The k-d Tree: A Hierarchical Model for Human Cognition.

ERIC Educational Resources Information Center

Vandendorpe, Mary M.

This paper discusses a model of information storage and retrieval, the k-d tree (Bentley, 1975), a binary, hierarchical tree with multiple associate terms, which has been explored in computer research, and it is suggested that this model could be useful for describing human cognition. Included are two models of human long-term memory--networks and…

Reducing the Risk of Human Missions to Mars Through Testing

NASA Astrophysics Data System (ADS)

Drake, Bret G.

2007-07-01

The NASA Deputy Administrator charted an internal NASA planning group to develop the rationale for exploration beyond low-Earth orbit. This team, termed the Exploration Blueprint, performed architecture analyses to develop roadmaps for how to accomplish the first steps beyond Low-Earth Orbit through the human exploration of Mars. Following the results of the Exploration Blueprint study, the NASA Administrator asked for a recommendation on the next steps in human and robotic exploration. Much of the focus during this period was on integrating the results from the previous studies into more concrete implementation strategies in order to understand the relationship between NASA programs, timing, and resulting budgetary implications. This resulted in an integrated approach including lunar surface operations to retire risk of human Mars missions, maximum use of common and modular systems including what was termed the exploration transfer vehicle, Earth orbit and lunar surface demonstrations of long-life systems, collaboration of human and robotic missions to vastly increase mission return, and high-efficiency transportation systems (nuclear) for deep-space transportation and power. The data provided in this summary presentation was developed to begin to address one of the key elements of the emerging implementation strategy, namely how lunar missions help retire risk of human missions to Mars. During this process the scope of the activity broadened into the issue of how testing in general, in various venues including the moon, can help reduce the risk for Mars missions.

Contamination Mitigation Strategies for Long Duration Human Spaceflight Missions

NASA Technical Reports Server (NTRS)

Lewis, Ruthan; Lupisella, Mark; Bleacher, Jake; Farrell, William

2017-01-01

Contamination control issues are particularly challenging for long-term human spaceflight and are associated with the search for life, dynamic environmental conditions, human-robotic-environment interaction, sample collection and return, biological processes, waste management, long-term environmental disturbance, etc. These issues impact mission success, human health, planetary protection, and research and discovery. Mitigation and control techniques and strategies may include and integrate long-term environmental monitoring and reporting, contamination control and planetary protection protocols, habitation site design, habitat design, and surface exploration and traverse pathways and area access planning.

Peer-to-Peer Human-Robot Interaction for Space Exploration

NASA Technical Reports Server (NTRS)

Fong, Terrence; Nourbakhsh, Illah

2004-01-01

NASA has embarked on a long-term program to develop human-robot systems for sustained, affordable space exploration. To support this mission, we are working to improve human-robot interaction and performance on planetary surfaces. Rather than building robots that function as glorified tools, our focus is to enable humans and robots to work as partners and peers. In this paper. we describe our approach, which includes contextual dialogue, cognitive modeling, and metrics-based field testing.

An International Strategy for Human Exploration of the Moon: The International Space Exploration Coordination Group (ISECG) Reference Architecture for Human Lunar Exploration

NASA Technical Reports Server (NTRS)

Laurini, Kathleen C.; Hufenbach, Bernhard; Junichiro, Kawaguchi; Piedboeuf, Jean-Claude; Schade, Britta; Lorenzoni, Andrea; Curtis, Jeremy; Hae-Dong, Kim

2010-01-01

The International Space Exploration Coordination Group (ISECG) was established in response to The Global Exploration Strategy: The Framework for Coordination developed by fourteen space agencies and released in May 2007. Several ISECG participating space agencies have been studying concepts for human exploration of the moon that allow individual and collective goals and objectives to be met. This 18 month study activity culminated with the development of the ISECG Reference Architecture for Human Lunar Exploration. The reference architecture is a series of elements delivered over time in a flexible and evolvable campaign. This paper will describe the reference architecture and how it will inform near-term and long-term programmatic planning within interested agencies. The reference architecture is intended to serve as a global point of departure conceptual architecture that enables individual agency investments in technology development and demonstration, International Space Station research and technology demonstration, terrestrial analog studies, and robotic precursor missions to contribute towards the eventual implementation of a human lunar exploration scenario which reflects the concepts and priorities established to date. It also serves to create opportunities for partnerships that will support evolution of this concept and its eventual realization. The ISECG Reference Architecture for Human Lunar Exploration (commonly referred to as the lunar gPoD) reflects the agency commitments to finding an effective balance between conducting important scientific investigations of and from the moon, as well as demonstrating and mastering the technologies and capabilities to send humans farther into the Solar System. The lunar gPoD begins with a robust robotic precursor phase that demonstrates technologies and capabilities considered important for the success of the campaign. Robotic missions will inform the human missions and buy down risks. Human exploration will start with a thorough scientific investigation of the polar region while allowing the ability to demonstrate and validate the systems needed to take humans on more ambitious lunar exploration excursions. The ISECG Reference Architecture for Human Lunar Exploration serves as a model for future cooperation and is documented in a summary report and a comprehensive document that also describes the collaborative international process that led to its development. ISECG plans to continue with architecture studies such as this to examine an open transportation architecture and other destinations, with expanded participation from ISECG agencies, as it works to inform international partnerships and advance the Global Exploration Strategy.

Space Resource Utilization: Near-Term Missions and Long-Term Plans for Human Exploration

NASA Technical Reports Server (NTRS)

Sanders, Gerald B.

2015-01-01

NASA's Human Exploration Plans: A primary goal of all major space faring nations is to explore space: from the Earth with telescopes, with robotic probes and space telescopes, and with humans. For the US National Aeronautics and Space Administration (NASA), this pursuit is captured in three important strategic goals: 1. Ascertain the content, origin, and evolution of the solar system and the potential for life elsewhere, 2. Extend and sustain human activities across the solar system (especially the surface of Mars), and 3. Create innovative new space technologies for exploration, science, and economic future. While specific missions and destinations are still being discussed as to what comes first, it is imperative for NASA that it foster the development and implementation of new technologies and approaches that make space exploration affordable and sustainable. Critical to achieving affordable and sustainable human exploration beyond low Earth orbit (LEO) is the development of technologies and systems to identify, extract, and use resources in space instead of bringing everything from Earth. To reduce the development and implementation costs for space resource utilization, often called In Situ Resource Utilization (ISRU), it is imperative to work with terrestrial mining companies to spin-in/spin-off technologies and capabilities, and space mining companies to expand our economy beyond Earth orbit. In the last two years, NASA has focused on developing and implementing a sustainable human space exploration program with the ultimate goal of exploring the surface of Mars with humans. The plan involves developing technology and capability building blocks critical for sustained exploration starting with the Space Launch System (SLS) and Orion crew spacecraft and utilizing the International Space Station as a springboard into the solar system. The evolvable plan develops and expands human exploration in phases starting with missions that are reliant on Earth, to performing ever more challenging and longer duration missions in cis-lunar space and beyond, to eventually being independent from Earth. The goal is no longer just to reach a destination, but to enable people to work, learn, operate, and live safely beyond the Earth for extended periods of time, ultimately in ways that are more sustainable and even indefinite.

Preparing for Human Exploration

NASA Technical Reports Server (NTRS)

Drake, Bret G.; Joosten, B. Kent

1998-01-01

NASA's Human Exploration and Development of Space (HEDS) Enterprise is defining architectures and requirements for human exploration that radically reduce the costs of such missions through the use of advanced technologies, commercial partnerships and innovative systems strategies. In addition, the HEDS Enterprise is collaborating with the Space Science Enterprise to acquire needed early knowledge about Mars and to demonstrate critical technologies via robotic missions. This paper provides an overview of the technological challenges facing NASA as it prepares for human exploration. Emphasis is placed on identifying the key technologies including those which will provide the most return in terms of reducing total mission cost and/or reducing potential risk to the mission crew. Top-level requirements are provided for those critical enabling technology options currently under consideration.

A Mission Concept Based on the ISECG Human Lunar Surface Architecture

NASA Technical Reports Server (NTRS)

Gruener, J. E.; Lawrence, S. J.

2017-01-01

The National Aeronautics and Space Administration (NASA) is participating in the International Space Exploration Coordination Group (ISECG), working together with 13 other space agencies to advance a long-range human space exploration strategy. The ISECG has developed a Global Exploration Roadmap (GER) that reflects the coordinated international dialog and continued preparation for exploration beyond low-Earth orbit - beginning with the International Space Station (ISS) and continuing to the Moon, near-Earth asteroids, and Mars [1]. The roadmap demonstrates how initial capabilities can enable a variety of missions in the lunar vicinity, responding to individual and common goals and objectives, while contributing to building partnerships required for sustainable human space exploration that delivers value to the public. The current GER includes three different near-term themes: exploration of a near-Earth asteroid, extended duration crew missions in cis-lunar space, and humans to the lunar surface.

NASA Space Exploration Logistics Workshop Proceedings

NASA Technical Reports Server (NTRS)

deWeek, Oliver; Evans, William A.; Parrish, Joe; James, Sarah

2006-01-01

As NASA has embarked on a new Vision for Space Exploration, there is new energy and focus around the area of manned space exploration. These activities encompass the design of new vehicles such as the Crew Exploration Vehicle (CEV) and Crew Launch Vehicle (CLV) and the identification of commercial opportunities for space transportation services, as well as continued operations of the Space Shuttle and the International Space Station. Reaching the Moon and eventually Mars with a mix of both robotic and human explorers for short term missions is a formidable challenge in itself. How to achieve this in a safe, efficient and long-term sustainable way is yet another question. The challenge is not only one of vehicle design, launch, and operations but also one of space logistics. Oftentimes, logistical issues are not given enough consideration upfront, in relation to the large share of operating budgets they consume. In this context, a group of 54 experts in space logistics met for a two-day workshop to discuss the following key questions: 1. What is the current state-of the art in space logistics, in terms of architectures, concepts, technologies as well as enabling processes? 2. What are the main challenges for space logistics for future human exploration of the Moon and Mars, at the intersection of engineering and space operations? 3. What lessons can be drawn from past successes and failures in human space flight logistics? 4. What lessons and connections do we see from terrestrial analogies as well as activities in other areas, such as U.S. military logistics? 5. What key advances are required to enable long-term success in the context of a future interplanetary supply chain? These proceedings summarize the outcomes of the workshop, reference particular presentations, panels and breakout sessions, and record specific observations that should help guide future efforts.

Strategic Implications of Human Exploration of Near-Earth Asteroids

NASA Technical Reports Server (NTRS)

Drake, Bret G.

2011-01-01

The current United States Space Policy [1] as articulated by the White House and later confirmed by the Congress [2] calls for [t]he extension of the human presence from low-Earth orbit to other regions of space beyond low-Earth orbit will enable missions to the surface of the Moon and missions to deep space destinations such as near-Earth asteroids and Mars. Human exploration of the Moon and Mars has been the focus of numerous exhaustive studies and planning, but missions to Near-Earth Asteroids (NEAs) has, by comparison, garnered relatively little attention in terms of mission and systems planning. This paper examines the strategic implications of human exploration of NEAs and how they can fit into the overall exploration strategy. This paper specifically addresses how accessible NEAs are in terms of mission duration, technologies required, and overall architecture construct. Example mission architectures utilizing different propulsion technologies such as chemical, nuclear thermal, and solar electric propulsion were formulated to determine resulting figures of merit including number of NEAs accessible, time of flight, mission mass, number of departure windows, and length of the launch windows. These data, in conjunction with what we currently know about these potential exploration targets (or need to know in the future), provide key insights necessary for future mission and strategic planning.

Human Exploration and Development of Space: Strategic Plan

NASA Technical Reports Server (NTRS)

Branscome, Darrell (Editor); Allen, Marc (Editor); Bihner, William (Editor); Cooke, Douglas (Editor); Craig, Mark (Editor); Crouch, Matthew (Editor); Crouch, Roger (Editor); Flaherty, Chris (Editor); Haynes, Norman (Editor); Horowitz, Steven (Editor)

2001-01-01

In order to make possible the permanent extension of human presence beyond the bounds of Earth and enable historic improvements in our understanding of our solar system and the universe, and the quality of life, NASA must: (1) Undertake, in partnership with the scientific community, sustained international explorations throughout the inner solar system by integrated human/robotic expeditions; (2) Achieve breakthrough discoveries and technology developments through basic, applied, and commercial research in the unique venue of space--exploiting characteristics such as microgravity, vacuum, radiation, and location; (3) Establish safe and routine access to space in support of permanent commercial human operations in low-Earth orbit and ongoing exploration activities at one or more sites beyond Earth orbit; (4) Engage the private sector in the commercial development of space and enable the creation of new space industries generating new wealth for the US economy; and (5) Communicate the excitement and importance of the discovery of new worlds and the profound insights we will gain into the origins of life and the universe. In order to guide planning, the Human Exploration and Development of Space (HEDS) Enterprise has identified some potential future targets and goals (e.g. 'Design Reference Points') beginning with the near-term and extending to the far-term and beyond.

Future Visions for Scientific Human Exploration

NASA Astrophysics Data System (ADS)

Garvin, James

2002-01-01

Human exploration has always played a vital role within NASA, in spite of current perceptions that today it is adrift as a consequence of the resource challenges associated with construction and operation of the International Space Station (ISS). On the basis of the significance of human spaceflight within NASA's overall mission, periodic evaluation of its strategic position has been conducted by various groups, most recently exemplified by the recent Human Exploration and Development of Space Enterprise Strategic Plan. While such reports paint one potential future pathway, they are necessarily constrained by the ground rules and assumptions under which they are developed. An alternate approach, involving a small team of individuals selected as "brainstormers," has been ongoing within NASA for the past two years in an effort to capture a vision of a long-term future for human spaceflight not limited by nearer-term "point design" solutions. This paper describes the guiding principles and concepts developed by this team. It is not intended to represent an implementation plan, but rather one perspective on what could result as human beings extend their range of experience in spaceflight beyond today's beach-head of Low-Earth Orbit (LEO).

A Simple Exploration of Complexity at the Climate-Weather-Social-Conflict Nexus

NASA Astrophysics Data System (ADS)

Shaw, M.

2017-12-01

The conceptualization, exploration, and prediction of interplay between climate, weather, important resources, and social and economic - so political - human behavior is cast, and analyzed, in terms familiar from statistical physics and nonlinear dynamics. A simple threshold toy model is presented which emulates human tendencies to either actively engage in responses deriving, in part, from environmental circumstances or to maintain some semblance of status quo, formulated based on efforts drawn from the sociophysics literature - more specifically vis a vis a model akin to spin glass depictions of human behavior - with threshold/switching of individual and collective dynamics influenced by relatively more detailed weather and land surface model (hydrological) analyses via a land data assimilation system (a custom rendition of the NASA GSFC Land Information System). Parameters relevant to human systems' - e.g., individual and collective switching - sensitivity to hydroclimatology are explored towards investigation of overall system behavior; i.e., fixed points/equilibria, oscillations, and bifurcations of systems composed of human interactions and responses to climate and weather through, e.g., agriculture. We discuss implications in terms of conceivable impacts of climate change and associated natural disasters on socioeconomics, politics, and power transfer, drawing from relatively recent literature concerning human conflict.

Use of acoustic tools to reveal otherwise cryptic responses of forest elephants to oil exploration.

PubMed

Wrege, Peter H; Rowland, Elizabeth D; Thompson, Bruce G; Batruch, Nikolas

2010-12-01

Most evaluations of the effects of human activities on wild animals have focused on estimating changes in abundance and distribution of threatened species; however, ecosystem disturbances also affect aspects of animal behavior such as short-term movement, activity budgets, and reproduction. It may take a long time for changes in behavior to manifest as changes in abundance or distribution. Therefore, it is important to have methods with which to detect short-term behavioral responses to human activity. We used continuous acoustic and seismic monitoring to evaluate the short-term effects of seismic prospecting for oil on forest elephants (Loxodonta cyclotis) in Gabon, Central Africa. We monitored changes in elephant abundance and activity as a function of the frequency and intensity of acoustic and seismic signals from dynamite detonation and human activity. Elephants did not flee the area being explored; the relative number of elephants increased in a seasonal pattern typical of elsewhere in the ecosystem. In the exploration area, however, they became more nocturnal. Neither the intensity nor the frequency of dynamite blasts affected the frequency of calling or the daily pattern of elephant activity. Nevertheless, the shift of activity to nocturnal hours became more pronounced as human activity neared each monitored area of forest. This change in activity pattern and its likely causes would not have been detected through standard monitoring methods, which are not sensitive to behavioral changes over short time scales (e.g., dung transects, point counts) or cover a limited area (e.g., camera traps). Simultaneous acoustic monitoring of animal communication, human, and environmental sounds allows the documentation of short-term behavioral changes in response to human disturbance. © 2010 Society for Conservation Biology.

Modeling of GCR Environment Variations and Interpretation for Human Explorations

NASA Astrophysics Data System (ADS)

Saganti, Premkumar

We currently have wealth of data with several short duration Space Shuttle (STS) flights to the low earth orbit (LEO) and long duration International Space Station (ISS) expeditions as well as Shuttle-Mir missions over the past few solar cycles. Assessment of such radiation risk is very important particularly for the anticipated long-term and deep-space human explorations. Recently, we have developed a database of first 500 + human explorers and their space travel logs from space exploration missions during the past four decades. Many have traveled into space for only few days while others have been in space for several months. We present the time-line distribution of the space travelers log along with the time correlated radiation en-vironment changes in to aid in the radiation risk assessment for human explorations. These model calculated results and assessment of radiation exposure helps in our understanding of radiation risk and biological consequences.

Space Resource Utilization: Near-Term Missions and Long-Term Plans for Human Exploration

NASA Technical Reports Server (NTRS)

Sanders, Gerald B.

2015-01-01

A primary goal of all major space faring nations is to explore space: from the Earth with telescopes, with robotic probes and space telescopes, and with humans. For the US National Aeronautics and Space Administration (NASA), this pursuit is captured in three important strategic goals: 1. Ascertain the content, origin, and evolution of the solar system and the potential for life elsewhere, 2. Extend and sustain human activities across the solar system (especially the surface of Mars), and 3. Create innovative new space technologies for exploration, science, and economic future. While specific missions and destinations are still being discussed as to what comes first, it is imperative for NASA that it foster the development and implementation of new technologies and approaches that make space exploration affordable and sustainable. Critical to achieving affordable and sustainable human exploration beyond low Earth orbit (LEO) is the development of technologies and systems to identify, extract, and use resources in space instead of bringing everything from Earth. To reduce the development and implementation costs for space resource utilization, often called In Situ Resource Utilization (ISRU), it is imperative to work with terrestrial mining companies to spin-in/spin-off technologies and capabilities, and space mining companies to expand our economy beyond Earth orbit. In the last two years, NASA has focused on developing and implementing a sustainable human space exploration program with the ultimate goal of exploring the surface of Mars with humans. The plan involves developing technology and capability building blocks critical for sustained exploration starting with the Space Launch System (SLS) and Orion crew spacecraft and utilizing the International Space Station as a springboard into the solar system. The evolvable plan develops and expands human exploration in phases starting with missions that are reliant on Earth, to performing ever more challenging and longer duration missions in cis-lunar space and beyond, to eventually being independent from Earth. The goal is no longer just to reach a destination, but to enable people to work, learn, operate, and live safely beyond the Earth for extended periods of time, ultimately in ways that are more sustainable and even indefinite.

The Role of Lunar Development in Human Exploration of the Solar System

NASA Technical Reports Server (NTRS)

Mendell, Wendell W.

1999-01-01

Human exploration of the solar system can be said to have begun with the Apollo landings on the Moon. The Apollo Project was publicly funded with the narrow technical objective of landing human beings on the Moon. The transportation and life support systems were specialized technical designs, developed in a project management environment tailored to that objective. Most scenarios for future human exploration assume a similar long-term commitment of public funds to a narrowly focused project managed by a large, monolithic organization. Advocates of human exploration of space have not yet been successful in generating the political momentum required to initiate such a project to go to the Moon or to Mars. Alternative scenarios of exploration may relax some or all of the parameters of organizational complexity, great expense, narrow technical focus, required public funding, and control by a single organization. Development of the Moon using private investment is quite possibly a necessary condition for alternative scenarios to succeed.

Technology Needs of Future Space Infrastructures Supporting Human Exploration and Development of Space

NASA Technical Reports Server (NTRS)

Carrington, Connie; Howell, Joe

2001-01-01

The path to human presence beyond near-Earth will be paved by the development of infrastructure. A fundamental technology in this infrastructure is energy, which enables not only the basic function of providing shelter for man and machine, but also enables transportation, scientific endeavors, and exploration. This paper discusses the near-term needs in technology that develop the infrastructure for HEDS.

Optimization of System Maturity and Equivalent System Mass for Exploration Systems Development Planning

NASA Technical Reports Server (NTRS)

Magnaye, Romulo; Tan, Weiping; Ramirez-Marquez, Jose; Sauser, Bruce

2010-01-01

The Exploration Systems Mission Directorate of the National Aeronautics and Space Administration (NASA) is currently pursuing the development of the next generation of human spacecraft and exploration systems throughout the Constellation Program. This includes, among others, habitation technologies for supporting lunar and Mars exploration. The key to these systems is the Exploration Life Support (ELS) system that composes several technology development projects related to atmosphere revitalization, water recovery, waste management and habitation. The proper functioning of these technologies is meant to produce sufficient and balanced resources of water, air, and food to maintain a safe and comfortable environment for long-term human habitation and exploration of space.

Cryogenics and the Human Exploration of Mars

NASA Technical Reports Server (NTRS)

Salerno, Louis J.; Kittel, Peter; Rasky, Daniel J. (Technical Monitor)

1997-01-01

Current plans within NASA involve extending the human exploration of space from low earth orbit into the solar system, with the first human exploration of Mars presently planned in 2011. Integral to all hum Mars mission phases is cryogenic fluid management. Cryogenic fluids will be required both as propellant and for In-Situ Resource Utilization (ISRU). Without safe and efficient cryogen storage human Mars missions will not be possible. Effective control and handling of cryogenic fluids is the key to affordable Mars missions, and advancing active thermal control technology is synergistic with all of NASA's exploration initiatives and with existing and future instrument cooling programs, including MTPE and Origins. Present mission scenarios for human exploration require cryogenic propellant storage for up to 1700 days and for up to 60 metric tons. These requirements represent increases of an order of magnitude over previous storage masses and lifetimes. The key cryogenic terminology areas to be addressed in human Mars missions are long-term propellant storage, cryogenic refrigeration, cryogenic liquefaction, and zero gravity fluid management. Long-term storage for the thermal control of cryogenic propellants is best accomplished with a mix of passive and active technologies. Passive technologies such as advanced multilayer insulation (MLI) concepts will be combined with the development of active coolers (cryogenic refrigerators). Candidates for long-life active cooling applications include Reverse Turbo-Brayton, Stirling, and Pulse-Tube coolers. The integration of passive and active technologies will form a hybrid system optimized to minimize the launch mass while preserving the cryogenic propellants. Since cryogenic propellants are the largest mass that Mars missions must launch from earth, even a modest reduction in the percentage of propellant carried results in a significant weight saving. This paper will present a brief overview of cryogenic fluid management technology as it applies to the current human Mars mission scenarios.

ISRU: An Overview of NASA'S Current Development Activities and Long-Term Goals

NASA Technical Reports Server (NTRS)

Sanders, Gerald B.; Nicholson, Leonard S. (Technical Monitor)

2000-01-01

The concept of "living off the land" by utilizing the indigenous resources of the Moon, Mars, or other potential sites of robotic and human exploration has been termed In-Situ Resource Utilization (ISRU). It is fundamental to any program of extended human presence and operation on other extraterrestrial bodies that we learn how to utilize the indigenous resources. The chief benefits of ISRU are that it can reduce the mass, cost, and risk of robotic and human exploration while providing capabilities that enable the commercial development of space. In January 1997, the American Institute of Aeronautics and Astronautics (AIAA) Space Processing Technical Committee released a position paper entitled, "Need for A NASA Indigenous Space Resource Utilization (ISRU) Program". Besides outlining some of the potential advantages of incorporating ISRU into Lunar and Mars human mission plans and providing an overview of technologies and processes of interest, the position paper concluded with a list of seven recommendations to NASA. This paper will examine the seven recommendations proposed and provide an overview of NASA's current ISRU development activities and possible long term goals with respect to these recommendations.

Strategies for Prospecting and Extracting Water on Mars for Long-Term Human Exploration

NASA Astrophysics Data System (ADS)

Rolley, R. J.; Saikia, S. J.

2017-02-01

We aim to develop a specific set of criteria to classify water reserves on Mars, and to design water prospecting and extraction systems for various human landing sites using a requirements-driven framework.

Increased Science Instrumentation Funding Strengthens Mars Program

NASA Technical Reports Server (NTRS)

Graham, Lee D.; Graff, T. G.

2012-01-01

As the strategic knowledge gaps mature for the exploration of Mars, Mars sample return (MSR), and Phobos/Deimos missions, one approach that becomes more probable involves smaller science instrumentation and integrated science suites. Recent technological advances provide the foundation for a significant evolution of instrumentation; however, the funding support is currently too small to fully utilize these advances. We propose that an increase in funding for instrumentation development occur in the near-term so that these foundational technologies can be applied. These instruments would directly address the significant knowledge gaps for humans to Mars orbit, humans to the Martian surface, and humans to Phobos/ Deimos. They would also address the topics covered by the Decadal Survey and the Mars scientific goals, objectives, investigations and priorities as stated by the MEPAG. We argue that an increase of science instrumentation funding would be of great benefit to the Mars program as well as the potential for human exploration of the Mars system. If the total non-Earth-related planetary science instrumentation budget were increased 100% it would not add an appreciable amount to the overall NASA budget and would provide the real potential for future breakthroughs. If such an approach were implemented in the near-term, NASA would benefit greatly in terms of science knowledge of the Mars, Phobos/Deimos system, exploration risk mitigation, technology development, and public interest.

A Vision for the Exploration of Mars: Robotic Precursors Followed by Humans to Mars Orbit in 2033

NASA Technical Reports Server (NTRS)

Sellers, Piers J.; Garvin, James B.; Kinney, Anne L.; Amato, Michael J.; White, Nicholas E.

2012-01-01

The reformulation of the Mars program gives NASA a rare opportunity to deliver a credible vision in which humans, robots, and advancements in information technology combine to open the deep space frontier to Mars. There is a broad challenge in the reformulation of the Mars exploration program that truly sets the stage for: 'a strategic collaboration between the Science Mission Directorate (SMD), the Human Exploration and Operations Mission Directorate (HEOMD) and the Office of the Chief Technologist, for the next several decades of exploring Mars'.Any strategy that links all three challenge areas listed into a true long term strategic program necessitates discussion. NASA's SMD and HEOMD should accept the President's challenge and vision by developing an integrated program that will enable a human expedition to Mars orbit in 2033 with the goal of returning samples suitable for addressing the question of whether life exists or ever existed on Mars

The potential of space exploration for the fine arts

NASA Technical Reports Server (NTRS)

Mclaughlin, William I.

1993-01-01

Art provides an integrating function between the 'upper' and 'lower' centers of the human psyche. The nature of this function can be made more specific through the triune model of the brain. The evolution of the fine arts - painting, drawing, architecture, sculpture, literature, music, dance, and drama, plus cinema and mathematics-as-a-fine-art - are examined in the context of their probable stimulations by space exploration: near term and long term.

Approach and Issues Relating to Shield Material Design to Protect Astronauts from Space Radiation

NASA Technical Reports Server (NTRS)

Wilson, J. W.; Cucinotta, F. A.; Miller, J.; Shinn, J. L.; Thibeault, S. A.; Singleterry, R. C.; Simonsen, L. C.; Kim, M. H.

2001-01-01

One major obstacle to human space exploration is the possible limitations imposed by the adverse effects of long-term exposure to the space environment. Even before human spaceflight began, the potentially brief exposure of astronauts to the very intense random solar energetic particle (SEP) events was of great concern. A new challenge appears in deep space exploration from exposure to the low-intensity heavy-ion flux of the galactic cosmic rays (GCR) since the missions are of long duration and the accumulated exposures can be high. Since aluminum (traditionally used in spacecraft to avoid potential radiation risks) leads to prohibitively expensive mission launch costs, alternative materials need to be explored. An overview of the materials related issues and their impact on human space exploration will be given.

Advanced Solid State Lighting for Human Evaluation Project

NASA Technical Reports Server (NTRS)

Zeitlin, Nancy; Holbert, Eirik

2015-01-01

Lighting intensity and color have a significant impact on human circadian rhythms. Advanced solid state lighting was developed for the Advanced Exploration System (AES) Deep Space Habitat(DSH) concept demonstrator. The latest generation of assemblies using the latest commercially available LED lights were designed for use in the Bigelow Aerospace Environmental Control and Life Support System (ECLSS) simulator and the University of Hawaii's Hawaii Space Exploration Analog and Simulation (Hi-SEAS) habitat. Agreements with both these organizations will allow the government to receive feedback on the lights and lighting algorithms from long term human interaction.

Determine Important Nuclear Fragmentation Processes for Space Radiation Protection in Human Space Explorations

NASA Technical Reports Server (NTRS)

Lin, Zi-wei

2004-01-01

Space radiation from cosmic ray particles is one of the main challenges for long-term human space explorations such as a permanent moon base or a trip to Mars. Material shielding may provide significant radiation protection to astronauts, and models have been developed in order to evaluate the effectiveness of different shielding materials and to predict radiation environment inside the spacecraft. In this study we determine the nuclear fragmentation cross sections which will most effect the radiation risk behind typical radiation shielding materials. These cross sections thus need more theoretical studies and accurate experimental measurements in order for us to more precisely predict the radiation risk in human space explorations.

Determine Important Nuclear Fragmentation Processes for Space Radiation Protection in Human Space Explorations

NASA Technical Reports Server (NTRS)

Lin, Zi-Wei

2004-01-01

Space radiation from cosmic ray particles is one of the main challenges for long-term human space explorations such as a permanent moon base or a trip to Mars. Material shielding may provide significant radiation protection to astronauts, and models have been developed in order to evaluate the effectiveness of different shielding materials and to predict radiation environment inside the spacecraft. In this study we determine the nuclear fragmentation cross sections which will most affect the radiation risk behind typical radiation shielding materials. These cross sections thus need more theoretical studies and accurate experimental measurements in order for us to more precisely predict the radiation risk in human space exploration.

Determine Important Nuclear Fragmentation Processes for Space Radiation Protection in Human Space Explorations

NASA Technical Reports Server (NTRS)

Lin, Zi-Wei

2004-01-01

Space radiation from cosmic ray particles is one of the main challenges for long-term human space explorations such as a permanent moon base or a trip to Mars. Material shielding may provide significant radiation protection to astronauts, and models have been developed in order to evaluate the effectiveness of different shielding materials and to predict radiation environment inside the spacecraft. In this study we determine the nuclear fragmentation cross sections which will most affect the radiation risk behind typical radiation shielding materials. These cross sections thus need more theoretical studies and accurate experimental measurements in order for us to more precisely predict the radiation risk in human space explorations.

Mars scientific investigations as a precursor for human exploration.

PubMed

Ahlf, P; Cantwell, E; Ostrach, L; Pline, A

2000-01-01

In the past two years, NASA has begun to develop and implement plans for investigations on robotic Mars missions which are focused toward returning data critical for planning human missions to Mars. The Mars Surveyor Program 2001 Orbiter and Lander missions will mark the first time that experiments dedicated to preparation for human exploration will be carried out. Investigations on these missions and future missions range from characterization of the physical and chemical environment of Mars, to predicting the response of biology to the Mars environment. Planning for such missions must take into account existing data from previous Mars missions which were not necessarily focused on human exploration preparation. At the same time, plans for near term missions by the international community must be considered to avoid duplication of effort. This paper reviews data requirements for human exploration and applicability of existing data. It will also describe current plans for investigations and place them within the context of related international activities. c 2000 International Astronautical Federation. Published by Elsevier Science Ltd. All rights reserved.

Mars scientific investigations as a precursor for human exploration

NASA Technical Reports Server (NTRS)

Ahlf, P.; Cantwell, E.; Ostrach, L.; Pline, A.

2000-01-01

In the past two years, NASA has begun to develop and implement plans for investigations on robotic Mars missions which are focused toward returning data critical for planning human missions to Mars. The Mars Surveyor Program 2001 Orbiter and Lander missions will mark the first time that experiments dedicated to preparation for human exploration will be carried out. Investigations on these missions and future missions range from characterization of the physical and chemical environment of Mars, to predicting the response of biology to the Mars environment. Planning for such missions must take into account existing data from previous Mars missions which were not necessarily focused on human exploration preparation. At the same time, plans for near term missions by the international community must be considered to avoid duplication of effort. This paper reviews data requirements for human exploration and applicability of existing data. It will also describe current plans for investigations and place them within the context of related international activities. c 2000 International Astronautical Federation. Published by Elsevier Science Ltd. All rights reserved.

Human Mars Mission Overview and Dust Storm Impacts on Site Selection

NASA Technical Reports Server (NTRS)

Hoffman, S. J.

2017-01-01

NASA has begun a process to identify and discuss candidate locations where humans could land, live and work on the martian surface. This process is being carried out as a cooperative effort by NASA's Human Exploration and Operations Mission Directorate (HEOMD), responsible for future human mission preparations, and the Science Mission Directorate (SMD), responsible for the on-going Mars Exploration Program of robotic vehicles in orbit and on the surface of Mars. Both of these Directorates have a significant interest in this process, as these candidate locations will be used by NASA as part of a multi-year effort to determine where and how humans could explore Mars. In the near term this process includes: (a) identifying locations that would maximize the potential science return from future human exploration missions, (b) identifying locations with the potential for resources required to support humans, (c) developing concepts and engineering systems needed by future human crews to conduct operations within a candidate location, and (d) identifying key characteristics of the proposed candidate locations that cannot be evaluated using existing data sets, thus helping to define precursor measurements needed in advance of human missions.

The Dimensionality and Correlates of Flow in Human-Computer Interactions.

ERIC Educational Resources Information Center

Webster, Jane; And Others

1993-01-01

Defines playfulness in human-computer interactions in terms of flow theory and explores the dimensionality of the flow concept. Two studies are reported that investigated the factor structure and correlates of flow in human-computer interactions: one examined MBA students using Lotus 1-2-3 spreadsheet software, and one examined employees using…

Integrated Human-Robotic Missions to the Moon and Mars: Mission Operations Design Implications

NASA Technical Reports Server (NTRS)

Mishkin, Andrew; Lee, Young; Korth, David; LeBlanc, Troy

2007-01-01

For most of the history of space exploration, human and robotic programs have been independent, and have responded to distinct requirements. The NASA Vision for Space Exploration calls for the return of humans to the Moon, and the eventual human exploration of Mars; the complexity of this range of missions will require an unprecedented use of automation and robotics in support of human crews. The challenges of human Mars missions, including roundtrip communications time delays of 6 to 40 minutes, interplanetary transit times of many months, and the need to manage lifecycle costs, will require the evolution of a new mission operations paradigm far less dependent on real-time monitoring and response by an Earthbound operations team. Robotic systems and automation will augment human capability, increase human safety by providing means to perform many tasks without requiring immediate human presence, and enable the transfer of traditional mission control tasks from the ground to crews. Developing and validating the new paradigm and its associated infrastructure may place requirements on operations design for nearer-term lunar missions. The authors, representing both the human and robotic mission operations communities, assess human lunar and Mars mission challenges, and consider how human-robot operations may be integrated to enable efficient joint operations, with the eventual emergence of a unified exploration operations culture.

Integrated Human-Robotic Missions to the Moon and Mars: Mission Operations Design Implications

NASA Technical Reports Server (NTRS)

Korth, David; LeBlanc, Troy; Mishkin, Andrew; Lee, Young

2006-01-01

For most of the history of space exploration, human and robotic programs have been independent, and have responded to distinct requirements. The NASA Vision for Space Exploration calls for the return of humans to the Moon, and the eventual human exploration of Mars; the complexity of this range of missions will require an unprecedented use of automation and robotics in support of human crews. The challenges of human Mars missions, including roundtrip communications time delays of 6 to 40 minutes, interplanetary transit times of many months, and the need to manage lifecycle costs, will require the evolution of a new mission operations paradigm far less dependent on real-time monitoring and response by an Earthbound operations team. Robotic systems and automation will augment human capability, increase human safety by providing means to perform many tasks without requiring immediate human presence, and enable the transfer of traditional mission control tasks from the ground to crews. Developing and validating the new paradigm and its associated infrastructure may place requirements on operations design for nearer-term lunar missions. The authors, representing both the human and robotic mission operations communities, assess human lunar and Mars mission challenges, and consider how human-robot operations may be integrated to enable efficient joint operations, with the eventual emergence of a unified exploration operations culture.

Space Exploration: Challenges in Medicine, Research, and Ethics

NASA Technical Reports Server (NTRS)

Davis, Jeffrey R.

2007-01-01

This viewgraph presentation describes the challenges that space exploration faces in terms of medicine, research and ethics. The topics include: 1) Effects of Microgravity on Human Physiology; 2) Radiation; 3) Bone; 4) Behavior and Performance; 5) Muscle; 6) Cardiovascular; 7) Neurovestibular; 8) Food and Nutrition; 9) Immunology and Hematology; 10) Environment; 11) Exploration; 12) Building Block Approach; 13) Exploration Issues; 14) Life Sciences Contributions; 15) Health Care; and 17) Habitability.

NASA's Decadal Planning Team Mars Mission Analysis Summary

NASA Astrophysics Data System (ADS)

Drake, Bret G.

2007-02-01

In June 1999 the NASA Administrator chartered an internal NASA task force, termed the Decadal Planning Team, to create new integrated vision and strategy for space exploration. The efforts of the Decadal Planning Team evolved into the Agency-wide team known as the NASA Exploration Team (NEXT). This team was also instructed to identify technology roadmaps to enable the science-driven exploration vision, established a cross-Enterprise, cross-Center systems engineering team with emphasis focused on revolutionary not evolutionary approaches. The strategy of the DPT and NEXT teams was to "Go Anywhere, Anytime" by conquering key exploration hurdles of space transportation, crew health and safety, human/robotic partnerships, affordable abundant power, and advanced space systems performance. Early emphasis was placed on revolutionary exploration concepts such as rail gun and electromagnetic launchers, propellant depots, retrograde trajectories, nano structures, and gas core nuclear rockets to name a few. Many of these revolutionary concepts turned out to be either not feasible for human exploration missions or well beyond expected technology readiness for near-term implementation. During the DPT and NEXT study cycles, several architectures were analyzed including missions to the Earth-Sun Libration Point (L2), the Earth-Moon Gateway and L1, the lunar surface, Mars (both short and long stays), one-year round trip Mars, and near-Earth asteroids. Common emphasis of these studies included utilization of the Earth-Moon Libration Point (L1) as a staging point for exploration activities, current (Shuttle) and near-term launch capabilities (EELV), advanced propulsion, and robust space power. Although there was much emphasis placed on utilization of existing launch capabilities, the team concluded that missions in near-Earth space are only marginally feasible and human missions to Mars were not feasible without a heavy lift launch capability. In addition, the team concluded that missions in Earth s neighborhood, such as to the Moon, can serve as stepping-stones toward further deep-space missions in terms of proving systems, technologies, and operational concepts. The material contained in this presentation was compiled to capture the work performed by the Mars Sub-Team of the DPT NEXT efforts in the late 1999-2001 timeframe.

NASA's Decadal Planning Team Mars Mission Analysis Summary

NASA Technical Reports Server (NTRS)

Drake, Bret G. (Editor)

2007-01-01

In June 1999 the NASA Administrator chartered an internal NASA task force, termed the Decadal Planning Team, to create new integrated vision and strategy for space exploration. The efforts of the Decadal Planning Team evolved into the Agency-wide team known as the NASA Exploration Team (NEXT). This team was also instructed to identify technology roadmaps to enable the science-driven exploration vision, established a cross-Enterprise, cross-Center systems engineering team with emphasis focused on revolutionary not evolutionary approaches. The strategy of the DPT and NEXT teams was to "Go Anywhere, Anytime" by conquering key exploration hurdles of space transportation, crew health and safety, human/robotic partnerships, affordable abundant power, and advanced space systems performance. Early emphasis was placed on revolutionary exploration concepts such as rail gun and electromagnetic launchers, propellant depots, retrograde trajectories, nano structures, and gas core nuclear rockets to name a few. Many of these revolutionary concepts turned out to be either not feasible for human exploration missions or well beyond expected technology readiness for near-term implementation. During the DPT and NEXT study cycles, several architectures were analyzed including missions to the Earth-Sun Libration Point (L2), the Earth-Moon Gateway and L1, the lunar surface, Mars (both short and long stays), one-year round trip Mars, and near-Earth asteroids. Common emphasis of these studies included utilization of the Earth-Moon Libration Point (L1) as a staging point for exploration activities, current (Shuttle) and near-term launch capabilities (EELV), advanced propulsion, and robust space power. Although there was much emphasis placed on utilization of existing launch capabilities, the team concluded that missions in near-Earth space are only marginally feasible and human missions to Mars were not feasible without a heavy lift launch capability. In addition, the team concluded that missions in Earth s neighborhood, such as to the Moon, can serve as stepping-stones toward further deep-space missions in terms of proving systems, technologies, and operational concepts. The material contained in this presentation was compiled to capture the work performed by the Mars Sub-Team of the DPT NEXT efforts in the late 1999-2001 timeframe.

Sustained Innovation Through Shared Capitalism and Democratic Governance

NASA Astrophysics Data System (ADS)

Beyster, M. A.; Blasi, J.; Sibilia, J.; Zebuchen, T.; Bowman, A.

The Foundation for Enterprise Development (FED) explores application of democratic representative governance models and structures for long-term interdisciplinary research, development and education to the concept of an organization that can sustain activity in support of interstellar travel in the 100-year timeframe, as outlined by the 100 Year StarshipTM. This paper titled, Sustained Innovation through Shared Capitalism and Democratic Governance , explores the roots of representative structures and organizations as long-lived success stories throughout history. Research, innovation, organizational structures and associated issues are explored to address the long-term focus required for development, both material and human. Impact investing vehicles are also explored as potential investment structures addressing the long-term horizon required by the organization. This paper provides an illustration, description and philosophical approach of this model as developed by the FED and our collaborators.

An alternative approach to solar system exploration providing safety of human mission to Mars.

PubMed

Gitelson, J I; Bartsev, S I; Mezhevikin, V V; Okhonin, V A

2003-01-01

For systematic human Mars exploration, meeting crew safety requirements, it seems perspective to assemble into a spacecraft: an electrical rocket, a well-shielded long-term life support system, and a manipulator-robots operating in combined "presence effect" and "master-slave" mode. The electrical spacecraft would carry humans to the orbit of Mars, providing short distance (and low signal time delay) between operator and robot-manipulators, which are landed on the surface of the planet. Long-term hybrid biological and physical/chemical LSS could provide environment supporting human health and well being. Robot-manipulators operating in "presence effect" and "master-slave" mode exclude necessity of human landing on Martian surface decreasing the level of risk for crew. Since crewmen would not have direct contact with the Martian environment then the problem of mutual biological protection is essentially reduced. Lightweight robot-manipulators, without heavy life support systems and without the necessity of returning to the mother vessel, could be sent as scouts to different places on the planet surface, scanning the most interesting for exobiological research site. Some approximate estimations of electric spacecraft, long-term hybrid LSS, radiation protection and mission parameters are conducted and discussed. c2002 COSPAR. Published by Elsevier Science Ltd. All rights reserved.

DES-ncRNA: A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining.

PubMed

Salhi, Adil; Essack, Magbubah; Alam, Tanvir; Bajic, Vladan P; Ma, Lina; Radovanovic, Aleksandar; Marchand, Benoit; Schmeier, Sebastian; Zhang, Zhang; Bajic, Vladimir B

2017-07-03

Noncoding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long ncRNAs (lncRNAs), are important players in diseases and emerge as novel drug targets. Thus, unraveling the relationships between ncRNAs and other biomedical entities in cells are critical for better understanding ncRNA roles that may eventually help develop their use in medicine. To support ncRNA research and facilitate retrieval of relevant information regarding miRNAs and lncRNAs from the plethora of published ncRNA-related research, we developed DES-ncRNA ( www.cbrc.kaust.edu.sa/des_ncrna ). DES-ncRNA is a knowledgebase containing text- and data-mined information from public scientific literature and other public resources. Exploration of mined information is enabled through terms and pairs of terms from 19 topic-specific dictionaries including, for example, antibiotics, toxins, drugs, enzymes, mutations, pathways, human genes and proteins, drug indications and side effects, mutations, diseases, etc. DES-ncRNA contains approximately 878,000 associations of terms from these dictionaries of which 36,222 (5,373) are with regards to miRNAs (lncRNAs). We provide several ways to explore information regarding ncRNAs to users including controlled generation of association networks as well as hypotheses generation. We show an example how DES-ncRNA can aid research on Alzheimer disease and suggest potential therapeutic role for Fasudil. DES-ncRNA is a powerful tool that can be used on its own or as a complement to the existing resources, to support research in human ncRNA. To our knowledge, this is the only knowledgebase dedicated to human miRNAs and lncRNAs derived primarily through literature-mining enabling exploration of a broad spectrum of associated biomedical entities, not paralleled by any other resource.

DES-ncRNA: A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining

PubMed Central

Salhi, Adil; Essack, Magbubah; Alam, Tanvir; Bajic, Vladan P.; Ma, Lina; Radovanovic, Aleksandar; Marchand, Benoit; Zhang, Zhang; Bajic, Vladimir B.

2017-01-01

ABSTRACT Noncoding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long ncRNAs (lncRNAs), are important players in diseases and emerge as novel drug targets. Thus, unraveling the relationships between ncRNAs and other biomedical entities in cells are critical for better understanding ncRNA roles that may eventually help develop their use in medicine. To support ncRNA research and facilitate retrieval of relevant information regarding miRNAs and lncRNAs from the plethora of published ncRNA-related research, we developed DES-ncRNA (www.cbrc.kaust.edu.sa/des_ncrna). DES-ncRNA is a knowledgebase containing text- and data-mined information from public scientific literature and other public resources. Exploration of mined information is enabled through terms and pairs of terms from 19 topic-specific dictionaries including, for example, antibiotics, toxins, drugs, enzymes, mutations, pathways, human genes and proteins, drug indications and side effects, mutations, diseases, etc. DES-ncRNA contains approximately 878,000 associations of terms from these dictionaries of which 36,222 (5,373) are with regards to miRNAs (lncRNAs). We provide several ways to explore information regarding ncRNAs to users including controlled generation of association networks as well as hypotheses generation. We show an example how DES-ncRNA can aid research on Alzheimer disease and suggest potential therapeutic role for Fasudil. DES-ncRNA is a powerful tool that can be used on its own or as a complement to the existing resources, to support research in human ncRNA. To our knowledge, this is the only knowledgebase dedicated to human miRNAs and lncRNAs derived primarily through literature-mining enabling exploration of a broad spectrum of associated biomedical entities, not paralleled by any other resource. PMID:28387604

Conceptual Distinctiveness Supports Detailed Visual Long-Term Memory for Real-World Objects

ERIC Educational Resources Information Center

Konkle, Talia; Brady, Timothy F.; Alvarez, George A.; Oliva, Aude

2010-01-01

Humans have a massive capacity to store detailed information in visual long-term memory. The present studies explored the fidelity of these visual long-term memory representations and examined how conceptual and perceptual features of object categories support this capacity. Observers viewed 2,800 object images with a different number of exemplars…

The Concept and Experimental Investigation of CO2 and Steam Co-electrolysis for Resource Utilization in Space Exploration

NASA Technical Reports Server (NTRS)

Stoots, Carl; Mulloth, Lila M.; Luna, Bernadette; Varghese, Mini M.

2009-01-01

CO2 acquisition and utilization technologies will have a vital role in determining sustained and affordable life support and in-situ fuel production architectures for human and robotic exploration of Moon and Mars. For long-term human exploration to be practical, reliable technologies have to be implemented to capture and chemically reduce the metabolic CO2 from the cabin air to restitute oxygen consumption. Technologies that facilitate the in-situ capture and conversion of atmospheric CO2 to fuel are essential for a viable human mission to Mars and their demonstration on the moon is critical as well. This paper describes the concept and experimental investigation of a CO2 capture and reduction system that comprises an adsorption compressor and a CO2 and steam co-electrolysis unit. The process products include oxygen for life support and Syngas (CO and H2) for synthetic fuel production. Electrochemical performance in terms of CO2 conversion, oxygen production, and power consumption of a system with a capacity to process 1kg CO2 per day (1-person equivalent) will be discussed.

Futures of Human Communication.

ERIC Educational Resources Information Center

Harms, L. S.

There are several research areas basic to the long-range future of human communications. Telecommunication and transportation offer the possiblity of two worldwide communications networks whose interrelationships need to be explored in terms of the needs of the individual, the community, and the world at large. Expanding possibilities of…

Haptic Classification of Common Objects: Knowledge-Driven Exploration.

ERIC Educational Resources Information Center

Lederman, Susan J.; Klatzky, Roberta L.

1990-01-01

Theoretical and empirical issues relating to haptic exploration and the representation of common objects during haptic classification were investigated in 3 experiments involving a total of 112 college students. Results are discussed in terms of a computational model of human haptic object classification with implications for dextrous robot…

An Antarctic research outpost as a model for planetary exploration.

PubMed

Andersen, D T; McKay, C P; Wharton, R A; Rummel, J D

1990-01-01

During the next 50 years, human civilization may well begin expanding into the solar system. This colonization of extraterrestrial bodies will most likely begin with the establishment of small research outposts on the Moon and/or Mars. In all probability these facilities, designed primarily for conducting exploration and basic science, will have international participation in their crews, logistical support and funding. High fidelity Earth-based simulations of planetary exploration could help prepare for these expensive and complex operations. Antarctica provides one possible venue for such a simulation. The hostile and remote dry valleys of southern Victoria Land offer a valid analog to the Martian environment but are sufficiently accessible to allow routine logistical support and to assure the relative safety of their inhabitants. An Antarctic research outpost designed as a planetary exploration simulation facility would have great potential as a testbed and training site for the operation of future Mars bases and represents a near-term, relatively low-cost alternative to other precursor activities. Antarctica already enjoys an international dimension, an aspect that is more than symbolically appropriate to an international endeavor of unprecedented scientific and social significance--planetary exploration by humans. Potential uses of such a facility include: 1) studying human factors in an isolated environment (including long-term interactions among an international crew); 2) testing emerging technologies (e.g., advanced life support facilities such as a partial bioregenerative life support system, advanced analytical and sample acquisition instrumentation and equipment, etc.); and 3) conducting basic scientific research similar to the research that will be conducted on Mars, while contributing to the planning for human exploration. (Research of this type is already ongoing in Antarctica).

Starting a European Space Agency Sample Analogue Collection (ESA2C) and Curation Facility for Exploration Missions.

NASA Astrophysics Data System (ADS)

Smith, C. L.; Rumsey, M. S.; Manick, K.; Gill, S.-J.; Mavris, C.; Schroeven-Deceuninck, H.; Duvet, L.

2017-09-01

The ESA2C will support current and future technology development activities that are required for human and robotic exploration of Mars, Phobos, Deimos, C-Type Asteroids and the Moon.The long-term goal of this work is to produce a useful, useable and sustainable resource for engineers and scientists developing technologies for ESA space exploration missions.

Pastoral hermeneutics and the challenge of a global economy: care to the living human Web.

PubMed

Louw, D J

2002-01-01

The author discusses the relationship between a pastoral hermeneutics and the current social context as determined by international communication and globalization. He explores the influence of telecommunications on the human quest for meaning and the implication of this for pastoral care and counseling. A paradigm shift is proposed in terms of care to the living human web. A pastoral assessment which interprets the undergirding philosophy and belief system of globalization and its influence on human dignity is suggested; and a pastoral ministry which takes up its prophetic task and voices the needs of people in terms of a "globalization from below" is explicated.

Blue Marble Space Institute essay contest

NASA Astrophysics Data System (ADS)

Wendel, JoAnna

2014-04-01

The Blue Marble Space Institute of Science, based in Seattle, Wash., is inviting college students to participate in its essay contest. Essays need to address the question, "In the next 100 years, how can human civilization prepare for the long-term changes to the Earth system that will occur over the coming millennium?" According to the institute, the purpose of the contest is "to stimulate creative thinking relating to space exploration and global issues by exploring how changes in the Earth system will affect humanity's future."

Working Group Reports and Presentations: Mars Settlement and Society

NASA Technical Reports Server (NTRS)

McKay, Chris

2006-01-01

The long-term implications of space exploration must be considered early in the process. With this in mind, the Mars Settlement and Society Group focused on five key areas: Philosophical Framework, Community Infrastructure and Government, Creating Stakeholders, Human Subsystems, and Habitat Design. The team proposes long and short term goals to support getting to and then staying long-term on Mars. All objectives shared the theme that they should engage, inspire, and educate the public with the intent of fostering stakeholders in the exploration of Mars. The objectives of long-term settlement on Mars should not neglect group dynamics, issues of reproduction, and a strong philosophical framework for the establishment of a society.

Human Exploration Framework Team: Strategy and Status

NASA Technical Reports Server (NTRS)

Muirhead, Brian K.; Sherwood, Brent; Olson, John

2011-01-01

Human Exploration Framework Team (HEFT) was formulated to create a decision framework for human space exploration that drives out the knowledge, capabilities and infrastructure NASA needs to send people to explore multiple destinations in the Solar System in an efficient, sustainable way. The specific goal is to generate an initial architecture that can evolve into a long term, enterprise-wide architecture that is the basis for a robust human space flight enterprise. This paper will discuss the initial HEFT activity which focused on starting up the cross-agency team, getting it functioning, developing a comprehensive development and analysis process and conducting multiple iterations of the process. The outcome of this process will be discussed including initial analysis of capabilities and missions for at least two decades, keeping Mars as the ultimate destination. Details are provided on strategies that span a broad technical and programmatic trade space, are analyzed against design reference missions and evaluated against a broad set of figures of merit including affordability, operational complexity, and technical and programmatic risk.

Early Extinction after Fear Conditioning Yields a Context-Independent and Short-Term Suppression of Conditional Freezing in Rats

ERIC Educational Resources Information Center

Chang, Chun-hui; Maren, Stephen

2009-01-01

Extinction of Pavlovian fear conditioning in rats is a useful model for therapeutic interventions in humans with anxiety disorders. Recently, we found that delivering extinction trials soon (15 min) after fear conditioning yields a short-term suppression of fear, but little long-term extinction. Here, we explored the possible mechanisms underlying…

PHOBOS Exploration using Two Small Solar Electric Propulsion Spacecraft

NASA Technical Reports Server (NTRS)

Lang, Jared J.; Baker, John D.; Castillo-Rogez, Julie C.; McElrath, Timothy P.; Piacentine, Jamie S.; Snyder, J. Steve

2012-01-01

Primitive bodies are exciting targets for exploration as they provide clues to the early Solar system conditions and dynamical evolution. The two moons of Mars are particularly interesting because of their proximity to an astrobiological target. However, after four decades of Mars exploration, their origin and nature remain enigmatic. In addition, when considering the long-term objectives of the flexible path for the potential human exploration to Mars, Phobos and Deimos present exciting intermediate opportunities without the complication and expense of landing and ascending from the surface. As interest in these targets for the next frontier of human exploration grows, characterization missions designed specifically to examine surface properties, landing environments, and surface mapping prior to human exploration are becoming increasingly important. A precursor mission concept of this sort has been developed using two identical spacecraft designed from low cost, flight proven and certified off-the-shelf component and utilizing Solar Electric Propulsion (SEP) to orbit both targets as secondary payloads launched aboard any NASA or GTO launch. This precursor mission has the potential to address both precursor measurements that are strategic knowledge gaps and decadal science, including soil physical properties at the global and local (human) scale and the search for in situ resources.

Visuals and Visualisation of Human Body Systems

ERIC Educational Resources Information Center

Mathai, Sindhu; Ramadas, Jayashree

2009-01-01

This paper explores the role of diagrams and text in middle school students' understanding and visualisation of human body systems. We develop a common framework based on structure and function to assess students' responses across diagram and verbal modes. Visualisation is defined in terms of understanding transformations on structure and relating…

Mars Design Reference Architecture 5.0 Study: Executive Summary

NASA Technical Reports Server (NTRS)

Drake, Bret G.

2008-01-01

The NASA Mars Design Reference Architecture 5.0 Study seeks to update its long term goals and objective for human exploration missions; flight and surface systems for human missions and supporting infrastructure; operational concept for human and robotic exploration of Mars; key challenges including risk and cost drivers; and, its development schedule options. It additionally seeks to assess strategic linkages between lunar and Mars strategies and develop and understanding of methods for reducing the cost/risk of human Mars missions through investment in research, technology development, and synergy with other exploration plans. Recommendations are made regarding conjunction class (long-stay) missions which are seen as providing the best balance of cost, risk, and performance. Additionally, this study reviews entry, descent, and landing challenges; in-space transportation systems; launch vehicle and Orion assessments; risk and risk mitigation; key driving requirements and challenges; and, lunar linkages.

From LEO, to the Moon and then Mars: Developing a Global Strategy for Exploration Risk Reduction

NASA Technical Reports Server (NTRS)

Laurini, Kathleen C.; Hufenbach, Bernard

2009-01-01

Most nations currently involved in human spaceflight, or with such ambitions, believe that space exploration will capture the imagination of our youth resulting in future engineers and scientists, advance technologies which will improve life on earth, increase the knowledge of our solar system, and strengthen bonds and relationships across the globe. The Global Exploration Strategy, published in 2007 by 14 space agencies, eloquently makes this case and presents a vision for space exploration. It argues that in order for space exploration to be sustainable, nations must work together to address the challenges and share the burden of costs. This paper will examine Mars mission scenarios developed by NASA, ESA and other agencies and show resulting conclusions regarding key challenges, needed technologies and associated mission risks. It will discuss the importance of using the International Space Station as a platform for exploration risk reduction and how the global exploration community will develop lunar exploration elements and architectures that enable the long term goal of human missions to Mars. The International Space Station (ISS) is a critical first step both from a technology and capability demonstration point of view, but also from a partnership point of view. There is much work that can be done in low earth orbit for exploration risk reduction. As the current "outpost at the edge of the frontier", the ISS is a place where we can demonstrate certain technologies and capabilities that will substantially reduce the risk of deploying an outpost on the lunar surface and Mars mission scenarios. The ISS partnership is strong and has fulfilled mission needs. Likewise, the partnerships we build on the moon will provide a strong foundation for establishing partnerships for the human Mars missions. On the moon, we build a permanently manned outpost and deploy technologies and capabilities to allow humans to stay for long periods of time. The moon is interesting from a scientific point of view, but it is extremely important for development and demonstration the technologies and capabilities needed for human missions to Mars. This paper will show the logic and strategy for addressing technological, operational and programmatic challenges by using low earth orbit and lunar missions to enable the long term goal of exploration of our solar system.

The Concept and Analytical Investigation of CO2 and Steam Co-Electrolysis for Resource Utilization in Space Exploration

NASA Technical Reports Server (NTRS)

McKellar, Michael G.; Stoots, Carl M.; Sohal, Manohar S.; Mulloth, Lila M.; Luna, Bernadette; Abney, Morgan B.

2010-01-01

CO2 acquisition and utilization technologies will have a vital role in designing sustainable and affordable life support and in situ fuel production architectures for human and robotic exploration of Moon and Mars. For long-term human exploration to be practical, reliable technologies have to be implemented to capture the metabolic CO2 from the cabin air and chemically reduce it to recover oxygen. Technologies that enable the in situ capture and conversion of atmospheric CO2 to fuel are essential for a viable human mission to Mars. This paper describes the concept and mathematical analysis of a closed-loop life support system based on combined electrolysis of CO2 and steam (co-electrolysis). Products of the coelectrolysis process include oxygen and syngas (CO and H2) that are suitable for life support and synthetic fuel production, respectively. The model was developed based on the performance of a co-electrolysis system developed at Idaho National Laboratory (INL). Individual and combined process models of the co-electrolysis and Sabatier, Bosch, Boudouard, and hydrogenation reactions are discussed and their performance analyses in terms of oxygen production and CO2 utilization are presented.

Materials for Shielding Astronauts from the Hazards of Space Radiations

NASA Technical Reports Server (NTRS)

Wilson, J. W.; Cucinotta, F. A.; Miller, J.; Shinn, J. L.; Thibeault, S. A.; Singleterry, R. C.; Simonsen, L. C.; Kim, M. H.

1997-01-01

One major obstacle to human space exploration is the possible limitations imposed by the adverse effects of long-term exposure to the space environment. Even before human spaceflight began, the potentially brief exposure of astronauts to the very intense random solar energetic particle (SEP) events was of great concern. A new challenge appears in deep space exploration from exposure to the low-intensity heavy-ion flux of the galactic cosmic rays (GCR) since the missions are of long duration and the accumulated exposures can be high. Because cancer induction rates increase behind low to rather large thickness of aluminum shielding according to available biological data on mammalian exposures to GCR like ions, the shield requirements for a Mars mission are prohibitively expensive in terms of mission launch costs. Preliminary studies indicate that materials with high hydrogen content and low atomic number constituents are most efficient in protecting the astronauts. This occurs for two reasons: the hydrogen is efficient in breaking up the heavy GCR ions into smaller less damaging fragments and the light constituents produce few secondary radiations (especially few biologically damaging neutrons). An overview of the materials related issues and their impact on human space exploration will be given.

Clinical Outcome Metrics for Optimization of Robust Training

NASA Technical Reports Server (NTRS)

Ebert, D.; Byrne, V. E.; McGuire, K. M.; Hurst, V. W., IV; Kerstman, E. L.; Cole, R. W.; Sargsyan, A. E.; Garcia, K. M,; Foy, M. H.; Dulchavsky, S. A.;

HERRO Mission to Mars Using Telerobotic Surface Exploration from Orbit

NASA Technical Reports Server (NTRS)

Oleson, Steven R.; Landis, Geoffrey A.; McGuire, Melissa L.; Schmidt, George R.

2013-01-01

This paper presents a concept for a human mission to Mars orbit that features direct robotic exploration of the planet s surface via teleoperation from orbit. This mission is a good example of Human Exploration using Real-time Robotic Operations (HERRO), an exploration strategy that refrains from sending humans to the surfaces of planets with large gravity wells. HERRO avoids the need for complex and expensive man-rated lander/ascent vehicles and surface systems. Additionally, the humans are close enough to the surface to effectively eliminate the two-way communication latency that constrains typical robotic space missions, thus allowing real-time command and control of surface operations and experiments by the crew. Through use of state-of-the-art telecommunications and robotics, HERRO provides the cognitive and decision-making advantages of having humans at the site of study for only a fraction of the cost of conventional human surface missions. It is very similar to how oceanographers and oil companies use telerobotic submersibles to work in inaccessible areas of the ocean, and represents a more expedient, near-term step prior to landing humans on Mars and other large planetary bodies. Results suggest that a single HERRO mission with six crew members could achieve the same exploratory and scientific return as three conventional crewed missions to the Mars surface.

A Sustainable Architecture for Lunar Resource Prospecting from an EML-based Exploration Platform

NASA Astrophysics Data System (ADS)

Klaus, K.; Post, K.; Lawrence, S. J.

2012-12-01

Introduction - We present a point of departure architecture for prospecting for Lunar Resources from an Exploration Platform at the Earth - Moon Lagrange points. Included in our study are launch vehicle, cis-lunar transportation architecture, habitat requirements and utilization, lander/rover concepts and sample return. Different transfer design techniques can be explored by mission designers, testing various propulsive systems, maneuvers, rendezvous, and other in-space and surface operations. Understanding the availability of high and low energy trajectory transfer options opens up the possibility of exploring the human and logistics support mission design space and deriving solutions never before contemplated. For sample return missions from the lunar surface, low-energy transfers could be utilized between EML platform and the surface as well as return of samples to EML-based spacecraft. Human Habitation at the Exploration Platform - Telerobotic and telepresence capabilities are considered by the agency to be "grand challenges" for space technology. While human visits to the lunar surface provide optimal opportunities for field geologic exploration, on-orbit telerobotics may provide attractive early opportunities for geologic exploration, resource prospecting, and other precursor activities in advance of human exploration campaigns and ISRU processing. The Exploration Platform provides a perfect port for a small lander which could be refueled and used for multiple missions including sample return. The EVA and robotic capabilities of the EML Exploration Platform allow the lander to be serviced both internally and externally, based on operational requirements. The placement of the platform at an EML point allows the lander to access any site on the lunar surface, thus providing the global lunar surface access that is commonly understood to be required in order to enable a robust lunar exploration program. Designing the sample return lander for low-energy trajectories would reduce the overall mass and potentially increase the sample return mass. The Initial Lunar Mission -Building upon Apollo sample investigations, the recent results of the LRO/LCROSS, international missions such as Chandrayaan-1, and legacy missions including Lunar Prospector, and Clementine, among the most important science and exploration goals is surface prospecting for lunar resources and to provide ground truth for orbital observations. Being able to constrain resource production potential will allow us to estimate the prospect for reducing the size of payloads launched from Earth required for Solar System exploration. Flight opportunities for something like the NASA RESOLVE instrument suite to areas of high science and exploration interest could be used to refine and improve future Exploration architectures, reducing the outlays required for cis-lunar operations. Summary - EML points are excellent for placement of a semi-permanent human-tended Exploration Platform both in the near term, while providing important infrastructure and deep-space experience that will be built upon to gradually increase long-term operational capabilities.

Neighborhoods in Development: Human Development Index and Self-Organizing Maps

ERIC Educational Resources Information Center

Rende, Sevinc; Donduran, Murat

2013-01-01

The Human Development Index (HDI) has been instrumental in broadening the discussion of economic development beyond money-metric progress, in particular, by ranking a country against other countries in terms of the well being of their citizens. We propose self-organizing maps to explore similarities among countries using the components of the HDI…

Exploring Visuomotor Priming Following Biological and Non-Biological Stimuli

ERIC Educational Resources Information Center

Gowen, E.; Bradshaw, C.; Galpin, A.; Lawrence, A.; Poliakoff, E.

2010-01-01

Observation of human actions influences the observer's own motor system, termed visuomotor priming, and is believed to be caused by automatic activation of mirror neurons. Evidence suggests that priming effects are larger for biological (human) as opposed to non-biological (object) stimuli and enhanced when viewing stimuli in mirror compared to…

Searching for Lunar Water: The Lunar Volatile Resources Analysis Package

NASA Technical Reports Server (NTRS)

Morse, A. D.; Barber, S. J.; Dewar, K. R.; Pillinger, J. M.; Sheridan, S.; Wright, I, P.; Gibson, E. K.; Merrifield, J. A.; Howe, C. J.; Waugh, L. J.;

2015 Summer Series - Jason Crusan - Pioneering Space - Not Your Great-Great-Grandparent's Manifest Destiny

NASA Image and Video Library

2015-07-14

Exploration is an innate characteristic of the human species. By launching into the unknown, NASA drives our expeditions beyond Earth and embarks in the long-term efforts of 'pioneering space' for this and future generations. NASA will develop the ability for humans to go farther and stay longer in space with an ever-decreasing need to be reliant on Earth. Jason Crusan, Director of Advanced Exploration Systems Division at NASA Headquarters, describes what the future of pioneering space will look like in the galactic Wild West.

Vulnerability as a key to authenticity.

PubMed

Daniel, L E

1998-01-01

Vulnerability is explored as a human trait that gives nurses an opportunity to engage in authentic nursing. Vulnerability in both nurse and patient is necessary for the practice of nursing with caring as its basic premise. Philosophic discourse. Vulnerability is explored in terms of its traditional connotation and existential meaning. To be authentic, nurses must be aware of their own vulnerability, recognize themselves in others, and be willing to enter into mutual vulnerability. If nurses deny the opportunity to be vulnerable, they deny the opportunity to participate in humanness and are more likely to dehumanize others.

Hippocampus, perirhinal cortex, and complex visual discriminations in rats and humans

PubMed Central

Hales, Jena B.; Broadbent, Nicola J.; Velu, Priya D.

2015-01-01

Structures in the medial temporal lobe, including the hippocampus and perirhinal cortex, are known to be essential for the formation of long-term memory. Recent animal and human studies have investigated whether perirhinal cortex might also be important for visual perception. In our study, using a simultaneous oddity discrimination task, rats with perirhinal lesions were impaired and did not exhibit the normal preference for exploring the odd object. Notably, rats with hippocampal lesions exhibited the same impairment. Thus, the deficit is unlikely to illuminate functions attributed specifically to perirhinal cortex. Both lesion groups were able to acquire visual discriminations involving the same objects used in the oddity task. Patients with hippocampal damage or larger medial temporal lobe lesions were intact in a similar oddity task that allowed participants to explore objects quickly using eye movements. We suggest that humans were able to rely on an intact working memory capacity to perform this task, whereas rats (who moved slowly among the objects) needed to rely on long-term memory. PMID:25593294

How Should We Value a Planet?

NASA Astrophysics Data System (ADS)

Haqq-Misra, J.

2014-04-01

The idea that a planet or its biota may be intrinsically valuable, apart from its usefulness to humans, is contentious among ethicists, while difficulties abound in attempting to decide what is objectively better or worse for a planet or life. As a way of dissecting the issue of value and life, I present a two-axis comparative tool for ethical frameworks that considers the intrinsic or instrumental value placed upon organisms, environments, planetary systems, and space. I discuss ethical considerations relevant to contemporary space exploration, near-future human exploration of Solar System bodies, and long-term possibilities of interplanetary colonization. This allows for more transparent discussions of value with regard to future space exploration or the discovery of extraterrestrial life.

HEDS-UP Mars Exploration Forum

NASA Technical Reports Server (NTRS)

Budden, Nancy Ann (Editor); Duke, Micheal B. (Editor)

1998-01-01

In the early 1990s, Duke and Budden convened a series of workshops addressing mission rationale, exploration objectives, and key constraints and issues facing human crews on Mars. The focal point was "why" the U.S. should fly humans to Mars. In the mid-1990s, strategies for a Mars mission matured and evolved, driven formally by NASA Johnson Space Center's Office of Exploration. In 1997, NASA published a report capturing the current thinking: the NASA Mars Reference Mission. In the 1997-1998 school year, HEDS-UP sponsored six universities to conduct design studies on Mars exploration, using the Reference Mission as a basis for their work. The 1998 Mars Exploration Forum presents the results of these university studies, suggesting "how" we might explore Mars, in terms of specific technical components that would enable human missions to Mars. A primary objective of the HEDS-UP Mars Exploration Forum was to provide a forum for active interaction among NASA, industry, and the university community on the subject of human missions to Mars. NASA scientists and engineers were asked to present the state of exploration for Mars mission options currently under study. This status "snapshot" of current Mars strategies set the stage for the six HEDS-UP universities to present their final design study results. Finally, a panel of industry experts discussed readiness for human missions to Mars as it pertains to the aerospace industries and technologies. A robust poster session provided the backdrop for government-industry-university discussions and allowed for feedback to NASA on the Mars Reference Mission. The common thread woven through the two days was discussion of technologies, proven and emerging, that will be required to launch, land, and sustain human crews on the Red Planet. As this decade (and indeed this millenium) draws to a close, Mars will continue to loom in our sights as the next target for human space exploration. It is our hope that the efforts of the Mars Exploration Forum will serve as one small contribution toward the ultimate goal of humans exploring Mars.

A Potential Role for smallsats and Cubesats in Lunar Exploration

NASA Astrophysics Data System (ADS)

Carpenter, James; Fisackerly, Richard; Houdou, Bérengère; De Rosa, Diego; Schiemann, Jens D.; Walker, Roger; Zeppenfeldt, Frank

2015-04-01

The Moon is an important exploration destination for ESA, which is currently engaged in activities to access and exploit the Moon through developments in future human exploration systems and precursor robotic surface missions. However, recent major advancements in Smallsat and Cubesat technologies, and their application to fields such as Earth imaging and atmospheric science, has opened the possibility of utilising these smaller, lower cost platforms beyond LEO and potentially at the Moon. ESA is interested in understanding how emerging Smallsat & Cubesat instrument and platform technology could be applied to Lunar Exploration, particularly in the fields of technology demonstration and investigations which can be precursors to longer term l exploration activies. Lunar Cubesats can offer an means of access to the Moon, which complements larger ESA-led opportunities on international surface missions and via future human exploration systems. In this talk ESA will outline its current objectives in Lunar Exploration and highlight potential future opportunities for Smallsat and Cubesat platforms to play a role.

Human ocular anatomy.

PubMed

Kels, Barry D; Grzybowski, Andrzej; Grant-Kels, Jane M

2015-01-01

We review the normal anatomy of the human globe, eyelids, and lacrimal system. This contribution explores both the form and function of numerous anatomic features of the human ocular system, which are vital to a comprehensive understanding of the pathophysiology of many oculocutaneous diseases. The review concludes with a reference glossary of selective ophthalmologic terms that are relevant to a thorough understanding of many oculocutaneous disease processes. Copyright © 2015 Elsevier Inc. All rights reserved.

Experiences of Followers in the Development of the Leader-Follower Relationship in Long-Term Health Care: A Phenomenological Study

ERIC Educational Resources Information Center

Lucia, David

2010-01-01

This descriptive phenomenological study explored the perceptions and experiences of followers in the development of the leader-follower relationship, within a long-term health care environment. This study is also framed within the disciplinary context of human resource development (HRD). This study addressed the research question, "During your…

A new era in palaeomicrobiology: prospects for ancient dental calculus as a long-term record of the human oral microbiome.

PubMed

Warinner, Christina; Speller, Camilla; Collins, Matthew J

2015-01-19

The field of palaeomicrobiology is dramatically expanding thanks to recent advances in high-throughput biomolecular sequencing, which allows unprecedented access to the evolutionary history and ecology of human-associated and environmental microbes. Recently, human dental calculus has been shown to be an abundant, nearly ubiquitous, and long-term reservoir of the ancient oral microbiome, preserving not only microbial and host biomolecules but also dietary and environmental debris. Modern investigations of native human microbiota have demonstrated that the human microbiome plays a central role in health and chronic disease, raising questions about changes in microbial ecology, diversity and function through time. This paper explores the current state of ancient oral microbiome research and discusses successful applications, methodological challenges and future possibilities in elucidating the intimate evolutionary relationship between humans and their microbes.

Human factors research as part of a Mars exploration analogue mission on Devon Island

NASA Astrophysics Data System (ADS)

Binsted, Kim; Kobrick, Ryan L.; Griofa, Marc Ó.; Bishop, Sheryl; Lapierre, Judith

2010-06-01

Human factors research is a critical element of space exploration as it provides insight into a crew's performance, psychology and interpersonal relationships. Understanding the way humans work in space-exploration analogue environments permits the development and testing of countermeasures for and responses to potential hazardous situations, and can thus help improve mission efficiency and safety. Analogue missions, such as the one described here, have plausible mission constraints and operational scenarios, similar to those that a real Mars crew would experience. Long duration analogue studies, such as those being conducted at the Flashline Mars Arctic Research Station (FMARS) on Devon Island, Canada, offer an opportunity to study mission operations and human factors in a semi-realistic environment, and contribute to the design of missions to explore the Moon and Mars. The FMARS XI Long Duration Mission (F-XI LDM) was, at four months, the longest designed analogue Mars mission conducted to date, and thus provides a unique insight into human factors issues for long-duration space exploration. Here, we describe the six human factors studies that took place during F-XI LDM, and give a summary of their results, where available. We also present a meta-study, which examined the impact of the human-factors research itself on crew schedule and workload. Based on this experience, we offer some lessons learnt: some aspects (perceived risk and crew motivation, for example) of analogue missions must be realistic for study results to be valid; human factors studies are time-consuming, and should be fully integrated into crew schedules; and crew-ground communication and collaboration under long-term exploration conditions can present serious challenges.

Continuing the International Roadmapping Effort - An Introduction to the Evolution of the ISECG Global Exploration Roadmap

NASA Astrophysics Data System (ADS)

Schlutz, Juergen; Hufenbach, Bernhard; Laurini, Kathy; Spiero, Francois

2016-07-01

Future space exploration goals call for sending humans and robots beyond low Earth orbit and establishing sustained access to destinations such as the Moon, asteroids and Mars. Space agencies participating in the International Space Exploration Coordination Group (ISECG) are discussing an international approach for achieving these goals, documented in ISECG's Global Exploration Roadmap (GER). The GER reference scenario reflects a step-wise evolution of critical capabilities from ISS to missions in the lunar vicinity in preparation for the journey of humans to Mars. As ISECG agencies advance their individual planning, they also advance the mission themes and reference architecture of the GER to consolidate common goals, near-term mission scenarios and initial opportunities for collaboration. In this context, particular focus has been given to the Better understanding and further refinement of cislunar infrastructure and potential lunar transportation architecture Interaction with international science communities to identify and articulate the scientific opportunities of the near-term exploration mission themes Coordination and consolidation of interest in lunar polar volatiles prospecting and potential for in-situ resource utilisation Identification and articulation of the benefits from exploration and the technology transfer activities The paper discusses the ongoing roadmapping activity of the ISECG agencies. It provides an insight into the status of the above activities and an outlook towards the evolution of the GER that is currently foreseen in the 2017 timeframe.

A Three-Tier Citizenship: Can the State in Tanzania Guarantee Linguistic Human Rights?

ERIC Educational Resources Information Center

Rubagumya, Casmir M.; Afitska, Oksana; Clegg, John; Kiliku, Patrick

2011-01-01

This paper explores how the concept of linguistic citizenship can be applied to the Tanzanian situation in terms of the delivery of bilingual education as well as addressing issues of equity and quality in education. It starts by a brief overview of how the concepts "linguistic human rights" and "linguistic citizenship" are…

Mars Summit Explores Options for Human Missions to the Red Planet

NASA Astrophysics Data System (ADS)

Showstack, Randy

2013-05-01

The United States "needs to begin the homesteading and settlement of Mars," Edwin "Buzz" Aldrin told participants at the Humans to Mars Summit on 8 May in Washington, D. C. "It is within reach technically and budgetarily. Even in a period of fiscal challenges, the United States needs to consider this program with long-term planning."

Viewing Objects and Planning Actions: On the Potentiation of Grasping Behaviours by Visual Objects

ERIC Educational Resources Information Center

Makris, Stergios; Hadar, Aviad A.; Yarrow, Kielan

2011-01-01

How do humans interact with tools? Gibson (1979) suggested that humans perceive directly what tools afford in terms of meaningful actions. This "affordances" hypothesis implies that visual objects can potentiate motor responses even in the absence of an intention to act. Here we explore the temporal evolution of motor plans afforded by common…

LSG_Broll

NASA Image and Video Library

2018-05-15

NASA engineers discussed the Life Sciences Glovebox, the agency's newest research facility for the International Space Station today at Marshall Space Flight Center in Huntsville, Alabama. The Life Sciences Glovebox will be used to study the long-term impact of microgravity on human physiology, revealing new ways to improve life on Earth while protecting human explorers during long-duration deep space missions.

Post-compulsory Education and Training: A Modernist Project.

ERIC Educational Resources Information Center

Chappell, Clive

1996-01-01

Explores how modernist paradigms (empiricism, rationalism, positivism, humanism, and critical theory) have shaped postcompulsory education. Suggests the potential influence of postmodernism in terms of critiquing modernist views and developing future education and training systems. (SK)

In defense of the dignity of being human.

PubMed

Gaylin, W

1984-08-01

The concept of human dignity is examined in terms of the religious belief that man is created in God's image and from the Kantian viewpoint that man's autonomy gives special value to our species. The theory of psychic determinism and the prospect of genetic engineering of humans are seen as attacks on self determination. Five additional attributes that make humans "special" are explored: conceptual thought, the capacity for technology, our range of emotions, "Lamarckian" environmental genetics, and the freedom to change and modify ourselves.

Long-Duration Human Habitation Beyond Low-Earth Orbit: Why is the Near Future Critical?

NASA Technical Reports Server (NTRS)

Thronson, Harley A.; Lester, Daniel; Hatfield, C. A.

2011-01-01

For more than a decade, habitation systems capable of comfortable human occupation and effective operations beyond low-Earth orbit (LEO) for more than a few weeks have been a priority recommendation to NASA. This capability is a lynch pin for human exploration beyond the Earth-Moon system. Here we describe briefly some relevant concepts and discuss justifications in the current political and financial environment for why near-term human habitation systems beyond LEO is an imperative.

Folk-Psychological Interpretation of Human vs. Humanoid Robot Behavior: Exploring the Intentional Stance toward Robots.

PubMed

Thellman, Sam; Silvervarg, Annika; Ziemke, Tom

2017-01-01

People rely on shared folk-psychological theories when judging behavior. These theories guide people's social interactions and therefore need to be taken into consideration in the design of robots and other autonomous systems expected to interact socially with people. It is, however, not yet clear to what degree the mechanisms that underlie people's judgments of robot behavior overlap or differ from the case of human or animal behavior. To explore this issue, participants ( N = 90) were exposed to images and verbal descriptions of eight different behaviors exhibited either by a person or a humanoid robot. Participants were asked to rate the intentionality, controllability and desirability of the behaviors, and to judge the plausibility of seven different types of explanations derived from a recently proposed psychological model of lay causal explanation of human behavior. Results indicate: substantially similar judgments of human and robot behavior, both in terms of (1a) ascriptions of intentionality/controllability/desirability and in terms of (1b) plausibility judgments of behavior explanations; (2a) high level of agreement in judgments of robot behavior - (2b) slightly lower but still largely similar to agreement over human behaviors; (3) systematic differences in judgments concerning the plausibility of goals and dispositions as explanations of human vs. humanoid behavior. Taken together, these results suggest that people's intentional stance toward the robot was in this case very similar to their stance toward the human.

Human Space Exploration and Radiation Exposure from EVA: 1981-2011

NASA Astrophysics Data System (ADS)

Way, A. R.; Saganti, S. P.; Erickson, G. M.; Saganti, P. B.

2011-12-01

There are several risks for any human space exploration endeavor. One such inevitable risk is exposure to the space radiation environment of which extra vehicular activity (EVA) demands more challenges due to limited amount of protection from space suit shielding. We recently compiled all EVA data comprising low-earth orbit (LEO) from Space Shuttle (STS) flights, International Space Station (ISS) expeditions, and Shuttle-Mir missions. Assessment of such radiation risk is very important, particularly for the anticipated long-term, deep-space human explorations in the near future. We present our assessment of anticipated radiation exposure and space radiation dose contribution to each crew member from a listing of 350 different EVA events resulting in more than 1000+ hrs of total EVA time. As of July 12, 2011, 197 astronauts have made spacewalks (out of 520 people who have gone into Earth orbit). Only 11 women have been on spacewalks.

In-Situ Resource Utilization: Laying the Foundation for "Living off the Land"

NASA Technical Reports Server (NTRS)

Kaplan, D. I.

2000-01-01

The technology to manufacture rocket propellants, breathing and life-support gases, fuel cell reagents, and other consumables on Mars using indigenous Martian resources as feedstock in the production process is known as In-Situ Resource Utilization (ISRU). Several studies of the long-term, committed exploration of Mars by humans show that ISRU is essential ... an enabling technology. The recognized value of ISRU to human exploration is reflected in the NASA Strategic Plan. In the description of the "Strategies and Outcomes" of the Human Exploration and Development of Space (HEDS) Enterprise, the NASA Strategic Plan states: The [HEDS] Enterprise relies on the robotic missions of the Space Science Enterprise to provide extensive knowledge of the geology, environment, and resources of planetary bodies. The Space Science Enterprise missions will also demonstrate the feasibility of utilizing local resources to "live off the land."

Tissue mimicking materials for dental ultrasound

PubMed Central

Singh, Rahul S.; Culjat, Martin O.; Grundfest, Warren S.; Brown, Elliott R.; White, Shane N.

2008-01-01

While acoustic tissue mimicking materials have been explored for a variety of soft and hard biological tissues, no dental hard tissue mimicking materials have been characterized. Tooth phantoms are necessary to better understand acoustic phenomenology within the tooth environment and to accelerate the advancement of dental ultrasound imaging systems. In this study, soda lime glass and dental composite were explored as surrogates for human enamel and dentin, respectively, in terms of compressional velocity, attenuation, and acoustic impedance. The results suggest that a tooth phantom consisting of glass and composite can effectively mimic the acoustic behavior of a natural human tooth. PMID:18396919

Fast, Power-Rich Space Transportation Key to Human Space Exploration and Survival

NASA Astrophysics Data System (ADS)

Chang-Diaz, F.

2002-01-01

above the rest: Physiological debilitation, radiation sickness and psychological stress. Many counter-measures are presently being considered to ameliorate these difficulties; however, in the long run, two important new developments are required: abundant space power and advanced propulsion. Recent initiatives are beginning to focus on these long-term issues. As a result, important technologies currently in the conceptual realm are now being considered for rapid test and deployment. This presentation discusses the promises and the challenges of the new approaches and the profound impact they will have on our capability to survive and explore our new human frontier.

Power Goals for NASA's Exploration Program

NASA Technical Reports Server (NTRS)

Jeevarajan, Judith A.

2009-01-01

Exciting Future Programs ahead for NASA. Power is needed for all Exploration vehicles and for the missions. For long term missions as in Lunar and Mars programs, safe, high energy/ultra high energy batteries are required. Safety is top priority for human-rated missions. Two-fault tolerance to catastrophic failures is required for human-rated safety To meet power safety goals -inherent cell safety may be required; it can lessen complexity of external protective electronics and prevents dependency on hardware that may also have limitations. Inherent cell safety will eliminate the need to carry out screening of all cells (X-rays, vibration, etc.)

Integrating Human Factors into Crew Exploration Vehicle (CEV) Design

NASA Technical Reports Server (NTRS)

Whitmore, Mihriban; Holden, Kritina; Baggerman, Susan; Campbell, Paul

2007-01-01

The purpose of this design process is to apply Human Engineering (HE) requirements and guidelines to hardware/software and to provide HE design, analysis and evaluation of crew interfaces. The topics include: 1) Background/Purpose; 2) HE Activities; 3) CASE STUDY: Net Habitable Volume (NHV) Study; 4) CASE STUDY: Human Modeling Approach; 5) CASE STUDY: Human Modeling Results; 6) CASE STUDY: Human Modeling Conclusions; 7) CASE STUDY: Human-in-the-Loop Evaluation Approach; 8) CASE STUDY: Unsuited Evaluation Results; 9) CASE STUDY: Suited Evaluation Results; 10) CASE STUDY: Human-in-the-Loop Evaluation Conclusions; 11) Near-Term Plan; and 12) In Conclusion

Advanced Exploration Systems Water Architecture Study Interim Results

NASA Technical Reports Server (NTRS)

Sargusingh, Miriam J.

2013-01-01

The mission of the Advanced Exploration System (AES) Water Recovery Project (WRP) is to develop advanced water recovery systems that enable NASA human exploration missions beyond low Earth orbit (LEO). The primary objective of the AES WRP is to develop water recovery technologies critical to near-term missions beyond LEO. The secondary objective is to continue to advance mid-readiness-level technologies to support future NASA missions. An effort is being undertaken to establish the architecture for the AES Water Recovery System (WRS) that meets both near- and long-term objectives. The resultant architecture will be used to guide future technical planning, establish a baseline development roadmap for technology infusion, and establish baseline assumptions for integrated ground and on-orbit Environmental Control and Life Support Systems definition. This study is being performed in three phases. Phase I established the scope of the study through definition of the mission requirements and constraints, as well as identifying all possible WRS configurations that meet the mission requirements. Phase II focused on the near-term space exploration objectives by establishing an International Space Station-derived reference schematic for long-duration (>180 day) in-space habitation. Phase III will focus on the long-term space exploration objectives, trading the viable WRS configurations identified in Phase I to identify the ideal exploration WRS. The results of Phases I and II are discussed in this paper.

Enhancing Lunar Exploration with a Radioisotope Powered Dual Mode Lunar Rover

NASA Astrophysics Data System (ADS)

Elliott, J. O.; Coste, K.; Schriener, T. M.

2005-12-01

The emerging plans for lunar exploration and establishment of a permanent human presence on the moon will require development of numerous infrastructure elements to facilitate their implementation. One such element, which manifestly demonstrated its worth in the Apollo missions, is the lunar roving vehicle. While the original Apollo lunar rovers were designed for single mission use, the intention of proceeding with a long-term sustained lunar exploration campaign gives new impetus to consideration of a lunar roving vehicle with extended capabilities, including the ability to support multiple sequential human missions as well as teleoperated exploration activities between human visits. This paper presents a preliminary design concept for such a vehicle, powered by radioisotope power systems which would give the rover greatly extended capabilities and the versatility to operate at any latitude over the entire lunar day/night cycle. The rover would be used for human transportation during astronaut sorties, and be reconfigured for teleoperation by earth-based controllers during the times between crewed landings. In teleoperated mode the rover could be equipped with a range of scientific instrument suites for exploration and detailed assessment of the lunar environment on a regional scale. With modular payload attachments, the rover could be modified between missions to carry out a variety of scientific and utilitarian tasks, including regolith reconfiguration in support of establishment of a permanent human base.

HERRO: A Science-Oriented Strategy for Crewed Missions Beyond LEO

NASA Technical Reports Server (NTRS)

Schmidt, George R.

2011-01-01

This paper presents an exploration strategy for human missions beyond Low Earth Orbit (LEO) and the Moon that combines the best features of human and robotic spaceflight. This "Human Exploration using Real-time Robotic Operations" (HERRO) strategy refrains from placing humans on the surfaces of the Moon and Mars in the near-term. Rather, it focuses on sending piloted spacecraft and crews into orbit around exploration targets of interest, such as Mars, and conducting astronaut exploration of the surfaces using telerobots and remotely controlled systems. By eliminating the significant communications delay with Earth due to the speed of light limit, teleoperation provides scientists real-time control of rovers and other sophisticated instruments, in effect giving them a "virtual presence" on planetary surfaces, and thus expanding the scientific return at these destinations. It also eliminates development of the numerous man-rated landers, ascent vehicles and surface systems that are required to land humans on planetary surfaces. The propulsive requirements to travel from LEO to many destinations with shallow gravity-wells in the inner solar system are quite similar. Thus, a single spacecraft design could perform a variety of missions, including orbit-based surface exploration of the Moon, Mars and Venus, and rendezvous with Near Earth Asteroids (NEAs), as well as Phobos and Deimos. Although HERRO bypasses many of the initial steps that have been historically associated with human space exploration, it opens the door to many new destinations that are candidates for future resource utilization and settlement. HERRO is a first step that takes humans to exciting destinations beyond LEO, while expanding the ability to conduct science within the inner solar system.

Beyond Earth's Boundaries: Human Exploration of the Solar System in the 21st Century. 1988 Annual Report to the Administrator.

ERIC Educational Resources Information Center

National Aeronautics and Space Administration, Washington, DC. Office of Exploration.

In June 1987, the National Aeronautics and Space Administration (NASA) Administrator established the Office of Exploration in response to a national need for a long-term goal to energize the civilian space program and stimulate the development of new technology. This document describes work accomplished in developing the knowledge base that will…

NASA Lunar Mining and Construction Activities and Plans

NASA Technical Reports Server (NTRS)

Sanders, Gerald B.; Larson, William E.; Sacksteder, Kurt R.

2009-01-01

The Space Exploration Policy enacted by the US Congress in 2005 calls for the US National Aeronautics and Space Administration (NASA) to implement a sustained and affordable human and robotic program to explore the solar system and beyond; Extend human presence across the solar system, starting with a human return to the Moon by the year 2020, in preparation for human exploration of Mars and other destinations; Develop the innovative technologies, knowledge, and infrastructures both to explore and to support decisions about the destinations for human exploration; and Promote international and commercial participation in exploration to further U.S. scientific, security, and economic interests. In 2006, NASA released the Lunar Architecture Study, which proposed establishing a lunar Outpost on the Moon with international participation to extend human presence beyond Earth's orbit, pursue scientific activities, use the Moon to prepare for future human missions to Mars, and expand Earth s economic sphere. The establishment of sustained human presence on the Moon for science and exploration combines the design, integration, and operation challenges experienced from both the short Apollo lunar missions and the build-up and sustained crew operations of the International Space Station (ISS). Apollo experience reminds developers and mission planners that hardware must operate under extremely harsh environmental and abrasive conditions and every kilogram of mass and payload must be critical to achieve the mission s objectives due to the difficulty and cost of reaching the lunar surface. Experience from the ISS reminds developers and mission planners that integration of all hardware must be designed and planned from the start of the program, operations and evolution of capabilities on a continuous basis are important, and long-term life-cycle costs and logistical needs are equally or more important than minimizing early development and test costs. Overarching all of this is the need to implement efforts that are sustainable and affordable. One area NASA is developing that can significantly change how systems required for sustained human presence are designed and integrated, as well as potentially break our reliance on Earth supplied logistics, is In-Situ Resource Utilization (ISRU). ISRU, also known living off the land, involves the extraction and processing of local resources into useful products. In particular, the ability to make propellants, life support consumables, fuel cell reagents, and radiation shielding can significantly reduce the cost, mass, and risk of sustained human activities beyond Earth. Also, the ability to modify the lunar landscape for safer landing, transfer of payloads from the lander an outpost, dust generation mitigation, and infrastructure placement and buildup are also extremely important for long-term lunar operations. While extra-terrestrial excavation, material handling and processing, and site preparation and construction may be new to NASA and other space agencies, there is extensive terrestrial hardware and commercial experience that can be leveraged. This paper will provide an overview of current NASA activities in lunar ISRU mining and construction and how terrestrial experience in these areas are important to achieving the goal of affordable and sustainable human exploration.

A new era in palaeomicrobiology: prospects for ancient dental calculus as a long-term record of the human oral microbiome

PubMed Central

Warinner, Christina; Speller, Camilla; Collins, Matthew J.

2015-01-01

The field of palaeomicrobiology is dramatically expanding thanks to recent advances in high-throughput biomolecular sequencing, which allows unprecedented access to the evolutionary history and ecology of human-associated and environmental microbes. Recently, human dental calculus has been shown to be an abundant, nearly ubiquitous, and long-term reservoir of the ancient oral microbiome, preserving not only microbial and host biomolecules but also dietary and environmental debris. Modern investigations of native human microbiota have demonstrated that the human microbiome plays a central role in health and chronic disease, raising questions about changes in microbial ecology, diversity and function through time. This paper explores the current state of ancient oral microbiome research and discusses successful applications, methodological challenges and future possibilities in elucidating the intimate evolutionary relationship between humans and their microbes. PMID:25487328

What Is the Moral Imperative of Workplace Learning: Unlocking the DaVinci Code of Human Resource Development?

ERIC Educational Resources Information Center

Short, Tom

2006-01-01

In the course of the author's doctoral study, he is exploring the strategic linkages between learning activities in the modern workplace and the long-term success they bring to organisations. For many years, this challenge has been the Holy Grail of human resource (HR) development practitioners, who invest heavily on training and professional…

National Space Biomedical Research Institute

NASA Technical Reports Server (NTRS)

1998-01-01

The National Space Biomedical Research Institute (NSBRI) sponsors and performs fundamental and applied space biomedical research with the mission of leading a world-class, national effort in integrated, critical path space biomedical research that supports NASA's Human Exploration and Development of Space (HEDS) Strategic Plan. It focuses on the enabling of long-term human presence in, development of, and exploration of space. This will be accomplished by: designing, implementing, and validating effective countermeasures to address the biological and environmental impediments to long-term human space flight; defining the molecular, cellular, organ-level, integrated responses and mechanistic relationships that ultimately determine these impediments, where such activity fosters the development of novel countermeasures; establishing biomedical support technologies to maximize human performance in space, reduce biomedical hazards to an acceptable level, and deliver quality medical care; transferring and disseminating the biomedical advances in knowledge and technology acquired through living and working in space to the benefit of mankind in space and on Earth, including the treatment of patients suffering from gravity- and radiation-related conditions on Earth; and ensuring open involvement of the scientific community, industry, and the public at large in the Institute's activities and fostering a robust collaboration with NASA, particularly through Johnson Space Center.

Lunar base - A stepping stone to Mars

NASA Technical Reports Server (NTRS)

Duke, M. B.; Mendell, W. W.; Roberts, B. B.

1985-01-01

Basic elements of technology and programmatic development are identified that appear relevant to the Case for Mars, starting from a base on the moon. The moon is a logical stepping stone toward human exploration of Mars because a lunar base can provide the first test of human ability to use the resources of another planetary body to provide basic materials for life support. A lunar base can provide the first long-term test of human capability to work and live in a reduced (but not zero) gravity field. A lunar base requires creation of the elements of a space transportation system that will be necessary to deliver large payloads to Mars and the space operations capability and experience necessary to carry out a Mars habitation program efficiently and with high reliability. A lunar base is feasible for the first decade of the 21st Century. Scenarios have been studied that provide advanced capability by 2015 within budget levels that are less than historical U.S. space expenditures (Apollo). Early return on the investment in terms of knowledge, practical experience and lunar products are important in gaining momentum for an expanded human exploration of the solar system and the eventual colonization of Mars.

Common In-Situ Consumable Production Plant for Robotic Mars Exploration

NASA Technical Reports Server (NTRS)

Sanders, G. B.; Trevathan, J. R.; Peters, T. A.; Baird, R. S.

2000-01-01

Utilization of extraterrestrial resources, or In-Situ Resource Utilization (ISRU), is viewed by the Human Exploration and Development of Space (HEDS) Enterprise as an enabling technology for the exploration and commercial development of space. A key subset of ISRU which has significant cost, mass, and risk reduction benefits for robotic and human exploration, and which requires a minimum of infrastructure, is In-Situ Consumable Production (ISCP). ISCP involves acquiring, manufacturing, and storing mission consumables from in situ resources, such as propellants, fuel cell reagents, and gases for crew and life support, inflation, science and pneumatic equipment. One of the four long-term goals for the Space Science Enterprise (SSE) is to 'pursue space science programs that enable and are enabled by future human exploration beyond low-Earth orbit - a goal exploiting the synergy with the human exploration of space'. Adequate power and propulsion capabilities are critical for both robotic and human exploration missions. Minimizing the mass and volume of these systems can reduce mission cost or enhance the mission by enabling the incorporation of new science or mission-relevant equipment. Studies have shown that in-situ production of oxygen and methane propellants can enhance sample return missions by enabling larger samples to be returned to Earth or by performing Direct Earth Return (DER) sample return missions instead of requiring a Mars Orbit Rendezvous (MOR). Recent NASA and Department of Energy (DOE) work on oxygen and hydrocarbon-based fuel cell power systems shows the potential of using fuel cell power systems instead of solar arrays and batteries for future rovers and science equipment. The development and use of a common oxygen/methane ISCP plant for propulsion and power generation can extend and enhance the scientific exploration of Mars while supporting the development and demonstration of critical technologies and systems for the human exploration of Mars.

Common In-Situ Consumable Production Plant for Robotic Mars Exploration

NASA Astrophysics Data System (ADS)

Sanders, G. B.; Trevathan, J. R.; Peters, T. A.; Baird, R. S.

2000-07-01

Utilization of extraterrestrial resources, or In-Situ Resource Utilization (ISRU), is viewed by the Human Exploration and Development of Space (HEDS) Enterprise as an enabling technology for the exploration and commercial development of space. A key subset of ISRU which has significant cost, mass, and risk reduction benefits for robotic and human exploration, and which requires a minimum of infrastructure, is In-Situ Consumable Production (ISCP). ISCP involves acquiring, manufacturing, and storing mission consumables from in situ resources, such as propellants, fuel cell reagents, and gases for crew and life support, inflation, science and pneumatic equipment. One of the four long-term goals for the Space Science Enterprise (SSE) is to 'pursue space science programs that enable and are enabled by future human exploration beyond low-Earth orbit - a goal exploiting the synergy with the human exploration of space'. Adequate power and propulsion capabilities are critical for both robotic and human exploration missions. Minimizing the mass and volume of these systems can reduce mission cost or enhance the mission by enabling the incorporation of new science or mission-relevant equipment. Studies have shown that in-situ production of oxygen and methane propellants can enhance sample return missions by enabling larger samples to be returned to Earth or by performing Direct Earth Return (DER) sample return missions instead of requiring a Mars Orbit Rendezvous (MOR). Recent NASA and Department of Energy (DOE) work on oxygen and hydrocarbon-based fuel cell power systems shows the potential of using fuel cell power systems instead of solar arrays and batteries for future rovers and science equipment. The development and use of a common oxygen/methane ISCP plant for propulsion and power generation can extend and enhance the scientific exploration of Mars while supporting the development and demonstration of critical technologies and systems for the human exploration of Mars.

Report on the COSPAR Workshop on Refining Planetary Protection Requirements for Human Missions

NASA Astrophysics Data System (ADS)

Spry, James Andrew; Rummel, John; Conley, Catharine; Race, Margaret; Kminek, Gerhard; Siegel, Bette

2016-07-01

A human mission to Mars has been the driving long-term goal for the development of the Global Exploration Roadmap by the International Space Exploration Coordination Group. Additionally, multiple national space agencies and commercial organizations have published similar plans and aspirations for human missions beyond LEO. The current COSPAR planetary protection "Guidelines for Human Missions to Mars" were developed in a series of workshops in the early 2000s and adopted into COSPAR policy at the Montreal Assembly in 2008. With changes and maturation in mission architecture concepts and hardware capabilities, the holding of a workshop provided an opportunity for timely review of these guidelines and their interpretation within current frameworks provided by ISECG and others. The COSPAR Workshop on Refining Planetary Protection Requirements for Human Missions was held in the US in spring 2016 to evaluate recent efforts and activities in the context of current COSPAR policy, as well as collect inputs from the various organizations considering crewed exploration missions to Mars and precursor robotic missions focused on surface material properties and environmental challenges. The workshop also considered potential updates to the COSPAR policy for human missions across a range of planetary destinations. This paper will report on those deliberations.

The Hebrus Valles Exploration Zone: Access to the Martian Surface and Subsurface

NASA Astrophysics Data System (ADS)

Davila, A.; Fairén, A. G.; Rodríguez, A. P.; Schulze-Makuch, D.; Rask, J.; Zavaleta, J.

2015-10-01

The Hebrus Valles EZ represents a diverse setting with multiple geological contacts and layers, possible remnant water ice and protected subsurface environments, which could be critical for the establishment of long-term human settlements.

The Importance of Conducting Life Sciences Experiments on the Deep Space Gateway Platform

NASA Astrophysics Data System (ADS)

Bhattacharya, S.

2018-02-01

Life science research on the Deep Space Gateway platform is an important precursor for long term human exploration of deep space. Ideas for utilizing flight hardware and well characterized model organisms will be discussed.

National Aeronautics and Space Administration (NASA) Environmental Control and Life Support (ECLS) Capability Roadmap Development for Exploration

NASA Technical Reports Server (NTRS)

Bagdigian, Robert M.; Carrasquillo, Robyn L.; Metcalf, Jordan; Peterson, Laurie

2012-01-01

NASA is considering a number of future human space exploration mission concepts. Although detailed requirements and vehicle architectures remain mostly undefined, near-term technology investment decisions need to be guided by the anticipated capabilities needed to enable or enhance the mission concepts. This paper describes a roadmap that NASA has formulated to guide the development of Environmental Control and Life Support Systems (ECLSS) capabilities required to enhance the long-term operation of the International Space Station (ISS) and enable beyond-Low Earth Orbit (LEO) human exploration missions. Three generic mission types were defined to serve as a basis for developing a prioritized list of needed capabilities and technologies. Those are 1) a short duration micro gravity mission; 2) a long duration transit microgravity mission; and 3) a long duration surface exploration mission. To organize the effort, ECLSS was categorized into three major functional groups (atmosphere, water, and solid waste management) with each broken down into sub-functions. The ability of existing, flight-proven state-of-the-art (SOA) technologies to meet the functional needs of each of the three mission types was then assessed. When SOA capabilities fell short of meeting the needs, those "gaps" were prioritized in terms of whether or not the corresponding capabilities enable or enhance each of the mission types. The resulting list of enabling and enhancing capability gaps can be used to guide future ECLSS development. A strategy to fulfill those needs over time was then developed in the form of a roadmap. Through execution of this roadmap, the hardware and technologies needed to enable and enhance exploration may be developed in a manner that synergistically benefits the ISS operational capability, supports Multi-Purpose Crew Vehicle (MPCV) development, and sustains long-term technology investments for longer duration missions. This paper summarizes NASA s ECLSS capability roadmap development process, findings, and recommendation

The Open Gateway: Lunar Exploration in 2050

NASA Technical Reports Server (NTRS)

Lawrence, S.; Neal, C.

2017-01-01

The Moon, with its fundamental science questions and abundant, potentially useful re-sources, is the most viable destination for near-term future human and robotic exploration. Given what we have learned since Apollo, the lunar frontier now presents an entirely new paradigm for planetary exploration. The Lunar Exploration Roadmap [1], which was jointly developed by engineers, planetary scientists, commercial entities, and policymakers, is the cohesive strategic plan for using the Moon and its resources to enable the exploration of all other destinations within the Solar system by leveraging incremental, affordable investments in cislunar infrastructure. Here, we summarize the Lunar Exploration Roadmap, and describe the immense benefits that will arise from its successful implementation.

Human Missions to Near-Earth Asteroids: An Update on NASA's Current Status and Proposed Activities for Small Body Exploration

NASA Technical Reports Server (NTRS)

Abell, P. A.; Mazanek, D. D.; Barbee, B. W.; Mink, R. G.; Landis, R. R.; Adamo, D. R.; Johnson, L. N.; Yeomans, D. K.; Reeves, D. M.; Larman, K. T.;

Does docosahexaenoic acid supplementation in term infants enhance neurocognitive functioning in infancy?

PubMed

Heaton, Alexandra E; Meldrum, Suzanne J; Foster, Jonathan K; Prescott, Susan L; Simmer, Karen

2013-11-20

The proposal that dietary docosahexaenoic acid (DHA) enhances neurocognitive functioning in term infants is controversial. Theoretical evidence, laboratory research and human epidemiological studies have convincingly demonstrated that DHA deficiency can negatively impact neurocognitive development. However, the results from randomized controlled trials (RCTs) of DHA supplementation in human term-born infants have been inconsistent. This article will (i) discuss the role of DHA in the human diet, (ii) explore the physiological mechanisms by which DHA plausibly influences neurocognitive capacity, and (iii) seek to characterize the optimal intake of DHA during infancy for neurocognitive functioning, based on existing research that has been undertaken in developed countries (specifically, within Australia). The major observational studies and RCTs that have examined dietary DHA in human infants and animals are presented, and we consider suggestions that DHA requirements vary across individuals according to genetic profile. It is important that the current evidence concerning DHA supplementation is carefully evaluated so that appropriate recommendations can be made and future directions of research can be strategically planned.

Does docosahexaenoic acid supplementation in term infants enhance neurocognitive functioning in infancy?

PubMed Central

Heaton, Alexandra E.; Meldrum, Suzanne J.; Foster, Jonathan K.; Prescott, Susan L.; Simmer, Karen

2013-01-01

The proposal that dietary docosahexaenoic acid (DHA) enhances neurocognitive functioning in term infants is controversial. Theoretical evidence, laboratory research and human epidemiological studies have convincingly demonstrated that DHA deficiency can negatively impact neurocognitive development. However, the results from randomized controlled trials (RCTs) of DHA supplementation in human term-born infants have been inconsistent. This article will (i) discuss the role of DHA in the human diet, (ii) explore the physiological mechanisms by which DHA plausibly influences neurocognitive capacity, and (iii) seek to characterize the optimal intake of DHA during infancy for neurocognitive functioning, based on existing research that has been undertaken in developed countries (specifically, within Australia). The major observational studies and RCTs that have examined dietary DHA in human infants and animals are presented, and we consider suggestions that DHA requirements vary across individuals according to genetic profile. It is important that the current evidence concerning DHA supplementation is carefully evaluated so that appropriate recommendations can be made and future directions of research can be strategically planned. PMID:24312040

The new science of mind and the future of knowledge.

PubMed

Kandel, Eric

2013-10-30

Understanding mental processes in biological terms makes available insights from the new science of the mind to explore connections between philosophy, psychology, the social sciences, the humanities, and studies of disorders of mind. In this Perspective we examine how these linkages might be forged and how the new science of the mind might serve as an inspiration for further exploration. Copyright © 2013 Elsevier Inc. All rights reserved.

Mothers of Invention: Hubble Engineers Push Robotic 'Evolution' to Save Telescope, Enable New Exploration

NASA Technical Reports Server (NTRS)

Morring, Frank, Jr.

2004-01-01

Robotic technology being developed out of necessity to keep the Hubble Space Telescope operating could also lead to new levels of man-machine team-work in deep-space exploration down the road-if it survives the near-term scramble for funding. Engineers here who have devoted their NASA careers to the concept of humans servicing the telescope in orbit are planning modifications to International Space Station (ISS) robots that would leave the humans on the ground. The work. forced by post-Columbia flight rules that killed a planned shuttle-servicing mission to Hubble, marks another step in the evolution of robot-partners for human space explorers. "Hubble has always been a pathfider for this agency," says Mike Weiss. Hubble deputy program manager technical. "When the space station was flown and assembled, Hubble was the pathfinder. not just for modularity, but for operations, for assembly techniques. Exploration is the next step. Things we're going to do on Hubble are going to be applied to exploration. It's not just putting a robot in space. It's operating a robot in space. It's adapting that robot to what needs to be done the next time you're up there."

In-situ Resource Utilization (ISRU) and Lunar Surface Systems

NASA Technical Reports Server (NTRS)

Sanders, Jerry; Larson, Bill; Sacksteder, Kurt

2007-01-01

This viewgraph presentation reviews the benefits of In-Situ Resource Utilization (ISRU) on the surface of the moon. Included in this review is the commercialization of Lunar ISRU. ISRU will strongly influence architecture and critical technologies. ISRU is a critical capability and key implementation of the Vision for Space Exploration (VSE). ISRU will strongly effects lunar outpost logistics, design and crew safety. ISRU will strongly effect outpost critical technologies. ISRU mass investment is minimal compared to immediate and long-term architecture delivery mass and reuse capabilities provided. Therefore, investment in ISRU constitutes a commitment to the mid and long term future of human exploration.

Behavioral Dynamics in the Cooperative Control of Mixed Human/Robotic Teams

DTIC Science & Technology

2015-01-05

models of cognitive and social psychology play a major role in the work. A particular objective is to develop a fundamental understanding of how...dynamics. In addition to exploring cognitive and social psychological aspects of decision making, research is focused on formal approaches to...SUBJECT TERMS human-machine interactions, two-alternative-forced-choice (TAFC), cognitive and social psychological aspects of decision making, action

Challenges for Electronics in the Vision for Space Exploration

NASA Technical Reports Server (NTRS)

LaBel, Kenneth A.

2005-01-01

This presentation has been a brief snapshot discussing electronics and Exploration-related challenges. The vision for Space Exploration creates a new paradigm for NASA missions. This includes transport (Crew Exploration Vehicle-CEV), and lunar and Mars Exploration and human presence. If one considers the additional hazards faced by these concepts versus more traditional NASA missions, multiple challenges surface for reliable utilization of electronic parts. The true challenge is to provide a risk as low as reasonably achievable (ALARA-a traditional biological radiation exposure term), while still providing cost effective solutions. This presentation also discusses the hazard for electronic parts and exploration, the types of electronic parts for exploration, and the critical juncture for space usage of commercial changes in the electronics world.

Alternative Strategies for Exploring Mars and the Moons of Mars

NASA Technical Reports Server (NTRS)

Drake, Bret G.; Baker, John D.; Hoffman, Stephen J.; Landau, Damon; Voels, Stephen A.

2012-01-01

The possible human exploration of Mars represents one of civilization s next major challenges and is an enterprise that would confirm the potential of humans to leave our home planet system and make our way outward into the cosmos. As exploration endeavors begin to set sights beyond low Earth orbit, potential exploration of the surface of Mars continues to serve as the horizon destination to help focus technology development and research efforts. Recent thoughts on exploration follow a flexible path approach beginning with missions that do not extend down into planetary gravity wells including surface exploration. Consistent with that flexible path strategy is the notion of exploring the moons of Mars, namely Phobos and Deimos, prior to exploring the surface. The premise behind this thought is that exploring Mars moons would be less costly and risky since these missions would avoid the difficulties associated with landing on the surface and subsequent ascent back to orbit. A complete assessment of this strategy has not been performed in the context of the flexible path approach and is needed to clearly understand all of the advantages and disadvantages. This paper examines the strategic implications of possible human exploration of the moons of Mars as a potential prelude to surface exploration. Various operational concepts for Phobos and Deimos exploration that include the infusion of different propulsion technologies are assessed in terms of mission duration, technologies required, overall risk and difficulty, and operational construct. Finally, the strategic implications of each concept are assessed to determine the overall key challenges and strategic links to other key flexible path destinations.

Alternative Strategies for Exploring Mars and the Moons of Mars

NASA Technical Reports Server (NTRS)

Drake, Bret G.; Baker, John D.; Hoffman, Stephen J.; Landau, Damon; Voels, Stephen A.

2012-01-01

The human exploration of Mars represents one of civilizations next major challenges and is an enterprise that would confirm the potential of humans to leave our home planet system and make our way outward into the cosmos. As exploration endeavors begin to set sights beyond low-Earth orbit, exploration of the surface of Mars continues to serve as the horizon destination to help focus technology development and research efforts. Recent thoughts on exploration follow a flexible path approach beginning with missions which do not extend down into planetary gravity wells including surface exploration. Consistent with that flexible path strategy is the notion of exploring the moons of Mars, namely Phobos and Deimos, prior to exploring the surface. The premise behind this thought is that exploring Mars moons would be less costly and risky since these missions would avoid the difficulties associated with landing on the surface and subsequent ascent back to orbit. A complete assessment of this strategy has not been performed in the context of the flexible path approach and is needed to clearly understand all of the advantages and disadvantages. This paper examines the strategic implications of human exploration of the moons of Mars as a potential prelude to surface exploration. Various operational concepts for Phobos and Deimos exploration that include the infusion of different propulsion technologies are assessed in terms of mission duration, technologies required, overall risk and difficulty, and operational construct. Finally, the strategic implications of each concept are assessed to determine the overall key challenges and strategic links to other key flexible path destinations.

ISECG Mission Scenarios and Their Role in Informing Next Steps for Human Exploration Beyond Low Earth Orbit

NASA Technical Reports Server (NTRS)

Culbert, Christopher J.; Mongrard, Olivier; Satoh, Naoki; Goodliff, Kandyce; Seaman, Calvin H.; Troutman, Patrick; Martin, Eric

2011-01-01

The International Space Exploration Coordination Group (ISECG) was established in response to The Global Exploration Strategy (GES): The Framework for Coordination developed by fourteen space agencies* and released in May 2007. This GES Framework Document recognizes that preparing for human space exploration is a stepwise process, starting with basic knowledge and culminating in a sustained human presence in deep space. ISECG has developed several optional global exploration mission scenarios enabling the phased transition from human operations in Low Earth Orbit (LEO) and utilization of the International Space Station (ISS) to human missions beyond LEO leading ultimately to human missions to cis-lunar space, the Moon, Near Earth Asteroids, Mars and its environs. Mission scenarios provide the opportunity for judging various exploration approaches in a manner consistent with agreed international goals and strategies. Each ISECG notional mission scenario reflects a series of coordinated human and robotic exploration missions over a 25-year horizon. Mission scenarios are intended to provide insights into next steps for agency investments, following on the success of the ISS. They also provide a framework for advancing the definition of Design Reference Missions (DRMs) and the concepts for capabilities contained within. Each of the human missions contained in the scenarios has been characterized by a DRM which is a top level definition of mission sequence and the capabilities needed to execute that mission. While DRMs are generally destination focused, they will comprise capabilities which are reused or evolved from capabilities used at other destinations. In this way, an evolutionary approach to developing a robust set of capabilities to sustainably explore our solar system is defined. Agencies also recognize that jointly planning for our next steps, building on the accomplishments of ISS, is important to ensuring the robustness and sustainability of any human exploration plan. Developing a shared long-term vision is important, but agencies recognize this is an evolutionary process and requires consideration of many strategic factors. Strategic factors such as the implications of an emerging commercial space industry in LEO, the opportunity provided by extending ISS lifetime to at least 2020, and the importance of defining a plan which is sustainable in light of inevitable domestic policy shifts are timely for agency consideration.

Folk-Psychological Interpretation of Human vs. Humanoid Robot Behavior: Exploring the Intentional Stance toward Robots

PubMed Central

Thellman, Sam; Silvervarg, Annika; Ziemke, Tom

2017-01-01

People rely on shared folk-psychological theories when judging behavior. These theories guide people’s social interactions and therefore need to be taken into consideration in the design of robots and other autonomous systems expected to interact socially with people. It is, however, not yet clear to what degree the mechanisms that underlie people’s judgments of robot behavior overlap or differ from the case of human or animal behavior. To explore this issue, participants (N = 90) were exposed to images and verbal descriptions of eight different behaviors exhibited either by a person or a humanoid robot. Participants were asked to rate the intentionality, controllability and desirability of the behaviors, and to judge the plausibility of seven different types of explanations derived from a recently proposed psychological model of lay causal explanation of human behavior. Results indicate: substantially similar judgments of human and robot behavior, both in terms of (1a) ascriptions of intentionality/controllability/desirability and in terms of (1b) plausibility judgments of behavior explanations; (2a) high level of agreement in judgments of robot behavior – (2b) slightly lower but still largely similar to agreement over human behaviors; (3) systematic differences in judgments concerning the plausibility of goals and dispositions as explanations of human vs. humanoid behavior. Taken together, these results suggest that people’s intentional stance toward the robot was in this case very similar to their stance toward the human. PMID:29184519

Human Health Countermeasures (HHC) Element Management Plan: Human Research Program. Revision B

NASA Technical Reports Server (NTRS)

Norsk, Peter; Baumann, David

2012-01-01

NASA s Human Research Program (HRP) is an applied research and technology program within the Human Exploration and Operations Mission Directorate (HEOMD) that addresses human health and performance risk mitigation strategies in support of exploration missions. The HRP research and technology development is focused on the highest priority risks to crew health and safety with the goal of ensuring mission success and maintaining long-term crew health. Crew health and performance standards, defined by the NASA Chief Health and Medical Officer (CHMO), set the acceptable risk level for exploration missions. The HRP conducts research to inform these standards as well as provide deliverables, such as countermeasures, that ensure standards can be met to maximize human performance and mission success. The Human Health Countermeasures (HHC) Element was formed as part of the HRP to develop a scientifically-based, integrated approach to understanding and mitigating the health risks associated with human spaceflight. These health risks have been organized into four research portfolios that group similar or related risks. A fifth portfolio exists for managing technology developments and infrastructure projects. The HHC Element portfolios consist of: a) Vision and Cardiovascular; b) Exercise and Performance; c) Multisystem; d) Bone; and e) Technology and Infrastructure. The HHC identifies gaps associated with the health risks and plans human physiology research that will result in knowledge required to more fully understand risks and will result in validated countermeasures to mitigate risks.

Women, Science, and Technology.

ERIC Educational Resources Information Center

Pfafflin, Sheila M.

1984-01-01

Discusses women's low participation in science and technology in terms of equity concerns, human resource utilization, and procedures used to assess scientific merit. Also explores the contributions that psychologists can make by understanding the impact of research and changing technologies on women's lives. (KH)

AES Water Architecture Study Interim Results

NASA Technical Reports Server (NTRS)

Sarguisingh, Miriam J.

2012-01-01

The mission of the Advanced Exploration System (AES) Water Recovery Project (WRP) is to develop advanced water recovery systems in order to enable NASA human exploration missions beyond low earth orbit (LEO). The primary objective of the AES WRP is to develop water recovery technologies critical to near term missions beyond LEO. The secondary objective is to continue to advance mid-readiness level technologies to support future NASA missions. An effort is being undertaken to establish the architecture for the AES Water Recovery System (WRS) that meets both near and long term objectives. The resultant architecture will be used to guide future technical planning, establish a baseline development roadmap for technology infusion, and establish baseline assumptions for integrated ground and on-orbit environmental control and life support systems (ECLSS) definition. This study is being performed in three phases. Phase I of this study established the scope of the study through definition of the mission requirements and constraints, as well as indentifying all possible WRS configurations that meet the mission requirements. Phase II of this study focused on the near term space exploration objectives by establishing an ISS-derived reference schematic for long-duration (>180 day) in-space habitation. Phase III will focus on the long term space exploration objectives, trading the viable WRS configurations identified in Phase I to identify the ideal exploration WRS. The results of Phases I and II are discussed in this paper.

New Directions for NASA's Advanced Life Support Program

NASA Technical Reports Server (NTRS)

Barta, Daniel J.

2006-01-01

Advanced Life Support (ALS), an element of Human Systems Research and Technology s (HSRT) Life Support and Habitation Program (LSH), has been NASA s primary sponsor of life support research and technology development for the agency. Over its history, ALS sponsored tasks across a diverse set of institutions, including field centers, colleges and universities, industry, and governmental laboratories, resulting in numerous publications and scientific articles, patents and new technologies, as well as education and training for primary, secondary and graduate students, including minority serving institutions. Prior to the Vision for Space Exploration (VSE) announced on January 14th, 2004 by the President, ALS had been focused on research and technology development for long duration exploration missions, emphasizing closed-loop regenerative systems, including both biological and physicochemical. Taking a robust and flexible approach, ALS focused on capabilities to enable visits to multiple potential destinations beyond low Earth orbit. ALS developed requirements, reference missions, and assumptions upon which to structure and focus its development program. The VSE gave NASA a plan for steady human and robotic space exploration based on specific, achievable goals. Recently, the Exploration Systems Architecture Study (ESAS) was chartered by NASA s Administrator to determine the best exploration architecture and strategy to implement the Vision. The study identified key technologies required to enable and significantly enhance the reference exploration missions and to prioritize near-term and far-term technology investments. This technology assessment resulted in a revised Exploration Systems Mission Directorate (ESMD) technology investment plan. A set of new technology development projects were initiated as part of the plan s implementation, replacing tasks previously initiated under HSRT and its sister program, Exploration Systems Research and Technology (ESRT). The Exploration Life Support (ELS) Project, under the Exploration Technology Development Program, has recently been initiated to perform directed life support technology development in support of Constellation and the Crew Exploration Vehicle (CEV). ELS) has replaced ALS, with several major differences. Thermal Control Systems have been separated into a new stand alone project (Thermal Systems for Exploration Missions). Tasks in Advanced Food Technology have been relocated to the Human Research Program. Tasks in a new discipline area, Habitation Engineering, have been added. Research and technology development for capabilities required for longer duration stays on the Moon and Mars, including bioregenerative system, have been deferred.

NASA Strategic Roadmap Summary Report

NASA Technical Reports Server (NTRS)

Wilson, Scott; Bauer, Frank; Stetson, Doug; Robey, Judee; Smith, Eric P.; Capps, Rich; Gould, Dana; Tanner, Mike; Guerra, Lisa; Johnston, Gordon

2005-01-01

In response to the Vision, NASA commissioned strategic and capability roadmap teams to develop the pathways for turning the Vision into a reality. The strategic roadmaps were derived from the Vision for Space Exploration and the Aldrich Commission Report dated June 2004. NASA identified 12 strategic areas for roadmapping. The Agency added a thirteenth area on nuclear systems because the topic affects the entire program portfolio. To ensure long-term public visibility and engagement, NASA established a committee for each of the 13 areas. These committees - made up of prominent members of the scientific and aerospace industry communities and senior government personnel - worked under the Federal Advisory Committee Act. A committee was formed for each of the following program areas: 1) Robotic and Human Lunar Exploration; 2) Robotic and Human Exploration of Mars; 3) Solar System Exploration; 4) Search for Earth-Like Planets; 5) Exploration Transportation System; 6) International Space Station; 7) Space Shuttle; 8) Universe Exploration; 9) Earth Science and Applications from Space; 10) Sun-Solar System Connection; 11) Aeronautical Technologies; 12) Education; 13) Nuclear Systems. This document contains roadmap summaries for 10 of these 13 program areas; The International Space Station, Space Shuttle, and Education are excluded. The completed roadmaps for the following committees: Robotic and Human Exploration of Mars; Solar System Exploration; Search for Earth-Like Planets; Universe Exploration; Earth Science and Applications from Space; Sun-Solar System Connection are collected in a separate Strategic Roadmaps volume. This document contains memebership rosters and charters for all 13 committees.

Exploring Relationships between Host Genome and Microbiome: New Insights from Genome-Wide Association Studies

PubMed Central

Abdul-Aziz, Muslihudeen A.; Cooper, Alan; Weyrich, Laura S.

2016-01-01

As our understanding of the human microbiome expands, impacts on health and disease continue to be revealed. Alterations in the microbiome can result in dysbiosis, which has now been linked to subsequent autoimmune and metabolic diseases, highlighting the need to identify factors that shape the microbiome. Research has identified that the composition and functions of the human microbiome can be influenced by diet, age, sex, and environment. More recently, studies have explored how human genetic variation may also influence the microbiome. Here, we review several recent analytical advances in this new research area, including those that use genome-wide association studies to examine host genome–microbiome interactions, while controlling for the influence of other factors. We find that current research is limited by small sample sizes, lack of cohort replication, and insufficient confirmatory mechanistic studies. In addition, we discuss the importance of understanding long-term interactions between the host genome and microbiome, as well as the potential impacts of disrupting this relationship, and explore new research avenues that may provide information about the co-evolutionary history of humans and their microorganisms. PMID:27785127

Cryogenic Propellant Storage and Transfer Technology Demonstration: Advancing Technologies for Future Mission Architectures Beyond Low Earth Orbit

NASA Technical Reports Server (NTRS)

Chojnacki, Kent T.; Crane, Deborah J.; Motil, Susan M.; Ginty, Carol A.; Tofil, Todd A.

2014-01-01

As part of U.S. National Space Policy, NASA is seeking an innovative path for human space exploration, which strengthens the capability to extend human and robotic presence throughout the solar system. NASA is laying the groundwork to enable humans to safely reach multiple potential destinations, including the Moon, asteroids, Lagrange points, and Mars and its environs. In support of this, NASA is embarking on the Technology Demonstration Mission Cryogenic Propellant Storage and Transfer (TDM CPST) Project to test and validate key cryogenic capabilities and technologies required for future exploration elements, opening up the architecture for large cryogenic propulsion stages and propellant depots. The TDM CPST will provide an on-orbit demonstration of the capability to store, transfer, and measure cryogenic propellants for a duration that enables long term human space exploration missions beyond low Earth orbit. This paper will present a summary of the cryogenic fluid management technology maturation effort, infusion of those technologies into flight hardware development, and a summary of the CPST preliminary design.

Aerothermal Instrumentation Loads To Implement Aeroassist Technology in Future Robotic and Human Missions to MARS and Other Locations Within the Solar System

NASA Technical Reports Server (NTRS)

Parmar, Devendra S.; Shams, Qamar A.

2002-01-01

The strategy of NASA to explore space objects in the vicinity of Earth and other planets of the solar system includes robotic and human missions. This strategy requires a road map for technology development that will support the robotic exploration and provide safety for the humans traveling to other celestial bodies. Aeroassist is one of the key elements of technology planning for the success of future robot and human exploration missions to other celestial bodies. Measurement of aerothermodynamic parameters such as temperature, pressure, and acceleration is of prime importance for aeroassist technology implementation and for the safety and affordability of the mission. Instrumentation and methods to measure such parameters have been reviewed in this report in view of past practices, current commercial availability of instrumentation technology, and the prospects of improvement and upgrade according to the requirements. Analysis of the usability of each identified instruments in terms of cost for efficient weight-volume ratio, power requirement, accuracy, sample rates, and other appropriate metrics such as harsh environment survivability has been reported.

Minimum Equipment Lists, Flight Rules and ... Past, Present and Future of Safety Pre-Determined Decisions for Operations

NASA Astrophysics Data System (ADS)

Herd, A.; Wolff, M.

2012-01-01

Extended mission operations, such as human spaceflight to Mars provide an opportunity for take current human exploration beyond Low Earth Orbit, such as the operations undertaken on the International Space Station (ISS). This opportunity also presents a challenge in terms of extending what we currently understand as "remote operations" performed on ISS, offering learning beyond that gained from the successful moon- lander expeditions. As such there is a need to assess how the existing operations concept of ground support teams directing (and supporting) on-orbit ISS operations can be applied in the extended mission concept. The current mission support concept involves three interacting operations products - a short term plan, crew procedures and flight rules. Flight rules (for ISS operations) currently provide overall planning, engineering and operations constraints (including those derived from a safety perspective) in the form of a rule book. This paper will focus specifically on flight rules, and describe the current use of them, and assess the future role of flight rules to support exploration, including the deployment of decision support tools (DSTs) to ensure flight rule compliancy for missions with minimal ground support. Taking consideration of the historical development of pre-planned decisions, and their manifestation within the operations environment, combined with the extended remoteness of human exploration missions, we will propose a future development of this product and a platform on which it could be presented.

Potential Mission Scenarios Post Asteroid Crewed Mission

NASA Technical Reports Server (NTRS)

Lopez, Pedro, Jr.; McDonald, Mark A.

2015-01-01

A deep-space mission has been proposed to identify and redirect an asteroid to a distant retrograde orbit around the moon, and explore it by sending a crew using the Space Launch System and the Orion spacecraft. The Asteroid Redirect Crewed Mission (ARCM), which represents the third segment of the Asteroid Redirect Mission (ARM), could be performed on EM-3 or EM-4 depending on asteroid return date. Recent NASA studies have raised questions on how we could progress from current Human Space Flight (HSF) efforts to longer term human exploration of Mars. This paper will describe the benefits of execution of the ARM as the initial stepping stone towards Mars exploration, and how the capabilities required to send humans to Mars could be built upon those developed for the asteroid mission. A series of potential interim missions aimed at developing such capabilities will be described, and the feasibility of such mission manifest will be discussed. Options for the asteroid crewed mission will also be addressed, including crew size and mission duration.

Sustainable and Autonomic Space Exploration Missions

NASA Technical Reports Server (NTRS)

Hinchey, Michael G.; Sterritt, Roy; Rouff, Christopher; Rash, James L.; Truszkowski, Walter

2006-01-01

Visions for future space exploration have long term science missions in sight, resulting in the need for sustainable missions. Survivability is a critical property of sustainable systems and may be addressed through autonomicity, an emerging paradigm for self-management of future computer-based systems based on inspiration from the human autonomic nervous system. This paper examines some of the ongoing research efforts to realize these survivable systems visions, with specific emphasis on developments in Autonomic Policies.

Building a Better NASA Workforce: Meeting the Workforce Needs for the National Vision for Space Exploration

ERIC Educational Resources Information Center

National Academies Press, 2007

2007-01-01

The Vision for Space Exploration (VSE) announced by President George W. Bush in 2004 sets NASA and the nation on a bold path to return to the Moon and one day put a human on Mars. The long-term endeavor represented by the VSE is, however, subject to the constraints imposed by annual funding. Given that the VSE may take tens of years to implement,…

Emergence of scaling in human-interest dynamics.

PubMed

Zhao, Zhi-Dan; Yang, Zimo; Zhang, Zike; Zhou, Tao; Huang, Zi-Gang; Lai, Ying-Cheng

2013-12-11

Human behaviors are often driven by human interests. Despite intense recent efforts in exploring the dynamics of human behaviors, little is known about human-interest dynamics, partly due to the extreme difficulty in accessing the human mind from observations. However, the availability of large-scale data, such as those from e-commerce and smart-phone communications, makes it possible to probe into and quantify the dynamics of human interest. Using three prototypical "Big Data" sets, we investigate the scaling behaviors associated with human-interest dynamics. In particular, from the data sets we uncover fat-tailed (possibly power-law) distributions associated with the three basic quantities: (1) the length of continuous interest, (2) the return time of visiting certain interest, and (3) interest ranking and transition. We argue that there are three basic ingredients underlying human-interest dynamics: preferential return to previously visited interests, inertial effect, and exploration of new interests. We develop a biased random-walk model, incorporating the three ingredients, to account for the observed fat-tailed distributions. Our study represents the first attempt to understand the dynamical processes underlying human interest, which has significant applications in science and engineering, commerce, as well as defense, in terms of specific tasks such as recommendation and human-behavior prediction.

Emergence of scaling in human-interest dynamics

NASA Astrophysics Data System (ADS)

Zhao, Zhi-Dan; Yang, Zimo; Zhang, Zike; Zhou, Tao; Huang, Zi-Gang; Lai, Ying-Cheng

2013-12-01

Human behaviors are often driven by human interests. Despite intense recent efforts in exploring the dynamics of human behaviors, little is known about human-interest dynamics, partly due to the extreme difficulty in accessing the human mind from observations. However, the availability of large-scale data, such as those from e-commerce and smart-phone communications, makes it possible to probe into and quantify the dynamics of human interest. Using three prototypical ``Big Data'' sets, we investigate the scaling behaviors associated with human-interest dynamics. In particular, from the data sets we uncover fat-tailed (possibly power-law) distributions associated with the three basic quantities: (1) the length of continuous interest, (2) the return time of visiting certain interest, and (3) interest ranking and transition. We argue that there are three basic ingredients underlying human-interest dynamics: preferential return to previously visited interests, inertial effect, and exploration of new interests. We develop a biased random-walk model, incorporating the three ingredients, to account for the observed fat-tailed distributions. Our study represents the first attempt to understand the dynamical processes underlying human interest, which has significant applications in science and engineering, commerce, as well as defense, in terms of specific tasks such as recommendation and human-behavior prediction.

Building long-term constituencies for space exploration: The challenge of raising public awareness and engagement in the United States and in Europe

NASA Astrophysics Data System (ADS)

Ehrenfreund, P.; Peter, N.; Billings, L.

2010-08-01

Space exploration is a multifaceted endeavor and will be a "grand challenge" of the 21st century. It has already become an element of the political agenda of a growing number of countries worldwide. However, the public is largely unaware of space exploration activities and in particular does not perceive any personal benefit. In order to achieve highly ambitious space exploration goals to explore robotically and with humans the inner solar system, space agencies must improve and expand their efforts to inform and raise the awareness of the public about what they are doing, and why. Therefore adopting new techniques aiming at informing and engaging the public using participatory ways, new communication techniques to reach, in particular, the younger generation will be a prerequisite for a sustainable long-term exploration program: as they will enable it and carry most of the associated financial burden. This paper presents an environmental analysis of space exploration in the United States and Europe and investigates the current branding stature of the National Aeronautics and Space Administration (NASA) and the European Space Agency (ESA). We discuss how improved market research and new branding methods can increase public space awareness and improve the image of NASA and ESA. We propose a new participatory approach to engage the public as major stakeholder (along governments, the industrial space sector and the science community) that may provide sufficient resources for and sustainability of a long-term space exploration program.

The Constructive Role of Decisions: Implications from a quantum Approach

DTIC Science & Technology

2016-12-01

objectives. The first was to explore the nature of constructive influences in decision making . The second concerned understanding decision making in...Prisoner’s Dilemma. **First objective; constructive judgments. This is the idea that sometimes making a decision can alter the underlying relevant mental...the performance of the agent. 15.  SUBJECT TERMS EOARD, Quantum Probability, Human Modeling, Human Decision Making 16.  SECURITY CLASSIFICATION OF

Use of Drying Technologies for Resource Recovery from Solid Wastes and Brines

NASA Technical Reports Server (NTRS)

Wignarajah, Kanapathipillai; Alba, Ric; Fisher, John W.; Hogan, John A.; Polonsky, Alex

2010-01-01

Long term storage of unprocessed biological wastes and human wastes can present major health issues and a loss of potential resources. Space vehicles and planetary habitats are typically resource-scarce or resource-limited environments for long-term human habitation. To-date, most of the resources will need to be supplied from Earth, but this may not be possible for long duration human exploration. Based on present knowledge, there is only very limited in-situ resources on planetary habitats. Hence, the opportunity to "live off the land" in a planetary habitat is limited. However, if we assume that wastes generated by human explorers are viewed as resources, there is great potential to utilize and recycle them, thereby reducing the requirements for supply Earth and enabling the "live off the land" exploration scenario. Technologies used for the recovery of resources from wastes should be reliable, safe, easy to operate, fail-proof, modular, automated and preferably multifunctional in being capable of handling mixed solid and liquid wastes. For a lunar habitat, energy does not appear to be the major driving factor amongst the technologies studied. Instead, reliability appears to be more important[1] . This paper reports studies to date on drying technologies to remove water from solid wastes and brines. Experimental performance data obtained for recovery water from wastes and brine are presented. Simplicity of operation of hardware and energy efficiency are discussed. Some improvements and modifications to hardware were performed. Hopefully, this information will assist in future efforts in the "downselection" of technologies for recovery of water and resources from solid wastes and brines.

Lunar Exploration and Science in ESA

NASA Astrophysics Data System (ADS)

Carpenter, J.; Houdou, B.; Fisackerly, R.; De Rosa, D.; Espinasse, S.; Hufenbach, B.

2013-09-01

Lunar exploration continues to be a priority for the European Space Agency (ESA) and is recognized as the next step for human exploration beyond low Earth orbit. The Moon is also recognized as an important scientific target providing vital information on the history of the inner solar system; Earth and the emergence of life, and fundamental information on the formation and evolution of terrestrial planets. The Moon also provides a platform that can be utilized for fundamental science and to prepare the way for exploration deeper into space and towards a human Mars mission, the ultimate exploration goal. Lunar missions can also provide a means of preparing for a Mars sample return mission, which is an important long term robotic milestone. ESA is preparing for future participation in lunar exploration through a combination of human and robotic activities, in cooperation with international partners. These include activities on the ISS and participation with US led Multi-Purpose Crew Vehicle, which is planned for a first unmanned lunar flight in 2017. Future activities planned activities also include participation in international robotic missions. These activities are performed with a view to generating the technologies, capabilities, knowledge and heritage that will make Europe an indispensible partner in the exploration missions of the future. We present ESA's plans for Lunar exploration and the current status of activities. In particular we will show that this programme gives rise to unique scientific opportunities and prepares scientifically and technologically for future exploratory steps.

Complete Subsurface Elemental Composition Measurements With PING

NASA Technical Reports Server (NTRS)

Parsons, A. M.

2012-01-01

The Probing In situ with Neutrons and Gamma rays (PING) instrument will measure the complete bulk elemental composition of the subsurface of Mars as well as any other solid planetary body. PING can thus be a highly effective tool for both detailed local geochemistry science investigations and precision measurements of Mars subsurface reSOurces in preparation for future human exploration. As such, PING is thus fully capable of meeting a majority of both ncar and far term elements in Challenge #1 presented for this conference. Measuring the ncar subsurface composition of Mars will enable many of the MEPAG science goals and will be key to filling an important Strategic Knowledge Gap with regard to In situ Resources Utilization (ISRU) needs for human exploration. [1, 2] PING will thus fill an important niche in the Mars Exploration Program.

Human and Robotic Mission to Small Bodies: Mapping, Planning and Exploration

NASA Technical Reports Server (NTRS)

Neffian, Ara V.; Bellerose, Julie; Beyer, Ross A.; Archinal, Brent; Edwards, Laurence; Lee, Pascal; Colaprete, Anthony; Fong, Terry

2013-01-01

This study investigates the requirements, performs a gap analysis and makes a set of recommendations for mapping products and exploration tools required to support operations and scientific discovery for near- term and future NASA missions to small bodies. The mapping products and their requirements are based on the analysis of current mission scenarios (rendezvous, docking, and sample return) and recommendations made by the NEA Users Team (NUT) in the framework of human exploration. The mapping products that sat- isfy operational, scienti c, and public outreach goals include topography, images, albedo, gravity, mass, density, subsurface radar, mineralogical and thermal maps. The gap analysis points to a need for incremental generation of mapping products from low (flyby) to high-resolution data needed for anchoring and docking, real-time spatial data processing for hazard avoidance and astronaut or robot localization in low gravity, high dynamic environments, and motivates a standard for coordinate reference systems capable of describing irregular body shapes. Another aspect investigated in this study is the set of requirements and the gap analysis for exploration tools that support visualization and simulation of operational conditions including soil interactions, environment dynamics, and communications coverage. Building robust, usable data sets and visualisation/simulation tools is the best way for mission designers and simulators to make correct decisions for future missions. In the near term, it is the most useful way to begin building capabilities for small body exploration without needing to commit to specific mission architectures.

Human System Drivers for Exploration Missions

NASA Technical Reports Server (NTRS)

Kundrot, Craig E.; Steinberg, Susan; Charles, John B.

2010-01-01

Evaluation of DRM4 in terms of the human system includes the ability to meet NASA standards, the inclusion of the human system in the design trade space, preparation for future missions and consideration of a robotic precursor mission. Ensuring both the safety and the performance capability of the human system depends upon satisfying NASA Space Flight Human System Standards.1 These standards in turn drive the development of program-specific requirements for Near-earth Object (NEO) missions. In evaluating DRM4 in terms of these human system standards, the currently existing risk models, technologies and biological countermeasures were used. A summary of this evaluation is provided below in a structure that supports a mission architecture planning activities. 1. Unacceptable Level of Risk The duration of the DRM4 mission leads to an unacceptable level of risk for two aspects of human system health: A. The permissible exposure limit for space flight radiation exposure (a human system standard) would be exceeded by DRM4. B. The risk of visual alterations and abnormally high intracranial pressure would be too high. 1

Human Exploration of the Solar System by 2100

NASA Technical Reports Server (NTRS)

Litchford, Ronald J.

2017-01-01

It has been suggested that the U.S., in concert with private entities and international partners, set itself on a course to accomplish human exploration of the solar system by the end of this century. This is a strikingly bold vision intended to revitalize the aspirations of HSF in service to the security, economic, and scientific interests of the nation. Solar system distance and time scales impose severe requirements on crewed space transportation systems, however, and fully realizing all objectives in support of this goal will require a multi-decade commitment employing radically advanced technologies - most prominently, space habitats capable of sustaining and protecting life in harsh radiation environments under zero gravity conditions and in-space propulsion technologies capable of rapid deep space transits with earth return, the subject of this paper. While near term mission destinations such as the moon and Mars can be accomplished with chemical propulsion and/or high power SEP, fundamental capability constraints render these traditional systems ineffective for solar system wide exploration. Nuclear based propulsion and alternative energetic methods, on the other hand, represent potential avenues, perhaps the only viable avenues, to high specific power space transport evincing reduced trip time, reduced IMLEO, and expanded deep space reach. Here, very long term HSF objectives for solar system wide exploration are examined in relation to the advanced propulsion technology solution landscape including foundational science, technical/engineering challenges, and developmental prospects.

Navigation Concepts for NASA's Constellation Program and Human Missions to the Moon

NASA Technical Reports Server (NTRS)

Moreau, Michael C.

2008-01-01

This viewgraph presentation provides an overview of the Constellation Program, and its goal of returning human presence to the moon. Particular attention is given to the navigation concepts, in terms of the flight to the Moon, the landing on the moon, travel on the surface and the return flight to Earth. Finally the development of new navigation, and communication techniques that will enable the exploration beyond the Moon are reviewed.

Evolving the SP-100 reactor in order to boost large payloads to GEO and to low lunar orbit via nuclear-electric propulsion

NASA Technical Reports Server (NTRS)

English, Robert E.

1991-01-01

In striving to reduce exploration cost and exploration risks, a crucial aspect of the plans is program continuity, i.e., the continuing application of a given technology over a long period so that experience will accumulate from extended testing here on Earth and from a diversity of applications in space. An integrated view needs to be formed of the missions SEI will carry out, near term as well as far, and of the ways in which these missions can mutually support one another. Near term programs should be so constituted as to provide for the long term missions both the enabling technologies and the accumulation of experience they need. In achieving this, missions in Earth orbit should both evolve and show the technologies crucial to long term missions on the lunar surface, and the program for the lunar labs should evolve and show the enabling technologies for exploration of the surface of Mars and for flights of human beings to Mars and return. In the near term, the program for the Space Station should be directed and funded to develop and demonstrate the solar Brayton power plant that will be most useful as the power generator for the SP-100 nuclear reactor.

Evolving the SP-100 reactor in order to boost large payloads to GEO and to low lunar orbit via nuclear-electric propulsion

NASA Technical Reports Server (NTRS)

English, Robert E.

1991-01-01

In striving to reduce exploration cost and exploration risks, a crucial aspect of the plans is program continuity, i.e., the continuing application of a given technology over a long period so that experience will accumulate from extended testing here on earth and from a diversity of applications in space. An integrated view needs to be formed of the missions SEI will carry out, near term as well as far, and of the ways in which these missions can mutually support one another. Near term programs should be so constituted as to provide for the long term missions both the enabling technologies and the accumulation of experience they need. In achieving this, missions in earth orbit should both evolve and show the technologies crucial to long term missions on the lunar surfaces, and the program for the lunar labs should evolve and show the enabling technologies for exploration of the surface of Mars and for flights of human beings to Mars and return. In the near term, the program for the Space Station should be directed and funded to develop and demonstrate the solar Brayton power plant that will be most useful as the power generator for the SP-100 nuclear reactor.

Verification of Autonomous Systems for Space Applications

NASA Technical Reports Server (NTRS)

Brat, G.; Denney, E.; Giannakopoulou, D.; Frank, J.; Jonsson, A.

2006-01-01

Autonomous software, especially if it is based on model, can play an important role in future space applications. For example, it can help streamline ground operations, or, assist in autonomous rendezvous and docking operations, or even, help recover from problems (e.g., planners can be used to explore the space of recovery actions for a power subsystem and implement a solution without (or with minimal) human intervention). In general, the exploration capabilities of model-based systems give them great flexibility. Unfortunately, it also makes them unpredictable to our human eyes, both in terms of their execution and their verification. The traditional verification techniques are inadequate for these systems since they are mostly based on testing, which implies a very limited exploration of their behavioral space. In our work, we explore how advanced V&V techniques, such as static analysis, model checking, and compositional verification, can be used to gain trust in model-based systems. We also describe how synthesis can be used in the context of system reconfiguration and in the context of verification.

The Dust Management Project: Characterizing Lunar Environments and Dust, Developing Regolith Mitigation Technology and Simulants

NASA Technical Reports Server (NTRS)

Hyatt, Mark J.; Straka, Sharon A.

2010-01-01

A return to the Moon to extend human presence, pursue scientific activities, use the Moon to prepare for future human missions to Mars, and expand Earth?s economic sphere, will require investment in developing new technologies and capabilities to achieve affordable and sustainable human exploration. From the operational experience gained and lessons learned during the Apollo missions, conducting long-term operations in the lunar environment will be a particular challenge, given the difficulties presented by the unique physical properties and other characteristics of lunar regolith, including dust. The Apollo missions and other lunar explorations have identified significant lunar dust-related problems that will challenge future mission success. Comprised of regolith particles ranging in size from tens of nanometers to microns, lunar dust is a manifestation of the complex interaction of the lunar soil with multiple mechanical, electrical, and gravitational effects. The environmental and anthropogenic factors effecting the perturbation, transport, and deposition of lunar dust must be studied in order to mitigate it?s potentially harmful effects on exploration systems and human explorers. The Dust Management Project (DMP) is tasked with the evaluation of lunar dust effects, assessment of the resulting risks, and development of mitigation and management strategies and technologies related to Exploration Systems architectures. To this end, the DMP supports the overall goal of the Exploration Technology Development Program (ETDP) of addressing the relevant high priority technology needs of multiple elements within the Constellation Program (CxP) and sister ETDP projects. Project scope, plans, and accomplishments will be presented.

HSI in NASA: From Research to Implementation

NASA Technical Reports Server (NTRS)

Whitmore, Mihriban; Plaga, John A.

2016-01-01

As NASA plans to send human explorers beyond low Earth orbit, onward to Mars and other destinations in the solar system, there will be new challenges to address in terms of HSI. These exploration missions will be quite different from the current and past missions such as Apollo, Shuttle, and International Space Station. The exploration crew will be more autonomous from ground mission control with delayed, and at times, no communication. They will have limited to no resupply for much longer mission durations. Systems to deliver and support extended human habitation at these destinations are extremely complex and unique, presenting new opportunities to employ HSI practices. In order to have an effective and affordable HSI implementation, both research and programmatic efforts are required. Currently, the HSI-related research at NASA is primarily in the area of space human factors and habitability. The purpose is to provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration beyond low Earth orbit, and update standards, requirements, and processes to verify and validate these requirements. In addition, HSI teams are actively engaged in technology development and demonstration efforts to influence the mission architecture and next-generation vehicle design. Finally, appropriate HSI references have been added to NASA' s systems engineering documentation, and an HSI Practitioner's Guide has been published to help design engineers consider HSI early and continuously in the acquisition process. These current and planned HSI-related activities at NASA will be discussed in this panel.

Mars Landing + 50 Years: Repurposing the First Viking Landing Site on Chryse Planitia as an Exploration Zone for Automated Infrastructure Construction

NASA Astrophysics Data System (ADS)

Farrell, K. W.

2015-10-01

The proposed Chryse Planitia EZ centered near the VL-1 landing site has evidence for adequate water ice, silica, and load-bearing bedrock surface resources to utilize as infrastructure for long-term missions to support humans.

Emergence of scaling in human-interest dynamics

PubMed Central

Zhao, Zhi-Dan; Yang, Zimo; Zhang, Zike; Zhou, Tao; Huang, Zi-Gang; Lai, Ying-Cheng

2013-01-01

Human behaviors are often driven by human interests. Despite intense recent efforts in exploring the dynamics of human behaviors, little is known about human-interest dynamics, partly due to the extreme difficulty in accessing the human mind from observations. However, the availability of large-scale data, such as those from e-commerce and smart-phone communications, makes it possible to probe into and quantify the dynamics of human interest. Using three prototypical “Big Data” sets, we investigate the scaling behaviors associated with human-interest dynamics. In particular, from the data sets we uncover fat-tailed (possibly power-law) distributions associated with the three basic quantities: (1) the length of continuous interest, (2) the return time of visiting certain interest, and (3) interest ranking and transition. We argue that there are three basic ingredients underlying human-interest dynamics: preferential return to previously visited interests, inertial effect, and exploration of new interests. We develop a biased random-walk model, incorporating the three ingredients, to account for the observed fat-tailed distributions. Our study represents the first attempt to understand the dynamical processes underlying human interest, which has significant applications in science and engineering, commerce, as well as defense, in terms of specific tasks such as recommendation and human-behavior prediction. PMID:24326949

A Bootstrap Approach to an Affordable Exploration Program

NASA Technical Reports Server (NTRS)

Oeftering, Richard C.

2011-01-01

This paper examines the potential to build an affordable sustainable exploration program by adopting an approach that requires investing in technologies that can be used to build a space infrastructure from very modest initial capabilities. Human exploration has had a history of flight programs that have high development and operational costs. Since Apollo, human exploration has had very constrained budgets and they are expected be constrained in the future. Due to their high operations costs it becomes necessary to consider retiring established space facilities in order to move on to the next exploration challenge. This practice may save cost in the near term but it does so by sacrificing part of the program s future architecture. Human exploration also has a history of sacrificing fully functional flight hardware to achieve mission objectives. An affordable exploration program cannot be built when it involves billions of dollars of discarded space flight hardware, instead, the program must emphasize preserving its high value space assets and building a suitable permanent infrastructure. Further this infrastructure must reduce operational and logistics cost. The paper examines the importance of achieving a high level of logistics independence by minimizing resource consumption, minimizing the dependency on external logistics, and maximizing the utility of resources available. The approach involves the development and deployment of a core suite of technologies that have minimum initial needs yet are able expand upon initial capability in an incremental bootstrap fashion. The bootstrap approach incrementally creates an infrastructure that grows and becomes self sustaining and eventually begins producing the energy, products and consumable propellants that support human exploration. The bootstrap technologies involve new methods of delivering and manipulating energy and materials. These technologies will exploit the space environment, minimize dependencies, and minimize the need for imported resources. They will provide the widest range of utility in a resource scarce environment and pave the way to an affordable exploration program.

Space and Planetary Resources

NASA Astrophysics Data System (ADS)

Abbud-Madrid, Angel

2018-02-01

The space and multitude of celestial bodies surrounding Earth hold a vast wealth of resources for a variety of space and terrestrial applications. The unlimited solar energy, vacuum, and low gravity in space, as well as the minerals, metals, water, atmospheric gases, and volatile elements on the Moon, asteroids, comets, and the inner and outer planets of the Solar System and their moons, constitute potential valuable resources for robotic and human space missions and for future use in our own planet. In the short term, these resources could be transformed into useful materials at the site where they are found to extend mission duration and to reduce the costly dependence from materials sent from Earth. Making propellants and human consumables from local resources can significantly reduce mission mass and cost, enabling longer stays and fueling transportation systems for use within and beyond the planetary surface. Use of finely grained soils and rocks can serve for habitat construction, radiation protection, solar cell fabrication, and food growth. The same material could also be used to develop repair and replacement capabilities using advanced manufacturing technologies. Following similar mining practices utilized for centuries on Earth, identifying, extracting, and utilizing extraterrestrial resources will enable further space exploration, while increasing commercial activities beyond our planet. In the long term, planetary resources and solar energy could also be brought to Earth if obtaining these resources locally prove to be no longer economically or environmentally acceptable. Throughout human history, resources have been the driving force for the exploration and settling of our planet. Similarly, extraterrestrial resources will make space the next destination in the quest for further exploration and expansion of our species. However, just like on Earth, not all challenges are scientific and technological. As private companies start working toward exploiting the resources from asteroids, the Moon, and Mars, an international legal framework is also needed to regulate commercial exploration and the use of space and planetary resources for the benefit of all humanity. These resources hold the secret to unleash an unprecedented wave of exploration and of economic prosperity by utilizing the full potential and value of space. It is up to us humans here on planet Earth to find the best way to use these extraterrestrial resources effectively and responsibly to make this promise a reality.

Hibernation for space travel: Impact on radioprotection

NASA Astrophysics Data System (ADS)

Cerri, Matteo; Tinganelli, Walter; Negrini, Matteo; Helm, Alexander; Scifoni, Emanuele; Tommasino, Francesco; Sioli, Maximiliano; Zoccoli, Antonio; Durante, Marco

2016-11-01

Hibernation is a state of reduced metabolic activity used by some animals to survive in harsh environmental conditions. The idea of exploiting hibernation for space exploration has been proposed many years ago, but in recent years it is becoming more realistic, thanks to the introduction of specific methods to induce hibernation-like conditions (synthetic torpor) in non-hibernating animals. In addition to the expected advantages in long-term exploratory-class missions in terms of resource consumptions, aging, and psychology, hibernation may provide protection from cosmic radiation damage to the crew. Data from over half century ago in animal models suggest indeed that radiation effects are reduced during hibernation. We will review the mechanisms of increased radioprotection in hibernation, and discuss possible impact on human space exploration.

Logistics Needs for Potential Deep Space Mission Scenarios Post Asteroid Crewed Mission

NASA Technical Reports Server (NTRS)

Lopez, Pedro, Jr.

2015-01-01

A deep-space mission has been proposed to identify and redirect an asteroid to a distant retrograde orbit around the moon, and explore it by sending a crew using the Space Launch System and the Orion spacecraft. The Asteroid Redirect Crewed Mission (ARCM), which represents the third segment of the Asteroid Redirect Mission (ARM), could be performed on EM-3 or EM-4 depending on asteroid return date. Recent NASA studies have raised questions on how we could progress from current Human Space Flight (HSF) efforts to longer term human exploration of Mars. This paper will describe the benefits of execution of the ARM as the initial stepping stone towards Mars exploration, and how the capabilities required to send humans to Mars could be built upon those developed for the asteroid mission. A series of potential interim missions aimed at developing such capabilities will be described, and the feasibility of such mission manifest will be discussed. Options for the asteroid crewed mission will also be addressed, including crew size and mission duration.

Mars Field Geology, Biology. and Paleontology Workshop: Summary and Recommendations

NASA Technical Reports Server (NTRS)

Budden, Nancy Ann (Editor)

1998-01-01

Current NASA planning envisions human missions to Mars as early as 2013, on a mission that would send six crew members for a 500-day stay on the surface of Mars. While our understanding of how we would get there and back is fairly mature, the planning for what the crew would do to explore while on the surface for 500 days is less detailed. Mission objectives are to understand the composition and geo- morphology of the martian surface, and to continue to investigate and sample the geologic history of Mars. Special emphasis will focus on exploring for possible biogenic signatures, past or present, and on analyzing pre-biotic chemistry. The purpose of this workshop was to explore the strategies, desired capabilities, skills, and operational realities required to lend success to the first human missions to Mars. Current mission planning dictates that there will be considerable mobility, sampling and analytical capability available to human crews, at a site warranting long-term geologic and possibly biological interest. However, the details of specific capabilities are not yet clearly defined.

Mars Field Geology, Biology, and Paleontology Workshop: Summary and Recommendations

NASA Technical Reports Server (NTRS)

Budden, Nancy Ann (Editor)

1999-01-01

Current NASA planning envisions human missions to Mars as early as 2013, on a mission that would send six crew members for a 500-day stay on the surface of Mars. While our understanding of how we would get there and back is fairly mature, the planning for what the crew would do to explore while on the surface for 500 days is less detailed. Mission objectives are to understand the composition and geo- morphology of the martian surface, and to continue to investigate and sample the geologic history of Mars. Special emphasis will focus on exploring for possible biogenic signatures, past or present, and on analyzing pre-biotic chemistry. The purpose of this workshop was to explore the strategies, desired capabilities, skills, and operational realities required to lend success to the first human missions to Mars. Current mission planning dictates that there will be considerable mobility, sampling and analytical capability available to human crews, at a site warranting long-term geologic and possibly biological interest. However, the details of specific capabilities are not yet clearly defined.

Synthetic Biology as an Enabling Technology for Space Exploration

NASA Technical Reports Server (NTRS)

Rothschild, Lynn J.

2016-01-01

Human exploration off planet is severely limited by the cost of launching materials into space and by re-supply. Thus materials brought from Earth must be light, stable and reliable at destination. Using traditional approaches, a lunar or Mars base would require either transporting a hefty store of metals or heavy manufacturing equipment and construction materials for in situ extraction; both would severely limit any other mission objectives. Long-term human space presence requires periodic replenishment, adding a massive cost overhead. Even robotic missions often sacrifice science goals for heavy radiation and thermal protection. Biology has the potential to solve these problems because life can replicate and repair itself, and perform a wide variety of chemical reactions including making food, fuel and materials. Synthetic biology enhances and expands life's evolved repertoire. Using organisms as feedstock, additive manufacturing through bioprinting will make possible the dream of producing bespoke tools, food, smart fabrics and even replacement organs on demand. This new approach and the resulting novel products will enable human exploration and settlement on Mars, while providing new manufacturing approaches for life on Earth.

Environment Challenges for Exploration of the Moon

NASA Technical Reports Server (NTRS)

Minow, Joseph I.; Blackwell, William C., Jr.; Coffey, Victoria N.; Cooke, William B.; Howard, James W.; Parker, Linda N.; Sharp, John; Schunck, Greg; Suggs. Robert W.; Wang, Joseph W.

2008-01-01

NASA's Constellation Program is designing a new generation of human rated launch and space transportation vehicles to first replace the Space Shuttle fleet, then support develop of a permanent human habitat on the Moon, and ultimately prepare for human exploration of Mars. The ambitious first step beyond low Earth orbit is to develop the infrastructure required for conducting missions to a variety of locations on the lunar surface for periods of a week and establishment of a permanent settlement at one of the lunar poles where crews will serve for periods on the order of approx.200 days. We present an overview of the most challenging aspects of the lunar environment that will need to be addressed when developing transport and habitat infrastructure for long term human presence on the Moon including low temperatures and dusty regolith surfaces, radiation environments due to galactic cosmic rays and solar energetic particles, charging of lunar infrastructure when exposed to lunar plasma environments, and secondary meteor environments generated by primary impacts on the lunar surface.

French Crossings: III. The Smile of the Tiger

PubMed Central

Jones, Colin

2016-01-01

This article continues the theme of ‘French Crossings’ explored in other Presidential Addresses by focussing on the border zone between the human and the animal. The focus is on the allegedly tiger-like character attributed to Maimilien Robespierre, particularly after his fall from power and his execution in 1794. This theme is explored in terms of Thermidorian propaganda, French Revolutionary historiography and the ancient discipline of physiognomy, which was reactivated by Johann-Caspar Lavater in the late eighteenth century and still influential through much of the nineteenth. Robespierre’s animal rather than human status was also held to emerge in his inability to smile or laugh, a significant point also in that the meaning of the smile was changing in the same period. PMID:27630376

Short-term treatment with flumazenil restores long-term object memory in a mouse model of Down syndrome.

PubMed

Colas, Damien; Chuluun, Bayarsaikhan; Garner, Craig C; Heller, H Craig

2017-04-01

Down syndrome (DS) is a common genetic cause of intellectual disability yet no pro-cognitive drug therapies are approved for human use. Mechanistic studies in a mouse model of DS (Ts65Dn mice) demonstrate that impaired cognitive function is due to excessive neuronal inhibitory tone. These deficits are normalized by chronic, short-term low doses of GABA A receptor (GABA A R) antagonists in adult animals, but none of the compounds investigated are approved for human use. We explored the therapeutic potential of flumazenil (FLUM), a GABA A R antagonist working at the benzodiazepine binding site that has FDA approval. Long-term memory was assessed by the Novel Object Recognition (NOR) testing in Ts65Dn mice after acute or short-term chronic treatment with FLUM. Short-term, low, chronic dose regimens of FLUM elicit long-lasting (>1week) normalization of cognitive function in both young and aged mice. FLUM at low dosages produces long lasting cognitive improvements and has the potential of fulfilling an unmet therapeutic need in DS. Copyright © 2017. Published by Elsevier Inc.

An exploration of the perception of time from the perspective of the Science of Unitary Human Beings.

PubMed

Ring, Marcia E

2009-01-01

What is time? The science of unitary human beings describes pandimensional reality as a domain without spatial or temporal attributes. As part of this pandimensional reality, unitary human beings experience time as passing, and involving the past, present, and future. The theory of accelerating evolution describes changes in human and environmental energy fields that are always accelerating and are manifested as differences in the experience of time as being slow, fast, and still. Time, be it measured or experienced, has no meaning in and of itself, but can only be understood in terms of the ever-evolving life process.

Child rights, right to water and sanitation, and human security.

PubMed

Pink, Ross

2012-06-15

The article explores the intersection between child rights, water scarcity, sanitation, and the human security paradigm. The recognition of child rights has been advanced through the 1989 Convention on the Rights of the Child and other international legal instruments, while water rights are increasingly affirmed in international law and through the historic July 2010 United Nations General Assembly resolution that strengthened the legal foundation for water security and human rights. Yet there remains a development gap in terms of child access to clean and secure water sources for basic human development needs. The human security paradigm provides a legal and humanitarian foundation for the extension of child rights related to water and sanitation. Copyright © 2012 Pink.

Issues in protection of human subjects in internet research.

PubMed

Im, Eun-Ok; Chee, Wonshik

2002-01-01

Despite the increasing use of the Internet among nurses, the use of the Internet in nursing research has been rarely discussed and critiqued in terms of issues in protection of human subjects. In this article, issues in protection of human subjects in Internet research are explored by analyzing an Internet study to propose directions for human protection in Internet research. Issues raised through the study include those related to (a) anonymity and confidentiality, (b) security, (c) self-determination and authenticity, (d) full disclosure, and (e) fair treatment. Based on discussion of the five issues, development of standardized guidelines, investigator triangulation, and information sharing are proposed as directions for protection of human subjects in Internet research.

Human Rights Discourse in the Sustainable Development Agenda Avoids Obligations and Entitlements

PubMed Central

Williams, Carmel; Blaiklock, Alison

2016-01-01

Our commentary on Forman et al paper explores their thesis that right to health language can frame global health policy responses. We examined human rights discourse in the outcome documents from three 2015 United Nations (UN) summits and found rights-related terms are used in all three. However, a deeper examination of the discourse finds the documents do not convey the obligations and entitlements of human rights and international human rights law. The documents contain little that can be used to empower the participation of those already left behind and to hold States and the private sector to account for their human rights duties. This is especially worrying in a neoliberal era. PMID:27285518

The linguistic roots of Modern English anatomical terminology.

PubMed

Turmezei, Tom D

2012-11-01

Previous research focusing on Classical Latin and Greek roots has shown that understanding the etymology of English anatomical terms may be beneficial for students of human anatomy. However, not all anatomical terms are derived from Classical origins. This study aims to explore the linguistic roots of the Modern English terminology used in human gross anatomy. By reference to the Oxford English Dictionary, etymologies were determined for a lexicon of 798 Modern English gross anatomical terms from the 40(th) edition of Gray's Anatomy. Earliest traceable language of origin was determined for all 798 terms; language of acquisition was determined for 747 terms. Earliest traceable languages of origin were: Classical Latin (62%), Classical Greek (24%), Old English (7%), Post-Classical Latin (3%), and other (4%). Languages of acquisition were: Classical Latin (42%), Post-Classical Latin (29%), Old English (8%), Modern French (6%), Classical Greek (5%), Middle English (3%), and other (7%). While the roots of Modern English anatomical terminology mostly lie in Classical languages (accounting for the origin of 86% of terms), the anatomical lexicon of Modern English is actually much more diverse. Interesting and perhaps less familiar examples from these languages and the methods by which such terms have been created and absorbed are discussed. The author suggests that awareness of anatomical etymologies may enhance the enjoyment and understanding of human anatomy for students and teachers alike. Copyright © 2012 Wiley Periodicals, Inc.

Robotic lunar exploration: Architectures, issues and options

NASA Astrophysics Data System (ADS)

Mankins, John C.; Valerani, Ernesto; Della Torre, Alberto

2007-06-01

The US ‘vision for space exploration’ articulated at the beginning of 2004 encompasses a broad range of human and robotic space missions, including missions to the Moon, Mars and destinations beyond. It establishes clear goals and objectives, yet sets equally clear budgetary ‘boundaries’ by stating firm priorities, including ‘tough choices’ regarding current major NASA programs. The new vision establishes as policy the goals of pursuing commercial and international collaboration in realizing future space exploration missions. Also, the policy envisions that advances in human and robotic mission technologies will play a key role—both as enabling and as a major public benefit that will result from implementing that vision. In pursuing future international space exploration goals, the exploration of the Moon during the coming decades represents a particularly appealing objective. The Moon provides a unique venue for exploration and discovery—including the science of the Moon (e.g., geological studies), science from the Moon (e.g., astronomical observatories), and science on the Moon (including both basic research, such as biological laboratory science, and applied research and development, such as the use of the Moon as a test bed for later exploration). The Moon may also offer long-term opportunties for utilization—including Earth observing applications and commercial developments. During the coming decade, robotic lunar exploration missions will play a particularly important role, both in their own right and as precursors to later, more ambitious human and robotic exploration and development efforts. The following paper discusses some of the issues and opportunities that may arise in establishing plans for future robotic lunar exploration. Particular emphasis is placed on four specific elements of future robotic infrastructure: Earth Moon in-space transportation systems; lunar orbiters; lunar descent and landing systems; and systems for long-range transport on the Moon.

Risk of Adverse Health Outcomes and Decrements in Performance Due to In-flight Medical Conditions

NASA Technical Reports Server (NTRS)

Antonsen,Erik

2017-01-01

The drive to undertake long-duration space exploration missions at greater distances from Earth gives rise to many challenges concerning human performance under extreme conditions. At NASA, the Human Research Program (HRP) has been established to investigate the specific risks to astronaut health and performance presented by space exploration, in addition to developing necessary countermeasures and technology to reduce risk and facilitate safer, more productive missions in space (NASA Human Research Program 2009). The HRP is divided into five subsections, covering behavioral health, space radiation, habitability, and other areas of interest. Within this structure is the ExMC Element, whose research contributes to the overall development of new technologies to overcome the challenges of expanding human exploration and habitation of space. The risk statement provided by the HRP to the ExMC Element states: "Given that medical conditions/events will occur during human spaceflight missions, there is a possibility of adverse health outcomes and decrements in performance in mission and for long term health" (NASA Human Research Program 2016). Within this risk context, the Exploration Medical Capabilities (ExMC) Element is specifically concerned with establishing evidenced-based methods of monitoring and maintaining astronaut health. Essential to completing this task is the advancement in techniques that identify, prevent, and treat any health threats that may occur during space missions. The ultimate goal of the ExMC Element is to develop and demonstrate a pathway for medical system integration into vehicle and mission design to mitigate the risk of medical issues. Integral to this effort is inclusion of an evidence-based medical and data handling system appropriate for long-duration, exploration-class missions. This requires a clear Concept of Operations, quantitative risk metrics or other tools to address changing risk throughout a mission, and system scoping and system engineering. Because of the novel nature of the risks involved in exploration missions, new and complex ethical challenges are likely to be encountered. This document describes the relevant background and evidence that informs the development of an exploration medical system.

Colonization of Venus

NASA Technical Reports Server (NTRS)

Landis, Geoffrey A.

2003-01-01

Although the surface of Venus is an extremely hostile environment, at about 50 kilometers above the surface the atmosphere of Venus is the most earthlike environment (other than Earth itself) in the solar system. It is proposed here that in the near term, human exploration of Venus could take place from aerostat vehicles in the atmosphere, and that in the long term, permanent settlements could be made in the form of cities designed to float at about fifty kilometer altitude in the atmosphere of Venus.

Spirituality and Early Childhood Special Education: Exploring a "Forgotten" Dimension

ERIC Educational Resources Information Center

Zhang, Kaili

2012-01-01

Spirituality is recognised by many to be an inherent property of the human being. Empirical studies and theoretical literature both suggest that spirituality affects one's quality of life in terms of emotional and physical well-being, relationships, and social inclusion. However, the importance of the spiritual dimension of life is rarely…

SMART Money: Do Financial Incentives Encourage College Students to Study Science?

ERIC Educational Resources Information Center

Evans, Brent J.

2012-01-01

This research examines the short term success of a postsecondary federal financial aid program, the SMART Grant, designed to increase this stock of scientific human capital. An exploration of the success of this program provides the opportunity to address two critically important research questions. Do financial incentives encourage students to…

An organizational model for an international Mars mission (From the 1991 International Space University (ISU) design project)

NASA Technical Reports Server (NTRS)

Stoffel, Wilhelm; Mendell, Wendell W.

1991-01-01

An international Mars mission aimed at designing a long term, multinational program for conducting scientific exploration of Mars and developing and/or validating technology enabling the eventual human settlement on the planet is discussed. Emphasis is placed on political and legal issues of the project.

Impacts of Globalisation on Higher Education Reform in China: A Trend of Decentralisation and Autonomy

ERIC Educational Resources Information Center

Xu, Shihong

2005-01-01

By tracing back the historical context of educational changes, this article explores in detail the impacts of globalisation on China's higher education reform. A trend of decentralisation in both rights and responsibilities is revealed in terms of structural adjustment, human resource exploitation and retention, curriculum development, and…

Management and Maintenance of a Very Large Small Mammal Database in a 25 Year Live-Trapping Study in the Chilean Semiarid Zone

EPA Science Inventory

Long-term ecological research programs represent tremendous investments in human labor and capital. The amount of data generated is staggering and potentially beyond the capacity of most research teams to fully explore. Since the funding of these programs comes predominately fr...

Will the Real Eco-Educator Please Stand Up?

ERIC Educational Resources Information Center

Ross, Janet

This paper examines the long-term impact on public lands of human-powered adventure activities. These activities take individuals into federal- or state-owned wild areas to enjoy backpacking, hiking, camping, and a wide variety of sports. Trends in supply and demand for outdoor opportunities are explored. Factors influencing demand include growing…

Toward Inclusion and Human Unity: Rethinking Dewey's Democratic Community

ERIC Educational Resources Information Center

Peng, Hongmei

2009-01-01

In this article, the author digs into John Dewey's writings to explore his democratic community to better understand the meaning and the value of community. The author begins by considering the connotation of the concept "community," which is distinguished from the more popular term "society" used in ordinary language. Then the author transitions…

Differences between Public and Private Universities' Fields of Study in Argentina

ERIC Educational Resources Information Center

Rabossi, Marcelo Alberto

2011-01-01

The literature on private higher education has identified striking differences between the public and private sectors in terms of fields of study. For example, unlike their public counterparts, private universities have traditionally specialised in the social sciences and humanities. This paper explores the university market in Argentina to see if…

Spontaneous revisitation during visual exploration as a link among strategic behavior, learning, and the hippocampus.

PubMed

Voss, Joel L; Warren, David E; Gonsalves, Brian D; Federmeier, Kara D; Tranel, Dan; Cohen, Neal J

2011-08-02

Effective exploratory behaviors involve continuous updating of sensory sampling to optimize the efficacy of information gathering. Despite some work on this issue in animals, little information exists regarding the cognitive or neural mechanisms for this sort of behavioral optimization in humans. Here we examined a visual exploration phenomenon that occurred when human subjects studying an array of objects spontaneously looked "backward" in their scanning paths to view recently seen objects again. This "spontaneous revisitation" of recently viewed objects was associated with enhanced hippocampal activity and superior subsequent memory performance in healthy participants, but occurred only rarely in amnesic patients with severe damage to the hippocampus. These findings demonstrate the necessity of the hippocampus not just in the aspects of long-term memory with which it has been associated previously, but also in the short-term adaptive control of behavior. Functional neuroimaging showed hippocampal engagement occurring in conjunction with frontocerebellar circuits, thereby revealing some of the larger brain circuitry essential for the strategic deployment of information-seeking behaviors that optimize learning.

An adaptive paradigm for human space settlement

NASA Astrophysics Data System (ADS)

Smith, Cameron M.

2016-02-01

Because permanent space settlement will be multigenerational it will have to be viable on ecological timescales so far unfamiliar to those planning space exploration. Long-term viability will require evolutionary and adaptive planning. Adaptations in the natural world provide many lessons for such planning, but implementing these lessons will require a new, evolutionary paradigm for envisioning and carrying out Earth-independent space settlement. I describe some of these adaptive lessons and propose some cognitive shifts required to implement them in a genuinely evolutionary approach to human space settlement.

Human Mars Landing Site and Impacts on Mars Surface Operations

NASA Technical Reports Server (NTRS)

Bussey, Ben; Hoffman, Stephen J.

2016-01-01

NASA has begun a process to identify and discuss candidate locations where humans could land, live and work on the Martian surface. These locations are referred to as Exploration Zones (EZs). Given current mission concepts, an EZ is a collection of Regions of Interest (ROIs) that are located within approximately 100 kilometers of a centralized landing site. ROIs are areas that are relevant for scientific investigation and/or development/maturation of capabilities and resources necessary for a sustainable human presence. The EZ also contains a landing site and a habitation site that will be used by multiple human crews during missions to explore and utilize the ROIs within the EZ. These candidate EZs will be used by NASA as part of a multi-year process of determining where and how humans could explore Mars. In the near term this process includes: (a) identifying locations that would maximize the potential science return from future human exploration missions, (b) identifying locations with the potential for resources required to support humans, (c) developing concepts and engineering systems needed by future human crews to conduct operations within an EZ, and (d) identifying key characteristics of the proposed candidate EZs that cannot be evaluated using existing data sets, thus helping to define precursor measurements needed in advance of human missions. Existing and future robotic spacecraft will be tasked to gather data from specific Mars surface sites within the representative EZs to support these NASA activities. The proposed paper will describe NASA's initial steps for identifying and evaluating candidate EZs and ROIs. This includes plans for the "First Landing Site/Exploration Zone Workshop for Human Missions to the Surface of Mars" to be held in October 2015 at which proposals for EZs and ROIs will be presented and discussed. It will also include a discussion of how these considerations are (or will be) taken into account as future robotic Mars missions are defined and developed. One or more representative EZs, drawn from similar previous studies involving Mars sites, will be used in the proposed paper to illustrate the process NASA envisions for gathering additional data from robotic precursor missions to assist in making a final selection of an EZ for human crews as well as the steps likely to occur during the buildup of a habitation site. Examples of the systems and operations likely to be used by human crews, assisted by robotic vehicles, to explore the scientific ROIs as well as developing the resource ROIs within the example EZs will be discussed.

Oxygen and Metals Processing on the Moon: Will Materials Science Change Our Future in Space?

NASA Technical Reports Server (NTRS)

Sibille, Laurent; Sadoway, Donald R.

2008-01-01

As part of an In-Situ Resource Utilization infrastructure on the lunar surface, the production of oxygen and metals by various technologies is under development within NASA projects. Such an effort reflects the ambition to change paradigms in space exploration to enable human presence for the long-term. Sustaining such presence involves the acceptance of a new concept in space activities; crews must be able to generate some of their consumables from local resources. The balance between accepting early development risks and reducing long-term mission risks is at the core of the technology development approach. We will present an overview of the technologies involved and present their possible impact on the future of human expansion in the solar system.

Understanding and managing conservation conflicts.

PubMed

Redpath, Steve M; Young, Juliette; Evely, Anna; Adams, William M; Sutherland, William J; Whitehouse, Andrew; Amar, Arjun; Lambert, Robert A; Linnell, John D C; Watt, Allan; Gutiérrez, R J

2013-02-01

Conservation conflicts are increasing and need to be managed to minimise negative impacts on biodiversity, human livelihoods, and human well-being. Here, we explore strategies and case studies that highlight the long-term, dynamic nature of conflicts and the challenges to their management. Conflict management requires parties to recognise problems as shared ones, and engage with clear goals, a transparent evidence base, and an awareness of trade-offs. We hypothesise that conservation outcomes will be less durable when conservationists assert their interests to the detriment of others. Effective conflict management and long-term conservation benefit will be enhanced by better integration of the underpinning social context with the material impacts and evaluation of the efficacy of alternative conflict management approaches. Copyright © 2012 Elsevier Ltd. All rights reserved.

Physical/chemical closed-loop water-recycling

NASA Technical Reports Server (NTRS)

Herrmann, Cal C.; Wydeven, Theodore

1991-01-01

Water needs, water sources, and means for recycling water are examined in terms appropriate to the water quality requirements of a small crew and spacecraft intended for long duration exploration missions. Inorganic, organic, and biological hazards are estimated for waste water sources. Sensitivities to these hazards for human uses are estimated. The water recycling processes considered are humidity condensation, carbon dioxide reduction, waste oxidation, distillation, reverse osmosis, pervaporation, electrodialysis, ion exchange, carbon sorption, and electrochemical oxidation. Limitations and applications of these processes are evaluated in terms of water quality objectives. Computerized simulation of some of these chemical processes is examined. Recommendations are made for development of new water recycling technology and improvement of existing technology for near term application to life support systems for humans in space. The technological developments are equally applicable to water needs on Earth, in regions where extensive water recycling is needed or where advanced water treatment is essential to meet EPA health standards.

Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT.

PubMed

Dakic, Vanja; Minardi Nascimento, Juliana; Costa Sartore, Rafaela; Maciel, Renata de Moraes; de Araujo, Draulio B; Ribeiro, Sidarta; Martins-de-Souza, Daniel; Rehen, Stevens K

2017-10-09

Dimethyltryptamines are entheogenic serotonin-like molecules present in traditional Amerindian medicine recently associated with cognitive gains, antidepressant effects, and changes in brain areas related to attention. Legal restrictions and the lack of adequate experimental models have limited the understanding of how such substances impact human brain metabolism. Here we used shotgun mass spectrometry to explore proteomic differences induced by 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) on human cerebral organoids. Out of the 6,728 identified proteins, 934 were found differentially expressed in 5-MeO-DMT-treated cerebral organoids. In silico analysis reinforced previously reported anti-inflammatory actions of 5-MeO-DMT and revealed modulatory effects on proteins associated with long-term potentiation, the formation of dendritic spines, including those involved in cellular protrusion formation, microtubule dynamics, and cytoskeletal reorganization. Our data offer the first insight about molecular alterations caused by 5-MeO-DMT in human cerebral organoids.

ISRU Technologies for Mars Life Support

NASA Technical Reports Server (NTRS)

Finn, John E.; Sridhar, K. R.

2000-01-01

The primary objectives of the Mars Exploration program are to collect data for planetary science in a quest to answer questions related to Origins, to search for evidence of extinct and extant life, and to expand the human presence in the solar system. The public and political engagement that is critical for support of a Mars exploration program is based on all of these objectives. In order to retain and to build public and political support, it is important for NASA to have an integrated Mars exploration plan, not separate robotic and human plans that exist in parallel or in sequence. The resolution stemming from the current architectural review and prioritization of payloads may be pivotal in determining whether NASA will have such a unified plan and retain public support. There are several potential scientific and technological links between the robotic-only missions that have been flown and planned to date, and the robotic + human missions that will come in the future. Taking advantage of and leveraging those links are central to the idea of a unified Mars exploration plan. One such link is in situ resource utilization (ISRU) as an enabling technology to provide consumables such as fuels, oxygen, sweep and utility gases from the Mars atmosphere. ISRU for propellant production and for generation of life support consumables is a key element of human exploration mission plans because of the tremendous savings that can be realized in terms of launch costs and reduction in overall risk to the mission. The Human Exploration and Development of Space (HEDS) Enterprise has supported ISRU technology development for several years, and is funding the MIP and PROMISE payloads that will serve as the first demonstrations of ISRU technology for Mars. In our discussion and presentation at the workshop, we will highlight how the PROMISE ISRU experiment that has been selected by HEDS for a future Mars flight opportunity can extend and enhance the science experiments on board.

Integrating spaceflight human system risk research

NASA Astrophysics Data System (ADS)

Mindock, Jennifer; Lumpkins, Sarah; Anton, Wilma; Havenhill, Maria; Shelhamer, Mark; Canga, Michael

2017-10-01

NASA is working to increase the likelihood of exploration mission success and to maintain crew health, both during exploration missions and long term after return to Earth. To manage the risks in achieving these goals, a system modelled after a Continuous Risk Management framework is in place. ;Human System Risks; (Risks) have been identified, and 32 are currently being actively addressed by NASA's Human Research Program (HRP). Research plans for each of HRP's Risks have been developed and are being executed. Inter-disciplinary ties between the research efforts supporting each Risk have been identified; however, efforts to identify and benefit from these connections have been mostly ad hoc. There is growing recognition that solutions developed to address the full set of Risks covering medical, physiological, behavioural, vehicle, and organizational aspects of exploration missions must be integrated across Risks and disciplines. This paper discusses how a framework of factors influencing human health and performance in space is being applied as the backbone for bringing together sometimes disparate information relevant to the individual Risks. The resulting interrelated information enables identification and visualization of connections between Risks and research efforts in a systematic and standardized manner. This paper also discusses the applications of the visualizations and insights into research planning, solicitation, and decision-making processes.

Microbial Contamination in the Spacecraft

NASA Technical Reports Server (NTRS)

Pierson, Duane L.

2001-01-01

Spacecraft and space habitats supporting human exploration contain a diverse population of microorganisms. Microorganisms may threaten human habitation in many ways that directly or indirectly impact the health, safety, or performance of astronauts. The ability to produce and maintain spacecraft and space stations with environments suitable for human habitation has been established over 40 years of human spaceflight. An extensive database of environmental microbiological parameters has been provided for short-term (< 20 days) spaceflight by more than 100 missions aboard the Space Shuttle. The NASA Mir Program provided similar data for long-duration missions. Interestingly, the major bacterial and fungal species found in the Space Shuttle are similar to those encountered in the nearly 15-year-old Mir. Lessons learned from both the US and Russian space programs have been incorporated into the habitability plan for the International Space Station. The focus is on preventive measures developed for spacecraft, cargo, and crews. On-orbit regular housekeeping practices complete with visual inspections are essential, along with microbiological monitoring. Risks associated with extended stays on the Moon or a Mars exploration mission will be much greater than previous experiences because of additional unknown variables. The current knowledge base is insufficient for exploration missions, and research is essential to understand the effects of spaceflight on biological functions and population dynamics of microorganisms in spacecraft.

Origins of house mice in ecological niches created by settled hunter-gatherers in the Levant 15,000 y ago

PubMed Central

Weissbrod, Lior; Marshall, Fiona B.; Valla, François R.; Khalaily, Hamoudi; Bar-Oz, Guy; Auffray, Jean-Christophe; Vigne, Jean-Denis; Cucchi, Thomas

2017-01-01

Reductions in hunter-gatherer mobility during the Late Pleistocene influenced settlement ecologies, altered human relations with animal communities, and played a pivotal role in domestication. The influence of variability in human mobility on selection dynamics and ecological interactions in human settlements has not been extensively explored, however. This study of mice in modern African villages and changing mice molar shapes in a 200,000-y-long sequence from the Levant demonstrates competitive advantages for commensal mice in long-term settlements. Mice from African pastoral households provide a referential model for habitat partitioning among mice taxa in settlements of varying durations. The data reveal the earliest known commensal niche for house mice in long-term forager settlements 15,000 y ago. Competitive dynamics and the presence and abundance of mice continued to fluctuate with human mobility through the terminal Pleistocene. At the Natufian site of Ain Mallaha, house mice displaced less commensal wild mice during periods of heavy occupational pressure but were outcompeted when mobility increased. Changing food webs and ecological dynamics in long-term settlements allowed house mice to establish durable commensal populations that expanded with human societies. This study demonstrates the changing magnitude of cultural niche construction with varying human mobility and the extent of environmental influence before the advent of farming. PMID:28348225

Origins of house mice in ecological niches created by settled hunter-gatherers in the Levant 15,000 y ago.

PubMed

Weissbrod, Lior; Marshall, Fiona B; Valla, François R; Khalaily, Hamoudi; Bar-Oz, Guy; Auffray, Jean-Christophe; Vigne, Jean-Denis; Cucchi, Thomas

2017-04-18

Reductions in hunter-gatherer mobility during the Late Pleistocene influenced settlement ecologies, altered human relations with animal communities, and played a pivotal role in domestication. The influence of variability in human mobility on selection dynamics and ecological interactions in human settlements has not been extensively explored, however. This study of mice in modern African villages and changing mice molar shapes in a 200,000-y-long sequence from the Levant demonstrates competitive advantages for commensal mice in long-term settlements. Mice from African pastoral households provide a referential model for habitat partitioning among mice taxa in settlements of varying durations. The data reveal the earliest known commensal niche for house mice in long-term forager settlements 15,000 y ago. Competitive dynamics and the presence and abundance of mice continued to fluctuate with human mobility through the terminal Pleistocene. At the Natufian site of Ain Mallaha, house mice displaced less commensal wild mice during periods of heavy occupational pressure but were outcompeted when mobility increased. Changing food webs and ecological dynamics in long-term settlements allowed house mice to establish durable commensal populations that expanded with human societies. This study demonstrates the changing magnitude of cultural niche construction with varying human mobility and the extent of environmental influence before the advent of farming.

Effects of six priority controlled phthalate esters with long-term low-dose integrated exposure on male reproductive toxicity in rats.

PubMed

Gao, Hai-Tao; Xu, Run; Cao, Wei-Xin; Qian, Liang-Liang; Wang, Min; Lu, Lingeng; Xu, Qian; Yu, Shu-Qin

2017-03-01

Human beings are inevitably exposed to ubiquitous phthalate esters (PEs) surroundings. The purposes of this study were to investigate the effects of long-term low-dose exposure to the mixture of six priority controlled phthalate esters (MIXPs): dimethyl phthalate (DMP), diethyl phthalate (DEP), di(n-butyl) phthalate (DBP), butyl benzyl phthalate (BBP), di(2-ethyhexyl) phthalate (DEHP) and di-n-octyl phthalate (DNOP), on male rat reproductive system and further to explore the underlying mechanisms of the reproductive toxicity. The male rats were orally exposed to either sodium carboxymethyl cellulose as controls or MIXPs at three different low-doses by gavage for 15 weeks. Testosterone and luteinizing hormone (LH) in serum were analyzed, and pathological examinations were performed for toxicity evaluation. Steroidogenic proteins (StAR, P450scc, CYP17A1 and 17β-HSD), cell cycle and apoptosis-related proteins (p53, Chk1, Cdc2, CDK6, Bcl-2 and Bax) were measured for mechanisms exploration. MIXPs with long-term low-dose exposure could cause male reproductive toxicity to the rats, including the decrease of both serum and testicular testosterone, and the constructional damage of testis. These effects were related to down-regulated steroidogenic proteins, arresting cell cycle progression and promoting apoptosis in rat testicular cells. The results indicate that MIXPs with long-term low-dose exposure may pose male reproductive toxicity in human. Copyright © 2017 Elsevier Ltd. All rights reserved.

Why We Explore: The Value of Space Exploration for Future Generations

NASA Technical Reports Server (NTRS)

Cook, Stephen A.; Armstrong, Robert C., Jr.

2007-01-01

The National Aeronautics and Space Administration (NASA) and its industry partners are making measurable progress toward delivering new human space transportation capabilities to serve as the catalyst for a new era of discovery, as directed by the U.S. Vision for Space Exploration. In the interest of ensuring prolonged support, the Agency encourages space advocates of all stripes to accurately portray both the tangible and intangible benefits of space exploration, especially its value for future generations. This may be done not only by emphasizing the nation's return on its aerospace investment, but also by highlighting enabling security features and by promoting the scientific and technological benefits that accrue from the human exploration of space. As America embarks on a new era of leadership and international partnership on the next frontier, we are poised to master space by living off-planet on the Moon to prepare astronauts for longer journeys to Mars. These and other relevant facts should be clearly in the view of influential decision-makers and the American taxpayers, and we must increasingly involve those on whom the long-term sustainability of space exploration ultimately depends: America's youth. This paper will examine three areas of concrete benefits for future generations: fundamental security, economic enterprise, and high-technology advancements spurred by the innovation that scientific discovery demands.

Exploring a novel environment improves motivation and promotes recall of words.

PubMed

Schomaker, Judith; van Bronkhorst, Marthe L V; Meeter, Martijn

2014-01-01

Active exploration of novel environments is known to increase plasticity in animals, promoting long-term potentiation in the hippocampus and enhancing memory formation. These effects can occur during as well as after exploration. In humans novelty's effects on memory have been investigated with other methods, but never in an active exploration paradigm. We therefore investigated whether active spatial exploration of a novel compared to a previously familiarized virtual environment promotes performance on an unrelated word learning task. Exploration of the novel environment enhanced recall, generally thought to be hippocampus-dependent, but not recognition, believed to rely less on the hippocampus. Recall was better for participants that gave higher presence ratings for their experience in the virtual environment. These ratings were higher for the novel compared to the familiar virtual environment, suggesting that novelty increased attention for the virtual rather than real environment; however, this did not explain the effect of novelty on recall.

WiFi-Based Real-Time Calibration-Free Passive Human Motion Detection.

PubMed

Gong, Liangyi; Yang, Wu; Man, Dapeng; Dong, Guozhong; Yu, Miao; Lv, Jiguang

2015-12-21

With the rapid development of WLAN technology, wireless device-free passive human detection becomes a newly-developing technique and holds more potential to worldwide and ubiquitous smart applications. Recently, indoor fine-grained device-free passive human motion detection based on the PHY layer information is rapidly developed. Previous wireless device-free passive human detection systems either rely on deploying specialized systems with dense transmitter-receiver links or elaborate off-line training process, which blocks rapid deployment and weakens system robustness. In the paper, we explore to research a novel fine-grained real-time calibration-free device-free passive human motion via physical layer information, which is independent of indoor scenarios and needs no prior-calibration and normal profile. We investigate sensitivities of amplitude and phase to human motion, and discover that phase feature is more sensitive to human motion, especially to slow human motion. Aiming at lightweight and robust device-free passive human motion detection, we develop two novel and practical schemes: short-term averaged variance ratio (SVR) and long-term averaged variance ratio (LVR). We realize system design with commercial WiFi devices and evaluate it in typical multipath-rich indoor scenarios. As demonstrated in the experiments, our approach can achieve a high detection rate and low false positive rate.

WiFi-Based Real-Time Calibration-Free Passive Human Motion Detection †

PubMed Central

Gong, Liangyi; Yang, Wu; Man, Dapeng; Dong, Guozhong; Yu, Miao; Lv, Jiguang

2015-01-01

With the rapid development of WLAN technology, wireless device-free passive human detection becomes a newly-developing technique and holds more potential to worldwide and ubiquitous smart applications. Recently, indoor fine-grained device-free passive human motion detection based on the PHY layer information is rapidly developed. Previous wireless device-free passive human detection systems either rely on deploying specialized systems with dense transmitter-receiver links or elaborate off-line training process, which blocks rapid deployment and weakens system robustness. In the paper, we explore to research a novel fine-grained real-time calibration-free device-free passive human motion via physical layer information, which is independent of indoor scenarios and needs no prior-calibration and normal profile. We investigate sensitivities of amplitude and phase to human motion, and discover that phase feature is more sensitive to human motion, especially to slow human motion. Aiming at lightweight and robust device-free passive human motion detection, we develop two novel and practical schemes: short-term averaged variance ratio (SVR) and long-term averaged variance ratio (LVR). We realize system design with commercial WiFi devices and evaluate it in typical multipath-rich indoor scenarios. As demonstrated in the experiments, our approach can achieve a high detection rate and low false positive rate. PMID:26703612

Solar System Exploration Augmented by In-Situ Resource Utilization: Human Planetary Base Issues for Mercury and Saturn

NASA Technical Reports Server (NTRS)

Palaszewski, Bryan A.

2017-01-01

Establishing a lunar presence and creating an industrial capability on the Moon may lead to important new discoveries for all of human kind. Historical studies of lunar exploration, in-situ resource utilization (ISRU) and industrialization all point to the vast resources on the Moon and its links to future human and robotic exploration. In references 1 through 9, a broad range of technological innovations are described and analyzed. Figures 1 depicts program planning for future human missions throughout the solar system which included lunar launched nuclear rockets, and future human settlements on the Moon. Figures 2 and 3 present the results for human Mercury missions, including LEO departure masses and round trip Mercury lander masses. Using in-situ resources, the missions become less burdensome to the LEO launch infrastructure. In one example using Mercury derived hydrogen, the LEO mass of the human Mercury missions can be reduced from 2,800 MT to 1,140 MT (Ref. 15). Additional analyses of staging options for human Mercury missions will be presented. Figures 4 shows an option for thermal control for long term in-space cryogenic storage and Figure 5 depicts the potentially deleterious elements emanating from Mercury that must be addressed, respectively. Updated analyses based on the visions presented will be presented. While advanced propulsion systems were proposed in these historical studies, further investigation of nuclear options using high power nuclear thermal and nuclear electric propulsion as well as advanced chemical propulsion can significantly enhance these scenarios. Human bases at Mercury may have to be resupplied from resources from regolith and water resources in permanently shadowed craters at its northern pole.

National Space Biomedical Research Institute Annual Report

NASA Technical Reports Server (NTRS)

2000-01-01

This report summarizes the activities of the National Space Biomedical Research Institute (NSBRI) during FY 2000. The NSBRI is responsible for the development of countermeasures against the deleterious effects of long-duration space flight and performs fundamental and applied space biomedical research directed towards this specific goal. Its mission is to lead a world-class, national effort in integrated, critical path space biomedical research that supports NASA's Human Exploration and Development of Space (HEDS) Strategic Plan by focusing on the enabling of long-term human presence in, development of, and exploration of space. This is accomplished by: designing, testing and validating effective countermeasures to address the biological and environmental impediments to long-term human space flight; defining the molecular, cellular, organ-level, integrated responses and mechanistic relationships that ultimately determine these impediments, where such activity fosters the development of novel countermeasures; establishing biomedical support technologies to maximize human performance in space, reduce biomedical hazards to an acceptable level, and deliver quality medical care; transferring and disseminating the biomedical advances in knowledge and technology acquired through living and working in space to the general benefit of mankind, including the treatment of patients suffering from gravity- and radiation-related conditions on Earth; and ensuring open involvement of the scientific community, industry and the public at large in the Institute's activities and fostering a robust collaboration with NASA, particularly through NASA's Lyndon B. Johnson Space Center. Attachment:Appendices (A,B,C,D,E,F,G,H,I,J,K,L,M,N,O, and P.).

Anti-Urokinase Receptor Antisense Oligonucleotide (uPAR-aODN) to Prevent and Cure Long-Term Space Exploration-Related Retinal Pathological Angiogenesis

NASA Astrophysics Data System (ADS)

Lazzarano, Stefano; Lulli, Matteo; Fibbi, Gabriella; Margheri, Francesca; Papucci, Laura; Serrati, Simona; Witort, Ewa; Chilla, Anastasia; Lapucci, Andrea; Donnini, Martino; Quaglierini, Paolo; Romiti, Alice; Specogna, Rebecca; Del Rosso, Mario; Capaccioli, Sergio

2008-06-01

Angiogenesis underlies a variety of physiological processes and its possible deregulation during long term space exploration needs to be investigated. Angiogenesis is a multistep process of new blood capillary formation, where degradation of the extracellular matrix (ECM) by proteolytic enzymes, including uPA (urokinase plasminogen activator) and opening the way to migration of endothelial cells (EC), is critical. Plasminogen activation system regulates angiogenesis by both uPA-driven ECM degradation and uPA receptor (uPAR). Microgravity and low dose irradiations promote tissue neoangiogeenesis and neovascularization is often common occurence in ophthalmologic pathologies. We have designed and patented the uPAR antisense oligonucleotide (aODN) and evaluated its antiangiogenetic activity by EC cellular migration and capillary morphogenesis assays. The uPAR aODN treatment caused a 75% inhibition of human microvascular EC migration and a complete inhibition of capillary morphogenesis, suggesting its therapeutic application to prevent neoangiogenesis-related ophthalmologic pathologies during space exploration.

Early Instruction in Geography: An Exploration in the Ecology of Kindergarten and First-Grade Geography Education

ERIC Educational Resources Information Center

Walker, Scott L.

2007-01-01

This article presents an introductory study of early-grade level geography education in terms of human ecology using accepted cognitive process and knowledge dimensions related to learning. The central question addressed is "at what cognitive process and knowledge levels do kindergarten and first-grade teachers teach geography?" A tentative answer…

The Effect of Career and Technical Education on Human Capital Accumulation: Causal Evidence from Massachusetts

ERIC Educational Resources Information Center

Dougherty, Shaun M.

2018-01-01

Earlier work demonstrates that career and technical education (CTE) can provide long-term financial benefits to participants, yet few have explored potential academic impacts, with none in the era of high-stakes accountability. This paper investigates the causal impact of participating in a specialized high school-based CTE delivery system on high…

Old friends in new places: exploring the role of extraintestinal E.coli in intestinal disease and foodborne illness

USDA-ARS?s Scientific Manuscript database

The emergence of new antibiotic-resistant Escherichia coli pathotypes associated with human disease has led to an investigation in terms of the origins of these pathogens. According to the Centers for Disease Control and Prevention, unspecified agents are responsible for 38.4 million out of the 48 m...

Cis-Lunar Base Camp

NASA Technical Reports Server (NTRS)

Merrill, Raymond G.; Goodliff, Kandyce E.; Mazanek, Daniel D.; Reeves, John D., Jr.

2012-01-01

Historically, when mounting expeditions into uncharted territories, explorers have established strategically positioned base camps to pre-position required equipment and consumables. These base camps are secure, safe positions from which expeditions can depart when conditions are favorable, at which technology and operations can be tested and validated, and facilitate timely access to more robust facilities in the event of an emergency. For human exploration missions into deep space, cis-lunar space is well suited to serve as such a base camp. The outer regions of cis-lunar space, such as the Earth-Moon Lagrange points, lie near the edge of Earth s gravity well, allowing equipment and consumables to be aggregated with easy access to deep space and to the lunar surface, as well as more distant destinations, such as near-Earth Asteroids (NEAs) and Mars and its moons. Several approaches to utilizing a cis-lunar base camp for sustainable human exploration, as well as some possible future applications are identified. The primary objective of the analysis presented in this paper is to identify options, show the macro trends, and provide information that can be used as a basis for more detailed mission development. Compared within are the high-level performance and cost of 15 preliminary cis-lunar exploration campaigns that establish the capability to conduct crewed missions of up to one year in duration, and then aggregate mass in cis-lunar space to facilitate an expedition from Cis-Lunar Base Camp. Launch vehicles, chemical propulsion stages, and electric propulsion stages are discussed and parametric sizing values are used to create architectures of in-space transportation elements that extend the existing in-space supply chain to cis-lunar space. The transportation options to cis-lunar space assessed vary in efficiency by almost 50%; from 0.16 to 0.68 kg of cargo in cis-lunar space for every kilogram of mass in Low Earth Orbit (LEO). For the 15 cases, 5-year campaign costs vary by only 15% from 0.36 to 0.51 on a normalized scale across all campaigns. Thus the development and first flight costs of assessed transportation options are similar. However, the cost of those options per flight beyond the initial operational capability varies by 70% from 0.3 to 1.0 on a normalized scale. The 10-year campaigns assessed begin to show the effect of this large range of cost beyond initial operational capability as they vary approximately 25% with values from 0.75 to 1.0 on the normalized campaign scale. Therefore, it is important to understand both the cost of implementation and first use as well as long term utilization. Finally, minimizing long term recurring costs is critical to the affordability of future human space exploration missions. Finally minimizing long term recurring costs is critical to the affordability of future human space exploration missions.

Arousal regulation and affective adaptation to human responsiveness by a robot that explores and learns a novel environment.

PubMed

Hiolle, Antoine; Lewis, Matthew; Cañamero, Lola

2014-01-01

In the context of our work in developmental robotics regarding robot-human caregiver interactions, in this paper we investigate how a "baby" robot that explores and learns novel environments can adapt its affective regulatory behavior of soliciting help from a "caregiver" to the preferences shown by the caregiver in terms of varying responsiveness. We build on two strands of previous work that assessed independently (a) the differences between two "idealized" robot profiles-a "needy" and an "independent" robot-in terms of their use of a caregiver as a means to regulate the "stress" (arousal) produced by the exploration and learning of a novel environment, and (b) the effects on the robot behaviors of two caregiving profiles varying in their responsiveness-"responsive" and "non-responsive"-to the regulatory requests of the robot. Going beyond previous work, in this paper we (a) assess the effects that the varying regulatory behavior of the two robot profiles has on the exploratory and learning patterns of the robots; (b) bring together the two strands previously investigated in isolation and take a step further by endowing the robot with the capability to adapt its regulatory behavior along the "needy" and "independent" axis as a function of the varying responsiveness of the caregiver; and (c) analyze the effects that the varying regulatory behavior has on the exploratory and learning patterns of the adaptive robot.

CytoCom: a Cytoscape app to visualize, query and analyse disease comorbidity networks.

PubMed

Moni, Mohammad Ali; Xu, Haoming; Liò, Pietro

2015-03-15

CytoCom is an interactive plugin for Cytoscape that can be used to search, explore, analyse and visualize human disease comorbidity network. It represents disease-disease associations in terms of bipartite graphs and provides International Classification of Diseases, Ninth Revision (ICD9)-centric and disease name centric views of disease information. It allows users to find associations between diseases based on the two measures: Relative Risk (RR) and [Formula: see text]-correlation values. In the disease network, the size of each node is based on the prevalence of that disease. CytoCom is capable of clustering disease network based on the ICD9 disease category. It provides user-friendly access that facilitates exploration of human diseases, and finds additional associated diseases by double-clicking a node in the existing network. Additional comorbid diseases are then connected to the existing network. It is able to assist users for interpretation and exploration of the human diseases by a variety of built-in functions. Moreover, CytoCom permits multi-colouring of disease nodes according to standard disease classification for expedient visualization. © The Author 2014. Published by Oxford University Press.

The Anatomy of Human Trafficking: Learning About the Blues: A Healthcare Provider's Guide.

PubMed

Stevens, Meriam; Berishaj, Kelly

2016-01-01

Human trafficking is a major global public health concern. It is a grave crime that violates human rights. Contrary to healthcare providers' perceptions, victims of human trafficking come in contact with the healthcare system while being trafficked, with the emergency department being the most frequented setting for medical treatment. In this article, we explore the anatomy of human trafficking, including the scope of the problem, definitions, and types and elements of human trafficking. The roles of clinicians, particularly emergency department nurses and advanced practice nurses, in screening and identifying those at risk are examined. Clinical practice tools and guidelines that may be used by clinicians to guide the treatment of human trafficking victims are reviewed. Finally, current strategies and resources that address human trafficking are presented. For the purpose of this article, the terms "human trafficking" or "trafficking" will be used throughout.

Summary of the Report of the U.S. National Research Council's Committee on Human Spaceflight

NASA Astrophysics Data System (ADS)

Moloney, Michael; Graham, Sandra; Angleman, Alan

Human spaceflight is considered by many to be the ultimate human endeavor in space—a pursuit to determine just how far human beings can venture into the cosmos and to understand what it is we will find and what we can do as a species in space. The U.S. National Research Council’s Committee on Human Spaceflight was charged to examine carefully and thoroughly the rationale for and value of human spaceflight in as broad a context as possible. Whereas the financial benefit of the peaceful uses of outer space, such as using space-based assets for communication systems or weather prediction, might be clear and the scientific benefits of the robotic exploration of our cosmos might be compelling, understanding the extent to which the world needs or desires human spaceflight requires a much more nuanced and complex assessment. This paper will focus on this committee’s assessment of these questions and describe the findings and recommendations of the committee’s report—in particular, examining the long-term goals and direction of a sustainable future for human spaceflight. The report, which will be released in Spring 2014, examines the rationales and benefits of human spaceflight—in the context the needs of science, industry, international relations and partnerships, and the public good—and a sustainable pathway approach to human deep space exploration. The talk would present the committee's understanding of the rationales, pathways, and decision rules that could enable and guide future planning of human space exploration. This US-NRC study was requested by the U.S. Congress and supported by the National Aeronautics and Space Administration (NASA). Conducted over 18 months, a committee of experts, drawn from diverse areas of expertise spanning the National Academies system, the study: • Considered the goals for human spaceflight and the expected value of NASA’s human spaceflight activities in the context of national goals, • Solicited broadly-based, but directed, public and stakeholder input to understand better the motivations, goals, and possible evolution of human spaceflight, • Considered how to identify a set of high-priority enduring questions that could provide the rationale for and value of human exploration in a national and international context, and • Reviewed prior national and international studies and reports on human spaceflight.

Lunar Polar In Situ Resource Utilization (ISRU) as a Stepping Stone for Human Exploration

NASA Technical Reports Server (NTRS)

Sanders, Gerald B.

2013-01-01

A major emphasis of NASA is to extend and expand human exploration across the solar system. While specific destinations are still being discussed as to what comes first, it is imperative that NASA create new technologies and approaches that make space exploration affordable and sustainable. Critical to achieving affordable and sustainable exploration beyond low Earth orbit (LEO) are the development of technologies and approaches for advanced robotics, power, propulsion, habitats, life support, and especially, space resource utilization systems. Space resources and how to use them, often called In-Situ Resource Utilization (ISRU), can have a tremendous beneficial impact on robotic and human exploration of the Moon, Mars, Phobos, and Near Earth Objects (NEOs), while at the same time helping to solve terrestrial challenges and enabling commercial space activities. The search for lunar resources, demonstration of extraterrestrial mining, and the utilization of resource-derived products, especially from polar volatiles, can be a stepping stone for subsequent human exploration missions to other destinations of interest due to the proximity of the Moon, complimentary environments and resources, and the demonstration of critical technologies, processes, and operations. ISRU and the Moon: There are four main areas of development interest with respect to finding, obtaining, extracting, and using space resources: Prospecting for resources, Production of mission critical consumables like propellants and life support gases, Civil engineering and construction, and Energy production, storage, and transfer. The search for potential resources and the production of mission critical consumables are the primary focus of current NASA technology and system development activities since they provide the greatest initial reduction in mission mass, cost, and risk. Because of the proximity of the Moon, understanding lunar resources and developing, demonstrating, and implementing lunar ISRU provides a near and early opportunity to perform the following that are applicable to other human exploration mission destinations: Identify and characterize resources, how they are distributed, and the material, location and environment in which they are found; Demonstrate concepts, technologies, and hardware that can reduce the cost and risk of human exploration beyond Earth orbit; Use the Moon for operation experience and mission validation for much longer missions that are farther from Earth Develop and evolve ISRU to support sustained, economical human presence beyond Earth's orbit, including promoting space commercialization As Table 1 depicts, the Moon provides environments and resources applicable to Mars and NEOs. Two lunar ISRU resource and product pathways that have notable synergism with NEO, Phobos/Demos, and Mars ISRU are oxygen/metal extraction from regolith, and water/volatile extraction from lunar polar materials. To minimize the risk of developing and incorporating ISRU into human missions, a phased implementation plan is recommended that starts with prospecting and demonstrating critical technologies on robotic and human missions, then performing pilot scale operations (in non-mission critical roles) to enhance exploration mission capabilities, leading to full utilization of space resources in mission critical roles. Which lunar ISRU pathway is followed will depend on the results of early resource prospecting/proof-ofconcept mission(s), and long-term human exploration plans.

Next Gen NEAR: Near Earth Asteroid Human Robotic Precursor Mission Concept

NASA Technical Reports Server (NTRS)

Rivkin, Andrew S.; Kirby, Karen; Cheng, Andrew F.; Gold, Robert; Kelly, Daniel; Reed, Cheryl; Abell, Paul; Garvin, James; Landis, Rob

2012-01-01

Asteroids have long held the attention of the planetary science community. In particular, asteroids that evolve into orbits near that of Earth, called near-Earth objects (NEO), are of high interest as potential targets for exploration due to the relative ease (in terms of delta V) to reach them. NASA's Flexible Path calls for missions and experiments to be conducted as intermediate steps towards the eventual goal of human exploration of Mars; piloted missions to NEOs are such example. A human NEO mission is a valuable exploratory step beyond the Earth-Moon system enhancing capabilities that surpass our current experience, while also developing infrastructure for future mars exploration capabilities. To prepare for a human rendezvous with an NEO, NASA is interested in pursuing a responsible program of robotic NEO precursor missions. Next Gen NEAR is such a mission, building on the NEAR Shoemaker mission experience at the JHU/APL Space Department, to provide an affordable, low risk solution with quick data return. Next Gen NEAR proposes to make measurements needed for human exploration to asteroids: to demonstrate proximity operations, to quantify hazards for human exploration and to characterize an environment at a near-Earth asteroid representative of those that may be future human destinations. The Johns Hopkins University Applied Physics Laboratory has demonstrated exploration-driven mission feasibility by developing a versatile spacecraft design concept using conventional technologies that satisfies a set of science, exploration and mission objectives defined by a concept development team in the summer of 2010. We will describe the mission concept and spacecraft architecture in detail. Configuration options were compared with the mission goals and objectives in order to select the spacecraft design concept that provides the lowest cost, lowest implementation risk, simplest operation and the most benefit for the mission implementation. The Next Gen NEAR spacecraft was designed to support rendezvous with a range of candidate asteroid targets and could easily be launched with one of several NASA launch vehicles. The Falcon 9 launch vehicle supports a Next Gen NEAR launch to target many near-Earth asteroids under consideration that could be reached with a C3 of 18 km2/sec2 or less, and the Atlas V-401 provides added capability supporting launch to NEAs that require more lift capacity while at the same time providing such excess lift capability that another payload of opportunity could be launch in conjunction with Next Gen NEAR. Next Gen NEAR will measure and interact with the target surface in ways never undertaken at an asteroid, and will prepare for first human precursor mission by demonstrating exploration science operations at an accessible NEO. This flexible mission and spacecraft design concept supports target selection based on upcoming Earth-based observations and also provides opportunities for co-manifest & international partnerships. JHU/APL has demonstrated low cost, low risk, high impact missions and this mission will help to prepare NASA for human NEO exploration by combining the best of NASA s human and robotic exploration capabilities.

The path of least resistance: paying for antibiotics in non-human uses.

PubMed

Hollis, Aidan; Ahmed, Ziana

2014-11-01

Antibiotic resistance is a critical threat to human and animal health. Despite the importance of antibiotics, regulators continue to allow antibiotics to be used in low-value applications--subtherapeutic dosing in animals, and spraying tobacco plants for blue mold, for example--where the benefits are unlikely to outweigh the costs in terms of increased resistance. We explore the application of a user fee in non-human uses of antibiotics. Such a fee would efficiently deter low value uses while also providing funding to support the development of the urgently needed new antibiotics. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Synthetic biology meets bioprinting: enabling technologies for humans on Mars (and Earth)

PubMed Central

Rothschild, Lynn J.

2016-01-01

Human exploration off planet is severely limited by the cost of launching materials into space and by re-supply. Thus materials brought from Earth must be light, stable and reliable at destination. Using traditional approaches, a lunar or Mars base would require either transporting a hefty store of metals or heavy manufacturing equipment and construction materials for in situ extraction; both would severely limit any other mission objectives. Long-term human space presence requires periodic replenishment, adding a massive cost overhead. Even robotic missions often sacrifice science goals for heavy radiation and thermal protection. Biology has the potential to solve these problems because life can replicate and repair itself, and perform a wide variety of chemical reactions including making food, fuel and materials. Synthetic biology enhances and expands life's evolved repertoire. Using organisms as feedstock, additive manufacturing through bioprinting will make possible the dream of producing bespoke tools, food, smart fabrics and even replacement organs on demand. This new approach and the resulting novel products will enable human exploration and settlement on Mars, while providing new manufacturing approaches for life on Earth. PMID:27528764

Integrating Spaceflight Human System Risk Research

NASA Technical Reports Server (NTRS)

Mindock, J.; Lumpkins, S.; Anton, W.; Havenhill, M.; Shelhamer, M.; Canga, M.

2016-01-01

NASA is working to increase the likelihoods of human health and performance success during exploration missions, and subsequent crew long-term health. To manage the risks in achieving these goals, a system modeled after a Continuous Risk Management framework is in place. "Human System Risks" (Risks) have been identified, and approximately 30 are being actively addressed by NASA's Human Research Program (HRP). Research plans for each of HRP's Risks have been developed and are being executed. Ties between the research efforts supporting each Risk have been identified, however, this has been in an ad hoc fashion. There is growing recognition that solutions developed to address the full set of Risks covering medical, physiological, behavioral, vehicle, and organizational aspects of the exploration missions must be integrated across Risks and disciplines. We will discuss how a framework of factors influencing human health and performance in space is being applied as the backbone for bringing together sometimes disparate information relevant to the individual Risks. The resulting interrelated information is allowing us to identify and visualize connections between Risks and research efforts in a systematic and standardized way. We will discuss the applications of the visualizations and insights to research planning, solicitation, and decision-making processes.

Exploring the impact of staff absenteeism on patient satisfaction using routine databases in a university hospital.

PubMed

Duclay, E; Hardouin, J B; Sébille, V; Anthoine, E; Moret, L

2015-10-01

To explore the influence of staff absenteeism on patient satisfaction using the indicators available in management reports. Among factors explaining patient satisfaction, human resource indicators have been studied widely in terms of burnout or job satisfaction, but there have not been many studies related to absenteeism indicators. A multilevel analysis was conducted using two routinely compiled databases from 2010 in the clinical departments of a university hospital (France). The staff database monitored absenteeism for short-term medical reasons (5 days or less), non-medical reasons and absences starting at the weekend. The patient satisfaction database was established at the time of discharge. Patient satisfaction related to relationships with staff was significantly and negatively correlated with nurse absenteeism for non-medical reasons (P < 0.05) and with nurse absenteeism starting at weekends (P < 0.05). Patient satisfaction related to the hospital environment was significantly and negatively correlated with nurse assistant absenteeism for short-term medical reasons (P < 0.05). Our findings seem to indicate that patient satisfaction is linked to staff absenteeism and should lead to a better understanding of the impact of human resources on patient satisfaction. To enhance patient satisfaction, managers need to find a way to reduce staff absenteeism, in order to avoid burnout and to improve the atmosphere in the workplace. © 2014 John Wiley & Sons Ltd.

National Aeronautics and Space Administration (NASA) Environmental Control and Life Support (ECLS) Integrated Roadmap Development

NASA Technical Reports Server (NTRS)

Metcalf, Jordan; Peterson, Laurie; Carrasquillo, Robyn; Bagdigian, Robert

2012-01-01

Although NASA is currently considering a number of future human space exploration mission concepts, detailed mission requirements and vehicle architectures remain mostly undefined, making technology investment strategies difficult to develop and sustain without a top-level roadmap to serve as a guide. This paper documents the process and results of an effort to define a roadmap for Environmental Control and Life Support Systems (ECLSS) capabilities required to enhance the long-term operation of the International Space Station (ISS) as well as enable beyond-Low Earth Orbit (LEO) human exploration missions. Three generic mission types were defined to serve as a basis for developing a prioritized list of needed capabilities and technologies. Those are 1) a short duration micro-gravity mission; 2) a long duration microgravity mission; and 3) a long duration partial gravity (surface) exploration mission. To organize the effort, a functional decomposition of ECLSS was completed starting with the three primary functions: atmosphere, water, and solid waste management. Each was further decomposed into sub-functions to the point that current state-of-the-art (SOA) technologies could be tied to the sub-function. Each technology was then assessed by NASA subject matter experts as to its ability to meet the functional needs of each of the three mission types. When SOA capabilities were deemed to fall short of meeting the needs of one or more mission types, those gaps were prioritized in terms of whether or not the corresponding capabilities enable or enhance each of the mission types. The result was a list of enabling and enhancing capability needs that can be used to guide future ECLSS development, as well as a list of existing hardware that is ready to go for exploration-class missions. A strategy to fulfill those needs over time was then developed in the form of a roadmap. Through execution of this roadmap, the hardware and technologies intended to meet exploration needs will, in many cases, directly benefit the ISS operational capability, benefit the Multi-Purpose Crew Vehicle (MPCV), and guide long-term technology investments for longer duration missions.

National Aeronautics and Space Administration (NASA) Environmental Control and Life Support (ECLS) Integrated Roadmap Development

NASA Technical Reports Server (NTRS)

Metcalf, Jordan; Peterson, Laurie; Carrasquillo, Robyn; Bagdigian, Robert

2011-01-01

At present, NASA has considered a number of future human space exploration mission concepts . Yet, detailed mission requirements and vehicle architectures remain mostly undefined, making technology investment strategies difficult to develop and sustain without a top-level roadmap to serve as a guide. This paper documents a roadmap for development of Environmental Control and Life Support Systems (ECLSS) capabilities required to enhance the long-term operation of the International Space Station (ISS) as well as enable beyond-Low Earth Orbit (LEO) human exploration missions. Three generic mission types were defined to serve as a basis for developing a prioritized list of needed capabilities and technologies. Those are 1) a short duration micro gravity mission; 2) a long duration transit microgravity mission; and 3) a long duration surface exploration mission. To organize the effort, ECLSS was categorized into three major functional groups (atmosphere, water, and solid waste management) with each broken down into sub-functions. The ability of existing state-of-the-art (SOA) technologies to meet the functional needs of each of the three mission types was then assessed by NASA subject matter experts. When SOA capabilities were deemed to fall short of meeting the needs of one or more mission types, those gaps were prioritized in terms of whether or not the corresponding capabilities enable or enhance each of the mission types. The result was a list of enabling and enhancing capabilities needs that can be used to guide future ECLSS development, as well as a list of existing hardware that is ready to go for exploration-class missions. A strategy to fulfill those needs over time was then developed in the form of a roadmap. Through execution of this roadmap, the hardware and technologies intended to meet exploration needs will, in many cases, directly benefit the ISS operational capability, benefit the Multi-Purpose Crew Vehicle (MPCV), and guide long-term technology investments for longer duration missions The final product of this paper is an agreed-to ECLSS roadmap detailing ground and flight testing to support the three mission scenarios previously mentioned. This information will also be used to develop the integrated NASA budget submit in January 2012.

Chronic stress impairs spatial memory and motivation for reward without disrupting motor ability and motivation to explore.

PubMed

Kleen, Jonathan K; Sitomer, Matthew T; Killeen, Peter R; Conrad, Cheryl D

2006-08-01

This study uses an operant, behavioral model to assess the daily changes in the decay rate of short-term memory, motivation, and motor ability in rats exposed to chronic restraint. Restraint decreased reward-related motivation by 50% without altering memory decay rate or motor ability. Moreover, chronic restraint impaired hippocampal-dependent spatial memory on the Y maze (4-hr delay) and produced CA3 dendritic retraction without altering hippocampal-independent maze navigation (1-min delay) or locomotion. Thus, mechanisms underlying motivation for food reward differ from those underlying Y maze exploration, and neurobiological substrates of spatial memory, such as the hippocampus, differ from those that underlie short-term memory. Chronic restraint produces functional, neuromorphological, and physiological alterations that parallel symptoms of depression in humans. Copyright 2006 APA, all rights reserved.

Hibernation for space travel: Impact on radioprotection.

PubMed

Cerri, Matteo; Tinganelli, Walter; Negrini, Matteo; Helm, Alexander; Scifoni, Emanuele; Tommasino, Francesco; Sioli, Maximiliano; Zoccoli, Antonio; Durante, Marco

2016-11-01

Hibernation is a state of reduced metabolic activity used by some animals to survive in harsh environmental conditions. The idea of exploiting hibernation for space exploration has been proposed many years ago, but in recent years it is becoming more realistic, thanks to the introduction of specific methods to induce hibernation-like conditions (synthetic torpor) in non-hibernating animals. In addition to the expected advantages in long-term exploratory-class missions in terms of resource consumptions, aging, and psychology, hibernation may provide protection from cosmic radiation damage to the crew. Data from over half century ago in animal models suggest indeed that radiation effects are reduced during hibernation. We will review the mechanisms of increased radioprotection in hibernation, and discuss possible impact on human space exploration. Copyright © 2016 The Committee on Space Research (COSPAR). Published by Elsevier Ltd. All rights reserved.

An exploration of the effectiveness of artificial mini-magnetospheres as a potential Solar Storm shelter for long term human space missions

NASA Astrophysics Data System (ADS)

Bamford, Ruth; Kellett, Barry; Bradford, John; Todd, Tom N.; Stafford-Allen, Robin; Alves, E. Paulo; Silva, Luis; Collingwood, Cheryl; Crawford, Ian A.; Bingham, Robert

2014-12-01

In this paper we explore the effectiveness of an artificial mini-magnetosphere as a potential radiation shelter for long term human space missions. Our study includes the differences that the plasma environment makes to the efficiency of the shielding from the high energy charged particle component of solar and cosmic rays, which radically alters the power requirements. The incoming electrostatic charges are shielded by fields supported by the self captured environmental plasma of the solar wind, potentially augmented with additional density. The artificial magnetic field generated on board acts as the means of confinement and control. Evidence for similar behaviour of electromagnetic fields and ionised particles in interplanetary space can be gained by the example of the enhanced shielding effectiveness of naturally occurring "mini-magnetospheres" on the moon. The shielding effect of surface magnetic fields of the order of ~100s nanoTesla is sufficient to provide effective shielding from solar proton bombardment that culminate in visible discolouration of the lunar regolith known as "lunar swirls". Supporting evidence comes from theory, laboratory experiments and computer simulations that have been obtained on this topic. The result of this work is, hopefully, to provide the tools for a more realistic estimation of the resources versus effectiveness and risk that spacecraft engineers need to work with in designing radiation protection for long-duration human space missions.

Robots and Humans: Synergy in Planetary Exploration

NASA Technical Reports Server (NTRS)

Landis, Geoffrey A.

2003-01-01

How will humans and robots cooperate in future planetary exploration? Are humans and robots fundamentally separate modes of exploration, or can humans and robots work together to synergistically explore the solar system? It is proposed that humans and robots can work together in exploring the planets by use of telerobotic operation to expand the function and usefulness of human explorers, and to extend the range of human exploration to hostile environments.

Robots and Humans: Synergy in Planetary Exploration

NASA Technical Reports Server (NTRS)

Landis, Geoffrey A.

2002-01-01

How will humans and robots cooperate in future planetary exploration? Are humans and robots fundamentally separate modes of exploration, or can humans and robots work together to synergistically explore the solar system? It is proposed that humans and robots can work together in exploring the planets by use of telerobotic operation to expand the function and usefulness of human explorers, and to extend the range of human exploration to hostile environments.

The NASA Bed Rest Project

NASA Technical Reports Server (NTRS)

Rhodes, Bradley; Meck, Janice

2005-01-01

NASA s National Vision for Space Exploration includes human travel beyond low earth orbit and the ultimate safe return of the crews. Crucial to fulfilling the vision is the successful and timely development of countermeasures for the adverse physiological effects on human systems caused by long term exposure to the microgravity environment. Limited access to in-flight resources for the foreseeable future increases NASA s reliance on ground-based analogs to simulate these effects of microgravity. The primary analog for human based research will be head-down bed rest. By this approach NASA will be able to evaluate countermeasures in large sample sizes, perform preliminary evaluations of proposed in-flight protocols and assess the utility of individual or combined strategies before flight resources are requested. In response to this critical need, NASA has created the Bed Rest Project at the Johnson Space Center. The Project establishes the infrastructure and processes to provide a long term capability for standardized domestic bed rest studies and countermeasure development. The Bed Rest Project design takes a comprehensive, interdisciplinary, integrated approach that reduces the resource overhead of one investigator for one campaign. In addition to integrating studies operationally relevant for exploration, the Project addresses other new Vision objectives, namely: 1) interagency cooperation with the NIH allows for Clinical Research Center (CRC) facility sharing to the benefit of both agencies, 2) collaboration with our International Partners expands countermeasure development opportunities for foreign and domestic investigators as well as promotes consistency in approach and results, 3) to the greatest degree possible, the Project also advances research by clinicians and academia alike to encourage return to earth benefits. This paper will describe the Project s top level goals, organization and relationship to other Exploration Vision Projects, implementation strategy, address Project deliverables, schedules and provide a status of bed rest campaigns presently underway.

An Algorithm for the Transport of Anisotropic Neutrons

NASA Technical Reports Server (NTRS)

Tweed, J.

2005-01-01

One major obstacle to human space exploration is the possible limitations imposed by the adverse effect of long-term exposure to the space environment. Even before human spaceflight began, the potentially brief exposure of astronauts to the very intense random solar particle events (SPE) were of great concern. A new challenge appears in deep space exploration from exposure to the low-intensity heavy-ion flux of the galactic cosmic rays (GCR) since the missions are of long duration and the accumulated GCR exposures can be high. Because cancer induction rates increase behind low to rather large thicknesses of aluminum shielding, according to available biological data on mammalian exposures to GCR like ions, the shield requirements for a Mars mission are prohibitively expensive in terms of mission launch costs. Therefore, a critical issue in the Human Exploration and Development of Space enterprise is cost effective mitigation of risk associated with ionizing radiation exposure. In order to estimate astronaut risk to GCR exposure and associated cancer risks and health hazards, it is necessary to do shield material studies. To determine an optimum radiation shield material it is necessary to understand nuclear interaction processes such as fragmentation and secondary particle production which is a function of energy dependent cross sections. This requires knowledge of material transmission characteristics either through laboratory testing or improved theoretical modeling. Here ion beam transport theory is of importance in that testing of materials in the laboratory environment generated by particle accelerators is a necessary step in materials development and evaluation for space use. The approximations used in solving the Boltzmann transport equation for the space setting are often not sufficient for laboratory work and those issues are a major emphasis of the present work.

Hierarchical Partitioning of Metazoan Protein Conservation Profiles Provides New Functional Insights

PubMed Central

Witztum, Jonathan; Persi, Erez; Horn, David; Pasmanik-Chor, Metsada; Chor, Benny

2014-01-01

The availability of many complete, annotated proteomes enables the systematic study of the relationships between protein conservation and functionality. We explore this question based solely on the presence or absence of protein homologues (a.k.a. conservation profiles). We study 18 metazoans, from two distinct points of view: the human's and the fly's. Using the GOrilla gene ontology (GO) analysis tool, we explore functional enrichment of the “universal proteins”, those with homologues in all 17 other species, and of the “non-universal proteins”. A large number of GO terms are strongly enriched in both human and fly universal proteins. Most of these functions are known to be essential. A smaller number of GO terms, exhibiting markedly different properties, are enriched in both human and fly non-universal proteins. We further explore the non-universal proteins, whose conservation profiles are consistent with the “tree of life” (TOL consistent), as well as the TOL inconsistent proteins. Finally, we applied Quantum Clustering to the conservation profiles of the TOL consistent proteins. Each cluster is strongly associated with one or a small number of specific monophyletic clades in the tree of life. The proteins in many of these clusters exhibit strong functional enrichment associated with the “life style” of the related clades. Most previous approaches for studying function and conservation are “bottom up”, studying protein families one by one, and separately assessing the conservation of each. By way of contrast, our approach is “top down”. We globally partition the set of all proteins hierarchically, as described above, and then identify protein families enriched within different subdivisions. While supporting previous findings, our approach also provides a tool for discovering novel relations between protein conservation profiles, functionality, and evolutionary history as represented by the tree of life. PMID:24594619

Refining the Ares V Design to Carry Out NASA's Exploration Initiative

NASA Technical Reports Server (NTRS)

Creech, Steve

2008-01-01

NASA's Ares V cargo launch vehicle is part of an overall architecture for u.S. space exploration that will span decades. The Ares V, together with the Ares I crew launch vehicle, Orion crew exploration vehicle and Altair lunar lander, will carry out the national policy goals of retiring the Space Shuttle, completing the International Space Station program, and expanding exploration of the Moon as a steps toward eventual human exploration of Mars. The Ares fleet (Figure 1) is the product of the Exploration Systems Architecture study which, in the wake of the Columbia accident, recommended separating crew from cargo transportation. Both vehicles are undergoing rigorous systems design to maximize safety, reliability, and operability. They take advantage of the best technical and operational lessons learned from the Apollo, Space Shuttle and more recent programs. NASA also seeks to maximize commonality between the crew and cargo vehicles in an effort to simplify and reduce operational costs for sustainable, long-term exploration.

A Revolution in the Making: Advances in Materials That May Transform Future Exploration Infrastructures and Missions

NASA Technical Reports Server (NTRS)

Harris, Charles E.; Dicus, Dennis L.; Shuart, Mark J.

2001-01-01

The NASA Strategic Plan identifies the long-term goal to provide safe and affordable space access, orbital transfer, and interplanetary transportation capabilities to enable research, human exploration, and the commercial development of space; and to conduct human and robotic missions to planets and other bodies in our solar system. Numerous scientific and engineering breakthroughs will be required to develop the technology necessary to achieve this goal. Critical technologies include advanced vehicle primary and secondary structure, radiation protection, propulsion and power systems, fuel storage, electronics and devices, sensors and science instruments, and medical diagnostics and treatment. Advanced materials with revolutionary new capabilities are an essential element of each of these technologies. This paper discusses those materials best suited for aerospace vehicle structure and highlights the enormous potential of one revolutionary new material, carbon nanotubes.

Options for the human settlement of the moon and Mars

NASA Technical Reports Server (NTRS)

Fairchild, Kyle O.; Roberts, Barney B.

1989-01-01

The evolutionary approach to space development is discussed in the framework of three overall strategies encompassing four case studies. The first strategy, human expeditions, places emphasis on highly visible, near-term manned missions to Mars or to one of the two moons of Mars. These expeditions are similar in scope and objectives to the Apollo program, with infrastructure development only conducted to the degree necessary to support one or two short-duration trips. Two such expeditionary scenarios, one to Phobus and the other to the Mars surface, are discussed. The second strategy involves the construction of science outposts, and emphasizes scientific exploration as well as investigation of technologies and operations needed for permanent habitation. A third strategy, evolutionary expansion, would explore and settle the inner solar system in a series of steps, with continued development of technologies, experience, and infrastructure.

The Possibilities and Challenges in Missions to Europa and Titan for Exploration and as a Stepping Stone to Mankind

NASA Astrophysics Data System (ADS)

Ganapathy, Rohan M.

This enthusiastic project describes a long-term development plan to enable human exploration of the outer solar system, with a focus on Europa and Titan. These are two of the most interesting moons of Jupiter and Saturn, respectively, because they are the places in the solar system with the greatest potential for harboring extraterrestrial life. Since human expeditions to these worlds are considered impossible with current capabilities, the proposal of a well-organized sequence of steps towards making this a reality is formulated. The project includes the necessary development strategies in key scientic and technological areas that are essential for identifying the requirements for the exploration of the outer planetary moons. Some of the topics that are analyzed throughout the project plan include: scientic observations at Europa and Titan, advanced propulsion and nuclear power systems, in-situ resource utilization, radiation mitigation techniques, closed life support systems, habitation for long-term space flight, and artificial gravity. In addition to the scientic and technological aspects of this project, it is recognized that before any research and development work may begin, some level of program management must be established. Within this paper, legal issues, national and international policy, motivation, organization and management, economic considerations, outreach, education, ethics, and social implications are all considered with respect to possible future scenarios which enable human missions to the outer solar system. This project illustrates how such accomplishments could influence a mission to Europa to search for evidence of life in its subsurface oceans. The future remains unpredictable, as does the realization of any of these possibilities. However, projects such as this remind us that the final frontier for humans is truly outer space, and only our imagination will determine where the frontier stops. We can dream of visiting other planetary systems and perhaps even galaxies, but we must begin closer, and considering the scope of our known universe, Europa and Titan are very close indeed.

Return to the Moon: A New Strategic Evaluation

NASA Technical Reports Server (NTRS)

Lowman, Paul D., Jr.

1999-01-01

This paper reviews the value of a new lunar program, initially robotic and eventually manned, in the light of developments since the 1991 Synthesis Group study of the Space Exploration Initiative. The objective is to evaluate a return to the Moon in comparison to proposed Mars programs as a focus for American space exploration with humans in the next century. The Moon is demonstrably accessible, hospitable, useful, and interesting. Lunar programs are inherently faster and less risky from a programmatic viewpoint than comparable Mars programs such as Mars Direct. The dominant reason for a resumption of manned lunar missions, focussed on a single site such as Grimaldi, is to rebuild the infrastructure for missions beyond earth orbit, the last of which was in 1972. A transitional program, corresponding to the 10 Gemini missions that bridged the gap between Mercury and Apollo, was considered absolutely essential by the Synthesis Group. Further justification for a return to the Moon is the demonstrated feasibility of a robotic lunar observatory, concentrating on optical and infrared interferometry. Many unsolved scientific questions about the Moon itself remain, and could be investigated using telerobotic lunar rovers even before the return of humans. Mars is unquestionably more interesting scientifically and far more hospitable for long-term colonization. A new lunar program would be the most effective possible preparation for the human exploration, settlement, and eventually the terraforming of Mars. Lunar and Mars programs are complementary, not competitive. Both can be justified in the most fundamental terms as beginning the dispersal of the human species against uncontrollable natural disasters, cometary or asteroidal impacts in particular, to which mankind is vulnerable while confined to a single planet. Three specific programs are recommended for the 2001-2010 period: Ice Prospectors, to evaluate polar ice or hydrogen deposits; a robotic lunar observatory; and a manned lunar base and observatory.

Return to the Moon: A New Strategic Evaluation

NASA Technical Reports Server (NTRS)

Lowman, Paul D., Jr.

1999-01-01

This paper reviews the value of a new lunar program, initially robotic and eventually manned, in the light of developments since the 1991 Synthes Group study of the Space Exploration Initiative. The objective is to evaluate a return to the Moon in comparison to proposed Mars programs as a focus for American space exploration with humans in the next century. The Moon is demonstrably accessible, hospitable, useful, and interesting. Lunar programs are inherently faster and less risky from a programmatic viewpoint than comparable Mars programs such as Mars Direct. The dominant reason for a resumption of manned lunar missions, focused on a single site such as Grimaldi, is to rebuild the infrastructure for missions beyond Earth orbit, the last of which was in 1972. A transitional prograrr@ corresponding to the 10 Gemini missions that bridged the gap between Mercury and Apollo, was considered absolutely essential by the Synthesis Group. Further justification for a return to the Moon is the demonstrated feasibility of a robotic lunar observatory, concentrating on optical and infrared interferometry. Many unsolved scientific questions about the Moon itself remain, and could be investigated using telerobotic lunar rovers even before the return of humans. Mars is unquestionably more interesting scientifically and far more hospitable for long-term colonization. A new lunar program would be the most effective possible preparation for the human exploration, settlement and eventually the terraforming of Mars. Lunar and Mars programs are complementary, not competitive. Both can be justified in the most fundamental terms as beginning the dispersal of the human species against uncontrollable natural disasters, cometary or asteroidal impacts in particular, to which mankind is vulnerable while confined to a single planet. Three specific programs are recommended for the 2001-2010 period: Ice Prospectors, to evaluate polar ice or hydrogen deposits; a robotic lunar observatory; and a manned lunar base and observatory.

Return to the Moon: A New Strategic Evaluation

NASA Technical Reports Server (NTRS)

Lowman, Paul D., Jr.

1999-01-01

This paper reviews the value of a new lunar program, initially robotic and eventually manned, in the light of developments since the 1991 Synthes Group study of the Space Exploration Initiative. The objective is to evaluate a return to the Moon in comparison to proposed Mars programs as a focus for American space exploration with humans in the next century. The Moon is demonstrably accessible, hospitable, useful, and interesting. Lunar programs are inherently faster and less risky from a programmatic viewpoint than comparable Mars programs such as Mars Direct. The dominant reason for a resumption of manned lunar missions, focused on a single site such as Grimaldi, is to rebuild the infrastructure for missions beyond Earth orbit, the last of which was in 1972. A transitional program, corresponding to the 10 Gemini missions that bridged the gap between Mercury and Apollo, was considered absolutely essential by the Synthesis Group. Further justification for a return to the Moon is the demonstrated feasibility of a robotic lunar observatory, concentrating on optical and infrared interferometry. Many unsolved scientific questions about the Moon itself remain, and could be investigated using telerobotic lunar rovers even before the return of humans. Mars is unquestionably more interesting scientifically and far more hospitable for long-term colonization. A new lunar program would be the most effective possible preparation for the human exploration, settlement and eventually the terraforming of Mars. Lunar and Mars programs are complementary, not competitive. Both can be justified in the most fundamental terms as beginning the dispersal of the human species against uncontrollable natural disasters, cometary or asteroidal impacts in particular, to which mankind is vulnerable while confined to a single planet. Three specific programs are recommended for the 2001-2010 period: Ice Prospectors, to evaluate polar ice or hydrogen deposits; a robotic lunar observatory; and a manned lunar base and observatory.

ISRU Development Strategy and Recent Activities to Support Near and Far Term Missions

NASA Astrophysics Data System (ADS)

Baird, Russell S.; Sanders, Gerald B.; Simon, Thomas M.

2003-01-01

The practical expansion of humans beyond low Earth orbit into near-Earth space and out into the solar system for exploration, commercialization, tourism, and colonization will require the effective utilization of whatever indigenous resources are available to make these endeavors economically feasible and capable of extended operations. This concept of ``living off the land'' is called In-Situ Resource Utilization (ISRU). The resources available for ISRU applications vary widely, depending upon the location. However, there are resources, technologies, and processes that are common to multiple destinations and ISRU-related applications. These resources range from carbon dioxide (CO2) and water vapor found in human habitats (surface & spacecraft) and in the Martian atmosphere, to water (ice and hydrated minerals) and various oxygen, carbon, and metal-bearing resources found on comets and asteroids, and in planetary surface materials at numerous destinations of interest (Moon, Mars, Titan, and Europa). Many parties are investigating the common technologies and processes to effectively extract and use these resources. This paper will discuss how ISRU is enabling for both near and far term human exploration missions, and present a summary of recent and on-going ISRU work sponsored by the NASA/Johnson Space Center. Technology development activities that will be described in detail include an advanced CO2 freezer acquisition system, a multi-fluid common bulkhead cryogenic storage tank, and a variety of microchannel chemical reactor concepts. Recent advanced Sabatier reactor concept development activities in preparation for later, end-to-end system testing will be described as well. This paper will also discuss an ISRU-based strategy to enable extensive robotic and human surface exploration operations and a related on-going demonstration program for a fuel cell based power plant for rover applications. Technology commonalities between ISRU, life support systems, and Extra Vehicular Activity (EVA), applications will also be presented.

Robots and humans: synergy in planetary exploration

NASA Technical Reports Server (NTRS)

Landis, Geoffrey A.

2004-01-01

How will humans and robots cooperate in future planetary exploration? Are humans and robots fundamentally separate modes of exploration, or can humans and robots work together to synergistically explore the solar system? It is proposed that humans and robots can work together in exploring the planets by use of telerobotic operation to expand the function and usefulness of human explorers, and to extend the range of human exploration to hostile environments. Published by Elsevier Ltd.

Increasing Facilitator Effectiveness by Bridging Two Modes of Consciousness.

ERIC Educational Resources Information Center

Alperson, Erma Dosamantes

To fully explore the range of our human consciousness, we must have access to all available modes of experiencing: the bodily-implicit and the rational-explicit. To the extent that we become alienated from our bodily-felt side, we respond solely in terms of what the external situation demands. We lose sight of our own feelings and needs and…

Stigma, HIV and AIDS: An Exploration and Elaboration of the Illness Trajectory Surrounding HIV Infection and AIDS.

ERIC Educational Resources Information Center

Alonzo, Angelo A.; Reynolds, Nancy R.

In this paper, human immunodeficiency virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS) are analyzed in terms of stigma and illness trajectory. The primary purpose is to conceptualize how individuals with HIV/AIDS experience stigma and to demonstrate how these experiences are affected by the social and biophysical dimensions of the…

Development of A Dance Curriculum for Young Children. CAREL Arts and Humanities Curriculum Development Program for Young Children.

ERIC Educational Resources Information Center

Dimondstein, Geraldine; Prevots, Naima

The long-range objective of the Central Atlantic Regional Educational Laboratory (CAREL) dance program was to develop children's ability to solve problems in movement terms and to express emotional involvement and creative ideas through dance. Workshops were conducted for 15 non-specialist teachers to explore the concepts of space, time, and…

Novel ecosystems: theoretical and management aspects of the new ecological world order

Treesearch

Richard J. Hobbs; Salvatore Arico; James Aronson; Jill S. Baron; Peter Bridgewater; Viki A. Cramer; Paul R. Epstein; John J. Ewel; Carlos A. Klink; Ariel E. Lugo; David Norton; Dennis Ojima; Richardson David M.; Eric W. Sanderson; Fernando Valladares; Montserrat Vilà; Regino Zamora; Martin Zobel

2006-01-01

We explore the issues relevant to those types of ecosystems containing new combinations of species that arise through human action, environmental change, and the impacts of the deliberate and inadvertent introduction of species from other regions. Novel ecosystems (also termed ‘emerging ecosystems’) result when species occur in combinations and relative abundances that...

The Impact of Congruency between Preferred and Actual Learning Environments on Tenth Graders' Science Literacy in Taiwan

ERIC Educational Resources Information Center

Chang, Chun-Yen; Yeh, Ting-Kuang; Lin, Chun-Yen; Chang, Yueh-Hsia; Chen, Chia-Li D.

2010-01-01

This study explored the effects of congruency between preferred and actual learning environment (PLE & ALE) perceptions on students' science literacy in terms of science concepts, attitudes toward science, and the understanding of the nature of science in an innovative curriculum of High Scope Project, namely Sci-Tech Mind and Humane Heart…

Human Capital, Poverty, Educational Access and Exclusion: The Case of Ghana 1991-2006. CREATE Pathways to Access. Research Monograph No. 22

ERIC Educational Resources Information Center

Rolleston, Caine

2009-01-01

The period since 1991 has seen a general improvement both in terms of household welfare and schooling participation in Ghana. This monograph explores the patterns among descriptive indicators and uses regression analysis to examine possible causal relationships with special reference to the role of education in determining welfare and its…

Mirror neurons, birdsong, and human language: a hypothesis.

PubMed

Levy, Florence

2011-01-01

THE MIRROR SYSTEM HYPOTHESIS AND INVESTIGATIONS OF BIRDSONG ARE REVIEWED IN RELATION TO THE SIGNIFICANCE FOR THE DEVELOPMENT OF HUMAN SYMBOLIC AND LANGUAGE CAPACITY, IN TERMS OF THREE FUNDAMENTAL FORMS OF COGNITIVE REFERENCE: iconic, indexical, and symbolic. Mirror systems are initially iconic but can progress to indexical reference when produced without the need for concurrent stimuli. Developmental stages in birdsong are also explored with reference to juvenile subsong vs complex stereotyped adult syllables, as an analogy with human language development. While birdsong remains at an indexical reference stage, human language benefits from the capacity for symbolic reference. During a pre-linguistic "babbling" stage, recognition of native phonemic categories is established, allowing further development of subsequent prefrontal and linguistic circuits for sequential language capacity.

Mirror Neurons, Birdsong, and Human Language: A Hypothesis

PubMed Central

Levy, Florence

2012-01-01

The mirror system hypothesis and investigations of birdsong are reviewed in relation to the significance for the development of human symbolic and language capacity, in terms of three fundamental forms of cognitive reference: iconic, indexical, and symbolic. Mirror systems are initially iconic but can progress to indexical reference when produced without the need for concurrent stimuli. Developmental stages in birdsong are also explored with reference to juvenile subsong vs complex stereotyped adult syllables, as an analogy with human language development. While birdsong remains at an indexical reference stage, human language benefits from the capacity for symbolic reference. During a pre-linguistic “babbling” stage, recognition of native phonemic categories is established, allowing further development of subsequent prefrontal and linguistic circuits for sequential language capacity. PMID:22287950

Exogeoconservation: Protecting geological heritage on celestial bodies

NASA Astrophysics Data System (ADS)

Matthews, Jack J.; McMahon, Sean

2018-08-01

Geoconservation is an increasingly widely adopted theoretical, practical and administrative approach to the protection of geological and geomorphological features of special scientific, functional, historic, cultural, aesthetic, or ecological value. Protected sites on Earth include natural rocky outcrops, shorelines, river banks, and landscapes, as well as human-made structures such as road cuts and quarries exposing geological phenomena. However, geoconservation has rarely been discussed in the context of other rocky and icy planets, rings, moons, dwarf planets, asteroids, or comets, which present extraordinarily diverse, beautiful, and culturally, historically and scientifically important geological phenomena. Here we propose to adapt geoconservation strategies for protecting the geological heritage of these celestial bodies, and introduce the term 'exogeoconservation' and other associated terms for this purpose. We argue that exogeoconservation is acutely necessary for the scientific exploration and responsible stewardship of celestial bodies, and suggest how this might be achieved and managed by means of international protocols. We stress that such protocols must be sensitive to the needs of scientific, industrial, and other human activities, and not unduly prohibitive. However, with space exploration and exploitation likely to accelerate in coming decades, it is increasingly important that an internationally agreed, holistic framework be developed for the protection of our common 'exogeoheritage'.

Brain Activation During Singing: "Clef de Sol Activation" Is the "Concert" of the Human Brain.

PubMed

Mavridis, Ioannis N; Pyrgelis, Efstratios-Stylianos

2016-03-01

Humans are the most complex singers in nature, and the human voice is thought by many to be the most beautiful musical instrument. Aside from spoken language, singing represents a second mode of acoustic communication in humans. The purpose of this review article is to explore the functional anatomy of the "singing" brain. Methodologically, the existing literature regarding activation of the human brain during singing was carefully reviewed, with emphasis on the anatomic localization of such activation. Relevant human studies are mainly neuroimaging studies, namely functional magnetic resonance imaging and positron emission tomography studies. Singing necessitates activation of several cortical, subcortical, cerebellar, and brainstem areas, served and coordinated by multiple neural networks. Functionally vital cortical areas of the frontal, parietal, and temporal lobes bilaterally participate in the brain's activation process during singing, confirming the latter's role in human communication. Perisylvian cortical activity of the right hemisphere seems to be the most crucial component of this activation. This also explains why aphasic patients due to left hemispheric lesions are able to sing but not speak the same words. The term clef de sol activation is proposed for this crucial perisylvian cortical activation due to the clef de sol shape of the topographical distribution of these cortical areas around the sylvian fissure. Further research is needed to explore the connectivity and sequence of how the human brain activates to sing.

A truly international lunar base as the next logical step for human spaceflight

NASA Astrophysics Data System (ADS)

Bonneville, Richard

Recent fora (e.g. the ISECG’s Global Exploration Roadmap) have highlighted a human mission to Mars as the long term goal for space exploration, with intermediate stages such as missions to the Moon and/or to asteroids. But actually a human mission to Mars will not be feasible before several decades, whereas in the meantime robotic missions will be able to provide an enormous amount of information on the history and the environment of the red planet, at a rather moderate cost. And if we consider missions to asteroids, introducing a human in the loop will require a considerably higher complexity and cost than using robots, with no significant additional benefit. The only sensible and feasible objective of a near-term human spaceflight program would be the edification of a lunar base, under the condition that this base is built as a true international venture. Science will not be the main driver; it has to be acknowledged from the beginning that the true main goal will be peace and a nucleus of international cooperation between the big countries. The ISS in the 1990’s had illustrated a calmed relation between the USA, together with Europe, Canada and Japan, and Russia. A lunar base should be the symbol of a similar calmed relation between the same partners and China. For the benefit of all humankind this extra continent, the Moon, will be used only for peaceful purposes, like Antarctica today, and will not become the theatre or the stake of conflicts. The financial cost of that venture will be high, but not that high if it is compared with the cost of recent wars; so let us go to the Moon, OK, but let us get there together.

Some Strategic Considerations Related to the Potential Use of Water Resource Deposits on Mars by Future Human Explorers

NASA Technical Reports Server (NTRS)

Beaty, D.W.; Mueller, R.P.; Bussey, D.B.; Davis, R.M.; Hays, L.E.; Hoffman, S.J.

2016-01-01

A long-term base on Mars, at the center of an "Exploration Zone", would require substantial quantities of in-situ resources. Although water is not the only resource on Mars of potential interest, it stands out as the one that most dominates long-lead strategic planning. It is needed for multiple purposes for various human activities (including our own survival!), and in significant quantities. The absence of viable deposits could make a surface "field station" logistically unsustainable. Therefore, identification of deposits, and development of the technology needed to make use of these deposits, are an important priority in the period leading up to a human mission to Mars. Given our present understanding of Mars, ice and hydrated minerals appear to be the best potential sources for the quantity of water expected to be needed. The methods for their extraction would be different for these two classes of deposits, and at the present time it is unknown which would ultimately be an optimal solution. The deposits themselves would also ultimately have to be judged by certain economics that take into account information about geologic and engineering attributes and the "cost" of obtaining this information. Ultimately much of this information would need to come from precursor missions, which would be essential if utilization of martian is situ water resources is to become a part of human exploration of Mars.

Pb Neurotoxicity: Neuropsychological Effects of Lead Toxicity

PubMed Central

Mason, Lisa H.; Harp, Jordan P.; Han, Dong Y.

2014-01-01

Neurotoxicity is a term used to describe neurophysiological changes caused by exposure to toxic agents. Such exposure can result in neurocognitive symptoms and/or psychiatric disturbances. Common toxic agents include heavy metals, drugs, organophosphates, bacterial, and animal neurotoxins. Among heavy metal exposures, lead exposure is one of the most common exposures that can lead to significant neuropsychological and functional decline in humans. In this review, neurotoxic lead exposure's pathophysiology, etiology, and epidemiology are explored. In addition, commonly associated neuropsychological difficulties in intelligence, memory, executive functioning, attention, processing speed, language, visuospatial skills, motor skills, and affect/mood are explored. PMID:24516855

Challenges of Rover Navigation at the Lunar Poles

NASA Technical Reports Server (NTRS)

Nefian, Ara; Deans, Matt; Bouyssounouse, Xavier; Edwards, Larry; Dille, Michael; Fong, Terry; Colaprete, Tony; Miller, Scott; Vaughan, Ryan; Andrews, Dan;

New methodologies for patients rehabilitation.

PubMed

Fardoun, H M; Mashat, A S; Lange, B

2015-01-01

The present editorial is part of the focus theme of Methods of Information in Medicine titled "New Methodologies for Patients Rehabilitation", with a specific focus on technologies and human factors related to the use of Information and Communication Technologies (ICT) for improving patient rehabilitation. The focus theme explores different dimensions of empowerment methodologies for disabled people in terms of rehabilitation and health care, and to explores the extent to which ICT is a useful tool in this process. The focus theme lists a set of research papers that present different ways of using ICT to develop advanced systems that help disabled people in their rehabilitation process.

Foundational Methane Propulsion Related Technology Efforts, and Challenges for Applications to Human Exploration Beyond Earth Orbit

NASA Technical Reports Server (NTRS)

Brown, Thomas; Klem, Mark; McRight, Patrick

2016-01-01

Current interest in human exploration beyond earth orbit is driving requirements for high performance, long duration space transportation capabilities. Continued advancement in photovoltaic power systems and investments in high performance electric propulsion promise to enable solar electric options for cargo delivery and pre-deployment of operational architecture elements. However, higher thrust options are required for human in-space transportation as well as planetary descent and ascent functions. While high thrust requirements for interplanetary transportation may be provided by chemical or nuclear thermal propulsion systems, planetary descent and ascent systems are limited to chemical solutions due to their higher thrust to weight and potential planetary protection concerns. Liquid hydrogen fueled systems provide high specific impulse, but pose challenges due to low propellant density and the thermal issues of long term propellant storage. Liquid methane fueled propulsion is a promising compromise with lower specific impulse, higher bulk propellant density and compatibility with proposed in-situ propellant production concepts. Additionally, some architecture studies have identified the potential for commonality between interplanetary and descent/ascent propulsion solutions using liquid methane (LCH4) and liquid oxygen (LOX) propellants. These commonalities may lead to reduced overall development costs and more affordable exploration architectures. With this increased interest, it is critical to understand the current state of LOX/LCH4 propulsion technology and the remaining challenges to its application to beyond earth orbit human exploration. This paper provides a survey of NASA's past and current methane propulsion related technology efforts, assesses the accomplishments to date, and examines the remaining risks associated with full scale development.

Habitation Concepts for Human Missions Beyond Low-Earth-Orbit

NASA Technical Reports Server (NTRS)

Smitherman, David V.

2016-01-01

The Advanced Concepts Office at the NASA Marshall Space Flight Center has been engaged for several years in a variety of study activities to help define various options for deep space habitation. This work includes study activities supporting asteroid, lunar and Mars mission activities for the Human spaceflight Architecture Team (HAT), the Deep Space Habitat (DSH) project, and the Exploration Augmentation Module (EAM) project through the NASA Advanced Exploration Systems (AES) Program. The missions under consideration required human habitation beyond low-Earth-orbit (LEO) including deep space habitation in the lunar vicinity to support asteroid retrieval missions, human and robotic lunar surface missions, deep space research facilities, Mars vehicle servicing, and Mars transit missions. Additional considerations included international interest and near term capabilities through the International Space Station (ISS) and Space Launch System (SLS) programs. A variety of habitat layouts have been considered, including those derived from the existing ISS systems, those that could be fabricated from SLS components, and other approaches. This paper presents an overview of several leading designs explored in late fiscal year (FY) 2015 for asteroid, lunar, and Mars mission habitats and identifies some of the known advantages and disadvantages inherent in each. Key findings indicate that module diameters larger than those used for ISS can offer lighter structures per unit volume, and sufficient volume to accommodate consumables for long-duration missions in deep space. The information provided with the findings includes mass and volume data that should be helpful to future exploration mission planning and deep space habitat design efforts.

Prosodic alignment in human-computer interaction

NASA Astrophysics Data System (ADS)

Suzuki, N.; Katagiri, Y.

2007-06-01

Androids that replicate humans in form also need to replicate them in behaviour to achieve a high level of believability or lifelikeness. We explore the minimal social cues that can induce in people the human tendency for social acceptance, or ethopoeia, toward artifacts, including androids. It has been observed that people exhibit a strong tendency to adjust to each other, through a number of speech and language features in human-human conversational interactions, to obtain communication efficiency and emotional engagement. We investigate in this paper the phenomena related to prosodic alignment in human-computer interactions, with particular focus on human-computer alignment of speech characteristics. We found that people exhibit unidirectional and spontaneous short-term alignment of loudness and response latency in their speech in response to computer-generated speech. We believe this phenomenon of prosodic alignment provides one of the key components for building social acceptance of androids.

The Human Figure and Urban Ground: Cyborgs and the City.

PubMed

Parkhurst, Aaron

2016-07-01

Recent years have seen developments in cyborgian movements in which people play and experiment with the boundaries of human flesh and aesthetic realities. Some individuals develop novel intimate relationships with devices that, each in their own way, interfere with human subjectivity. Public dissemination of these movements often proposes notions of transcendence, therapy, post-humanism and trans-humanism, but often fails to outline the lived-experience of those who explore cyborgian identity as an alternative mode of being in the world. This paper briefly follows self-described cyborgs who delimit the body through sensory 'enhancement' in an effort to disrupt common relationships between the human figure and the urban ground. Borrowing from Lewis Mumford's concepts of biotechnics, I propose cyborgian engagement as a type of psychodynamic living. Rather than focus on post-human discourses, these cyborgs turn to the natural world for inspiration in shaping the terms of engagement between their bodies and the city.

Neurobiology of fibromyalgia and chronic widespread pain.

PubMed

Sluka, Kathleen A; Clauw, Daniel J

2016-12-03

Fibromyalgia is the current term for chronic widespread musculoskeletal pain for which no alternative cause can be identified. The underlying mechanisms, in both human and animal studies, for the continued pain in individuals with fibromyalgia will be explored in this review. There is a substantial amount of support for alterations of central nervous system nociceptive processing in people with fibromyalgia, and that psychological factors such as stress can enhance the pain experience. Emerging evidence has begun exploring other potential mechanisms including a peripheral nervous system component to the generation of pain and the role of systemic inflammation. We will explore the data and neurobiology related to the role of the CNS in nociceptive processing, followed by a short review of studies examining potential peripheral nervous system changes and cytokine involvement. We will not only explore the data from human subjects with fibromyalgia but will relate this to findings from animal models of fibromyalgia. We conclude that fibromyalgia and related disorders are heterogenous conditions with a complicated pathobiology with patients falling along a continuum with one end a purely peripherally driven painful condition and the other end of the continuum is when pain is purely centrally driven. Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

Mars Surface Systems Common Capabilities and Challenges for Human Missions

NASA Technical Reports Server (NTRS)

Toups, Larry; Hoffman, Stephen J.; Watts, Kevin

2016-01-01

This paper describes the current status of common systems and operations as they are applied to actual locations on Mars that are representative of Exploration Zones (EZ) - NASA's term for candidate locations where humans could land, live and work on the martian surface. Given NASA's current concepts for human missions to Mars, an EZ is a collection of Regions of Interest (ROIs) located within approximately 100 kilometers of a centralized landing site. ROIs are areas that are relevant for scientific investigation and/or development/maturation of capabilities and resources necessary for a sustainable human presence. An EZ also contains a habitation site that will be used by multiple human crews during missions to explore and utilize the ROIs within the EZ. The Evolvable Mars Campaign (EMC), a description of NASA's current approach to these human Mars missions, assumes that a single EZ will be identified within which NASA will establish a substantial and durable surface infrastructure that will be used by multiple human crews. The process of identifying and eventually selecting this single EZ will likely take many years to finalized. Because of this extended EZ selection process it becomes important to evaluate the current suite of surface systems and operations being evaluated for the EMC as they are likely to perform at a variety of proposed EZ locations and for the types of operations - both scientific and development - that are proposed for these candidate EZs. It is also important to evaluate proposed EZs for their suitability to be explored or developed given the range of capabilities and constraints for the types of surface systems and operations being considered within the EMC.

Space Resources Roundtable 2

NASA Technical Reports Server (NTRS)

Ignatiev, A.

2000-01-01

Contents include following: Developing Technologies for Space Resource Utilization - Concept for a Planetary Engineering Research Institute. Results of a Conceptual Systems Analysis of Systems for 200 m Deep Sampling of the Martian Subsurface. The Role of Near-Earth Asteroids in Long-Term Platinum Supply. Core Drilling for Extra-Terrestrial Mining. Recommendations by the "LSP and Manufacturing" Group to the NSF-NASA Workshop on Autonomous Construction and Manufacturing for Space Electrical Power Systems. Plasma Processing of Lunar and Planetary Materials. Percussive Force Magnitude in Permafrost. Summary of the Issues Regarding the Martian Subsurface Explorer. A Costing Strategy for Manufacturing in Orbit Using Extraterrestrial Resources. Mine Planning for Asteroid Orebodies. Organic-based Dissolution of Silicates: A New Approach to Element Extraction from LunarRegohth. Historic Frontier Processes Active in Future Space-based Mineral Extraction. The Near-Earth Space Surveillance (NIESS) Mission: Discovery, Tracking, and Characterization of Asteroids, Comets, and Artificial Satellites with a microsatellite. Privatized Space Resource Property Ownership. The Fabrication of Silicon Solar Cells on the Moon Using In-Situ Resources. A New Strategy for Exploration Technology Development: The Human Exploration and Development of Space (HEDS) Exploratiori/Commercialization Technology Initiative. Space Resources for Space Tourism. Recovery of Volatiles from the Moon and Associated Issues. Preliminary Analysis of a Small Robot for Martian Regolith Excavation. The Registration of Space-based Property. Continuous Processing with Mars Gases. Drilling and Logging in Space; An Oil-Well Perspective. LORPEX for Power Surges: Drilling, Rock Crushing. An End-To-End Near-Earth Asteroid Resource Exploitation Plan. An Engineering and Cost Model for Human Space Settlement Architectures: Focus on Space Hotels and Moon/Mars Exploration. The Development and Realization of a Silicon-60-based Economy in CisLunar Space. Our Lunar Destiny: Creating a Lunar Economy. Cost-Effective Approaches to Lunar Passenger Transportation. Lunar Mineral Resources: Extraction and Application. Space Resources Development - The Link Between Human Exploration and the Long-term Commercialization of Space. Toward a More Comprehensive Evaluation of Space Information. Development of Metal Casting Molds by Sol-Gel Technology Using Planetary Resources. A New Concept in Planetary Exploration: ISRU with Power Bursts. Bold Space Ventures Require Fervent Public Support. Hot-pressed Iron from Lunar Soil. The Lunar Dust Problem: A Possible Remedy. Considerations on Use of Lunar Regolith in Lunar Constructions. Experimental Study on Water Production by Hydrogen Reduction of Lunar Soil Simulant in a Fixed Bed Reactor.

Human Error: A Concept Analysis

NASA Technical Reports Server (NTRS)

Hansen, Frederick D.

2007-01-01

Human error is the subject of research in almost every industry and profession of our times. This term is part of our daily language and intuitively understood by most people however, it would be premature to assume that everyone's understanding of human error s the same. For example, human error is used to describe the outcome or consequence of human action, the causal factor of an accident, deliberate violations,a nd the actual action taken by a human being. As a result, researchers rarely agree on the either a specific definition or how to prevent human error. The purpose of this article is to explore the specific concept of human error using Concept Analysis as described by Walker and Avant (1995). The concept of human error is examined as currently used in the literature of a variety of industries and professions. Defining attributes and examples of model, borderline, and contrary cases are described. The antecedents and consequences of human error are also discussed and a definition of human error is offered.

Natural capital and ecosystem services informing decisions: From promise to practice

PubMed Central

Guerry, Anne D.; Polasky, Stephen; Lubchenco, Jane; Chaplin-Kramer, Rebecca; Daily, Gretchen C.; Griffin, Robert; Ruckelshaus, Mary; Bateman, Ian J.; Duraiappah, Anantha; Elmqvist, Thomas; Feldman, Marcus W.; Folke, Carl; Hoekstra, Jon; Kareiva, Peter M.; Keeler, Bonnie L.; Li, Shuzhuo; McKenzie, Emily; Ouyang, Zhiyun; Reyers, Belinda; Ricketts, Taylor H.; Rockström, Johan; Tallis, Heather; Vira, Bhaskar

2015-01-01

The central challenge of the 21st century is to develop economic, social, and governance systems capable of ending poverty and achieving sustainable levels of population and consumption while securing the life-support systems underpinning current and future human well-being. Essential to meeting this challenge is the incorporation of natural capital and the ecosystem services it provides into decision-making. We explore progress and crucial gaps at this frontier, reflecting upon the 10 y since the Millennium Ecosystem Assessment. We focus on three key dimensions of progress and ongoing challenges: raising awareness of the interdependence of ecosystems and human well-being, advancing the fundamental interdisciplinary science of ecosystem services, and implementing this science in decisions to restore natural capital and use it sustainably. Awareness of human dependence on nature is at an all-time high, the science of ecosystem services is rapidly advancing, and talk of natural capital is now common from governments to corporate boardrooms. However, successful implementation is still in early stages. We explore why ecosystem service information has yet to fundamentally change decision-making and suggest a path forward that emphasizes: (i) developing solid evidence linking decisions to impacts on natural capital and ecosystem services, and then to human well-being; (ii) working closely with leaders in government, business, and civil society to develop the knowledge, tools, and practices necessary to integrate natural capital and ecosystem services into everyday decision-making; and (iii) reforming institutions to change policy and practices to better align private short-term goals with societal long-term goals. PMID:26082539

Natural capital and ecosystem services informing decisions: From promise to practice.

PubMed

Guerry, Anne D; Polasky, Stephen; Lubchenco, Jane; Chaplin-Kramer, Rebecca; Daily, Gretchen C; Griffin, Robert; Ruckelshaus, Mary; Bateman, Ian J; Duraiappah, Anantha; Elmqvist, Thomas; Feldman, Marcus W; Folke, Carl; Hoekstra, Jon; Kareiva, Peter M; Keeler, Bonnie L; Li, Shuzhuo; McKenzie, Emily; Ouyang, Zhiyun; Reyers, Belinda; Ricketts, Taylor H; Rockström, Johan; Tallis, Heather; Vira, Bhaskar

2015-06-16

The central challenge of the 21st century is to develop economic, social, and governance systems capable of ending poverty and achieving sustainable levels of population and consumption while securing the life-support systems underpinning current and future human well-being. Essential to meeting this challenge is the incorporation of natural capital and the ecosystem services it provides into decision-making. We explore progress and crucial gaps at this frontier, reflecting upon the 10 y since the Millennium Ecosystem Assessment. We focus on three key dimensions of progress and ongoing challenges: raising awareness of the interdependence of ecosystems and human well-being, advancing the fundamental interdisciplinary science of ecosystem services, and implementing this science in decisions to restore natural capital and use it sustainably. Awareness of human dependence on nature is at an all-time high, the science of ecosystem services is rapidly advancing, and talk of natural capital is now common from governments to corporate boardrooms. However, successful implementation is still in early stages. We explore why ecosystem service information has yet to fundamentally change decision-making and suggest a path forward that emphasizes: (i) developing solid evidence linking decisions to impacts on natural capital and ecosystem services, and then to human well-being; (ii) working closely with leaders in government, business, and civil society to develop the knowledge, tools, and practices necessary to integrate natural capital and ecosystem services into everyday decision-making; and (iii) reforming institutions to change policy and practices to better align private short-term goals with societal long-term goals.

Acute and chronic effects of noradrenergic enhancement on transcranial direct current stimulation-induced neuroplasticity in humans.

PubMed

Kuo, Hsiao-I; Paulus, Walter; Batsikadze, Giorgi; Jamil, Asif; Kuo, Min-Fang; Nitsche, Michael A

2017-02-15

Chronic administration of the selective noradrenaline reuptake inhibitor (NRI) reboxetine (RBX) increased and prolonged the long-term potentiation-like plasticity induced by anodal transcranial direct current stimulation (tDCS) for over 24 h. Chronic administration of RBX converted cathodal tDCS-induced long-term depression-like plasticity into facilitation for 120 min. Chronic noradrenergic activity enhancement on plasticity of the human brain might partially explain the delayed therapeutic impact of selective NRIs in depression and other neuropsychiatric diseases. Noradrenaline affects cognition and motor learning processes via its impact on long-term potentiation (LTP) and depression (LTD). We aimed to explore the impact of single dose and chronic administration of the selective noradrenaline reuptake inhibitor (NRI) reboxetine (RBX) on plasticity induced by transcranial direct current stimulation (tDCS) in healthy humans via a double-blinded, placebo-controlled, randomized crossover study. Sixteen healthy volunteers received placebo or single dose RBX (8 mg) before anodal or cathodal tDCS of the primary motor cortex. Afterwards, the same subjects took RBX (8 mg day -1 ) consecutively for 21 days. During this period, two additional interventions were performed (RBX with anodal or cathodal tDCS), to explore the impact of chronic RBX treatment on plasticity. Plasticity was monitored by motor-evoked potential amplitudes elicited by transcranial magnetic stimulation. Chronic administration of RBX increased and prolonged the LTP-like plasticity induced by anodal tDCS for over 24 h. Chronic RBX significantly converted cathodal tDCS-induced LTD-like plasticity into facilitation, as compared to the single dose condition, for 120 min after stimulation. The results show a prominent impact of chronic noradrenergic enhancement on plasticity of the human brain that might partially explain the delayed therapeutic impact of selective NRIs in depression and other neuropsychiatric diseases. © 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society.

Physical/chemical closed-loop water-recycling for long-duration missions

NASA Technical Reports Server (NTRS)

Herrmann, Cal C.; Wydeven, Ted

1990-01-01

Water needs, water sources, and means for recycling water are examined in terms appropriate to the water quality requirements of a small crew and spacecraft intended for long duration exploration missions. Inorganic, organic, and biological hazards are estimated for waste water sources. Sensitivities to these hazards for human uses are estimated. The water recycling processes considered are humidity condensation, carbon dioxide reduction, waste oxidation, distillation, reverse osmosis, pervaporation, electrodialysis, ion exchange, carbon sorption, and electrochemical oxidation. Limitations and applications of these processes are evaluated in terms of water quality objectives. Computerized simulation of some of these chemical processes is examined. Recommendations are made for development of new water recycling technology and improvement of existing technology for near term application to life support systems for humans in space. The technological developments are equally applicable to water needs on earth, in regions where extensive water ecycling is needed or where advanced water treatment is essential to meet EPA health standards.

From a lunar outpost to Mars - Science, policy and the U.S. Space Exploration Initiative

NASA Technical Reports Server (NTRS)

Pilcher, Carl B.

1992-01-01

The technological developments required for the Space Exploration Initiative (SEI) objectives are discussed in terms of scientific investigation and present U.S. space policy. The results of the 90-Day Study are listed which include explicit suggestions for the successful exploration of the moon and Mars. The Outreach/Synthesis program is described which provides four methods for eliciting ideas, technologies, and research venues for lunar and Martian missions. The results of the studies include 5 scientific objectives such as the relationship between the sun, planetary atmospheres, and climate. The protection of human life from potential extraterrestrial hazards such as radiation is also found to be a key objective of SEI as are the theoretical and practical issues of scientific research.

The development of a virtual camera system for astronaut-rover planetary exploration.

PubMed

Platt, Donald W; Boy, Guy A

2012-01-01

A virtual assistant is being developed for use by astronauts as they use rovers to explore the surface of other planets. This interactive database, called the Virtual Camera (VC), is an interactive database that allows the user to have better situational awareness for exploration. It can be used for training, data analysis and augmentation of actual surface exploration. This paper describes the development efforts and Human-Computer Interaction considerations for implementing a first-generation VC on a tablet mobile computer device. Scenarios for use will be presented. Evaluation and success criteria such as efficiency in terms of processing time and precision situational awareness, learnability, usability, and robustness will also be presented. Initial testing and the impact of HCI design considerations of manipulation and improvement in situational awareness using a prototype VC will be discussed.

BDNF and the maturation of posttranscriptional regulatory networks in human SH-SY5Y neuroblast differentiation.

PubMed

Goldie, Belinda J; Barnett, Michelle M; Cairns, Murray J

2014-01-01

The SH-SY5Y culture system is a convenient neuronal model with the potential to elaborate human/primate-specific transcription networks and pathways related to human cognitive disorders. While this system allows for the exploration of specialized features in the human genome, there is still significant debate about how this model should be implemented, and its appropriateness for answering complex functional questions related to human neural architecture. In view of these questions we sought to characterize the posttranscriptional regulatory structure of the two-stage ATRA differentiation, BDNF maturation protocol proposed by Encinas et al. (2000) using integrative whole-genome gene and microRNA (miRNA) expression analysis. We report that ATRA-BDNF induced significant increases in expression of key synaptic genes, brain-specific miRNA and miRNA biogenesis machinery, and in AChE activity, compared with ATRA alone. Functional annotation clustering associated BDNF more significantly with neuronal terms, and with synaptic terms not found in ATRA-only clusters. While our results support use of SH-SY5Y as a neuronal model, we advocate considered selection of the differentiation agent/s relative to the system being modeled.

Life around the North Water ecosystem: Natural and social drivers of change over a millennium.

PubMed

Hastrup, Kirsten; Andersen, Astrid Oberborbeck; Grønnow, Bjarne; Heide-Jørgensen, Mads Peter

2018-04-01

The formation of the North Water in Smith Sound about 4500 years ago, as evidenced by the establishment of bird colonies and human presence, also initiated a long-term anthropogenic agent as part of this High Arctic ecosystem. Different epochs have influenced the human occupation in the area: immigration pulses from Canada and Alaska, trade with meteorite iron throughout the Arctic, introduction of new technologies by whalers and explorers, exploitation of resources by foreigners, political sequestration, export of fox and seal skins and later narwhal products, and recently fishing. Physical drivers in terms of weather and climate affecting the northern hemisphere also impact accessibility and productivity of the ecosystem, with cascading effects on social drivers, again acting back on the natural ecologies. Despite its apparent isolation, the ecosystem had and still has wide ranging spatial ramifications that extend beyond the High Arctic, and include human activity. The challenge is to determine what is internal and what is external to an ecosystem.

Smart Structures for Vibration Control on Long-Term Space Exploration and Habitation Missions

NASA Technical Reports Server (NTRS)

Gattis, Christy B.; Shepard, W. Steve, Jr.

2004-01-01

The current vision for space exploration focuses on human missions to the Moon, Mars, and beyond. To support these goals, it is certain that new vehicles and intermediate bases will be developed, whether that means simply re-direction of the ISS as a "mission research facility" or construction of a lunar base. Since these facilities are expected to be constructed from inherently light-weight materials, this work examines some of the potential sources of vibration and noise as well as means for controlling these vibrations. Many of the operating components within these facilities, such as pumps, fans, and motors, will produce vibrations during operation. These vibrations become structure in which they are housed. Resonances can impact acoustic noise levels and noise quality within the environment, possibly affecting crew health and productivity. For long-term missions in particular, it is expected that crew members will spend significant portions of their time restrained in the structure, such as in seats. As a result, the general health and well-being of the crew can be improved by limiting the harmful effects of human exposure to long-term audible and tactile vibration input. Besides the human factor, this work also examines some operational considerations in which vibrations play an important role. Vibrations can impact the environment for science and in-situ manufacturing research within these vehicles. Since a benign vibratory environment is beneficial for most types of science experiments, there is a need for various forms of vibration control. Because the operational characteristics of a vehicle can change during a long-term mission, it is further expected that the characteristics of many of the vibratory excitations will change with time. Consequently, the form of vibration control needed to improve overall habitability and usefulness of the vehicle or element for exploration missions will rely to some degree on the vibration control system's ability to adapt. To address these needs, this work also examines the development and use of smart materials to tune the dynamic characteristics of the structure in a passive sense. One prime example is the use of an adaptive electrical shunt connected to a piezoelectric patch in order to provide tuned passive vibration damping. The work also examines the use of active vibration control, such as by applying power to that same piezoelectric patch. The overall goal is to examine the use of smart structures that can react to the environment thereby improving the overall living, working, and learning environment for these long-term missions.

Steady-state evoked potentials possibilities for mental-state estimation

NASA Technical Reports Server (NTRS)

Junker, Andrew M.; Schnurer, John H.; Ingle, David F.; Downey, Craig W.

1988-01-01

The use of the human steady-state evoked potential (SSEP) as a possible measure of mental-state estimation is explored. A method for evoking a visual response to a sum-of-ten sine waves is presented. This approach provides simultaneous multiple frequency measurements of the human EEG to the evoking stimulus in terms of describing functions (gain and phase) and remnant spectra. Ways in which these quantities vary with the addition of performance tasks (manual tracking, grammatical reasoning, and decision making) are presented. Models of the describing function measures can be formulated using systems engineering technology. Relationships between model parameters and performance scores during manual tracking are discussed. Problems of unresponsiveness and lack of repeatability of subject responses are addressed in terms of a need for loop closure of the SSEP. A technique to achieve loop closure using a lock-in amplifier approach is presented. Results of a study designed to test the effectiveness of using feedback to consciously connect humans to their evoked response are presented. Findings indicate that conscious control of EEG is possible. Implications of these results in terms of secondary tasks for mental-state estimation and brain actuated control are addressed.

Exploration Science Opportunities for Students within Higher Education

NASA Astrophysics Data System (ADS)

Bailey, Brad; Minafra, Joseph; Schmidt, Gregory

2016-10-01

The NASA Solar System Exploration Research Virtual Institute (SSERVI) is a virtual institute focused on exploration science related to near-term human exploration targets, training the next generation of lunar scientists, and education and public outreach. As part of the SSERVI mission, we act as a hub for opportunities that engage the public through education and outreach efforts in addition to forming new interdisciplinary, scientific collaborations.SSERVI provides opportunities for students to bridge the scientific and generational gap currently existing in the planetary exploration field. This bridge is essential to the continued international success of scientific, as well as human and robotic, exploration.The decline in funding opportunities after the termination of the Apollo missions to the Moon in the early 1970's produced a large gap in both the scientific knowledge and experience of the original lunar Apollo researchers and the resurgent group of young lunar/NEA researchers that have emerged within the last 15 years. One of SSERVI's many goals is to bridge this gap through the many networking and scientific connections made between young researchers and established planetary principle investigators. To this end, SSERVI has supported the establishment of NextGen Lunar Scientists and Engineers group (NGLSE), a group of students and early-career professionals designed to build experience and provide networking opportunities to its members. SSERVI has also created the LunarGradCon, a scientific conference dedicated solely to graduate and undergraduate students working in the lunar field. Additionally, SSERVI produces monthly seminars and bi-yearly virtual workshops that introduce students to the wide variety of exploration science being performed in today's research labs. SSERVI also brokers opportunities for domestic and international student exchange between collaborating laboratories as well as internships at our member institutions. SSERVI provides a bridge that is essential to the continued international success of scientific, as well as human and robotic, exploration.

Space Studies of the Earth-Moon System, Planets, and Small Bodies of the Solar System (B) Past, Present and Future of Small Body Science and Exploration (B0.4)

NASA Technical Reports Server (NTRS)

Abell, Paul; Mazanek, Dan; Reeves, Dan; Chodas, Paul; Gates, Michele; Johnson, Lindley; Ticker, Ronald

2016-01-01

To achieve its long-term goal of sending humans to Mars, the National Aeronautics and Space Administration (NASA) plans to proceed in a series of incrementally more complex human space flight missions. Today, human flight experience extends only to Low- Earth Orbit (LEO), and should problems arise during a mission, the crew can return to Earth in a matter of minutes to hours. The next logical step for human space flight is to gain flight experience in the vicinity of the Moon. These cis-lunar missions provide a "proving ground" for the testing of systems and operations while still accommodating an emergency return path to the Earth that would last only several days. Cis-lunar mission experience will be essential for more ambitious human missions beyond the Earth-Moon system, which will require weeks, months, or even years of transit time. In addition, NASA has been given a Grand Challenge to find all asteroid threats to human populations and know what to do about them. Obtaining knowledge of asteroid physical properties combined with performing technology demonstrations for planetary defense provide much needed information to address the issue of future asteroid impacts on Earth. Hence the combined objectives of human exploration and planetary defense give a rationale for the Asteroid Re-direct Mission (ARM).

Human health and performance considerations for near earth asteroids (NEA)

NASA Astrophysics Data System (ADS)

Steinberg, Susan; Kundrot, Craig; Charles, John

2013-11-01

Humans are considered as a system in the design of any deep space exploration mission. The addition of many potential near asteroid (NEA) destinations to the existing multiple mission architecture for Lunar and Mars missions increases the complexity of human health and performance issues that are anticipated for exploration of space. We suggest that risks to human health and performance be analyzed in terms of the 4 major parameters related to multiple mission architecture: destination, duration, distance and vehicle design. Geological properties of the NEA will influence design of exploration tasks related to sample handling and containment, and extravehicular activity (EVA) capabilities including suit ports and tools. A robotic precursor mission that collects basic information on NEA surface properties would reduce uncertainty about these aspects of the mission as well as aid in mission architecture and exploration task design. Key mission parameters are strongly impacted by duration and distance. The most critical of these is deep-space radiation exposure without even the temporary shielding of a nearby large planetary body. The current space radiation permissible exposure limits (PEL) limits mission duration to 3-10 months depending on age, gender and stage of the solar cycle. Duration also impacts mission architectures including countermeasures for bone, muscle, and cardiovascular atrophy during continuous weightlessness; and behavioral and psychological issues resulting from isolation and confinement. Distance affects communications and limits abort and return options for a NEA mission. These factors are anticipated to have important effects on crew function and autonomous operations, as well as influence medical capability, supplies and training requirements of the crew. The design of a habitat volume that can maintain the physical and psychological health of the crew and support mission operations with limited intervention from earth will require an integrated research and development effort between NASA's Human Research Program (HRP), engineering and human factors groups. Packaging food to extend shelf life and waste management will be important components of vehicle subsystem design.

Arousal regulation and affective adaptation to human responsiveness by a robot that explores and learns a novel environment

PubMed Central

Hiolle, Antoine; Lewis, Matthew; Cañamero, Lola

2014-01-01

In the context of our work in developmental robotics regarding robot–human caregiver interactions, in this paper we investigate how a “baby” robot that explores and learns novel environments can adapt its affective regulatory behavior of soliciting help from a “caregiver” to the preferences shown by the caregiver in terms of varying responsiveness. We build on two strands of previous work that assessed independently (a) the differences between two “idealized” robot profiles—a “needy” and an “independent” robot—in terms of their use of a caregiver as a means to regulate the “stress” (arousal) produced by the exploration and learning of a novel environment, and (b) the effects on the robot behaviors of two caregiving profiles varying in their responsiveness—“responsive” and “non-responsive”—to the regulatory requests of the robot. Going beyond previous work, in this paper we (a) assess the effects that the varying regulatory behavior of the two robot profiles has on the exploratory and learning patterns of the robots; (b) bring together the two strands previously investigated in isolation and take a step further by endowing the robot with the capability to adapt its regulatory behavior along the “needy” and “independent” axis as a function of the varying responsiveness of the caregiver; and (c) analyze the effects that the varying regulatory behavior has on the exploratory and learning patterns of the adaptive robot. PMID:24860492

A pilot study of the feasibility of long-term human bone balance during perimenopause using a 41Ca tracer

NASA Astrophysics Data System (ADS)

Hui, S. K.; Prior, J.; Gelbart, Z.; Johnson, R. R.; Lentle, B. C.; Paul, M.

2007-06-01

The mechanisms governing calcium fluxes during bone remodeling processes in perimenopausal women are poorly known. Despite higher, albeit erratic, estradiol levels in perimenopause, spine bone loss is greater than during the first five years past the final menstrual flow when estradiol becomes low. Understanding changes during this dynamic transition are important to prevent fragility fractures in midlife and older women. The exploration of long-lived 41Ca (T1/2 = 1.04 × 105 yrs) tracer measurements using accelerator mass spectrometry (AMS) leads to the possibility of monitoring bone remodeling balance. With this new technology, we explored a pilot long-term feasibility study of bone health by measuring the 41Ca trace element in urine for six years from premenopausal to later perimenopausal phases in one midlife woman. We measured bone mineral density in parallel.

Regulatory Anatomy: How "Safety Logics" Structure European Transplant Medicine.

PubMed

Hoeyer, Klaus

2015-07-01

This article proposes the term "safety logics" to understand attempts within the European Union (EU) to harmonize member state legislation to ensure a safe and stable supply of human biological material for transplants and transfusions. With safety logics, I refer to assemblages of discourses, legal documents, technological devices, organizational structures, and work practices aimed at minimizing risk. I use this term to reorient the analytical attention with respect to safety regulation. Instead of evaluating whether safety is achieved, the point is to explore the types of "safety" produced through these logics as well as to consider the sometimes unintended consequences of such safety work. In fact, the EU rules have been giving rise to complaints from practitioners finding the directives problematic and inadequate. In this article, I explore the problems practitioners face and why they arise. In short, I expose the regulatory anatomy of the policy landscape.

The Exploration of a Selection of Conative Constructs Relevant to Learning and Performance. Project 2.3. Complex Performance Assessments: Expanding the Scope and Approaches to Assessment. Defining Conative Construct.

ERIC Educational Resources Information Center

Jackson, Douglas N.

The term "conative" is used to describe constructs that span both motivational and volitional aspects of human behavior, distinguished from constructs that emphasize cognition and affection. Among the conative constructs are achievement strivings, beliefs about self-esteem and self-efficacy, interests and attitudes about learning,…

Human Rights Discourse in the Sustainable Development Agenda Avoids Obligations and Entitlements Comment on "Rights Language in the Sustainable Development Agenda: Has Right to Health Discourse and Norms Shaped Health Goals?".

PubMed

Williams, Carmel; Blaiklock, Alison

2016-03-05

Our commentary on Forman et al paper explores their thesis that right to health language can frame global health policy responses. We examined human rights discourse in the outcome documents from three 2015 United Nations (UN) summits and found rights-related terms are used in all three. However, a deeper examination of the discourse finds the documents do not convey the obligations and entitlements of human rights and international human rights law. The documents contain little that can be used to empower the participation of those already left behind and to hold States and the private sector to account for their human rights duties. This is especially worrying in a neoliberal era. © 2016 by Kerman University of Medical Sciences.

Mixed-Initiative Activity Planning for Mars Rovers

NASA Technical Reports Server (NTRS)

Bresina, John; Jonsson, Ari; Morris, Paul; Rajan, Kanna

2005-01-01

One of the ground tools used to operate the Mars Exploration Rovers is a mixed-initiative planning system called MAPGEN. The role of the system is to assist operators building daily plans for each of the rovers, maximizing science return, while maintaining rover safety and abiding by science and engineering constraints. In this paper, we describe the MAPGEN system, focusing on the mixed-initiative planning aspect. We note important challenges, both in terms of human interaction and in terms of automated reasoning requirements. We then describe the approaches taken in MAPGEN, focusing on the novel methods developed by our team.

The Moon as a way station for planetary exploration

NASA Technical Reports Server (NTRS)

Duke, M. B.

1994-01-01

The Moon can be on the pathway to the exploration of other planets in the solar system in three distinct ways: science, systems and technology experience, and as a fuel depot. The most important of these from the point of view of near term potential is to provide systems and technology development that increases capability and reduces the cost and risk of Mars exploration. The development of capability for a lunar program, if planned properly, can significantly influence strategies for sending humans to Mars. In conclusion, the exploration of the Moon should come before the exploration of Mars. This is a statement of developmental and operational logic that is almost self evident. Technological advancement could, however, make a different strategy reasonable. Principally, the development of a propulsion capability that could substantially reduce round trip mission times to Mars (to say 6 to 12 months) could eliminate much of the argument that the Moon is an essential stepping stone. This would reduce the problem to one of similitude with current space station program concepts. However, for any reasonably near term program, such technology does not appear likely to be available. Thus, the answer remains that lunar exploration should come first, and the expectation that it will make Mars exploration much more affordable and safe. The use of lunar propellant in an Earth-Mars transportation system is not practical with current propulsion systems; however, the discovery of caches of water ice at a lunar pole could change considerably the strategy for utilization of lunar resources in planetary exploration.

Separation of Carbon Monoxide and Carbon Dioxide for Mars ISRU

NASA Technical Reports Server (NTRS)

Walton, Krista S.; LeVan, M. Douglas

2004-01-01

The atmosphere of Mars has many resources that can be processed to produce things such as oxygen, fuel, buffer gas, and water for support of human exploration missions. Successful manipulation of these resources is crucial for safe, cost-effective, and self-sufficient long-term human exploration of Mars. In our research, we are developing enabling technologies that require fundamental knowledge of adsorptive gas storage and separation processes. In particular, we are designing and constructing an innovative, low mass, low power separation device to recover carbon dioxide and carbon monoxide for Mars ISRU (in-situ resource utilization). The technology has broad implications for gas storage and separations for gas-solid systems that are ideally suited for reduced gravitational environments. This paper describes our separation process design and experimental procedures and reports results for the separation of CO2 and CO by a four-step adsorption cycle.

Supersonic Retropropulsion Technology Development in NASA's Entry, Descent, and Landing Project

NASA Technical Reports Server (NTRS)

Edquist, Karl T.; Berry, Scott A.; Rhode, Matthew N.; Kelb, Bil; Korzun, Ashley; Dyakonov, Artem A.; Zarchi, Kerry A.; Schauerhamer, Daniel G.; Post, Ethan A.

2012-01-01

NASA's Entry, Descent, and Landing (EDL) space technology roadmap calls for new technologies to achieve human exploration of Mars in the coming decades [1]. One of those technologies, termed Supersonic Retropropulsion (SRP), involves initiation of propulsive deceleration at supersonic Mach numbers. The potential benefits afforded by SRP to improve payload mass and landing precision make the technology attractive for future EDL missions. NASA's EDL project spent two years advancing the technological maturity of SRP for Mars exploration [2-15]. This paper summarizes the technical accomplishments from the project and highlights challenges and recommendations for future SRP technology development programs. These challenges include: developing sufficiently large SRP engines for use on human-scale entry systems; testing and computationally modelling complex and unsteady SRP fluid dynamics; understanding the effects of SRP on entry vehicle stability and controllability; and demonstrating sub-scale SRP entry systems in Earth's atmosphere.

Human Exploration and Avionic Technology Challenges

NASA Technical Reports Server (NTRS)

Benjamin, Andrew L.

2005-01-01

For this workshop, I will identify critical avionic gaps, enabling technologies, high-pay off investment opportunities, promising capabilities, and space applications for human lunar and Mars exploration. Key technology disciplines encompass fault tolerance, miniaturized instrumentation sensors, MEMS-based guidance, navigation, and controls, surface communication networks, and rendezvous and docking. Furthermore, I will share bottom-up strategic planning relevant to manned mission -driven needs. Blending research expertise, facilities, and personnel with internal NASA is vital to stimulating collaborative technology solutions that achieve NASA grand vision. Retaining JSC expertise in unique and critical areas is paramount to our long-term success. Civil servants will maintain key roles in setting technology agenda, ensuring quality results, and integrating technologies into avionic systems and manned missions. Finally, I will present to NASA, academia, and the aerospace community some on -going and future advanced avionic technology programs and activities that are relevant to our mission goals and objectives.

Utilizing Radioisotope Power Systems for Human Lunar Exploration

NASA Technical Reports Server (NTRS)

Schreiner, Timothy M.

2005-01-01

The Vision for Space Exploration has a goal of sending crewed missions to the lunar surface as early as 2015 and no later than 2020. The use of nuclear power sources could aid in assisting crews in exploring the surface and performing In-Situ Resource Utilization (ISRU) activities. Radioisotope Power Systems (RPS) provide constant sources of electrical power and thermal energy for space applications. RPSs were carried on six of the crewed Apollo missions to power surface science packages, five of which still remain on the lunar surface. Future RPS designs may be able to play a more active role in supporting a long-term human presence. Due to its lower thermal and radiation output, the planned Stirling Radioisotope Generator (SRG) appears particularly attractive for manned applications. The MCNPX particle transport code has been used to model the current SRG design to assess its use in proximity with astronauts operating on the surface. Concepts of mobility and ISRU infrastructure were modeled using MCNPX to analyze the impact of RPSs on crewed mobility systems. Strategies for lowering the radiation dose were studied to determine methods of shielding the crew from the RPSs.

Heliospheric Physics and NASA's Vision for Space Exploration

NASA Technical Reports Server (NTRS)

Minow, Joseph I.

2007-01-01

The Vision for Space Exploration outlines NASA's development of a new generation of human-rated launch vehicles to replace the Space Shuttle and an architecture for exploring the Moon and Mars. The system--developed by the Constellation Program--includes a near term (approx. 2014) capability to provide crew and cargo service to the International Space Station after the Shuttle is retired in 2010 and a human return to the Moon no later than 2020. Constellation vehicles and systems will necessarily be required to operate efficiently, safely, and reliably in the space plasma and radiation environments of low Earth orbit, the Earth's magnetosphere, interplanetary space, and on the lunar surface. This presentation will provide an overview of the characteristics of space radiation and plasma environments relevant to lunar programs including the trans-lunar injection and trans-Earth injection trajectories through the Earth's radiation belts, solar wind surface dose and plasma wake charging environments in near lunar space, energetic solar particle events, and galactic cosmic rays and discusses the design and operational environments being developed for lunar program requirements to assure that systems operate successfully in the space environment.

Labels, cognomes, and cyclic computation: an ethological perspective.

PubMed

Murphy, Elliot

2015-01-01

For the past two decades, it has widely been assumed by linguists that there is a single computational operation, Merge, which is unique to language, distinguishing it from other cognitive domains. The intention of this paper is to progress the discussion of language evolution in two ways: (i) survey what the ethological record reveals about the uniqueness of the human computational system, and (ii) explore how syntactic theories account for what ethology may determine to be human-specific. It is shown that the operation Label, not Merge, constitutes the evolutionary novelty which distinguishes human language from non-human computational systems; a proposal lending weight to a Weak Continuity Hypothesis and leading to the formation of what is termed Computational Ethology. Some directions for future ethological research are suggested.

Labels, cognomes, and cyclic computation: an ethological perspective

PubMed Central

Murphy, Elliot

2015-01-01

For the past two decades, it has widely been assumed by linguists that there is a single computational operation, Merge, which is unique to language, distinguishing it from other cognitive domains. The intention of this paper is to progress the discussion of language evolution in two ways: (i) survey what the ethological record reveals about the uniqueness of the human computational system, and (ii) explore how syntactic theories account for what ethology may determine to be human-specific. It is shown that the operation Label, not Merge, constitutes the evolutionary novelty which distinguishes human language from non-human computational systems; a proposal lending weight to a Weak Continuity Hypothesis and leading to the formation of what is termed Computational Ethology. Some directions for future ethological research are suggested. PMID:26089809

NASA Human Spaceflight Scenarios - Do All Our Models Still Say No?

NASA Technical Reports Server (NTRS)

Zapata, Edgar

2017-01-01

Historically, NASA human spaceflight planning has included healthy doses of life cycle cost analysis. Planners put projects and their cost estimates in a budget context. Estimated costs became expected budgets. Regardless, real budgets rarely matched expectations. So plans would come and go as NASA canceled projects. New projects would arise and the cycle would begin again. Repeatedly, NASA schedule and performance ambitions come up against costs growing at double-digit rates while budgets barely rise a couple of percent a year. Significant skepticism greets proposed NASA programs at birth, as cost estimates for new projects are traditionally very high, and worse, far off the mark for those carried forward. In this environment the current "capability driven framework" for NASA human spaceflight evolved, where long term life cycle cost analysis are even viewed as possibly counter-productive. Here, a space exploration project, for example the Space Launch System, focuses on immediate goals. A life cycle is that of a project, not a program, and for only that span of time to a near term milestone like a first test launch. Unfortunately, attempting to avoid some pitfalls in long-term life cycle cost analysis breeds others. Government audits have noted that limiting the scope of cost analysis "does not provide the transparency necessary to assess long-term affordability" making it difficult to understand if NASA "is progressing in a cost-effective and affordable manner." Even in this short-term framework, NASA realizes the importance of long-term considerations, that it must "maximize the efficiency and sustainability of the Exploration Systems development programs", that this is "critical to free resources for re-investment...such as other required deep space exploration capabilities." Assuming the value of long-term life cycle cost analysis, where due diligence meets reconnaissance, and accepting past shortcomings, the work here approaches life cycle cost analysis for human spaceflight differently. 1) If costs have traditionally been so high that adding them up is discouraging, are there any new facts on the ground offering paths to significantly lower costs? 2) If NASA's spaceflight budget and process is an over-arching constraint, with its planning limitations favoring short-term outlooks, is there a way to step outside the budget box? 3) If life cycle answers have historically been too uncertain to be useful, is there a process where stakeholders gain valuable insights merely from emphasizing a common understanding around questions? We analyze the potential life cycle cost of assorted NASA human spaceflight architectures - an architecture as a sum of individual systems, working together. With the prior questions of high costs, limited budgets and uncertainties in mind, public private partnerships are central in these architectures. The cost data for current commercial public private partnerships is encouraging, as are cost estimates for future partnership approaches beyond low Earth orbit. Private capital, directly or indirectly, an ingredient of public private partnerships, may be a significant factor in finding a path around the limits of the NASA spaceflight budget. Also, understanding and reviewing the pros, cons and uncertainties of assorted architectures can assist in developing a common understanding around key questions as important if not more so than the numbers and answers. Lastly, a scenario planning technique is briefly explored that can mature a common understanding about the agencies situation at hand and how diverse stakeholders can go forward together. Scenario planning, rather than focusing on answers, places emphasis on stakeholders developing a common understanding about the future. Putting aside costs, this is especially true of questions about sustainability and growth, results, benefits and expectations. While efficiency exercises or analysis look to reduce resources in one place to apply them elsewhere, moving around slices in a pie, scenario planning can get at the heart of the matter, growing the pie, transforming it, and making the pieces relevant. Especially important is the question of sustainability for different scenarios in the broad sense of the word - not just the narrow ability to survive or continue, but also the ability to adapt, prosper and grow.

Synthetic biology meets bioprinting: enabling technologies for humans on Mars (and Earth).

PubMed

Rothschild, Lynn J

2016-08-15

Human exploration off planet is severely limited by the cost of launching materials into space and by re-supply. Thus materials brought from Earth must be light, stable and reliable at destination. Using traditional approaches, a lunar or Mars base would require either transporting a hefty store of metals or heavy manufacturing equipment and construction materials for in situ extraction; both would severely limit any other mission objectives. Long-term human space presence requires periodic replenishment, adding a massive cost overhead. Even robotic missions often sacrifice science goals for heavy radiation and thermal protection. Biology has the potential to solve these problems because life can replicate and repair itself, and perform a wide variety of chemical reactions including making food, fuel and materials. Synthetic biology enhances and expands life's evolved repertoire. Using organisms as feedstock, additive manufacturing through bioprinting will make possible the dream of producing bespoke tools, food, smart fabrics and even replacement organs on demand. This new approach and the resulting novel products will enable human exploration and settlement on Mars, while providing new manufacturing approaches for life on Earth. © 2016 The Author(s).

Integrating Spaceflight Human System Risk Research

NASA Technical Reports Server (NTRS)

Mindock, Jennifer; Lumpkins, Sarah; Anton, Wilma; Havenhill, Maria; Shelhamer, Mark; Canga, Michael

2016-01-01

NASA is working to increase the likelihood of human health and performance success during exploration missions as well as to maintain the subsequent long-term health of the crew. To manage the risks in achieving these goals, a system modelled after a Continuous Risk Management framework is in place. "Human System Risks" (Risks) have been identified, and approximately 30 are being actively addressed by NASA's Human Research Program (HRP). Research plans for each of HRP's Risks have been developed and are being executed. Inter-disciplinary ties between the research efforts supporting each Risk have been identified; however, efforts to identify and benefit from these connections have been mostly ad hoc. There is growing recognition that solutions developed to address the full set of Risks covering medical, physiological, behavioural, vehicle, and organizational aspects of exploration missions must be integrated across Risks and disciplines. This paper discusses how a framework of factors influencing human health and performance in space is being applied as the backbone for bringing together sometimes disparate information relevant to the individual Risks. The resulting interrelated information enables identification and visualization of connections between Risks and research efforts in a systematic and standardized manner. This paper also discusses the applications of the visualizations and insights into research planning, solicitation, and decision-making processes.

Dosage-dependent non-linear effect of L-dopa on human motor cortex plasticity.

PubMed

Monte-Silva, Katia; Liebetanz, David; Grundey, Jessica; Paulus, Walter; Nitsche, Michael A

2010-09-15

The neuromodulator dopamine affects learning and memory formation and their likely physiological correlates, long-term depression and potentiation, in animals and humans. It is known from animal experiments that dopamine exerts a dosage-dependent, inverted U-shaped effect on these functions. However, this has not been explored in humans so far. In order to reveal a non-linear dose-dependent effect of dopamine on cortical plasticity in humans, we explored the impact of 25, 100 and 200 mg of L-dopa on transcranial direct current (tDCS)-induced plasticity in twelve healthy human subjects. The primary motor cortex served as a model system, and plasticity was monitored by motor evoked potential amplitudes elicited by transcranial magnetic stimulation. As compared to placebo medication, low and high dosages of L-dopa abolished facilitatory as well as inhibitory plasticity, whereas the medium dosage prolonged inhibitory plasticity, and turned facilitatory plasticity into inhibition. Thus the results show clear non-linear, dosage-dependent effects of dopamine on both facilitatory and inhibitory plasticity, and support the assumption of the importance of a specific dosage of dopamine optimally suited to improve plasticity. This might be important for the therapeutic application of dopaminergic agents, especially for rehabilitative purposes, and explain some opposing results in former studies.

How HRP Research Results Contribute to Human Space Exploration Risk Mitigation

NASA Technical Reports Server (NTRS)

Lumpkins, S. B.; Mindock, J. A.

2014-01-01

In addition to the scientific value of publications derived from research, results from Human Research Program (HRP) research also support HRP’s goals of mitigating crew health and performance risks in space flight. Research results are used to build the evidence base characterizing crew health and performance risks, to support risk research plan development, to inform crew health and performance standards, and to provide technologies to programs for meeting those standards and optimizing crew health and performance in space. This talk will describe examples of how research results support these efforts. For example, HRP research results are used to revise or even create new standards for human space flight, which have been established to protect crew health and performance during flight, and prevent negative long-term health consequences due to space flight. These standards are based on the best available clinical and scientific evidence, as well as operational experience from previous space flight missions, and are reviewed as new evidence emerges. Research results are also used to update the HRP evidence base, which is comprised of a set of reports that provide a current record of the state of knowledge from research and operations for each of the defined human health and performance risks for future NASA exploration missions. A discussion of the role of evidence within the HRP architecture will also be presented. The scope of HRP research results extends well beyond publications, as they are used in several capacities to support HRP deliverables and, ultimately, the advancement of human space exploration beyond low-Earth orbit.

How HRP Research Results Contribute to Human Space Exploration Risk Mitigation

NASA Technical Reports Server (NTRS)

Lumpkins, Sarah; Mindock, Jennifer

2014-01-01

In addition to the scientific value of publications derived from research, results from Human Research Program (HRP) research also support HRP's goals of mitigating crew health and performance risks in space flight. Research results are used to build the evidence base characterizing crew health and performance risks, to support risk research plan development, to inform crew health and performance standards, and to provide technologies to programs for meeting those standards and optimizing crew health and performance in space. This talk will describe examples of how research results support these efforts. For example, HRP research results are used to revise or even create new standards for human space flight, which have been established to protect crew health and performance during flight, and prevent negative long-term health consequences due to space flight. These standards are based on the best available clinical and scientific evidence, as well as operational experience from previous space flight missions, and are reviewed as new evidence emerges. Research results are also used to update the HRP evidence base, which is comprised of a set of reports that provide a current record of the state of knowledge from research and operations for each of the defined human health and performance risks for future NASA exploration missions. A discussion of the role of evidence within the HRP architecture will also be presented. The scope of HRP research results extends well beyond publications, as they are used in several capacities to support HRP deliverables and, ultimately, the advancement of human space exploration beyond low-Earth orbit.

Creating Communications, Computing, and Networking Technology Development Road Maps for Future NASA Human and Robotic Missions

NASA Technical Reports Server (NTRS)

Bhasin, Kul; Hayden, Jeffrey L.

2005-01-01

For human and robotic exploration missions in the Vision for Exploration, roadmaps are needed for capability development and investments based on advanced technology developments. A roadmap development process was undertaken for the needed communications, and networking capabilities and technologies for the future human and robotics missions. The underlying processes are derived from work carried out during development of the future space communications architecture, an d NASA's Space Architect Office (SAO) defined formats and structures for accumulating data. Interrelationships were established among emerging requirements, the capability analysis and technology status, and performance data. After developing an architectural communications and networking framework structured around the assumed needs for human and robotic exploration, in the vicinity of Earth, Moon, along the path to Mars, and in the vicinity of Mars, information was gathered from expert participants. This information was used to identify the capabilities expected from the new infrastructure and the technological gaps in the way of obtaining them. We define realistic, long-term space communication architectures based on emerging needs and translate the needs into interfaces, functions, and computer processing that will be required. In developing our roadmapping process, we defined requirements for achieving end-to-end activities that will be carried out by future NASA human and robotic missions. This paper describes: 10 the architectural framework developed for analysis; 2) our approach to gathering and analyzing data from NASA, industry, and academia; 3) an outline of the technology research to be done, including milestones for technology research and demonstrations with timelines; and 4) the technology roadmaps themselves.

Electrical Activity in Martian Dust Storms

NASA Astrophysics Data System (ADS)

Majid, W.; Arabshahi, S.; Kocz, J.

2016-12-01

Dust storms on Mars are predicted to be capable of producing electrostatic fields and discharges, even larger than those in dust storms on Earth. Such electrical activity poses serious risks to any Human exploration of the planet and the lack of sufficient data to characterize any such activity has been identified by NASA's MEPAG as a key human safety knowledge gap. There are three key elements in the characterization of Martian electrostatic discharges: dependence on Martian environmental conditions, frequency of occurrence, and the strength of the generated electric fields. We will describe a recently deployed detection engine using NASA's Deep Space Network (DSN) to carry out a long term monitoring campaign to search for and characterize the entire Mars hemisphere for powerful discharges during routine tracking of spacecraft at Mars on an entirely non-interfering basis. The resulting knowledge of Mars electrical activity would allow NASA to plan risk mitigation measures to ensure human safety during Mars exploration. In addition, these measurements will also allow us to place limits on presence of oxidants such as H2O2 that may be produced by such discharges, providing another measurement point for models describing Martian atmospheric chemistry and habitability. Because of the continuous Mars telecommunication needs of NASA's Mars-based assets, the DSN is the only instrument in the world that combines long term, high cadence, observing opportunities with large sensitive telescopes, making it a unique asset worldwide in searching for and characterizing electrostatic activity at Mars from the ground.

Radiation Transmission Properties of In-Situ Materials

NASA Technical Reports Server (NTRS)

Heilbronn, L.; Townsend, L. W.; Cucinotta, F.; Kim, M. Y.; Miller, J.; Singleterry, R.; Thibeault, S.; Wilson, J.; Zeitlin, C. J.

2001-01-01

The development of a permanent human presence in space is a key element of NASA's strategic plan for the Human Exploration and Development of Space (HEDS). The habitation of the International Space Station (ISS) is one near-term HEDS objective; the exploration and settlement of the moon and Mars are long-term goals of that plan. Achieving these goals requires maintaining the health and safety of personnel involved in such space operations at a high level, while at the same time reducing the cost of those operations to a reasonable level. Among the limiting factors to prolonged human space operations are the health risks from exposure to the space ionizing radiation environment. In order to keep the risk of radiation induced cancer at acceptable levels, it is necessary to provide adequate shielding from the ionizing radiation environment. The research presented here is theoretical and ground-based experimental study of the neutron production from interactions of GCR-like particles in various shielding components. An emphasis is placed here on research that will aid in the development of in-situ resource utilization. The primary goal of the program is to develop an accurate neutron-production model that is relevant to the NASA HEDS program of designing technologies that will be used in the development of effective shielding countermeasures. A secondary goal of the program is the development of an experimental data base of neutron production cross sections and thick-target yields which will aid model development.

The parietal cortices participate in encoding, short-term memory, and decision-making related to tactile shape.

PubMed

Rojas-Hortelano, Eduardo; Concha, Luis; de Lafuente, Victor

2014-10-15

We routinely identify objects with our hands, and the physical attributes of touched objects are often held in short-term memory to aid future decisions. However, the brain structures that selectively process tactile information to encode object shape are not fully identified. In this article we describe the areas within the human cerebral cortex that specialize in encoding, short-term memory, and decision-making related to the shape of objects explored with the hand. We performed event-related functional magnetic resonance imaging in subjects performing a shape discrimination task in which two sequentially presented objects had to be explored to determine whether they had the same shape or not. To control for low-level and nonspecific brain activations, subjects performed a temperature discrimination task in which they compared the temperature of two spheres. Our results show that although a large network of brain structures is engaged in somatosensory processing, it is the areas lining the intraparietal sulcus that selectively participate in encoding, maintaining, and deciding on tactile information related to the shape of objects. Copyright © 2014 the American Physiological Society.

Midlatitude Ice-Rich Ground on Mars: An Important Target for Science and In Situ Resource Utilization on Human Missions

NASA Technical Reports Server (NTRS)

Stoker, Carol; Heldmann, Jennifer

2015-01-01

The region of ROI is characterized by proven presence of near surface ground ice and numerous periglacial features. Midlatitude ground ice on Mars is of significant scientific interest for understanding the history and evolution of ice stability on Mars, the impact that changes in insolation produced by variations in Mars’ orbital parameters has on the regions climate, and could provide human exploration with a reliable and plentiful in situ resource. For both science and exploration, assessing the astrobiological potential of the ice is important in terms of (1) understanding the potential for life on Mars and (2) evaluating the presence of possible biohazards in advance of human exploration. Heldmann et al. (2014) studied locations on Mars in the Amazonis Planitia region where near surface ground ice was exposed by new impact craters (Byrne et al. 2009). The study examined whether sites in this region were suitable for human exploration including reviewing the evidence for midlatitude ground ice, discussing the possible explanations for its occurrence, assessing its potential habitability for modern life, and evaluating the resource potential. They systematically analyzed remote-sensing data sets to identify a viable landing site. Five sites where ground ice was exposed were examined with HiRise imaging and were classified according to (1) presence of polygons as a proxy for subsurface ice, (2) presence and abundance of rough topographic obstacles (e.g., large cracks, cliffs, uneven topography), (3) rock density, (4) presence and abundance of large boulders, and (5) presence of craters. A suitable landing site was found having ground ice at only 0.15m depth, and no landing site hazards within a 25 km landing ellipse. This paper presents results of that study and examines the relevance of this ROI to the workshop goals.

Paracrine Engineering of Human Cardiac Stem Cells With Insulin-Like Growth Factor 1 Enhances Myocardial Repair.

PubMed

Jackson, Robyn; Tilokee, Everad L; Latham, Nicholas; Mount, Seth; Rafatian, Ghazaleh; Strydhorst, Jared; Ye, Bin; Boodhwani, Munir; Chan, Vincent; Ruel, Marc; Ruddy, Terrence D; Suuronen, Erik J; Stewart, Duncan J; Davis, Darryl R

2015-09-11

Insulin-like growth factor 1 (IGF-1) activates prosurvival pathways and improves postischemic cardiac function, but this key cytokine is not robustly expressed by cultured human cardiac stem cells. We explored the influence of an enhanced IGF-1 paracrine signature on explant-derived cardiac stem cell-mediated cardiac repair. Receptor profiling demonstrated that IGF-1 receptor expression was increased in the infarct border zones of experimentally infarcted mice by 1 week after myocardial infarction. Human explant-derived cells underwent somatic gene transfer to overexpress human IGF-1 or the green fluorescent protein reporter alone. After culture in hypoxic reduced-serum media, overexpression of IGF-1 enhanced proliferation and expression of prosurvival transcripts and prosurvival proteins and decreased expression of apoptotic markers in both explant-derived cells and cocultured neonatal rat ventricular cardiomyocytes. Transplant of explant-derived cells genetically engineered to overexpress IGF-1 into immunodeficient mice 1 week after infarction boosted IGF-1 content within infarcted tissue and long-term engraftment of transplanted cells while reducing apoptosis and long-term myocardial scarring. Paracrine engineering of explant-derived cells to overexpress IGF-1 provided a targeted means of improving cardiac stem cell-mediated repair by enhancing the long-term survival of transplanted cells and surrounding myocardium. © 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

An Agent-Based Dynamic Model for Analysis of Distributed Space Exploration Architectures

NASA Astrophysics Data System (ADS)

Sindiy, Oleg V.; DeLaurentis, Daniel A.; Stein, William B.

2009-07-01

A range of complex challenges, but also potentially unique rewards, underlie the development of exploration architectures that use a distributed, dynamic network of resources across the solar system. From a methodological perspective, the prime challenge is to systematically model the evolution (and quantify comparative performance) of such architectures, under uncertainty, to effectively direct further study of specialized trajectories, spacecraft technologies, concept of operations, and resource allocation. A process model for System-of-Systems Engineering is used to define time-varying performance measures for comparative architecture analysis and identification of distinguishing patterns among interoperating systems. Agent-based modeling serves as the means to create a discrete-time simulation that generates dynamics for the study of architecture evolution. A Solar System Mobility Network proof-of-concept problem is introduced representing a set of longer-term, distributed exploration architectures. Options within this set revolve around deployment of human and robotic exploration and infrastructure assets, their organization, interoperability, and evolution, i.e., a system-of-systems. Agent-based simulations quantify relative payoffs for a fully distributed architecture (which can be significant over the long term), the latency period before they are manifest, and the up-front investment (which can be substantial compared to alternatives). Verification and sensitivity results provide further insight on development paths and indicate that the framework and simulation modeling approach may be useful in architectural design of other space exploration mass, energy, and information exchange settings.

Meditations on the new space vision: The moon as a stepping stone to mars

NASA Astrophysics Data System (ADS)

Mendell, W. W.

2005-07-01

The Vision for Space Exploration invokes activities on the Moon in preparation for exploration of Mars and also directs International Space Station (ISS) research toward the same goal. Lunar missions will emphasize development of capability and concomitant reduction of risk for future exploration of Mars. Earlier papers identified three critical issues related to the so-called NASA Mars Design Reference Mission (MDRM) to be addressed in the lunar context: (a) safety, health, and performance of the human crew; (b) various modalities of mission operations ranging surface activities to logistics, planning, and navigation; and (c) reliability and maintainability of systems in the planetary environment. In simple terms, lunar expeditions build a résumé that demonstrates the ability to design, construct, and operate an enterprise such as the MDRM with an expectation of mission success. We can evolve from Apollo-like missions to ones that resemble the complexity and duration of the MDRM. Investment in lunar resource utilization technologies falls naturally into the Vision. NASA must construct an exit strategy from the Moon in the third decade. With a mandate for continuing exploration, it cannot assume responsibility for long-term operation of lunar assets. Therefore, NASA must enter into a partnership with some other entity—governmental, international, or commercial—that can responsibly carry on lunar development past the exploration phase.

Meditations on the new space vision: the Moon as a stepping stone to Mars.

PubMed

Mendell, W W

2005-01-01

The Vision for Space Exploration invokes activities on the Moon in preparation for exploration of Mars and also directs International Space Station (ISS) research toward the same goal. Lunar missions will emphasize development of capability and concomitant reduction of risk for future exploration of Mars. Earlier papers identified three critical issues related to the so-called NASA Mars Design Reference Mission (MDRM) to be addressed in the lunar context: (a) safety, health, and performance of the human crew; (b) various modalities of mission operations ranging surface activities to logistics, planning, and navigation; and (c) reliability and maintainability of systems in the planetary environment. In simple terms, lunar expeditions build a résumé that demonstrates the ability to design, construct, and operate an enterprise such as the MDRM with an expectation of mission success. We can evolve from Apollo-like missions to ones that resemble the complexity and duration of the MDRM. Investment in lunar resource utilization technologies falls naturally into the Vision. NASA must construct an exit strategy from the Moon in the third decade. With a mandate for continuing exploration, it cannot assume responsibility for long-term operation of lunar assets. Therefore, NASA must enter into a partnership with some other entity--governmental, international, or commercial--that can responsibly carry on lunar development past the exploration phase. Published by Elsevier Ltd.

Species differences in tumour responses to cancer chemotherapy

PubMed Central

Lawrence, Jessica; Cameron, David; Argyle, David

2015-01-01

Despite advances in chemotherapy, radiotherapy and targeted drug development, cancer remains a disease of high morbidity and mortality. The treatment of human cancer patients with chemotherapy has become commonplace and accepted over the past 100 years. In recent years, and with a similar incidence of cancer to people, the use of cancer chemotherapy drugs in veterinary patients such as the dog has also become accepted clinical practice. The poor predictability of tumour responses to cancer chemotherapy drugs in rodent models means that the standard drug development pathway is costly, both in terms of money and time, leading to many drugs failing in Phase I and II clinical trials. This has led to the suggestion that naturally occurring cancers in pet dogs may offer an alternative model system to inform rational drug development in human oncology. In this review, we will explore the species variation in tumour responses to conventional chemotherapy and highlight our understanding of the differences in pharmacodynamics, pharmacokinetics and pharmacogenomics between humans and dogs. Finally, we explore the potential hurdles that need to be overcome to gain the greatest value from comparative oncology studies. PMID:26056373

Conceptual recurrence plots: revealing patterns in human discourse.

PubMed

Angus, Daniel; Smith, Andrew; Wiles, Janet

2012-06-01

Human discourse contains a rich mixture of conceptual information. Visualization of the global and local patterns within this data stream is a complex and challenging problem. Recurrence plots are an information visualization technique that can reveal trends and features in complex time series data. The recurrence plot technique works by measuring the similarity of points in a time series to all other points in the same time series and plotting the results in two dimensions. Previous studies have applied recurrence plotting techniques to textual data; however, these approaches plot recurrence using term-based similarity rather than conceptual similarity of the text. We introduce conceptual recurrence plots, which use a model of language to measure similarity between pairs of text utterances, and the similarity of all utterances is measured and displayed. In this paper, we explore how the descriptive power of the recurrence plotting technique can be used to discover patterns of interaction across a series of conversation transcripts. The results suggest that the conceptual recurrence plotting technique is a useful tool for exploring the structure of human discourse.

Software and Human-Machine Interface Development for Environmental Controls Subsystem Support

NASA Technical Reports Server (NTRS)

Dobson, Matthew

2018-01-01

The Space Launch System (SLS) is the next premier launch vehicle for NASA. It is the next stage of manned space exploration from American soil, and will be the platform in which we push further beyond Earth orbit. In preparation of the SLS maiden voyage on Exploration Mission 1 (EM-1), the existing ground support architecture at Kennedy Space Center required significant overhaul and updating. A comprehensive upgrade of controls systems was necessary, including programmable logic controller software, as well as Launch Control Center (LCC) firing room and local launch pad displays for technician use. Environmental control acts as an integral component in these systems, being the foremost system for conditioning the pad and extremely sensitive launch vehicle until T-0. The Environmental Controls Subsystem (ECS) required testing and modification to meet the requirements of the designed system, as well as the human factors requirements of NASA software for Validation and Verification (V&V). This term saw significant strides in the progress and functionality of the human-machine interfaces used at the launch pad, and improved integration with the controller code.

Role of VLA-4 and VLA-5 in ex vivo maintenance of human and pig hematopoiesis in human stroma-supported long-term cultures.

PubMed

Giovino, Maria A; Wang, Hui; Sykes, Megan; Yang, Yong-Guang

2005-03-01

The advantage of recipient hematopoiesis over that of xenogeneic donors poses a fundamental obstacle to the induction of xenograft tolerance through mixed hematopoietic chimerism. Here we explore the role of beta1 integrins in maintenance of human vs porcine hematopoiesis within a human hematopoietic environment. Porcine and human c-kit+ bone marrow cells were purified and cultured on human bone marrow stroma for 6 weeks. The role of VLA-4 and VLA-5 in the maintenance of porcine vs human hematopoiesis in this human stroma-supported long-term bone marrow culture (LTBMC) system was evaluated by using blocking mAbs that bind to both species. Blocking VLA-4 with HP2/1 inhibited both human and porcine hematopoiesis, whereas anti-VLA-5 (SAM-1) suppressed the function of human, but not porcine, hematopoietic cells. In mixed LTBMC of porcine and human cells on a human stroma, porcine hematopoietic cells were at a competitive disadvantage, as seen by a rapid decline in cellularity, including clonogenic progenitors. This disadvantage was substantially overcome by the addition of SAM-1. Furthermore, human, but not porcine, cell adhesion to human fibronectin was inhibited by arginine-glycine-aspartic acid (RGD) peptides. Taken together, these results indicate that VLA-4 plays critical role for porcine hematopoiesis in a human hematopoietic environment, and raise the possibility that porcine VLA-5 might be unable to bind the respective human ligand and/or to initiate adequate post-ligand-binding signaling. Thus, VLA-5 may provide a potential target for developing approaches to improve porcine hematopoiesis in human recipients.

Reflections on human presence in space

NASA Astrophysics Data System (ADS)

Arnould, Jacques

2001-08-01

Humankind's exploration of Space has until now been understood as analagous to that of planet Earth: sending out crews to far-off, unknown lands in the hope of finding supplies of food, water or energy along with shelter and living-space. But Space is turning out to be much less hospitable than our earthly milieu in terms of resources as well as energy costs. It seems appropriate to ask what level of adaptation is needed for humans to travel and live in the cosmos, and to assess if the next logical step should necessarily be a programme of conquest analagous to that of the Moon — for example, towards Mars. Should we not rather be making more use of Earth's immediate neighbourhood, namely the sphere of a million of kilometres we call "Greater Earth"? In the same way, it is appropriate to ask questions about the conception of human beings which will from now on sustain the conquest of Space. The astronaut of the last forty years is the direct heir of the explorers of Ancient and Modern times; now, through the influence of science and technology, humanity has been put "into motion" not only geographically, but also in its most essential foundations: culture, psychology, philosophy. If the development of telepresence technology now gives us the ability to talk about a "Greater Human Being", it is chiefly through freedom of choice for oneself, for humanity and even for Earth.

Peacocks, Picasso, and parental investment: The effects of romantic motives on creativity.

PubMed

Griskevicius, Vladas; Cialdini, Robert B; Kenrick, Douglas T

2006-07-01

Four experiments explored the effects of mating motivation on creativity. Even without other incentives to be creative, romantic motives enhanced creativity on subjective and objective measures. For men, any cue designed to activate a short-term or a long-term mating goal increased creative displays; however, women displayed more creativity only when primed to attract a high-quality long-term mate. These creative boosts were unrelated to increased effort on creative tasks or to changes in mood or arousal. Furthermore, results were unaffected by the application of monetary incentives for creativity. These findings align with the view that creative displays in both sexes may be linked to sexual selection, qualified by unique exigencies of human parental investment. Copyright 2006 APA, all rights reserved.

Mars Mapping Technology Brings Main Street to Life

NASA Technical Reports Server (NTRS)

2008-01-01

The Red Planet has long held a particular hold on the human psyche. From the Roman god of war to Orson Welles infamous Halloween broadcast, our nearest planetary neighbor has been viewed with curiosity, suspicion, and awe. Pictures of Mars from 1965 to the present reveal familiar landscapes while also challenging our perceptions and revising our understanding of the processes at work in planets. Frequent discoveries have forced significant revisions to previous theories. Although Mars shares many familiar features with Earth, such as mountains, plains, valleys, and polar ice, the conditions on Mars can vary wildly from those with which we are familiar. The apparently cold, rocky, and dusty wasteland seen through the eyes of spacecraft and Martian probes hints at a dynamic past of volcanic activity, cataclysmic meteors, and raging waters. New discoveries continue to revise our view of our next-door neighbor, and further exploration is now paving the way for a human sortie to the fourth stone from the Sun. NASA s Mars Exploration Program, a long-term effort of robotic exploration, utilizes wide-angle stereo cameras mounted on NASA s twin robot geologists, the Mars Exploration Rovers (MERs), launched in 2003. The rovers, named "Spirit" and "Opportunity," celebrated 4 Earth years of exploration on January 3, 2008, and have sent back a wealth of information on the terrain and composition of the Martian surface. Their marathon performance has far outlasted the intended 90 days of operation, and the two intrepid explorers promise more images and data.

KSC-04pd1307

NASA Image and Video Library

2004-06-17

KENNEDY SPACE CENTER, FLA. - In a plant growth chamber in the KSC Space Life Sciences Lab, plant physiologist Ray Wheeler checks radishes being grown using hydroponic techniques. Wheeler and other colleagues are researching plant growth under different types of light, different CO2 concentrations and temperatures. The Lab is exploring various aspects of a bioregenerative life support system. Such research and technology development will be crucial to long-term habitation of space by humans.

KSC-04pd1308

NASA Image and Video Library

2004-06-17

KENNEDY SPACE CENTER, FLA. - In a plant growth chamber in the KSC Space Life Sciences Lab, plant physiologist Ray Wheeler checks radishes being grown using hydroponic techniques. Wheeler and other colleagues are researching plant growth under different types of light, different CO2 concentrations and temperatures. The Lab is exploring various aspects of a bioregenerative life support system. Such research and technology development will be crucial to long-term habitation of space by humans.

KSC-04PD-1307

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. In a plant growth chamber in the KSC Space Life Sciences Lab, plant physiologist Ray Wheeler checks radishes being grown using hydroponic techniques. Wheeler and other colleagues are researching plant growth under different types of light, different CO2 concentrations and temperatures. The Lab is exploring various aspects of a bioregenerative life support system. Such research and technology development will be crucial to long-term habitation of space by humans.

KSC-04PD-1308

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. In a plant growth chamber in the KSC Space Life Sciences Lab, plant physiologist Ray Wheeler checks radishes being grown using hydroponic techniques. Wheeler and other colleagues are researching plant growth under different types of light, different CO2 concentrations and temperatures. The Lab is exploring various aspects of a bioregenerative life support system. Such research and technology development will be crucial to long-term habitation of space by humans.

Robots and Humans in Planetary Exploration: Working Together?

NASA Technical Reports Server (NTRS)

Landis, Geoffrey A.; Lyons, Valerie (Technical Monitor)

2002-01-01

Today's approach to human-robotic cooperation in planetary exploration focuses on using robotic probes as precursors to human exploration. A large portion of current NASA planetary surface exploration is focussed on Mars, and robotic probes are seen as precursors to human exploration in: Learning about operation and mobility on Mars; Learning about the environment of Mars; Mapping the planet and selecting landing sites for human mission; Demonstration of critical technology; Manufacture fuel before human presence, and emplace elements of human-support infrastructure

NASA Advanced Life Support Technology Testing and Development

NASA Technical Reports Server (NTRS)

Wheeler, Raymond M.

2012-01-01

Prior to 2010, NASA's advanced life support research and development was carried out primarily under the Exploration Life Support Project of NASA's Exploration Systems Mission Directorate. In 2011, the Exploration Life Support Project was merged with other projects covering Fire Prevention/Suppression, Radiation Protection, Advanced Environmental Monitoring and Control, and Thermal Control Systems. This consolidated project was called Life Support and Habitation Systems, which was managed under the Exploration Systems Mission Directorate. In 2012, NASA re-organized major directorates within the agency, which eliminated the Exploration Systems Mission Directorate and created the Office of the Chief Technologist (OCT). Life support research and development is currently conducted within the Office of the Chief Technologist, under the Next Generation Life Support Project, and within the Human Exploration Operation Missions Directorate under several Advanced Exploration System projects. These Advanced Exploration Systems projects include various themes of life support technology testing, including atmospheric management, water management, logistics and waste management, and habitation systems. Food crop testing is currently conducted as part of the Deep Space Habitation (DSH) project within the Advanced Exploration Systems Program. This testing is focused on growing salad crops that could supplement the crew's diet during near term missions.

The measurement of water scarcity: Defining a meaningful indicator.

PubMed

Damkjaer, Simon; Taylor, Richard

2017-09-01

Metrics of water scarcity and stress have evolved over the last three decades from simple threshold indicators to holistic measures characterising human environments and freshwater sustainability. Metrics commonly estimate renewable freshwater resources using mean annual river runoff, which masks hydrological variability, and quantify subjectively socio-economic conditions characterising adaptive capacity. There is a marked absence of research evaluating whether these metrics of water scarcity are meaningful. We argue that measurement of water scarcity (1) be redefined physically in terms of the freshwater storage required to address imbalances in intra- and inter-annual fluxes of freshwater supply and demand; (2) abandons subjective quantifications of human environments and (3) be used to inform participatory decision-making processes that explore a wide range of options for addressing freshwater storage requirements beyond dams that include use of renewable groundwater, soil water and trading in virtual water. Further, we outline a conceptual framework redefining water scarcity in terms of freshwater storage.

Microbial Monitoring of Crewed Habitats in Space—Current Status and Future Perspectives

PubMed Central

Yamaguchi, Nobuyasu; Roberts, Michael; Castro, Sarah; Oubre, Cherie; Makimura, Koichi; Leys, Natalie; Grohmann, Elisabeth; Sugita, Takashi; Ichijo, Tomoaki; Nasu, Masao

2014-01-01

Previous space research conducted during short-term flight experiments and long-term environmental monitoring on board orbiting space stations suggests that the relationship between humans and microbes is altered in the crewed habitat in space. Both human physiology and microbial communities adapt to spaceflight. Microbial monitoring is critical to crew safety in long-duration space habitation and the sustained operation of life support systems on space transit vehicles, space stations, and surface habitats. To address this critical need, space agencies including NASA (National Aeronautics and Space Administration), ESA (European Space Agency), and JAXA (Japan Aerospace Exploration Agency) are working together to develop and implement specific measures to monitor, control, and counteract biological contamination in closed-environment systems. In this review, the current status of microbial monitoring conducted in the International Space Station (ISS) as well as the results of recent microbial spaceflight experiments have been summarized and future perspectives are discussed. PMID:25130885

Relationship between inpatient satisfaction and nurse absenteeism: an exploratory study using WHO-PATH performance indicators in France

PubMed Central

2012-01-01

Background Indicators describing results of care are widely explored in term of patient satisfaction (PS). Among factors explaining PS, human resources indicators have been studied in terms of burnout or job satisfaction among healthcare professionals. No research work has set out to explore the effect of absenteeism on PS scores. The objective of this study was to explore interaction between rate of absenteeism among nurses and PS results. Methods France has taken part in a project named PATH (Performance Assessment Tool for Hospitals) of the World Health Organization, aiming to develop a tool for the assessment of hospital performance. In the first semester 2008, 25 volunteering short-stay hospitals (teaching, general and private) provide complete data on nurse short-absenteeism (periods of up to 7 consecutive days of sick leave) and on PS (a cross-sectional postal survey using a standardized validated French-language scale EQS-H exploring "quality of medical information" (MI) and "relationships with staff and daily routine" (RS)). A multi-level model was used to take into account of the hierarchical nature of the data. Results Two thousand and sixty-five patients responded to the satisfaction questionnaire (participation rate: 40.9%). The mean age of respondents was 58 yrs (± 19), 41% were men. The mean duration of hospitalisation was 7.5 days (± 11.1). The mean absenteeism rate for nurses was 0.24% (± 0.14). All the PS scores were significantly and negatively correlated with rate of short-absenteeism among nurses (MI score: ρ = -0.55, p < 0.01), RS score ρ = -0.47, p = 0.02). The mixed model found a significant relationship between rate of absenteeism among nurses and PS scores (MI: p = 0.027; RS: p = 0.017). Conclusion Results obtained in this study show that short-term absenteeism among nurses seems to be significantly and negatively correlated with PS. Our findings are an invitation to deepen our understanding of the impact of human resources on PS and to develop more specific projects. PMID:22293709

Relationship between inpatient satisfaction and nurse absenteeism: an exploratory study using WHO-PATH performance indicators in France.

PubMed

Moret, Leila; Anthoine, Emmanuelle; Paillé, Cécile; Tricaud-Vialle, Sophie; Gerbaud, Laurent; Giraud-Roufast, Alexandra; Michel, Philippe; Lombrail, Pierre

2012-01-31

Indicators describing results of care are widely explored in term of patient satisfaction (PS). Among factors explaining PS, human resources indicators have been studied in terms of burnout or job satisfaction among healthcare professionals. No research work has set out to explore the effect of absenteeism on PS scores. The objective of this study was to explore interaction between rate of absenteeism among nurses and PS results. France has taken part in a project named PATH (Performance Assessment Tool for Hospitals) of the World Health Organization, aiming to develop a tool for the assessment of hospital performance. In the first semester 2008, 25 volunteering short-stay hospitals (teaching, general and private) provide complete data on nurse short-absenteeism (periods of up to 7 consecutive days of sick leave) and on PS (a cross-sectional postal survey using a standardized validated French-language scale EQS-H exploring "quality of medical information" (MI) and "relationships with staff and daily routine" (RS)). A multi-level model was used to take into account of the hierarchical nature of the data. Two thousand and sixty-five patients responded to the satisfaction questionnaire (participation rate: 40.9%). The mean age of respondents was 58 yrs (± 19), 41% were men. The mean duration of hospitalisation was 7.5 days (± 11.1). The mean absenteeism rate for nurses was 0.24% (± 0.14).All the PS scores were significantly and negatively correlated with rate of short-absenteeism among nurses (MI score: ρ = -0.55, p < 0.01), RS score ρ = -0.47, p = 0.02). The mixed model found a significant relationship between rate of absenteeism among nurses and PS scores (MI: p = 0.027; RS: p = 0.017). Results obtained in this study show that short-term absenteeism among nurses seems to be significantly and negatively correlated with PS. Our findings are an invitation to deepen our understanding of the impact of human resources on PS and to develop more specific projects.

Foraging under conditions of short-term exploitative competition: the case of stock traders.

PubMed

Saavedra, Serguei; Malmgren, R Dean; Switanek, Nicholas; Uzzi, Brian

2013-03-22

Theory purports that animal foraging choices evolve to maximize returns, such as net energy intake. Empirical research in both human and non-human animals reveals that individuals often attend to the foraging choices of their competitors while making their own foraging choices. Owing to the complications of gathering field data or constructing experiments, however, broad facts relating theoretically optimal and empirically realized foraging choices are only now emerging. Here, we analyse foraging choices of a cohort of professional day traders who must choose between trading the same stock multiple times in a row--patch exploitation--or switching to a different stock--patch exploration--with potentially higher returns. We measure the difference between a trader's resource intake and the competitors' expected intake within a short period of time--a difference we call short-term comparative returns. We find that traders' choices can be explained by foraging heuristics that maximize their daily short-term comparative returns. However, we find no one-best relationship between different trading choices and net income intake. This suggests that traders' choices can be short-term win oriented and, paradoxically, maybe maladaptive for absolute market returns.

Biosentinel: Developing a Space Radiation Biosensor

NASA Technical Reports Server (NTRS)

Santa Maria, Sergio R.; Marina, Diana B.; Parra, Macarena P.; Boone, Travis D.; Tan, Ming; Ricco, Antonio J.; Straume, Tore N.; Lusby, Terry C.; Harkness, T.; Reiss-Bubenheim, Debra;

Toward a definition of affective instability.

PubMed

Renaud, Suzane M; Zacchia, Camillo

2012-01-01

Affective instability is a psychophysiological symptom observed in some psychopathologies. It is a complex construct that encompasses (1) primary emotions, or affects, and secondary emotions, with each category having its own characteristics, amplitude, and duration, (2) rapid shifting from neutral or valenced affect to intense affect, and (3) dysfunctional modulation of emotions. Affective instability is often confused with mood lability, as in bipolar disorders, as well as with other terms. To clarify the concept, we searched databases for the term affective instability and read related articles on the topic. In this article we situate the term within the current affective nomenclature and human emotional experience, explore its psychophysiological features, and place it within the context of psychopathology. We explain why the term can potentially be confused with mood pathology and then define affective instability as an inherited temperamental trait modulated by developmental experience.

“That’s a good question”: University researchers’ views on ownership and retention of human genetic specimens

PubMed Central

Cadigan, R. Jean; Easter, Michele M.; Dobson, Allison W.; Davis, Arlene M.; Rothschild, Barbra B.; Zimmer, Catherine; Sterling, Rene; Henderson, Gail

2012-01-01

Purpose To explore the views of university-based investigators conducting genetic research with human specimens regarding ownership and retention of specimens, and knowledge of related institutional review board and university policies. Methods Data were collected in three phases: a qualitative pilot study of 14 investigators; a web-based survey taken by 80 investigators; and follow-up, in-depth interviews with 12 survey respondents. Results Investigators named a variety of single or multiple owners of human specimens and often expressed confusion regarding specimen ownership. Most associated ownership with rights to control, and responsibilities to maintain, specimens. Investigators viewed specimens as “precious” resources whose value could be increased through long-term or infinite retention, particularly in light of anticipated technological advances in genome science. Their views on ownership and retention were shaped by perceptions of institutional review board policies as immortalized in subject informed consent documents, rather than knowledge of actual policies. Conclusion Long-term retention of human specimens makes confusion about ownership particularly problematic. Given findings that investigators’ views on ownership and retention are largely guided by their perception of university policies, the need for clear, consistent policies at the institution level is urgent. PMID:21659952

Proteomic Analysis of Hair Follicles

NASA Astrophysics Data System (ADS)

Ishioka, Noriaki; Terada, Masahiro; Yamada, Shin; Seki, Masaya; Takahashi, Rika; Majima, Hideyuki J.; Higashibata, Akira; Mukai, Chiaki

2013-02-01

Hair root cells actively divide in a hair follicle, and they sensitively reflect physical conditions. By analyzing the human hair, we can know stress levels on the human body and metabolic conditions caused by microgravity environment and cosmic radiation. The Japan Aerospace Exploration Agency (JAXA) has initiated a human research study to investigate the effects of long-term space flight on gene expression and mineral metabolism by analyzing hair samples of astronauts who stayed in the International Space Station (ISS) for 6 months. During long-term flights, the physiological effects on astronauts include muscle atrophy and bone calcium loss. Furthermore, radiation and psychological effects are important issue to consider. Therefore, an understanding of the effects of the space environment is important for developing countermeasures against the effects experienced by astronauts. In this experiment, we identify functionally important target proteins that integrate transcriptome, mineral metabolism and proteome profiles from human hair. To compare the protein expression data with the gene expression data from hair roots, we developed the protein processing method. We extracted the protein from five strands of hair using ISOGEN reagents. Then, these extracted proteins were analyzed by LC-MS/MS. These collected profiles will give us useful physiological information to examine the effect of space flight.

Rethinking the medical in the medical humanities.

PubMed

O'Neill, Desmond; Jenkins, Elinor; Mawhinney, Rebecca; Cosgrave, Ellen; O'Mahony, Sarah; Guest, Clare; Moss, Hilary

2016-06-01

To clinicians there are a number of striking features of the ever-evolving field of the medical humanities. The first is a perception of a predominantly unidirectional relationship between medicine and the humanities, generally in terms of what the arts and humanities have to offer medicine. The second is the portrayal of medical practice in terms of problems and negativities for which the medical humanities are seen to pose the solution rather than viewing medicine as an active and positive contributor to an interdisciplinary project. Paradigms that fail to recognise the contributions of medicine and its practitioners (including students) to the medical humanities, this paper argues, will continue to struggle with definition and acceptance. This paper explores the possibilities for advancing the medical humanities through recognition of the contribution of medicine to the humanities and the importance of engaging with the arts, culture and leisure pursuits of doctors and medical students. Our research shows the richness of cultural engagement of medical students, their broad range of cultural interests and their ability to contribute to research and scholarship in the medical humanities. Mutual recognition of strengths, weaknesses and differences of scholarly approach is critical to successful development of the enterprise. Recognising and building on the interests, sympathies and contributions of medicine and its practitioners to the medical humanities is a fundamental component of this task. Future directions might include introductory courses for humanities scholars in aspects of healthcare and medicine. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Global analysis of human duplicated genes reveals the relative importance of whole-genome duplicates originated in the early vertebrate evolution.

PubMed

Acharya, Debarun; Ghosh, Tapash C

2016-01-22

Gene duplication is a genetic mutation that creates functionally redundant gene copies that are initially relieved from selective pressures and may adapt themselves to new functions with time. The levels of gene duplication may vary from small-scale duplication (SSD) to whole genome duplication (WGD). Studies with yeast revealed ample differences between these duplicates: Yeast WGD pairs were functionally more similar, less divergent in subcellular localization and contained a lesser proportion of essential genes. In this study, we explored the differences in evolutionary genomic properties of human SSD and WGD genes, with the identifiable human duplicates coming from the two rounds of whole genome duplication occurred early in vertebrate evolution. We observed that these two groups of duplicates were also dissimilar in terms of their evolutionary and genomic properties. But interestingly, this is not like the same observed in yeast. The human WGDs were found to be functionally less similar, diverge more in subcellular level and contain a higher proportion of essential genes than the SSDs, all of which are opposite from yeast. Additionally, we explored that human WGDs were more divergent in their gene expression profile, have higher multifunctionality and are more often associated with disease, and are evolutionarily more conserved than human SSDs. Our study suggests that human WGD duplicates are more divergent and entails the adaptation of WGDs to novel and important functions that consequently lead to their evolutionary conservation in the course of evolution.

Space Exploration Supply Chain Modeling, Simulation and Analysis Using the SCOR Model

NASA Technical Reports Server (NTRS)

Zapata, Edgar; Callinan, Mike; Fayez, Sam

2006-01-01

sustained and affordable human and robotic program to explore the solar system and beyond. Extend human presence across the solar system, starting with a human return to the Moon by the year 2020, in preparation for human exploration of Mars and other destinations. Develop the innovative technologies, knowledge, and infrastructure both to explore and to support decisions about the destinations for human exploration; and promote international and commercial participation in exploration to further U.S. scientific, security, and economic interests

ESA's Earth Observation Programmes in the Changing Anthropocene

NASA Astrophysics Data System (ADS)

Liebig, Volker

2016-07-01

The intervention will present ESA's Earth Observation programmes and their relevance to studying the anthropocene. ESA's Earth observation missions are mainly grouped into three categories: The Sentinel satellites in the context of the European Copernicus Programme, the scientific Earth Explorers and the meteorological missions. Developments, applications and scientific results for the different mission types will be addressed, along with overall trends and strategies. The Earth Explorers, who form the science and research element of ESA's Living Planet Programme, focus on the atmosphere, biosphere, hydrosphere, cryosphere and Earth's interior. The Earth Explorers also aim at learning more about the interactions between these components and the impact that human activity is having on natural Earth processes. The Sentinel missions provide accurate, timely, long term and uninterrupted data to provide key information services, improving the way the environment is managed, and helping to mitigate the effects of climate change. The operational Sentinel satellites can also be exploited for scientific studies of the anthropocene. In the anthropocene human activities affect the whole planet and space is a very efficient means to measure their impact, but for relevant endeavours to be successful they can only be carried out in international cooperation. ESA maintains long-standing partnerships with other space agencies and institutions worldwide. In running its Earth observation programmes, ESA responds to societal needs and challenges and to requirements resulting from political priorities set by decision makers. Activities related to Climate Change are a prime example. Within ESA's Climate Change Initiative, 13 Essential Climate Variables are constantly monitored to create a long-term record of key geophysical parameters.

Evaluation of helper-dependent canine adenovirus vectors in a 3D human CNS model

PubMed Central

Simão, Daniel; Pinto, Catarina; Fernandes, Paulo; Peddie, Christopher J.; Piersanti, Stefania; Collinson, Lucy M.; Salinas, Sara; Saggio, Isabella; Schiavo, Giampietro; Kremer, Eric J.; Brito, Catarina; Alves, Paula M.

2017-01-01

Gene therapy is a promising approach with enormous potential for treatment of neurodegenerative disorders. Viral vectors derived from canine adenovirus type 2 (CAV-2) present attractive features for gene delivery strategies in the human brain, by preferentially transducing neurons, are capable of efficient axonal transport to afferent brain structures, have a 30-kb cloning capacity and have low innate and induced immunogenicity in pre-clinical tests. For clinical translation, in-depth pre-clinical evaluation of efficacy and safety in a human setting is primordial. Stem cell-derived human neural cells have a great potential as complementary tools by bridging the gap between animal models, which often diverge considerably from human phenotype, and clinical trials. Herein, we explore helper-dependent CAV-2 (hd-CAV-2) efficacy and safety for gene delivery in a human stem cell-derived 3D neural in vitro model. Assessment of hd-CAV-2 vector efficacy was performed at different multiplicities of infection, by evaluating transgene expression and impact on cell viability, ultrastructural cellular organization and neuronal gene expression. Under optimized conditions, hd-CAV-2 transduction led to stable long-term transgene expression with minimal toxicity. hd-CAV-2 preferentially transduced neurons, while human adenovirus type 5 (HAdV5) showed increased tropism towards glial cells. This work demonstrates, in a physiologically relevant 3D model, that hd-CAV-2 vectors are efficient tools for gene delivery to human neurons, with stable long-term transgene expression and minimal cytotoxicity. PMID:26181626

Evaluation of helper-dependent canine adenovirus vectors in a 3D human CNS model.

PubMed

Simão, D; Pinto, C; Fernandes, P; Peddie, C J; Piersanti, S; Collinson, L M; Salinas, S; Saggio, I; Schiavo, G; Kremer, E J; Brito, C; Alves, P M

2016-01-01

Gene therapy is a promising approach with enormous potential for treatment of neurodegenerative disorders. Viral vectors derived from canine adenovirus type 2 (CAV-2) present attractive features for gene delivery strategies in the human brain, by preferentially transducing neurons, are capable of efficient axonal transport to afferent brain structures, have a 30-kb cloning capacity and have low innate and induced immunogenicity in preclinical tests. For clinical translation, in-depth preclinical evaluation of efficacy and safety in a human setting is primordial. Stem cell-derived human neural cells have a great potential as complementary tools by bridging the gap between animal models, which often diverge considerably from human phenotype, and clinical trials. Herein, we explore helper-dependent CAV-2 (hd-CAV-2) efficacy and safety for gene delivery in a human stem cell-derived 3D neural in vitro model. Assessment of hd-CAV-2 vector efficacy was performed at different multiplicities of infection, by evaluating transgene expression and impact on cell viability, ultrastructural cellular organization and neuronal gene expression. Under optimized conditions, hd-CAV-2 transduction led to stable long-term transgene expression with minimal toxicity. hd-CAV-2 preferentially transduced neurons, whereas human adenovirus type 5 (HAdV5) showed increased tropism toward glial cells. This work demonstrates, in a physiologically relevant 3D model, that hd-CAV-2 vectors are efficient tools for gene delivery to human neurons, with stable long-term transgene expression and minimal cytotoxicity.

Learning and exploration in action-perception loops.

PubMed

Little, Daniel Y; Sommer, Friedrich T

2013-01-01

Discovering the structure underlying observed data is a recurring problem in machine learning with important applications in neuroscience. It is also a primary function of the brain. When data can be actively collected in the context of a closed action-perception loop, behavior becomes a critical determinant of learning efficiency. Psychologists studying exploration and curiosity in humans and animals have long argued that learning itself is a primary motivator of behavior. However, the theoretical basis of learning-driven behavior is not well understood. Previous computational studies of behavior have largely focused on the control problem of maximizing acquisition of rewards and have treated learning the structure of data as a secondary objective. Here, we study exploration in the absence of external reward feedback. Instead, we take the quality of an agent's learned internal model to be the primary objective. In a simple probabilistic framework, we derive a Bayesian estimate for the amount of information about the environment an agent can expect to receive by taking an action, a measure we term the predicted information gain (PIG). We develop exploration strategies that approximately maximize PIG. One strategy based on value-iteration consistently learns faster than previously developed reward-free exploration strategies across a diverse range of environments. Psychologists believe the evolutionary advantage of learning-driven exploration lies in the generalized utility of an accurate internal model. Consistent with this hypothesis, we demonstrate that agents which learn more efficiently during exploration are later better able to accomplish a range of goal-directed tasks. We will conclude by discussing how our work elucidates the explorative behaviors of animals and humans, its relationship to other computational models of behavior, and its potential application to experimental design, such as in closed-loop neurophysiology studies.

Human Biomechanical and Cardiopulmonary Responses to Partial Gravity - A Systematic Review.

PubMed

Richter, Charlotte; Braunstein, Bjoern; Winnard, Andrew; Nasser, Mona; Weber, Tobias

2017-01-01

The European Space Agency has recently announced to progress from low Earth orbit missions on the International Space Station to other mission scenarios such as exploration of the Moon or Mars. Therefore, the Moon is considered to be the next likely target for European human space explorations. Compared to microgravity (μg), only very little is known about the physiological effects of exposure to partial gravity (μg < partial gravity <1 g). However, previous research studies and experiences made during the Apollo missions comprise a valuable source of information that should be taken into account when planning human space explorations to reduced gravity environments. This systematic review summarizes the different effects of partial gravity (0.1-0.4 g) on the human musculoskeletal, cardiovascular and respiratory systems using data collected during the Apollo missions as well as outcomes from terrestrial models of reduced gravity with either 1 g or microgravity as a control. The evidence-based findings seek to facilitate decision making concerning the best medical and exercise support to maintain astronauts' health during future missions in partial gravity. The initial search generated 1,323 publication hits. Out of these 1,323 publications, 43 studies were included into the present analysis and relevant data were extracted. None of the 43 included studies investigated long-term effects. Studies investigating the immediate effects of partial gravity exposure reveal that cardiopulmonary parameters such as heart rate, oxygen consumption, metabolic rate, and cost of transport are reduced compared to 1 g, whereas stroke volume seems to increase with decreasing gravity levels. Biomechanical studies reveal that ground reaction forces, mechanical work, stance phase duration, stride frequency, duty factor and preferred walk-to-run transition speed are reduced compared to 1 g. Partial gravity exposure below 0.4 g seems to be insufficient to maintain musculoskeletal and cardiopulmonary properties in the long-term. To compensate for the anticipated lack of mechanical and metabolic stimuli some form of exercise countermeasure appears to be necessary in order to maintain reasonable astronauts' health, and thus ensure both sufficient work performance and mission safety.

Human Biomechanical and Cardiopulmonary Responses to Partial Gravity – A Systematic Review

PubMed Central

Richter, Charlotte; Braunstein, Bjoern; Winnard, Andrew; Nasser, Mona; Weber, Tobias

2017-01-01

The European Space Agency has recently announced to progress from low Earth orbit missions on the International Space Station to other mission scenarios such as exploration of the Moon or Mars. Therefore, the Moon is considered to be the next likely target for European human space explorations. Compared to microgravity (μg), only very little is known about the physiological effects of exposure to partial gravity (μg < partial gravity <1 g). However, previous research studies and experiences made during the Apollo missions comprise a valuable source of information that should be taken into account when planning human space explorations to reduced gravity environments. This systematic review summarizes the different effects of partial gravity (0.1–0.4 g) on the human musculoskeletal, cardiovascular and respiratory systems using data collected during the Apollo missions as well as outcomes from terrestrial models of reduced gravity with either 1 g or microgravity as a control. The evidence-based findings seek to facilitate decision making concerning the best medical and exercise support to maintain astronauts' health during future missions in partial gravity. The initial search generated 1,323 publication hits. Out of these 1,323 publications, 43 studies were included into the present analysis and relevant data were extracted. None of the 43 included studies investigated long-term effects. Studies investigating the immediate effects of partial gravity exposure reveal that cardiopulmonary parameters such as heart rate, oxygen consumption, metabolic rate, and cost of transport are reduced compared to 1 g, whereas stroke volume seems to increase with decreasing gravity levels. Biomechanical studies reveal that ground reaction forces, mechanical work, stance phase duration, stride frequency, duty factor and preferred walk-to-run transition speed are reduced compared to 1 g. Partial gravity exposure below 0.4 g seems to be insufficient to maintain musculoskeletal and cardiopulmonary properties in the long-term. To compensate for the anticipated lack of mechanical and metabolic stimuli some form of exercise countermeasure appears to be necessary in order to maintain reasonable astronauts' health, and thus ensure both sufficient work performance and mission safety. PMID:28860998

Introduction to the special focus issue on the impact of diet on gut microbiota composition and function and future opportunities for nutritional modulation of the gut microbiome to improve human health.

PubMed

Donovan, Sharon M

2017-03-04

Over the past decade, application of culture-independent, next generation DNA sequencing has dramatically enhanced our understanding of the composition of the gut microbiome and its association with human states of health and disease. Host genetics, age, and environmental factors such as where and who you live with, use of pre-, pro- and antibiotics, exercise and diet influence the short- and long-term composition of the microbiome. Dietary intake is a key determinant of microbiome composition and diversity and studies to date have linked long-term dietary patterns as well as short-term dietary interventions to the composition and diversity of the gut microbiome. The goal of this special focus issue was to review the role of diet in regulating the composition and function of the gut microbiota across the lifespan, from pregnancy to old age. Overall dietary patterns, as well as perturbations such as undernutrition and obesity, as well as the effects of dietary fiber/prebiotics and fat composition are explored.

A spatio-temporal model for estimating the long-term effects of air pollution on respiratory hospital admissions in Greater London.

PubMed

Rushworth, Alastair; Lee, Duncan; Mitchell, Richard

2014-07-01

It has long been known that air pollution is harmful to human health, as many epidemiological studies have been conducted into its effects. Collectively, these studies have investigated both the acute and chronic effects of pollution, with the latter typically based on individual level cohort designs that can be expensive to implement. As a result of the increasing availability of small-area statistics, ecological spatio-temporal study designs are also being used, with which a key statistical problem is allowing for residual spatio-temporal autocorrelation that remains after the covariate effects have been removed. We present a new model for estimating the effects of air pollution on human health, which allows for residual spatio-temporal autocorrelation, and a study into the long-term effects of air pollution on human health in Greater London, England. The individual and joint effects of different pollutants are explored, via the use of single pollutant models and multiple pollutant indices. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

National Space Biomedical Research Institute

NASA Technical Reports Server (NTRS)

2003-01-01

In June 1996, NASA released a Cooperative Agreement Notice (CAN) inviting proposals to establish a National Space Biomedical Research Institute (9-CAN-96-01). This CAN stated that: The Mission of the Institute will be to lead a National effort for accomplishing the integrated, critical path, biomedical research necessary to support the long term human presence, development, and exploration of space and to enhance life on Earth by applying the resultant advances in human knowledge and technology acquired through living and working in space. The Institute will be the focal point of NASA sponsored space biomedical research. This statement has not been amended by NASA and remains the mission of the NSBRI.

Control Automation in Undersea Search and Manipulation

NASA Technical Reports Server (NTRS)

Weltman, Gershon; Freedy, Amos

1974-01-01

Automatic decision making and control mechanisms of the type termed "adaptive" or "intelligent" offer unique advantages for exploration and manipulation of the undersea environment, particularly at great depths. Because they are able to carry out human-like functions autonomously, such mechanisms can aid and extend the capabilities of the human operator. This paper reviews past and present work in the areas of adaptive control and robotics with the purpose of establishing logical guidelines for the application of automatic techniques underwater. Experimental research data are used to illustrate the importance of information feedback, personnel training, and methods of control allocation in the interaction between operator and intelligent machine.

Midlatitude ice-rich ground on mars as a target in the search for evidence of life and for in situ resource utilization on human missions.

PubMed

Heldmann, J L; Schurmeier, L; McKay, C; Davila, A; Stoker, C; Marinova, M; Wilhelm, M B

2014-02-01

Midlatitude ground ice on Mars is of significant scientific interest for understanding the history and evolution of ice stability on Mars and is relevant for human exploration as a possible in situ resource. For both science and exploration, assessing the astrobiological potential of the ice is important in terms of (1) understanding the potential for life on Mars and (2) evaluating the presence of possible biohazards in advance of human exploration. In the present study, we review the evidence for midlatitude ground ice on Mars, discuss the possible explanations for its occurrence, and assess its potential habitability. During the course of study, we systematically analyzed remote-sensing data sets to determine whether a viable landing site exists in the northern midlatitudes to enable a robotic mission that conducts in situ characterization and searches for evidence of life in the ice. We classified each site according to (1) presence of polygons as a proxy for subsurface ice, (2) presence and abundance of rough topographic obstacles (e.g., large cracks, cliffs, uneven topography), (3) rock density, (4) presence and abundance of large boulders, and (5) presence of craters. We found that a suitable landing site exists within Amazonis Planitia near ground ice that was recently excavated by a meteorite impact.

The pharmacology of neuroplasticity induced by non-invasive brain stimulation: building models for the clinical use of CNS active drugs

PubMed Central

Nitsche, Michael A; Müller-Dahlhaus, Florian; Paulus, Walter; Ziemann, Ulf

2012-01-01

The term neuroplasticity encompasses structural and functional modifications of neuronal connectivity. Abnormal neuroplasticity is involved in various neuropsychiatric diseases, such as dystonia, epilepsy, migraine, Alzheimer's disease, fronto-temporal degeneration, schizophrenia, and post cerebral stroke. Drugs affecting neuroplasticity are increasingly used as therapeutics in these conditions. Neuroplasticity was first discovered and explored in animal experimentation. However, non-invasive brain stimulation (NIBS) has enabled researchers recently to induce and study similar processes in the intact human brain. Plasticity induced by NIBS can be modulated by pharmacological interventions, targeting ion channels, or neurotransmitters. Importantly, abnormalities of plasticity as studied by NIBS are directly related to clinical symptoms in neuropsychiatric diseases. Therefore, a core theme of this review is the hypothesis that NIBS-induced plasticity can explore and potentially predict the therapeutic efficacy of CNS-acting drugs in neuropsychiatric diseases. We will (a) review the basics of neuroplasticity, as explored in animal experimentation, and relate these to our knowledge about neuroplasticity induced in humans by NIBS techniques. We will then (b) discuss pharmacological modulation of plasticity in animals and humans. Finally, we will (c) review abnormalities of plasticity in neuropsychiatric diseases, and discuss how the combination of NIBS with pharmacological intervention may improve our understanding of the pathophysiology of abnormal plasticity in these diseases and their purposeful pharmacological treatment. PMID:22869014

Explore with Us

NASA Technical Reports Server (NTRS)

Morales, Lester

2012-01-01

The fundamental goal of this vision is to advance U.S. scientific, security and economic interest through a robust space exploration program. Implement a sustained and affordable human and robotic program to explore the solar system and beyond. Extend human presence across the solar system, starting with a human return to the Moon by the year 2020, in preparation for human exploration of Mars and other destinations. Develop the innovative technologies, knowledge, and infrastructures both to explore and to support decisions about the destinations for human exploration. Promote international and commercial participation in exploration to further U.S. scientific, security, and economic interests.

Nitrate and nitrite in the diet: how to assess their benefit and risk for human health.

PubMed

Habermeyer, Michael; Roth, Angelika; Guth, Sabine; Diel, Patrick; Engel, Karl-Heinz; Epe, Bernd; Fürst, Peter; Heinz, Volker; Humpf, Hans-Ulrich; Joost, Hans-Georg; Knorr, Dietrich; de Kok, Theo; Kulling, Sabine; Lampen, Alfonso; Marko, Doris; Rechkemmer, Gerhard; Rietjens, Ivonne; Stadler, Richard H; Vieths, Stefan; Vogel, Rudi; Steinberg, Pablo; Eisenbrand, Gerhard

2015-01-01

Nitrate is a natural constituent of the human diet and an approved food additive. It can be partially converted to nitrogen monoxide, which induces vasodilation and thereby decreases blood pressure. This effect is associated with a reduced risk regarding cardiovascular disease, myocardial infarction, and stroke. Moreover, dietary nitrate has been associated with beneficial effects in patients with gastric ulcer, renal failure, or metabolic syndrome. Recent studies indicate that such beneficial health effects due to dietary nitrate may be achievable at intake levels resulting from the daily consumption of nitrate-rich vegetables. N-nitroso compounds are endogenously formed in humans. However, their relevance for human health has not been adequately explored up to now. Nitrate and nitrite are per se not carcinogenic, but under conditions that result in endogenous nitrosation, it cannot be excluded that ingested nitrate and nitrite may lead to an increased cancer risk and may probably be carcinogenic to humans. In this review, the known beneficial and detrimental health effects related to dietary nitrate/nitrite intake are described and the identified gaps in knowledge as well as the research needs required to perform a reliable benefit/risk assessment in terms of long-term human health consequences due to dietary nitrate/nitrite intake are presented. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Examining the Resilience of Crop Production, Livestock Carrying Capacity, and Woodland Density in a Rural Zimbabwean Socio-Ecological System Using Agent-Based Models Representing Human Management Decisions

NASA Astrophysics Data System (ADS)

Eitzel Solera, M. V.; Neves, K.; Veski, A.; Solera, J.; Omoju, O. E.; Mawere Ndlovu, A.; Wilson, K.

2016-12-01

As climate change increases the pressures on arid ecosystems by changing timing and amount of rainfall, understanding the ways in which human management choices affect the resilience of these systems becomes key to their sustainability. On marginal farmland in Mazvihwa, Midlands Province, the historical carrying capacity of livestock has been consistently surprisingly high. We explore this phenomenon by building an agent-based model in NetLogo from a wealth of long-term data generated by the community-based participatory research team of The Muonde Trust, a Zimbabwean non-governmental organization. We combine the accumulated results of 35 years of indigenous and local knowledge with national datasets such as rainfall records. What factors keep the carrying capacity high? What management choices can maintain crops, livestock, and woodland at levels necessary for the community's survival? How do these choices affect long-term sustainability, and does increasing resilience at one scale reduce resilience at another scale? We use our agent-based model to explore the feedbacks between crops, livestock, and woodland and the impacts of various human choices as well as temporal and spatial ecological variation. By testing different scenarios, we disentangle the complex interactions between these components. We find that some factors out of the community's control can strongly affect the sustainability of the system through times of drought, and that supplementary feed may maintain livestock potentially at the expense of other resources. The challenges to resilience encountered by the farmers in Mazvihwa are not unique - many indigenous and rural people face drought and the legacies of colonialism, which contribute to lowered resilience to external challenges such as climate change, epidemics, and political instability. Using the agent-based model as a tool for synthesis and exploration initiates discussion about resilience-enhancing management choices for Mazvihwa's farmer-researchers.

InfAcrOnt: calculating cross-ontology term similarities using information flow by a random walk.

PubMed

Cheng, Liang; Jiang, Yue; Ju, Hong; Sun, Jie; Peng, Jiajie; Zhou, Meng; Hu, Yang

2018-01-19

Since the establishment of the first biomedical ontology Gene Ontology (GO), the number of biomedical ontology has increased dramatically. Nowadays over 300 ontologies have been built including extensively used Disease Ontology (DO) and Human Phenotype Ontology (HPO). Because of the advantage of identifying novel relationships between terms, calculating similarity between ontology terms is one of the major tasks in this research area. Though similarities between terms within each ontology have been studied with in silico methods, term similarities across different ontologies were not investigated as deeply. The latest method took advantage of gene functional interaction network (GFIN) to explore such inter-ontology similarities of terms. However, it only used gene interactions and failed to make full use of the connectivity among gene nodes of the network. In addition, all existent methods are particularly designed for GO and their performances on the extended ontology community remain unknown. We proposed a method InfAcrOnt to infer similarities between terms across ontologies utilizing the entire GFIN. InfAcrOnt builds a term-gene-gene network which comprised ontology annotations and GFIN, and acquires similarities between terms across ontologies through modeling the information flow within the network by random walk. In our benchmark experiments on sub-ontologies of GO, InfAcrOnt achieves a high average area under the receiver operating characteristic curve (AUC) (0.9322 and 0.9309) and low standard deviations (1.8746e-6 and 3.0977e-6) in both human and yeast benchmark datasets exhibiting superior performance. Meanwhile, comparisons of InfAcrOnt results and prior knowledge on pair-wise DO-HPO terms and pair-wise DO-GO terms show high correlations. The experiment results show that InfAcrOnt significantly improves the performance of inferring similarities between terms across ontologies in benchmark set.

Human Mars Landing Site and Impacts on Mars Surface Operations

NASA Technical Reports Server (NTRS)

Hoffman, Stephen J.; Bussey, Ben

2016-01-01

This paper describes NASA's initial steps for identifying and evaluating candidate Exploration Zones (EZs) and Regions of Interests (ROIs) for the first human crews that will explore the surface of Mars. NASA's current effort to define the exploration of this planet by human crews, known as the Evolvable Mars Campaign (EMC), provides the context in which these EZs and ROIs are being considered. The EMC spans all aspects of a human Mars mission including launch from Earth, transit to and from Mars, and operations on the surface of Mars. An EZ is a collection of ROIs located within approximately 100 kilometers of a centralized landing site. ROIs are areas relevant for scientific investigation and/or development/maturation of capabilities and resources necessary for a sustainable human presence. The EZ also contains one or more landing sites and a habitation site that will be used by multiple human crews during missions to explore and utilize the ROIs within the EZ. With the EMC as a conceptual basis, the EZ model has been refined to a point where specific site selection criteria for scientific exploration and in situ resource utilization can be defined. In 2015 these criteria were distributed to the planetary sciences community and the in situ resource utilization and civil engineering communities as part of a call for EZ proposals. The resulting "First Landing Site/Exploration Zone Workshop for Human Missions to the Surface of Mars" was held in October 2015 during which 47 proposals for EZs and ROIs were presented and discussed. Proposed locations spanned all longitudes and all allowable latitudes (+/- 50 degrees). Proposed justification for selecting one of these EZs also spanned a significant portion of the scientific and resource criteria provided to the community. Several important findings resulted from this Workshop including: (a) a strong consensus that, at a scale of 100 km (radius), multiple places on Mars exist that have both sufficient scientific interest to sustain multiple crews of exploring astronauts, AND potential resource deposits for ISRU indicating the current EZ definition is viable and should be retained for now, (b) new data types (needed for more definitive analysis of EZs) argued strongly for a new orbiter mission, and possibly one or more surface missions, to obtain these data, (c) a general consensus that this Workshop was an excellent start to identifying a place where future human missions to Mars can productively explore this planet and learn to live and work there for the long term. Building on these findings, HEOMD and SMD are: (a) refining the EZ selection criteria and overall selection process to improve on lessons learned from the first EZ workshop, (b) using these proposed locations to develop "reference EZs" for assessment purposes (primarily engineering assessments), (c) gathering data and conducting analyses to better understanding the different potential sources for water, including the ease of extraction and purification, and (d) assessing trends in additional data that are needed to better characterize EZs proposed at the workshop and how these data needs impact the design and operation of future robotic Mars missions.

Universe exploration vision

NASA Technical Reports Server (NTRS)

O'Handley, D.; Swan, P.; Sadeh, W.

1992-01-01

U.S. space policy is discussed in terms of present and planned activities in the solar system and beyond to develop a concept for expanding space travel. The history of space exploration is briefly reviewed with references to the Mariner II, Apollo, and Discoverer programs. Attention is given to the issues related to return trips to the moon, sprint vs repetitive missions to Mars, and the implications of propulsion needs. The concept of terraforming other bodies within the solar system so that they can support human activity is identified as the next major phase of exploration. The following phase is considered to be the use of robotic or manned missions that extend beyond the solar system. Reference is given to a proposed Thousand Astronomical Units mission as a precursor to exploratory expansion into the universe, and current robotic mission activities are mentioned.

Exploring MEDLINE Space with Random Indexing and Pathfinder Networks

PubMed Central

Cohen, Trevor

2008-01-01

The integration of disparate research domains is a prerequisite for the success of the translational science initiative. MEDLINE abstracts contain content from a broad range of disciplines, presenting an opportunity for the development of methods able to integrate the knowledge they contain. Latent Semantic Analysis (LSA) and related methods learn human-like associations between terms from unannotated text. However, their computational and memory demands limits their ability to address a corpus of this size. Furthermore, visualization methods previously used in conjunction with LSA have limited ability to define the local structure of the associative networks LSA learns. This paper explores these issues by (1) processing the entire MEDLINE corpus using Random Indexing, a variant of LSA, and (2) exploring learned associations using Pathfinder Networks. Meaningful associations are inferred from MEDLINE, including a drug-disease association undetected by PUBMED search. PMID:18999236

Space exploration and colonization - Towards a space faring society

NASA Technical Reports Server (NTRS)

Hammond, Walter E.

1990-01-01

Development trends of space exploration and colonization since 1957 are reviewed, and a five-phase evolutionary program planned for the long-term future is described. The International Geosphere-Biosphere program which is intended to provide the database on enviromental changes of the earth as a global system is considered. Evolution encompasses the anticipated advantages of such NASA observation projects as the Hubble Space Telescope, the Gamma Ray Observatory, the Advanced X-Ray Astrophysics Facility, and the Cosmic Background Explorer. Attention is given to requirements for space colonization, including development of artificial gravity and countermeasures to mitigate zero gravity problems; robotics and systems aimed to minimize human exposure to the space environment; the use of nuclear propulsion; and international collaboration on lunar-Mars projects. It is recommended that nuclear energy sources be developed for both propulsion and as extraterrestrial power plants.

Exploring MEDLINE space with random indexing and pathfinder networks.

PubMed

Cohen, Trevor

2008-11-06

The integration of disparate research domains is a prerequisite for the success of the translational science initiative. MEDLINE abstracts contain content from a broad range of disciplines, presenting an opportunity for the development of methods able to integrate the knowledge they contain. Latent Semantic Analysis (LSA) and related methods learn human-like associations between terms from unannotated text. However, their computational and memory demands limits their ability to address a corpus of this size. Furthermore, visualization methods previously used in conjunction with LSA have limited ability to define the local structure of the associative networks LSA learns. This paper explores these issues by (1) processing the entire MEDLINE corpus using Random Indexing, a variant of LSA, and (2) exploring learned associations using Pathfinder Networks. Meaningful associations are inferred from MEDLINE, including a drug-disease association undetected by PUBMED search.

What's in a Name?-Consequences of Naming Non-Human Animals.

PubMed

Borkfelt, Sune

2011-01-19

The act of naming is among the most basic actions of language. Indeed, it is naming something that enables us to communicate about it in specific terms, whether the object named is human or non-human, animate or inanimate. However, naming is not as uncomplicated as we may usually think and names have consequences for the way we think about animals (human and non-human), peoples, species, places, things etc. Through a blend of history, philosophy and representational theory-and using examples from, among other things, the Bible, Martin Luther, colonialism/imperialism and contemporary ways of keeping and regarding non-human animals-this paper attempts to trace the importance of (both specific and generic) naming to our relationships with the non-human. It explores this topic from the naming of the animals in Genesis to the names given and used by scientists, keepers of companion animals, media etc. in our societies today, and asks the question of what the consequences of naming non-human animals are for us, for the beings named and for the power relations between our species and the non-human species and individuals we name.

Relativistic Spacecraft Propelled by Directed Energy

NASA Astrophysics Data System (ADS)

Kulkarni, Neeraj; Lubin, Philip; Zhang, Qicheng

2018-04-01

Achieving relativistic flight to enable extrasolar exploration is one of the dreams of humanity and the long-term goal of our NASA Starlight program. We derive a relativistic solution for the motion of a spacecraft propelled by radiation pressure from a directed energy (DE) system. Depending on the system parameters, low-mass spacecraft can achieve relativistic speeds, thus enabling interstellar exploration. The diffraction of the DE system plays an important role and limits the maximum speed of the spacecraft. We consider “photon recycling” as a possible method to achieving higher speeds. We also discuss recent claims that our previous work on this topic is incorrect and show that these claims arise from an improper treatment of causality.

Layered Metals Fabrication Technology Development for Support of Lunar Exploration at NASA/MSFC

NASA Technical Reports Server (NTRS)

Cooper, Kenneth G.; Good, James E.; Gilley, Scott D.

2007-01-01

NASA's human exploration initiative poses great opportunity and risk for missions to the Moon and beyond. In support of these missions, engineers and scientists at the Marshall Space Flight Center are developing technologies for ground-based and in-situ fabrication capabilities utilizing provisioned and locally-refined materials. Development efforts are pushing state-of-the art fabrication technologies to support habitat structure development, tools and mechanical part fabrication, as well as repair and replacement of ground support and space mission hardware such as life support items, launch vehicle components and crew exercise equipment. This paper addresses current fabrication technologies relative to meeting targeted capabilities, near term advancement goals, and process certification of fabrication methods.

Highly efficient generation of glutamatergic/cholinergic NT2-derived postmitotic human neurons by short-term treatment with the nucleoside analogue cytosine β-D-arabinofuranoside.

PubMed

González-Burguera, Imanol; Ricobaraza, Ana; Aretxabala, Xabier; Barrondo, Sergio; García del Caño, Gontzal; López de Jesús, Maider; Sallés, Joan

2016-03-01

The human NTERA2/D1 (NT2) cells generate postmitotic neurons (NT2N cells) upon retinoic acid (RA) treatment and are functionally integrated in the host tissue following grafting into the rodent and human brain, thus representing a promising source for neuronal replacement therapy. Yet the major limitations of this model are the lengthy differentiation procedure and its low efficiency, although recent studies suggest that the differentiation process can be shortened to less than 1 week using nucleoside analogues. To explore whether short-term exposure of NT2 cells to the nucleoside analogue cytosine β-d-arabinofuranoside (AraC) could be a suitable method to efficiently generate mature neurons, we conducted a neurochemical and morphometric characterization of AraC-differentiated NT2N (AraC/NT2N) neurons and improved the differentiation efficiency by modifying the cell culture schedule. Moreover, we analyzed the neurotransmitter phenotypes of AraC/NT2N neurons. Cultures obtained by treatment with AraC were highly enriched in postmitotic neurons and essentially composed of dual glutamatergic/cholinergic neurons, which contrasts with the preferential GABAergic phenotype that we found after RA differentiation. Taken together, our results further reinforce the notion NT2 cells are a versatile source of neuronal phenotypes and provide a new encouraging platform for studying mechanisms of neuronal differentiation and for exploring neuronal replacement strategies. Copyright © 2016 University of Texas at Austin Dell Medical School. Published by Elsevier B.V. All rights reserved.

Health-risk based approach to setting drinking water standards for long-term space missions

NASA Technical Reports Server (NTRS)

Macler, Bruce A.; Dunsky, Elizabeth C.

1992-01-01

In order to develop plausible and appropriate drinking water contaminant standards for longer-term NASA space missions, such as those planned for the Space Exploration Initiative, a human health risk characterization was performed using toxicological and exposure values typical of space operations and crew. This risk characterization showed that the greatest acute waterborne health concern was from microbial infection leading to incapacitating gastrointestinal illness. Ingestion exposure pathways for toxic materials yielded de minimus acute health risks unlikely to affect SEI space missions. Risks of chronic health problems were within acceptable public health limits. Our analysis indicates that current Space Station Freedom maximum contamination levels may be unnecessarily strict. We propose alternative environmental contaminant values consistent with both acceptable short and long-term crew health safety.

Microgravity Materials Research and Code U ISRU

NASA Technical Reports Server (NTRS)

Curreri, Peter A.; Sibille, Laurent

2004-01-01

The NASA microgravity research program, simply put, has the goal of doing science (which is essentially finding out something previously unknown about nature) utilizing the unique long-term microgravity environment in Earth orbit. Since 1997 Code U has in addition funded scientific basic research that enables safe and economical capabilities to enable humans to live, work and do science beyond Earth orbit. This research has been integrated with the larger NASA missions (Code M and S). These new exploration research focus areas include Radiation Shielding Materials, Macromolecular Research on Bone and Muscle Loss, In Space Fabrication and Repair, and Low Gravity ISRU. The latter two focus on enabling materials processing in space for use in space. The goal of this program is to provide scientific and technical research resulting in proof-of-concept experiments feeding into the larger NASA program to provide humans in space with an energy rich, resource rich, self sustaining infrastructure at the earliest possible time and with minimum risk, launch mass and program cost. President Bush's Exploration Vision (1/14/04) gives a new urgency for the development of ISRU concepts into the exploration architecture. This will require an accelerated One NASA approach utilizing NASA's partners in academia, and industry.

KSC-08pd0153

NASA Image and Video Library

2008-02-01

KENNEDY SPACE CENTER, FLA. -- After signing a framework agreement establishing the terms for future cooperation between NASA and the Indian Space Research Organization, Chairman G. Madhavan Nair (center) is given a tour of the Space Station Processing Facility at NASA's Kennedy Space Center. The agreement establishes the terms for future cooperation between the two agencies in the exploration and use of outer space for peaceful purposes. According to the framework agreement, the two agencies will identify areas of mutual interest and seek to develop cooperative programs or projects in Earth and space science, exploration, human space flight and other activities. In addition to a long history of cooperation in Earth science, NASA and the Indian Space Research Organization also are cooperating on India's first, mission to the moon, Chandrayaan-1, which will be launched later this year. NASA is providing two of the 11 instruments on the spacecraft: the moon mineralogy mapper instrument and the miniature synthetic aperture radar instrument. Photo credit: NASA/Kim Shiflett

KSC-08pd0150

NASA Image and Video Library

2008-02-01

KENNEDY SPACE CENTER, FLA. -- After signing a framework agreement establishing the terms for future cooperation between NASA and the Indian Space Research Organization, Chairman G. Madhavan Nair (center) and other members are given a tour of the Space Station Processing Facility at NASA's Kennedy Space Center. The agreement establishes the terms for future cooperation between the two agencies in the exploration and use of outer space for peaceful purposes. According to the framework agreement, the two agencies will identify areas of mutual interest and seek to develop cooperative programs or projects in Earth and space science, exploration, human space flight and other activities. In addition to a long history of cooperation in Earth science, NASA and the Indian Space Research Organization also are cooperating on India's first, mission to the moon, Chandrayaan-1, which will be launched later this year. NASA is providing two of the 11 instruments on the spacecraft: the moon mineralogy mapper instrument and the miniature synthetic aperture radar instrument. Photo credit: NASA/Kim Shiflett

KSC-08pd0152

NASA Image and Video Library

2008-02-01

KENNEDY SPACE CENTER, FLA. -- After signing a framework agreement establishing the terms for future cooperation between NASA and the Indian Space Research Organization, Chairman G. Madhavan Nair (center) and other members are given a tour of the Space Station Processing Facility at NASA's Kennedy Space Center. The agreement establishes the terms for future cooperation between the two agencies in the exploration and use of outer space for peaceful purposes. According to the framework agreement, the two agencies will identify areas of mutual interest and seek to develop cooperative programs or projects in Earth and space science, exploration, human space flight and other activities. In addition to a long history of cooperation in Earth science, NASA and the Indian Space Research Organization also are cooperating on India's first, mission to the moon, Chandrayaan-1, which will be launched later this year. NASA is providing two of the 11 instruments on the spacecraft: the moon mineralogy mapper instrument and the miniature synthetic aperture radar instrument. Photo credit: NASA/Kim Shiflett

KSC-08pd0151

NASA Image and Video Library

2008-02-01

KENNEDY SPACE CENTER, FLA. -- After signing a framework agreement establishing the terms for future cooperation between NASA and the Indian Space Research Organization, Chairman G. Madhavan Nair (center) and other members are given a tour of the Space Station Processing Facility at NASA's Kennedy Space Center. The agreement establishes the terms for future cooperation between the two agencies in the exploration and use of outer space for peaceful purposes. According to the framework agreement, the two agencies will identify areas of mutual interest and seek to develop cooperative programs or projects in Earth and space science, exploration, human space flight and other activities. In addition to a long history of cooperation in Earth science, NASA and the Indian Space Research Organization also are cooperating on India's first, mission to the moon, Chandrayaan-1, which will be launched later this year. NASA is providing two of the 11 instruments on the spacecraft: the moon mineralogy mapper instrument and the miniature synthetic aperture radar instrument. Photo credit: NASA/Kim Shiflett

Computer-based Learning of Neuroanatomy: A Longitudinal Study of Learning, Transfer, and Retention

PubMed Central

Chariker, Julia H.; Naaz, Farah; Pani, John R.

2013-01-01

A longitudinal experiment was conducted to evaluate the effectiveness of new methods for learning neuroanatomy with computer-based instruction. Using a 3D graphical model of the human brain, and sections derived from the model, tools for exploring neuroanatomy were developed to encourage adaptive exploration. This is an instructional method which incorporates graphical exploration in the context of repeated testing and feedback. With this approach, 72 participants learned either sectional anatomy alone or whole anatomy followed by sectional anatomy. Sectional anatomy was explored either with perceptually continuous navigation through the sections or with discrete navigation (as in the use of an anatomical atlas). Learning was measured longitudinally to a high performance criterion. Subsequent tests examined transfer of learning to the interpretation of biomedical images and long-term retention. There were several clear results of this study. On initial exposure to neuroanatomy, whole anatomy was learned more efficiently than sectional anatomy. After whole anatomy was mastered, learners demonstrated high levels of transfer of learning to sectional anatomy and from sectional anatomy to the interpretation of complex biomedical images. Learning whole anatomy prior to learning sectional anatomy led to substantially fewer errors overall than learning sectional anatomy alone. Use of continuous or discrete navigation through sectional anatomy made little difference to measured outcomes. Efficient learning, good long-term retention, and successful transfer to the interpretation of biomedical images indicated that computer-based learning using adaptive exploration can be a valuable tool in instruction of neuroanatomy and similar disciplines. PMID:23349552

Outpost in Jovian system - a stepwise long-term undertaking

NASA Astrophysics Data System (ADS)

Yasaka, Tetsuo

2003-11-01

Space has been attracting human attention since the dawn of our history, and clues thus given have triggered scientific and cultural evolutions. Now the space is in our hands. Near earth space has been developed, providing benefits to daily life. Moon and Mars will become the stage of human activity in a few decades. What will be the next logical step? The next step should be an undertaking that promises substantial influence to human history, both in knowledge and productive activities. Looking into the future directions of technology development combined with their outcome, Kyushu University selected a stepwise long-term undertaking toward establishment of an outpost in the Jovian system. Jupiter is our closest gas planet, which is a replica of the Sun. Its true understanding is essential to our knowledge of the universe. Its satellites abounds versatility providing not only the crucial knowledge of science but energy and materials vital to space activities. Jovian outpost consists of the central station on or around Callisto, controlling several laboratories on other Galilean satellites and dispatching probes to the main planet including Jovian-Crafts to cruise within its atmosphere and Deep Probes to explore the depth of the hydrogen ocean. Utilization of materials especially water on Europa will enable energy management of the stations and probes, and will further provide sound base toward exploration of the outskirts of the solar system and beyond. This understanding needs a long term endeavor that should be handed over many generations. This is a technology development program but education is an essential part of the process. The task is based on a series of short (5 year) targets. Each target provides stepwise solution to the objective, yet provides substantial outputs to the society and industries in a timely manner. The paper describes the overall program and details of the first 5 year targets.

Outpost in Jovian system—a stepwise long-term undertaking

NASA Astrophysics Data System (ADS)

Yasaka, Tetsuo

2006-10-01

Space has been attracting human attention since the dawn of our history, and clues thus given have triggered scientific and cultural evolutions. Now the space is in our hands. Near earth space has been developed, providing benefits to daily life. Moon and Mars will become the stage of human activity in a few decades. What will be the next logical step? The next step should be an undertaking that promises substantial influence to human history, both in knowledge and productive activities. Looking into the future directions of technology development combined with their outcome, Kyushu University selected a stepwise long-term undertaking toward establishment of an outpost in the Jovian system. Jupiter is our closest gas planet, which is a replica of the Sun. Its true understanding is essential to our knowledge of the universe. Its satellites abounds versatility providing not only the crucial knowledge of science but energy and materials vital to space activities. Jovian outpost consists of the central station on or around Callisto, controlling several laboratories on other Galilean satellites and dispatching probes to the main planet including Jovian-Crafts to cruise within its atmosphere and Deep Probes to explore the depth of the hydrogen ocean. Utilization of materials especially water on Europa will enable energy management of the stations and probes, and will further provide sound base toward exploration of the outskirts of the solar system and beyond. This understanding needs a long-term endeavor that should be handed over many generations. This is a technology development program but education is an essential part of the process. The task is based on a series of short (5 year) targets. Each target provides stepwise solution to the objective, yet provides substantial outputs to the society and industries in a timely manner. The paper describes the overall program and details of the first 5 year targets.

Historical Perspective on the Rise and Fall and Rise of Antibiotics and Human Weight Gain.

PubMed

Podolsky, Scott H

2017-01-17

In recent medical and popular literature, audiences have been asked to consider whether antibiotics have contributed to the rising obesity epidemic. Prominent magazines have stated that weight may be adversely affected by antibiotics that destroy existing microbiomes and replace them with less helpful ones. However, there is a long history of efforts to investigate the relationship between antibiotics and human weight gain. In the early 1950s, amid initial findings that low doses of antibiotics served as growth promoters in animal livestock, investigators explored the role of antibiotics as magic bullets for human malnutrition. Nevertheless, early enthusiasm was tempered by controlled studies showing that antibiotics did not serve as useful, nonspecific growth promoters for humans. In subsequent decades, against the backdrop of rising concern over antibiotic resistance, investigators studying the role of antibiotics in acute malnutrition have had to navigate a more complicated public health calculus. In a related historical stream, scientists since the 1910s have explored the role of the intestinal microflora in human health. By the 2000s, as increasing resources and more sophisticated tools were devoted to understanding the microbiome (a term coined in 2001), attention would turn to the role of antibiotics and the intestinal microflora in the rising obesity epidemic. Despite scientific and commercial enthusiasm, easy answers (whether about antibiotics or probiotics) have again given way to an appreciation for the complexity of human growth. History encourages caution about our hopes for simplistic answers for presumed "fat drugs" and slimming probiotics alike.

Reflections on human presence in space.

PubMed

Arnould, J

2001-01-01

Humankind's exploration of Space has until now been understood as analogous to that of planet Earth: sending out crews to far-off, unknown lands in the hope of finding supplies of food, water or energy along with shelter and living-space. But Space is turning out to be much less hospitable than our earthly milieu in terms of resources as well as energy costs. It seems appropriate to ask what level of adaptation is needed for humans to travel and live in the cosmos, and to assess if the next logical step should necessarily be a programme of conquest analogous to that of the Moon--for example, towards Mars. Should we not rather be making more use of Earth's immediate neighbourhood, namely the sphere of a million of kilometres we call "Greater Earth"? In the same way, it is appropriate to ask questions about the conception of human beings which will from now on sustain the conquest of Space. The astronaut of the last forty years is the direct heir of the explorers of Ancient and Modern times; now, through the influence of science and technology, humanity has been put "into motion" not only geographically, but also in its most essential foundations: culture, psychology, philosophy. If the development of telepresence technology now gives us the ability to talk about a "Greater Human Being", it is chiefly through freedom of choice for oneself, for humanity and even for Earth. c 2001. Elsevier Science Ltd. All rights reserved.

Science for the sustainable use of ecosystem services

PubMed Central

Bennett, Elena M.; Chaplin-Kramer, Rebecca

2016-01-01

Sustainability is a key challenge for humanity in the 21st century. Ecosystem services—the benefits that people derive from nature and natural capital—is a concept often used to help explain human reliance on nature and frame the decisions we make in terms of the ongoing value of nature to human wellbeing. Yet ecosystem service science has not always lived up to the promise of its potential. Despite advances in the scientific literature, ecosystem service science has not yet answered some of the most critical questions posed by decision-makers in the realm of sustainability. Here, we explore the history of ecosystem service science, discuss advances in conceptualization and measurement, and point toward further work needed to improve the use of ecosystem service in decisions about sustainable development. PMID:27853527

A Blueprint of an International Lunar Robotic Village

NASA Technical Reports Server (NTRS)

Alkalai, Leon

2012-01-01

Human civilization is destined to look, find and develop a second habitable destination in our Solar System, besides Earth: Moon and Mars are the two most likely and credible places based on proximity, available local resources and economics Recent international missions have brought back valuable information on both Moon and Mars. The vision is: A permanent presence on the Moon using advanced robotic systems as precursors to the future human settlement of the Moon is possible in the near-term. An international effort should be initiated to create a permanent robotic village to demonstrate and validate advanced technologies and systems across international boundaries, conduct broad science, explore new regions of the Moon and Mars, develop infrastructure, human habitats and shelters, facilitate development of commerce and stimulate public involvement and education.

Testing a measure of organizational learning capacity and readiness for transformational change in human services.

PubMed

Bess, Kimberly D; Perkins, Douglas D; McCown, Diana L

2011-01-01

Transformative organizational change requires organizational learning capacity, which we define in terms of (1) internal and (2) external organizational systems alignment, and promoting a culture of learning, including (3) an emphasis on exploration and information, (4) open communication, (5) staff empowerment, and (6) support for professional development. We shortened and adapted Watkins and Marsick's Dimensions of Learning Organizations Questionnaire into a new 16-item Organizational Learning Capacity Scale (OLCS) geared more toward nonprofit organizations. The OLCS and its subscales measuring each of the above 6 dimensions are unusually reliable for their brevity. ANOVAs for the OLCS and subscales clearly and consistently confirmed extensive participant observations and other qualitative data from four nonprofit human service organizations and one local human service funding organization.

Sex differences in cell genesis, hippocampal volume and behavioral outcomes in a rat model of neonatal HI

PubMed Central

Waddell, Jaylyn; Hanscom, Marie; Edwards, N. Shalon; McKenna, Mary C.; McCarthy, Margaret M.

2015-01-01

Hypoxia ischemia (HI) of the brain in near-term and term infants is a leading cause of infant mortality and lifelong disability but current therapeutic approaches remain limited. Males consistently display greater vulnerability to the deleterious consequences of HI in both humans and animal models. Neurogenesis increases after neonatal HI and offers a potential therapeutic target for recovery. The steroid hormone estradiol has been extensively explored as a neuroprotectant in adult models of stroke but with mixed results. Less consideration has been afforded to this naturally occurring agent in the developing brain, which has unique challenges from the adult. Using a model of term HI in the rat we have explored the impact of this insult on cell genesis in the hippocampus of males and females and the ability of estradiol treatment immediately after insult to restore function. Both short-term (3 days) and long-term (7 days) post-injury were assessed and revealed that only females had markedly increased cell genesis on the short-term but both sexes were increased long-term. A battery of behavioral tests revealed motor impairment in males and compromised episodic memory while both sexes were modestly impaired in spatial memory. Juvenile social play was also depressed in both sexes after HI. Estradiol therapy improved behavioral performance in both sexes but did not reverse a deficit in hippocampal volume ipsilateral to the insult. Thus the effects of estradiol do not appear to be via cell death or proliferation but rather involve other components of neural functioning. PMID:26376217

Sex differences in cell genesis, hippocampal volume and behavioral outcomes in a rat model of neonatal HI.

PubMed

Waddell, Jaylyn; Hanscom, Marie; Shalon Edwards, N; McKenna, Mary C; McCarthy, Margaret M

2016-01-01

Hypoxia-ischemia (HI) of the brain in near-term and term infants is a leading cause of infant mortality and lifelong disability but current therapeutic approaches remain limited. Males consistently display greater vulnerability to the deleterious consequences of HI in both humans and animal models. Neurogenesis increases after neonatal HI and offers a potential therapeutic target for recovery. The steroid hormone estradiol has been extensively explored as a neuroprotectant in adult models of stroke but with mixed results. Less consideration has been afforded to this naturally occurring agent in the developing brain, which has unique challenges from the adult. Using a model of term HI in the rat we have explored the impact of this insult on cell genesis in the hippocampus of males and females and the ability of estradiol treatment immediately after insult to restore function. Both short-term (3 days) and long-term (7 days) post-injury were assessed and revealed that only females had markedly increased cell genesis on the short-term but both sexes were increased long-term. A battery of behavioral tests revealed motor impairment in males and compromised episodic memory while both sexes were modestly impaired in spatial memory. Juvenile social play was also depressed in both sexes after HI. Estradiol therapy improved behavioral performance in both sexes but did not reverse a deficit in hippocampal volume ipsilateral to the insult. Thus the effects of estradiol do not appear to be via cell death or proliferation but rather involve other components of neural functioning. Published by Elsevier Inc.

Identification of New Orbits to Enable Future Missions for the Exploration of the Martian Moon Phobos

NASA Astrophysics Data System (ADS)

Zamaro, Mattia; Biggs, James D.

One of the paramount stepping stones towards NASA's long-term goal of undertaking human missions to Mars is the exploration of the Martian moons. In this paper, a showcase of various classes of non-Keplerian orbits are identified and a number of potential mission applications in the Mars-Phobos system are proposed. These applications include: low-thrust hovering around Phobos for close-range observations; Libration Point Orbits in enhanced three-body dynamics to enable unique low-cost operations for space missions in the proximity of Phobos; their manifold structure for high-performance landing/take-off maneuvers to and from Phobos' surface; Quasi-Satellite Orbits for long-period station-keeping and maintenance. In particular, these orbits could exploit Phobos' occulting bulk as a passive radiation shield during future manned flights to Mars to reduce human exposure to radiation. Moreover, the latter orbits can be used as an orbital garage, requiring no orbital maintenance, where a spacecraft could make planned pit-stops during a round-trip mission to Mars.

Phenomenology as research method or substantive metaphysics? An overview of phenomenology's uses in nursing.

PubMed

Earle, Vicki

2010-10-01

In exploring phenomenological literature, it is evident that the term 'phenomenology' holds rather different meanings depending upon the context. Phenomenology has been described as both a philosophical movement and an approach to human science research. The phenomenology of Husserl, Heidegger, Gadamer, and Merleau-Ponty was philosophical in nature and not intended to provide rules or procedures for conducting research. The Canadian social scientist, van Manen, however, introduced specific guidelines for conducting human science research, which is rooted in hermeneutic phenomenology and this particular method has been employed in professional disciplines such as education, nursing, clinical psychology, and law. The purpose of this paper is to explore the difference between the phenomenological method as described by van Manen and that of other philosophers such as Husserl, Heidegger, Gadamer, and Merleau-Ponty. In so doing, the author aims to address the blurred boundaries of phenomenology as a research method and as a philosophical movement and highlight the influence of these blurred boundaries on nursing knowledge development.

Volatile Analysis by Pyrolysis of Regolith for Planetary Resource Exploration

NASA Technical Reports Server (NTRS)

Glavin, Daniel P.; Malespin, Charles; ten Kate, Inge L.; Getty, Stephanie A.; Holmes, Vincent E.; Mumm, Erik; Franz, Heather B.; Noreiga, Marvin; Dobson, Nick; Southard, Adrian E.;

Ecosystem health: I. Measuring ecosystem health

NASA Astrophysics Data System (ADS)

Schaeffer, David J.; Herricks, Edwin E.; Kerster, Harold W.

1988-07-01

Ecosystem analysis has been advanced by an improved understanding of how ecosystems are structured and how they function. Ecology has advanced from an emphasis on natural history to consideration of energetics, the relationships and connections between species, hierarchies, and systems theory. Still, we consider ecosystems as entities with a distinctive character and individual characteristics. Ecosystem maintenance and preservation form the objective of impact analysis, hazard evaluation, and other management or regulation activities. In this article we explore an approach to ecosystem analysis which identifies and quantifies factors which define the condition or state of an ecosystem in terms of health criteria. We relate ecosystem health to human/nonhuman animal health and explore the difficulties of defining ecosystem health and suggest criteria which provide a functional definition of state and condition. We suggest that, as has been found in human/nonhuman animal health studies, disease states can be recognized before disease is of clinical magnitude. Example disease states for ecosystems are functionally defined and discussed, together with test systems for their early detection.

Electromagnetic Simulations of Ground-Penetrating Radar Propagation near Lunar Pits and Lava Tubes

NASA Technical Reports Server (NTRS)

Zimmerman, M. I.; Carter, L. M.; Farrell, W. M.; Bleacher, J. E.; Petro, N. E.

2013-01-01

Placing an Orion capsule at the Earth-Moon L2 point (EML2) would potentially enable telerobotic operation of a rover on the lunar surface. The Human Exploration Virtual Institute (HEVI) is proposing that rover operations be carried out near one of the recently discovered lunar pits, which may provide radiation shielding for long duration human stays as well as a cross-disciplinary, science-rich target for nearer-term telerobotic exploration. Ground penetrating radar (GPR) instrumentation included onboard a rover has the potential to reveal many details of underground geologic structures near a pit, as well as characteristics of the pit itself. In the present work we employ the full-wave electromagnetic code MEEP to simulate such GPR reflections from a lunar pit and other subsurface features including lava tubes. These simulations will feed forward to mission concepts requiring knowledge of where to hide from harmful radiation and other environmental hazards such as plama charging and extreme diurnal temperatures.

Emergence of Scale-Free Syntax Networks

NASA Astrophysics Data System (ADS)

Corominas-Murtra, Bernat; Valverde, Sergi; Solé, Ricard V.

The evolution of human language allowed the efficient propagation of nongenetic information, thus creating a new form of evolutionary change. Language development in children offers the opportunity of exploring the emergence of such complex communication system and provides a window to understanding the transition from protolanguage to language. Here we present the first analysis of the emergence of syntax in terms of complex networks. A previously unreported, sharp transition is shown to occur around two years of age from a (pre-syntactic) tree-like structure to a scale-free, small world syntax network. The observed combinatorial patterns provide valuable data to understand the nature of the cognitive processes involved in the acquisition of syntax, introducing a new ingredient to understand the possible biological endowment of human beings which results in the emergence of complex language. We explore this problem by using a minimal, data-driven model that is able to capture several statistical traits, but some key features related to the emergence of syntactic complexity display important divergences.

The International Space Station: Stepping-stone to Exploration

NASA Technical Reports Server (NTRS)

Gerstenmaier, William H.; Kelly, Brian K.; Kelly, Brian K.

2005-01-01

As the Space Shuttle returns to flight this year, major reconfiguration and assembly of the International Space Station continues as the United States and our 5 International Partners resume building and carry on operating this impressive Earth-orbiting research facility. In his January 14, 2004, speech announcing a new vision for America's space program, President Bush ratified the United States' commitment to completing construction of the ISS by 2010. The current ongoing research aboard the Station on the long-term effects of space travel on human physiology will greatly benefit human crews to venture through the vast voids of space for months at a time. The continual operation of ISS leads to new knowledge about the design, development and operation of system and hardware that will be utilized in the development of new deep-space vehicles needed to fulfill the Vision for Exploration. This paper will provide an overview of the ISS Program, including a review of the events of the past year, as well as plans for next year and the future.

Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling

PubMed Central

Kasperkiewicz, Paulina; Poreba, Marcin; Snipas, Scott J.; Parker, Heather; Winterbourn, Christine C.; Salvesen, Guy S.; Drag, Marcin

2014-01-01

The exploration of protease substrate specificity is generally restricted to naturally occurring amino acids, limiting the degree of conformational space that can be surveyed. We substantially enhanced this by incorporating 102 unnatural amino acids to explore the S1–S4 pockets of human neutrophil elastase. This approach provides hybrid natural and unnatural amino acid sequences, and thus we termed it the Hybrid Combinatorial Substrate Library. Library results were validated by the synthesis of individual tetrapeptide substrates, with the optimal substrate demonstrating more than three orders of magnitude higher catalytic efficiency than commonly used substrates of elastase. This optimal substrate was converted to an activity-based probe that demonstrated high selectivity and revealed the specific presence of active elastase during the process of neutrophil extracellular trap formation. We propose that this approach can be successfully used for any type of endopeptidase to deliver high activity and selectivity in substrates and probes. PMID:24550277

International Space Exploration Coordination Group Assessment of Technology Gaps for LOx/Methane Propulsion Systems for the Global Exploration Roadmap

NASA Technical Reports Server (NTRS)

Hurlbert, Eric A.; Whitley, Ryan; Klem, Mark D.; Johnson, Wesley; Alexander, Leslie; D'Aversa, Emanuela; Ruault, Jean-Marc; Manfletti, Chiara; Caruana, Jean-Noel; Ueno, Hiroshi;

The Role of Cis-Lunar Space in Future Global Space Exploration

NASA Technical Reports Server (NTRS)

Bobskill, Marianne R.; Lupisella, Mark L.

2012-01-01

Cis-lunar space offers affordable near-term opportunities to help pave the way for future global human exploration of deep space, acting as a bridge between present missions and future deep space missions. While missions in cis-lunar space have value unto themselves, they can also play an important role in enabling and reducing risk for future human missions to the Moon, Near-Earth Asteroids (NEAs), Mars, and other deep space destinations. The Cis-Lunar Destination Team of NASA's Human Spaceflight Architecture Team (HAT) has been analyzing cis-lunar destination activities and developing notional missions (or "destination Design Reference Missions" [DRMs]) for cis-lunar locations to inform roadmap and architecture development, transportation and destination elements definition, operations, and strategic knowledge gaps. The cis-lunar domain is defined as that area of deep space under the gravitational influence of the earth-moon system. This includes a set of earth-centered orbital locations in low earth orbit (LEO), geosynchronous earth orbit (GEO), highly elliptical and high earth orbits (HEO), earth-moon libration or "Lagrange" points (E-ML1 through E-ML5, and in particular, E-ML1 and E-ML2), and low lunar orbit (LLO). To help explore this large possibility space, we developed a set of high level cis-lunar mission concepts in the form of a large mission tree, defined primarily by mission duration, pre-deployment, type of mission, and location. The mission tree has provided an overall analytical context and has helped in developing more detailed design reference missions that are then intended to inform capabilities, operations, and architectures. With the mission tree as context, we will describe two destination DRMs to LEO and GEO, based on present human space exploration architectural considerations, as well as our recent work on defining mission activities that could be conducted with an EML1 or EML2 facility, the latter of which will be an emphasis of this paper, motivated in part by recent interest expressed at the Global Exploration Roadmap Stakeholder meeting. This paper will also explore the links between this HAT Cis-Lunar Destination Team analysis and the recently released ISECG Global Exploration Roadmap and other potential international considerations, such as preventing harmful interference to radio astronomy observations in the shielded zone of the moon.

The effects of acute social isolation on long-term social recognition memory.

PubMed

Leser, Noam; Wagner, Shlomo

2015-10-01

The abilities to recognize individual animals of the same species and to distinguish them from other individuals are the basis for all mammalian social organizations and relationships. These abilities, termed social recognition memory, can be explored in mice and rats using their innate tendency to investigate novel social stimuli more persistently than familiar ones. Using this methodology it was found that social recognition memory is mediated by a specific neural network in the brain, the activity of which is modulated by several molecules, such the neuropeptides oxytocin and vasopressin. During the last 15 years several independent studies have revealed that social recognition memory of mice and rats depends upon their housing conditions. Specifically, long-term social recognition memory cannot be formed as shortly as few days following social isolation of the animal. This rapid and reversible impairment caused by acute social isolation seems to be specific to social memory and has not been observed in other types of memory. Here we review these studies and suggest that this unique system may serve for exploring of the mechanisms underlying the well-known negative effects of partial or perceived social isolation on human mental health. Copyright © 2015 Elsevier Inc. All rights reserved.

Metaphors to Drive By: Exploring New Ways to Guide Human-Robot Interaction

DOE Office of Scientific and Technical Information (OSTI.GOV)

David J. Bruemmer; David I. Gertman; Curtis W. Nielsen

2007-08-01

Autonomous behaviors created by the research and development community are not being extensively utilized within energy, defense, security, or industrial contexts. This paper provides evidence that the interaction methods used alongside these behaviors may not provide a mental model that can be easily adopted or used by operators. Although autonomy has the potential to reduce overall workload, the use of robot behaviors often increased the complexity of the underlying interaction metaphor. This paper reports our development of new metaphors that support increased robot complexity without passing the complexity of the interaction onto the operator. Furthermore, we illustrate how recognition ofmore » problems in human-robot interactions can drive the creation of new metaphors for design and how human factors lessons in usability, human performance, and our social contract with technology have the potential for enormous payoff in terms of establishing effective, user-friendly robot systems when appropriate metaphors are used.« less

Aggregated responses of human mobility to severe winter storms: An empirical study.

PubMed

Wang, Yan; Wang, Qi; Taylor, John E

2017-01-01

Increasing frequency of extreme winter storms has resulted in costly damages and a disruptive impact on the northeastern United States. It is important to understand human mobility patterns during such storms for disaster preparation and relief operations. We investigated the effects of severe winter storms on human mobility during a 2015 blizzard using 2.69 million Twitter geolocations. We found that displacements of different trip distances and radii of gyration of individuals' mobility were perturbed significantly. We further explored the characteristics of perturbed mobility during the storm, and demonstrated that individuals' recurrent mobility does not have a higher degree of similarity with their perturbed mobility, when comparing with its similarity to non-perturbed mobility. These empirical findings on human mobility impacted by severe winter storms have potential long-term implications on emergency response planning and the development of strategies to improve resilience in severe winter storms.

Overview of Intelligent Power Controller Development for Human Deep Space Exploration

NASA Technical Reports Server (NTRS)

Soeder, James F.; Dever, Timothy P.; McNelis, Anne M.; Beach, Raymond F.; Trase, Larry M.; May, Ryan D.

2014-01-01

Intelligent or autonomous control of an entire spacecraft is a major technology that must be developed to enable NASA to meet its human exploration goals. NASA's current long term human space platform, the International Space Station, is in low Earth orbit with almost continuous communication with the ground based mission control. This permits the near real-time control by the ground of all of the core systems including power. As NASA moves beyond low Earth orbit, the issues of communication time-lag and lack of communication bandwidth beyond geosynchronous orbit does not permit this type of operation. This paper presents the work currently ongoing at NASA to develop an architecture for an autonomous power control system as well as the effort to assemble that controller into the framework of the vehicle mission manager and other subsystem controllers to enable autonomous control of the complete spacecraft. Due to the common problems faced in both space power systems and terrestrial power system, the potential for spin-off applications of this technology for use in micro-grids located at the edge or user end of terrestrial power grids for peak power accommodation and reliability are described.

Overview of Intelligent Power Controller Development for Human Deep Space Exploration

NASA Technical Reports Server (NTRS)

Soeder, James F.; Dever, Timothy P.; McNelis, Anne M.; Beach, Raymond F.; Trase, Larry M.; May, Ryan D.

2014-01-01

Intelligent or autonomous control of an entire spacecraft is a major technology that must be developed to enable NASA to meet its human exploration goals. NASA's current long term human space platform, the International Space Station, is in low earth orbit with almost continuous communication with the ground based mission control. This permits the near real-time control by the ground of all of the core systems including power. As NASA moves beyond Low Earth Orbit, the issues of communication time-lag and lack of communication bandwidth beyond geosynchronous orbit does not permit this type of operation. This paper presents the work currently ongoing at NASA to develop an architecture for an autonomous power control system as well as the effort to assemble that controller into the framework of the vehicle mission manager and other subsystem controllers to enable autonomous control of the complete spacecraft. Due to the common problems faced in both space power systems and terrestrial power system, the potential for spin-off applications of this technology for use in micro-grids located at the edge or user end of terrestrial power grids for peak power accommodation and reliability are described.

Applied Operations Research: Augmented Reality in an Industrial Environment

NASA Technical Reports Server (NTRS)

Cole, Stuart K.

2015-01-01

Augmented reality is the application of computer generated data or graphics onto a real world view. Its use provides the operator additional information or a heightened situational awareness. While advancements have been made in automation and diagnostics of high value critical equipment to improve readiness, reliability and maintenance, the need for assisting and support to Operations and Maintenance staff persists. AR can improve the human machine interface where computer capabilities maximize the human experience and analysis capabilities. NASA operates multiple facilities with complex ground based HVCE in support of national aerodynamics and space exploration, and the need exists to improve operational support and close a gap related to capability sustainment where key and experienced staff consistently rotate work assignments and reach their expiration of term of service. The initiation of an AR capability to augment and improve human abilities and training experience in the industrial environment requires planning and establishment of a goal and objectives for the systems and specific applications. This paper explored use of AR in support of Operation staff in real time operation of HVCE and its maintenance. The results identified include identification of specific goal and objectives, challenges related to availability and computer system infrastructure.

Overview of Intelligent Power Controller Development for Human Deep Space Exploration

NASA Technical Reports Server (NTRS)

Soeder, James F.; Dever, Timothy P.; McNelis, Anne M.; Beach, Raymond F.; Trase, Larry M.; May, Ryan

2014-01-01

Intelligent or autonomous control of an entire spacecraft is a major technology that must be developed to enable NASA to meet its human exploration goals. NASAs current long term human space platform, the International Space Station, is in low earth orbit with almost continuous communication with the ground based mission control. This permits the near real-time control by the ground of all of the core systems including power. As NASA moves beyond Low Earth Orbit, the issues of communication time-lag and lack of communication bandwidth beyond geosynchronous orbit does not permit this type of operation. This paper presents the work currently ongoing at NASA to develop an architecture for an autonomous power control system as well as the effort to assemble that controller into the framework of the vehicle mission manager and other subsystem controllers to enable autonomous control of the complete spacecraft. Due to the common problems faced in both space power systems and terrestrial power system, the potential for spin-off applications of this technology for use in micro-grids located at the edge or user end of terrestrial power grids for peak power accommodation and reliability are described.

Ecological consequences of body size decline in harvested fish species: positive feedback loops in trophic interactions amplify human impact.

PubMed

Audzijonyte, Asta; Kuparinen, Anna; Gorton, Rebecca; Fulton, Elizabeth A

2013-04-23

Humans are changing marine ecosystems worldwide, both directly through fishing and indirectly through climate change. One of the little explored outcomes of human-induced change involves the decreasing body sizes of fishes. We use a marine ecosystem model to explore how a slow (less than 0.1% per year) decrease in the length of five harvested species could affect species interactions, biomasses and yields. We find that even small decreases in fish sizes are amplified by positive feedback loops in the ecosystem and can lead to major changes in natural mortality. For some species, a total of 4 per cent decrease in length-at-age over 50 years resulted in 50 per cent increase in predation mortality. However, the magnitude and direction in predation mortality changes differed among species and one shrinking species even experienced reduced predation pressure. Nevertheless, 50 years of gradual decrease in body size resulted in 1-35% decrease in biomasses and catches of all shrinking species. Therefore, fisheries management practices that ignore contemporary life-history changes are likely to overestimate long-term yields and can lead to overfishing.

Strategic Studies Quarterly: Volume 10, No. 4 Winter 2016

DTIC Science & Technology

2016-01-01

capabilities for intelligence col- lection, communications , and missile warning-capabilities largely in- tended to support strategic nuclear forces. 1...WINTER 2016 NASA in the Second Space Age: Exploration, Partnering, and Security declined by 12 percent in real terms from FYlO to FY15. 11 The BCA...orbit as part of the Apollo program, six of which landed on the moon, while there have been hun- dreds of manned missions to LEO. The risks to humans

Exploration Roadmap Working Group (ERWG) Data Collection, NASA's Inputs

NASA Technical Reports Server (NTRS)

Drake, Bret; Landis, Rob; Thomas, Andrew; Mauzy, Susan; Graham, Lee; Culbert, Chris; Troutman, Pat

2010-01-01

This slide presentation reviews four areas for further space exploration: (1) Human Exploration of Mars Design Reference Architecture (DRA) 5.0, (2) Robotic Precursors targeting Near Earth Objects (NEO) for Human Exploration, (3) Notional Human Exploration of Near Earth Objects and (4) Low Earth Orbit (LEO) Refueling to Augment Human Exploration. The first presentation reviews the goals and objectives of the Mars DRA, presents a possible mission profile, innovation requirements for the mission and key risks and challenges for human exploration of Mars. The second presentation reviews the objective and goals of the robotic precursors to the NEO and the mission profile of such robotic exploration. The third presentation reviews the mission scenario of human exploration of NEO, the objectives and goals, the mission operational drivers, the key technology needs and a mission profile. The fourth and last presentation reviews the examples of possible refueling in low earth orbit prior to lunar orbit insertion, to allow for larger delivered payloads for a lunar mission.

On interviewing people with pets: reflections from qualitative research on people with long-term conditions.

PubMed

Ryan, Sara; Ziebland, Sue

2015-01-01

There is mounting evidence that pets are associated with physiological, psychological and social benefits for humans. Much of this research has come from western countries, where there have been consistent calls for greater engagement with pet ownership and health. Drawing on a secondary analysis of 61 in-depth interviews with people, or carers of people, with long-term conditions, we explore how pets feature in people's narrative accounts of their experiences. Our findings demonstrate the multifaceted nature of people's relationships with pets, and the embedded and embodied ways in which human-nonhuman interactions are played out in narratives of chronic illness. Our study differs from other work on pets and health in that, by returning to the interview video recordings, we were able to explore the sometimes three-way interactions, the co(a)gency, between participants, pets and researchers. Pets were often presented as important family members, yet the researchers' responses to the presence or talk about pets was often markedly different from their reactions to other household members. We conclude with cautioning against the downgrading of pets in narrative health research. Narrative approaches may invite participants to talk about what is important to them, yet they clearly have limitations in practice. © 2015 The Authors. Sociology of Health & Illness © 2015 Foundation for the Sociology of Health & Illness/John Wiley & Sons Ltd.

Developing Crew Health Care and Habitability Systems for the Exploration Vision

NASA Technical Reports Server (NTRS)

Laurini, Kathy; Sawin, Charles F.

2006-01-01

This paper will discuss the specific mission architectures associated with the NASA Exploration Vision and review the challenges and drivers associated with developing crew health care and habitability systems to manage human system risks. Crew health care systems must be provided to manage crew health within acceptable limits, as well as respond to medical contingencies that may occur during exploration missions. Habitability systems must enable crew performance for the tasks necessary to support the missions. During the summer of 2005, NASA defined its exploration architecture including blueprints for missions to the moon and to Mars. These mission architectures require research and technology development to focus on the operational risks associated with each mission, as well as the risks to long term astronaut health. This paper will review the highest priority risks associated with the various missions and discuss NASA s strategies and plans for performing the research and technology development necessary to manage the risks to acceptable levels.

Introduction to Japanese exploration study to the moon

NASA Astrophysics Data System (ADS)

Hashimoto, T.; Hoshino, T.; Tanaka, S.; Otake, H.; Otsuki, M.; Wakabayashi, S.; Morimoto, H.; Masuda, K.

2014-11-01

The Japan Aerospace Exploration Agency (JAXA) views the lunar lander SELENE-2 as the successor to the SELENE mission. In this presentation, the mission objectives of SELENE-2 are shown together with the present design status of the spacecraft. JAXA launched the Kaguya (SELENE) lunar orbiter in September 2007, and the spacecraft observed the Moon and a couple of small satellites using 15 instruments. As the next step in lunar exploration, the lunar lander SELENE-2 is being considered. SELENE-2 will land on the lunar surface and perform in-situ scientific observations, environmental investigations, and research for future lunar utilization including human activity. At the same time, it will demonstrate key technologies for lunar and planetary exploration such as precise and safe landing, surface mobility, and overnight survival. The lander will carry laser altimeters, image sensors, and landing radars for precise and safe landing. Landing legs and a precisely controlled propulsion system will also be developed. A rover is being designed to be able to travel over a wide area and observe featured terrain using scientific instruments. Since some of the instruments require long-term observation on the lunar surface, technology for night survival over more than 2 weeks needs to be considered. The SELENE-2 technologies are expected to be one of the stepping stones towards future Japanese human activities on the moon and to expand the possibilities for deep space science.

Building Operations Efficiencies into NASA's Ares I Crew Launch Vehicle Design

NASA Technical Reports Server (NTRS)

Dumbacher, Daniel

2006-01-01

The U.S. Vision for Space Exploration guides the National Aeronautics and Space Administration s (NASA's) challenging missions that expand humanity s boundaries and open new routes to the space frontier. With the Agency's commitment to complete the International Space Station (ISS) and to retire the venerable Space Shuttle by 2010, the NASA Administrator commissioned the Exploration Systems Architecture Study (ESAS) in mid 2005 to analyze options for safe, simple, cost-efficient launch solutions that could deliver human-rated space transportation capabilities in a timely manner within fixed budget guidelines. The Exploration Launch Projects Office, chartered in October 2005, has been conducting systems engineering studies and business planning over the past few months to successively refine the design configurations and better align vehicle concepts with customer and stakeholder requirements, such as significantly reduced life-cycle costs. As the Agency begins the process of replacing the Shuttle with a new generation of spacecraft destined for missions beyond low-Earth orbit to the Moon and Mars, NASA is designing the follow-on crew and cargo launch systems for maximum operational efficiencies. To sustain the long-term exploration of space, it is imperative to reduce the $4.5 billion NASA typically spends on space transportation each year. This paper gives top-level information about how the follow-on Ares I Crew Launch Vehicle (CLV) is being designed for improved safety and reliability, coupled with reduced operations costs.

The Centre for Early Human Behaviour (EHB) at the University of Bergen: A transdisciplinary exploration into the evolution of homo sapiens behaviour

NASA Astrophysics Data System (ADS)

Sobolowski, Stefan; Henshilwood, Christopher; Jansen, Eystein

2017-04-01

Homo sapiens was anatomically modern by 200 000 years ago in Africa, but there is no archaeological evidence to demonstrate that behaviour was modern at the time. Attributes of modern behaviour, perhaps inspired by changes in the human brain, are only recognizable after 100 000 years ago. Before we can study the process, we must critically define the criteria for the term 'modern behaviour' and then find a means to recognize such behavior in the record. This seemingly simple research statement involves complex exploration by a team of specialists. In this highly competitive research field our centre will, for the first time, be able to rise to the challenge by combining the skills of cutting-edge scientists in archaeology, climate reconstruction and modelling, and the cognitive and social sciences. Over the next decade we will integrate knowledge and methods from different disciplines to synthesize approaches and contribute to a sophisticated understanding of early human behaviour. Our highly ambitious research program will focus explicitly on rare, well preserved archaeological sites occupied in the period between 100-50 000 years ago because these contain the 'keys' for unlocking the past. A major competitive edge is the EHB Director's 25 years of archaeological experience and his long-term exclusive access, with permits, to a number of the best-preserved sites in the southern Cape, South Africa - a region regarded as a major locus for vital evidence that could inform on the behaviour of early humans. Our planned excavations at existing and new sites and our ground-breaking and innovative interdisciplinary approaches, including climate (The Bjerknes Centre for Climate Research) and cognitive research, to understanding the processes that shaped human cultures. Primarily, EHB will directly address unanswered, first order questions about Homo sapiens: a) what defines the switch to 'modern behaviour', exactly how should this term be defined and then, when, why and how did the 'switch' occur; b) were there changes in the human brain at that time that accelerated behavioural variability and how can these be measured now? Secondary linked tasks address the social organization of these early humans: was social cohesion enhanced by symbolic material culture or vice-versa and did it lead to innovation; what cognitive skills had to be in place in order for other skills to develop; how adaptable were humans to environmental change and did climate act as a driver for technological innovation, social change and subsistence adaptations? This presentation will introduce the recently awarded center, its key objectives and ambitions, and serve as an open invitation to collaboration and intellectual engagement on this exciting topic.

A possible connection between thermal comfort and health

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stoops, John L.

It is a well-established fact that cardiovascular health requires periodic exercise during which the human body often experiences significant physical discomfort. It is not obvious to the exerciser that the short-term pain and discomfort has a long-term positive health impact. Many cultures have well-established practices that involve exposing the body to periodic thermal discomfort. Scandinavian saunas and American Indian sweat lodges are two examples. Both are believed to promote health and well-being. Vacations often intentionally include significant thermal discomfort as part of the experience (e.g., sunbathing, and downhill skiing). So people often intentionally make themselves thermally uncomfortable yet the entiremore » foundation of providing the thermal environment in our buildings is done to minimize the percentage of people thermally dissatisfied. We must provide an environment that does not negatively impact short-term health and we need to consider productivity but are our current thermal comfort standards too narrowly defined and do these standards actually contribute to longer-term negative health impacts? This paper examines the possibility that the human body thermoregulatory system has a corollary relationship to the cardiovascular system. It explores the possibility that we have an inherent need to exercise our thermoregulatory system. Potential, physiological, sociological and energy ramifications of these possibilities are discussed.« less

Short Term Gains, Long Term Pains: How Cues About State Aid Learning in Dynamic Environments

PubMed Central

Gureckis, Todd M.; Love, Bradley C.

2009-01-01

Successful investors seeking returns, animals foraging for food, and pilots controlling aircraft all must take into account how their current decisions will impact their future standing. One challenge facing decision makers is that options that appear attractive in the short-term may not turn out best in the long run. In this paper, we explore human learning in a dynamic decision-making task which places short- and long-term rewards in conflict. Our goal in these studies was to evaluate how people’s mental representation of a task affects their ability to discover an optimal decision strategy. We find that perceptual cues that readily align with the underlying state of the task environment help people overcome the impulsive appeal of short-term rewards. Our experimental manipulations, predictions, and analyses are motivated by current work in reinforcement learning which details how learners value delayed outcomes in sequential tasks and the importance that “state” identification plays in effective learning. PMID:19427635

ISRU in the Context of Future European Human Mars Exploration

NASA Astrophysics Data System (ADS)

Baker, A. M.; Tomatis, C.

2002-01-01

ISRU or In-Situ Resource Utilisation is the use of Martian resources to manufacture, typically, life support consumables (e.g. water, oxygen, breathing buffer gases), and propellant for a return journey to Earth. European studies have shown that some 4kg of reaction mass must be launched to LEO to send 1kg payload to Mars orbit, with landing on the Mars surface reducing payload mass still further. This results in very high transportation costs to Mars, and still higher costs for returning payloads to Earth. There is therefore a major incentive to reduce payload mass for any form of Mars return mission (human or otherwise) by generating consumables on the surface. ESA through its GSTP programme has been investigating the system level design of a number of mission elements as potential European contributions to an international human Mars exploration mission intended for the 2020-2030 timeframe. One of these is an ISRU plant, a small chemical factory to convert feedstock brought from Earth (hydrogen), and Martian atmospheric gases (CO2 and trace quantities of nitrogen and argon) into methane and oxygen propellant for Earth return and life support consumables, in advance of the arrival of astronauts. ISRU technology has been the subject of much investigation around the world, but little detailed research or system level studies have been reported in Europe. Furthermore, the potential applicability of European expertise, technology and sub- system studies to Martian ISRU is not well quantified. Study work covered in this paper has compared existing designs (e.g. NASA's Design Reference Mission, DLR and Mars Society studies) with the latest ESA derived requirements for human Mars exploration, and has generated a system level ISRU design. This paper will review and quantify the baseline chemical reactions essential for ISRU, including CO2 collection and purification, Sabatier reduction of CO2 with hydrogen to methane and water, and electrolysis of water in the context of the latest requirements. In addition, the paper will explore the options for compressing, cooling and storing gaseous products, methods for extracting buffer gases (such as nitrogen), and chemistries for producing additional oxygen. The paper will be written from the viewpoint of what European industry might be able to offer to a future set of Martian ISRU requirements, but in the context of an international human Mars mission. For example, the development of a compact Sabatier reactor for ISS air revitalisation, and high temperature methane cracking reactors by Astrium GmbH are considered. Other, current research has highlighted low temperature catalytic decomposition of methane, under evaluation as means of producing carbon nanofibres; and the photocatalytic reduction of CO2 as relevant technologies. This paper will also consider some key issues in ISRU design which have not yet been widely addressed, including the suitability of an Ar/N2 buffer gas mixture for life support (and the difficulties of its separation from the Martian atmosphere), the transfer of hydrogen feedstock to Mars, the storage of products on the surface, and the thermal balance in an ISRU plant (e.g. the balance of energy required for liquefaction of oxygen, against the heat sink available from the liquid hydrogen feedstock). In addition, this paper will detail the selected reaction chemistries for each required subsystem, giving (where possible) mass, power and volume estimates. These will be drawn together, justified and presented as a system level design for an ISRU plant. Finally, a technology roadmap for ISRU development will be covered, suggesting near term (2002-2006), medium term (2006-2015) and long term (2015-2030) priorities which could enable a European ISRU capability to be qualified for initial human Mars exploration.

NASA Exploration Forum: Human Path to Mars

NASA Image and Video Library

2014-04-29

William Gerstenmaier, NASA Associate Administrator for Human Exploration and Operations, speaks during an Exploration Forum showcasing NASA's human exploration path to Mars in the James E. Webb Auditorium at NASA Headquarters on Tuesday, April 29, 2014. Photo Credit: (NASA/Joel Kowsky)

77 FR 66082 - NASA Advisory Council; Human Exploration and Operations Committee; Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-01

... Exploration and Operations Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION... Integration --International Space Station Status --Outreach --Human Exploration and Operations Status... Advisory Council Human Exploration and Operations Committee session in the Space Operations Center, Room...

Human Research Program Opportunities

NASA Technical Reports Server (NTRS)

Kundrot, Craig E.

2014-01-01

The goal of HRP is to provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration. The Human Research Program was designed to meet the needs of human space exploration, and understand and reduce the risk to crew health and performance in exploration missions.

Human Challenges in Exploration Missions

NASA Technical Reports Server (NTRS)

Lloyd, Charles W.

2007-01-01

This viewgraph presents an overview using pictures some of the history of human exploration of the new frontiers of Earth and then examines some of the challenges to human exploration of space. Particular attention is given to the environmental factors and to the social and human factors that effect humans in space environments.

Unraveling the metabolic health benefits of fasting related to religious beliefs: A narrative review.

PubMed

Persynaki, Angeliki; Karras, Spyridon; Pichard, Claude

2017-03-01

Periodic fasting, under a religious aspect, has been adopted by humans for centuries as a crucial pathway of spiritual purification. Caloric restriction, with or without exclusion of certain types of food, is often a key component. Fasting varies significantly among different populations according to cultural habits and local climate conditions. Religious fasting in terms of patterns (continuous versus intermittent) and duration can vary from 1 to 200 d; thus, the positive and negative impact on health can be considerable. Advantages of religious fasting are claimed by many but have been explored mainly by a limited number of studies conducted in Buddhist, Christian, or Muslim populations. These trials indicate that religious fasting has beneficial effects on body weight and glycemia, cardiometabolic risk markers, and oxidative stress parameters. Animals exposed to a diet mimicking fasting have demonstrated weight loss as well as lowered plasma levels of glucose, triacylglycerols, and insulin growth factor-1, although lean body mass remained stable. Diabetic mice on repeated intermittent fasting had less insulin resistance that mice fed ad libitum. The long-term significance of such changes on global health remains to be explored. This review summarizes the data available with regard to benefits of fasting followed for religious reasons on human health, body anthropometry, and cardio-metabolic risk markers; aims to bridge the current knowledge gap on available evidence and suggests considerations for the future research agenda. Future studies should explore every type of religious fasting, as well as their consequences in subpopulations such as children, pregnant women, and the elderly, or patients with chronic metabolic diseases. Copyright © 2016 Elsevier Inc. All rights reserved.

Xenon Acquisition Strategies for High-Power Electric Propulsion NASA Missions

NASA Technical Reports Server (NTRS)

Herman, Daniel A.; Unfried, Kenneth G.

2015-01-01

Solar electric propulsion (SEP) has been used for station-keeping of geostationary communications satellites since the 1980s. Solar electric propulsion has also benefitted from success on NASA Science Missions such as Deep Space One and Dawn. The xenon propellant loads for these applications have been in the 100s of kilograms range. Recent studies performed for NASA's Human Exploration and Operations Mission Directorate (HEOMD) have demonstrated that SEP is critically enabling for both near-term and future exploration architectures. The high payoff for both human and science exploration missions and technology investment from NASA's Space Technology Mission Directorate (STMD) are providing the necessary convergence and impetus for a 30-kilowatt-class SEP mission. Multiple 30-50- kilowatt Solar Electric Propulsion Technology Demonstration Mission (SEP TDM) concepts have been developed based on the maturing electric propulsion and solar array technologies by STMD with recent efforts focusing on an Asteroid Redirect Robotic Mission (ARRM). Xenon is the optimal propellant for the existing state-of-the-art electric propulsion systems considering efficiency, storability, and contamination potential. NASA mission concepts developed and those proposed by contracted efforts for the 30-kilowatt-class demonstration have a range of xenon propellant loads from 100s of kilograms up to 10,000 kilograms. This paper examines the status of the xenon industry worldwide, including historical xenon supply and pricing. The paper will provide updated information on the xenon market relative to previous papers that discussed xenon production relative to NASA mission needs. The paper will discuss the various approaches for acquiring on the order of 10 metric tons of xenon propellant to support potential near-term NASA missions. Finally, the paper will discuss acquisitions strategies for larger NASA missions requiring 100s of metric tons of xenon will be discussed.

Humans' Relationship to Flowers as an Example of the Multiple Components of Embodied Aesthetics.

PubMed

Huss, Ephrat; Bar Yosef, Kfir; Zaccai, Michele

2018-03-01

This paper phenomenologically and qualitatively explores the relationship between humans and flowers as a relationship that throws light on the synergetic dynamics of embodied aesthetics. Its methods include qualitative description and thematic analyses of preferred flower types, as well as concept maps of the general term 'flower' by 120 students in Israel. The results revealed the interactive perceptual-compositional elements, as well as embodied, relational, and socially embedded elements of the aesthetic pleasure associated with flowers. Implications of this case study are generalized to understand the multiple and interactive components of embodied aesthetic experiences as a deep source of pleasure through interactive stimulation by and connection to the natural world.

Developing Fabrication Technologies to Provide On Demand Manufacturing for Exploration of the Moon and Mars

NASA Technical Reports Server (NTRS)

Hammond, Monica S.; Good, James E.; Gilley, Scott D.; Howard, Richard W.

2006-01-01

NASA's human exploration initiative poses great opportunity and risk for manned and robotic missions to the Moon, Mars, and beyond. Engineers and scientists at the Marshall Space Flight Center (MSFC) are developing technologies for in situ fabrication capabilities during lunar and Martian surface operations utilizing provisioned and locally refined materials. Current fabrication technologies must be advanced to support the special demands and applications of the space exploration initiative such as power, weight and volume constraints. In Situ Fabrication and Repair (ISFR) will advance state-of-the-art technologies in support of habitat structure development, tools, and mechanical part fabrication. The repair and replacement of space mission components, such as life support items or crew exercise equipment, fall within the ISFR scope. This paper will address current fabrication technologies relative to meeting ISFR targeted capabilities, near-term advancement goals, and systematic evaluation of various fabrication methods.

Mars Surface Systems Common Capabilities and Challenges for Human Missions

NASA Technical Reports Server (NTRS)

Toups, Larry; Hoffman, Stephen J.

2016-01-01

This paper describes the current status of common systems and operations as they are applied to actual locations on Mars that are representative of Exploration Zones (EZ) - NASA's term for candidate locations where humans could land, live and work on the Martian surface. Given NASA's current concepts for human missions to Mars, an EZ is a collection of Regions of Interest (ROIs) located within approximately 100 kilometers of a centralized landing site. ROIs are areas that are relevant for scientific investigation and/or development/maturation of capabilities and resources necessary for a sustainable human presence. An EZ also contains a habitation site that will be used by multiple human crews during missions to explore and utilize the ROIs within the EZ. The Evolvable Mars Campaign (EMC), a description of NASA's current approach to these human Mars missions, assumes that a single EZ will be identified within which NASA will establish a substantial and durable surface infrastructure that will be used by multiple human crews. The process of identifying and eventually selecting this single EZ will likely take many years to finalized. Because of this extended EZ selection process it becomes important to evaluate the current suite of surface systems and operations being evaluated for the EMC as they are likely to perform at a variety of proposed EZ locations and for the types of operations - both scientific and development - that are proposed for these candidate EZs. It is also important to evaluate proposed EZs for their suitability to be explored or developed given the range of capabilities and constraints for the types of surface systems and operations being considered within the EMC. Four locations identified in the Mars Exploration Program Analysis Group (MEPAG)'s Human Exploration of Mars Science Analysis Group (HEM-SAG) report are used in this paper as representative of candidate EZs that will emerge from the selection process that NASA has initiated. A field station site plan is developed for each of these four HEM-SAG sites. Because of the difficulty in getting equipment and supplies to the surface of Mars, specific assessments have been conducted to identify those systems and processes that can perform in multiple, sometimes completely unrelated, situations. Examples of common systems that are assessed at all of these sites include: (a) habitation and associated logistics storage systems, (b) a centralized power plant capable of supplying power to a geographically distributed (but within the central habitation zone) set of systems, (c) mobility systems that can be used to off-load and move payloads to specific locations at the central field station location that could also be used to traverse long distances to reach some of the more remote ROIs and (d) robotic systems that can support various activities (such as system set up and maintenance) at the field station that could also be used to explore scientific ROIs and used to support site-specific ISRU (In Situ Resource Utilization) production activities.

NASA's In-Space Manufacturing Project: Development of a Multimaterial, Multiprocess Fabrication Laboratory for the International Space Station

NASA Technical Reports Server (NTRS)

Prater, T.; Werkheiser, N.; Bean, Q.; Ledbetter, F.; Soohoo, H.; Wilkerson, M.; Hipp, B.

2017-01-01

NASA's long term goal is to send humans to Mars. Over the next two decades, NASA will work with private industry to develop and demonstrate the technologies and capabilities needed to support exploration of the red planet by humans and ensure their safe return to earth. To accomplish this goal, NASA is employing a capability driven approach to its human spaceflight strategy. This approach will develop a suite of evolving capabilities which provide specific functions to solve exploration challenges. One challenge that is critical to sustainable and safer exploration is the ability to manufacture and recycle materials in space. This paper provides an overview of NASA's in-space manufacturing project, its past and current activities, and how technologies under development will ultimately culminate in a multimaterial, multiprocess fabrication laboratory ('FabLab') to be deployed on the International Space Station in the early 2020s. ISM is a critical capability for the long endurance missions NASA seeks to undertake in the coming decades. An unanticipated failure that can be adapted for in low earth orbit may result in a loss of mission in transit to Mars. In order to have a suite of functional ISM capabilities that are compatible with NASA's exploration timeline, ISM must be equipped with the resources necessary to develop these technologies and deploy them for testing prior to the scheduled de-orbit of ISS in 2024. The paper will discuss the phased approach to FabLab development, desired capabilities, and requirements for the hardware. The FabLab will move NASA and private industry significantly closer to changing historical paradigms for human spaceflight where all materials used in space are launched from earth. While the FabLab will be tested on ISS, the system is ultimately intended for use in a deep space habitat or transit vehicle.

NEEMO 14: Evaluation of Human Performance for Rover, Cargo Lander, Crew Lander, and Exploration Tasks in Simulated Partial Gravity

NASA Technical Reports Server (NTRS)

Chappell, Steven P.; Abercromby, Andrew F.; Gernhardt, Michael L.

2011-01-01

The ultimate success of future human space exploration missions is dependent on the ability to perform extravehicular activity (EVA) tasks effectively, efficiently, and safely, whether those tasks represent a nominal mode of operation or a contingency capability. To optimize EVA systems for the best human performance, it is critical to study the effects of varying key factors such as suit center of gravity (CG), suit mass, and gravity level. During the 2-week NASA Extreme Environment Mission Operations (NEEMO) 14 mission, four crewmembers performed a series of EVA tasks under different simulated EVA suit configurations and used full-scale mockups of a Space Exploration Vehicle (SEV) rover and lander. NEEMO is an underwater spaceflight analog that allows a true mission-like operational environment and uses buoyancy effects and added weight to simulate different gravity levels. Quantitative and qualitative data collected during NEEMO 14, as well as from spacesuit tests in parabolic flight and with overhead suspension, are being used to directly inform ongoing hardware and operations concept development of the SEV, exploration EVA systems, and future EVA suits. OBJECTIVE: To compare human performance across different weight and CG configurations. METHODS: Four subjects were weighed out to simulate reduced gravity and wore either a specially designed rig to allow adjustment of CG or a PLSS mockup. Subjects completed tasks including level ambulation, incline/decline ambulation, standing from the kneeling and prone position, picking up objects, shoveling, ladder climbing, incapacitated crewmember handling, and small and large payload transfer. Subjective compensation, exertion, task acceptability, and duration data as well as photo and video were collected. RESULTS: There appear to be interactions between CG, weight, and task. CGs nearest the subject s natural CG are the most predictable in terms of acceptable performance across tasks. Future research should focus on understanding the interactions between CG, mass, and subject differences.

Common ecology quantifies human insurgency.

PubMed

Bohorquez, Juan Camilo; Gourley, Sean; Dixon, Alexander R; Spagat, Michael; Johnson, Neil F

2009-12-17

Many collective human activities, including violence, have been shown to exhibit universal patterns. The size distributions of casualties both in whole wars from 1816 to 1980 and terrorist attacks have separately been shown to follow approximate power-law distributions. However, the possibility of universal patterns ranging across wars in the size distribution or timing of within-conflict events has barely been explored. Here we show that the sizes and timing of violent events within different insurgent conflicts exhibit remarkable similarities. We propose a unified model of human insurgency that reproduces these commonalities, and explains conflict-specific variations quantitatively in terms of underlying rules of engagement. Our model treats each insurgent population as an ecology of dynamically evolving, self-organized groups following common decision-making processes. Our model is consistent with several recent hypotheses about modern insurgency, is robust to many generalizations, and establishes a quantitative connection between human insurgency, global terrorism and ecology. Its similarity to financial market models provides a surprising link between violent and non-violent forms of human behaviour.

Development and Demonstration of Sustainable Surface Infrastructure for Moon/Mars Exploration

NASA Technical Reports Server (NTRS)

Sanders, Gerald B.; Larson, William E.; Picard, Martin

2011-01-01

For long-term human exploration of the Moon and Mars to be practical, affordable, and sustainable, future missions must be able to identify and utilize resources at the site of exploration. The ability to characterize, extract, processes, and separate products from local material, known as In-Situ Resource Utilization (ISRU), can provide significant reductions in launch mass, logistics, and development costs while reducing risk through increased mission flexibility and protection as well as increased mission capabilities in the areas of power and transportation. Making mission critical consumables like propellants, fuel cell reagents and life support gases, as well as in-situ crew/hardware protection and energy storage capabilities can significantly enhance robotic and human science and exploration missions, however other mission systems need to be designed to interface with and utilize these in-situ developed products and services from the start or the benefits will be minimized or eliminated. This requires a level of surface and transportation system development coordination not typically utilized during early technology and system development activities. An approach being utilized by the US National Aeronautics and Space Administration and the Canadian Space Agency has been to utilize joint analogue field demonstrations to focus technology development activities to demonstrate and integrate new and potentially game changing. mission critical capabilities that would enable an affordable and sustainable surface infrastructure for lunar and Mars robotic and human exploration. Two analogue field tests performed in November 2008 and February 2010 demonstrated first generation capabilities for lunar resource prospecting, exploration site preparation, and oxygen extraction from regolith while initiating integration with mobility, science, fuel cell power, and propulsion disciplines. A third analogue field test currently planned for June 2012 will continue and expand the fidelity and integration of these surface exploration and infrastructure capabilities while adding Mars exploration technologies, improving remote operations and control of hardware, and promoting the use of common software, interfaces, & standards for control and operation for surface exploration and science. The next field test will also attempt to include greater involvement by industry, academia, and other countries/space agencies. This paper will provide an overview of the development and demonstration approach utilized to date, the results of the previous two ISRU-focused field analogue tests in Hawaii, and the current objectives and plans for the 3rd international Hawaii analogue field test.

Man-Machine Integration Design and Analysis System (MIDAS) v5: Augmentations, Motivations, and Directions for Aeronautics Applications

NASA Technical Reports Server (NTRS)

Gore, Brian F.

2011-01-01

As automation and advanced technologies are introduced into transport systems ranging from the Next Generation Air Transportation System termed NextGen, to the advanced surface transportation systems as exemplified by the Intelligent Transportations Systems, to future systems designed for space exploration, there is an increased need to validly predict how the future systems will be vulnerable to error given the demands imposed by the assistive technologies. One formalized approach to study the impact of assistive technologies on the human operator in a safe and non-obtrusive manner is through the use of human performance models (HPMs). HPMs play an integral role when complex human-system designs are proposed, developed, and tested. One HPM tool termed the Man-machine Integration Design and Analysis System (MIDAS) is a NASA Ames Research Center HPM software tool that has been applied to predict human-system performance in various domains since 1986. MIDAS is a dynamic, integrated HPM and simulation environment that facilitates the design, visualization, and computational evaluation of complex man-machine system concepts in simulated operational environments. The paper will discuss a range of aviation specific applications including an approach used to model human error for NASA s Aviation Safety Program, and what-if analyses to evaluate flight deck technologies for NextGen operations. This chapter will culminate by raising two challenges for the field of predictive HPMs for complex human-system designs that evaluate assistive technologies: that of (1) model transparency and (2) model validation.

Mars Surface Environmental Issues

NASA Technical Reports Server (NTRS)

Charles, John

2002-01-01

Planetary exploration by astronauts will require extended periods of habitation on a planet's surface, under the influence of environmental factors that are different from those of Earth and the spacecraft that delivered the crew to the planet. Human exploration of Mars, a possible near-term planetary objective, can be considered a challenging scenario. Mission scenarios currently under consideration call for surface habitation periods of from 1 to 18 months on even the earliest expeditions. Methods: Environmental issues associated with Mars exploration have been investigated by NASA and the National Space Biomedical Research Institute (NSBRI) as part of the Bioastronautics Critical Path Roadmap Project (see http ://criticalpath.jsc.nasa.gov). Results: Arrival on Mars will immediately expose the crew to gravity only 38% of that at Earth's surface in possibly the first prolonged exposure to gravity other than the 1G of Earth's surface and the zero G of weightless space flight, with yet unknown effects on crew physiology. The radiation at Mars' surface is not well documented, although the planet's bulk and even its thin atmosphere may moderate the influx of galactic cosmic radiation and energetic protons from solar flares. Secondary radiation from activated components of the soil must also be considered. Ultrafine and larger respirable and nonrespirable particles in Martian dust introduced into the habitat after surface excursions may induce pulmonary inflammation exacerbated by the additive reactive and oxidizing nature of the dust. Stringent decontamination cannot eliminate mechanical and corrosive effects of the dust on pressure suits and exposed machinery. The biohazard potential of putative indigenous Martian microorganisms may be assessed by comparison with analog environments on Earth. Even in their absence, human microorganisms, if not properly controlled, can be a threat to the crew's health. Conclusions: Mars' surface offers a substantial challenge to the health and safety of future human explorers.

NASA Accountability Report

NASA Technical Reports Server (NTRS)

1997-01-01

NASA is piloting fiscal year (FY) 1997 Accountability Reports, which streamline and upgrade reporting to Congress and the public. The document presents statements by the NASA administrator, and the Chief Financial Officer, followed by an overview of NASA's organizational structure and the planning and budgeting process. The performance of NASA in four strategic enterprises is reviewed: (1) Space Science, (2) Mission to Planet Earth, (3) Human Exploration and Development of Space, and (4) Aeronautics and Space Transportation Technology. Those areas which support the strategic enterprises are also reviewed in a section called Crosscutting Processes. For each of the four enterprises, there is discussion about the long term goals, the short term objectives and the accomplishments during FY 1997. The Crosscutting Processes section reviews issues and accomplishments relating to human resources, procurement, information technology, physical resources, financial management, small and disadvantaged businesses, and policy and plans. Following the discussion about the individual areas is Management's Discussion and Analysis, about NASA's financial statements. This is followed by a report by an independent commercial auditor and the financial statements.

Concordant preferences for opposite-sex signals? Human pheromones and facial characteristics.

PubMed Central

Cornwell, R. Elisabeth; Boothroyd, Lynda; Burt, D. Michael; Feinberg, David R.; Jones, Ben C.; Little, Anthony C.; Pitman, Robert; Whiten, Susie; Perrett, David I.

2004-01-01

We have investigated whether preferences for masculine and feminine characteristics are correlated across two modalities, olfaction and vision. In study 1, subjects rated the pleasantness of putative male (4,16-androstadien-3-one; 5alpha-androst-16-en-3-one) and female (1,3,5 (10),16-estratetraen-3-ol) pheromones, and chose the most attractive face shape from a masculine-feminine continuum for a long- and a short-term relationship. Study 2 replicated study 1 and further explored the effects of relationship context on pheromone ratings. For long-term relationships, women's preferences for masculine face shapes correlated with ratings of 4,16-androstadien-3-one and men's preferences for feminine face shapes correlated with ratings of 1,3,5(10),16-estratetraen-3-ol. These studies link sex-specific preferences for putative human sex pheromones and sexually dimorphic facial characteristics. Our findings suggest that putative sex pheromones and sexually dimorphic facial characteristics convey common information about the quality of potential mates. PMID:15156922

Pax: A permanent base for human habitation of Mars

NASA Technical Reports Server (NTRS)

Moore, Gary T.; Rebholz, Patrick J.; Fieber, Joseph P.; Huebner-Moths, Janis; Paruleski, Kerry L.

1992-01-01

The Advanced Design Program in Space Architecture at the University of Wisconsin-Milwaukee supported the synthesis report and two of its scenarios - 'Architecture 1' and 'Architecture 4' - and the Weaver ExPO report on near-term extraterrestrial explorations during the spring of 1992. The project investigated the implications of different mission scenarios, the Martian environment, supporting technologies, and especially human factors and environment-behavior considerations for the design of the first permanent Martian base. This paper presents the results of that investigation. The paper summarizes site selection, development of habitability design requirements based on environment-behavior research, construction sequencing, and a full concept design and design development for a first permanent Martian base and habitat. The proposed design is presented in terms of an integrative mission scenario and master plan phased through initial operational configuration, base site plan, and design development details of a complete Martian habitat for 18 crew members including all laboratory, mission control, and crew support spaces.

First Lunar Outpost support study

NASA Technical Reports Server (NTRS)

Bartz, Christopher; Cook, John; Rusingizandekwe, Jean-Luc

1993-01-01

The First Lunar Outpost (FLO) is the first manned step in the accomplishment of the Space Exploration Initiative, the Vice President's directive to NASA on the 20th anniversary of the Apollo moon landing. FLO's broad objectives are the establishment of a permanent human presence on the moon, supporting the utilization of extraterrestrial resources in a long-term, sustained program. The primary objective is to emplace and validate the first elements of a man tended outpost on the lunar surface to provide the basis for: (1) establishing, maintaining and expanding human activities and influence across the surface; (2) establishing, maintaining and enhancing human safety and productivity; (3) accommodating space transportation operations to and from the surface; (4) accommodating production of scientific information; (5) exploiting in-situ resources. Secondary objectives are: (1) to conduct local, small scale science (including life science); (2) In-situ resource utilization (ISRU) demonstrations; (3) engineering and operations tests; (4) to characterize the local environment; and (5) to explore locally. The current work is part of ongoing research at the Sasakawa International Center for Space Architecture supporting NASA's First Lunar Outpost initiative. Research at SICSA supporting the First Lunar Outpost initiative has been funded through the Space Exploration Initiatives office at Johnson Space Center. The objectives of the current study are to further develop a module concept from an evaluation of volumetric and programmatic requirements, and pursue a high fidelity design of this concept, with the intention of providing a high fidelity design mockup to research planetary design issues and evaluate future design concepts.

Evaluating everyday competence in older adult couples: epidemiological considerations.

PubMed

Dixon, Roger A

2011-01-01

Among older adults, everyday competence is often expressed in the context of other participating individuals. Although this active human context may be occasionally comprised of mere acquaintances, long-term partners (such as couples) often act as a unit in engaging in everyday actions or reporting on familiar domains. This special section reflects an important movement in aging research to examine couples as an alternative but normatively common unit of analysis. My discussion focuses on 2 main issues. First, I sketch the rationale, logic, expectation and evidence that long-term couples might develop and display unique advantages in everyday competence. Second, I explore the possibilities that epidemiological principles - thus far applied primarily to individual-level aging, decline and disease - may provide concepts or models for research on long-term changes in couple-level adaptation. Copyright © 2010 S. Karger AG, Basel.

Evaluating Everyday Competence in Older Adult Couples: Epidemiological Considerations

PubMed Central

Dixon, Roger A.

2011-01-01

Among older adults, everyday competence is often expressed in the context of other participating individuals. Although this active human context may be occasionally comprised of mere acquaintances, long-term partners (such as couples) often act as a unit in engaging in everyday actions or reporting on familiar domains. This special section reflects an important movement in aging research to examine couples as an alternative but normatively common unit of analysis. My discussion focuses on 2 main issues. First, I sketch the rationale, logic, expectation and evidence that long-term couples might develop and display unique advantages in everyday competence. Second, I explore the possibilities that epidemiological principles – thus far applied primarily to individual-level aging, decline and disease – may provide concepts or models for research on long-term changes in couple-level adaptation. PMID:20733285

The Experientiality of Sustainability: Living with Our Choices

NASA Astrophysics Data System (ADS)

Pritchard, M.

2015-12-01

In an age when the escalating impact of human activity on the global environment has begun to threaten the long-term survival of humanity, increasing focus is being brought to bear on the scientific, social, economic, political, and cultural ramifications of the various courses of action open to individuals and societies across the globe. The intentional and intelligent modification of human behavior to balance environmental impact with human wellbeing is seen as the key to entering what Jeffrey Sachs has called the 'Age of Sustainable Development'. There are mechanisms, legal, socio-cultural, religious, economic, and technological that may ameliorate to varying degrees the environmental impact of human activity. These mechanisms are explored at length in the literature and assessed by their capacity to encourage or compel compliant behavior. They rely heavily on individual and collective choices based on rational self-interest, which is in turn informed by knowledge. The role of education in facilitating sustainable human activity is a key feature of many contributions to the literature. The alarming shortcoming in these discussions is the absence of an effective approach to learned sustainability that may achieve the necessary changes in human behavior and particularly adult choices with respect to daily acts of consumption. Sustainable practices and choices are most effectively produced through immersion in experientially based learning programs aimed at elementary and secondary school students. The experience of sustainable living during the critical phase of personal identity formation is the key to shaping behavior, and not just imparting knowledge. This AGU education session, ED041: Teaching Sustainability and Human Impact through Collaborative Teaching Methods, explores the principles on which such experiential immersion learning contributes to genuine sustainable behaviors and choices through targeted, intelligently designed residential programs.

Human exploration and settlement of Mars - The roles of humans and robots

NASA Technical Reports Server (NTRS)

Duke, Michael B.

1991-01-01

The scientific objectives and strategies for human settlement on Mars are examined in the context of the Space Exploration Initiative (SEI). An integrated strategy for humans and robots in the exploration and settlement of Mars is examined. Such an effort would feature robotic, telerobotic, and human-supervised robotic phases.

Human migration to space: Alternative technological approaches for long-term adaptation to extraterrestrial environments and the implications for human evolution

NASA Astrophysics Data System (ADS)

Lockard, Elizabeth Song

As humans embark upon the next phase of Space exploration---establishing human outposts in low-Earth orbit, on the Moon, and on Mars---the scope of human factors must expand beyond the meager requirements for short-term missions to Space to include issues of comfort and well-being necessary for long-term durations. However, to habitate---to dwell in a place---implies more than creature comforts in order to adapt. Human factors research must also include a phenomenological perspective---an understanding of how we experience the places we live in---in order for a community to be robust and to thrive. The first phase of migration will be an especially tenuous one requiring intensive technological intervention. The modes by which those technologies are implemented will have significant bearing on the process of human adaptation: the nature of the mediation can be either one of domination, subordination, avoidance, or integration. Ultimately, adaptation is best ensured if symbiotic processes of negotiation and cooperation between subject and environment are espoused over acts of conquest or acquiescence. The adaptive mechanisms we choose to develop and employ will have wider implications for long-range human evolution. The transformations we will undergo will be influenced by both the initial decision to migrate to Space (technological), as well as the actual conditions of Space (environmental). Migration to extraterrestrial environments will be unequivocally the most profound catalyst for evolution in the history of humankind---not only for the human species itself but also for the new environments we will eventually inhabit. At the same time, we also find ourselves---via a new generation of bio-, nano-, and digital technologies---in the position to consciously and willfully direct our own evolution. Technology has always been transformative, but in the not-so-distant future, we will soon possess the capacity to radically re-invent ourselves in almost any way conceivable. The discourse on human evolution in Space must be situated in the confluence of these two variables.

Scientific return of a lunar elevator

NASA Astrophysics Data System (ADS)

Eubanks, T. M.; Radley, C. F.

2016-11-01

The concept of a space elevator dates back to Tsilokovsky, but they are not commonly considered in near-term plans for space exploration, perhaps because a terrestrial elevator would not be possible without considerable improvements in tether material. A Lunar Space Elevator (LSE), however, can be built with current technology using commercially available tether polymers. This paper considers missions leading to infrastructure capable of shortening the time, lowering the cost and enhancing the capabilities of robotic and human explorers. These missions use planetary scale tethers, strings many thousands of kilometers long stabilized either by rotation or by gravitational gradients. These systems promise major reduction in transport costs versus chemical rockets, in a rapid timeframe, for a modest investment. Science will thus benefit as well as commercial activities.

Humans in earth orbit and planetary exploration missions; IAA Man in Space Symposium, 8th, Tashkent, Uzbek SSR, Sept. 29-Oct. 3, 1990, Selection of Papers

NASA Technical Reports Server (NTRS)

Grigor'ev, A. I. (Editor); Klein, K. E. (Editor); Nicogossian, A. (Editor)

1991-01-01

The present conference on findings from space life science investigations relevant to long-term earth orbit and planetary exploration missions, as well as considerations for future research projects on these issues, discusses the cardiovascular system and countermeasures against its deterioration in the microgravity environment, cerebral and sensorimotor functions, findings to date in endocrinology and immunology, the musculoskeletal system, and health maintenance and medical care. Also discussed are radiation hazards and protective systems, life-support and habitability factors, and such methodologies and equipment for long space mission research as the use of animal models, novel noninvasive techniques for space crew health monitoring, and an integrated international aerospace medical information system.

Global climate change, war, and population decline in recent human history

PubMed Central

Zhang, David D.; Brecke, Peter; Lee, Harry F.; He, Yuan-Qing; Zhang, Jane

2007-01-01

Although scientists have warned of possible social perils resulting from climate change, the impacts of long-term climate change on social unrest and population collapse have not been quantitatively investigated. In this study, high-resolution paleo-climatic data have been used to explore at a macroscale the effects of climate change on the outbreak of war and population decline in the preindustrial era. We show that long-term fluctuations of war frequency and population changes followed the cycles of temperature change. Further analyses show that cooling impeded agricultural production, which brought about a series of serious social problems, including price inflation, then successively war outbreak, famine, and population decline successively. The findings suggest that worldwide and synchronistic war–peace, population, and price cycles in recent centuries have been driven mainly by long-term climate change. The findings also imply that social mechanisms that might mitigate the impact of climate change were not significantly effective during the study period. Climate change may thus have played a more important role and imposed a wider ranging effect on human civilization than has so far been suggested. Findings of this research may lend an additional dimension to the classic concepts of Malthusianism and Darwinism. PMID:18048343

Information Infrastructure, Information Environments, and Long-Term Collaboration

NASA Astrophysics Data System (ADS)

Baker, K. S.; Pennington, D. D.

2009-12-01

Information infrastructure that supports collaborative science is a complex system of people, organizational arrangements, and tools that require co-management. Contemporary studies are exploring how to establish and characterize effective collaborative information environments. Collaboration depends on the flow of information across the human and technical system components through mechanisms that create linkages, both conceptual and technical. This transcends the need for requirements solicitation and usability studies, highlighting synergistic interactions between humans and technology that can lead to emergence of group level cognitive properties. We consider the ramifications of placing priority on establishing new metaphors and new types of learning environments located near-to-data-origin for the field sciences. In addition to changes in terms of participant engagement, there are implications in terms of innovative contributions to the design of information systems and data exchange. While data integration occurs in the minds of individual participants, it may be facilitated by collaborative thinking and community infrastructure. Existing learning frameworks - from Maslow’s hierarchy of needs to organizational learning - require modification and extension if effective approaches to decentralized information management and systems design are to emerge. Case studies relating to data integration include ecological community projects: development of cross-disciplinary conceptual maps and of a community unit registry.

Global climate change, war, and population decline in recent human history.

PubMed

Zhang, David D; Brecke, Peter; Lee, Harry F; He, Yuan-Qing; Zhang, Jane

2007-12-04

Although scientists have warned of possible social perils resulting from climate change, the impacts of long-term climate change on social unrest and population collapse have not been quantitatively investigated. In this study, high-resolution paleo-climatic data have been used to explore at a macroscale the effects of climate change on the outbreak of war and population decline in the preindustrial era. We show that long-term fluctuations of war frequency and population changes followed the cycles of temperature change. Further analyses show that cooling impeded agricultural production, which brought about a series of serious social problems, including price inflation, then successively war outbreak, famine, and population decline successively. The findings suggest that worldwide and synchronistic war-peace, population, and price cycles in recent centuries have been driven mainly by long-term climate change. The findings also imply that social mechanisms that might mitigate the impact of climate change were not significantly effective during the study period. Climate change may thus have played a more important role and imposed a wider ranging effect on human civilization than has so far been suggested. Findings of this research may lend an additional dimension to the classic concepts of Malthusianism and Darwinism.

Economic and Nutritional Analyses Offer Substantial Synergies for Understanding Human Nutrition1

PubMed Central

Alderman, Harold; Behrman, Jere R.; Hoddinott, John

2007-01-01

There is growing recognition that interventions designed to improve human nutritional status have, in addition to their intrinsic value, instrumental value in terms of economic outcomes. In many cases, productivity gains alone provide sufficient economic returns to justify investments using benefit and cost criteria. The often-held belief that nutrition programs are welfare interventions that divert resources that could be better used in other ways to raise national incomes is incorrect. Many investments in nutrition are in fact very good economic investments. This recognition has developed out of work that integrates insights from nutrition and economics. Further exploration of this interface is the focus of this article, which seeks: 1) to outline recent contributions that integrate research results from both economics and nutrition, particularly in the context of poor countries; and 2) to describe some areas in which enhanced collaboration is likely to have substantial payoffs in terms of both improved knowledge and more informed policy choices. Collaborative cross-disciplinary research on the topics described here is likely to have substantial payoffs, not only in terms of our understanding of nutritional and economic issues, but also in the improved design of programs and policies that seek to benefit nutritional-related outcomes. PMID:17311936

Economic and nutritional analyses offer substantial synergies for understanding human nutrition.

PubMed

Alderman, Harold; Behrman, Jere R; Hoddinott, John

2007-03-01

There is growing recognition that interventions designed to improve human nutritional status have, in addition to their intrinsic value, instrumental value in terms of economic outcomes. In many cases, productivity gains alone provide sufficient economic returns to justify investments using benefit and cost criteria. The often-held belief that nutrition programs are welfare interventions that divert resources that could be better used in other ways to raise national incomes is incorrect. Many investments in nutrition are in fact very good economic investments. This recognition has developed out of work that integrates insights from nutrition and economics. Further exploration of this interface is the focus of this article, which seeks: 1) to outline recent contributions that integrate research results from both economics and nutrition, particularly in the context of poor countries; and 2) to describe some areas in which enhanced collaboration is likely to have substantial payoffs in terms of both improved knowledge and more informed policy choices. Collaborative cross-disciplinary research on the topics described here is likely to have substantial payoffs, not only in terms of our understanding of nutritional and economic issues, but also in the improved design of programs and policies that seek to benefit nutritional-related outcomes.

R/S analysis of reaction time in Neuron Type Test for human activity in civil aviation

NASA Astrophysics Data System (ADS)

Zhang, Hong-Yan; Kang, Ming-Cui; Li, Jing-Qiang; Liu, Hai-Tao

2017-03-01

Human factors become the most serious problem leading to accidents of civil aviation, which stimulates the design and analysis of Neuron Type Test (NTT) system to explore the intrinsic properties and patterns behind the behaviors of professionals and students in civil aviation. In the experiment, normal practitioners' reaction time sequences, collected from NTT, exhibit log-normal distribution approximately. We apply the χ2 test to compute the goodness-of-fit by transforming the time sequence with Box-Cox transformation to cluster practitioners. The long-term correlation of different individual practitioner's time sequence is represented by the Hurst exponent via Rescaled Range Analysis, also named by Range/Standard deviation (R/S) Analysis. The different Hurst exponent suggests the existence of different collective behavior and different intrinsic patterns of human factors in civil aviation.

Suicide among animals: a review of evidence.

PubMed

Preti, Antonio

2007-12-01

Naturalists have not identified suicide in nonhuman species in field situations, despite intensive study of thousands of animal species. In this review, evidence on suicidal behavior among animals is analyzed to discover analogies with human suicidal behavior. Literature was retrieved by exploring Medline/PubMed and PsychINFO databases (1967-2007) and through manual literature searches. Keyword terms were "suicide or suicidal behavior" and "animal or animal behavior." Few empirical investigations have been carried out on this topic. Nevertheless, sparse evidence supports some resemblance between the self-endangering behavior observed in the animal kingdom, particularly in animals held in captivity or put under pressure by environmental challenges, and suicidal behavior among humans. Animal models have contributed to the study of both normal and pathological human behaviors: discovering some correlates of suicide among animals could be a valid contribution to the field.

Evaluation of nitrate-substituted pseudocholine esters of aspirin as potential nitro-aspirins.

PubMed

Gilmer, John F; Moriarty, Louise M; Clancy, John M

2007-06-01

Herein we explore some designs for nitro-aspirins, compounds potentially capable of releasing both aspirin and nitric oxide in vivo. A series of nitrate-bearing alkyl esters of aspirin were prepared based on the choline ester template preferred by human plasma butyrylcholinesterase. The degradation kinetics of the compounds were followed in human plasma solution. All compounds underwent hydrolysis rapidly (t(1/2) approximately 1min) but generating exclusively the corresponding nitro-salicylate. The one exception, an N-propyl, N-nitroxyethyl aminoethanol ester produced 9.2% aspirin in molar terms indicating that the nitro-aspirin objective is probably achievable if due cognisance can be paid to the demands of the activating enzyme. Even at this low level of aspirin release, this compound is the most successful nitro-aspirin reported to date in the key human plasma model.

Drought and flood in the Anthropocene: feedback mechanisms in reservoir operation

NASA Astrophysics Data System (ADS)

Di Baldassarre, Giuliano; Martinez, Fabian; Kalantari, Zahra; Viglione, Alberto

2017-03-01

Over the last few decades, numerous studies have investigated human impacts on drought and flood events, while conversely other studies have explored human responses to hydrological extremes. Yet, there is still little understanding about the dynamics resulting from their interplay, i.e. both impacts and responses. Current quantitative methods therefore can fail to assess future risk dynamics and, as a result, while risk reduction strategies built on these methods often work in the short term, they tend to lead to unintended consequences in the long term. In this paper, we review the puzzles and dynamics resulting from the interplay of society and hydrological extremes, and describe an initial effort to model hydrological extremes in the Anthropocene. In particular, we first discuss the need for a novel approach to explicitly account for human interactions with both drought and flood events, and then present a stylized model simulating the reciprocal effects between hydrological extremes and changing reservoir operation rules. Lastly, we highlight the unprecedented opportunity offered by the current proliferation of big data to unravel the coevolution of hydrological extremes and society across scales and along gradients of social and hydrological conditions.

Time Prediction Models for Echinococcosis Based on Gray System Theory and Epidemic Dynamics.

PubMed

Zhang, Liping; Wang, Li; Zheng, Yanling; Wang, Kai; Zhang, Xueliang; Zheng, Yujian

2017-03-04

Echinococcosis, which can seriously harm human health and animal husbandry production, has become an endemic in the Xinjiang Uygur Autonomous Region of China. In order to explore an effective human Echinococcosis forecasting model in Xinjiang, three grey models, namely, the traditional grey GM(1,1) model, the Grey-Periodic Extensional Combinatorial Model (PECGM(1,1)), and the Modified Grey Model using Fourier Series (FGM(1,1)), in addition to a multiplicative seasonal ARIMA(1,0,1)(1,1,0)₄ model, are applied in this study for short-term predictions. The accuracy of the different grey models is also investigated. The simulation results show that the FGM(1,1) model has a higher performance ability, not only for model fitting, but also for forecasting. Furthermore, considering the stability and the modeling precision in the long run, a dynamic epidemic prediction model based on the transmission mechanism of Echinococcosis is also established for long-term predictions. Results demonstrate that the dynamic epidemic prediction model is capable of identifying the future tendency. The number of human Echinococcosis cases will increase steadily over the next 25 years, reaching a peak of about 1250 cases, before eventually witnessing a slow decline, until it finally ends.

Technology Needs to Support Future Mars Exploration

NASA Technical Reports Server (NTRS)

Nilsen, Erik N.; Baker, John; Lillard, Randolph P.

2013-01-01

The Mars Program Planning Group (MPPG) under the direction of Dr. Orlando Figueroa, was chartered to develop options for a program-level architecture for robotic exploration of Mars consistent with the objective to send humans to Mars in the 2030's. Scientific pathways were defined for future exploration, and multiple architectural options were developed that meet current science goals and support the future human exploration objectives. Integral to the process was the identification of critical technologies which enable the future scientific and human exploration goals. This paper describes the process for technology capabilities identification and examines the critical capability needs identified in the MPPG process. Several critical enabling technologies that have been identified to support the robotic exploration goals and with potential feedforward application to human exploration goals. Potential roadmaps for the development and validation of these technologies are discussed, including options for subscale technology demonstrations of future human exploration technologies on robotic missions.

KSC-04pd1309

NASA Image and Video Library

2004-06-17

KENNEDY SPACE CENTER, FLA. - In the KSC Space Life Sciences Lab’s Resource Recovery lab, bioengineer Tony Rector checks the ARMS reactor vessel. ARMS, or Aerobic Rotational Membrane System, is a wastewater processing project being tested for use on the International Space Station to collect, clean and reuse wastewater. It could be adapted for use on the Moon and Mars. The Lab is exploring various aspects of a bioregenerative life support system. Such research and technology development will be crucial to long-term habitation of space by humans.

KSC-04pd1310

NASA Image and Video Library

2004-06-17

KENNEDY SPACE CENTER, FLA. - In the KSC Space Life Sciences Lab’s Resource Recovery lab, bioengineer Tony Rector checks the clear plexiglass ARMS reactor vessel. ARMS, or Aerobic Rotational Membrane System, is a wastewater processing project being tested for use on the International Space Station to collect, clean and reuse wastewater. It could be adapted for use on the Moon and Mars. The Lab is exploring various aspects of a bioregenerative life support system. Such research and technology development will be crucial to long-term habitation of space by humans.

KSC-04PD-1312

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. In a plant growth chamber in the KSC Space Life Sciences Lab, plant physiologist Ray Wheeler checks onions being grown using hydroponic techniques. The other plants are Bibb lettuce (left) and radishes (right). Wheeler and other colleagues are researching plant growth under different types of light, different CO2 concentrations and temperatures. The Lab is exploring various aspects of a bioregenerative life support system. Such research and technology development will be crucial to long-term habitation of space by humans.

KSC-04pd1312

NASA Image and Video Library

2004-06-17

KENNEDY SPACE CENTER, FLA. - In a plant growth chamber in the KSC Space Life Sciences Lab, plant physiologist Ray Wheeler checks onions being grown using hydroponic techniques. The other plants are Bibb lettuce (left) and radishes (right). Wheeler and other colleagues are researching plant growth under different types of light, different CO2 concentrations and temperatures. The Lab is exploring various aspects of a bioregenerative life support system. Such research and technology development will be crucial to long-term habitation of space by humans.

Digital visual communications using a Perceptual Components Architecture

NASA Technical Reports Server (NTRS)

Watson, Andrew B.

1991-01-01

The next era of space exploration will generate extraordinary volumes of image data, and management of this image data is beyond current technical capabilities. We propose a strategy for coding visual information that exploits the known properties of early human vision. This Perceptual Components Architecture codes images and image sequences in terms of discrete samples from limited bands of color, spatial frequency, orientation, and temporal frequency. This spatiotemporal pyramid offers efficiency (low bit rate), variable resolution, device independence, error-tolerance, and extensibility.

Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor.

PubMed

Kratochwil, Nicole A; Triyatni, Miriam; Mueller, Martina B; Klammers, Florian; Leonard, Brian; Turley, Dan; Schmaler, Josephine; Ekiciler, Aynur; Molitor, Birgit; Walter, Isabelle; Gonsard, Pierre-Alexis; Tournillac, Charles A; Durrwell, Alexandre; Marschmann, Michaela; Jones, Russell; Ullah, Mohammed; Boess, Franziska; Ottaviani, Giorgio; Jin, Yuyan; Parrott, Neil J; Fowler, Stephen

2018-05-01

Long-term in vitro liver models are now widely explored for human hepatic metabolic clearance prediction, enzyme phenotyping, cross-species metabolism, comparison of low clearance drugs, and induction studies. Here, we present studies using a long-term liver model, which show how metabolism and active transport, drug-drug interactions, and enzyme induction in healthy and diseased states, such as hepatitis B virus (HBV) infection, may be assessed in a single test system to enable effective data integration for physiologically based pharmacokinetic (PBPK) modeling. The approach is exemplified in the case of (3S)-4-[[(4R)-4-(2-Chloro-4-fluorophenyl)-5-methoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid RO6889678, a novel inhibitor of HBV with a complex absorption, distribution, metabolism, and excretion (ADME) profile. RO6889678 showed an intracellular enrichment of 78-fold in hepatocytes, with an apparent intrinsic clearance of 5.2 µ l/min per mg protein and uptake and biliary clearances of 2.6 and 1.6 µ l/min per mg protein, respectively. When apparent intrinsic clearance was incorporated into a PBPK model, the simulated oral human profiles were in good agreement with observed data at low doses but were underestimated at high doses due to unexpected overproportional increases in exposure with dose. In addition, the induction potential of RO6889678 on cytochrome P450 (P450) enzymes and transporters at steady state was assessed and cotreatment with ritonavir revealed a complex drug-drug interaction with concurrent P450 inhibition and moderate UDP-glucuronosyltransferase induction. Furthermore, we report on the first evaluation of in vitro pharmacokinetics studies using HBV-infected HepatoPac cocultures. Thus, long-term liver models have great potential as translational research tools exploring pharmacokinetics of novel drugs in vitro in health and disease. Copyright © 2018 The Author(s).

The Potential Impact of Mars' Atmospheric Dust on Future Human Exploration of the Red Planet

NASA Astrophysics Data System (ADS)

Winterhalter, D.; Levine, J. S.; Kerschmann, R.; Beaty, D. W.; Carrier, B. L.; Ashley, J. W.

2017-12-01

With the increasing focus by NASA and other space agencies on a crewed mission to Mars in the 2039 time-frame, many Mars-specific environmental factors are now starting to be considered by NASA and other engineering teams. Learning from NASA's Apollo Missions to the Moon, where lunar dust turned out to be a significant challenge to mission and crew safety, attention is now turning to the dust in Mars' atmosphere and regolith. To start the process of identifying possible dust-caused challenges to the human presence on Mars, and thus aid early engineering and mission design efforts, the NASA Engineering and Safety Center (NESC) Robotic Spacecraft Technical Discipline Team organized and conducted a Workshop on the "Dust in Mars' Atmosphere and Its Impact on the Human Exploration of Mars", held at the Lunar and Planetary Institute (LPI), Houston, TX, June 13-15, 2017. The workshop addressed the following general areas: 1. What is known about Mars' dust in terms of its physical and chemical properties, its local and global abundance and composition, and its variability.2. What is the impact of Mars atmospheric dust on human health.3. What is the impact of Mars atmospheric dust on surface mechanical systems (e.g., spacesuits, habitats, mobility systems, etc.). We present the top priority issues identified in the workshop.

Space Toxicology: Environmental Health Considerations during Spaceflight Operations and Potential Paths for Research

NASA Technical Reports Server (NTRS)

Khan-Mayberry, Noreen N.; Sundaresan, Alemalu

2009-01-01

Space Toxicology is a specialized discipline for spaceflight, space habitation and occupation of celestial bodies including planets, moons and asteroids [1]. Astronaut explorers face unique challenges to their health while working and living with limited resources for rescue and medical care during space operation. At its core the practice of space toxicology to identify, assess and predict potential chemical contaminants and limit the astronaut s exposure to these environmental factors in order to protect crew health. Space toxicologists are also charged with setting safe exposure limits that will protect the astronaut against a multitude of chemical exposures, in a physiologically altered state. In order to maintain sustained occupation in space, toxicological risks are gauged and managed within the context of isolation, continual exposures, reuse of air and water, limited rescue options, and the necessary use of highly toxic compounds required for propulsion. As the space program move towards human presence and exploration other celestial bodies in situ toxicological risks, such as inhalation of unusual and/or reactive mineral dusts must also be analyzed and controlled. Placing humans for long-term presence in space creates several problems and challenges to the long-term health of the crew, such as bone-loss and immunological challenges and has spurred research into acute, chronic and episodic exposure of the pulmonary system to mineral dusts [2]. NASA has demonstrated that lunar soil contains several types of reactive dusts, including an extremely fine respirable component. In order to protect astronaut health, NASA is now investigating the toxicity of this unique class of dusts. Understanding how these reactive components behave "biochemically" in a moisture-rich pulmonary environment will aid in determining how toxic these particles are to humans. The data obtained from toxicological examination of lunar dusts will determine the human risk criteria for lunar dust exposure and produce a lunar health standard.

NASA In-Situ Resource Utilization (ISRU) Technology and Development Project Overview

NASA Technical Reports Server (NTRS)

Sanders, Gerald B.; Lason, William E.; Sacksteder, Kurt R.; Mclemore, Carole; Johnson, Kenneth

2008-01-01

Since the Vision for Space Exploration (VSE) was released in 2004, NASA, in conjunction with international space agencies, industry, and academia, has continued to define and refine plans for sustained and affordable robotic and human exploration of the Moon and beyond. With the goal of establishing a lunar Outpost on the Moon to extend human presence, pursue scientific activities, use the Moon to prepare for future human missions to Mars, and expand Earth s economic sphere, a change in how space exploration is performed is required. One area that opens up the possibility for the first time of breaking our reliance on Earth supplied consumables and learn to live off the land is In-Situ Resource Utilization (ISRU). ISRU, which involves the extraction and processing of space resources into useful products, can have a substantial impact on mission and architecture concepts. In particular, the ability to make propellants, life support consumables, and fuel cell reagents can significantly reduce the cost, mass, and risk of sustained human activities beyond Earth. However, ISRU is an unproven capability for human lunar exploration and can not be put in the critical path of lunar Outpost success until it has been proven. Therefore, ISRU development and deployment needs to take incremental steps toward the desired end state. To ensure ISRU capabilities are available for pre-Outpost and Outpost deployment by 2020, and mission and architecture planners are confident that ISRU can meet initial and long term mission requirements, the ISRU Project is developing technologies and systems in three critical areas: (1) Regolith Excavation, Handling and Material Transportation; (2) Oxygen Extraction from Regolith; and (3) Volatile Extraction and Resource Prospecting, and in four development stages: (I) Demonstrate feasibility; (II) Evolve system w/ improved technologies; (III) Develop one or more systems to TRL 6 before start of flight development; and (IV) Flight development for Outpost. To minimize cost and ensure that ISRU technologies, systems, and functions are integrated properly into the Outpost, technology development efforts are being coordinated with other development areas such as Surface Mobility, Surface Power, Life Support, EVA, and Propulsion. Lastly, laboratory and field system-level tests and demonstrations will be performed as often as possible to demonstrate improvements in: Capabilities (ex. digging deeper); Performance (ex. lower power); and Duration (ex. more autonomy or more robustness). This presentation will provide the status of work performed to date within the NASA ISRU project with respect to technology and system development and field demonstration activities, as well as the current strategy to implement ISRU in future robotic and human lunar exploration missions.

Advanced Water Recovery Technologies for Long Duration Space Exploration Missions

NASA Technical Reports Server (NTRS)

Liu, Scan X.

2005-01-01

Extended-duration space travel and habitation require recovering water from wastewater generated in spacecrafts and extraterrestrial outposts since the largest consumable for human life support is water. Many wastewater treatment technologies used for terrestrial applications are adoptable to extraterrestrial situations but challenges remain as constraints of space flights and habitation impose severe limitations of these technologies. Membrane-based technologies, particularly membrane filtration, have been widely studied by NASA and NASA-funded research groups for possible applications in space wastewater treatment. The advantages of membrane filtration are apparent: it is energy-efficient and compact, needs little consumable other than replacement membranes and cleaning agents, and doesn't involve multiphase flow, which is big plus for operations under microgravity environment. However, membrane lifespan and performance are affected by the phenomena of concentration polarization and membrane fouling. This article attempts to survey current status of membrane technologies related to wastewater treatment and desalination in the context of space exploration and quantify them in terms of readiness level for space exploration. This paper also makes specific recommendations and predictions on how scientist and engineers involving designing, testing, and developing space-certified membrane-based advanced water recovery technologies can improve the likelihood of successful development of an effective regenerative human life support system for long-duration space missions.

Past, present, and future life on Mars

NASA Technical Reports Server (NTRS)

McKay, C. P.

1998-01-01

Although the Viking results indicated that the surface of Mars is dry and lifeless, there is direct geomorphological evidence that Mars had large amounts of liquid water on its surface in the past. From a biological perspective the existence of liquid water, by itself, motivates the question of the origin of life on Mars. One of the martian meteorites dates back to this early period and may contain evidence consistent with life. The Mars environment 3.5 to 4.0 Gyr ago was comparable to that on the Earth at this time in that both contained liquid water. Life had originated on Earth and reached a fair degree of biological sophistication by 3.5 Gyr ago. To determine if life similarly arose on Mars may require extensive robotic exploration and ultimately human exploration. Intensive exploration of Mars will require a continued presence on the Martian surface and the development of a self sustaining community in which humans can live and work for very long periods of time. A permanent Mars research station can obtain its life support requirements directly from the martian environment enabling a high degree of self-sufficiency. In the longer term, it is possible that in the future we might restore a habitable climate on Mars, returning it to the life-bearing state it may have enjoyed early in its history.

Past, present, and future life on Mars.

PubMed

McKay, C P

1998-05-01

Although the Viking results indicated that the surface of Mars is dry and lifeless, there is direct geomorphological evidence that Mars had large amounts of liquid water on its surface in the past. From a biological perspective the existence of liquid water, by itself, motivates the question of the origin of life on Mars. One of the martian meteorites dates back to this early period and may contain evidence consistent with life. The Mars environment 3.5 to 4.0 Gyr ago was comparable to that on the Earth at this time in that both contained liquid water. Life had originated on Earth and reached a fair degree of biological sophistication by 3.5 Gyr ago. To determine if life similarly arose on Mars may require extensive robotic exploration and ultimately human exploration. Intensive exploration of Mars will require a continued presence on the Martian surface and the development of a self sustaining community in which humans can live and work for very long periods of time. A permanent Mars research station can obtain its life support requirements directly from the martian environment enabling a high degree of self-sufficiency. In the longer term, it is possible that in the future we might restore a habitable climate on Mars, returning it to the life-bearing state it may have enjoyed early in its history.

A Flexible Path for Human and Robotic Space Exploration

NASA Technical Reports Server (NTRS)

Korsmeyer, David J.; Landis, Robert; Merrill, Raymond Gabriel; Mazanek, Daniel D.; Falck, Robert D.; Adams, Robert B.

2010-01-01

During the summer of 2009, a flexible path scenario for human and robotic space exploration was developed that enables frequent, measured, and publicly notable human exploration of space beyond low-Earth orbit (LEO). The formulation of this scenario was in support of the Exploration Beyond LEO subcommittee of the Review of U.S. Human Space Flight Plans Committee that was commissioned by President Obama. Exploration mission sequences that allow humans to visit a wide number of inner solar system destinations were investigated. The scope of destinations included the Earth-Moon and Earth-Sun Lagrange points, near-Earth objects (NEOs), the Moon, and Mars and its moons. The missions examined assumed the use of Constellation Program elements along with existing launch vehicles and proposed augmentations. Additionally, robotic missions were envisioned as complements to human exploration through precursor missions, as crew emplaced scientific investigations, and as sample gathering assistants to the human crews. The focus of the flexible path approach was to gain ever-increasing operational experience through human exploration missions ranging from a few weeks to several years in duration, beginning in deep space beyond LEO and evolving to landings on the Moon and eventually Mars.

Correlates of violence in Guinea's Maison Centrale Prison: a statistical approach to documenting human rights abuses.

PubMed

Osborn, Ronald E

2010-12-15

Les Mêmes Droits Pour Tous (MDT) is a human rights NGO in Guinea, West Africa that focuses on the rights of prisoners in Maison Centrale, the country's largest prison located in the capital city of Conakry. In 2007, MDT completed a survey of the prison population to assess basic legal and human rights conditions. This article uses statistical tools to explore MDT's survey results in greater depth, shedding light on human rights violations in Guinea. It contributes to human rights literature that argues for greater use of econometric tools in rights reporting, and demonstrates how human rights practitioners and academics can work together to construct an etiology of violence and torture by state actors, as physical violence is perhaps the most extreme violation of the individual's right to health. Copyright © 2010 Osborn. This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

Commercial Contributions to the Success of the HEDS Enterprise: A Working Model

NASA Technical Reports Server (NTRS)

Nall, Mark; Askew, Ray

2000-01-01

The future of NASA involves the exploration of space beyond the confines of orbit about the Earth. This includes robotic investigations and Human Exploration and Development of Space (HEDS). The HEDS Strategic Plan states: "HEDS will join with the private sector to stimulate opportunities for commercial development in space as a key to future settlement. Near-term efforts will emphasize joint pilot projects that provide clear benefit to Earth from the development of near-Earth space." In support of this endeavor, NASA has established the Commercial Development of Space as a prime goal and is exploring all the ways in which NASA might make contributions to this development. NASA has long supported the development of space for commercial use. In 1985 it formally established and provided funds to support a program which created a number of joint ventures between universities and industry for this purpose. These were known as Centers for the Commercial Development of Space (CCDS). In 1999 NASA established a broader policy on commercialization with the aim of encouraging near-term commercial investment in conjunction with the International Space Station. Joint pilot projects will be initiated to stimulate this near-term investment. The long-term development of commercial concepts utilizing space access continues through the activities of the Commercial Space Centers (CSC), a sub-set of the original CCDS group. These Centers primarily require access to space for the conduct of their work. The remainder of the initial Centers focus on the development of tools and infrastructure to support users of the space environment. It is in this arena that long term development for commercial use and infrastructure development will occur. This paper will provide a retrospective examination of the Commercial Centers, the variety of models employed, the lessons learned, and the progress to date. This review will provide the bases for how successful models can be employed to accelerate private investment in the development of the infrastructure necessary for the success of the HEDS enterprise.

Human factors issues in the use of artificial intelligence in air traffic control. October 1990 Workshop

NASA Technical Reports Server (NTRS)

Hockaday, Stephen; Kuhlenschmidt, Sharon (Editor)

1991-01-01

The objective of the workshop was to explore the role of human factors in facilitating the introduction of artificial intelligence (AI) to advanced air traffic control (ATC) automation concepts. AI is an umbrella term which is continually expanding to cover a variety of techniques where machines are performing actions taken based upon dynamic, external stimuli. AI methods can be implemented using more traditional programming languages such as LISP or PROLOG, or they can be implemented using state-of-the-art techniques such as object-oriented programming, neural nets (hardware or software), and knowledge based expert systems. As this technology advances and as increasingly powerful computing platforms become available, the use of AI to enhance ATC systems can be realized. Substantial efforts along these lines are already being undertaken at the FAA Technical Center, NASA Ames Research Center, academic institutions, industry, and elsewhere. Although it is clear that the technology is ripe for bringing computer automation to ATC systems, the proper scope and role of automation are not at all apparent. The major concern is how to combine human controllers with computer technology. A wide spectrum of options exists, ranging from using automation only to provide extra tools to augment decision making by human controllers to turning over moment-by-moment control to automated systems and using humans as supervisors and system managers. Across this spectrum, it is now obvious that the difficulties that occur when tying human and automated systems together must be resolved so that automation can be introduced safely and effectively. The focus of the workshop was to further explore the role of injecting AI into ATC systems and to identify the human factors that need to be considered for successful application of the technology to present and future ATC systems.

Artificial Gravity Research Project

NASA Technical Reports Server (NTRS)

Kamman, Michelle R.; Paloski, William H.

2005-01-01

Protecting the health, safety, and performance of exploration-class mission crews against the physiological deconditioning resulting from long-term weightlessness during transit and long-term hypogravity during surface operations will require effective, multi-system countermeasures. Artificial gravity (AG), which would replace terrestrial gravity with inertial forces generated by rotating the transit vehicle or by a human centrifuge device within the transit vehicle or surface habitat, has long been considered a potential solution. However, despite its attractiveness as an efficient, multi-system countermeasure and its potential for improving the environment and simplifying operational activities (e.g., WCS, galley, etc.), much still needs to be learned regarding the human response to rotating environments before AG can be successfully implemented. This paper will describe our approach for developing and implementing a rigorous AG Research Project to address the key biomedical research questions that must be answered before developing effective AG countermeasure implementation strategies for exploration-class missions. The AG Research Project will be performed at JSC, ARC, extramural academic and government research venues, and international partner facilities maintained by DLR and IMBP. The Project includes three major ground-based human research subprojects that will lead to flight testing of intermittent short-radius AG in ISS crewmembers after 201 0, continuous long-radius AG in CEV crews transiting to and from the Moon, and intermittent short-radius AG plus exercise in lunar habitats. These human ground-based subprojects include: 1) a directed, managed international short-radius project to investigate the multi-system effectiveness of intermittent AG in human subjects deconditioned by bed rest, 2) a directed, managed long-radius project to investigate the capacity of humans to live and work for extended periods in rotating environments, and 3) a focused, investigator-initiated project to investigate system-specific adaptation to and from rotating environments. The AG Research Project also includes two major animal research subprojects: 1) a directed, managed ground-based subproject using rodents and, possibly, sub-human primates, to address mechanistic issues that cannot be studied in humans, to rapidly develop higher sample numbers than can be achieved in the human subprojects, and to establish feasible parameter operating bands to reduce the breadth of the human subprojects, and 2) a flight subproject using rodents to estimate the physiological effects of long term exposure to hypogravity and to investigate the effects of contamination by terrestrial gravity in estimating AG effectiveness. The animal flight subproject would be performed aboard ISS using the CAM module in approximately the 2008-201 1 timeframe. The paper will first present an overview of the key biomedical research questions to be answered. It will then describe the overall approaches to be utilized in developing and implementing the AG Research Project, including definition of the intended scientific research, management and development approaches, identification of roles and responsibilities, risk management, and definition of project deliverables. The primary focus of the paper will be on the first of the three ground-based human research subprojects, since it is the only one currently in development and is scheduled to start active subject investigations in April of 2005.

Measuring infant attachment security in rhesus macaques (Macaca mulatta): adaptation of the attachment Q-set.

PubMed

Warfield, James J; Kondo-Ikemura, Kiyomi; Waters, Everett

2011-02-01

John Bowlby defined offspring-parent attachment as a relationship in which an infant or child uses one or a few preferred adults as a secure base from which to explore and as a haven of safety. He defined attachment security in terms of confidence in the adult's availability and responsiveness and the smooth organization of exploration and proximity seeking. Developmental psychologists have found this perspective productive in both observational and laboratory research. At the same time, they emphasize that such a construct cannot be operationalized in terms of one or a few behaviors. Instead, naturalistic observations of human infant attachment typically employ the Q-sort method to develop the Attachment q-set (AQS), 90 behaviorally descriptive items sorted in terms of how characteristic each item is of the infant's typical behavior. Meta-analyses of research using the AQS attest to its reliability and validity. This article reports an adaptation of the AQS to the task of assessing infant attachment security in nonhuman primates and illustrates its use. The availability of comparable measures of attachment security will contribute to an expanded understanding of patterns of attachment behavior in nonhuman primate societies and will facilitate interaction between comparative and developmental psychologists. © 2010 Wiley-Liss, Inc.

Functional magnetic resonance imaging can be used to explore tactile and nociceptive processing in the infant brain

PubMed Central

Williams, Gemma; Fabrizi, Lorenzo; Meek, Judith; Jackson, Deborah; Tracey, Irene; Robertson, Nicola; Slater, Rebeccah; Fitzgerald, Maria

2015-01-01

Aim Despite the importance of neonatal skin stimulation, little is known about activation of the newborn human infant brain by sensory stimulation of the skin. We carried out functional magnetic resonance imaging (fMRI) to assess the feasibility of measuring brain activation to a range of mechanical stimuli applied to the skin of neonatal infants. Methods We studied 19 term infants with a mean age of 13 days. Brain activation was measured in response to brushing, von Frey hair (vFh) punctate stimulation and, in one case, nontissue damaging pinprick stimulation of the plantar surface of the foot. Initial whole brain analysis was followed by region of interest analysis of specific brain areas. Results Distinct patterns of functional brain activation were evoked by brush and vFh punctate stimulation, which were reduced, but still present, under chloral hydrate sedation. Brain activation increased with increasing stimulus intensity. The feasibility of using pinprick stimulation in fMRI studies was established in one unsedated healthy full-term infant. Conclusion Distinct brain activity patterns can be measured in response to different modalities and intensities of skin sensory stimulation in term infants. This indicates the potential for fMRI studies in exploring tactile and nociceptive processing in the infant brain. PMID:25358870

An exploration of how to define and measure the evolution of behavior, learning, memory and mind across the full phylogenetic tree of life

PubMed Central

Eisenstein, E. M.; Eisenstein, D. L.; Sarma, J. S. M.

2016-01-01

ABSTRACT There are probably few terms in evolutionary studies regarding neuroscience issues that are used more frequently than ‘behavior', ‘learning', ‘memory', and ‘mind'. Yet there are probably as many different meanings of these terms as there are users of them. Further, investigators in such studies, while recognizing the full phylogenetic spectrum of life and the evolution of these phenomena, rarely go beyond mammals and other vertebrates in their investigations; invertebrates are sometimes included. What is rarely taken into consideration, though, is that to fully understand the evolution and significance for survival of these phenomena across phylogeny, it is essential that they be measured and compared in the same units of measurement across the full phylogenetic spectrum from aneural bacteria and protozoa to humans. This paper explores how these terms are generally used as well as how they might be operationally defined and measured to facilitate uniform examination and comparisons across the full phylogenetic spectrum of life. This paper has 2 goals: (1) to provide models for measuring the evolution of ‘behavior' and its changes across the full phylogenetic spectrum, and (2) to explain why ‘mind phenomena' cannot be measured scientifically at the present time. PMID:27489578

Linking brains and brawn: exercise and the evolution of human neurobiology.

PubMed

Raichlen, David A; Polk, John D

2013-01-07

The hunting and gathering lifestyle adopted by human ancestors around 2 Ma required a large increase in aerobic activity. High levels of physical activity altered the shape of the human body, enabling access to new food resources (e.g. animal protein) in a changing environment. Recent experimental work provides strong evidence that both acute bouts of exercise and long-term exercise training increase the size of brain components and improve cognitive performance in humans and other taxa. However, to date, researchers have not explored the possibility that the increases in aerobic capacity and physical activity that occurred during human evolution directly influenced the human brain. Here, we hypothesize that proximate mechanisms linking physical activity and neurobiology in living species may help to explain changes in brain size and cognitive function during human evolution. We review evidence that selection acting on endurance increased baseline neurotrophin and growth factor signalling (compounds responsible for both brain growth and for metabolic regulation during exercise) in some mammals, which in turn led to increased overall brain growth and development. This hypothesis suggests that a significant portion of human neurobiology evolved due to selection acting on features unrelated to cognitive performance.

Mars Human Exploration Objectives

NASA Technical Reports Server (NTRS)

Briggs, Geoff

1998-01-01

This paper reviews the objectives and other considerations of Human exploration of Mars. The objectives of human exploration of Mars are: (1) to learn how Mars is similar to, and different from, Earth; (2) to explore possible life, past and present; (3) to discover what Mars is like now from the perspective of Geoscience and geologic history; and (4) how did Mars form and how did its formation differ from Earth. Considerations of human Martian exploration involve: (1) having a capable base laboratory; (2) having long range transportation; (3) having operational autonomy of the crew, and the requirement of the crew to possess a range of new cognitive processes along with easy communications with terrestrial colleagues; and finally (4) creating the human habitat along with human factors which involve more than just survivability.

Humans in Space: Summarizing the Medico-Biological Results of the Space Shuttle Program

NASA Technical Reports Server (NTRS)

Risin, Diana; Stepaniak, P. C.; Grounds, D. J.

2011-01-01

As we celebrate the 50th anniversary of Gagarin's flight that opened the era of Humans in Space we also commemorate the 30th anniversary of the Space Shuttle Program (SSP) which was triumphantly completed by the flight of STS-135 on July 21, 2011. These were great milestones in the history of Human Space Exploration. Many important questions regarding the ability of humans to adapt and function in space were answered for the past 50 years and many lessons have been learned. Significant contribution to answering these questions was made by the SSP. To ensure the availability of the Shuttle Program experiences to the international space community NASA has made a decision to summarize the medico-biological results of the SSP in a fundamental edition that is scheduled to be completed by the end of 2011 beginning 2012. The goal of this edition is to define the normal responses of the major physiological systems to short-duration space flights and provide a comprehensive source of information for planning, ensuring successful operational activities and for management of potential medical problems that might arise during future long-term space missions. The book includes the following sections: 1. History of Shuttle Biomedical Research and Operations; 2. Medical Operations Overview Systems, Monitoring, and Care; 3. Biomedical Research Overview; 4. System-specific Adaptations/Responses, Issues, and Countermeasures; 5. Multisystem Issues and Countermeasures. In addition, selected operational documents will be presented in the appendices. The chapters are written by well-recognized experts in appropriate fields, peer reviewed, and edited by physicians and scientists with extensive expertise in space medical operations and space-related biomedical research. As Space Exploration continues the major question whether humans are capable of adapting to long term presence and adequate functioning in space habitats remains to be answered We expect that the comprehensive review of the medico-biological results of the SSP along with the data collected during the missions on the space stations (Mir and ISS) provides a good starting point in seeking the answer to this question.

Design of human missions to Mars and robotic missions to Jupiter

NASA Astrophysics Data System (ADS)

Okutsu, Masataka

We consider human missions to Mars and robotic missions to Jupiter for launch dates in the near- and far-future. For the near-future, we design trajectories for currently proposed space missions that have well-defined spacecraft and mission requirements. For example, for early human missions to Mars we assume that the constraints used in NASA's design reference missions are indicative of current and near-future technologies, which of course limit our capabilities to explore Mars--and these limits make the problem challenging. Similarly, in the case of robotic exploration of Jupiter, we consider that the technology levels assumed for the proposed Europa Orbiter mission represent reasonable limits. For the far-future (two to three decades from now), we take the best estimates from current literature about the capabilities that may be available in nuclear-powered electric propulsion. We consider hardware capabilities (in terms of specific mass, specific impulse, thrust, power, etc.) for low-thrust trajectories, which range froth near-term to far-future technologies. In designing such missions, several techniques are found useful. For example, the Tisserand Graph, which tracks the changes in orbital shapes and energies, provides insight in designing Jovian tours for the Europa Orbiter mission. The graph is also useful in analyzing abort trajectories for human missions to Mars. Furthermore, a patched-conic propagator, which can generate thousands of potential trajectories, plays a vital role in three of four chapters of this thesis. For launches in the next three decades, we discovered a class of Earth- Mars-Venus-Earth free returns (which appear only four times in the 100-year period), Jovian tours involving ten to twenty flybys of the Galilean satellites, and low-thrust trajectories to Jupiter via gravity assists from Venus, Earth, and Mars. In addition, our continuation method, in which a solution for a conic trajectory is gradually converted into that for a low- thrust trajectory, is found effective in design of some families of low-thrust trajectories. The method is applied, for example, in the design of a "one- vehicle cycler," an architecture requiring only one interplanetary vehicle for sustained human missions to Mars.

A multimodal MRI dataset of professional chess players.

PubMed

Li, Kaiming; Jiang, Jing; Qiu, Lihua; Yang, Xun; Huang, Xiaoqi; Lui, Su; Gong, Qiyong

2015-01-01

Chess is a good model to study high-level human brain functions such as spatial cognition, memory, planning, learning and problem solving. Recent studies have demonstrated that non-invasive MRI techniques are valuable for researchers to investigate the underlying neural mechanism of playing chess. For professional chess players (e.g., chess grand masters and masters or GM/Ms), what are the structural and functional alterations due to long-term professional practice, and how these alterations relate to behavior, are largely veiled. Here, we report a multimodal MRI dataset from 29 professional Chinese chess players (most of whom are GM/Ms), and 29 age matched novices. We hope that this dataset will provide researchers with new materials to further explore high-level human brain functions.

Departure Energies, Trip Times and Entry Speeds for Human Mars Missions

NASA Technical Reports Server (NTRS)

Munk, Michelle M.

1999-01-01

The study examines how the mission design variables departure energy, entry speed, and trip time vary for round-trip conjunction-class Mars missions. These three parameters must be balanced in order to produce a mission that is acceptable in terms of mass, cost, and risk. For the analysis, a simple, massless- planet trajectory program was employed. The premise of this work is that if the trans-Mars and trans-Earth injection stages are designed for the most stringent opportunity in the energy cycle, then there is extra energy capability in the "easier" opportunities which can be used to decrease the planetary entry speed, or shorten the trip time. Both of these effects are desirable for a human exploration program.

Departure Energies, Trip Times and Entry Speeds for Human Mars Missions

NASA Technical Reports Server (NTRS)

Munk, Michelle M.

1999-01-01

The study examines how the mission design variables departure energy, entry speed, and trip time vary for round-trip conjunction-class Mars missions. These three parameters must be balanced in order to produce a mission that is acceptable in terms of mass, cost, and risk. For the analysis, a simple, massless-planet trajectory program was employed. The premise of this work is that if the trans-Mars and trans-Earth injection stages are designed for the most stringent opportunity in the energy cycle, then there is extra energy capability in the "easier" opportunities which can be used to decrease the planetary entry speed, or shorten the trip time. Both of these effects are desirable for a human exploration program.

Human dignity and professional reputation under threat: Iranian Nurses' experiences of workplace violence.

PubMed

Najafi, Fereshteh; Fallahi-Khoshknab, Masoud; Ahmadi, Fazlollah; Dalvandi, Asghar; Rahgozar, Mehdi

2017-03-01

Workplace violence against nurses is a challenging problem in both developed and developing countries. Because the concept of violence bears some cultural load, nurses' understanding is region-specific. This study explores Iranian nurses' perceptions of workplace violence. Using qualitative content analysis, 22 registered nurses underwent unstructured, in-depth interviews. The main themes of threats to human dignity and professional reputation emerged, plus four categories: physical violence, psychological violence, honor insults, and ethnic-religious insults. The term "honor insults," as a unique finding, was used instead of "sexual harassment." These findings may help to redefine workplace violence based on cultural background, design strategies for supporting nurses, and prevent and manage such violence. © 2016 John Wiley & Sons Australia, Ltd.

Leadership and America's future in space

NASA Technical Reports Server (NTRS)

Ride, Sally K.

1987-01-01

In response to growing concern over the posture and long-term direction of the U.S. civilian space program, a task group was formed to define potential U.S. space initiatives, and to evaluate them in light of the current space program and the nation's desire to regain and retain space leadership. The objectives were to energize a discussion of the long-term goals of the civilian space program and to begin to investigate overall strategies to direct that program to a position of leadership. Four initiatives were identified: mission to planet Earth; exploration of the solar system; outpost on the Moon, and humans to Mars. All four initiatives were developed in detail, and the implications and requirements of each was assessed. The long-term goals, current posturing required to attain these goals, and the need for a continuing process to define, refine, and assess both the goals and the strategy to achieve them are discussed.

Beyond Earth's boundaries: Human exploration of the Solar System in the 21st Century

NASA Technical Reports Server (NTRS)

1991-01-01

This is an annual report describing work accomplished in developing the knowledge base that will permit informed recommendations and decisions concerning national space policy and the goal of human expansion into the solar system. The following topics are presented: (1) pathways to human exploration; (2) human exploration case studies; (3) case study results and assessment; (4) exploration program implementation strategy; (5) approach to international cooperation; (6) recommendations; and (7) future horizons.

Lunar Extravehicular Activity Program

NASA Technical Reports Server (NTRS)

Heartsill, Amy Ellison

2006-01-01

Extravehicular Activity (EVA) has proven an invaluable tool for space exploration since the inception of the space program. There are situations in which the best means to evaluate, observe, explore and potentially troubleshoot space systems are accomplished by direct human intervention. EVA provides this unique capability. There are many aspects of the technology required to enable a "miniature spaceship" to support individuals in a hostile environment in order to accomplish these tasks. This includes not only the space suit assembly itself, but the tools, design interfaces of equipment on which EVA must work and the specific vehicles required to support transfer of humans between habitation areas and the external world. This lunar mission program will require EVA support in three primary areas. The first of these areas include Orbital stage EVA or micro-gravity EVA which includes both Low Earth Orbit (LEO), transfer and Lunar Orbit EVA. The second area is Lunar Lander EVA capability, which is lunar surface EVA and carries slightly different requirements from micro-gravity EVA. The third and final area is Lunar Habitat based surface EVA, which is the final system supporting a long-term presence on the moon.

Plasma Oscillation Characterization of NASA's HERMeS Hall Thruster via High Speed Imaging

NASA Technical Reports Server (NTRS)

Huang, Wensheng; Kamhawi, Hani; Haag, Thomas W.

2016-01-01

For missions beyond low Earth orbit, spacecraft size and mass can be dominated by onboard chemical propulsion systems and propellants that may constitute more than 50 percent of the spacecraft mass. This impact can be substantially reduced through the utilization of Solar Electric Propulsion (SEP) due to its substantially higher specific impulse. Studies performed for NASA's Human Exploration and Operations Mission Directorate and Science Mission Directorate have demonstrated that a 50kW-class SEP capability can be enabling for both near term and future architectures and science missions. A high-power SEP element is integral to the Evolvable Mars Campaign, which presents an approach to establish an affordable evolutionary human exploration architecture. To enable SEP missions at the power levels required for these applications, an in-space demonstration of an operational 50kW-class SEP spacecraft has been proposed as a SEP Technology Demonstration Mission (TDM). In 2010 NASA's Space Technology Mission Directorate (STMD) began developing high-power electric propulsion technologies. The maturation of these critical technologies has made mission concepts utilizing high-power SEP viable.

NASA Advisory Council: Fact-Finding Session

NASA Technical Reports Server (NTRS)

Cohen, Aaron; Martin, Franklin D.; Craig, Mark K.; Duke, Michael B.

1992-01-01

The principal agenda item for this fact-finding meeting of the NASA Advisory Council was NASA's preliminary planning of options to implement the President's initiative for establishing a base on the Moon and launching a human expedition to Mars. NASA's presentation (1) reviewed the key elements in the President's speech of July 20, 1989, summoning the Nation to launch a new exploration initiative to the Moon and Mars; (2) outlined five candidate options analyzed in terms of schedule and scale of effort (for a return to the Moon and for a voyage to Mars); (3) outlined tentative robotic mission milestones for both a 'vigorous deployment' option and a 'paced deployment' option; (4) reviewed Earth-to-orbit delivery requirements for a lunar heavy-lift launch vehicle, the National Space Transportation System, and a Mars heavy-lift launch vehicle; (5) summarized the associated Space Station Freedom requirements; (6) outlined the technology as well as human factors requirements for the candidate options; and (7) summarized the themes and approaches that could be employed for the science aspects of a national Moon/Mars exploration program.

An information and dialogue conference on the human genome project (HGP) for the minority communities in the state of Louisiana

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1999-06-01

Zeta Phi Beta Sorority National Educational Foundation, in cooperation with Xavier University of New Orleans, and the New Orleans District Office of the United States Equal Employment Opportunity Commission, held the Information and Dialogue Conference on the Human Genome Project for the Minority Communities in the State of Louisiana on April 16-17, 1999. The Conference was held on the campus of Xavier University in New Orleans. Community leaders, government officials, minority professional and social organizations leaders, religious leaders, persons from the educational and academic community, and students were invited. Conference objectives included bringing HGP information and a focus in themore » minority community on the project, in clear and understandable terms, to spread the work in the minority community about the project; to explore the likely positive implications with respect to health care and related matters; to explore possible negative results and strategies to meet them; to discuss the social, legal, and ethical implications; and to facilitate minority input into the HGP as it develops.« less

The Importance of Conducting Life Sciences Experiments on the Deep Space Gateway Platform

NASA Technical Reports Server (NTRS)

Bhattacharya, S.

2018-01-01

Over the last several decades important information has been gathered by conducting life science experiments on the Space Shuttle and on the International Space Station. It is now time to leverage that scientific knowledge, as well as aspects of the hardware that have been developed to support the biological model systems, to NASA's next frontier - the Deep Space Gateway. In order to facilitate long duration deep space exploration for humans, it is critical for NASA to understand the effects of long duration, low dose, deep space radiation on biological systems. While carefully controlled ground experiments on Earth-based radiation facilities have provided valuable preliminary information, we still have a significant knowledge gap on the biological responses of organisms to chronic low doses of the highly ionizing particles encountered beyond low Earth orbit. Furthermore, the combined effects of altered gravity and radiation have the potential to cause greater biological changes than either of these parameters alone. Therefore a thorough investigation of the biological effects of a cis-lunar environment will facilitate long term human exploration of deep space.

Allocation of Functions in a Far-Term Air Traffic Control Environment

NASA Technical Reports Server (NTRS)

Homola, Jeffrey; Martin, Lynne; Mercer, Joey; Cabrall, Christopher; Prevot, Thomas

2011-01-01

A human-in-the-loop exploration of a ground-based automated separation assurance concept was conducted that involved the allocation of certain functions between humans and automation. This exploration included operations that were sustained for prolonged periods of time with high levels of traffic in the presence of convective weather and scheduling constraints. An investigation into the acceptability of the defined roles and performance of tasks was conducted where it was found that the participants rated the concept and allocation of functions with a high level of acceptability. However, issues were encountered with the automation related to the detection of and response to tactical conflicts. Lower ratings were given on account of these concerns, and it was found that a key contributor to the underlying problems was transitioning aircraft and the uncertainty of their trajectories. Stemming from those results, participants responded that they would rather have direct control over aircraft transitions as well as more control over the tactical conflict resolution automation. In contrast, participants responded that they would rather have the automation place aircraft back on trajectory, and perform weather avoidance and scheduling tasks.

Pax permanent Martian base: Space architecture for the first human habitation on Mars, volume 5

NASA Technical Reports Server (NTRS)

Huebner-Moths, Janis; Fieber, Joseph P.; Rebholz, Patrick J.; Paruleski, Kerry L.; Moore, Gary T. (Editor)

1992-01-01

America at the Threshold: Report of the Synthesis Group on America's Space Exploration Initiative (the 'Synthesis Report,' sometimes called the Stafford Report after its astronaut chair, published in 1991) recommended that NASA explore what it called four 'architectures,' i.e., four different scenarios for habitation on Mars. The Advanced Design Program in Space Architecture at the University of Wisconsin-Milwaukee supported this report and two of its scenarios--'Architecture 1' and 'Architecture 4'--during the spring of 1992. This report investigates the implications of different mission scenarios, the Martian environment, supporting technologies, and especially human factors and environment-behavior considerations for the design of the first permanent Martian base. The report is comprised of sections on mission analysis, implications of the Martian atmosphere and geologic environment, development of habitability design requirements based on environment-behavior and human factors research, and a full design proposed (concept design and design development) for the first permanent Martian base and habitat. The design is presented in terms of a base site plan, master plan based on a Mars direct scenario phased through IOC, and design development details of a complete Martian habitat for 18 crew members including all laboratory, mission control, and crew support spaces.

The immunotherapy of canine osteosarcoma: a historical and systematic review.

PubMed

Wycislo, K L; Fan, T M

2015-01-01

Osteosarcoma is a malignant mesenchymal neoplasm that accounts for the majority of primary bone tumors in dogs and shares biological and clinical similarities with osteosarcoma in humans. Despite dose intensification with conventional cytotoxic therapies, survival times for dogs and humans diagnosed with high-grade osteosarcoma have not changed in the past 20 years, with the principal cause of mortality being the development of pulmonary metastases. Given the therapeutic plateau reached for delaying metastatic progression with cytotoxic agents, exploration of alterative adjuvant therapies for improving management of osteosarcoma micrometastases is clinically justified. Evidence suggests that osteosarcoma is an immunogenic tumor, and development of immunotherapies for the treatment of microscopic lung metastases might improve long-term outcomes. In this review, the history and foundational knowledge of immune interactions to canine osteosarcoma are highlighted. In parallel, immunotherapeutic strategies that have been explored for the treatment of canine osteosarcoma are summarized. With a greater understanding and awareness for how the immune system might be redirected toward combating osteosarcoma metastases, the rational development of diverse immune strategies for managing osteosarcoma holds substantial promise for transforming the therapeutic landscape and improving disease management in both dogs and human beings. Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.

Oxygenation-linked subunit interactions in human hemoglobin: analysis of linkage functions for constituent energy terms.

PubMed

Johnson, M L; Halvorson, H R; Ackers, G K

1976-11-30

Resolution of the linkage functions between oxygenation and subunit association-dissociation equilibria in human hemoglobin into the constituent microscopic terms has been explored by numerical simulation and least-squares analysis. The correlation properties between parameters has been studied using several choices of parameter sets in order to optimize resolution. It is found that, with currently available levels of experimental precision and ranges of variables, neither linkage function can provide sufficient resolution of all the desired energy terms. The most difficult quantities to resolve always include the dimer-tetramer association constant for unliganded hemoglobin and the oxygen binding constants to alphabeta dimers. A feasible experimental strategy for overcoming these difficulties lies in independent determination of the dimer-tetramer association constants for unliganded and fully oxygenated hemoglobin. These constants, in combination with the median lignad concentration, provide an estimate of the energy for total oxygenation of tetramers which is essentially independent of the other constituent energies. It is shown that if these separately determinable parameters are fixed, the remaining terms may be estimated to good accuracy using data which represents either linkage function. In general it is desirable to combine information from both types of experimental quantities. A previous paper (Mills, F.C., Johnson, M.L., and Ackers, G.K. (1976), Biochemestry, 15, the preceding paper in this issue) describes the experimental implementation of this strategy.

Geological Disposal of Radioactive Waste: A Long-Term Socio-Technical Experiment.

PubMed

Schröder, Jantine

2016-06-01

In this article we investigate whether long-term radioactive waste management by means of geological disposal can be understood as a social experiment. Geological disposal is a rather particular technology in the way it deals with the analytical and ethical complexities implied by the idea of technological innovation as social experimentation, because it is presented as a technology that ultimately functions without human involvement. We argue that, even when the long term function of the 'social' is foreseen to be restricted to safeguarding the functioning of the 'technical', geological disposal is still a social experiment. In order to better understand this argument and explore how it could be addressed, we elaborate the idea of social experimentation with the notion of co-production and the analytical tools of delegation, prescription and network as developed by actor-network theory. In doing so we emphasize that geological disposal inherently involves relations between surface and subsurface, between humans and nonhumans, between the social, material and natural realm, and that these relations require recognition and further elaboration. In other words, we argue that geological disposal concurrently is a social and a technical experiment, or better, a long-term socio-technical experiment. We end with proposing the idea of 'actor-networking' as a sensitizing concept for future research into what geological disposal as a socio-technical experiment could look like.

Lunar base as a precursor to Mars exploration and settlement

NASA Technical Reports Server (NTRS)

Mendell, Wendell W.

1991-01-01

A well planned program of human exploration of the moon is suggested which would provide a base for increasing human capabilities and experience to levels required for Mars exploration. A strategy intended for immediate Mars exploration and settlement is considered to incur serious programmatic risks from current lack of knowledge on human performance on long-duration deep space missions and lack of experience in designing human space systems. The lunar program provides an opportunity to build up space capability in an evolutionary way and to broaden the participation of the educational system in the space exploration.

Human Exploration on the Moon, Mars and NEOs: PEX.2/ICEUM12B

NASA Astrophysics Data System (ADS)

Foing, Bernard H.

2016-07-01

The session COSPAR-16-PEX.2: "Human Exploration on the Moon, Mars and NEOs", co-sponsored by Commissions B, F will include solicited and contributed talks and poster/interactive presentations. It will also be part of the 12th International Conference on Exploration and Utilisation of the Moon ICEUM12B from the ILEWG ICEUM series started in 1994. It will address various themes and COSPAR communities: - Sciences (of, on, from) the Moon enabled by humans - Research from cislunar and libration points - From robotic villages to international lunar bases - Research from Mars & NEOs outposts - Humans to Phobos/Deimos, Mars and NEOS - Challenges and preparatory technologies, field research operations - Human and robotic partnerships and precursor missions - Resource utilisation, life support and sustainable exploration - Stakeholders for human exploration One half-day session will be dedicated to a workshop format and meetings/reports of task groups: Science, Technology, Agencies, Robotic village, Human bases, Society & Commerce, Outreach, Young Explorers. COSPAR has provided through Commissions, Panels and Working Groups (such as ILEWG, IMEWG) an international forum for supporting and promoting the robotic and human exploration of the Moon, Mars and NEOS. Proposed sponsors : ILEWG, ISECG, IKI, ESA, NASA, DLR, CNES, ASI, UKSA, JAXA, ISRO, SRON, CNSA, SSERVI, IAF, IAA, Lockheed Martin, Google Lunar X prize, UNOOSA

Enhanced hepatic differentiation of human amniotic epithelial cells on polyethylene glycol-linked multiwalled carbon nanotube-coated hydrogels.

PubMed

Zhao, Chunyan; Lin, Jamie Siqi; Choolani, Mahesh; Dan, Yock Young; Pastorin, Giorgia; Ho, Han Kiat

2018-04-26

Polyethylene glycol-linked multiwalled carbon nanotube-coated poly-acrylamide hydrogel (CNT-PA) was customized to mimic human liver stiffness and nanostructured surface in liver cells for modulating differentiation of human amniotic epithelial cells (hAECs) into functional hepatocyte-like cells (HLCs) in vitro. This composite of CNT-PA matrix enhanced the hepatic differentiation of hAECs into HLCs with suppression of pluripotent markers and up-regulation of hepatic markers at both transcript and protein levels. Furthermore, the HLCs on CNT-PA demonstrated hepatocytic functions in terms of albumin secretion, higher uptake of indocyanine green, and comparable CYP3A4 enzymatic function and inducibility when matched against HepG2 cells. Taken together, CNT-PA provides an efficient and scalable platform for the expansion of HLCs from hAECs and could be explored further for downstream development. Copyright © 2018 John Wiley & Sons, Ltd.

Conservation and restoration of mangroves: Global status, perspectives, and prognosis

USGS Publications Warehouse

Romañach, Stephanie; DeAngelis, Donald L.; Koh, Hock Lye; Li, Yuhong; Teh, Su Yean; Barizan, Raja Sulaiman Raja; Zhai, Lu

2018-01-01

Mangrove forests provide critical services around the globe to both human populations and the ecosystems they occupy. However, losses of mangrove habitat of more than 50% have been recorded in some parts of the world, and these losses are largely attributable to human activities. The importance of mangroves and the threats to their persistence have long been recognized, leading to actions taken locally, by national governments, and through international agreements for their protection. In this review, we explore the status of mangrove forests as well as efforts to protect them. We examine threats to the persistence of mangroves, consequences, and potential solutions for effective conservation. We present case studies from disparate regions of the world, showing that the integration of human livelihood needs in a manner that balances conservation goals can present solutions that could lead to long-term sustainability of mangrove forests throughout the world.

Clinical Application of Induced Pluripotent Stem Cells in Cardiovascular Medicine.

PubMed

Chi, Hong-jie; Gao, Song; Yang, Xin-chun; Cai, Jun; Zhao, Wen-shu; Sun, Hao; Geng, Yong-Jian

2015-01-01

Induced pluripotent stem cells (iPSCs) are generated by reprogramming human somatic cells through the overexpression of four transcription factors: Oct4, Sox2, Klf4 and c-Myc. iPSCs are capable of indefinite self-renewal, and they can differentiate into almost any type of cell in the body. These cells therefore offer a highly valuable therapeutic strategy for tissue repair and regeneration. Recent experimental and preclinical research has revealed their potential for cardiovascular disease diagnosis, drug screening and cellular replacement therapy. Nevertheless, significant challenges remain in terms of the development and clinical application of human iPSCs. Here, we review current progress in research related to patient-specific iPSCs for ex vivo modeling of cardiovascular disorders and drug screening, and explore the potential of human iPSCs for use in the field of cardiovascular regenerative medicine. © 2015 S. Karger AG, Basel.

Biomarkers of human cardiopulmonary response after short-term exposures to medical laser generated particulate matter from simulated procedures: a pilot study

PubMed Central

Lopez, Ramon; Farber, Mark O.; Wong, Vincent; Lacey, Steven E.

2016-01-01

Objective We conducted an exposure chamber study in humans using a simulated clinical procedure lasing porcine tissue to demonstrate evidence of effects of exposure to laser generated particulate matter (LGPM). Methods We measured pre- and post-exposure changes in exhaled nitric oxide (eNO), spirometry, heart rate variability (HRV), and blood markers of inflammation in five volunteers. Results Change in pre- and post-exposure measurements of eNO and spirometry were unremarkable. Neutrophil and lymphocyte counts increased and fibrinogen levels decreased in four of the five subjects. Measures of HRV showed decreases in the standard deviation of normal between beat intervals and sequential five-minute intervals. Conclusion These data represent the first evidence of human physiologic response to LGPM exposure. Further exploration of coagulation effects and HRV are warranted. PMID:27465102

Securitization, alterity, and the state Human (in)security on an Amazonian frontier

PubMed Central

Brightman, Marc; Grotti, Vanessa

2016-01-01

Focusing on the region surrounding the Maroni River, which forms the border between Suriname and French Guiana, we examine how relations between different state and non-state social groups are articulated in terms of security. The region is characterised by multiple “borders” and frontiers of various kinds, the state boundary having the features of an interface or contact zone. Several key collectivities meet in this border zone: native Amazonians, tribal Maroon peoples, migrant Brazilian gold prospectors, and metropolitan French state functionaries. We explore the relationships between these different sets of actors and describe how their mutual encounters center on discourses of human and state security, thus challenging the commonly held view of the region as a stateless zone and showing that the “human security” of citizens from the perspective of the state may compete with locally salient ideas or experiences of well-being. PMID:27996063

Bioethics and the Right to Health: Advancing a Complementary Agenda.

PubMed

Gibson, Jennifer L; Forman, Lisa; Nixon, Stephanie A

2015-06-11

This special section in Health and Human Rights Journal explores the relationship between bioethics and the right to health. Although bioethics scholars may argue for a right to health, particularly in the domains of universal health coverage and global health governance, and human rights scholars may advance ethical norms in their work, there has been little scholarly attention to the intersections, synergies, and contrasts between these two areas of study. At first glance, this is surprising given that bioethics and human rights share conceptual and normative terrain in articulating guidance for action on health-related issues and international policy and practice is explicitly interrelating human rights and ethics. Copyright 2015 Gibson, Forman, Nixon. This is an open access article distributed under the terms of Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licences/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original authors and source are credited.

Workload-Matched Adaptive Automation Support of Air Traffic Controller Information Processing Stages

NASA Technical Reports Server (NTRS)

Kaber, David B.; Prinzel, Lawrence J., III; Wright, Melanie C.; Clamann, Michael P.

2002-01-01

Adaptive automation (AA) has been explored as a solution to the problems associated with human-automation interaction in supervisory control environments. However, research has focused on the performance effects of dynamic control allocations of early stage sensory and information acquisition functions. The present research compares the effects of AA to the entire range of information processing stages of human operators, such as air traffic controllers. The results provide evidence that the effectiveness of AA is dependent on the stage of task performance (human-machine system information processing) that is flexibly automated. The results suggest that humans are better able to adapt to AA when applied to lower-level sensory and psychomotor functions, such as information acquisition and action implementation, as compared to AA applied to cognitive (analysis and decision-making) tasks. The results also provide support for the use of AA, as compared to completely manual control. These results are discussed in terms of implications for AA design for aviation.

Matrix Metalloproteinase-3 (MMP-3) Is an Endogenous Activator of the MMP-9 Secreted by Placental Leukocytes: Implication in Human Labor.

PubMed

Flores-Pliego, Arturo; Espejel-Nuñez, Aurora; Castillo-Castrejon, Marisol; Meraz-Cruz, Noemi; Beltran-Montoya, Jorge; Zaga-Clavellina, Veronica; Nava-Salazar, Sonia; Sanchez-Martinez, Maribel; Vadillo-Ortega, Felipe; Estrada-Gutierrez, Guadalupe

2015-01-01

The activity of matrix degrading enzymes plays a leading role in the rupture of the fetal membranes under normal and pathological human labor, and matrix metalloproteinase-9 (MMP-9) it is considered a biomarker of this event. To gain further insight into local MMP-9 origin and activation, in this study we analyzed the contribution of human placental leukocytes to MMP-9 secretion and explored the local mechanisms of the pro-enzyme activation. Placental blood leukocytes were obtained from women at term gestation without labor and maintained in culture up to 72 h. MMP-9 activity in the culture supernatants was determined by zymography and using a specific substrate. The presence of a potential pro-MMP-9 activator in the culture supernatants was monitored using a recombinant biotin-labeled human pro-MMP-9. To characterize the endogenous pro-MMP-9 activator, MMP-1, -3, -7 and -9 were measured by multiplex assay in the supernatants, and an inhibition assay of MMP-9 activation was performed using an anti-human MMP-3 and a specific MMP-3 inhibitor. Finally, production of MMP-9 and MMP-3 in placental leukocytes obtained from term pregnancies with and without labor was assessed by immunofluorescence. Placental leukocytes spontaneously secreted pro-MMP-9 after 24 h of culture, increasing significantly at 48 h (P≤0.05), when the active form of MMP-9 was detected. Culture supernatants activated the recombinant pro-MMP-9 showing that placental leukocytes secrete the activator. A significant increase in MMP-3 secretion by placental leukocytes was observed since 48 h in culture (P≤0.05) and up to 72 h (P≤0.001), when concentration reached its maximum value. Specific activity of MMP-9 decreased significantly (P≤0.005) when an anti-MMP-3 antibody or a specific MMP-3 inhibitor were added to the culture media. Placental leukocytes from term labor produced more MMP-9 and MMP-3 compared to term non-labor cells. In this work we confirm that placental leukocytes from human term pregnancies are able to secrete large amounts of MMP-9, and that the production of the enzyme it is enhanced by labor. We also demonstrate for the first time that endogenous MMP-3 plays a major role in MMP-9 activation process. These findings support the contribution of placental leukocytes to create the collagenolytic microenvironment that induces the rupture of the fetal membranes during human labor.

Cognitive science and the cultural nature of music.

PubMed

Cross, Ian

2012-10-01

The vast majority of experimental studies of music to date have explored music in terms of the processes involved in the perception and cognition of complex sonic patterns that can elicit emotion. This paper argues that this conception of music is at odds both with recent Western musical scholarship and with ethnomusicological models, and that it presents a partial and culture-specific representation of what may be a generic human capacity. It argues that the cognitive sciences must actively engage with the problems of exploring music as manifested and conceived in the broad spectrum of world cultures, not only to elucidate the diversity of music in mind but also to identify potential commonalities that could illuminate the relationships between music and other domains of thought and behavior. Copyright © 2012 Cognitive Science Society, Inc.

Lunar exploration and the advancement of biomedical research: a physiologist's view.

PubMed

Piantadosi, Claude A

2006-10-01

Over the next few years, it will become apparent just how important lunar exploration is to biomedical research and vice versa, and how critical both are to the future of human spaceflight. NASA's Project Constellation should put a new lunar-capable vehicle into service by 2014 that will rely on proven Space Shuttle components and allow four astronauts to spend 7 d on the lunar surface. A modern space transportation system opens up a unique opportunity in the space sciences--the establishment of a permanent lunar laboratory for the physical and life sciences. This commentary presents a rationale for focusing American efforts in space on such a Moon base in order to promote understanding of the long-term physiological effects of living on a planetary body outside the Van Allen belts.

The Net Present Value and Other Economic Implications of a Medical Career.

PubMed

Reinhardt, Uwe E

2017-07-01

College graduates' career choices are driven by a complex mixture of factors, one of which is economics. The author comments on the report by Marcu and colleagues in this issue, which focuses strictly on the economics of this decision. Specifically, Marcu and colleagues modeled career choices as long-term financial investments in human capital, which consists of the knowledge and clinical skills physicians gain in undergraduate and graduate medical education. They distill the numerous factors that shape the economics of career choice into a commonly used criterion for long-term financial investments of any kind-namely, the so-called net present value (NPV) of the investment. For them, that investment is the decision to pursue a medical career rather than the next best nonmedical, alternative career. This NPV calculation determines the increase or decrease in wealth, relative to that of the next best alternative career, that a college graduate is thought to experience as of the moment she or he enters medical school simply by choosing a medical career rather than the next best alternative. Marcu and colleagues use this human capital model to explore how different plans to finance a medical school education impact the NPV, all other parameters being equal. The author of this Commentary explains in layman's terms how the NPV is calculated and then raises a number of other issues concerning the economics of a medical career, including medical school tuition, residents' salaries, and investments in human capital as tax deductible.

Relational and Transcendental Humanism: Exploring the Consequences of a Thoroughly Pragmatic Humanism

ERIC Educational Resources Information Center

Hansen, James T.

2007-01-01

The relational and transcendental elements of humanism are considered. Although the relational component of humanism is extraordinarily valuable, the author argues that the transcendental portion of humanism should be abandoned. The implications of a thoroughly pragmatic humanism are explored.

Lunar exploration: opening a window into the history and evolution of the inner Solar System

PubMed Central

Crawford, Ian A.; Joy, Katherine H.

2014-01-01

The lunar geological record contains a rich archive of the history of the inner Solar System, including information relevant to understanding the origin and evolution of the Earth–Moon system, the geological evolution of rocky planets, and our local cosmic environment. This paper provides a brief review of lunar exploration to-date and describes how future exploration initiatives will further advance our understanding of the origin and evolution of the Moon, the Earth–Moon system and of the Solar System more generally. It is concluded that further advances will require the placing of new scientific instruments on, and the return of additional samples from, the lunar surface. Some of these scientific objectives can be achieved robotically, for example by in situ geochemical and geophysical measurements and through carefully targeted sample return missions. However, in the longer term, we argue that lunar science would greatly benefit from renewed human operations on the surface of the Moon, such as would be facilitated by implementing the recently proposed Global Exploration Roadmap. PMID:25114318

Hands-Free Control Interfaces for an Extra Vehicular Jetpack

NASA Technical Reports Server (NTRS)

Zumbado, Jennifer Rochlis; Curiel, Pedro H.; Schreiner, Sam

2012-01-01

The National Aeronautics and Space Administration (NASA) strategic vision includes, as part of its long-term goals, the exploration of deep space and Near Earth Asteroids (NEA). To support these endeavors, funds have been invested in research to develop advanced exploration capabilities. To enable the human mobility necessary to effectively explore NEA and deep space, a new extravehicular activity (EVA) Jetpack is under development at the Johnson Space Center. The new design leverages knowledge and experience gained from the current astronaut rescue device, the Simplified Aid for EVA Rescue (SAFER). Whereas the primary goal for a rescue device is to return the crew to a safe haven, in-space exploration and navigation requires an expanded set of capabilities. To accommodate the range of tasks astronauts may be expected to perform while utilizing the Jetpack, it was desired to offer a hands-free method of control. This paper describes the development and innovations involved in creating two hands-free control interfaces and an experimental test platform for a suited astronaut flying the Jetpack during an EVA.