresponding to the three NCSX fieldmore » periods, in order to accommodate assembly of the device. The port extensions are welded on, leak checked, cut off within 1" of the vessel surface at MTM and then reattached at PPPL, to accommodate assembly of the close-fitting modular coils that surround the vessel. The 120º vessel segments are formed by welding two 60º segments together. Each 60º segment is fabricated by welding ten press-formed panels together over a collapsible welding fixture which is needed to precisely position the panels. The vessel is joined at assembly by welding via custom machined 8" (20.3 cm) wide spacer "spool pieces." The vessel must have a total leak rate less than 5 X 10-6 t-l/s, magnetic permeability less than 1.02μ, and its contours must be within 0.188" (4.76 mm). It is scheduled for completion in January 2006.« less

Analysis of temperature trends in Northern Serbia

NASA Astrophysics Data System (ADS)

Tosic, Ivana; Gavrilov, Milivoj; Unkašević, Miroslava; Marković, Slobodan; Petrović, Predrag

2017-04-01

An analysis of air temperature trends in Northern Serbia for the annual and seasonal time series is performed for two periods: 1949-2013 and 1979-2013. Three data sets of surface air temperatures: monthly mean temperatures, monthly maximum temperatures, and monthly minimum temperatures are analyzed at 9 stations that have altitudes varying between 75 m and 102 m. Monthly mean temperatures are obtained as the average of the daily mean temperatures, while monthly maximum (minimum) temperatures are the maximum (minimum) values of daily temperatures in corresponding month. Positive trends were found in 29 out of 30 time series, and the negative trend was found only in winter during the period 1979-2013. Applying the Mann-Kendall test, significant positive trends were found in 15 series; 7 in the period 1949-2013 and 8 in the period 1979-2013; and no significant trend was found in 15 series. Significant positive trends are dominated during the year, spring, and summer, where it was found in 14 out of 18 cases. Significant positive trends were found 7, 5, and 3 times in mean, maximum and minimum temperatures, respectively. It was found that the positive temperature trends are dominant in Northern Serbia.

A basin-scale approach to estimating stream temperatures of tributaries to the lower Klamath River, California

USGS Publications Warehouse

Flint, L.E.; Flint, A.L.

2008-01-01

Stream temperature is an important component of salmonid habitat and is often above levels suitable for fish survival in the Lower Klamath River in northern California. The objective of this study was to provide boundary conditions for models that are assessing stream temperature on the main stem for the purpose of developing strategies to manage stream conditions using Total Maximum Daily Loads. For model input, hourly stream temperatures for 36 tributaries were estimated for 1 Jan. 2001 through 31 Oct. 2004. A basin-scale approach incorporating spatially distributed energy balance data was used to estimate the stream temperatures with measured air temperature and relative humidity data and simulated solar radiation, including topographic shading and corrections for cloudiness. Regression models were developed on the basis of available stream temperature data to predict temperatures for unmeasured periods of time and for unmeasured streams. The most significant factor in matching measured minimum and maximum stream temperatures was the seasonality of the estimate. Adding minimum and maximum air temperature to the regression model improved the estimate, and air temperature data over the region are available and easily distributed spatially. The addition of simulated solar radiation and vapor saturation deficit to the regression model significantly improved predictions of maximum stream temperature but was not required to predict minimum stream temperature. The average SE in estimated maximum daily stream temperature for the individual basins was 0.9 ?? 0.6??C at the 95% confidence interval. Copyright ?? 2008 by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America. All rights reserved.

Mobile Health Technology Using a Wearable Sensorband for Female College Students With Problem Drinking: An Acceptability and Feasibility Study.

PubMed

Leonard, Noelle Regina; Silverman, Michelle; Sherpa, Dawa Phuti; Naegle, Madeline A; Kim, Hyorim; Coffman, Donna L; Ferdschneider, Marcy

2017-07-07

An increasing number of mobile app interventions have been developed for problem drinking among college students; however, few studies have examined the integration of a mobile app with continuous physiological monitoring and alerting of affective states related to drinking behaviors. The aim of this paper was to evaluate the acceptability and feasibility of Mind the Moment (MtM), a theoretically based intervention for female college students with problem drinking that combines brief, in-person counseling with ecological momentary intervention (EMI) on a mobile app integrated with a wearable sensorband. We recruited 10 non-treatment seeking, female undergraduates from a university health clinic who scored a 3 or higher on the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) to participate in this pilot study. Study activities involved an in-person baseline intake and 1 follow-up assessment, 2 in-person alcohol brief intervention counseling sessions, and use of MtM technology components (sensorband and EMI on a mobile app) for approximately 3-4 weeks. The intervention used motivational interviewing (MI) and cognitive behavioral therapy (CBT) strategies for reducing risks associated with drinking. We used both qualitative and quantitative assessments to measure acceptability of the intervention and feasibility of delivery. Use patterns of the sensorband and mobile app were also collected. Quantitative and qualitative data indicated high levels of acceptability for the MtM intervention. Altogether, participants made reports on the app on 26.7% (78/292) the days the technology was available to them and completed a total of 325 reports with wide variation between participants. Qualitative findings indicated that sensorband-elicited alerts promoted an increase in awareness of thoughts, feelings, and behaviors related to current environmental stressors and drinking behaviors in theoretically meaningful ways. Specific challenges related to functionality and form of the sensorband were identified. Delivering intervention material "just-in-time," at the moment participants need to use behavioral strategies has great potential to individualize behavioral interventions for reducing problem drinking and other health behaviors. These findings provide initial evidence for the promise of wearable sensors for increasing potency of theoretically grounded mobile health interventions and point to directions for future research and uptake of these technologies. ©Noelle Regina Leonard, Michelle Silverman, Dawa Phuti Sherpa, Madeline A Naegle, Hyorim Kim, Donna L Coffman, Marcy Ferdschneider. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 07.07.2017.

Thermal Modelling Analysis of Spiral Wound Supercapacitor under Constant-Current Cycling

PubMed Central

Wang, Kai; Li, Liwei; Yin, Huaixian; Zhang, Tiezhu; Wan, Wubo

2015-01-01

A three-dimensional modelling approach is used to study the effects of operating and ambient conditions on the thermal behaviour of the spiral wound supercapacitor. The transient temperature distribution during cycling is obtained by using the finite element method with an implicit predictor-multicorrector algorithm. At the constant current of 2A, the results show that the maximum temperature appears in core area. After 5 cycles, the maximum temperature is 34.5°C, while in steady state, it’s up to 42.5°C. This paper further studies the relationship between the maximum temperature and charge-discharge current. The maximum temperature will be more than 60°C after 5 cycles at the current of 4A, and cooling measurements should be taken at that time. It can provide thoughts on inner temperature field distribution and structure design of the spiral wound supercapacitor in working process. PMID:26444687

Effects of Pouring Temperature and Electromagnetic Stirring on Porosity and Mechanical Properties of A357 Aluminum Alloy Rheo-Diecasting

NASA Astrophysics Data System (ADS)

Guo, An; Zhao, Junwen; Xu, Chao; Li, Hu; Han, Jing; Zhang, Xu

2018-05-01

Semisolid slurry of A357 aluminum alloy was prepared using a temperature-controllable electromagnetic stirrer and rheo-diecast at different temperatures. The effects of pouring temperature and electromagnetic stirring (EMS) on the porosity in rheo-diecast samples, as well as the relation between porosity and mechanical properties, were investigated. The results show that pouring temperature and EMS had minor influences on rheo-diecast microstructure but marked influence on the porosity. With decreasing slurry pouring temperature, the porosity decreased first and then increased, whereas the maximum pore ratio (ratio of shape factor to diameter of the largest pore) increased first and then decreased. The maximum pore ratio determines the level of tensile strength and elongation, and higher mechanical properties can be obtained with smaller and rounder pores in samples. The mechanical properties of the rheo-diecast samples increased linearly with increasing maximum pore ratio. The maximum pore ratio was 1.43 µm-1, and the minimum porosity level was 0.37% under EMS condition for the rheo-diecast samples obtained at a pouring temperature of 608 °C. With this porosity condition, the maximum tensile strength and elongation were achieved at 274 MPa and 4.9%, respectively. It was also revealed that EMS improves mechanical properties by reduction in porosity and an increase in maximum pore ratio.

Temperature and pressure influence on maximum rates of pressure rise during explosions of propane-air mixtures in a spherical vessel.

PubMed

Razus, D; Brinzea, V; Mitu, M; Movileanu, C; Oancea, D

2011-06-15

The maximum rates of pressure rise during closed vessel explosions of propane-air mixtures are reported, for systems with various initial concentrations, pressures and temperatures ([C(3)H(8)]=2.50-6.20 vol.%, p(0)=0.3-1.3 bar; T(0)=298-423 K). Experiments were performed in a spherical vessel (Φ=10 cm) with central ignition. The deflagration (severity) index K(G), calculated from experimental values of maximum rates of pressure rise is examined against the adiabatic deflagration index, K(G, ad), computed from normal burning velocities and peak explosion pressures. At constant temperature and fuel/oxygen ratio, both the maximum rates of pressure rise and the deflagration indices are linear functions of total initial pressure, as reported for other fuel-air mixtures. At constant initial pressure and composition, the maximum rates of pressure rise and deflagration indices are slightly influenced by the initial temperature; some influence of the initial temperature on maximum rates of pressure rise is observed only for propane-air mixtures far from stoichiometric composition. The differentiated temperature influence on the normal burning velocities and the peak explosion pressures might explain this behaviour. Copyright © 2011 Elsevier B.V. All rights reserved.

Change in mean temperature as a predictor of extreme temperature change in the Asia-Pacific region

NASA Astrophysics Data System (ADS)

Griffiths, G. M.; Chambers, L. E.; Haylock, M. R.; Manton, M. J.; Nicholls, N.; Baek, H.-J.; Choi, Y.; della-Marta, P. M.; Gosai, A.; Iga, N.; Lata, R.; Laurent, V.; Maitrepierre, L.; Nakamigawa, H.; Ouprasitwong, N.; Solofa, D.; Tahani, L.; Thuy, D. T.; Tibig, L.; Trewin, B.; Vediapan, K.; Zhai, P.

2005-08-01

Trends (1961-2003) in daily maximum and minimum temperatures, extremes and variance were found to be spatially coherent across the Asia-Pacific region. The majority of stations exhibited significant trends: increases in mean maximum and mean minimum temperature, decreases in cold nights and cool days, and increases in warm nights. No station showed a significant increase in cold days or cold nights, but a few sites showed significant decreases in hot days and warm nights. Significant decreases were observed in both maximum and minimum temperature standard deviation in China, Korea and some stations in Japan (probably reflecting urbanization effects), but also for some Thailand and coastal Australian sites. The South Pacific convergence zone (SPCZ) region between Fiji and the Solomon Islands showed a significant increase in maximum temperature variability.Correlations between mean temperature and the frequency of extreme temperatures were strongest in the tropical Pacific Ocean from French Polynesia to Papua New Guinea, Malaysia, the Philippines, Thailand and southern Japan. Correlations were weaker at continental or higher latitude locations, which may partly reflect urbanization.For non-urban stations, the dominant distribution change for both maximum and minimum temperature involved a change in the mean, impacting on one or both extremes, with no change in standard deviation. This occurred from French Polynesia to Papua New Guinea (except for maximum temperature changes near the SPCZ), in Malaysia, the Philippines, and several outlying Japanese islands. For urbanized stations the dominant change was a change in the mean and variance, impacting on one or both extremes. This result was particularly evident for minimum temperature.The results presented here, for non-urban tropical and maritime locations in the Asia-Pacific region, support the hypothesis that changes in mean temperature may be used to predict changes in extreme temperatures. At urbanized or higher latitude locations, changes in variance should be incorporated.

Influence of stream characteristics and grazing intensity on stream temperatures in eastern Oregon.

Treesearch

S.B. Maloney; A.R. Tiedemann; D.A. Higgins; T.M. Quigley; D.B. Marx

1999-01-01

Stream temperatures were measured during summer months, 1978 to 1984, at 12 forested watersheds near John Day, Oregon, to determine temperature characteristics and assess effects of three range management strategies of increasing intensity. Maximum temperatures in streams of the 12 watersheds ranged from 12.5 to 27.8 oC. Maximum stream temperatures on four watersheds...

14 CFR 23.1521 - Powerplant limitations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... reciprocating engines); (3) The maximum allowable gas temperature (for turbine engines); (4) The time limit for... maximum allowable gas temperature (for turbine engines); and (4) The maximum allowable cylinder head, oil... reciprocating engines), or fuel designation (for turbine engines), must be established so that it is not less...

14 CFR 23.1521 - Powerplant limitations.

Code of Federal Regulations, 2013 CFR

2013-01-01

... reciprocating engines); (3) The maximum allowable gas temperature (for turbine engines); (4) The time limit for... maximum allowable gas temperature (for turbine engines); and (4) The maximum allowable cylinder head, oil... reciprocating engines), or fuel designation (for turbine engines), must be established so that it is not less...

14 CFR 23.1521 - Powerplant limitations.

Code of Federal Regulations, 2012 CFR

2012-01-01

... reciprocating engines); (3) The maximum allowable gas temperature (for turbine engines); (4) The time limit for... maximum allowable gas temperature (for turbine engines); and (4) The maximum allowable cylinder head, oil... reciprocating engines), or fuel designation (for turbine engines), must be established so that it is not less...

14 CFR 23.1521 - Powerplant limitations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... reciprocating engines); (3) The maximum allowable gas temperature (for turbine engines); (4) The time limit for... maximum allowable gas temperature (for turbine engines); and (4) The maximum allowable cylinder head, oil... reciprocating engines), or fuel designation (for turbine engines), must be established so that it is not less...

14 CFR 23.1521 - Powerplant limitations.

Code of Federal Regulations, 2014 CFR

2014-01-01

... reciprocating engines); (3) The maximum allowable gas temperature (for turbine engines); (4) The time limit for... maximum allowable gas temperature (for turbine engines); and (4) The maximum allowable cylinder head, oil... reciprocating engines), or fuel designation (for turbine engines), must be established so that it is not less...

Temperature changes in dental implants following exposure to hot substances in an ex vivo model.

PubMed

Feuerstein, Osnat; Zeichner, Kobi; Imbari, Chen; Ormianer, Zeev; Samet, Nachum; Weiss, Ervin I

2008-06-01

The habitual consumption of extremely hot foods and beverages may affect implant treatment modality. Our objectives were to: (i) establish the maximum temperature produced intra-orally while consuming very hot substances and (ii) use these values in an ex vivo model to assess the temperature changes along the implant-bone interface. Temperatures were measured using thermocouples linked to a computer. The thermocouple electrodes were attached to the tooth-gum interface of the interproximal areas in 14 volunteers during consumption of extremely hot foods and beverages. The in vivo measured temperature values obtained were used in an ex vivo model of a bovine mandible block with an implant and with an assembled abutment. Temperatures were measured by thermocouple electrodes attached to five locations, three of them along the implant-bone interface. During consumption of a hot beverage, a maximum temperature of up to 76.3 degrees C was recorded, and a calculated extreme intra-oral temperature of 61.4 degrees C was established. The ex vivo model showed a high correlation between the temperature measured at the abutment and that measured at the abutment-implant interface and inside the implant, reaching maximum temperatures close to 60 degrees C. At the mid-implant-bone and apical implant-bone interfaces, the maximum temperatures measured were 43.3 and 42 degrees C, respectively. The maximum temperatures measured at the implant-bone interfaces reached the temperature threshold of transient changes in bone (42 degrees C). The results of this study support the notion that intra-oral temperatures, developed during the consumption of very hot substances, may be capable of damaging peri-implant tissues.

Drug & Gene Interaction Risk Analysis With & Without Genetic Testing Among Patients Undergoing MTM

ClinicalTrials.gov

2017-02-22

Cytochrome P450 CYP2D6 Enzyme Deficiency; Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant; Ultrarapid Metabolizer Due to Cytochrome P450 CYP2D6 Variant; Extensive Metabolizer Due to Cytochrome P450 CYP2D6 Variant; Cytochrome P450 CYP2C9 Enzyme Deficiency; Cytochrome P450 CYP2C19 Enzyme Deficiency; Drug Metabolism, Poor, CYP2D6-RELATED; Drug Metabolism, Poor, CYP2C19-RELATED; CYP2D6 Polymorphism

One New Method to Generate 3-Dimensional Virtual Mannequin

NASA Astrophysics Data System (ADS)

Xiu-jin, Shi; Zhi-jun, Wang; Jia-jin, Le

The personal virtual mannequin is very important in electronic made to measure (eMTM) system. There is one new easy method to generate personal virtual mannequin. First, the characteristic information of customer's body is got from two photos. Secondly, some human body part templates corresponding with the customer are selected from the templates library. Thirdly, these templates are modified and assembled according to certain rules to generate a personalized 3-dimensional human, and then the virtual mannequin is realized. Experimental result shows that the method is easy and feasible.

Patterns of Food Utilization in the DOD. Volume 2

DTIC Science & Technology

1975-05-01

DOD .on .213 81.540 ROLLS faROWN/SERVE DOD .014 .213 81.752 COOKIES VANILLA WAFER DOD .014 .210 81.963 SWEET DOUGH MIX DOD .014 .209 82.172 PEACHES...ROASTED COOKIE MIX OATiEAL SERVICE USACVRATION DOD .0C2 DOD .003 DOD .00307 DOD .00002 DOD .008 DOD .001 DO" .005 POD .0004 DOD .002 DOD .001...M.,lin.mtm^.,m,mtff»m. -~——-^.-P-~—~ iwmmm^* m u ITEM COOKIES V’MILL» WAFER CCRN BREAD MIX CORN CHIPS CORN CREAM STYLE CND CORK

Medical Surveillance Monthly Report (MSMR). Volume 19, Number 2, February 2012

DTIC Science & Technology

2012-02-01

Health Surveillance Center CAPT Kevin L. Russell, MD, MTM &H, FIDSA (USN) Editor Francis L. O’Donnell, MD, MPH Contributing Former Editor John F ...S U M M A R Y T A B L E S A N D F I G U R E S P A G E 2 4 Deployment-related conditions of special surveillance interest Nancy A. Skopp, PhD...proximity to their suicides; an esti- mated 45 percent of individuals with com- pleted suicides had encounters with health care providers within one

Non-trivial behavior of the low temperature maximum of dielectric constant and location of the end critical point in Na0.5Bi0.5TiO3-0.06BaTiO3 lead free relaxor ferroelectrics crystals detected by acoustic emission

NASA Astrophysics Data System (ADS)

Dul'kin, Evgeniy; Tiagunova, Jenia; Mojaev, Evgeny; Roth, Michael

2018-01-01

[001] lead free relaxor ferroelectrics crystals of Na0.5Bi0.5TiO3-0.06BaTiO3 were studied by means of dielectric and acoustic emission methods in the temperature range of 25-240 °C and under a dc bias electric field up to 0.4 kV/cm. A temperature maximum of the dielectric constant was found near 170 °C, as well as the acoustic emission bursts pointed out to both the depolarization temperature near 120 °C and the temperature, corresponding to the maximum of dielectric constant, near 170 °C. While the depolarization temperature increased linearly, the temperature of the dielectric constant maximum was shown to exhibit a V-shape behavior under an electric field: it initially decreases, reaches a sharp minimum at some small threshold electric field of 0.15 kV/cm, and then starts to increase similar to the Curie temperature of the normal ferroelectrics, as the field enhances. Acoustic emission bursts, accompanying the depolarization temperature, weakened with the enhancing field, whereas the ones accompanying the temperature of the dielectric constant maximum exhibited two maxima: near 0.1 kV/cm and near 0.3 kV/cm. The meaning of these two acoustic emission maxima is discussed.

Fluid-inclusion technique for determining maximum temperature in calcite and its comparison to the vitrinite reflectance geothermometer

USGS Publications Warehouse

Barker, C.E.; Goldstein, R.H.

1990-01-01

The hypothesis that aqueous fluid inclusions in calcite can be used to establish maximum temperature (Tpeak) is tested. Fluid inclusion Th, mean random vitrinite reflectance (Rm), and present-day Tpeak from 46 diverse geologic systems that have been at Tpeak from 104 to 106 yr have been compiled. Present Tpeak ranged from 65 to 345??C, Th modes and means ranged from 59 to 350??C, and Rm data ranged from 0.4% to 4.6%, spanning the temperature and thermal maturity range associated with burial diagenesis, hydrothermal alteration, and low-grade metamorphism. Plots of Th and Tpeak data for systems thought to be currently at maximum temperature demonstrate close agreement between Th and present Tpeak in sedimentary basins. The relation suggests that Th of aqueous fluid inclusions in calcite may be a useful measure of maximum temperature. This study also compared Th to mean random vitrinite reflectance (Rm). Th correlates well with Rm and results in a curve similar to Rm vs. Tpeak calibrations determined by other workers. Strong correlation between Tpeak and Rm in these systems suggests that maximum temperature is the major control on thermal maturation. -after Authors

Modeling maximum daily temperature using a varying coefficient regression model

Treesearch

Han Li; Xinwei Deng; Dong-Yum Kim; Eric P. Smith

2014-01-01

Relationships between stream water and air temperatures are often modeled using linear or nonlinear regression methods. Despite a strong relationship between water and air temperatures and a variety of models that are effective for data summarized on a weekly basis, such models did not yield consistently good predictions for summaries such as daily maximum temperature...

A method for safety testing of radiofrequency/microwave-emitting devices using MRI.

PubMed

Alon, Leeor; Cho, Gene Y; Yang, Xing; Sodickson, Daniel K; Deniz, Cem M

2015-11-01

Strict regulations are imposed on the amount of radiofrequency (RF) energy that devices can emit to prevent excessive deposition of RF energy into the body. In this study, we investigated the application of MR temperature mapping and 10-g average specific absorption rate (SAR) computation for safety evaluation of RF-emitting devices. Quantification of the RF power deposition was shown for an MRI-compatible dipole antenna and a non-MRI-compatible mobile phone via phantom temperature change measurements. Validation of the MR temperature mapping method was demonstrated by comparison with physical temperature measurements and electromagnetic field simulations. MR temperature measurements alongside physical property measurements were used to reconstruct 10-g average SAR. The maximum temperature change for a dipole antenna and the maximum 10-g average SAR were 1.83°C and 12.4 W/kg, respectively, for simulations and 1.73°C and 11.9 W/kg, respectively, for experiments. The difference between MR and probe thermometry was <0.15°C. The maximum temperature change and the maximum 10-g average SAR for a cell phone radiating at maximum output for 15 min was 1.7°C and 0.54 W/kg, respectively. Information acquired using MR temperature mapping and thermal property measurements can assess RF/microwave safety with high resolution and fidelity. © 2014 Wiley Periodicals, Inc.

A Method for Safety Testing of Radiofrequency/Microwave-Emitting Devices Using MRI

PubMed Central

Alon, Leeor; Cho, Gene Y.; Yang, Xing; Sodickson, Daniel K.; Deniz, Cem M.

2015-01-01

Purpose Strict regulations are imposed on the amount of radiofrequency (RF) energy that devices can emit to prevent excessive deposition of RF energy into the body. In this study, we investigated the application of MR temperature mapping and 10-g average specific absorption rate (SAR) computation for safety evaluation of RF-emitting devices. Methods Quantification of the RF power deposition was shown for an MRI-compatible dipole antenna and a non–MRI-compatible mobile phone via phantom temperature change measurements. Validation of the MR temperature mapping method was demonstrated by comparison with physical temperature measurements and electromagnetic field simulations. MR temperature measurements alongside physical property measurements were used to reconstruct 10-g average SAR. Results The maximum temperature change for a dipole antenna and the maximum 10-g average SAR were 1.83° C and 12.4 W/kg, respectively, for simulations and 1.73° C and 11.9 W/kg, respectively, for experiments. The difference between MR and probe thermometry was <0.15° C. The maximum temperature change and the maximum 10-g average SAR for a cell phone radiating at maximum output for 15 min was 1.7° C and 0.54 W/kg, respectively. Conclusion Information acquired using MR temperature mapping and thermal property measurements can assess RF/microwave safety with high resolution and fidelity. PMID:25424724

Rock Magnetic Fabrics, Paleomagnetic Vectors, and Rock Magnetic Cyclostratigraphy of the Marcellus FM, Sunbury PA

NASA Astrophysics Data System (ADS)

Minguez, D. A.; Kodama, K. P.

2013-12-01

We present the preliminary results of a multi-faceted rock magnetic study conducted on 195 samples from the Oatka Creek member of the Marcellus formation, where it has been extracted from the subsurface as a drill core near Sunbury, PA. Samples were oriented based on bedding attitude observed within the core and were removed from the core at a spacing of ≈0.25 meters starting from the base (depth ≈ 500 meters) and spanning 51 meters of stratigraphic section. The results of measurements of the anisotropy of magnetic susceptibility (AMS) consistently demonstrate a nearly triaxial fabric with maximum principal axes clustering east-west and horizontal in geographic coordinates, nearly parallel to the direction of bedding strike. AMS minimum principal axes cluster near the pole to the bedding plane. Anisotropy of anhysteretic remanence (AAR) applied with a 100 mT peak field and a 97 μT bias field in 9 orientations demonstrates a markedly different fabric, with maximum principal axis clustering north-south and horizontal in geographic coordinates. Minimum principal axes of AAR cluster steeply (~60-70 degrees) to the west. The discrepancy between AAR and AMS fabrics likely indicates the AMS is dominated by paramagnetic clays, and thus may be interpreted as an east-west intersection lineation of clay particles dipping gently north or south. Paleomagnetic directions obtained using Alternating Field (AF) demagnetization in 5 mT steps up to 110 mT demonstrates a high coercivity remanence (>35 mT) with a south and shallow direction (D= 183.4 I=-14.7). This result is consistent with previous studies of the Marcellus formation and the Devonian Catskill red beds. Thermal demagnetization experiments demonstrate a similar magnetization removed by temperatures between 250 and 350 degrees Celsius, however, continued heating results in the acquisition of strong, inconsistent magnetizations likely the result of oxidizing iron sulfides. Thermal demagnetization of orthogonal partial ARMs applied in 100 mT and 50 mT peak fields was conducted on a subset of samples sealed in aluminum foil with alumina-silica cement to prevent oxidization. The results demonstrate that the low coercivity pARM is removed by 400 degrees Celsius and the high coercivity pARM, which is only 10% of the total remanence, is removed by 600 degrees Celsius. The results suggest the presence of low coercivity Fe sulfides and high coercivity magnetite. Lastly, time series analysis of bulk magnetic susceptibility using the Multi-Taper Method (MTM) demonstrates oscillations with a wavelength of 18 meters above the 99% confidence level with respect to the robust red noise. This wavelength may have a duration of 405 kyr given ancillary chronostratigraphic evidence.

On the impacts of computing daily temperatures as the average of the daily minimum and maximum temperatures

NASA Astrophysics Data System (ADS)

Villarini, Gabriele; Khouakhi, Abdou; Cunningham, Evan

2017-12-01

Daily temperature values are generally computed as the average of the daily minimum and maximum observations, which can lead to biases in the estimation of daily averaged values. This study examines the impacts of these biases on the calculation of climatology and trends in temperature extremes at 409 sites in North America with at least 25 years of complete hourly records. Our results show that the calculation of daily temperature based on the average of minimum and maximum daily readings leads to an overestimation of the daily values of 10+ % when focusing on extremes and values above (below) high (low) thresholds. Moreover, the effects of the data processing method on trend estimation are generally small, even though the use of the daily minimum and maximum readings reduces the power of trend detection ( 5-10% fewer trends detected in comparison with the reference data).

Calculation of change in brain temperatures due to exposure to a mobile phone

NASA Astrophysics Data System (ADS)

Van Leeuwen, G. M. J.; Lagendijk, J. J. W.; Van Leersum, B. J. A. M.; Zwamborn, A. P. M.; Hornsleth, S. N.; Kotte, A. N. T. J.

1999-10-01

In this study we evaluated for a realistic head model the 3D temperature rise induced by a mobile phone. This was done numerically with the consecutive use of an FDTD model to predict the absorbed electromagnetic power distribution, and a thermal model describing bioheat transfer both by conduction and by blood flow. We calculated a maximum rise in brain temperature of 0.11 °C for an antenna with an average emitted power of 0.25 W, the maximum value in common mobile phones, and indefinite exposure. Maximum temperature rise is at the skin. The power distributions were characterized by a maximum averaged SAR over an arbitrarily shaped 10 g volume of approximately 1.6 W kg-1. Although these power distributions are not in compliance with all proposed safety standards, temperature rises are far too small to have lasting effects. We verified our simulations by measuring the skin temperature rise experimentally. Our simulation method can be instrumental in further development of safety standards.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ingham, J.G.

Maximum cladding temperatures occur when the IDENT 1578 fuel pin shipping container is installed in the T-3 Cask. The maximum allowable cladding temperature of 800/sup 0/F is reached when the rate of energy deposited in the 19-pin basket reaches 400 watts. Since 45% of the energy which is generated in the fuel escapes the 19-pin basket without being deposited, mostly gamma energy, the maximum allowable rate of heat generation is 400/.55 = 727 watts. Similarly, the maximum allowable cladding temperature of 800/sup 0/F is reached when the rate of energy deposited in the 40-pin basket reaches 465 watts. Since 33%more » of the energy which is generated in the fuel escapes the 40-pin basket without being deposited, mostly gamma energy, the maximum allowable rate of heat generation is 465/.66 = 704 watts. The IDENT 1578 fuel pin shipping container therefore meets its thermal design criteria. IDENT 1578 can handle fuel pins with a decay heat load of 600 watts while maintaining the maximum fuel pin cladding temperature below 800/sup 0/F. The emissivities which were determined from the test results for the basket tubes and container are relatively low and correspond to new, shiny conditions. As the IDENT 1578 container is exposed to high temperatures for extended periods of time during the transportation of fuel pins, the emissivities will probably increase. This will result in reduced temperatures.« less

On the location of the maximum homogeneous crystal nucleation temperature

NASA Technical Reports Server (NTRS)

Weinberg, Michael C.

1986-01-01

Detailed considerations are given to the location of the temperature of maximum homogeneous nucleation as predicted by classical nucleation theory. It is shown quite generally that this maximum temperature, T-asterisk, must occur above the Kauzmann temperature and that the T-asterisk is such that T-asterisk is greater than T(m)/3, where T(m) is the melting temperature. Also, it is demonstrated tha T-asterisk may be considered to be approximately dependent upon two parameters: gamma, the ratio of the difference in specific heat between the crystal and liquid divided by the entropy of fusion, and E, a reduced activation energy for viscous flow. The variation of T-asterisk with these parameters is described. The relationship of the relative location of T-asterisk to the glass transition temperature, is discussed too. This discussion is couched within the framework of the strong and fragile liquid notion introduced by Angell (1981) and coworkers. Finally, the question of the ultimate limits to the undercooling of liquid metals is considered and its relationhsip to computations of the maximum nucleation temperature in such systems.

Developing a diagnostic tool for measuring maximum effective temperature within high pressure electrodeless discharges

NASA Astrophysics Data System (ADS)

Whiting, Michael; Preston, Barry; Mucklejohn, Stuart; Santos, Monica; Lister, Graeme

2016-09-01

Here we present an investigation into the feasibility of creating a diagnostic tool for obtaining maximum arc temperature measurements within a high pressure electrodeless discharge; utilizing integrating sphere measurements of optically thin lines emitted from mercury atoms within commercially available high pressure mercury lamp arc tubes. The optically thin lines chosen were 577 nm and 1014 nm from a 250 W high pressure mercury lamp operated at various powers. The effective temperature could be calculated by considering the relative intensities of the two optically thin lines and comparison with the theoretical ratio of the temperature dependent power emitted from the lines derived from the atomic spectral data provided by NIST. The calculations gave effective arc temperatures of 5755, 5804 and 5820 K at 200, 225, 250 W respectively. This method was subsequently used as a basis for determining maximum effective arc temperature within microwave-driven electrodeless discharge capsules, with varying mercury content of 6.07, 9.4 and 12.95 mg within 1 × 10-6 m3 giving maximum effective temperatures of 5163, 4768 and 4715 K respectively at 240 W.

Possible combined influences of absorbing aerosols and anomalous atmospheric circulation on summertime diurnal temperature range variation over the middle and lower reaches of the Yangtze River

NASA Astrophysics Data System (ADS)

Cai, Jiaxi; Guan, Zhaoyong; Ma, Fenhua

2016-12-01

Based on the temperature data from the China Meteorological Administration, NCEP-NCAR reanalysis data, and the TOMS Aerosol Index (AI), we analyze the variations in the summertime diurnal temperature range (DTR) and temperature maxima in the middle and lower reaches of the Yangtze River (MLRYR) in China. The possible relationships between the direct warming effect of the absorbing aerosol and temperature variations are further investigated, although with some uncertainties. It is found that the summertime DTR exhibits a decreasing trend over the most recent 50 years, along with a slight increasing tendency since the 1980s. The trend of the maximum temperature is in agreement with those of the DTR and the absorbing aerosols. To investigate the causes of the large anomalies in the temperature maxima, composite analyses of the circulation anomalies are performed. When anomalous AI and anomalous maximum temperature over the MLRYR have the same sign, an anomalous circulation with a quasi-barotropic structure occurs there. This anomalous circulation is modulated by the Rossby wave energy propagations from the regions northwest of the MLRYR and influences the northwestern Pacific subtropical high over the MLRYR. In combination with aerosols, the anomalous circulation may increase the maximum temperature in this region. Conversely, when the anomalous AI and anomalous maximum temperature in the MLRYR have opposite signs, the anomalous circulation is not equivalently barotropic, which possibly offsets the warming effect of aerosols on the maximum temperature changes in this region. These results are helpful for a better understanding of the DTR changes and the occurrences of temperature extremes in the MLRYR region during boreal summer.

Optimization of the freeze-drying cycle: adaptation of the pressure rise analysis model to non-instantaneous isolation valves.

PubMed

Chouvenc, P; Vessot, S; Andrieu, J; Vacus, P

2005-01-01

The principal aim of this study is to extend to a pilot freeze-dryer equipped with a non-instantaneous isolation valve the previously presented pressure rise analysis (PRA) model for monitoring the product temperature and the resistance to mass transfer of the dried layer during primary drying. This method, derived from the original MTM method previously published, consists of interrupting rapidly (a few seconds) the water vapour flow from the sublimation chamber to the condenser and analysing the resulting dynamics of the total chamber pressure increase. The valve effect on the pressure rise profile observed during the isolation valve closing period was corrected by introducing in the initial PRA model a valve characteristic function factor which turned out to be independent of the operating conditions. This new extended PRA model was validated by implementing successively the two types of valves and by analysing the pressure rise kinetics data with the corresponding PRA models in the same operating conditions. The coherence and consistency shown on the identified parameter values (sublimation front temperature, dried layer mass transfer resistance) allowed validation of this extended PRA model with a non-instantaneous isolation valve. These results confirm that the PRA method, with or without an instantaneous isolation valve, is appropriate for on-line monitoring of product characteristics during freeze-drying. The advantages of PRA are that the method is rapid, non-invasive, and global. Consequently, PRA might become a powerful and promising tool not only for the control of pilot freeze-dryers but also for industrial freeze-dryers equipped with external condensers.

Temperature dependence of water diffusion pools in brain white matter.

PubMed

Dhital, Bibek; Labadie, Christian; Stallmach, Frank; Möller, Harald E; Turner, Robert

2016-02-15

Water diffusion in brain tissue can now be easily investigated using magnetic resonance (MR) techniques, providing unique insights into cellular level microstructure such as axonal orientation. The diffusive motion in white matter is known to be non-Gaussian, with increasing evidence for more than one water-containing tissue compartment. In this study, freshly excised porcine brain white matter was measured using a 125-MHz MR spectrometer (3T) equipped with gradient coils providing magnetic field gradients of up to 35,000 mT/m. The sample temperature was varied between -14 and +19 °C. The hypothesis tested was that white matter contains two slowly exchanging pools of water molecules with different diffusion properties. A Stejskal-Tanner diffusion sequence with very short gradient pulses and b-factors up to 18.8 ms/μm(2) was used. The dependence on b-factor of the attenuation due to diffusion was robustly fitted by a biexponential function, with comparable volume fractions for each component. The diffusion coefficient of each component follows Arrhenius behavior, with significantly different activation energies. The measured volume fractions are consistent with the existence of three water-containing compartments, the first comprising relatively free cytoplasmic and extracellular water molecules, the second of water molecules in glial processes, and the third comprising water molecules closely associated with membranes, as for example, in the myelin sheaths and elsewhere. The activation energy of the slow diffusion pool suggests proton hopping at the surface of membranes by a Grotthuss mechanism, mediated by hydrating water molecules. Copyright © 2015 Elsevier Inc. All rights reserved.

40 CFR 60.37e - Compliance, performance testing, and monitoring guidelines.

Code of Federal Regulations, 2010 CFR

2010-07-01

... requirements: (1) Establish maximum charge rate and minimum secondary chamber temperature as site-specific... above the maximum charge rate or below the minimum secondary chamber temperature measured as 3-hour... below the minimum secondary chamber temperature shall constitute a violation of the established...

MRI evidence of endolymphatic impermeability to the gadolinium molecule in the in vivo mouse inner ear at 9.4 tesla.

PubMed

Counter, S Allen; Nikkhou, Sahar; Brené, Stefan; Damberg, Peter; Sierakowiak, Adam; Klason, Tomas; Berglin, Cecilia Engmér; Laurell, Göran

2013-01-01

Previous in vivo experimental magnetic resonance imaging (MRI) investigations of the mammalian inner ear at 4.7 Tesla have indicated that intravenously injected gadolinium (Gd) penetrates the perilymphatic labyrinth, but not the endolymphatic membranous labyrinth. In the present study, high field MRI at 9.4T was used to visualize the in vivo mouse vestibulo-cochlea system, and to determine whether the endolymphatic system is permeable to a Gd complex. A 9.4 T Varian magnet equipped with a 12 cm inner diameter gradient system with maximum gradient strength of 600 mT/m, a millipede coil (Varian design) and a Gd contrast agent were used for image acquisition in the normal C57 BL-6 mouse. High-resolution 2D and 3D images of the mouse cochlea were acquired within 80 minutes following intravenous injection of Gd. Gd initially permeated the perilymphatic scala tympani and scala vestibuli, and permitted visualization of both cochlear turns from base to apex. The superior, inferior and lateral semicircular canals were subsequently visualized in 3 planes. The membranous endolymphatic labyrinth was impermeable to intravenously injected Gd, and thus showed no apparent uptake of Gd at 9.4T. The 9.4T field strength MRI permitted acquisition of high resolution images of anatomical and physiological features of the normal, wild type mouse perilymphatic inner ear in vivo, and provided further evidence that the endolymphatic system is impermeable to intravenously injected Gd.

A Miniaturized Antenna with Negative Index Metamaterial Based on Modified SRR and CLS Unit Cell for UWB Microwave Imaging Applications

PubMed Central

Islam, Md. Moinul; Islam, Mohammad Tariqul; Samsuzzaman, Md.; Faruque, Mohammad Rashed Iqbal; Misran, Norbahiah; Mansor, Mohd Fais

2015-01-01

A miniaturized antenna employing a negative index metamaterial with modified split-ring resonator (SRR) and capacitance-loaded strip (CLS) unit cells is presented for Ultra wideband (UWB) microwave imaging applications. Four left-handed (LH) metamaterial (MTM) unit cells are located along one axis of the antenna as the radiating element. Each left-handed metamaterial unit cell combines a modified split-ring resonator (SRR) with a capacitance-loaded strip (CLS) to obtain a design architecture that simultaneously exhibits both negative permittivity and negative permeability, which ensures a stable negative refractive index to improve the antenna performance for microwave imaging. The antenna structure, with dimension of 16 × 21 × 1.6 mm3, is printed on a low dielectric FR4 material with a slotted ground plane and a microstrip feed. The measured reflection coefficient demonstrates that this antenna attains 114.5% bandwidth covering the frequency band of 3.4–12.5 GHz for a voltage standing wave ratio of less than 2 with a maximum gain of 5.16 dBi at 10.15 GHz. There is a stable harmony between the simulated and measured results that indicate improved nearly omni-directional radiation characteristics within the operational frequency band. The stable surface current distribution, negative refractive index characteristic, considerable gain and radiation properties make this proposed negative index metamaterial antenna optimal for UWB microwave imaging applications. PMID:28787945

Scopolamine Administration Modulates Muscarinic, Nicotinic and NMDA Receptor Systems

PubMed Central

Höger, Harald; Pollak, Arnold; Lubec, Gert

2012-01-01

Studies on the effect of scopolamine on memory are abundant but so far only regulation of the muscarinic receptor (M1) has been reported. We hypothesized that levels of other cholinergic brain receptors as the nicotinic receptors and the N-methyl-D-aspartate (NMDA) receptor, known to be involved in memory formation, would be modified by scopolamine administration. C57BL/6J mice were used for the experiments and divided into four groups. Two groups were given scopolamine 1 mg/kg i.p. (the first group was trained and the second group untrained) in the multiple T-maze (MTM), a paradigm for evaluation of spatial memory. Likewise, vehicle-treated mice were trained or untrained thus serving as controls. Hippocampal levels of M1, nicotinic receptor alpha 4 (Nic4) and 7 (Nic7) and subunit NR1containing complexes were determined by immunoblotting on blue native gel electrophoresis. Vehicle-treated trained mice learned the task and showed memory retrieval on day 8, while scopolamine-treatment led to significant impairment of performance in the MTM. At the day of retrieval, hippocampal levels for M1, Nic7 and NR1 were higher in the scopolamine treated groups than in vehicle-treated groups. The concerted action, i.e. the pattern of four brain receptor complexes regulated by the anticholinergic compound scopolamine, is shown. Insight into probable action mechanisms of scopolamine at the brain receptor complex level in the hippocampus is provided. Scopolamine treatment is a standard approach to test cognitive enhancers and other psychoactive compounds in pharmacological studies and therefore knowledge on mechanisms is of pivotal interest. PMID:22384146

Q-Space Truncation and Sampling in Diffusion Spectrum Imaging

PubMed Central

Tian, Qiyuan; Rokem, Ariel; Folkerth, Rebecca D.; Nummenmaa, Aapo; Fan, Qiuyun; Edlow, Brian L.; McNab, Jennifer A.

2015-01-01

Purpose To characterize the q-space truncation and sampling on the spin-displacement probability density function (PDF) in diffusion spectrum imaging (DSI). Methods DSI data were acquired using the MGH-USC connectome scanner (Gmax=300mT/m) with bmax=30,000s/mm2, 17×17×17, 15×15×15 and 11×11×11 grids in ex vivo human brains and bmax=10,000s/mm2, 11×11×11 grid in vivo. An additional in vivo scan using bmax=7,000s/mm2, 11×11×11 grid was performed with a derated gradient strength of 40mT/m. PDFs and orientation distribution functions (ODFs) were reconstructed with different q-space filtering and PDF integration lengths, and from down-sampled data by factors of two and three. Results Both ex vivo and in vivo data showed Gibbs ringing in PDFs, which becomes the main source of artifact in the subsequently reconstructed ODFs. For down-sampled data, PDFs interfere with the first replicas or their ringing, leading to obscured orientations in ODFs. Conclusion The minimum required q-space sampling density corresponds to a field-of-view approximately equal to twice the mean displacement distance (MDD) of the tissue. The 11×11×11 grid is suitable for both ex vivo and in vivo DSI experiments. To minimize the effects of Gibbs ringing, ODFs should be reconstructed from unfiltered q-space data with the integration length over the PDF constrained to around the MDD. PMID:26762670

Achieving blood pressure control among renal transplant recipients by integrating electronic health technology and clinical pharmacy services.

PubMed

Migliozzi, Daniel R; Zullo, Andrew R; Collins, Christine; Elsaid, Khaled A

2015-11-15

The implementation and outcomes of a program combining electronic home blood pressure monitoring (HBPM) and pharmacist-provided medication therapy management (MTM) services in a renal transplantation clinic are described. Patients enrolled in the program were provided with a computer-enabled blood pressure monitor. A dedicated renal transplantation pharmacist was integrated into the renal transplantation team under a collaborative care practice agreement. The collaborative care agreement allowed the pharmacist to authorize medication additions, deletions, and dosage changes. Comprehensive disease and blood pressure education was provided by a clinical pharmacist. In the pretransplantation setting, the pharmacist interviewed the renal transplant candidate and documents allergies, verified the patient's medication profile, and identified and assessed barriers to medication adherence. A total of 50 renal transplant recipients with at least one recorded home blood pressure reading and at least one year of follow-up were included in our analysis. A significant reduction in mean systolic and diastolic blood pressure values were observed at 30, 90, 180, and 360 days after enrollment in the program (p < 0.05). Pharmacist interventions were documented for 37 patients. Medication-related problems accounted for 46% of these interventions and included dosage modifications, regimen changes, and mitigation of barriers to medication access and adherence. Implementation of electronic HBPM and pharmacist-provided MTM services implemented in a renal transplant clinic was associated with sustained improvements in blood pressure control. Incorporation of a pharmacist in the renal transplant clinic resulted in the detection and resolution of medication-related problems. Copyright © 2015 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

A patient-centered pharmacy services model of HIV patient care in community pharmacy settings: a theoretical and empirical framework.

PubMed

Kibicho, Jennifer; Owczarzak, Jill

2012-01-01

Reflecting trends in health care delivery, pharmacy practice has shifted from a drug-specific to a patient-centered model of care, aimed at improving the quality of patient care and reducing health care costs. In this article, we outline a theoretical model of patient-centered pharmacy services (PCPS), based on in-depth, qualitative interviews with a purposive sample of 28 pharmacists providing care to HIV-infected patients in specialty, semispecialty, and nonspecialty pharmacy settings. Data analysis was an interactive process informed by pharmacists' interviews and a review of the general literature on patient centered care, including Medication Therapy Management (MTM) services. Our main finding was that the current models of pharmacy services, including MTM, do not capture the range of pharmacy services in excess of mandated drug dispensing services. In this article, we propose a theoretical PCPS model that reflects the actual services pharmacists provide. The model includes five elements: (1) addressing patients as whole, contextualized persons; (2) customizing interventions to unique patient circumstances; (3) empowering patients to take responsibility for their own health care; (4) collaborating with clinical and nonclinical providers to address patient needs; and (5) developing sustained relationships with patients. The overarching goal of PCPS is to empower patients' to take responsibility for their own health care and self-manage their HIV-infection. Our findings provide the foundation for future studies regarding how widespread these practices are in diverse community settings, the validity of the proposed PCPS model, the potential for standardizing pharmacist practices, and the feasibility of a PCPS framework to reimburse pharmacists services.

Auscultation in flight: comparison of conventional and electronic stethoscopes.

PubMed

Tourtier, J P; Libert, N; Clapson, P; Tazarourte, K; Borne, M; Grasser, L; Debien, B; Auroy, Y

2011-01-01

The ability to auscultate during air medical transport is compromised by high ambient-noise levels. The aim of this study was to assess the capabilities of a traditional and an electronic stethoscope (which is expected to amplify sounds and reduce ambient noise) to assess heart and breath sounds during medical transport in a Boeing C135. We tested one model of a traditional stethoscope (3MTM Littmann Cardiology IIITM) and one model of an electronic stethoscope (3MTM Littmann Stethoscope Model 3000). We studied heart and lung auscultation during real medical evacuations aboard a medically configured C135. For each device, the quality of auscultation was described using a visual rating scale (ranging from 0 to 100 mm, 0 corresponding to "I hear nothing," 100 to "I hear perfectly"). Comparisons were accomplished using a t-test for paired values. A total of 36 comparative evaluations were performed. For cardiac auscultation, the value of the visual rating scale was 53 ± 24 and 85 ± 11 mm, respectively, for the traditional and electronic stethoscope (paired t-test: P = .0024). For lung sounds, quality of auscultation was estimated at 27 ± 17 mm for traditional stethoscope and 68 ± 13 for electronic stethoscope (paired t-test: P = .0003). The electronic stethoscope was considered to be better than the standard model for hearing heart and lung sounds. Flight practitioners involved in air medical evacuation in the C135 aircraft are better able to practice auscultation with this electronic stethoscope than with a traditional one. Copyright © 2011 Air Medical Journal Associates. Published by Elsevier Inc. All rights reserved.

Learning at different satiation levels reveals parallel functions for the cAMP-protein kinase A cascade in formation of long-term memory.

PubMed

Friedrich, Anke; Thomas, Ulf; Müller, Uli

2004-05-05

Learning and memory formation in intact animals is generally studied under defined parameters, including the control of feeding. We used associative olfactory conditioning of the proboscis extension response in honeybees to address effects of feeding status on processes of learning and memory formation. Comparing groups of animals with different but defined feeding status at the time of conditioning reveals new and characteristic features in memory formation. In animals fed 18 hr earlier, three-trial conditioning induces a stable memory that consists of different phases: a mid-term memory (MTM), translation-dependent early long-term memory (eLTM; 1-2 d), and a transcription-dependent late LTM (lLTM; > or =3 d). Additional feeding of a small amount of sucrose 4 hr before conditioning leads to a loss of all of these memory phases. Interestingly, the basal activity of the cAMP-dependent protein kinase A (PKA), a key player in LTM formation, differs in animals with different satiation levels. Pharmacological rescue of the low basal PKA activity in animals fed 4 hr before conditioning points to a specific function of cAMP-PKA cascade in mediating satiation-dependent memory formation. An increase in PKA activity during conditioning rescues only transcription-dependent lLTM; acquisition, MTM, and eLTM are still impaired. Thus, during conditioning, the cAMP-PKA cascade mediates the induction of the transcription-dependent lLTM, depending on the satiation level. This result provides the first evidence for a central and distinct function of the cAMP-PKA cascade connecting satiation level with learning.

Analytical performance bounds for multi-tensor diffusion-MRI.

PubMed

Ahmed Sid, Farid; Abed-Meraim, Karim; Harba, Rachid; Oulebsir-Boumghar, Fatima

2017-02-01

To examine the effects of MR acquisition parameters on brain white matter fiber orientation estimation and parameter of clinical interest in crossing fiber areas based on the Multi-Tensor Model (MTM). We compute the Cramér-Rao Bound (CRB) for the MTM and the parameter of clinical interest such as the Fractional Anisotropy (FA) and the dominant fiber orientations, assuming that the diffusion MRI data are recorded by a multi-coil, multi-shell acquisition system. Considering the sum-of-squares method for the reconstructed magnitude image, we introduce an approximate closed-form formula for Fisher Information Matrix that has the simplicity and easy interpretation advantages. In addition, we propose to generalize the FA and the mean diffusivity to the multi-tensor model. We show the application of the CRB to reduce the scan time while preserving a good estimation precision. We provide results showing how the increase of the number of acquisition coils compensates the decrease of the number of diffusion gradient directions. We analyze the impact of the b-value and the Signal-to-Noise Ratio (SNR). The analysis shows that the estimation error variance decreases with a quadratic rate with the SNR, and that the optimum b-values are not unique but depend on the target parameter, the context, and eventually the target cost function. In this study we highlight the importance of choosing the appropriate acquisition parameters especially when dealing with crossing fiber areas. We also provide a methodology for the optimal tuning of these parameters using the CRB. Copyright © 2016 Elsevier Inc. All rights reserved.

Sp1 is a transcription repressor to stanniocalcin-1 expression in TSA-treated human colon cancer cells, HT29.

PubMed

Law, Alice Y S; Yeung, B H Y; Ching, L Y; Wong, Chris K C

2011-08-01

Our previous study demonstrated that, stanniocalcin-1 (STC1) was a target of histone deacetylase (HDAC) inhibitors and was involved in trichostatin A (TSA) induced apoptosis in the human colon cancer cells, HT29. In this study, we reported that the transcriptional factor, specificity protein 1 (Sp1) in association with retinoblastoma (Rb) repressed STC1 gene transcription in TSA-treated HT29 cells. Our data demonstrated that, a co-treatment of the cells with TSA and Sp1 inhibitor, mithramycin A (MTM) led to a marked synergistic induction of STC1 transcript levels, STC1 promoter (1 kb)-driven luciferase activity and an increase of apoptotic cell population. The knockdown of Sp1 gene expression in TSA treated cells, revealed the repressor role of Sp1 in STC1 transcription. Using a protein phosphatase inhibitor okadaic acid (OKA), an increase of Sp1 hyperphosphorylation and so a reduction of its transcriptional activity, led to a significant induction of STC1 gene expression. Chromatin immunoprecipitation (ChIP) assay revealed that Sp1 binding on STC1 proximal promoter in TSA treated cells. The binding of Sp1 to STC1 promoter was abolished by the co-treatment of MTM or OKA in TSA-treated cells. Re-ChIP assay illustrated that Sp1-mediated inhibition of STC1 transcription was associated with the recruitment of another repressor molecule, Rb. Collectively our findings identify STC1 is a downstream target of Sp1. Copyright © 2011 Wiley-Liss, Inc.

Comparative efficacy, acceptability, and safety of medicinal, cognitive-behavioral therapy, and placebo treatments for acute major depressive disorder in children and adolescents: a multiple-treatments meta-analysis.

PubMed

Ma, Dongfeng; Zhang, Zhijun; Zhang, Xiangrong; Li, Lingjiang

2014-06-01

New generation antidepressant therapies, including serotonin-norepinephrine reuptake inhibitor (SNRIs) and selective serotonin reuptake inhibitors (SSRIs) were introduced in the late 1980s; however, few comprehensive studies compared the benefits and risks of various contemporary treatments for major depressive disorder (MDD) in pediatric patients. Multiple-treatments meta-analysis (MTM) was conducted to assess efficacy, acceptability, and safety of contemporary interventions in children and adolescents with MDD. Cochrane Library, AMED, CINAHL, EMBASE, LiLACS, MEDLINE, PSYCINFO, PSYNDEX, and Journal of Medicine and Pharmacy databases were searched for randomized controlled trials (RCTs) comparing medicinal interventions (citalopram, escitalopram, fluoxetine, mirtazapine, paroxetine, sertraline, venlafaxine), cognitive behavioral therapy (CBT), combined fluoxetine with CBT, and placebo treatment for acute MDD from January 1988 to March 2013. Treatment success, dropout rate, and suicidal ideation/attempt outcomes were measured. Bayesian methods were used to conduct a MTM including age and funding subgroups. A total of 21 RCTs (4969 participants) were identified. Combined fluoxetine/CBT exhibited the highest efficacy, with fluoxetine alone superior to CBT, paroxetine, sertraline, citalopram, escitalopram, and placebo treatment. Sertraline, paroxetine, escitalopram, and venlafaxine showed superior acceptability to fluoxetine and combined fluoxetine/CBT. Combined fluoxetine/CBT combination was less safe, though CBT was safer than fluoxetine alone. Combined fluoxetine/CBT, fluoxetine, and mirtazapine exhibited the highest efficacy; sertraline, escitalopram, venlafaxine, and paroxetine were the best tolerated; and mirtazapine and venlafaxine were the safest. Sertraline and mirtazapine exhibited optimally balanced efficacy, acceptability, and safety for first-line acute treatment of child and adolescent MDD.

Preliminary analysis of hot spot factors in an advanced reactor for space electric power systems

NASA Technical Reports Server (NTRS)

Lustig, P. H.; Holms, A. G.; Davison, H. W.

1973-01-01

The maximum fuel pin temperature for nominal operation in an advanced power reactor is 1370 K. Because of possible nitrogen embrittlement of the clad, the fuel temperature was limited to 1622 K. Assuming simultaneous occurrence of the most adverse conditions a deterministic analysis gave a maximum fuel temperature of 1610 K. A statistical analysis, using a synthesized estimate of the standard deviation for the highest fuel pin temperature, showed probabilities of 0.015 of that pin exceeding the temperature limit by the distribution free Chebyshev inequality and virtually nil assuming a normal distribution. The latter assumption gives a 1463 K maximum temperature at 3 standard deviations, the usually assumed cutoff. Further, the distribution and standard deviation of the fuel-clad gap are the most significant contributions to the uncertainty in the fuel temperature.

System for Repairing Cracks in Structures

NASA Technical Reports Server (NTRS)

Smith, Stephen W. (Inventor); Newman, John A. (Inventor); Piascik, Robert S. (Inventor); Glaessgen, Edward H. (Inventor)

2014-01-01

A first material with a known maximum temperature of operation is coated with a second material on at least one surface of the first material. The coating has a melting temperature that is greater than the maximum temperature of operation of the first material. The coating is heated to its melting temperature until the coating flows into any cracks in the first material's surface.

Thermal management improvement of an air-cooled high-power lithium-ion battery by embedding metal foam

NASA Astrophysics Data System (ADS)

Mohammadian, Shahabeddin K.; Rassoulinejad-Mousavi, Seyed Moein; Zhang, Yuwen

2015-11-01

Effect of embedding aluminum porous metal foam inside the flow channels of an air-cooled Li-ion battery module was studied to improve its thermal management. Four different cases of metal foam insert were examined using three-dimensional transient numerical simulations. The effects of permeability and porosity of the porous medium as well as state of charge were investigated on the standard deviation of the temperature field and maximum temperature inside the battery in all four cases. Compared to the case of no porous insert, embedding aluminum metal foam in the air flow channel significantly improved the thermal management of Li-ion battery cell. The results also indicated that, decreasing the porosity of the porous structure decreases both standard deviation of the temperature field and maximum temperature inside the battery. Moreover, increasing the permeability of the metal foam drops the maximum temperature inside the battery while decreasing this property leads to improving the temperature uniformity. Our results suggested that, among the all studied cases, desirable temperature uniformity and maximum temperature were achieved when two-third and the entire air flow channel is filled with aluminum metal foam, respectively.

Temperature Observation Time and Type Influence Estimates of Heat-Related Mortality in Seven U.S. Cities.

PubMed

Davis, Robert E; Hondula, David M; Patel, Anjali P

2016-06-01

Extreme heat is a leading weather-related cause of mortality in the United States, but little guidance is available regarding how temperature variable selection impacts heat-mortality relationships. We examined how the strength of the relationship between daily heat-related mortality and temperature varies as a function of temperature observation time, lag, and calculation method. Long time series of daily mortality counts and hourly temperature for seven U.S. cities with different climates were examined using a generalized additive model. The temperature effect was modeled separately for each hour of the day (with up to 3-day lags) along with different methods of calculating daily maximum, minimum, and mean temperature. We estimated the temperature effect on mortality for each variable by comparing the 99th versus 85th temperature percentiles, as determined from the annual time series. In three northern cities (Boston, MA; Philadelphia, PA; and Seattle, WA) that appeared to have the greatest sensitivity to heat, hourly estimates were consistent with a diurnal pattern in the heat-mortality response, with strongest associations for afternoon or maximum temperature at lag 0 (day of death) or afternoon and evening of lag 1 (day before death). In warmer, southern cities, stronger associations were found with morning temperatures, but overall the relationships were weaker. The strongest temperature-mortality relationships were associated with maximum temperature, although mean temperature results were comparable. There were systematic and substantial differences in the association between temperature and mortality based on the time and type of temperature observation. Because the strongest hourly temperature-mortality relationships were not always found at times typically associated with daily maximum temperatures, temperature variables should be selected independently for each study location. In general, heat-mortality was more closely coupled to afternoon and maximum temperatures in most cities we examined, particularly those typically prone to heat-related mortality. Davis RE, Hondula DM, Patel AP. 2016. Temperature observation time and type influence estimates of heat-related mortality in seven U.S. cities. Environ Health Perspect 124:795-804; http://dx.doi.org/10.1289/ehp.1509946.

Measuring non-condensable gases in steam.

PubMed

van Doornmalen, J P C M; Kopinga, K

2013-11-01

In surgery, medical devices that are used should be sterilized. To obtain surface steam sterilization conditions, not only in the sterilizer chamber itself but also in the loads to be sterilized, the amount of non-condensable gases (NCGs), for instance air, should be very low. Even rather small fractions of NCGs (below 1%) seriously hamper steam penetration in porous materials or devices with hollow channels (e.g., endoscopes). A recently developed instrument which might detect the presence of residual NCGs in a reliable and reproducible way is the 3M(TM) Electronic Test System (ETS). In this paper, a physical model is presented that describes the behavior of this instrument. This model has been validated by experiments in which known fractions of NCGs were introduced in a sterilizer chamber in which an ETS was placed. Despite several approximations made in the model, a good agreement is found between the model predictions and the experimental results. The basic principle of the ETS, measuring the heat transfer by condensation on a cooled surface, permits a very sensitive detection of NCGs in harsh environments like water vapor at high temperatures and pressures. Our model may serve to develop adapted and optimized versions of this instrument for use outside the field of sterilization, e.g., in heat exchangers based on steam condensation.

Measuring non-condensable gases in steam

NASA Astrophysics Data System (ADS)

van Doornmalen, J. P. C. M.; Kopinga, K.

2013-11-01

In surgery, medical devices that are used should be sterilized. To obtain surface steam sterilization conditions, not only in the sterilizer chamber itself but also in the loads to be sterilized, the amount of non-condensable gases (NCGs), for instance air, should be very low. Even rather small fractions of NCGs (below 1 %) seriously hamper steam penetration in porous materials or devices with hollow channels (e.g., endoscopes). A recently developed instrument which might detect the presence of residual NCGs in a reliable and reproducible way is the 3MTM Electronic Test System (ETS). In this paper, a physical model is presented that describes the behavior of this instrument. This model has been validated by experiments in which known fractions of NCGs were introduced in a sterilizer chamber in which an ETS was placed. Despite several approximations made in the model, a good agreement is found between the model predictions and the experimental results. The basic principle of the ETS, measuring the heat transfer by condensation on a cooled surface, permits a very sensitive detection of NCGs in harsh environments like water vapor at high temperatures and pressures. Our model may serve to develop adapted and optimized versions of this instrument for use outside the field of sterilization, e.g., in heat exchangers based on steam condensation.

40 CFR Table 4 to Subpart Ooo of... - Operating Parameter Levels

Code of Federal Regulations, 2011 CFR

2011-07-01

... specific gravity Condenser Exit temperature Maximum temperature Carbon absorber Total regeneration steam or nitrogen flow, or pressure (gauge or absolute) a during carbon bed regeneration cycle; and temperature of the carbon bed after regeneration (and within 15 minutes of completing any cooling cycle(s)) Maximum...

40 CFR Table 4 to Subpart Ooo of... - Operating Parameter Levels

Code of Federal Regulations, 2013 CFR

2013-07-01

... specific gravity Condenser Exit temperature Maximum temperature Carbon absorber Total regeneration steam or nitrogen flow, or pressure (gauge or absolute) a during carbon bed regeneration cycle; and temperature of the carbon bed after regeneration (and within 15 minutes of completing any cooling cycle(s)) Maximum...

40 CFR Table 4 to Subpart Ooo of... - Operating Parameter Levels

Code of Federal Regulations, 2014 CFR

2014-07-01

... specific gravity Condenser Exit temperature Maximum temperature Carbon absorber Total regeneration steam or nitrogen flow, or pressure (gauge or absolute) a during carbon bed regeneration cycle; and temperature of the carbon bed after regeneration (and within 15 minutes of completing any cooling cycle(s)) Maximum...

Fishing and bottom water temperature as drivers of change in maximum shell length in Atlantic surfclams (Spisula solidissima)

NASA Astrophysics Data System (ADS)

Munroe, D. M.; Narváez, D. A.; Hennen, D.; Jacobson, L.; Mann, R.; Hofmann, E. E.; Powell, E. N.; Klinck, J. M.

2016-03-01

Maximum shell length of Atlantic surfclams (Spisula solidissima) on the Middle Atlantic Bight (MAB) continental shelf, obtained from federal fishery survey data from 1982-present, has decreased by 15-20 mm. Two potential causes of this decreasing trend, fishery removal of large animals and stress due to warming bottom temperatures, were investigated using an individual-based model for post-settlement surfclams and a fifty-year hindcast of bottom water temperatures on the MAB. Simulations showed that fishing and/or warming bottom water temperature can cause decreases in maximum surfclam shell length (body size) equivalent to those observed in the fished stock. Independently, either localized fishing rates of 20% or sustained bottom temperatures that are 2 °C warmer than average conditions generate the observed decrease in maximum shell length. However, these independent conditions represent extremes and are not sustained in the MAB. The combined effects of fishing and warmer temperatures can generate simulated length decreases that are similar to observed decreases. Interannual variability in bottom water temperatures can also generate fluctuations in simulated shell length of up to 20 mm over a period of 10-15 years. If the change in maximum size is not genotypic, simulations also suggest that shell size composition of surfclam populations can recover if conditions change; however, that recovery could take a decade to become evident.

Temperature Observation Time and Type Influence Estimates of Heat-Related Mortality in Seven U.S. Cities

PubMed Central

Davis, Robert E.; Hondula, David M.; Patel, Anjali P.

2015-01-01

Background: Extreme heat is a leading weather-related cause of mortality in the United States, but little guidance is available regarding how temperature variable selection impacts heat–mortality relationships. Objectives: We examined how the strength of the relationship between daily heat-related mortality and temperature varies as a function of temperature observation time, lag, and calculation method. Methods: Long time series of daily mortality counts and hourly temperature for seven U.S. cities with different climates were examined using a generalized additive model. The temperature effect was modeled separately for each hour of the day (with up to 3-day lags) along with different methods of calculating daily maximum, minimum, and mean temperature. We estimated the temperature effect on mortality for each variable by comparing the 99th versus 85th temperature percentiles, as determined from the annual time series. Results: In three northern cities (Boston, MA; Philadelphia, PA; and Seattle, WA) that appeared to have the greatest sensitivity to heat, hourly estimates were consistent with a diurnal pattern in the heat-mortality response, with strongest associations for afternoon or maximum temperature at lag 0 (day of death) or afternoon and evening of lag 1 (day before death). In warmer, southern cities, stronger associations were found with morning temperatures, but overall the relationships were weaker. The strongest temperature–mortality relationships were associated with maximum temperature, although mean temperature results were comparable. Conclusions: There were systematic and substantial differences in the association between temperature and mortality based on the time and type of temperature observation. Because the strongest hourly temperature–mortality relationships were not always found at times typically associated with daily maximum temperatures, temperature variables should be selected independently for each study location. In general, heat-mortality was more closely coupled to afternoon and maximum temperatures in most cities we examined, particularly those typically prone to heat-related mortality. Citation: Davis RE, Hondula DM, Patel AP. 2016. Temperature observation time and type influence estimates of heat-related mortality in seven U.S. cities. Environ Health Perspect 124:795–804; http://dx.doi.org/10.1289/ehp.1509946 PMID:26636734

A New Method to Measure Temperature and Burner Pattern Factor Sensing for Active Engine Control

NASA Technical Reports Server (NTRS)

Ng, Daniel

1999-01-01

The determination of the temperatures of extended surfaces which exhibit non-uniform temperature variation is very important for a number of applications including the "Burner Pattern Factor" (BPF) of turbine engines. Exploratory work has shown that use of BPF to control engine functions can result in many benefits, among them reduction in engine weight, reduction in operating cost, increase in engine life, while attaining maximum engine efficiency. Advanced engines are expected to operate at very high temperature to achieve high efficiency. Brief exposure of engine components to higher than design temperatures due to non-uniformity in engine burner pattern can reduce engine life. The engine BPF is a measure of engine temperature uniformity. Attainment of maximum temperature uniformity and high temperatures is key to maximum efficiency and long life. A new approach to determine through the measurement of just one radiation spectrum by a multiwavelength pyrometer is possible. This paper discusses a new temperature sensing approach and its application to determine the BPF.

May–June Maximum Temperature Reconstruction from Mean Earlywood Density in North Central China and Its Linkages to the Summer Monsoon Activities

PubMed Central

Chen, Feng; Yuan, Yujiang

2014-01-01

Cores of Pinus tabulaformis from Tianshui were subjected to densitometric analysis to obtain mean earlywood density data. Climate response analysis indicates that May–June maximum temperature is the main factor limiting the mean earlywood density (EWD) of Chinese pine trees in the Shimen Mountains. Based on the EWD chronology, we have reconstructed May–June maximum temperature 1666 to 2008 for Tianshui, north central China. The reconstruction explains 40.1% of the actual temperature variance during the common period 1953–2008. The temperature reconstruction is representative of temperature conditions over a large area to the southeast and northwest of the sampling site. Preliminary analysis of links between large-scale climatic variation and the temperature reconstruction shows that there is a relationship between extremes in spring temperature and anomalous atmospheric circulation in the region. It is thus revealed that the mean earlywood density chronology of Pinus tabulaformis has enough potential to reconstruct the temperature variability further into the past. PMID:25207554

Estimating Long-Term Survival Temperatures at the Assemblage Level in the Marine Environment: Towards Macrophysiology

PubMed Central

Richard, Joëlle; Morley, Simon Anthony; Thorne, Michael A. S.; Peck, Lloyd Samuel

2012-01-01

Defining ecologically relevant upper temperature limits of species is important in the context of environmental change. The approach used in the present paper estimates the relationship between rates of temperature change and upper temperature limits for survival in order to evaluate the maximum long-term survival temperature (Ts). This new approach integrates both the exposure time and the exposure temperature in the evaluation of temperature limits. Using data previously published for different temperate and Antarctic marine environments, we calculated Ts in each environment, which allowed us to calculate a new index: the Warming Allowance (WA). This index is defined as the maximum environmental temperature increase which an ectotherm in a given environment can tolerate, possibly with a decrease in performance but without endangering survival over seasonal or lifetime time-scales. It is calculated as the difference between maximum long-term survival temperature (Ts) and mean maximum habitat temperature. It provides a measure of how close a species, assemblage or fauna are living to their temperature limits for long-term survival and hence their vulnerability to environmental warming. In contrast to data for terrestrial environments showing that warming tolerance increases with latitude, results here for marine environments show a less clear pattern as the smallest WA value was for the Peru upwelling system. The method applied here, relating upper temperature limits to rate of experimental warming, has potential for wide application in the identification of faunas with little capacity to survive environmental warming. PMID:22509340

Metamaterial Designs for Photovoltaic and IR Focal-Plane-Imaging Array Applications

DTIC Science & Technology

2013-03-01

incident angles above 17 degrees. There also seems to be no Brewster angle (i.e. the angle at which reflection = 0) for the reflection from the MTM...half- space, while glass has as Brewster angle at 56 degrees incident for TM polarized light. 0 5 10 15 20 25 30 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9...and incident spot beams from an objective lens . The spot beams hitting the detectors are absorbed, but the power of the spot beams falling in between

ENSO related variability in the Southern Hemisphere, 1948-2000

NASA Astrophysics Data System (ADS)

Ribera, Pedro; Mann, Michael E.

2003-01-01

The spatiotemporal evolution of Southern Hemisphere climate variability is diagnosed based on the use of the NCEP reanalysis (1948-2000) dataset. Using the MTM-SVD analysis method, significant narrowband variability is isolated from the multi-variate dataset. It is found that the ENSO signal exhibits statistically significant behavior at quasiquadrennial (3-6 yr) timescales for the full time-period. A significant quasibiennial (2-3 yr) timescales emerges only for the latter half of period. Analyses of the spatial evolution of the two reconstructed signals shed additional light on linkages between low and high-latitude Southern Hemisphere climate anomalies.

Topographic map of the western region of Dao Vallis in Hellas Planitia, Mars; MTM 500k -40/082E OMKT

USGS Publications Warehouse

Rosiek, Mark R.; Redding, Bonnie L.; Galuszka, Donna M.

2006-01-01

This map, compiled photogrammetrically from Viking Orbiter stereo image pairs, is part of a series of topographic maps of areas of special scientific interest on Mars. Contours were derived from a digital terrain model (DTM) compiled on a digital photogrammetric workstation using Viking Orbiter stereo image pairs with orientation parameters derived from an analytic aerotriangulation. The image base for this map employs Viking Orbiter images from orbits 406 and 363. An orthophotomosaic was created on the digital photogrammetric workstation using the DTM compiled from stereo models.

Predicting tropical cyclone intensity using satellite measured equivalent blackbody temperatures of cloud tops. [regression analysis

NASA Technical Reports Server (NTRS)

Gentry, R. C.; Rodgers, E.; Steranka, J.; Shenk, W. E.

1978-01-01

A regression technique was developed to forecast 24 hour changes of the maximum winds for weak (maximum winds less than or equal to 65 Kt) and strong (maximum winds greater than 65 Kt) tropical cyclones by utilizing satellite measured equivalent blackbody temperatures around the storm alone and together with the changes in maximum winds during the preceding 24 hours and the current maximum winds. Independent testing of these regression equations shows that the mean errors made by the equations are lower than the errors in forecasts made by the peristence techniques.

Variability of Diurnal Temperature Range During Winter Over Western Himalaya: Range- and Altitude-Wise Study

NASA Astrophysics Data System (ADS)

Shekhar, M. S.; Devi, Usha; Dash, S. K.; Singh, G. P.; Singh, Amreek

2018-04-01

The current trends in diurnal temperature range, maximum temperature, minimum temperature, mean temperature, and sun shine hours over different ranges and altitudes of Western Himalaya during winter have been studied. Analysis of 25 years of data shows an increasing trend in diurnal temperature range over all the ranges and altitudes of Western Himalaya during winter, thereby confirming regional warming of the region due to present climate change and global warming. Statistical studies show significant increasing trend in maximum temperature over all the ranges and altitudes of Western Himalaya. Minimum temperature shows significant decreasing trend over Pir Panjal and Shamshawari range and significant increasing trend over higher altitude of Western Himalaya. Similarly, sunshine hours show significant decreasing trend over Karakoram range. There exists strong positive correlation between diurnal temperature range and maximum temperature for all the ranges and altitudes of Western Himalaya. Strong negative correlation exists between diurnal temperature range and minimum temperature over Shamshawari and Great Himalaya range and lower altitude of Western Himalaya. Sunshine hours show strong positive correlation with diurnal temperature range over Pir Panjal and Great Himalaya range and lower and higher altitudes.

40 CFR Table 7 to Subpart U of... - Operating Parameters for Which Monitoring Levels Are Required To Be Established for Continuous...

Code of Federal Regulations, 2012 CFR

2012-07-01

.... Condenser Exit temperature Maximum temperature. Carbon adsorber Total regeneration steam flow or nitrogen flow, or pressure (gauge or absolute) a during carbon bed regeneration cycle; and temperature of the carbon bed after regeneration (and within 15 minutes of completing any cooling cycle(s)) Maximum flow or...

40 CFR Table 7 to Subpart Ppp of... - Process Vents From Continuous Unit Operations-Monitoring, Recordkeeping, and Reporting Requirements

Code of Federal Regulations, 2010 CFR

2010-07-01

... absorbent is used. Condenser Exit temperature Maximum temperature. Carbon adsorber Total regeneration stream mass or volumetric flow during carbon bed regeneration cycle; and temperature of the carbon bed after regeneration (and within 15 minutes of completing any cooling cycle(s)) Maximum mass or volumetric flow; and...

40 CFR Table 7 to Subpart U of... - Operating Parameters for Which Monitoring Levels Are Required To Be Established for Continuous...

Code of Federal Regulations, 2014 CFR

2014-07-01

.... Condenser Exit temperature Maximum temperature. Carbon adsorber Total regeneration steam flow or nitrogen flow, or pressure (gauge or absolute) a during carbon bed regeneration cycle; and temperature of the carbon bed after regeneration (and within 15 minutes of completing any cooling cycle(s)) Maximum flow or...

40 CFR Table 7 to Subpart Ppp of... - Process Vents From Continuous Unit Operations-Monitoring, Recordkeeping, and Reporting Requirements

Code of Federal Regulations, 2012 CFR

2012-07-01

... absorbent is used. Condenser Exit temperature Maximum temperature. Carbon adsorber Total regeneration stream mass or volumetric flow during carbon bed regeneration cycle; and temperature of the carbon bed after regeneration (and within 15 minutes of completing any cooling cycle(s)) Maximum mass or volumetric flow; and...

40 CFR Table 7 to Subpart Ppp of... - Process Vents From Continuous Unit Operations-Monitoring, Recordkeeping, and Reporting Requirements

Code of Federal Regulations, 2011 CFR

2011-07-01

... absorbent is used. Condenser Exit temperature Maximum temperature. Carbon adsorber Total regeneration stream mass or volumetric flow during carbon bed regeneration cycle; and temperature of the carbon bed after regeneration (and within 15 minutes of completing any cooling cycle(s)) Maximum mass or volumetric flow; and...

40 CFR Table 7 to Subpart U of... - Operating Parameters for Which Monitoring Levels Are Required To Be Established for Continuous...

Code of Federal Regulations, 2010 CFR

2010-07-01

.... Condenser Exit temperature Maximum temperature. Carbon adsorber Total regeneration steam flow or nitrogen flow, or pressure (gauge or absolute) a during carbon bed regeneration cycle; and temperature of the carbon bed after regeneration (and within 15 minutes of completing any cooling cycle(s)) Maximum flow or...

40 CFR Table 7 to Subpart U of... - Operating Parameters for Which Monitoring Levels Are Required To Be Established for Continuous...

Code of Federal Regulations, 2011 CFR

2011-07-01

.... Condenser Exit temperature Maximum temperature. Carbon adsorber Total regeneration steam flow or nitrogen flow, or pressure (gauge or absolute) a during carbon bed regeneration cycle; and temperature of the carbon bed after regeneration (and within 15 minutes of completing any cooling cycle(s)) Maximum flow or...

40 CFR Table 7 to Subpart U of... - Operating Parameters for Which Monitoring Levels Are Required To Be Established for Continuous...

Code of Federal Regulations, 2013 CFR

2013-07-01

.... Condenser Exit temperature Maximum temperature. Carbon adsorber Total regeneration steam flow or nitrogen flow, or pressure (gauge or absolute) a during carbon bed regeneration cycle; and temperature of the carbon bed after regeneration (and within 15 minutes of completing any cooling cycle(s)) Maximum flow or...

40 CFR 86.133-96 - Diurnal emission test.

Code of Federal Regulations, 2011 CFR

2011-07-01

... according to the profile specified in § 86.133 and appendix II of this part. (1) Temperatures measured with the underbody temperature sensor shall follow the profile with a maximum deviation of 3 °F at any time... temperature sensors shall follow the profile with a maximum deviation of 5 °F at any time. (2) Ambient...

40 CFR 86.1233-96 - Diurnal emission test.

Code of Federal Regulations, 2011 CFR

2011-07-01

... according to the profile specified in § 86.1233 and appendix II of this part. (1) Temperatures measured with the underbody temperature sensor shall follow the profile with a maximum deviation of 3 °F at any time... temperature sensors shall follow the profile with a maximum deviation of 5 °F at any time. (2) Ambient...

40 CFR 86.133-96 - Diurnal emission test.

Code of Federal Regulations, 2013 CFR

2013-07-01

... according to the profile specified in § 86.133 and appendix II of this part. (1) Temperatures measured with the underbody temperature sensor shall follow the profile with a maximum deviation of 3 °F at any time... temperature sensors shall follow the profile with a maximum deviation of 5 °F at any time. (2) Ambient...

40 CFR 86.1233-96 - Diurnal emission test.

Code of Federal Regulations, 2013 CFR

2013-07-01

... according to the profile specified in § 86.1233 and appendix II of this part. (1) Temperatures measured with the underbody temperature sensor shall follow the profile with a maximum deviation of 3 °F at any time... temperature sensors shall follow the profile with a maximum deviation of 5 °F at any time. (2) Ambient...

40 CFR 86.133-96 - Diurnal emission test.

Code of Federal Regulations, 2014 CFR

2014-07-01

... according to the profile specified in § 86.133 and appendix II of this part. (1) Temperatures measured with the underbody temperature sensor shall follow the profile with a maximum deviation of 3 °F at any time... temperature sensors shall follow the profile with a maximum deviation of 5 °F at any time. (2) Ambient...

40 CFR 86.1233-96 - Diurnal emission test.

Code of Federal Regulations, 2012 CFR

2012-07-01

... according to the profile specified in § 86.1233 and appendix II of this part. (1) Temperatures measured with the underbody temperature sensor shall follow the profile with a maximum deviation of 3 °F at any time... temperature sensors shall follow the profile with a maximum deviation of 5 °F at any time. (2) Ambient...

40 CFR 86.133-96 - Diurnal emission test.

Code of Federal Regulations, 2012 CFR

2012-07-01

... according to the profile specified in § 86.133 and appendix II of this part. (1) Temperatures measured with the underbody temperature sensor shall follow the profile with a maximum deviation of 3 °F at any time... temperature sensors shall follow the profile with a maximum deviation of 5 °F at any time. (2) Ambient...

Analysis and modeling of extreme temperatures in several cities in northwestern Mexico under climate change conditions

NASA Astrophysics Data System (ADS)

García-Cueto, O. Rafael; Cavazos, M. Tereza; de Grau, Pamela; Santillán-Soto, Néstor

2014-04-01

The generalized extreme value distribution is applied in this article to model the statistical behavior of the maximum and minimum temperature distribution tails in four cities of Baja California in northwestern Mexico, using data from 1950-2010. The approach used of the maximum of annual time blocks. Temporal trends were included as covariates in the location parameter (μ), which resulted in significant improvements to the proposed models, particularly for the extreme maximum temperature values in the cities of Mexicali, Tijuana, and Tecate, and the extreme minimum temperature values in Mexicali and Ensenada. These models were used to estimate future probabilities over the next 100 years (2015-2110) for different time periods, and they were compared with changes in the extreme (P90th and P10th) percentiles of maximum and minimum temperature scenarios for a set of six general circulation models under low (RCP4.5) and high (RCP8.5) radiative forcings. By the end of the twenty-first century, the scenarios of the changes in extreme maximum summer temperature are of the same order in both the statistical model and the high radiative scenario (increases of 4-5 °C). The low radiative scenario is more conservative (increases of 2-3 °C). The winter scenario shows that minimum temperatures could be less severe; the temperature increases suggested by the probabilistic model are greater than those projected for the end of the century by the set of global models under RCP4.5 and RCP8.5 scenarios. The likely impacts on the region are discussed.

Temperature-dependent mechanical properties of single-layer molybdenum disulphide: Molecular dynamics nanoindentation simulations

NASA Astrophysics Data System (ADS)

Zhao, Junhua; Jiang, Jin-Wu; Rabczuk, Timon

2013-12-01

The temperature-dependent mechanical properties of single-layer molybdenum disulphide (MoS2) are obtained using molecular dynamics (MD) nanoindentation simulations. The Young's moduli, maximum load stress, and maximum loading strain decrease with increasing temperature from 4.2 K to 500 K. The obtained Young's moduli are in good agreement with those using our MD uniaxial tension simulations and the available experimental results. The tendency of maximum loading strain with different temperature is opposite with that of metal materials due to the short range Stillinger-Weber potentials in MoS2. Furthermore, the indenter tip radius and fitting strain effect on the mechanical properties are also discussed.

Daily mean temperature estimate at the US SUFRAD stations as an average of the maximum and minimum temperatures

DOE PAGES

Chylek, Petr; Augustine, John A.; Klett, James D.; ...

2017-09-30

At thousands of stations worldwide, the mean daily surface air temperature is estimated as a mean of the daily maximum (T max) and minimum (T min) temperatures. In this paper, we use the NOAA Surface Radiation Budget Network (SURFRAD) of seven US stations with surface air temperature recorded each minute to assess the accuracy of the mean daily temperature estimate as an average of the daily maximum and minimum temperatures and to investigate how the accuracy of the estimate increases with an increasing number of daily temperature observations. We find the average difference between the estimate based on an averagemore » of the maximum and minimum temperatures and the average of 1440 1-min daily observations to be - 0.05 ± 1.56 °C, based on analyses of a sample of 238 days of temperature observations. Considering determination of the daily mean temperature based on 3, 4, 6, 12, or 24 daily temperature observations, we find that 2, 4, or 6 daily observations do not reduce significantly the uncertainty of the daily mean temperature. The bias reduction in a statistically significant manner (95% confidence level) occurs only with 12 or 24 daily observations. The daily mean temperature determination based on 24 hourly observations reduces the sample daily temperature uncertainty to - 0.01 ± 0.20 °C. Finally, estimating the parameters of population of all SURFRAD observations, the 95% confidence intervals based on 24 hourly measurements is from - 0.025 to 0.004 °C, compared to a confidence interval from - 0.15 to 0.05 °C based on the mean of T max and T min.« less

Relationships between water temperatures and upstream migration, cold water refuge use, and spawning of adult bull trout from the Lostine River, Oregon, USA

USGS Publications Warehouse

Howell, P.J.; Dunham, J.B.; Sankovich, P.M.

2010-01-01

Understanding thermal habitat use by migratory fish has been limited by difficulties in matching fish locations with water temperatures. To describe spatial and temporal patterns of thermal habitat use by migratory adult bull trout, Salvelinus confluentus, that spawn in the Lostine River, Oregon, we employed a combination of archival temperature tags, radio tags, and thermographs. We also compared temperatures of the tagged fish to ambient water temperatures to determine if the fish were using thermal refuges. The timing and temperatures at which fish moved upstream from overwintering areas to spawning locations varied considerably among individuals. The annual maximum 7-day average daily maximum (7DADM) temperatures of tagged fish were 16-18 ??C and potentially as high as 21 ??C. Maximum 7DADM ambient water temperatures within the range of tagged fish during summer were 18-25 ??C. However, there was no evidence of the tagged fish using localized cold water refuges. Tagged fish appeared to spawn at 7DADM temperatures of 7-14 ??C. Maximum 7DADM temperatures of tagged fish and ambient temperatures at the onset of the spawning period in late August were 11-18 ??C. Water temperatures in most of the upper Lostine River used for spawning and rearing appear to be largely natural since there has been little development, whereas downstream reaches used by migratory bull trout are heavily diverted for irrigation. Although the population effects of these temperatures are unknown, summer temperatures and the higher temperatures observed for spawning fish appear to be at or above the upper range of suitability reported for the species. Published 2009. This article is a US Governmentwork and is in the public domain in the USA.

Daily mean temperature estimate at the US SUFRAD stations as an average of the maximum and minimum temperatures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chylek, Petr; Augustine, John A.; Klett, James D.

At thousands of stations worldwide, the mean daily surface air temperature is estimated as a mean of the daily maximum (T max) and minimum (T min) temperatures. In this paper, we use the NOAA Surface Radiation Budget Network (SURFRAD) of seven US stations with surface air temperature recorded each minute to assess the accuracy of the mean daily temperature estimate as an average of the daily maximum and minimum temperatures and to investigate how the accuracy of the estimate increases with an increasing number of daily temperature observations. We find the average difference between the estimate based on an averagemore » of the maximum and minimum temperatures and the average of 1440 1-min daily observations to be - 0.05 ± 1.56 °C, based on analyses of a sample of 238 days of temperature observations. Considering determination of the daily mean temperature based on 3, 4, 6, 12, or 24 daily temperature observations, we find that 2, 4, or 6 daily observations do not reduce significantly the uncertainty of the daily mean temperature. The bias reduction in a statistically significant manner (95% confidence level) occurs only with 12 or 24 daily observations. The daily mean temperature determination based on 24 hourly observations reduces the sample daily temperature uncertainty to - 0.01 ± 0.20 °C. Finally, estimating the parameters of population of all SURFRAD observations, the 95% confidence intervals based on 24 hourly measurements is from - 0.025 to 0.004 °C, compared to a confidence interval from - 0.15 to 0.05 °C based on the mean of T max and T min.« less

Mid-depth temperature maximum in an estuarine lake

NASA Astrophysics Data System (ADS)

Stepanenko, V. M.; Repina, I. A.; Artamonov, A. Yu; Gorin, S. L.; Lykossov, V. N.; Kulyamin, D. V.

2018-03-01

The mid-depth temperature maximum (TeM) was measured in an estuarine Bol’shoi Vilyui Lake (Kamchatka peninsula, Russia) in summer 2015. We applied 1D k-ɛ model LAKE to the case, and found it successfully simulating the phenomenon. We argue that the main prerequisite for mid-depth TeM development is a salinity increase below the freshwater mixed layer, sharp enough in order to increase the temperature with depth not to cause convective mixing and double diffusion there. Given that this condition is satisfied, the TeM magnitude is controlled by physical factors which we identified as: radiation absorption below the mixed layer, mixed-layer temperature dynamics, vertical heat conduction and water-sediments heat exchange. In addition to these, we formulate the mechanism of temperature maximum ‘pumping’, resulting from the phase shift between diurnal cycles of mixed-layer depth and temperature maximum magnitude. Based on the LAKE model results we quantify the contribution of the above listed mechanisms and find their individual significance highly sensitive to water turbidity. Relying on physical mechanisms identified we define environmental conditions favouring the summertime TeM development in salinity-stratified lakes as: small-mixed layer depth (roughly, ~< 2 m), transparent water, daytime maximum of wind and cloudless weather. We exemplify the effect of mixed-layer depth on TeM by a set of selected lakes.

Canadian crop calendars in support of the early warning project

NASA Technical Reports Server (NTRS)

Trenchard, M. H.; Hodges, T. (Principal Investigator)

1980-01-01

The Canadian crop calendars for LACIE are presented. Long term monthly averages of daily maximum and daily minimum temperatures for subregions of provinces were used to simulate normal daily maximum and minimum temperatures. The Robertson (1968) spring wheat and Williams (1974) spring barley phenology models were run using the simulated daily temperatures and daylengths for appropriate latitudes. Simulated daily temperatures and phenology model outputs for spring wheat and spring barley are given.

Effect of temperature and dissolved oxygen on biological nitrification at high ammonia concentrations.

PubMed

Weon, S Y; Lee, S I; Koopman, B

2004-11-01

Effect of temperature and dissolved oxygen concentration on nitrification rate were investigated with enrichment cultures of nitrifying bacteria. Values of specific nitrite oxidation rate in the absence of ammonia were 2.9-12 times higher than maximum specific ammonia oxidation rates at the same temperatures. The presence of high ammonia levels reversed this relationship, causing maximum specific nitrite oxidation rates to fall to 19 to 45% as high as maximum specific ammonia oxidation rates. This result suggests that nitrification at high ammonia levels will invariably result in nitrite accumulation. The K(O2) for nitrite oxidation in the presence of high ammonia levels was higher than the K(O2) for ammonia oxidation when temperature exceeded 18 degrees C, whereas the opposite was true at lower temperatures. These results indicate that low oxygen tensions will exacerbate nitrite accumulation when water temperature is high.

Extreme Maximum Land Surface Temperatures.

NASA Astrophysics Data System (ADS)

Garratt, J. R.

1992-09-01

There are numerous reports in the literature of observations of land surface temperatures. Some of these, almost all made in situ, reveal maximum values in the 50°-70°C range, with a few, made in desert regions, near 80°C. Consideration of a simplified form of the surface energy balance equation, utilizing likely upper values of absorbed shortwave flux (1000 W m2) and screen air temperature (55°C), that surface temperatures in the vicinity of 90°-100°C may occur for dry, darkish soils of low thermal conductivity (0.1-0.2 W m1 K1). Numerical simulations confirm this and suggest that temperature gradients in the first few centimeters of soil may reach 0.5°-1°C mm1 under these extreme conditions. The study bears upon the intrinsic interest of identifying extreme maximum temperatures and yields interesting information regarding the comfort zone of animals (including man).

Resilience of rice (Oryza spp.) pollen germination and tube growth to temperature stress.

PubMed

Coast, Onoriode; Murdoch, Alistair J; Ellis, Richard H; Hay, Fiona R; Jagadish, Krishna S V

2016-01-01

Resilience of rice cropping systems to potential global climate change will partly depend on the temperature tolerance of pollen germination (PG) and tube growth (PTG). Pollen germination of high temperature-susceptible Oryza glaberrima Steud. (cv. CG14) and Oryza sativa L. ssp. indica (cv. IR64) and high temperature-tolerant O. sativa ssp. aus (cv. N22), was assessed on a 5.6-45.4 °C temperature gradient system. Mean maximum PG was 85% at 27 °C with 1488 μm PTG at 25 °C. The hypothesis that in each pollen grain, the minimum temperature requirements (Tn ) and maximum temperature limits (Tx ) for germination operate independently was accepted by comparing multiplicative and subtractive probability models. The maximum temperature limit for PG in 50% of grains (Tx(50) ) was the lowest (29.8 °C) in IR64 compared with CG14 (34.3 °C) and N22 (35.6 °C). Standard deviation (sx ) of Tx was also low in IR64 (2.3 °C) suggesting that the mechanism of IR64's susceptibility to high temperatures may relate to PG. Optimum germination temperatures and thermal times for 1 mm PTG were not linked to tolerating high temperatures at anthesis. However, the parameters Tx(50) and sx in the germination model define new pragmatic criteria for successful and resilient PG, preferable to the more traditional cardinal (maximum and minimum) temperatures. © 2014 John Wiley & Sons Ltd.

Recurrence quantification analysis of extremes of maximum and minimum temperature patterns for different climate scenarios in the Mesochora catchment in Central-Western Greece

NASA Astrophysics Data System (ADS)

Panagoulia, Dionysia; Vlahogianni, Eleni I.

2018-06-01

A methodological framework based on nonlinear recurrence analysis is proposed to examine the historical data evolution of extremes of maximum and minimum daily mean areal temperature patterns over time under different climate scenarios. The methodology is based on both historical data and atmospheric General Circulation Model (GCM) produced climate scenarios for the periods 1961-2000 and 2061-2100 which correspond to 1 × CO2 and 2 × CO2 scenarios. Historical data were derived from the actual daily observations coupled with atmospheric circulation patterns (CPs). The dynamics of the temperature was reconstructed in the phase-space from the time series of temperatures. The statistically comparing different temperature patterns were based on some discriminating statistics obtained by the Recurrence Quantification Analysis (RQA). Moreover, the bootstrap method of Schinkel et al. (2009) was adopted to calculate the confidence bounds of RQA parameters based on a structural preserving resampling. The overall methodology was implemented to the mountainous Mesochora catchment in Central-Western Greece. The results reveal substantial similarities between the historical maximum and minimum daily mean areal temperature statistical patterns and their confidence bounds, as well as the maximum and minimum temperature patterns in evolution under the 2 × CO2 scenario. A significant variability and non-stationary behaviour characterizes all climate series analyzed. Fundamental differences are produced from the historical and maximum 1 × CO2 scenarios, the maximum 1 × CO2 and minimum 1 × CO2 scenarios, as well as the confidence bounds for the two CO2 scenarios. The 2 × CO2 scenario reflects the strongest shifts in intensity, duration and frequency in temperature patterns. Such transitions can help the scientists and policy makers to understand the effects of extreme temperature changes on water resources, economic development, and health of ecosystems and hence to proceed to effective proactive management of extreme phenomena. The impacts of the findings on the predictability of the extreme daily mean areal temperature patterns are also commented.

Effect of daily environmental temperature on farrowing rate and total born in dam line sows.

PubMed

Bloemhof, S; Mathur, P K; Knol, E F; van der Waaij, E H

2013-06-01

Heat stress is known to adversely affect reproductive performance of sows. However, it is important to know on which days or periods during the reproduction cycle heat stress has the greatest effects for designing appropriate genetic or management strategies. Therefore, this study was conducted to identify days and periods that have greatest effects on farrowing rate and total born of sows using 5 different measures of heat stress. The data consisted of 22,750 records on 5024 Dutch Yorkshire dam line sows from 16 farms in Spain and Portugal. Heat stress on a given day was measured in terms of maximum temperature, diurnal temperature range and heat load. The heat load was estimated using 3 definitions considering different upper critical temperatures. Identification of days during the reproduction cycle that had maximum effect was based on the Pearson correlation between the heat stress variable and the reproduction trait, estimated for each day during the reproduction cycle. Polynomial functions were fitted to describe the trends of these correlations and the days with greatest negative correlation were considered as days with maximum effect. Correlations were greatest for maximum temperature, followed by those for heat load and diurnal temperature range. Correlations for both farrowing rate and total born were stronger in gilts than in sows. This implies that heat stress has a stronger effect on reproductive performance of gilts than of sows. Heat stress during the third week (21 to 14 d) before first insemination had largest effect on farrowing rate. Heat stress during the period between 7 d before successful insemination until 12 d after that had largest effect on total born. Correlations between temperatures on consecutive days during these periods were extremely high ( > 0.9). Therefore, for farrowing rate the maximum temperature on 21 d before first insemination and for total born the maximum temperature at day of successful insemination can be used as predictive measures of heat stress in commercial sow farms. Additionally, differences between daughter groups of sires were identified in response to high temperatures. This might indicate possibilities for genetic selection on heat tolerance.

Factors affecting the estimate of primary production from space

NASA Technical Reports Server (NTRS)

Balch, W. M.; Byrne, C. F.

1994-01-01

Remote sensing of primary production in the euphotic zone has been based mostly on visible-band and water-leaving radiance measured with the coastal zone color scanner. There are some robust, simple relationships for calculating integral production based on surface measurements, but they also require knowledge for photoadaptive parameters such as maximum photosynthesis which currently cannot be obtained from spave. A 17,000-station data set is used to show that space-based estimates of maximum photosynthesis could improve predictions of psi, the water column light utiliztion index, which is an important term in many primary productivity models. Temperature is also examined as a factor for predicting hydrographic structure and primary production. A simple model is used to relate temperature and maximum photosynthesis; the model incorporates (1) the positive relationship between maximum photosynthesis and temperature and (2) the strongly negative relationship between temperature and nitrate in the ocean (which directly affects maximum growth rates via nitrogen limitation). Since these two factors relate to carbon and nitrogen, 'balanced carbon/nitrogen assimilation' was calculated using the Redfield ratio, It is expected that the relationship between maximum balanced carbon assimilation versus temperature is concave-down, with the peak dependent on nitrate uptake kinetics, temperature-nitrate relationships,a nd the carbon chlorophyll ration. These predictions were compared with the sea truth data. The minimum turnover time for nitrate was also calculated using this approach. Lastly, sea surface temperature gradients were used to predict the slope of isotherms (a proxy for the slope of isopycnals in many waters). Sea truth data show that at size scales of several hundred kilometers, surface temperature gradients can provide information on the slope of isotherms in the top 200 m of the water column. This is directly relevant to the supply of nutrients into the surface mixed layer, which is useful for predicting integral biomass and primary production.

The effect of dryer load on freeze drying process design.

PubMed

Patel, Sajal M; Jameel, Feroz; Pikal, Michael J

2010-10-01

Freeze-drying using a partial load is a common occurrence during the early manufacturing stages when insufficient amounts of active pharmaceutical ingredient (API) are available. In such cases, the immediate production needs are met by performing lyophilization with less than a full freeze dryer load. However, it is not obvious at what fractional load significant deviations from full load behavior begin. The objective of this research was to systematically study the effects of variation in product load on freeze drying behavior in laboratory, pilot and clinical scale freeze-dryers. Experiments were conducted with 5% mannitol (high heat and mass flux) and 5% sucrose (low heat and mass flux) at different product loads (100%, 50%, 10%, and 2%). Product temperature was measured in edge as well as center vials with thermocouples. Specific surface area (SSA) was measured by BET gas adsorption analysis and residual moisture was measured by Karl Fischer. In the lab scale freeze-dryer, the molar flux of inert gas was determined by direct flow measurement using a flowmeter and the molar flux of water vapor was determined by manometric temperature measurement (MTM) and tunable diode laser absorption spectroscopy (TDLAS) techniques. Comparative pressure measurement (capacitance manometer vs. Pirani) was used to determine primary drying time. For both 5% mannitol and 5% sucrose, primary drying time decreases and product temperature increases as the load on the shelves decreases. No systematic variation was observed in residual moisture and vapor composition as load decreased. Further, SSA data suggests that there are no significant freezing differences under different load conditions. Independent of dryer scale, among all the effects, variation in radiation heat transfer from the chamber walls to the product seems to be the dominant effect resulting in shorter primary drying time as the load on the shelf decreases (i.e., the fraction of edge vials increases).

Innate colour preference, individual learning and memory retention in the ant Camponotus blandus.

PubMed

Yilmaz, Ayse; Dyer, Adrian G; Rössler, Wolfgang; Spaethe, Johannes

2017-09-15

Ants are a well-characterized insect model for the study of visual learning and orientation, but the extent to which colour vision is involved in these tasks remains unknown. We investigated the colour preference, learning and memory retention of Camponotus blandus foragers under controlled laboratory conditions. Our results show that C. blandus foragers exhibit a strong innate preference for ultraviolet (UV, 365 nm) over blue (450 nm) and green (528 nm) wavelengths. The ants can learn to discriminate 365 nm from either 528 nm or 450 nm, independent of intensity changes. However, they fail to discriminate between 450 nm and 528 nm. Modelling of putative colour spaces involving different numbers of photoreceptor types revealed that colour discrimination performance of individual ants is best explained by dichromacy, comprising a short-wavelength (UV) receptor with peak sensitivity at about 360 nm, and a long-wavelength receptor with peak sensitivity between 470 nm and 560 nm. Foragers trained to discriminate blue or green from UV light are able to retain the learned colour information in an early mid-term (e-MTM), late mid-term (l-MTM), early long-term (e-LTM) and late long-term (l-LTM) memory from where it can be retrieved after 1 h, 12 h, 24 h, 3 days and 7 days after training, indicating that colour learning may induce different memory phases in ants. Overall, our results show that ants can use chromatic information in a way that should promote efficient foraging in complex natural environments. © 2017. Published by The Company of Biologists Ltd.

Geologic Map of MTM -20012 and -25012 Quadrangles, Margaritifer Terra Region of Mars

USGS Publications Warehouse

Grant, J. A.; Wilson, S.A.; Fortezzo, C.M.; Clark, D.A.

2009-01-01

Mars Transverse Mercator (MTM) -20012 and -25012 quadrangles (lat 17.5 deg - 27.5 deg S., long 345 deg - 350 deg E.) cover a portion of Margaritifer Terra near the east end of Valles Marineris. The map area consists of a diverse assemblage of geologic surfaces including isolated knobs of rugged mountainous material, heavily cratered and dissected ancient highland material, a variety of plains materials, chaotic terrain materials, and one of the highest densities of preserved valleys and their associated deposits on the planet (Saunders, 1979; Baker, 1982; Phillips and others, 2000, 2001). The map area is centered on a degraded, partially filled, ~200-km-diameter impact structure (lat 22 deg S., long 347.5 deg E.), informally referred to as Parana basin, located between Parana Valles to the east and Loire Valles to the west. Parana Valles is a network of multidigitate, mostly east-west-oriented valleys that flowed west and discharged into Parana basin (Grant, 1987, 2000; Grant and Parker, 2002). Loire Valles, broadly comparable in length to the Grand Canyon on Earth, has a deeply incised channel within the map area that originates at the west-northwest edge of Erythraeum Chaos within Parana basin (Grant, 1987, 2000; Grant and Parker, 2002; Strom and others, 2000). Parana and Loire Valles, combined with Samara Valles to the west, form one of the most laterally extensive, well-integrated valley networks on Mars (Grant, 2000) and record a long history of modification by fluvial processes. The origin and morphology of the valley networks, therefore, provide insight into past environmental conditions, whereas their relation with other landforms helps constrain the timing and role of fluvial processes in the evolution and modification of the Margaritifer Terra region.

Forcing mechanism of the seasonally asymmetric quasi-biennial oscillation secondary circulation in ERA-40 and MAECHAM5

NASA Astrophysics Data System (ADS)

Peña-Ortiz, C.; Ribera, P.; García-Herrera, R.; Giorgetta, M. A.; García, R. R.

2008-08-01

The seasonality of the quasi-biennial oscillation (QBO) and its secondary circulation is analyzed in the European Reanalysis (ERA-40) and Middle Atmosphere European Centre Hamburg Model (MAECHAM5) general circulation model data sets through the multitaper method-singular value decomposition (MTM-SVD). In agreement with previous studies, the results reveal a strong seasonal dependence of the QBO secondary circulation. This is characterized by a two-cell structure symmetric about the equator during autumn and spring. However, anomalies strongly weaken in the summer hemisphere and strengthen in the winter hemisphere, leading to an asymmetric QBO secondary circulation characterized by a single-cell structure displaced into the winter hemisphere during the solstices. In ERA-40, this asymmetry is more pronounced during the northern than during the southern winter. These results provide the first observation of the QBO secondary circulation asymmetries in the ERA-40 reanalysis data set across the full stratosphere and the lower mesosphere, up to 0.1 hPa. The MTM-SVD reconstruction of the seasonal QBO signals in the residual circulation and the QBO signals in Eliassen Palm (EP) flux divergences suggest a particular mechanism for the seasonal asymmetries of the QBO secondary circulation and its extension across the midlatitudes. The analysis shows that the QBO modulates the EP flux in the winter hemispheric surf zone poleward of the QBO jets. The zonal wind forcing by EP flux divergence is transformed by the Coriolis effect into a meridional wind signal. The seasonality in the stratospheric EP flux and the hemispheric differences in planetary wave forcing cause the observed seasonality in the QBO secondary circulation and its hemispheric differences.

Centronuclear myopathies: genotype-phenotype correlation and frequency of defined genetic forms in an Italian cohort.

PubMed

Fattori, Fabiana; Maggi, Lorenzo; Bruno, Claudio; Cassandrini, Denise; Codemo, Valentina; Catteruccia, Michela; Tasca, Giorgio; Berardinelli, Angela; Magri, Francesca; Pane, Marika; Rubegni, Anna; Santoro, Lucio; Ruggiero, Lucia; Fiorini, Patrizio; Pini, Antonella; Mongini, Tiziana; Messina, Sonia; Brisca, Giacomo; Colombo, Irene; Astrea, Guja; Fiorillo, Chiara; Bragato, Cinzia; Moroni, Isabella; Pegoraro, Elena; D'Apice, Maria Rosaria; Alfei, Enrico; Mora, Marina; Morandi, Lucia; Donati, Alice; Evilä, Anni; Vihola, Anna; Udd, Bjarne; Bernansconi, Pia; Mercuri, Eugenio; Santorelli, Filippo Maria; Bertini, Enrico; D'Amico, Adele

2015-07-01

Centronuclear myopathies (CNMs) are a group of clinically and genetically heterogeneous muscle disorders. To date, mutation in 7 different genes has been reported to cause CNMs but 30 % of cases still remain genetically undefined. Genetic investigations are often expensive and time consuming. Clinical and morphological clues are needed to facilitate genetic tests and to choose the best approach for genetic screening. We aimed to describe genotype-phenotype correlation in an Italian cohort of patients affected by CNMs, to define the relative frequencies of its defined genetic forms and to draw a diagnostic algorithm to address genetic investigations. We recruited patients with CNMs from all the Italian tertiary neuromuscular centers following clinical and histological criteria. All selected patients were screened for the four 'canonical' genes related to CNMs: MTM1, DNM2, RYR1 and BIN1. Pathogenetic mutations were found in 38 of the 54 screened patients (70 %), mostly in patients with congenital onset (25 of 30 patients, 83 %): 15 in MTM1, 6 in DNM2, 3 in RYR1 and one in TTN. Among the 13 patients with a childhood-adolescence onset, mutations were found in 6 patients (46 %), all in DNM2. In the group of the 11 patients with adult onset, mutations were identified in 7 patients (63 %), again in DNM2, confirming that variants in this gene are relatively more common in late-onset phenotypes. The present study provides the relative molecular frequency of centronuclear myopathy and of its genetically defined forms in Italy and also proposes a diagnostic algorithm to be used in clinical practice to address genetic investigations.

Modeling and predicting the biofilm formation of Salmonella Virchow with respect to temperature and pH.

PubMed

Ariafar, M Nima; Buzrul, Sencer; Akçelik, Nefise

2016-03-01

Biofilm formation of Salmonella Virchow was monitored with respect to time at three different temperature (20, 25 and 27.5 °C) and pH (5.2, 5.9 and 6.6) values. As the temperature increased at a constant pH level, biofilm formation decreased while as the pH level increased at a constant temperature, biofilm formation increased. Modified Gompertz equation with high adjusted determination coefficient (Radj(2)) and low mean square error (MSE) values produced reasonable fits for the biofilm formation under all conditions. Parameters of the modified Gompertz equation could be described in terms of temperature and pH by use of a second order polynomial function. In general, as temperature increased maximum biofilm quantity, maximum biofilm formation rate and time of acceleration of biofilm formation decreased; whereas, as pH increased; maximum biofilm quantity, maximum biofilm formation rate and time of acceleration of biofilm formation increased. Two temperature (23 and 26 °C) and pH (5.3 and 6.3) values were used up to 24 h to predict the biofilm formation of S. Virchow. Although the predictions did not perfectly match with the data, reasonable estimates were obtained. In principle, modeling and predicting the biofilm formation of different microorganisms on different surfaces under various conditions could be possible.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, C. S.; Zhang, Hongbin

Uncertainty quantification and sensitivity analysis are important for nuclear reactor safety design and analysis. A 2x2 fuel assembly core design was developed and simulated by the Virtual Environment for Reactor Applications, Core Simulator (VERA-CS) coupled neutronics and thermal-hydraulics code under development by the Consortium for Advanced Simulation of Light Water Reactors (CASL). An approach to uncertainty quantification and sensitivity analysis with VERA-CS was developed and a new toolkit was created to perform uncertainty quantification and sensitivity analysis with fourteen uncertain input parameters. Furthermore, the minimum departure from nucleate boiling ratio (MDNBR), maximum fuel center-line temperature, and maximum outer clad surfacemore » temperature were chosen as the selected figures of merit. Pearson, Spearman, and partial correlation coefficients were considered for all of the figures of merit in sensitivity analysis and coolant inlet temperature was consistently the most influential parameter. We used parameters as inputs to the critical heat flux calculation with the W-3 correlation were shown to be the most influential on the MDNBR, maximum fuel center-line temperature, and maximum outer clad surface temperature.« less

Uncertainty quantification and sensitivity analysis with CASL Core Simulator VERA-CS

DOE PAGES

Brown, C. S.; Zhang, Hongbin

2016-05-24

Uncertainty quantification and sensitivity analysis are important for nuclear reactor safety design and analysis. A 2x2 fuel assembly core design was developed and simulated by the Virtual Environment for Reactor Applications, Core Simulator (VERA-CS) coupled neutronics and thermal-hydraulics code under development by the Consortium for Advanced Simulation of Light Water Reactors (CASL). An approach to uncertainty quantification and sensitivity analysis with VERA-CS was developed and a new toolkit was created to perform uncertainty quantification and sensitivity analysis with fourteen uncertain input parameters. Furthermore, the minimum departure from nucleate boiling ratio (MDNBR), maximum fuel center-line temperature, and maximum outer clad surfacemore » temperature were chosen as the selected figures of merit. Pearson, Spearman, and partial correlation coefficients were considered for all of the figures of merit in sensitivity analysis and coolant inlet temperature was consistently the most influential parameter. We used parameters as inputs to the critical heat flux calculation with the W-3 correlation were shown to be the most influential on the MDNBR, maximum fuel center-line temperature, and maximum outer clad surface temperature.« less

Effects of EVA gloves on grip strength and fatigue under low temperature and low pressure.

PubMed

Tian, Yinsheng; Ding, Li; Liu, Heqing; Li, Yan; Li, Deyu; Wang, Li

2016-03-01

To study the effects of wearing extravehicular activity (EVA) gloves on grip strength and fatigue in low temperature, low pressure and mixing of two factors (low temperature and low pressure). The maximum grip strength and fatigue tests were performed with 10 healthy male subjects wearing gloves in a variety of simulated environments. The data was analysed using the normalization method. The results showed that wearing gloves significantly affected the maximum grip strength and fatigue. Pressure (29.6, 39.2 kPa) had more influence on the maximum grip compared with control group while low temperatures (-50, -90, -110 °C) had no influence on grip but affected fatigue dramatically. The results also showed that the maximum grip strength and fatigue were influenced significantly in a compound environment. Space environment remarkably reduced strength and endurance of the astronauts. However, the effects brought by the compound environment cannot be understood as the superimposition of low temperature and pressure effects. Copyright © 2015 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Trends in Middle East climate extreme indices from 1950 to 2003

NASA Astrophysics Data System (ADS)

Zhang, Xuebin; Aguilar, Enric; Sensoy, Serhat; Melkonyan, Hamlet; Tagiyeva, Umayra; Ahmed, Nader; Kutaladze, Nato; Rahimzadeh, Fatemeh; Taghipour, Afsaneh; Hantosh, T. H.; Albert, Pinhas; Semawi, Mohammed; Karam Ali, Mohammad; Said Al-Shabibi, Mansoor Halal; Al-Oulan, Zaid; Zatari, Taha; Al Dean Khelet, Imad; Hamoud, Saleh; Sagir, Ramazan; Demircan, Mesut; Eken, Mehmet; Adiguzel, Mustafa; Alexander, Lisa; Peterson, Thomas C.; Wallis, Trevor

2005-11-01

A climate change workshop for the Middle East brought together scientists and data for the region to produce the first area-wide analysis of climate extremes for the region. This paper reports trends in extreme precipitation and temperature indices that were computed during the workshop and additional indices data that became available after the workshop. Trends in these indices were examined for 1950-2003 at 52 stations covering 15 countries, including Armenia, Azerbaijan, Bahrain, Cyprus, Georgia, Iran, Iraq, Israel, Jordan, Kuwait, Oman, Qatar, Saudi Arabia, Syria, and Turkey. Results indicate that there have been statistically significant, spatially coherent trends in temperature indices that are related to temperature increases in the region. Significant, increasing trends have been found in the annual maximum of daily maximum and minimum temperature, the annual minimum of daily maximum and minimum temperature, the number of summer nights, and the number of days where daily temperature has exceeded its 90th percentile. Significant negative trends have been found in the number of days when daily temperature is below its 10th percentile and daily temperature range. Trends in precipitation indices, including the number of days with precipitation, the average precipitation intensity, and maximum daily precipitation events, are weak in general and do not show spatial coherence. The workshop attendees have generously made the indices data available for the international research community.

Temperature induced changes in size dependent distributions of two boreal and three Lusitanian flatfish species: A comparative study

NASA Astrophysics Data System (ADS)

van Hal, Ralf; van Kooten, Tobias; Rijnsdorp, Adriaan D.

2016-01-01

Changes in spatial distribution in several fish species have been related to recent increase in global temperature. In the North Sea, both a poleward shift and a shift to deeper water have been observed. Here, we study the underlying mechanism of these shifts in a comparative study of the changes in distribution of two boreal flatfish species (plaice Pleuronectes platessa and dab Limanda limanda) and three Lusitanian flatfish species (sole Solea solea, solenette Buglossidium luteum, and scaldfish Arnoglossus laterna) as recorded in annual bottom trawl surveys carried out in the North Sea in late summer since 1985. The distribution is analysed in relation to the bottom temperature at the time of the survey as well as to the seasonal maximum bottom temperature earlier in the year. It is shown that the boreal species plaice and dab moved to deeper water and maintained the seasonal maximum temperature that they experienced in earlier periods, while the Lusitanian species sole, solenette, and scaldfish experienced an increase in the seasonal maximum temperature that they experienced while maintaining their depth distribution. This overall response varied between length classes, reflecting a preference for higher temperature of the smaller length classes. The results lend support to the hypothesis that the fish displayed a direct response to the maximum temperature that occurred during the growth season before the time of sampling.

Coolant and ambient temperature control for chillerless liquid cooled data centers

DOEpatents

Chainer, Timothy J.; David, Milnes P.; Iyengar, Madhusudan K.; Parida, Pritish R.; Simons, Robert E.

2016-02-02

Cooling control methods include measuring a temperature of air provided to a plurality of nodes by an air-to-liquid heat exchanger, measuring a temperature of at least one component of the plurality of nodes and finding a maximum component temperature across all such nodes, comparing the maximum component temperature to a first and second component threshold and comparing the air temperature to a first and second air threshold, and controlling a proportion of coolant flow and a coolant flow rate to the air-to-liquid heat exchanger and the plurality of nodes based on the comparisons.

Maximum temperatures of 89°C recorded during the mechanical preparation of 35 femoral heads for resurfacing

PubMed Central

2011-01-01

Background and purpose We noticed that our instruments were often too hot to touch after preparing the femoral head for resurfacing, and questioned whether the heat generated could exceed temperatures known to cause osteonecrosis. Patients and methods Using an infra-red thermal imaging camera, we measured real-time femoral head temperatures during femoral head reaming in 35 patients undergoing resurfacing hip arthroplasty. 7 patients received an ASR, 8 received a Cormet, and 20 received a Birmingham resurfacing arthroplasty. Results The maximum temperature recorded was 89°C. The temperature exceeded 47°C in 28 patients and 70°C in 11. The mean duration of most stages of head preparation was less than 1 min. The mean time exceeded 1 min only on peripheral head reaming of the ASR system. At temperatures lower than 47°C, only 2 femoral heads were exposed long enough to cause osteonecrosis. The highest mean maximum temperatures recorded were 54°C when the proximal femoral head was resected with an oscillating saw and 47°C during peripheral reaming with the crown drill. The modified new Birmingham resurfacing proximal femoral head reamer substantially reduced the maximum temperatures generated. Lavage reduced temperatures to a mean of 18°C. Interpretation 11 patients were subjected to temperatures sufficient to cause osteonecrosis secondary to thermal insult, regardless of the duration of reaming. In 2 cases only, the length of reaming was long enough to induce damage at lower temperatures. Lavage and sharp instruments should reduce the risk of thermal insult during hip resurfacing. PMID:22066558

Spatial statistical network models for stream and river temperature in New England, USA

NASA Astrophysics Data System (ADS)

Detenbeck, Naomi E.; Morrison, Alisa C.; Abele, Ralph W.; Kopp, Darin A.

2016-08-01

Watershed managers are challenged by the need for predictive temperature models with sufficient accuracy and geographic breadth for practical use. We described thermal regimes of New England rivers and streams based on a reduced set of metrics for the May-September growing season (July or August median temperature, diurnal rate of change, and magnitude and timing of growing season maximum) chosen through principal component analysis of 78 candidate metrics. We then developed and assessed spatial statistical models for each of these metrics, incorporating spatial autocorrelation based on both distance along the flow network and Euclidean distance between points. Calculation of spatial autocorrelation based on travel or retention time in place of network distance yielded tighter-fitting Torgegrams with less scatter but did not improve overall model prediction accuracy. We predicted monthly median July or August stream temperatures as a function of median air temperature, estimated urban heat island effect, shaded solar radiation, main channel slope, watershed storage (percent lake and wetland area), percent coarse-grained surficial deposits, and presence or maximum depth of a lake immediately upstream, with an overall root-mean-square prediction error of 1.4 and 1.5°C, respectively. Growing season maximum water temperature varied as a function of air temperature, local channel slope, shaded August solar radiation, imperviousness, and watershed storage. Predictive models for July or August daily range, maximum daily rate of change, and timing of growing season maximum were statistically significant but explained a much lower proportion of variance than the above models (5-14% of total).

Evaluation of extreme temperature events in northern Spain based on process control charts

NASA Astrophysics Data System (ADS)

Villeta, M.; Valencia, J. L.; Saá, A.; Tarquis, A. M.

2018-02-01

Extreme climate events have recently attracted the attention of a growing number of researchers because these events impose a large cost on agriculture and associated insurance planning. This study focuses on extreme temperature events and proposes a new method for their evaluation based on statistical process control tools, which are unusual in climate studies. A series of minimum and maximum daily temperatures for 12 geographical areas of a Spanish region between 1931 and 2009 were evaluated by applying statistical process control charts to statistically test whether evidence existed for an increase or a decrease of extreme temperature events. Specification limits were determined for each geographical area and used to define four types of extreme anomalies: lower and upper extremes for the minimum and maximum anomalies. A new binomial Markov extended process that considers the autocorrelation between extreme temperature events was generated for each geographical area and extreme anomaly type to establish the attribute control charts for the annual fraction of extreme days and to monitor the occurrence of annual extreme days. This method was used to assess the significance of changes and trends of extreme temperature events in the analysed region. The results demonstrate the effectiveness of an attribute control chart for evaluating extreme temperature events. For example, the evaluation of extreme maximum temperature events using the proposed statistical process control charts was consistent with the evidence of an increase in maximum temperatures during the last decades of the last century.

The Effects of Engine Speed and Mixture Temperature on the Knocking Characteristics of Several Fuels

NASA Technical Reports Server (NTRS)

Lee, Dana W

1940-01-01

Six 100-octane and two 87-octane aviation engine fuels were tested in a modified C.F.R. variable-compression engine at 1,500, 2,000 and 2,500 rpm. The mixture temperature was raised from 50 to 300 F in approximately 50 degree steps and, at each temperature, the compression ratio was adjusted to give incipient knock as shown by a cathode ray indicator. The results are presented in tabular form. The results are analyzed on the assumption that the conditions which determine whether a given fuel will knock are the maximum values of density and temperature reached by the burning gases. A maximum permissible density factor, proportional to the maximum density of the burning gases just prior to incipient knock, and the temperature of the burning gases at that time were computed for each of the test conditions. Values of the density factors were plotted against the corresponding end-gas temperatures for the three engine speeds and also against engine speed for several and end-gas temperatures. The maximum permissible density factor varied only slightly with engine speed but decreased rapidly with an increase in the end-gas temperature. The effect of changing the mixture temperature was different for fuels of different types. The results emphasize the desirability of determining the anti knock values of fuels over a wide range of engine and intake-air conditions rather that at a single set of conditions.

Operational forecasting of daily temperatures in the Valencia Region. Part I: maximum temperatures in summer.

NASA Astrophysics Data System (ADS)

Gómez, I.; Estrela, M.

2009-09-01

Extreme temperature events have a great impact on human society. Knowledge of summer maximum temperatures is very useful for both the general public and organisations whose workers have to operate in the open, e.g. railways, roadways, tourism, etc. Moreover, summer maximum daily temperatures are considered a parameter of interest and concern since persistent heat-waves can affect areas as diverse as public health, energy consumption, etc. Thus, an accurate forecasting of these temperatures could help to predict heat-wave conditions and permit the implementation of strategies aimed at minimizing the negative effects that high temperatures have on human health. The aim of this work is to evaluate the skill of the RAMS model in determining daily maximum temperatures during summer over the Valencia Region. For this, we have used the real-time configuration of this model currently running at the CEAM Foundation. To carry out the model verification process, we have analysed not only the global behaviour of the model for the whole Valencia Region, but also its behaviour for the individual stations distributed within this area. The study has been performed for the summer forecast period of 1 June - 30 September, 2007. The results obtained are encouraging and indicate a good agreement between the observed and simulated maximum temperatures. Moreover, the model captures quite well the temperatures in the extreme heat episodes. Acknowledgement. This work was supported by "GRACCIE" (CSD2007-00067, Programa Consolider-Ingenio 2010), by the Spanish Ministerio de Educación y Ciencia, contract number CGL2005-03386/CLI, and by the Regional Government of Valencia Conselleria de Sanitat, contract "Simulación de las olas de calor e invasiones de frío y su regionalización en la Comunidad Valenciana" ("Heat wave and cold invasion simulation and their regionalization at Valencia Region"). The CEAM Foundation is supported by the Generalitat Valenciana and BANCAIXA (Valencia, Spain).

Thermal design of composite material high temperature attachments

NASA Technical Reports Server (NTRS)

1972-01-01

An evaluation has been made of the thermal aspects of utilizing advanced filamentary composite materials as primary structures on the shuttle vehicle. The technical objectives of this study are to: (1) establish and design concepts for maintaining material temperatures within allowable limits at TPS attachments and or penetrations applicable to the space shuttle; and (2) verify the thermal design analysis by testing selected concepts. Specific composite materials being evaluated are boron epoxy, graphite/epoxy, boron polyimide, and boron aluminum; graphite/polyimide has been added to this list for property data identification and preliminary evaluation of thermal design problems. The TPS standoff to composite structure attachment over-temperature problem is directly related to TPS maximum surface temperature. To provide a thermally comprehensive evaluation of attachment temperature characteristics, maximum surface temperatures of 900 F, 1200 F, 1800 F, 2500 F and 3000 F are considered in this study. This range of surface temperatures and the high and low maximum temperature capability of the selected composite materials will result in a wide range of thermal requirements for composite/TPS standoff attachments.

Thermal stability analysis under embankment with asphalt pavement and cement pavement in permafrost regions.

PubMed

Junwei, Zhang; Jinping, Li; Xiaojuan, Quan

2013-01-01

The permafrost degradation is the fundamental cause generating embankment diseases and pavement diseases in permafrost region while the permafrost degradation is related with temperature. Based on the field monitoring results of ground temperature along G214 Highway in high temperature permafrost regions, both the ground temperatures in superficial layer and the annual average temperatures under the embankment were discussed, respectively, for concrete pavements and asphalt pavements. The maximum depth of temperature field under the embankment for concrete pavements and asphalt pavements was also studied by using the finite element method. The results of numerical analysis indicate that there were remarkable seasonal differences of the ground temperatures in superficial layer between asphalt pavement and concrete pavement. The maximum influencing depth of temperature field under the permafrost embankment for every pavement was under the depth of 8 m. The thawed cores under both embankments have close relation with the maximum thawed depth, the embankment height, and the service time. The effective measurements will be proposed to keep the thermal stabilities of highway embankment by the results.

Thermal Stability Analysis under Embankment with Asphalt Pavement and Cement Pavement in Permafrost Regions

PubMed Central

Jinping, Li; Xiaojuan, Quan

2013-01-01

The permafrost degradation is the fundamental cause generating embankment diseases and pavement diseases in permafrost region while the permafrost degradation is related with temperature. Based on the field monitoring results of ground temperature along G214 Highway in high temperature permafrost regions, both the ground temperatures in superficial layer and the annual average temperatures under the embankment were discussed, respectively, for concrete pavements and asphalt pavements. The maximum depth of temperature field under the embankment for concrete pavements and asphalt pavements was also studied by using the finite element method. The results of numerical analysis indicate that there were remarkable seasonal differences of the ground temperatures in superficial layer between asphalt pavement and concrete pavement. The maximum influencing depth of temperature field under the permafrost embankment for every pavement was under the depth of 8 m. The thawed cores under both embankments have close relation with the maximum thawed depth, the embankment height, and the service time. The effective measurements will be proposed to keep the thermal stabilities of highway embankment by the results. PMID:24027444

The Effects of Data Gaps on the Calculated Monthly Mean Maximum and Minimum Temperatures in the Continental United States: A Spatial and Temporal Study.

NASA Astrophysics Data System (ADS)

Stooksbury, David E.; Idso, Craig D.; Hubbard, Kenneth G.

1999-05-01

Gaps in otherwise regularly scheduled observations are often referred to as missing data. This paper explores the spatial and temporal impacts that data gaps in the recorded daily maximum and minimum temperatures have on the calculated monthly mean maximum and minimum temperatures. For this analysis 138 climate stations from the United States Historical Climatology Network Daily Temperature and Precipitation Data set were selected. The selected stations had no missing maximum or minimum temperature values during the period 1951-80. The monthly mean maximum and minimum temperatures were calculated for each station for each month. For each month 1-10 consecutive days of data from each station were randomly removed. This was performed 30 times for each simulated gap period. The spatial and temporal impact of the 1-10-day data gaps were compared. The influence of data gaps is most pronounced in the continental regions during the winter and least pronounced in the southeast during the summer. In the north central plains, 10-day data gaps during January produce a standard deviation value greater than 2°C about the `true' mean. In the southeast, 10-day data gaps in July produce a standard deviation value less than 0.5°C about the mean. The results of this study will be of value in climate variability and climate trend research as well as climate assessment and impact studies.

40 CFR 60.116b - Monitoring of operations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... range. (e) Available data on the storage temperature may be used to determine the maximum true vapor...: (i) Available data on the Reid vapor pressure and the maximum expected storage temperature based on... Liquid Storage Vessels (Including Petroleum Liquid Storage Vessels) for Which Construction...

Designing Ground Antennas for Maximum G/T: Cassegrain or Gregorian?

NASA Technical Reports Server (NTRS)

Imbriale, William A.

2005-01-01

For optimum performance, a ground antenna system must maximize the ratio of received signal to the receiving system noise power, defined as the ratio of antenna gain to system-noise temperature (G/T). The total system noise temperature is the linear combination of the receiver noise temperature (including the feed system losses) and the antenna noise contribution. Hence, for very low noise cryogenic receiver systems, antenna noise-temperature properties are very significant contributors to G/T.It is well known that, for dual reflector systems designed for maximum gain, the gain performance of the antenna system is the same for both Cassegrain and Gregorian configurations. For a12-meter antenna designed to be part of the large array based Deep Space Network, a Cassegrain configuration designed for maximum G/T at X-band was 0.7 dB higher than the equivalent Gregorian configuration. This study demonstrates that, for maximum GIT, the dual shaped Cassegrain design is always better than the Gregorian.

MRI Evidence of Endolymphatic Impermeability to the Gadolinium Molecule in the In Vivo Mouse Inner Ear at 9.4 Tesla

PubMed Central

Counter, S Allen; Nikkhou, Sahar; Brené, Stefan; Damberg, Peter; Sierakowiak, Adam; Klason, Tomas; Berglin, Cecilia Engmér; Laurell, Göran

2013-01-01

Objective: Previous in vivo experimental magnetic resonance imaging (MRI) investigations of the mammalian inner ear at 4.7 Tesla have indicated that intravenously injected gadolinium (Gd) penetrates the perilymphatic labyrinth, but not the endolymphatic membranous labyrinth. In the present study, high field MRI at 9.4T was used to visualize the in vivo mouse vestibulo-cochlea system, and to determine whether the endolymphatic system is permeable to a Gd complex. Methods: A 9.4 T Varian magnet equipped with a 12 cm inner diameter gradient system with maximum gradient strength of 600 mT/m, a millipede coil (Varian design) and a Gd contrast agent were used for image acquisition in the normal C57 BL-6 mouse. Results: High-resolution 2D and 3D images of the mouse cochlea were acquired within 80 minutes following intravenous injection of Gd. Gd initially permeated the perilymphatic scala tympani and scala vestibuli, and permitted visualization of both cochlear turns from base to apex. The superior, inferior and lateral semicircular canals were subsequently visualized in 3 planes. The membranous endolymphatic labyrinth was impermeable to intravenously injected Gd, and thus showed no apparent uptake of Gd at 9.4T. Conclusion: The 9.4T field strength MRI permitted acquisition of high resolution images of anatomical and physiological features of the normal, wild type mouse perilymphatic inner ear in vivo, and provided further evidence that the endolymphatic system is impermeable to intravenously injected Gd. PMID:23894262

Is applicable thermodynamics of negative temperature for living organisms?

NASA Astrophysics Data System (ADS)

Atanasov, Atanas Todorov

2017-11-01

During organismal development the moment of sexual maturity can be characterizes by nearly maximum basal metabolic rate and body mass. Once the living organism reaches extreme values of the mass and the basal metabolic rate, it reaches near equilibrium thermodynamic steady state physiological level with maximum organismal complexity. Such thermodynamic systems that reach equilibrium steady state level at maximum mass-energy characteristics can be regarded from the prospective of thermodynamics of negative temperature. In these systems the increase of the internal and free energy is accompanied with decrease of the entropy. In our study we show the possibility the living organisms to regard as thermodynamic system with negative temperature

Probabilistic measures of climate change vulnerability, adaptation action benefits, and related uncertainty from maximum temperature metric selection.

PubMed

DeWeber, Jefferson T; Wagner, Tyler

2018-06-01

Predictions of the projected changes in species distributions and potential adaptation action benefits can help guide conservation actions. There is substantial uncertainty in projecting species distributions into an unknown future, however, which can undermine confidence in predictions or misdirect conservation actions if not properly considered. Recent studies have shown that the selection of alternative climate metrics describing very different climatic aspects (e.g., mean air temperature vs. mean precipitation) can be a substantial source of projection uncertainty. It is unclear, however, how much projection uncertainty might stem from selecting among highly correlated, ecologically similar climate metrics (e.g., maximum temperature in July, maximum 30-day temperature) describing the same climatic aspect (e.g., maximum temperatures) known to limit a species' distribution. It is also unclear how projection uncertainty might propagate into predictions of the potential benefits of adaptation actions that might lessen climate change effects. We provide probabilistic measures of climate change vulnerability, adaptation action benefits, and related uncertainty stemming from the selection of four maximum temperature metrics for brook trout (Salvelinus fontinalis), a cold-water salmonid of conservation concern in the eastern United States. Projected losses in suitable stream length varied by as much as 20% among alternative maximum temperature metrics for mid-century climate projections, which was similar to variation among three climate models. Similarly, the regional average predicted increase in brook trout occurrence probability under an adaptation action scenario of full riparian forest restoration varied by as much as .2 among metrics. Our use of Bayesian inference provides probabilistic measures of vulnerability and adaptation action benefits for individual stream reaches that properly address statistical uncertainty and can help guide conservation actions. Our study demonstrates that even relatively small differences in the definitions of climate metrics can result in very different projections and reveal high uncertainty in predicted climate change effects. © 2018 John Wiley & Sons Ltd.

Probabilistic measures of climate change vulnerability, adaptation action benefits, and related uncertainty from maximum temperature metric selection

USGS Publications Warehouse

DeWeber, Jefferson T.; Wagner, Tyler

2018-01-01

Predictions of the projected changes in species distributions and potential adaptation action benefits can help guide conservation actions. There is substantial uncertainty in projecting species distributions into an unknown future, however, which can undermine confidence in predictions or misdirect conservation actions if not properly considered. Recent studies have shown that the selection of alternative climate metrics describing very different climatic aspects (e.g., mean air temperature vs. mean precipitation) can be a substantial source of projection uncertainty. It is unclear, however, how much projection uncertainty might stem from selecting among highly correlated, ecologically similar climate metrics (e.g., maximum temperature in July, maximum 30‐day temperature) describing the same climatic aspect (e.g., maximum temperatures) known to limit a species’ distribution. It is also unclear how projection uncertainty might propagate into predictions of the potential benefits of adaptation actions that might lessen climate change effects. We provide probabilistic measures of climate change vulnerability, adaptation action benefits, and related uncertainty stemming from the selection of four maximum temperature metrics for brook trout (Salvelinus fontinalis), a cold‐water salmonid of conservation concern in the eastern United States. Projected losses in suitable stream length varied by as much as 20% among alternative maximum temperature metrics for mid‐century climate projections, which was similar to variation among three climate models. Similarly, the regional average predicted increase in brook trout occurrence probability under an adaptation action scenario of full riparian forest restoration varied by as much as .2 among metrics. Our use of Bayesian inference provides probabilistic measures of vulnerability and adaptation action benefits for individual stream reaches that properly address statistical uncertainty and can help guide conservation actions. Our study demonstrates that even relatively small differences in the definitions of climate metrics can result in very different projections and reveal high uncertainty in predicted climate change effects.

Unit Fire Direction Center Training Program for the 81mm Mortar

DTIC Science & Technology

1985-02-01

rotor* It to IM Ui. Army ftoioardi instltuto for IM üEaotOfH ond It It «0 Motor NMM. *•••• «o not Sod «« fctonoM. WQTt, Thrt «oiMrcfi *OOMCI * m« to...Virginia 22333-5600 REPORT * PERIOD COVERCO Interim Report June 1983-June 1984 «. PERFORMING OR6. REPORT NUMBER I. CONTRACT OR GRANT NUMBCRf«) MDA ...command for the FFE? A B C D riet Mc M&- 3§± sec MTM. rat US SM tffl sm. mi Htll Iff TMt ! EZ9 E3B NOTE: EOM, mark as Tgt CD 06

Geologic history of central Chryse Planitia and the Viking 1 landing site, Mars

NASA Technical Reports Server (NTRS)

Craddock, Robert A.; Crumpler, L. S.; Aubele, Jayne C.

1993-01-01

A 1:500,000 scale geologic mapping was undertaken to synthesize the broad-scale geology of Chryse Planitia with the local geology of the Viking 1 landing site. The geology of Mars Transverse Mercators (MTM's) 20047 and 25047 has been presented previously. As part of the goals for the Mars Geologic Mapping program, the rational and scientific objectives for a return mission to Chryse Planitia and the Viking 1 Lander have also been presented. However, in mapping central Chryse Planitia our principle objective was to determine the depositional and erosional history of the Chryse Planitia basin. These results are presented.

Geology of -30247, -35247, and -40247 Quadrangles, Southern Hesperia Planum, Mars

NASA Technical Reports Server (NTRS)

Mest, S. C.; Crown, D. A.

2010-01-01

Geologic mapping of MTM -30247, -35247, and -40247 quadrangles is being used to characterize Reull Vallis (RV) and examine the roles and timing of volatile-driven erosional and depositional processes. This study complements earlier investigations of the eastern Hellas region, including regional analyses [1-6], mapping studies of circum-Hellas canyons [7-10], and volcanic studies of Hadriaca and Tyrrhena Paterae [11-13]. Key scientific objectives include 1) characterizing RV in its "fluvial zone," and evaluating its history of formation, 2) analyzing channels in the surrounding plains and potential connections to RV, and 3) examining young, possibly sedimentary plains along RV.

14 CFR 33.84 - Engine overtorque test.

Code of Federal Regulations, 2012 CFR

2012-01-01

... STANDARDS: AIRCRAFT ENGINES Block Tests; Turbine Aircraft Engines § 33.84 Engine overtorque test. (a) If approval of a maximum engine overtorque is sought for an engine incorporating a free power turbine... turbine entry gas temperature equal to the maximum steady state temperature approved for use during...

Temperature and molecular-weight dependences of acoustic behaviors of polystyrene studied using Brillouin spectroscopy

NASA Astrophysics Data System (ADS)

Oh, Soo Han; Lee, Byoung Wan; Ko, Jae-Hyeon; Lee, Hyeonju; Park, Jaehoon; Ko, Young Ho; Kim, Kwang Joo

2017-04-01

The acoustic properties of three polystyrene polymers with different molecular weights were investigated as a function of temperature by using Brillouin light scattering. The longitudinal sound velocity showed a change in the slope, which depended on the molecular weight, at the glass transition temperature. The absorption coefficient exhibited a maximum above the glass transition temperature, and the maximum temperature became higher as the molecular weight was increased. Comparison with previous acoustic studies on polystyrene indicate that a substantial frequency dispersion caused by strong coupling between the longitudinal acoustic waves and the segmental motions exists in the high-temperature range.

Coolant and ambient temperature control for chillerless liquid cooled data centers

DOEpatents

Chainer, Timothy J.; David, Milnes P.; Iyengar, Madhusudan K.; Parida, Pritish R.; Simons, Robert E.

2017-08-29

Cooling control methods and systems include measuring a temperature of air provided to one or more nodes by an air-to-liquid heat exchanger; measuring a temperature of at least one component of the one or more nodes and finding a maximum component temperature across all such nodes; comparing the maximum component temperature to a first and second component threshold and comparing the air temperature to a first and second air threshold; and controlling a proportion of coolant flow and a coolant flow rate to the air-to-liquid heat exchanger and the one or more nodes based on the comparisons.

The comparison of thermal tissue injuries caused by ultrasonic scalpel and electrocautery use in rabbit tongue tissue

PubMed Central

Beriat, Guclu Kaan; Akmansu, Sefik Halit; Ezerarslan, Hande; Dogan, Cem; Han, Unsal; Saglam, Mehmet; Senel, Oytun Okan; Kocaturk, Sinan

2012-01-01

The aim of this study compares to the increase in tissue temperature and the thermal histological effects of ultrasonic scalpel, bipolar and unipolar electrosurgery incisions in the tongue tissue of rabbits. This study evaluates the histopathological changes related to thermal change and the maximum temperature values in the peripheral tissue brought about by the incisions carried out by the three methods in a comparative way. To assess thermal tissue damage induced by the three instruments, maximum tissue temperatures were measured during the surgical procedure and tongue tissue samples were examined histopathologically following the surgery. The mean maximum temperature values of the groups were 93.93±2.76 C° for the unipolar electrocautery group, whereas 85.07±5.95 C° for the bipolar electrocautery group, and 108.23±7.64 C° for the ultrasonic scalpel group. There was a statistically significant relationship between the increase in maximum temperature values and the separation among tissue layers, edema, congestion, necrosis, hemorrhage, destruction in blood vessel walls and fibrin accumulation, and between the existence of fibrin thrombus and tissue damage depth (p<0.05). It was concluded that the bipolar electrocautery use gives way to less temperature increase in the tissues and less thermal tissue damage in comparison to the other methods. PMID:22938541

Statistical assessment of changes in extreme maximum temperatures over Saudi Arabia, 1985-2014

NASA Astrophysics Data System (ADS)

Raggad, Bechir

2018-05-01

In this study, two statistical approaches were adopted in the analysis of observed maximum temperature data collected from fifteen stations over Saudi Arabia during the period 1985-2014. In the first step, the behavior of extreme temperatures was analyzed and their changes were quantified with respect to the Expert Team on Climate Change Detection Monitoring indices. The results showed a general warming trend over most stations, in maximum temperature-related indices, during the period of analysis. In the second step, stationary and non-stationary extreme-value analyses were conducted for the temperature data. The results revealed that the non-stationary model with increasing linear trend in its location parameter outperforms the other models for two-thirds of the stations. Additionally, the 10-, 50-, and 100-year return levels were found to change with time considerably and that the maximum temperature could start to reappear in the different T-year return period for most stations. This analysis shows the importance of taking account the change over time in the estimation of return levels and therefore justifies the use of the non-stationary generalized extreme value distribution model to describe most of the data. Furthermore, these last findings are in line with the result of significant warming trends found in climate indices analyses.

The influence of climate variables on dengue in Singapore.

PubMed

Pinto, Edna; Coelho, Micheline; Oliver, Leuda; Massad, Eduardo

2011-12-01

In this work we correlated dengue cases with climatic variables for the city of Singapore. This was done through a Poisson Regression Model (PRM) that considers dengue cases as the dependent variable and the climatic variables (rainfall, maximum and minimum temperature and relative humidity) as independent variables. We also used Principal Components Analysis (PCA) to choose the variables that influence in the increase of the number of dengue cases in Singapore, where PC₁ (Principal component 1) is represented by temperature and rainfall and PC₂ (Principal component 2) is represented by relative humidity. We calculated the probability of occurrence of new cases of dengue and the relative risk of occurrence of dengue cases influenced by climatic variable. The months from July to September showed the highest probabilities of the occurrence of new cases of the disease throughout the year. This was based on an analysis of time series of maximum and minimum temperature. An interesting result was that for every 2-10°C of variation of the maximum temperature, there was an average increase of 22.2-184.6% in the number of dengue cases. For the minimum temperature, we observed that for the same variation, there was an average increase of 26.1-230.3% in the number of the dengue cases from April to August. The precipitation and the relative humidity, after analysis of correlation, were discarded in the use of Poisson Regression Model because they did not present good correlation with the dengue cases. Additionally, the relative risk of the occurrence of the cases of the disease under the influence of the variation of temperature was from 1.2-2.8 for maximum temperature and increased from 1.3-3.3 for minimum temperature. Therefore, the variable temperature (maximum and minimum) was the best predictor for the increased number of dengue cases in Singapore.

Maximum Temperature Detection System for Integrated Circuits

NASA Astrophysics Data System (ADS)

Frankiewicz, Maciej; Kos, Andrzej

2015-03-01

The paper describes structure and measurement results of the system detecting present maximum temperature on the surface of an integrated circuit. The system consists of the set of proportional to absolute temperature sensors, temperature processing path and a digital part designed in VHDL. Analogue parts of the circuit where designed with full-custom technique. The system is a part of temperature-controlled oscillator circuit - a power management system based on dynamic frequency scaling method. The oscillator cooperates with microprocessor dedicated for thermal experiments. The whole system is implemented in UMC CMOS 0.18 μm (1.8 V) technology.

Temperature effects on gallium arsenide 63Ni betavoltaic cell.

PubMed

Butera, S; Lioliou, G; Barnett, A M

2017-07-01

A GaAs 63 Ni radioisotope betavoltaic cell is reported over the temperature range 70°C to -20°C. The temperature effects on the key cell parameters were investigated. The saturation current decreased with decreased temperature; whilst the open circuit voltage, the short circuit current, the maximum power and the internal conversion efficiency values decreased with increased temperature. A maximum output power and an internal conversion efficiency of 1.8pW (corresponding to 0.3μW/Ci) and 7% were observed at -20°C, respectively. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Global characteristics in the diurnal variations of the thermospheric temperature and composition

NASA Technical Reports Server (NTRS)

Mayr, H. G.; Hedin, A. E.; Reber, C. A.; Carignan, G. R.

1973-01-01

Global characteristics in the diurnal components of OGO-6 neutral mass spectrometer measurements near 450 km are discussed qualitatively as well as quantitatively on the basis of a theoretical model. Observations and conclusion are summarized: (1) During equinox the temperature maximum occurs after 1600 LT at the equator and shifts toward 1500 LT at the poles, while the oxygen concentration at 450 km peaks about one hour earlier. (2) There is general agreement between the magnitudes and phases of the diurnal, semidiurnal and terdiuranal temperature components at 450 km from theory as well as OGO-6 and radar backscatter measurements. (3) The maximum in the diurnal variation of He is observed near 1030 LT consistent with theoretical results which further emphasize the importance of dynamics and diffusion. (4) During solstice conditions the diurnal temperature maximum shifts toward later local times, in substantial agreement with radar temperature measurements. (5) the temperature-oxygen density phase difference at 450 km is observed to decrease with latitude from the winter toward the summer hemisphere, where oxygen may even peak after the temperature at high latitudes.

[Indoor simulation on dew formation on plant leaves].

PubMed

Gao, Zhi-Yong; Wang, You-Ke; Wei, Xin-Guang; Liu, Shou-Yang; He, Zi-Li; Zhou, Yu-Hong

2014-03-01

Dew forming on plant leaves through water condensation plays a significant ecological role in arid and semi-arid areas as an ignorable fraction of water resources. In this study, an artificial intelligent climate chamber and an automatic temperature-control system for leaves were implemented to regulate the ambient temperature, the leaf surface temperature and the leaf inclination for dew formation. The impact of leaf inclination, ambient temperature and dew point-leaf temperature depression on the rate and quantity of dew accumulation on leaf surface were analyzed. The results indicated that the accumulation rate and the maximum volume of dew on leaves decreased with increasing the leaf inclination while increased with the increment of dew point-leaf temperature depression, ambient temperature and relative humidity. Under the horizontal configuration, dew accumulated linearly on leaf surface over time until the maximum volume (0.80 mm) was reached. However, dew would fall down after reaching the maximum volume when the leaf inclination existed (45 degrees or 90 degrees), significantly slowing down the accumulative rate, and the zigzag pattern for the dynamic of dew accumulation appeared.

Temperature reconstruction and volcanic eruption signal from tree-ring width and maximum latewood density over the past 304 years in the southeastern Tibetan Plateau.

PubMed

Li, Mingqi; Huang, Lei; Yin, Zhi-Yong; Shao, Xuemei

2017-11-01

This study presents a 304-year mean July-October maximum temperature reconstruction for the southeastern Tibetan Plateau based on both tree-ring width and maximum latewood density data. The reconstruction explained 58% of the variance in July-October maximum temperature during the calibration period (1958-2005). On the decadal scale, we identified two prominent cold periods during AD 1801-1833 and 1961-2003 and two prominent warm periods during AD 1730-1800 and 1928-1960, which are consistent with other reconstructions from the nearby region. Based on the reconstructed temperature series and volcanic eruption chronology, we found that most extreme cold years were in good agreement with major volcanic eruptions, such as 1816 after the Tambora eruption in 1815. Also, clusters of volcanic eruptions probably made the 1810s the coldest decade in the past 300 years. Our results indicated that fingerprints of major volcanic eruptions can be found in the reconstructed temperature records, while the responses of regional climate to these eruption events varied in space and time in the southeastern Tibetan Plateau.

Effects of temperature and light on photosynthesis of dominant species of a northern hardwood forest. [Populus grandidentata, Quercus rubra, Betula papyrifera

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jurik, T.W.; Weber, J.A.; Gates, D.M.

1988-06-01

The response of CO{sub 2} exchange rate (CER) to temperature and light was determined for 14 dominant plant species of a northern deciduous hardwood forest in northern lower Michigan. Leaves at the top of the canopy had temperature optima near 25 C for CER, whereas leaves in the understory had optima near 20 C. There was no change in optimum temperature over the growing season, and overall shapes of response curves were similar among species. The lack of change in temperature optima may be a result of little change in growing conditions rather than a lack of ability to acclimatize.more » Nine of 11 species in the understory had no significant differences in light-saturated, maximum CERs, whereas at the top of the canopy Populus grandidentata had a higher maximum CER than Quercus rubra and Betula papyrifera. The species in the understory also differed little in light-saturation points for CER. Species at the top of the canopy had higher values for maximum CER, light-saturation point for CER, and maximum conductance than did species in the understory.« less

Influence of nitromethane concentration on ignition energy and explosion parameters in gaseous nitromethane/air mixtures.

PubMed

Zhang, Qi; Li, Wei; Lin, Da-Chao; He, Ning; Duan, Yun

2011-01-30

The aim of this paper is to provide new experimental data of the minimum ignition energy (MIE) of gaseous nitromethane/air mixtures to discuss the explosion pressure and the flame temperature as a function of nitromethane concentration. Observations on the influence of nitromethane concentration on combustion pressure and temperature through the pressure and temperature measure system show that peak temperature (the peak of combustion temperature wave) is always behind peak pressure (the peak of the combustion pressure wave) in arrival time, the peak combustion pressure of nitromethane increases in the range of its volume fraction 10-40% as the concentration of nitromethane increases, and it slightly decreases in the range of 40-50%. The maximum peak pressure is equal to 0.94 MPa and the minimum peak pressure 0.58 MPa. Somewhat similar to the peak pressure, the peak combustion temperature increases with the volume fraction of nitromethane in the range of 10-40%, and slightly decreases in 40-50%. The maximum peak temperature is 1340 °C and the minimum 860 °C. The combustion temperature rise rate increases with the concentration of nitromethane in 10-30%, while decreases in 30-50% and its maximum value of combustion temperature rise rate in 10-50% is 4200 °C/s at the volume fraction of 30%. Influence of the concentration of nitromethane on the combustion pressure rise rate is relatively complicated, and the maximum value of rise rate of combustion pressure wave in 10-50% is 11 MPa/s at the concentration 20%. Copyright © 2010 Elsevier B.V. All rights reserved.

Rice yields in tropical/subtropical Asia exhibit large but opposing sensitivities to minimum and maximum temperatures

PubMed Central

Welch, Jarrod R.; Vincent, Jeffrey R.; Auffhammer, Maximilian; Moya, Piedad F.; Dobermann, Achim; Dawe, David

2010-01-01

Data from farmer-managed fields have not been used previously to disentangle the impacts of daily minimum and maximum temperatures and solar radiation on rice yields in tropical/subtropical Asia. We used a multiple regression model to analyze data from 227 intensively managed irrigated rice farms in six important rice-producing countries. The farm-level detail, observed over multiple growing seasons, enabled us to construct farm-specific weather variables, control for unobserved factors that either were unique to each farm but did not vary over time or were common to all farms at a given site but varied by season and year, and obtain more precise estimates by including farm- and site-specific economic variables. Temperature and radiation had statistically significant impacts during both the vegetative and ripening phases of the rice plant. Higher minimum temperature reduced yield, whereas higher maximum temperature raised it; radiation impact varied by growth phase. Combined, these effects imply that yield at most sites would have grown more rapidly during the high-yielding season but less rapidly during the low-yielding season if observed temperature and radiation trends at the end of the 20th century had not occurred, with temperature trends being more influential. Looking ahead, they imply a net negative impact on yield from moderate warming in coming decades. Beyond that, the impact would likely become more negative, because prior research indicates that the impact of maximum temperature becomes negative at higher levels. Diurnal temperature variation must be considered when investigating the impacts of climate change on irrigated rice in Asia. PMID:20696908

The costs of keeping cool in a warming world: implications of high temperatures for foraging, thermoregulation and body condition of an arid-zone bird.

PubMed

du Plessis, Katherine L; Martin, Rowan O; Hockey, Philip A R; Cunningham, Susan J; Ridley, Amanda R

2012-10-01

Recent mass mortalities of bats, birds and even humans highlight the substantial threats that rising global temperatures pose for endotherms. Although less dramatic, sublethal fitness costs of high temperatures may be considerable and result in changing population demographics. Endothermic animals exposed to high environmental temperatures can adjust their behaviour (e.g. reducing activity) or physiology (e.g. elevating rates of evaporative water loss) to maintain body temperatures within tolerable limits. The fitness consequences of these adjustments, in terms of the ability to balance water and energy budgets and therefore maintain body condition, are poorly known. We investigated the effects of daily maximum temperature on foraging and thermoregulatory behaviour as well as maintenance of body condition in a wild, habituated population of Southern Pied Babblers Turdoides bicolor. These birds inhabit a hot, arid area of southern Africa where they commonly experience environmental temperatures exceeding optimal body temperatures. Repeated measurements of individual behaviour and body mass were taken across days varying in maximum air temperature. Contrary to expectations, foraging effort was unaffected by daily maximum temperature. Foraging efficiency, however, was lower on hotter days and this was reflected in a drop in body mass on hotter days. When maximum air temperatures exceeded 35.5 °C, individuals no longer gained sufficient weight to counter typical overnight weight loss. This reduction in foraging efficiency is likely driven, in part, by a trade-off with the need to engage in heat-dissipation behaviours. When we controlled for temperature, individuals that actively dissipated heat while continuing to forage experienced a dramatic decrease in their foraging efficiency. This study demonstrates the value of investigations of temperature-dependent behaviour in the context of impacts on body condition, and suggests that increasingly high temperatures will have negative implications for the fitness of these arid-zone birds. © 2012 Blackwell Publishing Ltd.

Radiation-induced polymerization of glass-forming systems. IV. Effect of the homogeneity of polymerization phase and polymer concentration on temperature dependence of initial polymerization rate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kaetsu, I.; Ito, A.; Hayashi, K.

1973-06-01

The effect of homogeneity of polymerization phase and monomer concentration on the temperature dependence of initial polymerization rate was studied in the radiation-induced radical polymerization of binary systems consisting of glass-forming monomer and solvent. In the polymerization of a completely homogeneous system such as HEMA-propylene glycol, a maximum and a minimum in polymerization rates as a function of temperature, characteristic of the polymerization in glass-forming systems, were observed for all monomer concentrations. However, in the heterogeneous polymerization systems such as HEMA-triacetin and HEMAisoamyl acetate, maximum and minimum rates were observed in monomer-rich compositions but not at low monomer concentrations. Furthermore,more » in the HEMA-dioctyl phthalate polymerization system, which is extremely heterogeneous, no maximum and minimum rates were observed at any monomer concentration. The effect of conversion on the temperature dependence of polymerization rate in homogeneous bulk polymerization of HEMA and GMA was investigated. Maximum and minimum rates were observed clearly in conversions less than 10% in the case of HEMA and less than 50% in the case of GMA, but the maximum and minimum changed to a mere inflection in the curve at higher conversions. A similar effect of polymer concentration on the temperature dependence of polymerization rate in the GMA-poly(methyl methacrylate) system was also observed. It is deduced that the change in temperature dependence of polymerization rate is attributed to the decrease in contribution of mutual termination reaction of growing chain radicals to the polymerization rate. (auth)« less

Effect of thermal barrier coatings on the performance of steam and water-cooled gas turbine/steam turbine combined cycle system

NASA Technical Reports Server (NTRS)

Nainiger, J. J.

1978-01-01

An analytical study was made of the performance of air, steam, and water-cooled gas-turbine/steam turbine combined-cycle systems with and without thermal-barrier coatings. For steam cooling, thermal barrier coatings permit an increase in the turbine inlet temperature from 1205 C (2200 F), resulting in an efficiency improvement of 1.9 percentage points. The maximum specific power improvement with thermal barriers is 32.4 percent, when the turbine inlet temperature is increased from 1425 C (2600 F) to 1675 C (3050 F) and the airfoil temperature is kept the same. For water cooling, the maximum efficiency improvement is 2.2 percentage points at a turbine inlet temperature of 1683 C (3062 F) and the maximum specific power improvement is 36.6 percent by increasing the turbine inlet temperature from 1425 C (2600 F) to 1730 C (3150 F) and keeping the airfoil temperatures the same. These improvements are greater than that obtained with combined cycles using air cooling at a turbine inlet temperature of 1205 C (2200 F). The large temperature differences across the thermal barriers at these high temperatures, however, indicate that thermal stresses may present obstacles to the use of coatings at high turbine inlet temperatures.

An Observational and Analytical Study of Marginal Ice Zone Atmospheric Jets

DTIC Science & Technology

2016-12-01

layer or in the capping temperature inversion just above. The three strongest jets had maximum wind speeds at elevations near 350 m to 400 m...geostrophic wind due to horizontal temperature changes in the atmospheric boundary layer and capping inversion . The jets were detected using...temperature inversion just above. The three strongest jets had maximum wind speeds at elevations near 350 m to 400 m elevation; one of these jets had a

Vegetation greenness impacts on maximum and minimum temperatures in northeast Colorado

USGS Publications Warehouse

Hanamean, J. R.; Pielke, R.A.; Castro, C. L.; Ojima, D.S.; Reed, Bradley C.; Gao, Z.

2003-01-01

The impact of vegetation on the microclimate has not been adequately considered in the analysis of temperature forecasting and modelling. To fill part of this gap, the following study was undertaken.A daily 850–700 mb layer mean temperature, computed from the National Center for Environmental Prediction-National Center for Atmospheric Research (NCEP-NCAR) reanalysis, and satellite-derived greenness values, as defined by NDVI (Normalised Difference Vegetation Index), were correlated with surface maximum and minimum temperatures at six sites in northeast Colorado for the years 1989–98. The NDVI values, representing landscape greenness, act as a proxy for latent heat partitioning via transpiration. These sites encompass a wide array of environments, from irrigated-urban to short-grass prairie. The explained variance (r2 value) of surface maximum and minimum temperature by only the 850–700 mb layer mean temperature was subtracted from the corresponding explained variance by the 850–700 mb layer mean temperature and NDVI values. The subtraction shows that by including NDVI values in the analysis, the r2 values, and thus the degree of explanation of the surface temperatures, increase by a mean of 6% for the maxima and 8% for the minima over the period March–October. At most sites, there is a seasonal dependence in the explained variance of the maximum temperatures because of the seasonal cycle of plant growth and senescence. Between individual sites, the highest increase in explained variance occurred at the site with the least amount of anthropogenic influence. This work suggests the vegetation state needs to be included as a factor in surface temperature forecasting, numerical modeling, and climate change assessments.

Versatile Measurement Techniques to Validate Analytical Structural Mechanical Models

DTIC Science & Technology

2007-03-01

temperature is about 33 C. 109 34 For flight 4P temperature and strain data versus flight time is presented. Also a scatter plot of strain for gage 2...versus temperature is shown. As shown in the chart the maximum strain was about 91 microstrain during flight 4P . The maximum temperature is about 87...some more data will be taken on some tests of steel blocks for VASM. 153 33 References • SBIR Topic AF# SD01-CBM04 • LUNA Draft Marketing Manual • Luna

The Effects of Global Warming on Temperature and Precipitation Trends in Northeast America

NASA Astrophysics Data System (ADS)

Francis, F.

2013-12-01

The objective of this paper is to discuss the analysis of results in temperature and precipitation (rainfall) data and how they are affected by the theory of global warming in Northeast America. The topic was chosen because it will show the trends in temperature and precipitation and their relations to global warming. Data was collected from The Global Historical Climatology Network (GHCN). The data range from years of 1973 to 2012. We were able to calculate the yearly and monthly regress to estimate the relationship of variables found in the individual sources. With the use of specially designed software, analysis and manual calculations we are able to give a visualization of these trends in precipitation and temperature and to question if these trends are due to the theory of global warming. With the Calculation of the trends in slope we were able to interpret the changes in minimum and maximum temperature and precipitation. Precipitation had a 9.5 % increase over the past forty years, while maximum temperature increased 1.9 %, a greater increase is seen in minimum temperature of 3.3 % was calculated over the years. The trends in precipitation, maximum and minimum temperature is statistically significant at a 95% level.

Emittance Theory for Cylindrical Fiber Selective Emitter

NASA Technical Reports Server (NTRS)

Chubb, Donald L.

1998-01-01

A fibrous rare earth selective emitter is approximated as an infinitely long cylinder. The spectral emittance, epsilon(lambda), is obtained by solving the radiative transfer equations with appropriate boundary conditions and uniform temperature. For optical depths, Kappa(R) = alpha(lambda)R, where alpha(lambda) is the extinction coefficient and R is the cylinder radius, greater than 1 the spectral emittance is nearly at its maximum value. There is an optimum cylinder radius, R(opt), for maximum emitter efficiency, eta(E). Values for R(opt) are strongly dependent on the number of emission bands of the material. The optimum radius decreases slowly with increasing emitter temperature, while the maximum efficiency and useful radiated power increase rapidly with increasing temperature.

A first-principles model for orificed hollow cathode operation

NASA Technical Reports Server (NTRS)

Salhi, A.; Turchi, P. J.

1992-01-01

A theoretical model describing orificed hollow cathode discharge is presented. The approach adopted is based on a purely analytical formulation founded on first principles. The present model predicts the emission surface temperature and plasma properties such as electron temperature, number densities and plasma potential. In general, good agreements between theory and experiment are obtained. Comparison of the results with the available related experimental data shows a maximum difference of 10 percent in emission surface temperature, 20 percent in electron temperature and 35 percent in plasma potential. In case of the variation of the electron number density with the discharge current a maximum discrepancy of 36 percent is obtained. However, in the case of the variation with the cathode internal pressure, the predicted electron number density is higher than the experimental data by a maximum factor of 2.

Effects of pH and temperature on growth and glycerol production kinetics of two indigenous wine strains of Saccharomyces cerevisiae from Turkey

PubMed Central

Yalcin, Seda Karasu; Yesim Ozbas, Z.

2008-01-01

The study was performed in a batch system in order to determine the effects of pH and temperature on growth and glycerol production kinetics of two indigenous wine yeast strains Saccharomyces cerevisiae Kalecik 1 and Narince 3. The highest values of dry mass and specific growth rate were obtained at pH 4.00 for both of the strains. Maximum specific glycerol production rates were obtained at pH 5.92 and 6.27 for the strains Kalecik 1 and Narince 3, respectively. Kalecik 1 strain produced maximum 8.8 gL−1 of glycerol at pH 6.46. Maximum glycerol concentration obtained by the strain Narince 3 was 9.1 gL−1 at pH 6.48. Both yeasts reached maximum specific growth rate at 30°C. Optimum temperature range for glycerol production was determined as 25-30°C for the strain Kalecik 1. The strain Narince 3 reached maximum specific glycerol production rate at 30°C. Maximum glycerol concentrations at 30°C were obtained as 8.5 and 7.6 gL−1 for Kalecik 1 and Narince 3, respectively. PMID:24031225

40 CFR 86.1233-96 - Diurnal emission test.

Code of Federal Regulations, 2010 CFR

2010-07-01

... the underbody temperature sensor shall follow the profile with a maximum deviation of 3 °F at any time... temperature sensors shall follow the profile with a maximum deviation of 5 °F at any time. (2) Ambient... deionized water shall be placed in the methanol sampling system (methanol-fueled vehicles only). (3) Turn...

40 CFR 86.133-96 - Diurnal emission test.

Code of Federal Regulations, 2010 CFR

2010-07-01

... the underbody temperature sensor shall follow the profile with a maximum deviation of 3 °F at any time... temperature sensors shall follow the profile with a maximum deviation of 5 °F at any time. (2) Ambient... deionized water shall be placed in the methanol sampling system (methanol-fueled vehicles only). (3) Turn...

Variation in the sensitivity of organismal body temperature to climate change over local and geographic scales.

PubMed

Gilman, Sarah E; Wethey, David S; Helmuth, Brian

2006-06-20

Global climate change is expected to have broad ecological consequences for species and communities. Attempts to forecast these consequences usually assume that changes in air or water temperature will translate into equivalent changes in a species' organismal body temperature. This simple change is unlikely because an organism's body temperature is determined by a complex series of interactions between the organism and its environment. Using a biophysical model, validated with 5 years of field observations, we examined the relationship between environmental temperature change and body temperature of the intertidal mussel Mytilus californianus over 1,600 km of its geographic distribution. We found that at all locations examined simulated changes in air or water temperature always produced less than equivalent changes in the daily maximum mussel body temperature. Moreover, the magnitude of body temperature change was highly variable, both within and among locations. A simulated 1 degrees C increase in air or water temperature raised the maximum monthly average of daily body temperature maxima by 0.07-0.92 degrees C, depending on the geographic location, vertical position, and temperature variable. We combined these sensitivities with predicted climate change for 2100 and calculated increases in monthly average maximum body temperature of 0.97-4.12 degrees C, depending on location and climate change scenario. Thus geographic variation in body temperature sensitivity can modulate species' experiences of climate change and must be considered when predicting the biological consequences of climate change.

Modeling water and heat balance components of large territory for vegetation season using information from polar-orbital and geostationary meteorological satellites

NASA Astrophysics Data System (ADS)

Muzylev, Eugene; Startseva, Zoya; Uspensky, Alexander; Volkova, Elena; Kukharsky, Alexander; Uspensky, Sergey

2015-04-01

To date, physical-mathematical modeling processes of land surface-atmosphere interaction is considered to be the most appropriate tool for obtaining reliable estimates of water and heat balance components of large territories. The model of these processes (Land Surface Model, LSM) developed for vegetation period is destined for simulating soil water content W, evapotranspiration Ev, vertical latent LE and heat fluxes from land surface as well as vertically distributed soil temperature and moisture, soil surface Tg and foliage Tf temperatures, and land surface skin temperature (LST) Ts. The model is suitable for utilizing remote sensing data on land surface and meteorological conditions. In the study these data have been obtained from measurements by scanning radiometers AVHRR/NOAA, MODIS/EOS Terra and Aqua, SEVIRI/geostationary satellites Meteosat-9, -10 (MSG-2, -3). The heterogeneity of the land surface and meteorological conditions has been taken into account in the model by using soil and vegetation characteristics as parameters and meteorological characteristics as input variables. Values of these characteristics have been determined from ground observations and remote sensing information. So, AVHRR data have been used to build the estimates of effective land surface temperature (LST) Ts.eff and emissivity E, vegetation-air temperature (temperature at the vegetation level) Ta, normalized vegetation index NDVI, vegetation cover fraction B, the leaf area index LAI, and precipitation. From MODIS data the values of LST Tls, Å, NDVI, LAI have been derived. From SEVIRI data there have been retrieved Tls, E, Ta, NDVI, LAI and precipitation. All named retrievals covered the vast territory of the part of the agricultural Central Black Earth Region located in the steppe-forest zone of European Russia. This territory with coordinates 49°30'-54°N, 31°-43°E and a total area of 227,300 km2 has been chosen for investigation. It has been carried out for years 2009-2013 vegetation seasons. To provide the retrieval of Ts.eff, E, Ta, NDVI, B, and LAI the previously developed technologies of AVHRR data processing have been refined and adapted to the region of interest. The updated linear regression estimators for Ts.eff and Tà have been built using representative training samples compiled for above vegetation seasons. The updated software package has been applied for AVHRR data processing to generate estimates of named values. To verify the accuracy of these estimates the error statistics of Ts.eff and Ta derivation has been investigated for various days of named seasons using comparison with in-situ ground-based measurements. On the base of special technology and Internet resources the remote sensing products Tls, E, NDVI, LAI derived from MODIS data and covering the study area have been extracted from LP DAAC web-site for the same vegetation seasons. The reliability of the MODIS-derived Tls estimates has been confirmed via comparison with analogous and collocated ground-, AVHRR-, and SEVIRI-based ones. The prepared remote sensing dataset has also included the SEVIRI-derived estimates of Tls, E, NDVI, Ta at daylight and night-time and daily estimates of LAI. The Tls estimates has been built utilizing the method and technology developed for the retrieval of Tls and E from 15 minutes time interval SEVIRI data in IR channels 10.8 and 12.0 µm (classified as 100% cloud-free and covering the area of interest) at three successive times without accurate a priori knowledge of E. Comparison of the SEVIRI-based Tls retrievals with independent collocated Tls estimates generated at the Land Surface Analysis Satellite Applications Facility (LSA SAF, Lisbon, Portugal) has given daily- or monthly-averaged values of RMS deviation in the range of 2°C for various dates and months during the mentioned vegetation seasons which is quite acceptable result. The reliability of the SEVIRI-based Tls estimates for the study area has been also confirmed by comparing with AVHRR- and MODIS-derived LST estimates for the same seasons. The SEVIRI-derived values of Ta considered as the temperature of the vegetation cover has been obtained using Tls estimates and a previously found multiple linear regression relationship between Tls and Ta formulated accounting for solar zenith angle and land elevation. A comparison with ground-based collocated Ta observations has given RMS errors of 2.5°C and lower. It can be treated as a proof of the proposed technique's functionality. SEVIRI-derived LAI estimates have been retrieved at LSA SAF from measurements by this sensor in channels 0.6, 0.8, and 1.6 μm under cloud-free conditions at that when using data in the channel 1.6 μm the accuracy of these estimates has increased. In the study the AVHRR- and SEVIRI-derived estimates of daily and monthly precipitation sums for the territory under investigation for the years 2009 - 2013 vegetation seasons have been also used. These estimates have been obtained by the improved integrated Multi Threshold Method (MTM) providing detection and identification of cloud types around the clock throughout the year as well as identification of precipitation zones and determination of instantaneous precipitation maximum intensity within the pixel using the measurement data in different channels of named sensors as predictors. Validation of the MTM has been performed by comparing the daily and monthly precipitation sums with appropriate values resulted from ground-based observations at the meteorological stations of the region. The probability of detecting precipitation zones from satellite data corresponding to the actual ones has been amounted to 70-80%. AVHRR- and SEVIRI-derived daily and monthly precipitation sums have been in reasonable agreement with each other and with results of ground-based observations although they are smoother than the last values. Discrepancies have been noted only for local maxima for which satellite-based estimates of precipitation have been much less than ground-based ones. It may be due to the different spatial scales of areal satellite-derived and point ground-based estimates. To utilize satellite-derived vegetation and meteorological characteristics in the model the special procedures have been developed including: - replacement of ground-based LAI and B estimates used as model parameters by their satellite-derived estimates from AVHRR, MODIS and SEVIRI data. Correctness of such replacement has been confirmed by comparing the time behavior of LAI over the period of vegetation as well as modeled and measured values of evapotranspiration Ev and soil moisture content W; - entering AVHRR-, MODIS- and SEVIRI-derived estimates of Ts.eff Tls, and Ta into the model as input variables instead of ground-measured values with verification of adequacy of model operation under such a change through comparison of the calculated and measured values of W and Ev; - inputing satellite-derived estimates of precipitation during vegetation period retrieved from AVHRR and SEVIRI data using the MTM into the model as input variables. When developing given procedure algorithms and programs have been created to transit from assessment of the rainfall intensity to evaluation of its daily values. The implementation of such a transition requires controlling correctness of the estimates built at each time step. This control includes comparison of areal distributions of three-hour, daily and monthly precipitation amounts obtained from satellite data and calculated by interpolation of standard network observation data; - taking into account spatial heterogeneity of fields of satellite AVHRR-, MODIS- and SEVIRI-derived estimates of LAI, B, LST and precipitation. This has involved the development of algorithms and software for entering the values of all named characteristics into the model in each computational grid node. Values of evapotranspiration E, soil water content W, vertical latent and sensible heat fluxes and other water and heat balance components as well as land surface temperature and moisture area-distributed over the territory of interest have been resulted from the model calculations for the years 2009-2013 vegetation seasons. These calculations have been carried out utilizing satellite-derived estimates of the vegetation characteristics, LST and precipitation. E and W calculation errors have not exceeded the standard values.

Igniter adapter-to-igniter chamber deflection test

NASA Technical Reports Server (NTRS)

Cook, M.

1990-01-01

Testing was performed to determine the maximum RSRM igniter adapter-to-igniter chamber joint deflection at the crown of the inner joint primary seal. The deflection data was gathered to support igniter inner joint gasket resiliency predictions which led to launch commit criteria temperature determinations. The proximity (deflection) gage holes for the first test (Test No. 1) were incorrectly located; therefore, the test was declared a non-test. Prior to Test No. 2, test article configuration was modified with the correct proximity gage locations. Deflection data were successfully acquired during Test No. 2. However, the proximity gage deflection measurements were adversely affected by temperature increases. Deflections measured after the temperature rise at the proximity gages were considered unreliable. An analysis was performed to predict the maximum deflections based on the reliable data measured before the detectable temperature rise. Deflections to the primary seal crown location were adjusted to correspond to the time of maximum expected operating pressure (2,159 psi) to account for proximity gage bias, and to account for maximum attach and special bolt relaxation. The maximum joint deflection for the igniter inner joint at the crown of the primary seal, accounting for all significant correction factors, was 0.0031 in. (3.1 mil). Since the predicted (0.003 in.) and tested maximum deflection values were sufficiently close, the launch commit criteria was not changed as a result of this test. Data from this test should be used to determine if the igniter inner joint gasket seals are capable of maintaining sealing capability at a joint displacement of (1.4) x (0.0031 in.) = 0.00434 inches. Additional testing should be performed to increase the database on igniter deflections and address launch commit criteria temperatures.

3D thermal model of laser surface glazing for H13 tool steel

NASA Astrophysics Data System (ADS)

Kabir, I. R.; Yin, D.; Naher, S.

2017-10-01

In this work a three dimensional (3D) finite element model of laser surface glazing (LSG) process has been developed. The purpose of the 3D thermal model of LSG was to achieve maximum accuracy towards the predicted outcome for optimizing the process. A cylindrical geometry of 10mm diameter and 1mm length was used in ANSYS 15 software. Temperature distribution, depth of modified zone and cooling rates were analysed from the thermal model. Parametric study was carried out varying the laser power from 200W-300W with constant beam diameter and residence time which were 0.2mm and 0.15ms respectively. The maximum surface temperature 2554°K was obtained for power 300W and minimum surface temperature 1668°K for power 200W. Heating and cooling rates increased with increasing laser power. The depth of the laser modified zone attained for 300W power was 37.5µm and for 200W power was 30µm. No molten zone was observed at 200W power. Maximum surface temperatures obtained from 3D model increased 4% than 2D model presented in author's previous work. In order to verify simulation results an analytical solution of temperature distribution for laser surface modification was used. The surface temperature after heating was calculated for similar laser parameters which is 1689°K. The difference in maximum surface temperature is around 20.7°K between analytical and numerical analysis of LSG for power 200W.

Nonlogarithmic magnetization relaxation at the initial time intervals and magnetic field dependence of the flux creep rate in Bi2Sr2Ca(sub I)Cu2Ox single crystals

NASA Technical Reports Server (NTRS)

Moshchalcov, V. V.; Zhukov, A. A.; Kuznetzov, V. D.; Metlushko, V. V.; Leonyuk, L. I.

1990-01-01

At the initial time intervals, preceding the thermally activated flux creep regime, fast nonlogarithmic relaxation is found. The fully magnetic moment Pm(t) relaxation curve is shown. The magnetic measurements were made using SQUID-magnetometer. Two different relaxation regimes exist. The nonlogarithmic relaxation for the initial time intervals may be related to the viscous Abrikosov vortices flow with j is greater than j(sub c) for high enough temperature T and magnetic field induction B. This assumption correlates with Pm(t) measurements. The characteristic time t(sub O) separating two different relaxation regimes decreases as temperature and magnetic field are lowered. The logarithmic magnetization relaxation curves Pm(t) for fixed temperature and different external magnetic field inductions B are given. The relaxation rate dependence on magnetic field, R(B) = dPm(B, T sub O)/d(1nt) has a sharp maximum which is similar to that found for R(T) temperature dependences. The maximum shifts to lower fields as temperature goes up. The observed sharp maximum is related to a topological transition in shielding critical current distribution and, consequently, in Abrikosov vortices density. The nonlogarithmic magnetization relaxation for the initial time intervals is found. This fast relaxation has almost an exponentional character. The sharp relaxation rate R(B) maximum is observed. This maximum corresponds to a topological transition in Abrikosov vortices distribution.

Thermal management optimization of an air-cooled Li-ion battery module using pin-fin heat sinks for hybrid electric vehicles

NASA Astrophysics Data System (ADS)

Mohammadian, Shahabeddin K.; Zhang, Yuwen

2015-01-01

Three dimensional transient thermal analysis of an air-cooled module that contains prismatic Li-ion cells next to a special kind of aluminum pin fin heat sink whose heights of pin fins increase linearly through the width of the channel in air flow direction was studied for thermal management of Lithium-ion battery pack. The effects of pin fins arrangements, discharge rates, inlet air flow velocities, and inlet air temperatures on the battery were investigated. The results showed that despite of heat sinks with uniform pin fin heights that increase the standard deviation of the temperature field, using this kind of pin fin heat sink compare to the heat sink without pin fins not only decreases the bulk temperature inside the battery, but also decreases the standard deviation of the temperature field inside the battery as well. Increasing the inlet air temperature leads to decreasing the standard deviation of the temperature field while increases the maximum temperature of the battery. Furthermore, increasing the inlet air velocity first increases the standard deviation of the temperature field till reaches to the maximum point, and after that decreases. Also, increasing the inlet air velocity leads to decrease in the maximum temperature of the battery.

Global patterns of declining temperature variability from the Last Glacial Maximum to the Holocene

NASA Astrophysics Data System (ADS)

Rehfeld, Kira; Münch, Thomas; Ho, Sze Ling; Laepple, Thomas

2018-02-01

Changes in climate variability are as important for society to address as are changes in mean climate. Contrasting temperature variability during the Last Glacial Maximum and the Holocene can provide insights into the relationship between the mean state of the climate and its variability. However, although glacial-interglacial changes in variability have been quantified for Greenland, a global view remains elusive. Here we use a network of marine and terrestrial temperature proxies to show that temperature variability decreased globally by a factor of four as the climate warmed by 3-8 degrees Celsius from the Last Glacial Maximum (around 21,000 years ago) to the Holocene epoch (the past 11,500 years). This decrease had a clear zonal pattern, with little change in the tropics (by a factor of only 1.6-2.8) and greater change in the mid-latitudes of both hemispheres (by a factor of 3.3-14). By contrast, Greenland ice-core records show a reduction in temperature variability by a factor of 73, suggesting influences beyond local temperature or a decoupling of atmospheric and global surface temperature variability for Greenland. The overall pattern of reduced variability can be explained by changes in the meridional temperature gradient, a mechanism that points to further decreases in temperature variability in a warmer future.

Association between summer temperature and body weight in Japanese adolescents and children: An ecological analysis.

PubMed

Yokoya, Masana; Higuchi, Yukito

2016-11-01

Several experimental studies reported evidence of a negative energy balance at higher temperatures. However, corresponding weight loss has not been noted in clinical practice. This study investigated the geographical association between outdoor temperature and body weight in Japanese adolescents and children. An ecological analysis was conducted using prefecture-level data on the mean body weight of Japanese adolescents and children over a 25-year period and Japanese mesh (regional) climatic data on the mean annual temperature, mean daily maximum temperature in August, and mean daily minimum temperature in January were also analyzed. Correlation analysis uncovered a stronger association between weight and the mean daily maximum temperature in August than with other climatic variables. Moreover, multiple regression analysis indicated that height and the mean daily maximum temperature in August were statistically significant predictors of weight. This suggests that geographical differences in weight in Japanese adolescents and children can be explained by the complementary relationship between height-associated weight gain and weight loss caused by summer heat. Summer temperatures may reduce the proportion of children who are overweight and contribute to geographical differences in body weight in Japanese adolescents and children. Am. J. Hum. Biol. 28:789-795, 2016. © 2016Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Global patterns of declining temperature variability from the Last Glacial Maximum to the Holocene.

PubMed

Rehfeld, Kira; Münch, Thomas; Ho, Sze Ling; Laepple, Thomas

2018-02-15

Changes in climate variability are as important for society to address as are changes in mean climate. Contrasting temperature variability during the Last Glacial Maximum and the Holocene can provide insights into the relationship between the mean state of the climate and its variability. However, although glacial-interglacial changes in variability have been quantified for Greenland, a global view remains elusive. Here we use a network of marine and terrestrial temperature proxies to show that temperature variability decreased globally by a factor of four as the climate warmed by 3-8 degrees Celsius from the Last Glacial Maximum (around 21,000 years ago) to the Holocene epoch (the past 11,500 years). This decrease had a clear zonal pattern, with little change in the tropics (by a factor of only 1.6-2.8) and greater change in the mid-latitudes of both hemispheres (by a factor of 3.3-14). By contrast, Greenland ice-core records show a reduction in temperature variability by a factor of 73, suggesting influences beyond local temperature or a decoupling of atmospheric and global surface temperature variability for Greenland. The overall pattern of reduced variability can be explained by changes in the meridional temperature gradient, a mechanism that points to further decreases in temperature variability in a warmer future.

Climate Change and Simulation of Cardiovascular Disease Mortality: A Case Study of Mashhad, Iran.

PubMed

Baaghideh, Mohammad; Mayvaneh, Fatemeh

2017-03-01

Weather and climate play a significant role in human health. We are accustomed to affects the weather conditions. By increasing or decreasing the environment temperature or change of seasons, some diseases become prevalent or remove. This study investigated the role of temperature in cardiovascular disease mortality of city of Mashhad in the current decade and its simulation in the future decades under conditions of climate change. Cardiovascular disease mortality data and the daily temperatures data were used during (2004-2013) period. First, the correlation between cardiovascular disease mortality and maximum and minimum temperatures were calculated then by using General Circulation Model, Emissions Scenarios, and temperature data were extracted for the next five decades and finally, mortality was simulated. There is a strong positive association between maximum temperature and mortality (r= 0.83, P -value<0.01), also observed a negative and weak but significant association between minimum temperatures and mortality. The results obtained from simulation show increased temperature in the next decades in Mashhad and a 1 °C increase in maximum temperature is associated with a 4.27% (95%CI: 0.91, 7.00) increase in Cardiovascular disease mortality. By increasing temperature and the number of hot days the cardiovascular disease mortality increases and these increases will be intensified in the future decades. Therefore, necessary preventive measures are required to mitigate temperature effects with greater attention to vulnerable group.

Influence of temperature on muscle recruitment and muscle function in vivo.

PubMed

Rome, L C

1990-08-01

Temperature has a large influence on the maximum velocity of shortening (Vmax) and maximum power output of muscle (Q10 = 1.5-3). In some animals, maximum performance and maximum sustainable performance show large temperature sensitivities, because these parameters are dependent solely on mechanical power output of the muscles. The mechanics of locomotion (sarcomere length excursions and muscle-shortening velocities, V) at a given speed, however, are precisely the same at all temperatures. Animals compensate for the diminished power output of their muscles at low temperatures by compressing their recruitment order into a narrower range of locomotor speeds, that is, recruiting more muscle fibers and faster fiber types at a given speed. By examining V/Vmax, I calculate that fish at 10 degrees C must recruit 1.53-fold greater fiber cross section than at 20 degrees C. V/Vmax also appears to be an important design constraint in muscle. It sets the lowest V and the highest V over which a muscle can be used effectively. Because the Vmax of carp slow red muscle has a Q10 of 1.6 between 10 and 20 degrees C, the slow aerobic fibers can be used over a 1.6-fold greater range of swim speeds at the warmer temperature. In some species of fish, Vmax can be increased during thermal acclimation, enabling animals to swim at higher speeds.

The maximum growth rate of life on Earth

NASA Astrophysics Data System (ADS)

Corkrey, Ross; McMeekin, Tom A.; Bowman, John P.; Olley, June; Ratkowsky, David

2018-01-01

Life on Earth spans a range of temperatures and exhibits biological growth rates that are temperature dependent. While the observation that growth rates are temperature dependent is well known, we have recently shown that the statistical distribution of specific growth rates for life on Earth is a function of temperature (Corkrey et al., 2016). The maximum rates of growth of all life have a distinct limit, even when grown under optimal conditions, and which vary predictably with temperature. We term this distribution of growth rates the biokinetic spectrum for temperature (BKST). The BKST possibly arises from a trade-off between catalytic activity and stability of enzymes involved in a rate-limiting Master Reaction System (MRS) within the cell. We develop a method to extrapolate quantile curves for the BKST to obtain the posterior probability of the maximum rate of growth of any form of life on Earth. The maximum rate curve conforms to the observed data except below 0°C and above 100°C where the predicted value may be positively biased. The deviation below 0°C may arise from the bulk properties of water, while the degradation of biomolecules may be important above 100°C. The BKST has potential application in astrobiology by providing an estimate of the maximum possible growth rate attainable by terrestrial life and perhaps life elsewhere. We suggest that the area under the maximum growth rate curve and the peak rate may be useful characteristics in considerations of habitability. The BKST can serve as a diagnostic for unusual life, such as second biogenesis or non-terrestrial life. Since the MRS must have been heavily conserved the BKST may contain evolutionary relics. The BKST can serve as a signature summarizing the nature of life in environments beyond Earth, or to characterize species arising from a second biogenesis on Earth.

Intensification of the meridional temperature gradient in the Great Barrier Reef following the Last Glacial Maximum.

PubMed

Felis, Thomas; McGregor, Helen V; Linsley, Braddock K; Tudhope, Alexander W; Gagan, Michael K; Suzuki, Atsushi; Inoue, Mayuri; Thomas, Alexander L; Esat, Tezer M; Thompson, William G; Tiwari, Manish; Potts, Donald C; Mudelsee, Manfred; Yokoyama, Yusuke; Webster, Jody M

2014-06-17

Tropical south-western Pacific temperatures are of vital importance to the Great Barrier Reef (GBR), but the role of sea surface temperatures (SSTs) in the growth of the GBR since the Last Glacial Maximum remains largely unknown. Here we present records of Sr/Ca and δ(18)O for Last Glacial Maximum and deglacial corals that show a considerably steeper meridional SST gradient than the present day in the central GBR. We find a 1-2 °C larger temperature decrease between 17° and 20°S about 20,000 to 13,000 years ago. The result is best explained by the northward expansion of cooler subtropical waters due to a weakening of the South Pacific gyre and East Australian Current. Our findings indicate that the GBR experienced substantial meridional temperature change during the last deglaciation, and serve to explain anomalous deglacial drying of northeastern Australia. Overall, the GBR developed through significant SST change and may be more resilient than previously thought.

Trends and variability of daily temperature and precipitation extremes during 1960-2012 in the Yangtze River Basin, China

NASA Astrophysics Data System (ADS)

Guan, Yinghui

2017-04-01

The variability of surface air temperature and precipitation extremes has been the focus of attention during the past several decades, and may exert a great influence on the global hydrologic cycle and energy balance through thermal forcing. Using daily minimum (TN), maximum temperature (TX) and precipitation　from 143 meteorological stations in the Yangtze River Basin (YRB), a suite of extreme climate indices recommended by the Expert Team on Climate Change Detection and Indices, which has rarely been applied in this region, were computed and analyzed during 1960-2012. The results show widespread significant changes in all temperature indices associated with warming in the YRB during 1960-2012. On the whole, cold-related indices, i.e., cold nights, cold days, frost days, icing days and cold spell duration index significantly decreased by -3.45, -1.03, -3.04, -0.42 and -1.6 days/decade, respectively. In contrast, warm-related indices such as warm nights, warm days, summer days, tropical nights and warm spell duration index significantly increased by 2.95, 1.71, 2.16, 1.05 and 0.73 days/decade. Minimum TN, maximum TN, minimum TX and maximum TX increased significantly by 0.42, 0.18, 0.19 and 0.14 °C/decade. Because of a faster increase in minimum temperature than maximum temperature, the diurnal temperature range (DTR) exhibited a significant decreasing trend of -0.09 °C/decade for the whole YRB during 1960-2012. Geographically, stations in the eastern Tibet Plateau and northeastern YRB showed stronger trends in almost all temperature indices. Time series analysis indicated that the YRB was dominated by a general cooling trend before the mid-1980s, but a warming trend afterwards. For precipitation, simple daily intensity index, very wet day precipitation, extremely wet day precipitation, extremely heavy precipitation days, maximum 1-day precipitation, maximum 5-day precipitation and maximum consecutive dry days all increased significantly during 1960-2012. In contrast, ≥ 10 mm precipitation days and maximum consecutive wet days decreased significantly, implying that the precipitation processes in YRB were dominated by precipitation events with shorter durations. Geographically, a wetting tendency was observed in the eastern Tibet Plateau and the middle and lower YRB, while the other regions experienced precipitation deficits. The increasing precipitation was mainly due to the intensification of extreme precipitation events and the decreasing precipitation may be attributed to the decrease of ≥ 10 mm precipitation days or moderate precipitation events. In addition, the regional trends were of greater magnitudes in the middle and lower YRB, indicating more frequent extreme precipitation events in these sub-regions.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Wei; Zhang, Xingyi, E-mail: zhangxingyi@lzu.edu.cn; Liu, Cong

We construct a visible instrument to study the mechanical-electro behaviors of high temperature superconducting tape as a function of magnetic field, strain, and temperature. This apparatus is directly cooled by a commercial Gifford-McMahon cryocooler. The minimum temperature of sample can be 8.75 K. A proportion integration differentiation temperature control is used, which is capable of producing continuous variation of specimen temperature from 8.75 K to 300 K with an optional temperature sweep rate. We use an external loading device to stretch the superconducting tape quasi-statically with the maximum tension strain of 20%. A superconducting magnet manufactured by the NbTi strandmore » is applied to provide magnetic field up to 5 T with a homogeneous range of 110 mm. The maximum fluctuation of the magnetic field is less than 1%. We design a kind of superconducting lead composed of YBa2Cu3O7-x coated conductor and beryllium copper alloy (BeCu) to transfer DC to the superconducting sample with the maximum value of 600 A. Most notably, this apparatus allows in situ observation of the electromagnetic property of superconducting tape using the classical magnetic-optical imaging.« less

The Ultrachopper tip: a wound temperature study.

PubMed

Barlow, William R; Pettey, Jeff; Olson, Randall J

2013-12-01

To determine the thermal characteristics of the Ultrachopper and its thermal properties in varied viscosurgical substances. Experimental study. Not applicable. The Ultrachopper (Alcon, Inc) tip with the Infiniti (Alcon, Inc) handpiece was attached to a thermistor and placed in a test chamber filled with either an ophthalmic viscosurgical device (OVD) or balanced salt solution (BSS). The thermistor allowed for continuous monitoring of temperature from baseline and the change that occurred over 60 seconds of continuous run time. Mean maximum temperature in each OVD exceeded 50°C over the first 25 seconds of continuous run time. The mean maximum temperature was statistically significantly higher with all OVDs (p < 0.0001) when compared with BSS. A small but statistically significant difference in mean maximum temperature was shown between Healon 5 (AMO, Inc) and Viscoat (Alcon, Inc) (p < 0.05). The linear increase in temperature was statistically significantly different with all OVDs compared with BSS (p < 0.0001). The thermal properties of the Ultrachopper tip demonstrate a heat-generating capacity that achieves published thresholds for risk for wound burn. Copyright © 2013 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.

Model predictive control of the solid oxide fuel cell stack temperature with models based on experimental data

NASA Astrophysics Data System (ADS)

Pohjoranta, Antti; Halinen, Matias; Pennanen, Jari; Kiviaho, Jari

2015-03-01

Generalized predictive control (GPC) is applied to control the maximum temperature in a solid oxide fuel cell (SOFC) stack and the temperature difference over the stack. GPC is a model predictive control method and the models utilized in this work are ARX-type (autoregressive with extra input), multiple input-multiple output, polynomial models that were identified from experimental data obtained from experiments with a complete SOFC system. The proposed control is evaluated by simulation with various input-output combinations, with and without constraints. A comparison with conventional proportional-integral-derivative (PID) control is also made. It is shown that if only the stack maximum temperature is controlled, a standard PID controller can be used to obtain output performance comparable to that obtained with the significantly more complex model predictive controller. However, in order to control the temperature difference over the stack, both the stack minimum and the maximum temperature need to be controlled and this cannot be done with a single PID controller. In such a case the model predictive controller provides a feasible and effective solution.

Water and Temperature Stresses Impact Canola (Brassica napus L.) Fatty Acid, Protein, and Yield over Nitrogen and Sulfur.

PubMed

Hammac, W Ashley; Maaz, Tai M; Koenig, Richard T; Burke, Ian C; Pan, William L

2017-12-06

Interactive effects of weather and soil nutrient status often control crop productivity. An experiment was conducted to determine effects of nitrogen (N) and sulfur (S) fertilizer rate, soil water, and atmospheric temperature on canola (Brassica napus L.) fatty acid (FA), total oil, protein, and grain yield. Nitrogen and sulfur were assessed in a 4-yr study with two locations, five N rates (0, 45, 90, 135, and 180 kg ha -1 ), and two S rates (0 and 17 kg ha -1 ). Water and temperature were assessed using variability across 12 site-years of dryland canola production. Effects of N and S were inconsistent. Unsaturated FA, oleic acid, grain oil, protein, and theoretical maximum grain yield were highly related to water and temperature variability across the site-years. A nonlinear model identified water and temperature conditions that enabled production of maximum unsaturated FA content, oleic acid content, total oil, protein, and theoretical maximum grain yield. Water and temperature variability played a larger role than soil nutrient status on canola grain constituents and yield.

Effects of fasting on maximum thermogenesis in temperature-acclimated rats

NASA Astrophysics Data System (ADS)

Wang, L. C. H.

1981-09-01

To further investigate the limiting effect of substrates on maximum thermogenesis in acute cold exposure, the present study examined the prevalence of this effect at different thermogenic capabilities consequent to cold- or warm-acclimation. Male Sprague-Dawley rats (n=11) were acclimated to 6, 16 and 26‡C, in succession, their thermogenic capabilities after each acclimation temperature were measured under helium-oxygen (21% oxygen, balance helium) at -10‡C after overnight fasting or feeding. Regardless of feeding conditions, both maximum and total heat production were significantly greater in 6>16>26‡C-acclimated conditions. In the fed state, the total heat production was significantly greater than that in the fasted state at all acclimating temperatures but the maximum thermogenesis was significant greater only in the 6 and 16‡C-acclimated states. The results indicate that the limiting effect of substrates on maximum and total thermogenesis is independent of the magnitude of thermogenic capability, suggesting a substrate-dependent component in restricting the effective expression of existing aerobic metabolic capability even under severe stress.

Comparison of eastern tropical Pacific TEX86 and Globigerinoides ruber Mg/Ca derived sea surface temperatures: Insights from the Holocene and Last Glacial Maximum

NASA Astrophysics Data System (ADS)

Hertzberg, Jennifer E.; Schmidt, Matthew W.; Bianchi, Thomas S.; Smith, Richard W.; Shields, Michael R.; Marcantonio, Franco

2016-01-01

The use of the TEX86 temperature proxy has thus far come to differing results as to whether TEX86 temperatures are representative of surface or subsurface conditions. In addition, although TEX86 temperatures might reflect sea surface temperatures based on core-top (Holocene) values, this relationship might not hold further back in time. Here, we investigate the TEX86 temperature proxy by comparing TEX86 temperatures to Mg/Ca temperatures of multiple species of planktonic foraminifera for two sites in the eastern tropical Pacific (on the Cocos and Carnegie Ridges) across the Holocene and Last Glacial Maximum. Core-top and Holocene TEX86H temperatures at both study regions agree well, within error, with the Mg/Ca temperatures of Globigerinoides ruber, a surface dwelling planktonic foraminifera. However, during the Last Glacial Maximum, TEX86H temperatures are more representative of upper thermocline temperatures, and are offset from G. ruber Mg/Ca temperatures by 5.8 °C and 2.9 °C on the Cocos Ridge and Carnegie Ridge, respectively. This offset between proxies cannot be reconciled by using different TEX86 temperature calibrations, and instead, we suggest that the offset is due to a deeper export depth of GDGTs at the LGM. We also compare the degree of glacial cooling at both sites based on both temperature proxies, and find that TEX86H temperatures greatly overestimate glacial cooling, especially on the Cocos Ridge. This study has important implications for applying the TEX86 paleothermometer in the eastern tropical Pacific.

A visualization instrument to investigate the mechanical-electro properties of high temperature superconducting tapes under multi-fields

NASA Astrophysics Data System (ADS)

Liu, Wei; Zhang, Xingyi; Liu, Cong; Zhang, Wentao; Zhou, Jun; Zhou, YouHe

2016-07-01

We construct a visible instrument to study the mechanical-electro behaviors of high temperature superconducting tape as a function of magnetic field, strain, and temperature. This apparatus is directly cooled by a commercial Gifford-McMahon cryocooler. The minimum temperature of sample can be 8.75 K. A proportion integration differentiation temperature control is used, which is capable of producing continuous variation of specimen temperature from 8.75 K to 300 K with an optional temperature sweep rate. We use an external loading device to stretch the superconducting tape quasi-statically with the maximum tension strain of 20%. A superconducting magnet manufactured by the NbTi strand is applied to provide magnetic field up to 5 T with a homogeneous range of 110 mm. The maximum fluctuation of the magnetic field is less than 1%. We design a kind of superconducting lead composed of YBa2Cu3O7-x coated conductor and beryllium copper alloy (BeCu) to transfer DC to the superconducting sample with the maximum value of 600 A. Most notably, this apparatus allows in situ observation of the electromagnetic property of superconducting tape using the classical magnetic-optical imaging.

A visualization instrument to investigate the mechanical-electro properties of high temperature superconducting tapes under multi-fields.

PubMed

Liu, Wei; Zhang, Xingyi; Liu, Cong; Zhang, Wentao; Zhou, Jun; Zhou, YouHe

2016-07-01

We construct a visible instrument to study the mechanical-electro behaviors of high temperature superconducting tape as a function of magnetic field, strain, and temperature. This apparatus is directly cooled by a commercial Gifford-McMahon cryocooler. The minimum temperature of sample can be 8.75 K. A proportion integration differentiation temperature control is used, which is capable of producing continuous variation of specimen temperature from 8.75 K to 300 K with an optional temperature sweep rate. We use an external loading device to stretch the superconducting tape quasi-statically with the maximum tension strain of 20%. A superconducting magnet manufactured by the NbTi strand is applied to provide magnetic field up to 5 T with a homogeneous range of 110 mm. The maximum fluctuation of the magnetic field is less than 1%. We design a kind of superconducting lead composed of YBa2Cu3O7-x coated conductor and beryllium copper alloy (BeCu) to transfer DC to the superconducting sample with the maximum value of 600 A. Most notably, this apparatus allows in situ observation of the electromagnetic property of superconducting tape using the classical magnetic-optical imaging.

Simulation of the Velocity and Temperature Distribution of Inhalation Thermal Injury in a Human Upper Airway Model by Application of Computational Fluid Dynamics.

PubMed

Chang, Yang; Zhao, Xiao-zhuo; Wang, Cheng; Ning, Fang-gang; Zhang, Guo-an

2015-01-01

Inhalation injury is an important cause of death after thermal burns. This study was designed to simulate the velocity and temperature distribution of inhalation thermal injury in the upper airway in humans using computational fluid dynamics. Cervical computed tomography images of three Chinese adults were imported to Mimics software to produce three-dimensional models. After grids were established and boundary conditions were defined, the simulation time was set at 1 minute and the gas temperature was set to 80 to 320°C using ANSYS software (ANSYS, Canonsburg, PA) to simulate the velocity and temperature distribution of inhalation thermal injury. Cross-sections were cut at 2-mm intervals, and maximum airway temperature and velocity were recorded for each cross-section. The maximum velocity peaked in the lower part of the nasal cavity and then decreased with air flow. The velocities in the epiglottis and glottis were higher than those in the surrounding areas. Further, the maximum airway temperature decreased from the nasal cavity to the trachea. Computational fluid dynamics technology can be used to simulate the velocity and temperature distribution of inhaled heated air.

Assessment of Heat Hazard during the Polymerization of Selected Light-Sensitive Dental Materials.

PubMed

Janeczek, Maciej; Herman, Katarzyna; Fita, Katarzyna; Dudek, Krzysztof; Kowalczyk-Zając, Małgorzata; Czajczyńska-Waszkiewicz, Agnieszka; Piesiak-Pańczyszyn, Dagmara; Kosior, Piotr; Dobrzyński, Maciej

2016-01-01

Introduction. Polymerization of light-cured dental materials used for restoration of hard tooth tissue may lead to an increase in temperature that may have negative consequence for pulp vitality. Aim. The aim of this study was to determine maximum temperatures reached during the polymerization of selected dental materials, as well as the time that is needed for samples of sizes similar to those used in clinical practice to reach these temperatures. Materials and Methods. The study involved four composite restorative materials, one lining material and a dentine bonding agent. The polymerization was conducted with the use of a diode light-curing unit. The measurements of the external surface temperature of the samples were carried out using the Thermovision®550 thermal camera. Results. The examined materials significantly differed in terms of the maximum temperatures values they reached, as well as the time required for reaching the temperatures. A statistically significant positive correlation of the maximum temperature and the sample weight was observed. Conclusions. In clinical practice, it is crucial to bear in mind the risk of thermal damage involved in the application of light-cured materials. It can be reduced by using thin increments of composite materials.

Natural variability of the Keetch-Byram Drought Index in the Hawaiian Islands

Treesearch

Klaus Dolling; Pao-Shin Chu; Francis Fujioka

2009-01-01

The Hawaiian Islands experience damaging wildfires on a yearly basis. Soil moisture or lack thereof influences the amount and flammability of vegetation. Incorporating daily maximum temperatures and daily rainfall amounts, the Keetch–Byram Drought Index (KBDI) estimates the amount of soil moisture by tracking daily maximum temperatures and rainfall. A previous study...

A surface fuel classification for estimating fire effects

Treesearch

Duncan C. Lutes; Robert E. Keane; John F. Caratti

2009-01-01

We present a classification of duff, litter, fine woody debris, and logs that can be used to stratify a project area into sites with fuel loading that yield significantly different emissions and maximum soil surface temperature. Total particulate matter smaller than 2.5?m in diameter and maximum soil surface temperature were simulated using the First...

Hydrologic and climatic changes in three small watersheds after timber harvest.

Treesearch

W.B. Fowler; J.D. Helvey; E.N. Felix

1987-01-01

No significant increases in annual water yield were shown for three small watersheds in northeastern Oregon after shelterwood cutting (30-percent canopy removal, 50-percent basal area removal) and clearcutting. Average maximum air temperature increased after harvest and average minimum air temperature decreased by up to 2.6 °C. Both maximum and minimum water...

40 CFR Table 4 to Subpart Ffff of... - Emission Limits for Storage Tanks

Code of Federal Regulations, 2014 CFR

2014-07-01

... applies to your storage tanks: For each . . . For which . . . Then you must . . . 1. Group 1 storage tank a. The maximum true vapor pressure of total HAP at the storage temperature is ≥76.6 kilopascals i... maximum true vapor pressure of total HAP at the storage temperature is <76.6 kilopascals i. Comply with...

40 CFR Table 4 to Subpart Ffff of... - Emission Limits for Storage Tanks

Code of Federal Regulations, 2013 CFR

2013-07-01

... applies to your storage tanks: For each . . . For which . . . Then you must . . . 1. Group 1 storage tank a. The maximum true vapor pressure of total HAP at the storage temperature is ≥76.6 kilopascals i... maximum true vapor pressure of total HAP at the storage temperature is <76.6 kilopascals i. Comply with...

Heat Convection at the Density Maximum Point of Water

ERIC Educational Resources Information Center

Balta, Nuri; Korganci, Nuri

2018-01-01

Water exhibits a maximum in density at normal pressure at around 4° degree temperature. This paper demonstrates that during cooling, at around 4 °C, the temperature remains constant for a while because of heat exchange associated with convective currents inside the water. Superficial approach implies it as a new anomaly of water, but actually it…

Magnetization of Paraffin-Based Magnetic Nanocolloids

NASA Astrophysics Data System (ADS)

Dikanskii, Yu. I.; Ispiryan, A. G.; Kunikin, S. A.; Radionov, A. V.

2018-01-01

Using paraffin-based magnetic nanocolloids as an example, the reasons for maxima in the temperature dependence of the magnetic susceptibility of magnetic colloids have been discussed. The behavior of these dependences in a wide temperature interval has been analyzed for colloids in solid and liquid states. It has been concluded that the maximum observed at the melting point of paraffin can be attributed to freezing Brownian degrees of freedom in magnetite coarse particles, the magnetic moment of which is intimately related to the solid matrix. The second main maximum, which arises in the solid state, is explained by the superparamagnetic-magnetically hard transition of most fine particles at lower temperatures. It has been noted that the flatness of this maximum results from the polydispersity of the magnetic nanoparticle ensemble.

Note: Motor-piezoelectricity coupling driven high temperature fatigue device

NASA Astrophysics Data System (ADS)

Ma, Z. C.; Du, X. J.; Zhao, H. W.; Ma, X. X.; Jiang, D. Y.; Liu, Y.; Ren, L. Q.

2018-01-01

The design and performance evaluation of a novel high temperature fatigue device simultaneously driven by servo motor and piezoelectric actuator is our focus. The device integrates monotonic and cyclic loading functions with a maximum tensile load of 1800 N, driving frequency of 50 Hz, alternating load of 95 N, and maximum service temperature of 1200 °C. Multimodal fatigue tests with arbitrary combinations of static and dynamic loads are achieved. At temperatures that range from RT to 1100 °C, the tensile and tensile-fatigue coupling mechanical behaviors of UM Co50 alloys are investigated to verify the feasibility of the device.

Cross-scale modeling of surface temperature and tree seedling establishment inmountain landscapes

USGS Publications Warehouse

Dingman, John; Sweet, Lynn C.; McCullough, Ian M.; Davis, Frank W.; Flint, Alan L.; Franklin, Janet; Flint, Lorraine E.

2013-01-01

Abstract: Introduction: Estimating surface temperature from above-ground field measurements is important for understanding the complex landscape patterns of plant seedling survival and establishment, processes which occur at heights of only several centimeters. Currently, future climate models predict temperature at 2 m above ground, leaving ground-surface microclimate not well characterized. Methods: Using a network of field temperature sensors and climate models, a ground-surface temperature method was used to estimate microclimate variability of minimum and maximum temperature. Temperature lapse rates were derived from field temperature sensors and distributed across the landscape capturing differences in solar radiation and cold air drainages modeled at a 30-m spatial resolution. Results: The surface temperature estimation method used for this analysis successfully estimated minimum surface temperatures on north-facing, south-facing, valley, and ridgeline topographic settings, and when compared to measured temperatures yielded an R2 of 0.88, 0.80, 0.88, and 0.80, respectively. Maximum surface temperatures generally had slightly more spatial variability than minimum surface temperatures, resulting in R2 values of 0.86, 0.77, 0.72, and 0.79 for north-facing, south-facing, valley, and ridgeline topographic settings. Quasi-Poisson regressions predicting recruitment of Quercus kelloggii (black oak) seedlings from temperature variables were significantly improved using these estimates of surface temperature compared to air temperature modeled at 2 m. Conclusion: Predicting minimum and maximum ground-surface temperatures using a downscaled climate model coupled with temperature lapse rates estimated from field measurements provides a method for modeling temperature effects on plant recruitment. Such methods could be applied to improve projections of species’ range shifts under climate change. Areas of complex topography can provide intricate microclimates that may allow species to redistribute locally as climate changes.

Resistivity of a simple metal from room temperature to 10 to the 6th K

NASA Astrophysics Data System (ADS)

Milchberg, H. M.; Freeman, R. R.; Davey, S. C.; More, R. M.

1988-11-01

The resistivity of nearly solid-density Al was measured as a function of temperature over 4 orders of magnitude above ambient by observing the self-reflection of an intense, less than 0.5 psec, 308-nm light pulse incident on a planar Al target. As an increasing function of electron temperature, the resistivity is observed initially to increase, reach a maximum which is relatively constant over an extended temperature range, and then decrease at the highest temperatures. The broad maximum is interpreted as resistivity saturation, a condition in which the mean free path of the conduction electrons reaches a minimum value as a function of temperature, regardless of the extent of any further disorder in the material.

Relaxation of a High-Energy Quasiparticle in a One-Dimensional Bose Gas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tan, Shina; Glazman, Leonid I.; Pustilnik, Michael

2010-08-27

We evaluate the relaxation rate of high-energy quasiparticles in a weakly interacting one-dimensional Bose gas. Unlike in higher dimensions, the rate is a nonmonotonic function of temperature, with a maximum at the crossover to the state of suppressed density fluctuations. At the maximum, the relaxation rate may significantly exceed its zero-temperature value. We also find the dependence of the differential inelastic scattering rate on the transferred energy. This rate yields information about temperature dependence of local pair correlations.

REMARKS ON THE MAXIMUM ENTROPY METHOD APPLIED TO FINITE TEMPERATURE LATTICE QCD.

DOE Office of Scientific and Technical Information (OSTI.GOV)

UMEDA, T.; MATSUFURU, H.

2005-07-25

We make remarks on the Maximum Entropy Method (MEM) for studies of the spectral function of hadronic correlators in finite temperature lattice QCD. We discuss the virtues and subtlety of MEM in the cases that one does not have enough number of data points such as at finite temperature. Taking these points into account, we suggest several tests which one should examine to keep the reliability for the results, and also apply them using mock and lattice QCD data.

A study of the asteroid (367943) Duende at Pulkovo Observatory

NASA Astrophysics Data System (ADS)

Devyatkin, A. V.; Gorshanov, D. L.; Yershov, V. N.; Melnikov, A. V.; Martyusheva, A. A.; Petrova, S. N.; L'vov, V. N.; Tsekmeister, S. D.; Naumov, K. N.

2016-07-01

Using the telescopes ZA-320 M and MTM-500 M of Pulkovo Observatory (Russia), we have carried out astrometric and photometric observations of the asteroid (367943) Duende (2012 DA14) immediately after its close approach to the Earth occurred on 2013 February 15. We have obtained a series of its astrometric positions, colour indices and two fragments of its light curve. By numerically integrating, we have studied the evolution of the asteroid's orbit. Also, the influence of solar radiation pressure and Yarkovsky effect on the asteroid was estimated. The fitting of the asteroid rotation model to the observed light curve indicates that during its closest approach to the Earth, it had tumbling rotation regime.

Geology of a Portion of the Martian Highlands: MTMs -20002, -20007, -25002 and -25007

NASA Technical Reports Server (NTRS)

Fortezzo, C. M.; Williams, K. K.

2009-01-01

As part of a continuing study to understand the relationship between valleys and highland resurfacing through geologic mapping, we are continuing to map seven MTM quads in portions of the Margaritifer, Arabia, and Noachis Terrae. Results from this mapping will also help constrain the role and extent of past water in the region. The MTMs are grouped in two different areas: a 4-quadrangle area (-20002, -20007, -25002, -25007) and an L-shaped area (-15017, -20017, -20022) within the region [1-5]. This abstract focuses on the geologic units and history from mapping in the 4-quadrangle area, but includes a brief update on the L-shaped map area.

Comparison of High-Speed Operating Characteristics of Size 215 Cylindrical-Roller Bearings as Determined in Turbojet Engine and in Laboratory Test Rig

NASA Technical Reports Server (NTRS)

Macks, E Fred; Nemeth, Zolton N

1951-01-01

A comparison of the operating characteristics of 75-millimeter-bore (size 215) cylindrical-roller one-piece inner-race-riding cage-type bearings was made using a laboratory test rig and a turbojet engine. Cooling correlation parameters were determined by means of dimensional analysis, and the generalized results for both the inner- and outer-race bearing operating temperatures are compared for the laboratory test rig and the turbojet engine. Inner- and outer-race cooling-correlation curves were obtained for the turbojet-engine turbine-roller bearing with the same inner- and outer-race correlation parameters and exponents as those determined for the laboratory test-rig bearing. The inner- and outer-race turbine roller-bearing temperatures may be predicted from a single curve, regardless of variations in speed, load, oil flow, oil inlet temperature, oil inlet viscosity, oil-jet diameter or any combination of these parameters. The turbojet-engine turbine-roller-bearing inner-race temperatures were 30 to 60 F greater than the outer-race-maximum temperatures, the exact values depending on the operating condition and oil viscosity; these results are in contrast to the laboratory test-rig results where the inner-race temperatures were less than the outer-race-maximum temperatures. The turbojet-engine turbine-roller bearing, maximum outer-race circumferential temperature variation was approximately 30 F for each of the oils used. The effect of oil viscosity on inner- and outer-race turbojet-engine turbine-roller-bearing temperatures was found to be significant. With the lower viscosity oil (6x10(exp -7) reyns (4.9 centistokes) at 100 F; viscosity index, 83), the inner-race temperature was approximately 30 to 35 F less than with the higher viscosity oil (53x10(exp -7) reyns (42.8 centistokes) at 100 F; viscosity index, 150); whereas the outer-race-maximum temperatures were 12 to 28 F lower with the lower viscosity oil over the DN range investigated.

Effect of temperature and humidity on pathogenicity of native Beauveria bassiana isolate against Musca domestica L.

PubMed

Mishra, Sapna; Kumar, Peeyush; Malik, Anushree

2015-12-01

Beauveria bassiana HQ917687 virulence to housefly larvae and adult was assessed at different relative humidity, RH (50, 75, 90, and 100 %) and temperature (15, 20, 25, 30, 35, 40, 45 °C) conditions at the fungal dose of 10(8) conidia/ml. Depending on the temperature and RH regime tested, difference in mortality rates of housefly adult and larvae were detected. During assay on adult housefly, 100 % mortality was achieved at RH, 90 and 100 % while the temperature of 30 °C showed maximum mortality at all the tested humidity conditions. Lethal time, LT50 was 2.9 days at 100 % RH. Larval mortality at different humidity conditions varied between 30 and 74 %, with maximum mortality at 100 % RH and 30 °C. Optimum temperature for B. bassiana virulence to housefly larvae was also found to be 30 °C. The interaction between temperature and RH revealed significant effect of RH at moderate temperature range (20-35 °C), while such an interaction was not observed at extreme temperatures. The results obtained in this study have useful implications in understanding the pathogen behavior under actual field conditions. This in turn may help devising suitable entomopathogen release schedules for maximum fungal infection.

Summer temperature metrics for predicting brook trout (Salvelinus fontinalis) distribution in streams

USGS Publications Warehouse

Parrish, Donna; Butryn, Ryan S.; Rizzo, Donna M.

2012-01-01

We developed a methodology to predict brook trout (Salvelinus fontinalis) distribution using summer temperature metrics as predictor variables. Our analysis used long-term fish and hourly water temperature data from the Dog River, Vermont (USA). Commonly used metrics (e.g., mean, maximum, maximum 7-day maximum) tend to smooth the data so information on temperature variation is lost. Therefore, we developed a new set of metrics (called event metrics) to capture temperature variation by describing the frequency, area, duration, and magnitude of events that exceeded a user-defined temperature threshold. We used 16, 18, 20, and 22°C. We built linear discriminant models and tested and compared the event metrics against the commonly used metrics. Correct classification of the observations was 66% with event metrics and 87% with commonly used metrics. However, combined event and commonly used metrics correctly classified 92%. Of the four individual temperature thresholds, it was difficult to assess which threshold had the “best” accuracy. The 16°C threshold had slightly fewer misclassifications; however, the 20°C threshold had the fewest extreme misclassifications. Our method leveraged the volumes of existing long-term data and provided a simple, systematic, and adaptable framework for monitoring changes in fish distribution, specifically in the case of irregular, extreme temperature events.

Analytical Assessment of the Relationship between 100MWp Large-scale Grid-connected Photovoltaic Plant Performance and Meteorological Parameters

NASA Astrophysics Data System (ADS)

Sheng, Jie; Zhu, Qiaoming; Cao, Shijie; You, Yang

2017-05-01

This paper helps in study of the relationship between the photovoltaic power generation of large scale “fishing and PV complementary” grid-tied photovoltaic system and meteorological parameters, with multi-time scale power data from the photovoltaic power station and meteorological data over the same period of a whole year. The result indicates that, the PV power generation has the most significant correlation with global solar irradiation, followed by diurnal temperature range, sunshine hours, daily maximum temperature and daily average temperature. In different months, the maximum monthly average power generation appears in August, which related to the more global solar irradiation and longer sunshine hours in this month. However, the maximum daily average power generation appears in October, this is due to the drop in temperature brings about the improvement of the efficiency of PV panels. Through the contrast of monthly average performance ratio (PR) and monthly average temperature, it is shown that, the larger values of monthly average PR appears in April and October, while it is smaller in summer with higher temperature. The results concluded that temperature has a great influence on the performance ratio of large scale grid-tied PV power system, and it is important to adopt effective measures to decrease the temperature of PV plant properly.

Effects of temperature on the gas exchange of leaves in the light and dark.

PubMed

Hofstra, G; Hesketh, J D

1969-09-01

Evolution of CO2 into CO2-free air was measured in the light and in the dark over a range of temperatures from 15 to 50°. Photosynthetic rates were measured in air and O2-free air over the same range of temperatures. Respiration in the light had a different sensitivity to temperature compared with respiration in the dark. At the lower temperatures the rate of respiration in the light was higher than respiration in the dark, whereas at temperatures above 40° the reverse was observed. For any one species the maximum rates of photosynthesis and photorespiration occur at about the same temperature. The maximum rate for dark respiration generally is found at a temperature about 10° higher. Zea mays and Atriplex nummularia showed no enhancement of photosynthesis in O2-free air nor any evolution of CO2 in CO2-free air at any of the temperatures.

Numerical simulation of CO2 scroll compressor in transcritical compression cycle

NASA Astrophysics Data System (ADS)

Wang, Hongli; Tian, JingRui; Du, Yuanhang; Hou, Xiujuan

2018-05-01

Based on the theory of thermodynamics and kinetics, the mathematical model of an orbiting scroll was established and the stress deformations were employed by ANSYS software. Under the action of pressure load, the results show that the serious displacement part is located in the center of the gear head and the maximum deformation is about 7.33 μm. The maximum radial displacement is about 4.42 μm. The maximum radial stress point occurs in the center of the gear head and the maximum stress is about 40.9 MPa. The maximum axial displacement is about 2.31 μm. The maximum axial stress point occurs in the gear head and the maximum stress is about 44.7 MPa. Under the action of temperature load, the results show that the serious deformation part is located in the center of the gear head and the maximum deformation is about 6.3 μm. The maximum thermal stress occurs in the center of the gear head and the maximum thermal stress is about 86.36 MPa. Under the combined action of temperature load and pressure load, the results show that the serious deformation part and the maximum stress are located in the center of the gear head, and the value are about 7.79 μm and 74.19 MPa, respectively.

Combustion synthesis of ceramic and metal-matrix composites

NASA Technical Reports Server (NTRS)

Moore, John J.; Feng, Heng J.; Hunter, Kevin J.; Wirth, David G.

1993-01-01

Combustion synthesis or self-propagating high temperature synthesis (SHS) is effected by heating a reactant mixture, to above the ignition temperature (Tig) whereupon an exothermic reaction is initiated which produces a maximum or combustion temperature, Tc. These SHS reactions are being used to produce ceramics, intermetallics, and composite materials. One of the major limitations of this process is that relatively high levels of porosity, e.g., 50 percent, remain in the product. Conducting these SHS reactions under adiabatic conditions, the maximum temperature is the adiabatic temperature, Tad, and delta H (Tad) = 0, Tad = Tc. If the reactants or products go through a phase change, the latent heat of transformation needs to be taken into account.

Review of specimen heating in mechanical tests at cryogenic temperatures

NASA Astrophysics Data System (ADS)

Ogata, T.; Yuri, T.; Ono, Y.

2014-01-01

At cryogenic temperatures near 4 K, a discontinuous deformation produces a large amount of specimen temperature rise that might bring significant changes in mechanical properties. The authors measured the specimen heating in tensile tests, fatigue test, and other tests in liquid helium for stainless steels and other materials. In this paper, we have measured the specimen temperature in high-cycle and low-cycle fatigue tests for stainless steels at various frequencies and stress levels and evaluated the testing conditions to keep the specimen at a specified temperature. We proposed maximum frequency in load-controlled fatigue tests for specified loading variables and a maximum strain rate in strain-controlled fatigue tests.

An Active Fire Temperature Retrieval Model Using Hyperspectral Remote Sensing

NASA Astrophysics Data System (ADS)

Quigley, K. W.; Roberts, D. A.; Miller, D.

2017-12-01

Wildfire is both an important ecological process and a dangerous natural threat that humans face. In situ measurements of wildfire temperature are notoriously difficult to collect due to dangerous conditions. Imaging spectrometry data has the potential to provide some of the most accurate and highest temporally-resolved active fire temperature retrieval information for monitoring and modeling. Recent studies on fire temperature retrieval have used have used Multiple Endmember Spectral Mixture Analysis applied to Airborne Visible applied to Airborne Visible / Infrared Imaging Spectrometer (AVIRIS) bands to model fire temperatures within the regions marked to contain fire, but these methods are less effective at coarser spatial resolutions, as linear mixing methods are degraded by saturation within the pixel. The assumption of a distribution of temperatures within pixels allows us to model pixels with an effective maximum and likely minimum temperature. This assumption allows a more robust approach to modeling temperature at different spatial scales. In this study, instrument-corrected radiance is forward-modeled for different ranges of temperatures, with weighted temperatures from an effective maximum temperature to a likely minimum temperature contributing to the total radiance of the modeled pixel. Effective maximum fire temperature is estimated by minimizing the Root Mean Square Error (RMSE) between modeled and measured fires. The model was tested using AVIRIS collected over the 2016 Sherpa Fire in Santa Barbara County, California,. While only in situ experimentation would be able to confirm active fire temperatures, the fit of the data to modeled radiance can be assessed, as well as the similarity in temperature distributions seen on different spatial resolution scales. Results show that this model improves upon current modeling methods in producing similar effective temperatures on multiple spatial scales as well as a similar modeled area distribution of those temperatures.

High-temperature responses of North American cacti

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, S.D.; Didden-Zopfy, B.; Nobel, P.S.

1984-04-01

High-temperature tolerances of 14 species of North American cacti were investigated. A reduction in the proportion of chlorenchyma cells taking up a vital stain (neutral red) and reduced nocturnal acid accumulation were used as indicators of high-temperature damage. All species tolerated relatively high tissue temperatures, the mean maximum tolerance being 64/sup 0/C, with an absolute maximum of 69/sup 0/ for two species of ferocactus. Such tissue tolerances to high temperature may be unsurpassed in vascular plants. Morphological features can affect tissue temperatures. Specifically, thin-stemmed species such as the cylindropuntias attain lower maximum temperatures under identical microclimatic conditions than do moremore » massive species; they also tend to be less tolerant of high-temperature stress. Stem diameter changes of three species of columnar ceriod cacti along a Sonoran Desert latitudinal transect were previously attributed to adaptation to progressively colder temperatures northward. Such changes can also be interpreted as a morphological adaptation to high temperatures, particularly in the southern Sonoran Desert. Interspecific differences in high-temperature tolerance may account for distributional differences among other species. Acclimation of high-temperature tolerances in response to increasing day/night air temperatures was observed in all 14 species, especially at higher growh temperatures. From 40/sup 0/ day/30/sup 0/ night to 50/sup 0//40/sup 0/, the tolerable tissue temperatures increased an average of 6/sup 0/. Half-times for the acclimation shifts were 1-3d. Although cacti attain extremely high tissue temperatures in desert habitats, tolerance of high temperatures and pronounced acclimation potential allow them to occur in some of the hottest habitats in North America.« less

Impact of Land Surface Initialization Approach on Subseasonal Forecast Skill: a Regional Analysis in the Southern Hemisphere

NASA Technical Reports Server (NTRS)

Hirsch, Annette L.; Kala, Jatin; Pitman, Andy J.; Carouge, Claire; Evans, Jason P.; Haverd, Vanessa; Mocko, David

2014-01-01

The authors use a sophisticated coupled land-atmosphere modeling system for a Southern Hemisphere subdomain centered over southeastern Australia to evaluate differences in simulation skill from two different land surface initialization approaches. The first approach uses equilibrated land surface states obtained from offline simulations of the land surface model, and the second uses land surface states obtained from reanalyses. The authors find that land surface initialization using prior offline simulations contribute to relative gains in subseasonal forecast skill. In particular, relative gains in forecast skill for temperature of 10%-20% within the first 30 days of the forecast can be attributed to the land surface initialization method using offline states. For precipitation there is no distinct preference for the land surface initialization method, with limited gains in forecast skill irrespective of the lead time. The authors evaluated the asymmetry between maximum and minimum temperatures and found that maximum temperatures had the largest gains in relative forecast skill, exceeding 20% in some regions. These results were statistically significant at the 98% confidence level at up to 60 days into the forecast period. For minimum temperature, using reanalyses to initialize the land surface contributed to relative gains in forecast skill, reaching 40% in parts of the domain that were statistically significant at the 98% confidence level. The contrasting impact of the land surface initialization method between maximum and minimum temperature was associated with different soil moisture coupling mechanisms. Therefore, land surface initialization from prior offline simulations does improve predictability for temperature, particularly maximum temperature, but with less obvious improvements for precipitation and minimum temperature over southeastern Australia.

Non-linear effects of mean temperature and relative humidity on dengue incidence in Guangzhou, China.

PubMed

Wu, Xiaocheng; Lang, Lingling; Ma, Wenjun; Song, Tie; Kang, Min; He, Jianfeng; Zhang, Yonghui; Lu, Liang; Lin, Hualiang; Ling, Li

2018-07-01

Dengue fever is an important infectious disease in Guangzhou, China; previous studies on the effects of weather factors on the incidence of dengue fever did not consider the linearity of the associations. This study evaluated the effects of daily mean temperature, relative humidity and rainfall on the incidence of dengue fever. A generalized additive model with splines smoothing function was performed to examine the effects of daily mean, minimum and maximum temperatures, relative humidity and rainfall on incidence of dengue fever during 2006-2014. Our analysis detected a non-linear effect of mean, minimum and maximum temperatures and relative humidity on dengue fever with the thresholds at 28°C, 23°C and 32°C for daily mean, minimum and maximum temperatures, 76% for relative humidity, respectively. Below the thresholds, there was a significant positive effect, the excess risk in dengue fever for each 1°C in the mean temperature at lag7-14days was 10.21%, (95% CI: 6.62% to 13.92%), 7.10% (95% CI: 4.99%, 9.26%) for 1°C increase in daily minimum temperature in lag 11days, and 2.27% (95% CI: 0.84%, 3.72%) for 1°C increase in daily maximum temperature in lag 10days; and each 1% increase in relative humidity of lag7-14days was associated with 1.95% (95% CI: 1.21% to 2.69%) in risk of dengue fever. Future prevention and control measures and epidemiology studies on dengue fever should consider these weather factors based on their exposure-response relationship. Copyright © 2018. Published by Elsevier B.V.

Changes in heat waves indices in Romania over the period 1961-2015

NASA Astrophysics Data System (ADS)

Croitoru, Adina-Eliza; Piticar, Adrian; Ciupertea, Antoniu-Flavius; Roşca, Cristina Florina

2016-11-01

In the last two decades many climate change studies have focused on extreme temperatures as they have a significant impact on environment and society. Among the weather events generated by extreme temperatures, heat waves are some of the most harmful. The main objective of this study was to detect and analyze changes in heat waves in Romania based on daily observation data (maximum and minimum temperature) over the extended summer period (May-Sept) using a set of 10 indices and to explore the spatial patterns of changes. Heat wave data series were derived from daily maximum and minimum temperature data sets recorded in 29 weather stations across Romania over a 55-year period (1961-2015). In this study, the threshold chosen was the 90th percentile calculated based on a 15-day window centered on each calendar day, and for three baseline periods (1961-1990, 1971-2000, and 1981-2010). Two heat wave definitions were considered: at least three consecutive days when maximum temperature exceeds 90th percentile, and at least three consecutive days when minimum temperature exceeds 90th percentile. For each of them, five variables were calculated: amplitude, magnitude, number of events, duration, and frequency. Finally, 10 indices resulted for further analysis. The main results are: most of the indices have statistically significant increasing trends; only one index for one weather station indicated statistically significant decreasing trend; the changes are more intense in case of heat waves detected based on maximum temperature compared to those obtained for heat waves identified based on minimum temperature; western and central regions of Romania are the most exposed to increasing heat waves.