Autonomous biological system-an unique method of conducting long duration space flight experiments for pharmaceutical and gravitational biology research

NASA Astrophysics Data System (ADS)

Anderson, G. A.; MacCallum, T. K.; Poynter, J. E.; Klaus, D., Dr.

1998-01-01

Paragon Space Development Corporation (SDC) has developed an Autonomous Biological System (ABS) that can be flown in space to provide for long term growth and breeding of aquatic plants, animals, microbes and algae. The system functions autonomously and in isolation from the spacecraft life support systems and with no mandatory crew time required for function or observation. The ABS can also be used for long term plant and animal life support and breeding on a free flyer space craft. The ABS units are a research tool for both pharmaceutical and basic space biological sciences. Development flights in May of 1996 and September, 1996 through January, 1997 were largely successful, showing both that the hardware and life systems are performing with beneficial results, though some surprises were still found. The two space flights, plus the current flight now on Mir, are expected to result in both a scientific and commercially usable system for breeding and propagation of animals and plants in space.

Cultivation in Space Flight Produces Minimal Alterations in the Susceptibility of Bacillus subtilis Cells to 72 Different Antibiotics and Growth-Inhibiting Compounds

PubMed Central

Morrison, Michael D.; Fajardo-Cavazos, Patricia

2017-01-01

ABSTRACT Past results have suggested that bacterial antibiotic susceptibility is altered during space flight. To test this notion, Bacillus subtilis cells were cultivated in matched hardware, medium, and environmental conditions either in space flight microgravity on the International Space Station, termed flight (FL) samples, or at Earth-normal gravity, termed ground control (GC) samples. The susceptibility of FL and GC samples was compared to 72 antibiotics and growth-inhibitory compounds using the Omnilog phenotype microarray (PM) system. Only 9 compounds were identified by PM screening as exhibiting significant differences (P < 0.05, Student's t test) in FL versus GC samples: 6-mercaptopurine, cesium chloride, enoxacin, lomefloxacin, manganese(II) chloride, nalidixic acid, penimepicycline, rolitetracycline, and trifluoperazine. Testing of the same compounds by standard broth dilution assay did not reveal statistically significant differences in the 50% inhibitory concentrations (IC50s) between FL and GC samples. The results indicate that the susceptibility of B. subtilis cells to a wide range of antibiotics and growth inhibitors is not dramatically altered by space flight. IMPORTANCE This study addresses a major concern of mission planners for human space flight, that bacteria accompanying astronauts on long-duration missions might develop a higher level of resistance to antibiotics due to exposure to the space flight environment. The results of this study do not support that notion. PMID:28821547

Locomotor function after long-duration space flight: effects and motor learning during recovery.

PubMed

Mulavara, Ajitkumar P; Feiveson, Alan H; Fiedler, James; Cohen, Helen; Peters, Brian T; Miller, Chris; Brady, Rachel; Bloomberg, Jacob J

2010-05-01

Astronauts returning from space flight and performing Earth-bound activities must rapidly transition from the microgravity-adapted sensorimotor state to that of Earth's gravity. The goal of the current study was to assess locomotor dysfunction and recovery of function after long-duration space flight using a test of functional mobility. Eighteen International Space Station crewmembers experiencing an average flight duration of 185 days performed the functional mobility test (FMT) pre-flight and post-flight. To perform the FMT, subjects walked at a self selected pace through an obstacle course consisting of several pylons and obstacles set up on a base of 10-cm-thick, medium-density foam for a total of six trials per test session. The primary outcome measure was the time to complete the course (TCC, in seconds). To assess the long-term recovery trend of locomotor function after return from space flight, a multilevel exponential recovery model was fitted to the log-transformed TCC data. All crewmembers exhibited altered locomotor function after space flight, with a median 48% increase in the TCC. From the fitted model we calculated that a typical subject would recover to 95% of his/her pre-flight level at approximately 15 days post-flight. In addition, to assess the early motor learning responses after returning from space flight, we modeled performance over the six trials during the first post-flight session by a similar multilevel exponential relation. We found a significant positive correlation between measures of long-term recovery and early motor learning (P < 0.001) obtained from the respective models. We concluded that two types of recovery processes influence an astronaut's ability to re-adapt to Earth's gravity environment. Early motor learning helps astronauts make rapid modifications in their motor control strategies during the first hours after landing. Further, this early motor learning appears to reinforce the adaptive realignment, facilitating re-adaptation to Earth's 1-g environment on return from space flight.

Qualification and Lessons Learned with Space Flight Fiber Optic Components

NASA Technical Reports Server (NTRS)

Ott, Melanie

2007-01-01

This presentation covers lessons learned during the design, development, manufacturing and qualification of space flight fiber optic components. Changes at NASA, including short-term projects and decreased budgets have brought about changes to vendors and parts. Most photonics for NASA needs are now commercial off the shelf (COTS) products. The COTS Tecnology Assurance approach for space flight and qualification plans are outlined.

Effects of Space Flight on Ovarian-Hypophyseal Function in Postpartum Rats

NASA Technical Reports Server (NTRS)

Burden, H. W.; Zary, J.; Lawrence, I. E.; Jonnalagadda, P.; Davis, M.; Hodson, C. A.

1997-01-01

The effect of space flight in a National Aeronautics and Space Administration (NASA) shuttle was studied in pregnant rats. Rats were launched on day 9 of gestation and recovered on day 20 of gestation. On day 20 of gestation, rats were unilaterally hysterectomized and subsequently allowed to go to term and deliver vaginally. There was no effect of space flight on pituitary and ovary mass postpartum. In addition, space flight did not alter healthy and atretic ovarian antral follicle populations, fetal wastage in utero, plasma concentrations of progesterone and luteinizing hormone (LH) or pituitary content of follicle stimulating hormone (FSH). Space flight significantly increased plasma concentrations of FSH and decreased pituitary content of LH at the postpartum sampling time. Collectively, these data show that space flight, initiated during the postimplantation period of pregnancy, and concluded before parturition, is compatible with maintenance of pregnancy and has minimal effects on postpartum hypophyseal parameters; however, none of the ovarian parameters examined was altered by space flight.

Human physiological adaptation to extended Space Flight and its implications for Space Station

NASA Technical Reports Server (NTRS)

Kutyna, F. A.; Shumate, W. H.

1985-01-01

Current work evaluating short-term space flight physiological data on the homeostatic changes due to weightlessness is presented as a means of anticipating Space Station long-term effects. An integrated systems analysis of current data shows a vestibulo-sensory adaptation within days; a loss of body mass, fluids, and electrolytes, stabilizing in a month; and a loss in red cell mass over a month. But bone demineralization which did not level off is seen as the biggest concern. Computer algorithms have been developed to simulate the human adaptation to weightlessness. So far these paradigms have been backed up by flight data and it is hoped that they will provide valuable information for future Space Station design. A series of explanatory schematics is attached.

Assessment of Nutrient Stability in Space Foods

NASA Technical Reports Server (NTRS)

Zwart, S. R.; Perchonok, M.; Braby, L. A.; Kloeris, V. A.; Smith, S. M.

2009-01-01

Maintaining an intact nutrient supply in the food system flown on spacecraft is a critical issue for mission success and crew health and safety. Early polar expeditions and exploration expeditions by sailing vessels have taught us that a deficiency, or excess, of even a single vitamin in the food supply can be catastrophic. Evidence from ground-based research indicates that some vitamins are destroyed and fatty acids are oxidized (and therefore rendered dangerous or useless) by different types of radiation and by conditions of long-term storage. We hypothesize that radiation and long-term storage in the space-flight environment will affect the stability of vitamins, amino acids, and fatty acids in the space food system. The research objectives of our ongoing stability studies are to determine the stability of water- and fat-soluble vitamins, fatty acids, and amino acids in the space food supply before and after space flight on the International Space Station (ISS). Foods were analyzed after 2 weeks (a flight control), 11, 19, and 28 months of flight. Along with the space-flown foods, ground-based controls matched for time, light, and temperature are analyzed. The flight studies complement planned ground-based studies of the effects of radiation on vitamins, amino acids, and fatty acids. Flight studies are needed because a model based on ground-based data cannot predict all of the effects of the space-flight environment. Flight studies provide a more accurate test system to determine the effects on these nutrients of the temperature, and radiation conditions in the space-flight environment. Ground studies are required to evaluate longer missions and higher radiation levels expected outside low-Earth orbit. In addition to providing information about nutrient stability in space, the results of these studies will help NASA determine if a need exists to develop special packaging that can ensure stability of foods and nutrients in space, or if further studies of nutrient metabolism or nutrient requirements are needed.

Role of muscle spindle in weightlessness-induced amyotrophia and muscle pain.

PubMed

Ali, Umar; Fan, Xiao-Li; You, Hao-Jun

2009-10-01

To date, the medium and long-term space flight is urgent in need and has become a major task of our manned space flight program. There is no doubt that medium and long-term space flight has serious damaging impact upon human physiological systems. For instance, atrophy of the lower limb anti-gravity muscle can be induced during the space flight. Muscle atrophy significantly affects the flight of astronauts in space. Most importantly, it influences the precise manipulation of the astronauts and their response capacity to emergencies on returning to the atmosphere from space. Muscle atrophy caused by weightlessness may also seriously disrupt the normal life and work of the astronauts during the re-adaptation period. Here we summarize the corresponding research concentrating on weightlessness-induced changes of muscular structure and function. By combining research on muscle pain, which is a common clinical pain disease, we further provide a hypothesis concerning a dynamic feedback model of "weightlessness condition right triple arrow muscular atrophy <--> muscle pain". This may be useful to explore the neural mechanisms underlying the occurrence and development of muscular atrophy and muscle pain, through the key study of muscle spindle, and furthermore provide more effective therapy for clinical treatment.

Space Flight-Associated Neuro-ocular Syndrome.

PubMed

Lee, Andrew G; Mader, Thomas H; Gibson, C Robert; Tarver, William

2017-09-01

New and unique physiologic and pathologic systemic and neuro-ocular responses have been documented in astronauts during and after long-duration space flight. Although the precise cause remains unknown, space flight-associated neuro-ocular syndrome (SANS) has been adopted as an appropriate descriptive term. The Space Medicine Operations Division of the US National Aeronautics and Space Administration (NASA) has documented the variable occurrence of SANS in astronauts returning from long-duration space flight on the International Space Station. These clinical findings have included unilateral and bilateral optic disc edema, globe flattening, choroidal and retinal folds, hyperopic refractive error shifts, and nerve fiber layer infarcts. The clinical findings of SANS have been correlated with structural changes on intraorbital and intracranial magnetic resonance imaging and in-flight and terrestrial ultrasonographic studies and ocular optical coherence tomography. Further study of SANS is ongoing for consideration of future manned missions to space, including a return trip to the moon or Mars.

Approach to an Affordable and Productive Space Transportation System

NASA Technical Reports Server (NTRS)

McCleskey, Carey M.; Rhodes, Russel E.; Lepsch, Roger A.; Henderson, Edward M.; Robinson, John W.

2012-01-01

This paper describes an approach for creating space transportation architectures that are affordable, productive, and sustainable. The architectural scope includes both flight and ground system elements, and focuses on their compatibility to achieve a technical solution that is operationally productive, and also affordable throughout its life cycle. Previous papers by the authors and other members of the Space Propulsion Synergy Team (SPST) focused on space flight system engineering methods, along with operationally efficient propulsion system concepts and technologies. This paper follows up previous work by using a structured process to derive examples of conceptual architectures that integrate a number of advanced concepts and technologies. The examples are not intended to provide a near-term alternative architecture to displace current near-term design and development activity. Rather, the examples demonstrate an approach that promotes early investments in advanced system concept studies and trades (flight and ground), as well as in advanced technologies with the goal of enabling highly affordable, productive flight and ground space transportation systems.

Evaluation of NASA Foodbars as a Standard Diet for Use in Short-Term Rodent Space Flight Studies

NASA Technical Reports Server (NTRS)

Tou, Janet; Grindeland, Richard; Barrett, Joyce; Dalton, Bonnie; Mandel, Adrian; Wade, Charles

2003-01-01

A standard rodent diet for space flight must meet the unique conditions imposed by the space environment and must be nutritionally adequate since diet can influence the outcome of experiments. This paper evaluates the use of National Aeronautics and Space Administration (NASA) developed Foodbars as a standard space flight diet for rats. The Foodbar's semi-purified formulation permits criteria such as nutrient consistency, high nutrient bioavailability and flexibility of formulation to be met. Extrusion of the semi-purified diet produces Foodbars with the proper texture and a non-crumbing solid form for use in space. Treatment of Foodbar with 0.1% potassium sorbate prevents mold growth. Irradiation (15-25 kGy) prevents bacterial growth and in combination with sorbate-treatment provides added protection against mold for shelf-stability. However, during the development process, nutrient analyses indicated that extrusion and irradiation produced nutrient losses. Nutrients were adjusted accordingly to compensate for processing losses. Nutrient analysis of Foodbars continues to be performed routinely to monitor nutrient levels. It is important that the standard rodent diet provide nutrients that will prevent deficiency but also avoid excess that may mask physiological changes produced by space flight. All vitamins levels in the Foodbars, except for vitamin K conformed to or exceeded the current NRC (1995) recommendations. All indispensable amino acids in Foodbar conformed to or exceeded the NRC nutrient recommendation for mice growth and rat maintenance. However, some indispensable amino acids were slightly below recommendations for rat reproduction/growth. Short-term (18-20 d) animal feeding studies indicated that Foodbars were palatable, supported growth and maintained health in rats. Results indicated that NASA rodent Foodbars meet both the physical and nutritional criteria required to support rodents in the space environment and thus, may be used successfully as a standard diet for short-term space flight studies. However, nutritional adequacy of NASA Rodent Foodbars as a standard diet on longer duration (>20 d) space flight missions remains to be determined.

USSR Report, Space, No. 19.

DTIC Science & Technology

1983-01-31

Descriptors USSR Space Exploration Space Technology 9. identifiers/Open-£nded Terms e. cosATi Reid/ Grouo 03, 22, 17A, 17B, 17C, 17E...Jul 82) 21 Ryumin Interviewed on Work of Cosmonauts, Flight Controllers (R. Kornaushenko; OGONEK, 2 Oct 82) 23 Chronology of ’Salyut-7’ Flight...reported from Flight Control Center: "The Facets of Cooperation"] [Excerpt] "Turn on computer memory prior to beginning the ’Diffuziya’ [Diffusion

Low Gravity Issues of Deep Space Refueling

NASA Technical Reports Server (NTRS)

Chato, David J.

2005-01-01

This paper discusses the technologies required to develop deep space refueling of cryogenic propellants and low cost flight experiments to develop them. Key technologies include long term storage, pressure control, mass gauging, liquid acquisition, and fluid transfer. Prior flight experiments used to mature technologies are discussed. A plan is presented to systematically study the deep space refueling problem and devise low-cost experiments to further mature technologies and prepare for full scale flight demonstrations.

Marshall Space Flight Center CFD overview

NASA Technical Reports Server (NTRS)

Schutzenhofer, Luke A.

1989-01-01

Computational Fluid Dynamics (CFD) activities at Marshall Space Flight Center (MSFC) have been focused on hardware specific and research applications with strong emphasis upon benchmark validation. The purpose here is to provide insight into the MSFC CFD related goals, objectives, current hardware related CFD activities, propulsion CFD research efforts and validation program, future near-term CFD hardware related programs, and CFD expectations. The current hardware programs where CFD has been successfully applied are the Space Shuttle Main Engines (SSME), Alternate Turbopump Development (ATD), and Aeroassist Flight Experiment (AFE). For the future near-term CFD hardware related activities, plans are being developed that address the implementation of CFD into the early design stages of the Space Transportation Main Engine (STME), Space Transportation Booster Engine (STBE), and the Environmental Control and Life Support System (ECLSS) for the Space Station. Finally, CFD expectations in the design environment will be delineated.

Comparison of ground-based and space flight energy expenditure and water turnover in middle-aged healthy male US astronauts

NASA Technical Reports Server (NTRS)

Lane, H. W.; Gretebeck, R. J.; Schoeller, D. A.; Davis-Street, J.; Socki, R. A.; Gibson, E. K.

1997-01-01

Energy requirements during space flight are poorly defined because they depend on metabolic-balance studies, food disappearance, and dietary records. Water turnover has been estimated by balance methods only. The purpose of this study was to determine energy requirements and water turnover for short-term space flights (8-14 d). Subjects were 13 male astronauts aged 36-51 y with normal body mass indexes (BMIs). Total energy expenditure (TEE) was determined during both a ground-based period and space flight and compared with the World Health Organization (WHO) calculations of energy requirements and dietary intake. TEE was not different for the ground-based and the space-flight periods (12.40 +/- 2.83 and 11.70 +/- 1.89 MJ/d, respectively), and the WHO calculation using the moderate activity correction was a good predictor of TEE during space flight. During the ground-based period, energy intake and TEE did not differ, but during space flight energy intake was significantly lower than TEE; body weight was also less at landing than before flight. Water turnover was lower during space flight than during the ground-based period (2.7 +/- 0.6 compared with 3.8 +/- 0.5 L/d), probably because of lower fluid intakes and perspiration loss during flight. This study confirmed that the WHO calculation can be used for male crew members' energy requirements during short space flights.

Bone Density Following Three Years of Recovery from Long-Duration Space Flight

NASA Technical Reports Server (NTRS)

Amin, Shreyasee; Achenbach, Sara J.; Atkinson, Elizabeth J.; Sibonga, Jean

2011-01-01

It is well recognized that bone mineral density [BMD] at load-bearing sites of the hip and spine sustain significant loss during space flight, estimated at approximately 0.5-1.0% per month. However, the long-term effects on bone health following return from long-duration space flight remain unclear. It is unknown whether BMD for men recovers beyond 1 year following return from space to what would be predicted or if deficits persist. Using our previously created prediction models, we compared the observed BMD of male US crew following 3 years since returning from longduration space flight with what would be predicted if they had not been exposed to microgravity.

Effects of Space Flight on Rodent Tissues

NASA Technical Reports Server (NTRS)

Worgul, Basil V.

1997-01-01

As the inevitable expression of mankind's search for knowledge continues into space, the potential acute and long-term effects of space flight on human health must be fully appreciated. Despite its critical role relatively little is known regarding the effects of the space environment on the ocular system. Our proposed studies were aimed at determining whether or not space flight causes discernible disruption of the genomic integrity, cell kinetics, cytoarchitecture and other cytological parameters in the eye. Because of its defined and singular biology our main focus was on the lens and possible changes associated with its primary pathology, cataract. We also hoped to explore the possible effect of space flight on the preferred orientation of dividing cells in the perilimbal region of conjunctiva and cornea.

International and NASA SSA and Safety of Flight Issues

NASA Technical Reports Server (NTRS)

Johnson, Nicholas K,

2010-01-01

This presentation reviews the international and NASA interests in Space Situational Awareness (SSA) and space debris as it affects space flight safety. The international interesrt has increased since the collision of the Iridium and Cosmos satellites in 2009. The United Nations Committee on the Peaceful Uses of Outer Space (UN COPUOS) has commenced a multi-year effort to review the long-term sustainability of outer space activities.

Glossary of software engineering laboratory terms

NASA Technical Reports Server (NTRS)

1982-01-01

A glossary of terms used in the Software Engineering Laboratory (SEL) is presented. The terms are defined within the context of the software development environment for flight dynamics at Goddard Space Flight Center. A concise reference for clarifying and understanding the language employed in SEL documents and data collection forms is provided.

Body Fluid Regulation and Hemopoiesis in Space Flight

NASA Technical Reports Server (NTRS)

1997-01-01

In this session, Session JA2, the discussion focuses on the following topics: Bodymass and Fluid Distribution During Longterm Spaceflight with and without Countermeasures; Plasma Volume, Extracellular Fluid Volume, and Regulatory Hormones During Long-Term Space Flight; Effect of Microgravity and its Ground-Based Models on Fluid Volumes and Hemocirculatory Volumes; Seventeen Weeks of Horizontal Bed Rest, Lower Body Negative Pressure Testing, and the Associated Plasma Volume Response; Evaporative Waterloss in Space Theoretical and Experimental Studies; Erythropoietin Under Real and Simulated Micro-G Conditions in Humans; and Vertebral Bone Marrow Changes Following Space Flight.

Sustaining Human Space Flight: From the Present to the Future

NASA Technical Reports Server (NTRS)

Russell, Rick

2010-01-01

This slide presentation reviews some of the efforts to ensure that human space flight continues in NASA. With the aging shuttle orbiter fleet, some actions have been taken to assure safe operations. Some of these are: (1) the formation of a Corrosion Control Review Board (CCRB) that will assess the extent and cause of corrosion to the shuttle, and provide short term and long term corrective actions, among other objectives, (2) a formalization of an aging vehicle assessment (AVA) as part of a certification for the Return-to-Flight, (3) an assessment of the age life of the materials in the space shuttle, and (4) the formation of the Aging Orbiter Working Group (AOWG). There are also slides with information about the International Space Station. There is also information about the need to update the Kennedy Space Center, to sustain a 21st century launch complex and the requirement to further the aim of commercial launch capability.

Pancreas of C57 black mice after long-term space flight (Bion-M1 Space Mission).

PubMed

Proshchina, A E; Krivova, Y S; Saveliev, S C

2015-11-01

In this study, we analysed the pancreases of C57BL/6N mice in order to estimate the effects of long-term space flights. Mice were flown aboard the Bion-M1 biosatellite, or remained on ground in the control experiment that replicated environmental and housing conditions in the spacecraft. Vivarium control group was used to account for housing effects. Each of the groups included mice designated for recovery studies. Mice pancreases were dissected for histological and immunohistochemical examinations. Using a morphometry and statistical analysis, a strong correlation between the mean islet size and the mean body weight was revealed in all groups. Therefore, we propose that hypokinesia and an increase in nutrition play an important role in alterations of the endocrine pancreas, both in space flight and terrestrial conditions. Copyright © 2015 The Committee on Space Research (COSPAR). Published by Elsevier Ltd. All rights reserved.

[A portable impedance meter for monitoring liquid compartments of human body under space flight conditions].

PubMed

Noskov, V B; Nikolaev, D V; Tuĭkin, S A; Kozharinov, V I; Grachev, V A

2007-01-01

A portable two-frequency tetrapolar impedance meter was developed to study the state of liquid compartments of human body under zero-gravity conditions. The portable impedance meter makes it possible to monitor the hydration state of human body under conditions of long-term space flight on board international space station.

Discovery.

ERIC Educational Resources Information Center

Smithsonian Institution, Washington, DC. National Air And Space Museum.

This material presents the historical perspectives of flight and student activities for grades K-3 prepared by the National Air and Space Museum (NASM) and National Aeronautics and Space Administration (NASA). Sections included are: (1) "Historical Perspective of Flight"; (2) "Discovery Vocabulary" (listing the terms found in the first section);…

Workshop on Exercise Prescription for Long-Duration Space Flight

NASA Technical Reports Server (NTRS)

Harris, Bernard A., Jr. (Editor); Stewart, Donald F. (Editor)

1989-01-01

The National Aeronautics and Space Administration has a dedicated history of ensuring human safety and productivity in flight. Working and living in space long term represents the challenge of the future. Our concern is in determining the effects on the human body of living in space. Space flight provides a powerful stimulus for adaptation, such as cardiovascular and musculoskeletal deconditioning. Extended-duration space flight will influence a great many systems in the human body. We must understand the process by which this adaptation occurs. The NASA is agressively involved in developing programs which will act as a foundation for this new field of space medicine. The hallmark of these programs deals with prevention of deconditioning, currently referred to as countermeasures to zero g. Exercise appears to be most effective in preventing the cardiovascular and musculoskeletal degradation of microgravity.

Pancreas of C57 black mice after long-term space flight (Bion-M1 Space Mission)

NASA Astrophysics Data System (ADS)

Proshchina, A. E.; Krivova, Y. S.; Saveliev, S. C.

2015-11-01

In this study, we analysed the pancreases of C57BL/6N mice in order to estimate the effects of long-term space flights. Mice were flown aboard the Bion-M1 biosatellite, or remained on ground in the control experiment that replicated environmental and housing conditions in the spacecraft. Vivarium control group was used to account for housing effects. Each of the groups included mice designated for recovery studies. Mice pancreases were dissected for histological and immunohistochemical examinations. Using a morphometry and statistical analysis, a strong correlation between the mean islet size and the mean body weight was revealed in all groups. Therefore, we propose that hypokinesia and an increase in nutrition play an important role in alterations of the endocrine pancreas, both in space flight and terrestrial conditions.

[Kidney stone formation during space flight and long-term bed rest].

PubMed

Okada, Atsushi; Ichikawa, Jun; Tozawa, Keiichi

2011-10-01

Microgravity environment like space flight or a condition requiring long-term bed-rest increase bone resorption and decrease bone formation, inducing the rapid decrease of bone minerals to osteoporosis. Bone mineral loss increases urinary calcium excretion and the risk of urinary stone formation. To clarify the influence of the conditions on renal stone formation, a 90-day bed rest test was performed to analyze the mechanism of microgravity or bed rest-induced stone formation and prevention by bisphosphonate medication and bed-rest exercise. As the results, renal stone formation was observed in control and exercise groups and no stone was seen in the medication group. In the medication group, urinary calcium excretion and relative supersaturation of calcium oxalate were lower than in the control group throughout the bed-rest and recovery period. Bisphosphonate is useful for the prevention of renal stone formation during space flight and long-term bed-rest.

14 CFR 437.89 - Pre-flight reporting.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Pre-flight reporting. 437.89 Section 437.89... TRANSPORTATION LICENSING EXPERIMENTAL PERMITS Terms and Conditions of an Experimental Permit § 437.89 Pre-flight reporting. (a) Not later than 30 days before each flight or series of flights conducted under an...

14 CFR 437.89 - Pre-flight reporting.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Pre-flight reporting. 437.89 Section 437.89... TRANSPORTATION LICENSING EXPERIMENTAL PERMITS Terms and Conditions of an Experimental Permit § 437.89 Pre-flight reporting. (a) Not later than 30 days before each flight or series of flights conducted under an...

14 CFR 437.89 - Pre-flight reporting.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Pre-flight reporting. 437.89 Section 437.89... TRANSPORTATION LICENSING EXPERIMENTAL PERMITS Terms and Conditions of an Experimental Permit § 437.89 Pre-flight reporting. (a) Not later than 30 days before each flight or series of flights conducted under an...

14 CFR 437.89 - Pre-flight reporting.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Pre-flight reporting. 437.89 Section 437.89... TRANSPORTATION LICENSING EXPERIMENTAL PERMITS Terms and Conditions of an Experimental Permit § 437.89 Pre-flight reporting. (a) Not later than 30 days before each flight or series of flights conducted under an...

Simulation of physiological systems in order to evaluate and predict the human condition in a space flight

NASA Technical Reports Server (NTRS)

Verigo, V. V.

1979-01-01

Simulation models were used to study theoretical problems of space biology and medicine. The reaction and adaptation of the main physiological systems to the complex effects of space flight were investigated. Mathematical models were discussed in terms of their significance in the selection of the structure and design of biological life support systems.

Immune function during space flight

NASA Technical Reports Server (NTRS)

Sonnenfeld, Gerald; Shearer, William T.

2002-01-01

It is very likely that the human immune system will be altered in astronauts exposed to the conditions of long-term space flight: isolation, containment, microgravity, radiation, microbial contamination, sleep disruption, and insufficient nutrition. In human and animal subjects flown in space, there is evidence of immune compromise, reactivation of latent virus infection, and possible development of a premalignant or malignant condition. Moreover, in ground-based space flight model investigations, there is evidence of immune compromise and reactivation of latent virus infection. All of these observations in space flight itself or in ground-based models of space flight have a strong resonance in a wealth of human pathologic conditions involving the immune system where reactivated virus infections and cancer appear as natural consequences. The clinical conditions of Epstein-Barr-driven lymphomas in transplant patients and Kaposi's sarcoma in patients with autoimmune deficiency virus come easily to mind in trying to identify these conditions. With these thoughts in mind, it is highly appropriate, indeed imperative, that careful investigations of human immunity, infection, and cancer be made by space flight researchers.

Esrange Space Center, a Gate to Space

NASA Astrophysics Data System (ADS)

Widell, Ola

Swedish Space Corporation (SSC) is operating the Esrange Space Center in northern Sweden. Space operations have been performed for more than 40 years. We have a unique combination of maintaining balloon and rocket launch operations, and building payloads, providing space vehicles and service systems. Sub-orbital rocket flights with land recovery and short to long duration balloon flights up to weeks are offered. The geographical location, land recovery area and the long term experience makes Swedish Space Corporation and Esrange to an ideal gate for space activities. Stratospheric balloons are primarily used in supporting atmospheric research, validation of satellites and testing of space systems. Balloon operations have been carried out at Esrange since 1974. A large number of balloon flights are yearly launched in cooperation with CNES, France. Since 2005 NASA/CSBF and Esrange provide long duration balloon flights to North America. Flight durations up to 5 days with giant balloons (1.2 Million cubic metres) carrying heavy payload (up to 2500kg) with astronomical instruments has been performed. Balloons are also used as a crane for lifting space vehicles or parachute systems to be dropped and tested from high altitude. Many scientific groups both in US, Europe and Japan have indicated a great need of long duration balloon flights. Esrange will perform a technical polar circum balloon flight during the summer 2008 testing balloon systems and flight technique. We are also working on a permission giving us the opportunity on a circular stratospheric balloon flight around the North Pole.

Evaluation of NASA Foodbars as a standard diet for use in short-term rodent space flight studies.

PubMed

Tou, Janet; Grindeland, Richard; Barrett, Joyce; Dalton, Bonnie; Mandel, Adrian; Wade, Charles

2003-01-01

[corrected] A standard rodent diet for space flight must meet the unique conditions imposed by the space environment and must be nutritionally adequate because diet can influence the outcome of experiments. We evaluated the use of National Aeronautics and Space Administration (NASA) Foodbars as a standard space flight diet for rats. The Foodbar's semi-purified formulation permitted criteria such as nutrient consistency, high nutrient bioavailability, and flexibility of formulation to be met. Extrusion of the semi-purified diet produced Foodbars with the proper texture and a non-crumbing solid form for use in space. Treatment of Foodbar with 0.1% potassium sorbate prevented mold growth. Irradiation (15 to 25 kGy) prevented bacterial growth and, in combination with sorbate treatment, added protection against mold for shelf stability. During the development process, nutrient analyses indicated that extrusion and irradiation produces nutrient losses. Nutrients were adjusted accordingly to compensate for processing losses. Nutrient analysis of Foodbars continues to be performed routinely to monitor nutrient levels. It is important that the standard rodent diet provide nutrients that will prevent deficiency but also avoid excess that may mask physiologic changes produced by space flight. All vitamin levels in the Foodbars, except for vitamin K, conformed to or exceeded the current National Research Council (NRC) 1995 recommendations. All indispensable amino acids in Foodbar conformed to or exceeded the NRC nutrient recommendation for mouse growth and rat maintenance. However, some indispensable amino acids were slightly below recommendations for rat reproduction and growth. Short-term (18 to 20 d) animal feeding studies indicated that Foodbars are palatable, support growth, and maintain health in rats. Results indicated that NASA Rodent Foodbars meet the physical and nutritional criteria required to support rodents in the space environment and thus may be used successfully as a standard diet for short-term space flight studies. However, the nutritional adequacy of NASA Rodent Foodbars as a standard diet on longer-duration (>20 d) space flight missions remains to be determined.

Activity of the sympathoadrenal system in cosmonauts during 25-day space flight on station Mir

NASA Astrophysics Data System (ADS)

Kvetňanský, R.; Noskov, V. B.; Blazicek, P.; Gharib, C.; Popova, I. A.; Gauquelin, G.; Macho, L.; Guell, A.; Grigoriev, A. I.

The activity of the sympathoadrenal system in cosmonauts was studied by measuring plasma and urinary catecholamines and their metabolites and conjugates. The appliance Plasma 02 was used for collecting, processing, and storing blood and urine samples from the cosmonauts during the course of a 25-day flight on board the station Mir. Plasma and urine concentrations of adrenaline (A), noradrenaline (NA), and dopamine (DA) as well as urinary levels of vanillylmandelic acid (VMA) and homovanillic acid (HVA), and plasma levels of catecholamine sulphates were determined before, during and after the space flight. Plasma NA levels were slightly elevated on day 9 and plasma A on day 20, whereas plasma DA levels were unchanged. However, most of the changes were within the normal range of control values. Sulphates of plasma catecholamines did not change during flight but they were significantly elevated after landing. Urinary levels of A, NA, DA, VMA, and HVA were comparable with preflight values but were elevated at the different intervals studied after landing. The results obtained suggest that in the short period of about 9 days of the cosmonaut's stay in space the sympathoadrenal system was slightly activated indicating a mild stressful influence of the initial period of flight. This short-term space flight compared to long-term flight did not as markedly activate the sympathoadrenal system during the process of re-adaptation to Earth's gravity after landing. Our data suggest that weightlessness is not a stressful factor activating the sympathoadrenal system but it sensitizes the responsiveness of this system during the re-adaptation period after space flight.

Soviet space flight: the human element.

PubMed

Garshnek, V

1988-05-01

Building on past experience and knowledge, the Soviet manned space flight effort has become broad, comprehensive, and forward-looking. Their long-running space station program has provided the capabilities to investigate long-term effects of microgravity on human physiology and behavior and test various countermeasures against microgravity-induced physiological deconditioning. Since the beginning of Soviet manned space flight, the biomedical training and preparation of cosmonauts has evolved from a process that increased human tolerance to space flight factors, to a system of interrelated measures to prepare cosmonauts physically and psychologically to live and work in space. Currently, the Soviet Union is constructing a multimodular space station, the Mir. With the emergence of dedicated laboratory modules, the Soviets have begun the transition from small-scale experimental research to large-scale production activities and specialized scientific work in space. In the future, additional laboratory modules will be added, including one dedicated to biomedical research, called the "Medilab." The longest manned space flight to date (326 days) has been completed by the Soviets. The biomedical effects of previous long-duration flights, and perhaps those of still greater length, may contribute important insight ito the possibility of extended missions beyond Earth, such as a voyage to Mars.

STS-4 test mission simulates operational flight: President terms success golden spike in space

NASA Technical Reports Server (NTRS)

1982-01-01

The fourth Space Shuttle flight is summarized. STS certification as operational, applications experiments, experiments involving crew, the first Getaway Special, a lightning survey. Shuttle environment measurement, prelaunch rain and hail, loss of solid rocket boosters, and modification of the thermal test program are reviewed.

Skylab environmental and crew microbiology studies

NASA Technical Reports Server (NTRS)

Taylor, G. R.; Graves, R. C.; Brockett, R. M.; Ferguson, J. K.; Mieszkuc, B. J.

1977-01-01

Microbial flora samples were collected from crewmembers before, during, and after missions in order to obtain data on the microbial response to space flight environment. Data showed that, while gross contamination of the Skylab environment was demonstrated and there were several in-flight disease events, such events are not limiting hazards for long term manned space flights. Intercrew transfer of pathogens was demonstrated, but evidence of postflight microbial shock was not found.

SSME digital control design characteristics

NASA Technical Reports Server (NTRS)

Mitchell, W. T.; Searle, R. F.

1985-01-01

To protect against a latent programming error (software fault) existing in an untried branch combination that would render the space shuttle out of control in a critical flight phase, the Backup Flight System (BFS) was chartered to provide a safety alternative. The BFS is designed to operate in critical flight phases (ascent and descent) by monitoring the activities of the space shuttle flight subsystems that are under control of the primary flight software (PFS) (e.g., navigation, crew interface, propulsion), then, upon manual command by the flightcrew, to assume control of the space shuttle and deliver it to a noncritical flight condition (safe orbit or touchdown). The problems associated with the selection of the PFS/BFS system architecture, the internal BFS architecture, the fault tolerant software mechanisms, and the long term BFS utility are discussed.

Space medicine considerations: Skeletal and calcium homeostasis

NASA Technical Reports Server (NTRS)

Schneider, Victor B.

1989-01-01

Based on the information obtained from space missions, particularly Skylab and the longer Salyut missions, it is clear that bone and mineral metabolism is substantially altered during space flight. Calcium balance becomes increasingly more negative throughout the flight, and the bone mineral content of the os calcis declines. The major health hazards associated with skeletal changes include the signs and symptoms of hypercalcemia with rapid bone turnover, the risk of kidney stones because of hypercalciuria, the lengthy recovery of lost bone mass after flight, the possibility of irreversible bone loss (particularly the trabecular bone), the possible effects of metastated calcification in the soft tissues, and the possible increase in fracture potential. For these reasons, major efforts need to be directed toward elucidating the fundamental mechanisms by which bone is lost in space and developing more effective countermeasures to prevent both short-term and long-term complications.

[Protein turnover during and after extended space flight

NASA Technical Reports Server (NTRS)

Stein, T. P.; Larina, I. M.; Leskiv, M. J.; Schluter, M. D.

2000-01-01

A 15N-glycine tracer technique was used to study protein turnover in four Russian cosmonauts and two U.S. astronauts who had spent long time aboard the Russian orbital station MIR. As was shown, in space flight protein synthesis falls by 46% on the average, which substantially exceeds estimations made on the basis of data about bed-rested human subjects. Reduction in protein synthesis during space flight is connected with the negative energy balance; therefore, it appears imperative to keep balance between energy intake (foodstuffs) and expenditure by cosmonauts on long-term mission.

[Energy reactions in the skeletal muscles of rats after short-term space flight on Kosmos-1514].

PubMed

Mailian, E S; Chabdarova, R N; Korzun, E I

1988-01-01

Ten hours after the 5-day space flight on Cosmos-1514 rats were examined for oxidative phosphorylation in mitochondria isolated from the posterior femoral muscles as well as for Krebs cycle enzymes and glycolysis in the mitochondrial and cytoplasmic fractions of the muscles. The mitochondrial respiration rate in various metabolic states was similar in flight rats and vivarium controls. After flight calculated parameters of energy efficacy of respiration as well as activity of malate dehydrogenase, isocitrate dehydrogenase and total lactate dehydrogenase remained unchanged. Unlike the flight rats, the synchronous controls showed signs of the stress-reaction: uncoupling of oxidative phosphorylation and oxalacetate inhibition of succinate dehydrogenase. Comparison of these findings with those from prolonged space flights indicates that inhibition of oxidative metabolism and glycolysis in mixed muscles which was demonstrated in the 20-day space flight does not develop immediately after launch but occurs within the time interval between mission days 6 and 18.

Bone Density Following Long Duration Space Flight and Recovery

NASA Technical Reports Server (NTRS)

Amin, Shreyasee; Achenbach, Sara J.; Atkinson, Elizabeth J.; Melton, L. Joseph; Khosla, Sundeep; Sibonga, Jean

2010-01-01

At approx.12 months, Bone Mineral Density (BMD) at most sites in men remained lower than would be predicted, raising concerns for long-term bone health consequences following space flight. Additional analyses based on longer follow-up are being conducted. Although the N is too small for definitive conclusions, women had lower rates of loss at load-bearing sites of the hip and spine immediately post-flight relative to men and smaller differences between observed vs. predicted BMD at most sites, both immediately and 12 months post-flight, relative to men. The role of other exposures/risk factors need to be explored to further understand these possible gender differences in BMD loss and recovery following long-duration space flight.

Atmospheric reentry flight test of winged space vehicle

NASA Astrophysics Data System (ADS)

Inatani, Yoshifumi; Akiba, Ryojiro; Hinada, Motoki; Nagatomo, Makoto

A summary of the atmospheric reentry flight experiment of winged space vehicle is presented. The test was conducted and carried out by the Institute of Space and Astronautical Science (ISAS) in Feb. 1992 in Kagoshima Space Center. It is the first Japanese atmospheric reentry flight of the controlled lifting vehicle. A prime objective of the flight is to demonstrate a high speed atmospheric entry flight capability and high-angle-of-attack flight capability in terms of aerodynamics, flight dynamics and flight control of these kind of vehicles. The launch of the winged vehicle was made by balloon and solid propellant rocket booster which was also the first trial in Japan. The vehicle accomplishes the lfight from space-equivalent condition to the atmospheric flight condition where reaction control system (RCS) attitude stabilization and aerodynamic control was used, respectively. In the flight, the vehicle's attitude was measured by both an inertial measurement unit (IMU) and an air data sensor (ADS) which were employed into an auto-pilot flight control loop. After completion of the entry transient flight, the vehicle experienced unexpected instability during the atmospheric decelerating flight; however, it recovered the attitude orientation and completed the transonic flight after that. The latest analysis shows that it is due to the ADS measurement error and the flight control gain scheduling; what happened was all understood. Some details of the test and the brief summary of the current status of the post flight analysis are presented.

Mission Report: STS-4 Test Mission Simulates Operational Flight. President Terms Success Golden Spike in Space

NASA Technical Reports Server (NTRS)

1982-01-01

The fourth space shuttle flight is summarized. An onboard electrophoresis experiment is reviewed. Crew physiology, the first getaway special, a lightning survey, shuttle environment measurement, prelaunch weather conditions, loss of solid rocket boosters, modification of thermal test program, and other events are also reviewed.

Mouse infection models for space flight immunology

NASA Technical Reports Server (NTRS)

Chapes, Stephen Keith; Ganta, Roman Reddy; Chapers, S. K. (Principal Investigator)

2005-01-01

Several immunological processes can be affected by space flight. However, there is little evidence to suggest that flight-induced immunological deficits lead to illness. Therefore, one of our goals has been to define models to examine host resistance during space flight. Our working hypothesis is that space flight crews will come from a heterogeneous population; the immune response gene make-up will be quite varied. It is unknown how much the immune response gene variation contributes to the potential threat from infectious organisms, allergic responses or other long term health problems (e.g. cancer). This article details recent efforts of the Kansas State University gravitational immunology group to assess how population heterogeneity impacts host health, either in laboratory experimental situations and/or using the skeletal unloading model of space-flight stress. This paper details our use of several mouse strains with several different genotypes. In particular, mice with varying MHCII allotypes and mice on the C57BL background with different genetic defects have been particularly useful tools with which to study infections by Staphylococcus aureus, Salmonella typhimurium, Pasteurella pneumotropica and Ehrlichia chaffeensis. We propose that some of these experimental challenge models will be useful to assess the effects of space flight on host resistance to infection.

The dynamics of blood biochemical parameters in cosmonauts during long-term space flights

NASA Astrophysics Data System (ADS)

Markin, Andrei; Strogonova, Lubov; Balashov, Oleg; Polyakov, Valery; Tigner, Timoty

Most of the previously obtained data on cosmonauts' metabolic state concerned certain stages of the postflight period. In this connection, all conclusions, as to metabolism peculiarities during the space flight, were to a large extent probabilistic. The purpose of this work was study of metabolism characteristics in cosmonauts directly during long-term space flights. In the capillary blood samples taken from a finger, by "Reflotron IV" biochemical analyzer, "Boehringer Mannheim" GmbH, Germany, adapted to weightlessness environments, the activity of GOT, GPT, CK, gamma-GT, total and pancreatic amylase, as well as concentration of hemoglobin, glucose, total bilirubin, uric acid, urea, creatinine, total, HDL- and LDL cholesterol, triglycerides had been determined. HDL/LDL-cholesterol ratio also was computed. The crewmembers of 6 main missions to the "Mir" orbital station, a total of 17 cosmonauts, were examined. Biochemical tests were carryed out 30-60 days before lounch, and in the flights different stages between the 25-th and the 423-rd days of flights. In cosmonauts during space flight had been found tendency to increase, in compare with basal level, GOT, GPT, total amylase activity, glucose and total cholesterol concentration, and tendency to decrease of CK activity, hemoglobin, HDL-cholesterol concentration, and HDL/LDL — cholesterol ratio. Some definite trends in variations of other determined biochemical parameters had not been found. The same trends of mentioned biochemical parameters alterations observed in majority of tested cosmonauts, allows to suppose existence of connection between noted metabolic alterations with influence of space flight conditions upon cosmonaut's body. Variations of other studied blood biochemical parameters depends on, probably, pure individual causes.

Effects of space flight on the immunohistochemical demonstration of connexin 26 and connexin 43 in the postpartum uterus of rats

NASA Technical Reports Server (NTRS)

Burden, H. W.; Zary, J.; Alberts, J. R.

1999-01-01

The effect of space flight in a National Aeronautics and Space Administration shuttle was studied in pregnant rats. Rats were launched on day 11 of gestation and recovered on day 20 of gestation. Pregnancy was allowed to proceed to term and rats delivered vaginally on days 22-23, although flight animals required more labour contractions to complete the delivery process. Pups were placed with foster dams and connexin 26 and 43 were examined in the uterus of flight animals approximately 3 h after delivery. Space flight did not affect uterine connexin 26, localized primarily in epithelial cells of the endometrium, but decreased connexin 43, the major gap junction protein in the myometrium. It is suggested that decreased connexin 43 alters synchronization and coordination of labour contractions, resulting in a requirement for more contractions to complete the delivery process.

Thermal control surfaces experiment: Initial flight data analysis

NASA Technical Reports Server (NTRS)

Wilkes, Donald R.; Hummer, Leigh L.

1991-01-01

The behavior of materials in the space environment continues to be a limiting technology for spacecraft and experiments. The thermal control surfaces experiment (TCSE) aboard the Long Duration Exposure Facility (LDEF) is the most comprehensive experiment flown to study the effects of the space environment on thermal control surfaces. Selected thermal control surfaces were exposed to the LDEF orbital environment and the effects of this exposure were measured. The TCSE combined in-space orbital measurements with pre and post-flight analyses of flight materials to determine the effects of long term space exposure. The TCSE experiment objective, method, and measurements are described along with the results of the initial materials analysis. The TCSE flight system and its excellent performance on the LDEF mission is described. A few operational anomalies were encountered and are discussed.

Bone loss during long term space flight is prevented by the application of a short term impulsive mechanical stimulus

NASA Astrophysics Data System (ADS)

Goodship, A. E.; Cunningham, J. L.; Oganov, V.; Darling, J.; Miles, A. W.; Owen, G. W.

In long term space flight, the mechanical forces applied to the skeleton are substantially reduced and are altered in character. This reduced skeletal loading results in a reduction in bone mass. Exercise techmques currently used in space can maintain muscle mass but the mechanical stimulus provided by this exercise does not prevent bone loss. By applying an external impulsive load for a short period each day, which is intended to mimic the heel strike transient, to the lower limb of an astronaut during a long term space flight (5 months), this study tests the hypothesis that the bone cells can be activated by an appropriate external mechanical stimulus to maintain bone mass throughout prolonged periods of weightlessness. A mechanical loading device was developed to produce a loading of the os-calcis similar to that observed during the heel strike transient. The device is activated by the astronaut to provide a transient load to the heel of one leg whilst providing an equivalent exercising load to the other leg. During the EUROMIR95 mission on the MIR space station, an astronaut used this device for a short period daily throughout the duration of the mission. Pre- and post-flight measurements of bone mineral density (BMD) of the os-calcis and femoral neck of the astronaut were made to determine the efficacy of the device in preventing loss of bone mineral during the mission. On the os-calcis which received the mechanical stimulus, BMD was maintained throughout the period of the flight, while it was reduced by up to 7% on the os-calcis which received no stimulus. Post-flight, BMD in both the stimulated and non-stimulated os-calcis reduces, the extent of this reduction however is less in the stimulated os-calcis. For the femoral neck, the mechanical Stimulation does not produce a positive effect. On the os-calcis which received the mechanical stimulus, BMD was maintained throughout the period of the flight, while it was reduced by up to 7% on the os-calcis which received no stimulus. Post-flight, BMD in both the stimulated and non-stimulated os-calcis reduces, the extent of this reduction however is less in the stimulated os-calcis. For the femoral neck, the mechanical stimulation does not produce a positive effect.

The nutritional status of astronauts is altered after long-term space flight aboard the International Space Station

NASA Technical Reports Server (NTRS)

Smith, Scott M.; Zwart, Sara R.; Block, Gladys; Rice, Barbara L.; Davis-Street, Janis E.

2005-01-01

Defining optimal nutrient requirements is critical for ensuring crew health during long-duration space exploration missions. Data pertaining to such nutrient requirements are extremely limited. The primary goal of this study was to better understand nutritional changes that occur during long-duration space flight. We examined body composition, bone metabolism, hematology, general blood chemistry, and blood levels of selected vitamins and minerals in 11 astronauts before and after long-duration (128-195 d) space flight aboard the International Space Station. Dietary intake and limited biochemical measures were assessed during flight. Crew members consumed a mean of 80% of their recommended energy intake, and on landing day their body weight was less (P = 0.051) than before flight. Hematocrit, serum iron, ferritin saturation, and transferrin were decreased and serum ferritin was increased after flight (P < 0.05). The finding that other acute-phase proteins were unchanged after flight suggests that the changes in iron metabolism are not likely to be solely a result of an inflammatory response. Urinary 8-hydroxy-2'-deoxyguanosine concentration was greater and RBC superoxide dismutase was less after flight (P < 0.05), indicating increased oxidative damage. Despite vitamin D supplement use during flight, serum 25-hydroxycholecalciferol was decreased after flight (P < 0.01). Bone resorption was increased after flight, as indicated by several markers. Bone formation, assessed by several markers, did not consistently rise 1 d after landing. These data provide evidence that bone loss, compromised vitamin D status, and oxidative damage are among critical nutritional concerns for long-duration space travelers.

Long-term biological investigations in space.

PubMed

Lotz, R G; Fuchs, H; Bertsche, U

1975-01-01

Missions in space within the next two decades will be of longer duration than those carried out up to the present time, and the effects of such long-term flights on biological organisms are unknown. Results of biological experiments that have been performed to date cannot be extrapolated to results in future flights because of the unknown influence of adaptation over a long period of time. Prior experiments with Axolotl, fishes, and vertebrates by our research team (in part with sounding rockets) showed that these specimens did not appear to be suitable for long-term missions on which minimization of expense, technique, and energy is required. Subsequent investigations have shown the suitability of the leech (Hirudo medicinalis), which consumes blood of mammals up to ten times its own weight (1 g) and can live more than 2 years without further food supply. Emphasis in the experiments with Hirudo medicinalis is placed on metabolic rhythm and motility. Resorption and diffusion in tissue, development, and growth under long-term effects of cosmic proton radiation and zero-gravity are other focal points. The constancy of cellular life in the mature animals is a point in favor of these specimens. We have also taken into account the synergistic effects of the space environment on the problems just mentioned. The life-support system constructed for the leech has been tested successfully in four sounding rocket flights and, on that basis, has been prepared for a long-term mission. Long-term investigations out of the terrestrial biosphere will provide us with information concerning the degree of adaptation of certain physiological and biochemical functions and as to what extent biological readjustment or repair processes can occur under the specific stress conditions of space flight.

Glossary of Software Engineering Laboratory terms

NASA Technical Reports Server (NTRS)

1983-01-01

A glossary of terms used in the Software Engineering Laboratory (SEL) is given. The terms are defined within the context of the software development environment for flight dynamics at the Goddard Space Flight Center. A concise reference for clarifying the language employed in SEL documents and data collection forms is given. Basic software engineering concepts are explained and standard definitions for use by SEL personnel are established.

Inhabiting the solar system

NASA Astrophysics Data System (ADS)

Sherwood, Brent

2011-03-01

The new field of space architecture is introduced. Defined as the "theory and practice of designing and building inhabited environments in outer space," the field synthesizes human space flight systems engineering subjects with the long tradition of making environments that support human living, work, and aspiration. The scope of the field is outlined, and its three principal domains differentiated. The current state of the art is described in terms of executed projects. Foreseeable options for 21st century developments in human space flight provide a framework to tease out potential space architecture opportunities for the next century.

Man in space - The use of animal models

NASA Technical Reports Server (NTRS)

Ballard, Rodney W.; Souza, Kenneth A.

1991-01-01

The use of animal surrogates as experimental subjects in order to provide essential missing information on the effects of long-term spaceflights, to validate countermeasures, and to test medical treatment techniques is discussed. Research needs also include the definition of biomedical adaptations to flight, and the developments of standards for safe space missions to assure human health and productivity during and following flight. NASA research plans in this area are outlined. Over the next 40 years, NASA plans to concentrate on the use of rodents and nonhuman primates as the models of choice for various physiological responses observed in humans during extended stays in space. This research will include flights on the Space Shuttle, unmanned biosatellites, and the Space Station Freedom.

Human tolerance to space flight

NASA Technical Reports Server (NTRS)

Huntoon, C. L.

1989-01-01

Medical studies of astronauts and cosmonauts before, during, and after space missions have identified several effects of weightlessness and other factors that influence the ability of humans to tolerate space flight. Weightlessness effects include space motion sickness, cardiovascular abnormalities, reduction in immune system function, loss of red blood cells, loss of bone mass, and muscle atrophy. Extravehicular activity (EVA) increases the likelihood that decompression sickness may occur. Radiation also gives reason for concern about health of crewmembers, and psychological factors are important on long-term flights. Countermeasures that have been used include sensory preadaptation, prebreathing and use of various air mixtures for EVA, loading with water and electrolytes, exercise, use of pharmacological agents and special diets, and psychological support. It appears that humans can tolerate and recover satisfactorily from at least one year of space flight, but a number of conditions must be further ameliorated before long-duration missions can be considered routine.

Challenges in the 1990's for astronaut training simulators

NASA Technical Reports Server (NTRS)

Brown, Patrick M.; Hajare, Ankur R.; Stark, George E.

1990-01-01

New challenges for the simulation community at the Johnson Space Center both in near and long terms are considered. In the near term, the challenges of supporting an increasing flight rate, maintaining operations while replacing obsolete subsystems, and incorporating forthcoming changes to the Space Shuttle are discussed, and focus is placed on a change of forward flight-deck instruments from electro-mechanical devices to electronic displays. Training astronauts for complex concurrent missions involving multiple spacecraft and geographically dispersed ground facilities is considered to be foremost of the long-term challenges, in addition to the tasks of improving the simulator reliability and the operational efficiency of the facilities.

The Ruggedized STD Bus Microcomputer - A low cost computer suitable for Space Shuttle experiments

NASA Technical Reports Server (NTRS)

Budney, T. J.; Stone, R. W.

1982-01-01

Previous space flight computers have been costly in terms of both hardware and software. The Ruggedized STD Bus Microcomputer is based on the commercial Mostek/Pro-Log STD Bus. Ruggedized PC cards can be based on commercial cards from more than 60 manufacturers, reducing hardware cost and design time. Software costs are minimized by using standard 8-bit microprocessors and by debugging code using commercial versions of the ruggedized flight boards while the flight hardware is being fabricated.

A Technology Plan for Enabling Commercial Space Business

NASA Technical Reports Server (NTRS)

Lyles, Garry M.

1997-01-01

The National Aeronautics and Space Administration's (NASA) Advanced Space Transportation Program is a customer driven, focused technology program that supports the NASA Strategic Plan and considers future commercial space business projections. The initial cycle of the Advanced Space Transportation Program implementation planning was conducted from December 1995 through February 1996 and represented increased NASA emphasis on broad base technology development with the goal of dramatic reductions in the cost of space transportation. The second planning cycle, conducted in January and February 1997, updated the program implementation plan based on changes in the external environment, increased maturity of advanced concept studies, and current technology assessments. The program has taken a business-like approach to technology development with a balanced portfolio of near, medium, and long-term strategic targets. Strategic targets are influenced by Earth science, space science, and exploration objectives as well as commercial space markets. Commercial space markets include those that would be enhanced by lower cost transportation as well as potential markets resulting in major increases in space business induced by reductions in transportation cost. The program plan addresses earth-to-orbit space launch, earth orbit operations and deep space systems. It also addresses all critical transportation system elements; including structures, thermal protection systems, propulsion, avionics, and operations. As these technologies are matured, integrated technology flight experiments such as the X-33 and X-34 flight demonstrator programs support near-term (one to five years) development or operational decisions. The Advanced Space Transportation Program and the flight demonstrator programs combine business planning, ground-based technology demonstrations and flight demonstrations that will permit industry and NASA to commit to revolutionary new space transportation systems beginning at the turn of the century and continuing far into the future.

Space shuttle/food system study. Volume 2, Appendix F: Flight food and primary packaging

NASA Technical Reports Server (NTRS)

1974-01-01

The analysis and selection of food items and primary packaging, the development of menus, the nutritional analysis of diet, and the analyses of alternate food mixes and contingency foods is reported in terms of the overall food system design for space shuttle flight. Stowage weights and cubic volumes associated with each alternate mix were also evaluated.

Nutritional Biochemistry of Space Flight

NASA Technical Reports Server (NTRS)

Smith, Scott M.

2000-01-01

Adequate nutrition is critical for maintenance of crew health during and after extended-duration space flight. The impact of weightlessness on human physiology is profound, with effects on many systems related to nutrition, including bone, muscle, hematology, fluid and electrolyte regulation. Additionally, we have much to learn regarding the impact of weightlessness on absorption, mtabolism , and excretion of nutrients, and this will ultimately determine the nutrient requirements for extended-duration space flight. Existing nutritional requirements for extended-duration space flight have been formulated based on limited flight research, and extrapolation from ground-based research. NASA's Nutritional Biochemistry Laboratory is charged with defining the nutritional requirements for space flight. This is accomplished through both operational and research projects. A nutritional status assessment program is included operationally for all International Space Station astronauts. This medical requirement includes biochemical and dietary assessments, and is completed before, during, and after the missions. This program will provide information about crew health and nutritional status, and will also provide assessments of countermeasure efficacy. Ongoing research projects include studies of calcium and bone metabolism, and iron absorption and metabolism. The calcium studies include measurements of endocrine regulation of calcium homeostasis, biochemical marker of bone metabolism, and tracer kinetic studies of calcium movement in the body. These calcium kinetic studies allow for estimation of intestinal absorption, urinary excretion, and perhaps most importantly - deposition and resorption of calcium from bone. The Calcium Kinetics experiment is currently being prepared for flight on the Space Shuttle in 2001, and potentially for subsequent Shuttle and International Space Station missions. The iron study is intended to assess whether iron absorption is down-regulated dUl1ng space flight. This is critical due to the red blood cell changes which occur, and the increase in iron storage that has been observed after space flight. The Iron Absorption and Metabolism experiment is currently planned for long-term flights on the International Space Station.

Food technology problems related to space feeding.

PubMed

Hollender, H A; Klicka, M V; Smith, M C

1970-01-01

The development of foods suitable for extraterrestrial consumption posed unique problems. Limitations on weight, volume and stability of space food together with the lack of refrigeration favored the use of dehydrated foods on Gemini and Apollo menus. Environmental constraints, cabin pressures of 1/3 atmosphere with exposure of the food assembly to the vacuum of space in conjunction with extravehicular activities and zero gravity required special packaging and adaptation of foods considered suitable for space flight use. Requirements for acceptable, familiar, crumb free, low residue, non-gas producing, stable foods added to the complexity of the developmental effort. Four basic approaches: semisolid foods in metal tubes, dehydrated bite-size foods to be eaten dry, dehydrated foods to be reconstituted before eating and flexibly packaged thermostabilized wet meat products have been utilized in the feeding systems developed for Projects Mercury, Gemini and Apollo. The development of each type posed many interesting technologic problems. Data from current Apollo flights have pointed to certain deficiencies which still remain to be corrected. Work is progressing to eliminate current problems and to provide feeding systems suitable for both short-term and long-term space flights.

Countermeasure for space flight effects on immune system: nutritional nucleotides

NASA Technical Reports Server (NTRS)

Kulkarni, A. D.; Yamauchi, K.; Sundaresan, A.; Ramesh, G. T.; Pellis, N. R.

2005-01-01

Microgravity and its environment have adverse effects on the immune system. Abnormal immune responses observed in microgravity may pose serious consequences, especially for the recent directions of NASA for long-term space missions to Moon, Mars and deep Space exploration. The study of space flight immunology is limited due to relative inaccessibility, difficulty of performing experiments in space, and inadequate provisions in this area in the United States and Russian space programs (Taylor 1993). Microgravity and stress experienced during space flights results in immune system aberration (Taylor 1993). In ground-based mouse models for some of the microgravity effects on the human body, hindlimb unloading (HU) has been reported to cause abnormal cell proliferation and cytokine production (Armstrong et al., 1993, Chapes et al. 1993). In this report, we document that a nutritional nucleotide supplementation as studied in ground-based microgravity analogs, has potential to serve as a countermeasure for the immune dysfunction observed in space travel.

Shuttle operations era planning for flight operations

NASA Technical Reports Server (NTRS)

Holt, J. D.; Beckman, D. A.

1984-01-01

The Space Transportation System (STS) provides routine access to space for a wide range of customers in which cargos vary from single payloads on dedicated flights to multiple payloads that share Shuttle resources. This paper describes the flight operations planning process from payload introduction through flight assignment to execution of the payload objectives and the changes that have been introduced to improve that process. Particular attention is given to the factors that influence the amount of preflight preparation necessary to satisfy customer requirements. The partnership between the STS operations team and the customer is described in terms of their functions and responsibilities in the development of a flight plan. A description of the Mission Control Center (MCC) and payload support capabilities completes the overview of Shuttle flight operations.

Main medical results of extended flights on space station Mir in 1986-1990

NASA Astrophysics Data System (ADS)

Grigoriev, A. I.; Bugrov, S. A.; Bogomolov, V. V.; Egorov, A. D.; Polyakov, V. V.; Tarasov, I. K.; Shulzhenko, E. B.

During 1986-1990 seven prime spacecrews (16 cosmonauts) have flow on-board the Mir orbital complex. The longest space mission duration was 366 days. The principal objectives of the medical tasks were the maintenance of good health and performance of the spacecrews and conducting medical research programs which included study of the cardiovascular, motor, endocrine, blood, immune, and metabolic systems. Results obtained point to the ability of humans to readily adapt to a year-long stay in space and maintain good health and performance. Readaptation had a similar course as after other previous long-term space flights of up to 8 months in duration. Primary body system changes were not qualitatively different from findings after flights aboard the Salyut 6 and 7 space stations. In this case, during and after an 11-12 month flight, body system alterations were even less severe which was a result of adequate countermeasure use, their systematic and creative employment and maintenance of required environments to support life and work in space.

The Effects of Long Term Cure on Offgassed Products of Coatings

NASA Technical Reports Server (NTRS)

Engle, Ginger; Whitfield, Steve

1997-01-01

The Environmental Chemistry and Compatability Team at The Marshall Space Flight Center conducts toxic offgassing analysis on materials and flight hardware for use in habitable environments aboard the Space Shuttle and the International Space Station. As part of Research and Development, the Toxic Offgassing Laboratory conducted a long term cure study on four polyurethane coatings which are slated for potential use on Space Station. This study demonstrates the effects of cure time and temperature on the total tox value (sum T) and the maximum usage weight for each coating. All analysis was conducted according to test procedures outlined specifically for Space Station environments. Therefore, the ratings and weight limits generated for these materials are most applicable to space environments. However, this test does give some indication of time frames for solvent removal and is therefore of interest to, the environmental community as a whole.

Synthesis of ethological studies on behavioural adaptation of the astronaut to space flight conditions

NASA Astrophysics Data System (ADS)

Tafforin, Carole

The motor behaviour of the astronaut as revealed in his movement, posture and orientation is treated as observable evidence of the subject's adaptation to space flight conditions. In addition to the conservative physiological homeostasies, the quantitative description of the astronaut's motor activity in microgravity is postulated in terms of an innovative regulation, within a temporal dynamic. The proposed ethological method consists of first drawing up a specific behavioural repertoire and then of using video recordings of space missions to describe each of the behavioural units observed in the ongoing flux context in which it occurred. Finally the data is quantified into frequencies of occurrence, transition and association and completed with factorial correlation analysis. Comparison of ground training ( g = 1) and space flight ( g = 0) between the first and last day of a mission up to return to Earth gravity simulated by an anti-orthostatic decubitus experiment, reveals the nature of the adaptive strategies implemented. These strategies are evidence of changes in the behavioural repertoire including the search for predominantly visual environmental cues and the progression of motor skill during the flight. The pre-flight period is defined as a phase involving automizing of motor patterns and the post-flight period as rehabituation of strategies which have already been acquired. The phenomena observed are discussed in terms of the new spatial representation and the body image, constructed by the astronaut during his adaptation. They are considered to be optimizing for the subject's relation to his environment.

Space flight-associated neuro-ocular syndrome (SANS).

PubMed

Lee, Andrew G; Mader, Thomas H; Gibson, C Robert; Brunstetter, Tyson J; Tarver, William J

2018-03-12

Interesting novel and somewhat perplexing physiologic and pathologic neuro-ocular findings have been documented in astronauts during and after long duration space flight (LDSF). These findings collectively have been termed the "space flight-associated neuro-ocular syndrome" (SANS). The National Aeronautics and Space Administration (NASA) in the United States has meticulously and prospectively documented the clinical, ultrasound, optical coherence tomography imaging, and radiographic findings of SANS including unilateral and bilateral optic disc edema, globe flattening, choroidal and retinal folds, hyperopic refractive error shifts, and nerve fiber layer infarcts (i.e., cotton wool spots). NASA and collaborating researchers continue to study SANS in preparation for future manned missions to space, including continued trips to the ISS, a return to the moon, or perhaps new voyages to the asteroid belt, or the planet, Mars.

Behavioral, psychiatric, and sociological problems of long-duration space missions

NASA Technical Reports Server (NTRS)

Kanas, N. A.; Fedderson, W. E.

1971-01-01

A literature search was conducted in an effort to isolate the problems that might be expected on long-duration space missions. Primary sources of the search include short-term space flights, submarine tours, Antarctic expeditions, isolation-chamber tests, space-flight simulators, and hypodynamia studies. Various stressors are discussed including weightlessness and low sensory input; circadian rhythms (including sleep); confinement, isolation, and monotony; and purely psychiatric and sociological considerations. Important aspects of crew selection are also mentioned. An attempt is made to discuss these factors with regard to a prototype mission to Mars.

Spanish Language Equivalents for a Glossary of Terms Used in the Field of Space Exploration

NASA Technical Reports Server (NTRS)

Bullock, G. D.

1985-01-01

A need was identified for a reference to provide translations into Spanish of terms used in space exploration. A search for such a resource bore no fruit, so the author compiled his own glossary and obtained the translations. It was printed as a Goddard Space Flight Center X Document (X-602-82-11).

Effect of space flights on plasma hormone levels in man and in experimental animal

NASA Astrophysics Data System (ADS)

Macho, L.; Kvetňanský, R.; Vigaš, M.; Németh, S.; Popova, I.; Tigranian, R. A.; Noskov, V. B.; Serova, L.; Grigoriev, I. A.

An important increase of plasma hormone levels like insulin, TSH and aldosterone was observed in human subjects after space flights, however in the changes of plasma content of ACTH, cortisol, adrenaline and noradrenaline the individual variations were observed in relation to number and duration of space flight. For evaluation of the effects of these changes in plasma hormone levels on metabolic processes also the experiments with small animals subjected to space flights on a board of biosatellite of Cosmos series were running. An elevation of plasma levels of corticosterone, adrenaline, noradrenaline and insulin was found in rats after the space flights of duration from 7 to 20 days. It was demonstrated, that the increase of corticosterone in plasma is followed by the activation of enzymes involved in the aminoacid metabolism in rat liver (tyrosine aminotransferase, tryptophanpyrolase, alanine aminotransferase and aspartate aminotransferase). After a short recovery period (2 to 6 days) the plasma corticosterone concentration and also the activity of liver enzymes returned to control levels. The exposition of animals to stress stimuli during this recovery period showed higher response of corticosterone levels in flight rats as compared to intact controls. The increase of plasma catecholamine levels was not followed by elevation of lipolysis in adipose tissue. This is due to lower response of adipose tissue to catecholamine because a decrease of the stimulation of lipolysis by noradrenaline was observed in animals after space flight. The increase of insulin was not followed by adequate decrease of glucose concentration suggesting a disturbances in glucose utilization similarly as in cosmonauts after a long-term space flight. These results showed that changes in plasma hormone levels, observed after space flight, affected the regulation of metabolic processes in tissues.

Vestibular cerebellum of thick-toed geckos (Chondrodactylus turnery GRAY, 1864) and C57/BL6N mice after the long-term space flight on the biosatellite BION-M1.

PubMed

Alexandra, Proshchina; Anastasia, Kharlamova; Valeriy, Barabanov; Victoria, Gulimova; Sergey, Saveliev

2017-01-01

The aim of this study was to estimate the effects of long-term space flights on neuronal and glial cells of the vestibular cerebellum of C57/BL6N mice and thick-toed geckos (Chondrodactylus turnery GRAY, 1864). The cerebella from 26 mice and 13 geckos were used in this study. Ten mice and five geckos were flown aboard the BION-M1 biosatellite. The other animals were used as controls. We used immunohistochemical techniques and classical histological method to reveal cell types in the vestibular cerebellum. Nonspecific pathomorphological changes in the Purkinje cells (such as chromatolysis, vacuolization and hyperchromatosis) were observed in the flight groups. However, these changes are reversible and were also found in some neurons in the control groups. In addition, as the vestibular cerebellum is an evolutionarily stable structure, thick-toed geckos may be a useful model for space flight studies on the vertebrate cerebellum. Copyright © 2016 Elsevier B.V. All rights reserved.

Science Data Report for the Optical Properties Monitor (OPM) Experiment

NASA Technical Reports Server (NTRS)

Wilkes, Donald R.; Zwiener, James M.

1999-01-01

Long term stability of spacecraft materials when exposed to the space environment continues to be a major area of investigation. The natural and induced environment surrounding a spacecraft can decrease material performance and limit useful lifetimes. The Optical Properties Monitor (OPM) experiment provided the capability to perform the important flight testing of materials and was flown on the Russian Mir Station to study the long term effects of the natural and induced space environment on materials. The core of the OPM in-flight analysis was three independent optical instruments. These instruments included an integrating sphere spectral reflectometer, a vacuum ultraviolet spectrometer, and a Total Integrated Scatter instrument. The OPM also monitored selected components of the environment including molecular contamination. The OPM was exposed on the exterior of the Mir Docking Module for approximately 8-1/2 months. This report describes the OPM experiment, a brief background of its development, program organization, experiment description, mission overview including space environment definition, performance overview, materials data including flight and ground data, in-depth post flight analysis including ground analysis measurements and a summary discussion of the findings and results.

Low frequency vibration isolation technology for microgravity space experiments

NASA Technical Reports Server (NTRS)

Grodsinsky, Carlos M.; Brown, Gerald V.

1989-01-01

The dynamic acceleration environment observed on Space Shuttle flights to date and predicted for the Space Station has complicated the analysis of prior microgravity experiments and prompted concern for the viability of proposed space experiments requiring long-term, low-g environments. Isolation systems capable of providing significant improvements in this environment exist, but have not been demonstrated in flight configurations. This paper presents a summary of the theoretical evaluation for two one degree-of-freedom (DOF) active magnetic isolators and their predicted response to both direct and base excitations, that can be used to isolate acceleration sensitive microgravity space experiments.

The Importance of Conducting Life Sciences Experiments on the Deep Space Gateway Platform

NASA Astrophysics Data System (ADS)

Bhattacharya, S.

2018-02-01

Life science research on the Deep Space Gateway platform is an important precursor for long term human exploration of deep space. Ideas for utilizing flight hardware and well characterized model organisms will be discussed.

Body mass, energy intake, and water consumption of rats and humans during space flight

NASA Technical Reports Server (NTRS)

Wade, C. E.; Miller, M. M.; Baer, L. A.; Moran, M. M.; Steele, M. K.; Stein, T. P.

2002-01-01

Alteration of metabolism has been suggested as a major limiting factor to long-term space flight. In humans and primates, a negative energy balance has been reported. The metabolic response of rats to space flight has been suggested to result in a negative energy balance. We hypothesized that rats flown in space would maintain energy balance as indicated by maintenance of caloric intake and body mass gain. Further, the metabolism of the rat would be similar to that of laboratory-reared animals. We studied the results from 15 space flights lasting 4 to 19 d. There was no difference in average body weight (206 +/- 13.9 versus 206 +/- 14.8 g), body weight gain (5.8 +/- 0.48 versus 5.9 +/- 0.56 g/d), caloric intake (309 +/- 21.0 versus 309 +/- 20.1 kcal/kg of body mass per day), or water intake (200 +/- 8.6 versus 199 +/- 9.3 mL/kg of body mass per day) between flight and ground control animals. Compared with standard laboratory animals of similar body mass, no differences were noted. The observations suggested that the negative balance observed in humans and non-human primates may be due to other factors in the space-flight environment.

Mineral and nitrogen metabolic studies on Skylab flights and comparison with effects of earth long-term recumbency

NASA Technical Reports Server (NTRS)

Whedon, G. D.; Reid, J.; Lutwak, L.; Rambaut, P.; Whittle, M.; Leach, C.; Smith, M.

1976-01-01

A metabolic study of the effects of space flight on various chemical elements, particularly those with special relevance to the musculo-skeletal system, was carried out on the nine astronauts who participated in the three Skylab flights of 28, 59 and 84 days in 1973-1974. The study required of the cooperating crewmen constant dietary intake, continuous 24-hour urine collections and total fecal collections for 21-31 days before each flight, throughout each flight and for 17-18 days post-flight. Increases in urinary calcium and negative calcium balances during space flight were generally similar to those found in previous immobilization and bedrest studies. The persistence of these alterations in calcium metabolism throughout the flights suggested that calcium losses would continue in weightlessness for a very long time. Significant losses of nitrogen and phosphorus occurred, associated with observed reduction in muscle tissue. Both mineral and muscle losses occurred despite rigorous exercise regimens in flight. It was concluded that unless protective measures can be developed, capable musculo-skeletal function is likely to be impaired in space flights, ultimately to be conducted to Mars, of 1-1/2 to 3 years duration.

Epidemiologic Analyses of Risk Factors for Bone Loss and Recovery Related to Long-Duration Space Flight

NASA Technical Reports Server (NTRS)

Sibonga, Jean; Amin, Shreyasee

2010-01-01

AIM 1: To investigate the risk of microgravity exposure on long-term changes in bone health and fracture risk. compare data from crew members ("observed") with what would be "expected" from Rochester Bone Health Study. AIM 2: To provide a summary of current evidence available on potential risk factors for bone loss, recovery & fracture following long-duration space flight. integrative review of all data pre, in-, and post-flight across disciplines (cardiovascular, nutrition, muscle, etc.) and their relation to bone loss and recovery

The Impact of Space Flight on Survival and Interaction of Cupriavidus metallidurans CH34 with Basalt, a Volcanic Moon Analog Rock

PubMed Central

Byloos, Bo; Coninx, Ilse; Van Hoey, Olivier; Cockell, Charles; Nicholson, Natasha; Ilyin, Vyacheslav; Van Houdt, Rob; Boon, Nico; Leys, Natalie

2017-01-01

Microbe-mineral interactions have become of interest for space exploration as microorganisms could be used to biomine from extra-terrestrial material and extract elements useful as micronutrients in life support systems. This research aimed to identify the impact of space flight on the long-term survival of Cupriavidus metallidurans CH34 in mineral water and the interaction with basalt, a lunar-type rock in preparation for the ESA spaceflight experiment, BIOROCK. Therefore, C. metallidurans CH34 cells were suspended in mineral water supplemented with or without crushed basalt and send for 3 months on board the Russian FOTON-M4 capsule. Long-term storage had a significant impact on cell physiology and energy status (by flow cytometry analysis, plate count and intracellular ATP measurements) as 60% of cells stored on ground lost their cell membrane potential, only 17% were still active, average ATP levels per cell were significantly lower and cultivability dropped to 1%. The cells stored in the presence of basalt and exposed to space flight conditions during storage however showed less dramatic changes in physiology, with only 16% of the cells lost their cell membrane potential and 24% were still active, leading to a higher cultivability (50%) and indicating a general positive effect of basalt and space flight on survival. Microbe-mineral interactions and biofilm formation was altered by spaceflight as less biofilm was formed on the basalt during flight conditions. Leaching from basalt also changed (measured with ICP-OES), showing that cells release more copper from basalt and the presence of cells also impacted iron and magnesium concentration irrespective of the presence of basalt. The flight conditions thus could counteract some of the detrimental effects observed after the 3 month storage conditions. PMID:28503167

The Impact of Space Flight on Survival and Interaction of Cupriavidus metallidurans CH34 with Basalt, a Volcanic Moon Analog Rock.

PubMed

Byloos, Bo; Coninx, Ilse; Van Hoey, Olivier; Cockell, Charles; Nicholson, Natasha; Ilyin, Vyacheslav; Van Houdt, Rob; Boon, Nico; Leys, Natalie

2017-01-01

Microbe-mineral interactions have become of interest for space exploration as microorganisms could be used to biomine from extra-terrestrial material and extract elements useful as micronutrients in life support systems. This research aimed to identify the impact of space flight on the long-term survival of Cupriavidus metallidurans CH34 in mineral water and the interaction with basalt, a lunar-type rock in preparation for the ESA spaceflight experiment, BIOROCK. Therefore, C. metallidurans CH34 cells were suspended in mineral water supplemented with or without crushed basalt and send for 3 months on board the Russian FOTON-M4 capsule. Long-term storage had a significant impact on cell physiology and energy status (by flow cytometry analysis, plate count and intracellular ATP measurements) as 60% of cells stored on ground lost their cell membrane potential, only 17% were still active, average ATP levels per cell were significantly lower and cultivability dropped to 1%. The cells stored in the presence of basalt and exposed to space flight conditions during storage however showed less dramatic changes in physiology, with only 16% of the cells lost their cell membrane potential and 24% were still active, leading to a higher cultivability (50%) and indicating a general positive effect of basalt and space flight on survival. Microbe-mineral interactions and biofilm formation was altered by spaceflight as less biofilm was formed on the basalt during flight conditions. Leaching from basalt also changed (measured with ICP-OES), showing that cells release more copper from basalt and the presence of cells also impacted iron and magnesium concentration irrespective of the presence of basalt. The flight conditions thus could counteract some of the detrimental effects observed after the 3 month storage conditions.

Central and regional hemodynamics in prolonged space flights

NASA Astrophysics Data System (ADS)

Gazenko, O. G.; Shulzhenko, E. B.; Turchaninova, V. F.; Egorov, A. D.

This paper presents the results of measuring central and regional (head, forearm, calf) hemodynamics at rest and during provocative tests by the method of tetrapolar rheography in the course of Salyut-6-Soyuz and Salyut-7-Soyuz missions. The measurements were carried out during short-term (19 man-flights of 7 days in duration) and long-term (21 man-flights of 65-237 days in duration) manned missions. At rest, stroke volume (SV) and cardiac output (CO) as well as heart rate (HR) decreased insignificantly (in short-term flights) or remained essentially unchanged (in long-term flights). In prolonged flights CO increased significantly in response to exercise tests due to an increase in HR and the lack of changes in SV. After exercise tests SV and CO decreased as compared to the preflight level. During lower body negative pressure (LBNP) tests HR and CO were slightly higher than preflight. Changes in regional hemodynamics included a distinct decrease of pulse blood filling (PBF) of the calf, a reduction of the tone of large vessels of the calf and small vessels of the forearm. Head examination (in the region of the internal carotid artery) showed a decrease of PBF of the left hemisphere (during flight months 2-8) and a distinct decline of the tone of small vessels, mainly, in the right hemisphere. During LBNP tests the tone of pre- and postcapillary vessels of the brain returned to normal while PBF of the right and left hemisphere vessels declined. It has been shown that regional circulation variations depend on the area examined and are induced by a rearrangement of total hemodynamics of the human body in microgravity. This paper reviews the data concerning changes in central and regional circulation of men in space flights of different duration.

Space Launch System Trans Lunar Payload Delivery Capability

NASA Technical Reports Server (NTRS)

Jackman, A. L.; Smith, D. A.

2016-01-01

NASA Marshall Space Flight Center (MSFC) has successfully completed the Critical Design Review (CDR) of the heavy lift Space Launch System (SLS) and is working towards first flight of the vehicle in 2018. SLS will begin flying crewed missions with an Orion to a lunar vicinity every year after the first 2 flights starting in the early 2020's. So as early as 2021 these Orion flights will deliver ancillary payload, termed "Co-Manifested Payload", with a mass of at least 5.5 metric tons and volume up to 280 cubic meters to a cis-lunar destination. Later SLS flights have a goal of delivering as much as 10 metric tons to a cis-lunar destination. This presentation will describe the ground and flight accommodations, interfaces, and resources planned to be made available to Co-Manifested Payload providers as part of the SLS system. An additional intention is to promote a two-way dialogue between vehicle developers and potential payload users in order to most efficiently evolve required SLS capabilities to meet diverse payload requirements.

Space flight risk data collection and analysis project: Risk and reliability database

NASA Technical Reports Server (NTRS)

1994-01-01

The focus of the NASA 'Space Flight Risk Data Collection and Analysis' project was to acquire and evaluate space flight data with the express purpose of establishing a database containing measurements of specific risk assessment - reliability - availability - maintainability - supportability (RRAMS) parameters. The developed comprehensive RRAMS database will support the performance of future NASA and aerospace industry risk and reliability studies. One of the primary goals has been to acquire unprocessed information relating to the reliability and availability of launch vehicles and the subsystems and components thereof from the 45th Space Wing (formerly Eastern Space and Missile Command -ESMC) at Patrick Air Force Base. After evaluating and analyzing this information, it was encoded in terms of parameters pertinent to ascertaining reliability and availability statistics, and then assembled into an appropriate database structure.

Detection and Prevention of Cardiac Arrhythmias During Space Flight

NASA Technical Reports Server (NTRS)

Pillai, Dilip; Rosenbaum, David S.; Liszka, Kathy J.; York, David W.; Mackin, Michael A.; Lichter, Michael J.

2004-01-01

There have been reports suggesting that long-duration space flight might lead to an increased risk of potentially serious heart rhythm disturbances. If space flight does, in fact, significantly decrease cardiac electrical stability, the effects could be catastrophic, potentially leading to sudden cardiac death. It will be important to determine the mechanisms underlying this phenomenon in order to prepare for long-term manned lunar and interplanetary missions and to develop appropriate countermeasures. Electrical alternans affecting the ST segment and T-wave have been demonstrated to be common among patients at increased risk for ventricular arrhythmias. Subtle electrical alternans on the ECG may serve as a noninvasive marker of vulnerability to ventricular arrhythmias. We are studying indices of electrical instability in the heart for long term space missions by non-invasively measuring microvolt level T-wave alternans in a reduced gravity environment. In this investigation we are using volunteer subjects on the KC-135 aircraft as an initial study of the effect of electrical adaptation of the heart to microgravity. T-wave alternans will be analyzed for heart rate variability and QT restitution curve plotting will be compared for statistical significance.

Animals in biomedical space research

NASA Technical Reports Server (NTRS)

Phillips, R. W.

1986-01-01

Rat and squirrel monkeys experiments have been planned in concert with human experiments to help answer fundamental questions concerning the effect of weightlessness on mammalism function. For the most part, these experiments focus on identified changes noted in humans during space flight. Utilizing space laboratory facilities, manipulative experiments can be completed while animals are still in orbit. Other experiments are designed to study changes in gravity receptor structure and function and the effect of weightlessness on early vertibrate development. Following these preliminary animal experiments on Spacelab Shuttle flights, longer term programs of animal investigation will be conducted on Space Station.

Changes in cosmonauts' innate immunity after the long-term space flights

NASA Astrophysics Data System (ADS)

Ponomarev, Sergey; Rykova, Marina; Boris, Morukov; Berendeeva, Tatiana; Antropova, Evgeniya

It’s well known that the immune system is exposed to adverse influence during the space flight. For the purpose of finding out the character of similar changes in innate immunity using the flow cytometry research was spent an estimation of some key parameters characterizing a condition of natural resistance system of 8 cosmonauts before and after the long-term space flights, such as expression of Toll-like receptors (TLR2, TLR4, TLR6), adhesion molecules (CD54, CD24, CD11b, CD18), an Fc-receptor (CD16), a scavenger-receptor (CD36), a mannose receptor (CD206. Furthermore using enzyme-linked immunosorbent assay the level of the main TLR4 and TLR6 ligand - heat-shock protein 70 (HSP70) was explored. Also we defined the level of cytokine production after the lipopolysaccharide (LPS) monocyte activation in vitro. The study was conducted for 60 days before the flight, as well as at 1 and 7 days after the completion of the space missions. We found no reliable changes in the content of monocytes expressing on their surface in CD54, CD24, CD11b, CD18, CD1 and CD206. But the level of TLR2+, TLR4+, TLR6+ monocytes in all 8 cosmonauts was significantly increased on the 1 day after landing compared with the baseline values. At the same time we saw the significant increase of HSP70 in the cosmonauts’ serum on the 1 day after landing compared also with the baseline values. In spite of the increased TLR4+ monocyte level on the 1 day after landing, the LPS-induced cytokine production in the same period in cell cultures in vitro was lower than before flights. Moreover, this negative trend persisted at 7 day after the completion of long-term space missions. Such a dynamics can reflect an exhaustion of innate immunity reserve possibilities which in turn may lead to increase the infection and autoimmune diseases.

Assessing the Likelihood of Rare Medical Events in Astronauts

NASA Technical Reports Server (NTRS)

Myers, Jerry G., Jr.; Leandowski, Beth E.; Brooker, John E.; Weaver, Aaron S.

2011-01-01

Despite over half a century of manned space flight, the space flight community is only now coming to fully assess the short and long term medical dangers of exposure to reduced gravity environments. Further, as new manned spacecraft are designed and with the advent of commercial flight capabilities to the general public, a full understanding of medical risk becomes even more critical for maintaining and understanding mission safety and crew health. To address these critical issues, the National Aeronautics and Space Administration (NASA) Human Research Program (HRP) has begun to address the medical hazards with a formalized risk management approach by effectively identifying and attempting to mitigate acute and chronic medical risks to manned space flight. This paper describes NASA Glenn Research Center?s (GRC) efforts to develop a systematic methodology to assess the likelihood of in-flight medical conditions. Using a probabilistic approach, medical risks are assessed using well established and accepted biomedical and human performance models in combination with fundamentally observed data that defines the astronauts? physical conditions, environment and activity levels. Two different examples of space flight risk are used to show the versatility of our approach and how it successfully integrates disparate information to provide HRP decision makers with a valuable source of information which is otherwise lacking.

Impact of a short-term exposure to spaceflight on the phenotype, genome, transcriptome and proteome of Escherichia coli

NASA Astrophysics Data System (ADS)

Li, Tianzhi; Chang, De; Xu, Huiwen; Chen, Jiapeng; Su, Longxiang; Guo, Yinghua; Chen, Zhenhong; Wang, Yajuan; Wang, Li; Wang, Junfeng; Fang, Xiangqun; Liu, Changting

2015-07-01

Escherichia coli (E. coli) is the most widely applied model organism in current biological science. As a widespread opportunistic pathogen, E. coli can survive not only by symbiosis with human, but also outside the host as well, which necessitates the evaluation of its response to the space environment. Therefore, to keep humans safe in space, it is necessary to understand how the bacteria respond to this environment. Despite extensive investigations for a few decades, the response of E. coli to the real space environment is still controversial. To better understand the mechanisms how E. coli overcomes harsh environments such as microgravity in space and to investigate whether these factors may induce pathogenic changes in E. coli that are potentially detrimental to astronauts, we conducted detailed genomics, transcriptomic and proteomic studies on E. coli that experienced 17 days of spaceflight. By comparing two flight strains LCT-EC52 and LCT-EC59 to a control strain LCT-EC106 that was cultured under the same temperature conditions on the ground, we identified metabolism changes, polymorphism changes, differentially expressed genes and proteins in the two flight strains. The flight strains differed from the control in the utilization of more than 30 carbon sources. Two single nucleotide polymorphisms (SNPs) and one deletion were identified in the flight strains. The expression level of more than 1000 genes altered in flight strains. Genes involved in chemotaxis, lipid metabolism and cell motility express differently. Moreover, the two flight strains also differed extensively from each other in terms of metabolism, transcriptome and proteome, indicating the impact of space environment on individual cells is heterogeneous and probably genotype-dependent. This study presents the first systematic profile of E. coli genome, transcriptome and proteome after spaceflight, which helps to elucidate the mechanism that controls the adaptation of microbes to the space environment.

Time-dependent radiation dose estimations during interplanetary space flights

NASA Astrophysics Data System (ADS)

Dobynde, M. I.; Shprits, Y.; Drozdov, A.

2015-12-01

Time-dependent radiation dose estimations during interplanetary space flights 1,2Dobynde M.I., 2,3Drozdov A.Y., 2,4Shprits Y.Y.1Skolkovo institute of science and technology, Moscow, Russia 2University of California Los Angeles, Los Angeles, USA 3Lomonosov Moscow State University Skobeltsyn Institute of Nuclear Physics, Moscow, Russia4Massachusetts Institute of Technology, Cambridge, USASpace radiation is the main restriction for long-term interplanetary space missions. It induces degradation of external components and propagates inside providing damage to internal environment. Space radiation particles and induced secondary particle showers can lead to variety of damage to astronauts in short- and long- term perspective. Contribution of two main sources of space radiation- Sun and out-of-heliosphere space varies in time in opposite phase due to the solar activity state. Currently the only habituated mission is the international interplanetary station that flights on the low Earth orbit. Besides station shell astronauts are protected with the Earth magnetosphere- a natural shield that prevents significant damage for all humanity. Current progress in space exploration tends to lead humanity out of magnetosphere bounds. With the current study we make estimations of spacecraft parameters and astronauts damage for long-term interplanetary flights. Applying time dependent model of GCR spectra and data on SEP spectra we show the time dependence of the radiation in a human phantom inside the shielding capsule. We pay attention to the shielding capsule design, looking for an optimal geometry parameters and materials. Different types of particles affect differently on the human providing more or less harm to the tissues. Incident particles provide a large amount of secondary particles while propagating through the shielding capsule. We make an attempt to find an optimal combination of shielding capsule parameters, namely material and thickness, that will effectively decrease the incident particle energy, at the same time minimizing flow of secondary induced particles and minimizing most harmful particle types flows.

Human Activity Behavior and Gesture Generation in Virtual Worlds for Long- Duration Space Missions. Chapter 8

NASA Technical Reports Server (NTRS)

Sierhuis, Maarten; Clancey, William J.; Damer, Bruce; Brodsky, Boris; vanHoff, Ron

2007-01-01

A virtual worlds presentation technique with embodied, intelligent agents is being developed as an instructional medium suitable to present in situ training on long term space flight. The system combines a behavioral element based on finite state automata, a behavior based reactive architecture also described as subsumption architecture, and a belief-desire-intention agent structure. These three features are being integrated to describe a Brahms virtual environment model of extravehicular crew activity which could become a basis for procedure training during extended space flight.

Natural killer cells after altaïr mission

NASA Astrophysics Data System (ADS)

Konstantinova, I. V.; Rykova, M.; Meshkov, D.; Peres, C.; Husson, D.; Schmitt, D. A.

Reduced in vitro NK cytotoxic activity have routinely been observed after both prolonged and short-term space flights. This study investigated the effects of space flight on NK cell functions, NK cell counts and the production of IL-2 and TNF by lymphocytes of French-Russian crew members. In the French cosmonaut, after 21 days space flight, the cytotoxic activity of NK cells, the capacity the NK cells to bind and lyse the individual target cells and the percentage of NK cells were decreased. In this cosmonaut a twofold reduction TNF production in cultures of lymphocytes stimulated with PMA and with the mixture of PHA and PMA was observed on the first day after landing. However, the activity of the production of TNF in 48-hour PHA-cultures of lymphocytes was unchanged and the biological activity of IL-2 was not reduced. The immunological examination did not detecte any substantial deviations from the norm in both russian cosmonauts after 197 days space flight. Various explanations for decreased cytotoxicity in cosmonauts after space flight can be proposed, and these include the defective function of NK cells and reduced numbers of circulating effector cells.

Langley applications experiments data management system study. [for space shuttles

NASA Technical Reports Server (NTRS)

Lanham, C. C., Jr.

1975-01-01

A data management system study is presented that defines, in functional terms, the most cost effective ground data management system to support Advanced Technology Laboratory (ATL) flights of the space shuttle. Results from each subtask performed and the recommended system configuration for reformatting the experiment instrumentation tapes to computer compatible tape are examined. Included are cost factors for development of a mini control center for real-time support of the ATL flights.

Electric Propulsion Space Experiment (ESEX): Spacecraft design issues for high-power electric propulsion

NASA Astrophysics Data System (ADS)

Kriebel, Mary M.; Sanks, Terry M.

1992-02-01

Electric propulsion provides high specific impulses, and low thrust when compared to chemical propulsion systems. Therefore, electric propulsion offers improvements over chemical systems such as increased station-keeping time, prolonged on-orbit maneuverability, low acceleration of large structures, and increased launch vehicle flexibility. The anticipated near-term operational electric propulsion system for an electric orbit transfer vehicle is an arcjet propulsion system. Towards this end, the USAF's Phillips Laboratory (PL) has awarded a prime contract to TRW Space & Technology Group to design, build, and space qualify a 30-kWe class arcjet as well as develop and demonstrate, on the ground, a flight-qualified arcjet propulsion flight unit. The name of this effort is the 30 kWe Class Arcjet Advanced Technology Transition Demonstration (Arcjet ATTD) program. Once the flight unit has completed its ground qualification test, it will be given to the Space Test and Transportation Program Office of the Air Force's Space Systems Division (ST/T) for launch vehicle integration and space test. The flight unit's space test is known as the Electric Propulsion Space Experiment (ESEX). ESEX's mission scenario is 10 firings of 15 minutes each. The objectives of the ESEX flight are to measure arcjet plume deposition, electromagnetic interference, thermal radiation, and acceleration in space. Plume deposition, electromagnetic interference, and thermal radiation are operational issues that are primarily being answered for operational use. This paper describes the Arcjet ATTD flight unit design and identifies specifically how the diagnostic data will be collected as part of the ESEX program.

Analysis of body calcium (regional changes in body calcium by in vivo neutron activation analysis)

NASA Technical Reports Server (NTRS)

Suki, W.; Johnson, P. C.; Leblanc, A.; Evans, H. J.

1981-01-01

The effect of space flight on urine and fecal calcium loss was documented during the three long-term Skylab flights. Neutron activation analysis was used to determine regional calcium loss. Various designs for regional analysis were investigated.

Bone Density Following Three Years of Recovery from Long-Duration Space-Flight

NASA Technical Reports Server (NTRS)

Amin, S.; Achenbach, S. J.; Atkinson, E. J.; Sibonga, J.

2010-01-01

Bone loss during long-duration space flight is well recognized, but the long-term implications on bone health following return from flight remain unclear. Among US crew who were involved in long-duration missions in space (Mir and ISS), we have previously shown that at approximately 12 months following return, men, but not women, had BMD values at most sites that were still lower than would be expected had they not been exposed to a prolonged period of microgravity. We now extend our observations to 3 years of follow-up post-flight. Using their age, pre-flight BMD and follow-up time, post-flight BMD values for each US crew were predicted based on the model developed from the community sample. We found BMD measures to be either stable or improve by 3 years relative to their immediate post-flight BMD, however only total hip BMD still remains significantly lower than would be expected had they not been exposed to microgravity. Among male US crew, who have had their BMD measured following at least 3 years of recovery post long-duration flight, they continue to have lower BMD at the hip than would be expected, raising potential concerns regarding future hip fracture risk.

NASA thesaurus: Astronomy vocabulary

NASA Technical Reports Server (NTRS)

1988-01-01

A terminology of descriptors used by the NASA Scientific and Technical information effort to index documents in the area of astronomy is presented. The terms are listed in hierarchical format derived from the 1988 edition of the NASA Thesaurus Volume 1 -- Hierarchical Listing. Over 1600 terms are included. In addition to astronomy, space sciences covered include astrophysics, cosmology, lunar flight and exploration, meteors and meteorites, celestial mechanics, planetary flight and exploration, and planetary science.

Investigation of Desiccants and CO2 Sorbents for Advanced Exploration Systems 2016-2017

NASA Technical Reports Server (NTRS)

Knox, Jim; Cmarik, Gregory E.

2017-01-01

Advanced Environmental Control and Life Support System (ECLSS) design is critical for manned space flight beyond Earth. Current systems enable extended missions in low-Earth orbit, but for deep-space missions, not only will astronauts be outside the reach of resupply operations from Earth but they will also need to handle malfunctions and compensate for the degradation of materials. These two daunting challenges must be overcome for long-term independent space flight. In order to solve the first, separation and recycling of onboard atmosphere is required. Current systems utilize space vacuum to fully regenerate CO2 sorbent beds, but this is not sustainable. The second challenge stems from material and performance degradation due to operational cycling and on-board contaminants. This report will review the recent work by the ECLSS team at Marshall Space Flight Center towards overcoming these challenges by characterizing materials via novel methods and by assessing new air revitalization systems.

Material Analysis and System Design for Exploration Life Support Systems 2017

NASA Technical Reports Server (NTRS)

Knox, Jim; Cmarik, Gregory E.

2017-01-01

Advanced Environmental Control and Life Support System (ECLSS) design is critical for manned space flight beyond Earth. Current systems enable extended missions in low-Earth orbit, but for deep-space missions, not only will astronauts be outside the reach of resupply operations from Earth but they will also need to handle malfunctions and compensate for the degradation of materials. These two daunting challenges must be overcome for long-term independent space flight. In order to solve the first, separation and recycling of onboard atmosphere is required. Current systems utilize space vacuum to fully regenerate CO2 sorbent beds, but this is not sustainable. The second challenge stems from material and performance degradation due to operational cycling and on-board contaminants. This report will review the recent work by the ECLSS team at Marshall Space Flight Center towards overcoming these challenges by characterizing materials via novel methods and by assessing new air revitalization systems.

Space Biology and Medicine. Volume 4; Health, Performance, and Safety of Space Crews

NASA Technical Reports Server (NTRS)

Dietlein, Lawrence F. (Editor); Pestov, Igor D. (Editor)

2004-01-01

Volume IV is devoted to examining the medical and associated organizational measures used to maintain the health of space crews and to support their performance before, during, and after space flight. These measures, collectively known as the medical flight support system, are important contributors to the safety and success of space flight. The contributions of space hardware and the spacecraft environment to flight safety and mission success are covered in previous volumes of the Space Biology and Medicine series. In Volume IV, we address means of improving the reliability of people who are required to function in the unfamiliar environment of space flight as well as the importance of those who support the crew. Please note that the extensive collaboration between Russian and American teams for this volume of work resulted in a timeframe of publication longer than originally anticipated. Therefore, new research or insights may have emerged since the authors composed their chapters and references. This volume includes a list of authors' names and addresses should readers seek specifics on new information. At least three groups of factors act to perturb human physiological homeostasis during space flight. All have significant influence on health, psychological, and emotional status, tolerance, and work capacity. The first and most important of these factors is weightlessness, the most specific and radical change in the ambient environment; it causes a variety of functional and structural changes in human physiology. The second group of factors precludes the constraints associated with living in the sealed, confined environment of spacecraft. Although these factors are not unique to space flight, the limitations they entail in terms of an uncomfortable environment can diminish the well-being and performance of crewmembers in space. The third group of factors includes the occupational and social factors associated with the difficult, critical nature of the crewmembers' work: the risks involved in space flight, changes in circadian rhythms, and intragroup interactions. The physical and emotional stress and fatigue that develop under these conditions also can disturb human health and performance. In addition to these factors, the risk also exists that crewmembers will develop various illnesses during flight. The risk of illness is no less during space flight than on Earth, and may actually be greater for some classes of diseases.

Medical considerations for extending human presence in space

NASA Technical Reports Server (NTRS)

Leach, C. S.; Dietlein, L. F.; Pool, S. L.; Nicogossian, A. E.

1990-01-01

The prospects for extending the length of time that humans can safely remain in space depend partly on resolution of a number of medical issues. Physiologic effects of weightlessness that may affect health during flight include loss of body fluid, functional alterations in the cardiovascular system, loss of red blood cells and bone mineral, compromised immune system function, and neurosensory disturbances. Some of the physiologic adaptations to weightlessness contribute to difficulties with readaptation to Earth's gravity. These include cardiovascular deconditioning and loss of body fluids and electrolytes; red blood cell mass; muscle mass, strength, and endurance; and bone mineral. Potentially harmful factors in space flight that are not related to weightlessness include radiation, altered circadian rhythms and rest/work cycles, and the closed, isolated environment of the spacecraft. There is no evidence that space flight has long-term effects on humans, except that bone mass lost during flight may not be replaced, and radiation damage is cumulative. However, the number of people who have spent several months or longer in space is still small. Only carefully-planned experiments in space preceded by thorough ground-based studies can provide the information needed to increase the amount of time humans can safely spend in space.

Assessment and Mitigation of the Effects of Noise on Habitability in Deep Space Environments: Report on Non-Auditory Effects of Noise

NASA Technical Reports Server (NTRS)

Begault, Durand R.

2018-01-01

This document reviews non-auditory effects of noise relevant to habitable volume requirements in cislunar space. The non-auditory effects of noise in future long-term space habitats are likely to be impactful on team and individual performance, sleep, and cognitive well-being. This report has provided several recommendations for future standards and procedures for long-term space flight habitats, along with recommendations for NASA's Human Research Program in support of DST mission success.

Radiation hazard during a manned mission to Mars.

PubMed

Jäkel, Oliver

2004-01-01

The radiation hazard of interplanetary flights is currently one of the major obstacles to manned missions to Mars. Highly energetic, heavy-charged particles from galactic cosmic radiation can not be sufficiently shielded in space vehicles. The long-term radiation effects to humans of these particles are largely unknown. In addition, unpredictable storms of solar particles may expose the crew to doses that lead to acute radiation effects. A manned flight to Mars currently seems to be a high-risk adventure. This article provides an overview on the radiation sources and risks for a crew on a manned flight to Mars, as currently estimated by scientists of the US National Administration for Space and Aeronautics (NASA) and the Space Studies Board (SSB) of the US National Research Council.

Eugen Sänger: Eminent space pioneer

NASA Astrophysics Data System (ADS)

Kerstein, Aleksander; Matko, Drago

2007-12-01

In international literature on astronautics, three main space pioneers are mentioned: Konstantin E. Tsiolkovsky, Robert H. Goddard and Hermann Oberth. There are other two space pioneers that are very rarely mentioned: Robert Esnault-Pelterie and Eugen Sänger. Pelterie is known particularly in Europe, and Sänger is mentioned in the second half of the 20th century normally only in connection with space shuttle flights. Taking a look at Sänger's work and heritage, it is obvious that he greatly influenced the development of astronautics in terms of purely theoretical dissertations on achievable limits of space research as well as in terms of technical approaches to achieving the short- and long-term goals of astronautics, and in terms of setting tasks for organizing mankind to achieve these goals. Sänger's book "The Technology of Rocket Flight" was the first study based not only on basic research, but also on the applied research that he conducted and the findings of which he published in various papers. Sänger was clearly connected with and influenced the development of two experimental research groups in the US in the 1930s, which resulted in two of the most significant companies in the US in the 1950s that manufactured liquid propellant rocket engines. Basic and applied research in the field of space planes resulted in construction of rocket planes such as the US space shuttle and Soviet Buran shuttle. Sänger's research on subsonic and supersonic ramjets in combination with a turbojet engine provided a basis for developing this promising propulsion for use in subsequent space planes designed for flights into low Earth orbits. His pioneering work on the photon rocket represents human achievements in reaching almost unimaginable limits of space research. By striving for a peaceful international approach to space research, Sänger participated in establishing the non-governmental organization IAF (International Astronautical Federation) and realized his idea that space research is a concern for all mankind. He was therefore appointed the first president of the IAF. The paper presents how Sänger influenced the development of rocket technology and astronautics, which definitely ranks him with the first three space pioneers.

Problems associated with the utilization of algae in bioregenerative life support systems

NASA Technical Reports Server (NTRS)

Averner, M. M.; Karel, M.; Radmer, R.

1984-01-01

A workshop was conducted to identify the potential problems associated with the use of microalgae in biorregenerative life support systems, and to identify algae rlated research issues that must be addressed through space flight experimentation. Major questions to be resolved relate to the choice of algal species for inclusion in a bioregenerative life support system, their long term behavior in the space environment, and the nature of the techniques required for the continuous growth of algae on the scale required. Consideration was given to the problems associated with the conversion of algal biomass into edible components. Specific concerns were addressed and alternative transformation processes identified and compared. The workshop identified the following major areas to be addressed by space flight experimentation: (1) long term culture stability, (2) optimal design of algal growth reactors, and (3) post growth harvesting and processing in the space environment.

The XP spaceplane: A near term multi-purpose suborbital RLV

NASA Astrophysics Data System (ADS)

Lauer, Charles J.

2007-06-01

This paper will describe the history, technology and design features of the XP spaceplane being developed by Rocketplane Ltd. in Oklahoma. The XP is a four seat fighter-sized spaceplane that uses turbojets for takeoff and landing and a liquid oxygen/kerosene rocket engine for main propulsion during its ascent to a 100 km apogee suborbital space flight. The XP is intended to serve a variety of markets including suborbital tourist flights, intermediate duration microgravity research, remote sensing, astronomy, and microsatellite launch missions. Changes in vehicle configuration and flight profile for serving each of these markets will be described. The prototype XP will have its rollout ceremony at the end of 2007 and will begin test flights in early 2008. Commercial space flight operations are expected to begin in fall 2008 with tourist flights and microgravity research flights being the early customer base. The spaceplane's flight systems, safety systems, and operating procedures will be reviewed. In addition, key elements of the Rocketplane business and financial model will be discussed.

Space Medicine: A Surgeon's Perspective

NASA Technical Reports Server (NTRS)

Dawson, David L.

1999-01-01

For the first four decades of human space flight NASA's priorities in life sciences and medical programs have been preventative medicine (astronaut selection and training); assessment of the physiologic effects of microgravity and other unique aspects of space flight, implementation of countermeasures to protect against adverse effects, and amelioration of these adverse effects. Because most of the U.S. space flight experience has been on short duration missions, the need for medical and diagnostic treatment capabilities have been limited.The first long-term crews will arrive on the International Space Station (ISS) in early 2000. This will usher in a new era, an era of sustained human presence in Low Earth Orbit. One of the principal purposes of the ISS program is to increase the knowledge of the effects of long duration space flight on humans, a pre-requisite to future exploration class missions beyond Low Earth Orbit (e.g., a return to the Moon or an exploration of Mars). Areas of particular interest include protection from radiation, muscle atrophy, bone loss, cardiovascular alterations, immune dysfunction, adverse psychological response to hazards and confinement, and neurovestibular alterations. In addition, long duration space flight requires the development of autonomous medical care capabilities, as the distances involved eliminate the possibility of real-time telemedicine or robotic intervention, and prevent a mission abort and a rapid return to Earth. The objectives of this presentation include: 1. A description of the International Space Station project, including its research facilities and on-orbit medical capabilities; 2. An overview of the physiological and medical problems associated with microgravity in space flight; 3. A review of NASA's biomedical research priorities and ongoing work to develop clinical care capabilities for space flight crews (including surgical interventions) and; 4. An overview of current and proposed research priorities for NASA Research Announcements, NASA Space Biomedical Research Institute, Small Business Innovation Research Grant, and other funding sources.

Cultivation in space flight produces minimal alterations in the susceptibility of Bacillus subtilis cells to 72 different antibiotics and growth-inhibiting compounds.

PubMed

Morrison, Michael D; Fajardo-Cavazos, Patricia; Nicholson, Wayne L

2017-08-18

Past results have suggested that bacterial antibiotic susceptibility is altered during space flight. To test this notion, Bacillus subtilis cells were cultivated in matched hardware, medium, and environmental conditions either in spaceflight microgravity on the International Space Station, termed Flight (FL) samples, or at Earth-normal gravity, termed Ground Control (GC) samples. Susceptibility of FL and GC samples was compared to 72 antibiotics and growth-inhibitory compounds using the Omnilog Phenotype Microarray (PM) system. Only 9 compounds were identified by PM screening as exhibiting significant differences ( P < 0.05, Student's t-test) in FL vs. GC samples: 6-mercaptopurine, cesium chloride, enoxacin, lomefloxacin, manganese (II) chloride, nalidixic acid, penimepicycline, rolitetracycline, and trifluoperazine. Testing of the same compounds by standard broth dilution assay did not reveal statistically significant differences in the IC 50 values between FL and GC samples. The results indicate that the susceptibility of B. subtilis cells to a wide range of antibiotics and growth inhibitors is not dramatically altered by space flight. Importance: This study addresses a major concern of mission planners for human spaceflight, that bacteria accompanying astronauts on long-duration missions might develop a higher level of resistance to antibiotics due to exposure to the spaceflight environment. The results of this study do not support that notion. Copyright © 2017 American Society for Microbiology.

Changes of hormones regulating electrolyte metabolism after space flight and hypokinesia

NASA Astrophysics Data System (ADS)

Macho, L.; Fickova, M.; Lichardus, B.; Kvetnansky, R.; Carrey, R. M.; Grigoriev, A.; Popova, I. A.; Tigranian, R. A.; Noskov, V. B.

The changes of hormones in plasma involved in the body fluid regulation were studied in human subjects during and after space flights in relation to redistribution of body fluids in the state of weightlessness. Since hypokinesia was used as a model for simulation of some effects of the stay in microgravity the plasma hormone levels in rats exposed to hypokinesia were also investigated. Plasma aldosterone values showed great individual variations during the first inflight days, the increased levels were observed with prolongation of space flights. The important elevation was found in the recovery period, however it was interesting to note, that in some cosmonauts with repeated exposure to space flight, the postflight plasma aldosterone levels were not elevated. The urine excretion of aldosterone was increased inflight, however in postflight period the decrease or increase were found in the first 1-5 days. The increase of plasma renin activity was observed in flight and postflight period. The rats were exposed to hypokinesia (forced restriction of motor activity) for 1, 7 and 60 days and urine was collected during last 24 hours. The animals were sacrificed and the concentration of electrolytes and of levels of corticosterone aldosteron (A), ANF and plasma-renin activity (PRA) were determined in plasma. In urine excretion of sodium and potassium were estimated. An important increase of plasma renin activity and aldosterone concentration was found after short-term hypokinesia (1 day). These hormonal values appear to decrease with time (7 days) and are not significantly different from controls after long-term hypokinesia (60 days). A decrease of values ANF in plasma was observed after 1 and 7 days hypokinesia. After prolonged hypokinesia a decrease of sodium plasma concentration was observed. The excretion of sodium in urine was higher in long-term hypokinetic animals. There were no significant changes of plasma potassium levels in rats exposed to hypokinesia, however the urinary excretion of potassium was elevated. In rats exposed to hypokinesia for 7 and 60 days an increase of urine osmolality was observed. The results of hormone and electrolyte determination in plasma of cosmonauts after space flight and in experimental animals after hypokinesia suggested that in evaluation of relations between the changes of hormone levels and electrolyte in plasma and urine other factors like emotional stress working load; altered diurnal cycles should be considered in interpretation of homeostatic response of fluid and electrolyte metabolism to space flight conditions.

Surviving the space environment - An overview of advanced materials and structures development at the CWRU CCDS

NASA Technical Reports Server (NTRS)

Wallace, John F.; Zdankiewicz, Edward M.; Schmidt, Robert N.

1991-01-01

The development of advanced materials and structures for long-term use in space is described with specific reference given to applications to the Space Station Freedom and the lunar base. A flight-testing program is described which incorporates experiments regarding the passive effects of space travel such as material degradation with active materials experiments such as the Materials Exposure Flight Experiment. Also described is a research and development program for materials such as organic coatings and polymeric composites, and a simulation laboratory is described which permits the analysis of materials in the laboratory. The methods of investigation indicate that the NASA Center for the Commercial Development of Space facilitates the understanding of material degradation in space.

Work, exercise, and space flight. 1: Operations, environment, and effects of spaceflight

NASA Technical Reports Server (NTRS)

Thornton, William

1989-01-01

The selection, training, and operations of space flight impose significant physical demands which seem to be adequately met by the existing physical training facilities and informal individual exercise programs. The professional astronaut population has, by selection, better than average health and physical capacity. The essentials of life on earth are adequately met by the spacecraft. However, as the human body adapts to weightlessness, it is compromised for the usual life on earth, but readaptation is rapid. Long term flight without countermeasures will produce major changes in the cardiovascular, respiratory, musculoskeletal and neuromuscular systems. There is strong theoretical and experimental evidence from 1-g studies and limited in-flight evidence to believe that exercise is a key counter-measure to many of these adaptations.

Proteomic Analysis of Hair Follicles

NASA Astrophysics Data System (ADS)

Ishioka, Noriaki; Terada, Masahiro; Yamada, Shin; Seki, Masaya; Takahashi, Rika; Majima, Hideyuki J.; Higashibata, Akira; Mukai, Chiaki

2013-02-01

Hair root cells actively divide in a hair follicle, and they sensitively reflect physical conditions. By analyzing the human hair, we can know stress levels on the human body and metabolic conditions caused by microgravity environment and cosmic radiation. The Japan Aerospace Exploration Agency (JAXA) has initiated a human research study to investigate the effects of long-term space flight on gene expression and mineral metabolism by analyzing hair samples of astronauts who stayed in the International Space Station (ISS) for 6 months. During long-term flights, the physiological effects on astronauts include muscle atrophy and bone calcium loss. Furthermore, radiation and psychological effects are important issue to consider. Therefore, an understanding of the effects of the space environment is important for developing countermeasures against the effects experienced by astronauts. In this experiment, we identify functionally important target proteins that integrate transcriptome, mineral metabolism and proteome profiles from human hair. To compare the protein expression data with the gene expression data from hair roots, we developed the protein processing method. We extracted the protein from five strands of hair using ISOGEN reagents. Then, these extracted proteins were analyzed by LC-MS/MS. These collected profiles will give us useful physiological information to examine the effect of space flight.

14 CFR 91.1063 - Testing and training: Applicability and terms used.

Code of Federal Regulations, 2013 CFR

2013-01-01

... proficiency check requirements of § 91.1069. (iii) Testing requirements of § 91.1065. (iv) Recurrent flight... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Testing and training: Applicability and... TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES GENERAL OPERATING AND FLIGHT RULES Fractional...

14 CFR 91.1063 - Testing and training: Applicability and terms used.

Code of Federal Regulations, 2010 CFR

2010-01-01

... proficiency check requirements of § 91.1069. (iii) Testing requirements of § 91.1065. (iv) Recurrent flight... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Testing and training: Applicability and... TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES GENERAL OPERATING AND FLIGHT RULES Fractional...

14 CFR 91.1063 - Testing and training: Applicability and terms used.

Code of Federal Regulations, 2012 CFR

2012-01-01

... proficiency check requirements of § 91.1069. (iii) Testing requirements of § 91.1065. (iv) Recurrent flight... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Testing and training: Applicability and... TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES GENERAL OPERATING AND FLIGHT RULES Fractional...

14 CFR 91.1063 - Testing and training: Applicability and terms used.

Code of Federal Regulations, 2011 CFR

2011-01-01

... proficiency check requirements of § 91.1069. (iii) Testing requirements of § 91.1065. (iv) Recurrent flight... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Testing and training: Applicability and... TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES GENERAL OPERATING AND FLIGHT RULES Fractional...

14 CFR 91.1063 - Testing and training: Applicability and terms used.

Code of Federal Regulations, 2014 CFR

2014-01-01

... proficiency check requirements of § 91.1069. (iii) Testing requirements of § 91.1065. (iv) Recurrent flight... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Testing and training: Applicability and... TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES GENERAL OPERATING AND FLIGHT RULES Fractional...

Research Opportunities in Nutrition and Metabolism in Space

NASA Technical Reports Server (NTRS)

Altman, Philip L. (Editor); Fisher, Kenneth D. (Editor)

1986-01-01

The objectives of the Life Sciences Research Office (LSRO) study on nutrient requirements for meeting metabolic needs in manned space flights are as follows: review extant knowledge on the subject; identify significant gaps in knowledge; formulate suggestions for possible research; and produce a documented report of the foregoing items that can be used for program planning. In accordance with NASA's request for this study, the report focuses on issues of nutrition and metabolism that relate primarily to the contemplated United States Space Station, secondarily to the Shuttle Program as an orbital test bed for operational studies, and incidentally to scenarios for future long-term space flights. Members of the LSRO ad hoc Working Group on Nutrition and Metabolism were provided with pertinent articles and summaries on the subject. At the meeting of the Working Group, presentations were made by NASA Headquarters program staff on past experiences relative to space-flight nutrition and metabolism, as well as scenarios for future flights. The discussions of the ad hoc Working Group focused on the following: (1) metabolic needs related to work and exercise; (2) nutrients required to meet such needs; (3) food types, management, and records; and (4) nutritional amelioration or prevention of space-related physiological and behavioral changes.

On the Utilization of In-flight Radiation-induced Performance Data and Anomaly Resolution of Commercial Off the Shelf (COTS) Electronics

NASA Technical Reports Server (NTRS)

LeBel, Kenneth A.; Poivey, Christian; Barth, Janet L.

2003-01-01

This viewgraph presentation presents an overview of the use of in-flight science data to review the radiation effects on commercial off the shelf (COTS) electronics used in recent spacecraft missions. The authors review the hazards that the space radiation environment pose for spacecraft electronics. They specifically discuss long term effects such as total ionizing dose (TID) and short term effects like single particle events (SEE). The advantages of using COTS electronics despite not being radiation hardened are mentioned. The reasons cite for tracking in-flight performance of COTS electronics include: anomaly resolution, validate ground tests and environmental predictions and provide lessons for future designers. Sample radiation impacts of science data from the following missions are analyzed: SOHO/LASCO 3 Coronograph, Microwave Anisotrophy Probe, Hubble Space Telescope and Chandra X-Ray Observatory.

An Update on Mortality in the U.S. Astronaut Corps: 1959-2009

NASA Technical Reports Server (NTRS)

Amirian, E.; Clark, April; Halm, Melissa; Hartnett, Heather

2009-01-01

Although it has now been over 50 years since mankind first ventured into space, the long-term health impacts of human space flight remain largely unknown. Identifying factors that affect survival and prognosis among those who participate in space flight is vitally important, as the era of commercial space flight approaches and NASA prepares for missions to Mars. The Longitudinal Study of Astronaut Health is a prospective study designed to examine trends in astronaut morbidity and mortality. The purpose of this analysis was to describe and explore predictors of overall and cause-specific mortality among individuals selected for the U.S. astronaut corps. All U.S. astronauts (n=321), regardless of flight status, were included in this analysis. Death certificate searches were conducted to ascertain vital status and cause of death through April 2009. Data were collected from medical records and lifestyle questionnaires. Multivariable Cox regression modeling was used to calculate the mortality hazard associated with embarking on space flight, adjusted for sex, race, and age at selection. Between 1959 and 2009, there were 39 (12.1%) deaths. Of these deaths, 18 (42.2%) were due to occupational accidents; 7 (17.9%) were due to other accidents; 6 (15.4%) were attributable to cancer; 6 (15.4%) resulted from cardiovascular/circulatory diseases; and 2 (5.1%) were from other causes. Participation in space flight did not significantly increase mortality hazard over time (adjusted hazard ratio=0.57; 95% confidence interval=0.26-1.26. Because our results are based on a small sample size, future research that includes payload specialists, other space flight participants, and international crew members is warranted to maximize statistical power.

Center for Cell Research, Pennsylvania State University

NASA Technical Reports Server (NTRS)

Cronin, Mike

1991-01-01

A brief review of Genentech, Inc., is presented. Additionally, the Physiological Systems Experiment (PSE-01) is discussed in terms of its development history. The PSE-01 was developed to investigate the bone wasting, muscle wasting, and immune cell dysfunction that occur in microgravity conditions. Specifically, a number of human disorders are associated with maladaptive changes in bone, muscle, and immune function. The physiological adjustments that the body makes in response to space flight can be monitored and may aid in the discovery of new protein forms and patterns. This research may also provide strategies for protecting the health of flight crews enduring prolonged space flight. Results are discussed.

Skylab

NASA Image and Video Library

1972-05-01

One of the most successful of the Skylab educational efforts was the Skylab Student Project. This was a nationwide contest in which secondary school students submitted proposals for experiments to fly on Skylab. After the official announcement of this project, over 4,000 students responded with 3,409 proposals from which 25 winners were selected. In the subsequent evaluation of these 25 proposed experiments in terms of their suitability for flight, the Marshall Space Flight Center, the lead center for Skylab, selected 19. This photograph is a group shot of the 25 winners in the Skylab student program when they met for the first time at the Marshall Space Flight Center in May 1972.

Perspectives on NASA flight software development - Apollo, Shuttle, Space Station

NASA Technical Reports Server (NTRS)

Garman, John R.

1990-01-01

Flight data systems' software development is chronicled for the period encompassing NASA's Apollo, Space Shuttle, and (ongoing) Space Station Freedom programs, with attention to the methodologies and 'development tools' employed in each case and their mutual relationships. A dominant concern in all three programs has been the accommodation of software change; it has also been noted that any such long-term program carries the additional challenge of identifying which elements of its software-related 'institutional memory' are most critical, in order to preclude their loss through the retirement, promotion, or transfer of its 'last expert'.

STS-108 Crew Interviews: Mark Kelly

NASA Technical Reports Server (NTRS)

2001-01-01

STS-108 Pilot Mark Kelly is seen during a prelaunch interview. He answers questions about the mission's goals and significance, explaining the meaning of 'utilization flight 1' (UF-1) as opposed to an 'assembly flight'. He gives details on the payload (Starshine Satellite, Avian Development Facility, and Rafaello Multipurpose Logistics Module (MPLM)), his role in the rendezvous, docking, and undocking of the Endeavour Orbiter to the International Space Station (ISS), how he will participate in the unloading and reloading of the MPLM, and the way in which the old and new resident crews of ISS will exchanged. Kelly ends with his thoughts on the short-term and long-term future of the International Space Station.

STS-108 Crew Interviews: Linda Godwin

NASA Technical Reports Server (NTRS)

2001-01-01

STS-108 Mission Specialist Linda Godwin is seen during a prelaunch interview. She answers questions about the mission's goals and significance, explaining the meaning of 'utilization flight 1' (UF-1) as opposed to an 'assembly flight'. She gives details on the payload (Starshine Satellite, Avian Development Facility, and Rafaello Multipurpose Logistics Module (MPLM)), her role in the rendezvous, docking, and undocking of the Endeavour Orbiter to the International Space Station (ISS), how she will participate in the unloading and reloading of the MPLM, and the way in which the old and new resident crews of ISS will exchanged. Godwin ends with her thoughts on the short-term and long-term future of the International Space Station.

STS-108 Crew Interviews: Dom Gorie

NASA Technical Reports Server (NTRS)

2001-01-01

STS-108 Commander Dom Gorie is seen during a prelaunch interview. He answers questions about the mission's goals and significance, explaining the meaning of 'utilization flight 1' (UF-1) as opposed to an 'assembly flight'. He gives details on the payload (Starshine Satellite, Avian Development Facility, and Rafaello Multipurpose Logistics Module (MPLM)), his role in the rendezvous, docking, and undocking of the Endeavour Orbiter to the International Space Station (ISS), how he will participate in the unloading and reloading of the MPLM, and the way in which the old and new resident crews of ISS will exchanged. Gorie ends with his thoughts on the short-term and long-term future of the International Space Station.

STS-108 Crew Interviews: Dan Tani

NASA Technical Reports Server (NTRS)

2001-01-01

STS-108 Mission Specialist Dan Tani is seen during a prelaunch interview. He answers questions about the mission's goals and significance, explaining the meaning of 'utilization flight 1' (UF-1) as opposed to an 'assembly flight'. He gives details on the payload (Starshine Satellite, Avian Development Facility, and Rafaello Multipurpose Logistics Module (MPLM)), his role in the rendezvous, docking, and undocking of the Endeavour Orbiter to the International Space Station (ISS), how he will participate in the unloading and reloading of the MPLM, and the way in which the old and new resident crews of ISS will exchanged. Tani ends with his thoughts on the short-term and long-term future of the International Space Station.

NASA Countermeasures Evaluation and Validation Project

NASA Technical Reports Server (NTRS)

Lundquist, Charlie M.; Paloski, William H. (Technical Monitor)

2000-01-01

To support its ISS and exploration class mission objectives, NASA has developed a Countermeasure Evaluation and Validation Project (CEVP). The goal of this project is to evaluate and validate the optimal complement of countermeasures required to maintain astronaut health, safety, and functional ability during and after short- and long-duration space flight missions. The CEVP is the final element of the process in which ideas and concepts emerging from basic research evolve into operational countermeasures. The CEVP is accomplishing these objectives by conducting operational/clinical research to evaluate and validate countermeasures to mitigate these maladaptive responses. Evaluation is accomplished by testing in space flight analog facilities, and validation is accomplished by space flight testing. Both will utilize a standardized complement of integrated physiological and psychological tests, termed the Integrated Testing Regimen (ITR) to examine candidate countermeasure efficacy and intersystem effects. The CEVP emphasis is currently placed on validating the initial complement of ISS countermeasures targeting bone, muscle, and aerobic fitness; followed by countermeasures for neurological, psychological, immunological, nutrition and metabolism, and radiation risks associated with space flight. This presentation will review the processes, plans, and procedures that will enable CEVP to play a vital role in transitioning promising research results into operational countermeasures necessary to maintain crew health and performance during long duration space flight.

Evaluation and prediction of long-term environmental effects on non metallic materials

NASA Technical Reports Server (NTRS)

Papazian, H.

1985-01-01

Predictive modeling of environmental conditions on nonmetallic materials was studied. The in-flight data of the atomic oxygen reaction with carbon and osmium, the laboratory and in-flight data of the atomic oxygen reaction with polymeric films and the effect of electron irradiation on the rates of oxidation are discussed. No information is found that can be used to model such effects on composites. The effects of the space environment on thermal control coatings and its effect on the space station are examined.

Modification of cytogenetic and physiological effects of space flight factors by biologically active compounds

NASA Technical Reports Server (NTRS)

Aliyev, A. A.; Mekhti-Zade, E. R.; Mashinskiy, A. L.; Alekperov, U. K.

1986-01-01

Physiological and cytogenetic changes in the Welsh onion plants induced by a short (82 days) and long term (522 days) space flight are expressed in decrease of seed germination, inhibition of stem growth, depression of cell division in root meristem, and increase in the number of structural chromosome rearrangements. The treatment of such plants with solutions of a-tocopherol, auxin, and kinetin decreased the level of chromosome aberrations to the control one and normalized cell divisions and growth partly or completely.

Oxygen regimen in the human peripheral tissue during space flights

NASA Astrophysics Data System (ADS)

Haase, H.; Kovalenko, E. A.; Vacek, A.; Bobrovnickij, M. P.; Jarsumbeck, B.; Semencov, V. N.; Sarol, Z.; Hideg, J.; Zlatarev, K.

A survey of the results of the experiment "Oxygen," carried out within the scope of the INTERKOSMOS program in members of the permanent crews and of international visiting expeditions to the Soviet orbital station Salyut-6, is given. During the 7-day space flights of the international visiting expeditions a significant decrease in pO 2 ic by 3.28 kPa was observed. Local oxygen utilization reduced significantly by 0.44 kPa. During hyperventilation testing after return to earth a statistically significant decrease in the peak value by 1.39 kPa was noted. In the long-term crews of the orbital station Salyut-6 the highest decrease in pO 2 ic of 3.8 kPa and the absolutely lowest value of 3.4 ± 0.5 kPa during space flight were observed. The decrease in local oxygen utilization during the flight of 0.8 kPa/min was greater than that of the visiting crews. The results indicate the importance of investigating the dynamics of the oxygen regimen for medical control of the crew members both during the space flight and during the readaptation phase after return to earth.

[A tracking function of human eye in microgravity and during readaptation to earth's gravity].

PubMed

Kornilova, L N

2001-01-01

The paper summarizes results of electro-oculography of all ways of visual tracking: fixative eye movements (saccades), smooth pursuit of linearly, pendulum-like and circularly moving point stimuli, pursuit of vertically moving foveoretinal optokinetic stimuli, and presents values of thresholds and amplification coefficients of the optokinetic nystagmus during tracking of linear movement of foveoretinal optokinetic stimuli. Investigations were performed aboard the Salyut and Mir space stations with participation of 31 cosmonauts of whom 27 made long-term (76 up to 438 day) and 4 made short-term (7 to 9 day) missions. It was shown that in space flight the saccadic structure within the tracking reaction does not change; yet, corrective movements (additional microsaccades to achieve tracking) appeared in 47% of observations at the onset and in 76% of observations on months 3 to 6 of space flight. After landing, the structure of vertical saccades was found altered in half the cosmonauts. No matter in or after flight, reverse nystagmus was present along with the gaze nystagmus during static saccades in 22% (7 cosmonauts) of the observations. Amplitude of tracking vertically, diagonally or circularly moving stimuli was significantly reduced as period on mission increased. Early in flight (40% of the cosmonauts) and shortly afterwards (21% of the cosmonauts) the structure of smooth tracking reaction was totally broken up, that is eye followed stimulus with micro- or macrosaccades. The structure of smooth eye tracking recovered on flight days 6-8 and on postflight days 3-4. However, in 46% of the cosmonauts on long-term missions the structure of smooth eye tracking was noted to be disturbed periodically, i.e. smooth tracking was replaced by saccadic.

Physiologic adaptation of man in space; Proceedings of the Seventh International Man in Space Symposium, Houston, TX, Feb. 10-13, 1986

NASA Technical Reports Server (NTRS)

Holland, Albert W. (Editor)

1987-01-01

Topics discussed in this volume include space motion sickness, cardiovascular adaptation, fluid shifts, extravehicular activity, general physiology, perception, vestibular response modifications, vestibular physiology, and pharmacology. Papers are presented on the clinical characterization and etiology of space motion sickness, ultrasound techniques in space medicine, fluid shifts in weightlessness, Space Shuttle inflight and postflight fluid shifts measured by leg volume changes, and the probability of oxygen toxicity in an 8-psi space suit. Consideration is also given to the metabolic and hormonal status of crewmembers in short-term space flights, adaptive changes in perception of body orientation and mental image rotation in microgravity, the effects of a visual-vestibular stimulus on the vestibulo-ocular reflex, rotation tests in the weightless phase of parabolic flight, and the mechanisms of antimotion sickness drugs.

Applied Physics Lab Kennedy Space Center: Recent Contributions

NASA Technical Reports Server (NTRS)

Starr, Stan; Youngquist, Robert

2006-01-01

The mission of the Applied Physics Lab is: (1) Develop and deliver novel sensors and devices to support KSC mission operations. (2) Analyze operational issues and recommend or deliver practical solutions. (3) Apply physics to the resolution of long term space flight issues that affect space port operation on Earth or on other planets.

Animals in biomedical space research

NASA Astrophysics Data System (ADS)

Phillips, Robert W.

The use of experimental animals has been a major component of biomedical research progress. Using animals in space presents special problems, but also provides special opportunities. Rat and squirrel monkeys experiments have been planned in concert with human experiments to help answer fundamental questions concerning the effect of weightlessness on mammalian function. For the most part, these experiments focus on identified changes noted in humans during space flight. Utilizing space laboratory facilities, manipulative experiments can be completed while animals are still in orbit. Other experiments are designed to study changes in gravity receptor structure and function and the effect of weightlessness on early vertebrate development. Following these preliminary animals experiments on Spacelab Shuttle flights, longer term programs of animal investigation will be conducted on Space Station.

Microbial Monitoring of Common Opportunistic Pathogens by Comparing Multiple Real-Time PCR Platforms for Potential Space Applications

NASA Technical Reports Server (NTRS)

Oubre, Cherie M.; Birmele, Michele N.; Castro, Victoria A.; Venkateswaran, Kasthuri J.; Vaishampayan, Parag A.; Jones, Kathy U.; Singhal, Adesh; Johnston, Angela S.; Roman, Monserrate C.; Ozbolt, Tamra A.;

Effects of long-term space condition on cell ultrastructure and the molecular level change of the tomato

NASA Astrophysics Data System (ADS)

Jinying, L.; Min, L.; Huai, X.; Yi, P.; Chunhua, Z.; Nechitalo, G.

Effects of long-term exposure to physical factors of space flight on dormant seeds were studied on plants derived from tomato seeds flown for 6 years on board of the space station MIR Upon return to the Earth the seeds were germinated and grown to maturity Samples of plants were compared to plants from parallel ground-based controls Various differences of ultrastructure of the tomato leaf cell were observed with an electron microscope One plant carried by space station has the anatomy of leaves with a three-layered palisade tissue and other plants similar with ground controls have the anatomy of leaves with a one-layered palisade tissue The number of starch grains per chloroplast of every space-treated tomato leaf increased significantly compared with that of the ground control The leaf cell walls of two plants carried by space station became contracted and deformed The size of chloroplast in some space-treated plants was larger and the lamellae s structure of some chloroplasts turned curvature and loose The results obtained point out to significant changes occurring on the molecular level among the space-flight treated seedlings and the ground control The leaves of plants were used for AFLP Amplification Fragment Length Polymorphism analysis For the first generation space-flight treated tomato plants among 64 pairs of primers used in this experiment 43 primers generated the same DNA bands type and 21 primers generated a different DNA band type 2582 DNA bands were produced among which 34 DNA bands were polymorphic with the percentage

Behavioral and health implications of civilian spaceflight.

PubMed

Wichman, Harvey A

2005-06-01

The current enthusiasm over the prospect of space tourism and the belief among many that such civilian spaceflight is imminent are characterized herein. There are many concerns about screening and certifying passengers for future spaceflight. Efforts by several organizations to propose such screening are cited. The problem with some of these proposals, which treat all types of spaceflight the same, is that they are so restrictive that too few people would be eligible for space travel to have a viable tourism industry. However, not all types of spaceflight are the same, so the distinctions between them need to be clarified. Of the five types of spaceflight described, one is proposed as the most likely to be the first significant phase of space tourism: long-term microgravity flight in low Earth orbit. But because of human problems with long-term exposure to microgravity, this phase requires rather conservative screening and extensive training. However, prior to discussing the passenger issues related to this early phase of space tourism, the reasons why Earth-like gravity, as well as microgravity, must be made available to spacefarers before space tourism can take place on a grand scale need to be explained. Finally, major passenger medical and behavioral issues of the first phase of orbital space tourism-long-term microgravity flight-are discussed.

Mercury Atomic Frequency Standards for Space Based Navigation and Timekeeping

NASA Technical Reports Server (NTRS)

Tjoelker, R. L.; Burt, E. A.; Chung, S.; Hamell, R. L.; Prestage, J. D.; Tucker, B.; Cash, P.; Lutwak, R.

2012-01-01

A low power Mercury Atomic Frequency Standard (MAFS) has been developed and demonstrated on the path towards future space clock applications. A self contained mercury ion breadboard clock: emulating flight clock interfaces, steering a USO local oscillator, and consuming approx 40 Watts has been operating at JPL for more than a year. This complete, modular ion clock instrument demonstrates that key GNSS size, weight, and power (SWaP) requirements can be achieved while still maintaining short and long term performance demonstrated in previous ground ion clocks. The MAFS breadboard serves as a flexible platform for optimizing further space clock development and guides engineering model design trades towards fabrication of an ion clock for space flight.

Space Nuclear Reactor Engineering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poston, David Irvin

We needed to find a space reactor concept that could be attractive to NASA for flight and proven with a rapid turnaround, low-cost nuclear test. Heat-pipe-cooled reactors coupled to Stirling engines long identified as the easiest path to near-term, low-cost concept.

Investigation of Desiccants and CO2 Sorbents for Advanced Exploration Systems 2015-2016

NASA Technical Reports Server (NTRS)

Cmarik, Gregory E.; Knox, Jim

2016-01-01

Advanced Environmental Control and Life Support System (ECLSS) design is critical for human space flight beyond Earth. Current systems enable extended missions in low-Earth orbit, but for deep-space missions, not only will astronauts be outside the reach of resupply operations from Earth but they will also need to handle malfunctions and compensate for the degradation of materials. These two daunting challenges must be overcome for long-term independent space flight. In order to solve the first, separation and reuse of onboard atmosphere components is required. Current systems utilize space vacuum to fully regenerate adsorbent beds, but this is not sustainable thus necessitating a closed-loop system. The second challenge stems from material and performance degradation due to operational cycling and on-board contaminants. This report will review the recent work by the ECLSS team at Marshall Space Flight Center towards overcoming these challenges by characterizing materials via novel methods for use in future systems.

Skeletal response to short-term weightlessness

NASA Technical Reports Server (NTRS)

Wronski, T. J.; Morey-Holton, E. R.

1986-01-01

Male Sprague Dawley rats were placed in orbit for 7 days aboard the space shuttle. Bone histomorphometry was performed in the long bones and lumbar vertebrae of flight rats and compared to data derived from ground based control rats. Trabecular bone mass was not altered during the first week of weightlessness. Strong trends were observed in flight rats for decreased periosteal bone formation in the tibial diaphysis, reduced osteoblast size in the proximal tibia, and decreased osteoblast surface and number in the lumbar vertebra. Histologic indices of bone resorption was relatively normal in flight rats. The results indicate that 7 day of weightlessness are not of sufficient duration to induce histologicaly detectable loss of trabecular bone in rats. However, cortical and trabecular bone formation appear to be diminished during the first week of space flight.

Computational aerothermodynamics

NASA Technical Reports Server (NTRS)

Deiwert, George S.

1989-01-01

Computational aerothermodynamics concerns the coupling of real gas effects with equations of motion to include thermochemical rate processes for chemical and energy exchange phenomena. These processes concern the creation and destruction of gas species by chemical reactions and the transfer of energy between the various species and between the various energy modes (e.g., translation, rotation, vibration, ionization, dissociation/recombination, etc.) of the species. To gain some insight into when such phenomena occur for current and future aerospace flight vehicles the author shows the flight regimes of some typical vehicles (e.g., Concord, aerospace plane, Space Shuttle, associated space transfer vehicles, Apollo entry vehicle, etc.) in terms of flight altitude and flight speed. Also indicated are regimes where chemical reactions such as dissociation and ionization are important and where nonequilibrium thermochemical phenomena are important.

Functional testing of space flight induced changes in tonic motor control by using limb-attached excitation and load devices

NASA Astrophysics Data System (ADS)

Gallasch, Eugen; Kozlovskaya, Inessa

2007-02-01

Long term space flights induce atrophy and contractile changes on postural muscles such effecting tonic motor control. Functional testing of tonic motor control structures is a challenge because of the difficulties to deliver appropriate test forces on crew members. In this paper we propose two approaches for functional testing by using limb attached loading devices. The first approach is based on a frequency and amplitude controllable moving magnet exciter to deliver sinusoidal test forces during limb postures. The responding limb deflection is recorded by an embedded accelerometer to obtain limb impedance. The second approach is based on elastic limb loading to evoke self-excited oscillations during arm extensions. Here the contraction force at the oscillation onset provides information about limb stiffness. The rationale for both testing approaches is based on Feldman's λ-model. An arm expander based on the second approach was probed in a 6-month MIR space flight. The results obtained from the load oscillations, confirmed that this device is well suited to capture space flight induced neuromuscular changes.

HyPlane for Space Tourism and Business Transportation

NASA Astrophysics Data System (ADS)

Savino, R.

In the present work a preliminary study on a small hypersonic airplane for a long duration space tourism mission is presented. It is also consistent with a point-to-point medium range (5000-6000 km) hypersonic trip, in the frame of the "urgent business travel" market segment. The main ideas is to transfer technological solutions developed for aeronautical and space atmospheric re-entry systems to the design of such a hypersonic airplane. A winged vehicle characterized by high aerodynamic efficiency and able to manoeuvre along the flight path, in all aerodynamic regimes encountered, is taken into consideration. Rocket-Based Combined Cycle and Turbine-Based Combined Cycle engines are investigated to ensure higher performances in terms of flight duration and range. Different flight-paths are also considered, including sub-orbital parabolic trajectories and steady state hypersonic cruise. The former, in particular, takes advantage of the high aerodynamic efficiency during the unpowered phase, in combination with a periodic engine actuation, to guarantee a long duration oscillating flight path. These trajectories offer Space tourists the opportunity of extended missions, characterized by repeated periods of low-gravity at altitudes high enough to ensure a wide view of the Earth from Space.

Space transportation systems within ESA programmes: Current status and perspectives

NASA Astrophysics Data System (ADS)

Delahais, Maurice

1993-03-01

An overview of the space transportation aspects of the ESA (European Space Agency) programs as they result from history, present status, and decisions taken at the ministerial level conference in Granada, Spain is presented. The new factors taken into consideration for the long term plan proposed in Munich, Germany, the three strategic options for the reorientation of the ESA long term plan, and the essential elements of space transportation in the Granada long term plan in three areas of space activities, scientific, and commercial launches with expendable launch vehicles, manned flight and in-orbit infrastructure, and future transportation systems are outlined. The new ESA long term plan, in the field of space transportation systems, constitutes a reorientation of the initial program contemplated in previous councils at ministerial level. It aims at balancing the new economic situation with the new avenues of cooperation, and the outcome will be a new implementation of the space transportation systems policy.

NASA's Space Launch Initiative Targets Toxic Propellants

NASA Technical Reports Server (NTRS)

Hurlbert, Eric; McNeal, Curtis; Davis, Daniel J. (Technical Monitor)

2001-01-01

When manned and unmanned space flight first began, the clear and overriding design consideration was performance. Consequently, propellant combinations of all kinds were considered, tested, and, when they lifted the payload a kilometer higher, or an extra kilogram to the same altitude, they became part of our operational inventory. Cost was not considered. And with virtually all of the early work being performed by the military, safety was hardly a consideration. After all, fighting wars has always been dangerous. Those days are past now. With space flight, and the products of space flight, a regular part of our lives today, safety and cost are being reexamined. NASA's focus turns naturally to its Shuttle Space Transportation System. Designed, built, and flown for the first time in the 1970s, this system remains today America's workhorse for manned space flight. Without its tremendous lift capability and mission flexibility, the International Space Station would not exist. And the Hubble telescope would be a monument to shortsighted management, rather than the clear penetrating eye on the stars it is today. But the Shuttle system fully represents the design philosophy of its period: it is too costly to operate, and not safe enough for regular long term access to space. And one of the key reasons is the utilization of toxic propellants. This paper will present an overview of the utilization of toxic propellants on the current Shuttle system.

Performance considerations in long-term spaceflight

NASA Technical Reports Server (NTRS)

Akins, F. R.

1979-01-01

Maintenance of skilled performance during extended space flight is of critical importance to both the health and safety of crew members and to the overall success of mission goals. An examination of long term effects and performance requirements is therefore a factor of immense importance to the planning of future missions. Factors that were investigated include: definition of performance categories to be investigated; methods for assessing and predicting performance levels; in-flight factors which can affect performance; and factors pertinent to the maintenance of skilled performance.

Calbindins decreased after space flight

NASA Technical Reports Server (NTRS)

Sergeev, I. N.; Rhoten, W. B.; Carney, M. D.

1996-01-01

Exposure of the body to microgravity during space flight causes a series of well-documented changes in Ca2+ metabolism, yet the cellular and molecular mechanisms leading to these changes are poorly understood. Calbindins, vitamin D-dependent Ca2+ binding proteins, are believed to have a significant role in maintaining cellular Ca2+ homeostasis. In this study, we used biochemical and immunocytochemical approaches to analyze the expression of calbindin-D28k and calbindin-D9k in kidneys, small intestine, and pancreas of rats flown for 9 d aboard the space shuttle. The effects of microgravity on calbindins in rats from space were compared with synchronous Animal Enclosure Module controls, modeled weightlessness animals (tail suspension), and their controls. Exposure to microgravity resulted in a significant and sustained decrease in calbindin-D28k content in the kidney and calbindin-D9k in the small intestine of flight animals, as measured by enzyme-linked immunosorbent assay (ELISA). Modeled weightlessness animals exhibited a similar decrease in calbindins by ELISA. Immunocytochemistry (ICC) in combination with quantitative computer image analysis was used to measure in situ the expression of calbindins in the kidney and the small intestine, and the expression of insulin in pancreas. There was a large decrease of immunoreactivity in renal distal tubular cell-associated calbindin-D28k and in intestinal absorptive cell-associated calbindin-D9k of space flight and modeled weightlessness animals compared with matched controls. No consistent difference in pancreatic insulin immunoreactivity between space flight, modeled weightlessness, and controls was observed. Regression analysis of results obtained by quantitative ICC and ELISA for space flight, modeled weightlessness animals, and their controls demonstrated a significant correlation. These findings after a short-term exposure to microgravity or modeled weightlessness suggest that a decreased expression of calbindins may contribute to the disorders of Ca2+ metabolism induced by space flight.

Flight Deck-Based Delegated Separation: Evaluation of an On-Board Interval Management System with Synthetic and Enhanced Vision Technology

NASA Technical Reports Server (NTRS)

Prinzel, Lawrence J., III; Shelton, Kevin J.; Kramer, Lynda J.; Arthur, Jarvis J.; Bailey, Randall E.; Norman, Rober M.; Ellis, Kyle K. E.; Barmore, Bryan E.

2011-01-01

An emerging Next Generation Air Transportation System concept - Equivalent Visual Operations (EVO) - can be achieved using an electronic means to provide sufficient visibility of the external world and other required flight references on flight deck displays that enable the safety, operational tempos, and visual flight rules (VFR)-like procedures for all weather conditions. Synthetic and enhanced flight vision system technologies are critical enabling technologies to EVO. Current research evaluated concepts for flight deck-based interval management (FIM) operations, integrated with Synthetic Vision and Enhanced Vision flight-deck displays and technologies. One concept involves delegated flight deck-based separation, in which the flight crews were paired with another aircraft and responsible for spacing and maintaining separation from the paired aircraft, termed, "equivalent visual separation." The operation required the flight crews to acquire and maintain an "equivalent visual contact" as well as to conduct manual landings in low-visibility conditions. The paper describes results that evaluated the concept of EVO delegated separation, including an off-nominal scenario in which the lead aircraft was not able to conform to the assigned spacing resulting in a loss of separation.

Technology Development for a Hyperspectral Microwave Atmospheric Sounder (HyMAS)

NASA Technical Reports Server (NTRS)

Blackwell, W.; Galbraith, C.; Hilliard, L.; Racette, P.; Thompson, E.

2014-01-01

The Hyperspectral Microwave Atmospheric Sounder (HyMAS) is being developed at Lincoln Laboratories and accommodated by the Goddard Space Flight Center for a flight opportunity on a NASA research aircraft. The term hyperspectral microwave is used to indicate an all-weather sounding instrument that performs equivalent to hyperspectral infrared sounders in clear air with vertical resolution of approximately 1 km. Deploying the HyMAS equipped scanhead with the existing Conical Scanning Microwave Imaging Radiometer (CoSMIR) shortens the path to a flight demonstration. Hyperspectral microwave is achieved through the use of independent RF antennas that sample the volume of the Earths atmosphere through various levels of frequencies, thereby producing a set of dense, spaced vertical weighting functions.

Role of CFD in propulsion design - Government perspective

NASA Technical Reports Server (NTRS)

Schutzenhofer, L. A.; Mcconnaughey, H. V.; Mcconnaughey, P. K.

1990-01-01

Various aspects of computational fluid dynamics (CFD), as it relates to design applications in rocket propulsion activities from the government perspective, are discussed. Specific examples are given that demonstrate the application of CFD to support hardware development activities, such as Space Shuttle Main Engine flight issues, and the associated teaming strategy used for solving such problems. In addition, select examples that delineate the motivation, methods of approach, goals and key milestones for several space flight progams are cited. An approach is described toward applying CFD in the design environment from the government perspective. A discussion of benchmark validation, advanced technology hardware concepts, accomplishments, needs, future applications, and near-term expectations from the flight-center perspective is presented.

Studies of social group dynamics under isolated conditions. Objective summary of the literature as it relates to potential problems of long duration space flight

NASA Technical Reports Server (NTRS)

Vinograd, S. P.

1974-01-01

Scientific literature which deals with the study of human behavior and crew interaction in situations simulating long term space flight is summarized and organized. A bibliography of all the pertinent U.S. literature available is included, along with definitions of the behavioral characteristics terms employed. The summarized studies are analyzed according to behavioral factors and environmental conditions. The analysis consist of two matrices. (1) The matrix of factors studied correlates each research study area and individual study with the behavioral factors that were investigated in the study. (2) The matrix of conclusions identifies those studies whose investigators appeared to draw specific conclusions concerning questions of importance to NASA.

Changes in mineral metabolism with immobilization/space flight

NASA Technical Reports Server (NTRS)

Gallagher, J. C.

1989-01-01

Researchers are still unsure of the accuracy of previous bone density measurements of their significance following a period of weightlessness. Rapid technological advances in the measurement of bone density will enable us now to measure bone density accurately at multiple sites in the skeleton with doses of radiation less than that given by a spine x ray. It may not be possible to obtain this type of information before the next series of space flights take place, although the bed-rest model may provide supporting information. Extensive testing of bone density on every astronaut should be performed before and after the space flight. Prevention and treatment can only be undertaken after gathering sufficient baseline information. The use of exercise in preventing bone loss is still highly speculative, but represents a relatively easy approach to the problem in terms of study.

Breast Cancer Research at NASA

NASA Technical Reports Server (NTRS)

1998-01-01

Isolation of human mammary epithelial cells (HMEC) from breast cancer susceptible tissue. Isolate of long-term growth human mammary epithelial cells (HMEC) from outgrowth of duct element; cells shown soon after isolation and early in culture in a dish. NASA's Marshall Space Flight Center (MSFC) is sponsoring research with Bioreactors, rotating wall vessels designed to grow tissue samples in space, to understand how breast cancer works. This ground-based work studies the growth and assembly of human mammary epithelial cell (HMEC) from breast cancer susceptible tissue. Radiation can make the cells cancerous, thus allowing better comparisons of healthy vs. tunorous tissue. Credit: Dr. Robert Tichmond, NASA/Marshall Space Flight Center (MSFC).

Microbial growth and physiology in space - A review

NASA Technical Reports Server (NTRS)

Cioletti, Louis A.; Mishra, S. K.; Pierson, Duane L.

1991-01-01

An overview of microbial behavior in closed environments is given with attention to data related to simulated microgravity and actual space flight. Microbes are described in terms of antibiotic sensitivity, subcellular structure, and physiology, and the combined effects are considered of weightlessness and cosmic radiation on human immunity to such microorganisms. Space flight results report such effects as increased phage induction, accelerated microbial growth rates, and the increased risk of disease communication and microbial exchange aboard confining spacecraft. Ultrastructural changes are also noted in the nuclei, cell membranes, and cytoplasmic streaming, and it appears that antibiotic sensitivity is reduced under both actual and simulated conditions of spaceflight.

Microgravity

NASA Image and Video Library

1998-10-10

Isolation of human mammary epithelial cells (HMEC) from breast cancer susceptible tissue. Isolate of long-term growth human mammary epithelial cells (HMEC) from outgrowth of duct element; cells shown soon after isolation and early in culture in a dish. NASA's Marshall Space Flight Center (MSFC) is sponsoring research with Bioreactors, rotating wall vessels designed to grow tissue samples in space, to understand how breast cancer works. This ground-based work studies the growth and assembly of human mammary epithelial cell (HMEC) from breast cancer susceptible tissue. Radiation can make the cells cancerous, thus allowing better comparisons of healthy vs. tunorous tissue. Credit: Dr. Robert Tichmond, NASA/Marshall Space Flight Center (MSFC).

Microgravity

NASA Image and Video Library

1998-10-10

Isolation of human mammary epithelial cells (HMEC) from breast cancer susceptible tissue. Outgrowth of cells from duct element in upper right corner cultured in a standard dish; most cells spontaneously die during early cell divisions, but a few will establish long-term growth. NASA's Marshall Space Flight Center (MSFC) is sponsoring research with Bioreactors, rotating wall vessels designed to grow tissue samples in space, to understand how breast cancer works. This ground-based work studies the growth and assembly of human mammary epithelial cell (HMEC) from breast cancer susceptible tissue. Radiation can make the cells cancerous, thus allowing better comparisons of healthy vs. tunorous tissue. Credit: Dr. Robert Tichmond, NASA/Marshall Space Flight Center (MSFC).

LSG_Broll

NASA Image and Video Library

2018-05-15

NASA engineers discussed the Life Sciences Glovebox, the agency's newest research facility for the International Space Station today at Marshall Space Flight Center in Huntsville, Alabama. The Life Sciences Glovebox will be used to study the long-term impact of microgravity on human physiology, revealing new ways to improve life on Earth while protecting human explorers during long-duration deep space missions.

Assessment of programs in space biology and medicine

NASA Technical Reports Server (NTRS)

1991-01-01

Over the past 30 or more years, the National Research Council Space Studies Board and its various committees have published hundreds of recommendations concerning life sciences research. Several particularly noteworthy themes appear consistently: (1) Balance - the need for a well-balanced research program in terms of ground versus flight, basic versus clinical, and internal versus extramural; (2) Excellence - because of the extremely limited number of flight opportunities (as well as their associated relative costs), the need for absolute excellence in the research that is conducted, in terms of topic, protocol, and investigator, and (3) Facilities - the single most important facility for life sciences research in space, an on-board, variable force centrifuge. In this first assessment report, the Committee on Space Biology and Medicine emphasizes that these long-standing themes remain as essential today as when first articulated. On the brink of the twenty-first century, the nation is contemplating the goal of human space exploration; consequently, the themes bear repeating. Each is a critical component of what will be necessary to successfully achieve such a goal.

Development and approach to low-frequency microgravity isolation systems

NASA Technical Reports Server (NTRS)

Grodsinsky, Carlos M.

1990-01-01

The low-gravity environment provided by space flight has afforded the science community a unique arena for the study of fundamental and technological sciences. However, the dynamic environment observed on space shuttle flights and predicted for Space Station Freedom has complicated the analysis of prior microgravity experiments and prompted concern for the viability of proposed space experiments requiring long-term, low-gravity environments. Thus, isolation systems capable of providing significant improvements to this random environment are being developed. The design constraints imposed by acceleration-sensitive, microgravity experiment payloads in the unique environment of space and a theoretical background for active isolation are discussed. A design is presented for a six-degree-of-freedom, active, inertial isolation system based on the baseline relative and inertial isolation techniques described.

Description of the meteoroid detection experiment flown on the Pioneer 10 and 11 Jupiter flyby missions

NASA Technical Reports Server (NTRS)

Oneal, R. L. (Compiler)

1974-01-01

The meteoroid detection experiment has the objective of measuring the population of 10 to the minus 9th power and 10 to the minus 8th power grams mass particles in interplanetary space with emphasis on making these measurements in the Asteroid Belt. The instrument design, which uses the pressurized-cell-penetration detection technique, and the tests involved in obtaining a flight-qualified instrument are described. The successful demonstration of flight-quality penetration detectors to function properly under long-term simulated space environments is also described.

The F-18 systems research aircraft facility

NASA Technical Reports Server (NTRS)

Sitz, Joel R.

1992-01-01

To help ensure that new aerospace initiatives rapidly transition to competitive U.S. technologies, NASA Dryden Flight Research Facility has dedicated a systems research aircraft facility. The primary goal is to accelerate the transition of new aerospace technologies to commercial, military, and space vehicles. Key technologies include more-electric aircraft concepts, fly-by-light systems, flush airdata systems, and advanced computer architectures. Future aircraft that will benefit are the high-speed civil transport and the National AeroSpace Plane. This paper describes the systems research aircraft flight research vehicle and outlines near-term programs.

Decreases in thymopoiesis of astronauts returning from space flight

PubMed Central

Benjamin, Cara L.; Stowe, Raymond P.; St. John, Lisa; Sams, Clarence F.; Mehta, Satish K.; Crucian, Brian E.; Pierson, Duane L.

2016-01-01

Following the advent of molecular assays that measure T cell receptor excision circles (TRECs) present in recent thymic emigrants, it has been conclusively shown that thymopoiesis persists in most adults, but that functional output decreases with age, influencing the maintenance of a diverse and functional T cell receptor (TCR) repertoire. Space flight has been shown to result in a variety of phenotypic and functional changes in human T cells and in the reactivation of latent viruses. While space flight has been shown to influence thymic architecture in rodents, thymopoiesis has not previously been assessed in astronauts. Here, we assessed thymopoiesis longitudinally over a 1-year period prior to and after long-term space flight (median duration, 184 days) in 16 astronauts. While preflight assessments of thymopoiesis remained quite stable in individual astronauts, we detected significant suppression of thymopoiesis in all subjects upon return from space flight. We also found significant increases in urine and plasma levels of endogenous glucocorticoids coincident with the suppression of thymopoiesis. The glucocorticoid induction and thymopoiesis suppression were transient, and they normalized shortly after return to Earth. This is the first report to our knowledge to prospectively demonstrate a significant change in thymopoiesis in healthy individuals in association with a defined physiologic emotional and physical stress event. These results suggest that suppression of thymopoiesis has the potential to influence the maintenance of the TCR repertoire during extended space travel. Further studies of thymopoiesis and endogenous glucocorticoids in other stress states, including illness, are warranted. PMID:27699228

The Application of Advanced Cultivation Techniques in the Long Term Maintenance of Space Flight Plant Biological Systems

NASA Technical Reports Server (NTRS)

Heyenga, A. G.

2003-01-01

The development of the International Space Station (ISS) presents extensive opportunities for the implementation of long duration space life sciences studies. Continued attention has been placed in the development of plant growth chamber facilities capable of supporting the cultivation of plants in space flight microgravity conditions. The success of these facilities is largely dependent on their capacity to support the various growth requirements of test plant species. The cultivation requirements for higher plant species are generally complex, requiring specific levels of illumination, temperature, humidity, water, nutrients, and gas composition in order to achieve normal physiological growth and development. The supply of water, nutrients, and oxygen to the plant root system is a factor, which has proven to be particularly challenging in a microgravity space flight environment. The resolution of this issue is particularly important for the more intensive crop cultivation of plants envisaged in Nasa's advanced life support initiative. BioServe Space Technologies is a NASA, Research Partnership Center (RPC) at the University of Colorado, Boulder. BioServe has designed and operated various space flight plant habitat systems, and placed specific emphasis on the development and enhanced performance of subsystem components such as water and nutrient delivery, illumination, gas exchange and atmosphere control, temperature and humidity control. The further development and application of these subsystems to next generation habitats is of significant benefit and contribution towards the development of both the Space Plant biology and the Advanced Life Support Programs. The cooperative agreement between NASA Ames Research center and BioServe was established to support the further implementation of advanced cultivation techniques and protocols to plant habitat systems being coordinated at NASA Ames Research Center. Emphasis was placed on the implementation of passive-based water and nutrient support systems and techniques, which can be used to minimize demands on power, mass, and operational complexity in space flight studies. This effort has direct application to the development of next-generation space flight plant chambers such as the Plant Research Unit (PRU). Work was also directed at the development of in-flight plant preservation techniques and protocols consistent with the interest in applying recent developments in gene chip micro array technologies. Cultivation technologies and protocols were evaluated in a 55 day space flight plant growth study, conducted on the ISS, mission 9A (10/7/02 - 12/7/02).

Space Science

NASA Image and Video Library

1999-04-21

NASA's Space Optics Manufacturing Center has been working to expand our view of the universe via sophisticated new telescopes. The Optics Center's goal is to develop low-cost, advanced space optics technologies for the NASA program in the 21st century - including the long-term goal of imaging Earth-like planets in distant solar systems. To reduce the cost of mirror fabrication, Marshall Space Flight Center (MSFC) has developed replication techniques, the machinery, and materials to replicate electro-formed nickel mirrors. The process allows fabricating precisely shaped mandrels to be used and reused as masters for replicating high-quality mirrors. Dr. Joe Ritter examines a replicated electro-formed nickel-alloy mirror which exemplifies the improvements in mirror fabrication techniques, with benefits such as dramtic weight reduction that have been achieved at the Marshall Space Flight Center's Space Optics Manufacturing Technology Center (SOMTC).

Earth Science Microwave Remote Sensing at NASA's Goddard Space Flight Center

NASA Technical Reports Server (NTRS)

Kim, Edward; Busalacchi, Antonio J. (Technical Monitor)

2000-01-01

The Goddard Space Flight Center (GSFC) was established as NASA's first space flight center in 1959. Its 12,000 personnel are active in the Earth and space sciences, astronomy, space physics, tracking and communications. GSFC's mission is to expand our knowledge of the Earth and its environment, the solar system, and the universe through observations from space. The main Goddard campus is located in Greenbelt, Maryland, USA, just north of Washington, D.C. The Wallops Flight Facility (operational since 1945), located on the Atlantic coast of Virginia was consolidated with the Goddard Space Flight Center in 1982. Wallops is now NASA's principal facility for management and implementation of suborbital research programs, and supports a wide variety of airborne science missions as well. As the lead Center for NASA's Earth Science Enterprise (ESE)--a long-term, coordinated research effort to study the Earth as a global environmental system--GSFC scientists and engineers are involved in a wide range of Earth Science remote sensing activities. Their activities range from basic geoscience research to the development of instruments and technology for space missions, as well as the associated Calibration/Validation (Cal/Val) work. The shear breadth of work in these areas precludes an exhaustive description here. Rather, this article presents selected brief overviews of microwave-related Earth Science applications and the ground-based, airborne, and space instruments that are in service, under development, or otherwise significantly involving GSFC. Likewise, contributing authors are acknowledged for each section, but the results and projects they describe represent the cumulative efforts of many persons at GSFC as well as at collaborating institutions. For further information, readers are encouraged to consult the listed websites and references.

Neuritogenesis: A model for space radiation effects on the central nervous system

NASA Technical Reports Server (NTRS)

Vazquez, M. E.; Broglio, T. M.; Worgul, B. V.; Benton, E. V.

1994-01-01

Pivotal to the astronauts' functional integrity and survival during long space flights are the strategies to deal with space radiations. The majority of the cellular studies in this area emphasize simple endpoints such as growth related events which, although useful to understand the nature of primary cell injury, have poor predictive value for extrapolation to more complex tissues such as the central nervous system (CNS). In order to assess the radiation damage on neural cell populations, we developed an in vitro model in which neuronal differentiation, neurite extension, and synaptogenesis occur under controlled conditions. The model exploits chick embryo neural explants to study the effects of radiations on neuritogenesis. In addition, neurobiological problems associated with long-term space flights are discussed.

NASA's Hypersonic Investment Area

NASA Technical Reports Server (NTRS)

Hueter, Uwe; Hutt, John; McClinton, Charles

2002-01-01

NASA has established long term goals for access to space. The third generation launch systems are to be fully reusable and operational around 2025. The goal for third-generation launch systems represents significant reduction in cost and improved safety over the current first generation system. The Advanced Space Transportation Office (ASTP) at NASA s Marshall Space Flight Center (MSFC) has the agency lead to develop space transportation technologies. Within ASTP, under the Hypersonic Investment Area (HIA), third generation technologies are being pursued in the areas of propulsion, airframe, integrated vehicle health management (IVHM), avionics, power, operations and system analysis. These technologies are being matured through research and both ground and flight-testing. This paper provides an overview of the HIA program plans and recent accomplishments.

The Role of Space Medicine in Management of Risk in Spaceflight

NASA Technical Reports Server (NTRS)

Clark, Jonathan B.

2001-01-01

The purpose of Space Medicine is to ensure mission success by providing quality and comprehensive health care throughout all mission phases to optimize crew health and performance and to prevent negative long-term health consequences. Space flight presents additional hazards and associated risks to crew health, performance, and safety. With an extended human presence in space it is expected that illness and injury will occur on orbit, which may present a significant threat to crew health and performance and to mission success. Maintaining crew health, safety and performance and preventing illness and injury are high priorities necessary for mission success and agency goals. Space flight health care should meet the standards of practice of evidence based clinical medicine. The function of Space Medicine is expected to meet the agency goals as stated in the 1998 NASA Strategic Plan and the priorities established by the Critical Path Roadmap Project. The Critical Path Roadmap Project is an integrated NASA cross-disciplinary strategy to assess, understand, mitigate, and manage the risks associated with long-term exposure to the space flight environment. The evidence based approach to space medicine should be standardized, objective process yielding expected results and establishing clinical practice standards while balancing individual risk with mission (programmatic) risk. The ability to methodically apply available knowledge and expertise to individual and mission health issues will ensure appropriate priorities are assigned and resources are allocated. NASA Space Medicine risk management process is a combined clinical and engineering approach. Competition for weight, power, volume, cost, and crew time must be balanced in making decisions about the care of individual crew with competing agency resources.

Handbook for handling and storage of nickel-cadmium batteries: Lessons learned

NASA Technical Reports Server (NTRS)

Ford, Floyd E.; Rao, Gopalakrishna M.; Yi, Thomas Y.

1994-01-01

The handbook provides guidelines for the handling and storage of conventional NiCd flight batteries. The guidelines are based on many years of experience with ground and in-flight handling of batteries. The overall goal is to minimize the deterioration and irreversible effects of improper handling of NiCd flight batteries on flight performance. A secondary goal is to provide the reader with an understanding, in nonanalytical terms, of the degradation mechanisms of NiCd cells and how these mechanisms are affected by improper ground handling of flight hardware. Section 2 provides the reader with a brief introduction to NiCd cells. The effects of the environment on NiCd batteries are discussed in Section 3, and Section 4 contains 12 guidelines for battery handling and storage with supporting rationale for each guideline. The appendix provides a synopsis of NiCd cell design and evolution over 30 years of space flight on Goddard Space Flight Center (GSFC) satellites, along with a chronological review of key events that influenced the design of NiCd cells being flown today.

Gravity, Calcium, and Bone: Update, 1989

NASA Technical Reports Server (NTRS)

Arnaud, Sara B.; Morey-Holton, Emily

1991-01-01

Some of the results of recent short-term flights and ground-based experiments that have contributed new insights into skeletal adaptation, calcium metabolism, and growth processes in 0 g, are highlighted. After 6 months in space, bone demineralization, invariably involving the os calcis, was found not to extend to the lumbar spine in 4 exercising cosmonauts. A flight experiment in the Space Shuttle crew has documented the early events in the calcium endocrine system during spaceflight. On the ground, brief and long-term bed rest studies of healthy volunteers in the head-down tile (HDT) model of weightlessness were completed. The skeleton of the adult male responds more rapidly to unloading than previously recognized. Regional changes in bone density can be quantified in only 30 days, are highly individual, and follow the direction of gravitational forces in the HDT model during inactivity. Bone biopsy results in healthy volunteers after bed rest differ from results in paraplegics from the same sampling site. Flight experiments in growing rats reveal changes in the composition of bone mineral and matrix in the femur postflight that were found to be highly regional and suggestive of an effect of gravity on mineral distribution. These observations may be relevant to the results from an earlier Cosmos flight where artificial gravity in space was found to maintain bone strength, but not to correct the radial growth deficit.

Early Flight Fission Test Facilities (EFF-TF) and Concepts That Support Near-Term Space Fission Missions

NASA Technical Reports Server (NTRS)

VanDyke, Melissa; Houts, Mike; Godfroy, Thomas; Martin, James

2003-01-01

Fission technology can enable rapid, affordable access to any point in the solar system. If fusion propulsion systems are to be developed to their full potential; however, near-term customers must be identified and initial fission systems successfully developed, launched, and utilized. Successful utilization will most likely occur if frequent, significant hardware-based milestones can be achieved throughout the program. If the system is designed to operate within established radiation damage and fuel burn up limits while simultaneously being designed to allow close simulation of heat from fission using resistance heaters, high confidence in fission system pe$ormance and lifetime can be attained through non-nuclear testing. Through demonstration of systems concepts (designed by DOE National Laboratories) in relevant environments, this philosophy has been demonstrated through hardware testing in the Early Flight Fission Test Facilities (EFF-TF) at the Marshall Space Flight Center. The EFF-TF is designed to enable very realistic non-nuclear testing of space fission systems. Ongoing research at the EFF-TF is geared towards facilitating research, development, system integration, and system utilization via cooperative efforts with DOE labs, industry, universities, and other NASA centers.

How HRP Research Results Contribute to Human Space Exploration Risk Mitigation

NASA Technical Reports Server (NTRS)

Lumpkins, S. B.; Mindock, J. A.

2014-01-01

In addition to the scientific value of publications derived from research, results from Human Research Program (HRP) research also support HRP’s goals of mitigating crew health and performance risks in space flight. Research results are used to build the evidence base characterizing crew health and performance risks, to support risk research plan development, to inform crew health and performance standards, and to provide technologies to programs for meeting those standards and optimizing crew health and performance in space. This talk will describe examples of how research results support these efforts. For example, HRP research results are used to revise or even create new standards for human space flight, which have been established to protect crew health and performance during flight, and prevent negative long-term health consequences due to space flight. These standards are based on the best available clinical and scientific evidence, as well as operational experience from previous space flight missions, and are reviewed as new evidence emerges. Research results are also used to update the HRP evidence base, which is comprised of a set of reports that provide a current record of the state of knowledge from research and operations for each of the defined human health and performance risks for future NASA exploration missions. A discussion of the role of evidence within the HRP architecture will also be presented. The scope of HRP research results extends well beyond publications, as they are used in several capacities to support HRP deliverables and, ultimately, the advancement of human space exploration beyond low-Earth orbit.

How HRP Research Results Contribute to Human Space Exploration Risk Mitigation

NASA Technical Reports Server (NTRS)

Lumpkins, Sarah; Mindock, Jennifer

2014-01-01

In addition to the scientific value of publications derived from research, results from Human Research Program (HRP) research also support HRP's goals of mitigating crew health and performance risks in space flight. Research results are used to build the evidence base characterizing crew health and performance risks, to support risk research plan development, to inform crew health and performance standards, and to provide technologies to programs for meeting those standards and optimizing crew health and performance in space. This talk will describe examples of how research results support these efforts. For example, HRP research results are used to revise or even create new standards for human space flight, which have been established to protect crew health and performance during flight, and prevent negative long-term health consequences due to space flight. These standards are based on the best available clinical and scientific evidence, as well as operational experience from previous space flight missions, and are reviewed as new evidence emerges. Research results are also used to update the HRP evidence base, which is comprised of a set of reports that provide a current record of the state of knowledge from research and operations for each of the defined human health and performance risks for future NASA exploration missions. A discussion of the role of evidence within the HRP architecture will also be presented. The scope of HRP research results extends well beyond publications, as they are used in several capacities to support HRP deliverables and, ultimately, the advancement of human space exploration beyond low-Earth orbit.

Biomedical Analyses of Mice Body Hair Exposed to Long-term Space Flight as a Compliment of Human Research

NASA Astrophysics Data System (ADS)

Mukai, Chiaki

Introduction: To understand the effect of space environment characterized by microgravity and radiation on protein and mineral metabolisms is important for developing the countermeasures to the adverse effects happening on the astronauts who stay long-term in space. Thus JAXA has started a human research to study the effects of long-term exposure in space flight on gene expression and mineral metabolism by analyzing astronaut's hair grown in space since December 2009 (Experiment nicknamed "HAIR"). Ten human subjects who are the crew of the International Space Station (ISS) will be expected to complete this experiment. Thanks to the tissue sharing program of space-flown mice which is presented and organized by AGI(Italian Space Agency), we can also have an opportunity to analyze rodents samples which will greatly compliment human hair experiment by enable us to conduct more detailed analysis with the expansion of skin analysis which is not include in human experiment. The purpose of this flown-mice experiment is to study the effects of long-term exposure to space environment such as microgravity and space radiation on mineral and protein metabolism, the biological responses to the stress levels, and the initial process of skin carcinogenesis by analyzing hair shaft, its root cells, and skin. Approach and Method In this experiment, we analyzed hair shaft, hair root and skin. Hair samples with skin were taken from 3-month space-flown mice and ground-control mice in the AGI's tissue sharing program in 2009. The sample numbers of space-flown mice and control-mice were three and six, respectively. And they were at the Mice Drawer System (MDS) in ISS and in the laboratory of Geneva University. For the hair shaft, the mineral balance is investi-gated by energy dispersive X-ray spectroscopy (SEM-EDX). For hair root, the extracted RNA undergoes DNA microarray analysis, and will be further examined particular interests of gene-expression by real time Reverse Transcription Polymerase Chain Reaction (RT-PCR) method. DNA is also extracted from the same samples and mitochondrial DNA copy numbers are ex-amined. For mice skin, the examination of the mutation was performed to investigate whether the space flight will cause the visible mutation which may reflect an evidence of promotion step of carcinogenesis by space radiation. Result: Analysis on the specimen is in progress. A brief results will be introduced during the COSPAR meeting. The mice body hair analysis will give us basic information to understand how space environment such as microgravity and radiation affect on the living organisms.

Description of the microbial ecology evaluation device, flight equipment, and ground transporter

NASA Technical Reports Server (NTRS)

Chassay, C. E.; Taylor, G. R.

1973-01-01

Exposure of test systems in space required the fabrication of specialized hardware termed a Microbial Ecology Evaluation Device that had individual test chambers and a complex optical filter system. The characteristics of this device and the manner in which it was deployed in space are described.

Space Science

NASA Image and Video Library

1992-03-24

Space Shuttle Atlantis (STS-45) onboard photo of Mission Specialist Kathryn Sullivan working in the Atmospheric Laboratory for Applications and Science (Atlas-1) module. Atlas-1 flew in a series of Spacelab flights that measured long term variability in the total energy radiated by the Sun and determined the variability in the solar spectrum.

Automated Long - Term Scheduling for the SOFIA Airborne Observatory

NASA Technical Reports Server (NTRS)

Civeit, Thomas

2013-01-01

The NASA Stratospheric Observatory for Infrared Astronomy (SOFIA) is a joint US/German project to develop and operate a gyro-stabilized 2.5-meter telescope in a Boeing 747SP. SOFIA's first science observations were made in December 2010. During 2011, SOFIA accomplished 30 flights in the "Early Science" program as well as a deployment to Germany. The new observing period, known as Cycle 1, is scheduled to begin in 2012. It includes 46 science flights grouped in four multi-week observing campaigns spread through a 13-month span. Automation of the flight scheduling process offers a major challenge to the SOFIA mission operations. First because it is needed to mitigate its relatively high cost per unit observing time compared to space-borne missions. Second because automated scheduling techniques available for ground-based and space-based telescopes are inappropriate for an airborne observatory. Although serious attempts have been made in the past to solve part of the problem, until recently mission operations staff was still manually scheduling flights. We present in this paper a new automated solution for generating SOFIA long-term schedules that will be used in operations from the Cycle 1 observing period. We describe the constraints that should be satisfied to solve the SOFIA scheduling problem in the context of real operations. We establish key formulas required to efficiently calculate the aircraft course over ground when evaluating flight schedules. We describe the foundations of the SOFIA long-term scheduler, the constraint representation, and the random search based algorithm that generates observation and instrument schedules. Finally, we report on how the new long-term scheduler has been used in operations to date.

Microgravity

NASA Image and Video Library

1998-10-10

Isolation of human mammary epithelial cells (HMEC) from breast cancer susceptible tissue; A: Duct element recovered from breast tissue digest. B: Outgrowth of cells from duct element in upper right corner cultured in a standard dish; most cells spontaneousely die during early cell divisions, but a few will establish long-term growth. C: Isolate of long-term frowth HMEC from outgrowth of duct element; cells shown soon after isolation and in early full-cell contact growth in culture in a dish. D: same long-term growth HMEC, but after 3 weeks in late full-cell contact growth in a continuous culture in a dish. Note attempts to reform duct elements but this in two demensions in a dish rather than in three dimensions in tissue. NASA's Marshall Space Flight Center (MSFC) is sponsoring research with Bioreactors, rotating wall vessels designed to grow tissue samples in space, to understand how breast cancer works. This ground-based work studies the growth and assembly of human mammary epithelial cell (HMEC) from breast cancer susceptible tissue. Radiation can make the cells cancerous, thus allowing better comparisons of healthy vs. tunorous tissue. Credit: Dr. Robert Richmond, NASA/Marshall Space Flight Center (MSFC).

OH Vision Test

NASA Image and Video Library

2014-06-03

ISS040-E-006739 (3 June 2014) --- European Space Agency astronaut Alexander Gerst, Expedition 40 flight engineer, uses the Optical Coherence Tomography (OCT) camera during an Ocular Health (OH) vision test in the Harmony node of the International Space Station. The OH experiment observes and seeks to understand vision changes during long-term space missions. NASA astronaut Steve Swanson (left), Expedition 40 commander, assists Gerst.

Artificial gravity: Phyiological perspectives for long-term space exploration

NASA Astrophysics Data System (ADS)

di Prampero, P.; Antonutto, G.

2005-08-01

We suggested previously the Twin Bike System (TBS) as a possible countermeasure to prevent cardiovascular deconditioning during long term space flight. The TBS consists of two bicycles, operated by the astronauts, moving at the very same speed, but in the opposite sense, along the inner wall of a cylindrical space module, thus generating a centrifugal acceleration vector, mimicking gravity. To gain some insight on the effectiveness of the TBS we hereby propose a similar approach (the Mono Bike System, MBS) to be tested during bed rest on Earth.

Cardiovascular dynamics during space sickness and deconditioning

NASA Technical Reports Server (NTRS)

Goldberger, Ary L.; Rigney, David R.

1991-01-01

We are currently funded by NASA for the project, 'Cardiovascular Dynamics During Space Sickness and Deconditioning.' NASA has given priority to the investigation of two problems encountered in the long-term space flights currently being planned: (1) space motion sickness; and (2) cardiovascular deconditioning. We have proposed to use spectral and nonlinear dynamical analysis of heart rate data to quantify the presence of these problems and to evaluate countermeasures against them.

Electrically Driven Thermal Management: Flight Validation, Experiment Development, Future Technologies

NASA Technical Reports Server (NTRS)

Didion, Jeffrey R.

2018-01-01

Electrically Driven Thermal Management is an active research and technology development initiative incorporating ISS technology flight demonstrations (STP-H5), development of Microgravity Science Glovebox (MSG) flight experiment, and laboratory-based investigations of electrically based thermal management techniques. The program targets integrated thermal management for future generations of RF electronics and power electronic devices. This presentation reviews four program elements: i.) results from the Electrohydrodynamic (EHD) Long Term Flight Demonstration launched in February 2017 ii.) development of the Electrically Driven Liquid Film Boiling Experiment iii.) two University based research efforts iv.) development of Oscillating Heat Pipe evaluation at Goddard Space Flight Center.

Ground-Based Studies of Headward Fluid Shifts Related to Space Flight

NASA Technical Reports Server (NTRS)

Petersen, L. G.; Watkins, W.; Hargens, A. R.; Macias, B. R.

2017-01-01

Long-term space flight decreases visual acuity in more than 50% of astronauts with some reports of post-flight lumbar opening pressures up to 21 mmHg1. Loss of hydrostatic (gravitational) pressures in microgravity shifts blood, spinal fluid and tissue fluids towards the head, probably causing venous congestion and leading to symptoms compatible with chronically increased intracranial pressure (ICP). This is characterized as the Visual Impairment and Intracranial Pressure (VIIP) syndrome. Simulation of gravitational stress by application of Lower Body Negative Pressure (LBNP) is proposed as a means to reduce ICP and reestablish cerebral health in astronauts during long mission stay in space. We hypothesize that 50 mmHg of lower body negative pressure (LBNP) during supine and simulated intracranial hypertension by 15 deg head-down tilt (HDT) counteracts elevations in ICP and internal jugular vein crosssectional area (IJV CSA).

The role of a space patrol of solar X-ray radiation in the provisioning of the safety of orbital and interplanetary manned space flights

NASA Astrophysics Data System (ADS)

Avakyan, S. V.; Kovalenok, V. V.; Savinykh, V. P.; Ivanchenkov, A. S.; Voronin, N. A.; Trchounian, A.; Baranova, L. A.

2015-04-01

In interplanetary flight, after large solar flares, cosmonauts are subjected to the action of energetic solar protons and electrons. These energetic particles have an especially strong effect during extravehicular activity or (in the future) during residence on the surface of Mars, when they spend an extended time there. Such particles reach the orbits of the Earth and of Mars with a delay of several hours relative to solar X-rays and UV radiation. Therefore, there is always time to predict their appearance, in particular, by means of an X-ray-UV radiometer from the apparatus complex of the Space Solar Patrol (SSP) that is being developed by the co-authors of this paper. The paper discusses the far unexplored biophysical problem of manned flight to Mars, scheduled for the next decade. In long-term manned space flights on the orbital stations "Salyut" Soviet cosmonaut crews from three of the co-authors (cosmonauts V.V. Kovalenok, A.S. Ivanchenkov, and V.P. Savinykh) had repeatedly observed the effect of certain geophysical conditions on the psychological state of each crew. These effects coincide with the increased intensity of global illumination in the upper ionosphere space on flight altitudes (300-360 km). It is important that during all of these periods, most of the geomagnetic pulsations were completely absent. Possible ways to study the synergistic effects of the simultaneous absence of the geomagnetic field, the magnetic pulsations and the microwave radiation of the terrestrial ionosphere are considered for a flight to Mars.

Potential of balloon payloads for in flight validation of direct and nulling interferometry concepts

NASA Astrophysics Data System (ADS)

Demangeon, Olivier; Ollivier, Marc; Le Duigou, Jean-Michel; Cassaing, Frédéric; Coudé du Foresto, Vincent; Mourard, Denis; Kern, Pierre; Lam Trong, Tien; Evrard, Jean; Absil, Olivier; Defrere, Denis; Lopez, Bruno

2010-07-01

While the question of low cost / low science precursors is raised to validate the concepts of direct and nulling interferometry space missions, balloon payloads offer a real opportunity thanks to their relatively low cost and reduced development plan. Taking into account the flight capabilities of various balloon types, we propose in this paper, several concepts of payloads associated to their flight plan. We also discuss the pros and cons of each concepts in terms of technological and science demonstration power.

Columbia: The first five flights entry heating data series. Volume 2: The OMS Pod

NASA Technical Reports Server (NTRS)

Williams, S. D.

1983-01-01

Entry heating flight data and wind tunnel data on the OMS Pod are presented for the first five flights of the Space Shuttle Orbiter. The heating rate data are presented in terms of normalized film heat transfer coefficients as a function of angle-of-attack, Mach number, and normal shock Reynolds number. The surface heating rates and temperatures were obtained via the JSC NONLIN/INVERSE computer program. Time history plots of the surface heating rates and temperatures are also presented.

Proteome-wide Adaptations of Mouse Skeletal Muscles during a Full Month in Space.

PubMed

Tascher, Georg; Brioche, Thomas; Maes, Pauline; Chopard, Angèle; O'Gorman, Donal; Gauquelin-Koch, Guillemette; Blanc, Stéphane; Bertile, Fabrice

2017-07-07

The safety of space flight is challenged by a severe loss of skeletal muscle mass, strength, and endurance that may compromise the health and performance of astronauts. The molecular mechanisms underpinning muscle atrophy and decreased performance have been studied mostly after short duration flights and are still not fully elucidated. By deciphering the muscle proteome changes elicited in mice after a full month aboard the BION-M1 biosatellite, we observed that the antigravity soleus incurred the greatest changes compared with locomotor muscles. Proteomics data notably suggested mitochondrial dysfunction, metabolic and fiber type switching toward glycolytic type II fibers, structural alterations, and calcium signaling-related defects to be the main causes for decreased muscle performance in flown mice. Alterations of the protein balance, mTOR pathway, myogenesis, and apoptosis were expected to contribute to muscle atrophy. Moreover, several signs reflecting alteration of telomere maintenance, oxidative stress, and insulin resistance were found as possible additional deleterious effects. Finally, 8 days of recovery post flight were not sufficient to restore completely flight-induced changes. Thus in-depth proteomics analysis unraveled the complex and multifactorial remodeling of skeletal muscle structure and function during long-term space flight, which should help define combined sets of countermeasures before, during, and after the flight.

[Some magnetic-biological problems of distant and long-term space flights].

PubMed

Trukhanov, K A

2003-01-01

Some magnetobiological problems of orbital (in the geomagnetic field--GMF) and interplanetary (in hypomagnetic conditions) flights are considered. The influence of electromagnetic fields (EMF) created by systems and equipment of the space vehicle (SV) are touched also. A level of the geomagnetic field (GMF) onboard during the orbital flights is discussed. Its periodic variations onboard owing to movement of SV on an orbit are analyzed. The reader's attention in attracted to the papers by R.M. Baevsky et al. in which the influence of magnetic storms and periodic variations of GMS on the cardiovascular system of astronauts onboard are shown. Possible ways and mechanisms of the influence are discussed. The wrong assertions in a number of works namely that at orbital flights an appreciable electrical field is induced in an organism of an astronaut in a space-craft and the electrical field may by responsible for some biological impacts are analyzed. The situation at the future in the terplanetary flights (for example Martian missions) when a crew and biological objects for a long time will be in the interplanetary magnetic field (by several orders less then GMF) is considered. As applied to the flights the opportunities of generation onboard the "artificial" GMF are outlined. The ensuing biological and technical questions are discussed.

Breast Cancer Research at NASA

NASA Technical Reports Server (NTRS)

1998-01-01

Isolation of human mammary epithelial cells (HMEC) from breast cancer susceptible tissue. Outgrowth of cells from duct element in upper right corner cultured in a standard dish; most cells spontaneously die during early cell divisions, but a few will establish long-term growth. NASA's Marshall Space Flight Center (MSFC) is sponsoring research with Bioreactors, rotating wall vessels designed to grow tissue samples in space, to understand how breast cancer works. This ground-based work studies the growth and assembly of human mammary epithelial cell (HMEC) from breast cancer susceptible tissue. Radiation can make the cells cancerous, thus allowing better comparisons of healthy vs. tunorous tissue. Credit: Dr. Robert Tichmond, NASA/Marshall Space Flight Center (MSFC).

Breast Cancer Research at NASA

NASA Technical Reports Server (NTRS)

1998-01-01

Isolation of human mammary epithelial cells (HMEC) from breast cancer susceptible tissue. Same long-term growth human mammary epithelial cells (HMEC), but after 3 weeks in concinuous culture. Note attempts to reform duct elements, but this time in two dimensions in a dish rather that in three demensions in tissue. NASA's Marshall Space Flight Center (MSFC) is sponsoring research with Bioreactors, rotating wall vessels designed to grow tissue samples in space, to understand how breast cancer works. This ground-based work studies the growth and assembly of human mammary epithelial cell (HMEC) from breast cancer susceptible tissue. Radiation can make the cells cancerous, thus allowing better comparisons of healthy vs. tunorous tissue. Credit: Dr. Robert Tichmond, NASA/Marshall Space Flight Center (MSFC).

Tissue Engineering Organs for Space Biology Research

NASA Technical Reports Server (NTRS)

Vandenburgh, H. H.; Shansky, J.; DelTatto, M.; Lee, P.; Meir, J.

1999-01-01

Long-term manned space flight requires a better understanding of skeletal muscle atrophy resulting from microgravity. Atrophy most likely results from changes at both the systemic level (e.g. decreased circulating growth hormone, increased circulating glucocorticoids) and locally (e.g. decreased myofiber resting tension). Differentiated skeletal myofibers in tissue culture have provided a model system over the last decade for gaining a better understanding of the interactions of exogenous growth factors, endogenous growth factors, and muscle fiber tension in regulating protein turnover rates and muscle cell growth. Tissue engineering these cells into three dimensional bioartificial muscle (BAM) constructs has allowed us to extend their use to Space flight studies for the potential future development of countermeasures.

Microgravity

NASA Image and Video Library

1998-10-10

Isolation of human mammary epithelial cells (HMEC) from breast cancer susceptible tissue. Same long-term growth human mammary epithelial cells (HMEC), but after 3 weeks in concinuous culture. Note attempts to reform duct elements, but this time in two dimensions in a dish rather that in three demensions in tissue. NASA's Marshall Space Flight Center (MSFC) is sponsoring research with Bioreactors, rotating wall vessels designed to grow tissue samples in space, to understand how breast cancer works. This ground-based work studies the growth and assembly of human mammary epithelial cell (HMEC) from breast cancer susceptible tissue. Radiation can make the cells cancerous, thus allowing better comparisons of healthy vs. tunorous tissue. Credit: Dr. Robert Tichmond, NASA/Marshall Space Flight Center (MSFC).

Experimental program to determine long term characteristics of the MDE pressure transducers

NASA Technical Reports Server (NTRS)

Parker, C. D.

1973-01-01

The pressure cell sensors developed for the Pioneer 10/G meteoroid detection experiments (MDE) were investigated to enhance their application and their potential as a sensor in other MDE applications. Their Paschen characteristics were also investigated, and the effects of variations in geometry, Ni-63 platings (for initial ionizations) and sealing pressures were determined. The effects of extensive pre-flight testing and proton and heavy ion space radiation were investigated. Flight-quality pressure panels/cells were committed to long term testing to demonstrate their suitability for the Pioneer 10/G Missions.

Experimentation for the Maturation of Deep Space Cryogenic Refueling Technologies

NASA Technical Reports Server (NTRS)

Chato, David J.

2008-01-01

This report describes the results of the "Experimentation for the Maturation of Deep Space Cryogenic Refueling Technology" study. This study identifies cryogenic fluid management technologies that require low-gravity flight experiments bring technology readiness levels to 5 to 6; examines many possible flight experiment options; and develops near-term low-cost flight experiment concepts to mature the core technologies. A total of 25 white papers were prepared by members of the project team in the course of this study. The full text of each white paper is included and 89 relevant references are cited. The team reviewed the white papers that provided information on new or active concepts of experiments to pursue and assessed them on the basis of technical need, cost, return on investment, and flight platform. Based on on this assessment the "Centaur Test Bed for Cryogenic Fluid Management" was rated the highest. "Computational Opportunities for Cryogenics for Cryogenic and Low-g Fluid Systems" was ranked second, based on its high scores in state of the art and return on investment, even though scores in cost and time were second to last. "Flight Development Test Objective Approach for In-space Propulsion Elements" was ranked third.

Poster Session

NASA Technical Reports Server (NTRS)

1997-01-01

In this session, Poster Session, the discussion focuses on the following topics: Development of correlative measures for the assessment of attention and memory; Biodynamical Responses of the Crewmember Head/Neck System During Emergence Ejection; Fecundation in the Sky, a Ten Years Old Experiment in Microgravity; A Modified Botex Incubator as a Transport System For Developing Crickets into Space; Chromosomal Aberrations in Peripheral Lymphocytes of Cosmonauts and Astronauts after Space Flights; Method for Establishing Long term Bone Marrow; Cultures Under Microgravity Conditions Reproduction Under Simulated Weightlessness --Mammalian in vivo Experiments Under Suspension; Towards Human Movement Analysis Without the Use of Markers; Habitability Requirements For a Cogent Mars Mission; The Saucer Concept for Space Habitats; New Way In Modeling the Growth of the Organism; The Fractionation of Hydrogen and Oxygen Stable Isotopes By Life Support Systems of Space Station "MIR"; and Effect of Space Flight on Neutrophil Function.

The NASA Space Radiation Health Program

NASA Technical Reports Server (NTRS)

Schimmerling, W.; Sulzman, F. M.

1994-01-01

The NASA Space Radiation Health Program is a part of the Life Sciences Division in the Office of Space Science and Applications (OSSA). The goal of the Space Radiation Health Program is development of scientific bases for assuring adequate radiation protection in space. A proposed research program will determine long-term health risks from exposure to cosmic rays and other radiation. Ground-based animal models will be used to predict risk of exposures at varying levels from various sources and the safe levels for manned space flight.

Space Station

NASA Image and Video Library

1981-12-01

During 1980 and the first half of 1981, the Marshall Space Flight Center conducted studies concerned with a relatively low-cost, near-term, manned space platform to satisfy current user needs, yet capable of evolutionary growth to meet future needs. The Science and Application Manned Space Platform (SAMSP) studies were to serve as a test bed for developing scientific and operational capabilities required by later, more advanced manned platforms while accomplishing early science and operations. This concept illustrates a manned space platform.

Flight Development for Cryogenic Fluid Management in Support of Exploration Missions

NASA Technical Reports Server (NTRS)

Chato, David J.

2006-01-01

This paper describes the results of the "Experimentation for the Maturation of Deep Space Cryogenic Refueling Technology" study. The purposes of this study were to identify cryogenic fluids management technologies requiring low gravity flight experiments to bring to technology readiness level (TRL) 5-6; to study many possible flight experiment options; and to develop near-term low-cost flight experiment concepts to mature core technologies of refueling. A total of twenty-five white papers were prepared in the course of this study. Each white paper is briefly summarized and relevant references cited. A total of 90 references are cited.

Potential commercial use of the International Space Station by the biotechnology/pharmaceutical/biomedical sector

NASA Astrophysics Data System (ADS)

Morgenthaler, George W.; Stodieck, Louis

1999-01-01

The International Space Station (ISS) is the linch-pin of NASA's future space plans. It emphasizes scientific research by providing a world-class scientific laboratory in which to perform long-term basic science experiments in the space environment of microgravity, radiation, vacuum, vantage-point, etc. It will serve as a test-bed for determining human system response to long-term space flight and for developing the life support equipment necessary for NASA's Human Exploration and Development of Space (HEDS) enterprise. The ISS will also provide facilities (up to 30% of the U.S. module) for testing material, agricultural, cellular, human, aquatic, and plant/animal systems to reveal phenomena heretofore shrouded by the veil of 1-g. These insights will improve life on Earth and will provide a commercial basis for new products and services. In fact, some products, e.g., rare metal-alloys, semiconductor chips, or protein crystals that cannot now be produced on Earth may be found to be sufficiently valuable to be manufactured on-orbit. Biotechnology, pharmaceutical and biomedical experiments have been regularly flown on 10-16 day Space Shuttle flights and on three-month Mir flights for basic science knowledge and for life support system and commercial product development. Since 1985, NASA has created several Commercial Space Centers (CSCs) for the express purpose of bringing university, government and industrial researchers together to utilize space flight and space technology to develop new industrial products and processes. BioServe Space Technologies at the University of Colorado at Boulder and Kansas State University, Manhattan, Kansas, is such a NASA sponsored CSC that has worked with over 65 companies and institutions in the Biotech Sector in the past 11 years and has successfully discovered and transferred new product and process information to its industry partners. While tests in the space environment have been limited to about two weeks on Shuttle or a few months on Mir, tests on ISS can be performed over many months, or even years. More importantly, a test can be regularly scheduled so that the effects of microgravity and other space environment parameters can be thoroughly researched and quantified. This paper attempts to envision the potential benefits of this soon-to-be-available orbital laboratory and the broad commercial utilization of ISS that will likely occur.

Life of Pennzane and 815Z-Lubricated Instrument Bearings Cleaned with Non-CFC Solvents

NASA Technical Reports Server (NTRS)

Loewenthal, Stuart; Jones, William; Predmore, Roamer

1999-01-01

This report takes the form of two papers: (1) "Life of Pennzane and 815Z-Lubricated Instrument Bearings cleaned with Non-CFC Solvents" and (2) a published paper, entitled "Instrument bearing life with NON-CFC cleaners". Abstract for paper # 1 : Bearings used in spacecraft mechanisms have historically been cleaned with chlorofluorocarbon CFC-1 13 (Freon) solvents and lubricated with a perfluorinated polyalkylether (PFPE) oils like 815-Z. Little full-scale bearing life test data exists to evaluate the effects of the newer class environmental-friendly bearing cleaners or improved synthetic hydrocarbon space oils like Pennzane. To address the lack of data, a cooperative, bearing life test program was initiated between NASA, Lockheed Martin and MPB. The objective was to obtain comparative long-term, life test data for flight-quality bearings, cleaned with non-CFC solvents versus CFC-1 13 under flight-like conditions with two space oils. A goal was to gain a better understanding of the lubricant surface chemistry effects with such solvents. A second objective was to obtain well-controlled, full-scale bearing life test data with a relatively new synthetic oil (Pennzane), touted as an improvement to Bray 815Z, an oil with considerable space flight history. The second paper, which serves as an attachment, is abstracted below: Bearings used in spacecraft mechanisms have historically been cleaned with chlorofluorocarbon CFC-113 (Freon) solvents and lubricated with a perfluorinated polyalkylether (PFPE) oils like 815-Z. Little full-scale bearing life test data exists to evaluate the effects of the newer class environmental-friendly bearing cleaners or improved synthetic hydrocarbon space oils like Pennzane. To address the lack of data, a cooperative, bearing life test program was initiated between NASA, Lockheed Martin and MPB. The objective was to obtain comparative long-term, life test data for flight-quality bearings, cleaned with non-CFC solvents versus CFC-1 13 under flight-like conditions with two space oils. A goal was to gain a better understanding of the lubricant surface chemistry effects with such solvents. A second objective was to obtain well-controlled, full-scale bearing life test data with a relatively new synthetic oil (Pennzane), touted as an improvement to Bray 815Z, an oil with considerable space flight history.

INSPACE CHEMICAL PROPULSION SYSTEMS AT NASA's MARSHALL SPACE FLIGHT CENTER: HERITAGE AND CAPABILITIES

NASA Technical Reports Server (NTRS)

McRight, P. S.; Sheehy, J. A.; Blevins, J. A.

2005-01-01

NASA s Marshall Space Flight Center (MSFC) is well known for its contributions to large ascent propulsion systems such as the Saturn V rocket and the Space Shuttle external tank, solid rocket boosters, and main engines. This paper highlights a lesser known but very rich side of MSFC-its heritage in the development of in-space chemical propulsion systems and its current capabilities for spacecraft propulsion system development and chemical propulsion research. The historical narrative describes the flight development activities associated with upper stage main propulsion systems such as the Saturn S-IVB as well as orbital maneuvering and reaction control systems such as the S-IVB auxiliary propulsion system, the Skylab thruster attitude control system, and many more recent activities such as Chandra, the Demonstration of Automated Rendezvous Technology (DART), X-37, the X-38 de-orbit propulsion system, the Interim Control Module, the US Propulsion Module, and multiple technology development activities. This paper also highlights MSFC s advanced chemical propulsion research capabilities, including an overview of the center s Propulsion Systems Department and ongoing activities. The authors highlight near-term and long-term technology challenges to which MSFC research and system development competencies are relevant. This paper concludes by assessing the value of the full range of aforementioned activities, strengths, and capabilities in light of NASA s exploration missions.

NASA's Spaceliner 100 Investment Area Technology Activities

NASA Technical Reports Server (NTRS)

Hueter, Uwe; Lyles, Garry M. (Technical Monitor)

2001-01-01

NASA's has established long term goals for access-to-space. The third generation launch systems are to be fully reusable and operational around 2025. The goals for the third generation launch system are to reduce cost by a factor of 100 and improve safety by a factor of 10,000 over current conditions. The Advanced Space Transportation Program Office (ASTP) at the NASA's Marshall Space Flight Center in Huntsville, AL has the agency lead to develop space transportation technologies. Within ASTP, under the Spaceliner100 Investment Area, third generation technologies are being pursued in the areas of propulsion, airframes, integrated vehicle health management (IVHM), launch systems, and operations and range. The ASTP program will mature these technologies through ground system testing. Flight testing where required, will be advocated on a case by case basis.

Cytological and ultrastructural studies on root tissues

NASA Technical Reports Server (NTRS)

Slocum, R. D.; Gaynor, J. J.; Galston, A. W.

1984-01-01

The anatomy and fine structure of roots from oat and mung bean seedlings, grown under microgravity conditions for 8 days aboard the Space Shuttle, was examined and compared to that of roots from ground control plants grown under similar conditions. Roots from both sets of oat seedlings exhibited characteristic monocotyledonous tissue organization and normal ultrastructural features, except for cortex cell mitochondria, which exhibited a 'swollen' morphology. Various stages of cell division were observed in the meristematic tissues of oat roots. Ground control and flight-grown mung bean roots also showed normal tissue organization, but root cap cells in the flight-grown roots were collapsed and degraded in appearance, especially at the cap periphery. At the ultrastructural level, these cells exhibited a loss of organelle integrity and a highly-condensed cytoplasm. This latter observation perhaps suggests a differing tissue sensitivity for the two species to growth conditions employed in space flight. The basis for abnormal root cap cell development is not understood, but the loss of these putative gravity-sensing cells holds potential significance for long term plant growth orientation during space flight.

CO2 Removal and Atmosphere Revitalization Systems for Next Generation Space Flight

NASA Technical Reports Server (NTRS)

Luna, Bernadette; Mulloth, Lila M.; Varghese, Mini M.; Hogan, John Andrew

2010-01-01

Removal of metabolic CO2 from breathing air is a vital process for life support in all crewed space missions. A CO2 removal processor called the Low Power CO2 Removal (LPCOR) system is being developed in the Bioengineering Branch at NASA Ames Research Center. LPCOR utilizes advanced adsorption and membrane gas separation processes to achieve substantial power and mass reduction when compared to the state-of-the-art carbon dioxide removal assembly (CORA) of the US segment of the International Space Station (ISS). LPCOR is an attractive alternative for use in commercial spacecraft for short-duration missions and can easily be adapted for closed-loop life support applications. NASA envisions a next-generation closed-loop atmosphere revitalization system that integrates advanced CO2 removal, O2 recovery, and trace contaminant control processes to improve overall system efficiency. LPCOR will serve as the front end to such a system. LPCOR is a reliable air revitalization technology that can serve both the near-term and long-term human space flight needs of NASA and its commercial partners.

Flight- and Ground-Based Materials Science Programs at NASA

NASA Technical Reports Server (NTRS)

Gillies, Donald C.

1999-01-01

The Microgravity Research Division of NASA funds research programs in all branches of materials science including ceramics and glasses. A NASA Research Announcement (NRA)is currently planned with proposals due in March 1999. Proposals are accepted for both flight- definition and ground- based research projects with a main criterion being a strong justification for microgravity. A review of the program in its entirety will be given, with special emphasis on microgravity related ceramics research. The topics of current interest in the NRA will be discussed in terms of International Space Station research and NASA's Human Exploration and Development of Space (HEDS) initiative.

Vitamin D endocrine system after short-term space flight

NASA Technical Reports Server (NTRS)

Rhoten, William B. (Principal Investigator); Sergeev, Igor N. (Principal Investigator)

1996-01-01

The exposure of the body to microgravity during space flight causes a series of well-documented changes in Ca(2+) metabolism, yet the cellular/molecular mechanisms leading to these changes are poorly understood. There is some evidence for microgravity-induced alterations in the vitamin D endocrine system, which is known to be primarily involved in the regulation of Ca(2+) metabolism. Vitamin D-dependent Ca(2+) binding proteins, or calbindins, are believed to have a significant role in maintaining cellular Ca(2+) homeostasis. We used immunocytochemical, biochemical and molecular approaches to analyze the expression of calbindin-D(sub 28k) and calbindin-D(sub 9k) in kidneys and intestines of rats flown for 9 days aboard the Spacelab 3 mission. The effects of microgravity on calbindins in rats in space vs. 'grounded' animals (synchronous Animal Enclosure Module controls and tail suspension controls) were compared. Exposure to microgravity resulted in a significant decrease in calbindin-D(sub 28k) content in kidneys and calbindin-D(sub 9k) in the intestine of flight and suspended animals, as measured by enzyme-linked immunosorbent assay (ELISA). Immunocytochemistry (ICC) in combination with quantitative computer image analysis was used to measure in situ the expression of calbindins in kidneys and intestine, and insulin in pancreas. There was a large decrease in the distal tubular cell-associated calbindin-D(sub 28k) and absorptive cell-associated calbindin-D(sub 9k) immunoreactivity in the space and suspension kidneys and intestine, as compared with matched ground controls. No consistent differences in pancreatic insulin immunoreactivity between space, suspension and ground controls was observed. There were significant correlations between results by quantitative ICC and ELISA. Western blot analysis showed no consistent changes in the low levels of intestinal and renal vitamin D receptors. These findings suggest that a decreased expression of calbindins after a short-term exposure to microgravity and modelled weightlessness, may affect cellular Ca(2+) homeostasis and contribute to Ca(2+) and bone metabolism disorders induced by space flight.

Decline in Aerobic Fitness After Long-Term Stays on the International Space Station

NASA Technical Reports Server (NTRS)

Lynn, Peggy A.; Minard, Charles; Moore, Alan; Babiak-Vazquez, Adriana

2010-01-01

U.S. and non-Russian International Partner astronauts who participate in long-term International Space Station (ISS) expeditions perform submaximal cycle exercise tests before, during, and after space flight. The heart rate (HR) and oxygen uptake (VO2) responses to exercise are used to estimate peak VO2 (EVO2pk). Purpose: To determine if the following factors are associated with the preflight-to-post flight change in EVO2pk: gender, age, body weight (BW), number of aerobic exercise sessions/wk- during flight, length of flight, EVO2pk measured before and late during the flight, ISS Expedition number and time between landing and the first post flight test. Methods: Records of 37 ISS astronauts (30 male, BW=81.6 plus or minus 8.6 kg; 7 female BW=66.1 plus or minus 4.9 kg [mean plus or minus SD]), age 46 plus or minus 4 years, were retrospectively examined. Peak HR and VO2 were measured approximately 9 months before flight to establish the test protocol. The submaximal cycle test consisted of three 5-minute stages designed to elicit 25, 50, and 75% of VO2pk. EVO2pk was calculated using linear least-squares extrapolation of average HR and VO2 during the last minute of each stage to predict VO2 at maximal HR. VO2 was not measured during flight and was assumed to not be different from preflight. Testing was performed 45 days before launch, late during flight, and during the week after landing. A random-intercept multivariate model was used to determine which characteristics significantly contributed to post flight EVO2pk. Results: In-flight aerobic exercise averaged 5.4 plus or minus 1.2 sessions/wk. ISS flight duration averaged 163 plus or minus 39 d. Mean EVO2pk values were 3.41 plus or minus 0.64 L (raised dot) per minute before flight, 3.09 plus or minus 0.57 L (raised dot) per minute late in flight, and 3.02 plus or minus 0.65 L (raised dot) per minute after flight. Late- and after-flight values were lower (p less than 0.05) than preflight values and did not differ from each other. Time between landing and post flight testing was 4.5 plus or minus 1.6 days. The only factor significantly associated with the post flight EVO2pk value was the late-flight EVO2pk score. Conclusion: Testing performed late during a mission provides a prediction of EVO2pk after landing. This approach may be implemented during longer missions.

An overview of European space transportation systems

NASA Technical Reports Server (NTRS)

Lo, R. E.

1985-01-01

With the completion of the launch rocket series Ariane 1 to 4, Europe will have reached the same capacity to transport commercial payloads as the USA has with the Space Shuttle and the kick stages which are presently operative. The near term development of these capacities would require Europe to develop a larger launch rocket, Araine 5. Further motivations for this rocket are access to manned spaceflight, the development of an European space station, and the demand for shuttle technology. Shuttle technology is the subject of research being done in France on the winged re-entry vehicle Hermes. Operation of the European space station Columbus will require development of an interorbital transport system to facilitate traffic between the various segments of the space station. All European space transportation systems will have to match their quality to that of the other countries involve in space flight. All areas of development are marked not only by possible cooperation but also by increased competition because of increasing commercialization of space flight.

NASA Human Research Program: Behavioral Health and Performance Program Element

NASA Technical Reports Server (NTRS)

Leveton, Lauren B.

2009-01-01

This viewgraph presentation reviews the performance errors associated with sleep loss, fatigue and psychomotor factors during manned space flight. Short and long term behavioral health factors are also addressed

Clothing and personal hygiene

NASA Technical Reports Server (NTRS)

Finogenov, A. M.; Azhayev, A. N.; Kaliberdin, G. V.

1975-01-01

The biomedical maintenance of astronauts is discussed in terms of personal hygiene. Principal characteristics and general requirements are described which must be followed in perfecting a system of hygienic practices and in devising means to maintain personal hygiene, flight clothing, underwear, bedding, and medical-domestic equipment for manned space flights of varying durations. Factors discussed include: disposable clothing, thermal protection, oral hygiene, cleansing of the skin, and grooming of the hair.

Assessment of Technologies for the Space Shuttle External Tank Thermal Protection System and Recommendations for Technology Improvement. Part 2; Structural Analysis Technologies and Modeling Practices

NASA Technical Reports Server (NTRS)

Knight, Norman F., Jr.; Nemeth, Michael P.; Hilburger, Mark W.

2004-01-01

A technology review and assessment of modeling and analysis efforts underway in support of a safe return to flight of the thermal protection system (TPS) for the Space Shuttle external tank (ET) are summarized. This review and assessment effort focuses on the structural modeling and analysis practices employed for ET TPS foam design and analysis and on identifying analysis capabilities needed in the short-term and long-term. The current understanding of the relationship between complex flight environments and ET TPS foam failure modes are reviewed as they relate to modeling and analysis. A literature review on modeling and analysis of TPS foam material systems is also presented. Finally, a review of modeling and analysis tools employed in the Space Shuttle Program is presented for the ET TPS acreage and close-out foam regions. This review includes existing simplified engineering analysis tools are well as finite element analysis procedures.

Results of the SOLCON FREESTAR Total Solar Irradiance measurements

NASA Astrophysics Data System (ADS)

Dewitte, S.; Joukoff, A.; Crommelynck, D.

2003-04-01

The measurement of the Total Solar Irradiance from space is ongoing since 1978. A long term series requires the combination of the time limited measurements of individual measurements. The accuracy of the long term series is limited by the absolute accuracy of the instruments, and by their ageing in space, due to exposure to UV radiation. As a reference for the combination of the different instruments, we use the measurements of the SOLar CONstant (SOLCON) instrument, which is flown regularly on the space shuttle. In this paper we will present the results of the most recent SOLCON flight, which is the Fast Reaction Experiments Enabling Science, Technology, Applications and Research (FREESTAR) flight foreseen from 16 Jan. 2003 to 1 Feb. 2003. The anticipated results are: 1) comparison of SOLCON with the new instruments Active Cavity Radiometer Irradiance Monitor (ACRIM) III, and 2) the Total Irradiance Monitor (TIM) on the Solar Radiation and Climate Experiment (SORCE) satellite, 3) verification of the ageing of the Variability of IRradiance and Gravity Oscillations (VIRGO) radiometers.

14 CFR 1214.1705 - Selection of space flight participants.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Selection of space flight participants. 1214.1705 Section 1214.1705 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Space Flight Participants § 1214.1705 Selection of space flight participants. (a) The agency will...

14 CFR 1214.1705 - Selection of space flight participants.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Selection of space flight participants. 1214.1705 Section 1214.1705 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Space Flight Participants § 1214.1705 Selection of space flight participants. (a) The agency will...

Logistics: An integral part of cost efficient space operations

NASA Technical Reports Server (NTRS)

Montgomery, Ann D.

1996-01-01

The logistics of space programs and its history within NASA are discussed, with emphasis on manned space flight and the Space Shuttle program. The lessons learned and the experience gained during these programs are reported on. Key elements of logistics are highlighted, and the problems and issues that can be expected to arise in relation to the support of long-term space operations and future space programs, are discussed. Such missions include the International Space Station program and the reusable launch vehicle. Possible solutions to the problems identified are outlined.

Latent Viruses: A Space Travel Hazard??

NASA Technical Reports Server (NTRS)

Ling, P. D.; Peng, R. S.; Pierson, D.; Lednicky, J.; Butel, J. S.

1999-01-01

A major issue associated with long-duration space flight is the possibility of infectious disease causing an unacceptable medical risk to crew members. Our proposal is designed to gain information that addresses several issues outlined in the Immunology/Infectious disease critical path. The major hypothesis addressed is that space flight causes alterations in the immune system that may allow latent viruses which are endogenous in the human population to reactivate and shed to higher levels than normal which can affect the health of crew members during a long term space-flight mission. We will initially focus our studies on the human herpesviruses and human polyomaviruses which are important pathogens known to establish latent infections in the human population. Both primary infection and reactivation from latent infection with this group of viruses can cause a variety of illnesses that result in morbidity and occasionally mortality of infected individuals. Effective vaccines exist for only one of the eight known human herpesviruses and the vaccine itself can still reactivate from latent infection. Available antivirals are of limited use and are effective against only a few of the human herpesviruses. Although most individuals display little if any clinical consequences from latent infection, events which alter immune function such as immunosuppressive therapy following solid organ transplantation are known to increase the risk of developing complications as a result of latent virus reactivation. This proposal will measure both the frequency and magnitude of viral shedding and genome loads in the blood from humans participating in activities that serve as ground based models of space flight conditions. Our initial goal is to develop sensitive quantitative competitive PCR- based assays (QC-PCR) to detect the herpesvirus Epstein-Barr virus (EBV), and the polyomaviruses SV40, BKV, and JCV. Using these assays we will establish baseline patterns of viral genome load in the blood and viral shedding from normal volunteers in a longitudinal study over I year in length. As a comparison, we will measure patterns of viral genome loads and shedding from individuals who are severely immunosuppressed, in whom herpesvirus reactivation or primary infection with a herpesvirus is known to cause complications. In addition, we will proceed to testing ground based analogs in collaboration with Dr. Duane Pierson (Lyndon B. Johnson Space Center). This will include measuring samples obtained from individuals living and working in the extreme environment of Antarctica. We expect to detect viral shedding or reactivation from most of the test groups, although the magnitude of shedding or reactivation cannot be predicted. The data accumulated from studies in this proposal should allow us to evaluate whether events that simulate certain aspects of space flight reactivate viral infections severe enough in nature that they may compromise the success of long-term space flight missions. These studies will also provide a foundation to monitor viral reactivation and shedding from crew members participating in actual space flight missions. We will present data showing the establishment of our QC-PCR assay for detection of EBV.

Bone Markers, Calcium Metabolism, and Calcium Kinetics During Extended-Duration Space Flight on the Mir Space Station

NASA Technical Reports Server (NTRS)

Smith, Scott M.; Wastney, Meryl E.; O'Brien, Kimberly O.; Morukov, Boris V.; Larina, Irina M.; Abrams, Steven A.; Davis-Street, Janis E.; Oganov, Victor; Shackelford, Linda C.

2005-01-01

Bone loss is a current limitation for long-term space exploration. Bone markers, calcitropic hormones, and calcium kinetics of crew members on space missions of 4-6 months were evaluated. Spaceflight-induced bone loss was associated with increased bone resorption and decreased calcium absorption. INTRODUCTION: Bone loss is a significant concern for the health of astronauts on long-duration missions. Defining the time course and mechanism of these changes will aid in developing means to counteract these losses during space flight and will have relevance for other clinical situations that impair weight-bearing activity. MATERIALS AND METHODS: We report here results from two studies conducted during the Shuttle-Mir Science Program. Study 1 was an evaluation of bone and calcium biochemical markers of 13 subjects before and after long-duration (4-6 months) space missions. In study 2, stable calcium isotopes were used to evaluate calcium metabolism in six subjects before, during, and after flight. Relationships between measures of bone turnover, biochemical markers, and calcium kinetics were examined. RESULTS: Pre- and postflight study results confirmed that, after landing, bone resorption was increased, as indicated by increases in urinary calcium (p < 0.05) and collagen cross-links (N-telopeptide, pyridinoline, and deoxypyridinoline were all increased >55% above preflight levels, p < 0.001). Parathyroid hormone and vitamin D metabolites were unchanged at landing. Biochemical markers of bone formation were unchanged at landing, but 2-3 weeks later, both bone-specific alkaline phosphatase and osteocalcin were significantly (p < 0.01) increased above preflight levels. In studies conducted during flight, bone resorption markers were also significantly higher than before flight. The calcium kinetic data also validated that bone resorption was increased during flight compared with preflight values (668 +/- 130 versus 427 +/- 153 mg/day; p < 0.001) and clearly documented that true intestinal calcium absorption was significantly lower during flight compared with preflight values (233 +/- 87 versus 460 +/- 47 mg/day; p < 0.01). Weightlessness had a detrimental effect on the balance in bone turnover such that the daily difference in calcium retention during flight compared with preflight values approached 300 mg/day (-234 +/- 102 versus 63 +/- 75 mg/day; p < 0.01). CONCLUSIONS: These bone marker and calcium kinetic studies indicated that the bone loss that occurs during space flight is a consequence of increased bone resorption and decreased intestinal calcium absorption.

Radiation-Related Risk Analysis for Atmospheric Flight Civil Aviation Flight Personnel

NASA Technical Reports Server (NTRS)

DeAngelis, G.; Wilson, J. W.

2003-01-01

Human data on low dose rate radiation exposure and consequent effects are not readily available, and this fact generates groundtruth concerns for all risk assessment techniques for possible health effects induced by the space radiation environment, especially for long term missions like those foreseen now and in the near future. A large amount of such data may be obtained through civil aviation flight personnel cohorts, in the form of epidemiological studies on delayed health effects induced by the cosmic-ray generated atmospheric radiation environment, a high- LET low dose and low dose rate ionizing radiation with its typical neutron component, to which flight personnel are exposed all throughout their work activity. In the perspective of worldwide studies on radiation exposure of the civil aviation flight personnel, all the available results from previous studies on flight personnel radiation exposure have been examined in various ways (i.e. literature review, meta-analysis) to evaluate possible significant associations between atmospheric ionizing radiation environment and health risks, and to assess directions for future investigations. The physical characteristics of the atmospheric ionizing radiation environment make the results obtained for atmospheric flight personnel relevant for space exploration.

Rocket exhaust effluent modeling for tropospheric air quality and environmental assessments

NASA Technical Reports Server (NTRS)

Stephens, J. B.; Stewart, R. B.

1977-01-01

The various techniques for diffusion predictions to support air quality predictions and environmental assessments for aerospace applications are discussed in terms of limitations imposed by atmospheric data. This affords an introduction to the rationale behind the selection of the National Aeronautics and Space Administration (NASA)/Marshall Space Flight Center (MSFC) Rocket Exhaust Effluent Diffusion (REED) program. The models utilized in the NASA/MSFC REED program are explained. This program is then evaluated in terms of some results from a joint MSFC/Langley Research Center/Kennedy Space Center Titan Exhaust Effluent Prediction and Monitoring Program.

Space flight requirements for fiber optic components: qualification testing and lessons learned

NASA Astrophysics Data System (ADS)

Ott, Melanie N.; Jin, Xiaodan Linda; Chuska, Richard; Friedberg, Patricia; Malenab, Mary; Matuszeski, Adam

2006-04-01

"Qualification" of fiber optic components holds a very different meaning than it did ten years ago. In the past, qualification meant extensive prolonged testing and screening that led to a programmatic method of reliability assurance. For space flight programs today, the combination of using higher performance commercial technology, with shorter development schedules and tighter mission budgets makes long term testing and reliability characterization unfeasible. In many cases space flight missions will be using technology within years of its development and an example of this is fiber laser technology. Although the technology itself is not a new product the components that comprise a fiber laser system change frequently as processes and packaging changes occur. Once a process or the materials for manufacturing a component change, even the data that existed on its predecessor can no longer provide assurance on the newer version. In order to assure reliability during a space flight mission, the component engineer must understand the requirements of the space flight environment as well as the physics of failure of the components themselves. This can be incorporated into an efficient and effective testing plan that "qualifies" a component to specific criteria defined by the program given the mission requirements and the component limitations. This requires interaction at the very initial stages of design between the system design engineer, mechanical engineer, subsystem engineer and the component hardware engineer. Although this is the desired interaction what typically occurs is that the subsystem engineer asks the components or development engineers to meet difficult requirements without knowledge of the current industry situation or the lack of qualification data. This is then passed on to the vendor who can provide little help with such a harsh set of requirements due to high cost of testing for space flight environments. This presentation is designed to guide the engineers of design, development and components, and vendors of commercial components with how to make an efficient and effective qualification test plan with some basic generic information about many space flight requirements. Issues related to the physics of failure, acceptance criteria and lessons learned will also be discussed to assist with understanding how to approach a space flight mission in an ever changing commercial photonics industry.

Space Flight Requirements for Fiber Optic Components; Qualification Testing and Lessons Learned

NASA Technical Reports Server (NTRS)

Ott, Melanie N.; Jin, Xiaodan Linda; Chuska, Richard; Friedberg, Patricia; Malenab, Mary; Matuszeski, Adam

2007-01-01

"Qualification" of fiber optic components holds a very different meaning than it did ten years ago. In the past, qualification meant extensive prolonged testing and screening that led to a programmatic method of reliability assurance. For space flight programs today, the combination of using higher performance commercial technology, with shorter development schedules and tighter mission budgets makes long term testing and reliability characterization unfeasible. In many cases space flight missions will be using technology within years of its development and an example of this is fiber laser technology. Although the technology itself is not a new product the components that comprise a fiber laser system change frequently as processes and packaging changes occur. Once a process or the materials for manufacturing a component change, even the data that existed on its predecessor can no longer provide assurance on the newer version. In order to assure reliability during a space flight mission, the component engineer must understand the requirements of the space flight environment as well as the physics of failure of the components themselves. This can be incorporated into an efficient and effective testing plan that "qualifies" a component to specific criteria defined by the program given the mission requirements and the component limitations. This requires interaction at the very initial stages of design between the system design engineer, mechanical engineer, subsystem engineer and the component hardware engineer. Although this is the desired interaction what typically occurs is that the subsystem engineer asks the components or development engineers to meet difficult requirements without knowledge of the current industry situation or the lack of qualification data. This is then passed on to the vendor who can provide little help with such a harsh set of requirements due to high cost of testing for space flight environments. This presentation is designed to guide the engineers of design, development and components, and vendors of commercial components with how to make an efficient and effective qualification test plan with some basic generic information about many space flight requirements. Issues related to the physics of failure, acceptance criteria and lessons learned will also be discussed to assist with understanding how to approach a space flight mission in an ever changing commercial photonics industry.

Space Medicine

NASA Technical Reports Server (NTRS)

Pool, Sam L.

2000-01-01

The National Academy of Sciences Committee on Space Biology and Medicine points out that space medicine is unique among space sciences, because in addition to addressing questions of fundamental scientific interest, it must address clinical or human health and safety issues as well. Efforts to identify how microgravity affects human physiology began in earnest by the United States in 1960 with the establishment of the National Aeronautics and Space Administration (NASA's) Life Sciences program. Before the first human space missions, prediction about the physiological effects of microgravity in space ranged from extremely severe to none at all. The understanding that has developed from our experiences in space to date allows us to be guardedly optimistic about the ultimate accommodations of humans to space flight. Only by our travels into the microgravity environment of space have we begun to unravel the mysteries associated with gravity's role in shaping human physiology. Space medicine is still at its very earliest stages. Development of this field has been slow for several reasons, including the limited number of space flights, the small number of research subjects, and the competition within the life sciences community and other disciplines for flight opportunities. The physiological changes incurred during space flight may have a dramatic effect on the course of an injury or illness. These physiological changes present an exciting challenge for the field of space medicine: how to best preserve human health and safety while simultaneously deciphering the effects of microgravity on human performance. As the United States considers the future of humans in long-term space travel, it is essential that the many mysteries as to how microgravity affects human systems be addressed with vigor. Based on the current state of our knowledge, the justification is excellent indeed compelling- for NASA to develop a sophisticated capability in space medicine. Teams of physicians and scientists should be actively engaged in fundamental and applied research designed to ensure that it is safe for humans to routinely and repeatedly stay and work in the microgravity environment of space.

14 CFR § 1214.1705 - Selection of space flight participants.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Selection of space flight participants. § 1214.1705 Section § 1214.1705 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Space Flight Participants § 1214.1705 Selection of space flight participants. (a) The...

Acute and Chronic Exposure to CO2 in Space Flight

NASA Technical Reports Server (NTRS)

Alexander, D.; Wu, J.; Barr, Y. R.; Watkins, S. D.

2010-01-01

Spacecraft and space stations, similar to other habitable confined spaces such as submarines, need to provide a breathable atmosphere for their inhabitants. The inevitable production of CO2 during respiration necessitates life support systems that "scrub" the atmosphere and lower CO2 levels. Due to operational limitations associated with space flight (limited mass, volume, power, and consumables) CO2 is not scrubbed down to its terrestrial equivalent of 0.03% CO2 (ppCO2 of 0.23 mmHg), but is kept below 0.7% (ppCO2 of 5.3 mmHg), a level established in NASA s 180-day mission Spacecraft Maximum Allowable Concentration (SMAC) to be safe and unlikely to cause symptoms. Reports of space flight crewmembers becoming symptomatic with headaches, fatigue, and malaise at levels below those known to cause such symptoms terrestrially has prompted studies measuring the levels of CO2 on both the space shuttle and the space station. Data from cabin atmosphere sampling were collected on space shuttle missions STS-113, STS-122, STS-123, and International Space Station Expeditions 12-15 and 17, and the measured CO2 levels were then correlated to symptoms reported by the crew. The results indicate that a correlation exists between CO2 levels and symptomatology, however causality cannot be established at this time. While the short-term effects of elevated CO2 exposure are well known terrestrially, less is known regarding potential long-term effects of prolonged exposure to a CO2-rich environment or how the physiological changes caused by microgravity may interact with such exposures. Other challenges include limitations in the CO2 monitors used, lack of convection in the microgravity environment, and formation of localized CO2 pockets. As it is unclear if the unique environment of space increases sensitivity to CO2 or if other confounding factors are present, further research is planned to elucidate these points. At the same time, efforts are underway to update the SMAC to a lower level

Space shuttle/food system study. Volume 2, appendix E: Alternate flight systems analysis

NASA Technical Reports Server (NTRS)

1974-01-01

The functional requirements of stowage, preparation, serving, consumption, and cleanup were applied to each of the five food mixes selected for study in terms of the overall design of the space shuttle food system. The analysis led to a definition of performance requirements for each food mix, along with a definition of equipment to meet those requirements. Weight and volume data for all five systems, in terms of food and packaging, support equipment, and galley installation penalties, are presented.

Central and peripheral regulation of feeding and nutrition by the mammalian circadian clock: implications for nutrition during manned space flight

NASA Technical Reports Server (NTRS)

Cassone, Vincent M.; Stephan, Friedrich K.

2002-01-01

Circadian clocks have evolved to predict and coordinate physiologic processes with the rhythmic environment on Earth. Space studies in non-human primates and humans have suggested that this clock persists in its rhythmicity in space but that its function is altered significantly in long-term space flight. Under normal circumstances, the clock is synchronized by the light-dark cycle via the retinohypothalamic tract and the suprachiasmatic nucleus. It is also entrained by restricted feeding regimes via a suprachiasmatic nucleus-independent circadian oscillator. The site of this suboscillator (or oscillators) is not known, but new evidence has suggested that peripheral tissues in the liver and viscera may express circadian clock function when forced to do so by restricted feeding schedules or other homeostatic disruptions. New research on the role of the circadian clock in the control of feeding on Earth and in space is warranted.

Thermal control surfaces experiment flight system performance

NASA Technical Reports Server (NTRS)

Wilkes, Donald R.; Hummer, Leigh L.; Zwiener, James M.

1991-01-01

The Thermal Control Surfaces Experiment (TCSE) is the most complex system, other than the LDEF, retrieved after long term space exposure. The TCSE is a microcosm of complex electro-optical payloads being developed and flow by NASA and the DoD including SDI. The objective of TCSE was to determine the effects of the near-Earth orbital environment and the LDEF induced environment on spacecraft thermal control surfaces. The TCSE was a comprehensive experiment that combined in-space measurements with extensive post flight analyses of thermal control surfaces to determine the effects of exposure to the low earth orbit space environment. The TCSE was the first space experiment to measure the optical properties of thermal control surfaces the way they are routinely measured in a lab. The performance of the TCSE confirms that low cost, complex experiment packages can be developed that perform well in space.

Effect of lead-aircraft ground-speed on self-spacing performance using a cockpit display of traffic information

NASA Technical Reports Server (NTRS)

Kelly, J. R.

1983-01-01

A simulator investigation was conducted to determine the effect of the lead-aircraft ground-speed quantization level on self-spacing performance using a Cockpit Display of Traffic Information (CDTI). The study utilized a simulator employing cathode-ray tubes for the primary flight and navigation displays and highly augmented flight control modes. The pilot's task was to follow, and self-space on, a lead aircraft which was performing an idle-thrust profile descent to an instrument landing system (ILS) approach and landing. The spacing requirement was specified in terms of both a minimum distance and a time interval. The results indicate that the ground-speed quantization level, lead-aircraft scenario, and pilot technique had a significant effect on self-spacing performance. However, the ground-speed quantization level only had a significant effect on the performance when the lead aircraft flew a fast final approach.

Study of efficient video compression algorithms for space shuttle applications

NASA Technical Reports Server (NTRS)

Poo, Z.

1975-01-01

Results are presented of a study on video data compression techniques applicable to space flight communication. This study is directed towards monochrome (black and white) picture communication with special emphasis on feasibility of hardware implementation. The primary factors for such a communication system in space flight application are: picture quality, system reliability, power comsumption, and hardware weight. In terms of hardware implementation, these are directly related to hardware complexity, effectiveness of the hardware algorithm, immunity of the source code to channel noise, and data transmission rate (or transmission bandwidth). A system is recommended, and its hardware requirement summarized. Simulations of the study were performed on the improved LIM video controller which is computer-controlled by the META-4 CPU.

Space transportation system payload interface verification

NASA Technical Reports Server (NTRS)

Everline, R. T.

1977-01-01

The paper considers STS payload-interface verification requirements and the capability provided by STS to support verification. The intent is to standardize as many interfaces as possible, not only through the design, development, test and evaluation (DDT and E) phase of the major payload carriers but also into the operational phase. The verification process is discussed in terms of its various elements, such as the Space Shuttle DDT and E (including the orbital flight test program) and the major payload carriers DDT and E (including the first flights). Five tools derived from the Space Shuttle DDT and E are available to support the verification process: mathematical (structural and thermal) models, the Shuttle Avionics Integration Laboratory, the Shuttle Manipulator Development Facility, and interface-verification equipment (cargo-integration test equipment).

Countermeasures for Maintenance of Cardiovascular and Muscle Function in Space Flight

NASA Technical Reports Server (NTRS)

1997-01-01

In this session, Session FA2, the discussion focuses on the following topics: Effects of Repeated Long Duration +2Gz Load on Man's Cardiovascular Function; Certain Approaches to the Development of On-Board Automated Training System; Cardiac, Arterial, and Venous Adaptation to Og during 6 Month MIR-Spaceflights with and without "Thigh Cuffs" (93-95); Space Cycle(TM) Induced Physiologic Responses; Muscular Deconditioning During Long-term Spaceflight Exercise Recommendations to Optimize Crew Performance; Structure And Function of Knee Extensors After Long-Duration Spaceflight in Man, Effects of Countermeasure Exercise Training; Force and power characteristics of an exercise ergometer designed for use in space; and The simulating of overgravity conditions for astronauts' motor apparatus at the conditions of the training for orbital flights.

National Space Biomedical Research Institute Annual Report

NASA Technical Reports Server (NTRS)

2000-01-01

This report summarizes the activities of the National Space Biomedical Research Institute (NSBRI) during FY 2000. The NSBRI is responsible for the development of countermeasures against the deleterious effects of long-duration space flight and performs fundamental and applied space biomedical research directed towards this specific goal. Its mission is to lead a world-class, national effort in integrated, critical path space biomedical research that supports NASA's Human Exploration and Development of Space (HEDS) Strategic Plan by focusing on the enabling of long-term human presence in, development of, and exploration of space. This is accomplished by: designing, testing and validating effective countermeasures to address the biological and environmental impediments to long-term human space flight; defining the molecular, cellular, organ-level, integrated responses and mechanistic relationships that ultimately determine these impediments, where such activity fosters the development of novel countermeasures; establishing biomedical support technologies to maximize human performance in space, reduce biomedical hazards to an acceptable level, and deliver quality medical care; transferring and disseminating the biomedical advances in knowledge and technology acquired through living and working in space to the general benefit of mankind, including the treatment of patients suffering from gravity- and radiation-related conditions on Earth; and ensuring open involvement of the scientific community, industry and the public at large in the Institute's activities and fostering a robust collaboration with NASA, particularly through NASA's Lyndon B. Johnson Space Center. Attachment:Appendices (A,B,C,D,E,F,G,H,I,J,K,L,M,N,O, and P.).

Surviving space flight: case study on MELiSSA's CIII nitrifying compartment

NASA Astrophysics Data System (ADS)

Ilgrande, Chiara; Lasseur, Christophe; Mastroleo, Felice; Paille, Christel; Leys, Natalie; Morozova, Julia; Ilyin, Vyacheslav; Clauwaert, Peter; Christiaens, Marlies E. R.; Lindeboom, Ralph E. F.; Vlaeminck, Siegfried; Prat, Delphine; Arroyo, Jose M. C.; Conincx, Ilse; Van Hoey, Olivier; Roume, Hugo; Udert, Kai; Sas, Benedikt

2016-07-01

Space synthetic biology offers key opportunities for long-term space missions. Planets mining, terraformation, space medicine and Life Support technologies would all benefit from an integrative biological approach. However, space is a harsh environment for life: microgravity, temperature, UV and cosmic radiation can affect the health and functionality of microorganisms and plants, possibly preventing the optimal performance of the systems. The European Space Agency's Life Support System (MELiSSA) has been developed as a model for future long term Space missions and Space habitation. MELiSSA is a 5 compartment artificial ecosystem with microorganisms and higher, that aims at completely recycling gas, liquid and solid waste. In this study, the survival and functional activity after Lower Earth Orbit conditions of microbial nitrogen conversions, relevant for MELiSSA's CIII compartment, was tested. Synthetic communities containing Nitrosomonas europeae, Nitrosomonas ureae, Nitrobacter winogradskyi, Nitrospira moscoviensis and Cupriavidus pinatubonensis were exposed to the Lower Earth Orbit conditions of the International Space Station (ISS) for 7 days. Nitrosomonas europeae, Nitrobacter winogradskyi, Cupriavidus pinatubonensis, and three mixed communities (a urine nitrification sludge, a sludge containing aerobic ammonia oxidizing bacteria and anammox bacteria (OLAND), and an aquaculture sludge containing ammonia oxidizing archaea) were exposed to Lower Earth Orbit conditions for 44 days. Survival after both space flights was demonstrated because nitritation, nitratation, denitrification and anammox activity could be restored at a rate comparable to ground storage conditions. Our results validate the potential survival feasibility and suggest future space applications for N-related microorganisms.

14 CFR 435.8 - Human space flight.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Human space flight. 435.8 Section 435.8 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Human space flight. An applicant for a license to conduct a reentry with flight crew or a space flight...

14 CFR 435.8 - Human space flight.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Human space flight. 435.8 Section 435.8 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Human space flight. An applicant for a license to conduct a reentry with flight crew or a space flight...

14 CFR 435.8 - Human space flight.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Human space flight. 435.8 Section 435.8 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Human space flight. An applicant for a license to conduct a reentry with flight crew or a space flight...

14 CFR 435.8 - Human space flight.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Human space flight. 435.8 Section 435.8 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Human space flight. An applicant for a license to conduct a reentry with flight crew or a space flight...

14 CFR 435.8 - Human space flight.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Human space flight. 435.8 Section 435.8 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... Human space flight. An applicant for a license to conduct a reentry with flight crew or a space flight...

Transition to space - A history of 'space plane' concepts at Langley Aeronautical Laboratory 1952-1957

NASA Technical Reports Server (NTRS)

Hansen, James R.

1987-01-01

The supersonic speeds of X-series aircraft and wind tunnel data in the early 1950s demonstrated that hypersonic flight was an achievable goal. A blunt-nosed vehicle was found to form a bow shock that deflected much of the heating an aircraft would otherwise experience at high speeds. It was felt that critical aspects of hypersonic flight, e.g., aerodynamic performance and heating, controllability, etc., could not be fully explored in wind tunnels. The X-15 project was initiated by NASA in 1954 to produce a vehicle capable of Mach 7 flight to altitudes that would permit short evaluations of human performance in microgravity. Design tradeoffs examined in the program are discussed, with emphasis on lifting bodies and winged vehicles with high L/D ratios. Political pressures created by the public triumph of the Sputnik in 1958 removed much of the impetus for development of a manned spaceplane, and long-term goals that eventually led to the Shuttle were delayed by a short-term program oriented toward ballistic manned capsules.

Development of a test and flight engineering oriented language, phase 3

NASA Technical Reports Server (NTRS)

Kamsler, W. F.; Case, C. W.; Kinney, E. L.; Gyure, J.

1970-01-01

Based on an analysis of previously developed test oriented languages and a study of test language requirements, a high order language was designed to enable test and flight engineers to checkout and operate the proposed space shuttle and other NASA vehicles and experiments. The language is called ALOFT (a language oriented to flight engineering and testing). The language is described, its terminology is compared to similar terms in other test languages, and its features and utilization are discussed. The appendix provides the specifications for ALOFT.

NASA philosophy concerning space stations as operations centers for construction and maintenance of large orbiting energy systems

NASA Technical Reports Server (NTRS)

Freitag, R. F.

1976-01-01

Future United States plans for manned space-flight activities are summarized, emphasizing the long-term goals of achieving permanent occupancy and limited self-sufficiency in space. NASA-sponsored studies of earth-orbiting Space Station concepts are reviewed along with lessons learned from the Skylab missions. Descriptions are presented of the Space Transportation System, the Space Construction Base, and the concept of space industrialization (the processing and manufacturing of goods in space). Future plans for communications satellites, solar-power satellites, terrestrial observations from space stations, and manned orbital-transfer vehicles are discussed.

Increase of larger-sized islets in C57/black mice during the long-term space flight.

NASA Astrophysics Data System (ADS)

Proshchina, Alexandra; Krivova, Yulia

Alteration of metabolism has been suggested as a major limiting factor to long-term space flight. Metabolic studies during simulated microgravity and true microgravity in flight have shown changes in blood glucose and in insulin and glucagon concentrations. It was suggested that endocrine pancreas undergoes subclinical diabetogenic changes such as alterations in insulin secretion, insulin sensitivity, glucose tolerance in microgravity conditions. In this study, we analyzed pancreata of the C57 black mice in order to estimate the effects of the long-term space flight. 5 mice, which were flown on the “Bion-M1” satellite for 30 days, were served for this study (flight group). Five animals were used as the vivarium ground control and five mice as the delayed synchronous ground control. The mice from synchronous control were put into container, similar to that one of the flight group for 30 days. Interestingly, the mean body weight of researched animals was higher in the flight group than in two control groups. Body weight in synchronous ground control group was higher than in vivarium control. From each mouse, the splenic part of the pancreas was removed and immediately fixed in 4% formaldehyde. Samples were embedded in paraffin, and 10 mcm serial sections were prepared. Double immunohistochemical staining with anti-insulin(Sigma,USA) and anti-glucagon (Thermo Fisher Scientific, USA) antibodies were performed. Signals were visualized using the MultiVision Polymer Detection System (Thermo Fisher Scientific, USA). Stained sections were photographed, using a 10 x objective and morphometrical parameters were examined. The size of each islet in ten non-overlapping observation fields in pancreatic sections of each mouse was measured using Image J software and analyzed. A software statistical package was used (Statistica 6.0, Statsoft Inc., Tusla, USA). A nonparametric tests (Kruskal -Wallis and Mann-Whitney tests) were used, because the islets number in the examined groups are of unequal size. The P-value was considered significant if less than 0.05. The islets in all three groups have a typical for murine pancreas architecture. The insulin-containing cells occupied the central position in pancreatic islets and the glucagon-containing cells were localized at the periphery. Histomorphometric analyses revealed significant increase of islets size in flight group compared with vivarium ground control. Moreover, the islets in group of the delayed synchronous ground control were significant larger then in group of vivarium control. No significant differences were found in islet size between flight and delayed synchronous ground control groups, but analyses indicated the increase of larger-sized islets in mice of flight group compared with synchronous control. Thus the mean islets size correlated with the body weight. The literature data indicates that similar changes are also observed in mice under conditions of an increased demand for insulin such as pregnancy, obesity, diabetes etc. According to the literature data, the researches of activity of pancreas have shown the increase of pancreatic hormones (insulin and C-peptide) in blood of astronauts in the early period after completion of space flights of various durations. In our study, the increase of islets size occurred not only in mice from flight group, but also in synchronous ground control. For this group, the live conditions imitated those of flight group without the factors of spaceflight such as microgravity. Therefore, we supposed that the hypokinesia play an important role in alteration of islets size. Thus, our data confirms the hypothesis of association microgravity and its experimental paradigms with manifestations similar to those of physical inactivity and diabetes.

Enhanced Polyhydroxybutyrate Production for Long-Term Spaceflight Applications

NASA Technical Reports Server (NTRS)

Putman, Ryan J.; Rahman, Asif; Miller, Charles D.; Hadi, Masood Z.

2015-01-01

Synthetic biology holds the promise of advancing long term space fight by the production of medicine, food, materials, and energy. One such application of synthetic biology is the production of biomaterials, specifically polyhydroxyalkanoates (PHAs), using purposed organisms such as Escherichia coli. PHAs are a group of biodegradable bioplastics that are produced by a wide variety of naturally occurring microorganisms, mainly as an energy storage intermediate. PHAs have similar melting point to polypropylene and a Youngs modulus close to polystyrene. Due to limited resources and cost of transportation, large-scale extraction of biologically produced products in situ is extremely cumbersome during space flight. To that end, we are developing a secretion systems for exporting PHA from the cell in order to reduce unit operations. PHAs granules deposited inside bacteria are typically associated with proteins bound to the granule surface. Phasin, a granule bound protein, was targeted for type I secretion by fusion with HlyA signal peptide for indirect secretion of PHAs. In order to validate our secretion strategy, a green fluorescent protein (GFP) was tagged to the PHA polymerase enzyme (phaC), this three part gene cassette consists of phaA and phaB and are required for PHA production. Producing PHAs in situ during space flight or planet colonization will enable mission success by providing a valuable source of biomaterials that can have many potential applications thereby reducing resupply requirements. Biologically produced PHAs can be used in additive manufacturing such as three dimensional (3D) printing to create products that can be made on demand during space flight. After exceeding their lifetime, the PHAs could be melted and recycled back to 3D print other products. We will discuss some of our long term goals of this approach.

Breast Cancer Research at NASA

NASA Technical Reports Server (NTRS)

1998-01-01

Isolation of human mammary epithelial cells (HMEC) from breast cancer susceptible tissue; A: Duct element recovered from breast tissue digest. B: Outgrowth of cells from duct element in upper right corner cultured in a standard dish; most cells spontaneousely die during early cell divisions, but a few will establish long-term growth. C: Isolate of long-term frowth HMEC from outgrowth of duct element; cells shown soon after isolation and in early full-cell contact growth in culture in a dish. D: same long-term growth HMEC, but after 3 weeks in late full-cell contact growth in a continuous culture in a dish. Note attempts to reform duct elements but this in two demensions in a dish rather than in three dimensions in tissue. NASA's Marshall Space Flight Center (MSFC) is sponsoring research with Bioreactors, rotating wall vessels designed to grow tissue samples in space, to understand how breast cancer works. This ground-based work studies the growth and assembly of human mammary epithelial cell (HMEC) from breast cancer susceptible tissue. Radiation can make the cells cancerous, thus allowing better comparisons of healthy vs. tunorous tissue. Credit: Dr. Robert Richmond, NASA/Marshall Space Flight Center (MSFC).

Effect of 90-day space flight (MDS-ISS) on immunological parameters in mice: lymphocyte distribution and function

NASA Astrophysics Data System (ADS)

Roberts, Arthur; Lhuillier, Andrew; Liu, Yi; Ruggiu, Alessandra; Shi, Yufang

Elucidation of the effects of space flight on the immune system of astronauts and other animal species is important for the survival and success of manned space flight, especially long-term missions. Space flight exposes astronauts to microgravity, galactic cosmic radiation (GCR), and various psycho-social stressors. Blood samples from astronauts returning from space flight have shown changes in the numbers and types of circulating leukocytes. Similarly, normal lym-phocyte homeostasis has been shown to be severely affected in mice using ground-based models of microgravity and GCR exposure, as demonstrated by profound effects on several immuno-logical parameters examined by other investigators and ourselves. In particular, lymphocyte numbers are significantly reduced and subpopulation distribution is altered in the spleen, thy-mus, and peripheral blood following hindlimb unloading (HU) in mice. Lymphocyte depletion was found to be mediated through corticosteroid-induced apoptosis, although the molecular mechanism of apoptosis induction is still under investigation. The proliferative capacity of TCR-stimulated lymphocytes was also inhibited after HU. We have similarly shown that mice exposed to high-energy 56Fe ion radiation have decreased lymphocyte numbers and perturba-tions in proportions of various subpopulations, including CD4+ and CD8+ T cells, and B cells in the spleen, and maturation stages of immature T cells in the thymus. To compare these ground-based results to the effects of actual space-flight, fresh spleen and thymus samples were recently obtained from normal and transgenic mice immediately after 90 d. space-flight in the MDS, and identically-housed ground control mice. Total leukocyte numbers in each organ were enumerated, and subpopulation distribution was examined by flow cytometric analysis of CD3, CD4, CD8, CD19, CD25, DX-5, and CD11b. Splenic T cells were stimulated with anti-CD3 and assessed for proliferation after 2-4 d., and production of several cytokines was examined using Luminex technology and quantitative PCR. These data are currently being collected and analyzed.

Development of a Novel Space Flight Plan to Monitor Female Mice Fertility Using Reduced Crew Time

NASA Technical Reports Server (NTRS)

Christenson, Lane; Hong, Xiaoman; Alwood, Joshua S.; Ronca, April E.; Tash, Joseph S.; Talyansky, Yuli

2017-01-01

Ovarian estrogen impacts the normal homeostatic and metabolic processes of all tissues and organ systems within the body: particularly, but not limited to canonical space-flight impacted systems: bone, muscle, immune, wound repair, and cardiovascular. Effects of space flight on the ovarian estrogen production are therefore critical to our understanding of all space flight experiments using female mice, the current paradigm being used on the International Space Station (ISS). Recently, we demonstrated that vaginal wall histology could be used to determine the stage of the estrous cycle in female mice at the time of sacrifice in space. Moreover, this robust technique was completed following two post-flight freezethaw procedures of the carcasses (RR1 experiment). Thus, this technique represents a viable mechanism to determine the estrous cycle status of the female at the time of sacrifice and can be completed in a manner that does not impact primary experimental objectives. We propose that vaginal wall histology become a standard procedure completed on all mice sacrificed in space and that the individual estrous status of each animal be shared with all investigators. While evidence of estrous cyclicity was present in long-term (33 day) RR1 mice, fertility of female mice exposed to weightlessness remains unknown. In preparation for an upcoming funded NASA flight investigating the effects of long duration spaceflight on female fertility, we have refined our experimental design to minimize crew flight time and to accommodate the duration of Dragon capsule berth. These refinements maintain all our proposed primary and secondary experimental objectives. Briefly, in order to evaluate fertility, we will super ovulate mice using standard procedures (PMSG hCG), followed by collection of reproductive tract after follicular stimulation alone (PMSG) or following ovulation (hCG). Ovarian folliculogenesis and ovulation rate will be determined in fixed tissues following return in order to determine fertility. Ovarian and uterine tissues will also be evaluated by hormonal and gene expression profiling using quantitative approaches (radioimmunoassays, western blots, digital droplet PCR). Comparisons will be made to contemporary vivarium and Rodent Research Hardware Transporter and Habitat housed animals maintained on earth. Supported by NNX15AB48G to JST.

Characterizing Space Environments with Long-Term Space Plasma Archive Resources

NASA Technical Reports Server (NTRS)

Minow, Joseph I.; Miller, J. Scott; Diekmann, Anne M.; Parker, Linda N.

2009-01-01

A significant scientific benefit of establishing and maintaining long-term space plasma data archives is the ready access the archives afford to resources required for characterizing spacecraft design environments. Space systems must be capable of operating in the mean environments driven by climatology as well as the extremes that occur during individual space weather events. Long- term time series are necessary to obtain quantitative information on environment variability and extremes that characterize the mean and worst case environments that may be encountered during a mission. In addition, analysis of large data sets are important to scientific studies of flux limiting processes that provide a basis for establishing upper limits to environment specifications used in radiation or charging analyses. We present applications using data from existing archives and highlight their contributions to space environment models developed at Marshall Space Flight Center including the Chandra Radiation Model, ionospheric plasma variability models, and plasma models of the L2 space environment.

Physics of Colloids in Space: Flight Hardware Operations on ISS

NASA Technical Reports Server (NTRS)

Doherty, Michael P.; Bailey, Arthur E.; Jankovsky, Amy L.; Lorik, Tibor

2002-01-01

The Physics of Colloids in Space (PCS) experiment was launched on Space Shuttle STS-100 in April 2001 and integrated into EXpedite the PRocess of Experiments to Space Station Rack 2 on the International Space Station (ISS). This microgravity fluid physics investigation is being conducted in the ISS U.S. Lab 'Destiny' Module over a period of approximately thirteen months during the ISS assembly period from flight 6A through flight 9A. PCS is gathering data on the basic physical properties of simple colloidal suspensions by studying the structures that form. A colloid is a micron or submicron particle, be it solid, liquid, or gas. A colloidal suspension consists of these fine particles suspended in another medium. Common colloidal suspensions include paints, milk, salad dressings, cosmetics, and aerosols. Though these products are routinely produced and used, we still have much to learn about their behavior as well as the underlying properties of colloids in general. The long-term goal of the PCS investigation is to learn how to steer the growth of colloidal structures to create new materials. This experiment is the first part of a two-stage investigation conceived by Professor David Weitz of Harvard University (the Principal Investigator) along with Professor Peter Pusey of the University of Edinburgh (the Co-Investigator). This paper describes the flight hardware, experiment operations, and initial science findings of the first fluid physics payload to be conducted on ISS: The Physics of Colloids in Space.

Results of studies on long-term exposition of dormant forms of various organisms in outer space environment

NASA Astrophysics Data System (ADS)

Novikova, Nataliya; Gusev, Oleg; Sugimoto, Manabu; Deshevaya, Elena; Levinskikh, Margarita; Sychev, Vladimir; Okuda, Takashi; Orlov, Oleg; Alekseev, Victor; Poddubko, Svetlana; Polikarpov, Nikolay

The planetary quarantine is one of the key problems of deep space exploration. Risks of the possible transfer of biological objects across interplanetary space should be necessarily assessed during space exploration. The risks associated with a possible transfer of biological objects and primarily microorganisms in interplanetary space is a priority for space studies We can assume, that on the exterior side of both unmanned and manned space stations there can be millions of microbial cells, many of which are in spore forms, the stability of which towards the unfavorable factors is extremely high. However, direct evidence to support this assumption, obtained only in recent years. “Biorisk” is an apparatus designed for conduction of space experiments focused on long-term exposition of latent stages of different forms of organism on the outer side of Russian Segment of International Space Station was developed and used in SSC RF - Institute for Biomedical Problems RAS. The purpose of this experiment is to determine the principle capability of preservation of life capacity in test-cultures of microorganisms during long-term exposure (comparable with the term of interplanetary flight) in space. The first experiment was performed using spores of bacteria (Bacillus) and fungi (Penicillium, Aspergillus and Cladosporium) housed in 3 boxes that were exposed to outer space for 7, 12 or 18 months. It was for the first time demonstrated that bacterial and fungal spores could survive an exposure to outer space during the time period comparable with the duration of a return mission to Mars. Moreover, the microbial strains proved viable and highly active. The second experiment was expanded by flying, in addition to the above spores, dormant forms of higher plants, insects, lower crustaceans and vertebrates. The 31-month experiment showed that, in spite of harsher than in the first study temperatures, some specimens remained viable and capable of further multiplication. In summary, our experiments provided evidence that not only bacterial and fungal spores but also dormant forms of organisms that reached higher levels of evolutionary development had the capability to survive a long-term exposure to outer space. This observation suggests that they can be transferred on outer walls of space platforms during interplanetary missions. Our findings are of scientific interest as well as of importance for the development of planetary quarantine concepts related to future space flight.

Humans in Space: Summarizing the Medico-Biological Results of the Space Shuttle Program

NASA Technical Reports Server (NTRS)

Risin, Diana; Stepaniak, P. C.; Grounds, D. J.

2011-01-01

As we celebrate the 50th anniversary of Gagarin's flight that opened the era of Humans in Space we also commemorate the 30th anniversary of the Space Shuttle Program (SSP) which was triumphantly completed by the flight of STS-135 on July 21, 2011. These were great milestones in the history of Human Space Exploration. Many important questions regarding the ability of humans to adapt and function in space were answered for the past 50 years and many lessons have been learned. Significant contribution to answering these questions was made by the SSP. To ensure the availability of the Shuttle Program experiences to the international space community NASA has made a decision to summarize the medico-biological results of the SSP in a fundamental edition that is scheduled to be completed by the end of 2011 beginning 2012. The goal of this edition is to define the normal responses of the major physiological systems to short-duration space flights and provide a comprehensive source of information for planning, ensuring successful operational activities and for management of potential medical problems that might arise during future long-term space missions. The book includes the following sections: 1. History of Shuttle Biomedical Research and Operations; 2. Medical Operations Overview Systems, Monitoring, and Care; 3. Biomedical Research Overview; 4. System-specific Adaptations/Responses, Issues, and Countermeasures; 5. Multisystem Issues and Countermeasures. In addition, selected operational documents will be presented in the appendices. The chapters are written by well-recognized experts in appropriate fields, peer reviewed, and edited by physicians and scientists with extensive expertise in space medical operations and space-related biomedical research. As Space Exploration continues the major question whether humans are capable of adapting to long term presence and adequate functioning in space habitats remains to be answered We expect that the comprehensive review of the medico-biological results of the SSP along with the data collected during the missions on the space stations (Mir and ISS) provides a good starting point in seeking the answer to this question.

Microbial Monitoring of Crewed Habitats in Space—Current Status and Future Perspectives

PubMed Central

Yamaguchi, Nobuyasu; Roberts, Michael; Castro, Sarah; Oubre, Cherie; Makimura, Koichi; Leys, Natalie; Grohmann, Elisabeth; Sugita, Takashi; Ichijo, Tomoaki; Nasu, Masao

2014-01-01

Previous space research conducted during short-term flight experiments and long-term environmental monitoring on board orbiting space stations suggests that the relationship between humans and microbes is altered in the crewed habitat in space. Both human physiology and microbial communities adapt to spaceflight. Microbial monitoring is critical to crew safety in long-duration space habitation and the sustained operation of life support systems on space transit vehicles, space stations, and surface habitats. To address this critical need, space agencies including NASA (National Aeronautics and Space Administration), ESA (European Space Agency), and JAXA (Japan Aerospace Exploration Agency) are working together to develop and implement specific measures to monitor, control, and counteract biological contamination in closed-environment systems. In this review, the current status of microbial monitoring conducted in the International Space Station (ISS) as well as the results of recent microbial spaceflight experiments have been summarized and future perspectives are discussed. PMID:25130885

Flight projects overview

NASA Technical Reports Server (NTRS)

Levine, Jack

1988-01-01

Information is given in viewgraph form on the activities of the Flight Projects Division of NASA's Office of Aeronautics and Space Technology. Information is given on space research and technology strategy, current space flight experiments, the Long Duration Exposure Facility, the Orbiter Experiment Program, the Lidar In-Space Technology Experiment, the Ion Auxiliary Propulsion System, the Arcjet Flight Experiment, the Telerobotic Intelligent Interface Flight Experiment, the Cryogenic Fluid Management Flight Experiment, the Industry/University In-Space Flight Experiments, and the Aeroassist Flight Experiment.

TDRSS Onboard Navigation System (TONS) flight qualification experiment

NASA Technical Reports Server (NTRS)

Gramling, C. J.; Hart, R. C.; Folta, D. C.; Long, A. C.

1994-01-01

The National Aeronautics and Space Administration (NASA) Goddard Space Flight Center (GSFC) is currently developing an operational Tracking and Data Relay Satellite (TDRS) System (TDRSS) Onboard Navigation System (TONS) to provide realtime, autonomous, high-accuracy navigation products to users of TDRSS. A TONS experiment was implemented on the Explorer Platform/Extreme Ultraviolet Explorer (EP/EUVE) spacecraft, launched June 7, 1992, to flight qualify the TONS operational system using TDRSS forward-link communications services. This paper provides a detailed evaluation of the flight hardware, an ultrastable oscillator (USO) and Doppler extractor (DE) card in one of the TDRSS user transponders and the ground-based prototype flight software performance, based on the 1 year of TONS experiment operation. The TONS experiment results are used to project the expected performance of the TONS 1 operational system. TONS 1 processes Doppler data derived from scheduled forward-link S-band services using a sequential estimation algorithm enhanced by a sophisticated process noise model to provide onboard orbit and frequency determination and time maintenance. TONS 1 will be the prime navigation system on the Earth Observing System (EOS)-AM1 spacecraft, currently scheduled for launch in 1998. Inflight evaluation of the USO and DE short-term and long-term stability indicates that the performance is excellent. Analysis of the TONS prototype flight software performance indicates that realtime onboard position accuracies of better than 25 meters root-mean-square are achievable with one tracking contact every one to two orbits for the EP/EUVE 525-kilometer altitude, 28.5 degree inclination orbit. The success of the TONS experiment demonstrates the flight readiness of TONS to support the EOS-AM1 mission.

Space Photovoltaic Research and Technology, 1989

NASA Technical Reports Server (NTRS)

1991-01-01

Remarkable progress on a wide variety of approaches in space photovoltaics, for both near and far term applications is reported. Papers were presented in a variety of technical areas, including multi-junction cell technology, GaAs and InP cells, system studies, cell and array development, and non-solar direct conversion. Five workshops were held to discuss the following topics: mechanical versus monolithic multi-junction cells; strategy in space flight experiments; non-solar direct conversion; indium phosphide cells; and space cell theory and modeling.

The MISSE-9 Polymers and Composites Experiment Being Flown on the MISSE-Flight Facility

NASA Technical Reports Server (NTRS)

De Groh, Kim K.; Banks, Bruce A.

2017-01-01

Materials on the exterior of spacecraft in low Earth orbit (LEO) are subject to extremely harsh environmental conditions, including various forms of radiation (cosmic rays, ultraviolet, x-ray, and charged particle radiation), micrometeoroids and orbital debris, temperature extremes, thermal cycling, and atomic oxygen (AO). These environmental exposures can result in erosion, embrittlement and optical property degradation of susceptible materials, threatening spacecraft performance and durability. To increase our understanding of space environmental effects such as AO erosion and radiation induced embrittlement of spacecraft materials, NASA Glenn has developed a series of experiments flown as part of the Materials International Space Station Experiment (MISSE) missions on the exterior of the International Space Station (ISS). These experiments have provided critical LEO space environment durability data such as AO erosion yield values for many materials and mechanical properties changes after long term space exposure. In continuing these studies, a new Glenn experiment has been proposed, and accepted, for flight on the new MISSE-Flight Facility (MISSE-FF). This experiment is called the Polymers and Composites Experiment and it will be flown as part of the MISSE-9 mission, the inaugural mission of MISSE-FF. Figure 1 provides an artist rendition of MISSE-FF ISS external platform. The MISSE-FF is manifested for launch on SpaceX-13.

Human-Rated Space Vehicle Backup Flight Systems

NASA Technical Reports Server (NTRS)

Davis, Jeffrey A.; Busa, Joseph L.

2004-01-01

Human rated space vehicles have historically employed a Backup Flight System (BFS) for the main purpose of mitigating the loss of the primary avionics control system. Throughout these projects, however, the underlying philosophy and technical implementation vary greatly. This paper attempts to coalesce each of the past space vehicle program's BFS design and implementation methodologies with the accompanying underlining philosophical arguments that drove each program to such decisions. The focus will be aimed at Mercury, Gemini, Apollo, and Space Shuttle However, the ideologies and implementation of several commercial and military aircraft are incorporated as well to complete the full breadth view of BFS development across the varying industries. In particular to the non-space based vehicles is the notion of deciding not to utilize a BFS. A diverse analysis of BFS to primary system benefits in terms of reliability against all aspects of project development are reviewed and traded. The risk of engaging the BFS during critical stages of flight (e.g. ascent and entry), the level of capability of the BFS (subset capability of main system vs. equivalent system), and the notion of dissimilar hardware and software design are all discussed. Finally, considerations for employing a BFS on future human-rated space missions are reviewed in light of modern avionics architectures and mission scenarios implicit in exploration beyond low Earth orbit.

Medical concerns for exploration-class missions

NASA Technical Reports Server (NTRS)

Stewart, Donald F.; Lujan, Barbara

1991-01-01

The Space Exploration initiative will challenge life scientists with a diverse set of crew medical risks. The varied sources of this cumulative risk are identified and briefly discussed in terms of risk assessment and preliminary plans for risk management. The roles of Space Station Freedom and other flight programs are discussed in the context of exploration medical objectives. The significant differences between Space Station era (second generation) and exploration medical support systems (third generation) are reviewed.

Habituation to novel visual vestibular environments with special reference to space flight

NASA Technical Reports Server (NTRS)

Young, L. R.; Kenyon, R. V.; Oman, C. M.

1981-01-01

The etiology of space motion sickness and the underlying physiological mechanisms associated with spatial orientation in a space environment were investigated. Human psychophysical experiments were used as the basis for the research concerning the interaction of visual and vestibular cues in the development of motion sickness. Particular emphasis is placed on the conflict theory in terms of explaining these interactions. Research on the plasticity of the vestibulo-ocular reflex is discussed.

The effect of space radiation on the induction of chromosome damage

NASA Technical Reports Server (NTRS)

George, K.; Wu, H.; Willingham, V.; Cucinotta, F. A.

2001-01-01

To obtain information on the cytogenetic damage caused by space radiation, chromosome exchanges in lymphocytes from crewmembers of long-term Mir missions, and a shorter duration shuttle mission, were examined using fluorescence in situ hybridization. A significant increase in chromosomal aberrations was observed after the long duration flights. The ratio of aberrations identified as complex was higher post-flight for some crewmembers, which is thought to be an indication of exposure to high-LET radiation. Ground-based studies have shown that the frequency of aberrations measured post-flight could be influenced by a mitotic delay in cells damaged by high-LET radiation and this effect could lower biological dose estimates. To counteract this effect, prematurely condensed chromosome (PCC) spreads were collected. Frequencies of aberrations in PCC were compared with those in metaphase spreads.

Long-term exposure to space's microgravity alters the time structure of heart rate variability of astronauts.

PubMed

Otsuka, Kuniaki; Cornelissen, Germaine; Furukawa, Satoshi; Kubo, Yutaka; Hayashi, Mitsutoshi; Shibata, Koichi; Mizuno, Koh; Aiba, Tatsuya; Ohshima, Hiroshi; Mukai, Chiaki

2016-12-01

Spaceflight alters human cardiovascular dynamics. The less negative slope of the fractal scaling of heart rate variability (HRV) of astronauts exposed long-term to microgravity reflects cardiovascular deconditioning. We here focus on specific frequency regions of HRV. Ten healthy astronauts (8 men, 49.1 ± 4.2 years) provided five 24-hour electrocardiographic (ECG) records: before launch, 20.8 ± 2.9 (ISS01), 72.5 ± 3.9 (ISS02) and 152.8 ± 16.1 (ISS03) days after launch, and after return to Earth. HRV endpoints, determined from normal-to-normal (NN) intervals in 180-min intervals progressively displaced by 5 min, were compared in space versus Earth. They were fitted with a model including 4 major anticipated components with periods of 24 (circadian), 12 (circasemidian), 8 (circaoctohoran), and 1.5 (Basic Rest-Activity Cycle; BRAC) hours. The 24-, 12-, and 8-hour components of HRV persisted during long-term spaceflight. The 90-min amplitude became about three times larger in space (ISS03) than on Earth, notably in a subgroup of 7 astronauts who presented with a different HRV profile before flight. The total spectral power (TF; p < 0.05) and that in the ultra-low frequency range (ULF, 0.0001-0.003 Hz; p < 0.01) increased from 154.9 ± 105.0 and 117.9 ± 57.5 msec 2 (before flight) to 532.7 ± 301.3 and 442.4 ± 202.9 msec 2 (ISS03), respectively. The power-law fractal scaling β was altered in space, changing from -1.087 ± 0.130 (before flight) to -0.977 ± 0.098 (ISS01), -0.910 ± 0.130 (ISS02), and -0.924 ± 0.095 (ISS03) (invariably p < 0.05). Most HRV changes observed in space relate to a frequency window centered around one cycle in about 90 min. Since the BRAC component is amplified in space for only specific HRV endpoints, it is likely to represent a physiologic response rather than an artifact from the International Space Station (ISS) orbit. If so, it may offer a way to help adaptation to microgravity during long-duration spaceflight.

User's instructions for the whole-body algorithms

NASA Technical Reports Server (NTRS)

Grounds, D. J.; Fitzjerrell, D. G.; Leonard, J. I.; Marks, V. J.

1975-01-01

The design of an algorithm that provides for the simulation of long and short term biological stresses is reported. The physiological responses of models representing circulatory, respiratory, cardiovascular, and thermoregulatory systems during space flight simulation are described.

14 CFR 460.51 - Space flight participant training.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Space flight participant training. 460.51 Section 460.51 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING HUMAN SPACE FLIGHT REQUIREMENTS Launch and Reentry with a Space Flight...

14 CFR 460.51 - Space flight participant training.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Space flight participant training. 460.51 Section 460.51 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING HUMAN SPACE FLIGHT REQUIREMENTS Launch and Reentry with a Space Flight...

14 CFR 460.51 - Space flight participant training.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Space flight participant training. 460.51 Section 460.51 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING HUMAN SPACE FLIGHT REQUIREMENTS Launch and Reentry with a Space Flight...

14 CFR 460.51 - Space flight participant training.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Space flight participant training. 460.51 Section 460.51 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING HUMAN SPACE FLIGHT REQUIREMENTS Launch and Reentry with a Space Flight...

14 CFR 460.51 - Space flight participant training.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Space flight participant training. 460.51 Section 460.51 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING HUMAN SPACE FLIGHT REQUIREMENTS Launch and Reentry with a Space Flight...

Orion Powered Flight Guidance Burn Options for Near Term Exploration

NASA Technical Reports Server (NTRS)

Fill, Tom; Goodman, John; Robinson, Shane

2018-01-01

NASA's Orion exploration spacecraft will fly more demanding mission profiles than previous NASA human flight spacecraft. Missions currently under development are destined for cislunar space. The EM-1 mission will fly unmanned to a Distant Retrograde Orbit (DRO) around the Moon. EM-2 will fly astronauts on a mission to the lunar vicinity. To fly these missions, Orion requires powered flight guidance that is more sophisticated than the orbital guidance flown on Apollo and the Space Shuttle. Orion's powered flight guidance software contains five burn guidance options. These five options are integrated into an architecture based on a proven shuttle heritage design, with a simple closed-loop guidance strategy. The architecture provides modularity, simplicity, versatility, and adaptability to future, yet-to-be-defined, exploration mission profiles. This paper provides a summary of the executive guidance architecture and details the five burn options to support both the nominal and abort profiles for the EM-1 and EM-2 missions.

Orion's Powered Flight Guidance Burn Options for Near Term Exploration Missions

NASA Technical Reports Server (NTRS)

Fill, Thomas; Goodman, John; Robinson, Shane

2018-01-01

NASA's Orion exploration spacecraft will fly more demanding mission profiles than previous NASA human flight spacecraft. Missions currently under development are destined for cislunar space. The EM-1 mission will fly unmanned to a Distant Retrograde Orbit (DRO) around the Moon. EM-2 will fly astronauts on a mission to the lunar vicinity. To fly these missions, Orion requires powered flight guidance that is more sophisticated than the orbital guidance flown on Apollo and the Space Shuttle. Orion's powered flight guidance software contains five burn guidance options. These five options are integrated into an architecture based on a proven shuttle heritage design, with a simple closed-loop guidance strategy. The architecture provides modularity, simplicity, versatility, and adaptability to future, yet-to-be-defined, exploration mission profiles. This paper provides a summary of the executive guidance architecture and details the five burn options to support both the nominal and abort profiles for the EM-1 and EM-2 missions.

NASA Space Biology Plant Research for 2010-2020

NASA Technical Reports Server (NTRS)

Levine, H. G.; Tomko, D. L.; Porterfield, D. M.

2012-01-01

The U.S. National Research Council (NRC) recently published "Recapturing a Future for Space Exploration: Life and Physical Sciences Research for a New Era" (http://www.nap.edu/catalog.php?record id=13048), and NASA completed a Space Biology Science Plan to develop a strategy for implementing its recommendations ( http://www.nasa.gov/exploration/library/esmd documents.html). The most important recommendations of the NRC report on plant biology in space were that NASA should: (1) investigate the roles of microbial-plant systems in long-term bioregenerative life support systems, and (2) establish a robust spaceflight program of research analyzing plant growth and physiological responses to the multiple stimuli encountered in spaceflight environments. These efforts should take advantage of recently emerged analytical technologies (genomics, transcriptomics, proteomics, metabolomics) and apply modern cellular and molecular approaches in the development of a vigorous flight-based and ground-based research program. This talk will describe NASA's strategy and plans for implementing these NRC Plant Space Biology recommendations. New research capabilities for Plant Biology, optimized by providing state-of-the-art automated technology and analytical techniques to maximize scientific return, will be described. Flight experiments will use the most appropriate platform to achieve science results (e.g., ISS, free flyers, sub-orbital flights) and NASA will work closely with its international partners and other U.S. agencies to achieve its objectives. One of NASA's highest priorities in Space Biology is the development research capabilities for use on the International Space Station and other flight platforms for studying multiple generations of large plants. NASA will issue recurring NASA Research Announcements (NRAs) that include a rapid turn-around model to more fully engage the biology community in designing experiments to respond to the NRC recommendations. In doing so, NASA's Space Biology research will optimize ISS research utilization, develop and demonstrate technology and hardware that will enable new science, and contribute to the base of fundamental knowledge that will facilitate development of new tools for human space exploration and Earth applications. By taking these steps, NASA will energize the Space Biology user community and advance our knowledge of the effect of the space flight environment on living systems.

Microbiological assay of the Marshall Space Flight Center neutral buoyancy simulator

NASA Technical Reports Server (NTRS)

Beyerle, F. J.

1973-01-01

A neutral buoyancy simulator tank system is described in terms of microbiological and medical safety for astronauts. The system was designed to simulate a gravity-free state for evaluation of orbital operations in a microorganism-free environment. Methods for the identification and elimination of specific microorganisms are dealt with as measures for a pure system of space environment simulation.

Effect of Real and Simulated Microgravity on Muscle Function

NASA Technical Reports Server (NTRS)

1997-01-01

In this session, Session JA3, the discussion focuses on the following topics: Changes in Calf Muscle Performance, Energy Metabolism, and Muscle Volume Caused by Long Term Stay on Space Station MIR; Vibrografic Signs of Autonomous Muscle Tone Studied in Long Term Space Missions; Reduction of Muscle Strength After Long Duration Space Flights is Associated Primarily with Changes in Neuromuscular Function; The Effects of a 115-Day Spaceflight on Neuromuscular Function in Crewman; Effects of 17-Day Spaceflight on Human Triceps Surae Electrically-Evoked Contractions; Effects of Muscle Unloading on EMG Spectral Parameters; and Myofiber Wound-Mediated FGF Release and Muscle Atrophy During Bedrest.

Influence of spaceflight on the efficiency of tomatoes quality and plant resistance to viral infection

NASA Astrophysics Data System (ADS)

Dashchenko, Anna; Mishchenko, Lidiya

Tomatoes are an important agricultural crop. The use of plants for life support in long-term space flight advances multiple problems - an adaptation to microgravity and taste. Conditions of microgravity are stressful for plants and they cause them adaptation syndrome to protect and preserve homeostasis (Kordyum, 2010, 2012;. Hasenstein, 1999). Tomatoes are also a product of the diet of astronauts, which is an important part of their life - the regeneration gas environment (photosynthesis), the relaxation factor in psychological people and a powerful antioxidant. In 2007, the tomato seeds, genetically created by scientists from the University of North Carolina, was placed on the International Space Station. But the experiment failed because the seedlings died (Khodakovskaya). Although researchers do not bind this fact with microgravity, it is clear that the study of this factor on plants is rather important. Therefore, the study of the effect of space flight conditions on plant species continues. The aim of our study was to investigate the effect of space flight on tomato plant resistance to viral infection and quality products. Seeds of tomato plants (Lycopersicon esculentum Mill., Sort Podmoskovny early) 6 years (1992-1998) were in terms of long-term space flight on the Russian space station "Mir". Then the seeds germinated in the spring of 2011 and grew up in the Earth's field on the natural infectious background. Part of the plants underwent 5 reproductive phase, resulting in 2011 investigated tomatoes from seed 1st and 5th reproduction, in 2012 - the second and sixth, respectively, and in 2013 - as the second and sixth (sow seeds obtained by us in the Ukraine in 2011.) In our research we used two controls: 1 (stationary control) - plants of the first generation seeds which were not in outer space; 2 - five plants from seed reproduction that exhibited in space and were grown in parallel under the same conditions of the studied plants. Defining of β-carotene and lycopene was performed spectralphotometrical (Mapada UV-1600, China) at wavelengths between 451 nm and 503 nm using hexane. The content of phenolic compounds in tomato fruits was determined by the method (Kondratenko et al .., 2008) on spectrophotometer KFK-3-0,1 at a wavelength of 640 nm. Assessment of the reliability of differences between groups was determined by Student's test. Our attention was brought back in on itself by the fact that the smallest content of pigments in plants was of the seed of the 5th Reproduction : compared with stationary control - 1.7 times (carotene) and 2.3 times (lycopene) from plants seeds that were in space flight - 2.3 and 4.1 times. Because the plants were grown in the field in natural infectious background, there was a high probability of their defeat pathogens of different nature, including viruses. Many authors proven to reduce the concentration of carotene and lycopene in tomatoes with lesions of viruses (Raithak, 2012). In addition, the control plants with symptoms characteristic to those that cause viral infection, namely in 2011 - curling leaves of the "hook-up" in 2012 - except for leaf curl and mosaic back. The research results were confirmed in 2013, namely on the plants of "space" seeds no symptoms of and in control - detection of potato virus Y- Method (RT-PCR) and symptoms of leaf curl and mosaic. Results of the analyzes show that most of polyphenolic compounds contained in fruits of tomatoes, grown from "space" seeds (122 mg /100g). In the steady state control - 114 mg /100 g in the control number 2 - 84 mg /100 g (p <0.01). Numerous studies have shown that a large number of phenolic compounds toxic to a variety of pathogens, including viruses. It was established in response to infection polyphenol content increases, and the stronger, the higher the resistance of plants to pathogens (Gladun etc. .., 2011). In other words, the factors of space flight increase resistance to infection by viruses, as evidenced by the external symptoms, ELISA, EM, RT-PCR, which showed that in contrast to the controls, plants with "space" seeds 1-2 reproductions less affected or not at all infected with viruses that can Explain the high content of polyphenolic compounds. Thus, we found that spaceflight factors significantly affect tomato plants. They increase the productivity of plants, the concentration of carotenoids in fruits (β-carotene and lycopene), which is important for the use of these plants as food for astronauts on long-term space missions. Second, plants grown from seeds that were in space, are resistant to infection by viruses and are characterized by a high content of polyphenols, despite the long-term storage at rest.

A high-performance photovoltaic concentrator array - The mini-dome Fresnel lens concentrator with 30 percent efficient GaAs/GaSb tandem cells

NASA Technical Reports Server (NTRS)

Piszczor, M. F.; Brinker, D. J.; Flood, D. J.; Avery, J. E.; Fraas, L. M.; Fairbanks, E. S.; Yerkes, J. W.; O'Neill, M. J.

1991-01-01

A high-efficiency, lightweight space photovoltaic concentrator array is described. Previous work on the minidome Fresnel lens concentrator concept is being integrated with Boeing's 30 percent efficient tandem GaAs/GaSb concentrator cells into a high-performance photovoltaic array. Calculations indicate that, in the near term, such an array can achieve 300 W/sq m at a specific power of 100 W/kg. Emphasis of the program has now shifted to integrating the concentrator lens, tandem cell, and supporting panel structure into a space-qualifiable array. A description is presented of the current status of component and prototype panel testing and the development of a flight panel for the Photovoltaic Array Space Power Plus Diagnostics (PASP PLUS) flight experiment.

Increased intracranial pressure in mini-pigs exposed to simulated solar particle event radiation

NASA Astrophysics Data System (ADS)

Sanzari, Jenine K.; Muehlmatt, Amy; Savage, Alexandria; Lin, Liyong; Kennedy, Ann R.

2014-02-01

Changes in intracranial pressure (ICP) during space flight have stimulated an area of research in space medicine. It is widely speculated that elevations in ICP contribute to structural and functional ocular changes, including deterioration in vision, which is also observed during space flight. The aim of this study was to investigate changes in opening pressure (OP) occurring as a result of ionizing radiation exposure (at doses and dose-rates relevant to solar particle event radiation). We used a large animal model, the Yucatan mini-pig, and were able to obtain measurements over a 90 day period. This is the first investigation to show long term recordings of ICP in a large animal model without an invasive craniotomy procedure. Further, this is the first investigation reporting increased ICP after radiation exposure.

A high-performance photovoltaic concentrator array - The mini-dome Fresnel lens concentrator with 30 percent efficient GaAs/GaSb tandem cells

NASA Astrophysics Data System (ADS)

Piszczor, M. F.; Brinker, D. J.; Flood, D. J.; Avery, J. E.; Fraas, L. M.; Fairbanks, E. S.; Yerkes, J. W.; O'Neill, M. J.

A high-efficiency, lightweight space photovoltaic concentrator array is described. Previous work on the minidome Fresnel lens concentrator concept is being integrated with Boeing's 30 percent efficient tandem GaAs/GaSb concentrator cells into a high-performance photovoltaic array. Calculations indicate that, in the near term, such an array can achieve 300 W/sq m at a specific power of 100 W/kg. Emphasis of the program has now shifted to integrating the concentrator lens, tandem cell, and supporting panel structure into a space-qualifiable array. A description is presented of the current status of component and prototype panel testing and the development of a flight panel for the Photovoltaic Array Space Power Plus Diagnostics (PASP PLUS) flight experiment.

Regulating private human suborbital flight at the international and European level: Tendencies and suggestions

NASA Astrophysics Data System (ADS)

Masson-Zwaan, Tanja; Moro-Aguilar, Rafael

2013-12-01

In the context of the FAST20XX project (Future High-Altitude High-Speed Transport) that started in 2009 under the 7th Framework Programme of the European Union (EU), the authors reexamined the legal status of private human suborbital flight, and researched whether it might be regulated as aviation or as spaceflight. International space law is ambiguous as to accommodating suborbital activities. While some provisions of the UN outer space treaties would seem to exclude them, generally there is not any explicit condition in terms of reaching orbit as a requirement for application. International air law presents equal difficulties in dealing with this activity. The classic definition of "aircraft" as contained in the Annexes to the Chicago Convention does not really encompass the kind of rocket-powered vehicles that are envisaged here. As a result, it is unclear whether the United Nations Committee on the Peaceful Uses of Outer Space (COPUOS), the International Civil Aviation Organization (ICAO), or both could be involved in an eventual international regulation of suborbital flight. In the absence of a uniform international regime, each state has the sovereign right to regulate human suborbital flights operating within its airspace. So far, two practical solutions have been realised or proposed, and will be analyzed. On the one hand, the USA granted power for regulation and licensing over private human suborbital flight to the Office of Commercial Space Transportation of the Federal Aviation Administration (FAA/AST). Subsequent regulations by the FAA have set out a series of requirements for companies that want to operate these flights, enabling a market to develop. On the other side of the Atlantic, both the European Space Agency (ESA) and a group of representatives of the European Aviation Safety Agency (EASA) of the European Union (EU) seem to rather regard this activity as aviation, potentially subject to the regulation and certification competences of EASA, although recent developments may indicate a changed view. Due to these differences, it is uncertain when this activity will be considered aviation and when it will be considered as spaceflight. However, the characterization as either of these has important consequences for the industry and for a stable regulatory landscape. In the longer term, from an international and a European perspective, the best solution for regulation may be to create a sui generis legal regime specifically addressing the particular nature of suborbital flight. Suborbital transportation is neither aviation nor spaceflight; it is rather something in between. A new legal regime would be able to combine notions of both air and space law, in order to overcome and resolve the current deficiencies of each discipline.

The relationship between dietary intake, exercise, energy balance and the space craft environment

NASA Technical Reports Server (NTRS)

Stein, T. P.

2000-01-01

Space flight is associated with the loss of skeletal muscle, principally from muscles with anti-gravity functions. Examination of data across different missions can permit a distinction to be made between true microgravity responses and what are mission-specific responses. Protein metabolism has been investigated on six missions, four short-term [Shuttle missions Space Life Sciences 1 (1991, SLSI), Space Life Sciences 2 (1993, SLS2), Deutsche-2 (1993, D2) and the Life and Microgravity Sciences (1996, LMS)] and two long-term missions (Skylab 1993 and NASA/MIR, 1996-1998). Measurements made include dietary intake (six missions), nitrogen balance (four missions), whole-body protein kinetics with [15N]glycine as the tracer (four missions) and cortisol excretion (three missions). Also available for comparison are bed rest studies with and without exercise. The purpose of this paper is to see what can be learnt about the muscle loss problem by comparing metabolic results across the six missions for which data are available and against bed rest. The analysis suggests that there is a linkage between the inability to maintain energy balance and exercise, and the connection is the decreased efficiency of removal of the metabolic by-products of exercise (heat, CO2) during space flight.

SCORPI and SCORPI-T: Neurophysiological experiments on animals in space

NASA Astrophysics Data System (ADS)

Serafini, L.; Ramacciotti, T.; Vigano, W.; Donati, A.; Porciani, M.; Zolesi, V.; Schulze-Varnholt, D.; Manieri, P.; El-Din Sallam, A.; Schmah, M.; Horn, E. R.

2005-08-01

The study of physiological adaptation to long-term space flights with special consideration of the internal clock systems of scorpions is the goal of the SCORPI and SCORPI-T experiments. SCORPI was selected for flight on the International Space Station (ISS) and will be mounted in the European facility BIOLAB, the ESA laboratory designed to support biological experiments on micro-organisms, cells, tissue, cultures, small plants and small invertebrates. SCORPI-T experiment, performed on the Russian FOTON-M2 satellite in May-June 2005, represents an important precursor for the success of the experiment SCORPI on BIOLAB. This paper outlines the main features of the hardware designed and developed in order to allow the analysis of critical aspects of experiment execution and the verification of experiment objectives. The capabilities of the hardware developed for SCORPI and SCORPI-T show its potential use for any future similar type of experiments in space.

Space adaptation syndrome: multiple etiological factors and individual differences

NASA Technical Reports Server (NTRS)

Lackner, J. R.; DiZio, P.

1991-01-01

Space motion sickness is a significant operational concern in the American and Soviet space programs. Nearly 70% of all astronauts and cosmonauts are affected to some degree during their first several days of flight. It is now beginning to appear that space motion sickness like terrestrial motion sickness is the consequence of multiple etiological factors. As we come to understand basic mechanisms of spatial orientation and sensory-motor adaptation we can begin to predict etiological factors in different motion environments. Individuals vary greatly in the extent to which they are susceptible to these different factors. However, individuals seem to be relatively self-consistent in terms of their rates of adaptation to provocative stimulation and their retention of adaptation. Attempts to relate susceptibility to motion sickness during the microgravity phases of parabolic flight maneuvers to vestibular function under 1G and 0G test conditions are described.

Utilization of sounding rockets and balloons in the German Space Programme

NASA Astrophysics Data System (ADS)

Preu, Peter; Friker, Achim; Frings, Wolfgang; Püttmann, Norbert

2005-08-01

Sounding rockets and balloons are important tools of Germany's Space Programme. DLR manages these activities and promotes scientific experiments and validation programmes within (1) Space Science, (2) Earth Observation, (3) Microgravity Research and (4) Re-entry Technologies (SHEFEX). In Space Science the present focus is at atmospheric research. Concerning Earth Observation balloon-borne measurements play a key role in the validation of atmospheric satellite sounders (ENVISAT). TEXUS and MAXUS sounding rockets are successfully used for short duration microgravity experiments. The Sharp Edge Flight Experiment SHEFEX will deliver data from a hypersonic flight for the validation of a new Thermal Protection System (TPS), wind tunnel testing and numerical analysis of aerothermodynamics. Signing the Revised Esrange and Andøya Special Project (EASP) Agreement 2006-2010 in June 2004 Germany has made an essential contribution to the long-term availability of the Scandinavian ranges for the European science community.

Red Dragon-MSL Hybrid Landing Architecture for 2018

NASA Astrophysics Data System (ADS)

Grover, M. R.; Sklyanskiy, E.; Stelzner, A. D.; Sherwood, B.

2012-06-01

Hybridizing modern developments at SpaceX and JPL could enable landing 1 metric ton-class payloads on Mars for of order $250M, beginning in 2018. Near term, OCT could perform Earth-based flight demonstration of supersonic retropropulsion.

Cognitive Neuroscience in Space

PubMed Central

De la Torre, Gabriel G.

2014-01-01

Humans are the most adaptable species on this planet, able to live in vastly different environments on Earth. Space represents the ultimate frontier and a true challenge to human adaptive capabilities. As a group, astronauts and cosmonauts are selected for their ability to work in the highly perilous environment of space, giving their best. Terrestrial research has shown that human cognitive and perceptual motor performances deteriorate under stress. We would expect to observe these effects in space, which currently represents an exceptionally stressful environment for humans. Understanding the neurocognitive and neuropsychological parameters influencing space flight is of high relevance to neuroscientists, as well as psychologists. Many of the environmental characteristics specific to space missions, some of which are also present in space flight simulations, may affect neurocognitive performance. Previous work in space has shown that various psychomotor functions degrade during space flight, including central postural functions, the speed and accuracy of aimed movements, internal timekeeping, attentional processes, sensing of limb position and the central management of concurrent tasks. Other factors that might affect neurocognitive performance in space are illness, injury, toxic exposure, decompression accidents, medication side effects and excessive exposure to radiation. Different tools have been developed to assess and counteract these deficits and problems, including computerized tests and physical exercise devices. It is yet unknown how the brain will adapt to long-term space travel to the asteroids, Mars and beyond. This work represents a comprehensive review of the current knowledge and future challenges of cognitive neuroscience in space from simulations and analog missions to low Earth orbit and beyond. PMID:25370373

Columbia: The first five flights entry heating data series. Volume 4: The lower windward wing 50 percent and 80 percent semispans

NASA Technical Reports Server (NTRS)

Williams, S. D.

1983-01-01

Entry heating flight data and wind tunnel data on the lower wing 50% and 80% Semi-Spans are presented for the first five flights of the Space Shuttle Orbiter. The heating rate data is presented in terms of normalized film heat transfer coefficients as a function of angle-of-attack, Mach number, and Normal Shock Reynolds number. The surface heating rates and temperatures were obtained via the JSC NONLIN/INVERSE computer program. Time history plots of the surface heating rates and temperatures are also presented.

Columbia: The first 5 flights entry heating data series. Volume 1: An overview

NASA Technical Reports Server (NTRS)

Williams, S. D.

1984-01-01

Entry heating flight data and wind tunnel data on the lower windward and upper lee side centerline, lower wing 50% and 80% semi-spans, side fuselage and payload bay door, Z-400 and 440 trace aft of X/L=0.2, and OMS Pod trace 3, are presented for the first five flights of the space shuttle orbiter. Heating rate distributions are presented in terms of normalized shock Reynolds number to show the sensitivity of heating to these parameters. The surface heating rates and temperatures were obtained via the JSC NONLIN/INVERSE computer program.

Third Conference on Fibrous Composites in Flight Vehicle Design, part 1

NASA Technical Reports Server (NTRS)

1976-01-01

The use of fibrous composite materials in the design of aircraft and space vehicle structures and their impact on future vehicle systems are discussed. The topics covered include: flight test work on composite components, design concepts and hardware, specialized applications, operational experience, certification and design criteria. Contributions to the design technology base include data concerning material properties, design procedures, environmental exposure effects, manufacturing procedures, and flight service reliability. By including composites as baseline design materials, significant payoffs are expected in terms of reduced structural weight fractions, longer structural life, reduced fuel consumption, reduced structural complexity, and reduced manufacturing cost.

Computer Model Predicts the Movement of Dust

NASA Technical Reports Server (NTRS)

2002-01-01

A new computer model of the atmosphere can now actually pinpoint where global dust events come from, and can project where they're going. The model may help scientists better evaluate the impact of dust on human health, climate, ocean carbon cycles, ecosystems, and atmospheric chemistry. Also, by seeing where dust originates and where it blows people with respiratory problems can get advanced warning of approaching dust clouds. 'The model is physically more realistic than previous ones,' said Mian Chin, a co-author of the study and an Earth and atmospheric scientist at Georgia Tech and the Goddard Space Flight Center (GSFC) in Greenbelt, Md. 'It is able to reproduce the short term day-to-day variations and long term inter-annual variations of dust concentrations and distributions that are measured from field experiments and observed from satellites.' The above images show both aerosols measured from space (left) and the movement of aerosols predicted by computer model for the same date (right). For more information, read New Computer Model Tracks and Predicts Paths Of Earth's Dust Images courtesy Paul Giroux, Georgia Tech/NASA Goddard Space Flight Center

Human System Drivers for Exploration Missions

NASA Technical Reports Server (NTRS)

Kundrot, Craig E.; Steinberg, Susan; Charles, John B.

2010-01-01

Evaluation of DRM4 in terms of the human system includes the ability to meet NASA standards, the inclusion of the human system in the design trade space, preparation for future missions and consideration of a robotic precursor mission. Ensuring both the safety and the performance capability of the human system depends upon satisfying NASA Space Flight Human System Standards.1 These standards in turn drive the development of program-specific requirements for Near-earth Object (NEO) missions. In evaluating DRM4 in terms of these human system standards, the currently existing risk models, technologies and biological countermeasures were used. A summary of this evaluation is provided below in a structure that supports a mission architecture planning activities. 1. Unacceptable Level of Risk The duration of the DRM4 mission leads to an unacceptable level of risk for two aspects of human system health: A. The permissible exposure limit for space flight radiation exposure (a human system standard) would be exceeded by DRM4. B. The risk of visual alterations and abnormally high intracranial pressure would be too high. 1

NASA Space Cryocooler Programs: A 2003 Overview

NASA Technical Reports Server (NTRS)

Ross, R. G., Jr.; Boyle, R. F.; Kittel, P.

2004-01-01

Mechanical cryocoolers represent a significant enabling technology for NASA's Earth and Space Science missions. An overview is presented of ongoing cryocooler activities within NASA in support of current flight projects, near-term flight instruments, and long-term technology development. NASA programs in Earth and space science observe a wide range of phenomena, from crop dynamics to stellar birth. Many of the instruments require cryogenic refrigeration to improve dynamic range, extend wavelength coverage, and enable the use of advanced detectors. Although, the largest utilization of coolers over the last decade has been for instruments operating at medium to high cryogenic temperatures (55 to 150 K), reflecting the relative maturity of the technology at these temperatures, important new developments are now focusing at the lower temperature range from 4 to 20 K in support of studies of the origin of the universe and the search for planets around distant stars. NASA's development of a 20K cryocooler for the European Planck spacecraft and its new Advanced Cryocooler Technology Development Program (ACTDP) for 6-18 K coolers are examples of the thrust to provide low temperature cooling for this class of missions.

Computational Aerothermodynamic Assessment of Space Shuttle Orbiter Tile Damage: Open Cavities

NASA Technical Reports Server (NTRS)

Pulsonetti, Maria; Wood, William

2005-01-01

Computational aerothermodynamic simulations of Orbiter windside tile damage in flight were performed in support of the Space Shuttle Return-to-Flight effort. The simulations were performed for both hypervelocity flight and low-enthalpy wind tunnel conditions and contributed to the Return-to-Flight program by providing information to support a variety of damage scenario analyses. Computations at flight conditions were performed at or very near the peak heating trajectory point for multiple damage scenarios involving damage windside acreage reaction cured glass (RCG) coated silica tile(s). The cavities formed by the missing tile examined in this study were relatively short leading to flow features which indicated open cavity behavior. Results of the computations indicated elevated heating bump factor levels predicted for flight over the predictions for wind tunnel conditions. The peak heating bump factors, defined as the local heating to a reference value upstream of the cavity, on the cavity floor for flight simulation were 67% larger than the peak wind tunnel simulation value. On the downstream face of the cavity the flight simulation values were 60% larger than the wind tunnel simulation values. On the outer mold line (OML) downstream of the cavity, the flight values are about 20% larger than the wind tunnel simulation values. The higher heating bump factors observed in the flight simulations were due to the larger driving potential in terms of energy entering the cavity for the flight simulations. This is evidenced by the larger rate of increase in the total enthalpy through the boundary layer prior to the cavity for the flight simulation.

Space Environment Effects on Stability of Medications Flown on Space Shuttles and the International Space Station (ISS)

NASA Technical Reports Server (NTRS)

Daniels, Vernie; Du, Jianping; Crady, Camille; Satterfield, Rick; Putcha, Lakshmi

2007-01-01

The purpose is to assess physical and chemical degradation of select pharmaceutical formulations from the Shuttle and ISS medical kits. Eleven pharmaceuticals dispensed as different dosage forms were selected based on their physical / chemical characteristics and susceptibility to environmental factors such as, temperature, humidity and light sensitivity. When available, ground-controls of the study medications with matching brand and lot numbers were used for comparison. Samples retrieved from flight were stored along with their matching controls in a temperature and humidity controlled environmental chamber. Temperature, humidity, and radiation data from the Shuttle and ISS were retrieved from onboard HOBO U12 Temp/RH Data Loggers, and from passive dosimeters. Physical and chemical analyses of the pharmaceuticals were conducted using validated United States Pharmacopeia (USP) methods. Results indicated degradation of 6 of the 11 formulations returned from space flights. Four formulations, Amoxicillin / Clavulanate, promethazine, sulfamethoxazole / trimethoprim, and ciprofloxacin tablets depicted discoloration after flight. Chemical content analyses using High or Ultra Performance Liquid Chromatography (HPLC / UPLC) methods revealed that dosage forms of Amoxicillin / Clavulanate, promethazine, sulfamethoxazole / trimethoprim, lidocaine, ciprofloxacin and mupirocin contained less than 95% of manufacturer s labeled claim of active drug compound. Shuttle and ISS environments affect stability and shelf life of certain mediations flown on these missions. Data analysis is in progress to examine the effect of specific space flight environmental factors on pharmaceutical stability. The degradation profiles generated from ground studies in analog environments will be useful in establishing predictive shelf-life profiles for medications intended for use during long-term space exploration missions.

Cardiovascular and other dynamic systems in long-term space flight

NASA Technical Reports Server (NTRS)

Tipton, David A.

1987-01-01

The paper examines the physiology of the cardiovascular system, and to a lesser extent the endocrine, renal, and hematopoietic systems. The paper highlights the aspects of these areas that are most pertinent to space manufacturing, i.e., working in space. Areas covered include the physiological costs of working in microgravity and partial gravity (e.g., the moon or Mars), countermeasures to potentially adverse physiological adaptations, and problems associated with return to earth after long periods of weightlessness.

Vestibular adaptation to space in monkeys.

PubMed

Dai, M; Raphan, T; Kozlovskaya, I; Cohen, B

1998-07-01

Otolith-induced eye movements of rhesus monkeys were studied before and after the 1989 COSMOS 2044 and the 1992 to 1993 COSMOS 2229 flights. Two animals flew in each mission for approximately 2 weeks. After flight, spatial orientation of the angular vestibulo-ocular reflex was altered. In one animal the time constant of postrotatory nystagmus, which had been shortened by head tilts with regard to gravity before flight, was unaffected by the same head tilts after flight. In another animal, eye velocity, which tended to align with a gravitational axis before flight, moved toward a body axis after flight. This shift of orientation disappeared by 7 days after landing. After flight, the magnitude of compensatory ocular counter-rolling was reduced by about 70% in both dynamic and static tilts. Modulation in vergence in response to naso-occipital linear acceleration during off-vertical axis rotation was reduced by more than 50%. These changes persisted for 11 days after recovery. An up and down asymmetry of vertical nystagmus was diminished for 7 days. Gains of the semicircular canal-induced horizontal and vertical angular vestibulo-ocular reflexes were unaffected in both flights, but the gain of the roll angular vestibulo-ocular reflex was decreased. These data indicate that there are short- and long-term changes in otolith-induced eye movements after adaptation to microgravity. These experiments also demonstrate the unique value of the monkey as a model for studying effects of vestibular adaptation in space. Eye movements can be measured in three dimensions in response to controlled vestibular and visual stimulation, and the results are directly applicable to human beings. Studies in monkeys to determine how otolith afferent input and central processing is altered by adaptation to microgravity should be an essential component of future space-related research.

Vestibular adaptation to space in monkeys

NASA Technical Reports Server (NTRS)

Dai, M.; Raphan, T.; Kozlovskaya, I.; Cohen, B.

1998-01-01

Otolith-induced eye movements of rhesus monkeys were studied before and after the 1989 COSMOS 2044 and the 1992 to 1993 COSMOS 2229 flights. Two animals flew in each mission for approximately 2 weeks. After flight, spatial orientation of the angular vestibulo-ocular reflex was altered. In one animal the time constant of postrotatory nystagmus, which had been shortened by head tilts with regard to gravity before flight, was unaffected by the same head tilts after flight. In another animal, eye velocity, which tended to align with a gravitational axis before flight, moved toward a body axis after flight. This shift of orientation disappeared by 7 days after landing. After flight, the magnitude of compensatory ocular counter-rolling was reduced by about 70% in both dynamic and static tilts. Modulation in vergence in response to naso-occipital linear acceleration during off-vertical axis rotation was reduced by more than 50%. These changes persisted for 11 days after recovery. An up and down asymmetry of vertical nystagmus was diminished for 7 days. Gains of the semicircular canal-induced horizontal and vertical angular vestibulo-ocular reflexes were unaffected in both flights, but the gain of the roll angular vestibulo-ocular reflex was decreased. These data indicate that there are short- and long-term changes in otolith-induced eye movements after adaptation to microgravity. These experiments also demonstrate the unique value of the monkey as a model for studying effects of vestibular adaptation in space. Eye movements can be measured in three dimensions in response to controlled vestibular and visual stimulation, and the results are directly applicable to human beings. Studies in monkeys to determine how otolith afferent input and central processing is altered by adaptation to microgravity should be an essential component of future space-related research.

Space Biotechnology and Commercial Applications University of Florida

NASA Technical Reports Server (NTRS)

Phillips, Winfred; Evanich, Peggy L.

2004-01-01

The Space Biotechnology and Commercial Applications grant was funded by NASA's Kennedy Space Center in FY 2002 to provide dedicated biotechnology and agricultural research focused on the regeneration of space flight environments with direct parallels in Earth-based applications for solving problems in the environment, advances in agricultural science, and other human support issues amenable to targeted biotechnology solutions. This grant had three project areas, each with multiple tasks. They are: 1) Space Agriculture and Biotechnology Research and Education, 2) Integrated Smart Nanosensors for Space Biotechnology Applications, and 3) Commercial Applications. The Space Agriculture and Biotechnology Research and Education (SABRE) Center emphasized the fundamental biology of organisms involved in space flight applications, including those involved in advanced life support environments because of their critical role in the long-term exploration of space. The SABRE Center supports research at the University of Florida and at the Space Life Sciences Laboratory (SLSL) at the Kennedy Space Center. The Integrated Smart Nanosensors for Space Biotechnology Applications component focused on developing and applying sensor technologies to space environments and agricultural systems. The research activities in nanosensors were coordinated with the SABRE portions of this grant and with the research sponsored by the NASA Environmental Systems Commercial Space Technology Center located in the Department of Environmental Engineering Sciences. Initial sensor efforts have focused on air and water quality monitoring essential to humans for living and working permanently in space, an important goal identified in NASA's strategic plan. The closed environment of a spacecraft or planetary base accentuates cause and effect relationships and environmental impacts. The limited available air and water resources emphasize the need for reuse, recycling, and system monitoring. It is essential to collect real-time information from these systems to ensure crew safety. This new class of nanosensors will be critical to monitoring the space flight environment in future NASA space systems. The Commercial Applications component of this program pursued industry partnerships to develop products for terrestrial use of NASA sponsored technologies, and in turn to stimulate growth in the biotechnology industry. For technologies demonstrating near term commercial potential, the objective is to include industry partners on or about the time of proof of concept that will not only co-invest in the technology but also take the resultant technology to the commercial market.

Novel Exercise Hardware Requirements, Development, and Selection Process for Long-Duration Space Flight

NASA Technical Reports Server (NTRS)

Weaver, Aaron S.; Funk, Justin H.; Funk, Nathan W.; Dewitt, John K.; Fincke, Renita S.; Newby, Nathaniel; Caldwell, Erin; Sheehan, Christopher C.; Moore, E. Cherice; Ploutz-Snyder, Lori;

Space Studies of the Earth-Moon System, Planets, and Small Bodies of the Solar System (B) Past, Present and Future of Small Body Science and Exploration (B0.4)

NASA Technical Reports Server (NTRS)

Abell, Paul; Mazanek, Dan; Reeves, Dan; Chodas, Paul; Gates, Michele; Johnson, Lindley; Ticker, Ronald

2016-01-01

To achieve its long-term goal of sending humans to Mars, the National Aeronautics and Space Administration (NASA) plans to proceed in a series of incrementally more complex human space flight missions. Today, human flight experience extends only to Low- Earth Orbit (LEO), and should problems arise during a mission, the crew can return to Earth in a matter of minutes to hours. The next logical step for human space flight is to gain flight experience in the vicinity of the Moon. These cis-lunar missions provide a "proving ground" for the testing of systems and operations while still accommodating an emergency return path to the Earth that would last only several days. Cis-lunar mission experience will be essential for more ambitious human missions beyond the Earth-Moon system, which will require weeks, months, or even years of transit time. In addition, NASA has been given a Grand Challenge to find all asteroid threats to human populations and know what to do about them. Obtaining knowledge of asteroid physical properties combined with performing technology demonstrations for planetary defense provide much needed information to address the issue of future asteroid impacts on Earth. Hence the combined objectives of human exploration and planetary defense give a rationale for the Asteroid Re-direct Mission (ARM).

Human and Robotic Space Mission Use Cases for High-Performance Spaceflight Computing

NASA Technical Reports Server (NTRS)

Some, Raphael; Doyle, Richard; Bergman, Larry; Whitaker, William; Powell, Wesley; Johnson, Michael; Goforth, Montgomery; Lowry, Michael

2013-01-01

Spaceflight computing is a key resource in NASA space missions and a core determining factor of spacecraft capability, with ripple effects throughout the spacecraft, end-to-end system, and mission. Onboard computing can be aptly viewed as a "technology multiplier" in that advances provide direct dramatic improvements in flight functions and capabilities across the NASA mission classes, and enable new flight capabilities and mission scenarios, increasing science and exploration return. Space-qualified computing technology, however, has not advanced significantly in well over ten years and the current state of the practice fails to meet the near- to mid-term needs of NASA missions. Recognizing this gap, the NASA Game Changing Development Program (GCDP), under the auspices of the NASA Space Technology Mission Directorate, commissioned a study on space-based computing needs, looking out 15-20 years. The study resulted in a recommendation to pursue high-performance spaceflight computing (HPSC) for next-generation missions, and a decision to partner with the Air Force Research Lab (AFRL) in this development.

National Space Biomedical Research Institute

NASA Technical Reports Server (NTRS)

2005-01-01

NSBRI partners with NASA to develop countermeasures against the deleterious effects of long duration space flight. NSBRI's science and technology projects are directed toward this goal, which is accomplished by: 1. Designing, testing and validating effective countermeasures to address the biological and environmental impediments to long-term human space flight. 2. Defining the molecular, cellular, organ-level, integrated responses and mechanistic relationships that ultimately determine these impediments, where such activity fosters the development of novel countermeasures. 3. Establishing biomedical support technologies to maximize human performance in space, reduce biomedical hazards to an acceptable level and deliver quality medical care. 4. Transferring and disseminating the biomedical advances in knowledge and technology acquired through living and working in space to the general benefit of humankind; including the treatment of patients suffering from gravity- and radiation-related conditions on Earth. and 5. ensuring open involvement of the scientific community,industry and the public in the Institute's activities and fostering a robust collaboration with NASA, particularly through JSC.

Gateway Architecture: A Major "Flexible Path" Step to the Moon and Mars After the International Space Station?

NASA Technical Reports Server (NTRS)

Thronson, Harley; Talay, Ted

2010-01-01

With NASA's commitment to the International Space Station (ISS) now all but certain for at least through the coming decade, serious consideration may be given to extended US in-space operations in the 2020s, when presumably the ISS will exceed its sell by date. Indeed, both ESA and Roscosmos, in addition to their unambiguous current commitment to ISS, have published early concept studies for extended post-ISS habitation (e.g., http://www.esa.int/esaHS/index.html, http://www.russianspaceweb.com/opsek.html and references therein). In the US, engineers and scientists have for a decade been working both within and outside NASA to assess one consistent candidate for long-term post-ISS habitation and operations, although interrupted by changing priorities for human space flight, Congressional direction, and constrained budgets. The evolving work of these groups is described here, which may have renewed relevance with the recent completion of a major review of the nation s human space flight program.

Pulmonary function in space

NASA Technical Reports Server (NTRS)

West, J. B.; Elliott, A. R.; Guy, H. J.; Prisk, G. K.

1997-01-01

The lung is exquisitely sensitive to gravity, and so it is of interest to know how its function is altered in the weightlessness of space. Studies on National Aeronautics and Space Administration (NASA) Spacelabs during the last 4 years have provided the first comprehensive data on the extensive changes in pulmonary function that occur in sustained microgravity. Measurements of pulmonary function were made on astronauts during space shuttle flights lasting 9 and 14 days and were compared with extensive ground-based measurements before and after the flights. Compared with preflight measurements, cardiac output increased by 18% during space flight, and stroke volume increased by 46%. Paradoxically, the increase in stroke volume occurred in the face of reductions in central venous pressure and circulating blood volume. Diffusing capacity increased by 28%, and the increase in the diffusing capacity of the alveolar membrane was unexpectedly large based on findings in normal gravity. The change in the alveolar membrane may reflect the effects of uniform filling of the pulmonary capillary bed. Distributions of blood flow and ventilation throughout the lung were more uniform in space, but some unevenness remained, indicating the importance of nongravitational factors. A surprising finding was that airway closing volume was approximately the same in microgravity and in normal gravity, emphasizing the importance of mechanical properties of the airways in determining whether they close. Residual volume was unexpectedly reduced by 18% in microgravity, possibly because of uniform alveolar expansion. The findings indicate that pulmonary function is greatly altered in microgravity, but none of the changes observed so far will apparently limit long-term space flight. In addition, the data help to clarify how gravity affects pulmonary function in the normal gravity environment on Earth.

From Process to Product: Your Risk Process at Work

NASA Technical Reports Server (NTRS)

Kundrot, Craig E.; Fogarty, Jenifer; Charles, John; Buquo, Lynn; Sibonga, Jean; Alexander, David; Horn, Wayne G.; Edwards, J. Michelle

2010-01-01

The Space Life Sciences Directorate (SLSD) and Human Research Program (HRP) at the NASA/Johnson Space Center work together to address and manage the human health and performance risks associated with human space flight. This includes all human system requirements before, during, and after space flight, providing for research, and managing the risk of adverse long-term health outcomes for the crew. We previously described the framework and processes developed for identifying and managing these human system risks. The focus of this panel is to demonstrate how the implementation of the framework and associated processes has provided guidance in the management and communication of human system risks. The risks of early onset osteoporosis, CO2 exposure, and intracranial hypertension in particular have all benefitted from the processes developed for human system risk management. Moreover, we are continuing to develop capabilities, particularly in the area of information architecture, which will also be described. We are working to create a system whereby all risks and associated actions can be tracked and related to one another electronically. Such a system will enhance the management and communication capabilities for the human system risks, thereby increasing the benefit to researchers and flight surgeons.

[Effect of space flight factors simulated in ground-based experiments on the behavior, discriminant learning, and exchange of monoamines in different brain structures of rats].

PubMed

Shtemberg, A S; Lebedeva-Georgievskaia, K V; Matveeva, M I; Kudrin, V S; Narkevich, V B; Klodt, P M; Bazian, A S

2014-01-01

Experimental treatment (long-term fractionated γ-irradiation, antiorthostatic hypodynamia, and the combination of these factors) simulating the effect of space flight in ground-based experiments rapidly restored the motor and orienting-investigative activity of animals (rats) in "open-field" tests. The study of the dynamics of discriminant learning of rats of experimental groups did not show significant differences from the control animals. It was found that the minor effect of these factors on the cognitive performance of animals correlated with slight changes in the concentration ofmonoamines in the brain structures responsible for the cognitive, emotional, and motivational functions.

Natural environment support guidelines for space shuttle tests and operations

NASA Technical Reports Server (NTRS)

Carter, E. A.; Brown, S. C.

1974-01-01

All space shuttle events from launch through solid rocket booster recovery and orbiter landing are considered in terms of constraints placed on those operations by the natural environment. Thunderstorm activity is discussed as an example of a possible hazard. The activities most likely to require advanced detection and monitoring techniques are identified as those from deorbit decision to Orbiter landing. The inflexible flight plan will require the transmission of real time wind profile information below 24 km and warnings of thunderstorms or turbulence in the Orbiter flight path. Extensive aerial reconnaissance and communication facilities and procedures to permit immediate transmission of aircraft reports to the mission control authority and to the Orbiter will also be required.

Development of the ECOSAR P-Band Synthetic Aperture Radar

NASA Technical Reports Server (NTRS)

Rincon, R. F.; Fatoyinbo, T.; Ranson, K. J.; Sun, G.; Deshpande, M.; Hale, R. D.; Bhat, A.; Perrine, M.; DuToit, C. F.; Bonds, Q.;

[Volume Homeostasis and Renal Function in Rats Exposed to Simulated and Actual Microgravity

NASA Technical Reports Server (NTRS)

Tucker, Bryan J.

1993-01-01

This project has investigated mechanisms that influence alterations in compartmental fluid and electrolyte balance in microgravity and evaluates countermeasures to control renal fluid and electrolyte losses. Determining the alterations due to space flight in fluid compartments and renal function is an important component in understanding long term adaptation to spaceflight and the contribution to post-flight orthostatic intolerance. Four definition phase studies and two studies examining neuro-humoral and vascular mechanisms have been completed.

Space Life-Support Engineering Program

NASA Technical Reports Server (NTRS)

Seagrave, Richard C. (Principal Investigator)

1995-01-01

This report covers the seventeen months of work performed under an extended one year NASA University Grant awarded to Iowa State University to perform research on topics relating to the development of closed-loop long-term life support systems with the initial principal focus on space water management. In the first phase of the program, investigators from chemistry and chemical engineering with demonstrated expertise in systems analysis, thermodynamics, analytical chemistry and instrumentation, performed research and development in two major related areas; the development of low-cost, accurate, and durable sensors for trace chemical and biological species, and the development of unsteady-state simulation packages for use in the development and optimization of control systems for life support systems. In the second year of the program, emphasis was redirected towards concentrating on the development of dynamic simulation techniques and software and on performing a thermodynamic systems analysis, centered on availability or energy analysis, in an effort to begin optimizing the systems needed for water purification. The third year of the program, the subject of this report, was devoted to the analysis of the water balance for the interaction between humans and the life support system during space flight and exercise, to analysis of the cardiopulmonary systems of humans during space flight, and to analysis of entropy production during operation of the air recovery system during space flight.

A Metadata Element Set for Project Documentation

NASA Technical Reports Server (NTRS)

Hodge, Gail; Templeton, Clay; Allen, Robert B.

2003-01-01

Abstract NASA Goddard Space Flight Center is a large engineering enterprise with many projects. We describe our efforts to develop standard metadata sets across project documentation which we term the "Goddard Core". We also address broader issues for project management metadata.

78 FR 48542 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-08

... Flight Requirements for Crew and Space Flight Participants AGENCY: Federal Aviation Administration (FAA...-0720. Title: Human Space Flight Requirements for Crew and Space Flight Participants. Form Numbers... information collection. Background: The FAA has established requirements for human space flight of crew and...

78 FR 29425 - Agency Information Collection Activities: Requests for Comments; Clearance of Renewed Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-20

... Flight Requirements for Crew and Space Flight Participants AGENCY: Federal Aviation Administration (FAA...-0720. Title: Human Space Flight Requirements for Crew and Space Flight Participants. Form Numbers... information collection. Background: The FAA has established requirements for human space flight of crew and...

Fiber lasers and amplifiers for science and exploration at NASA Goddard Space Flight Center

NASA Technical Reports Server (NTRS)

Krainak, Michael A.; Abshire, James; Allan, Graham R.; Stephen Mark

2005-01-01

We discuss present and near-term uses for high-power fiber lasers and amplifiers for NASA- specific applications including planetary topography and atmospheric spectroscopy. Fiber lasers and amplifiers offer numerous advantages for both near-term and future deployment of instruments on exploration and science remote sensing orbiting satellites. Ground-based and airborne systems provide an evolutionary path to space and a means for calibration and verification of space-borne systems. We present experimental progress on both the fiber transmitters and instrument prototypes for ongoing development efforts. These near-infrared instruments are laser sounders and lidars for measuring atmospheric carbon dioxide, oxygen, water vapor and methane and a pseudo-noise (PN) code laser ranging system. The associated fiber transmitters include high-power erbium, ytterbium, neodymium and Raman fiber amplifiers. In addition, we will discuss near-term fiber laser and amplifier requirements and programs for NASA free space optical communications, planetary topography and atmospheric spectroscopy.

Real-time monitoring of genetically modified Chlamydomonas reinhardtii during the Foton M3 space mission and ground irradiation experiment

NASA Astrophysics Data System (ADS)

Lambreva, Maya; Rea, Giuseppina; Antonacci, Amina; Serafini, Agnese; Damasso, Mario; Margonelli, Andrea; Johanningmeier, Udo; Bertalan, Ivo; Pezzotti, Gianni; Giardi, Maria Teresa

Long-term space exploration, colonization or habitation requires biological life support systems capable to cope with the deleterious space environment. The use of oxygenic photosynthetic microrganisms is an intriguing possibility mainly for food, O2 and nutraceutical compounds production. The critical points of utilizing plantsor algae-based life support systems are the microgravity and the ionizing radiation, which can influence the performance of these organisms. The aim of the present study was to assess the effects of space environment on the photosynthetic activity of various microrganisms and to select space stress-tolerant strains. Site-directed and random mutants of the unicellular green alga Chlamydomonas reinhardtii of Photosystem II D1 protein were used as a model system to test and select the amino acid substitutions capable to account for space stress tolerance. We focussed our studies also on the accumulation of the Photosystem II photoprotective carotenoids (the xantophylls violaxanthin, anteraxanthin and zeaxanthin), powerful antioxidants that epidemiological studies demonstrated to be human vision protectors. Metabolite profiling by quantitative HPLC methods revealed the organisms and the stress conditions capable to accumulate the highest pigment levels. In order to develop a project for a rationale metabolic engineering of algal secondary metabolites overproduction, we are performing expression analyses on the carotenoid biosynthetic pathway under physiological and mimicked space conditions. To identify the consequences of the space environment on the photosynthetic apparatus the changes in the Photosystem II efficiency were monitored in real time during the ESA-Russian Foton-M3 mission in September 2007. For the space flight a high-tech, multicell fluorescence biosensor, Photo-II, was designed and built by the Centre for Advanced Research in Space Optics in collaboration with Kayser-Italy, Biosensor and DAS. Photo-II is an automatic device developed to measure the chlorophyll fluorescence and to provide a living conditions for 24 different algae strains. Twelve different C. reinhardtii strains were analytically selected and two replications for each strain were brought to space, among them, some mutants modified at the level of enzymes involved in the biosynthesis of xanthophylls. We analysed the hourly changes and the daily light/dark trend in the maximum quantum yield of PSII photochemistry as well as some physiological parameters that characterize the post-flight effect on algae viability and photosynthetic performance. The ground control experiments were performed following the same protocol for the sample preparation and the temperature recorded during the pre-flight, flight and post-flight phases. The space flight results in comparison to the ground simulations are discussed.

The Human in Space: Lesson from ISS

NASA Technical Reports Server (NTRS)

Sams, Clarence F.

2009-01-01

This viewgraph presentation reviews the lessons learned from manned space flight on the International Space Station. The contents include: 1) Overview of space flight effects on crewmembers; 2) General overview of immune system; 3) How does space flight alter immune system? 4) What factors associated with space flight inteact with crewmember immune function and impact health risks? 5) What is the current understanding of space flight effects on the immune system? and 6) Why should NASA be interested in immunology? Why is it significant?

Study of values and interpersonal perception in cosmonauts on board of international space station

NASA Astrophysics Data System (ADS)

Vinokhodova, A. G.; Gushin, V. I.

2014-01-01

The increased heterogeneity of International Space Station (ISS) crews' composition (in terms of nationality, profession and gender) together with stressful situations, due to space flight, can have a significant impact on group interaction and cohesion, as well as on communications with Mission Control Center (MCC) and the success of the mission as a whole. Culturally related differences in values, goals, and behavioral norms could influence mutual perception and, thus, cohesive group formation. The purpose of onboard "Interaction-Attitudes" experiment is to study the patterns of small group (space crew) behavior in extended space flight. Onboard studies were performed in the course of ISS Missions 19-30 with participation of twelve Russian crewmembers. Experimental schedule included 3 phases: preflight training and Baseline Data Collection; inflight activities once in two weeks; post-flight measurement. We used Personal Self-Perception and Attitudes (PSPA) software for analyzing subjects' attitudes toward social environment (crewmembers and MCC). It is based on the semantic differential and the repertory grid technique. To study the content of interpersonal perception we used content-analysis with participation of the experts, independently attributing each construct to the 17 semantic categories, which were described in our previous study. The data obtained demonstrated that the system of values and personal attitudes in the majority of participated cosmonauts remained mostly stable under stress-factors of extended space flight. Content-analysis of the important criteria elaborated by the subjects for evaluation of their social environment, showed that the most valuable personal traits for cosmonauts were those that provided the successful fulfillment of professional activity (motivation, intellectual level, knowledge, and self-discipline) and good social relationships (sociability, friendship, and tolerance), as well. Post-flight study of changes in perceptions, related to Real Self-image, did not reveal significant differences between the images of Russian crew-members and representatives from foreign space agencies. A certain difference in perceptions was found in cosmonauts with more integrated system of evaluations: after space flight they perceived foreign participants as "closer" to their Ideal, while Russian crew-members were perceived mostly as "distant" from Ideal Self of these subjects. Perceptions of people from Earth were also more critical. These differences are likely to be manifestations of interpersonal perception stereotypes. Described patterns of changes in perceptions of cosmonauts, who have performed space flight as a part of ISS multinational crew, allow us to suggest the recommendations for development of ISS crew training, in particular, it seems useful to increase the time of joint training for deepening of intercultural interaction.

Nutrition in space

NASA Technical Reports Server (NTRS)

Smith, S. M.; Davis-Street, J.; Rice, B. L.; Lane, H. W.

1997-01-01

The authors review studies conducted to define nutritional requirements for astronauts during space flight and to assess nutrition before, during, and after space flight. Topics include space food systems, research and limitations on spacecraft, physiological adaptation to weightlessness, energy requirements, dietary intake during space flight, bone demineralization, gastrointestinal function, blood volume, and nutrition requirements for space flight. Benefits of space-related nutrition research are highlighted.

Results of space environment measurement carried out by the Roscosmos monitoring system elements and their correlation with different space weather characteristics

NASA Astrophysics Data System (ADS)

Protopopov, Grigory; Anashin, Vasily; Elushov, Ilya; Kozyukova, Olga

The Monitoring System of space radiation exposure on electronic components is developed by the Institute of Space Device Engineering by order Roscosmos. The key targets of the Monitoring System are space environment measurements, space model correction, space weather characteristics forecast, improvement of radiation hardness technical requirements and etc. The Monitoring System includes two parts: the ground-based and the space-born segments. The ground-based segment includes the forecast station, the analytic complex and the data output system. The space-born segment base elements are TID sensors operating by MNOSFET dosimetry principle. Sensor temperature stabilization is achieved by choosing of operational point according to the minimal change of sensor current-voltage curve. The set of 38 TID sensors is placed on 19 spacecrafts currently. The spacecrafts operate in Medium Earth Orbit (MEO) (approximately 20 000 km with inclination of 65(°) ). The flight data obtained perfectly correlate with total dose flight data registered using MOSFET placed on Van Allen Probe spacecraft functioning in high elliptical orbit (apogee is 37 000 km, perigee is 650 km, inclination is 10(°) ). Also coincidence with the dose data from GIOVE-B spacecraft (circular orbit 23200 km, inclination of 56(°) ) of Galileo system is observed. We have observed several abrupt dose rate increases from April, 2010. The flight data are compared with other monitoring system data and ground measurements. The comparison results show that high energy electrons (> 1 MeV) give general contribution in accumulated dose and anomalous dose rate increases. These results are in agreement with shielding stopping power calculation results. The high electron fluxes rise significantly in MEO as a result of Van Allen belts shifting during geomagnetic storms. The flight data were compared with calculation results obtained using different space models. The comparison shows that for some long-term interval the distinction between experimental and calculated results can be 7 times less or more.

Trapped Radiation Model Uncertainties: Model-Data and Model-Model Comparisons

NASA Technical Reports Server (NTRS)

Armstrong, T. W.; Colborn, B. L.

2000-01-01

The standard AP8 and AE8 models for predicting trapped proton and electron environments have been compared with several sets of flight data to evaluate model uncertainties. Model comparisons are made with flux and dose measurements made on various U.S. low-Earth orbit satellites (APEX, CRRES, DMSP, LDEF, NOAA) and Space Shuttle flights, on Russian satellites (Photon-8, Cosmos-1887, Cosmos-2044), and on the Russian Mir Space Station. This report gives the details of the model-data comparisons-summary results in terms of empirical model uncertainty factors that can be applied for spacecraft design applications are given in a combination report. The results of model-model comparisons are also presented from standard AP8 and AE8 model predictions compared with the European Space Agency versions of AP8 and AE8 and with Russian-trapped radiation models.

Trapped Radiation Model Uncertainties: Model-Data and Model-Model Comparisons

NASA Technical Reports Server (NTRS)

Armstrong, T. W.; Colborn, B. L.

2000-01-01

The standard AP8 and AE8 models for predicting trapped proton and electron environments have been compared with several sets of flight data to evaluate model uncertainties. Model comparisons are made with flux and dose measurements made on various U.S. low-Earth orbit satellites (APEX, CRRES, DMSP. LDEF, NOAA) and Space Shuttle flights, on Russian satellites (Photon-8, Cosmos-1887, Cosmos-2044), and on the Russian Mir space station. This report gives the details of the model-data comparisons -- summary results in terms of empirical model uncertainty factors that can be applied for spacecraft design applications are given in a companion report. The results of model-model comparisons are also presented from standard AP8 and AE8 model predictions compared with the European Space Agency versions of AP8 and AE8 and with Russian trapped radiation models.

Antarctic Space Analog Program

NASA Technical Reports Server (NTRS)

Palinkas, Lawrence A; Gunderson, E. K. Eric; Johnson, Jeffrey C.; Holland, Albert W.

1998-01-01

The primary aim of this project was to examine group dynamics and individual performance in extreme, isolated environments and identify human factors requirements for long-duration space missions using data collected in an analog environment. Specifically, we wished to determine: 1) the characteristics of social relations in small groups of individuals living and working together in extreme, isolated environments, and 2) the environmental, social and psychological determinants of performance effectiveness in such groups. These two issues were examined in six interrelated studies using data collected in small, isolated research stations in Antarctica from 1963 to the present. Results from these six studies indicated that behavior and performance on long-duration space flights is likely to be seasonal or cyclical, situational, social, and salutogenic in nature. The project responded to two NASA program emphases for FY 1997 as described in the NRA: 1) the primary emphasis of the Behavior and Performance Program on determining long-term individual and group performance responses to space, identifying critical factors affecting those responses and understanding underlying mechanisms involved in behavior and performance, and developing and using ground-based models and analogs for studying space-related behavior and performance; and 2) the emphasis of the Data Analysis Program on extended data analysis. Results from the study were used to develop recommendations for the design and development of pre-flight crew training and in-flight psychological countermeasures for long-duration manned space missions.

Space shuttle plume/simulation application: Results and math model supersonic data

NASA Technical Reports Server (NTRS)

Boyle, W.; Conine, B.; Bell, G.

1979-01-01

The analysis of pressure and gage wind tunnel data from space shuttle wind tunnel test IA138 was performed to define the aerodynamic influence of the main propulsion system and solid rocket booster plumes on the total vehicles, elements, and components of the space shuttle vehicle during the supersonic portion of ascent flight. A math model of the plume induced aerodynamic characteristics was developed for a range of Mach numbers to match the forebody aerodynamic math model. The base aerodynamic characteristics are presented in terms of forces and moments versus attitude. Total vehicle base and forebody aerodynamic characteristics are presented in terms of aerodynamic coefficients for Mach numbers from 1.55 to 2.5.

Meteorological regimes for the classification of aerospace air quality predictions for NASA-Kennedy Space Center

NASA Technical Reports Server (NTRS)

Stephens, J. B.; Sloan, J. C.

1976-01-01

A method is described for developing a statistical air quality assessment for the launch of an aerospace vehicle from the Kennedy Space Center in terms of existing climatological data sets. The procedure can be refined as developing meteorological conditions are identified for use with the NASA-Marshall Space Flight Center Rocket Exhaust Effluent Diffusion (REED) description. Classical climatological regimes for the long range analysis can be narrowed as the synoptic and mesoscale structure is identified. Only broad synoptic regimes are identified at this stage of analysis. As the statistical data matrix is developed, synoptic regimes will be refined in terms of the resulting eigenvectors as applicable to aerospace air quality predictions.

Physics of Colloids in Space (PCS) Flight Hardware Developed

NASA Technical Reports Server (NTRS)

Koudelka, John M.

2001-01-01

investigation that will be located in an Expedite the Process of Experiments to Space Station (EXPRESS) Rack. The investigation will be conducted in the International Space Station U.S. laboratory, Destiny, over a period of approximately 10 months during the station assembly period from flight 6A through flight UF-2. This experiment will gather data on the basic physical properties of colloids by studying three different colloid systems with the objective of understanding how they grow and what structures they form. A colloidal suspension consists of fine particles (micrometer to submicrometer) suspended in a fluid for example, paints, milk, salad dressings, and aerosols. The long-term goal of this investigation is to learn how to steer the growth of colloidal suspensions to create new materials and new structures. This experiment is part of a two-stage investigation conceived by Professor David Weitz of Harvard University along with Professor Peter Pusey of the University of Edinburgh. The experiment hardware was developed by the NASA Glenn Research Center through contracts with Dynacs, Inc., and ZIN Technologies.

Contamination Examples and Lessons from Low Earth Orbit Experiments and Operational Hardware

NASA Technical Reports Server (NTRS)

Pippin, Gary; Finckenor, Miria M.

2009-01-01

Flight experiments flown on the Space Shuttle, the International Space Station, Mir, Skylab, and free flyers such as the Long Duration Exposure Facility, the European Retrievable Carrier, and the EFFU, provide multiple opportunities for the investigation of molecular contamination effects. Retrieved hardware from the Solar Maximum Mission satellite, Mir, and the Hubble Space Telescope has also provided the means gaining insight into contamination processes. Images from the above mentioned hardware show contamination effects due to materials processing, hardware storage, pre-flight cleaning, as well as on-orbit events such as outgassing, mechanical failure of hardware in close proximity, impacts from man-made debris, and changes due to natural environment factors.. Contamination effects include significant changes to thermal and electrical properties of thermal control surfaces, optics, and power systems. Data from several flights has been used to develop a rudimentary estimate of asymptotic values for absorptance changes due to long-term solar exposure (4000-6000 Equivalent Sun Hours) of silicone-based molecular contamination deposits of varying thickness. Recommendations and suggestions for processing changes and constraints based on the on-orbit observed results will be presented.

Strongly Interacting Fermi Gases in Two Dimensions

DTIC Science & Technology

2012-07-17

other in k- space owing to the spin- orbit interaction. For a finite field B (Z) z , a gap opens in the spectrum. This gap, known as the spin-orbit...from the trap. Time-of-flight maps momentum to real space , allowing direct momentum resolution of the spin popula- tions. As a function of pulse...at a given quasi-momentum q, can be expanded in terms of free space eigenstates as 5 FIG. 3. Creating and probing a spin-orbit coupled lattice. (A

Role of Corticosteroids in Bone Loss During Space Flight

NASA Technical Reports Server (NTRS)

Wronski, Thomas J.; Halloran, Bernard P.; Miller, Scott C.

1998-01-01

The primary objective of this research project is to test the hypothesis that corticosteroids contribute to the adverse skeletal effects of space flight. To achieve this objective, serum corticosteroids, which are known to increase during space flight, must be maintained at normal physiologic levels in flight rats by a combination of adrenalectomy and corticosteroid supplementation via implanted hormone pellets. Bone analyses in these animals will then be compared to those of intact flight rats that, based on past experience, will undergo corticosteroid excess and bone loss during space flight. The results will reveal whether maintaining serum corticosteroids at physiologic levels in flight rats affects the skeletal abnormalities that normally develop during space flight. A positive response to this question would indicate that the bone loss and decreased bone formation associated with space flight are mediated, at least in part, by corticosteroid excess.

Subsonic Longitudinal Performance Coefficient Extraction from Shuttle Flight Data: an Accuracy Assessment for Determination of Data Base Updates

NASA Technical Reports Server (NTRS)

Findlay, J. T.; Kelly, G. M.; Mcconnell, J. G.; Compton, H. R.

1983-01-01

Longitudinal performance comparisons between flight derived and predicted values are presented for the first five NASA Space Shuttle Columbia flights. Though subsonic comparisons are emphasized, comparisons during the transonic and low supersonic regions of flight are included. Computed air data information based on the remotely sensed atmospheric measurements as well as in situ Orbiter Air Data System (ADS) measurements were incorporated. Each air data source provides for comparisons versus the predicted values from the LaRC data base. Principally, L/D, C sub L, and C sub D, comparisons are presented, though some pitching moment results are included. Similarities in flight conditions and spacecraft configuration during the first five flights are discussed. Contributions from the various elements of the data base are presented and the overall differences observed between the flight and predicted values are discussed in terms of expected variations. A discussion on potential data base updates is presented based on the results from the five flights to date.

Physiological spacecraft environment data documentation

NASA Technical Reports Server (NTRS)

1977-01-01

The physiological limits of exposure to environmental parameters encountered during space flight was documented. The environmental limits which have been previously established were described in terms of acceptable physiological changes. The process of coordinating data and assembling the completed data book is described in this report.

An Exploratory Study of Runway Arrival Procedures: Time Based Arrival and Self-Spacing

NASA Technical Reports Server (NTRS)

Houston, Vincent E.; Barmore, Bryan

2009-01-01

The ability of a flight crew to deliver their aircraft to its arrival runway on time is important to the overall efficiency of the National Airspace System (NAS). Over the past several years, the NAS has been stressed almost to its limits resulting in problems such as airport congestion, flight delay, and flight cancellation to reach levels that have never been seen before in the NAS. It is predicted that this situation will worsen by the year 2025, due to an anticipated increase in air traffic operations to one-and-a-half to three times its current level. Improved arrival efficiency, in terms of both capacity and environmental impact, is an important part of improving NAS operations. One way to improve the arrival performance of an aircraft is to enable the flight crew to precisely deliver their aircraft to a specified point at either a specified time or specified interval relative to another aircraft. This gives the flight crew more control to make the necessary adjustments to their aircraft s performance with less tactical control from the controller; it may also decrease the controller s workload. Two approaches to precise time navigation have been proposed: Time-Based Arrivals (e.g., required times of arrival) and Self-Spacing. Time-Based Arrivals make use of an aircraft s Flight Management System (FMS) to deliver the aircraft to the runway threshold at a given time. Self-Spacing enables the flight crew to achieve an ATC assigned spacing goals at the runway threshold relative to another aircraft. The Joint Planning and Development Office (JPDO), a multi-agency initiative established to plan and coordinate the development of the Next Generation Air Transportation System (NextGen), has asked for data for both of these concepts to facilitate future research and development. This paper provides a first look at the delivery performance of these two concepts under various initial and environmental conditions in an air traffic simulation environment.

14 CFR 437.27 - Pre-flight and post-flight operations.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Pre-flight and post-flight operations. 437.27 Section 437.27 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION... Experimental Permit Operational Safety Documentation § 437.27 Pre-flight and post-flight operations. An...

14 CFR 437.27 - Pre-flight and post-flight operations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Pre-flight and post-flight operations. 437.27 Section 437.27 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION... Experimental Permit Operational Safety Documentation § 437.27 Pre-flight and post-flight operations. An...

14 CFR 437.27 - Pre-flight and post-flight operations.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Pre-flight and post-flight operations. 437.27 Section 437.27 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION... Experimental Permit Operational Safety Documentation § 437.27 Pre-flight and post-flight operations. An...

14 CFR 437.27 - Pre-flight and post-flight operations.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Pre-flight and post-flight operations. 437.27 Section 437.27 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION... Experimental Permit Operational Safety Documentation § 437.27 Pre-flight and post-flight operations. An...

14 CFR 1214.115 - Standard services.

Code of Federal Regulations, 2010 CFR

2010-01-01

....115 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT General Provisions Regarding Space Shuttle Flights of Payloads for Non-U.S. Government, Reimbursable Customers § 1214.... (d) A five-person flight crew: commander, pilot and three mission specialists. (e) Orbiter flight...

14 CFR 1214.115 - Standard services.

Code of Federal Regulations, 2013 CFR

2013-01-01

....115 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT General Provisions Regarding Space Shuttle Flights of Payloads for Non-U.S. Government, Reimbursable Customers § 1214.... (d) A five-person flight crew: commander, pilot and three mission specialists. (e) Orbiter flight...

14 CFR 1214.115 - Standard services.

Code of Federal Regulations, 2012 CFR

2012-01-01

....115 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT General Provisions Regarding Space Shuttle Flights of Payloads for Non-U.S. Government, Reimbursable Customers § 1214.... (d) A five-person flight crew: commander, pilot and three mission specialists. (e) Orbiter flight...

Use of phytochrome-dependent reaction in evaluating the effect of space flight factors on the plant organism

NASA Technical Reports Server (NTRS)

Shteyne, B. A.; Nevzgodina, L. V.; Miller, A. T.

1982-01-01

The effects of space flight factors on lettuce seeds aboard the Kosmos-936 and Kosmos-1129 satellites for 20 days were studied. The phytochrome dependent (PD) reaction of light sensitive seeds was a sensitive criterion for evaluating the biological effects of space flight factors. The PD reaction of air dry lettuce seeds was suppressed after space flight, especially if the seeds were exposed to open space during the flight. Space flight affects the physiological activity of both phytochrome forms, and both the phi sub 730 dependent reactions of lettuce seeds were suppressed.

Research opportunities in human behavior and performance

NASA Technical Reports Server (NTRS)

Christensen, J. M. (Editor); Talbot, J. M. (Editor)

1985-01-01

Extant information on the subject of psychological aspects of manned space flight are reviewed; NASA's psychology research program is examined; significant gaps in knowledge are identified; and suggestions are offered for future research program planning. Issues of human behavior and performance related to the United States space station, to the space shuttle program, and to both near and long term problems of a generic nature in applicable disciplines of psychology are considered. Topics covered include: (1) human performance requirements for a 90 day mission; (2) human perceptual, cognitive, and motor capabilities and limitations in space; (3) crew composition, individual competencies, crew competencies, selection criteria, and special training; (4) environmental factors influencing behavior; (5) psychosocial aspects of multiperson space crews in long term missions; (6) career determinants in NASA; (7) investigational methodology and equipment; and (8) psychological support.

CONCORD: comparison of cosmic radiation detectors in the radiation field at aviation altitudes

NASA Astrophysics Data System (ADS)

Meier, Matthias M.; Trompier, François; Ambrozova, Iva; Kubancak, Jan; Matthiä, Daniel; Ploc, Ondrej; Santen, Nicole; Wirtz, Michael

2016-05-01

Space weather can strongly affect the complex radiation field at aviation altitudes. The assessment of the corresponding radiation exposure of aircrew and passengers has been a challenging task as well as a legal obligation in the European Union for many years. The response of several radiation measuring instruments operated by different European research groups during joint measuring flights was investigated in the framework of the CONCORD (COmparisoN of COsmic Radiation Detectors) campaign in the radiation field at aviation altitudes. This cooperation offered the opportunity to measure under the same space weather conditions and contributed to an independent quality control among the participating groups. The CONCORD flight campaign was performed with the twin-jet research aircraft Dassault Falcon 20E operated by the flight facility Oberpfaffenhofen of the German Aerospace Center (Deutsches Zentrum für Luft- und Raumfahrt, DLR). Dose rates were measured at four positions in the atmosphere in European airspace for about one hour at each position in order to obtain acceptable counting statistics. The analysis of the space weather situation during the measuring flights demonstrates that short-term solar activity did not affect the results which show a very good agreement between the readings of the instruments of the different institutes.

A One Chip Hardened Solution for High Speed SpaceWire System Implementations. Session: Components

NASA Technical Reports Server (NTRS)

Marshall, Joseph R.; Berger, Richard W.; Rakow, Glenn P.

2007-01-01

An Application Specific Integrated Circuit (ASIC) that implements the SpaceWire protocol has been developed in a radiation hardened 0.25 micron CMOS technology. This effort began in March 2003 as a joint development between the NASA Goddard Space Flight Center (GSFC) and BAE Systems. The BAE Systems SpaceWire ASIC is comprised entirely of reusable core elements, many of which are already flight-proven. It incorporates a router with 4 SpaceWire ports and two local ports, dual PC1 bus interfaces, a microcontroller, 32KB of internal memory, and a memory controller for additional external memory use. The SpaceWire cores are also reused in other ASICs under development. The SpaceWire ASIC is planned for use on the Geostationary Operational Environmental Satellites (GOES)-R, the Lunar Reconnaissance Orbiter (LRO) and other missions. Engineering and flight parts have been delivered to programs and users. This paper reviews the SpaceWire protocol and those elements of it that have been built into the current and next SpaceWire reusable cores and features within the core that go beyond the current standard and can be enabled or disabled by the user. The adaptation of SpaceWire to BAE Systems' On Chip Bus (OCB) for compatibility with the other reusable cores will be reviewed and highlighted. Optional configurations within user systems and test boards will be shown. The physical implementation of the design will be described and test results from the hardware will be discussed. Application of this ASIC and other ASICs containing the SpaceWire cores and embedded microcontroller to Plug and Play and reconfigurable implementations will be described. Finally, the BAE Systems roadmap for SpaceWire developments will be updated, including some products already in design as well as longer term plans.

The National Aerospace Initiative (NAI): Technologies For Responsive Space Access

NASA Technical Reports Server (NTRS)

Culbertson, Andrew; Bhat, Biliyar N.

2003-01-01

The Secretary of Defense has set new goals for the Department of Defense (DOD) to transform our nation's military forces. The Director for Defense Research and Engineering (DDR&E) has responded to this challenge by defining and sponsoring a transformational initiative in Science and Technology (S&T) - the National Aerospace Initiative (NAI) - which will have a fundamental impact on our nation's military capabilities and on the aerospace industry in general. The NAI is planned as a joint effort among the tri-services, DOD agencies and National Aeronautics and Space Administration (NASA). It is comprised of three major focus areas or pillars: 1) High Speed Hypersonics (HSH), 2) Space Access (SA), and 3) Space Technology (ST). This paper addresses the Space Access pillar. The NAI-SA team has employed a unique approach to identifying critical technologies and demonstrations for satisfying both military and civilian space access capabilities needed in the future. For planning and implementation purposes the NAI-SA is divided into five technology subsystem areas: Airframe, Propulsion, Flight Subsystems, Operations and Payloads. Detailed technology roadmaps were developed under each subsystem area using a time-phased, goal oriented approach that provides critical space access capabilities in a timely manner and involves subsystem ground and flight demonstrations. This S&T plan addresses near-term (2009), mid-term (2016), and long-term (2025) goals and objectives for space access. In addition, system engineering and integration approach was used to make sure that the plan addresses the requirements of the end users. This paper describes in some detail the technologies in NAI-Space Access pillar. Some areas of emphasis are: high temperature materials, thermal protection systems, long life, lightweight, highly efficient airframes, metallic and composite cryotanks, advanced liquid rocket engines, integrated vehicle health monitoring and management, highly operable systems and payloads. Implementation strategies for NAI are also described.

Advanced biosensors for monitoring astronauts' health during long-duration space missions.

PubMed

Roda, Aldo; Mirasoli, Mara; Guardigli, Massimo; Zangheri, Martina; Caliceti, Cristiana; Calabria, Donato; Simoni, Patrizia

2018-07-15

Long-duration space missions pose important health concerns for astronauts, especially regarding the adverse effects of microgravity and exposure to high-energy cosmic rays. The long-term maintenance of crew health and performance mainly relies on prevention, early diagnoses, condition management, and medical interventions in situ. In-flight biosensor diagnostic devices and medical procedures must use few resources and operate in a microgravity environment, which complicates the collection and management of biological samples. Moreover, the biosensors must be certified for in-flight operation according to strict design and safety regulations. Herein, we report on the state of the art and recent advances in biosensing diagnostic instrumentation for monitoring astronauts' health during long-duration space missions, including portable and wearable biosensors. We discuss perspectives on new-format biosensors in autonomous space clinics. We also describe our own work in developing biosensing devices for non-invasively diagnosing space-related diseases, and how they are used in long-duration missions. Finally, we discuss the benefits of space exploration for Earth-based medicine. Copyright © 2018 Elsevier B.V. All rights reserved.

Modeling and analysis of selected space station communications and tracking subsystems

NASA Technical Reports Server (NTRS)

Richmond, Elmer Raydean

1993-01-01

The Communications and Tracking System on board Space Station Freedom (SSF) provides space-to-ground, space-to-space, audio, and video communications, as well as tracking data reception and processing services. Each major category of service is provided by a communications subsystem which is controlled and monitored by software. Among these subsystems, the Assembly/Contingency Subsystem (ACS) and the Space-to-Ground Subsystem (SGS) provide communications with the ground via the Tracking and Data Relay Satellite (TDRS) System. The ACS is effectively SSF's command link, while the SGS is primarily intended as the data link for SSF payloads. The research activities of this project focused on the ACS and SGS antenna management algorithms identified in the Flight System Software Requirements (FSSR) documentation, including: (1) software modeling and evaluation of antenna management (positioning) algorithms; and (2) analysis and investigation of selected variables and parameters of these antenna management algorithms i.e., descriptions and definitions of ranges, scopes, and dimensions. In a related activity, to assist those responsible for monitoring the development of this flight system software, a brief summary of software metrics concepts, terms, measures, and uses was prepared.

Crew quarters for Space Station

NASA Technical Reports Server (NTRS)

Mount, F. E.

1989-01-01

The only long-term U.S. manned space mission completed has been Skylab, which has similarities as well as differences to the proposed Space Station. With the exception of Skylab missions, there has been a dearth of experience on which to base the design of the individual Space Station Freedom crew quarters. Shuttle missions commonly do not have sleep compartments, only 'sleeping arrangements'. There are provisions made for each crewmember to have a sleep restraint and a sleep liner, which are attached to a bulkhead or a locker. When the Shuttle flights began to have more than one working shift, crew quarters became necessary due to noise and other disturbances caused by crew task-related activities. Shuttle missions that have planned work shifts have incorporated sleep compartments. To assist in gaining more information and insight for the design of the crew quarters for the Space Station Freedom, a survey was given to current crewmembers with flight experience. The results from this survey were compiled and integrated with information from the literature covering space experience, privacy, and human-factors issues.

Investigations of perspective technologies, equipment and sanitary - hygienic means for Life-Support System of new generation

NASA Astrophysics Data System (ADS)

Shumilina, I. V.

Creation of optimal sanitary - hygienic conditions allows to keep health and capacity of the crewmembers work at increase of space flight duration. There is a wide application experience of means, methods and equipment for sanitary - hygienic supply, which were developed and experimentally tested for space flights. However, about 800 kg personal hygiene means (napkins and towels are made with water and delivered with the Earth) are necessary for 3 crewmembers per one year. For long orbital and interplanetary flights (without an opportunity of stocks updating) it is necessary to increase a degree of Life-Support System isolation and optimization of goods turnover. Washing combined with water regeneration system is most perspective for sanitary - hygienic procedures. Therefore, creation of space equipment for washing with sanitary - hygienic water (SHW) regeneration system is especially important. The researches have shown, that to processes, which can be applied for SHW regeneration in space conditions and require insignificant quantity of additional materials (as against sorption), concern membrane methods (reverse osmosis, nanofiltration etc.). Two-step membrane unit for SHW regeneration recovered no less than 85 % of permeate with the organic and inorganic selectivity of 82-95 %. The tests of two-step membrane unit for SHW regeneration carried out on mock up solutions and real SHW, containing detergents really used in space flight conditions. The researches on a substantiation of an opportunity of clothing washing, clothing drying and the estimation of an opportunity of application of various detergents for clothing washing are urgent. The tests of water extraction technology from textile materials are carried out. Is established, that at conditional time of contact 1s, humidity of a leaving air flow from clothing drying unit comes nearer to 100 %. It is necessary to solve the problem for creation of Life-Support System of new generation for long-term space flight conditions in view of an opportunity of integration of technologies, equipment and sanitary - hygienic supply means.

Detection and Prevention of Cardiac Arrhythmias During Space Flight

NASA Technical Reports Server (NTRS)

Pillai, Dilip; Rosenbaum, David S.; Liszka, Kathy J.; York, David W.; Mackin, Michael A.; Lichter, Michael J.

2004-01-01

There have been reports suggesting that long-duration space flight might lead to an increased risk of potentially serious heart rhythm disturbances. If space flight does, in fact, significantly decrease cardiac electrical stability, the effects could be catastrophic, potentially leading to sudden cardiac death. It will be important to determine the mechanisms underlying this phenomenon in order to prepare for long-term manned lunar and interplanetary missions and to develop appropriate countermeasures. Our hypothesis is that prolonged exposure to microgravity will alter T wave alternans measurements, decrease heart rate variance, increase QT dispersion, decrease heart rate recovery and alter QT restitution curve. A recently published study has shown that long duration spaceflights prolong cardiac conduction and repolarization. They concluded that long duration flight is associated with QT interval prolongation and may increase arrhythmia susceptibility. We propose using computer technology as a noninvasive clinical tool to detect and study clinically significant TWA during standard exercise testing using electrode systems specifically adapted for the purpose of obtaining and measuring TWA. A population of approximately 15 healthy men and 5 healthy women subjects, representative of the astronaut cohort will be asked to voluntarily participate in this study. Their blood pressure and ECG/TWA will be measured pre-flight and in-flight. Prior to flight, subjects will be asked to participate in an orientation session. Still photos will be taken of the skin where the conductive gel is used for the multi-segment sensors. Photos will be recorded preflight, immediately postflight, and several times during the proceeding week until it has been determined that any skin reaction has disappeared or that no rash is present and will not appear.

Columbia: The first 5 flights entry heating data series. Volume 5: The side fuselage and payload bay door

NASA Technical Reports Server (NTRS)

Williams, S. D.

1984-01-01

Entry heating flight data and wind tunnel data on the side fuselage and payload bay door, Z = 400 and 440 trace aft of X/L=0.2, for the first five flights of the Space Shuttle Orbiter are presented. The heating rate data are reviewed in terms of normalized film heat transfer coefficients as a function of angle of attack, Mach number, and normal shock Reynolds number. The surface heatings rates and temperatures were obtained by the JSC NONLIN/INVERSE computer program. Time history plots of the surface heating rates and temperatures are outlined.

Experiment requirements: Vitamin D metabolites and bone demineralization, Spacelab 2, experiment no. 1

NASA Technical Reports Server (NTRS)

Schnoes, H. K.; Holton, E. M.; Thirolf, R. G.

1978-01-01

As a contribution toward an understanding of the molecular basis of bone loss, mineral imbalance, and increasing fecal calcium under conditions of prolonged space flight, the blood levels of biologically active vitamin D metabolites of flight crew members will be quantitatively measured. Prior to the mission, the refinement of existing and the development of new techniques for the assay of all vitamin D metabolites will provide an arsenal of methods suitable for a wide range of metabolite levels. In terms of practical application, the analysis of human and animal plasma samples, Spacelab crew plasma samples, and flight hardware are envisioned.

Columbia undergoes final shakedown during seven-day STS-4 mission

NASA Technical Reports Server (NTRS)

1982-01-01

The launch preparations for the Space Transportation System 4 flight of the space shuttle Columbia are described. The details of the spacecraft's mission profile are given. Several experiments and payloads are described. An account of the remote manipulator system is given. Studies of long-term thermal extremes on the orbiter subsystems and a survey of orbiter induced contamination of the payload bay are identified as mission priorities.

Expedition 4 Crew Interviews: Carl Walz

NASA Technical Reports Server (NTRS)

2001-01-01

Expedition 4 Flight Engineer Carl Walz is seen during a prelaunch interview. He gives details on the mission's goals and significance, his role in the mission, what his responsibilities will be, what the crew exchange will be like (transferring the Expedition 4 crew in place of the Expedition 3 crew on the International Space Station (ISS)), the day-to-day life on an extended stay mission, the experiments he will be conducting on board, and what the S0 truss will mean to ISS. Walz ends with his thoughts on the short-term and long-term future of the International Space Station.

Expedition 4 Crew Interviews: Dan Bursch

NASA Technical Reports Server (NTRS)

2001-01-01

Expedition 4 Flight Engineer Dan Bursch is seen during a prelaunch interview. He gives details on the mission's goals and significance, his role in the mission, what his responsibilities will be, what the crew exchange will be like (transferring the Expedition 4 crew in place of the Expedition 3 crew on the International Space Station (ISS)), the day-to-day life on an extended stay mission, the experiments he will be conducting on board, and what the S0 truss will mean to ISS. Bursch ends with his thoughts on the short-term and long-term future of the International Space Station.

Modeled Microgravity Inhibits Apoptosis in Peripheral Blood Lymphocytes

NASA Technical Reports Server (NTRS)

Risin, Diana; Pellis, Neal R.

1999-01-01

Impairment of the immunity in astronauts and cosmonauts even in short term flights is a recognized risk. Long term orbital space missions and anticipated interplanetary flights increase the concern for more pronounced effects on the immune system with potential clinical consequences. Impairment of the immunity in space may be due tonumerous physiological changes caused by space-related factors, which in turn affect the immune system, or alternatively, it may be due to direct effects of different factors encountered in space on lymphoid cells and their interactions. Indeed, in modeled microgravity (MMG) experiments on Earth we and others showed that microgravity directly affects multiple lymphocyte functions. It interferes with expression of cell surface molecules, causes inhibition of lymphocyte locomotion, suppresses polyclopal and antigen-specific lymphocyte activation, selectively inhibits protein kinase C (PKC) isoforms. Some of these effects were also confirmed in cell culture experiments in real space conditions during Spacelab, Biokosmos and Shuttle Missions. The results of these studies, taken together, strongly indicated that microgravity interferes with fundamental biological processes associated with functional and structural changes in cell surface membranes, cell surface molecules and in their interaction. Based on the data and on their interpretation, we hypothesized that microgravity in addition to observed functional changes affects programmed cell death (PCD) in lymphocyte populations and that this mechanism could contribute to the impairment of the immunity.

14 CFR § 1214.115 - Standard services.

Code of Federal Regulations, 2014 CFR

2014-01-01

...§ 1214.115 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT General Provisions Regarding Space Shuttle Flights of Payloads for Non-U.S. Government, Reimbursable Customers § 1214.... (d) A five-person flight crew: commander, pilot and three mission specialists. (e) Orbiter flight...

Effects of the space flight environment on the immune system

NASA Technical Reports Server (NTRS)

Sonnenfeld, Gerald; Butel, Janet S.; Shearer, William T.

2003-01-01

Space flight conditions have a dramatic effect on a variety of physiologic functions of mammals, including muscle, bone, and neurovestibular function. Among the physiological functions that are affected when humans or animals are exposed to space flight conditions is the immune response. The focus of this review is on the function of the immune system in space flight conditions during actual space flights, as well as in models of space flight conditions on the earth. The experiments were carried out in tissue culture systems, in animal models, and in human subjects. The results indicate that space flight conditions alter cell-mediated immune responses, including lymphocyte proliferation and subset distribution, and cytokine production. The mechanism(s) of space flight-induced alterations in immune system function remain(s) to be established. It is likely, however, that multiple factors, including microgravity, stress, neuroendocrine factors, sleep disruption, and nutritional factors, are involved in altering certain functions of the immune system. Such alterations could lead to compromised defenses against infections and tumors.

Working group written presentation: Solar radiation

NASA Technical Reports Server (NTRS)

Slemp, Wayne S.

1989-01-01

The members of the Solar Radiation Working Group arrived at two major solar radiation technology needs: (1) generation of a long term flight data base; and (2) development of a standardized UV testing methodology. The flight data base should include 1 to 5 year exposure of optical filters, windows, thermal control coatings, hardened coatings, polymeric films, and structural composites. The UV flux and wavelength distribution, as well as particulate radiation flux and energy, should be measured during this flight exposure. A standard testing methodology is needed to establish techniques for highly accelerated UV exposure which will correlate well with flight test data. Currently, UV can only be accelerated to about 3 solar constants and can correlate well with flight exposure data. With space missions to 30 years, acceleration rates of 30 to 100X are needed for efficient laboratory testing.

Sub-orbital commercial Human space flight and informed consent in the United States

NASA Astrophysics Data System (ADS)

Carminati, Maria-Vittoria « Giugi »; Griffith, Doug; Campbell, Mark R.

2013-12-01

Commercial space flight is expected to rapidly develop in the near future. This will begin with sub-orbital missions and then progress to orbital flights. In the United States, technical informed consent of space flight participants is required by the commercial space flight operator for regulatory purposes. Additionally, though not required by U.S. regulation, the aerospace medicine professional involved in the medical screening of both space flight participants and crewmembers will be asked to assist operators in obtaining medical informed consent for liability purposes. The various US federal and state regulations regarding informed consent for sub-orbital commercial space flight are evolving and are unfamiliar to most aerospace medical professionals and are reviewed and discussed.

Operational improvements of long-term predicted ephemerides of the Tracking and Data Relay Satellites (TDRSs)

NASA Technical Reports Server (NTRS)

Kostoff, J. L.; Ward, D. T.; Cuevas, O. O.; Beckman, R. M.

1995-01-01

Tracking and Data Relay Satellite (TDRS) orbit determination and prediction are supported by the Flight Dynamics Facility (FDF) of the Goddard Space Flight Center (GSFC) Flight Dynamics Division (FDD). TDRS System (TDRSS)-user satellites require predicted TDRS ephemerides that are up to 10 weeks in length. Previously, long-term ephemerides generated by the FDF included predictions from the White Sands Complex (WSC), which plans and executes TDRS maneuvers. TDRSs typically have monthly stationkeeping maneuvers, and predicted postmaneuver state vectors are received from WSC up to a month in advance. This paper presents the results of an analysis performed in the FDF to investigate more accurate and economical long-term ephemerides for the TDRSs. As a result of this analysis, two new methods for generating long-term TDRS ephemeris predictions have been implemented by the FDF. The Center-of-Box (COB) method models a TDRS as fixed at the center of its stationkeeping box. Using this method, long-term ephemeris updates are made semiannually instead of weekly. The impulse method is used to model more maneuvers. The impulse method yields better short-term accuracy than the COB method, especially for larger stationkeeping boxes. The accuracy of the impulse method depends primarily on the accuracy of maneuver date forecasting.

Space Launch System Spacecraft and Payload Elements: Progress Toward Crewed Launch and Beyond

NASA Technical Reports Server (NTRS)

Schorr, Andrew A.; Creech, Stephen D.

2017-01-01

While significant and substantial progress continues to be accomplished toward readying the Space Launch System (SLS) rocket for its first test flight, work is already also underway on preparations for the second flight - using an upgraded version of the vehicle - and beyond. Designed to support human missions into deep space, Space Launch System (SLS), is the most powerful human-rated launch vehicle the United States has ever undertaken, and is one of three programs being managed by the National Aeronautics and Space Administration's (NASA's) Exploration Systems Development division. The Orion spacecraft program is developing a new crew vehicle that will support human missions beyond low Earth orbit (LEO), and the Ground Systems Development and Operations program is transforming Kennedy Space Center into a next-generation spaceport capable of supporting not only SLS but also multiple commercial users. Together, these systems will support human exploration missions into the proving ground of cislunar space and ultimately to Mars. For its first flight, SLS will deliver a near-term heavy-lift capability for the nation with its 70-metric-ton (t) Block 1 configuration. Each element of the vehicle now has flight hardware in production in support of the initial flight of the SLS, which will propel Orion around the moon and back. Encompassing hardware qualification, structural testing to validate hardware compliance and analytical modeling, progress in on track to meet the initial targeted launch date. In Utah and Mississippi, booster and engine testing are verifying upgrades made to proven shuttle hardware. At Michoud Assembly Facility in Louisiana, the world's largest spacecraft welding tool is producing tanks for the SLS core stage. Providing the Orion crew capsule/launch vehicle interface and in-space propulsion via a cryogenic upper stage, the Spacecraft/Payload Integration and Evolution (SPIE) element serves a key role in achieving SLS goals and objectives. The SPIE element marked a major milestone in 2014 with the first flight of original SLS hardware, the Orion Stage Adapter (OSA) which was used on Exploration Flight Test-1 with a design that will be used again on the first flight of SLS. The element has overseen production of the Interim Cryogenic Propulsion Stage (ICPS), an in-space stage derived from the Delta Cryogenic Second Stage, which was manufactured at United Launch Alliance in Decatur, Alabama, prior to being shipped to Florida for flight preparations. Manufacture of the Orion Stage Adapter and the Launch Vehicle Stage Adapter (LVSA) took place at the Friction Stir Facility located at Marshall Space Flight Center in Huntsville, Alabama. Marshall is also home to the Integrated Structural Test of the ICPS, LVSA, and OSA, subjecting the stacked components to simulated stresses of launch. The SPIE Element is also overseeing integration of 13 "CubeSat" secondary payloads that will fly on the first flight of SLS, providing access to deep space regions in a way currently not available to the science community. At the same time as this preparation work is taking place toward the first launch of SLS, however, the Space Launch System Program is actively working toward its second launch. For its second flight, SLS will be upgraded to the more-capable Block 1B configuration. While the Block 1 configuration is capable of delivering more than 70 metric tons to low Earth orbit, the Block 1B vehicle will increase that capability to 105 t. For that flight, the new configuration introduces two major new elements to the vehicle - an Exploration Upper Stage (EUS) that will be used for both ascent and in-space propulsion, and a Universal Stage Adapter (USA) that serves as a "payload bay" for the rocket, allowing the launch of large exploration systems along with the Orion spacecraft. Already, flight hardware is being prepared for the Block 1B vehicle. Welding is taking place on the second rocket's core stage. Flight hardware production has begun on booster components. An RS-25 engine slated for that flight has been tested. Development work is taking place on the Exploration Upper Stage, with contracts in place for both the stage and the RL10 engines which will power it. (The EUS will use four RL10 engines, an increase from one on the ICPS.) For the crew configuration of the Block 1B vehicle, the SLS SPIE element is managing the USA and accompanying Payload Adapter, which will accommodate both large payloads co-manifested with Orion and small-satellite secondary payloads. This co-manifested payload capacity will be instrumental for missions into the Proving Ground around the moon, where NASA will test new systems and demonstrate new capabilities needed for human exploration farther into deep space.

Proteomic Assessment of Fluid Shifts and Association with Visual Impairment and Intracranial Pressure in Twin Astronauts

NASA Technical Reports Server (NTRS)

Rana, Brinda K.; Stenger, Michael B.; Lee, Stuart M. C.; Macias, Brandon R.; Siamwala, Jamila; Piening, Brian Donald; Hook, Vivian; Ebert, Doug; Patel, Hemal; Smith, Scott;

The SCRAM tool-kit

NASA Technical Reports Server (NTRS)

Tamir, David; Flanigan, Lee A.; Weeks, Jack L.; Siewert, Thomas A.; Kimbrough, Andrew G.; Mcclure, Sidney R.

1994-01-01

This paper proposes a new series of on-orbit capabilities to support the near-term Hubble Space Telescope, Extended Duration Orbiter, Long Duration Orbiter, Space Station Freedom, other orbital platforms, and even the future manned Lunar/Mars missions. These proposed capabilities form a toolkit termed Space Construction, Repair, and Maintenance (SCRAM). SCRAM addresses both intra-Vehicular Activity (IVA) and Extra-Vehicular Activity (EVA) needs. SCRAM provides a variety of tools which enable welding, brazing, cutting, coating, heating, and cleaning, as well as corresponding nondestructive examination. Near-term IVA-SCRAM applications include repair and modification to fluid lines, structure, and laboratory equipment inside a shirt-sleeve environment (i.e. inside Spacelab or Space Station). Near-term EVA-SCRAM applications include construction of fluid lines and structural members, repair of punctures by orbital debris, refurbishment of surfaces eroded by contaminants. The SCRAM tool-kit also promises future EVA applications involving mass production tasks automated by robotics and artificial intelligence, for construction of large truss, aerobrake, and nuclear reactor shadow shields structures. The leading candidate tool processes for SCRAM, currently undergoing research and development, include Electron Beam, Gas Tungsten Arc, Plasma Arc, and Laser Beam. A series of strategic space flight experiments would make SCRAM available to help conquer the space frontier.

Long range planning for the development of space flight emergency systems.

NASA Technical Reports Server (NTRS)

Bolger, P. H.; Childs, C. W.

1972-01-01

The importance of long-range planning for space flight emergency systems is pointed out. Factors in emergency systems planning are considered, giving attention to some of the mission classes which have to be taken into account. Examples of the hazards in space flight include fire, decompression, mechanical structure failures, radiation, collision, and meteoroid penetration. The criteria for rescue vehicles are examined together with aspects regarding the conduction of rescue missions. Future space flight programs are discussed, taking into consideration low earth orbit space stations, geosynchronous orbit space stations, lunar operations, manned planetary missions, future space flight vehicles, the space shuttle, special purpose space vehicles, and a reusable nuclear shuttle.

Rodent Studies of Cardiovascular Deconditioning

NASA Technical Reports Server (NTRS)

Shoukas, Artin A.

1999-01-01

Changes in blood pressure can occur for two reasons: 1) A decrease in cardiac output resulting from the altered contractility of the heart or through changes in venous filling pressure via the Frank Starling mechanism or; 2) A change in systemic vascular resistance. The observed changes in cardiac output and blood pressure after long term space flight cannot be entirely explained through changes in contractility or heart rate alone. Therefore, alterations in filling pressure mediated through changes in systemic venous capacitance and arterial resistance function may be important determinants of cardiac output and blood pressure after long term space flight. Our laboratory and previous studies have shown the importance of veno-constriction mediated by the carotid sinus baroreceptor reflex system on overall circulatory homeostasis and in the regulation of cardiac output. Our proposed experiments test the overall hypothesis that alterations in venous capacitance function and arterial resistance by the carotid sinus baroreceptor reflex system are an important determinant of the cardiac output and blood pressure response seen in astronauts after returning to earth from long term exposure to microgravity. This hypothesis is important to our overall understanding of circulatory adjustments made during long term space flight. It also provides a framework for investigating counter measures to reduce the incidence of orthostatic hypotension caused by an attenuation of cardiac output. We continue to use hind limb unweighted (HLU) rat model to simulate the patho physiological effects as they relate to cardiovascular deconditioning in microgravity. We have used this model to address the hypothesis that microgravity induced cardiovascular deconditioning results in impaired vascular responses and that these impaired vascular responses result from abnormal alpha-1 AR signaling. The impaired vascular reactivity results in attenuated blood pressure and cardiac output responses to an orthostatic challenge. We have used in vitro vascular reactivity assays to explore abnormalities in vascular responses in vessels from HLU animals and, cardiac output (CO), blood pressure (BP) and heart rate (HR) measurements to characterize changes in hemodynamics following HLU.

Long Term Missions at the Sun-Earth Libration Point L1: ACE, SOHO, and WIND

NASA Technical Reports Server (NTRS)

Roberts, Craig E.

2011-01-01

Three heliophysics missions - the Solar Heliospheric Observatory (SOHO), the Advanced Composition Explorer (ACE), and the Global Geoscience WIND - have been orbiting the Sun-Earth interior libration point L1 continuously since 1996, 1997, and 2004, respectively. ACE and WIND (both NASA missions) and SOHO (an ESA-NASA joint mission) are all operated from the NASA Goddard Space Flight Center Flight Dynamics Facility. While ACE and SOHO have been dedicated libration point orbiters since their launches, WIND prior to 2004 flew a remarkable 10-year deep-space trajectory that featured 38 targeted lunar flybys. The L1 orbits and the mission histories of the three spacecraft are briefly reviewed, and the station-keeping techniques and orbit maneuver experience are discussed.

Young PHD's in Human Space Flight

NASA Technical Reports Server (NTRS)

Wilson, Eleanor

2002-01-01

The Cooperating Hampton Roads Organizations for Minorities in Engineering (CHROME) in cooperation with the NASA Office of Space Flight, Human Exploration and Development of Space Enterprise sponsored a summer institute, Young PHD#s (Persons Having Dreams) in Human Space Flight. This 3-day institute used the curriculum of a workshop designed for space professionals, 'Human Space Flight-Analysis and Design: An Integrated, Systematic Approach.' The content was tailored to a high school audience. This institute seeks to stimulate the interest of pre-college students in space flight and motivate them to pursue further experiences in this field. Additionally, this institute will serve as a pilot model for a pre- collegiate training program that can be replicated throughout the country. The institute was complemented with a trip to the Goddard Space Flight Center.

MISSE PEACE Polymers Atomic Oxygen Erosion Results

NASA Technical Reports Server (NTRS)

deGroh, Kim, K.; Banks, Bruce A.; McCarthy, Catherine E.; Rucker, Rochelle N.; Roberts, Lily M.; Berger, Lauren A.

2006-01-01

Forty-one different polymer samples, collectively called the Polymer Erosion and Contamination Experiment (PEACE) Polymers, have been exposed to the low Earth orbit (LEO) environment on the exterior of the International Space Station (ISS) for nearly 4 years as part of Materials International Space Station Experiment 2 (MISSE 2). The objective of the PEACE Polymers experiment was to determine the atomic oxygen erosion yield of a wide variety of polymeric materials after long term exposure to the space environment. The polymers range from those commonly used for spacecraft applications, such as Teflon (DuPont) FEP, to more recently developed polymers, such as high temperature polyimide PMR (polymerization of monomer reactants). Additional polymers were included to explore erosion yield dependence upon chemical composition. The MISSE PEACE Polymers experiment was flown in MISSE Passive Experiment Carrier 2 (PEC 2), tray 1, on the exterior of the ISS Quest Airlock and was exposed to atomic oxygen along with solar and charged particle radiation. MISSE 2 was successfully retrieved during a space walk on July 30, 2005, during Discovery s STS-114 Return to Flight mission. Details on the specific polymers flown, flight sample fabrication, pre-flight and post-flight characterization techniques, and atomic oxygen fluence calculations are discussed along with a summary of the atomic oxygen erosion yield results. The MISSE 2 PEACE Polymers experiment is unique because it has the widest variety of polymers flown in LEO for a long duration and provides extremely valuable erosion yield data for spacecraft design purposes.

The Value of Biomedical Simulation Environments to Future Human Space Flight Missions

NASA Technical Reports Server (NTRS)

Mulugeta, Lealem; Myers, Jerry G.; Skytland, Nicholas G.; Platts, Steven H.

2010-01-01

With the ambitious goals to send manned missions to asteroids and onto Mars, substantial work will be required to ensure the well being of the men and women who will undertake these difficult missions. Unlike current International Space Station or Shuttle missions, astronauts will be required to endure long-term exposure to higher levels of radiation, isolation and reduced gravity. These new operation conditions will pose health risks that are currently not well understood and perhaps unanticipated. Therefore, it is essential to develop and apply advanced tools to predict, assess and mitigate potential hazards to astronaut health. NASA s Digital Astronaut Project (DAP) is working to develop and apply computational models of physiologic response to space flight operation conditions over various time periods and environmental circumstances. The collective application and integration of well vetted models assessing the physiology, biomechanics and anatomy is referred to as the Digital Astronaut. The Digital Astronaut simulation environment will serve as a practical working tool for use by NASA in operational activities such as the prediction of biomedical risks and functional capabilities of astronauts. In additional to space flight operation conditions, DAP s work has direct applicability to terrestrial biomedical research by providing virtual environments for hypothesis testing, experiment design, and to reduce animal/human testing. A practical application of the DA to assess pre and post flight responses to exercise is illustrated and the difficulty in matching true physiological responses is discussed.

Time-dependent radiation dose simulations during interplanetary space flights

NASA Astrophysics Data System (ADS)

Dobynde, Mikhail; Shprits, Yuri; Drozdov, Alexander; Hoffman, Jeffrey; Li, Ju

2016-07-01

Space radiation is one of the main concerns in planning long-term interplanetary human space missions. There are two main types of hazardous radiation - Solar Energetic Particles (SEP) and Galactic Cosmic Rays (GCR). Their intensities and evolution depend on the solar activity. GCR activity is most enhanced during solar minimum, while the most intense SEPs usually occur during the solar maximum. SEPs are better shielded with thick shields, while GCR dose is less behind think shields. Time and thickness dependences of the intensity of these two components encourage looking for a time window of flight, when radiation intensity and dose of SEP and GCR would be minimized. In this study we combine state-of-the-art space environment models with GEANT4 simulations to determine the optimal shielding, geometry of the spacecraft, and launch time with respect to the phase of the solar cycle. The radiation environment was described by the time-dependent GCR model, and the SEP spectra that were measured during the period from 1990 to 2010. We included gamma rays, electrons, neutrons and 27 fully ionized elements from hydrogen to nickel. We calculated the astronaut's radiation doses during interplanetary flights using the Monte-Carlo code that accounts for the primary and the secondary radiation. We also performed sensitivity simulations for the assumed spacecraft size and thickness to find an optimal shielding. In conclusion, we present the dependences of the radiation dose as a function of launch date from 1990 to 2010, for flight durations of up to 3 years.

KSC-08pd0153

NASA Image and Video Library

2008-02-01

KENNEDY SPACE CENTER, FLA. -- After signing a framework agreement establishing the terms for future cooperation between NASA and the Indian Space Research Organization, Chairman G. Madhavan Nair (center) is given a tour of the Space Station Processing Facility at NASA's Kennedy Space Center. The agreement establishes the terms for future cooperation between the two agencies in the exploration and use of outer space for peaceful purposes. According to the framework agreement, the two agencies will identify areas of mutual interest and seek to develop cooperative programs or projects in Earth and space science, exploration, human space flight and other activities. In addition to a long history of cooperation in Earth science, NASA and the Indian Space Research Organization also are cooperating on India's first, mission to the moon, Chandrayaan-1, which will be launched later this year. NASA is providing two of the 11 instruments on the spacecraft: the moon mineralogy mapper instrument and the miniature synthetic aperture radar instrument. Photo credit: NASA/Kim Shiflett

KSC-08pd0150

NASA Image and Video Library

2008-02-01

KENNEDY SPACE CENTER, FLA. -- After signing a framework agreement establishing the terms for future cooperation between NASA and the Indian Space Research Organization, Chairman G. Madhavan Nair (center) and other members are given a tour of the Space Station Processing Facility at NASA's Kennedy Space Center. The agreement establishes the terms for future cooperation between the two agencies in the exploration and use of outer space for peaceful purposes. According to the framework agreement, the two agencies will identify areas of mutual interest and seek to develop cooperative programs or projects in Earth and space science, exploration, human space flight and other activities. In addition to a long history of cooperation in Earth science, NASA and the Indian Space Research Organization also are cooperating on India's first, mission to the moon, Chandrayaan-1, which will be launched later this year. NASA is providing two of the 11 instruments on the spacecraft: the moon mineralogy mapper instrument and the miniature synthetic aperture radar instrument. Photo credit: NASA/Kim Shiflett

KSC-08pd0152

NASA Image and Video Library

2008-02-01

KENNEDY SPACE CENTER, FLA. -- After signing a framework agreement establishing the terms for future cooperation between NASA and the Indian Space Research Organization, Chairman G. Madhavan Nair (center) and other members are given a tour of the Space Station Processing Facility at NASA's Kennedy Space Center. The agreement establishes the terms for future cooperation between the two agencies in the exploration and use of outer space for peaceful purposes. According to the framework agreement, the two agencies will identify areas of mutual interest and seek to develop cooperative programs or projects in Earth and space science, exploration, human space flight and other activities. In addition to a long history of cooperation in Earth science, NASA and the Indian Space Research Organization also are cooperating on India's first, mission to the moon, Chandrayaan-1, which will be launched later this year. NASA is providing two of the 11 instruments on the spacecraft: the moon mineralogy mapper instrument and the miniature synthetic aperture radar instrument. Photo credit: NASA/Kim Shiflett

KSC-08pd0151

NASA Image and Video Library

2008-02-01

KENNEDY SPACE CENTER, FLA. -- After signing a framework agreement establishing the terms for future cooperation between NASA and the Indian Space Research Organization, Chairman G. Madhavan Nair (center) and other members are given a tour of the Space Station Processing Facility at NASA's Kennedy Space Center. The agreement establishes the terms for future cooperation between the two agencies in the exploration and use of outer space for peaceful purposes. According to the framework agreement, the two agencies will identify areas of mutual interest and seek to develop cooperative programs or projects in Earth and space science, exploration, human space flight and other activities. In addition to a long history of cooperation in Earth science, NASA and the Indian Space Research Organization also are cooperating on India's first, mission to the moon, Chandrayaan-1, which will be launched later this year. NASA is providing two of the 11 instruments on the spacecraft: the moon mineralogy mapper instrument and the miniature synthetic aperture radar instrument. Photo credit: NASA/Kim Shiflett

Results of the First US Manned Orbital Space Flight

NASA Technical Reports Server (NTRS)

1962-01-01

The results of the first United States manned orbital space flight conducted on February 20, 1962 are presented. The prelaunch activities, spacecraft description, flight operations, flight data, and postflight analyses presented form a continuation of the information previously published for the two United States manned suborbital space flights conducted on May 5, 1961, and July 21, 1961, respectively, by the National Aeronautics and Space Administration.

76 FR 24836 - Regulatory Approach for Commercial Orbital Human Spaceflight

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-03

... regulating commercial human space flight. In December 2006, the FAA issued human space flight regulations in... space flight participants until December 23, 2012, or until a design feature or operating practice has... or serious injury, to crew or space flight participants during a licensed or permitted commercial...

Energy requirements for space flight

NASA Technical Reports Server (NTRS)

Lane, Helen W.

1992-01-01

Both the United States and the Soviet Union perform human space research. This paper reviews data available on energy metabolism in the microgravity of space flight. The level of energy utilization in space seems to be similar to that on earth, as does energy availability. However, despite adequate intake of energy and protein and in-flight exercise, lean body mass was catabolized, as indicated by negative nitrogen balance. Metabolic studies during simulated microgravity (bed rest) and true microgravity in flight have shown changes in blood glucose, fatty acids and insulin concentrations, suggesting that energy metabolism may be altered during space flight. Future research should focus on the interactions of lean body mass, diet and exercise in space, and their roles in energy metabolism during space flight.

Spacecraft Chemical Propulsion Systems at NASA's Marshall Space Flight Center: Heritage and Capabilities

NASA Technical Reports Server (NTRS)

McRight, Patrick S.; Sheehy, Jeffrey A.; Blevins, John A.

2005-01-01

NASA Marshall Space Flight Center (MSFC) is well known for its contributions to large ascent propulsion systems such as the Saturn V and the Space Shuttle. This paper highlights a lesser known but equally rich side of MSFC - its heritage in spacecraft chemical propulsion systems and its current capabilities for in-space propulsion system development and chemical propulsion research. The historical narrative describes the efforts associated with developing upper-stage main propulsion systems such as the Saturn S-IVB as well as orbital maneuvering and reaction control systems such as the S-IVB auxiliary propulsion system, the Skylab thruster attitude control system, and many more recent activities such as Chandra, the Demonstration of Automated Rendezvous Technology, X-37, the X-38 de-orbit propulsion system, the Interim Control Module, the US Propulsion Module, and several technology development activities. Also discussed are MSFC chemical propulsion research capabilities, along with near- and long-term technology challenges to which MSFC research and system development competencies are relevant.

Integrated Studies of Electric Propulsion Engines during Flights in the Earth's Ionosphere

NASA Astrophysics Data System (ADS)

Marov, M. Ya.; Filatyev, A. S.

2018-03-01

Fifty years ago, on October 1, 1966, the first Yantar satellite laboratory with a gas plasma-ion electric propulsion was launched into orbit as part of the Yantar Soviet space program. In 1966-1971, the program launched a total of four laboratories with thrusters operating on argon, nitrogen, and air with jet velocities of 40, 120, and 140 km/s, respectively. These space experiments were the first to demonstrate the long-term stable operation of these thrusters, which exceed chemical rocket engines in specific impulse by an order of magnitude and provide effective jet charge compensation, under the conditions of a real flight at altitudes of 100-400 km. In this article, we have analyzed the potential modern applications of the scientific results obtained by the Yantar space program for the development of air-breathing electric propulsion that ensure the longterm operation of spacecraft in very low orbits.

Gravitational Effects on Signal Transduction

NASA Technical Reports Server (NTRS)

Sytkowski, Arthur J.

1999-01-01

An understanding of the mechanisms by which individual cells perceive gravity and how these cells transduce and respond to gravitational stimuli is critical for the development of long-term manned space flight experiments. We now propose to use a well-characterized model erythroid cell system and to investigate gravitational perturbations of its erythropoietin (Epo) signaling pathway and gene regulation. Cells will be grown at 1-G and in simulated microgravity in the NASA Rotating Wall Vessel bioreactor (RWV). Cell growth and differentiation, the Epo-receptor, the protein kinase C pathway to the c-myc gene, and the protein phosphatase pathway to the c-myb gene will be studied and evaluated as reporters of gravitational stimuli. The results of these experiments will have impact on the problems of 1) gravitational sensing by individual cells, and 2) the anemia of space flight. This ground-based study also will serve as a Space Station Development Study in gravitational effects on intracellular signal transduction.

Long Duration Sorbent Testbed

NASA Technical Reports Server (NTRS)

Howard, David F.; Knox, James C.; Long, David A.; Miller, Lee; Cmaric, Gregory; Thomas, John

2016-01-01

The Long Duration Sorbent Testbed (LDST) is a flight experiment demonstration designed to expose current and future candidate carbon dioxide removal system sorbents to an actual crewed space cabin environment to assess and compare sorption working capacity degradation resulting from long term operation. An analysis of sorbent materials returned to Earth after approximately one year of operation in the International Space Station's (ISS) Carbon Dioxide Removal Assembly (CDRA) indicated as much as a 70% loss of working capacity of the silica gel desiccant material at the extreme system inlet location, with a gradient of capacity loss down the bed. The primary science objective is to assess the degradation of potential sorbents for exploration class missions and ISS upgrades when operated in a true crewed space cabin environment. A secondary objective is to compare degradation of flight test to a ground test unit with contaminant dosing to determine applicability of ground testing.

Potential utilization of the NASA/George C. Marshall Space Flight Center in earthquake engineering research

NASA Technical Reports Server (NTRS)

Scholl, R. E. (Editor)

1979-01-01

Earthquake engineering research capabilities of the National Aeronautics and Space Administration (NASA) facilities at George C. Marshall Space Flight Center (MSFC), Alabama, were evaluated. The results indicate that the NASA/MSFC facilities and supporting capabilities offer unique opportunities for conducting earthquake engineering research. Specific features that are particularly attractive for large scale static and dynamic testing of natural and man-made structures include the following: large physical dimensions of buildings and test bays; high loading capacity; wide range and large number of test equipment and instrumentation devices; multichannel data acquisition and processing systems; technical expertise for conducting large-scale static and dynamic testing; sophisticated techniques for systems dynamics analysis, simulation, and control; and capability for managing large-size and technologically complex programs. Potential uses of the facilities for near and long term test programs to supplement current earthquake research activities are suggested.

Effects of Polyhydroxybutyrate Production on Cell Division

NASA Technical Reports Server (NTRS)

Miller, Kathleen; Rahman, Asif; Hadi, Masood Z.

2015-01-01

Synthetic biological engineering can be utilized to aide the advancement of improved long-term space flight. The potential to use synthetic biology as a platform to biomanufacture desired equipment on demand using the three dimensional (3D) printer on the International Space Station (ISS) gives long-term NASA missions the flexibility to produce materials as needed on site. Polyhydroxybutyrates (PHBs) are biodegradable, have properties similar to plastics, and can be produced in Escherichia coli using genetic engineering. Using PHBs during space flight could assist mission success by providing a valuable source of biomaterials that can have many potential applications, particularly through 3D printing. It is well documented that during PHB production E. coli cells can become significantly elongated. The elongation of cells reduces the ability of the cells to divide and thus to produce PHB. I aim to better understand cell division during PHB production, through the design, building, and testing of synthetic biological circuits, and identify how to potentially increase yields of PHB with FtsZ overexpression, the gene responsible for cell division. Ultimately, an increase in the yield will allow more products to be created using the 3D printer on the ISS and beyond, thus aiding astronauts in their missions.

Space Flight. Teacher Resources.

ERIC Educational Resources Information Center

2001

This teacher's guide contains information, lesson plans, and diverse student learning activities focusing on space flight. The guide is divided into seven sections: (1) "Drawing Activities" (Future Flight; Space Fun; Mission: Draw); (2) "Geography" (Space Places); (3) "History" (Space and Time); (4)…

Pegasus hypersonic flight research

NASA Technical Reports Server (NTRS)

Curry, Robert E.; Meyer, Robert R., Jr.; Budd, Gerald D.

1992-01-01

Hypersonic aeronautics research using the Pegasus air-launched space booster is described. Two areas are discussed in the paper: previously obtained results from Pegasus flights 1 and 2, and plans for future programs. Proposed future research includes boundary-layer transition studies on the airplane-like first stage and also use of the complete Pegasus launch system to boost a research vehicle to hypersonic speeds. Pegasus flight 1 and 2 measurements were used to evaluate the results of several analytical aerodynamic design tools applied during the development of the vehicle as well as to develop hypersonic flight-test techniques. These data indicated that the aerodynamic design approach for Pegasus was adequate and showed that acceptable margins were available. Additionally, the correlations provide insight into the capabilities of these analytical tools for more complex vehicles in which design margins may be more stringent. Near-term plans to conduct hypersonic boundary-layer transition studies are discussed. These plans involve the use of a smooth metallic glove at about the mid-span of the wing. Longer-term opportunities are proposed which identify advantages of the Pegasus launch system to boost large-scale research vehicles to the real-gas hypersonic flight regime.

Parabolic Flight Investigation for Advanced Exercise Concept Hardware Hybrid Ultimate Lifting Kit (HULK)

NASA Technical Reports Server (NTRS)

Weaver, A. S.; Funk, J. H.; Funk, N. W.; Sheehan, C. C.; Humphreys, B. T.; Perusek, G. P.

2015-01-01

Long-duration space flight poses many hazards to the health of the crew. Among those hazards is the physiological deconditioning of the musculoskeletal and cardiovascular systems due to prolonged exposure to microgravity. To combat this erosion of physical condition space flight may take on the crew, the Human Research Program (HRP) is charged with developing Advanced Exercise Concepts to maintain astronaut health and fitness during long-term missions, while keeping device mass, power, and volume to a minimum. The goal of this effort is to preserve the physical capability of the crew to perform mission critical tasks in transit and during planetary surface operations. The HULK is a pneumatic-based exercise system, which provides both resistive and aerobic modes to protect against human deconditioning in microgravity. Its design targeted the International Space Station (ISS) Advanced Resistive Exercise Device (ARED) high level performance characteristics and provides up to 600 foot pounds resitive loading with the capability to allow for eccentric to concentric (E:C) ratios of higher than 1:1 through a DC motor assist component. The device's rowing mode allows for high cadence aerobic activity. The HULK parabolic flight campaign, conducted through the NASA Flight Opportunities Program at Ellington Field, resulted in the creation of device specific data sets including low fidelity motion capture, accelerometry and both inline and ground reaction forces. These data provide a critical link in understanding how to vibration isolate the device in both ISS and space transit applications. Secondarily, the study of human exercise and associated body kinematics in microgravity allows for more complete understanding of human to machine interface designs to allow for maximum functionality of the device in microgravity.

14 CFR 91.109 - Flight instruction; Simulated instrument flight and certain flight tests.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Flight instruction; Simulated instrument flight and certain flight tests. 91.109 Section 91.109 Aeronautics and Space FEDERAL AVIATION... OPERATING AND FLIGHT RULES Flight Rules General § 91.109 Flight instruction; Simulated instrument flight and...

14 CFR 91.109 - Flight instruction; Simulated instrument flight and certain flight tests.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Flight instruction; Simulated instrument flight and certain flight tests. 91.109 Section 91.109 Aeronautics and Space FEDERAL AVIATION... OPERATING AND FLIGHT RULES Flight Rules General § 91.109 Flight instruction; Simulated instrument flight and...

14 CFR 91.109 - Flight instruction; Simulated instrument flight and certain flight tests.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Flight instruction; Simulated instrument flight and certain flight tests. 91.109 Section 91.109 Aeronautics and Space FEDERAL AVIATION... OPERATING AND FLIGHT RULES Flight Rules General § 91.109 Flight instruction; Simulated instrument flight and...

14 CFR 91.109 - Flight instruction; Simulated instrument flight and certain flight tests.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Flight instruction; Simulated instrument flight and certain flight tests. 91.109 Section 91.109 Aeronautics and Space FEDERAL AVIATION... OPERATING AND FLIGHT RULES Flight Rules General § 91.109 Flight instruction; Simulated instrument flight and...

14 CFR 91.109 - Flight instruction; Simulated instrument flight and certain flight tests.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Flight instruction; Simulated instrument flight and certain flight tests. 91.109 Section 91.109 Aeronautics and Space FEDERAL AVIATION... OPERATING AND FLIGHT RULES Flight Rules General § 91.109 Flight instruction; Simulated instrument flight and...

Aerospace Safety Advisory Panel

NASA Technical Reports Server (NTRS)

2001-01-01

This annual report is based on the activities of the Aerospace Safety Advisory Panel in calendar year 2000. During this year, the construction of the International Space Station (ISS) moved into high gear. The launch of the Russian Service Module was followed by three Space Shuttle construction and logistics flights and the deployment of the Expedition One crew. Continuous habitation of the ISS has begun. To date, both the ISS and Space Shuttle programs have met or exceeded most of their flight objectives. In spite of the intensity of these efforts, it is clear that safety was always placed ahead of cost and schedule. This safety consciousness permitted the Panel to devote more of its efforts to examining the long-term picture. With ISS construction accelerating, demands on the Space Shuttle will increase. While Russian Soyuz and Progress spacecraft will make some flights, the Space Shuttle remains the primary vehicle to sustain the ISS and all other U.S. activities that require humans in space. Development of a next generation, human-rated vehicle has slowed due to a variety of technological problems and the absence of an approach that can accomplish the task significantly better than the Space Shuttle. Moreover, even if a viable design were currently available, the realities of funding and development cycles suggest that it would take many years to bring it to fruition. Thus, it is inescapable that for the foreseeable future the Space Shuttle will be the only human-rated vehicle available to the U.S. space program for support of the ISS and other missions requiring humans. Use of the Space Shuttle will extend well beyond current planning, and is likely to continue for the life of the ISS.

An overview of space medicine.

PubMed

Hodkinson, P D; Anderton, R A; Posselt, B N; Fong, K J

2017-12-01

Space medicine is fundamental to the human exploration of space. It supports survival, function and performance in this challenging and potentially lethal environment. It is international, intercultural and interdisciplinary, operating at the boundaries of exploration, science, technology and medicine. Space medicine is also the latest UK specialty to be recognized by the Royal College of Physicians in the UK and the General Medical Council. This review introduces the field of space medicine and describes the different types of spaceflight, environmental challenges, associated medical and physiological effects, and operational medical considerations. It will describe the varied roles of the space medicine doctor, including the conduct of surgery and anaesthesia, and concludes with a vision of the future for space medicine in the UK.Space medicine doctors have a responsibility to space workers and spaceflight participants. These 'flight surgeons' are key in developing mitigation strategies to ensure the safety, health and performance of space travellers in what is an extreme and hazardous environment. This includes all phases from selection, training and spaceflight itself to post-flight rehabilitation and long-term health. The recent recognition of the speciality provides a pathway to train in this fascinating field of medicine and is a key enabler for the UK Government's commercial spaceflight ambition. © Crown copyright 2017.

14 CFR 415.8 - Human space flight.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Human space flight. 415.8 Section 415.8 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE General § 415.8 Human space flight. To obtain a launch license, an...

14 CFR 415.8 - Human space flight.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Human space flight. 415.8 Section 415.8 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE General § 415.8 Human space flight. To obtain a launch license, an...

14 CFR 415.8 - Human space flight.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Human space flight. 415.8 Section 415.8 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE General § 415.8 Human space flight. To obtain a launch license, an...

14 CFR 415.8 - Human space flight.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Human space flight. 415.8 Section 415.8 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE General § 415.8 Human space flight. To obtain a launch license, an...

14 CFR 415.8 - Human space flight.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Human space flight. 415.8 Section 415.8 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE General § 415.8 Human space flight. To obtain a launch license, an...

The Long-Term Performance of SONY Small Batteries without Cell-Balancing

NASA Technical Reports Server (NTRS)

Pearson, Chris; Thwaite, Carl; Curzon, David; Rao, Gopalakrishna

2004-01-01

This viewgraph presentation describes the investigation of individual cell voltage dispersion under LEO and GEO cycling profiles. The contents cover: 1) Background; 2) Test Outline; 3) Single String Test Battery; 4) Goddard Space Flight Center (GSFC) 5Ah Battery; 5) Impedance; 6) Conclusions.

A space transportation system operations model

NASA Technical Reports Server (NTRS)

Morris, W. Douglas; White, Nancy H.

1987-01-01

Presented is a description of a computer program which permits assessment of the operational support requirements of space transportation systems functioning in both a ground- and space-based environment. The scenario depicted provides for the delivery of payloads from Earth to a space station and beyond using upper stages based at the station. Model results are scenario dependent and rely on the input definitions of delivery requirements, task times, and available resources. Output is in terms of flight rate capabilities, resource requirements, and facility utilization. A general program description, program listing, input requirements, and sample output are included.

Gender differences in navigational memory: pilots vs. nonpilots.

PubMed

Verde, Paola; Piccardi, Laura; Bianchini, Filippo; Guariglia, Cecilia; Carrozzo, Paolo; Morgagni, Fabio; Boccia, Maddalena; Di Fiore, Giacomo; Tomao, Enrico

2015-02-01

The coding of space as near and far is not only determined by arm-reaching distance, but is also dependent on how the brain represents the extension of the body space. Recent reports suggest that the dissociation between reaching and navigational space is not limited to perception and action but also involves memory systems. It has been reported that gender differences emerged only in adverse learning conditions that required strong spatial ability. In this study we investigated navigational versus reaching memory in air force pilots and a control group without flight experience. We took into account temporal duration (working memory and long-term memory) and focused on working memory, which is considered critical in the gender differences literature. We found no gender effects or flight hour effects in pilots but observed gender effects in working memory (but not in learning and delayed recall) in the nonpilot population (Women's mean = 5.33; SD= 0.90; Men's mean = 5.54; SD= 0.90). We also observed a difference between pilots and nonpilots in the maintenance of on-line reaching information: pilots (mean = 5.85; SD=0.76) were more efficient than nonpilots (mean = 5.21; SD=0.83) and managed this type of information similarly to that concerning navigational space. In the navigational learning phase they also showed better navigational memory (mean = 137.83; SD=5.81) than nonpilots (mean = 126.96; SD=15.81) and were significantly more proficient than the latter group. There is no gender difference in a population of pilots in terms of navigational abilities, while it emerges in a control group without flight experience. We found also that pilots performed better than nonpilots. This study suggests that once selected, male and female pilots do not differ from each other in visuo-spatial abilities and spatial navigation.

Automatic maintenance payload on board of a Mexican LEO microsatellite

NASA Astrophysics Data System (ADS)

Vicente-Vivas, Esaú; García-Nocetti, Fabián; Mendieta-Jiménez, Francisco

2006-02-01

Few research institutions from Mexico work together to finalize the integration of a technological demonstration microsatellite called Satex, aiming the launching of the first ever fully designed and manufactured domestic space vehicle. The project is based on technical knowledge gained in previous space experiences, particularly in developing GASCAN automatic experiments for NASA's space shuttle, and in some support obtained from the local team which assembled the México-OSCAR-30 microsatellites. Satex includes three autonomous payloads and a power subsystem, each one with a local microcomputer to provide intelligent and dedicated control. It also contains a flight computer (FC) with a pair of full redundancies. This enables the remote maintenance of processing boards from the ground station. A fourth communications payload depends on the flight computer for control purposes. A fifth payload was decided to be developed for the satellite. It adds value to the available on-board computers and extends the opportunity for a developing country to learn and to generate domestic space technology. Its aim is to provide automatic maintenance capabilities for the most critical on-board computer in order to achieve continuous satellite operations. This paper presents the virtual computer architecture specially developed to provide maintenance capabilities to the flight computer. The architecture is periodically implemented by software with a small amount of physical processors (FC processors) and virtual redundancies (payload processors) to emulate a hybrid redundancy computer. Communications among processors are accomplished over a fault-tolerant LAN. This allows a versatile operating behavior in terms of data communication as well as in terms of distributed fault tolerance. Obtained results, payload validation and reliability results are also presented.

Dynamic Load Predictions for Launchers Using Extra-Large Eddy Simulations X-Les

NASA Astrophysics Data System (ADS)

Maseland, J. E. J.; Soemarwoto, B. I.; Kok, J. C.

2005-02-01

Flow-induced unsteady loads can have a strong impact on performance and flight characteristics of aerospace vehicles and therefore play a crucial role in their design and operation. Complementary to costly flight tests and delicate wind-tunnel experiments, unsteady loads can be calculated using time-accurate Computational Fluid Dynamics. A capability to accurately predict the dynamic loads on aerospace structures at flight Reynolds numbers can be of great value for the design and analysis of aerospace vehicles. Advanced space launchers are subject to dynamic loads in the base region during the ascent to space. In particular the engine and nozzle experience aerodynamic pressure fluctuations resulting from massive flow separations. Understanding these phenomena is essential for performance enhancements for future launchers which operate a larger nozzle. A new hybrid RANS-LES turbulence modelling approach termed eXtra-Large Eddy Simulations (X-LES) holds the promise to capture the flow structures associated with massive separations and enables the prediction of the broad-band spectrum of dynamic loads. This type of method has become a focal point, reducing the cost of full LES, driven by the demand for their applicability in an industrial environment. The industrial feasibility of X-LES simulations is demonstrated by computing the unsteady aerodynamic loads on the main-engine nozzle of a generic space launcher configuration. The potential to calculate the dynamic loads is qualitatively assessed for transonic flow conditions in a comparison to wind-tunnel experiments. In terms of turn-around-times, X-LES computations are already feasible within the time-frames of the development process to support the structural design. Key words: massive separated flows; buffet loads; nozzle vibrations; space launchers; time-accurate CFD; composite RANS-LES formulation.

14 CFR 1214.101 - Eligibility for flight of a non-U.S. government reimbursable payload on the Space Shuttle.

Code of Federal Regulations, 2012 CFR

2012-01-01

.... government reimbursable payload on the Space Shuttle. 1214.101 Section 1214.101 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT General Provisions Regarding Space Shuttle... non-U.S. government reimbursable payload on the Space Shuttle. To be eligible for flight on the Space...

14 CFR 1214.101 - Eligibility for flight of a non-U.S. government reimbursable payload on the Space Shuttle.

Code of Federal Regulations, 2013 CFR

2013-01-01

.... government reimbursable payload on the Space Shuttle. 1214.101 Section 1214.101 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT General Provisions Regarding Space Shuttle... non-U.S. government reimbursable payload on the Space Shuttle. To be eligible for flight on the Space...

14 CFR 1214.101 - Eligibility for flight of a non-U.S. government reimbursable payload on the Space Shuttle.

Code of Federal Regulations, 2011 CFR

2011-01-01

.... government reimbursable payload on the Space Shuttle. 1214.101 Section 1214.101 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT General Provisions Regarding Space Shuttle... non-U.S. government reimbursable payload on the Space Shuttle. To be eligible for flight on the Space...

Operational Aspects of Space Radiation Analysis

NASA Technical Reports Server (NTRS)

Weyland, M. D.; Johnson, A. S.; Semones, E. J.; Shelfer, T.; Dardano, C.; Lin, T.; Zapp, N. E.; Rutledge, R.; George, T.

2005-01-01

Minimizing astronaut's short and long-term medical risks arising from exposure to ionizing radiation during space missions is a major concern for NASA's manned spaceflight program, particularly exploration missions. For ethical and legal reasons, NASA follows the "as low as reasonably achievable" (ALARA) principal in managing astronaut's radiation exposures. One implementation of ALARA is the response to space weather events. Of particular concern are energetic solar particle events, and in low Earth orbit (LEO), electron belt enhancements. To properly respond to these events, NASA's Space Radiation Analysis Group (SRAG), in partnership with the NOAA Space Environment Center (SEC), provides continuous flight support during U.S. manned missions. In this partnership, SEC compiles space weather data from numerous ground and space based assets and makes it available in near real-time to SRAG (along with alerts and forecasts), who in turn uses these data as input to models to calculate estimates of the resulting exposure to astronauts. These calculations and vehicle instrument data form the basis for real-time recommendations to flight management. It is also important to implement ALARA during the design phase. In order to appropriately weigh the risks associated with various shielding and vehicle configuration concepts, the expected environment must be adequately characterized for nominal and worst case scenarios for that portion of the solar cycle and point in space. Even with the best shielding concepts and materials in place (unlikely), there will be numerous occasions where the crew is at greater risk due to being in a lower shielded environment (short term transit or lower shielded vehicles, EVAs), so that accurate space weather forecasts and nowcasts, of particles at the relevant energies, will be crucial to protecting crew health and safety.

Near Earth Architectural Options for a Future Deep Space Optical Communications Network

NASA Technical Reports Server (NTRS)

Edwards, B. L.; Liebrecht, P. E.; Fitzgerald, R. J.

2004-01-01

In the near future the National Aeronautics and Space Administration anticipates a significant increase in demand for long-haul communications services from deep space to Earth. Distances will range from 0.1 to 40 AU, with data rate requirements in the 1's to 1000's of Mbits/second. The near term demand is driven by NASA's Space Science Enterprise which wishes to deploy more capable instruments onboard spacecraft and increase the number of deep space missions. The long term demand is driven by missions with extreme communications challenges such as very high data rates from the outer planets, supporting sub-surface exploration, or supporting NASA's Human Exploration and Development of Space Enterprise beyond Earth orbit. Laser communications is a revolutionary communications technology that will dramatically increase NASA's ability to transmit information across the solar system. Lasercom sends information using beams of light and optical elements, such as telescopes and optical amplifiers, rather than RF signals, amplifiers, and antennas. This paper provides an overview of different network options at Earth to meet NASA's deep space lasercom requirements. It is based mainly on work done for the Mars Laser Communications Demonstration Project, a joint project between NASA's Goddard Space Flight Center (GSFC), the Jet Propulsion Laboratory, California Institute of Technology (JPL), and the Massachusetts Institute of Technology Lincoln Laboratory (MIT/LL). It reports preliminary conclusions from the Mars Lasercom Study conducted at MIT/LL and on additional work done for the Tracking and Data Relay Satellite System Continuation Study at GSFC. A lasercom flight terminal will be flown on the Mars Telesat Orbiter (MTO) to be launched by NASA in 2009, and will be the first high rate deep space demonstration of this revolutionary technology.

Space Launch System Spacecraft and Payload Elements: Progress Toward Crewed Launch and Beyond

NASA Technical Reports Server (NTRS)

Schorr, Andrew A.; Smith, David Alan; Holcomb, Shawn; Hitt, David

2017-01-01

While significant and substantial progress continues to be accomplished toward readying the Space Launch System (SLS) rocket for its first test flight, work is already underway on preparations for the second flight - using an upgraded version of the vehicle - and beyond. Designed to support human missions into deep space, SLS is the most powerful human-rated launch vehicle the United States has ever undertaken, and is one of three programs being managed by the National Aeronautics and Space Administration's (NASA's) Exploration Systems Development division. The Orion spacecraft program is developing a new crew vehicle that will support human missions beyond low Earth orbit (LEO), and the Ground Systems Development and Operations (GSDO) program is transforming Kennedy Space Center (KSC) into a next-generation spaceport capable of supporting not only SLS but also multiple commercial users. Together, these systems will support human exploration missions into the proving ground of cislunar space and ultimately to Mars. For its first flight, SLS will deliver a near-term heavy-lift capability for the nation with its 70-metric-ton (t) Block 1 configuration. Each element of the vehicle now has flight hardware in production in support of the initial flight of the SLS, which will propel Orion around the moon and back. Encompassing hardware qualification, structural testing to validate hardware compliance and analytical modeling, progress is on track to meet the initial targeted launch date. In Utah and Mississippi, booster and engine testing are verifying upgrades made to proven shuttle hardware. At Michoud Assembly Facility (MAF) in Louisiana, the world's largest spacecraft welding tool is producing tanks for the SLS core stage. Providing the Orion crew capsule/launch vehicle interface and in-space propulsion via a cryogenic upper stage, the Spacecraft/Payload Integration and Evolution (SPIE) element serves a key role in achieving SLS goals and objectives. The SPIE element marked a major milestone in 2014 with the first flight of original SLS hardware, the Orion Stage Adapter (OSA) which was used on Exploration Flight Test-1 with a design that will be used again on the first flight of SLS. The element has overseen production of the Interim Cryogenic Propulsion Stage (ICPS), an in-space stage derived from the Delta Cryogenic Second Stage, which was manufactured at United Launch Alliance (ULA) in Decatur, Alabama, prior to being shipped to Florida for flight preparations. Manufacture of the OSA and the Launch Vehicle Stage Adapter (LVSA) took place at the Friction Stir Facility located at Marshall Space Flight Center (MSFC) in Huntsville, Alabama. Marshall is also home to the Integrated Structural Test of the ICPS, LVSA, and OSA, subjecting the stacked components to simulated stresses of launch. The SPIE Element is also overseeing integration of 13 "CubeSat" secondary payloads that will fly on the first flight of SLS, providing access to deep space regions in a way currently not available to the science community. At the same time as this preparation work is taking place toward the first launch of SLS, however, the Space Launch System Program is actively working toward its second launch. For its second flight, SLS will be upgraded to the more-capable Block 1B configuration. While the Block 1 configuration is capable of delivering more than 70 t to LEO, the Block 1B vehicle will increase that capability to 105 t. For that flight, the new configuration introduces two major new elements to the vehicle - an Exploration Upper Stage (EUS) that will be used for both ascent and in-space propulsion, and a Universal Stage Adapter (USA) that serves as a "payload bay" for the rocket, allowing the launch of large exploration systems along with the Orion spacecraft. Already, flight hardware is being prepared for the Block 1B vehicle. Welding is taking place on the second rocket's core stage. Flight hardware production has begun on booster components. An RS-25 engine slated for that flight has been tested. Development work is taking place on the EUS, with contracts in place for both the stage and the RL10 engines which will power it. (The EUS will use four RL10 engines, an increase from one on the ICPS.) For the crew configuration of the Block 1B vehicle, the SLS SPIE element is managing the USA and accompanying Payload Adapter, which will accommodate both large payloads co-manifested with Orion and small-satellite secondary payloads. This co-manifested payload capacity will be instrumental for missions into the proving ground around the moon, where NASA will test new systems and demonstrate new capabilities needed for human exploration farther into deep space.

State of the art survey of network operating systems development

NASA Technical Reports Server (NTRS)

1985-01-01

The results of the State-of-the-Art Survey of Network Operating Systems (NOS) performed for Goddard Space Flight Center are presented. NOS functional characteristics are presented in terms of user communication data migration, job migration, network control, and common functional categories. Products (current or future) as well as research and prototyping efforts are summarized. The NOS products which are revelant to the space station and its activities are evaluated.

An Operational Wake Vortex Sensor Using Pulsed Coherent Lidar

NASA Technical Reports Server (NTRS)

Barker, Ben C., Jr.; Koch, Grady J.; Nguyen, D. Chi

1998-01-01

NASA and FAA initiated a program in 1994 to develop methods of setting spacings for landing aircraft by incorporating information on the real-time behavior of aircraft wake vortices. The current wake separation standards were developed in the 1970's when there was relatively light airport traffic and a logical break point by which to categorize aircraft. Today's continuum of aircraft sizes and increased airport packing densities have created a need for re-evaluation of wake separation standards. The goals of this effort are to ensure that separation standards are adequate for safety and to reduce aircraft spacing for higher airport capacity. Of particular interest are the different requirements for landing under visual flight conditions and instrument flight conditions. Over the years, greater spacings have been established for instrument flight than are allowed for visual flight conditions. Preliminary studies indicate that the airline industry would save considerable money and incur fewer passenger delays if a dynamic spacing system could reduce separations at major hubs during inclement weather to the levels routinely achieved under visual flight conditions. The sensor described herein may become part of this dynamic spacing system known as the "Aircraft VOrtex Spacing System" (AVOSS) that will interface with a future air traffic control system. AVOSS will use vortex behavioral models and short-term weather prediction models in order to predict vortex behavior sufficiently into the future to allow dynamic separation standards to be generated. The wake vortex sensor will periodically provide data to validate AVOSS predictions. Feasibility of measuring wake vortices using a lidar was first demonstrated using a continuous wave (CW) system from NASA Marshall Space Flight Sensor and tested at the Volpe National Transportation Systems Center's wake vortex test site at JFK International Airport. Other applications of CW lidar for wake vortex measurement have been made more recently, including a system developed by the MIT Lincoln Laboratory. This lidar has been used for detailed measurements of wake vortex velocities in support of wake vortex model validation. The first measurements of wake vortices using a pulsed, lidar were made by Coherent Technologies, Inc. (CTI) using a 2 micron solid-state, flashlamp-pumped system operating at 5 Hz. This system was first deployed at Denver's Stapleton Airport. Pulsed lidar has been selected as the baseline technology for an operational sensor due to its longer range capability.

Results from the Joint US/Russian Sensory-Motor Investigations

NASA Technical Reports Server (NTRS)

1997-01-01

In this session, Session FA3, the discussion focuses on the following topics: The Effect of Long Duration Space Flight on the Acquisition of Predictable Targets in Three Dimensional Space; Effects of Microgravity on Spinal Reflex Mechanisms; Three Dimensional Head Movement Control During Locomotion After Long-Duration Space Flight; Human Body Shock Wave Transmission Properties After Long Duration Space Flight; Adaptation of Neuromuscular Activation Patterns During Locomotion After Long Duration Space Flight; Balance Control Deficits Following Long-Duration Space Flight; Influence of Weightlessness on Postural Muscular Activity Coordination; and The Use of Inflight Foot Pressure as a Countermeasure to Neuromuscular Degradation.

14 CFR 460.45 - Operator informing space flight participant of risk.

Code of Federal Regulations, 2014 CFR

2014-01-01

... understanding of the hazards and risks of the mission, and each space flight participant must then provide... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Operator informing space flight participant of risk. 460.45 Section 460.45 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL...

14 CFR 460.45 - Operator informing space flight participant of risk.

Code of Federal Regulations, 2013 CFR

2013-01-01

... understanding of the hazards and risks of the mission, and each space flight participant must then provide... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Operator informing space flight participant of risk. 460.45 Section 460.45 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL...

14 CFR 460.45 - Operator informing space flight participant of risk.

Code of Federal Regulations, 2012 CFR

2012-01-01

... understanding of the hazards and risks of the mission, and each space flight participant must then provide... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Operator informing space flight participant of risk. 460.45 Section 460.45 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL...

14 CFR 431.8 - Human space flight.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Human space flight. 431.8 Section 431.8 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH AND REENTRY OF A REUSABLE LAUNCH VEHICLE (RLV) General § 431.8 Human space flight...

14 CFR 431.8 - Human space flight.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Human space flight. 431.8 Section 431.8 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH AND REENTRY OF A REUSABLE LAUNCH VEHICLE (RLV) General § 431.8 Human space flight...

14 CFR 431.8 - Human space flight.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Human space flight. 431.8 Section 431.8 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH AND REENTRY OF A REUSABLE LAUNCH VEHICLE (RLV) General § 431.8 Human space flight...

14 CFR 431.8 - Human space flight.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Human space flight. 431.8 Section 431.8 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH AND REENTRY OF A REUSABLE LAUNCH VEHICLE (RLV) General § 431.8 Human space flight...

14 CFR 431.8 - Human space flight.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Human space flight. 431.8 Section 431.8 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH AND REENTRY OF A REUSABLE LAUNCH VEHICLE (RLV) General § 431.8 Human space flight...

Consequences of contamination of the spacecraft environment: immunologic consequences

NASA Technical Reports Server (NTRS)

Shearer, W. T.

2001-01-01

Long-term space voyages pose numerous known and unknown health hazards, to the human immune system. Well-studied clinical examples of secondary immunodeficiencies created on Earth, lead one to predict that the conditions of prolonged space flight would weaken the human immune responses that normally hold infection and cancer in check. From evidence gathered from humans flown for prolonged periods in space and from human models of space flight studied on Earth it is reasonable to suspect that space travelers to the planet Mars would experience a weakening of immunity. Subtle defects of immune cell structure and function have been observed in astronauts, such as weakening of specific T-lymphocyte recall of specific antigens. Ground-based models also have demonstrated alterations of immune function, such as the elevation of neuroendocrine immune system messengers, interleukin-6, and soluble tumor necrosis factor-alpha receptor in sleep deprivation. Since severe immune compromise the clinical consequences of reactivation of latent virus infections and the development of cancer, has yet to be seen in space flight or in the Earth models, it is extremely important to begin to quantify early changes in immunity to predict the development of immune system collapse with poor clinical outcomes. This approach is designed to validate a number of surrogate markers that will predict trouble ahead. Inherent in this research is the development of countermeasures to reduce the risks of infection and cancer in the first humans going to Mars.

14 CFR 417.219 - Data loss flight time and planned safe flight state analyses.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Data loss flight time and planned safe flight state analyses. 417.219 Section 417.219 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION... flight to a condition where the launch vehicle's hazardous debris impact dispersion extends to any...

14 CFR 417.219 - Data loss flight time and planned safe flight state analyses.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Data loss flight time and planned safe flight state analyses. 417.219 Section 417.219 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION... flight to a condition where the launch vehicle's hazardous debris impact dispersion extends to any...

14 CFR 417.219 - Data loss flight time and planned safe flight state analyses.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Data loss flight time and planned safe flight state analyses. 417.219 Section 417.219 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION... flight to a condition where the launch vehicle's hazardous debris impact dispersion extends to any...

14 CFR 417.219 - Data loss flight time and planned safe flight state analyses.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Data loss flight time and planned safe flight state analyses. 417.219 Section 417.219 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION... flight to a condition where the launch vehicle's hazardous debris impact dispersion extends to any...

14 CFR 417.219 - Data loss flight time and planned safe flight state analyses.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Data loss flight time and planned safe flight state analyses. 417.219 Section 417.219 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION... flight to a condition where the launch vehicle's hazardous debris impact dispersion extends to any...

[Residential colonization of orbital complex "Mir" environment by penicillium chrysogenum and problem of ecological safety in long-term space flight].

PubMed

Viktorov, A N; Novikova, N D; Deshevaia, E A; Bragina, M P; Shnyreva, A V; Sizova, T P; D'iakov, Iu T

1998-01-01

Results of many years of the survey of highly specific evolution of quantitative and species composition of microflora of the MIR environment are reviewed. Analysis of the data enabled listing of microorganisms-declinous fungi with the ability of residential colonization of structural materials of the interior and equipment of habitable modules of the space station. Results of the studies of variability and level of similarity/affinity on the basis of DNA, polymorphism of strains isolated in space flight, convincingly confirmed this characteristic in the Penicillium chrysogenum cultures. In view of the common origin determined from the signs of genetic alliance, the P. chrysogenum strains isolated on MIR in 1995 can be considered descendants of the cultures found at the beginning of the MIR operation. This ecological expansion of P. chrysogenum in the space station environment gains in prominence due to the fact that representative of this particular species known for its active biodestructive nature were, as a rule, detected in the areas where structural materials of the SALYUT and MIR space stations incurred biological degradation.

Water and Energy Dietary Requirements and Endocrinology of Human Space Flight

NASA Technical Reports Server (NTRS)

Lane, Helen W.; Feeback, Daniel L.

2002-01-01

Fluid and energy metabolism and related endocrine changes have been studied nearly from the beginning of human space flight in association with short- and long-duration flights. Fluid and electrolyte nutrition status is affected by many factors including the microgravity environment, stress, changes in body composition, diet, exercise habits, sleep cycles, and ambient temperature and humidity conditions. Space flight exposes astronauts to all these factors and consequently poses significant challenges to establishing dietary water, sodium, potassium, and energy recommendations. The purpose of this article is to review the results of ground-based and space flight research studies that have led to current water, electrolyte, and energy dietary requirements for humans during space flight and to give an overview of related endocrinologic changes that have been observed in humans during short- and long-duration space flight.

Space Flight Software Development Software for Intelligent System Health Management

NASA Technical Reports Server (NTRS)

Trevino, Luis C.; Crumbley, Tim

2004-01-01

The slide presentation examines the Marshall Space Flight Center Flight Software Branch, including software development projects, mission critical space flight software development, software technical insight, advanced software development technologies, and continuous improvement in the software development processes and methods.

Office of Aeronautics and Space Technology preliminary requirements for space science and applications platform studies

NASA Technical Reports Server (NTRS)

1979-01-01

Needs and requirements for a free flying space science and applications platform to host groupings of compatible, extended mission experiments in earth orbit are discussed. A payload model which serves to define a typical set of mission requirements in the form of a descriptive data base is presented along with experiment leval and group level data summarizations and flight schedules. The payload descriptions are grouped by technology into the following categories: communications, materials (long term effect upon), materials technology development, power, sensors, and thermal control.

Flight Hardware Fabricated for Combustion Science in Space

NASA Technical Reports Server (NTRS)

OMalley, Terence F.; Weiland, Karen J.

2005-01-01

NASA Glenn Research Center s Telescience Support Center (TSC) allows researchers on Earth to operate experiments onboard the International Space Station (ISS) and the space shuttles. NASA s continuing investment in the required software, systems, and networks provides distributed ISS ground operations that enable payload developers and scientists to monitor and control their experiments from the Glenn TSC. The quality of scientific and engineering data is enhanced while the long-term operational costs of experiments are reduced because principal investigators and engineering teams can operate their payloads from their home institutions.

14 CFR § 1214.101 - Eligibility for flight of a non-U.S. government reimbursable payload on the Space Shuttle.

Code of Federal Regulations, 2014 CFR

2014-01-01

.... government reimbursable payload on the Space Shuttle. § 1214.101 Section § 1214.101 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT General Provisions Regarding Space Shuttle... non-U.S. government reimbursable payload on the Space Shuttle. To be eligible for flight on the Space...

STS-103 Crew at Breakfast, Suiting, Departing O&C

NASA Technical Reports Server (NTRS)

1999-01-01

The Hubble Space Telescope (HST) team is preparing for NASA's third scheduled service call to Hubble. This mission, STS-103, will launch from Kennedy Space Center aboard the Space Shuttle Discovery. The seven flight crew members for STS-103 are: Commander Curtis L. Brown (his sixth flight), Pilot Scott J. Kelly and European Space Agency (ESA) astronaut Jean-Francois Clervoy (his third flight) will join space walkers Steven L. Smith (his third flight), C. Michael Foale (his fifth flight), John M. Grunsfeld (his third flight) and ESA astronaut Claude Nicollier (his fourth flight). This current video presents a live footage of the seven STS-103 crewmembers eating breakfast, suiting, and departing the O&C (Operations and Checkout) before the 6:50 p.m. lift-off.

Virtual decoupling flight control via real-time trajectory synthesis and tracking

NASA Astrophysics Data System (ADS)

Zhang, Xuefu

The production of the General Aviation industry has declined in the past 25 years. Ironically, however, the increasing demand for air travel as a fast, safe, and high-quality mode of transportation has been far from satisfied. Addressing this demand shortfall with personal air transportation necessitates advanced systems for navigation, guidance, control, flight management, and flight traffic control. Among them, an effective decoupling flight control system will not only improve flight quality, safety, and simplicity, and increase air space usage, but also reduce expenses on pilot initial and current training, and thus expand the current market and explore new markets. Because of the formidable difficulties encountered in the actual decoupling of non-linear, time-variant, and highly coupled flight control systems through traditional approaches, a new approach, which essentially converts the decoupling problem into a real-time trajectory synthesis and tracking problem, is employed. Then, the converted problem is solved and a virtual decoupling effect is achieved. In this approach, a trajectory in inertial space can be predefined and dynamically modified based on the flight mission and the pilot's commands. A feedforward-feedback control architecture is constructed to guide the airplane along the trajectory as precisely as possible. Through this approach, the pilot has much simpler, virtually decoupled control of the airplane in terms of speed, flight path angle and horizontal radius of curvature. To verify and evaluate this approach, extensive computer simulation is performed. A great deal of test cases are designed for the flight control under different flight conditions. The simulation results show that our decoupling strategy is satisfactory and promising, and therefore the research can serve as a consolidated foundation for future practical applications.

Who dares to join a parabolic flight?

NASA Astrophysics Data System (ADS)

Montag, Christian; Zander, Tina; Schneider, Stefan

2016-12-01

Parabolic flights represent an important tool in space research to investigate zero gravity on airplanes. Research on these flights often target psychological and biological processes in humans to investigate if and how we can adapt to this unique environment. This research is costly, hard to conduct and clearly heavily relies on humans participating in experiments in this (unnatural) situation. The present study investigated N =66 participants and N =66 matched control persons to study if participants in such experimental flights differ in terms of their personality traits from non-parabonauts. The main finding of this study demonstrates that parabonauts score significantly lower on harm avoidance, a trait closely linked to being anxious. As anxious humans differ from non-anxious humans in their biology, the present observations need to be taken into account when aiming at the generalizability of psychobiological research findings conducted in zero gravity on parabolic flights.

Enterprise - Free Flight after Separation from 747

NASA Technical Reports Server (NTRS)

1977-01-01

The Space Shuttle prototype Enterprise flies free of NASA's 747 Shuttle Carrier Aircraft (SCA) during one of five free flights carried out at the Dryden Flight Research Facility, Edwards, California in 1977 as part of the Shuttle program's Approach and Landing Tests (ALT). The tests were conducted to verify orbiter aerodynamics and handling characteristics in preparation for orbital flights with the Space Shuttle Columbia. A tail cone over the main engine area of Enterprise smoothed out turbulent airflow during flight. It was removed on the two last free flights to accurately check approach and landing characteristics. The Space Shuttle Approach and Landings Tests (ALT) program allowed pilots and engineers to learn how the Space Shuttle and the modified Boeing 747 Shuttle Carrier Aircraft (SCA) handled during low-speed flight and landing. The Enterprise, a prototype of the Space Shuttles, and the SCA were flown to conduct the approach and landing tests at the NASA Dryden Flight Research Center, Edwards, California, from February to October 1977. The first flight of the program consisted of the Space Shuttle Enterprise attached to the Shuttle Carrier Aircraft. These flights were to determine how well the two vehicles flew together. Five 'captive-inactive' flights were flown during this first phase in which there was no crew in the Enterprise. The next series of captive flights was flown with a flight crew of two on board the prototype Space Shuttle. Only three such flights proved necessary. This led to the free-flight test series. The free-flight phase of the ALT program allowed pilots and engineers to learn how the Space Shuttle handled in low-speed flight and landing attitudes. For these landings, the Enterprise was flown by a crew of two after it was released from the top of the SCA. The vehicle was released at altitudes ranging from 19,000 to 26,000 feet. The Enterprise had no propulsion system, but its first four glides to the Rogers Dry Lake runway provided realistic, in-flight simulations of how subsequent Space Shuttles would be flown at the end of an orbital mission. The fifth approach and landing test, with the Enterprise landing on the Edwards Air Force Base concrete runway, revealed a problem with the Space Shuttle flight control system that made it susceptible to Pilot-Induced Oscillation (PIO), a potentially dangerous control problem during a landing. Further research using other NASA aircraft, especially the F-8 Digital-Fly-By-Wire aircraft, led to correction of the PIO problem before the first orbital flight. The Enterprise's last free-flight was October 26, 1977, after which it was ferried to other NASA centers for ground-based flight simulations that tested Space Shuttle systems and structure.

Enterprise - Free Flight after Separation from 747

NASA Technical Reports Server (NTRS)

1977-01-01

The Space Shuttle prototype Enterprise flies free after being released from NASA's 747 Shuttle Carrier Aircraft (SCA) during one of five free flights carried out at the Dryden Flight Research Center, Edwards, California in 1977, as part of the Shuttle program's Approach and Landing Tests (ALT). The tests were conducted to verify orbiter aerodynamics and handling characteristics in preparation for orbital flights with the Space Shuttle Columbia. A tail cone over the main engine area of Enterprise smoothed out turbulent airflow during flight. It was removed on the two last free flights to accurately check approach and landing characteristics. The Space Shuttle Approach and Landings Tests (ALT) program allowed pilots and engineers to learn how the Space Shuttle and the modified Boeing 747 Shuttle Carrier Aircraft (SCA) handled during low-speed flight and landing. The Enterprise, a prototype of the Space Shuttles, and the SCA were flown to conduct the approach and landing tests at the NASA Dryden Flight Research Center, Edwards, California, from February to October 1977. The first flight of the program consisted of the Space Shuttle Enterprise attached to the Shuttle Carrier Aircraft. These flights were to determine how well the two vehicles flew together. Five 'captive-inactive' flights were flown during this first phase in which there was no crew in the Enterprise. The next series of captive flights was flown with a flight crew of two on board the prototype Space Shuttle. Only three such flights proved necessary. This led to the free-flight test series. The free-flight phase of the ALT program allowed pilots and engineers to learn how the Space Shuttle handled in low-speed flight and landing attitudes. For these landings, the Enterprise was flown by a crew of two after it was released from the top of the SCA. The vehicle was released at altitudes ranging from 19,000 to 26,000 feet. The Enterprise had no propulsion system, but its first four glides to the Rogers Dry Lake runway provided realistic, in-flight simulations of how subsequent Space Shuttles would be flown at the end of an orbital mission. The fifth approach and landing test, with the Enterprise landing on the Edwards Air Force Base concrete runway, revealed a problem with the Space Shuttle flight control system that made it susceptible to Pilot-Induced Oscillation (PIO), a potentially dangerous control problem during a landing. Further research using other NASA aircraft, especially the F-8 Digital-Fly-By-Wire aircraft, led to correction of the PIO problem before the first orbital flight. The Enterprise's last free-flight was October 26, 1977, after which it was ferried to other NASA centers for ground-based flight simulations that tested Space Shuttle systems and structure.

Intersatellite communications optoelectronics research at the Goddard Space Flight Center

NASA Technical Reports Server (NTRS)

Krainak, Michael A.

1992-01-01

A review is presented of current optoelectronics research and development at the NASA Goddard Space Flight Center for high-power, high-bandwidth laser transmitters; high-bandwidth, high-sensitivity optical receivers; pointing, acquisition, and tracking components; and experimental and theoretical system modeling at the NASA Goddard Space Flight Center. Program hardware and space flight opportunities are presented.

NASA Tests 2nd RS-25 Flight Engine for Space Launch System

NASA Image and Video Library

2018-01-16

On Jan. 16, 2018, engineers at NASA’s Stennis Space Center in Mississippi conducted a certification test of another RS-25 engine flight controller on the A-1 Test Stand at Stennis Space Center. The 365-second, full-duration test came a month after the space agency capped a year of RS-25 testing with a flight controller test in mid-December. For the “green run” test the flight controller was installed on RS-25 developmental engine E0528 and fired just as during an actual launch. Once certified, the flight controller will be removed and installed on a flight engine for use by NASA’s new deep-space rocket, the Space Launch System (SLS).

Space Shuttle Projects Overview to Columbia Air Forces War College

NASA Technical Reports Server (NTRS)

Singer, Jody; McCool, Alex (Technical Monitor)

2000-01-01

This paper presents, in viewgraph form, a general overview of space shuttle projects. Some of the topics include: 1) Space Shuttle Projects; 2) Marshall Space Flight Center Space Shuttle Projects Office; 3) Space Shuttle Propulsion systems; 4) Space Shuttle Program Major Sites; 5) NASA Office of Space flight (OSF) Center Roles in Space Shuttle Program; 6) Space Shuttle Hardware Flow; and 7) Shuttle Flights To Date.

Solar Sail Roadmap Mission GN and C Challenges

NASA Technical Reports Server (NTRS)

Heaton, Andrew F.

2005-01-01

The NASA In-Space Propulsion program is funding development work for solar sails to enhance future scientific opportunities. Key to this effort are scientific solar sail roadmap missions identified by peer review. The two near-term missions of interest are L1 Diamond and Solar Polar Imager. Additionally, the New Millennium Program is sponsoring the Space Technology 9 (ST9) demonstration mission. Solar sails are one of five technologies competing for the ST9 flight demonstration. Two candidate solar sail missions have been identified for a potential ST9 flight. All the roadmap missions and candidate flight demonstration missions face various GN&C challenges. A variety of efforts are underway to address these challenges. These include control actuator design and testing, low thrust optimization studies, attitude control system design and modeling, control-structure interaction studies, trajectory control design, and solar radiation pressure model development. Here we survey the various efforts underway and identify a few of specific recent interest and focus.

Movable Ground Based Recovery System for Reuseable Space Flight Hardware

NASA Technical Reports Server (NTRS)

Sarver, George L. (Inventor)

2013-01-01

A reusable space flight launch system is configured to eliminate complex descent and landing systems from the space flight hardware and move them to maneuverable ground based systems. Precision landing of the reusable space flight hardware is enabled using a simple, light weight aerodynamic device on board the flight hardware such as a parachute, and one or more translating ground based vehicles such as a hovercraft that include active speed, orientation and directional control. The ground based vehicle maneuvers itself into position beneath the descending flight hardware, matching its speed and direction and captures the flight hardware. The ground based vehicle will contain propulsion, command and GN&C functionality as well as space flight hardware landing cushioning and retaining hardware. The ground based vehicle propulsion system enables longitudinal and transverse maneuverability independent of its physical heading.

Animal Enclosure Module (AEM)

NASA Technical Reports Server (NTRS)

1998-01-01

The primary objective of this research project is to test the hypothesis that corticosteroids contribute to the adverse skeletal effects of space flight. To achieve this objective, serum corticosteroids, which are known to increase during space flight, must be maintained at normal physiologic levels in flight rats by a combination of adrenalectomy and corticosteroid supplementation via implanted hormone pellets. Bone analyses in these animals will then be compared to those of intact flight rats that, based on past experience, will undergo corticosteroid excess and bone loss during space flight. The results will reveal whether maintaining serum corticosteroids at physiologic levels in flight rats affects the skeletal abnormalities that normally develop during space flight. A positive response to this question would indicate that the bone loss and decreased bone formation associated with space flight are mediated, at least in part, by corticosteroid excess.

Space transfer services as a precursor to space business parks

NASA Astrophysics Data System (ADS)

Smitherman, David V.

1998-01-01

Boeing Defense and Space Group and NASA, Marshall Space Flight Center conducted a study in 1996-1997 on the topic of commercial space business parks under the sponsorship of the former Office of Advanced Concepts at NASA Headquarters (Marshall 1997). The findings of this 7-month study are used to present possible strategies for near-term commercial developments in space. Related data from NASA studies on public space travel, and commercial space transportation are included along with the author's observations. It is hoped that this analysis will assist future entrepreneurs in the development of commercial space business parks. In conclusion, it appears that a market could soon become viable for commercial space transfer services, and that this market could form the infrastructure to grow the first commercial space business park.

14 CFR 1216.302 - Definition of key terms.

Code of Federal Regulations, 2011 CFR

2011-01-01

... performing in-house R&D and for planning, managing, and supporting contractor and grantee R&D), and for other... related facility equipment; design of facilities projects; and advance planning related to future facilities needs. (4) Space Flight, Control and Data Communications (SFCDC). Has similar scope to R&D but...

14 CFR 1216.302 - Definition of key terms.

Code of Federal Regulations, 2012 CFR

2012-01-01

... performing in-house R&D and for planning, managing, and supporting contractor and grantee R&D), and for other... related facility equipment; design of facilities projects; and advance planning related to future facilities needs. (4) Space Flight, Control and Data Communications (SFCDC). Has similar scope to R&D but...

14 CFR 1216.302 - Definition of key terms.

Code of Federal Regulations, 2010 CFR

2010-01-01

... performing in-house R&D and for planning, managing, and supporting contractor and grantee R&D), and for other... related facility equipment; design of facilities projects; and advance planning related to future facilities needs. (4) Space Flight, Control and Data Communications (SFCDC). Has similar scope to R&D but...

National Centers for Environmental Prediction (NCEP)

Science.gov Websites

Tropical Marine Fire Weather Forecast Maps Unified Surface Analysis Climate Climate Prediction Climate forecasts of hazardous flight conditions at all levels within domestic and international air space. Climate Prediction Center monitors and forecasts short-term climate fluctuations and provides information on the

Mission and Assets Database

NASA Technical Reports Server (NTRS)

Baldwin, John; Zendejas, Silvino; Gutheinz, Sandy; Borden, Chester; Wang, Yeou-Fang

2009-01-01

Mission and Assets Database (MADB) Version 1.0 is an SQL database system with a Web user interface to centralize information. The database stores flight project support resource requirements, view periods, antenna information, schedule, and forecast results for use in mid-range and long-term planning of Deep Space Network (DSN) assets.

Application of "FLUOR-P" device for analysis of the space flight effects on the intracellular level.

NASA Astrophysics Data System (ADS)

Grigorieva, Olga; Rudimov, Evgeny; Buravkova, Ludmila; Galchuk, Sergey

The mechanisms of cellular gravisensitivity still remain unclear despite the intensive research in the hypogravity effects on cellular function. In most cell culture experiments on unmanned vehicles "Bion" and "Photon", as well as on the ISS only allow post-flight analysis of biological material, including fixed cells is provided. The dynamic evaluation cellular parameters over a prolonged period of time is not possible. Thus, a promising direction is the development of equipment for onboard autonomous experiments. For this purpose, the SSC RF IBMP RAS has developed "FLUOR-P" device for measurement and recording of the dynamic differential fluorescent signal from nano- and microsized objects of organic and inorganic nature (human and animal cells, unicellular algae, bacteria, cellular organelles suspension) in hermetically sealed cuvettes. Besides, the device allows to record the main physical factors affecting the analyzed object (temperature and gravity loads: position in space, any vector acceleration, shock) in sync with the main measurements. The device is designed to perform long-term programmable autonomous experiments in space flight on biological satellites. The device software of allows to carry out complex experiments using cell. Permanent registration of data on built-in flash will give the opportunity to analyze the dynamics of the estimated parameters. FLUOR-P is designed as a monobloc (5.5 kg weight), 8 functional blocks are located in the inner space of the device. Each registration unit of the FLUOR-P has two channels of fluorescence intensity and excitation light source with the wavelength range from 300 nm to 700 nm. During biosatellite "Photon" flight is supposed to conduct a full analysis of the most important intracellular parameters (mitochondria activity and intracellular pH) dynamics under space flight factors and to assess the possible contribution of temperature on the effects of microgravity. Work is supported by Roskosmos and the Russian Academy of Sciences.

The biological effects of space radiation during long stays in space.

PubMed

Ohnishi, Ken; Ohnishi, Takeo

2004-12-01

Many space experiments are scheduled for the International Space Station (ISS). Completion of the ISS will soon become a reality. Astronauts will be exposed to low-level background components from space radiation including heavy ions and other high-linear energy transfer (LET) radiation. For long-term stay in space, we have to protect human health from space radiation. At the same time, we should recognize the maximum permissible doses of space radiation. In recent years, physical monitoring of space radiation has detected about 1 mSv per day. This value is almost 150 times higher than that on the surface of the Earth. However, the direct effects of space radiation on human health are currently unknown. Therefore, it is important to measure biological dosimetry to calculate relative biological effectiveness (RBE) for human health during long-term flight. The RBE is possibly modified by microgravity. In order to understand the exact RBE and any interaction with microgravity, the ISS centrifugation system will be a critical tool, and it is hoped that this system will be in operation as soon as possible.

Cultural ethology as a new approach of interplanetary crew's behavior

NASA Astrophysics Data System (ADS)

Tafforin, Carole; Giner Abati, Francisco

2017-10-01

From an evolutionary perspective, during short-term and medium-term orbital flights, human beings developed new spatial and motor behaviors to compensate for the lack of terrestrial gravity. Past space ethological studies have shown adaptive strategies to the tri-dimensional environment, with the goal of optimizing relationships between the astronaut and unusual sensorial-motor conditions. During a long-term interplanetary journey, crewmembers will have to develop new individual and social behaviors to adapt, far from earth, to isolation and confinement and as a result to extreme conditions of living and working together. Recent space psychological studies pointed out that heterogeneity is a feature of interplanetary crews, based on personality, gender mixing, internationality and diversity of backgrounds. Intercultural issues could arise between space voyagers. As a new approach we propose to emphasize the behavioral strategies of human groups' adaptation to this new multicultural dimension of the environment.

Flight Test Results from the NF-15B Intelligent Flight Control System (IFCS) Project with Adaptation to a Simulated Stabilator Failure

NASA Technical Reports Server (NTRS)

Bosworth, John T.; Williams-Hayes, Peggy S.

2007-01-01

Adaptive flight control systems have the potential to be more resilient to extreme changes in airplane behavior. Extreme changes could be a result of a system failure or of damage to the airplane. A direct adaptive neural-network-based flight control system was developed for the National Aeronautics and Space Administration NF-15B Intelligent Flight Control System airplane and subjected to an inflight simulation of a failed (frozen) (unmovable) stabilator. Formation flight handling qualities evaluations were performed with and without neural network adaptation. The results of these flight tests are presented. Comparison with simulation predictions and analysis of the performance of the adaptation system are discussed. The performance of the adaptation system is assessed in terms of its ability to decouple the roll and pitch response and reestablish good onboard model tracking. Flight evaluation with the simulated stabilator failure and adaptation engaged showed that there was generally improvement in the pitch response; however, a tendency for roll pilot-induced oscillation was experienced. A detailed discussion of the cause of the mixed results is presented.

Flight Test Results from the NF-15B Intelligent Flight Control System (IFCS) Project with Adaptation to a Simulated Stabilator Failure

NASA Technical Reports Server (NTRS)

Bosworth, John T.; Williams-Hayes, Peggy S.

2010-01-01

Adaptive flight control systems have the potential to be more resilient to extreme changes in airplane behavior. Extreme changes could be a result of a system failure or of damage to the airplane. A direct adaptive neural-network-based flight control system was developed for the National Aeronautics and Space Administration NF-15B Intelligent Flight Control System airplane and subjected to an inflight simulation of a failed (frozen) (unmovable) stabilator. Formation flight handling qualities evaluations were performed with and without neural network adaptation. The results of these flight tests are presented. Comparison with simulation predictions and analysis of the performance of the adaptation system are discussed. The performance of the adaptation system is assessed in terms of its ability to decouple the roll and pitch response and reestablish good onboard model tracking. Flight evaluation with the simulated stabilator failure and adaptation engaged showed that there was generally improvement in the pitch response; however, a tendency for roll pilot-induced oscillation was experienced. A detailed discussion of the cause of the mixed results is presented.

Gravitropism and development of wild-type and starch-deficient mutants of Arabidopsis during spaceflight

NASA Technical Reports Server (NTRS)

Kiss, J. Z.; Katembe, W. J.; Edelmann, R. E.

1998-01-01

The "starch-statolith" hypothesis has been used by plant physiologists to explain the gravity perception mechanism in higher plants. In order to help resolve some of the controversy associated with ground-based research that has supported this theory, we performed a spaceflight experiment during the January 1997 mission of the Space Shuttle STS-81. Seedlings of wild-type (WT) Arabidopsis, two reduced-starch strains, and a starchless mutant were grown in microgravity and then given a gravity stimulus on a centrifuge. In terms of development in space, germination was greater than 90% for seeds in microgravity, and flight seedlings were smaller (60% in total length) compared to control plants grown on the ground and to control plants on a rotating clinostat. Seedlings grown in space had two structural features that distinguished them from the controls: a greater density of root hairs and an anomalous hypocotyl hook structure. However, the slower growth and morphological changes observed in the flight seedlings may be due to the effects of ethylene present in the spacecraft. Nevertheless, during the flight hypocotyls of WT seedlings responded to a unilateral 60 min stimulus provided by a 1-g centrifuge while those of the starch-deficient strains did not. Thus the strain with the greatest amount of starch responded to the stimulus given in flight and therefore, these data support the starch-statolith model for gravity sensing.

STS-125 Flight Controllers on Console During HST Grapple - Orbit 1. Flight Director: Tony Ceccacci

NASA Image and Video Library

2009-05-13

JSC2009-E-119745 (13 May 2009) --- Flight director Tony Ceccacci (left) and astronaut Dan Burbank, STS-125 spacecraft communicator (CAPCOM), monitor data at their consoles in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center during flight day three activities. The Hubble Space Telescope, grappled by Space Shuttle Atlantis? remote manipulator system (RMS), is visible on one of the big screens.

STS-125 Flight Controllers on Console During HST Grapple - Orbit 1. Flight Director: Tony Ceccacci

NASA Image and Video Library

2009-05-13

JSC2009-E-119746 (13 May 2009) --- Flight director Tony Ceccacci (left) and astronaut Dan Burbank, STS-125 spacecraft communicator (CAPCOM), monitor data at their consoles in the space shuttle flight control room in the Mission Control Center at NASA's Johnson Space Center during flight day three activities. The Hubble Space Telescope, grappled by Space Shuttle Atlantis? remote manipulator system (RMS), is visible on one of the big screens.

Enterprise - Free Flight after Separation from 747

NASA Technical Reports Server (NTRS)

1977-01-01

The Space Shuttle prototype Enterprise flies free after being released from NASA's 747 Shuttle Carrier Aircraft (SCA) over Rogers Dry Lake during the second of five free flights carried out at the Dryden Flight Research Center, Edwards, California, as part of the Shuttle program's Approach and Landing Tests (ALT) in 1977. The tests were conducted to verify orbiter aerodynamics and handling characteristics in preparation for orbital flights with the Space Shuttle Columbia. A tail cone over the main engine area of Enterprise smoothed out turbulent airflow during flight. It was removed on the two last free flights to accurately check approach and landing characteristics. A series of test flights during which Enterprise was taken aloft atop the SCA, but was not released, preceded the free flight tests. The Space Shuttle Approach and Landings Tests (ALT) program allowed pilots and engineers to learn how the Space Shuttle and the modified Boeing 747 Shuttle Carrier Aircraft (SCA) handled during low-speed flight and landing. The Enterprise, a prototype of the Space Shuttles, and the SCA were flown to conduct the approach and landing tests at the NASA Dryden Flight Research Center, Edwards, California, from February to October 1977. The first flight of the program consisted of the Space Shuttle Enterprise attached to the Shuttle Carrier Aircraft. These flights were to determine how well the two vehicles flew together. Five 'captive-inactive' flights were flown during this first phase in which there was no crew in the Enterprise. The next series of captive flights was flown with a flight crew of two on board the prototype Space Shuttle. Only three such flights proved necessary. This led to the free-flight test series. The free-flight phase of the ALT program allowed pilots and engineers to learn how the Space Shuttle handled in low-speed flight and landing attitudes. For these landings, the Enterprise was flown by a crew of two after it was released from the top of the SCA. The vehicle was released at altitudes ranging from 19,000 to 26,000 feet. The Enterprise had no propulsion system, but its first four glides to the Rogers Dry Lake runway provided realistic, in-flight simulations of how subsequent Space Shuttles would be flown at the end of an orbital mission. The fifth approach and landing test, with the Enterprise landing on the Edwards Air Force Base concrete runway, revealed a problem with the Space Shuttle flight control system that made it susceptible to Pilot-Induced Oscillation (PIO), a potentially dangerous control problem during a landing. Further research using other NASA aircraft, especially the F-8 Digital-Fly-By-Wire aircraft, led to correction of the PIO problem before the first orbital flight. The Enterprise's last free-flight was October 26, 1977, after which it was ferried to other NASA centers for ground-based flight simulations that tested Space Shuttle systems and structure.

14 CFR 121.493 - Flight time limitations: Flight engineers and flight navigators.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Flight time limitations: Flight engineers and flight navigators. 121.493 Section 121.493 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Flight Time...

14 CFR 121.493 - Flight time limitations: Flight engineers and flight navigators.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Flight time limitations: Flight engineers and flight navigators. 121.493 Section 121.493 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Flight Time...

14 CFR 121.493 - Flight time limitations: Flight engineers and flight navigators.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Flight time limitations: Flight engineers and flight navigators. 121.493 Section 121.493 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Flight Time...

14 CFR 121.493 - Flight time limitations: Flight engineers and flight navigators.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight time limitations: Flight engineers and flight navigators. 121.493 Section 121.493 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Flight Time...

14 CFR 121.493 - Flight time limitations: Flight engineers and flight navigators.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Flight time limitations: Flight engineers and flight navigators. 121.493 Section 121.493 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Flight Time...

Microbial Cellulose Assembly in Microgravity

NASA Technical Reports Server (NTRS)

Brown, R. Malcolm, Jr.

1998-01-01

Based on evidence indicating a possible correlation between hypo-gravity conditions and alteration of cellulose production by the gram negative bacterium, Acetobacter xylinum, a ground-based study for a possible long term Space Shuttle flight has been conducted. The proposed experiment for A. xylinum aboard the Shuttle is the BRIC (Biological Research in a Canister), a metal container containing spaces for nine Petri plates. Using a common experimental design, the cellulose production capability as well as the survivability of the A. xylinum strains NQ5 and AY201 have been described. It should now be possible to use the BRIC for the first long term microgravity experiments involving the biosynthesis of cellulose.

Acquisition of a Biomedical Database of Acute Responses to Space Flight during Commercial Personal Suborbital Flights

NASA Technical Reports Server (NTRS)

Charles, John B.; Richard, Elizabeth E.

2010-01-01

There is currently too little reproducible data for a scientifically valid understanding of the initial responses of a diverse human population to weightlessness and other space flight factors. Astronauts on orbital space flights to date have been extremely healthy and fit, unlike the general human population. Data collection opportunities during the earliest phases of space flights to date, when the most dynamic responses may occur in response to abrupt transitions in acceleration loads, have been limited by operational restrictions on our ability to encumber the astronauts with even minimal monitoring instrumentation. The era of commercial personal suborbital space flights promises the availability of a large (perhaps hundreds per year), diverse population of potential participants with a vested interest in their own responses to space flight factors, and a number of flight providers interested in documenting and demonstrating the attractiveness and safety of the experience they are offering. Voluntary participation by even a fraction of the flying population in a uniform set of unobtrusive biomedical data collections would provide a database enabling statistical analyses of a variety of acute responses to a standardized space flight environment. This will benefit both the space life sciences discipline and the general state of human knowledge.

The main goals of experiments with the higher plants in the project MARS - 500.

NASA Astrophysics Data System (ADS)

Sychev, Vladimir; Levinskikh, Margarita; Podolsky, Igor; Gushin, Vadim; Bingham, Gail; Bates, Scott

At the present step of development of manned flight to Mars there is a current opinion that including a greenhouse in the composition of Life Support Systems (LSS) of Martian expedition would essentially improve a spacecraft habitat conditions and also would have impact to preventing of a number of possible consequences of continuous presence of human in artificial environment. Development of design objectives of future space greenhouses applicable for conditions of Martian expedition should be based, in our opinion, not only on the results of real space experiments, conducted onboard of orbital stations, but also on the results of ground-based experiments. In connection with above considerations there is a number of technological, biological and psychological experiments is planned to be conducted in the frame of MARS-500 project to resolve questions related to incorporation of higher plants in LSS of inter-planetary flights. The questions include: testing of developed elements of the greenhouse construction and methods for cultivation of vegetables under conditions of imitation of the flight of Martian expedition; selection of breeds and species of vegetables, characterized by high speed of biomass accumulation, attractive taste and appearance; investigation of growth, development and metabolism of plants under long-term continuous cultivation in manned pressurized object; comparison of the productivity of the plants as a function of utilization of different light source; determination of maximum amount of planted biomass of the plants and number of possible vegetation under conditions of long-term utilization of vegetation chamber of the greenhouse without substrate replacement; investigation of crops dietetic preferences of crew members; estimation of quality of plant biomass using seeding of the plants by microorganisms and nitrates and vitamins content as markers; development and approbation of methodical approaches to estimation of psychological factors of influence of vegetating plants on the crew under conditions of continuous stay in pressurized object; investigation of "operator-greenhouse-plants" system as a function of personal characteristics of a crew members, development of possible algorithms of operation of greenhouse hardware in a long-term manned space flights.

Effects of space flight on surface marker expression

NASA Astrophysics Data System (ADS)

Sonnenfeld, G.

1999-01-01

Space flight has been shown to affect expression of several cell surface markers. These markers play important roles in regulation of immune responses, including CD4 and CD8. The studies have involved flight of experimental animals and humans followed by analysis of tissue samples (blood in humans, rats and monkeys, spleen, thymus, lymph nodes and bone marrow in rodents). The degree and direction of the changes induced by space flight have been determined by the conditions of the flight. Also, there may be compartmentalization of the response of surface markers to space flight, with differences in the response of cells isolated from blood and local immune tissue. The same type of compartmentalization was also observed with cell adhesion molecules (integrins). In this case, the expression of integrins from lymph node cells differed from that of splenocytes isolated from rats immediately after space flight. Cell culture studies have indicated that there may be an inhibition in conversion of a precursor cell line to cells exhibiting mature macrophage characteristics after space flight, however, these experiments were limited as a result of technical difficulties. In general, it is clear that space flight results in alterations of cell surface markers. The biological significance of these changes remains to be established.

Cytoskeletal stability and metabolic alterations in primary human macrophages in long-term microgravity.

PubMed

Tauber, Svantje; Lauber, Beatrice A; Paulsen, Katrin; Layer, Liliana E; Lehmann, Martin; Hauschild, Swantje; Shepherd, Naomi R; Polzer, Jennifer; Segerer, Jürgen; Thiel, Cora S; Ullrich, Oliver

2017-01-01

The immune system is one of the most affected systems of the human body during space flight. The cells of the immune system are exceptionally sensitive to microgravity. Thus, serious concerns arise, whether space flight associated weakening of the immune system ultimately precludes the expansion of human presence beyond the Earth's orbit. For human space flight, it is an urgent need to understand the cellular and molecular mechanisms by which altered gravity influences and changes the functions of immune cells. The CELLBOX-PRIME (= CellBox-Primary Human Macrophages in Microgravity Environment) experiment investigated for the first time microgravity-associated long-term alterations in primary human macrophages, one of the most important effector cells of the immune system. The experiment was conducted in the U.S. National Laboratory on board of the International Space Station ISS using the NanoRacks laboratory and Biorack type I standard CELLBOX EUE type IV containers. Upload and download were performed with the SpaceX CRS-3 and the Dragon spaceship on April 18th, 2014 / May 18th, 2014. Surprisingly, primary human macrophages exhibited neither quantitative nor structural changes of the actin and vimentin cytoskeleton after 11 days in microgravity when compared to 1g controls. Neither CD18 or CD14 surface expression were altered in microgravity, however ICAM-1 expression was reduced. The analysis of 74 metabolites in the cell culture supernatant by GC-TOF-MS, revealed eight metabolites with significantly different quantities when compared to 1g controls. In particular, the significant increase of free fucose in the cell culture supernatant was associated with a significant decrease of cell surface-bound fucose. The reduced ICAM-1 expression and the loss of cell surface-bound fucose may contribute to functional impairments, e.g. the activation of T cells, migration and activation of the innate immune response. We assume that the surprisingly small and non-significant cytoskeletal alterations represent a stable "steady state" after adaptive processes are initiated in the new microgravity environment. Due to the utmost importance of the human macrophage system for the elimination of pathogens and the clearance of apoptotic cells, its apparent robustness to a low gravity environment is crucial for human health and performance during long-term space missions.

Cytoskeletal stability and metabolic alterations in primary human macrophages in long-term microgravity

PubMed Central

Tauber, Svantje; Lauber, Beatrice A.; Paulsen, Katrin; Layer, Liliana E.; Lehmann, Martin; Hauschild, Swantje; Shepherd, Naomi R.; Polzer, Jennifer; Segerer, Jürgen; Thiel, Cora S.

2017-01-01

The immune system is one of the most affected systems of the human body during space flight. The cells of the immune system are exceptionally sensitive to microgravity. Thus, serious concerns arise, whether space flight associated weakening of the immune system ultimately precludes the expansion of human presence beyond the Earth's orbit. For human space flight, it is an urgent need to understand the cellular and molecular mechanisms by which altered gravity influences and changes the functions of immune cells. The CELLBOX-PRIME (= CellBox-Primary Human Macrophages in Microgravity Environment) experiment investigated for the first time microgravity-associated long-term alterations in primary human macrophages, one of the most important effector cells of the immune system. The experiment was conducted in the U.S. National Laboratory on board of the International Space Station ISS using the NanoRacks laboratory and Biorack type I standard CELLBOX EUE type IV containers. Upload and download were performed with the SpaceX CRS-3 and the Dragon spaceship on April 18th, 2014 / May 18th, 2014. Surprisingly, primary human macrophages exhibited neither quantitative nor structural changes of the actin and vimentin cytoskeleton after 11 days in microgravity when compared to 1g controls. Neither CD18 or CD14 surface expression were altered in microgravity, however ICAM-1 expression was reduced. The analysis of 74 metabolites in the cell culture supernatant by GC–TOF–MS, revealed eight metabolites with significantly different quantities when compared to 1g controls. In particular, the significant increase of free fucose in the cell culture supernatant was associated with a significant decrease of cell surface–bound fucose. The reduced ICAM-1 expression and the loss of cell surface–bound fucose may contribute to functional impairments, e.g. the activation of T cells, migration and activation of the innate immune response. We assume that the surprisingly small and non-significant cytoskeletal alterations represent a stable “steady state” after adaptive processes are initiated in the new microgravity environment. Due to the utmost importance of the human macrophage system for the elimination of pathogens and the clearance of apoptotic cells, its apparent robustness to a low gravity environment is crucial for human health and performance during long-term space missions. PMID:28419128

Investigation of periodontal tissue during a long space flights

NASA Astrophysics Data System (ADS)

Solovyeva, Zoya; Viacheslav, Ilyin; Skedina, Marina

Previous studies conducted on the International Space Station found that upon completion of the space flight there are significant changes in the local immunity and periodontal microflora of astronauts. Also research in ground-based experiments that simulate space flight factors showed that prolonged hypokinesia antiorthostatic leads to impaired functional indicators of the periodontal vascular system, an unidirectional change from the microbiota and the immune system. That results in the appearance and progressive increase of the parodontial pathogenic bacteria and increase of the content of immunoglobulins in the oral fluid. All these changes are classified as risk factors for the development of inflammatory periodontal diseases in astronauts. However, the studies were unable to determine whether the changes result from a long space flight and the peculiarities of formation the local immunity and periodontal microbiota during the space flight, or they are one of the specific manifestations of the readaptationary post-flight condition of the body. In this regard, the planned research in a long space flight suggests: to use the means of microbial control, which can retain of the anaerobes periodontal microbiota sampling directly in the space flight; to assess the specificity of changes of the periodontal immune status under the influence of the space flight factors, and to assess the state of microcirculation of periodontal tissue in astronauts. A comprehensive study of the reaction of dentition during the space flight will make it possible to study the pathogenesis of changes for developing an adequate prevention aimed at optimizing the state of dentition of the astronauts.

Long-Duration Space Flight Provokes Pathologic Q-Tc Interval Prolongation

NASA Technical Reports Server (NTRS)

D'Aunno, DOminick S.; Dougherty, Anne H.; DeBlock, Heidi F.; Meck, Janice V.

2002-01-01

Space flight has a profound influence on the cardiovascular and autonomic nervous systems. Alterations in baroreflex function, plasma catecholamine concentrations, and arterial pressure regulation have been observed. Changes in autonomic regulation of cardiac function may lead to serious rhythm disturbances. In fact, ventricular tachycardia has been reported during long-duration space flight. The study aim was to determine the effects of space flight on cardiac conduction. Methods and Results: Electrocardiograms (ECGs) and serum electrolytes were obtained before and after short-duration (SD) (4-16 days) and long-duration (LD) (4-6 months) missions. Holter recordings were obtained from 3 different subjects before, during and after a 4-month mission. P-R, R-R, and Q-T intervals were measured manually in a random, blinded fashion and Bazzet's formula used to correct the Q-T interval (Q-Tc). Space flight had no clinically significant effect on electrolyte concentrations. P-R and RR intervals were decreased after SD flight (p<0.05) and recovered 3 days after landing. In the same subjects, P-R and Q-Tc intervals were prolonged after LD flight (p<0.01). Clinically significant Q-Tc prolongation (>0.44 sec) occurred during the first month of flight and persisted until 3 days after landing (p<0.01). Conclusions - Space flight alters cardiac conduction with more ominous changes seen with LD missions. Alterations in autonomic tone may explain ECG changes associated with space flight. Primary cardiac changes may also contribute to the conduction changes with LD flight. Q-Tc prolongation may predispose astronauts to ventricular arrhythmias during and after long-duration space flight.

The IMISS-1 Experiment for Recording and Analysis of Accelerations in Orbital Flight

NASA Astrophysics Data System (ADS)

Sadovnichii, V. A.; Alexandrov, V. V.; Bugrov, D. I.; Lemak, S. S.; Pakhomov, V. B.; Panasyuk, M. I.; Petrov, V. L.; Yashin, I. V.

2018-03-01

The IMISS-1 experiment represents the second step in solving the problem of the creation of the gaze stabilization corrector. This device is designed to correct the effect of the gaze stabilization delay under microgravity. IMISS-1 continues research started by the Tat'yana-2 satellite. This research will be continued on board the International Space Station. At this stage we study the possibility of registration of angular and linear accelerations acting on the sensitive mass in terms of Low Earth Orbit flight, using MEMS sensors.

Effect of space flight on cytokine production

NASA Astrophysics Data System (ADS)

Sonnenfeld, Gerald

Space flight has been shown to alter many immunological responses. Among those affected are the production of cytokines, Cytokines are the messengers of the immune system that facilitate communication among cells that allow the interaction among cells leading to the development of immune responses. Included among the cytokines are the interferons, interleukins, and colony stimulating factors. Cytokines also facilitate communication between the immune system and other body systems, such as the neuroendocrine and musculoskeletal systems. Some cytokines also have direct protective effects on the host, such as interferon, which can inhibit the replication of viruses. Studies in both humans and animals indicate that models of space flight as well as actual space flight alter the production and action of cytokines. Included among these changes are altered interferon production, altered responsiveness of bone marrow cells to granulocyte/monocyte-colony stimulating factor, but no alteration in the production of interleukin-3. This suggests that there are selective effects of space flight on immune responses, i.e. not all cytokines are affected in the same fashion by space flight. Tissue culture studies also suggest that there may be direct effects of space flight on the cells responsible for cytokine production and action. The results of the above study indicate that the effects of space flight on cytokines may be a fundamental mechanism by which space flight not only affects immune responses, but also other biological systems of the human.

The main changes in plant exposured during space flight missions and prospectives of biological studies on ISS

NASA Astrophysics Data System (ADS)

Nechitailo, Galina S.; Kuznetsov, Anatoli

The fundamental result of biological investigations with plants in space flight is an experimen-tal evidence of vegetative growth from seeds to harvest, with passing of all those stages of development when the plant can be used for food. The changes of plant observed after space flight mission gives a knowledge, which has to be used for precise selection of the plants for future space missions. The experimental investigation of the plants under space flight condi-tions showed that the germinations ability, rate of growth and biometric parameters decrease in comparison with Earth plants. The first two of these factors can be caused by the influence of specific cultivation in space, but the third factor is caused by the influence of space flight conditions, in particular, microgravity. The investigations of germination, plants deaths at var-ious stages of growth, survival probability, and recessive mutations indicated an impairment of genetic apparatus of meristem cells, which results the lethal effect at various stages of develop-ment. The density of paramagnetic centers in seeds was measured in order to determine the free radical concentration under space flight conditions. The concentration of paramagnetic centers is higher for plants with high density of these centers initially. Perhaps, the observed genetic effects in plants under space flight conditions are connected with free radicals. The changes are observed in cells of the plants. The changes included twist, contraction and deformation of the cell walls, curvature and loose arrangement of lamellae in chloroplasts, break of outer membrane of mitochondria and disappearance of mitochondria cristae. A large number of stach grains is observed in chloroplasts. The seeds of various plants were successfully used in space flights: welsh onion, wheat, peas, maize, barley, tomatoes, etc. Mostly stabe plants to space flight factors are found as peas, wheat and tomatoes. Ten generation of wheat and tomatoues exposed in space flights were grown on Earth after flight. The investigation of these plants is used for recommendations of next space flight missions on ISS including new sorts of plants.

Apollo experience report. Crew-support activities for experiments performed during manned space flight

NASA Technical Reports Server (NTRS)

Mckee, J. W.

1974-01-01

Experiments are performed during manned space flights in an attempt to acquire knowledge that can advance science and technology or that can be applied to operational techniques for future space flights. A description is given of the procedures that the personnel who are directly assigned to the function of crew support at the NASA Lyndon B. Johnson Space Center use to prepare for and to conduct experiments during space flight.

Research and Technology, 1987, Goddard Space Flight Center

NASA Technical Reports Server (NTRS)

Guerny, Gene (Editor); Moe, Karen (Editor); Paddack, Steven (Editor); Soffen, Gerald (Editor); Sullivan, Walter (Editor); Ballard, Jan (Editor)

1987-01-01

Research at Goddard Space Flight Center during 1987 is summarized. Topics addressed include space and earth sciences, technology, flight projects and mission definition studies, and institutional technology.

Current Characteristics and Trends of the Tracked Satellite Population in the Human Space Flight Regime

NASA Technical Reports Server (NTRS)

Johnson, Nicholas L.

2006-01-01

Since the end of the Apollo program in 1972, human space flight has been restricted to altitudes below 600 km above the Earth s surface with most missions restricted to a ceiling below 400 km. An investigation of the tracked satellite population transiting and influencing the human space flight regime during the past 11 years (equivalent to a full solar cycle) has recently been completed. The overall effects of satellite breakups and solar activity are typically less pronounced in the human space flight regime than other regions of low Earth orbit. As of January 2006 nearly 1500 tracked objects resided in or traversed the human space flight regime, although two-thirds of these objects were in orbits of moderate to high eccentricity, significantly reducing their effect on human space flight safety. During the period investigated, the spatial density of tracked objects in the 350-400 km altitude regime of the International Space Station demonstrated a steady decline, actually decreasing by 50% by the end of the period. On the other hand, the region immediately above 600 km experienced a significant increase in its population density. This regime is important for future risk assessments, since this region represents the reservoir of debris which will influence human space flight safety in the future. The paper seeks to put into sharper perspective the risks posed to human space flight by the tracked satellite population, as well as the influences of solar activity and the effects of compliance with orbital debris mitigation guidelines on human space flight missions. Finally, the methods and successes of characterizing the population of smaller debris at human space flight regimes are addressed.

14 CFR 121.425 - Flight engineers: Initial and transition flight training.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Flight engineers: Initial and transition flight training. 121.425 Section 121.425 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... § 121.425 Flight engineers: Initial and transition flight training. (a) Initial and transition flight...

14 CFR 121.425 - Flight engineers: Initial and transition flight training.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Flight engineers: Initial and transition flight training. 121.425 Section 121.425 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... § 121.425 Flight engineers: Initial and transition flight training. (a) Initial and transition flight...

14 CFR 121.426 - Flight navigators: Initial and transition flight training.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Flight navigators: Initial and transition flight training. 121.426 Section 121.426 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... § 121.426 Flight navigators: Initial and transition flight training. (a) Initial and transition flight...

14 CFR 121.426 - Flight navigators: Initial and transition flight training.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight navigators: Initial and transition flight training. 121.426 Section 121.426 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... § 121.426 Flight navigators: Initial and transition flight training. (a) Initial and transition flight...

14 CFR 121.425 - Flight engineers: Initial and transition flight training.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Flight engineers: Initial and transition flight training. 121.425 Section 121.425 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... § 121.425 Flight engineers: Initial and transition flight training. (a) Initial and transition flight...

14 CFR 121.426 - Flight navigators: Initial and transition flight training.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Flight navigators: Initial and transition flight training. 121.426 Section 121.426 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... § 121.426 Flight navigators: Initial and transition flight training. (a) Initial and transition flight...