View of STS-129 MS2 Bresnik and MS4 Satcher during EVA3

NASA Image and Video Library

2009-11-23

S129-E-008248 (23 Nov. 2009) --- Astronauts Randy Bresnik (right) and Robert L. Satcher Jr. (top left), both STS-129 mission specialists, participate in the mission's third and final session of extravehicular activity (EVA) as construction and maintenance continue on the International Space Station. During the five-hour, 42-minute spacewalk, Bresnik and Satcher removed a pair of micrometeoroid and orbital debris shields from the Quest airlock and strapped them to the External Stowage Platform #2, then moved an articulating foot restraint to the airlock, and released a bolt on a starboard truss ammonia tank assembly (ATA) in preparation for an STS-131 spacewalk that will replace the ATA.

View of STS-129 MS2 Bresnik during EVA3

NASA Image and Video Library

2009-11-23

S129-E-008010 (23 Nov. 2009) --- Astronaut Randy Bresnik, STS-129 mission specialist, participates in the mission's third and final session of extravehicular activity (EVA) as construction and maintenance continue on the International Space Station. During the five-hour, 42-minute spacewalk, Bresnik and astronaut Robert L. Satcher Jr. (out of frame), mission specialist, removed a pair of micrometeoroid and orbital debris shields from the Quest airlock and strapped them to the External Stowage Platform #2, then moved an articulating foot restraint to the airlock, and released a bolt on a starboard truss ammonia tank assembly (ATA) in preparation for an STS-131 spacewalk that will replace the ATA.

View of STS-129 MS4 Satcher during EVA3

NASA Image and Video Library

2009-11-23

S129-E-008103 (23 Nov. 2009) --- Astronaut Robert L. Satcher Jr., STS-129 mission specialist, participates in the mission's third and final session of extravehicular activity (EVA) as construction and maintenance continue on the International Space Station. During the five-hour, 42-minute spacewalk, Satcher and astronaut Randy Bresnik (out of frame), mission specialist, removed a pair of micrometeoroid and orbital debris shields from the Quest airlock and strapped them to the External Stowage Platform #2, then moved an articulating foot restraint to the airlock, and released a bolt on a starboard truss ammonia tank assembly (ATA) in preparation for an STS-131 spacewalk that will replace the ATA.

View of STS-129 MS4 Satcher during EVA3

NASA Image and Video Library

2009-11-23

ISS021-E-031705 (23 Nov. 2009) --- Astronaut Robert L. Satcher Jr., STS-129 mission specialist, participates in the mission's third and final session of extravehicular activity (EVA) as construction and maintenance continue on the International Space Station. During the five-hour, 42-minute spacewalk, Satcher and astronaut Randy Bresnik (out of frame), mission specialist, removed a pair of micrometeoroid and orbital debris shields from the Quest airlock and strapped them to the External Stowage Platform #2, then moved an articulating foot restraint to the airlock, and released a bolt on a starboard truss ammonia tank assembly (ATA) in preparation for an STS-131 spacewalk that will replace the ATA.

View of STS-129 MS4 Satcher during EVA3

NASA Image and Video Library

2009-11-23

S129-E-008115 (23 Nov. 2009) --- Astronaut Robert L. Satcher Jr., STS-129 mission specialist, participates in the mission's third and final session of extravehicular activity (EVA) as construction and maintenance continue on the International Space Station. During the five-hour, 42-minute spacewalk, Satcher and astronaut Randy Bresnik (out of frame), mission specialist, removed a pair of micrometeoroid and orbital debris shields from the Quest airlock and strapped them to the External Stowage Platform #2, then moved an articulating foot restraint to the airlock, and released a bolt on a starboard truss ammonia tank assembly (ATA) in preparation for an STS-131 spacewalk that will replace the ATA.

Automated Remote Monitoring of Depression: Acceptance Among Low-Income Patients in Diabetes Disease Management.

PubMed

Ramirez, Magaly; Wu, Shinyi; Jin, Haomiao; Ell, Kathleen; Gross-Schulman, Sandra; Myerchin Sklaroff, Laura; Guterman, Jeffrey

2016-01-25

Remote patient monitoring is increasingly integrated into health care delivery to expand access and increase effectiveness. Automation can add efficiency to remote monitoring, but patient acceptance of automated tools is critical for success. From 2010 to 2013, the Diabetes-Depression Care-management Adoption Trial (DCAT)-a quasi-experimental comparative effectiveness research trial aimed at accelerating the adoption of collaborative depression care in a safety-net health care system-tested a fully automated telephonic assessment (ATA) depression monitoring system serving low-income patients with diabetes. The aim of this study was to determine patient acceptance of ATA calls over time, and to identify factors predicting long-term patient acceptance of ATA calls. We conducted two analyses using data from the DCAT technology-facilitated care arm, in which for 12 months the ATA system periodically assessed depression symptoms, monitored treatment adherence, prompted self-care behaviors, and inquired about patients' needs for provider contact. Patients received assessments at 6, 12, and 18 months using Likert-scale measures of willingness to use ATA calls, preferred mode of reach, perceived ease of use, usefulness, nonintrusiveness, privacy/security, and long-term usefulness. For the first analysis (patient acceptance over time), we computed descriptive statistics of these measures. In the second analysis (predictive factors), we collapsed patients into two groups: those reporting "high" versus "low" willingness to use ATA calls. To compare them, we used independent t tests for continuous variables and Pearson chi-square tests for categorical variables. Next, we jointly entered independent factors found to be significantly associated with 18-month willingness to use ATA calls at the univariate level into a logistic regression model with backward selection to identify predictive factors. We performed a final logistic regression model with the identified significant predictive factors and reported the odds ratio estimates and 95% confidence intervals. At 6 and 12 months, respectively, 89.6% (69/77) and 63.7% (49/77) of patients "agreed" or "strongly agreed" that they would be willing to use ATA calls in the future. At 18 months, 51.0% (64/125) of patients perceived ATA calls as useful and 59.7% (46/77) were willing to use the technology. Moreover, in the first 6 months, most patients reported that ATA calls felt private/secure (75.9%, 82/108) and were easy to use (86.2%, 94/109), useful (65.1%, 71/109), and nonintrusive (87.2%, 95/109). Perceived usefulness, however, decreased to 54.1% (59/109) in the second 6 months of the trial. Factors predicting willingness to use ATA calls at the 18-month follow-up were perceived privacy/security and long-term perceived usefulness of ATA calls. No patient characteristics were significant predictors of long-term acceptance. In the short term, patients are generally accepting of ATA calls for depression monitoring, with ATA call design and the care management intervention being primary factors influencing patient acceptance. Acceptance over the long term requires that the system be perceived as private/secure, and that it be constantly useful for patients' needs of awareness of feelings, self-care reminders, and connectivity with health care providers. ClinicalTrials.gov NCT01781013; https://clinicaltrials.gov/ct2/show/NCT01781013 (Archived by WebCite at http://www.webcitation.org/6e7NGku56).

Automated Remote Monitoring of Depression: Acceptance Among Low-Income Patients in Diabetes Disease Management

PubMed Central

Ramirez, Magaly; Jin, Haomiao; Ell, Kathleen; Gross-Schulman, Sandra; Myerchin Sklaroff, Laura; Guterman, Jeffrey

2016-01-01

Background Remote patient monitoring is increasingly integrated into health care delivery to expand access and increase effectiveness. Automation can add efficiency to remote monitoring, but patient acceptance of automated tools is critical for success. From 2010 to 2013, the Diabetes-Depression Care-management Adoption Trial (DCAT)–a quasi-experimental comparative effectiveness research trial aimed at accelerating the adoption of collaborative depression care in a safety-net health care system–tested a fully automated telephonic assessment (ATA) depression monitoring system serving low-income patients with diabetes. Objective The aim of this study was to determine patient acceptance of ATA calls over time, and to identify factors predicting long-term patient acceptance of ATA calls. Methods We conducted two analyses using data from the DCAT technology-facilitated care arm, in which for 12 months the ATA system periodically assessed depression symptoms, monitored treatment adherence, prompted self-care behaviors, and inquired about patients’ needs for provider contact. Patients received assessments at 6, 12, and 18 months using Likert-scale measures of willingness to use ATA calls, preferred mode of reach, perceived ease of use, usefulness, nonintrusiveness, privacy/security, and long-term usefulness. For the first analysis (patient acceptance over time), we computed descriptive statistics of these measures. In the second analysis (predictive factors), we collapsed patients into two groups: those reporting “high” versus “low” willingness to use ATA calls. To compare them, we used independent t tests for continuous variables and Pearson chi-square tests for categorical variables. Next, we jointly entered independent factors found to be significantly associated with 18-month willingness to use ATA calls at the univariate level into a logistic regression model with backward selection to identify predictive factors. We performed a final logistic regression model with the identified significant predictive factors and reported the odds ratio estimates and 95% confidence intervals. Results At 6 and 12 months, respectively, 89.6% (69/77) and 63.7% (49/77) of patients “agreed” or “strongly agreed” that they would be willing to use ATA calls in the future. At 18 months, 51.0% (64/125) of patients perceived ATA calls as useful and 59.7% (46/77) were willing to use the technology. Moreover, in the first 6 months, most patients reported that ATA calls felt private/secure (75.9%, 82/108) and were easy to use (86.2%, 94/109), useful (65.1%, 71/109), and nonintrusive (87.2%, 95/109). Perceived usefulness, however, decreased to 54.1% (59/109) in the second 6 months of the trial. Factors predicting willingness to use ATA calls at the 18-month follow-up were perceived privacy/security and long-term perceived usefulness of ATA calls. No patient characteristics were significant predictors of long-term acceptance. Conclusions In the short term, patients are generally accepting of ATA calls for depression monitoring, with ATA call design and the care management intervention being primary factors influencing patient acceptance. Acceptance over the long term requires that the system be perceived as private/secure, and that it be constantly useful for patients’ needs of awareness of feelings, self-care reminders, and connectivity with health care providers. Trial Registration ClinicalTrials.gov NCT01781013; https://clinicaltrials.gov/ct2/show/NCT01781013 (Archived by WebCite at http://www.webcitation.org/6e7NGku56) PMID:26810139

Beam Research Program

DTIC Science & Technology

1984-04-01

wavelengths. A direct application of such a laser is isotope separation. 2. For a brief status report of the Laboratory’s high- explosive flash...operation in the fall of 1982. in a 50-MeV Advanced Test Accelerator Facility (the ATA)1 that we are con- structing at our high- explosives test loca...chemical explosives in target-damage studies. Potential hazards associated with the ATA experiments were considered in choosing our site. LLNL’s

76 FR 15808 - Airworthiness Directives; The Boeing Company Model 737-600, -700, -700C, -800, -900, and -900ER...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-22

... ATA, on behalf of its member airline AAL, expressed concern with the measurement requirements of the... with using common maintenance measurement tools to better allow the operator to comply with these... measurement is four decimal places of accuracy (0.XXXX). AAL stated that this dimension is in Boeing Assembly...

Free radical generation in the brain precedes hyperbaric oxygen-induced convulsions.

PubMed

Torbati, D; Church, D F; Keller, J M; Pryor, W A

1992-01-01

We tested the hypothesis that hyperbaric oxygenation (HBO) generates free radicals in the brain before the onset of neurological manifestations of central nervous system (CNS) oxygen poisoning. Chronically cannulated, conscious rats were individually placed in a transparent pressure chamber and exposed to (1) 5 atmospheres absolute (ATA) oxygen for 15 min (n = 4); (2) 5 ATA oxygen for 30 min (n = 5), during which no visible convulsions occurred; (3) 5 ATA oxygen for 30 min with recurrent convulsions (n = 6); (4) 5 ATA oxygen until the appearance of the first visible convulsions (n = 5); (5) 4 ATA oxygen for 60 min during which no convulsions occurred (n = 5); and (6) 5 ATA air for 30 min (n = 5, controls). Immediately before compression, 1 mL of 0.1 M of alpha-phenyl-N-tert-butyl nitrone (PBN) was administered intravenously (iv) for spin trapping. At the termination of each experiment, rats were euthanized by pentobarbital iv and decompressed within 1 min. Brains were rapidly removed for preparation of lipid extracts (Folch). The presence of PBN spin adducts in the lipid extracts was examined by electron spin resonance (ESR) spectroscopy. ESR spectra from unconvulsed rats exposed to 5 ATA oxygen for 30 min revealed both oxygen-centered and carbon-centered PBN spin adducts in three of the five brains. One of the five rats in this group showed an ascorbyl signal in the ESR spectrum.(ABSTRACT TRUNCATED AT 250 WORDS)

Feasibility study of an attention training application for older adults.

PubMed

Hill, Nikki L; Mogle, Jacqueline; Colancecco, Elise; Dick, Robert; Hannan, John; Lin, Feng Vankee

2015-09-01

Technology-based attention training has demonstrated promise in its potential to improve cognitive functioning in older people. Developing mobile applications, with older users specifically in mind, may support future dissemination of these interventions and integration into daily life. The purpose of this pilot study was to test the feasibility of an Attention Training Application (ATA) for community-dwelling older adults using mobile technology. A descriptive, mixed-methods design was used to capture older adults' feedback on the usability and acceptability of the ATA. A convenience sample of older adults (n = 9) from two independent living facilities participated in a 2-hour training and practice session with the ATA. Participants were given personally tailored instructions for using the mobile device and the ATA specifically. Following a practice session, participants provided ratings on multiple components of the ATA and completed an audio-recorded, semi-structured interview to provide detailed descriptions of their experience and perceptions. An iterative process of content analysis was used to characterise the open-ended responses. Participants rated the ATA favourably overall on several 0-10 scales including likeability [8.5 (1.6)], interest [8.8 (2.3)] and satisfaction [8.2 (1.9)]. The qualitative analyses revealed several issues relevant to the feasibility of the ATA among older people including the importance of the technological background of the user, limiting negative feedback, challenges with the touch screen interface, personal preferences for challenge, extending the practice period and the difficulty of the dual-task condition. The use of the ATA is feasible in the older adult population. Future development should specifically consider personal characteristics as well as preferences to maximise usability and acceptability among older people. Older adults enjoyed the ATA. This opens doors to user-friendly technological interventions that may be effective in assisting older adults maintain and possibly even improve their cognitive function. © 2015 John Wiley & Sons Ltd.

EEG patterns associated with nitrogen narcosis (breathing air at 9 ATA).

PubMed

Pastena, Lucio; Faralli, Fabio; Mainardi, Giovanni; Gagliardi, Riccardo

2005-11-01

The narcotic effect of nitrogen impairs diver performance and limits dive profiles, especially for deep dives using compressed air. It would be helpful to establish measurable correlates of nitrogen narcosis. The authors observed the electroencephalogram (EEG) of 10 subjects, ages 22-27 yr, who breathed air during a 3-min compression to a simulated depth of 80 msw (9 ATA). The EEG from a 19-electrode cap was recorded for 20 min while the subject reclined on a cot with eyes closed, first at 1 ATA before the dive and again at 9 ATA. Signals were analyzed using Fast Fourier Transform and brain mapping for frequency domains 0-4 Hz, 4-7 Hz, 7-12 Hz, and 12-15 Hz. Student's paired t-test and correlation tests were used to compare results for the two conditions. Two EEG patterns were observed. The first was an increase in delta and theta activity in all cortical regions that appeared in the first 2 min at depth and was related to exposure time. The second was an increase in delta and theta activity and shifting of alpha activity to the frontal regions at minute 6 of breathing air at 9 ATA and was related to the narcotic effects of nitrogen. If confirmed by studies with larger case series, this EEG pattern could be used to identify nitrogen narcosis for various gas mixtures and prevent the dangerous impact of nitrogen on diver performance.

A Tool for Stateful Replay

DTIC Science & Technology

2013-03-01

DOWNLOAD .........................76 D. TEST 3 – SAME NETWORK TRACE, DIFFERENT TCP FLOW ...86 E. TEST 4 – LARGE FILE DOWNLOAD FROM WEB .............96 V...AC1( Data 1 .. 8 ~ !!. :: ~ ACK Data 3 ~ • ~~ n ata 2·Data 3 ~ >·5 I~ n , " ~ ~ -o,,.’ ~ ACKOata 3 • "~ .. ~ < . ~ ~· ’ ~ .... ~ )II...8217---: ACK Oata 61 ;£.Y.. Oat a 31 ...,. .:<: ["" D~ta 63 Da ta 32~ ata 6l .CK ... , ACK Oata 62 -’-- - I"’ < ’ o.,. 64 Data 63 ACK Data63

Thyroid Hormone Treatment

MedlinePlus

... Home About the ATA Work of the ATA Leadership & Staff Governance Society Awards Society Committees Clark T. ... Home About the ATA Work of the ATA Leadership & Staff Governance Society Awards Society Committees Clark T. ...

American Thyroid Association

MedlinePlus

... Home About the ATA Work of the ATA Leadership & Staff Governance Society Awards Society Committees Clark T. ... Home About the ATA Work of the ATA Leadership & Staff Governance Society Awards Society Committees Clark T. ...

Find an Endocrinology - Thyroid Specialist

MedlinePlus

... Home About the ATA Work of the ATA Leadership & Staff Governance Society Awards Society Committees Clark T. ... Home About the ATA Work of the ATA Leadership & Staff Governance Society Awards Society Committees Clark T. ...

Acknowledging gray areas: 2015 vs. 2009 American Thyroid Association differentiated thyroid cancer guidelines on ablating putatively low-intermediate-risk patients.

PubMed

Frangos, Savvas; Iakovou, Ioannis P; Marlowe, Robert J; Eftychiou, Nicolaos; Patsali, Loukia; Vanezi, Anna; Savva, Androulla; Mpalaris, Vassilis; Giannoula, Evanthia I

2017-02-01

Typically formulated by investigators from "world centres of excellence," differentiated thyroid carcinoma (DTC) management guidelines may have more limited applicability in settings of less expert care and fewer resources. Arguably the world's leading DTC guidelines are those of the American Thyroid Association, revised in 2009 ("ATA 2009") and 2015 ("ATA 2015"). To further explore the issue of "real-world applicability" of DTC guidelines, we retrospectively compared indications for ablation using ATA 2015 versus ATA 2009 in a two-centre cohort of ablated T1-2, M0 DTC patients (N = 336). Based on TNM status and histology, these patients were low-intermediate risk, but many ultimately had other characteristics suggesting elevated or uncertain risk. Working by consensus, two experienced nuclear medicine physicians considered patient and treatment characteristics to classify each case as having "no indication," a "possible indication," or a "clear indication" for ablation according to ATA 2009 or ATA 2015. The physicians also identified reasons for classification changes between ATA 2015 versus ATA 2009. Classification was unblinded, but the physicians had cared for only 138/336 patients, and the charts encompassed September 2010-October 2013, several years before the classification was performed. One hundred of 336 patients (29.8 %) changed classification regarding indication for ablation using ATA 2015 versus ATA 2009. Most reclassified patients (70/100) moved from "no indication" or "clear indication" to "possible indication." Reflecting this phenomenon, "possible indication" became the largest category according to the ATA 2015 classification (141/336, 42.0 %, versus 96/336, 28.6 %, according to ATA 2009). Many reclassifications were attributable to multiple clinicopathological characteristics, most commonly, stimulated thyroglobulin or anti-thyroglobulin antibody levels, multifocality, bilateral involvement, or capsular/nodal invasion. Regarding indications for ablation, ATA 2015 appears to better "acknowledge grey areas," i.e., patients with ambiguous or unavailable data requiring individualised, nuanced decision-making, than does ATA 2009.

The effects of respiratory muscle training on respiratory mechanics and energy cost.

PubMed

Held, Heather E; Pendergast, David R

2014-08-15

Resistance respiratory muscle training (RRMT) increases respiratory muscle strength and can increase swimming endurance time by as much as 85%. The purpose of this study was to examine potential mechanisms by which RRMT improves exercise endurance. Eight healthy adult male scuba divers underwent experiments in a hyperbaric chamber at sea level (1 atmosphere absolute (ATA)), 2.7 ATA and 4.6 ATA, both dry and fully submersed. Subjects rested, exercised, and rested while mimicking their own exercise breathing (ISEV). Airway resistance (R(aw)), exhaled nitric oxide output (V˙(NO)), and respiratory duty cycle (T(I)/T(Tot)) were determined before and after four weeks of RRMT. RRMT decreased T(I)/T(Tot) (-10% at rest at 1 ATA), V˙(O2) (-17% at 2.7 ATA during submersed exercise), V˙(E) (-6% at 2.7 ATA during submersed exercise), and R(aw) (-34% inspiratory at 4.6 ATA submersed, -38% expiratory at 2.7 ATA dry), independent of changes in V˙(NO). Most importantly, respiratory muscle efficiency increased (+83% at 2.7 ATA submersed). Copyright © 2014 Elsevier B.V. All rights reserved.

Fiber micro-architecture in the longitudinal-radial and circumferential-radial planes of ascending thoracic aortic aneurysm media

PubMed Central

Tsamis, Alkiviadis; Phillippi, Julie A.; Koch, Ryan G.; Pasta, Salvatore; D'Amore, Antonio; Watkins, Simon C.; Wagner, William R.; Gleason, Thomas G.; Vorp, David A.

2013-01-01

It was recently demonstrated by our group that the delamination strength of ascending thoracic aortic aneurysms (ATAA) was lower than that of control (CTRL, non-aneurysmal) ascending thoracic aorta (ATA), and the reduced strength was more pronounced among bicuspid (BAV) vs. tricuspid aortic valve (TAV) patients, suggesting a different risk of aortic dissection for BAV patients. We hypothesized that aortic valve morphologic phenotype predicts fiber micro-architectural anomalies in ATA. To test the hypothesis, we characterized the micro-architecture in the longitudinal-radial (Z-RAD) and circumferential-radial (Θ-RAD) planes of human ATA tissue that was artificially dissected medially. The outer and inner-media of CTRL-ATA, BAV-ATAA and TAV-ATAA were imaged using multi-photon microscopy in the Z-RAD and Θ-RAD planes to observe collagen and elastin. Micrographs were processed using an image-based tool to quantify several micro-architectural characteristics. In the outer-media of BAV-ATAA, elastin was more undulated and less aligned about the Θ-axis when compared with CTRL-ATA, which is consistent with increased tensile stretch at inflection point of Θ-strips of adventitial-medial half of BAV-ATAA (1.28) when compared with CTRL-ATA (1.13). With increasing age, collagen became more undulated about the Z-axis within the outer-media of TAV-ATAA, and elastin became more oriented in the Z-axis and collagen less radially-oriented within the inner-media of TAV-ATAA. This discrepancy in the micro-architecture with fibers in the inner layers being more stretched and with disrupted radially-oriented components than fibers in the outer layers may be associated with the development, progression and vascular remodeling in aneurysms arising in TAV patients. PMID:24075403

Fiber micro-architecture in the longitudinal-radial and circumferential-radial planes of ascending thoracic aortic aneurysm media.

PubMed

Tsamis, Alkiviadis; Phillippi, Julie A; Koch, Ryan G; Pasta, Salvatore; D'Amore, Antonio; Watkins, Simon C; Wagner, William R; Gleason, Thomas G; Vorp, David A

2013-11-15

It was recently demonstrated by our group that the delamination strength of ascending thoracic aortic aneurysms (ATAA) was lower than that of control (CTRL, non-aneurysmal) ascending thoracic aorta (ATA), and the reduced strength was more pronounced among bicuspid (BAV) vs. tricuspid aortic valve (TAV) patients, suggesting a different risk of aortic dissection for BAV patients. We hypothesized that aortic valve morphologic phenotype predicts fiber micro-architectural anomalies in ATA. To test the hypothesis, we characterized the micro-architecture in the longitudinal-radial (Z-RAD) and circumferential-radial (Θ-RAD) planes of human ATA tissue that was artificially dissected medially. The outer and inner-media of CTRL-ATA, BAV-ATAA and TAV-ATAA were imaged using multi-photon microscopy in the Z-RAD and Θ-RAD planes to observe collagen and elastin. Micrographs were processed using an image-based tool to quantify several micro-architectural characteristics. In the outer-media of BAV-ATAA, elastin was more undulated and less aligned about the Θ-axis when compared with CTRL-ATA, which is consistent with increased tensile stretch at inflection point of Θ-strips of adventitial-medial half of BAV-ATAA (1.28) when compared with CTRL-ATA (1.13). With increasing age, collagen became more undulated about the Z-axis within the outer-media of TAV-ATAA, and elastin became more oriented in the Z-axis and collagen less radially-oriented within the inner-media of TAV-ATAA. This discrepancy in the micro-architecture with fibers in the inner layers being more stretched and with disrupted radially-oriented components than fibers in the outer layers may be associated with the development, progression and vascular remodeling in aneurysms arising in TAV patients. © 2013 Elsevier Ltd. All rights reserved.

Space Launch System Base Heating Test: Sub-Scale Rocket Engine/Motor Design, Development & Performance Analysis

NASA Technical Reports Server (NTRS)

Mehta, Manish; Seaford, Mark; Kovarik, Brian; Dufrene, Aaron; Solly, Nathan

2014-01-01

ATA-002 Technical Team has successfully designed, developed, tested and assessed the SLS Pathfinder propulsion systems for the Main Base Heating Test Program. Major Outcomes of the Pathfinder Test Program: Reach 90% of full-scale chamber pressure Achieved all engine/motor design parameter requirements Reach steady plume flow behavior in less than 35 msec Steady chamber pressure for 60 to 100 msec during engine/motor operation Similar model engine/motor performance to full-scale SLS system Mitigated nozzle throat and combustor thermal erosion Test data shows good agreement with numerical prediction codes Next phase of the ATA-002 Test Program Design & development of the SLS OML for the Main Base Heating Test Tweak BSRM design to optimize performance Tweak CS-REM design to increase robustness MSFC Aerosciences and CUBRC have the capability to develop sub-scale propulsion systems to meet desired performance requirements for short-duration testing.

Ambulance traffic accidents in Taiwan.

PubMed

Chiu, Po-Wei; Lin, Chih-Hao; Wu, Chen-Long; Fang, Pin-Hui; Lu, Chien-Hsin; Hsu, Hsiang-Chin; Chi, Chih-Hsien

2018-04-01

Ambulance traffic accidents (ATAs) are the leading cause of occupation-related fatalities among emergency medical service (EMS) personnel. We aim to use the Taiwan national surveillance system to analyze the characteristics of ATAs and to assist EMS directors in developing policies governing ambulance operations. A retrospective, cross-sectional and largely descriptive study was conducted using Taiwan national traffic accidents surveillance data from January 1, 2011 to October 31, 2016. Among the 1,627,217 traffic accidents during the study period, 715 ATAs caused 8 deaths within 24 h and 1844 injured patients. On average, there was one ATA for every 8598 ambulance runs. Compared to overall traffic accidents, ATAs were 1.7 times more likely to result in death and 1.9 times more likely to have injured patients. Among the 715 ATAs, 8 (1.1%) ATAs were fatal and 707 (98.9%) were nonfatal. All 8 fatalities were associated with motorcycles. The urban areas were significantly higher than the rural areas in the annual number of ATAs (14.2 ± 7.3 [7.0-26.7] versus 3.1 ± 1.9 [0.5-8.4], p = 0.013), the number of ATA-associated fatalities per year (0.2 ± 0.2 [0.0-0.7] versus 0.1 ± 0.1 [0.0-0.2], p = 0.022), and the annual number of injured patients (who needed urgent hospital visits) in ATAs (19.4 ± 7.3 [10.5-30.9] versus 5.2 ± 3.8 [0.9-15.3], p < 0.001). The ATA-associated fatality rate in Taiwan was high, and all fatalities were associated with motorcycles. ATAs in a highly motorcycle-populated area may require further investigation. An ambulance traffic accident reporting system should be built to provide EMS policy guidance for ATA reduction and outcome improvements. Copyright © 2018. Published by Elsevier B.V.

Use of the Maximum Likelihood Method in the Analysis of Chamber Air Dives

DTIC Science & Technology

1988-01-01

the total gas pressure in compartment i, P0 is the current ambient pressure, 0 [ and A and B are constants (0.0026 min-’ -ATA- and 8.31 ATA...computer model (4), the Kidd- Stubbs 1971 decompression tables (11), and the current Defence and Civil Institute 20 of Environmental Medicine (DCIEM...it could be applied. Since the models are not suitable for this test, then within T ese no-deco current limits of statistical theory, the results can

Characterization of Plasmodium falciparum Choline Transporters

DTIC Science & Technology

2005-04-01

ElO PfCTL v.1 transcript El IE2E31E41 E5 E6EE EJ PfCTL v.2 transcript B 1/1 31/11 61/21 91/31 ATG AAT TAC ATC GAG ATG GAA GA CGT GAA TAT AAA CCA CTT...ATA GA GAA GTGBGAT AAT GGA AC AT ATT ATA ATA MT MC MG GM TAT TAT AAC ATG TAT GA AAC AT MT ATA M N Y I E M4 E E R E Y K P L I EK E V D N G N N I B I N N...GGT ATA AAT TAC MT GGG AM ATA TGT GGA AAG GAT CTA CAT AA TAT CCA TAT TTA TAC TTC CCT CTT ACT CCT MA MT CCT MA CCT GA ATA TTA AGT ACC TAT GCT MA TGC YO G

Quantization of bovine serum albumin by fluorescence enhancement effects and corresponding binding of macrocyclic host-protein assembly.

PubMed

Bardhan, Munmun; Misra, Tapas; Ganguly, Tapan

2012-01-05

The present paper reports the investigations on the spectroscopic behavior of the binary complexes of the dye aurintricarboxylic acid (ATA) with protein bovine serum albumin (BSA) and 18-crown 6 (CW) (ATA·BSA, ATA·CW) and the ternary complex ATA·CW·BSA by using UV-vis steady state and time resolved fluorescence spectroscopy. The primary aim of the work is to determine the protein (BSA) quantization by fluorescence enhancement method and investigate the 'enhancer' activity of crown ether (CW) on it to increase the resolution. Steady state and time resolved fluorescence measurements demonstrated how fluorescence intensity of ATA could be used for the determination of the protein BSA in aqueous solution. The binding of dye (probe/fluorescent medicinal molecule) with protein and the denaturing effect in the polar environment of acetonitrile of the dye protein complex act as drug binding as well as drug release activity. Apart from its basic research point of view, the present study also possesses significant importance and applications in the field of medicinal chemistry. Copyright © 2011 Elsevier B.V. All rights reserved.

Salutary effect of Aurintricarboxylic acid (ATA) on endotoxin- and sepsis-induced changes in muscle protein synthesis and inflammation

PubMed Central

Laufenberg, Lacee; Kazi, Abid A.; Lang, Charles H.

2014-01-01

Small molecule nonpeptidyl molecules are potentially attractive drug candidates as adjunct therapies in the treatment of sepsis-induced metabolic complications. As such, the current study investigates the use of aurintricarboxylic acid (ATA), which stimulates insulin-like growth factor (IGF)-I receptor and AKT signaling, for its ability to ameliorate the protein metabolic effects of endotoxin (LPS) + interferon (IFN)γ in C2C12 myotubes and sepsis in skeletal muscle. ATA dose- and time-dependently increases mTOR-dependent protein synthesis. Pretreatment with ATA prevents the LPS/IFNγ-induced decrease in protein synthesis at least in part by maintaining mTOR kinase activity, while post-treatment with ATA is able to increase protein synthesis when added up to 6 h after LPS/IFNγ. ATA also reverses the amino acid resistance which is detected in response to nutrient deprivation. Conversely, ATA decreases the basal rate of protein degradation and prevents the LPS/IFNγ-increase in proteolysis, and the latter change is associated reduced atrogin-1 and MuRF1 mRNA. The ability of ATA to antagonize LPS/IFNγ-induced changes in protein metabolism were associated with its ability to prevent the increases in IL-6 and NOS2 and decreases in IGF-I. In vivo studies indicate ATA acutely increases skeletal muscle, but not cardiac, protein synthesis, and attenuates the loss of lean body mass over 5 days. These data suggest ATA and other small molecule agonists of endogenous anabolic hormones may prove beneficial in treating sepsis by decreasing the inflammatory response and improving muscle protein balance. PMID:24430547

Revascularization of the upper posterior circulation with the anterior temporal artery: an anatomical feasibility study.

PubMed

Tayebi Meybodi, Ali; Lawton, Michael T; Griswold, Dylan; Mokhtari, Pooneh; Payman, Andre; Tabani, Halima; Yousef, Sonia; Benet, Arnau

2017-09-22

OBJECTIVE In various disease processes, including unclippable aneurysms, a bypass to the upper posterior circulation (UPC) including the superior cerebellar artery (SCA) and posterior cerebral artery (PCA) may be needed. Various revascularization options exist, but the role of intracranial (IC) donors has not been scrutinized. The objective of this study was to evaluate the anatomical feasibility of utilizing the anterior temporal artery (ATA) for revascularization of the UPC. METHODS ATA-SCA and ATA-PCA bypasses were performed on 14 cadaver specimens. After performing an orbitozygomatic craniotomy and opening the basal cisterns, the ATA was divided at the M 3 -M 4 junction and mobilized to the crural cistern to complete an end-to-side bypass to the SCA and PCA. The length of the recipient artery between the anastomosis and origin was measured. RESULTS Seventeen ATAs were found. Successful anastomosis was performed in 14 (82%) of the ATAs. The anastomosis point on the PCA was 14.2 mm from its origin on the basilar artery. The SCA anastomosis point was 10.1 mm from its origin. Three ATAs did not reach the UPC region due to a common opercular origin with the middle temporal artery. The ATA-SCA bypass was also applied to the management of an incompletely coiled SCA aneurysm. CONCLUSIONS The ATA is a promising IC donor for UPC revascularization. The ATA is exposed en route to the proximal SCA and PCA through the pterional-orbitozygomatic approach. Also, the end-to-side anastomosis provides an efficient and straightforward bypass without the need to harvest a graft or perform multiple or difficult anastomoses.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pierson, Bob; Laughlin, Darren

Under this Department of Energy (DOE) grant, A-Tech Corporation d.b.a. Applied Technology Associates (ATA), seeks to develop a seven-degree-of-freedom (7-DOF) seismic measurement tool for high-temperature geothermal applications. The Rotational-Enabled 7-DOF Seismometer includes a conventional tri-axial accelerometer, a conventional pressure sensor or hydrophone, and a tri-axial rotational sensor. The rotational sensing capability is novel, based upon ATA's innovative research in rotational sensing technologies. The geothermal industry requires tools for high-precision seismic monitoring of crack formation associated with Enhanced Geothermal System (EGS) stimulation activity. Currently, microseismic monitoring is conducted by deploying many seismic tools at different depth levels along a 'string' withinmore » drilled observation wells. Costs per string can be hundreds of thousands of dollars. Processing data from the spatial arrays of linear seismometers allows back-projection of seismic wave states. In contrast, a Rotational-Enabled 7-DOF Seismometer would simultaneously measure p-wave velocity, s-wave velocity, and incident seismic wave direction all from a single point measurement. In addition, the Rotational-Enabled 7-DOF Seismometer will, by its nature, separate p- and s-waves into different data streams, simplifying signal processing and facilitating analysis of seismic source signatures and geological characterization. By adding measurements of three additional degrees-of-freedom at each level and leveraging the information from this new seismic observable, it is likely that an equally accurate picture of subsurface seismic activity could be garnered with fewer levels per hole. The key cost savings would come from better siting of the well due to increased information content and a decrease in the number of confirmation wells drilled, also due to the increase in information per well. Improved seismic tools may also increase knowledge, understanding, and confidence, thus removing some current blocks to feasibility and significantly increasing access to potential geothermal sites. During the Phase 1 effort summarized in this final report, the ATA Team modeled and built two TRL 3 proof-of-concept test units for two competing rotational sensor technologies. The two competing technologies were based on ATA's angular rate and angular displacement measurement technologies; Angular rate: ATA's Magnetohydrodynamic Angular Rate Sensor (Seismic MHD); and Angular displacement: ATA's Low Frequency Improved Torsional Seismometer (LFITS). In order to down-select between these two technologies and formulate a go / no go decision, the ATA Team analyzed and traded scientific performance requirements and market constraints against sensor characteristics and components, acquiring field data where possible to validate the approach and publishing results from these studies of rotational technology capability. Based on the results of Phase 1, the ATA Team finds that the Seismic MHD (SMHD) technology is the best choice for enabling rotational seismometry and significant technical potential exists for micro-seismic monitoring using a downhole 7-DOF device based on the SMHD. Recent technical papers and field data confirm the potential of rotational sensing for seismic mapping, increasing confidence that cost-reduction benefits are achievable for EGS. However, the market for geothermal rotational sensing is small and undeveloped. As a result, this report recommends modifying the Phase 2 plan to focus on prototype development aimed at partnering with early adopters within the geothermal industry and the scientific research community. The highest public benefit will come from development and deployment of a science-grade SMHD rotational seismometer engineered for geothermal downhole conditions and an integrated test tool for downhole measurements at active geothermal test sites.« less

Pulmonary tolerance in man to continuous oxygen exposure at 3.0, 2.5, 2.0, and 1.5 ATA in Predictive Studies V

NASA Technical Reports Server (NTRS)

Clark, J. M.; Gelfand, R.; Flores, N. D.; Lambertsen, C. J.; Pisarello, J. B.

1987-01-01

Oxygen effects on pulmonary function were measured in normal, resting men who breathed oxygen continuously at 3.0, 2.5, 2.0, and 1.5 ATA to predefined limits of CNS, cardiac, or pulmonary tolerance. Rates of pulmonary symptom intensification and decrease in vital capacity (VC) increased progressively with elevation of inspired oxygen pressure. Although VC decrements occurred concurrently with symptoms, the lung volume changes became prominent when symptoms were still mild. The observed effects were consistent with the interpretation that small airway function is impaired more selectively by oxygen exposure at 3.0 and 2.5 ATA than by exposure at 2.0 and 1.5 ATA. Despite similar VC changes after oxygen exposure at 2.0 ATA for nearly 10 hr and exposure at 1.5 ATA for almost 18 hr, the 2.0 ATA exposure caused greater impairment of pulmonary function and required a longer recovery period.

A simulator evaluation of an automatic terminal approach system

NASA Technical Reports Server (NTRS)

Hinton, D. A.

1983-01-01

The automatic terminal approach system (ATAS) is a concept for improving the pilot/machine interface with cockpit automation. The ATAS can automatically fly a published instrument approach by using stored instrument approach data to automatically tune airplane avionics, control the airplane's autopilot, and display status information to the pilot. A piloted simulation study was conducted to determine the feasibility of an ATAS, determine pilot acceptance, and examine pilot/ATAS interaction. Seven instrument-rated pilots each flew four instrument approaches with a base-line heading select autopilot mode. The ATAS runs resulted in lower flight technical error, lower pilot workload, and fewer blunders than with the baseline autopilot. The ATAS status display enabled the pilots to maintain situational awareness during the automatic approaches. The system was well accepted by the pilots.

Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association.

PubMed

Garber, Jeffrey R; Cobin, Rhoda H; Gharib, Hossein; Hennessey, James V; Klein, Irwin; Mechanick, Jeffrey I; Pessah-Pollack, Rachel; Singer, Peter A; Woeber, Kenneth A

2012-12-01

Hypothyroidism has multiple etiologies and manifestations. Appropriate treatment requires an accurate diagnosis and is influenced by coexisting medical conditions. This paper describes evidence-based clinical guidelines for the clinical management of hypothyroidism in ambulatory patients. The development of these guidelines was commissioned by the American Association of Clinical Endocrinologists (AACE) in association with American Thyroid Association (ATA). AACE and the ATA assembled a task force of expert clinicians who authored this article. The authors examined relevant literature and took an evidence-based medicine approach that incorporated their knowledge and experience to develop a series of specific recommendations and the rationale for these recommendations. The strength of the recommendations and the quality of evidence supporting each was rated according to the approach outlined in the American Association of Clinical Endocrinologists Protocol for Standardized Production of Clinical Guidelines-2010 update. Topics addressed include the etiology, epidemiology, clinical and laboratory evaluation, management, and consequences of hypothyroidism. Screening, treatment of subclinical hypothyroidism, pregnancy, and areas for future research are also covered. Fifty-two evidence-based recommendations and subrecommendations were developed to aid in the care of patients with hypothyroidism and to share what the authors believe is current, rational, and optimal medical practice for the diagnosis and care of hypothyroidism. A serum thyrotropin is the single best screening test for primary thyroid dysfunction for the vast majority of outpatient clinical situations. The standard treatment is replacement with L-thyroxine. The decision to treat subclinical hypothyroidism when the serum thyrotropin is less than 10 mIU/L should be tailored to the individual patient.

Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association.

PubMed

Garber, Jeffrey R; Cobin, Rhoda H; Gharib, Hossein; Hennessey, James V; Klein, Irwin; Mechanick, Jeffrey I; Pessah-Pollack, Rachel; Singer, Peter A; Woeber, Kenneth A

2012-01-01

Hypothyroidism has multiple etiologies and manifestations. Appropriate treatment requires an accurate diagnosis and is influenced by coexisting medical conditions. This paper describes evidence-based clinical guidelines for the clinical management of hypothyroidism in ambulatory patients. The development of these guidelines was commissioned by the American Association of Clinical Endocrinologists (AACE) in association with American Thyroid Association (ATA). AACE and the ATA assembled a task force of expert clinicians who authored this article. The authors examined relevant literature and took an evidence-based medicine approach that incorporated their knowledge and experience to develop a series of specific recommendations and the rationale for these recommendations. The strength of the recommendations and the quality of evidence supporting each was rated according to the approach outlined in the American Association of Clinical Endocrinologists Protocol for Standardized Production of Clinical Guidelines-2010 update. Topics addressed include the etiology, epidemiology, clinical and laboratory evaluation, management, and consequences of hypothyroidism. Screening, treatment of subclinical hypothyroidism, pregnancy, and areas for future research are also covered. Fifty-two evidence-based recommendations and subrecommendations were developed to aid in the care of patients with hypothyroidism and to share what the authors believe is current, rational, and optimal medical practice for the diagnosis and care of hypothyroidism. A serum thyrotropin is the single best screening test for primary thyroid dysfunction for the vast majority of outpatient clinical situations. The standard treatment is replacement with L-thyroxine. The decision to treat subclinical hypothyroidism when the serum thyrotropin is less than 10 mIU/L should be tailored to the individual patient.

The anterior temporal artery: an underutilized but robust donor for revascularization of the distal middle cerebral artery.

PubMed

Tayebi Meybodi, Ali; Lawton, Michael T; Griswold, Dylan; Mokhtari, Pooneh; Payman, Andre; Benet, Arnau

2017-10-01

OBJECTIVE The anterior temporal artery (ATA) supplies an area of the brain that, if sacrificed, does not cause a noticeable loss of function. Therefore, the ATA may be used as a donor in intracranial-intracranial (IC-IC) bypass procedures. The capacities of the ATA as a donor have not been studied previously. In this study, the authors assessed the feasibility of using the ATA as a donor for revascularization of different segments of the distal middle cerebral artery (MCA). METHODS The ATA was studied in 15 cadaveric specimens (8 heads, excluding 1 side). First, the cisternal segment of the artery was untethered from arachnoid adhesions and small branches feeding the anterior temporal lobe and insular cortex, to evaluate its capacity for a side-to-side bypass to insular, opercular, and cortical segments of the MCA. Any branch entering the anterior perforated substance was preserved. Then, the ATA was cut at the opercular-cortical junction and the capacity for an end-to-side bypass was assessed. RESULTS From a total of 17 ATAs, 4 (23.5%) arose as an early MCA branch. The anterior insular zone and the frontal parasylvian cortical arteries were the best targets (in terms of mobility and caliber match) for a side-to-side bypass. Most of the insula was accessible for end-to-side bypass, but anterior zones of the insula were more accessible than posterior zones. End-to-side bypass was feasible for most recipient cortical arteries along the opercula, except for posterior temporal and parietal regions. Early ATAs reached significantly farther on the insular MCA recipients than non-early ATAs for both side-to-side and end-to-side bypasses. CONCLUSIONS The ATA is a robust arterial donor for IC-IC bypass procedures, including side-to-side and end-to-side techniques. The evidence provided in this work supports the use of the ATA as a donor for distal MCA revascularization in well-selected patients.

The effect of hyperbaric oxygen treatment on early regeneration of sensory axons after nerve crush in the rat.

PubMed

Bajrović, Fajko F; Sketelj, Janez; Jug, Marko; Gril, Iztok; Mekjavić, Igor B

2002-09-01

Abstract The effect of hyperbaric oxygen treatment (HBO) on sensory axon regeneration was examined in the rat. The sciatic nerve was crushed in both legs. In addition, the distal stump of the sural nerve on one side was made acellular and its blood perfusion was compromised by freezing and thawing. Two experimental groups received hyperbaric exposures (2.5 ATA) to either compressed air (pO2 = 0.5 ATA) or 100% oxygen (pO2 = 2.5 ATA) 90 minutes per day for 6 days. Sensory axon regeneration in the sural nerve was thereafter assessed by the nerve pinch test and immunohistochemical reaction to neurofilament. HBO treatment increased the distances reached by the fastest regenerating sensory axons by about 15% in the distal nerve segments with preserved and with compromised blood perfusion. There was no significant difference between the rats treated with different oxygen tensions. The total number of regenerated axons in the distal sural nerve segments after a simple crush injury was not affected, whereas in the nerve segments with compromised blood perfusion treated by the higher pO2, the axon number was about 30% lower than that in the control group. It is concluded that the beneficial effect of HBO on sensory axon regeneration is not dose-dependent between 0.5 and 2.5 ATA pO2. Although the exposure to 2.5 ATA of pO2 moderately enhanced early regeneration of the fastest sensory axons, it decreased the number of regenerating axons in the injured nerves with compromised blood perfusion of the distal nerve stump.

Alteration of striatal dopamine levels under various partial pressure of oxygen in pre-convulsive and convulsive phases in freely-moving rats.

PubMed

Lavoute, Cécile; Weiss, Michel; Risso, Jean-Jacques; Rostain, Jean-Claude

2014-02-01

The purpose of this study was to investigate the change in the striatal dopamine (DA) level in freely-moving rat exposed to different partial pressure of oxygen (from 1 to 5 ATA). Some works have suggested that DA release by the substantia nigra pars compacta (SNc) neurons in the striatum could be disturbed by hyperbaric oxygen (HBO) exposure, altering therefore the basal ganglia activity. Such changes could result in a change in glutamatergic and GABAergic control of the dopaminergic neurons into the SNc. Such alterations could provide more information about the oxygen-induced seizures observed at 5 ATA in rat. DA-sensitive electrodes were implanted into the striatum under general anesthesia. After 1 week rest, awaked rats were exposed to oxygen-nitrogen mixture at a partial pressure of oxygen of 1, 2, 3, 4 and 5 ATA. DA level was monitored continuously (every 3 min) by in vivo voltammetry before and during HBO exposure. HBO induced a decrease in DA level in relationship to the increase in partial pressure of oxygen from 1 ATA to 4 ATA (-15 % at 1 ATA, -30 % at 2 ATA, -40 % at 3 ATA, -45 % at 4 ATA), without signs of oxygen toxicity. At 5 ATA, DA level strongly decreases (-75 %) before seizure which occurred after 27 min ± 7 HBO exposure. After the epileptic seizure the decrease in DA level disappeared. These changes and the biphasic effect of HBO were discussed in function of HBO action on neurochemical regulations of the nigro striatal pathway.

Special Operations Forces Interagency Counterterrorism Reference Manual, Second Edition

DTIC Science & Technology

2011-04-01

identify, interdict, and defeat terrorists. The Antiterrorism Assistance Program ( ATA ), implemented by the DS and discussed later (page 1-12), is...the Federal Bureau of Investigation. Antiterrorism Assistance Program ( ATA ) www.state.gov/m/ds/terrorism/c8583.htm The ATA is managed by the Office...scene investigation, airport and building secu- rity, maritime protection measures, and VIP protec- tion. More broadly, ATA seek to increase capacity to

Survey on Safety Incentive Plans

DOT National Transportation Integrated Search

1951-10-01

The Administrative Committee of the ATA Small Operations Division, with the assistance of the ATA Department of Personnel and Accident Prevention, is sponsoring a series of related compilations, based upon brief surveys among ATA member companies tha...

Interaction of aurintricarboxylic acid (ATA) with four nucleic acid binding proteins DNase I, RNase A, reverse transcriptase and Taq polymerase

NASA Astrophysics Data System (ADS)

Ghosh, Utpal; Giri, Kalyan; Bhattacharyya, Nitai P.

2009-12-01

In the investigation of interaction of aurintricarboxylic acid (ATA) with four biologically important proteins we observed inhibition of enzymatic activity of DNase I, RNase A, M-MLV reverse transcriptase and Taq polymerase by ATA in vitro assay. As the telomerase reverse transcriptase (TERT) is the main catalytic subunit of telomerase holoenzyme, we also monitored effect of ATA on telomerase activity in vivo and observed dose-dependent inhibition of telomerase activity in Chinese hamster V79 cells treated with ATA. Direct association of ATA with DNase I ( Kd = 9.019 μM)), RNase A ( Kd = 2.33 μM) reverse transcriptase ( Kd = 0.255 μM) and Taq polymerase ( Kd = 81.97 μM) was further shown by tryptophan fluorescence quenching studies. Such association altered the three-dimensional conformation of DNase I, RNase A and Taq polymerase as detected by circular dichroism. We propose ATA inhibits enzymatic activity of the four proteins through interfering with DNA or RNA binding to the respective proteins either competitively or allosterically, i.e. by perturbing three-dimensional structure of enzymes.

A simulation evaluation of a pilot interface with an automatic terminal approach system

NASA Technical Reports Server (NTRS)

Hinton, David A.

1987-01-01

The pilot-machine interface with cockpit automation is a critical factor in achieving the benefits of automation and reducing pilot blunders. To improve this interface, an automatic terminal approach system (ATAS) was conceived that can automatically fly a published instrument approach by using stored instrument approach data to automatically tune airplane radios and control an airplane autopilot and autothrottle. The emphasis in the ATAS concept is a reduction in pilot blunders and work load by improving the pilot-automation interface. A research prototype of an ATAS was developed and installed in the Langley General Aviation Simulator. A piloted simulation study of the ATAS concept showed fewer pilot blunders, but no significant change in work load, when compared with a baseline heading-select autopilot mode. With the baseline autopilot, pilot blunders tended to involve loss of navigational situational awareness or instrument misinterpretation. With the ATAS, pilot blunders tended to involve a lack of awareness of the current ATAS mode state or deficiencies in the pilots' mental model of how the system operated. The ATAS display provided adequate approach status data to maintain situational awareness.

Inhibitory Activity of Iron Chelators ATA and DFO on MCF-7 Breast Cancer Cells and Phosphatases PTP1B and SHP2.

PubMed

Kuban-Jankowska, Alicja; Sahu, Kamlesh K; Gorska-Ponikowska, Magdalena; Tuszynski, Jack A; Wozniak, Michal

2017-09-01

Rapidly-dividing cancer cells have higher requirement for iron compared to non-transformed cells, making iron chelating a potential anticancer strategy. In the present study we compared the anticancer activity of uncommon iron chelator aurintricarboxylic acid (ATA) with the known deferoxamine (DFO). We investigated the impact of ATA and DFO on the viability and proliferation of MCF-7 cancer cells. Moreover we performed enzymatic activity assays and computational analysis of the ATA and DFO effects on pro-oncogenic phosphatases PTP1B and SHP2. ATA and DFO decrease the viability and proliferation of breast cancer cells, but only ATA considerably reduces the activity of PTP1B and SHP2 phosphatases. Our studies indicated that ATA strongly inactivates and binds in the PTP1B and SHP2 active site, interacting with arginine residue essential for enzyme activity. We confirmed that iron chelating can be considered as a potential strategy for the adjunctive treatment of breast cancer. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Effects on respiratory homeostasis of prolonged, continuous hyperoxia at 1.5 to 3.0 ATA in man in Predictive Studies V

NASA Technical Reports Server (NTRS)

Gelfand, R.; Clark, J. M.; Lambertsen, C. J.; Pisarello, J. B.

1987-01-01

Prolonged exposures of men to continuous hyperoxia at 3.0, 2.5, 2.0, and 1.5 ATA were conducted to define CNS oxygen tolerance and to investigate the effects of prolonged hyperoxia on CNS and other organ functions. Altered respiratory homeostasis was evident during exposures of men to 2.5 and 3.0 ATA O2 as nonprogressive increment in ventilation and reciprocal decrement in PET(CO2). These changes were progressive during exposure at 1.5 ATA O2. Mean values of respiratory reactivity at CO2 were somewhat increased following prolonged hyperoxia at 1.5 and 2.5 ATA, compared to preexposure mean values. Hypoxic ventilatory response was unchanged or enhanced after oxygen exposures at 1.5 and 2.5 ATA. Observed respiratory and body temperature changes were not of sufficient magnitude to impair function.

A Low-Cost, Passive Approach for Bacterial Growth and Distribution for Large-Scale Implementation of Bioaugmentation

DTIC Science & Technology

2010-12-01

l layout, a t racer test was conducted t o ve rify the gr oundwater hydraulic c onditions i n t he t reatment c ells. D ata c ollected i n s upport...no t expe cted to affect d ata interpretation for the E R-0513 demonstration be cause future bi odegradation would cause further f ractionation of...DHC bacteria (as m easured by qPCR analysis) a t a gi ving m onitoring l ocation f ollowing i noculation. T his travel t ime was then compared to the

Redox process is crucial for inhibitory properties of aurintricarboxylic acid against activity of YopH: virulence factor of Yersinia pestis

PubMed Central

Kuban-Jankowska, Alicja; Gorska, Magdalena; Tuszynski, Jack A; Ossowski, Tadeusz; Wozniak, Michal

2015-01-01

YopH is a bacterial protein tyrosine phosphatase, which is essential for the viability and pathogenic virulence of the plague-causing Yersinia sp. bacteria. Inactivation of YopH activity would lead to the loss of bacterial pathogenicity. We have studied the inhibitory properties of aurintricarboxylic acid (ATA) against YopH phosphatase and found that at nanomolar concentrations ATA reversibly decreases the activity of YopH. Computational docking studies indicated that in all binding poses ATA binds in the YopH active site. Molecular dynamics simulations showed that in the predicted binding pose, ATA binds to the essential Cys403 and Arg409 residues in the active site and has a stronger binding affinity than the natural substrate (pTyr). The cyclic voltammetry experiments suggest that ATA reacts remarkably strongly with molecular oxygen. Additionally, the electrochemical reduction of ATA in the presence of a negative potential from −2.0 to 2.5 V generates a current signal, which is observed for hydrogen peroxide. Here we showed that ATA indicates a unique mechanism of YopH inactivation due to a redox process. We proposed that the potent inhibitory properties of ATA are a result of its strong binding in the YopH active site and in situ generation of hydrogen peroxide near catalytic cysteine residue. PMID:26286963

Key features for ATA / ATR database design in missile systems

NASA Astrophysics Data System (ADS)

Özertem, Kemal Arda

2017-05-01

Automatic target acquisition (ATA) and automatic target recognition (ATR) are two vital tasks for missile systems, and having a robust detection and recognition algorithm is crucial for overall system performance. In order to have a robust target detection and recognition algorithm, an extensive image database is required. Automatic target recognition algorithms use the database of images in training and testing steps of algorithm. This directly affects the recognition performance, since the training accuracy is driven by the quality of the image database. In addition, the performance of an automatic target detection algorithm can be measured effectively by using an image database. There are two main ways for designing an ATA / ATR database. The first and easy way is by using a scene generator. A scene generator can model the objects by considering its material information, the atmospheric conditions, detector type and the territory. Designing image database by using a scene generator is inexpensive and it allows creating many different scenarios quickly and easily. However the major drawback of using a scene generator is its low fidelity, since the images are created virtually. The second and difficult way is designing it using real-world images. Designing image database with real-world images is a lot more costly and time consuming; however it offers high fidelity, which is critical for missile algorithms. In this paper, critical concepts in ATA / ATR database design with real-world images are discussed. Each concept is discussed in the perspective of ATA and ATR separately. For the implementation stage, some possible solutions and trade-offs for creating the database are proposed, and all proposed approaches are compared to each other with regards to their pros and cons.

Investigations on the interactions of aurintricarboxylic acid with bovine serum albumin: Steady state/time resolved spectroscopic and docking studies.

PubMed

Bardhan, Munmun; Chowdhury, Joydeep; Ganguly, Tapan

2011-01-10

In this paper, the nature of the interactions between bovine serum albumin (BSA) and aurintricarboxylic acid (ATA) has been investigated by measuring steady state and time-resolved fluorescence, circular dichroism (CD), FT-IR and fluorescence anisotropy in protein environment under physiological conditions. From the analysis of the steady state and time-resolved fluorescence quenching of BSA in aqueous solution in presence of ATA it has been inferred that the nature of the quenching originates from the combined effect of static and dynamic modes. From the determination of the thermodynamic parameters obtained from temperature-dependent changes in K(b) (binding constant) it was apparent that the combined effect of hydrophobic association and electrostatic attraction is responsible for the interaction of ATA with BSA. The effect of ATA on the conformation of BSA has been examined by analyzing CD spectrum. Though the observed results demonstrate some conformational changes in BSA in presence of ATA but the secondary structure of BSA, predominantly of α-helix, is found to retain its identity. Molecular docking of ATA with BSA also indicates that ATA docks through hydrophobic interaction. Copyright © 2010 Elsevier B.V. All rights reserved.

Effects of hyperbaric oxygen therapy in enhancing expressions of e-NOS, TNF-α and VEGF in wound healing

NASA Astrophysics Data System (ADS)

Susilo, Imam; Devi, Anita; Purwandhono, Azham; Hadi Warsito, Sunaryo

2017-05-01

Wound healing is a physiological process that occurs progressively through overlapping phases. Tissue oxygenation is an important part of the complex regulation for wound healing. Hyperbaric Oxygen (HBO) therapy is a method of increasing oxygen delivery to tissues. The therapy improves tissue oxygenation and stimulates the formation of H2O2 as a secondary messenger for Tumour Necrosis Factor alpha (TNF α), e-NOS, VEGF and Nuclear Factor Kappa Beta phosphorylation (NF-Kb) which play an important role in the rapid transcription of a wide variety of genes in response to extracellular stimuli. This study aims to determine the effects of Hyperbaric Oxygen therapy in enhancing the expressions of e-NOS, TNF-α, VEGF and wound healing. This study is an animal study with a ‘randomized control group of pre-test and post test design’ on 28 Wistar rats. Randomly, the rats were divided into 4 groups with 7 rats in each group. The HBO treatment group 1 received 5 sessions of HBO 2.4 ATA in 3 × 30 minutes; the HBO treatment group 2 received 10 sessions of HBO 2.4 ATA in 3 × 30 minutes; and each of the control groups were without HBO. Each of the 28 male rats were given a full thickness excisional wound of 1 × 1cm. Examinations of e-NOS, TNF-α, VEGF expressions and wound healing were performed on day-0 (pre-HBO) and day-5 HBO or on day-0 (pre-HBO) and day-10 HBO. The resultsshowthat the Hyperbaric Oxygen therapy can improve e-NOS (p=0.02), TNF-α (p= 0.02), VEGF expression (p=0.02) and wound healing (p=0.002) significantly in the provision of HBO 2.4 ATA for 3 × 30 minutes in 5 sessions over 5 consecutive days. While the 10 sessions of HBO 2.4 ATA for 3 × 30 minutes over 10 consecutive days only increase e-NOS (p=0.02), TNF-α (p=0.04), VEGF expression significantly (p=0.03) but do not improve wound healing significantly (p=0.3) compared with no HBO. The study concludes that HBO can improve the expressions of e-NOS, TNF-α, VEGF and wound healing in the provision of HBO 2.4 ATA for 3 × 30 minutes in 5 sessions, while the 10 sessions of HBO 2.4 ATA for 3 × 30 minutes only increase e-NOS, TNF-α, VEGF expression but do not improve wound healing.

Regulatory pathways to enable the licencing of alternatives to antibiotics.

PubMed

Ioannou, Faye; Burnsteel, Cindy; Mackay, David K J; Gay, Cyril G

2018-05-01

Effective alternatives to antibiotics (ATA) such as vaccines, antibodies, phage therapies, prebiotics, probiotics and herbal medicines can be used in place of traditional antibiotics in a way that does not compromise animal health as means of tackling the growing threat to both animal and human health from antimicrobial resistance (AMR). This paper reflects the key points on the approaches that were discussed during the 2nd International Symposium on ATA between regulatory agencies, veterinary product companies representing largely the pharmaceutical and feed-additive sectors, academia and other stakeholders on regulatory pathways to enable the licensing of alternatives to antibiotics for food producing animals. The need to demonstrate compliance with generally accepted standards for quality, safety and efficacy is considered a pre-requisite for all veterinary medicinal products receiving an authorisation including ATA, irrespective of the region in which they are approved. ATA are often based on novel technologies, with complex mechanisms of action; therefore, early and close communication with regulators is encouraged. In addition, strategic use by ATA applicants of all regulatory tools available to support innovation is highly recommended. The veterinary product manufacturers consider that the regulation of veterinary medicines should evolve to accommodate innovative ATA technologies and incentives from regulatory agencies provided to stimulate further ATA development. Copyright © 2018.

Utilization of the American Telemedicine Association's Clinical Practice Guidelines

PubMed Central

Antoniotti, Nina; Bernard, Jordana

2013-01-01

Abstract Background: The American Telemedicine Association (ATA) Standards and Guidelines Committee develops practice standards and guidelines. Key to the Committee's mission is dissemination so the standards can be used in the practice of telemedicine. Over a 2-year period, when a standards document was accessed from the ATA Web site, a short survey was completed, but it did not assess how the documents were used once downloaded. A more formal survey was conducted to determine the impact ATA standards and guidelines are having on healthcare delivery via telemedicine. Materials and Methods: A survey was developed and distributed via SurveyMonkey to 13,177 ATA members and nonmembers in November 2011. Results were compiled and analyzed after a 90-day open period for responses to be submitted. Results: The majority of respondents (96%) believe the practice of telemedicine/telehealth should have standards and guidelines and that the ATA and other professional societies/associations should be responsible for developing them. The top uses of guidelines include guidance for clinical practice, training, gaining reimbursement, and research. Respondents indicating a need for standards and guidelines said the ATA (78.7%) and other professional societies/associations (74.5%) should be responsible for development. When asked to list specific practice guidelines or standards they are using for telehealth, the majority (21.5%) are using in-house (e.g., hospital, company)-developed guidelines, followed by those from professional associations/societies (20.4%) and those developed by the ATA (18.2%). Conclusions: Overall, the survey results indicate guidelines documents developed by the ATA and other professional societies and those developed in-house are being regularly accessed and used in both public and private sectors. Practitioners of telemedicine believe that standards and guidelines are needed for guidance for clinical practice, training, gaining reimbursement, and research, and they are to use those developed by professional organization such as the ATA as well as those developed by their own institutions. PMID:24050615

Prospective Validation of ATA and ETA Sonographic Pattern Risk of Thyroid Nodules Selected for FNAC.

PubMed

Maino, Fabio; Forleo, Raffaella; Martinelli, Martina; Fralassi, Noemi; Barbato, Filomena; Pilli, Tania; Capezzone, Marco; Brilli, Lucia; Ciuoli, Cristina; Di Cairano, Giovanni; Nigi, Laura; Pacini, Furio; Castagna, Maria Grazia

2018-06-01

Recently, the American Thyroid Association (ATA) and the European Thyroid Association (ETA) have proposed that thyroid ultrasound (US) should be used to stratify the risk of malignancy in thyroid nodules and to aid decision-making about whether fine-needle aspiration cytology (FNAC) is indicated. To validate and to compare the ATA and ETA US risk stratification systems of thyroid nodules in a prospective series of thyroid nodules submitted to FNAC. We prospectively evaluated 432 thyroid nodules selected for FNAC from 340 patients. Cytology reports were based on the five categories according to the criteria of the British Thyroid Association. The proportion of Thy2 nodules decreased significantly, whereas the proportion of Thy4/Thy5 nodules significantly increased with increasing US risk class (P < 0.0001). The ability to identify benign and malignant nodules was similar between ATA and ETA systems. According to ATA and ETA US risk stratification systems, 23.7% and 56.0% nodules did not meet the criteria for FNAC, respectively. Considering only categories at lower risk of malignancy, the cumulative malignancy rate in these nodules was 1.2% for ATA and 1.7% for ETA US risk stratification systems. ETA and ATA US risk stratification systems provide effective malignancy risk stratification for thyroid nodules. In clinical practice, using this approach, we should be able to reduce the number of unnecessary FNAC without losing clinically relevant thyroid cancer.

Estimation of ligament strains and joint moments in the ankle during a supination sprain injury.

PubMed

Wei, Feng; Fong, Daniel Tik-Pui; Chan, Kai-Ming; Haut, Roger C

2015-01-01

This study presents the ankle ligament strains and ankle joint moments during an accidental injury event diagnosed as a grade I anterior talofibular ligament (ATaFL) sprain. A male athlete accidentally sprained his ankle while performing a cutting motion in a laboratory setting. The kinematic data were input to a three-dimensional rigid-body foot model for simulation analyses. Maximum strains in 20 ligaments were evaluated in simulations that investigated various combinations of the reported ankle joint motions. Temporal strains in the ATaFL and the calcaneofibular ligament (CaFL) were then compared and the three-dimensional ankle joint moments were evaluated from the model. The ATaFL and CaFL were highly strained when the inversion motion was simulated (10% for ATaFL and 12% for CaFL). These ligament strains were increased significantly when either or both plantarflexion and internal rotation motions were added in a temporal fashion (up to 20% for ATaFL and 16% for CaFL). Interestingly, at the time strain peaked in the ATaFL, the plantarflexion angle was not large but apparently important. This computational simulation study suggested that an inversion moment of approximately 23 N m plus an internal rotation moment of approximately 11 N m and a small plantarflexion moment may have generated a strain of 15-20% in the ATaFL to produce a grade I ligament injury in the athlete's ankle. This injury simulation study exhibited the potentially important roles of plantarflexion and internal rotation, when combined with a large inversion motion, to produce a grade I ATaFL injury in the ankle of this athlete.

Being a victim or an aggressor: Different functions of triadic post-conflict interactions in wolves (Canis lupus lupus).

PubMed

Cordoni, Giada; Palagi, Elisabetta

2015-01-01

Animals adopt different behavioral strategies to cope with the conflict of interests coming from the competition over limited resources. Starting from the study on chimpanzees, post-conflict third-party affiliation (the affiliative contact provided by a third-party toward the victim--VTA--or the aggressor--ATA) was investigated mainly in primates. Later, this post-conflict mechanism has been demonstrated also in other mammals, such as wallabies, horses, dolphins, domestic dogs, and wolves. Here, we present data on triadic post-conflict affiliation in wolves (Canis lupus lupus) by exploring some of the hypotheses already proposed for primates and never tested before in other social mammals. In this carnivore species, the study of VTA and ATA revealed that these strategies cannot be considered as a unique behavioral category since they differ in many functional aspects. VTA serves to protect the victim by reducing the likelihood of reiterated attacks from the previous aggressor and to reinforce the relationship shared by the third-party and the victim. On the other hand, ATA has a role in bystander protection by limiting the renewed attacks of the previous aggressor toward uninvolved group-members (potential third-parties). In conclusion, exploring VTA and ATA gives the opportunity to concurrently demonstrate some functional differences in triadic post-conflict affiliation according to the different targets of bystanders (victims or aggressors). The data comparison between primates and other social mammals should permit to open new lines of research. © 2015 Wiley Periodicals, Inc.

The Line Operations Safety Audit Program: Transitioning From Flight Operations to Maintenance and Ramp Operations

DTIC Science & Technology

2011-09-01

Transport Association ( ATA ) Maintenance & Ramp Human Factors Task Force committee members—we are deeply grateful for their contributions in the...6 Air Transport Association ( ATA ) Human Factors Task Force . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Form Development...garnered many valuable les- sons, safety improvements, and significant returns on their investment. 1The FAA ATA Human Factors Taskforce has

The Cultural Implications of Primary Health Care and the Declaration of Alma-Ata: The Health District of Kedougou, Senegal

ERIC Educational Resources Information Center

Blanas, Demetri A.

2008-01-01

In 1978, the World Health Organization (WHO) and the international health community convoked a conference in Alma-Ata, Kazakhstan, to address global inequalities in health. The conference resulted in the publication of the "Declaration of Alma-Ata," which made the ambitious call "for urgent action by all governments, all health and…

A Review of Fast L(1)-Minimization Algorithms for Robust Face Recognition

DTIC Science & Technology

2010-07-01

14) can be rewritten in the standard QP form as min Q(z) . = cTz + 12z TBz subj. to z ≥ 0, (15) where z = [x+;x−], c = λ1 + [−AT b;AT b], and B = [ ATA ... ATA − ATA ATA ] . (16) We note that the gradient of Q(z) is defined as ∇zQ(z) = c +Bz. (17) 5 A MATLAB implementation of GPSR is available at http...necessarily smooth nor convex. For `1-min in particular, g is also separable, that is, g(x) = n∑ i=1 gi (xi). (36) Clearly, let f(x) = 12‖b − Ax‖ 2 2 and

Association of Interleukin 23 Receptor Polymorphisms with Anti-Topoisomerase-I Positivity and Pulmonary Hypertension in Systemic Sclerosis

PubMed Central

AGARWAL, SANDEEP K.; GOURH, PRAVITT; SHETE, SANJAY; PAZ, GENE; DIVECHA, DIPAL; REVEILLE, JOHN D.; ASSASSI, SHERVIN; TAN, FILEMON K.; MAYES, MAUREEN D.; ARNETT, FRANK C.

2010-01-01

Objective IL23R has been identified as a susceptibility gene for development of multiple autoimmune diseases. We investigated the possible association of IL23R with systemic sclerosis (SSc), an autoimmune disease that leads to the development of cutaneous and visceral fibrosis. Methods We tested 9 single-nucleotide polymorphisms (SNP) in IL23R for association with SSc in a cohort of 1402 SSc cases and 1038 controls. IL23R SNP tested were previously identified as SNP showing associations with inflammatory bowel disease. Results Case-control comparisons revealed no statistically significant differences between patients and healthy controls with any of the IL23R polymorphisms. Analyses of subsets of SSc patients showed that rs11209026 (Arg381Gln variant) was associated with anti-topoisomerase I antibody (ATA)-positive SSc (p = 0.001)) and rs11465804 SNP was associated with diffuse and ATA-positive SSc (p = 0.0001, p = 0.0026, respectively). These associations remained significant after accounting for multiple comparisons using the false discovery rate method. Wild-type genotype at both rs11209026 and rs11465804 showed significant protection against the presence of pulmonary hypertension (PHT). (p = 3×10−5, p = 1×10−5, respectively). Conclusion Polymorphisms in IL23R are associated with susceptibility to ATA-positive SSc and protective against development of PHT in patients with SSc. PMID:19918037

A phase I study of low-pressure hyperbaric oxygen therapy for blast-induced post-concussion syndrome and post-traumatic stress disorder.

PubMed

Harch, Paul G; Andrews, Susan R; Fogarty, Edward F; Amen, Daniel; Pezzullo, John C; Lucarini, Juliette; Aubrey, Claire; Taylor, Derek V; Staab, Paul K; Van Meter, Keith W

2012-01-01

This is a preliminary report on the safety and efficacy of 1.5 ATA hyperbaric oxygen therapy (HBOT) in military subjects with chronic blast-induced mild to moderate traumatic brain injury (TBI)/post-concussion syndrome (PCS) and post-traumatic stress disorder (PTSD). Sixteen military subjects received 40 1.5 ATA/60 min HBOT sessions in 30 days. Symptoms, physical and neurological exams, SPECT brain imaging, and neuropsychological and psychological testing were completed before and within 1 week after treatment. Subjects experienced reversible middle ear barotrauma (5), transient deterioration in symptoms (4), and reversible bronchospasm (1); one subject withdrew. Post-treatment testing demonstrated significant improvement in: symptoms, neurological exam, full-scale IQ (+14.8 points; p<0.001), WMS IV Delayed Memory (p=0.026), WMS-IV Working Memory (p=0.003), Stroop Test (p<0.001), TOVA Impulsivity (p=0.041), TOVA Variability (p=0.045), Grooved Pegboard (p=0.028), PCS symptoms (Rivermead PCSQ: p=0.0002), PTSD symptoms (PCL-M: p<0.001), depression (PHQ-9: p<0.001), anxiety (GAD-7: p=0.007), quality of life (MPQoL: p=0.003), and self-report of percent of normal (p<0.001), SPECT coefficient of variation in all white matter and some gray matter ROIs after the first HBOT, and in half of white matter ROIs after 40 HBOT sessions, and SPECT statistical parametric mapping analysis (diffuse improvements in regional cerebral blood flow after 1 and 40 HBOT sessions). Forty 1.5 ATA HBOT sessions in 1 month was safe in a military cohort with chronic blast-induced PCS and PTSD. Significant improvements occurred in symptoms, abnormal physical exam findings, cognitive testing, and quality-of-life measurements, with concomitant significant improvements in SPECT.

Survival Analysis of Papillary Thyroid Carcinoma in Relation to Stage and Recurrence Risk: A 20-Year Experience in Pakistan.

PubMed

Hassan, Aamna; Razi, Mairah; Riaz, Saima; Khalid, Madeeha; Nawaz, M Khalid; Syed, Aamir Ali; Bashir, Humayun

2016-08-01

The aim of this study was to evaluate the overall and progression-free survival of papillary thyroid carcinoma (PTC), comparing the American Thyroid Association (ATA) guideline for risk of recurrence with the TNM staging system with dynamic assessment at 2 years. This study is a retrospective analysis of 689 PTC patients over a 20-year period at a single center. Disease-free survival based on the TNM staging and ATA recurrence risk was calculated using Kaplan-Meier curves. Dynamic response assessment during the first 2 years was compared for both systems. Survival was calculated based on age, baseline resectability, and postthyroidectomy serum tumor marker levels. Six hundred eighty-nine (72.2%) of the total thyroid cancer patients had PTC. Four hundred sixty-nine patients were females, and 220 patients were males. The age range was 6 to 87 years. Five hundred thirty-five patients were resectable, and 56 patients were unresectable. One hundred fifty-one patients were excluded due to insufficient information on recurrence risk. By ATA categorization, 39% had low risk, no disease-related mortality; 44% had intermediate risk, 3 died; and 17% had high risk, 32 died. The 5-year disease-free survival was 54%, 26%, and 5% in low-, intermediate-, and high-risk groups, respectively. The log-rank test showed a significant difference in the percent survival (P < 0.01). TNM stage wise, in terms of survival, 1.3% in stage I, 2.2% in stage II, 0% in stage III, and 37.5% in stage IV died. The 20-year disease-free survival showed the following: stage I, 43%; stage II, 28%; stage III, 18%; and stage IV, 2%. There is significant difference in survival rate (P < 0.01). Both ATA risk classification and TNM staging were significant predictors of disease-free survival. On bivariate analysis, ATA classification (hazards ratio, 2.1; 95% confidence interval, 1.64-2.67; P = 0.001) was better predictive of overall survival versus TNM classification (hazards ratio, 1.3; 95% confidence interval, 1.11-1.43; P = 0.063). The ATA risk stratification and continuous reassessment during the first 2 years predicts disease-free survival better than the TNM staging. Age older than 45 years, unresectable disease, and elevated postthyroidectomy thyroglobulin levels dictate a poorer prognosis.

PEMFC development at Asahi Glass Co., Ltd.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoshitake, M.; Yanagisawa, E.; Naganuma, T.

2000-07-01

Perfluorinated ion exchange membranes were studied and the membrane technology for PEMFC has been developed. Thermal stability, mechanical strength, water content, AC specific resistance and gas permeability were measured. The influence of membrane thickness on gas permeability and the influence of incorporation of cations on water content and AC specific resistance of Flemion{reg_sign} and Nafion{reg_sign}117 were estimated. Gas permeation rates of the membranes decreased in inverse proportion to the increase of the membrane thickness and gas permeability coefficients were nearly constant and independent of the thickness. Hydrogen permeation rates of Flemion S at 70 C were converted to 2.1 mA/cm{supmore » 2} as current density. Flemion R-electrode assembly showed to maintain stable performance for over 3,500 hr. Furthermore, it was found that usage of thinner membranes of one with higher ion-exchange capacity gave not only lower internal cell voltage but also higher IR-free cell voltage. PTFE-yarn embedded type membrane (Flemion Mc and Sc) and PTFE-fibril dispersed type (Flemion Rf2) was examined to afford improvement in mechanical strength at moist and high temperature atmosphere. Flemion Sc (80{micro}m) was examined to give high cell performance of 0.67V at 0.5A/cm2, 80 C, 1 ata. Flemion Mc-electrode assembly was examined to keep stable performance during the life test of over 1,500 hr.« less

A 2015 Survey of Clinical Practice Patterns in the Management of Thyroid Nodules.

PubMed

Burch, Henry B; Burman, Kenneth D; Cooper, David S; Hennessey, James V; Vietor, Nicole O

2016-07-01

The management of thyroid nodules has changed dramatically over the past two decades. In the interim, technological advances including high-resolution ultrasound and molecular testing of thyroid nodules have been introduced. We sought to document current practices in the management thyroid nodules and assess the extent to which technological advances have been incorporated into current practice. We further sought to compare current practice to recommendations made in a recently updated American Thyroid Association (ATA) clinical practice guideline (CPG) and examine differences in thyroid nodule management among international members of U.S.-based endocrine societies. Members of The Endocrine Society, ATA, and American Association of Clinical Endocrinologists were invited to participate in a Web-based survey dealing with testing, treatment preference, and modulating factors in patients with thyroid nodules. A total of 897 respondents participated in the survey, including 661 members of The Endocrine Society, 454 American Association of Clinical Endocrinologists members, and 365 ATA members. Thyroid fine-needle aspiration (FNA) in 2015 is generally performed by endocrinologists (56.6%) and radiologists (31.9%), most frequently using ultrasound guidance (83.3%). Respondents in general have a lower threshold for FNA of thyroid nodules than that recommended in the updated ATA CPG. Management depends on the FNA result, with follicular lesion of undetermined significance/atypia of undetermined significance resulting in molecular testing (38.8% of respondents), repeat FNA cytology (31.5%), or immediate referral for thyroid surgery (24.4%). Nodules showing follicular neoplasm by FNA are referred for thyroid surgery by 61.2% of respondents (46.6 % lobectomy, 14.6 % total thyroidectomy) or molecular testing (29.0 %). Nodules found suspicious but not conclusive for malignancy (Bethesda category V), are referred for thyroid surgery (86.0%) and rarely undergo molecular testing (9.5%). During pregnancy, only 47.6% of respondents would perform FNA in the absence of nodular growth, with most respondents deferring FNA until after pregnancy. Endocrinologists are 64.2% less likely to perform FNA in an octogenarian than a younger patient with a comparable thyroid nodule. Striking international differences were identified in the routine measurement of calcitonin and in the use of molecular testing of thyroid nodules. In summary, our survey of clinical endocrinologists on the management of thyroid nodules documents current practice patterns and demonstrates both concordance and focal discordance with recently updated CPGs. Both international differences and a change in practice patterns during the past two decades are demonstrated.

77 FR 41934 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-17

... Transport Association (ATA) of America Code 2800, Aircraft Fuel System. (e) Unsafe Condition This AD was... operational tests of the engine fuel suction feed of the fuel system, and other related testing if necessary... loss of boost pump pressure of the fuel feed system, followed by loss of fuel system suction feed...

Hyperbaric nitrogen prolongs breath-holding time in humans.

PubMed

Morooka, H; Wakasugi, Y; Shimamoto, H; Shibata, O; Sumikawa, K

2000-09-01

Either an increase in PaCO(2) or a decrease in PaO(2), can affect respiratory stimulation through respiratory centers, thus influencing breath-holding time (BHT). This study was designed to determine whether and how hyperbaric air could influence BHT in comparison with hyperbaric oxygen in humans. We studied 36 healthy volunteers in a multiplace hyperbaric chamber. BHT, pulse oximeter, and transcutaneous carbon dioxide tension were measured at 1 and 2.8 atmosphere absolute (ATA) in two groups. Group A (n = 20) breathed air. Group O (n = 16) breathed oxygen with a face mask (5 L/min). BHTs were 108 +/- 28 s at 1.0 ATA and 230 +/- 71 s at 2.8 ATA in Group A, and 137 +/- 48 s at 1.0 ATA and 180 +/- 52 s at 2.8 ATA in Group O. Transcutaneous carbon dioxide tension in Group A (59 +/- 2 mm Hg) was higher than that in Group O (54 +/- 2 mm Hg) at the end of maximal breath-holding at 2.8 ATA. The prolongation of BHT in hyperbaric air is significantly greater than that in hyperbaric oxygen. Breath-holding time is significantly prolonged in hyperbaric air than it is in hyperbaric oxygen. The mechanism involves the anesthetic effect of nitrogen suppressing the suffocating feeling during breath-holding.

Validation of American Thyroid Association Ultrasound Risk Assessment of Thyroid Nodules Selected for Ultrasound Fine-Needle Aspiration.

PubMed

Tang, Alice L; Falciglia, Mercedes; Yang, Huaitao; Mark, Jonathan R; Steward, David L

2017-08-01

The aim of this study was to validate the American Thyroid Association (ATA) sonographic risk assessment of thyroid nodules. The ATA sonographic risk assessment was prospectively applied to 206 thyroid nodules selected for ultrasound-guided fine-needle aspiration (US-FNA), and analyzed with The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), as well as surgical pathology for the subset undergoing surgical excision. The analysis included 206 thyroid nodules averaging 2.4 cm (range 1-7 cm; standard error of the mean 0.07). Using the ATA US pattern risk assessment, nodules were classified as high (4%), intermediate (31%), low (38%), and very low (26%) risk of malignancy. Nodule size was inversely correlated with sonographic risk assessment, as lower risk nodules were larger on average (p < 0.0001). Malignancy rates determined by cytology/surgical pathology were high 100%, intermediate 11%, low 8%, and very low 2%, which were closely aligned with ATA malignancy risk estimates (high 70-90%, intermediate 10-20%, low 5-10%, and very low 3%). ATA US pattern risk assessment also appropriately predicted the proportion of nodules classified as malignant or suspicious for malignancy through TBSRTC classification-high (77%), intermediate (6%), low (1%), and very low 0%-as well as benign TBSRTC classification-high (0%), intermediate (47%), low (61%), and very low (70%) (p < 0.0001). Malignancy rates of surgically excised, cytologically indeterminate nodules followed ATA sonographic risk stratification (high 100%, intermediate 21%, low 17%, and very low 12%; p = 0.003). This prospective study supports the new ATA sonographic pattern risk assessment for selection of thyroid nodules for US-FNA based upon TBSRTC and surgical pathology results. In the setting of indeterminate cytopathology, nodules categorized as atypia of undetermined significance/follicular lesion of undetermined significance with ATA high-risk sonographic patterns have a high likelihood of being malignant.

Human circulatory responses to prolonged hyperbaric hyperoxia in Predictive Studies V

NASA Technical Reports Server (NTRS)

Pisarello, J. B.; Clark, J. M.; Lambertsen, C. J.; Gelfand, R.

1987-01-01

Selected results of cardiocirculatory measurements in healthy volunteers who breathed 100 percent O2 continuously at 3.0 ATA for up to 3.5 hr, at 2.5 ATA for up to 6.0 hr, at 2.0 ATA for up to 11.9 hr, and at 1.5 ATA for up to 19.0 hr are reported. The results indicate that resting hemodynamic responses to prolonged hyperbaric oxygen breathing in man usually consist of small deviations from normal sea-level responses. Rapid onset of bradycardia occurred at all four oxygen pressures investigated. This effect was accompanied by a rate-dependent reduction in cardiac output and a degree of systematic vasoconstriction which were small in magnitude and appeared to be functionally unimportant.

Introducing English and German versions of the Adolescent Time Attitude Scale.

PubMed

Worrell, Frank C; Mello, Zena R; Buhl, Monika

2013-08-01

In this study, the authors report on the development of English and German versions of the Adolescent Time Attitude Scale (ATAS). The ATAS consists of six subscales assessing Past Positive, Past Negative, Present Positive, Present Negative, Future Positive, and Future Negative time attitudes. The authors describe the development of the scales and present data on the reliability and structural validity of ATAS scores in samples of American (N = 300) and German (N = 316) adolescents. Internal consistency estimates for scores on the English and German versions of the ATAS were in the .70 to .80 range. Confirmatory factor analyses indicated that a six-factor structure yielded the best fit for scores and that the scores were invariant across samples.

Using Genetic Buffering Relationships Identified in Fission Yeast To Elucidate the Molecular Pathology of Tuberous Sclerosis

DTIC Science & Technology

2016-07-01

5’-aat tat ttt ata tgg aat gag caa gta tgt ttt atc ata att gac cag ttc att tca agg acc ttc aaa aat ata cct acg aat tcg agc tcg ttt aaa c-3’), or...oTsc13 (5’-tta aga gtt cag att tgc ttt atg tgg tta ttc tgc tga agg tcc taa ttt att gac gtt gaa aaa taa agg cca cat agc gga tcc ccg ggt taa tta a-3...and oTsc14 (5’-ata aaa aaa att aat taa tga tgg caa ggc aca atc gta atc aat ctt tta att tag gac ttt tta tat gcc ctt atg gcg aat tcg agc tcg ttt aaa c

Concept Mapping in Science Class: A Case Study of Fifth Grade Students

ERIC Educational Resources Information Center

Asan, Askin

2007-01-01

The purpose of this research project was to determine the effects of incorporating concept mapping on the achievement of fifth grade students in science class. The study was conducted with twenty-three students at Ata Elementary School, Trabzon, Turkey. The students were tested with teacher-constructed pre- and post tests containing 20…

AtaT blocks translation initiation by N-acetylation of the initiator tRNAfMet.

PubMed

Jurėnas, Dukas; Chatterjee, Sneha; Konijnenberg, Albert; Sobott, Frank; Droogmans, Louis; Garcia-Pino, Abel; Van Melderen, Laurence

2017-06-01

Toxin-antitoxin (TA) loci are prevalent in bacterial genomes. They are suggested to play a central role in dormancy and persister states. Under normal growth conditions, TA toxins are neutralized by their cognate antitoxins, and under stress conditions, toxins are freed and inhibit essential cellular processes using a variety of mechanisms. Here we characterize ataR-ataT, a novel TA system, from enterohemorrhagic Escherichia coli. We show that the toxin AtaT is a GNAT family enzyme that transfers an acetyl group from acetyl coenzyme A to the amine group of the methionyl aminoacyl moiety of initiator tRNA. AtaT specifically modifies Met-tRNA fMet , but no other aminoacyl-tRNAs, including the elongator Met-tRNA Met . We demonstrate that once acetylated, AcMet-tRNA fMet fails to interact with initiation factor-2 (IF2), resulting in disruption of the translation initiation complex. This work reveals a new mechanism of translation inhibition and confirms Met-tRNA fMet as a prime target to efficiently block cell growth.

Qualitative and Semiquantitative Elastography for the Diagnosis of Intermediate Suspicious Thyroid Nodules Based on the 2015 American Thyroid Association Guidelines.

PubMed

Yang, Bo Ra; Kim, Eun-Kyung; Moon, Hee Jung; Yoon, Jung Hyun; Park, Vivian Y; Kwak, Jin Young

2018-04-01

To evaluate qualitative and semiquantitative elastography for the diagnosis of intermediate suspicious thyroid nodules based on the 2015 American Thyroid Association (ATA) guidelines. Through a retrospective search of our institutional database, 746 solid thyroid nodules found on grayscale ultrasonography, strain elastography, and ultrasound-guided fine-needle aspiration between June and November 2009 were collected. Among them, 80 nodules from 80 patients with an intermediate suspicion of malignancy based on the 2015 ATA guidelines that were 10 mm or larger were recruited as the final study nodules. Elastographic findings were categorized according to the criteria of Rago et al (J Clin Endocrinol Metab 2007; 92:2917-2922) and Asteria et al (Thyroid 2008; 18:523-531), and strain ratio values were calculated and recorded. The independent 2-sample t test and χ 2 test (or Fisher exact test) were used to evaluate differences in clinical parameters between benign and malignant thyroid nodules. All variables were compared by univariate and multivariate logistic regression analyses, and odds ratios with 95% confidence intervals were calculated. Of the 80 nodules, 6 (7.5%) were malignant, and 74 (92.5%) were benign. No significant differences were observed in age, sex, nodule size, elasticity score, and strain ratio between benign and malignant nodules. No variables significantly predicted thyroid malignancy on the univariate analysis. On the multivariate logistic regression analysis, there were no independent variables associated with thyroid malignancy, including the elasticity score and strain ratio (all P > .05). Elastographic analysis using the elasticity score and strain ratio has limited ability to characterize the benignity or malignancy of thyroid nodules with an intermediate suspicion of malignancy based on the 2015 ATA guidelines. © 2017 by the American Institute of Ultrasound in Medicine.

The ATA-67 Formula for Direct Operating Cost

NASA Technical Reports Server (NTRS)

Faulkner, H. B.

1972-01-01

The ATA formulas for direct operating cost were developed for the purpose of comparing different aircraft, existing or not, on the same route or the same aircraft on different routes. Such characteristics of the airline as crew pay, maintenance procedures, and depreciation schedules are kept constant. In air transportation systems analysis the 1967 ATA formula is usually used with appropriate exceptions or modifications, such as: different maintenance labor rate, total maintenance multiplied by a factor, maintenance burden deleted, different depreciation schedule, or different spares percentages.

Experimental determination with EPR-methods of dose loads on local population in inhabited localities adjacent to the tailing pond "Koshkar-ata" (Kazakhstan)

NASA Astrophysics Data System (ADS)

Kuterbekov, Kairat; Sadykov, Nurllah; Zhumadilov, Kassym; Nurgaliyeva, Rano; Kabyshev, Aset; Abseitov, Erbolat; Kurmanzhanov, Askar

2017-11-01

EPR study of TE from teeth donors in KOSHKAR-ATA region. During the first year we received22 tooth samples from local people in KOSHKAR-ATA region; the teeth were removed by dentists in accordance with their medical prescriptions. Obtained data showed that radiation signal in the analyzed samples corresponds to doses not exceeding 0.3 Gy; only one sample carriers the signal of (0.35±0.15)Gy.

Hydrostatic Extrusion of 60mm Mortar Tubes

DTIC Science & Technology

1974-10-01

Transverse "Tensile Test Specimen 16 9. Subsize Charpy and Tensile Test Specimens 17 10. Extruded 718 Alloy Tube Pressure-strain Pressure Test [)ata 18... subsize specimens. (d) Previous studies have shown that the standard size Charpy values are 4.5 times the subsize values. 22 -. •. ., *. ...20 II. Tensile Properties of Extruded and Aged Tube (a) 21 III. Extruded 718 Alloy Pressure Test Data 21 IV. V-Notch Charpy Impact Properties(c) of

Design, development and evaluation of driver wellness programs. Technical memorandum 3 : pilot test results and marketing plan

DOT National Transportation Integrated Search

1999-10-31

In May, 1997, the National Private Truck Councils (NPTC) Private Fleet Management Institute (PFMI) began a research program in cooperation with Sue Roberts Health Concepts, Inc., ATA Foundation, Inc., and the Federal Motor Carrier Safety Administr...

Carboxyhemoglobin half-life during hyperbaric oxygen in a patient with lung dysfunction: a case report.

PubMed

Weaver, Lindell K; Deru, Kayla

2017-01-01

The carboxyhemoglobin half-life (COHb t1/2) during hyperbaric oxygen (HBO₂) is often quoted as 23 minutes, derived from the average of two adult male volunteers breathing HBO₂ at 3 atmospheres absolute (ATA). However, the mean COHb t1/2 of 12 male volunteer smokers was 26.3 minutes at 1.58 ATA and in 12 non-intubated carbon monoxide (CO) poisoned patients treated at 3 ATA, was 43 minutes. An 81-year old male, poisoned by an improperly ventilated natural gas heater, was intubated for coma, then treated with HBO₂. His PaO₂/FiO₂ = 283 from aspiration. His initial COHb was 34.4%, and 18 minutes before HBO₂, 5.9%. After a compression interval of 17 minutes, the COHb measured after 22 minutes at 3 ATA was 3.3%. By exponential decay, his COHb t1/2 before HBO₂ was 95 minutes. We estimate the range for COHb t1/2 during compression as 62-81 minutes and for the 3-ATA interval, 58 to 49 minutes, respectively. The mid-point estimate of COHb t1/2 at 3 ATA was 53 minutes. The COHb t1/2 we calculated is greater than previously reported, but longer in our patient possibly because of concomitant respiratory failure, lung dysfunction, and mechanical ventilation. The often-cited COHb t1/2 of 23 minutes, likely underestimates the actual COHb t1/2 in CO-poisoned patients, especially those with cardiopulmonary dysfunction.

Photoalignment of a Bisazodioxodibenzothiophene in a Polyvinylpyrrolidone Matrix

NASA Astrophysics Data System (ADS)

Chaplanova, J. D.; Larykava, S. N.; Agabekov, V. E.; Mikulich, V. S.; Gracheva, E. A.

2016-09-01

Photoalignment of thin films of dipotassium 3,7-bis[1-(4-hydroxy-3-carboxylate)phenylazo]-5,5'-dioxodibenzothiophene (AtA-2) that were prepared by spin-coating of dye solutions in H2O and DMF and aqueous solutions of polyvinylpyrrolidone (PVP) was studied. The UV absorption band of the dye cis-isomer, the position and intensity of which depended on the PVP concentration in the stock solutions, was recorded upon irradiation of films of AtA-2 in a PVP matrix [AtA-2(PVP)] with unfi ltered light from a DRT-1000 lamp in a vacuum or an Ar atmosphere. PVP facilitated trans-cis isomerization of AtA-2 and increased the stability of the cis-isomer with respect to thermal relaxation into the initial trans-isomer. The dichroic ratio (DR) of AtA-2(PVP) films irradiated with linearly polarized light (blue LED with λ = 450 nm, I = 15 mW/cm2) increased by 1.5 times as the PVP concentration in the stock solutions increased from 1.0 to 10.0 mass%. The morphology and roughness of the films depended on the nature of the solvents used to prepare them.

Delayed risk stratification, to include the response to initial treatment (surgery and radioiodine ablation), has better outcome predictivity in differentiated thyroid cancer patients.

PubMed

Castagna, Maria Grazia; Maino, Fabio; Cipri, Claudia; Belardini, Valentina; Theodoropoulou, Alexandra; Cevenini, Gabriele; Pacini, Furio

2011-09-01

After initial treatment, differentiated thyroid cancer (DTC) patients are stratified as low and high risk based on clinical/pathological features. Recently, a risk stratification based on additional clinical data accumulated during follow-up has been proposed. To evaluate the predictive value of delayed risk stratification (DRS) obtained at the time of the first diagnostic control (8-12 months after initial treatment). We reviewed 512 patients with DTC whose risk assessment was initially defined according to the American (ATA) and European Thyroid Association (ETA) guidelines. At the time of the first control, 8-12 months after initial treatment, patients were re-stratified according to their clinical status: DRS. Using DRS, about 50% of ATA/ETA intermediate/high-risk patients moved to DRS low-risk category, while about 10% of ATA/ETA low-risk patients moved to DRS high-risk category. The ability of the DRS to predict the final outcome was superior to that of ATA and ETA. Positive and negative predictive values for both ATA (39.2 and 90.6% respectively) and ETA (38.4 and 91.3% respectively) were significantly lower than that observed with the DRS (72.8 and 96.3% respectively, P<0.05). The observed variance in predicting final outcome was 25.4% for ATA, 19.1% for ETA, and 62.1% for DRS. Delaying the risk stratification of DTC patients at a time when the response to surgery and radioiodine ablation is evident allows to better define individual risk and to better modulate the subsequent follow-up.

Epitope characterization of pre-existing and developing antibodies to an aglycosylated monoclonal antibody therapeutic of G1m17,1 allotype.

PubMed

Tatarewicz, Suzanna M; Juan, Gloria; Swanson, Steven J; Moxness, Michael S

2012-08-31

Allotypes of IgG1 molecules can influence the immunogenicity of therapeutic monoclonal antibodies and may account for the presence of some pre-existing antibodies. An electrochemiluminescent (ECL) bridging immunoassay was used to characterize the binding epitopes of anti-therapeutic antibodies (ATAs) in a Phase 1 single ascending dose clinical trial of a therapeutic aglycosylated IgG1monoclonal antibody (mAb). There was no evidence for ATAs specific for a possible neo-epitope created due to the lack of glycosylation. ATAs that developed post-treatment were specific for the F(ab')2, whereas, pre-existing ATAs were specific to the Fc region. Further characterization of the pre-existing ATAs identified the specific epitope to be the G1m1 allotype determinant in the Fc of the therapeutic. A novel competitive bridging assay was developed to verify that serum IgG1 from subjects with pre-existing anti-G1m1 antibodies was homozygous for the antithetical allotype (G1m3). The endogenous G1m allotype of all subjects was assessed and correlation to ATA incidence and adverse events was evaluated. Interestingly, the pre-existing anti-allotype antibody in subjects persisted but was not augmented after dosing, indicating the lack of a secondary immune response to this epitope. These studies indicate the relationship of the therapeutic allotype and the corresponding allotype of subjects is an important component to further understand the impact of immunogenicity on the safety and efficacy of therapeutic antibodies. Copyright © 2012 Elsevier B.V. All rights reserved.

Evaluation of the Carefusion Alaris PC infusion pump for hyperbaric oxygen therapy conditions: Technical report.

PubMed

Smale, Andrew; Tsouras, Theo

2017-01-01

We present a standardized test methodology and results for our evaluation of the Carefusion Alaris PC infusion pump, comprising the model 8015 PC Unit and the model 8100 Large Volume Pump (LVP) module. The evaluation consisted of basic suitability testing, internal component inspection, surface temperature measurement of selected internal components, and critical performance testing (infusion rate accuracy and occlusion alarm pressure) during conditions of typical hyperbaric oxygen (HBO₂) treatment in our facility's class A multiplace chamber. We have found that the pumps pose no enhanced risk as an ignition source, and that the pumps operate within manufacturer's specifications for flow rate and occlusion alarms at all stages of HBO₂ treatments, up to 4.0 ATA and pressurization and depressurization rates up to 180 kPa/minute. The pumps do not require purging with air or nitrogen and can be used unmodified, subject to the following conditions: pumps are undamaged, clean, fully charged, and absent from alcohol cleaning residue; pumps are powered from the internal NiMH battery only; maximum pressure exposure 4.0 ATA; maximum pressurization and depressurization rate of 180 kPa/minute; LVP modules locked in place with retaining screws. Copyright© Undersea and Hyperbaric Medical Society.

The Improved Three Axis Test Table (ITATT): Program Status and Recommendation for Completion

DTIC Science & Technology

1990-08-01

8ihMs Group qo O4e3/ 023 1 WfltlhfJ____________. Contraves USA U’NTERIM REPORT ON THIE IMPROVED) THREE AXIS TEST TABLE (ITATh): PROGRAM STATUS AND...Bhirle Group £OIn VHI TR-27824 Page i. Contraves USA TABLE OF CONTENTS Page I INTRODUCTION - EXECUTIVE SUMMARY ........................ 1 2 PURPOSE...D ata . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 4.1.3 What Has Contraves Learned? .......................... 8

Modelling of atorvastatin pharmacokinetics and the identification of the effect of a BCRP polymorphism in the Japanese population.

PubMed

Tsamandouras, Nikolaos; Guo, Yingying; Wendling, Thierry; Hall, Stephen; Galetin, Aleksandra; Aarons, Leon

2017-01-01

Ethnicity plays a modulating role in atorvastatin pharmacokinetics (PK), with Asian patients reported to have higher exposure compared with Caucasians. Therefore, it is difficult to safely extrapolate atorvastatin PK data and models across ethnic groups. This work aims to develop a population PK model for atorvastatin and its pharmacologically active metabolites specifically for the Japanese population. Subsequently, it aimed to identify genetic polymorphisms affecting atorvastatin PK in this population. Atorvastatin acid (ATA) and ortho-hydroxy-atorvastatin acid (o-OH-ATA) plasma concentrations, clinical/demographic characteristics and genotypes for 18 (3, 3, 1, 1, 7, 2 and 1 in the ABCB1, ABCG2, CYP3A4, CYP3A5, SLCO1B1, SLCO2B1 and PPARA genes, respectively) genetic polymorphisms were collected from 27 Japanese individuals (taking 10 mg atorvastatin once daily) and analysed using a population PK modelling approach. The population PK model developed (one-compartment for ATA linked through metabolite formation to an additional compartment describing the disposition of o-OH-ATA) accurately described the observed data and the associated population variability. Our analysis suggested that patients carrying one variant allele for the rs2622604 polymorphism (ABCG2) show a 55% (95% confidence interval: 16-131%) increase in atorvastatin oral bioavailability relative to the value in individuals without the variant allele. The current work reports the identification in the Japanese population of a BCRP polymorphism, not previously associated with the PK of any statin, that markedly increases ATA and o-OH-ATA exposure. The model developed may be of clinical importance to guide dosing recommendations tailored specifically for the Japanese.

DNA binding, anti-inflammatory and analgesic evaluation of metal complexes of N/S/O donor ligands; Synthesis, spectral characterization

NASA Astrophysics Data System (ADS)

Kumar Naik, K. H.; Ashok, B.; Naik, Nagaraja; Mulla, Jameel Ahmed S.; Prakasha, Avinash

2015-04-01

Transition metal complexes containing tri-dentate NSN donor ligands i.e., 5-((1(aminomethyl)cyclohexyl)methyl)-1,3,4-thiadiazol-2-amine (AMTA) (2) and 5-(2-aminophenyl)-1,3,4-thiadiazol-2-amine (ATA) (4i-ii) have been synthesized. The newly synthesized ligands and their respective complexes were characterized by elemental analysis, molar conductance measurement and various spectral studies [infrared (IR), electronic, and NMR (for ligands only)]. Metal complexes are like [M(AMTA)2], [M(ATA)2] type, where M = Mn(II), Co(II) and Cu(II). The proposed geometries of the complexes are octahedral in nature. The synthesized ligands and their complexes were exhibits effective anti-inflammatory, analgesic and DNA binding activities. All the tested compounds exhibited significant analgesic activity, whereas the compound 4i, 4(ia) and 4(iib) is equipotent with Diclofenac sodium.

Patient-centered technological assessment and monitoring of depression for low-income patients.

PubMed

Wu, Shinyi; Vidyanti, Irene; Liu, Pai; Hawkins, Caitlin; Ramirez, Magaly; Guterman, Jeffrey; Gross-Schulman, Sandra; Sklaroff, Laura Myerchin; Ell, Kathleen

2014-01-01

Depression is a significant challenge for ambulatory care because it worsens health status and outcomes, increases health care utilizations and costs, and elevates suicide risk. An automatic telephonic assessment (ATA) system that links with tasks and alerts to providers may improve quality of depression care and increase provider productivity. We used ATA system in a trial to assess and monitor depressive symptoms of 444 safety-net primary care patients with diabetes. We assessed system properties, evaluated preliminary clinical outcomes, and estimated cost savings. The ATA system is feasible, reliable, valid, safe, and likely cost-effective for depression screening and monitoring for low-income primary care population.

Toxicity of nonylphenol diethoxylate in lab-scale anaerobic digesters.

PubMed

Bozkurt, Hande; Sanin, F Dilek

2014-06-01

Nonylphenol compounds have high commercial, industrial and domestic uses owing to their surface active properties. In addition to their toxic, carcinogenic and persistent characteristics; they have drawn the attention of scientists lately due to their endocrine disrupting properties. Their widespread use and disposal cause them to enter wastewater treatment systems at high concentrations. Since they are highly persistent and hydrophobic, they accumulate mostly on sludge. In this study using Anaerobic Toxicity Assay (ATA) tests, the toxicity of a model nonylphenol compound, nonylphenol diethoxylate (NP2EO), for anaerobic digestion of sludge was determined. The test bottles were dosed with NP2EO in acetone, with concentrations ranging from 1 mg L(-1) to 30 mg L(-1). During the tests, gas productions and compositions in terms of methane and carbon dioxide were monitored. To be able to judge about the fate, the target compounds were extracted from water and sludge and analyzed using GC/MS. The sludge samples used for assembling the reactors were found to contain NP and NP1EO but no NP2EO. After the assay was completed, all the NP2EO spiked into the live reactors was found to disappear. The increase seen in NP1EO and NP and further accumulation of NP in the system, indicated the conversion of NP2EO to these metabolites. On the other hand, no conversion was observed in abiotic reactors. Inhibition of NP2EO for anaerobic microorganisms was not observed throughout the tests considering the biogas production of the test reactors in comparison to the control reactors. Copyright © 2013 Elsevier Ltd. All rights reserved.

Hyperbaric pressure effects measured by growth of a transplantable tumor in the C3H/HeN mouse.

PubMed

Herndon, B L; Lally, J J

1984-09-01

Both hypobaric exposure at 0.5 atmospheres absolute (ATA) and hyperbaric pressure exposure at 3.5-8 ATA slowed transplantable tumor growth. These experiments detailed the hyperbaric pressure exposure. C3H/HeN-MTV+ mice, bearing the 16/C transplantable murine mammary adenocarcinoma and exposed to 18 days' treatment by a hyperbaric chamber at 3.5-8 ATA, had tumor weights that averaged 50-75% less than the tumor weights in mice caged at ambient ("sea level") pressure. A series of experiments was run to investigate this response to hyperbaric pressure exposure. After mice underwent continuous exposure to 3.5-8 ATA normoxic (normal oxygen) hyperbaric pressure with use of either argon or nitrogen inert gas, which began 3 days after tumor inoculation, tumors were removed at about 3 weeks' growth from these pressure-exposed mice and measured for growth by weighing. Final tumor weight in pressure-exposed experimental mice was significantly less than tumor weight in paired groups of tumor-bearing controls that received no hyperbaric pressure. Tumor weight was inversely related to pressure "dose," although the small pressure range produced an effect at all pressures used. The number of compression-decompression cycles to which the animals were subjected, however, was related positively to tumor weight at necropsy. Continued tumor growth in mice subjected to frequent pressure change (in conjunction with pressure exposure that otherwise limited tumor size) was unexplained by these experiments. The greatest difference between tumor weights in controls and pressure-exposed animals was seen with 2 weeks' continuous pressure exposure. A limited profile of blood tests was performed, and these reflected only minor, expected change in the pressure-exposed experimental animals. The data at hand did not suggest a mechanism by which chronic normoxic hyperbaric pressure limited tumor size.

A 2011 survey of clinical practice patterns in the management of Graves' disease.

PubMed

Burch, Henry B; Burman, Kenneth D; Cooper, David S

2012-12-01

More than two decades have passed since members from the American Thyroid Association (ATA), European Thyroid Association, and Japan Thyroid Association were surveyed on management practices for patients with hyperthyroidism due to Graves' disease (GD). We sought to document current practices in the management of GD and compare these results both to those documented in earlier surveys and to practice recommendations made in the 2011 ATA/American Association of Clinical Endocrinologists (AACE) hyperthyroidism practice guidelines. Lastly, we sought to examine differences in GD management among international members of U.S.-based endocrine societies. Members of The Endocrine Society (TES), ATA, and AACE were invited to participate in a web-based survey dealing with testing, treatment preference, and modulating factors in patients with GD. A total of 730 respondents participated in the survey, 696 of whom completed all sections. Respondents included 641 TES members, 330 AACE members, and 157 ATA members. The preferred mode of therapy in uncomplicated GD was antithyroid drugs (ATDs) by 53.9% of respondents, radioactive iodine (RAI) therapy by 45.0%, and thyroid surgery in 0.7%. Compared with 1991, fewer U.S. (59.7 vs. 69%) and European (13.3% vs. 25%) respondents would use RAI therapy. Methimazole and carbimazole were the preferred ATDs, with only 2.7% of respondents selecting propylthiouracil. Patients with Graves' ophthalmopathy were treated with ATDs (62.9%) or surgery (18.5%) and less frequently with RAI plus corticosteroids (16.9%) or RAI alone (1.9%). Striking changes have occurred in the management of GD over the past two decades, with a shift away from RAI and toward ATDs in patients with uncomplicated GD. Apparent international differences persist but should be interpreted with caution. Current practices diverge in some areas from recently published guidelines; these differences should be assessed serially to determine the impact of the guidelines on future clinical practice.

Patient-Centered Technological Assessment and Monitoring of Depression for Low-Income Patients

PubMed Central

Wu, Shinyi; Vidyanti, Irene; Liu, Pai; Hawkins, Caitlin; Ramirez, Magaly; Guterman, Jeffrey; Gross-Schulman, Sandra; Sklaroff, Laura Myerchin; Ell, Kathleen

2014-01-01

Depression is a significant challenge for ambulatory care because it worsens health status and outcomes, increases health care utilizations and costs, and elevates suicide risk. An automatic telephonic assessment (ATA) system that links with tasks and alerts to providers may improve quality of depression care and increase provider productivity. We used ATA system in a trial to assess and monitor depressive symptoms of 444 safety-net primary care patients with diabetes. We assessed system properties, evaluated preliminary clinical outcomes, and estimated cost savings. The ATA system is feasible, reliable, valid, safe, and likely cost-effective for depression screening and monitoring for low-income primary care population. PMID:24525531

Electron momentum densities in disordered muffin-tin alloys

NASA Astrophysics Data System (ADS)

Bansil, A.; Rao, R. S.; Mijnarends, P. E.; Schwartz, L.

1981-04-01

The application of average t-matrix (ATA) and coherent potential (CPA) approximations to the calculation of average electron momentum density ρ(p-->) in random muffin-tin alloys AxB1-x is considered. The necessary equations for the general matrix elements of the operators describing scattering by the CPA atom and also by an A or B atom embedded in the effective medium are derived. Various versions of the ATA for ρ(p-->) are discussed. Several ρ(p-->) curves calculated on the basis of the CPA and ATA in CuxNi1-x are presented. These results are used to delineate the effects on ρ(p-->) of self-consistency in the treatment of disorder.

Ashford Teaching Alliance Research Champion: Evaluation Report and Executive Summary

ERIC Educational Resources Information Center

Griggs, Julia; Speight, Svetlana; Farias, Javiera Cartagena

2016-01-01

The Ashford Teaching Alliance (ATA) Research Champion project ("the programme") was a pilot intervention aimed at developing teaching expertise and practice by promoting the use of educational research in decision-making and teacher practice. The programme ran for one academic year (2014/2015) in five schools within the ATA. Delivery was…

19 CFR 114.23 - Maximum period.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 19 Customs Duties 1 2010-04-01 2010-04-01 false Maximum period. 114.23 Section 114.23 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CARNETS Processing of Carnets § 114.23 Maximum period. (a) A.T.A. carnet. No A.T.A. carnet with a period...

Ata: An Indigenous Knowledge Based Pedagogical Approach to Teaching

ERIC Educational Resources Information Center

Forsyth, Huhana

2017-01-01

Western education theory and philosophy as the domain of the dominant pedagogy forms the basis of the New Zealand education system. Although the current form of education is reflective of the dominant cultures ideologies and philosophies it does not always serve the interests of all students. The philosophy of Ata offers an indigenous knowledge…

The Petunia GRAS Transcription Factor ATA/RAM1 Regulates Symbiotic Gene Expression and Fungal Morphogenesis in Arbuscular Mycorrhiza1

PubMed Central

Rich, Mélanie K.

2015-01-01

Arbuscular mycorrhiza (AM) is a mutual symbiosis that involves a complex symbiotic interface over which nutrients are exchanged between the plant host and the AM fungus. Dozens of genes in the host are required for the establishment and functioning of the interaction, among them nutrient transporters that mediate the uptake of mineral nutrients delivered by the fungal arbuscules. We have isolated in a genetic mutant screen a petunia (Petunia hybrida) GIBBERELLIC ACID INSENSITIVE, REPRESSOR of GIBBERELLIC ACID INSENSITIVE, and SCARECROW (GRAS)-type transcription factor, ATYPICAL ARBUSCULE (ATA), that acts as the central regulator of AM-related genes and is required for the morphogenesis of arbuscules. Forced mycorrhizal inoculations from neighboring wild-type plants revealed an additional role of ATA in restricting mycorrhizal colonization of the root meristem. The lack of ATA, which represents the ortholog of REQUIRED FOR ARBUSCULAR MYCORRHIZA1 in Medicago truncatula, renders the interaction completely ineffective, hence demonstrating the central role of AM-related genes for arbuscule development and function. PMID:25971550

The Petunia GRAS Transcription Factor ATA/RAM1 Regulates Symbiotic Gene Expression and Fungal Morphogenesis in Arbuscular Mycorrhiza.

PubMed

Rich, Mélanie K; Schorderet, Martine; Bapaume, Laure; Falquet, Laurent; Morel, Patrice; Vandenbussche, Michiel; Reinhardt, Didier

2015-07-01

Arbuscular mycorrhiza (AM) is a mutual symbiosis that involves a complex symbiotic interface over which nutrients are exchanged between the plant host and the AM fungus. Dozens of genes in the host are required for the establishment and functioning of the interaction, among them nutrient transporters that mediate the uptake of mineral nutrients delivered by the fungal arbuscules. We have isolated in a genetic mutant screen a petunia (Petunia hybrida) Gibberellic Acid Insensitive, Repressor of Gibberellic Acid Insensitive, and Scarecrow (GRAS)-type transcription factor, Atypical Arbuscule (ATA), that acts as the central regulator of AM-related genes and is required for the morphogenesis of arbuscules. Forced mycorrhizal inoculations from neighboring wild-type plants revealed an additional role of ATA in restricting mycorrhizal colonization of the root meristem. The lack of ATA, which represents the ortholog of Required For Arbuscular Mycorrhiza1 in Medicago truncatula, renders the interaction completely ineffective, hence demonstrating the central role of AM-related genes for arbuscule development and function. © 2015 American Society of Plant Biologists. All Rights Reserved.

The effects of pressure on arthritic knees in a rat model of CFA-induced arthritis.

PubMed

Koo, Sung Tae; Lee, Chang-Hyung; Choi, Hyeunseok; Shin, Yong Il; Ha, Ki Tae; Ye, Hanna; Shim, Hyun Bo

2013-01-01

Pain is influenced by weather changes under certain circumstances, and inflammatory pain in animal models is ameliorated by pressure, but the underlying mechanism of atmospheric pressure has not been clearly elucidated. To examine the effect of pressure on pain in an arthritic animal model. Controlled animal study. Laboratory animal study. Following an injection of complete Freund's adjuvant (CFA) into one side of a knee joint, 32 rats were assigned randomly to 2 groups and either placed under 1 or 2.5 atmospheres absolute (ATA) in a hyperbaric chamber for 5 hours. The pain levels were assessed daily for up to 2 weeks post-injection to determine the changes in weight bearing (WB) of the affected limbs. In addition, the levels of gelatinase, MMP-2, and MMP-9 expression in the synovial fluids of the knees were analyzed. After arthritis induction, the rats in the 1 ATA group showed reduced WB of the affected limbs (< 10% of normal limbs). This reduction in WB peaked at 2 days after the injection and then decreased spontaneously. Nevertheless, the pain behavior lasted for more than 2 weeks. In the 2.5 ATA group, the WB was significantly better during the experiment.  The MMP-9/MMP-2 ratio increased at 7 and 14 days after the CFA injection in the 1 ATA group. However, repetitive exposure to 2.5 ATA significantly reduced this ratio in the 2.5 ATA group. Although a sufficient number of samples were used to support the hypothesis that high atmospheric pressure improves a painful condition in this study, an additional larger-scale study will be needed to confirm these findings. Exposure to elevated pressures appears to relieve arthritic pain for extended periods by reducing the inflammatory process and should be considered as a possible alternative pain-reducing therapy.

Traumatic Brain Injury and Hyperbaric Oxygen Therapy Dawn of a New Day

DTIC Science & Technology

2017-09-07

Both used to test for differences between groups • No significant statistical difference between groups, but both groups improved • Relative...George Wolf, Laura M . Baugh, Christine M. Schubert Kabban, Michael F. Richards, Jennifer Prye • Individual test scores • ImPACT: • visual memory and...Stem cells collected prior to series, after 15 exposures. after 30 exposure series, and 6 weel< post series. • 13 subjects from 1.3 ATA air and 15

Supporting Democratic Discourses of Teacher Professionalism: The Case of the Alberta Teachers' Association

ERIC Educational Resources Information Center

Osmond-Johnson, Pamela

2015-01-01

This paper explores understandings related to teacher professionalism amongst a sample of highly engaged members of the Alberta Teacher's Association (ATA). Highlighting the many ways in which the Association supported members in their bid to embody roles as leaders, learners, advocates, and policy actors, I argue that the ATA serves as a platform…

The Development of a Portable Hard Disk Encryption/Decryption System with a MEMS Coded Lock.

PubMed

Zhang, Weiping; Chen, Wenyuan; Tang, Jian; Xu, Peng; Li, Yibin; Li, Shengyong

2009-01-01

In this paper, a novel portable hard-disk encryption/decryption system with a MEMS coded lock is presented, which can authenticate the user and provide the key for the AES encryption/decryption module. The portable hard-disk encryption/decryption system is composed of the authentication module, the USB portable hard-disk interface card, the ATA protocol command decoder module, the data encryption/decryption module, the cipher key management module, the MEMS coded lock controlling circuit module, the MEMS coded lock and the hard disk. The ATA protocol circuit, the MEMS control circuit and AES encryption/decryption circuit are designed and realized by FPGA(Field Programmable Gate Array). The MEMS coded lock with two couplers and two groups of counter-meshing-gears (CMGs) are fabricated by a LIGA-like process and precision engineering method. The whole prototype was fabricated and tested. The test results show that the user's password could be correctly discriminated by the MEMS coded lock, and the AES encryption module could get the key from the MEMS coded lock. Moreover, the data in the hard-disk could be encrypted or decrypted, and the read-write speed of the dataflow could reach 17 MB/s in Ultra DMA mode.

Hereditary medullary thyroid carcinoma: the management dilemma.

PubMed

Zhou, Ping; Liu, Jian; Cheng, Shao-Wen; Wang, Bing; Yang, Rong; Peng, Ling

2012-06-01

Hereditary medullary thyroid carcinoma (hereditary MTC) is a rare malignancy, accounting for 25-30% of all MTC. It occurs as part of multiple endocrine neoplasia type 2 (MEN 2). Autosomal dominant gain-of-function mutations in the RET proto-oncogene is the cause of the disease, in which the common mutations are codons 609, 611, 618, 620, 630, 634 and 918. In recent years, the spectrum of RET gene mutations has changed. The classical mutations reduced, whereas the less aggressive mutations increased. Hereditary MTC is a time-dependent disease. Stages of the disorder at diagnosis can significantly influence survival rates. Based on the genotype-phenotype, RET mutations have been classified into four risk levels by American Thyroid Association (ATA) at 2009. The classification system guides the hereditary MTC management, including risk assessment, biochemical screenings and surgical intervention. Though the application of genetic testing and codon-specific phenotypes in hereditary MTC diagnosis is effective with high accuracy, there are some difficulties in implementing RET gene testing as a routine for MTC diagnosis. And most of carriers with RET mutations did not undergo thyroidectomy at the age recommended by the ATA guidelines. The aim of the study is to review the hereditary MTC and discuss the management dilemma.

Analytical model for atomic resonant attosecond transient absorption

NASA Astrophysics Data System (ADS)

Cariker, C.; Kjellson, T.; Lindroth, E.; Argenti, L.

2017-04-01

Recent advancements in ultrafast laser technology have made it possible to probe electron dynamics in highly excited atomic states that autoionize on a femtosecond timescale, thus giving insight into the dynamics of Auger decay and its interference with the continuum. These experiments provide a stringent test for time-resolved analytical models of autoionization. Here we present a finite-pulse, multi-photon perturbative model which is used in conjunction with ab-initio structure calculations to predict the attosecond transient absorption spectrum (ATAS) of an atom above the ionization threshold. We apply this model to compute the ATAS of argon in the vicinity of the 3s-1 4 p resonance as a function of the time delay between an extreme ultraviolet (XUV) and an infrared (IR) pulse, as well as of the angle between their polarization. We show that by modulating the parameters of the IR pulse it is possible to control the dipolar coupling between neighboring states and hence the lineshape of the 3s-1 4 p resonance. NSF Grant No. 1607588.

Primary health care approach. Its relevance to oral health in Nigeria.

PubMed

Ndiokwelu, E

2002-09-01

This article discusses the concept of Primary Health Care--an idea which started with the World Health Assembly agreement in 1977 to work resolutely towards the goal of Health for All. This decision was followed by the historic international conference on Primary Health Care at Alma Ata in 1978. Many countries including Nigeria, adopted the primary health care strategy to achieve health for all by the year 2000 (now 2000 and beyond). Since health needs to be seen and dealt with in a holistic manner, oral health is an integral part of health. Strategies for achieving health for all implicitly and must of necessity involve oral health. This article has tried to show the relevance of the strategy of primary health care to oral health. It concludes that primary health care approach is very relevant to oral health in Nigeria.

19 CFR 114.34 - Cancellation of erroneous charges.

Code of Federal Regulations, 2011 CFR

2011-04-01

... in force a ruling by the Commissioner of Customs decisive of the issue. [T.D. 74-227, 39 FR 32023... cancelled by the port director and, if paid, refunded, as provided by § 18.8 of this chapter. (b) A.T.A. or... reexport or destroy merchandise temporarily imported under cover of an A.T.A. or TECRO/AIT carnet did not...

19 CFR 114.34 - Cancellation of erroneous charges.

Code of Federal Regulations, 2010 CFR

2010-04-01

... in force a ruling by the Commissioner of Customs decisive of the issue. [T.D. 74-227, 39 FR 32023... cancelled by the port director and, if paid, refunded, as provided by § 18.8 of this chapter. (b) A.T.A. or... reexport or destroy merchandise temporarily imported under cover of an A.T.A. or TECRO/AIT carnet did not...

Advanced drug delivery systems for antithrombotic agents

PubMed Central

Greineder, Colin F.; Howard, Melissa D.; Carnemolla, Ronald; Cines, Douglas B.

2013-01-01

Despite continued achievements in antithrombotic pharmacotherapy, difficulties remain in managing patients at high risk for both thrombosis and hemorrhage. Utility of antithrombotic agents (ATAs) in these settings is restricted by inadequate pharmacokinetics and narrow therapeutic indices. Use of advanced drug delivery systems (ADDSs) may help to circumvent these problems. Various nanocarriers, affinity ligands, and polymer coatings provide ADDSs that have the potential to help optimize ATA pharmacokinetics, target drug delivery to sites of thrombosis, and sense pathologic changes in the vascular microenvironment, such as altered hemodynamic forces, expression of inflammatory markers, and structural differences between mature hemostatic and growing pathological clots. Delivery of ATAs using biomimetic synthetic carriers, host blood cells, and recombinant fusion proteins that are activated preferentially at sites of thrombus development has shown promising outcomes in preclinical models. Further development and translation of ADDSs that spare hemostatic fibrin clots hold promise for extending the utility of ATAs in the management of acute thrombotic disorders through rapid, transient, and targeted thromboprophylaxis. If the potential benefit of this technology is to be realized, a systematic and concerted effort is required to develop clinical trials and translate the use of ADDSs to the clinical arena. PMID:23798715

Aurintricarboxylic acid is a potent inhibitor of phosphofructokinase.

PubMed Central

McCune, S A; Foe, L G; Kemp, R G; Jurin, R R

1989-01-01

Aurintricarboxylic acid (ATA) was found to be a very potent inhibitor of purified rabbit liver phosphofructokinase (PFK), giving 50% inhibition at 0.2 microM. The inhibition was in a manner consistent with interaction at the citrate-inhibitory site of the enzyme. The data suggest that inhibition of PFK by ATA was not due to denaturation of the enzyme or the irreversible binding of inhibitor, since the inhibition could be reversed by addition of allosteric activators of PFK, i.e. fructose 2,6-bisphosphate or AMP. Two other tricarboxylic acids, agaric acid and (-)-hydroxycitrate, were found to inhibit PFK. ATA at much higher concentrations (500 microM) was shown to inhibit fatty acid synthesis from endogenous glycogen in rat hepatocytes; however, protein synthesis was not altered. PMID:2525029

Hyperbaric pressure does not affect the analgesia produced by nitrous oxide in the mouse.

PubMed

Cohen, P J

1989-01-01

Hydrostatic pressure antagonizes some, but not all, of the phenomena associated with general anaesthesia. For example, while unconsciousness produced by general anaesthesia in a wide variety of species is reversed by compression, anaesthetic-induced inhibition of synaptic transmission is potentiated by application of pressure. To date, the effect of pressure on analgesia has not been evaluated. In this study, hyperbaric pressure of 75 ata did not antagonize analgesia which had been produced by exposure of mice to 1.2 ata of nitrous oxide. However, the same hyperbaric pressure restored righting in animals which had been anesthetized with 1.5 ata of nitrous oxide. These data add to the suggestion that the multiple effects of general anaesthetics may be mediated at different loci.

Advancing Aeronautics: A Decision Framework for Selecting Research Agendas

DTIC Science & Technology

2011-01-01

Engineering Board ASME American Society of Mechanical Engineers ATA Air Transport Association ATM air traffic management ATP Aeronautics Test Program...not provide a competitive advantage for a sufficient period to justify the R&D outlay. Such projects can include technolo- gies that address...fuel efficiency improvements multiplied by the cost of fuel would provide an estimate of their value to society. Likewise, technolo- gies for

Employer Partnership Program Analysis of Alternatives

DTIC Science & Technology

2012-01-01

downloaded many more job listings. These results suggest that there is room for improvement in outreach to RC service members and attracting return visits to...Area of Concentration ARNG Army National Guard ATA American Trucking Association CBRN Chemical, Biological, Radiological, and Nuclear CMF Career...Association ( ATA ) and Inova Health Systems, a nonprofit health care provider in Northern Virginia. In July 2008, the program signed its first agreement

DOE Office of Scientific and Technical Information (OSTI.GOV)

Friedman, A.; Barnard, J.J.; Briggs, R.J.

The Heavy Ion Fusion Science Virtual National Laboratory (HIFS-VNL), a collaborationof LBNL, LLNL, and PPPL, has achieved 60-fold pulse compression of ion beams on the Neutralized Drift Compression eXperiment (NDCX) at LBNL. In NDCX, a ramped voltage pulse from an induction cell imparts a velocity"tilt" to the beam; the beam's tail then catches up with its head in a plasma environment that provides neutralization. The HIFS-VNL's mission is to carry out studies of Warm Dense Matter (WDM) physics using ion beams as the energy source; an emerging thrust is basic target physics for heavy ion-driven Inertial Fusion Energy (IFE). Thesemore » goals require an improved platform, labeled NDCX-II. Development of NDCX-II at modest cost was recently enabled by the availability of induction cells and associated hardware from the decommissioned Advanced Test Accelerator (ATA) facility at LLNL. Our initial physics design concept accelerates a ~;;30 nC pulse of Li+ ions to ~;;3 MeV, then compresses it to ~;;1 ns while focusing it onto a mm-scale spot. It uses the ATA cells themselves (with waveforms shaped by passive circuits) to impart the final velocity tilt; smart pulsers provide small corrections. The ATA accelerated electrons; acceleration of non-relativistic ions involves more complex beam dynamics both transversely and longitudinally. We are using analysis, an interactive one-dimensional kinetic simulation model, and multidimensional Warp-code simulations to develop the NDCX-II accelerator section. Both LSP and Warp codes are being applied to the beam dynamics in the neutralized drift and final focus regions, and the plasma injection process. The status of this effort is described.« less

Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase.

PubMed

Chen, Mengbin; Chou, Wayne K W; Al-Lami, Naeemah; Faraldos, Juan A; Allemann, Rudolf K; Cane, David E; Christianson, David W

2016-05-24

Aristolochene synthase (ATAS) is a high-fidelity terpenoid cyclase that converts farnesyl diphosphate exclusively into the bicyclic hydrocarbon aristolochene. Previously determined crystal structures of ATAS complexes revealed trapped active site water molecules that could potentially interact with catalytic intermediates: water "w" hydrogen bonds with S303 and N299, water molecules "w1" and "w2" hydrogen bond with Q151, and a fourth water molecule coordinates to the Mg(2+)C ion. There is no obvious role for water in the ATAS mechanism because the enzyme exclusively generates a hydrocarbon product. Thus, these water molecules are tightly controlled so that they cannot react with carbocation intermediates. Steady-state kinetics and product distribution analyses of eight ATAS mutants designed to perturb interactions with active site water molecules (S303A, S303H, S303D, N299A, N299L, N299A/S303A, Q151H, and Q151E) indicate relatively modest effects on catalysis but significant effects on sesquiterpene product distributions. X-ray crystal structures of S303A, N299A, N299A/S303A, and Q151H mutants reveal minimal perturbation of active site solvent structure. Seven of the eight mutants generate farnesol and nerolidol, possibly resulting from addition of the Mg(2+)C-bound water molecule to the initially formed farnesyl cation, but no products are generated that would suggest enhanced reactivity of other active site water molecules. However, intermediate germacrene A tends to accumulate in these mutants. Thus, apart from the possible reactivity of Mg(2+)C-bound water, active site water molecules in ATAS are not directly involved in the chemistry of catalysis but instead contribute to the template that governs the conformation of the flexible substrate and carbocation intermediates.

Influence of antibody profile in clinical features and prognosis in a cohort of Spanish patients with systemic sclerosis.

PubMed

Iniesta Arandia, Nerea; Simeón-Aznar, Carmen Pilar; Guillén Del Castillo, Alfredo; Colunga Argüelles, Dolores; Rubio-Rivas, Manuel; Trapiella Martínez, Luis; García Hernández, Francisco José; Sáez Comet, Luis; Egurbide Arberas, María Victoria; Ortego-Centeno, Norberto; Freire, Mayka; Marí Alfonso, Begoña; Vargas Hitos, José Antonio; Ríos Blanco, Juan José; Todolí Parra, José Antonio; Rodríguez-Carballeira, Monica; Marín Ballvé, Adela; Chamorro Fernández, Antonio Javier; Pla Salas, Xavier; Madroñero Vuelta, Ana Belen; Ruiz Muñoz, Manuel; Fonollosa Pla, Vicent; Espinosa, Gerard

2017-01-01

To assess the clinical manifestations and prognosis of Spanish patients with systemic sclerosis (SSc) according to their immunological profile. From the Spanish Scleroderma Study Group or RESCLE (Registro de ESCLErodermia as Spanish nomenclature) Registry we selected those patients in which anti-centromere (ACA), anti-topoisomerase I (ATA), and anti-RNA polymerase III (ARA) antibodies had been determined, and a single positivity for each SSc specific antibody was detected. Demographic, clinical, laboratory, and survival data were compared according to the serologic status of these antibodies. Overall, 209 SSc patients were included. In 128 (61%) patients ACA was the only positive antibody, 46 (22%) were only positive for ATA, and 35 (17%) for ARA. Of note, the three groups were mutually exclusive. In univariate analysis, patients with ACA presented more frequently limited cutaneous SSc (lcSSc) (p<0.001), whereas diffuse cutaneous SSc (dcSSc) was the most frequent subtype in patients with ATA (54%) and ARA (62%) (both p<0.001). Positive patients for ARA showed the highest prevalence of joint involvement (p<0.001) and those from ATA group had a higher prevalence of interstitial lung disease (ILD) (p<0.001). Scleroderma renal crisis was more frequent in the ARA group (p<0.001). In multivariate analysis, ACA were associated with female gender and were protective for dcSSc and ILD. ATA were found to be protective for lcSSc and they were independently associated with interstitial reticular pattern. ARA positivity was independently associated with dcSSc. We did not find differences in mortality between the three groups. In Spanish SSc patients, the presence of SSc specific antibodies conferred a distinctive clinical profile.

Superiority of delayed risk stratification in differentiated thyroid cancer after total thyroidectomy and radioactive iodine ablation.

PubMed

Hong, Chae Moon; Lee, Won Kee; Jeong, Shin Young; Lee, Sang-Woo; Ahn, Byeong-Cheol; Lee, Jaetae

2014-11-01

The aim of this study was to validate the effectiveness of delayed risk stratification (DRS) in predicting structural progression and compare the predictive value of American Thyroid Association (ATA) risk stratification with that of DRS in patients with differentiated thyroid cancer (DTC). A total of 398 patients with DTC who underwent surgery followed by radioactive iodine ablation were enrolled. Patients were categorized as having excellent response, acceptable response, biochemical incomplete response, or structural incomplete response at 8-15 months' evaluation after radioactive iodine ablation for DRS. Effectiveness of DRS was evaluated according to structural progression-free survival (PFS; median follow-up, 10.7 years). A total of 229 patients (57.5%) were classified as having excellent response, 78 (19.6%) as having acceptable response, 62 (15.6%) as having biochemical incomplete response, and 29 patients (7.3%) as having structural incomplete response. After DRS, 60.2% of intermediate-risk patients and 20.5% of high-risk patients were shifted to the excellent response category. Sixty-nine patients (17.3%) showed structural progression. DRS showed statistical difference in PFS (hazard ratio, 4.268; 95% confidence interval, 3.258-5.477; P<0.001). In multivariate analysis of ATA risk stratification and DRS, DRS was significantly associated with PFS (hazard ratio, 4.383; 95% confidence interval, 3.250-5.912; P<0.001), but ATA risk stratification was not. There was no significant difference in deviances between the use of DRS alone and the use of both DRS and ATA risk stratification (χ=0.103, d.f.=1, P=0.748). DRS is superior to ATA risk stratification in predicting structural disease progression for DTC patients.

Can quaternary ammonium methacrylates inhibit matrix MMPs and cathepsins?

PubMed Central

Tezvergil-Mutluay, Arzu; Agee, Kelli A.; Mazzoni, Annalisa; Carvalho, Ricardo M.; Carrilho, Marcela; Tersariol, Ivarne L.; Nascimento, Fabio D.; Imazato, Satoshi; Tjäderhane, Leo; Breschi, Lorenzo; Tay, Franklin R; Pashley, David H.

2014-01-01

Objective Dentin matrices release ICTP and CTX fragments during collagen degradation. ICTP fragments are known to be produced by MMPs. CTX fragments are thought to come from cathepsin K activity. The purpose of this study was to determine if quaternary methacrylates (QAMs) can inhibit matrix MMPs and cathepsins. Methods Dentin beams were demineralizated, and dried to constant weight. Beams were incubated with rh-cathepsin B, K, L or S for 24 h at pH 7.4 to identify which cathepsins release CTX at neutral pH. Beams were dipped in ATA, an antimicrobial QAM to determine if it can inhibit dentin matrix proteases. Other beams were dipped in another QAM (MDPB) to determine if it produced similar inhibition of dentin proteases. Results Only beams incubated with cathepsin K lost more dry mass than the controls and released CTX. Dentin beams dipped in ATA and incubated for 1 week at pH 7.4, showed a concentration-dependent reduction in weight-loss. There was no change in ICTP release from control values, meaning that ATA did not inhibit MMPs. Media concentrations of CTX fell significantly at 15 wt% ATA indicating that ATA inhibits capthesins. Beams dipped in increasing concentrations of MDPB lost progressively less mass, showing that MDPB is a protease-inhibitor. ICTP released from controls or beams exposed to low concentrations were the same, while 5 or 10% MDPB significantly lowered ICTP production. CTX levels were strongly inhibited by 2.5–10% MDPB, indicating that MDPB is a potent inhibitor of both MMPs and cathepsin K. Significance CTX seems to be released from dentin matrix only by cathepsin K. MMPs and cathepsin K and B may all contribute to matrix degradation. PMID:25467953

Increasing Fleet Readiness Through Improved Distance Support

DTIC Science & Technology

2013-03-01

gis tic s D ata Pro ce ss  Tra ini ng  Da ta An aly ze  Da ta An...Format Fleet Maintenance Formatted Data /sData F.2.2 • ... Fleet Support Infrastructure Data ~ Formatted Trainin~ ata l Obtain and Format Fleet...system either by using a form or a spreadsheet F.2.2 Obtain Data from Fleet Recorded System Performance Data is downloaded from ship either manually

USSR Report, Life Sciences Biomedical and Behavioral Sciences.

DTIC Science & Technology

1983-09-13

created by the lengthy pro- cesses of evolution and selection, as well as methods for selecting and evaluating plants at the first stages of the...27 May 83) 17 Soviets-American Symposium in Alma-Ata on Plant Proteins and Nutrition (N. Idrisov? KAZAKHSTANSKAYA PRAVDA, 26 Feb 83).., 19...MIKROBIOLOGIYA, Nov-Dec 82),.,,. 38 MOLECULAR BIOLOGY New Research Institute of Plant Molecular Biology and Biochemistry in Alma-Ata (Murat

Australia Ama Ata Aidoo's Diagnose and Representation of the Dilemma of the African American Diaspora in Her Play "Dilemma of a Ghost"

ERIC Educational Resources Information Center

Al-Khafaji, Ammar Shamil Kadhim

2018-01-01

The research investigates in details about the influence of cultural differences in Postcolonial Ghana as presented in Ama Ata Aidoo's "Dilemma of a Ghost". The play centers on the cross cultural marriage of young couple; Ato Yawson, a Ghanaian who recently completed his studies in the United States and returns home, and Eulali, his…

Wide Field Radio Transient Surveys

NASA Astrophysics Data System (ADS)

Bower, Geoffrey

2011-04-01

The time domain of the radio wavelength sky has been only sparsely explored. Nevertheless, serendipitous discovery and results from limited surveys indicate that there is much to be found on timescales from nanoseconds to years and at wavelengths from meters to millimeters. These observations have revealed unexpected phenomena such as rotating radio transients and coherent pulses from brown dwarfs. Additionally, archival studies have revealed an unknown class of radio transients without radio, optical, or high-energy hosts. The new generation of centimeter-wave radio telescopes such as the Allen Telescope Array (ATA) will exploit wide fields of view and flexible digital signal processing to systematically explore radio transient parameter space, as well as lay the scientific and technical foundation for the Square Kilometer Array. Known unknowns that will be the target of future transient surveys include orphan gamma-ray burst afterglows, radio supernovae, tidally-disrupted stars, flare stars, and magnetars. While probing the variable sky, these surveys will also provide unprecedented information on the static radio sky. I will present results from three large ATA surveys (the Fly's Eye survey, the ATA Twenty CM Survey (ATATS), and the Pi GHz Survey (PiGSS)) and several small ATA transient searches. Finally, I will discuss the landscape and opportunities for future instruments at centimeter wavelengths.

The Development of a Portable Hard Disk Encryption/Decryption System with a MEMS Coded Lock

PubMed Central

Zhang, Weiping; Chen, Wenyuan; Tang, Jian; Xu, Peng; Li, Yibin; Li, Shengyong

2009-01-01

In this paper, a novel portable hard-disk encryption/decryption system with a MEMS coded lock is presented, which can authenticate the user and provide the key for the AES encryption/decryption module. The portable hard-disk encryption/decryption system is composed of the authentication module, the USB portable hard-disk interface card, the ATA protocol command decoder module, the data encryption/decryption module, the cipher key management module, the MEMS coded lock controlling circuit module, the MEMS coded lock and the hard disk. The ATA protocol circuit, the MEMS control circuit and AES encryption/decryption circuit are designed and realized by FPGA(Field Programmable Gate Array). The MEMS coded lock with two couplers and two groups of counter-meshing-gears (CMGs) are fabricated by a LIGA-like process and precision engineering method. The whole prototype was fabricated and tested. The test results show that the user's password could be correctly discriminated by the MEMS coded lock, and the AES encryption module could get the key from the MEMS coded lock. Moreover, the data in the hard-disk could be encrypted or decrypted, and the read-write speed of the dataflow could reach 17 MB/s in Ultra DMA mode. PMID:22291566

Measuring Fluctuating Pressure Levels and Vibration Response in a Jet Plume

NASA Technical Reports Server (NTRS)

Osterholt, Douglas J.; Knox, Douglas M.

2011-01-01

The characterization of loads due to solid rocket motor plume impingement allows for moreaccurate analyses of components subjected to such an environment. Typically, test verification of predicted loads due to these conditions is widely overlooked or unsuccessful. ATA Engineering, Inc., performed testing during a solid rocket motor firing to obtain acceleration and pressure responses in the hydrodynamic field surrounding the jet plume. The test environment necessitated a robust design to facilitate measurements being made in close proximity to the jet plume. This paper presents the process of designing a test fixture and an instrumentation package that could withstand the solid rocket plume environment and protect the required instrumentation.

Il progetto Sole, cielo, ambiente

NASA Astrophysics Data System (ADS)

Guerrieri, Maria Antonietta

2006-04-01

A.T.A. (Tusculan Astronomy Association), with the financial support of the District of Rome, carried out an educational project in five high schools. After a theoretic introduction about the Sun, its physics and its interaction with the Earth, some A.T.A. members instructed the students in using the telescope to observe and photograph sunspots. All the schools collaborated in shooting the images of sunspots and in the final analysis and elaboration of data.

Auto-antibodies to Receptor Tyrosine Kinases TrkA, TrkB and TrkC in Patients with Chronic Chagas’ Disease

PubMed Central

Lu, B.; Petrola, Z.; Luquetti, A. O.; PereiraPerrin, M.

2010-01-01

The Chagas’ disease parasite Trypanosoma cruzi promotes survival and differentiation of neurones by binding and activating nerve growth factor (NGF) receptor TrkA. The functional mimic of NGF in T. cruzi is a surface-bound and shed immunogenic protein [neurotrophic factor/trans-sialidase (TS)], which raised the possibility that immune response to T. cruzi in general and to neurotrophic factor/TS in particular leads to loss of immunological tolerance to host NGF and/or the NGF-binding partner TrkA. In testing this hypothesis, we found that sera of individuals with chronic Chagas’ disease bear unique IgG2 autoantibodies that bind TrkA and TrkA family members TrkB and TrkC (ATA). Binding of ATA to Trk receptors is specific because the autoantibodies did not cross-react with five other growth factor receptors, NGF and other neurotrophins, and T. cruzi. Thus, individuals with chronic Chagas’ disease produce unique antibodies that react with pan-Trk receptors, one of which (TrkA) T. cruzi exploits to inhibit host cell apoptosis and to promote cellular invasion. PMID:18410251

Randomized, Sham-Controlled, Feasibility Trial of Hyperbaric Oxygen for Service Members With Postconcussion Syndrome: Cognitive and Psychomotor Outcomes 1 Week Postintervention.

PubMed

Walker, William C; Franke, Laura Manning; Cifu, David X; Hart, Brett B

2014-06-01

Background Mild traumatic brain injury (mTBI) and residual postconcussion syndrome (PCS) are common among combatants of the recent military conflicts in Iraq and Afghanistan. Hyperbaric oxygen (HBO2) is a proposed treatment but has not been rigorously studied for this condition. Objectives In a secondary analysis, examine for possible effects on psychomotor (balance and fine motor) and cognitive performance 1 week after an HBO2 intervention in service members with PCS after mTBI. Methods A randomized, double-blind, sham control, feasibility trial comparing pretreatment and posttreatment was conducted in 60 male active-duty marines with combat-related mTBI and PCS persisting for 3 to 36 months. Participants were randomized to 1 of 3 preassigned oxygen fractions (10.5%, 75%, or 100%) at 2.0 atmospheres absolute (ATA), resulting in respective groups with an oxygen exposure equivalent to (1) breathing surface air (Sham Air), (2) 100% oxygen at 1.5 ATA (1.5 ATAO2), and (3) 100% oxygen at 2.0 ATA (2.0 ATAO2). Over a 10-week period, participants received 40 hyperbaric chamber sessions of 60 minutes each. Outcome measures, including computerized posturography (balance), grooved pegboard (fine motor speed/dexterity), and multiple neuropsychological tests of cognitive performance, were collected preintervention and 1-week postintervention. Results Despite the multiple sensitive cognitive and psychomotor measures analyzed at an unadjusted 5% significance level, this study demonstrated no immediate postintervention beneficial effect of exposure to either 1.5 ATAO2 or 2.0 ATAO2 compared with the Sham Air intervention. Conclusions These results do not support the use of HBO2 to treat cognitive, balance, or fine motor deficits associated with mTBI and PCS. © The Author(s) 2013.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Friedman, A; Barnard, J J; Briggs, R J

The Heavy Ion Fusion Science Virtual National Laboratory (HIFS-VNL), a collaboration of LBNL, LLNL, and PPPL, has achieved 60-fold pulse compression of ion beams on the Neutralized Drift Compression eXperiment (NDCX) at LBNL. In NDCX, a ramped voltage pulse from an induction cell imparts a velocity 'tilt' to the beam; the beam's tail then catches up with its head in a plasma environment that provides neutralization. The HIFS-VNL's mission is to carry out studies of warm dense matter (WDM) physics using ion beams as the energy source; an emerging thrust is basic target physics for heavy ion-driven inertial fusion energymore » (IFE). These goals require an improved platform, labeled NDCX-II. Development of NDCX-II at modest cost was recently enabled by the availability of induction cells and associated hardware from the decommissioned advanced test accelerator (ATA) facility at LLNL. Our initial physics design concept accelerates an {approx} 30 nC pulse of Li{sup +} ions to {approx} 3 MeV, then compresses it to {approx} 1 ns while focusing it onto a mm-scale spot. It uses the ATA cells themselves (with waveforms shaped by passive circuits) to impart the final velocity tilt; smart pulsers provide small corrections. The ATA accelerated electrons; acceleration of non-relativistic ions involves more complex beam dynamics both transversely and longitudinally. We are using an interactive one-dimensional kinetic simulation model and multidimensional Warp-code simulations to develop the NDCX-II accelerator section. Both LSP and Warp codes are being applied to the beam dynamics in the neutralized drift and final focus regions, and the plasma injection process. The status of this effort is described.« less

What is the gold standard for comprehensive interinstitutional communication of perioperative information for thyroid cancer patients? A comparison of existing electronic health records with the current American Thyroid Association recommendations.

PubMed

Dos Reis, Laura L; Tuttle, R Michael; Alon, Eran; Bergman, Donald A; Bernet, Victor; Brett, Elise M; Cobin, Rhoda; Doherty, Gerard; Harris, Jeffrey R; Klopper, Joshua; Lee, Stephanie L; Lupo, Mark; Milas, Mira; Machac, Josef; Mechanick, Jeffrey I; Orloff, Lisa; Randolph, Gregory; Ross, Douglas S; Smallridge, Robert C; Terris, David James; Tufano, Ralph P; Mehra, Saral; Scherl, Sophie; Clain, Jason B; Urken, Mark L

2014-10-01

Appropriate management of well-differentiated thyroid cancer requires treating clinicians to have access to critical elements of the patient's presentation, surgical management, postoperative course, and pathologic assessment. Electronic health records (EHRs) provide an effective method for the storage and transmission of patient information, although most commercially available EHRs are not intended to be disease-specific. In addition, there are significant challenges for the sharing of relevant clinical information when providers involved in the care of a patient with thyroid cancer are not connected by a common EHR. In 2012, the American Thyroid Association (ATA) defined the critical elements for optimal interclinician communication in a position paper entitled, "The Essential Elements of Interdisciplinary Communication of Perioperative Information for Patients Undergoing Thyroid Cancer Surgery." We present a field-by-field comparison of the ATA's essential elements as applied to three contemporary electronic reporting systems: the Thyroid Surgery e-Form from Memorial Sloan-Kettering Cancer Center (MSKCC), the Alberta WebSMR from the University of Calgary, and the Thyroid Cancer Care Collaborative (TCCC). The MSKCC e-form fulfills 21 of 32 intraoperative fields and includes an additional 14 fields not specifically mentioned in the ATA's report. The Alberta WebSMR fulfills 45 of 82 preoperative and intraoperative fields outlined by the ATA and includes 13 additional fields. The TCCC fulfills 117 of 120 fields outlined by the ATA and includes 23 additional fields. Effective management of thyroid cancer is a highly collaborative, multidisciplinary effort. The patient information that factors into clinical decisions about thyroid cancer is complex. For these reasons, EHRs are particularly favorable for the management of patients with thyroid cancer. The MSKCC Thyroid Surgery e-Form, the Alberta WebSMR, and the TCCC each meet all of the general recommendations for effective reporting of the specific domains that they cover in the management of thyroid cancer, as recommended by the ATA. However, the TCCC format is the most comprehensive. The TCCC is a new Web-based disease-specific database to enhance communication of patient information between clinicians in a Health Insurance Portability and Accountability Act (HIPAA)-compliant manner. We believe the easy-to-use TCCC format will enhance clinician communication while providing portability of thyroid cancer information for patients.

Deployable Engine Air Brake

NASA Technical Reports Server (NTRS)

2014-01-01

On approach, next-generation aircraft are likely to have airframe noise levels that are comparable to or in excess of engine noise. ATA Engineering, Inc. (ATA) is developing a novel quiet engine air brake (EAB), a device that generates "equivalent drag" within the engine through stream thrust reduction by creating a swirling outflow in the turbofan exhaust nozzle. Two Phase II projects were conducted to mature this technology: (1) a concept development program (CDP) and (2) a system development program (SDP).

Hyperbaric oxygen: B-level evidence in mild traumatic brain injury clinical trials.

PubMed

Figueroa, Xavier A; Wright, James K

2016-09-27

First, to demonstrate that B-level evidence exists for the use of hyperbaric oxygen therapy (HBOT) as an effective treatment in mild to moderate traumatic brain injury/persistent postconcussion syndrome (mTBI/PPCS). Second, to alert readers and researchers that currently used pressurized air controls (≥21% O2, >1.0 ATA) are therapeutically active and cannot be utilized as sham controls without further validation. Review of published, peer-reviewed articles of HBOT prospective and controlled clinical trials of mTBI/PPCS symptoms. Published results demonstrate that HBOT is effective in the treatment of mTBI/PPCS symptoms. Doses of oxygen that are applied at ≥21% O2 and at pressures of >1.0 ATA produce improvements from baseline measures. Some of the recently published clinical trials are mischaracterized as sham-controlled clinical trials (i.e., sham = 21% O2/1.2-1.3 ATA), but are best characterized as dose-varying (variation in oxygen concentration, pressure applied, or both) clinical trials. Hyperbaric oxygen and hyperbaric air have demonstrated therapeutic effects on mTBI/PPCS symptoms and can alleviate posttraumatic stress disorder symptoms secondary to a brain injury in 5 out of 5 peer-reviewed clinical trials. The current use of pressurized air (1.2-1.3 ATA) as a placebo or sham in clinical trials biases the results due to biological activity that favors healing. © 2016 American Academy of Neurology.

Targeted Feedback in the Milestones Era: Utilization of the Ask-Tell-Ask Feedback Model to Promote Reflection and Self-Assessment.

PubMed

French, Judith C; Colbert, Colleen Y; Pien, Lily C; Dannefer, Elaine F; Taylor, Christine A

2015-01-01

The Accreditation Council for Graduate Medical Education's Milestones Project focuses trainee education on the formation of valued behaviors and skills believed to be necessary for trainees to become independent practitioners. The development and refinement of behaviors and skills outlined within the milestones will require learners to monitor, reflect, and assess their own performance over time. External feedback provides an opportunity for learners to recalibrate their self-assessments, thereby enabling them to develop better self-monitoring and self-assessment skills. Yet, feedback to trainees is frequently generic, such as "great job," "nice work," or "you need to read more." In this article, we describe a feedback model that faculty can use to provide specific feedback, while increasing accountability for learners. We offer practical examples of its use in a variety of settings in the milestone era. The Ask-Tell-Ask (ATA) patient communication skills strategy, which was adapted for use as a trainee feedback model 10 years ago at our institution, is a learner-centered approach for reinforcing and modifying behaviors. The model is efficient, promotes learner accountability, and helps trainees develop reflection and self-assessment skills. A feedback agreement further enhances ATA by establishing a shared understanding of goals for the educational encounter. The ATA feedback model, combined with a feedback agreement, encourages learners to self-identify strengths and areas for improvement, before receiving feedback. Personal monitoring, reflection, self-assessment, and increased accountability make ATA an ideal learner-centered feedback model for the milestones era, which focuses on performance improvement over time. We believe the introduction of the ATA feedback model in surgical training programs is a step in the right direction towards meaningful programmatic culture change. Copyright © 2015 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

King Ata Tag Mountain Range, western China as seen by STS-66 Atlantis

NASA Image and Video Library

1994-11-14

The northwest-southeast trending, snow-covered, linear mountain range is the King Ata Tag Mountain, located in extreme western most China. Highest peaks are just over 20,100 feet above sea level. The town or village of Muji is located in the largest river valley that is south of this range of mountains. This area includes part of the country of Tajikistan. The center point of the photo is approximately 39.30 degrees north and 74.30 degrees easth.

Chemical tests: Propellants, Gases, and Metals

DTIC Science & Technology

1975-12-11

14 Determination of Chromium and Nickel in Stainless Steels by X-ray Spectroscopy 80 5. 15 Determination of Furfural in Furfuryl Alcohol by Infrared...and b for nickel. 81 TOP 5-2-5S5 11 December 1975 5. 15 l)eterminazocn of Furfural in Furfury iAlcohol by 1 nfrared Spectroscoov 5. 15. 1 Objective...To determine the furfural content of furfuryl alcohol. Fart. ryl alcohol is manufactured from furfural atA elevated pressure and temperatare; resi.dual

Effects of He-O2 Breathing during Experimental Decompression Sickness Following Air Dives

DTIC Science & Technology

1987-03-01

sickness (DCS1 and venous air embolism were studied . Fifteen anestht zed dogs were mechanically ventilated and subjected to repeated air dives until...animals with He-0 2 during venous air embolism worsens pulmonary hypertension and hypoxemia (9). To test this hypothesis, we studied the effects of He...additional animals (air embolism group), gas switching was studied during venous air embolism at I ATA. These animals were anesthetized and instnmented as

Prevalence of hypothyroidism during pregnancy in a highly specialised referral centre in Mexico.

PubMed

López-Muñoz, Eunice; Ibarra-Avalos, Jorge Antonio; Chan-Verdugo, Rosario Guadalupe; Mateos-Sánchez, Leovigildo; Sánchez-Rodríguez, Olivia

2016-11-01

In order to determine the prevalence of overt and subclinical hypothyroidism, and isolated hypothyroxinemia during pregnancy, thyroid hormone reference values established by UMAE HGO4, IMSS in Mexico City and those suggested by the American Thyroid Association (ATA) were used. All pregnant patients, whose thyroid function was measured and whose pregnancy was monitored and resolved in UMAE HGO4, IMSS from 1 January to 31 December 2013, were included. Significant differences (p = .00419) were observed in the frequency of subclinical hypothyroidism, being higher when using ATA criteria (18.21% vs. 9.66%). The prevalence rate (UMAE HGO4 vs. ATA) for overt hypothyroidism was 1.11 vs. 1.63, for subclinical hypothyroidism 0.84 vs. 1.41 and for isolated hypothyroxinemia 3.17 vs. 2.79 per 1000 consults during the study period. Independently of prevalence rate, it is essential to provide information on the possible risks involved in pregnancy to all women of childbearing age at the time of hypothyroidism diagnosis.

Whole-genome sequencing of Atacama skeleton shows novel mutations linked with dysplasia

PubMed Central

Bhattacharya, Sanchita; Li, Jian; Sockell, Alexandra; Kan, Matthew J.; Bava, Felice A.; Chen, Shann-Ching; Ávila-Arcos, María C.; Ji, Xuhuai; Smith, Emery; Asadi, Narges B.; Lachman, Ralph S.; Lam, Hugo Y.K.; Bustamante, Carlos D.; Butte, Atul J.; Nolan, Garry P.

2018-01-01

Over a decade ago, the Atacama humanoid skeleton (Ata) was discovered in the Atacama region of Chile. The Ata specimen carried a strange phenotype—6-in stature, fewer than expected ribs, elongated cranium, and accelerated bone age—leading to speculation that this was a preserved nonhuman primate, human fetus harboring genetic mutations, or even an extraterrestrial. We previously reported that it was human by DNA analysis with an estimated bone age of about 6–8 yr at the time of demise. To determine the possible genetic drivers of the observed morphology, DNA from the specimen was subjected to whole-genome sequencing using the Illumina HiSeq platform with an average 11.5× coverage of 101-bp, paired-end reads. In total, 3,356,569 single nucleotide variations (SNVs) were found as compared to the human reference genome, 518,365 insertions and deletions (indels), and 1047 structural variations (SVs) were detected. Here, we present the detailed whole-genome analysis showing that Ata is a female of human origin, likely of Chilean descent, and its genome harbors mutations in genes (COL1A1, COL2A1, KMT2D, FLNB, ATR, TRIP11, PCNT) previously linked with diseases of small stature, rib anomalies, cranial malformations, premature joint fusion, and osteochondrodysplasia (also known as skeletal dysplasia). Together, these findings provide a molecular characterization of Ata's peculiar phenotype, which likely results from multiple known and novel putative gene mutations affecting bone development and ossification. PMID:29567674

American Thyroid Association Guidelines on the Management of Thyroid Nodules and Differentiated Thyroid Cancer Task Force Review and Recommendation on the Proposed Renaming of Encapsulated Follicular Variant Papillary Thyroid Carcinoma Without Invasion to Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features.

PubMed

Haugen, Bryan R; Sawka, Anna M; Alexander, Erik K; Bible, Keith C; Caturegli, Patrizio; Doherty, Gerard M; Mandel, Susan J; Morris, John C; Nassar, Aziza; Pacini, Furio; Schlumberger, Martin; Schuff, Kathryn; Sherman, Steven I; Somerset, Hilary; Sosa, Julie Ann; Steward, David L; Wartofsky, Leonard; Williams, Michelle D

2017-04-01

American Thyroid Association (ATA) leadership asked the ATA Thyroid Nodules and Differentiated Thyroid Cancer Guidelines Task Force to review, comment on, and make recommendations related to the suggested new classification of encapsulated follicular variant papillary thyroid carcinoma (eFVPTC) without capsular or vascular invasion to noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). The task force consists of members from the 2015 guidelines task force with the recusal of three members who were authors on the paper under review. Four pathologists and one endocrinologist were added for this specific review. The manuscript proposing the new classification and related literature were assessed. It is recommended that the histopathologic nomenclature for eFVPTC without invasion be reclassified as a NIFTP, given the excellent prognosis of this neoplastic variant. This is a weak recommendation based on moderate-quality evidence. It is also noted that prospective studies are needed to validate the observed patient outcomes (and test performance in predicting thyroid cancer outcomes), as well as implications on patients' psychosocial health and economics.

Role of shell diffusion area in incubating eggs at simulated high altitude.

PubMed

Weiss, H S

1978-10-01

Embryonic development is inhibited when eggs are incubated at 9,100 m (0.3 atm) despite a normoxic environment. The problem apparently relates to respiratory gas exchange occurring by diffusion through gas-filled pores in the shell. Gaseous flux is therefore inversely proportional to ambient pressure and is affected by the physical characteristics of the ambient gas (Chapman-Enskog equation). Excess loss of H2O and CO2 occurs in eggs incubating at altitude and could be detrimental. Such increased loss should be correctable by decreasing diffusion area. This was tested by progressively increasing coverage of the shell with paraffin and incubating at simulated 0.3 ATA (225 Torr) in 100% O2. Uncoated eggs failed to hatch, but numbers of chicks increased with increased coverage. Maximum hatch was an extrapolated 90% of controls at 69% shell coverage. With further coverage, hatch size decreased. Egg weight loss, and estimate of H2O diffusion, was around three times controls in uncoated eggs but decreased linearly with paraffin coverage, reaching near normal at maximum hatch. Reduction of diffusion area to 0.3 normal at maximum hatch generally balanced the increased flux predicted for 0.3 ATA.

Laser Cooling and Trapping of Atoms and Particles

DTIC Science & Technology

1992-01-16

AFOSR-88-0349 .THOM Professor Steven Chu 7. p G O3AWuT.o NM(s) =amiss(,s) ’ ,& . 6o* oftU wm, Stanford University P Mum.. Dept of Physics Stanford CA...provided that small dielectric spheres are attached to the ends of the DNA. We are currently testing many of the basic tenants of polymer physics at...A 17,000 word article for the Encyclopedia Britannica covering all aspects of "Spectroscopy", shorter entries for the Encyclopedia of Physics and

Translational Control in Bone Marrow Failure

DTIC Science & Technology

2014-04-01

expressing the ATG2 ORF and the ATG3 ORF, we also evaluated the ATG> GTG mutation, which produces all 3 internal ORFs. (We did not test ORF4...expressing shortened forms of NE reduced clonogenic capacity (Fig. 4 of Tidwell et al.). When comparing the shorter isoforms of NE to each other, the GTG ...mutated from ATG to either ATA or GTG , shortened forms of NE were evident (Figure 2, c.3G.A, c.1A.G). When the highly conserved nucleotide in the Kozak

A Structural Finite Element Model for Lamellar Unit of Aortic Media Indicates Heterogeneous Stress Field After Collagen Recruitment

PubMed Central

Thunes, James R.; Pal, Siladitya; Fortunato, Ronald N.; Phillippi, Julie A.; Gleason, Thomas G.; Vorp, David A.; Maiti, Spandan

2016-01-01

Incorporation of collagen structural information into the study of biomechanical behavior of ascending thoracic aortic (ATA) wall tissue should provide better insight into the pathophysiology of ATA. Structurally motivated constitutive models that include fiber dispersion and recruitment can successfully capture overall mechanical response of the arterial wall tissue. However, these models cannot examine local microarchitectural features of the collagen network, such as the effect of fiber disruptions and interaction between fibrous and non-fibrous components, which may influence emergent biomechanical properties of the tissue. Motivated by this need, we developed a finite element based three-dimensional structural model of the lamellar units of the ATA media that directly incorporates the collagen fiber microarchitecture. The fiber architecture was computer generated utilizing network features, namely fiber orientation distribution, intersection density and areal concentration, obtained from image analysis of multiphoton microscopy images taken from human aneurysmal ascending thoracic aortic media specimens with bicuspid aortic valve (BAV) phenotype. Our model reproduces the typical J-shaped constitutive response of the aortic wall tissue. We found that the stress state in the non-fibrous matrix was homogeneous until the collagen fibers were recruited, but became highly heterogeneous after that event. The degree of heterogeneity was dependent upon local network architecture with high stresses observed near disrupted fibers. The magnitude of non-fibrous matrix stress at higher stretch levels was negatively correlated with local fiber density. The localized stress concentrations, elucidated by this model, may be a factor in the degenerative changes in aneurysmal ATA tissue. PMID:27113538

High doses of pseudoephedrine hydrochloride accelerate onset of CNS oxygen toxicity seizures in unanesthetized rats.

PubMed

Pilla, R; Held, H E; Landon, C S; Dean, J B

2013-08-29

Pseudoephedrine (PSE) salts (hydrochloride and sulfate) are commonly used as nasal and paranasal decongestants by scuba divers. Anecdotal reports from the Divers Alert Network suggest that taking PSE prior to diving while breathing pure O₂ increases the risk for CNS oxygen toxicity (CNS-OT), which manifests as seizures. We hypothesized that high doses of PSE reduce the latency time to seizure (LS) in unanesthetized rats breathing 5 atmospheres absolute (ATA) of hyperbaric oxygen. Sixty-three male rats were implanted with radio-transmitters that recorded electroencephalogram activity and body temperature. After ≥7-day recovery, and 2 h before "diving", each rat was administered either saline solution (control) or PSE hydrochloride intragastrically at the following doses (mg PSE/kg): 0, 40, 80, 100, 120, 160, and 320. Rats breathed pure O₂ and were dived to 5ATA until the onset of behavioral seizures coincident with neurological seizures. LS was the time elapsed between reaching 5ATA and exhibiting seizures. We observed a significant dose-dependent decrease in the LS at doses of 100-320 mg/kg, whereas no significant differences in LS from control value were observed at doses ≤80 mg/kg. Our findings showed that high doses of PSE accelerate the onset of CNS-OT seizures in unanesthetized rats breathing 5ATA of poikilocapnic hyperoxia. Extrapolating our findings to humans, we conclude that the recommended daily dose of PSE should not be abused prior to diving with oxygen-enriched gas mixes or pure O₂. Copyright © 2013 IBRO. Published by Elsevier Ltd. All rights reserved.

Anterior segment biometry with 2 imaging technologies: very-high-frequency ultrasound scanning versus optical coherence tomography.

PubMed

Piñero, David P; Plaza, Ana Belén; Alió, Jorge L

2008-01-01

To determine the interchangeability of 2 anterior segment imaging systems: a very-high-frequency (VHF) ultrasound scanning system (Artemis 2, Ultralink LLC) and an optical coherence tomography (OCT) system (Visante, Zeiss). Vissum Instituto Oftalmologico de Alicante, Alicante, Spain. This study comprised 20 eyes without pathology or previous surgery. The anterior chamber depth (ACD), central corneal thickness (CCT), angle-to-angle distance (ATA), and the iridocorneal angle size (IAS) at the 0-degree and 180-degree positions were measured with 2 imaging techniques: VHF ultrasound scanning and OCT. Analysis of agreement and interchangeability was performed by the Bland and Altman method. In addition, each measurement was performed 3 times consecutively to determine intrasession repeatability by means of the coefficient of variation (CV) and the intraclass correlation coefficient (ICC). No statistically significant differences were found between imaging techniques in ACD, CCT, or ATA (P>.40). The ranges of agreement were 0.20 mm, 16.11 mum, and 0.80 mm for ACD, CCT, and ATA, respectively. Regarding IAS, no statistically significant differences were found in the nasal (P = .78) or temporal (P = .63) measurements between devices. However, the range of agreement for nasal (14.3 degrees) and temporal (14.90 degrees) values was relevant, indicating the 2 techniques cannot be used interchangeably for IAS measurement. Excellent intrasession repeatability scores were obtained (CV and ICC). The Artemis 2 and the Visante OCT systems provide equivalent and repeatable measurements of the ACD, CCT, and ATA and can be used interchangeably for these purposes.

Whole-genome sequencing of Atacama skeleton shows novel mutations linked with dysplasia.

PubMed

Bhattacharya, Sanchita; Li, Jian; Sockell, Alexandra; Kan, Matthew J; Bava, Felice A; Chen, Shann-Ching; Ávila-Arcos, María C; Ji, Xuhuai; Smith, Emery; Asadi, Narges B; Lachman, Ralph S; Lam, Hugo Y K; Bustamante, Carlos D; Butte, Atul J; Nolan, Garry P

2018-04-01

Over a decade ago, the Atacama humanoid skeleton (Ata) was discovered in the Atacama region of Chile. The Ata specimen carried a strange phenotype-6-in stature, fewer than expected ribs, elongated cranium, and accelerated bone age-leading to speculation that this was a preserved nonhuman primate, human fetus harboring genetic mutations, or even an extraterrestrial. We previously reported that it was human by DNA analysis with an estimated bone age of about 6-8 yr at the time of demise. To determine the possible genetic drivers of the observed morphology, DNA from the specimen was subjected to whole-genome sequencing using the Illumina HiSeq platform with an average 11.5× coverage of 101-bp, paired-end reads. In total, 3,356,569 single nucleotide variations (SNVs) were found as compared to the human reference genome, 518,365 insertions and deletions (indels), and 1047 structural variations (SVs) were detected. Here, we present the detailed whole-genome analysis showing that Ata is a female of human origin, likely of Chilean descent, and its genome harbors mutations in genes ( COL1A1 , COL2A1 , KMT2D , FLNB , ATR , TRIP11 , PCNT ) previously linked with diseases of small stature, rib anomalies, cranial malformations, premature joint fusion, and osteochondrodysplasia (also known as skeletal dysplasia). Together, these findings provide a molecular characterization of Ata's peculiar phenotype, which likely results from multiple known and novel putative gene mutations affecting bone development and ossification. © 2018 Bhattacharya et al.; Published by Cold Spring Harbor Laboratory Press.

Silurian to Early Carboniferous plate tectonic model of Central Europe

NASA Astrophysics Data System (ADS)

Golonka, Jan; Barmuta, Jan; Barmuta, Maria

2014-05-01

The presented plate tectonic model focuses on Silurian to Early Carboniferous evolution of Central Europe with special attention given to the Sudetes region (north and north-east part of the Bohemian Massif). During our studies, we tested alternative models focused on the position of the Armorican terranes, known as the Armorican Terrane Assembly (ATA) (e.g.: Matte, 2001) and tried to refine the existing reconstructions, which describe Armorica as an individual continent during the Late Silurian and Devonian (e.g. Lewandowski, 2003, Winchester, 2002). Our plate tectonic model depict that these small blocks were scattered along the northern margin of Gondwana, where they formed the "Armorican Spour" as suggested by Kroner and Romer (2013). The seaways were present between blocks. Because of the north dipping subduction zone along the southern margin of the Laurussia continent the back-arc basin and island arc were formed. The narrowing of the Rheic ocean led to the complicated collision of Gondwana and Laurussia. Three main stages of this event can be distinguished: (1) collision of the Armorican Spour with the Laurussian island arc, (2) back-arc basin closure, (3) final Gondwana and Laurussian collision. Those stages correlate well with Variscan Subduction Zone System proposed by Kroner and Romer (2013). Interactive modeling performed in GPlates, shows that the presented model is valid from kinematic and geometrical point of view. Kroner U., Romer R., L., 2013, Two plates - many subduction zones: the Variscan orogeny reconsidered. Gondwana Research, 24: 298-329. Lewandowski M., 2003, Assembly of Pangea: Combined paleomagnetic and paleoclimatic approach, Advances in Geophysics, 46: 199-236 Matte P., 2001, The Variscan collage and orogeny (480 290 Ma) and the tectonic definition of the Armorica microplate: a review. Terra Nova, 13: 122¨C128. Winchester J., A., The Pace TMR Network Team, 2002, Palaeozoic amalgamation of Central Europe: new results from recent geological and geophysical investigations, Tectonophysics, 360: 5-21

Validation of the modified 4-tiered categorization system through comparison with the 5-tiered categorization system of the 2015 American Thyroid Association guidelines for classifying small thyroid nodules on ultrasound.

PubMed

Lee, Ji Hye; Han, Kyunghwa; Kim, Eun-Kyung; Moon, Hee Jung; Yoon, Jung Hyun; Park, Vivian Y; Kwak, Jin Young

2017-11-01

The purpose of this study was to validate the modified 4-tiered categorization system and to compare stratification of malignancy risk in small thyroid nodules with the 2015 American Thyroid Association (ATA) management guidelines. From January 2015 to December 2015, 737 thyroid nodules measured ≥ 1 cm and <2 cm were included in this study. Each nodule was assigned a category with the ultrasonographic patterns described by the 2015 ATA guidelines. On univariate analysis, there was no difference of malignancy risk between low suspicion and very low suspicion nodules (P = .584). Therefore, we suggested a modified 4-tiered categorization, which combines very low suspicion and low suspicion nodules into the "revised low suspicion" category. Specificity, positive predictive value (PPV) and accuracy were higher with the modified 4-tiered categorization system (P < .001 for all). The modified 4-tiered categorization system allows more efficient management with better diagnostic performance than the 2015 ATA categorization system in small thyroid nodules. © 2017 Wiley Periodicals, Inc.

Recovery of gold from industrial wastewater by extracellular proteins obtained from a thermophilic bacterium Tepidimonas fonticaldi AT-A2.

PubMed

Han, Yin-Lung; Wu, Jen-Hao; Cheng, Chieh-Lun; Nagarajan, Dillirani; Lee, Ching-Ray; Li, Yi-Heng; Lo, Yung-Chung; Chang, Jo-Shu

2017-09-01

Biosorption has emerged as a promising alternative approach for treating wastewater with dilute metal contents in a green and cost effective way. In this study, extracellular proteins of an isolated thermophilic bacterium (Tepidimonas fonticaldi AT-A2) were used as biosorbent to recover precious metal (i.e., Au) from wastewater. The Au (III) adsorption capacity on the T. fonticaldi AT-A2 proteins was the highest when the pH was set at about 4.0-5.0. The adsorption capacity increased with increasing temperature from 15 to 70°C. Adsorption isotherm studies show that both Langmuir and Freundrich models could describe the adsorption equilibrium. The maximum adsorption capacity of Au (III) at 50°C and pH 5 could reach 9.7mg Au/mg protein. The protein-based biosorbent was also used for the recovery of Au from a wastewater containing 15mg/L of Au, achieving a high adsorption capacity of 1.45mg Au/mg protein and a removal efficiency of 71%. Copyright © 2017 Elsevier Ltd. All rights reserved.

2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis.

PubMed

Ross, Douglas S; Burch, Henry B; Cooper, David S; Greenlee, M Carol; Laurberg, Peter; Maia, Ana Luiza; Rivkees, Scott A; Samuels, Mary; Sosa, Julie Ann; Stan, Marius N; Walter, Martin A

2016-10-01

Thyrotoxicosis has multiple etiologies, manifestations, and potential therapies. Appropriate treatment requires an accurate diagnosis and is influenced by coexisting medical conditions and patient preference. This document describes evidence-based clinical guidelines for the management of thyrotoxicosis that would be useful to generalist and subspecialty physicians and others providing care for patients with this condition. The American Thyroid Association (ATA) previously cosponsored guidelines for the management of thyrotoxicosis that were published in 2011. Considerable new literature has been published since then, and the ATA felt updated evidence-based guidelines were needed. The association assembled a task force of expert clinicians who authored this report. They examined relevant literature using a systematic PubMed search supplemented with additional published materials. An evidence-based medicine approach that incorporated the knowledge and experience of the panel was used to update the 2011 text and recommendations. The strength of the recommendations and the quality of evidence supporting them were rated according to the approach recommended by the Grading of Recommendations, Assessment, Development, and Evaluation Group. Clinical topics addressed include the initial evaluation and management of thyrotoxicosis; management of Graves' hyperthyroidism using radioactive iodine, antithyroid drugs, or surgery; management of toxic multinodular goiter or toxic adenoma using radioactive iodine or surgery; Graves' disease in children, adolescents, or pregnant patients; subclinical hyperthyroidism; hyperthyroidism in patients with Graves' orbitopathy; and management of other miscellaneous causes of thyrotoxicosis. New paradigms since publication of the 2011 guidelines are presented for the evaluation of the etiology of thyrotoxicosis, the management of Graves' hyperthyroidism with antithyroid drugs, the management of pregnant hyperthyroid patients, and the preparation of patients for thyroid surgery. The sections on less common causes of thyrotoxicosis have been expanded. One hundred twenty-four evidence-based recommendations were developed to aid in the care of patients with thyrotoxicosis and to share what the task force believes is current, rational, and optimal medical practice.

[Polymorphism of TNF-alpha (308 A/G), IL-10 (1082 A/G, 819 C/T 592 A/C), IL-6 (174 G/C), and IFN-gamma (874 A/T); genetically conditioned cytokine synthesis level in children with diabetes type 1].

PubMed

Siekiera, Urszula; Jarosz-Chobot, P; Janusz, J; Koehler, Brygida

2002-01-01

Type 1 diabetes is a genetically conditioned autoimmune disease. Genes that account for strong clustering of the disease susceptibility are located within the HLA region. There is also considerable individual variation in the immune response and role of cytokine genes in the disease predisposition. The aim of our research was identification of the genetically controlled TNF-alpha, IL-10, IL-6, IFN-gamma secretion profile in children with diabetes type 1. We have examined 36 children with diabetes type 1 and 36 healthy individuals. DNA was extracted from mononuclear peripheral blood cells. For identification of the cytokine polymorphism PCR-SSP method was used. Patients with diabetes type 1 differ from the group of healthy persons in the cytokine synthesis level and in the cytokine genotypes distribution. Genotype TNF-alpha (A/G) as well as IL-10 (ATA/ATA) was found only in group of children with diabetes but not in the control group. Genotypes IL-10 (GCC/GCC), IL-6 (C/C), IFN-gamma (T/T) were observed with decreased frequency in children with diabetes type 1. No differences between patients and control group in the frequency of IL-10 (GCC/ACC) (GCC/ATA), (ACC/ACC) (ACC/ATA) IL-6 (G/G), (G/C) and IFN-gamma (T/A), (A/A) genotypes were observed. Children with diabetes type 1 were more frequent "high producers" of TNF-alpha and IL-6. It is possible to us molecular method to estimate the genetically controlled immune reactivity. It is a very important immunogenetic factor of the disease predisposition.

Psychomotor Battery Approaches to Performance Prediction and Evaluation in Hyperbaric, Thermal and Vibratory Environments: Annotated Bibliographies and Integrative Review

DTIC Science & Technology

1980-10-01

Psychomotor Battery in the early 1940’s. This effort was a natural extension of the development of the Complex Coordinator in 1929. During World War...to note that manual dexterity has been reported to decrease signif - icantly at 4 ATA when the divers were exercisint aj opposed k.o a significant...each pressure level by means of .a t-test. Results on the manual dexterity task showed that, with the subjects at rest, performance deteriorated signif

Commercial jet fuel quality control

DOE Office of Scientific and Technical Information (OSTI.GOV)

Strauss, K.H.

1995-05-01

The paper discusses the purpose of jet fuel quality control between the refinery and the aircraft. It describes fixed equipment, including various types of filters, and the usefulness and limitations of this equipment. Test equipment is reviewed as are various surveillance procedures. These include the Air Transport Association specification ATA 103, the FAA Advisory Circular 150/5230-4, the International Air Transport Association Guidance Material for Fuel Quality Control and Fuelling Service and the Guidelines for Quality Control at Jointly Operated Fuel Systems. Some past and current quality control problems are briefly mentioned.

Acidogenic pretreatment of wastewaters containing 2-nitrophenol.

PubMed

Jinadasa, K B S N; Mun, C H; Aziz, M A; Ng, W J

2004-01-01

Anaerobic Toxicity Assay (ATA) tests were conducted on acidogenic cultures to assess the feasibility of using acidogenic processes to treat wastewaters containing 2-nitrophenol. Results indicated 2-nitrophenol could be removed with a removal efficiency of more than 98%. 2-aminophenol was identified as the major metabolite of the biotransformation of 2-nitrophenol. Reduction in inhibition potential of acidogenic pretreated effluent was observed in the aerobic process. EC50 values of 2-nitrophenol and 2-aminophenol were found to be 0.065 mM and 1.83 mM respectively.

Estimating airline operating costs

NASA Technical Reports Server (NTRS)

Maddalon, D. V.

1978-01-01

A review was made of the factors affecting commercial aircraft operating and delay costs. From this work, an airline operating cost model was developed which includes a method for estimating the labor and material costs of individual airframe maintenance systems. The model, similar in some respects to the standard Air Transport Association of America (ATA) Direct Operating Cost Model, permits estimates of aircraft-related costs not now included in the standard ATA model (e.g., aircraft service, landing fees, flight attendants, and control fees). A study of the cost of aircraft delay was also made and a method for estimating the cost of certain types of airline delay is described.

The impact of the UGT1A1*60 allele on bilirubin serum concentrations.

PubMed

Pasternak, Amy L; Crews, Kristine R; Caudle, Kelly E; Smith, Colton; Pei, Deqing; Cheng, Cheng; Broeckel, Ulrich; Gaur, Aditya H; Hankins, Jane; Relling, Mary V; Haidar, Cyrine E

2017-01-01

Identify the functional status of the uridine-diphosphate glucuronyl transferase 1A1 (UGT1A1) -3279T>G (*60) variant. Retrospective review of clinically obtained serum bilirubin concentrations in pediatric patients to evaluate the association of the UGT1A1 -3279T>G (*60) variant with bilirubin concentrations and assessed linkage disequilibrium of the UGT1A1 -3279T>G (*60) and A(TA)7TAA (*28) variants. Total bilirubin concentration did not differ between patients who had a UGT1A1*1/*1 diplotype and patients homozygous for the UGT1A1 -3279T>G (*60/*60) variant. Total bilirubin concentration was lower in patients homozygous for the UGT1A1 -3279T>G (*60/*60) variant than in patients homozygous for the UGT1A1 A(TA)7TAA (*28/*28) variant (p < 0.01). The -3279T>G (*60) and A(TA)7TAA (*28) variants were in strong incomplete linkage disequilibrium in both black and white patients. The presence of the UGT1A1 -3279T>G (*60) variant is not associated with increased bilirubin concentrations.

Seasonal variation and source analysis of persistent organic pollutants in the atmosphere over the western Tibetan Plateau.

PubMed

Zhang, Jingyi; Wang, Xiaoping; Gong, Ping; Wang, Chuanfei; Sun, Dianchao

2018-06-08

Over the past few decades, the Tibetan Plateau (TP) region has become gradually contaminated by persistent organic pollutants (POPs). The picture regarding POPs is clear in the central and southern parts of the TP; however, few observational campaigns have focused on the western TP. To clarify the concentrations, seasonal trends and source regions of POPs in the western TP, a first study of POPs in Muztagh Ata (westerly region) and a long-term (5 years) monitoring program in Ngari (transect region influenced by both the Indian monsoon and westerly climate) were conducted. Except for hexachlorobenzene (HCB) and polychlorinated biphenyls (PCBs), relatively low POP levels were observed in the western TP. In Muztagh Ata, dichlorodiphenyltrichloroethanes (DDTs) showed higher concentrations in winter and lower ones in summer, whereas at Ngari, higher DDTs and hexachlorocyclohexanes (HCHs) concentrations were observed in summer as compared with winter. Source diagnosis indicated that Xinjiang and central Asia were the main source regions for POPs in Muztagh Ata and that westerly winds play a key role in transporting POPs from central Asia. No correlation was found between the height of the atmospheric boundary layer and the concentrations of POPs over the TP.

Role of Ultrasound in Predicting Tumor Invasiveness in Follicular Variant of Papillary Thyroid Carcinoma.

PubMed

Hahn, Soo Yeon; Shin, Jung Hee; Oh, Young Lyun; Kim, Tae Hyuk; Lim, Yaeji; Choi, Ji Soo

2017-09-01

Follicular variant of papillary thyroid carcinoma (FVPTC) is traditionally divided into infiltrative and encapsulated types. Adding to this classification, noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) represents a reclassification of a subset of cases (encapsulated tumors without lymphovascular or capsular invasion). The purpose of this study was to assess the role of ultrasound (US) in predicting tumor invasiveness in FVPTC. From January 2014 to May 2016, preoperative US examinations were performed on 151 patients with 152 FVPTCs who underwent surgery. Based on a pathologic analysis, the FVPTCs were categorized into three groups: NIFTP, invasive encapsulated FVPTC (iE-FVPTC), or infiltrative FVPTC (I-FVPTC). Each nodule was categorized based on the US pattern according to the Korean Thyroid Imaging Reporting and Data System (K-TIRADS) and the American Thyroid Association (ATA) guidelines. The correlation between tumor invasiveness and the K-TIRADS or ATA category was investigated using Spearman's rank correlation coefficient. Among the 152 FVPTCs, there were 48 (31.6%) NIFTPs, 60 (39.5%) iE-FVPTCs, and 44 (28.9%) I-FVPTCs. US characteristics of the FVPTCs differed significantly according to tumor invasiveness (p ≤ 0.030). Tumor invasiveness showed a significant positive correlation with K-TIRADS (tumors of all sizes: r = 0.591, p < 0.001; tumors ≥1.0 cm: r = 0.427, p < 0.001) and ATA categories (tumors of all sizes: r = 0.532, p < 0.001; tumors ≥1.0 cm: r = 0.466, p < 0.001). According to both K-TIRADS and ATA guidelines for all-sized tumors, the most common subtype was NIFTP in low-suspicion nodules (52.6% and 51.6%), iE-FVPTC in intermediate-suspicion nodules (52.7% and 54.2%), and I-FVPTC in high-suspicion nodules (82.5% and 69.4%). After surgery, lymph node metastases were confirmed in two (4.2%) NIFTP cases, three (5.0%) iE-FVPTC cases, and eight (18.2%) I-FVPTC cases (p = 0.001). The results of the BRAF mutation analysis were not significantly different between the groups (p = 0.507). Increasing tumor invasiveness from NIFTP to iE-FVPTC to I-FVPTC is positively correlated with the level of suspicion on US using both K-TIRADS and ATA guidelines.

The Mechanism of Action of Unique Small Molecules that Inhibit the Pim Protein Kinase Blocking Prostate Cancer Cell Growth

DTIC Science & Technology

2010-05-01

shown. (E) Cap-dependent ( gray bars) and IRES-dependent (black bars) translation in MEFs as measured by Renilla and Firefly luciferase activities...AGC ATC AAC C; EPHA2-R, GTG ACC TCG TAC TTC CAC ACT C. HER3-F, CGA TGC TGA GAA CCA ATA CCA G; HER3-R, ATA GCC TGT CAC TTC TCG AAT C. INSR-F, GGA AGT...TAC GTC TGA TTC GAG G; INSR-R, TGA GTG ATG GTG AGG TTG TG. IGF1R-F, CCT GCA CAA CTC CAT CTT CGT G; IGF1R-R, CGG TGA TGT TGT AGG TGT CTG C. EGFR-F

Molecular Mechanisms of Soft Tissue Regeneration and Bone Formation in Mice: Implication in Fracture Repair and Wound Healing in Humans

DTIC Science & Technology

2008-04-01

designed in this study: Mg4718-F: 5’-GCA TTT TGA TCC CTT ATA ATA CA-3’ Mg4718-R: 5’- GTG GAA GAC CCT TGA ATG G-3’ Mg4723-F: 5’-GCA TAG CCA ACA AAA...GAA ATC TAA TG-3’ Mg4723-R: 5’-GCA GTG TAG CTC AGT GGT AGA TCA C-3’ After each cross, the progenies were genotyped as described above. We have also...mutant F2 mice. PPD is a likelihood statistic that gives rise to the 95% confidence intervals, which is indicated by gray horizontal bars. cM

Hypoxic ventilatory sensitivity in men is not reduced by prolonged hyperoxia (Predictive Studies V and VI)

NASA Technical Reports Server (NTRS)

Gelfand, R.; Lambertsen, C. J.; Clark, J. M.; Hopkin, E.

1998-01-01

Potential adverse effects on the O2-sensing function of the carotid body when its cells are exposed to toxic O2 pressures were assessed during investigations of human organ tolerance to prolonged continuous and intermittent hyperoxia (Predictive Studies V and VI). Isocapnic hypoxic ventilatory responses (HVR) were determined at 1.0 ATA before and after severe hyperoxic exposures: 1) continuous O2 breathing at 1.5, 2.0, and 2.5 ATA for 17.7, 9.0, and 5.7 h and 2) intermittent O2 breathing at 2.0 ATA (30 min O2-30 min normoxia) for 14.3 O2 h within 30-h total time. Postexposure curvature of HVR hyperbolas was not reduced compared with preexposure controls. The hyperbolas were temporarily elevated to higher ventilations than controls due to increments in respiratory frequency that were proportional to O2 exposure time, not O2 pressure. In humans, prolonged hyperoxia does not attenuate the hypoxia-sensing function of the peripheral chemoreceptors, even after exposures that approach limits of human pulmonary and central nervous system O2 tolerance. Current applications of hyperoxia in hyperbaric O2 therapy and in subsea- and aerospace-related operations are guided by and are well within these exposure limits.

Effect of recombinant human follicle-stimulating hormone and luteinizing hormone on in vitro maturation of porcine oocytes evaluated by the subsequent in vitro development of embryos obtained by in vitro fertilization, intracytoplasmic sperm injection, or parthenogenetic activation.

PubMed

Silvestre, M A; Alfonso, J; García-Mengual, E; Salvador, I; Duque, C C; Molina, I

2007-05-01

The aim of this work was to study the effect of recombinant human (rh) FSH and LH on in vitro maturation of pig oocytes compared with a conventional hormonal supplement based on equine (PMSG) and human chorionic gonadotropins (hCG), as evaluated by the developmental ability of 3 types of pig embryos obtained by in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), or artificial activation (ATA). In Exp. 1, one cumulus-oocyte complex group (A group) was supplemented with rh-FSH and rh-LH (0.1 IU/mL each), and the other group (B group) was supplemented with PMSG and hCG (10 IU/mL each). No differences in nuclear maturation between the A and B groups were observed (68.5 vs. 71.4%, respectively). No differences were detected between hormonal treatments in the rates of cleavage or blastocyst formation of ATA, IVF, and ICSI embryos. Total cell number of the embryos was not significantly different in any experimental group (A: 31.1, 28.5, and 19.8 vs. B: 25.2, 25.5, and 20.6 for ATA, IVF, and ICSI embryos, respectively). In Exp. 2, the effects of different concentrations of rh-FSH and rh-LH (0.5, 0.1, or 0.05 IU/mL) in maturation medium on nuclear maturation and in vitro development of embryos obtained by IVF were studied. No effect of different hormonal concentrations on blastocyst formation rates was observed (8.5, 13.0, and 5.7%, respectively). Blastocyst cell number was not different in any experimental group. In conclusion, the results obtained here permit us to substitute PMSG and hCG with rh-FSH and rh-LH and to produce pig embryos obtained by IVF, ICSI, or ATA.

Early Generated B-1-Derived B Cells Have the Capacity To Progress To Become Mantle Cell Lymphoma-like Neoplasia in Aged Mice.

PubMed

Hayakawa, Kyoko; Formica, Anthony M; Nakao, Yuka; Ichikawa, Daiju; Shinton, Susan A; Brill-Dashoff, Joni; Smith, Mitchell R; Morse, Herbert C; Hardy, Richard R

2018-06-13

In mice, fetal/neonatal B-1 cell development generates murine CD5 + B cells (B1a) with autoreactivity. We analyzed B1a cells at the neonatal stage in a V H 11/D/J H knock-in mouse line (V H 11t) that generates an autoreactive antiphosphatidylcholine BCR. Our study revealed that antiphosphatidylcholine B1a cells develop in liver, mature in spleen, and distribute in intestine/colon, mesenteric lymph node (mLN), and body cavity as the outcome of B-1 cell development before B-2 cell development. Throughout life, self-renewing B-1 B1a cells circulate through intestine, mesenteric vessel, and blood. The body cavity-deposited B1a cells also remigrate. In old age, some B1a cells proceed to monoclonal B cell lymphocytosis. When neonatal B-1 B1a cells express an antithymocyte/Thy-1 autoreactivity (ATA) BCR transgene in the C.B17 mouse background, ATA B cells increase in PBL and strongly develop lymphomas in aging mice that feature splenomegaly and mLN hyperplasia with heightened expression of CD11b, IL-10, and activated Stat3. At the adult stage, ATA B cells were normally present in the mantle zone area, including in intestine. Furthermore, frequent association with mLN hyperplasia suggests the influence by intestinal microenvironment on lymphoma development. When cyclin D1 was overexpressed by the Eμ-cyclin D1 transgene, ATA B cells progressed to further diffused lymphoma in aged mice, including in various lymph nodes with accumulation of IgM hi IgD lo CD5 + CD23 - CD43 + cells, resembling aggressive human mantle cell lymphoma. Thus, our findings reveal that early generated B cells, as an outcome of B-1 cell development, can progress to become lymphocytosis, lymphoma, and mantle cell lymphoma-like neoplasia in aged mice. Copyright © 2018 by The American Association of Immunologists, Inc.

Selective deposition of dietary α-Lipoic acid in mitochondrial fraction and its synergistic effect with α-Tocoperhol acetate on broiler meat oxidative stability

PubMed Central

2013-01-01

The use of bioactive antioxidants in feed of broiler to mitigate reactive oxygen species (ROS) in biological systems is one of promising nutritional strategies. The aim of present study was to alleviate ROS production in mitochondrial fraction (MF) of meat by supplemented dietary antioxidant in feed of broiler. For this purpose, mitochondria specific antioxidant: α-lipoic acid (25 mg, 75 mg and 150 mg) with or without combination of α-tocopherol acetate (200 mg) used in normal and palm olein oxidized oil (4%) supplemented feed. One hundred and eighty one day old broiler birds were randomly divided into six treatments and provided the mentioned feed from third week. Feed intake, feed conversion ratio (FCR) remained statistically same in all groups while body weight decreased in supplemented groups accordingly at the end of study. The broiler meat MF antioxidant potential was significantly improved by feeding supplemented feed estimated as 1,1-di phenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity, 2,2-azinobis-(3- ethylbenzothiazoline-6-sulphonic acid) (ABTS+) and thiobarbituric acid reactive substances (TBARS). The maximum antioxidant activity was depicted in group fed on 150 mg/kg α-lipoic acid (ALA) and 200 mg/kg α-tocopherol acetate (ATA) (T4) in both breast and leg MF. Moreover, TBARS were higher in leg as compared to breast MF. Although, oxidized oil containing feed reduced the growth, lipid stability and antioxidant potential of MF whilst these traits were improved by receiving feed containing ALA and ATA. ALA and ATA showed higher deposition in T4 group while least in group received oxidized oil containing feed (T5). Positive correlation exists between DPPH free radical scavenging activity and the ABTS + reducing activity. In conclusion, ALA and ATA supplementation in feed had positive effect on antioxidant status of MF that consequently diminished the oxidative stress in polyunsaturated fatty acid enriched meat. PMID:23617815

The Influence of Intrinsic and Extrinsic Factors on Neurogenesis

DTIC Science & Technology

2008-07-31

ACG AAT TGA GCA ATA ACG GTG ATG GCG ATA GTA AGA ACA GTT C 49 Table II-2. Sequence information and physical characteristics of...CTC TGA GCT AGT 550 50 24 60.15 3’mAT-O GTG ACA CTA GCA GAC CAG ATT CCT 550 50 24 61.08 5’mAT-N GCC TCT GAG CTA GTA TGT GTC ATC 274 50 24 59.46 3...8217mAT-N CCA TCA CCT TCT CCT TTC TAG GTC 274 50 24 61.64 5’rAT-O TTT AGC TCA GTG GTA GAG CGC 257 52 21 56 3’rAT-O GTT TCT GCC CTT TCC AAC TGC 257 52 21

Hemostatic abnormalities in dogs with naturally occurring heatstroke.

PubMed

Bruchim, Yaron; Kelmer, Efrat; Cohen, Adar; Codner, Carolina; Segev, Gilad; Aroch, Itamar

2017-05-01

To investigate hemostatic analyte abnormalities and their association with mortality in dogs with naturally occurring heatstroke. Prospective observational study. University teaching hospital. Thirty client-owned dogs with naturally occurring heatstroke. None. Citrated and EDTA blood samples were collected at presentation and at 4, 12, 24, 36, and 48 hours postpresentation (PP). Hemostatic tests performed included platelet count, prothrombin and activated partial thromboplastin times (PT and aPTT, respectively), antithrombin activity (ATA), total protein C activity (tPCA), fibrinogen, and D-dimer concentrations. The overall survival rate was 60% (18/30 dogs). Older age, higher heart rate and rectal temperature at presentation, and time from onset of clinical signs to presentation were significantly associated with mortality. Hemostatic analytes at presentation were not associated with mortality. Prolonged PT and aPTT at 12-24 hours PP, lower tPCA at 12 hours PP, and hypofibrinogenemia at 24 hours PP were significantly (P < 0.05) associated with mortality. Increased D-dimer concentration and low ATA were common at all time points, but were not associated with mortality. The frequency of disseminated intravascular coagulation (DIC) increased in nonsurvivors throughout hospitalization, but the development of DIC was not associated with mortality. The number of abnormal coagulation disturbances during the first 24 hours was significantly higher in nonsurvivors (P = 0.04). Hemostatic derangements are common in dogs with naturally occurring heatstroke. Alterations in PT, aPTT, tPCA, and fibrinogen concentrations appear to be associated with the outcome at 12-24 hours PP, exemplifying the need for serial measurement of multiple laboratory hemostatic tests during hospitalization, even when within reference interval on presentation. The development of DIC, as defined in this cohort, was not associated with mortality; however, nonsurvivors had significantly more coagulation abnormalities during the first 24 hours PP. © Veterinary Emergency and Critical Care Society 2017.

Effect of aspirin desensitization on T-cell cytokines and plasma lipoxins in aspirin-exacerbated respiratory disease.

PubMed

Aksu, Kurtuluş; Kurt, Emel; Alatas, Özkan; Gülbas, Zafer

2014-01-01

The pathogenesis of aspirin-exacerbated respiratory disease (AERD) is thought to be based on, mainly, overproduction of eicosanoid lipid mediators and on defective anti-inflammatory regulators. Aspirin desensitization treatment, the mainstay of controlling asthma and rhinitis in AERD patients, however, is the least understood aspect of the disease. The study was designed to determine the effect of aspirin desensitization on T-lymphocyte cytokine expression and on plasma lipoxin levels in AERD. Spirometry, skin-prick test and asthma control test were documented and intracellular cytokine expression in T lymphocytes and plasma lipoxin levels were measured in 23 AERD patients, 17 aspirin-tolerant asthmatic (ATA) patients, and 16 healthy controls. In the AERD group nasal symptom and smell scores were assessed. Of the 23 AERD patients 15 accepted to undergo aspirin desensitization protocol and 14 of them were desensitized successfully. In the desensitized AERD group, cytokine and lipoxin measurements were repeated after 1-month aspirin treatment. CD4(+) IL-10 levels were higher in AERD patients than in healthy controls and CD4(+) interferon (IFN) gamma levels were higher in AERD and ATA patients than in controls. Plasma lipoxin-A4 and 15-epi-lipoxin-A4 levels were similar among the three study groups. In the AERD group, subjects underwent aspirin desensitization followed by a 1-month aspirin treatment. Clinical parameters improved and CD4(+) IFN-gamma levels decreased significantly. No significant change in lipoxin levels was recorded. CD4(+) IFN-gamma and CD4(+) IL-10 levels in AERD patients after 1-month aspirin desensitization treatment were similar to the healthy controls. The study confirms aspirin desensitization is effective clinically in AERD patients and suggests that IFN gamma and IL-10 expression in CD4(+) T lymphocytes may be related to the mechanism of action.

A 2013 survey of clinical practice patterns in the management of primary hypothyroidism.

PubMed

Burch, Henry B; Burman, Kenneth D; Cooper, David S; Hennessey, James V

2014-06-01

In 2012, comprehensive clinical practice guidelines (CPGs) were published regarding the management of hypothyroidism. We sought to document current practices in the management of primary hypothyroidism and compare these results with recommendations made in the 2012 American Thyroid Association (ATA)/American Association of Clinical Endocrinologists (AACE) hypothyroidism CPGs. In addition, we sought to examine differences in management among international members of U.S.-based endocrine societies and to compare survey results with those obtained from a survey of ATA members performed 12 years earlier. Clinical members of The Endocrine Society (TES), the ATA, and the AACE were asked to take a web-based survey consisting of 30 questions dealing with testing, treatment, and modulating factors in the management of primary hypothyroidism. In total, 880 respondents completed the survey, including 618 members of TES, 582 AACE members, and 208 ATA members. North American respondents accounted for 67.6%, Latin American 9.7%, European 9.2%, Asia and Oceania 8.1%, and Africa and Middle East 5.5%. Overt hypothyroidism would be treated using l-T4 alone by 99.2% of respondents; 0.8% would use combination l-T4 and liothyronine (l-T3) therapy. Generic l-T4 would be used by 49.3% and a brand name by 49.9%. The rate of replacement would be gradual (38.5%); an empiric dose, adjusted to achieve target (33.6%); or a calculated full replacement dose (27.8%). A target TSH of 1.0 to 1.9 mU/L was favored in the index case, but 3.0 to 3.9 mU/L was the most commonly selected TSH target for an octogenarian. Persistent hypothyroid symptoms despite achieving a target TSH would prompt testing for other causes by 84.3% of respondents, a referral to primary care by 11.3%, and a change to l-T4 plus l-T3 therapy by 3.6%. Evaluation of persistent symptoms would include measurement of T3 levels by 21.9% of respondents. Subclinical disease with a TSH 5.0 to 10.0 mU/L would be treated without further justification by 21.3% of respondents, or in the presence of positive thyroid peroxidase antibodies (62.3%), hypothyroid symptoms (60.9%), high low-density lipoprotein (52.9%), or goiter (46.6%). The TSH target for a newly pregnant patient was <2.5 mU/L for 96.1% of respondents, with 63.5% preferring a TSH target <1.5 mU/L. Thyroid hormone levels would be checked every 4 weeks during pregnancy by 67.7% and every 8 weeks by an additional 21.4%. A hypothyroid patient with TSH of 0.5 mU/L who becomes pregnant would receive an immediate l-T4 dose increase by only 36.9% of respondents. The current survey of clinical endocrinologists catalogs current practice patterns in the management of hypothyroidism and demonstrates 1) a nearly exclusive preference for l-T4 alone as initial therapy, 2) the widespread use of age-specific TSH targets for replacement therapy, 3) a low threshold for treating mild thyroid failure, 4) meticulous attention to TSH targets in the pregnant and prepregnant woman, and 5) a highly variable approach to both the rate and means of restoring euthyroidism for overt disease. Both alignment and focal divergence from recent CPGs are demonstrated.

The IL1B-511 Polymorphism (rs16944 AA Genotype) Is Increased in Aspirin-Exacerbated Respiratory Disease in Mexican Population.

PubMed

Falfán-Valencia, Ramcés; Pavón-Romero, Gandhi F; Camarena, Angel; García, María de la Luz; Galicia-Negrete, Gustavo; Negrete-García, María Cristina; Teran, Luis Manuel

2012-01-01

Aspirin exacerbated respiratory disease (AERD) is characterized by chronic hyperplastic rhinosinusitis, nasal polyposis, asthma, and aspirin sensitivity. The mechanisms which produce these manifestations of intolerance are not fully defined, current research focuses on cyclooxygenase 1 (COX-1) inhibition, metabolism of arachidonic acid, and the COX pathway to the lipoxygenase (LO) route, inducing increased synthesis of leukotrienes (LT). The biological plausibility of this model has led to the search for polymorphisms in genes responsible for proinflammatory cytokines synthesis, such as IL1B and IL8. We performed a genetic association study between IL8-251 (rs4073) and IL1B-511 (rs16944) polymorphisms in AERD, aspirin-tolerant asthma (ATA), and healthy control subjects. Using allelic discrimination by real-time PCR, we found statistically nonsignificant associations between AERD, ATA, and healthy control subjects for the GG and GA genotypes of IL1B (rs16944). Interestingly, the AA genotype showed an increased frequency in the AERD patients versus the ATA group (GF = 0.19 versus 0.07, p = 0.018, OR 2.98, and 95% CI 1.17-7.82). This is the first observation that IL1B polymorphisms are involved in AERD. Thus, future studies must investigate whether interleukin-1β is released in the airways of AERD patients and whether it relates to genetic polymorphisms in the IL1B gene.

Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice.

PubMed

Camporez, João-Paulo G; Petersen, Max C; Abudukadier, Abulizi; Moreira, Gabriela V; Jurczak, Michael J; Friedman, Glenn; Haqq, Christopher M; Petersen, Kitt Falk; Shulman, Gerald I

2016-02-23

Sarcopenia, or skeletal muscle atrophy, is a debilitating comorbidity of many physiological and pathophysiological processes, including normal aging. There are no approved therapies for sarcopenia, but the antihypertrophic myokine myostatin is a potential therapeutic target. Here, we show that treatment of young and old mice with an anti-myostatin antibody (ATA 842) for 4 wk increased muscle mass and muscle strength in both groups. Furthermore, ATA 842 treatment also increased insulin-stimulated whole body glucose metabolism in old mice, which could be attributed to increased insulin-stimulated skeletal muscle glucose uptake as measured by a hyperinsulinemic-euglycemic clamp. Taken together, these studies provide support for pharmacological inhibition of myostatin as a potential therapeutic approach for age-related sarcopenia and metabolic disease.

Pathogenetic Influences of Human Herpesvirus 8 (HHV-8) in Prostate Cancer Progression

DTIC Science & Technology

2012-05-25

expression of each GOI were calculated by raising 2 to the negative value ΔΔCt for each sample. Primer sequences used were: AR-F: 5’ ATG GTG AGC AGA... GTG CCC TAT C 3’ AR- R: 5’ ATG GTC CCT GGC AGT CTC CAA A 3’ PSA-F: CGC AAG TTC ACC CTC AGA AGG T 3’ PSA-R: 5’ GAC GTG ATA CCT TGA AGC ACA CC 3’ MSMB-F...TGG CGT TCC AGG GAC TCA T 3’ Zeb1-F: 5’ GGC ATA CAC CTA CTC AAC TAC GG 3’ Zeb1-R: 5’ TGG GCG GTG TAG AAT CAG AGT C 3’ Snail-F: 5’ TGC CCT CAA GAT

Effects of hyperbaric oxygen on Pseudomonas aeruginosa susceptibility to imipenem and macrophages.

PubMed

Lima, Flavia Luna; Joazeiro, Paulo Pinto; Lancellotti, Marcelo; de Hollanda, Luciana Maria; de Araújo Lima, Bruna; Linares, Edlaine; Augusto, Ohara; Brocchi, Marcelo; Giorgio, Selma

2015-01-01

The seriousness to treat burn wounds infected with Pseudomonas aeruginosa led us to examine whether the effect of the carbapenem antibiotic imipenem is enhanced by hyperbaric oxygen (HBO). The effects of HBO (100% O2, 3 ATA, 5 h) in combination with imipenen on bacterial counts of six isolates of P. aeruginosa and bacterial ultrastructure were investigated. Infected macrophages were exposed to HBO (100% O2, 3 ATA, 90 min) and the production of reactive oxygen species monitored. HBO enhanced the effects of imipenen. HBO increased superoxide anion production by macrophages and likely kills bacteria by oxidative mechanisms. HBO in combination with imipenem can be used to kill P. aeruginosa in vitro and such treatment may be beneficial for the patients with injuries containing the P. aeruginosa.

Optimal Assembly of Psychological and Educational Tests.

ERIC Educational Resources Information Center

van der Linden, Wim J.

1998-01-01

Reviews optimal test-assembly literature and introduces the contributions to this special issue. Discusses four approaches to computerized test assembly: (1) heuristic-based test assembly; (2) 0-1 linear programming; (3) network-flow programming; and (4) an optimal design approach. Contains a bibliography of 90 sources on test assembly.…

49 CFR 572.162 - Head assembly and test procedure.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 7 2012-10-01 2012-10-01 false Head assembly and test procedure. 572.162 Section... Hybrid III Six-Year-Old Weighted Child Test Dummy § 572.162 Head assembly and test procedure. The head assembly is assembled and tested as specified in 49 CFR 572.122 (Subpart N). ...

49 CFR 572.162 - Head assembly and test procedure.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 7 2010-10-01 2010-10-01 false Head assembly and test procedure. 572.162 Section... Hybrid III Six-Year-Old Weighted Child Test Dummy § 572.162 Head assembly and test procedure. The head assembly is assembled and tested as specified in 49 CFR 572.122 (Subpart N). ...

49 CFR 572.162 - Head assembly and test procedure.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 7 2014-10-01 2014-10-01 false Head assembly and test procedure. 572.162 Section... Hybrid III Six-Year-Old Weighted Child Test Dummy § 572.162 Head assembly and test procedure. The head assembly is assembled and tested as specified in 49 CFR 572.122 (Subpart N). ...

49 CFR 572.163 - Neck assembly and test procedure.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 7 2014-10-01 2014-10-01 false Neck assembly and test procedure. 572.163 Section... Hybrid III Six-Year-Old Weighted Child Test Dummy § 572.163 Neck assembly and test procedure. The neck assembly is assembled and tested as specified in 49 CFR 572.123 (Subpart N). ...

49 CFR 572.163 - Neck assembly and test procedure.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 7 2013-10-01 2013-10-01 false Neck assembly and test procedure. 572.163 Section... Hybrid III Six-Year-Old Weighted Child Test Dummy § 572.163 Neck assembly and test procedure. The neck assembly is assembled and tested as specified in 49 CFR 572.123 (Subpart N). ...

49 CFR 572.162 - Head assembly and test procedure.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 7 2011-10-01 2011-10-01 false Head assembly and test procedure. 572.162 Section... Hybrid III Six-Year-Old Weighted Child Test Dummy § 572.162 Head assembly and test procedure. The head assembly is assembled and tested as specified in 49 CFR 572.122 (Subpart N). ...

49 CFR 572.163 - Neck assembly and test procedure.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 7 2012-10-01 2012-10-01 false Neck assembly and test procedure. 572.163 Section... Hybrid III Six-Year-Old Weighted Child Test Dummy § 572.163 Neck assembly and test procedure. The neck assembly is assembled and tested as specified in 49 CFR 572.123 (Subpart N). ...

49 CFR 572.162 - Head assembly and test procedure.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 7 2013-10-01 2013-10-01 false Head assembly and test procedure. 572.162 Section... Hybrid III Six-Year-Old Weighted Child Test Dummy § 572.162 Head assembly and test procedure. The head assembly is assembled and tested as specified in 49 CFR 572.122 (Subpart N). ...

49 CFR 572.163 - Neck assembly and test procedure.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 7 2010-10-01 2010-10-01 false Neck assembly and test procedure. 572.163 Section... Hybrid III Six-Year-Old Weighted Child Test Dummy § 572.163 Neck assembly and test procedure. The neck assembly is assembled and tested as specified in 49 CFR 572.123 (Subpart N). ...

49 CFR 572.163 - Neck assembly and test procedure.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 7 2011-10-01 2011-10-01 false Neck assembly and test procedure. 572.163 Section... Hybrid III Six-Year-Old Weighted Child Test Dummy § 572.163 Neck assembly and test procedure. The neck assembly is assembled and tested as specified in 49 CFR 572.123 (Subpart N). ...

Antithyroid Antibodies Are Implicated in Epileptogenesis of Adult Patients With Epilepsy.

PubMed

Tsai, Meng-Han; Fu, Ting-Ying; Chen, Nai-Ching; Shih, Fu-Yuan; Lu, Yan-Ting; Cheng, Mei-Yun; Chuang, Hung-Yi; Chuang, Yao-Chung

2015-07-01

Antithyroid antibodies (Abs) are associated with epilepsy in steroid-responsive encephalopathy, but have been rarely studied in unselected epilepsy patients. This study aimed to characterize the prevalence and associated factors of antithyroid Abs and other auto-Abs in adult patients with epilepsy.Epilepsy patients without autoimmune disorders were surveyed for antinuclear antibody (ANA), anti-β2 glycoprotein 1 antibody (aβ2GP1), anticardiolipin IgG Ab, antimicrosomal antibody (AMA), antithyroglobulin antibody (ATA), and thyroid function test.Of 319 patients, 75 (23.5%) were positive for at least 1 Ab. The most common Ab was anticardiolipin antibody (aCL) (30/319, 9.4%), followed by AMA (24/319, 7.5%), ANA (18/319, 5.6%), aβ2GP1 (18/319, 6.5%), and ATA (6/319, 3.25%). Antimicrosomal Abs were significantly more frequent in patients who were female, older at disease onset, older at the time of study, and had unknown seizure etiology. The presence of aCL was significantly associated with more frequent seizures. Most patients with antithyroid Ab were female and had focal seizures with unknown etiology.The association of different auto-Abs with different factors suggests that they may have different roles in adult patients with epilepsy. Recurrent seizures and certain antiepileptic medications may cause the production of aCL. The role of antithyroid Abs in adult focal epilepsy with unknown cause, especially in females, warrants further evaluation because of the potential implications on treatment.

Antithyroid Antibodies Are Implicated in Epileptogenesis of Adult Patients With Epilepsy

PubMed Central

Tsai, Meng-Han; Fu, Ting-Ying; Chen, Nai-Ching; Shih, Fu-Yuan; Lu, Yan-Ting; Cheng, Mei-Yun; Chuang, Hung-Yi; Chuang, Yao-Chung

2015-01-01

Abstract Antithyroid antibodies (Abs) are associated with epilepsy in steroid-responsive encephalopathy, but have been rarely studied in unselected epilepsy patients. This study aimed to characterize the prevalence and associated factors of antithyroid Abs and other auto-Abs in adult patients with epilepsy. Epilepsy patients without autoimmune disorders were surveyed for antinuclear antibody (ANA), anti-β2 glycoprotein 1 antibody (aβ2GP1), anticardiolipin IgG Ab, antimicrosomal antibody (AMA), antithyroglobulin antibody (ATA), and thyroid function test. Of 319 patients, 75 (23.5%) were positive for at least 1 Ab. The most common Ab was anticardiolipin antibody (aCL) (30/319, 9.4%), followed by AMA (24/319, 7.5%), ANA (18/319, 5.6%), aβ2GP1 (18/319, 6.5%), and ATA (6/319, 3.25%). Antimicrosomal Abs were significantly more frequent in patients who were female, older at disease onset, older at the time of study, and had unknown seizure etiology. The presence of aCL was significantly associated with more frequent seizures. Most patients with antithyroid Ab were female and had focal seizures with unknown etiology. The association of different auto-Abs with different factors suggests that they may have different roles in adult patients with epilepsy. Recurrent seizures and certain antiepileptic medications may cause the production of aCL. The role of antithyroid Abs in adult focal epilepsy with unknown cause, especially in females, warrants further evaluation because of the potential implications on treatment. PMID:26131823

Assembly, alignment and test of the Transiting Exoplanet Survey Satellite (TESS) optical assemblies

NASA Astrophysics Data System (ADS)

Balonek, Gregory; Brown, Joshua J.; Andre, James E.; Chesbrough, Christian D.; Chrisp, Michael P.; Dalpiaz, Michael; Lennon, Joseph; Richards, B. C.; Clark, Kristin E.

2017-08-01

The Transiting Exoplanet Survey Satellite (TESS) will carry four visible waveband, seven-element, refractive F/1.4 lenses, each with a 34 degree diagonal field of view. This paper describes the methods used for the assembly, alignment and test of the four flight optical assemblies. Prior to commencing the build of the four flight optical assemblies, a Risk Reduction Unit (RRU) was successfully assembled and tested [1]. The lessons learned from the RRU were applied to the build of the flight assemblies. The main modifications to the flight assemblies include the inking of the third lens element stray light mitigation, tighter alignment tolerances, and diamond turning for critical mechanical surfaces. Each of the optical assemblies was tested interferometrically and measured with a low coherence distance measuring interferometer (DMI) to predict the optimal shim thickness between the lens assembly and detector before -75°C environmental testing. In addition to individual test data, environmental test results from prior assemblies allow for the exploration of marginal performance differences between each of the optical assemblies.

Effects of high-pressure oxygen therapy on brain tissue water content and AQP4 expression in rabbits with cerebral hemorrhage.

PubMed

Wu, Jing; Chen, Jiong; Guo, Hua; Peng, Fang

2014-12-01

To investigate the effects of different atmosphere absolutes (ATA) of high-pressure oxygen (HPO) on brain tissue water content and Aquaporin-4 (AQP4) expression in rabbits with cerebral hemorrhage. 180 New Zealand white rabbits were selected and randomly divided into normal group (n = 30), control group (n = 30) and cerebral hemorrhage group (n = 120), and cerebral hemorrhage group was divided into group A, B, C and D with 30 rabbits in each group. The groups received 1.0, 1.8, 2.0 and 2.2 ATA of HPO treatments, respectively. Ten rabbits in each group were killed at first, third and fifth day to detect the brain tissue water content and change of AQP4 expression. In cerebral hemorrhage group, brain tissue water content and AQP4 expression after model establishment were first increased, then decreased and reached the maximum on third day (p < 0.05). Brain tissue water content and AQP4 expression in control group and cerebral hemorrhage group were significantly higher than normal group at different time points (p < 0.05). In contrast, brain tissue water content and AQP4 expression in group C were significantly lower than in group A, group B, group D and control group (p < 0.05). In control group, AQP4-positive cells significantly increased after model establishment, which reached maximum on third day, and positive cells in group C were significantly less than in group A, group B and group D. We also found that AQP4 expression were positively correlated with brain tissue water content (r = 0.719, p < 0.05) demonstrated by significantly increased AQP4 expression along with increased brain tissue water content. In conclusion, HPO can decrease AQP4 expression in brain tissue of rabbits with cerebral hemorrhage to suppress the progression of brain edema and promote repairing of injured tissue. 2.0 ATA HPO exerts best effects, which provides an experimental basis for ATA selection of HPO in treating cerebral hemorrhage.

The January 2015 Repressurization of ISS ATCS Loop B - Analysis Limitations and Concerns

NASA Technical Reports Server (NTRS)

Ungar, Eugene; Rankin, J. Gary; Schaff, Mary; Figueroa, Marcelino

2015-01-01

In January 2013 a false ammonia leak alarm resulted in the shutdown and partial depressurization of one of the two International Space Station (ISS) External Active Thermal Control System (EATCS) loops. The depressurization resulted in a vapor bubble of 18 liters in warm parts of the stagnant loop. To repressurize the loop and regain system operation, liquid would have to be moved from the Ammonia Tank Assembly (ATA) into the loop. This resulted in the possibility of moving cold (as low as -30 C) ammonia into the water-filled Internal Active Thermal Control System (IATCS) interface heat exchangers. Before moving forward, the freezing potential of the repressurization was evaluated through analysis - using both a Thermal Desktop SINDA/FLUINT model and hand calculations. The models yielded very different results, but both models indicated that heat exchanger freezing was not an issue. Therefore, the repressurization proceeded. The presentation describes the physical situation of the EATCS prior to repressurization and discusses the potential limits and pitfalls of the repressurization. The pre-repressurization analytical models and their results are discussed. The successful repressurization is describled and the results of a post-event model assessment is detailed.

78 FR 78705 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-27

..., and equipment to perform this type of modification, repair, and access. UAL also stated that certain... Association (ATA) of America Code 25, Equipment/ Furnishings; and Code 53, Fuselage. (e) Reason This AD was...

American Telemedicine Association

MedlinePlus

... To ATA Home {{desc}} ', captionModule: 'caption' }); $(document).on( 'cycle-update-view', function( e, opts, slideOpts, currSlide ) { if ( ... currSlide ) ); el.show(); } else { el.hide(); } }); }); $(document).on( 'cycle-destroyed', function( e, opts ) { var el; $.each(['caption',' ...

Electrically switchable photonic liquid crystal devices for routing of a polarized light wave

NASA Astrophysics Data System (ADS)

Rushnova, Irina I.; Melnikova, Elena A.; Tolstik, Alexei L.; Muravsky, Alexander A.

2018-04-01

The new mode of LC alignment based on photoalignment AtA-2 azo dye where the refractive interface between orthogonal orientations of the LC director exists without voltage and disappeared or changed with critical voltage has been proposed. The technology to fabricate electrically controlled liquid crystal elements for spatial separation and switching of linearly polarized light beams on the basis of the total internal reflection effect has been significantly improved. Its distinctive feature is the application of a composite alignment material comprising two sublayers of Nylon-6 and AtA-2 photoalignment azo dye offering patterned liquid crystal director orientation with high alignment quality value q = 0 . 998. The fabricated electrically controlled spatially structured liquid crystal devices enable implementation of propagation directions separation for orthogonally polarized light beams and their switching with minimal crosstalk.

Hydrogen gas alleviates oxygen toxicity by reducing hydroxyl radical levels in PC12 cells.

PubMed

Yu, Junchao; Yu, Qiuhong; Liu, Yaling; Zhang, Ruiyun; Xue, Lianbi

2017-01-01

Hyperbaric oxygen (HBO) therapy through breathing oxygen at the pressure of above 1 atmosphere absolute (ATA) is useful for varieties of clinical conditions, especially hypoxic-ischemic diseases. Because of generation of reactive oxygen species (ROS), breathing oxygen gas at high pressures can cause oxygen toxicity in the central nervous system, leading to multiple neurological dysfunction, which limits the use of HBO therapy. Studies have shown that Hydrogen gas (H2) can diminish oxidative stress and effectively reduce active ROS associated with diseases. However, the effect of H2 on ROS generated from HBO therapy remains unclear. In this study, we investigated the effect of H2 on ROS during HBO therapy using PC12 cells. PC12 cells cultured in medium were exposed to oxygen gas or mixed oxygen gas and H2 at 1 ATA or 5 ATA. Cells viability and oxidation products and ROS were determined. The data showed that H2 promoted the cell viability and inhibited the damage in the cell and mitochondria membrane, reduced the levels of lipid peroxidation and DNA oxidation, and selectively decreased the levels of •OH but not disturbing the levels of O2•-, H2O2, or NO• in PC12 cells during HBO therapy. These results indicated that H2 effectively reduced •OH, protected cells against oxygen toxicity resulting from HBO therapy, and had no effect on other ROS. Our data supported that H2 could be potentially used as an antioxidant during HBO therapy.

The IL1B-511 Polymorphism (rs16944 AA Genotype) Is Increased in Aspirin-Exacerbated Respiratory Disease in Mexican Population

PubMed Central

Falfán-Valencia, Ramcés; Pavón-Romero, Gandhi F.; Camarena, Angel; García, María de la Luz; Galicia-Negrete, Gustavo; Negrete-García, María Cristina; Teran, Luis Manuel

2012-01-01

Aspirin exacerbated respiratory disease (AERD) is characterized by chronic hyperplastic rhinosinusitis, nasal polyposis, asthma, and aspirin sensitivity. The mechanisms which produce these manifestations of intolerance are not fully defined, current research focuses on cyclooxygenase 1 (COX-1) inhibition, metabolism of arachidonic acid, and the COX pathway to the lipoxygenase (LO) route, inducing increased synthesis of leukotrienes (LT). The biological plausibility of this model has led to the search for polymorphisms in genes responsible for proinflammatory cytokines synthesis, such as IL1B and IL8. We performed a genetic association study between IL8-251 (rs4073) and IL1B-511 (rs16944) polymorphisms in AERD, aspirin-tolerant asthma (ATA), and healthy control subjects. Using allelic discrimination by real-time PCR, we found statistically nonsignificant associations between AERD, ATA, and healthy control subjects for the GG and GA genotypes of IL1B (rs16944). Interestingly, the AA genotype showed an increased frequency in the AERD patients versus the ATA group (GF = 0.19 versus 0.07, p = 0.018, OR 2.98, and 95% CI 1.17–7.82). This is the first observation that IL1B polymorphisms are involved in AERD. Thus, future studies must investigate whether interleukin-1β is released in the airways of AERD patients and whether it relates to genetic polymorphisms in the IL1B gene. PMID:22132000

MILES Pressure/Seismic Response Engineering Development of MILES Test Fixture.

DTIC Science & Technology

1980-08-01

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49 CFR 572.152 - Head assembly and test procedure.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 7 2013-10-01 2013-10-01 false Head assembly and test procedure. 572.152 Section... 12-Month-Old Infant, Alpha Version § 572.152 Head assembly and test procedure. (a) The head assembly (refer to § 572.150(a)(1)(i)) for this test consists of the assembly (drawing 921022-001), triaxial mount...

49 CFR 572.152 - Head assembly and test procedure.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 7 2011-10-01 2011-10-01 false Head assembly and test procedure. 572.152 Section... 12-Month-Old Infant, Alpha Version § 572.152 Head assembly and test procedure. (a) The head assembly (refer to § 572.150(a)(1)(i)) for this test consists of the assembly (drawing 921022-001), triaxial mount...

49 CFR 572.152 - Head assembly and test procedure.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 7 2014-10-01 2014-10-01 false Head assembly and test procedure. 572.152 Section... 12-Month-Old Infant, Alpha Version § 572.152 Head assembly and test procedure. (a) The head assembly (refer to § 572.150(a)(1)(i)) for this test consists of the assembly (drawing 921022-001), triaxial mount...

49 CFR 572.152 - Head assembly and test procedure.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 7 2012-10-01 2012-10-01 false Head assembly and test procedure. 572.152 Section... 12-Month-Old Infant, Alpha Version § 572.152 Head assembly and test procedure. (a) The head assembly (refer to § 572.150(a)(1)(i)) for this test consists of the assembly (drawing 921022-001), triaxial mount...

76 FR 81790 - Airworthiness Directives; Hawker Beechcraft Corporation Airplanes Equipped With a Certain...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-29

... modification that included installation of winglets and different engines and propellers) were installed. The... addition of winglets. (d) Subject Joint Aircraft System Component (JASC)/Air Transport Association (ATA) of...

49 CFR 572.122 - Head assembly and test procedure.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 7 2011-10-01 2011-10-01 false Head assembly and test procedure. 572.122 Section...-year-old Child Test Dummy, Beta Version § 572.122 Head assembly and test procedure. (a) The head assembly for this test consists of the complete head (drawing 127-1000), a six-axis neck transducer...

49 CFR 572.122 - Head assembly and test procedure.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 7 2012-10-01 2012-10-01 false Head assembly and test procedure. 572.122 Section...-year-old Child Test Dummy, Beta Version § 572.122 Head assembly and test procedure. (a) The head assembly for this test consists of the complete head (drawing 127-1000), a six-axis neck transducer...

49 CFR 572.122 - Head assembly and test procedure.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 7 2013-10-01 2013-10-01 false Head assembly and test procedure. 572.122 Section...-year-old Child Test Dummy, Beta Version § 572.122 Head assembly and test procedure. (a) The head assembly for this test consists of the complete head (drawing 127-1000), a six-axis neck transducer...

49 CFR 572.122 - Head assembly and test procedure.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 7 2014-10-01 2014-10-01 false Head assembly and test procedure. 572.122 Section...-year-old Child Test Dummy, Beta Version § 572.122 Head assembly and test procedure. (a) The head assembly for this test consists of the complete head (drawing 127-1000), a six-axis neck transducer...

49 CFR 572.172 - Head assembly and test procedure.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 7 2013-10-01 2013-10-01 false Head assembly and test procedure. 572.172 Section... Hybrid III 10-Year-Old Child Test Dummy (HIII-10C) § 572.172 Head assembly and test procedure. (a) The head assembly for this test consists of the complete head (drawing 420-1000), a six-axis neck...

49 CFR 572.142 - Head assembly and test procedure.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 7 2013-10-01 2013-10-01 false Head assembly and test procedure. 572.142 Section...-year-Old Child Crash Test Dummy, Alpha Version § 572.142 Head assembly and test procedure. (a) The head assembly (refer to § 572.140(a)(1)(i)) for this test consists of the head (drawing 210-1000), adapter plate...

49 CFR 572.172 - Head assembly and test procedure.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 7 2014-10-01 2014-10-01 false Head assembly and test procedure. 572.172 Section... Hybrid III 10-Year-Old Child Test Dummy (HIII-10C) § 572.172 Head assembly and test procedure. (a) The head assembly for this test consists of the complete head (drawing 420-1000), a six-axis neck...

49 CFR 572.172 - Head assembly and test procedure.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 7 2012-10-01 2012-10-01 false Head assembly and test procedure. 572.172 Section... Hybrid III 10-Year-Old Child Test Dummy (HIII-10C) § 572.172 Head assembly and test procedure. (a) The head assembly for this test consists of the complete head (drawing 420-1000), a six-axis neck...

49 CFR 572.132 - Head assembly and test procedure.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 7 2014-10-01 2014-10-01 false Head assembly and test procedure. 572.132 Section... Hybrid III 5th Percentile Female Test Dummy, Alpha Version § 572.132 Head assembly and test procedure. (a) The head assembly (refer to § 572.130(a)(1)(i)) for this test consists of the complete head (drawing...

49 CFR 572.142 - Head assembly and test procedure.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 7 2011-10-01 2011-10-01 false Head assembly and test procedure. 572.142 Section...-year-Old Child Crash Test Dummy, Alpha Version § 572.142 Head assembly and test procedure. (a) The head assembly (refer to § 572.140(a)(1)(i)) for this test consists of the head (drawing 210-1000), adapter plate...

49 CFR 572.132 - Head assembly and test procedure.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 7 2012-10-01 2012-10-01 false Head assembly and test procedure. 572.132 Section... Hybrid III 5th Percentile Female Test Dummy, Alpha Version § 572.132 Head assembly and test procedure. (a) The head assembly (refer to § 572.130(a)(1)(i)) for this test consists of the complete head (drawing...

49 CFR 572.142 - Head assembly and test procedure.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 7 2014-10-01 2014-10-01 false Head assembly and test procedure. 572.142 Section...-year-Old Child Crash Test Dummy, Alpha Version § 572.142 Head assembly and test procedure. (a) The head assembly (refer to § 572.140(a)(1)(i)) for this test consists of the head (drawing 210-1000), adapter plate...

49 CFR 572.132 - Head assembly and test procedure.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 7 2011-10-01 2011-10-01 false Head assembly and test procedure. 572.132 Section... Hybrid III 5th Percentile Female Test Dummy, Alpha Version § 572.132 Head assembly and test procedure. (a) The head assembly (refer to § 572.130(a)(1)(i)) for this test consists of the complete head (drawing...

49 CFR 572.132 - Head assembly and test procedure.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 7 2010-10-01 2010-10-01 false Head assembly and test procedure. 572.132 Section... Hybrid III 5th Percentile Female Test Dummy, Alpha Version § 572.132 Head assembly and test procedure. (a) The head assembly (refer to § 572.130(a)(1)(i)) for this test consists of the complete head (drawing...

49 CFR 572.142 - Head assembly and test procedure.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 7 2012-10-01 2012-10-01 false Head assembly and test procedure. 572.142 Section...-year-Old Child Crash Test Dummy, Alpha Version § 572.142 Head assembly and test procedure. (a) The head assembly (refer to § 572.140(a)(1)(i)) for this test consists of the head (drawing 210-1000), adapter plate...

49 CFR 572.132 - Head assembly and test procedure.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 7 2013-10-01 2013-10-01 false Head assembly and test procedure. 572.132 Section... Hybrid III 5th Percentile Female Test Dummy, Alpha Version § 572.132 Head assembly and test procedure. (a) The head assembly (refer to § 572.130(a)(1)(i)) for this test consists of the complete head (drawing...

Selective primary health care: a critical review of methods and results.

PubMed

Unger, J P; Killingsworth, J R

1986-01-01

In the aftermath of the Alma Ata conference, three types of Primary Health Care (PHC), have been identified. Comprehensive PHC (CPHC) and Basic PHC (BPHC) both have a wide scope of activities, BPHC however does not include water and sanitation activities. Only one year after the Alma Ata conference, CPHC was attacked as not 'feasible' and selective PHC (SPHC) was offered as an interim alternative. SPHC only addresses 5 to 8 diseases, almost all of them falling within the realm of pediatrics. Our article critically analyses the methods and results of SPHC. It contrasts the lack of supportive data for SPHC and its methodological deficiencies with the extent of its adoption by bilateral cooperation agencies, foundations, academic and research institutions, and international agencies. We suggest that rather than health factors, the major determinants of this adoption have been political and economical constraints acting upon decision makers exposed to a similar training in public health.

Oxygen Toxicity and Special Operations Forces Diving: Hidden and Dangerous

PubMed Central

Wingelaar, Thijs T.; van Ooij, Pieter-Jan A. M.; van Hulst, Rob A.

2017-01-01

In Special Operations Forces (SOF) closed-circuit rebreathers with 100% oxygen are commonly utilized for covert diving operations. Exposure to high partial pressures of oxygen (PO2) could cause damage to the central nervous system (CNS) and pulmonary system. Longer exposure time and higher PO2 leads to faster development of more serious pathology. Exposure to a PO2 above 1.4 ATA can cause CNS toxicity, leading to a wide range of neurologic complaints including convulsions. Pulmonary oxygen toxicity develops over time when exposed to a PO2 above 0.5 ATA and can lead to inflammation and fibrosis of lung tissue. Oxygen can also be toxic for the ocular system and may have systemic effects on the inflammatory system. Moreover, some of the effects of oxygen toxicity are irreversible. This paper describes the pathophysiology, epidemiology, signs and symptoms, risk factors and prediction models of oxygen toxicity, and their limitations on SOF diving. PMID:28790955

Multi-epoch Measurements of the Galactic Center 6667 MHz) and the Blazar 0716+714 (1 & 3 MHz) taken from the Allen Telescope Array at Hat Creek Radio Observatory in 2013

NASA Astrophysics Data System (ADS)

Castellanos, Aaron; Harp, G.

2014-01-01

The Allen Telescope Array (ATA) is a 42 radio dish array located in Hat Creek, CA and is used to search for traces of Extraterrestrial Intelligence (SETI) and to study the interstellar medium. The ATA has taken multi-epoch measurements of the Galactic Center 6667 MHz) and the intraday variable Blazar 0716+714 (1 & 3MHz) and are imaged on 10 second timescales to search for intensity fluctuations on timescales 10s and beyond. We utilize software developed and focused on antenna system temperatures to minimize Radio Frequency Interference (RFI) in order to enhance calibration and signal variability. We will discuss potential radio bursts from the Galactic Center, possibly originating from the descent of the gas cloud G2 into the Galactic Center.

Five Years of SETI with the Allen Telescope Array: Lessons Learned

NASA Astrophysics Data System (ADS)

Harp, Gerald

2016-01-01

We discuss recent observations at the Allen Telescope Array (ATA) supporting a wide ranging Search for Extraterrestrial Intelligence (SETI). The ATA supports observations over the frequency range 1-10 GHz with three simultaneous phased array beams used in an anticoincidence detector for false positive rejection. Here we summarize observational results over the years 2011-2015 covering multiple campaigns of exoplanet stars, the galactic plane, infrared excess targets, etc. Approximately 2 x 108 signals were identified and classified over more than 5000 hours of observation. From these results we consider various approaches to the rapid identification of human generated interference in the process of the search for a signal with origins outside the radius of the Moon's orbit. We conclude that the multi-beam technique is superb tool for answering the very difficult question of the direction of origin of signals. Data-based simulations of future instruments with more than 3 beams are compared.

49 CFR 572.135 - Upper and lower torso assemblies and torso flexion test procedure.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 7 2014-10-01 2014-10-01 false Upper and lower torso assemblies and torso flexion... torso assemblies and torso flexion test procedure. (a) Upper/lower torso assembly. The test objective is... (drawing 880105-434), on resistance to articulation between the upper torso assembly (drawing 880105-300...

49 CFR 572.135 - Upper and lower torso assemblies and torso flexion test procedure.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 7 2012-10-01 2012-10-01 false Upper and lower torso assemblies and torso flexion... torso assemblies and torso flexion test procedure. (a) Upper/lower torso assembly. The test objective is... (drawing 880105-434), on resistance to articulation between the upper torso assembly (drawing 880105-300...

49 CFR 572.125 - Upper and lower torso assemblies and torso flexion test procedure.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 7 2014-10-01 2014-10-01 false Upper and lower torso assemblies and torso flexion... assemblies and torso flexion test procedure. (a) Upper/lower torso assembly. The test objective is to...), and abdominal insert (drawing 127-8210), on resistance to articulation between upper torso assembly...

49 CFR 572.135 - Upper and lower torso assemblies and torso flexion test procedure.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 7 2013-10-01 2013-10-01 false Upper and lower torso assemblies and torso flexion... torso assemblies and torso flexion test procedure. (a) Upper/lower torso assembly. The test objective is... (drawing 880105-434), on resistance to articulation between the upper torso assembly (drawing 880105-300...

49 CFR 572.125 - Upper and lower torso assemblies and torso flexion test procedure.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 7 2011-10-01 2011-10-01 false Upper and lower torso assemblies and torso flexion... assemblies and torso flexion test procedure. (a) Upper/lower torso assembly. The test objective is to...), and abdominal insert (drawing 127-8210), on resistance to articulation between upper torso assembly...

49 CFR 572.125 - Upper and lower torso assemblies and torso flexion test procedure.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 7 2012-10-01 2012-10-01 false Upper and lower torso assemblies and torso flexion... assemblies and torso flexion test procedure. (a) Upper/lower torso assembly. The test objective is to...), and abdominal insert (drawing 127-8210), on resistance to articulation between upper torso assembly...

49 CFR 572.135 - Upper and lower torso assemblies and torso flexion test procedure.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 7 2011-10-01 2011-10-01 false Upper and lower torso assemblies and torso flexion... torso assemblies and torso flexion test procedure. (a) Upper/lower torso assembly. The test objective is... (drawing 880105-434), on resistance to articulation between the upper torso assembly (drawing 880105-300...

49 CFR 572.125 - Upper and lower torso assemblies and torso flexion test procedure.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 7 2013-10-01 2013-10-01 false Upper and lower torso assemblies and torso flexion... assemblies and torso flexion test procedure. (a) Upper/lower torso assembly. The test objective is to...), and abdominal insert (drawing 127-8210), on resistance to articulation between upper torso assembly...

Less is More: Comparing the 2015 and 2009 American Thyroid Association Guidelines for Thyroid Nodules and Cancer.

PubMed

Kim, Brian W; Yousman, Wina; Wong, Wei Xiang; Cheng, Cheng; McAninch, Elizabeth A

2016-06-01

The American Thyroid Association (ATA) has recently revised its guidance pertaining to thyroid nodules and follicular cell-derived thyroid cancer. The 2015 guidelines are massive in both scope and scale, with changes in the organizational approach to risk stratification of nodules and cancer, as well as multiple sections covering new material. This review highlights the major structural and organizational changes, focusing attention on the most dramatically changed recommendations, that is, those recommendations that clinicians will find striking because they call for significant divergence from prior clinical practice. The revised approach to thyroid nodule risk stratification is based on sonographic pattern, with an emphasis on pattern rather than growth in the long-term surveillance of nodules. Accumulating data have also been incorporated into an updated risk stratification scheme for thyroid cancer that increases the size of the low-risk pool, in part because low-volume lymph nodal metastases are now considered low risk. The most fundamentally altered recommendation is that lobectomy might be considered as the initial surgical approach for follicular cell-derived thyroid cancers from 1 to 4 cm in size. The underlying theme of the 2015 ATA guidelines is that "less is more." As these new recommendations are adopted, fewer fine-needle aspiration biopsies will need to be done, less extensive surgeries will become more common, less radioactive iodine will be used either for treatment or for diagnostics, and less stimulated thyroglobulin testing will be done. Mastery of these guidelines will help clinicians know when it is reasonable to do less, thus providing responsibly individualized therapy for their patients.

49 CFR 572.165 - Upper and lower torso assemblies and torso flexion test procedure.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 7 2012-10-01 2012-10-01 false Upper and lower torso assemblies and torso flexion... assemblies and torso flexion test procedure. (a) Upper/lower torso assembly. The test objective is to... (specified in 49 CFR 572.125(a)), on resistance to articulation between the upper torso assembly (drawing 167...

49 CFR 572.165 - Upper and lower torso assemblies and torso flexion test procedure.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 7 2013-10-01 2013-10-01 false Upper and lower torso assemblies and torso flexion... assemblies and torso flexion test procedure. (a) Upper/lower torso assembly. The test objective is to... (specified in 49 CFR 572.125(a)), on resistance to articulation between the upper torso assembly (drawing 167...

49 CFR 572.165 - Upper and lower torso assemblies and torso flexion test procedure.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 7 2010-10-01 2010-10-01 false Upper and lower torso assemblies and torso flexion... assemblies and torso flexion test procedure. (a) Upper/lower torso assembly. The test objective is to... (specified in 49 CFR 572.125(a)), on resistance to articulation between the upper torso assembly (drawing 167...

49 CFR 572.165 - Upper and lower torso assemblies and torso flexion test procedure.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 7 2011-10-01 2011-10-01 false Upper and lower torso assemblies and torso flexion... assemblies and torso flexion test procedure. (a) Upper/lower torso assembly. The test objective is to... (specified in 49 CFR 572.125(a)), on resistance to articulation between the upper torso assembly (drawing 167...

49 CFR 572.165 - Upper and lower torso assemblies and torso flexion test procedure.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 7 2014-10-01 2014-10-01 false Upper and lower torso assemblies and torso flexion... assemblies and torso flexion test procedure. (a) Upper/lower torso assembly. The test objective is to... (specified in 49 CFR 572.125(a)), on resistance to articulation between the upper torso assembly (drawing 167...

Neuropsychiatric systemic lupus erythematosus is associated with imbalance in interleukin 10 promoter haplotypes

PubMed Central

Rood, M; Keijsers, V; van der Linden, M W; Tong, T; Borggreve, S; Verweij, C; Breedveld, F; Huizinga, T

1999-01-01

OBJECTIVE—To investigate the association of interleukin 10 (IL10) promoter polymorphisms and neuropsychiatric manifestations of systemic lupus erythematosus (SLE).
METHODS—IL10 haplotypes of 11 healthy volunteers were cloned to confirm that in the Dutch population, only the three common haplotypes (-1082/-819/-592) GCC, ACC and ATA exist. The IL10 promoter polymorphisms of 92 SLE patients and 162 healthy controls were determined. The medical records of the SLE patients were screened for the presence of neuropsychiatric involvement.
RESULTS—All cloned haplotypes were either GCC, ACC or ATA. Forty two SLE patients had suffered from neuropsychiatric manifestations (NP-SLE). In NP-SLE patients, the frequency of the ATA haplotype is 30% versus 18% in the controls and 17% in the non-NP-SLE group (odds ratios 1.9, p=0.02, and 2.1, p=0.04, respectively), whereas the GCC haplotype frequency is lower in the NP-SLE group compared with controls and non-NP-SLE patients (40% versus 55% and 61%, odds ratios 0.6, p=0.02 and 0.4 p=0.006). The odds ratio for the presence of NP-SLE is inversely proportional to the number of GCC haplotypes per genotype when the NP-SLE group is compared with non-NP-SLE patients.
CONCLUSIONS—The IL10 locus is associated with neuropsychiatric manifestations in SLE. This suggests that IL10 is implicated in the immunopathogenesis of neuropsychiatric manifestations in SLE.

 Keywords: systemic lupus erythematosus; neuropsychiatric manifestations; genetics; interleukin 10 promoter haplotypes PMID:10343522

Hydrogen gas alleviates oxygen toxicity by reducing hydroxyl radical levels in PC12 cells

PubMed Central

Yu, Junchao; Yu, Qiuhong; Liu, Yaling; Zhang, Ruiyun; Xue, Lianbi

2017-01-01

Hyperbaric oxygen (HBO) therapy through breathing oxygen at the pressure of above 1 atmosphere absolute (ATA) is useful for varieties of clinical conditions, especially hypoxic-ischemic diseases. Because of generation of reactive oxygen species (ROS), breathing oxygen gas at high pressures can cause oxygen toxicity in the central nervous system, leading to multiple neurological dysfunction, which limits the use of HBO therapy. Studies have shown that Hydrogen gas (H2) can diminish oxidative stress and effectively reduce active ROS associated with diseases. However, the effect of H2 on ROS generated from HBO therapy remains unclear. In this study, we investigated the effect of H2 on ROS during HBO therapy using PC12 cells. PC12 cells cultured in medium were exposed to oxygen gas or mixed oxygen gas and H2 at 1 ATA or 5 ATA. Cells viability and oxidation products and ROS were determined. The data showed that H2 promoted the cell viability and inhibited the damage in the cell and mitochondria membrane, reduced the levels of lipid peroxidation and DNA oxidation, and selectively decreased the levels of •OH but not disturbing the levels of O2•-, H2O2, or NO• in PC12 cells during HBO therapy. These results indicated that H2 effectively reduced •OH, protected cells against oxygen toxicity resulting from HBO therapy, and had no effect on other ROS. Our data supported that H2 could be potentially used as an antioxidant during HBO therapy. PMID:28362819

75 FR 61818 - Eighty-Third Meeting: RTCA Special Committee 159: Global Positioning System (GPS).

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-06

... & Hilton-ATA Room. All Day, Working Group 7, GPS/Antennas, ARINC Room. Friday, October 29 Plenary Session...) GPS/Antennas (WG-7) Review of EUROCAE Activities. Nav and ADS-B Out Equipment Requirements--Discussion...

Synthesis and Structure of Hexamolybdobisorganoarsonates.

DTIC Science & Technology

1976-11-01

lU tnm s) —.~ ---- ---~~.“ . --. - ~~~ - -“ —‘ ‘ - ~~~ - — /~ ~132~ waki L .Aajdovi~ ”, J.K.Ata1ick, M.T. ~~’oPe s - • C O . Quicksall~ - - 544 1

76 FR 19517 - Orders Limiting Scheduled Operations at John F. Kennedy International Airport, LaGuardia Airport...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-07

... Liberty International Airport; High Density Rule at Reagan National Airport AGENCY: Federal Aviation... support for the ATA request for waiver. FAA Analysis Under the FAA's High Density Rule and Orders limiting...

American transit safety award : award winning safety program

DOT National Transportation Integrated Search

1950-01-01

Prepared ca. 1950. As the result of the widespread interest in safety evident among companies at meetings of the ATA Small Operations Division, the Division's Administrative Committee considered it desirable to put together a compilation of safety pr...

Collaboration as a Strategy to Transform the Impact of EPO Efforts in the New York Center for Astrobiology

NASA Astrophysics Data System (ADS)

Svirsky, A.; Rogers, K. L.; Meissner, M.; Busby, G.; Roberge, W.

2014-12-01

The New York Center for Astrobiology (NYCA) EPO effort is a collaboration combining expertise in evaluation and assessment of STEM educational modules with disciplinary expertise in astrobiology. In practice, the NYCA partners with external experts in professional development, informal education and evaluation to assist in developing and implementing certain programs of the NYCA EPO activities. Two specific program initiatives of the NYCA EPO effort offer excellent examples of programs with strong science content knowledge as well as using effective tools to address the NSF impact categories. These are the ExxonMobil Bernard Harris Summer Science Camp (EMBHSSC, in conjunction with RPI's STEM Pipeline Initiative) and the Astrobiology Teachers Academy (ATA). The EMBHSSC for middle school students focuses on NASA astrobiology initiatives around the "Quest for Life" theme. The Camp has a comprehensive evaluation component and uses pre-and post- assessment of student knowledge and interest in STEM. Recent data suggest that every student has shown a measurable gain in these areas. The ATA is a weeklong summer intensive professional development program for P-12 STEM teachers that combines discipline scientists in the NYCA with an external evaluation organization, the Association for the Cooperative Advancement of Science and Education (ACASE). The goal is for teachers to develop a new learning module for a course they teach that uses astrobiology as a content focus to engage students. The Academy has scientists collaborating with teachers in this effort, providing content and assistance in designing instructional activities. Assessments are woven into the fabric of the work in a few ways: 1. There is a purposeful focus on assessment as part of the learning module, and the content of the ATA; 2. ACASE offers teachers a tool for tracking their students' attainment of the learning goals identified in their learning module; 3. There are daily evaluations of the teachers' experiences to enable mid-course corrections, and a final evaluation of the ATA at the end of the experience. NYCA scientists support the approach of working collaboratively with external experts in evaluation as a paradigm for EPO activities sponsored by NASA. Our presentation will highlight the myriad of tools used to measure outcomes of these activities.

Tests of an alternate mobile transporter and extravehicular activity assembly procedure for the Space Station Freedom truss

NASA Technical Reports Server (NTRS)

Heard, Walter L., Jr.; Watson, Judith J.; Lake, Mark S.; Bush, Harold G.; Jensen, J. Kermit; Wallsom, Richard E.; Phelps, James E.

1992-01-01

Results are presented from a ground test program of an alternate mobile transporter (MT) concept and extravehicular activity (EVA) assembly procedure for the Space Station Freedom (SSF) truss keel. A three-bay orthogonal tetrahedral truss beam consisting of 44 2-in-diameter struts and 16 nodes was assembled repeatedly in neutral buoyancy by pairs of pressure-suited test subjects working from astronaut positioning devices (APD's) on the MT. The truss bays were cubic with edges 15 ft long. All the truss joint hardware was found to be EVA compatible. The average unit assembly time for a single pair of experienced test subjects was 27.6 sec/strut, which is about half the time derived from other SSF truss assembly tests. A concept for integration of utility trays during truss assembly is introduced and demonstrated in the assembly tests. The concept, which requires minimal EVA handling of the trays, is shown to have little impact on overall assembly time. The results of these tests indicate that by using an MT equipped with APD's, rapid EVA assembly of a space station-size truss structure can be expected.

An Interactive Method to Solve Infeasibility in Linear Programming Test Assembling Models

ERIC Educational Resources Information Center

Huitzing, Hiddo A.

2004-01-01

In optimal assembly of tests from item banks, linear programming (LP) models have proved to be very useful. Assembly by hand has become nearly impossible, but these LP techniques are able to find the best solutions, given the demands and needs of the test to be assembled and the specifics of the item bank from which it is assembled. However,…

75 FR 14482 - Fifty-First Meeting: RTCA Special Committee 186: Automatic Dependent Surveillance-Broadcast (ADS-B)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-25

..., WG-1, Wake Vortex, ARINC Room. RTCA--All Day, WG-4, Application Technical Requirements, Colson Board... Vortex, MacIntosh-NBAA Room & Hilton-ATA Room. RTCA--All Day, WG-4, Application Technical Requirements...

78 FR 41277 - Airworthiness Directives; Piper Aircraft, Inc. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-10

... through 4697520. (d) Subject Joint Aircraft System Component (JASC)/Air Transport Association (ATA) of... fluorosilicone (orange) fuel vent valve following Part III of Piper Aircraft, Inc. Mandatory Service Bulletin No... Airworthiness Directives; Piper Aircraft, Inc. Airplanes AGENCY: Federal Aviation Administration (FAA), DOT...

ECOLOGICAL STRUCTURE AMONG MIGRANT AND RESIDENT SEABIRDS OF THE SCOTIA-WEDDELL CONFLUENCE REGION

EPA Science Inventory

Report quantitatively assesses seasonal changes in community structure and habitat selection among seabirds in the Scotia-Weddell Confluence region, Antarctica. iscussed are biological and physical factors underlying the patterns. ata were derived from strip-transects on closely-...

PROCEEDINGS OF THE WORKSHOP GEOMEMBRANE SEAMING: DATA ACQUISITION AND CONTROL

EPA Science Inventory

The U.S. Environmental Protection Agency's Risk Reduction Engineering Laboratory, in cooperation with the Geosynthetic Research Institute, sponsored a workshop on Geomembrane Wedge Welding Seaming: ata Acquisition and Control on April 22, 1993. he workshop was held at the Andrew ...

Frequency distribution of interleukin-10 haplotypes (-1082 A>G, -819 C>T, and -592 C>A) in a Mexican population.

PubMed

Vázquez-Villamar, M; Palafox-Sánchez, C A; Hernández-Bello, J; Muñoz-Valle, J F; Valle, Y; Cruz, A; Alatorre-Meza, A I; Oregon-Romero, E

2016-11-03

Interleukin 10 (IL-10) is an immunoregulatory cytokine with multiple roles in the immune system. Three single nucleotide polymorphisms at positions -1082 (A>G), -819 (C>T), and -592 (C>A) in the promoter region of the IL10 gene are believed to be associated with different inflammatory, infectious, and autoimmune diseases. These polymorphisms exhibit a strong linkage disequilibrium (LD) and form three principal haplotypes (GCC, ACC, and ATA). The GCC and ATA haplotypes have been associated with high and low levels of IL-10 production, respectively. The aim of this study was to establish the allele and haplotype frequencies of the IL10 polymorphisms in Mestizos from western Mexico. SNPs were analyzed in 340 healthy unrelated Mestizos from western Mexico by polymerase chain reaction-restriction fragment length polymorphism. The studied population presented significant differences, in the distribution of IL10 polymorphisms, from the Asian, African, and European populations. We also observed a strong LD within -1082 A>G, -819 C>T, and -592 C>A (100% pc = 7.735 x 10 -18 ). The haplotypes ACC (45.4%), ATA (22.0%), GTA (14.9%), and GCC (13.9%) were most frequently observed in this population. The haplotype frequencies, however, differed from those reported previously in Mestizos from central Mexico, Asians, Africans, and European Caucasians, suggesting a differential gene flow in the Mexican Mestizo population. This could account for the genetic variability between Mexicans and populations of other ethnicities. The study of these polymorphisms and their haplotypes could help in expanding our knowledge to design future disease-risk studies on the western Mexican population.

Participation of PLA2 and PLC in DhL-induced activation of Rhinella arenarum oocytes.

PubMed

Zapata-Martínez, J; Medina, M F; Gramajo-Bühler, M C; Sánchez-Toranzo, G

2016-08-01

Rhinella arenarum oocytes can be artificially activated, a process known as parthenogenesis, by a sesquiterpenic lactone of the guaianolide group, dehydroleucodine (DhL). Transient increases in the concentration of cytosolic Ca2+ are essential to trigger egg activation events. In this sense, the 1-4-5 inositol triphosphate receptors (IP3R) seem to be involved in the Ca2+ transient release induced by DhL in this species. We analyzed the involvement of phosphoinositide metabolism, especially the participation of phospholipase A2 (PLA2) and phospholipase C (PLC) in DhL-induced activation. Different doses of quinacrine, aristolochic acid (ATA) (PLA2 inhibitors) or neomycin, an antibiotic that binds to PIP2, thus preventing its hydrolysis, were used in mature Rhinella arenarum oocytes. In order to assay the participation of PI-PLC and PC- PLC we used U73122, a competitive inhibitor of PI-PLC dependent events and D609, an inhibitor of PC-PLC. We found that PLA2 inhibits quinacrine more effectively than ATA. This difference could be explained by the fact that quinacrine is not a specific inhibitor for PLA2 while ATA is specific for this enzyme. With respect to the participation of PLC, a higher decrease in oocyte activation was detected when cells were exposed to neomycin. Inhibition of PC-PLC with D609 and IP-PLC with U73122 indicated that the last PLC has a significant participation in the effect of DhL-induced activation. Results would indicate that DhL induces activation of in vitro matured oocytes of Rhinella arenarum by activation of IP-PLC, which in turn may induce IP3 formation which produces Ca2+ release.

Structural Basis for Toughness and Flexibility in the C-terminal Passenger Domain of an Acinetobacter Trimeric Autotransporter Adhesin*

PubMed Central

Koiwai, Kotaro; Hartmann, Marcus D.; Linke, Dirk; Lupas, Andrei N.; Hori, Katsutoshi

2016-01-01

Trimeric autotransporter adhesins (TAAs) on the cell surface of Gram-negative pathogens mediate bacterial adhesion to host cells and extracellular matrix proteins. However, AtaA, a TAA in the nonpathogenic Acinetobacter sp. strain Tol 5, shows nonspecific high adhesiveness to abiotic material surfaces as well as to biotic surfaces. It consists of a passenger domain secreted by the C-terminal transmembrane anchor domain (TM), and the passenger domain contains an N-terminal head, N-terminal stalk, C-terminal head (Chead), and C-terminal stalk (Cstalk). The Chead-Cstalk-TM fragment, which is conserved in many Acinetobacter TAAs, has by itself the head-stalk-anchor architecture of a complete TAA. Here, we show the crystal structure of the Chead-Cstalk fragment, AtaA_C-terminal passenger domain (CPSD), providing the first view of several conserved TAA domains. The YadA-like head (Ylhead) of the fragment is capped by a unique structure (headCap), composed of three β-hairpins and a connector motif; it also contains a head insert motif (HIM1) before its last inner β-strand. The headCap, Ylhead, and HIM1 integrally form a stable Chead structure. Some of the major domains of the CPSD fragment are inherently flexible and provide bending sites for the fiber between segments whose toughness is ensured by topological chain exchange and hydrophobic core formation inside the trimer. Thus, although adherence assays using in-frame deletion mutants revealed that the characteristic adhesive sites of AtaA reside in its N-terminal part, the flexibility and toughness of the CPSD part provide the resilience that enables the adhesive properties of the full-length fiber across a wide range of conditions. PMID:26698633

PiHi Observations at the ATA, Conventional and Unconventional SETI

NASA Astrophysics Data System (ADS)

Harp, Gerald; Wilcox, B.; Arbunich, J.; Blair, S.; Backus, P. R.; Tarter, J. C.; Shostak, S.; Jordan, J.; Kilsdonk, T.; Ackermann, R. F.; Ross, J.; ATA Team

2010-01-01

Many radio SETI searches focus on the frequency range where the HI (1.42 GHz) and OH lines (1.6-1.7 GHz) lines are landmarks delineating the water hole This is only a small fraction of the terrestrial microwave window (TMW) from 1-10 GHz. This survey occurs near the center of the TMW at 4.462336275 GHz or π times the HI frequency. We call this the PiHI ("pie high") survey. The inspiration for PiHI observations comes from Carl Sagan in his book, Contact. This survey builds upon and extends a previous survey at PiHI (Blair, D. G. et al. (1992), MNRAS, 257, 105) with greater sensitivity, resolution, and coverage. We survey the nearest 94 main sequence stars in the HabCat catalog (Turnbull, M. C. and Tarter, J. C. (2003), ApJS, 145, 181) with spectral classes between F9 and G7 (max. radius 62 pc). The ATA's flexibility allows simultaneous measurements of targeted observations on stars (with beamformers) and 1° FOV "blind” observations of the areas around target stars (with imaging correlator). The targeted observations are carried out with a high resolution (0.7 Hz) spectrometer and integration times on the order of 200 s. The spectral imaging correlator measures a 50 x 50 grid of points with 3 kHz spectral resolution. This survey shows several signals of minor interest were discovered, though none of the signals reported are continuously "on,” which is an important characteristic for the positive identification of an ETI signal. The ATA has been funded through generous grants from the Paul G. Allen Family Foundation, the SETI Institute, UC Berkeley, the National Science Foundation (Grant No. 0540599), Sun Microsystems, Xilinx, Nathan Myhrvold, Greg Papadopoulos, and other corporations and individual donors.

Risk Profile of the RET A883F Germline Mutation: An International Collaborative Study.

PubMed

Mathiesen, Jes Sloth; Habra, Mouhammed Amir; Bassett, John Howard Duncan; Choudhury, Sirazum Mubin; Balasubramanian, Sabapathy Prakash; Howlett, Trevor A; Robinson, Bruce G; Gimenez-Roqueplo, Anne-Paule; Castinetti, Frederic; Vestergaard, Peter; Frank-Raue, Karin

2017-06-01

The A883F germline mutation of the rearranged during transfection (RET) proto-oncogene causes multiple endocrine neoplasia 2B. In the revised American Thyroid Association (ATA) guidelines for the management of medullary thyroid carcinoma (MTC), the A883F mutation has been reclassified from the highest to the high-risk level, although no well-defined risk profile for this mutation exists. To create a risk profile for the A883F mutation for appropriate classification among the ATA risk levels. Retrospective analysis. International collaboration. Included were 13 A883F carriers. The intervention was thyroidectomy. Earliest age of MTC, regional lymph node metastases, distant metastases, age-related penetrance of MTC and pheochromocytoma (PHEO), overall and disease-specific survival, and biochemical cure rate. One and three carriers were diagnosed at age 7 to 9 years (median, 7.5 years) with a normal thyroid and C-cell hyperplasia, respectively. Nine carriers were diagnosed with MTC at age 10 to 39 years (median, 19 years). The earliest age of MTC, regional lymph node metastasis, and distant metastasis was 10, 20, and 20 years, respectively. Fifty percent penetrance of MTC and PHEO was achieved by age 19 and 34 years, respectively. Five- and 10-year survival rates (both overall and disease specific) were 88% and 88%, respectively. Biochemical cure for MTC at latest follow-up was achieved in 63% (five of eight carriers) with pertinent data. MTC of A883F carriers seems to have a more indolent natural course compared with that of M918T carriers. Our results support the classification of the A883F mutation in the ATA high-risk level. Copyright © 2017 Endocrine Society

1. MISSILE TEST AND ASSEMBLY BUILDING, FRONT, LOOKING SOUTH. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. MISSILE TEST AND ASSEMBLY BUILDING, FRONT, LOOKING SOUTH. - NIKE Missile Base SL-40, Missile Test & Assembly Building, South end of launch area, northeast of Generator Building No. 3, Hecker, Monroe County, IL

Swing-arm beam erector (SABER) concept for single astronaut assembly of space structure

NASA Technical Reports Server (NTRS)

Watson, J. J.; Heard, W. L., Jr.; Jensen, J. K.

1985-01-01

Results are presented of tests conducted to evaluate a mobile work station/assembly fixture concept that would mechanically assist an astronaut in the on-orbit manual assembly of erectable truss-beams. The concept eliminates astronaut manual translation by use of a motorized work platform with foot restraints. The tests involved assembly of a tetrahedral truss-beam by a test subject in simulated zero gravity (neutral bouyancy in water). A three-bay truss-beam was assembled from 30 aluminum struts with quick-attachment structural joints. The results show that average on-orbit assembly rates of 2.1 struts per minute can be expected for struts of the size employed in these tests.

76 FR 56318 - Parts and Accessories Necessary for Safe Operation; Saddle-Mount Braking Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-13

... a petition for rulemaking from the Automobile Carriers Conference (ACC) of the American Trucking... antilock braking systems. ACC Automobile Carriers Conference. ATA American Trucking Associations. ATC ATC... Carrier Safety Regulations. NATA National Automobile Transporters Association. NPRM notice of proposed...

Pulmonary function in men after oxygen breathing at 3.0 ATA for 3.5 h

NASA Technical Reports Server (NTRS)

Clark, J. M.; Jackson, R. M.; Lambertsen, C. J.; Gelfand, R.; Hiller, W. D. B.; Unger, M.

1991-01-01

A complete description of pulmonary measurements obtained after continuous O2 exposure of 13 healthy men at 3.0 ATA for 3.5 h is presented. Measurements included flow-volume loops, spirometry, and airway resistance(n = 12); CO diffusing capacity (n = 11); closing volumes (n= 6); and air vs. HeO2 forced vital capacity maneuvers (n = 5). The average difference in maximum mid expiratory flows at 50 percent vital capacity on air and HeO2 was found to be significantly reduced postexposure by 18 percent. Raw and CO diffusing capacity were not changed postexposure. It is concluded that the relatively large change in forced expiratory flow at 25-75 percent of vital capacity compared with the mean forced expiratory volume in 1 s, the reduction in density dependence of flow, and the normal Raw postexposure are all consistent with flow limitation in peripheral airways as a major cause of the observed reduction in expiratory flow.

Computer-aided system for diagnosing thyroid nodules on ultrasound: A comparison with radiologist-based clinical assessments.

PubMed

Gao, Luying; Liu, Ruyu; Jiang, Yuxin; Song, Wenfeng; Wang, Ying; Liu, Jia; Wang, Juanjuan; Wu, Dongqian; Li, Shuai; Hao, Aimin; Zhang, Bo

2018-04-01

The purpose of this study was to compare the diagnostic efficiency of a thyroid ultrasound computer-aided diagnosis (CAD) system with that of 1 radiologist. This study retrospectively reviewed 342 surgically resected thyroid nodules from July 2013 to December 2013 at our center. The nodules were assessed on typical ultrasound images using the CAD system and reviewed by 1 experienced radiologist. The radiologist stratified the risk of malignancy using the Thyroid Imaging Reporting and Data Systems (TIRADS) and the American Thyroid Association (ATA) guidelines. The radiologist, using TI-RADS and ATA guidelines, performed better than the CAD system (P < .01). The sensitivity of the CAD system was similar to that of an experienced radiologist (P > .05; P < .01; and P > .05). However, we found that the CAD system had lower specificity (P < .01). The sensitivity of a thyroid ultrasound CAD system in differentiating nodules was similar to that of an experienced radiologist. However, the CAD system had lower specificity. © 2017 Wiley Periodicals, Inc.

Effects of household detergent on anaerobic fermentation of kitchen wastewater from food waste disposer.

PubMed

Lee, K H; Park, K Y; Khanal, S K; Lee, J W

2013-01-15

This study examines the effects of household detergent on anaerobic methane fermentation of wastewater from food waste disposers (FWDs). Anaerobic toxicity assay (ATA) demonstrated that methane production substantially decreased at a higher detergent concentration. The Gompertz three-parameter model fitted well with the ATA results, and both the extent of methane production (M) and methane production rate (R(m)) obtained from the model were strongly affected by the concentration of the detergent. The 50% inhibitory concentration (IC(50)) of the detergent was 603 mg/L based on R(m). Results from fatty acid methyl esters (FAMEs) analysis of microbial culture revealed that deterioration of methane fermentation was attributed to impaired structure of anaerobic microbial membrane due to detergent. This study suggests that wastewater from FWD could be used for methane production, but it is necessary to reduce the concentration of detergent prior to anaerobic fermentation. Copyright © 2012 Elsevier B.V. All rights reserved.

Love-type surface acoustic wave on Y-X LiTaO3 with amorphous Ta2O5 thin film

NASA Astrophysics Data System (ADS)

Kakio, Shoji; Fukasawa, Haruka; Hosaka, Keiko

2015-07-01

In this study, to obtain a substrate structure with a lower phase velocity, the propagation properties of a Love-type surface acoustic wave (Love SAW) on Y-X LiTaO3 (LT) with an amorphous tantalum pentoxide (a-Ta2O5) thin film were investigated using a simple delay line and a resonator with a wavelength λ of 8 µm. The insertion loss of a simple delay line was decreased markedly by loading with an a-Ta2O5 film owing to a transformation from a leaky SAW (LSAW) to a non-leaky Love SAW. A phase velocity of 3,340 m/s, a coupling factor of 5.8%, and a propagation loss of 0.03 dB/λ were obtained for a normalized thickness h/λ of 0.120. Moreover, the resonance properties of the Love SAW were almost equal or superior to those for an LSAW on Al/36° Y-X LT, except for the fractional bandwidth.

4. MISSILE TEST AND ASSEMBLY BUILDING, LEFT SIDE, LOOKING NORTH. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. MISSILE TEST AND ASSEMBLY BUILDING, LEFT SIDE, LOOKING NORTH. - NIKE Missile Base SL-40, Missile Test & Assembly Building, South end of launch area, northeast of Generator Building No. 3, Hecker, Monroe County, IL

2. MISSILE TEST AND ASSEMBLY BUILDING, RIGHT SIDE, LOOKING WEST. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. MISSILE TEST AND ASSEMBLY BUILDING, RIGHT SIDE, LOOKING WEST. - NIKE Missile Base SL-40, Missile Test & Assembly Building, South end of launch area, northeast of Generator Building No. 3, Hecker, Monroe County, IL

3. MISSILE TEST AND ASSEMBLY BUILDING, REAR SIDE, LOOKING NORTH. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. MISSILE TEST AND ASSEMBLY BUILDING, REAR SIDE, LOOKING NORTH. - NIKE Missile Base SL-40, Missile Test & Assembly Building, South end of launch area, northeast of Generator Building No. 3, Hecker, Monroe County, IL

Matched-pair analyses of resting and dynamic morphology between Monarc and TVT-O procedures by ultrasound.

PubMed

Yang, Jenn-Ming; Yang, Shwu-Huey; Huang, Wen-Chen; Tzeng, Chii-Ruey

2013-07-01

To determine morphologic differences between Monarc and TVT-O procedures in axial and coronal planes by three- and four-dimensional (3D and 4D) ultrasound. Retrospective chart audits and ultrasound analyses were conducted on 128 women who had undergone either Monarc or TVT-O procedures for urodynamic stress incontinence. Thirty matched pairs of the two successful procedures were randomly selected and compared. Matched variables were age, parity, body mass index, cesarean status, menopausal status, and primary surgeries. Six-month postoperative 3D and 4D ultrasound results obtained at rest, on straining, and during coughing in these 60 women were analyzed. Assessed ultrasound parameters included the axial tape urethral distance (aTUD), axial central urethral echolucent area (aUCEA), axial tape angle (aTA), and coronal tape angle (cTA), all of which were measured at three equidistant points along the tapes. Paired t-tests were used to compare differences in ultrasound parameters between women after the two procedures and a P value <0.004 was considered significant after Bonferroni correction. At rest, women subjected to Monarc procedures had a significantly wider aTA at one-fourth of the tape and a wider cTA at one-, two-, and three-fourths of the tape than did those subjected to TVT-O procedures. There were no significant differences in other resting ultrasound parameters between these two procedures. Additionally, after both procedures women had comparable straining and coughing ultrasound manifestations as well as respective dynamic changes. Despite flatter resting tape angulations in women following Monarc procedures, both Monarc and TVT-O tapes had equivalent dynamic patterns and changes assessed by 4D ultrasound. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Cytokine expression before and after aspirin desensitization therapy in aspirin-exacerbated respiratory disease.

PubMed

Aktas, Ayse; Kurt, Emel; Gulbas, Zafer

2013-12-01

Aspirin exacerbated respiratory disease (AERD) is induced by acetylsalicylic acid (ASA) and/or nonsteroidal antiinflammatory drugs (NSAIDs). Effects of desensitization on many mediators have been examined previously, but few studies addressed the influence of desensitization on T lymphocytes and T lymphocyte-derived cytokines. This study was performed to examine peripheral blood lymphocyte (PBL) cytokine expression in aspirin-sensitive patients who have asthma before and after aspirin desensitization. In this study, the release of interleukin-2 (IL-2), interleukin-4 (IL-4), and interferon-gamma (IFN-γ) by CD4+ T lymphocytes prior to aspirin desensitization were also measured at intracellular levels, and expression of these cytokines after 1 month aspirin desensitization was evaluated. Twelve patients with AERD were included in the study. Two different control groups were formed, one consisted of 15 healthy people and second 12 aspirin tolerant asthmatic (ATA) patients using aspirin. A blood sample was collected prior to desensitization, and the tests were repeated by taking a second blood sample 1 month after the 4-day desensitization treatment. The proportion of lymphocytes secreting IFN-γ in the study group was 15.61 ± 4.40 % before desensitization and 15.08 ± 5.89 % after desensitization. The rate of IFN-γ secreting CD4+ T lymphocytes was 20.51 ± 4.41 % in the normal control group and 16.07 ± 5.7 % in the ATA group (p = 0.021). The ratio of CD4+ T lymphocyte secreting IFN-γ was reduced in patients with AERD before desensitization compared to normal control group (p = 0.040). The levels of IL-2, IL-4, and the subsets of lymphocyte were not different before and after desensitization compared to control groups.

A model for predicting sulcus-to-sulcus diameter in posterior chamber phakic intraocular lens candidates: correlation between ocular biometric parameters.

PubMed

Ghoreishi, Mohammad; Abdi-Shahshahani, Mehdi; Peyman, Alireza; Pourazizi, Mohsen

2018-02-21

The aim of this study was to determine the correlation between ocular biometric parameters and sulcus-to-sulcus (STS) diameter. This was a cross-sectional study of preoperative ocular biometry data of patients who were candidates for phakic intraocular lens (IOL) surgery. Subjects underwent ocular biometry analysis, including refraction error evaluation using an autorefractor and Orbscan topography for white-to-white (WTW) corneal diameter and measurement. Pentacam was used to perform WTW corneal diameter and measurements of minimum and maximum keratometry (K). Measurements of STS and angle-to-angle (ATA) were obtained using a 50-MHz B-mode ultrasound device. Anterior optical coherence tomography was performed for anterior chamber depth measurement. Pearson's correlation test and stepwise linear regression analysis were used to find a model to predict STS. Fifty-eight eyes of 58 patients were enrolled. Mean age ± standard deviation of sample was 28.95 ± 6.04 years. The Pearson's correlation coefficient between STS with WTW, ATA, mean K was 0.383, 0.492, and - 0.353, respectively, which was statistically significant (all P < 0.001). Using stepwise linear regression analysis, there is a statistically significant association between STS with WTW (P = 0.011) and mean K (P = 0.025). The standardized coefficient was 0.323 and - 0.284 for WTW and mean K, respectively. The stepwise linear regression analysis equation was: (STS = 9.549 + 0.518 WTW - 0.083 mean K). Based on our result, given the correlation of STS with WTW and mean K and potential of direct and essay measurement of WTW and mean K, it seems that current IOL sizing protocols could be estimating with WTW and mean K.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Renno, Nilton O.; Ruf, Christopher S., E-mail: renno@alum.mit.edu

Ruf et al. used the Deep Space Network (DSN) to search for the emission of non-thermal radiation by martian dust storms, theoretically predicted by Renno et al. They detected the emission of non-thermal radiation that they were searching for, but were surprised that it contained spectral peaks suggesting modulation at various frequencies and their harmonics. Ruf et al. hypothesized that the emission of non-thermal radiation was caused by electric discharges in a deep convective dust storm, modulated by Schumann resonances (SRs). Anderson et al. used the Allen Telescope Array (ATA) to search for similar emissions. They stated that they foundmore » only radio frequency interference (RFI) during their search for non-thermal emission by martian dust storms and implicitly suggested that the signal detected by Ruf et al. was also RFI. However, their search was not conducted during the dust storm season when deep convective storms are most likely to occur. Here, we show that the ubiquitous dust devils and small-scale dust storms that were instead likely present during their observations are too shallow to excite SRs and produce the signals detected by Ruf et al. We also show that the spectral and temporal behavior of the signals detected by Anderson et al. corroborates the idea that they originated from man-made pulse-modulated telecommunication signals rather than martian electric discharges. In contrast, an identical presentation of the signals detected by Ruf et al. demonstrates that they do not resemble man-made signals. The presentation indicates that the DSN signals were consistent with modulation by martian SRs, as originally hypothesized by Ruf et al. We propose that a more comprehensive search for electrostatic discharges be conducted with either the ATA or DSN during a future martian dust storm season to test the hypothesis proposed by Ruf et al.« less

The SXT conjugative element and linear prophage N15 encode toxin-antitoxin-stabilizing systems homologous to the tad-ata module of the Paracoccus aminophilus plasmid pAMI2.

PubMed

Dziewit, Lukasz; Jazurek, Magdalena; Drewniak, Lukasz; Baj, Jadwiga; Bartosik, Dariusz

2007-03-01

A group of proteic toxin-antitoxin (TA) cassettes whose representatives are widely distributed among bacterial genomes has been identified. These cassettes occur in chromosomes, plasmids, bacteriophages, and noncomposite transposons, as well as in the SXT conjugative element of Vibrio cholerae. The following four homologous loci were subjected to detailed comparative studies: (i) tad-ata from plasmid pAMI2 of Paracoccus aminophilus (the prototype of this group), (ii) gp49-gp48 from the linear bacteriophage N15 of Escherichia coli, (iii) s045-s044 from SXT, and (iv) Z3230-Z3231 from the genomic island of enterohemorrhagic Escherichia coli O157:H7 strain EDL933. Functional analysis revealed that all but one of these loci (Z3230-Z3231) are able to stabilize heterologous replicons, although the host ranges varied. The TA cassettes analyzed have the following common features: (i) the toxins are encoded by the first gene of each operon; (ii) the antitoxins contain a predicted helix-turn-helix motif of the XRE family; and (iii) the cassettes have two promoters that are different strengths, one which is located upstream of the toxin gene and one which is located upstream of the antitoxin gene. All four toxins tested are functional in E. coli; overexpression of the toxins (in the absence of antitoxin) results in a bacteriostatic effect manifested by elongation of bacterial cells and growth arrest. The toxins have various effects on cell viability, which suggests that they may recognize different intracellular targets. Preliminary data suggest that different cellular proteases are involved in degradation of antitoxins encoded by the loci analyzed.

Berthing mechanism final test report and program assessment

NASA Technical Reports Server (NTRS)

1988-01-01

The purpose is to document the testing performed on both hardware and software developed under the Space Station Berthing Mechanisms Program. Testing of the mechanism occurred at three locations. Several system components, e.g., actuators and computer systems, were functionally tested before assembly. A series of post assembly tests were performed. The post assembly tests, as well as the dynamic testing of the mechanism, are presented.

49 CFR 572.145 - Upper and lower torso assemblies and torso flexion test procedure.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 7 2012-10-01 2012-10-01 false Upper and lower torso assemblies and torso flexion... assemblies and torso flexion test procedure. (a) The test objective is to determine the resistance of the... upper and lower halves of the torso assembly (refer to § 572.140(a)(1)(iv)). (b)(1) When the upper half...

49 CFR 572.145 - Upper and lower torso assemblies and torso flexion test procedure.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 7 2011-10-01 2011-10-01 false Upper and lower torso assemblies and torso flexion... assemblies and torso flexion test procedure. (a) The test objective is to determine the resistance of the... upper and lower halves of the torso assembly (refer to § 572.140(a)(1)(iv)). (b)(1) When the upper half...

49 CFR 572.145 - Upper and lower torso assemblies and torso flexion test procedure.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 7 2013-10-01 2013-10-01 false Upper and lower torso assemblies and torso flexion... assemblies and torso flexion test procedure. (a) The test objective is to determine the resistance of the... upper and lower halves of the torso assembly (refer to § 572.140(a)(1)(iv)). (b)(1) When the upper half...

49 CFR 572.145 - Upper and lower torso assemblies and torso flexion test procedure.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 7 2014-10-01 2014-10-01 false Upper and lower torso assemblies and torso flexion... assemblies and torso flexion test procedure. (a) The test objective is to determine the resistance of the... upper and lower halves of the torso assembly (refer to § 572.140(a)(1)(iv)). (b)(1) When the upper half...

SSME component assembly and life management expert system

NASA Technical Reports Server (NTRS)

Ali, M.; Dietz, W. E.; Ferber, H. J.

1989-01-01

The space shuttle utilizes several rocket engine systems, all of which must function with a high degree of reliability for successful mission completion. The space shuttle main engine (SSME) is by far the most complex of the rocket engine systems and is designed to be reusable. The reusability of spacecraft systems introduces many problems related to testing, reliability, and logistics. Components must be assembled from parts inventories in a manner which will most effectively utilize the available parts. Assembly must be scheduled to efficiently utilize available assembly benches while still maintaining flight schedules. Assembled components must be assigned to as many contiguous flights as possible, to minimize component changes. Each component must undergo a rigorous testing program prior to flight. In addition, testing and assembly of flight engines and components must be done in conjunction with the assembly and testing of developmental engines and components. The development, testing, manufacture, and flight assignments of the engine fleet involves the satisfaction of many logistical and operational requirements, subject to many constraints. The purpose of the SSME Component Assembly and Life Management Expert System (CALMES) is to assist the engine assembly and scheduling process, and to insure that these activities utilize available resources as efficiently as possible.

Neutral buoyancy test evaluation of hardware and extravehicular activity procedures for on-orbit assembly of a 14 meter precision reflector

NASA Technical Reports Server (NTRS)

Heard, Walter L., Jr.; Lake, Mark S.

1993-01-01

A procedure that enables astronauts in extravehicular activity (EVA) to perform efficient on-orbit assembly of large paraboloidal precision reflectors is presented. The procedure and associated hardware are verified in simulated Og (neutral buoyancy) assembly tests of a 14 m diameter precision reflector mockup. The test article represents a precision reflector having a reflective surface which is segmented into 37 individual panels. The panels are supported on a doubly curved tetrahedral truss consisting of 315 struts. The entire truss and seven reflector panels were assembled in three hours and seven minutes by two pressure-suited test subjects. The average time to attach a panel was two minutes and three seconds. These efficient assembly times were achieved because all hardware and assembly procedures were designed to be compatible with EVA assembly capabilities.

5. MISSILE TEST AND ASSEMBLY BUILDING, FRONT AND RIGHT SIDES, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. MISSILE TEST AND ASSEMBLY BUILDING, FRONT AND RIGHT SIDES, LOOKING SOUTHEAST. - NIKE Missile Base SL-40, Missile Test & Assembly Building, South end of launch area, northeast of Generator Building No. 3, Hecker, Monroe County, IL

6. MISSILE TEST AND ASSEMBLY BUILDING, REAR AND LEFT SIDES, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. MISSILE TEST AND ASSEMBLY BUILDING, REAR AND LEFT SIDES, LOOKING NORTHWEST. - NIKE Missile Base SL-40, Missile Test & Assembly Building, South end of launch area, northeast of Generator Building No. 3, Hecker, Monroe County, IL

Optimal Testlet Pool Assembly for Multistage Testing Designs

ERIC Educational Resources Information Center

Ariel, Adelaide; Veldkamp, Bernard P.; Breithaupt, Krista

2006-01-01

Computerized multistage testing (MST) designs require sets of test questions (testlets) to be assembled to meet strict, often competing criteria. Rules that govern testlet assembly may dictate the number of questions on a particular subject or may describe desirable statistical properties for the test, such as measurement precision. In an MST…

78 FR 58973 - Airworthiness Directives; Dassault Aviation Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-25

... 2000EX type design are included in Dassault Aviation Falcon 2000EX (F2000EX) Aircraft Maintenance Manual... numbers. (d) Subject Air Transport Association (ATA) of America Code 05, Time Limits/ Maintenance Checks... to introduce a corrosion prevention control program, among other changes, to the maintenance...

76 FR 72495 - Alabama Metal Coil Securement Act; Petition for Determination of Preemption

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-23

...-0318] Alabama Metal Coil Securement Act; Petition for Determination of Preemption AGENCY: Federal Motor... the American Trucking Associations (ATA) requesting a determination that the State of Alabama's Metal..., Alabama's metal coil load securement certification requirements may have on interstate commerce. DATES...

Accessing the Classroom Discourse Community through Accountable Talk: English Learners' Voices

ERIC Educational Resources Information Center

Ardasheva, Yuliya; Howell, Penny B.; Vidrio Magaña, Margarita

2016-01-01

This case study draws on Gee's (1989) "D/discourse theory" to investigate English learners' (ELs') perspectives regarding Accountable Talk (AT)--a structured, discourse-intensive instructional approach--after a yearlong implementation in three content-based (mathematics) middle school classrooms. Interviews with 21 ELs (3 Advanced…

Economics Pupils

ERIC Educational Resources Information Center

Scott, Alexander; Straker-Cook, Dawn

1976-01-01

This paper contains survey information relating to the relative performance of economics pupils at"A" level, their feelings about the subject, and the type of teaching to which they are exposed. The primary concern is to stimulate debate about the issues raised. Journal is available from: Economics Association, Room 340, Hamilton House, Mabledon…

76 FR 75470 - Drivers of CMVs: Restricting the Use of Cellular Phones

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-02

... children and/or school personnel between home and school. This particular exemption is not based on any... said that this ``overly prescriptive'' regulatory wording would inhibit development of innovative... Association suggested allowing negligible movements to activate a hands-free mobile telephone. ATA recommended...

Building Assessment Survey and Evaluation Study: Quality Assurance Project Plan

EPA Pesticide Factsheets

This supplement describes QA/QC aspects of the implementation of the Office of Radiation and Indoor Air's BASE protocol including: recruitment of study buildings, execution of field studies in each building, and the processing and coordination of each building's ata for final submittal to EPA.

Diffusion barrier properties of single- and multilayered quasi-amorphous tantalum nitride thin films against copper penetration

NASA Astrophysics Data System (ADS)

Chen, G. S.; Chen, S. T.

2000-06-01

Tantalum-related thin films containing different amounts of nitrogen are sputter deposited at different argon-to-nitrogen flow rate ratios on (100) silicon substrates. Using x-ray diffractometry, transmission electron microscopy, composition and resistivity analyses, and bending-beam stress measurement technique, this work examines the impact of varying the nitrogen flow rate, particularly on the crystal structure, composition, resistivity, and residual intrinsic stress of the deposited Ta2N thin films. With an adequate amount of controlled, reactive nitrogen in the sputtering gas, thin films of the tantalum nitride of nominal formula Ta2N are predominantly amorphous and can exist over a range of nitrogen concentrations slightly deviated from stoichiometry. The single-layered quasi-amorphous Ta2N (a-Ta2N) thin films yield intrinsic compressive stresses in the range 3-5 GPa. In addition, the use of the 40-nm-thick a-Ta2N thin films with different nitrogen atomic concentrations (33% and 36%) and layering designs as diffusion barriers between silicon and copper are also evaluated. When subjected to high-temperature annealing, the single-layered a-Ta2N barrier layers degrade primarily by an amorphous-to-crystalline transition of the barrier layers. Crystallization of the single-layered stoichiometric a-Ta2N (Ta67N33) diffusion barriers occurs at temperatures as low as 450 °C. Doing so allows copper to preferentially penetrate through the grain boundaries or thermal-induced microcracks of the crystallized barriers and react with silicon, sequentially forming {111}-facetted pyramidal Cu3Si precipitates and TaSi2 Overdoping nitrogen into the amorphous matrix can dramatically increase the crystallization temperature to 600 °C. This temperature increase slows down the inward diffusion of copper and delays the formation of both silicides. The nitrogen overdoped Ta2N (Ta64N36) diffusion barriers can thus be significantly enhanced so as to yield a failure temperature 100 °C greater than that of the Ta67N33 diffusion barriers. Moreover, multilayered films, formed by alternately stacking the Ta67N33 and Ta64N36 layers with an optimized bilayer thickness (λ) of 10 nm, can dramatically reduce the intrinsic compressive stress to only 0.7 GPa and undergo high-temperature annealing without crystallization. Therefore, the Ta67N33/Ta64N36 multilayered films exhibit a much better barrier performance than the highly crystallization-resistant Ta64N36 single-layered films.

Surrogate fuel assembly multi-axis shaker tests to simulate normal conditions of rail and truck transport

DOE Office of Scientific and Technical Information (OSTI.GOV)

McConnell, Paul E.; Koenig, Greg John; Uncapher, William Leonard

2016-05-01

This report describes the third set of tests (the “DCLa shaker tests”) of an instrumented surrogate PWR fuel assembly. The purpose of this set of tests was to measure strains and accelerations on Zircaloy-4 fuel rods when the PWR assembly was subjected to rail and truck loadings simulating normal conditions of transport when affixed to a multi-axis shaker. This is the first set of tests of the assembly simulating rail normal conditions of transport.

Surrogate fuel assembly multi-axis shaker tests to simulate normal conditions of rail and truck transport

DOE Office of Scientific and Technical Information (OSTI.GOV)

McConnell, Paul E.; Koenig, Greg John; Uncapher, William Leonard

2016-05-12

This report describes the third set of tests (the “DCL a shaker tests”) of an instrumented surrogate PWR fuel assembly. The purpose of this set of tests was to measure strains and accelerations on Zircaloy-4 fuel rods when the PWR assembly was subjected to rail and truck loadings simulating normal conditions of transport when affixed to a multi-axis shaker. This is the first set of tests of the assembly simulating rail normal conditions of transport.

Committee Meeting of Assembly Education Committee "To Receive Testimony from the Commissioner of Education, Mary Lee Fitzgerald, Department Staff, and Others Concerning the Department's Skills Testing Program, Including the Early Warning Test and High School Proficiency Test, Pursuant to Assembly Resolution No. 113."

ERIC Educational Resources Information Center

New Jersey State Office of Legislative Services, Trenton. Assembly Education Committee.

The Assembly Education Committee of the New Jersey Office of Legislative Services held a hearing pursuant to Assembly Resolution 113, a proposal directing the Committee to investigate the skills testing program developed and administered to New Jersey children by the State Department of Education. The Committee was interested in the eighth-grade…

A System for the Automatic Assembly of Test Questions Using a No-SQL Database

ERIC Educational Resources Information Center

Shin, Sanggyu; Hashimoto, Hiroshi

2014-01-01

We describe a system that automatically assembles test questions from a set of examples. Our system can create test questions appropriate for each user's level at low cost. In particular, when a user review their lesson, our system provides new test questions which are assembled based on their previous test results and past mistakes, rather than a…

Micro electro-mechanical heater

DOEpatents

Oh, Yunje; Asif, Syed Amanulla Syed; Cyrankowski, Edward; Warren, Oden Lee

2016-04-19

A sub-micron scale property testing apparatus including a test subject holder and heating assembly. The assembly includes a holder base configured to couple with a sub-micron mechanical testing instrument and electro-mechanical transducer assembly. The assembly further includes a test subject stage coupled with the holder base. The test subject stage is thermally isolated from the holder base. The test subject stage includes a stage subject surface configured to receive a test subject, and a stage plate bracing the stage subject surface. The stage plate is under the stage subject surface. The test subject stage further includes a heating element adjacent to the stage subject surface, the heating element is configured to generate heat at the stage subject surface.

Micro electro-mechanical heater

DOEpatents

Oh, Yunje; Asif, Syed Amanulla Syed; Cyrankowski, Edward; Warren, Oden Lee

2017-09-12

A sub-micron scale property testing apparatus including a test subject holder and heating assembly. The assembly includes a holder base configured to couple with a sub-micron mechanical testing instrument and electro-mechanical transducer assembly. The assembly further includes a test subject stage coupled with the holder base. The test subject stage is thermally isolated from the holder base. The test subject stage includes a stage subject surface configured to receive a test subject, and a stage plate bracing the stage subject surface. The stage plate is under the stage subject surface. The test subject stage further includes a heating element adjacent to the stage subject surface, the heating element is configured to generate heat at the stage subject surface.

Fabrication of capsule assemblies, phase 3

NASA Technical Reports Server (NTRS)

Keeton, A. R.; Stemann, L. G.

1973-01-01

Thirteen capsule assemblies were fabricated for evaluation of fuel pin design concepts for a fast spectrum lithium cooled compact space power reactor. These instrumented assemblies were designed for real time test of prototype fuel pins. Uranium mononitride fuel pins were encased in AISI 304L stainless steel capsules. Fabrication procedures were fully qualified by process development and assembly qualification tests. Instrumentation reliability was achieved utilizing specially processed and closely controlled thermocouple hot zone fabrication and by thermal screening tests. Overall capsule reliability was achieved with an all electron beam welded assembly.

Process for Testing Compaction of a Swaged Heater for an Anode Sub-Assembly of a Hollow Cathode Assembly

NASA Technical Reports Server (NTRS)

Patterson, Michael J. (Inventor); Verhey, Timothy R. R. (Inventor); Soulas, George C. (Inventor)

2003-01-01

A process for testing compaction of a swaged heater for an anode sub-assembly of a Hollow Cathode Assembly (HCA), in which a test sample is cleaned, its mass measured before and after immersion in kerosene for 24 hours, and a compaction percentage calculated. A swaged heater is rejected if the compaction percentage exceeds 84%, plus or minus 4%.

77 FR 75908 - Airworthiness Directives; Gulfstream Aerospace Corporation

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-26

.... (d) Subject Joint Aircraft System Component (JASC)/Air Transport Association (ATA) of America Code... of the fuel boost pump and over-heat damage found on the internal components and external housing. This proposed AD would require doing an inspection to determine if fuel boost pumps having a certain...

Rural health care support mechanism. Final rule; petition for reconsideration.

PubMed

2008-04-10

In this document, the Commission grants American Telemedicine Association's (ATA) Petition for Reconsideration in part and extends for three years the Commission's prior determination to grandfather those health care providers who were eligible under the Commission's definition of "rural" prior to the Second Report and Order.

Phase III (final) evaluation report : national evaluation of the FY01 earmark, area transportation authority of North Central Pennsylvania--regional GIS/ITS initiative.

DOT National Transportation Integrated Search

2009-08-31

This report presents the results of the United States Department of Transportation evaluation of a federally funded earmark project implemented by the Area Transportation Authority of North Central Pennsylvania (ATA). The project implemented a suite ...

76 FR 49388 - Proposed Establishment of Class E Airspace; Tatitlek, AK

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-10

... approach procedure at the Tatitlek Airport has made this action necessary to enhance safety and management... 26, 2011. ADDRESSES: Send comments on the proposal to the Docket Management Facility, U.S. Department... Federal Aviation Administration, Office of Air Traffic Airspace Management, ATA-400, 800 Independence...

46 CFR 197.204 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Institute “Code for Pressure Piping, Power Piping.” ASME Code means the American Society of Mechanical Engineers “Boiler and Pressure Vessel Code.” ASME PVHO-1 means the ANSI/ASME standard “Safety Standard for Pressure Vessels for Human Occupancy.” ATA means a measure of pressure expressed in terms of atmosphere...

46 CFR 197.204 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Institute “Code for Pressure Piping, Power Piping.” ASME Code means the American Society of Mechanical Engineers “Boiler and Pressure Vessel Code.” ASME PVHO-1 means the ANSI/ASME standard “Safety Standard for Pressure Vessels for Human Occupancy.” ATA means a measure of pressure expressed in terms of atmosphere...

46 CFR 197.204 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Institute “Code for Pressure Piping, Power Piping.” ASME Code means the American Society of Mechanical Engineers “Boiler and Pressure Vessel Code.” ASME PVHO-1 means the ANSI/ASME standard “Safety Standard for Pressure Vessels for Human Occupancy.” ATA means a measure of pressure expressed in terms of atmosphere...

46 CFR 197.204 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Institute “Code for Pressure Piping, Power Piping.” ASME Code means the American Society of Mechanical Engineers “Boiler and Pressure Vessel Code.” ASME PVHO-1 means the ANSI/ASME standard “Safety Standard for Pressure Vessels for Human Occupancy.” ATA means a measure of pressure expressed in terms of atmosphere...

75 FR 26062 - Representation Election Procedure

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-11

... as follows. A. Motions for Disqualification Following the close of the comment period under the NPRM... 15, 2010, Right to Work also filed a motion requesting the disqualification of Members Hoglander and... Airlines, and US Airways did not join in this motion. ATA and Right to Work each contend \\3\\ that ``[p...

Educational activities for the diffusion of scientific culture

NASA Astrophysics Data System (ADS)

Ferlet, Roger

2015-08-01

Considering there is a divorce between science and culture, we suggest activities such as trails of mathematical/astronomical knowledge and vision of scientific teaching and education, that are aiming ata global, citizen dialogue, at reviving a truly human culture integrating science, and at answering all kinds of obscurantism/fundamentalism.

Translation and Interpreting Support for Army R&D Activities.

DTIC Science & Technology

1986-04-30

mean "radio-thermal" translate into English as "infrared." •" 24/ American Translators’ Association, 109 Croton Avenue, Ossining , New York 10562. 68...Translator and Interpreter Training Prepared on Behalf of the ATA, Ossining , NY, August 1983 Gale Research Company, 1985-85 Encyclopedia of Information

Uncertainties in the Item Parameter Estimates and Robust Automated Test Assembly

ERIC Educational Resources Information Center

Veldkamp, Bernard P.; Matteucci, Mariagiulia; de Jong, Martijn G.

2013-01-01

Item response theory parameters have to be estimated, and because of the estimation process, they do have uncertainty in them. In most large-scale testing programs, the parameters are stored in item banks, and automated test assembly algorithms are applied to assemble operational test forms. These algorithms treat item parameters as fixed values,…

FUEL ASSEMBLY SHAKER TEST SIMULATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klymyshyn, Nicholas A.; Sanborn, Scott E.; Adkins, Harold E.

This report describes the modeling of a PWR fuel assembly under dynamic shock loading in support of the Sandia National Laboratories (SNL) shaker test campaign. The focus of the test campaign is on evaluating the response of used fuel to shock and vibration loads that a can occur during highway transport. Modeling began in 2012 using an LS-DYNA fuel assembly model that was first created for modeling impact scenarios. SNL’s proposed test scenario was simulated through analysis and the calculated results helped guide the instrumentation and other aspects of the testing. During FY 2013, the fuel assembly model was refinedmore » to better represent the test surrogate. Analysis of the proposed loads suggested the frequency band needed to be lowered to attempt to excite the lower natural frequencies of the fuel assembly. Despite SNL’s expansion of lower frequency components in their five shock realizations, pretest predictions suggested a very mild dynamic response to the test loading. After testing was completed, one specific shock case was modeled, using recorded accelerometer data to excite the model. Direct comparison of predicted strain in the cladding was made to the recorded strain gauge data. The magnitude of both sets of strain (calculated and recorded) are very low, compared to the expected yield strength of the Zircaloy-4 material. The model was accurate enough to predict that no yielding of the cladding was expected, but its precision at predicting micro strains is questionable. The SNL test data offers some opportunity for validation of the finite element model, but the specific loading conditions of the testing only excite the fuel assembly to respond in a limited manner. For example, the test accelerations were not strong enough to substantially drive the fuel assembly out of contact with the basket. Under this test scenario, the fuel assembly model does a reasonable job of approximating actual fuel assembly response, a claim that can be verified through direct comparison of model results to recorded test results. This does not offer validation for the fuel assembly model in all conceivable cases, such as high kinetic energy shock cases where the fuel assembly might lift off the basket floor to strike to basket ceiling. This type of nonlinear behavior was not witnessed in testing, so the model does not have test data to be validated against.a basis for validation in cases that substantially alter the fuel assembly response range. This leads to a gap in knowledge that is identified through this modeling study. The SNL shaker testing loaded a surrogate fuel assembly with a certain set of artificially-generated time histories. One thing all the shock cases had in common was an elimination of low frequency components, which reduces the rigid body dynamic response of the system. It is not known if the SNL test cases effectively bound all highway transportation scenarios, or if significantly greater rigid body motion than was tested is credible. This knowledge gap could be filled through modeling the vehicle dynamics of a used fuel conveyance, or by collecting acceleration time history data from an actual conveyance under highway conditions.« less

Development of a Cryogenic Thermal Distortion Measurement Facility for Testing the James Webb Space Telescope Instrument Support Integration Module 2-D Test Assemblies

NASA Technical Reports Server (NTRS)

Miller, Franklin; Bagdanove, paul; Blake, Peter; Canavan, Ed; Cofie, Emmanuel; Crane, J. Allen; Dominquez, Kareny; Hagopian, John; Johnston, John; Madison, Tim;

Probe tip heating assembly

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schmitz, Roger William; Oh, Yunje

A heating assembly configured for use in mechanical testing at a scale of microns or less. The heating assembly includes a probe tip assembly configured for coupling with a transducer of the mechanical testing system. The probe tip assembly includes a probe tip heater system having a heating element, a probe tip coupled with the probe tip heater system, and a heater socket assembly. The heater socket assembly, in one example, includes a yoke and a heater interface that form a socket within the heater socket assembly. The probe tip heater system, coupled with the probe tip, is slidably receivedmore » and clamped within the socket.« less

42 CFR 84.20 - Examination, inspection, and testing of complete respirator assemblies; fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... assemblies; fees. Except as provided in § 84.22, the following fees shall be charged by the Institute for the examination, inspection and testing of complete respirator assemblies: Self-contained breathing apparatus... respirator assemblies; fees. 84.20 Section 84.20 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH...

42 CFR 84.20 - Examination, inspection, and testing of complete respirator assemblies; fees.

Code of Federal Regulations, 2011 CFR

2011-10-01

... assemblies; fees. Except as provided in § 84.22, the following fees shall be charged by the Institute for the examination, inspection and testing of complete respirator assemblies: Self-contained breathing apparatus... respirator assemblies; fees. 84.20 Section 84.20 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH...

42 CFR 84.20 - Examination, inspection, and testing of complete respirator assemblies; fees.

Code of Federal Regulations, 2014 CFR

2014-10-01

... respirator assemblies; fees. 84.20 Section 84.20 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH... assemblies; fees. Except as provided in § 84.22, the following fees shall be charged by the Institute for the examination, inspection and testing of complete respirator assemblies: Self-contained breathing apparatus...

42 CFR 84.20 - Examination, inspection, and testing of complete respirator assemblies; fees.

Code of Federal Regulations, 2012 CFR

2012-10-01

... respirator assemblies; fees. 84.20 Section 84.20 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH... assemblies; fees. Except as provided in § 84.22, the following fees shall be charged by the Institute for the examination, inspection and testing of complete respirator assemblies: Self-contained breathing apparatus...

42 CFR 84.20 - Examination, inspection, and testing of complete respirator assemblies; fees.

Code of Federal Regulations, 2013 CFR

2013-10-01

... respirator assemblies; fees. 84.20 Section 84.20 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH... assemblies; fees. Except as provided in § 84.22, the following fees shall be charged by the Institute for the examination, inspection and testing of complete respirator assemblies: Self-contained breathing apparatus...

Internally damped, self-arresting vertical drop-weight impact test apparatus

NASA Technical Reports Server (NTRS)

Ambur, Damodar R. (Inventor); Prasad, Chunchu B. (Inventor); Waters, Jr., William A. (Inventor); Stockum, Robert W. (Inventor); Walter, Manfred A. (Inventor)

1996-01-01

A vertical dropped-weight impact test machine has a dropped-weight barrel vertically supported on upper and lower support brackets. The dropped-weight barrel is chambered to receive a dropped-weight assembly having a latch pin at its upper end, a damping unit in the middle, and a tup at its lower end. The tup is adapted for gathering data during impact testing. The latch pin releasably engages a latch pin coupling assembly. The latch pin coupling assembly is attached to a winch via a halyard for raising and lowering the dropped-weight assembly. The lower end of the dropped-weight barrel is provided with a bounce-back arresting mechanism which is activated by the descending passage of the dropped-weight assembly. After striking the specimen, the dropped-weight assembly rebounds vertically and is caught by the bounce-back arresting mechanism. The damping unit of the dropped-weight assembly serves to dissipate energy from the rebounding dropped-weight assembly and prevents the dropped-weight assembly from rebounding from the self-arresting mechanism.

Internally damped, self-arresting vertical drop-weight impact test apparatus

NASA Technical Reports Server (NTRS)

Ambur, Damodar R. (Inventor); Prasad, Chunchu B. (Inventor); Waters, Jr., William A. (Inventor); Stockum, Robert W. (Inventor); Water, Manfred A. (Inventor)

1995-01-01

A vertical dropped-weight impact test machine has a dropped-weight barrel vertically supported on upper and lower support brackets. The dropped-weight barrel is chambered to receive a dropped-weight assembly having a latch pin at its upper end, a damping unit in the middle, and a tup at its lower end. The tup is adapted for gathering data during impact testing. The latch pin releasably engages a latch pin coupling assembly. The latch pin coupling assembly is attached to a winch via a halyard for raising and lowering the dropped-weight assembly. The lower end of the dropped-weight barrel is provided with a bounce-back arresting mechanism which is activated by the descending passage of the dropped-weight assembly. After striking the specimen, the dropped-weight assembly rebounds vertically and is caught by the bounce-back arresting mechanism. The damping unit of the dropped-weight assembly serves to dissipate energy from the rebounding dropped-weight assembly and prevents the dropped-weight assembly from rebounding from the self-arresting mechanism.

Robotic space construction

NASA Technical Reports Server (NTRS)

Mixon, Randolph W.; Hankins, Walter W., III; Wise, Marion A.

1988-01-01

Research at Langley AFB concerning automated space assembly is reviewed, including a Space Shuttle experiment to test astronaut ability to assemble a repetitive truss structure, testing the use of teleoperated manipulators to construct the Assembly Concept for Construction of Erectable Space Structures I truss, and assessment of the basic characteristics of manipulator assembly operations. Other research topics include the simultaneous coordinated control of dual-arm manipulators and the automated assembly of candidate Space Station trusses. Consideration is given to the construction of an Automated Space Assembly Laboratory to study and develop the algorithms, procedures, special purpose hardware, and processes needed for automated truss assembly.

iLIDS Simulations and Videos for Docking TIM

NASA Technical Reports Server (NTRS)

Lewis, James L.

2010-01-01

The video shows various aspects of the International Low Impact Docking System, including team members, some production, configuration, mated androgynous iLIDS, SCS Lockdown system, thermal analysis, electrical engineering aspects, the iLIDS control box and emulator, radiation testing at BNL, component environmental testing, component vibration testing, 3G processor board delivery system, GTA vibe test, EMA testbed, hook and hook disassembly, flex shaftdrive assembly, GSE cradle MISSE-6 Columbus, MISSE 6 and 7 seal experiments, actuated full scale seal test rig, LIDS on Hubble, dynamics test prep, EDU 54 mass emulation and SCS, load ring characterization, 6DOF proof test, SCS at 6DOF, machining EEMS and inner ring assembly, APAS assembly, inner ring fitting, rotation stand assembly, EEMS mating, and EEMS proof of concept demonstration.

Cryogenic Optical Performance of a Light-weight Mirror Assembly for Future Space Astronomical Telescopes: Optical Test Results and Thermal Optical Model

NASA Technical Reports Server (NTRS)

Eng, Ron; Arnold, William; Baker, Markus A.; Bevan, Ryan M.; Carpenter, James R.; Effinger, Michael R.; Gaddy, Darrell E.; Goode, Brian K.; Kegley, Jeffrey R.; Hogue, William D.;

Characterization of the Twelve Channel 100/140 Micron Optical Fiber, Ribbon Cable and MTP Array Connector Assembly for Space Flight Environments

NASA Technical Reports Server (NTRS)

Ott, Melanie N.; Macmurphy, Shawn; Friedberg, Patricia; Day, John H. (Technical Monitor)

2002-01-01

Presented here is the second set of testing conducted by the Technology Validation Laboratory for Photonics at NASA Goddard Space Flight Center on the 12 optical fiber ribbon cable with MTP array connector for space flight environments. In the first set of testing the commercial 62.5/125 cable assembly was characterized using space flight parameters. The testing showed that the cable assembly would survive a typical space flight mission with the exception of a vacuum environment. Two enhancements were conducted to the existing technology to better suit the vacuum environment as well as the existing optoelectronics and increase the reliability of the assembly during vibration. The MTP assembly characterized here has a 100/140 optical commercial fiber and non outgassing connector and cable components. The characterization for this enhanced fiber optic cable assembly involved vibration, thermal and radiation testing. The data and results of this characterization study are presented which include optical in-situ testing.

Effect of pronase on high-incidence blood group antigens and the prevalence of antibodies to pronase-treated erythrocytes.

PubMed

Reid, M E; Greeen, C A; Hoffer, J; Øyen, R

1996-01-01

Pronase is a useful and relatively nonspecific protease that cleaves many red blood cell (RBC) membrane proteins that carry blood group antigens. Unexpected findings in tests using pronase-treated RBCs during the investigation of a patient's blood sample led us to test which high-incidence blood group antigens were sensitive and which were resistant to pronase treatment, and to determine the prevalence of antipronase in the serum of blood donors. Our results show that antigens in the Cromer and Lutheran blood group systems and the JMH antigen were sensitive to pronase treatment of RBCs. Antigens in the Dombrock blood group system and Sc1 were either sensitive to or markedly weakened by pronase treatment of RBCs. The following high-incidence antigens were resistant to treatment of RBCs with pronase: AnWj, Ata, Coa, Co3, Dib, EnaFR, Era, Fy3, Jk3, Jra, k, Kpb, Jsb, K14, Lan, Oka, Rh17, U, Vel, and Wrb. Over half of the serum samples from normal blood donors contained antibodies to pronase-treated RBCs. When testing human serum against pronase-treated RBCs, it is essential either to use an autocontrol or to perform the testing with an eluate.

76 FR 19468 - Amended Certification Regarding Eligibility To Apply for Worker Adjustment Assistance

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-07

... Known As ATW Automation, Inc., Livonia Michigan TA-W-72,075A Assembly & Test Worldwide, Inc., Currently... Saginaw, Michigan locations of Assembly & Test Worldwide, Inc., are currently known as ATW Automation, Inc... Automation, Inc., Livonia, Michigan (TA-W-72,075); Assembly & Test Worldwide, Inc., currently known as ATW...

Using Set Covering with Item Sampling to Analyze the Infeasibility of Linear Programming Test Assembly Models

ERIC Educational Resources Information Center

Huitzing, Hiddo A.

2004-01-01

This article shows how set covering with item sampling (SCIS) methods can be used in the analysis and preanalysis of linear programming models for test assembly (LPTA). LPTA models can construct tests, fulfilling a set of constraints set by the test assembler. Sometimes, no solution to the LPTA model exists. The model is then said to be…

77 FR 23166 - Airworthiness Directives; The Boeing Company Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-18

... Aircraft System Component (JASC)/Air Transport Association (ATA) of America Code 28, Fuel. (e) Unsafe...-30F, MD-11, and MD-11F airplanes. This proposed AD was prompted by fuel system reviews conducted by... for fuel tank systems. As a result of those findings, we issued a regulation titled ``Transport...

EPA'S ENVIRONMENTAL MONITORING AND ASSESSMENT PROGRAM: AVAILABILITY OF BROAD-SCALE ENVIRONMENTAL DATA AND OPPORTUNITIES FOR USE IN ENVIRONMENTAL MODELING APPLICATIONS

EPA Science Inventory

The Environmental Monitoring and Assessment Program (EMAP) has collected a suite of environmental data over a four year period from estuarine system in the mid-Atlantic and Gulf of Mexico. ata are currently available for secondary users including environmental modelers. he data w...

An Automated Cloud Observation System (ACOS).

DTIC Science & Technology

1980-12-17

IQ 4. TITLE (and SubliIII.J 5- TYPE OF REPORT & PERIOD COVERED AN.JUTOXMATrD A LOUD OBSERVATION Scientific . Interim. SYSTEM (ALLIS) 6 PERFORMING ORG...p oci -dIi IV ( ( )S). . hhe 6 lists the percentage of agreement realizied by -:~ tc thc fiftt en metthods (I’ p touping ceilomieter t’ ata (see Ta

GRAS notice 733 for Purified steviol glycosides part 2

Center for Food Safety and Applied Nutrition (CFSAN)

... d()..to. +.'LSl. ct ~ttJ!~~: D : \\ CH . EM32\\ l\\~ATA\\2 J l 6 ~ 09-~~;:1CG002;.o , 'r'\\CVV'I naa~~ .. L' t~ tw~ ~i. i..i./J(ti-. • "'t. c:i.tta.. P.«f pe4t. (J.~" ...

Cheaters: A Case Study of Plagiarism in Composition Classrooms

ERIC Educational Resources Information Center

Yadgir, Sheri A.

2013-01-01

This study sought to find a better understanding of plagiarism in the university writing classroom; specifically, institutional and departmental honor codes and policies were looked at--as was the tendency of individual instructors to follow those policies versus creating their own. The narrow purpose of the study was to investigate plagiarism…

Beyond the Myth of Confrontation: A Comparative Study of African and African-American Female Protagonists.

ERIC Educational Resources Information Center

Eko, Ebele

1986-01-01

Describes mother-daughter relations in four American and African literary works: Ama Ata Aidoo's "Anowa," Gloria Naylor's "Women of Brewster Place," Bessie Head's "Maru," and Paule Marshall's "Brown Girl Brownstones." Argues that the myth of Black mother-daughter confrontations camouflages deep-seated frustrations associated with racial and sexual…

76 FR 62661 - Airworthiness Directives; The Boeing Company Model 767-200 and -300 Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-11

...-766-5680; e-mail: [email protected] ; Internet: https://www.myboeingfleet.com . You may review...- 3356; phone: 425-917-6596; fax: 425-917-6590; e-mail: [email protected] . SUPPLEMENTARY INFORMATION... Transport Association (ATA) of America Code 25: Equipment and Furnishings. Unsafe Condition (e) This AD was...

JPRS Report, Proliferation Issues

DTIC Science & Technology

1992-06-25

control of INGTON POST saying: "Secretary of Defense Richard Nuclemon Minero Quimica Ltda. [Nuclebras Monazite and Cheney approved the Pentagon’s plan ... Planned [Alm a-Ata Radio] .................................................................................................. 26 Krasnoyarsk Search for...34 [Article by political staff: "Space plan defended"] He said the aim of the investigation was to determine the market opportunities, risks and

Comparing Student Perceptions of the Classroom Climate Created by U.S. American and International Teaching Assistants

ERIC Educational Resources Information Center

Meyer, Kevin R.; Mao, Yuping

2014-01-01

Previous studies have revealed that American undergraduate students complain about International Teaching Assistants' (ITAs) lack of English proficiency and rate ITAs lower than American Teaching Assistants (ATAs) on teaching evaluations. This study investigates student perceptions of classroom climate to discover how ITAs might overcome students'…

A New Paradigm of Primary Health Care in Kazakhstan

PubMed Central

Sharman, Almaz

2014-01-01

This paper discusses the need for change from Kazakhstan’s current disease-centric healthcare paradigm to a new primary health and wellness-centric health care paradigm, technology-driven and based on personal relationships within a social context. While many different papers have been published about the importance of prevention and primary health care, few have focused on healthcare transition in Kazakhstan or other countries in Central Asia. The WHO’s historic 1978 Alma-Ata Declaration signed in Kazakhstan promoted the centrality of primary care to the provision of effective, efficient, and equitable health services. Modern technologies such as the Internet, social media, and portable medical devices democratize medicine, providing great opportunities to rethink the Alma-Ata Declaration and reinvent primary health care on an entirely new platform that is knowledge-based and technology-assisted. The new paradigm suggested for the future development of health in Central Asian region emphasizes personal relationships and encourages sustainable solutions created by communities. This paper also introduces HealthCity, a new project in Kazakhstan aiming at introducing private, community-based and standardized primary healthcare that is driven by SmartHealth innovative technology. PMID:29755891

SETI Observations of Exoplanets with the Allen Telescope Array

NASA Astrophysics Data System (ADS)

Harp, G. R.; Richards, Jon; Tarter, Jill C.; Dreher, John; Jordan, Jane; Shostak, Seth; Smolek, Ken; Kilsdonk, Tom; Wilcox, Bethany R.; Wimberly, M. K. R.; Ross, John; Barott, W. C.; Ackermann, R. F.; Blair, Samantha

2016-12-01

We report radio SETI observations on a large number of known exoplanets and other nearby star systems using the Allen Telescope Array (ATA). Observations were made over about 19000 hr from 2009 May to 2015 December. This search focused on narrowband radio signals from a set totaling 9293 stars, including 2015 exoplanet stars and Kepler objects of interest and an additional 65 whose planets may be close to their habitable zones. The ATA observations were made using multiple synthesized beams and an anticoincidence filter to help identify terrestrial radio interference. Stars were observed over frequencies from 1 to 9 GHz in multiple bands that avoid strong terrestrial communication frequencies. Data were processed in near-real time for narrowband (0.7-100 Hz) continuous and pulsed signals with transmitter/receiver relative accelerations from -0.3 to 0.3 m s-2. A total of 1.9 × 108 unique signals requiring immediate follow-up were detected in observations covering more than 8 × 106 star-MHz. We detected no persistent signals from extraterrestrial technology exceeding our frequency-dependent sensitivity threshold of 180-310 × 10-26 W m-2.

Coaxial test fixture

DOEpatents

Praeg, Walter F.

1986-01-01

An assembly is provided for testing one or more contact material samples in a vacuum environment. The samples are positioned as an inner conductive cylinder assembly which is mounted for reciprocal vertical motion as well as deflection from a vertical axis. An outer conductive cylinder is coaxially positioned around the inner cylinder and test specimen to provide a vacuum enclosure therefor. A power source needed to drive test currents through the test specimens is connected to the bottom of each conductive cylinder, through two specially formed conductive plates. The plates are similar in form, having a plurality of equal resistance current paths connecting the power source to a central connecting ring. The connecting rings are secured to the bottom of the inner conductive assembly and the outer cylinder, respectively. A hydraulic actuator is also connected to the bottom of the inner conductor assembly to adjust the pressure applied to the test specimens during testing. The test assembly controls magnetic forces such that the current distribution through the test samples is symmetrical and that contact pressure is not reduced or otherwise disturbed.

Design, manufacture, and test of coolant pump-motor assembly for Brayton power conversion system

NASA Technical Reports Server (NTRS)

Gabacz, L. E.

1973-01-01

The design, development, fabrication, and testing of seven coolant circulating pump-motor assemblies are discussed. The pump-motor assembly is driven by the nominal 44.4-volt, 400-Hz, 3-phase output of a nominal 56-volt dc input inverter. The pump-motor assembly will be used to circulate Dow Corning 200 liquid coolant for use in a Brayton cycle space power system. The pump-motor assembly develops a nominal head of 70 psi at 3.7 gpm with an over-all efficiency of 26 percent. The design description, drawings, photographs, reliability results, and developmental and acceptance test results are included.

Advanced Stirling Radioisotope Generator Engineering Unit 2 (ASRG EU2) Final Assembly

NASA Technical Reports Server (NTRS)

Oriti, Salvatore M.

2015-01-01

NASA Glenn Research Center (GRC) has recently completed the assembly of a unique Stirling generator test article for laboratory experimentation. Under the Advanced Stirling Radioisotope Generator (ASRG) flight development contract, NASA GRC initiated a task to design and fabricate a flight-like generator for in-house testing. This test article was given the name ASRG Engineering Unit 2 (EU2) as it was effectively the second engineering unit to be built within the ASRG project. The intent of the test article was to duplicate Lockheed Martin's qualification unit ASRG design as much as possible to enable system-level tests not previously possible at GRC. After the cancellation of the ASRG flight development project, the decision was made to continue the EU2 build, and make use of a portion of the hardware from the flight development project. GRC and Lockheed Martin engineers collaborated to develop assembly procedures, leveraging the valuable knowledge gathered by Lockheed Martin during the ASRG development contract. The ASRG EU2 was then assembled per these procedures at GRC with Lockheed Martin engineers on site. The assembly was completed in August 2014. This paper details the components that were used for the assembly, and the assembly process itself.

16 CFR Figure 1 to Part 1633 - Test Assembly, Shown in Furniture Calorimeter (Configuration A)

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Test Assembly, Shown in Furniture Calorimeter (Configuration A) 1 Figure 1 to Part 1633 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION.... 1 Figure 1 to Part 1633—Test Assembly, Shown in Furniture Calorimeter (Configuration A) ER15MR06.000 ...

16 CFR Figure 1 to Part 1633 - Test Assembly, Shown in Furniture Calorimeter (Configuration A)

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Test Assembly, Shown in Furniture Calorimeter (Configuration A) 1 Figure 1 to Part 1633 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION.... 1 Figure 1 to Part 1633—Test Assembly, Shown in Furniture Calorimeter (Configuration A) ER15MR06.000 ...

16 CFR Figure 1 to Part 1633 - Test Assembly, Shown in Furniture Calorimeter (Configuration A)

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Test Assembly, Shown in Furniture Calorimeter (Configuration A) 1 Figure 1 to Part 1633 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION.... 1 Figure 1 to Part 1633—Test Assembly, Shown in Furniture Calorimeter (Configuration A) ER15MR06.000 ...

16 CFR Figure 1 to Part 1633 - Test Assembly, Shown in Furniture Calorimeter (Configuration A)

Code of Federal Regulations, 2012 CFR

2012-01-01

... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Test Assembly, Shown in Furniture Calorimeter (Configuration A) 1 Figure 1 to Part 1633 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION.... 1 Figure 1 to Part 1633—Test Assembly, Shown in Furniture Calorimeter (Configuration A) ER15MR06.000 ...

Heat release from wood wall assemblies using oxygen consumption method

Treesearch

Hao C. Tran; Robert E. White

1990-01-01

The concept of heat release rate is gaining acceptance in the evaluation of fire performance of materials and assemblies. However, this concept has not been incorporated into fire endurance testing such as the ASTM E-119 test method. Heat release rate of assemblies can be useful in determining the time at which the assemblies start to contribute to the controlled fire...

Mobile work station concept for assembly of large space structures (zero gravity simulation tests)

NASA Astrophysics Data System (ADS)

Heard, W. L., Jr.; Bush, H. G.; Wallsom, R. E.; Jensen, J. K.

1982-03-01

The concept presented is intended to enhance astronaut assembly of truss structure that is either too large or complex to fold for efficient Shuttle delivery to orbit. The potential of augmented astronaut assembly is illustrated by applying the result of the tests to a barebones assembly of a truss structure. If this structure were assembled from the same nestable struts that were used in the Mobile Work Station assembly tests, the spacecraft would be 55 meters in diameter and consist of about 500 struts. The struts could be packaged in less than 1/2% of the Shuttle cargo bay volume and would take up approximately 3% of the mass lift capability. They could be assembled in approximately four hours. This assembly concept for erectable structures is not only feasible, but could be used to significant economic advantage by permitting the superior packaging feature of erectable structures to be exploited and thereby reduce expensive Shuttle delivery flights.

Mobile work station concept for assembly of large space structures (zero gravity simulation tests)

NASA Technical Reports Server (NTRS)

Heard, W. L., Jr.; Bush, H. G.; Wallsom, R. E.; Jensen, J. K.

1982-01-01

The concept presented is intended to enhance astronaut assembly of truss structure that is either too large or complex to fold for efficient Shuttle delivery to orbit. The potential of augmented astronaut assembly is illustrated by applying the result of the tests to a barebones assembly of a truss structure. If this structure were assembled from the same nestable struts that were used in the Mobile Work Station assembly tests, the spacecraft would be 55 meters in diameter and consist of about 500 struts. The struts could be packaged in less than 1/2% of the Shuttle cargo bay volume and would take up approximately 3% of the mass lift capability. They could be assembled in approximately four hours. This assembly concept for erectable structures is not only feasible, but could be used to significant economic advantage by permitting the superior packaging feature of erectable structures to be exploited and thereby reduce expensive Shuttle delivery flights.

Interleukin 10 (IL10) proximal promoter polymorphisms beyond clinical response in classical Hodgkin lymphoma: Exploring the basis for the genetic control of the tumor microenvironment

PubMed Central

Minnicelli, Carolina; Segges, Priscilla; Stefanoff, Gustavo; Kristcevic, Flavia; Ezpeleta, Joaquin; Tapia, Elizabeth; Niedobitek, Gerald; Barros, Mário Henrique M.

2018-01-01

ABSTRACT Interleukin-10 (IL10) is an immune regulatory cytokine. Single nucleotide polymorphisms (SNPs) in IL10 promoter have been associated with prognosis in adult classical Hodgkin lymphoma (cHL). We analyzed IL10 SNPs −1082 and −592 in respect of therapy response, gene expression and tumor microenvironment (TME) composition in 98 pediatric patients with cHL. As confirmatory results, we found that −1082AA/AG; −592CC genotypes and ATA haplotype were associated with unfavourable prognosis: Progression-free survival (PFS) was shorter in −1082AA+AG (72.2%) than in GG patients (100%) (P = 0.024), and in −592AA (50%) and AC (74.2%) vs. CC patients (87.0%) (P = 0.009). In multivariate analysis, the −592CC genotype and the ATA haplotype retained prognostic impact (HR: 0.41, 95% CI 0.2–0.86; P = 0.018, and HR: 3.06 95% CI 1.03–9.12; P = 0.044, respectively). Our analysis further led to some new observations, namely: (1) Low IL10 mRNA expression was associated with −1082GG genotype (P = 0.014); (2) IL10 promoter polymorphisms influence TME composition;−1082GG/−592CC carriers showed low numbers of infiltrating cells expressing MAF transcription factor (20 vs. 78 and 49 vs. 108 cells/mm2, respectively; P< 0.05); while ATA haplotype (high expression) associated with high numbers of MAF+ cells (P = 0.005). Specifically, −1082GG patients exhibited low percentages of CD68+MAF+ (M2-like) intratumoral macrophages (15.04% vs. 47.26%, P = 0.017). Considering ours as an independent validation cohort, our results give support to the clinical importance of IL10 polymorphisms in the full spectrum of cHL, and advance the concept of genetic control of microenvironment composition as a basis for susceptibility and therapeutic response. PMID:29721365

Interleukin 10 (IL10) proximal promoter polymorphisms beyond clinical response in classical Hodgkin lymphoma: Exploring the basis for the genetic control of the tumor microenvironment.

PubMed

Vera-Lozada, Gabriela; Minnicelli, Carolina; Segges, Priscilla; Stefanoff, Gustavo; Kristcevic, Flavia; Ezpeleta, Joaquin; Tapia, Elizabeth; Niedobitek, Gerald; Barros, Mário Henrique M; Hassan, Rocio

2018-01-01

Interleukin-10 (IL10) is an immune regulatory cytokine. Single nucleotide polymorphisms (SNPs) in IL10 promoter have been associated with prognosis in adult classical Hodgkin lymphoma (cHL). We analyzed IL10 SNPs -1082 and -592 in respect of therapy response, gene expression and tumor microenvironment (TME) composition in 98 pediatric patients with cHL. As confirmatory results, we found that -1082AA/AG; -592CC genotypes and ATA haplotype were associated with unfavourable prognosis: Progression-free survival (PFS) was shorter in -1082AA+AG (72.2%) than in GG patients (100%) (P = 0.024), and in -592AA (50%) and AC (74.2%) vs. CC patients (87.0%) (P = 0.009). In multivariate analysis, the -592CC genotype and the ATA haplotype retained prognostic impact (HR: 0.41, 95% CI 0.2-0.86; P = 0.018, and HR: 3.06 95% CI 1.03-9.12; P = 0.044, respectively). Our analysis further led to some new observations, namely: (1) Low IL10 mRNA expression was associated with -1082GG genotype (P = 0.014); (2) IL10 promoter polymorphisms influence TME composition;-1082GG/-592CC carriers showed low numbers of infiltrating cells expressing MAF transcription factor (20 vs. 78 and 49 vs. 108 cells/mm 2 , respectively; P< 0.05); while ATA haplotype (high expression) associated with high numbers of MAF+ cells (P = 0.005). Specifically, -1082GG patients exhibited low percentages of CD68+MAF+ (M2-like) intratumoral macrophages (15.04% vs. 47.26%, P = 0.017). Considering ours as an independent validation cohort, our results give support to the clinical importance of IL10 polymorphisms in the full spectrum of cHL, and advance the concept of genetic control of microenvironment composition as a basis for susceptibility and therapeutic response.

Hyperbaric oxygen preconditioning protects against traumatic brain injury at high altitude.

PubMed

Hu, S L; Hu, R; Li, F; Liu, Z; Xia, Y Z; Cui, G Y; Feng, H

2008-01-01

Recent studies have shown that preconditioning with hyperbaric oxygen (HBO) can reduce ischemic and hemorrhagic brain injury. We investigated effects of HBO preconditioning on traumatic brain injury (TBI) at high altitude and examined the role of matrix metalloproteinase-9 (MMP-9) in such protection. Rats were randomly divided into 3 groups: HBO preconditioning group (HBOP; n = 13), high-altitude group (HA; n = 13), and high-altitude sham operation group (HASO; n = 13). All groups were subjected to head trauma by weight-drop device, except for HASO group. HBOP rats received 5 sessions of HBO preconditioning (2.5 ATA, 100% oxygen, 1 h daily) and then were kept in hypobaric chamber at 0.6 ATA (to simulate pressure at 4000m altitude) for 3 days before operation. HA rats received control pretreatment (1 ATA, room air, 1 h daily), then followed the same procedures as HBOP group. HASO rats were subjected to skull opening only without brain injury. Twenty-four hours after TBI, 7 rats from each group were examined for neurological function and brain water content; 6 rats from each group were killed for analysis by H&E staining and immunohistochemistry. Neurological outcome in HBOP group (0.71 +/- 0.49) was better than HA group (1.57 +/- 0.53; p < 0.05). Preconditioning with HBO significantly reduced percentage of brain water content (86.24 +/- 0.52 vs. 84.60 +/- 0.37; p < 0.01). Brain morphology and structure seen by light microscopy was diminished in HA group, while fewer pathological injuries occurred in HBOP group. Compared to HA group, pretreatment with HBO significantly reduced the number of MMP-9-positive cells (92.25 +/- 8.85 vs. 74.42 +/- 6.27; p < 0.01). HBO preconditioning attenuates TBI in rats at high altitude. Decline in MMP-9 expression may contribute to HBO preconditioning-induced protection of brain tissue against TBI.

Antithymocyte antibody-induced coagulopathy in renal transplant recipients.

PubMed

Siparsky, N F; Klein, R; Kushnir, L F; Gallichio, M H; Conti, D J

2013-05-01

Antithymocyte antibody (ATA) remains the most commonly used induction immunosuppressive agent in renal transplantation (RT). To date, few case reports of ATA-induced coagulopathy exist. We performed a single-center, retrospective analysis of renal transplant recipients (RTRs) who underwent RT followed by ATA therapy between 2007 and 2011. The protocol used for deceased donor and unrelated living donor recipient immunosuppression was Thymoglobulin (TMG), methylprednisolone, Cellcept, Prograf, and Rapamune. In related living donor recipients, Simulect (SIM) was substituted for TMG. The international normalized ratio (INR) was routinely checked on days 0 and 2, and thereafter at the discretion of the surgeon. RTRs were transfused packed red blood cells (PRBCs) or fresh frozen plasma (FFP) at the discretion of the surgeon. During the study period, 257 RTs were performed at our institution. The following 18 RTR were excluded: simultaneous kidney and pancreas transplant recipients (4), RTRs on warfarin at the time of admission (2), RTRs who received OKT3 (2), and RTRs with INR ≥ 1.2 at the time of admission (10). Of the remaining 239 RTR, 208 (87%) underwent TMG induction therapy; 31 RTR (13%) underwent SIM induction therapy. The mean INR peaked in both groups on day 4 but was higher in TMG recipients (TMG 1.35, SIM 1.20). FFP was transfused in 65 TMG (31%) and 3 SIM (10%) recipients (P = .01); PRBCs were transfused in 88 TMG (44%) and 6 SIM (19%) recipients (P = .02). No patients returned to the operating room for bleeding complications within 7 days of RT. Patient age, gender, ethnicity, and diabetes status were not statistically significant factors in the development of coagulopathy. TMG administration is associated with coagulopathy. Using an INR screening protocol and an aggressive transfusion protocol, bleeding complications associated with coagulopathy can be avoided in this higher-risk group. Copyright © 2013 Elsevier Inc. All rights reserved.

Prospective evaluation of the acute patient physiologic and laboratory evaluation score and an extended clinicopathological profile in dogs with systemic inflammatory response syndrome.

PubMed

Giunti, Massimo; Troia, Roberta; Bergamini, Paolo Famigli; Dondi, Francesco

2015-01-01

To investigate the prognostic value of the acute patient physiologic and laboratory evaluation (APPLE) score and relevant clinicopathological markers in dogs with systemic inflammatory response syndrome (SIRS). Prospective observational cohort study. Veterinary teaching hospital. Thirty-three dogs with SIRS admitted to the intensive care unit (ICU) were compared to 35 healthy control dogs. Dogs with SIRS were divided into septic (n = 20) and nonseptic (n = 13) etiologies and as survivors (alive to discharge, n = 22) and nonsurvivors (n = 11: died, n = 6, or humanely euthanized, n = 5). For all dogs, physiological and laboratory parameters were prospectively collected for the calculation of the APPLE fast score. No difference between septic and nonseptic SIRS dogs was detected for any parameter evaluated. Survivors had significantly higher total protein, albumin concentrations, antithrombin activity (ATA), and base excess (BE), as well as significantly lower lactate, urea, creatinine concentrations, urinary protein to creatinine ratio and APPLE fast score compared to nonsurvivors. Higher values of creatinine, lactate, anion gap, alanine transaminase (ALT), and APPLE fast score were significantly associated with an increased risk of death in SIRS dogs, while higher values of total protein, albumin, ATA, and BE were associated with a significantly reduced risk of mortality. When a multivariate binary logistic regression analysis was performed, the APPLE fast score was the only significant parameter retained. The determination of the APPLE fast score in clinical setting, as well as the measurement of APP, ATA, lactate, BE, anion gap, ALT, urinary proteins, and electrolytes may be beneficial for a better assessment of dogs with SIRS. Identified parameters were significantly related with the presence of SIRS and their evaluation should be considered for the assessment of disease severity, and guidance of the decision-making process in critically ill dogs. © Veterinary Emergency and Critical Care Society 2014.

14. VIEW TO WESTSOUTHWEST ACROSS CAR TEST TRACT SITE TO ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. VIEW TO WEST-SOUTHWEST ACROSS CAR TEST TRACT SITE TO NORTH END OF ASSEMBLY PLANT, SHOWING NORTH END ADDITIONS. - Ford Motor Company Long Beach Assembly Plant, Assembly Building, 700 Henry Ford Avenue, Long Beach, Los Angeles County, CA

A mobile work station concept for mechanically aided astronaut assembly of large space trusses

NASA Technical Reports Server (NTRS)

Heard, W. L., Jr.; Bush, H. G.; Wallson, R. E.; Jensen, J. K.

1983-01-01

This report presents results of a series of truss assembly tests conducted to evaluate a mobile work station concept intended to mechanically assist astronaut manual assembly of erectable space trusses. The tests involved assembly of a tetrahedral truss beam by a pair of test subjects with and without pressure (space) suits, both in Earth gravity and in simulated zero gravity (neutral buoyancy in water). The beam was assembled from 38 identical graphite-epoxy nestable struts, 5.4 m in length with aluminum quick-attachment structural joints. Struts and joints were designed to closely simulate flight hardware. The assembled beam was approximately 16.5 m long and 4.5 m on each of the four sides of its diamond-shaped cross section. The results show that average in-space assembly rates of approximately 38 seconds per strut can be expected for struts of comparable size. This result is virtually independent of the overall size of the structure being assembled. The mobile work station concept would improve astronaut efficiency for on-orbit manual assembly of truss structures, and also this assembly-line method is highly competitive with other construction methods being considered for large space structures.

Gasoline-Engine Assembler (engine & turbine) 806.781; Internal-Combustion-Engine-Assembler (engine & turbine) 806.781; Outboard-Motor Assembler (engine & turbine) 806.781--Technical Report on Development of USTES Aptitude Test Battery.

ERIC Educational Resources Information Center

Manpower Administration (DOL), Washington, DC. U.S. Training and Employment Service.

The United States Training and Employment Service General Aptitude Test Battery (GATB), first published in 1947, has been included in a continuing program of research to validate the tests against success in many different occupations. The GATB consists of 12 tests which measure nine aptitudes: General Learning Ability; Verbal Aptitude; Numerical…

The SLS Stages Intertank Structural Test Assembly (STA) arrives at MSFC.

NASA Image and Video Library

2018-03-06

The SLS Stages Intertank Structural Test Assembly (STA) is rolling off the NASA Pegasus Barge at the MSFC Dock enroute to the MSFC 4619 Load Test Annex test facility for qualification testing. STA emerges from Barge Pegasus.

Results of EVA/mobile transporter space station truss assembly tests

NASA Technical Reports Server (NTRS)

Watson, Judith J.; Heard, Walter L., Jr.; Bush, Harold G.; Lake, M. S.; Jensen, J. K.; Wallsom, R. E.; Phelps, J. E.

1988-01-01

Underwater neutral buoyance tests were conducted to evaluate the use of a Mobile Transporter concept in conjunction with EVA astronauts to construct the Space Station Freedom truss structure. A three-bay orthogonal tetrahedral truss configuration with a 15 foot square cross section was repeatedly assembled by a single pair of pressure suited test subjects working from the Mobile Transporter astronaut positioning devices (mobile foot restraints). The average unit assembly time (which included integrated installation of utility trays) was 27.6 s/strut, or 6 min/bay. The results of these tests indicate that EVA assembly of space station size structures can be significantly enhanced when using a Mobile Transporter equipped with astronaut positioning devices. Rapid assembly time can be expected and are dependent primarily on the rate of translation permissible for on-orbit operations. The concept used to demonstate integrated installation of utility trays requires minimal EVA handling and consequentially, as the results show, has little impact on overall assembly time.

Verification Test of Automated Robotic Assembly of Space Truss Structures

NASA Technical Reports Server (NTRS)

Rhodes, Marvin D.; Will, Ralph W.; Quach, Cuong C.

1995-01-01

A multidisciplinary program has been conducted at the Langley Research Center to develop operational procedures for supervised autonomous assembly of truss structures suitable for large-aperture antennas. The hardware and operations required to assemble a 102-member tetrahedral truss and attach 12 hexagonal panels were developed and evaluated. A brute-force automation approach was used to develop baseline assembly hardware and software techniques. However, as the system matured and operations were proven, upgrades were incorporated and assessed against the baseline test results. These upgrades included the use of distributed microprocessors to control dedicated end-effector operations, machine vision guidance for strut installation, and the use of an expert system-based executive-control program. This paper summarizes the developmental phases of the program, the results of several assembly tests, and a series of proposed enhancements. No problems that would preclude automated in-space assembly or truss structures have been encountered. The test system was developed at a breadboard level and continued development at an enhanced level is warranted.

Development and verification testing of automation and robotics for assembly of space structures

NASA Technical Reports Server (NTRS)

Rhodes, Marvin D.; Will, Ralph W.; Quach, Cuong C.

1993-01-01

A program was initiated within the past several years to develop operational procedures for automated assembly of truss structures suitable for large-aperture antennas. The assembly operations require the use of a robotic manipulator and are based on the principle of supervised autonomy to minimize crew resources. A hardware testbed was established to support development and evaluation testing. A brute-force automation approach was used to develop the baseline assembly hardware and software techniques. As the system matured and an operation was proven, upgrades were incorprated and assessed against the baseline test results. This paper summarizes the developmental phases of the program, the results of several assembly tests, the current status, and a series of proposed developments for additional hardware and software control capability. No problems that would preclude automated in-space assembly of truss structures have been encountered. The current system was developed at a breadboard level and continued development at an enhanced level is warranted.

The advanced receiver 2: Telemetry test results in CTA 21

NASA Technical Reports Server (NTRS)

Hinedi, S.; Bevan, R.; Marina, M.

1991-01-01

Telemetry tests with the Advanced Receiver II (ARX II) in Compatibility Test Area 21 are described. The ARX II was operated in parallel with a Block-III Receiver/baseband processor assembly combination (BLK-III/BPA) and a Block III Receiver/subcarrier demodulation assembly/symbol synchronization assembly combination (BLK-III/SDA/SSA). The telemetry simulator assembly provided the test signal for all three configurations, and the symbol signal to noise ratio as well as the symbol error rates were measured and compared. Furthermore, bit error rates were also measured by the system performance test computer for all three systems. Results indicate that the ARX-II telemetry performance is comparable and sometimes superior to the BLK-III/BPA and BLK-III/SDA/SSA combinations.

The NIRspec assembly integration and test status

NASA Astrophysics Data System (ADS)

Wettemann, Thomas; Ehrenwinkler, Ralf; Johnson, Thomas E.; Maschmann, Marc; Mosner, Peter; te Plate, Maurice; Rödel, Andreas

2017-11-01

The Near-Infrared Spectrograph (NIRSpec) is one of the four instruments on the James Webb Space Telescope (JWST) scheduled for launch in 2018. NIRSpec has been manufactured and tested by an European industrial consortium led by Airbus Defence and Space and delivered to the European Space Agency (ESA) and NASA in September 2013. Since then it has successfully been integrated into the JWST Integrated Science Instrument Module (ISIM) and is currently in ISIM Cryo-Vacuum Test#2. Since however two of its most important assemblies, the Focal Plane Assembly (FPA) and the Micro-Shutter Assembly (MSA) need to be replaced by new units we will present the status of the instrument, the status of its new flight assemblies in manufacturing and testing and give an outlook on the planned exchange activities and the following instrument re-verification.

The SLS Stages Intertank Structural Test Assembly (STA) arrives at MSFC

NASA Image and Video Library

2018-03-08

The SLS Stages Intertank Structural Test Assembly (STA) is rolling off the NASA Pegasus Barge at the MSFC Dock enroute to the MSFC 4619 Load Test Annex test facility for qualification testing via MSFC West Test Area. STA approaches Test Stand 4693, SLS LH2 test Stand, on way to Bldg. 4619

Performance Assessment of State Senior High School Teachers Aged 56 Years and Above

ERIC Educational Resources Information Center

Yusrizal; Harun, Cut Zahri; Husen; Iqbal, Muhammad

2018-01-01

This research aimed at determining the level of performance of state senior high school (Sekolah Menengah Atas Negeri abbreviated as SMAN) teachers aged 56 years and older. The research population was all SMAN teachers aged 56 years and older in Banda Aceh Municipality, Districts of Aceh Besar, Pidie and Pidie Jaya. Performance assessment…

77 FR 51542 - Medicare Program; Solicitation of Two Nominations to the Advisory Panel on Hospital Outpatient...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-24

... effective through November 15, 2013. DATES: Submission of Nominations: We will consider nominations if they... (local) for additional information. News Media: Representatives should contact the CMS Press Office at...)(A) of the Social Security Act (the Act), and section 222 of the Public Health Service Act (PHS Act...

Magnetic Resonance Arterial Spin Tagging for Noninvasive Pharmacokinetic Analysis of Breast Cancer

DTIC Science & Technology

1998-10-01

TIbr () - TIbr (j) and 1 In (Sreg - Sno (i)) - In (Sreg - Snon(J)) (1.9) Ti. Tlb, Wi - Tlbr W) where Sreg = the average steady-state signal intensity at...a pixel under the Regular Condition, Tlbr (i) = the ith effective inversion time (TI) (used for the ith image), Ssel(i) = the steady-state signal

75 FR 74616 - Airworthiness Directives; The Boeing Company Model 737-600, -700, -700C, -800, and -900 Series...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-01

... Fuel System Airworthiness Limitations, the requirements of Appendix H.1(a) of the Federal Aviation... Additional Service Information The ATA, on behalf of its member AirTran Airways, requested that we approve... comment, AirTran Airways stated that the information notices clarify and provide corrections to Boeing...

U.S. Army Hybrid Propulsion System R&D Overview ATA/Technology & Maintenance Council 2011 Fall Meeting, Hybrid Powertrain Task Force Session

DTIC Science & Technology

2011-09-19

Integration – Non-Thermal Plasma JP8 reformer & SOFC system – Lithium-Iron Phosphate Battery Technology – Lithium Ion Battery & energy storage systems...regeneration and includes a lithium ion battery energy storage – Export power capabilities meeting mission requirements (5-50 kilowatt [kW]) – Air

50 CFR 23.50 - What are the requirements for a sample collection covered by an ATA carnet?

Code of Federal Regulations, 2010 CFR

2010-10-01

... Appendix-I species bred in captivity or artificially propagated for commercial purposes, that will: (1..., BARTER, EXPORTATION, AND IMPORTATION OF WILDLIFE AND PLANTS (CONTINUED) CONVENTION ON INTERNATIONAL TRADE... plants in part 24 of this subchapter and 7 CFR parts 319, 352, and 355. (d) U.S. application form...

50 CFR 23.50 - What are the requirements for a sample collection covered by an ATA carnet?

Code of Federal Regulations, 2013 CFR

2013-10-01

... Appendix-I species bred in captivity or artificially propagated for commercial purposes, that will: (1..., BARTER, EXPORTATION, AND IMPORTATION OF WILDLIFE AND PLANTS (CONTINUED) CONVENTION ON INTERNATIONAL TRADE... plants in part 24 of this subchapter and 7 CFR parts 319, 352, and 355. (d) U.S. application form...

50 CFR 23.50 - What are the requirements for a sample collection covered by an ATA carnet?

Code of Federal Regulations, 2014 CFR

2014-10-01

... Appendix-I species bred in captivity or artificially propagated for commercial purposes, that will: (1..., BARTER, EXPORTATION, AND IMPORTATION OF WILDLIFE AND PLANTS (CONTINUED) CONVENTION ON INTERNATIONAL TRADE... plants in part 24 of this subchapter and 7 CFR parts 319, 352, and 355. (d) U.S. application form...

50 CFR 23.50 - What are the requirements for a sample collection covered by an ATA carnet?

Code of Federal Regulations, 2012 CFR

2012-10-01

... Appendix-I species bred in captivity or artificially propagated for commercial purposes, that will: (1..., BARTER, EXPORTATION, AND IMPORTATION OF WILDLIFE AND PLANTS (CONTINUED) CONVENTION ON INTERNATIONAL TRADE... plants in part 24 of this subchapter and 7 CFR parts 319, 352, and 355. (d) U.S. application form...

50 CFR 23.50 - What are the requirements for a sample collection covered by an ATA carnet?

Code of Federal Regulations, 2011 CFR

2011-10-01

... Appendix-I species bred in captivity or artificially propagated for commercial purposes, that will: (1..., BARTER, EXPORTATION, AND IMPORTATION OF WILDLIFE AND PLANTS (CONTINUED) CONVENTION ON INTERNATIONAL TRADE... plants in part 24 of this subchapter and 7 CFR parts 319, 352, and 355. (d) U.S. application form...

Aircraft Command in Emergency Situations (ACES). Phase 1. Concept. Development

DTIC Science & Technology

1991-04-01

tine-consuming, and if the left pack is malfunctioning, can allow large quantities of smoke to enter the passenger cabin, creating high levels of...airport, thus providing the crew additional time to evc’,ataIe th airplanc . ’li maved in landing the aircraft safely results from: a0 I)ctectioi n (f

Predicting Educational Outcomes and Psychological Well-Being in Adolescents Using Time Attitude Profiles

ERIC Educational Resources Information Center

Andretta, James R.; Worrell, Frank C.; Mello, Zena R.

2014-01-01

Using cluster analysis of Adolescent Time Attitude Scale (ATAS) scores in a sample of 300 adolescents ("M" age = 16 years; "SD" = 1.25; 60% male; 41% European American; 25.3% Asian American; 11% African American; 10.3% Latino), the authors identified five time attitude profiles based on positive and negative attitudes toward…

Combustion Stability of the Gas Generator Assembly from J-2X Engine E10001 and Powerpack Tests

NASA Technical Reports Server (NTRS)

Hulka, J. R.; Kenny, R. L.; Casiano, M. J.

2013-01-01

Testing of a powerpack configuration (turbomachinery and gas generator assembly) and the first complete engine system of the liquid oxygen/liquid hydrogen propellant J-2X rocket engine have been completed at the NASA Stennis Space Center. The combustion stability characteristics of the gas generator assemblies on these two systems are of interest for reporting since considerable effort was expended to eliminate combustion instability during early development of the gas generator assembly with workhorse hardware. Comparing the final workhorse gas generator assembly development test data to the powerpack and engine system test data provides an opportunity to investigate how the nearly identical configurations of gas generator assemblies operate with two very different propellant supply systems one the autonomous pressure-fed test configuration on the workhorse development test stand, the other the pump-fed configurations on the powerpack and engine systems. The development of the gas generator assembly and the elimination of the combustion instability on the pressure-fed workhorse test stand have been reported extensively in the two previous Liquid Propulsion Subcommittee meetings 1-7. The powerpack and engine system testing have been conducted from mid-2011 through 2012. All tests of the powerpack and engine system gas generator systems to date have been stable. However, measureable dynamic behavior, similar to that observed on the pressure-fed test stand and reported in Ref. [6] and attributed to an injection-coupled response, has appeared in both powerpack and engine system tests. As discussed in Ref. [6], these injection-coupled responses are influenced by the interaction of the combustion chamber with a branch pipe in the hot gas duct that supplies gaseous helium to pre-spin the turbine during the start transient. This paper presents the powerpack and engine system gas generator test data, compares these data to the development test data, and provides additional combustion stability analyses of the configurations.

EVA assembly of large space structure element

NASA Technical Reports Server (NTRS)

Bement, L. J.; Bush, H. G.; Heard, W. L., Jr.; Stokes, J. W., Jr.

1981-01-01

The results of a test program to assess the potential of manned extravehicular activity (EVA) assembly of erectable space trusses are described. Seventeen tests were conducted in which six "space-weight" columns were assembled into a regular tetrahedral cell by a team of two "space"-suited test subjects. This cell represents the fundamental "element" of a tetrahedral truss structure. The tests were conducted under simulated zero-gravity conditions. Both manual and simulated remote manipulator system modes were evaluated. Articulation limits of the pressure suit and zero gravity could be accommodated by work stations with foot restraints. The results of this study have confirmed that astronaut EVA assembly of large, erectable space structures is well within man's capabilities.

Thermodynamic performance testing of the orbiter flash evaporator system

NASA Technical Reports Server (NTRS)

Jaax, J. R.; Melgares, M. A.; Frahm, J. P.

1980-01-01

System level testing of the space shuttle orbiter's development flash evaporator system (FES) was performed in a thermal vacuum chamber capable of simulating ambient ascent, orbital, and entry temperature and pressure profiles. The test article included the evaporator assembly, high load and topping exhaust duct and nozzle assemblies, and feedwater supply assembly. Steady state and transient heat load, water pressure/temperature and ambient pressure/temperature profiles were imposed by especially designed supporting test hardware. Testing in 1978 verified evaporator and duct heater thermal design, determined FES performance boundaries, and assessed topping evaporator plume characteristics. Testing in 1979 combined the FES with the other systems in the orbiter active thermal control subsystem (ATCS). The FES met or exceeded all nominal and contingency performance requirements during operation with the integrated ATCS. During both tests stability problems were encountered during steady state operations which resulted in subsequent design changes to the water spray nozzle and valve plate assemblies.

Katome: de novo DNA assembler implemented in rust

NASA Astrophysics Data System (ADS)

Neumann, Łukasz; Nowak, Robert M.; Kuśmirek, Wiktor

2017-08-01

Katome is a new de novo sequence assembler written in the Rust programming language, designed with respect to future parallelization of the algorithms, run time and memory usage optimization. The application uses new algorithms for the correct assembly of repetitive sequences. Performance and quality tests were performed on various data, comparing the new application to `dnaasm', `ABySS' and `Velvet' genome assemblers. Quality tests indicate that the new assembler creates more contigs than well-established solutions, but the contigs have better quality with regard to mismatches per 100kbp and indels per 100kbp. Additionally, benchmarks indicate that the Rust-based implementation outperforms `dnaasm', `ABySS' and `Velvet' assemblers, written in C++, in terms of assembly time. Lower memory usage in comparison to `dnaasm' is observed.

Confirmatory Test of the Irritant Gas Disperser, Helicopter- or Vehicle- Mounted, M5

DTIC Science & Technology

1962-07-23

disperser consists of four major assemblies: An agent-container assembly, a pressure - group assembly, a support assembly, and a throat assembly. (1) The...base. (2) The pressure - group assembly consists of two steel high-pressure tanks, secured by steel band clamps to the pressure - group support assembly...aluminum alloy tubing welded together to provide a support for the agent-container assembly and the pressure - group assembly. Each of these separate

Adapter assembly prevents damage to tubing during high pressure tests

NASA Technical Reports Server (NTRS)

Stinett, L. L.

1965-01-01

Portable adapter assembly prevents damage to tubing and injury to personnel when pressurizing a system or during high pressure tests. The assembly is capable of withstanding high pressure. It is securely attached to the tubing stub end and may be removed without brazing, cutting or cleaning the tube.

Electromagnetic compatibility test report for the tethered satellite data acquisition and control assembly

NASA Astrophysics Data System (ADS)

Hoskins, Douglas; Snead, Robert

1988-05-01

This report details the results of an electromagnetic compatibility test on the SCI Systems Data Acquisition and Control Assembly (DACA). This assembly is an electronic processor which controls the central communication link from the Tethered Satellite System (TSS) to the Space Transportation System Orbiter Space Shuttle.

Analysis and Design of a Double-Divert Spiral Groove Seal

NASA Technical Reports Server (NTRS)

Zheng, Xiaoqing; Berard, Gerald

2007-01-01

This viewgraph presentation describes the design and analysis of a double spiral groove seal. The contents include: 1) Double Spiral Design Features; 2) Double Spiral Operational Features; 3) Mating Ring/Rotor Assembly; 4) Seal Ring Assembly; 5) Insert Segment Joints; 6) Rotor Assembly Completed Prototype Parts; 7) Seal Assembly Completed Prototype Parts; 8) Finite Element Analysis; 9) Computational Fluid Dynamics (CFD) Analysis; 10) Restrictive Orifice Design; 11) Orifice CFD Model; 12) Orifice Results; 13) Restrictive Orifice; 14) Seal Face Coning; 15) Permanent Magnet Analysis; 16) Magnetic Repulsive Force; 17) Magnetic Repulsive Test Results; 18) Spin Testing; and 19) Testing and Validation.

The AXAF technology mirror assembly program - An overview

NASA Technical Reports Server (NTRS)

Wyman, Charles L.; Dailey, Carroll C.; Reily, Cary; Weisskopf, Martin; Mckinnon, Phil

1986-01-01

The manufacture and testing of the Technology Mirror Assembly (TMA), a prototype Wolter I telescope scaled to the dimensions of the innermost element of the High-Resolution Mirror Assembly for the NASA Advanced X-ray Astrophysics Facility (AXAF), are reviewed. Consideration is given to the grinding, polishing, coating, and assembly of the zerodur TMA blanks, the TMA mount design, and the test procedures used at the MSFC X-ray Calibration Facility. Test results indicate FWHM resolution less than 0.5 arcsec, but with significant near-field scattering attributed to ripple; further long-lap polishing is suggested.

The SLS Stages Intertank Structural Test Assembly (STA) arrives at MSFC

NASA Image and Video Library

2018-03-06

The SLS Stages Intertank Structural Test Assembly (STA) is rolling off the NASA Pegasus Barge at the MSFC Dock enroute to the MSFC 4619 Load Test Annex test facility for qualification testing. STA hardware completely free of barge and flanked by tug boats.

A mobile transporter concept for EVA assembly of future spacecraft

NASA Technical Reports Server (NTRS)

Watson, Judith J.; Bush, Harold G.; Heard, Walter L., Jr.; Lake, Mark S.; Jensen, J. Kermit

1990-01-01

This paper details the ground test program for the NASA Langley Research Center Mobile Transporter concept. The Mobile Transporter would assist EVA astronauts in the assembly of the Space Station Freedom. 1-g and simulated O-g (neutral buoyancy) tests were conducted to evaluate the use of the Mobile Transporter. A three-bay (44 struts) orthogonal tetrahedral truss configuration with a 15-foot-square cross section was repeatedly assembled by a single pair of pressure suited test subjects working from the Mobile Transporter astronaut positioning devices. The average unit assembly time was 28 seconds/strut. The results of these tests indicate that the use of a Mobile Transporter for EVA assembly of Space Station size structure is viable and practical. Additionally, the Mobile Transporter could be used to construct other spacecraft such as the submillimeter astronomical laboratory, space crane, and interplanetary (i.e., Mars and lunar) spacecraft.

The effect of 17-4PH stainless steel on the lifetime of a Pennzane lubricated Microwave Limb Sounder Antenna Actuator Assembly ball screw for the AURA spacecraft

NASA Astrophysics Data System (ADS)

Jones, William R., Jr.; Jansen, Mark J.; Chen, Gun-Shing; Lam, Jonathan; Balzer, Mark; Lo, John; Anderson, Mark; Schepis, Joseph P.

2005-07-01

During ground based life testing of a Microwave Limb Sounder (MLS) Antenna Actuator Assembly (AAA) ball-screw assembly, lubricant darkening and loss were noted when approximately 10% of required lifetime was completed. The MLS-AAA ball screw and nut are made from 17-4 PH steel, the nut has 440C stainless steel balls, and the assembly is lubricated with a Pennzane formulation containing a three weight percent lead naphthenate additive. Life tests were done in dry nitrogen at 50°C. To investigate the MLS-AAA life test anomaly, Spiral Orbit Tribometer (SOT) accelerated tests were performed. SOT results indicated greatly reduced relative lifetimes of Pennzane formulations in contact with 17-4 PH steel compared to 440C stainless steel. Also, dry nitrogen tests yielded longer relative lifetimes than comparable ultrahigh vacuum tests. Generally, oxidized Pennzane formulations yielded shorter lifetimes than non-oxidized lubricant. This study emphasizes surface chemistry effects on the lubricated lifetime of moving mechanical assemblies.

The Effect of 17-4 PH Stainless Steel on the Lifetime of a Pennzane(Trademark) Lubricated Microwave Limb Sounder Antenna Actuator Assembly Ball Screw for the AURA Spacecraft

NASA Technical Reports Server (NTRS)

Jones, William R., Jr.; Jansen, Mark J.; Chen, Gun-Shing; Lam, Jonathan; Balzer, Mark; Anderson, Mark; Lo, John; Schepis, Joseph P.

2005-01-01

During ground based life testing of a Microwave Limb Sounder (MLS) Antenna Actuator Assembly (AAA) ball-screw assembly, lubricant darkening and loss were noted when approximately 10 percent of required lifetime was completed. The MLS-AAA ball screw and nut are made from 17-4 PH steel, the nut has 440C stainless steel balls, and the assembly is lubricated with a Pennzane formulation containing a three weight percent lead naphthenate additive. Life tests were done in dry nitrogen at 50 C. To investigate the MLS-AAA life test anomaly, Spiral Orbit Tribometer (SOT) accelerated tests were performed. SOT results indicated greatly reduced relative lifetimes of Pennzane formulations in contact with 17-4 PH steel compared to 440C stainless steel. Also, dry nitrogen tests yielded longer relative lifetimes than comparable ultrahigh vacuum tests. Generally, oxidized Pennzane formulations yielded shorter lifetimes than non-oxidized lubricant. This study emphasizes surface chemistry effects on the lubricated lifetime of moving mechanical assemblies.

Hyperbaric oxygen for post-concussive symptoms in United States military service members: a randomized clinical trial.

PubMed

Weaver, Lindell K; Wilson, Steffanie H; Lindblad, Anne S; Churchill, Susan; Deru, Kayla; Price, Robert C; Williams, Chris S; Orrison, William W; Walker, James M; Meehan, Anna; Mirow, Susan

2018-01-01

In prior military randomized trials, participants with persistent symptoms after mild traumatic brain injury (TBI) reported improvement regardless of receiving hyperbaric oxygen (HBO₂) or sham intervention. This study's objectives were to identify outcomes for future efficacy trials and describe changes by intervention. This Phase II, randomized, double-blind, sham-controlled trial enrolled military personnel with mild TBI and persistent post-concussive symptoms. Participants were randomized to receive 40 HBO₂ (1.5 atmospheres absolute (ATA), ⟩99% oxygen, 60 minutes) or sham chamber sessions (1.2 ATA, room air, 60 minutes) over 12 weeks. Participants and evaluators were blinded to allocation. Outcomes assessed at baseline, 13 weeks and six months included symptoms, quality of life, neuropsychological, neurological, electroencephalography, sleep, auditory, vestibular, autonomic, visual, neuroimaging, and laboratory testing. Participants completed 12-month questionnaires. Intention-to-treat results are reported. From 9/11/2012 to 5/19/2014, 71 randomized participants received HBO₂ (n=36) or sham (n=35). At baseline, 35 participants (49%) met post-traumatic stress disorder (PTSD) criteria. By the Neurobehavioral Symptom Inventory, the HBO₂ group had improved 13-week scores (mean change -3.6 points, P=0.03) compared to sham (+3.9 points). In participants with PTSD, change with HBO₂ was more pronounced (-8.6 vs. +4.8 points with sham, P=0.02). PTSD symptoms also improved in the HBO₂ group, and more so in the subgroup with PTSD. Improvements regressed at six and 12 months. Hyperbaric oxygen improved some cognitive processing speed and sleep measures. Participants with PTSD receiving HBO₂ had improved functional balance and reduced vestibular complaints at 13 weeks. By 13 weeks, HBO₂ improved post-concussive and PTSD symptoms, cognitive processing speed, sleep quality, and balance function, most dramatically in those with PTSD. Changes did not persist beyond six months. Several outcomes appeared sensitive to change; additional studies are warranted. Copyright© Undersea and Hyperbaric Medical Society.

A Testlet Assembly Design for Adaptive Multistage Tests

ERIC Educational Resources Information Center

Luecht, Richard; Brumfield, Terry; Breithaupt, Krista

2006-01-01

This article describes multistage tests and some practical test development considerations related to the design and implementation of a multistage test, using the Uniform CPA (certified public accountant) Examination as a case study. The article further discusses the use of automated test assembly procedures in an operational context to produce…

Evaluating the toxicity of food processing wastes as co-digestion substrates with dairy manure.

PubMed

Lisboa, Maria Sol; Lansing, Stephanie

2014-07-01

Studies have shown that including food waste as a co-digestion substrate in the anaerobic digestion of livestock manure can increase energy production. However, the type and inclusion rate of food waste used for co-digestion need to be carefully considered in order to prevent adverse conditions in the digestion environment. This study determined the effect of increasing the concentration (2%, 5%, 15% and 30%, by volume) of four food-processing wastes (meatball, chicken, cranberry and ice cream processing wastes) on methane production. Anaerobic toxicity assay (ATA) and specific methanogenic activity (SMA) tests were conducted to determine the concentration at which each food waste became toxic to the digestion environment. Decreases in methane production were observed at concentrations above 5% for all four food waste substrates, with up to 99% decreases in methane production at 30% food processing wastes (by volume). Copyright © 2014 Elsevier Ltd. All rights reserved.

The SLS Stages Intertank Structural Test Assembly (STA) arrives at MSFC

NASA Image and Video Library

2018-03-08

The SLS Stages Intertank Structural Test Assembly (STA) is rolling off the NASA Pegasus Barge at the MSFC Dock enroute to the MSFC 4619 Load Test Annex test facility for qualification testing via MSFC West Test Area. Historic Saturn 1-C test stand on far left, blockhouse 4670 on far right, SLS LH2 test stand, 4693, in center.

The SLS Stages Intertank Structural Test Assembly (STA) arrives at MSFC

NASA Image and Video Library

2018-03-08

The SLS Stages Intertank Structural Test Assembly (STA) is rolling off the NASA Pegasus Barge at the MSFC Dock enroute to the MSFC 4619 Load Test Annex test facility for qualification testing via MSFC West Test Area. STA enters West Test Area from intersection of Dodd and Saturn roads. Onlookers take photos with Historic Dynamic Test Stand in background.

Multiparameter vision testing apparatus

NASA Technical Reports Server (NTRS)

Hunt, S. R., Jr.; Homkes, R. J.; Poteate, W. B.; Sturgis, A. C. (Inventor)

1975-01-01

Compact vision testing apparatus is described for testing a large number of physiological characteristics of the eyes and visual system of a human subject. The head of the subject is inserted into a viewing port at one end of a light-tight housing containing various optical assemblies. Visual acuity and other refractive characteristics and ocular muscle balance characteristics of the eyes of the subject are tested by means of a retractable phoroptor assembly carried near the viewing port and a film cassette unit carried in the rearward portion of the housing (the latter selectively providing a variety of different visual targets which are viewed through the optical system of the phoroptor assembly). The visual dark adaptation characteristics and absolute brightness threshold of the subject are tested by means of a projector assembly which selectively projects one or both of a variable intensity fixation target and a variable intensity adaptation test field onto a viewing screen located near the top of the housing.

Flip-chip assembly and reliability using gold/tin solder bumps

NASA Astrophysics Data System (ADS)

Oppermann, Hermann; Hutter, Matthias; Klein, Matthias; Reichl, Herbert

2004-09-01

Au/Sn solder bumps are commonly used for flip chip assembly of optoelectronic and RF devices. They allow a fluxless assembly which is required to avoid contamination at optical interfaces. Flip chip assembly experiments were carried out using as plated Au/Sn bumps without prior bump reflow. An RF and reliability test vehicles comprise a GaAs chip which was flip chip soldered on a silicon substrate. Temperature cycling tests with and without underfiller were performed and the results are presented. The different failure modes for underfilled and non-underfilled samples were discussed and compared. Additional reliability tests were performed with flip chip bonding by gold thermocompression for comparison. The test results and the failure modes are discussed in detail.

INSTALLATION AT FRANKFURT OF A RECEIVING STATION FOR THE TRANSIT PROGRAM, PHASE I

DTIC Science & Technology

ata. The 2 receivers cover the range between 53 and 262 mc that includes satelite frequencies of 54, 108, 162 and 216 mc, except 324 mc. It wil be...E 390 envisaged for the reception of standard frequencies and time signals, satelites can be observed at a frequency of 20 mc (using a sepaate local

76 FR 63161 - Airworthiness Directives; Aviointeriors S.p.A. Passenger Seat 12M Series, Installed on But Not...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-12

... of the United States Code specifies the FAA's authority to issue rules on aviation safety. Subtitle I... proposed actions to address it. Subject (d) Air Transport Association (ATA) of America Code 25: Equipment...,400--04013 Tor Tre Ponti, Italy; telephone 0039-0773- 689330 or 0039-0773-689291; fax 0039-0773-631546...

Primary Health Care. Report of the International Conference on Primary Health Care, Alma-Ata, USSR, 6-12 September 1978.

ERIC Educational Resources Information Center

World Health Organization, Geneva (Switzerland).

A summary of proceedings is presented from an international conference which focused on the needs and problems of primary health care. The report describes background of the conference, attendance, a summary of discussions, and recommendations. Sponsored by the World Health Organization and UNICEF, the conference was attended by delegations from…

Beyond Piñatas, Fortune Cookies, and Wooden Shoes: Using the World Wide Web to Help Children Explore the Whole Wide World

ERIC Educational Resources Information Center

Kirkwood, Donna; Shulsky, Debra; Willis, Jana

2014-01-01

The advent of technology and access to the internet through the World Wide Web have stretched the traditional ways of teaching social studies beyond classroom boundaries. This article explores how teachers can create authentic and contextualized cultural studies experiences for young children by integrating social studies and technology. To…

75 FR 78588 - Airworthiness Directives; The Boeing Company Model 777-200, -300, and -300ER Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-16

... (ATA), on behalf of its member Delta Air Lines Inc. (Delta), asked that the 60-month compliance time in the supplemental NPRM be extended to better align with industry standard tank entry intervals. Delta stated that the required modifications will require entry into the main and center fuel tanks, and Delta...

75 FR 34663 - Airworthiness Directives; The Boeing Company Model 777-200, -300, and -300ER Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-18

... Association (ATA) on behalf of its member Delta Air Lines Inc. (Delta) asks that we consider reviewing the compliance time to better align with industry standard tank entry intervals. Delta notes that the... intervals; and the center tank is opened at 4-year intervals. Delta states that the 60-month compliance time...

Security Strategy of the Bureau of Diplomatic Security.

DTIC Science & Technology

2011-06-10

Williams, M.A. , Member John A. Dyson, MBA , Member Gregory Scott Hospodor, Ph.D Accepted this 10th day of June 2011 by...ACRONYMS AAR After Action Review ASOS Advance Security Overseas Seminar ATA Antiterrorism Assistance Program BRSO Regional Security Officer Course ...BSAC Basic Special Agent Course DS Bureau of Diplomatic Security FACT Foreign Affairs Counter Threat FAH Foreign Affairs Handbook FAM Foreign

JPRS Report, Science & Technology, USSR: Computers, Control Systems and Machines

DTIC Science & Technology

1989-03-14

optimizatsii slozhnykh sistem (Coding Theory and Complex System Optimization ). Alma-Ata, Nauka Press, 1977, pp. 8-16. 11. Author’s certificate number...Interpreter Specifics [0. I. Amvrosova] ............................................. 141 Creation of Modern Computer Systems for Complex Ecological...processor can be designed to decrease degradation upon failure and assure more reliable processor operation, without requiring more complex software or

The Effect of Corpus-Based Activities on Verb-Noun Collocations in EFL Classes

ERIC Educational Resources Information Center

Ucar, Serpil; Yükselir, Ceyhun

2015-01-01

This current study sought to reveal the impacts of corpus-based activities on verb-noun collocation learning in EFL classes. This study was carried out on two groups--experimental and control groups- each of which consists of 15 students. The students were preparatory class students at School of Foreign Languages, Osmaniye Korkut Ata University.…

Summary Report on NRL Participation in the Microwave Landing System Program.

DTIC Science & Technology

1980-08-19

shifters were measured and statistically analyzed. Several research contracts for promising phased array techniques were awarded to industrial contractors...program was written for compiling statistical data on the measurements, which reads out inser- sertion phase characteristics and standard deviation...GLOSSARY OF TERMS ALPA Airline Pilots’ Association ATA Air Transport Association AWA Australiasian Wireless Amalgamated AWOP All-weather Operations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harp, G. R.; Richards, Jon; Tarter, Jill C.

We report radio SETI observations on a large number of known exoplanets and other nearby star systems using the Allen Telescope Array (ATA). Observations were made over about 19000 hr from 2009 May to 2015 December. This search focused on narrowband radio signals from a set totaling 9293 stars, including 2015 exoplanet stars and Kepler objects of interest and an additional 65 whose planets may be close to their habitable zones. The ATA observations were made using multiple synthesized beams and an anticoincidence filter to help identify terrestrial radio interference. Stars were observed over frequencies from 1 to 9 GHzmore » in multiple bands that avoid strong terrestrial communication frequencies. Data were processed in near-real time for narrowband (0.7–100 Hz) continuous and pulsed signals with transmitter/receiver relative accelerations from −0.3 to 0.3 m s{sup −2}. A total of 1.9 × 10{sup 8} unique signals requiring immediate follow-up were detected in observations covering more than 8 × 10{sup 6} star-MHz. We detected no persistent signals from extraterrestrial technology exceeding our frequency-dependent sensitivity threshold of 180–310 × 10{sup −26} W m{sup −2}.« less

Relationship between antithyroid antibody and pregnancy outcome following in vitro fertilization and embryo transfer.

PubMed

Zhong, Yi-ping; Ying, Ying; Wu, Hai-tao; Zhou, Can-quan; Xu, Yan-wen; Wang, Qiong; Li, Jie; Shen, Xiao-ting; Li, Jin

2012-01-01

To investigate the impact of antithyroid antibody on pregnancy outcome following the in vitro fertilization and embryo transfer (IVF-ET). A total of 90 patients (156 cycles) positive for antithyroid antibody (ATA+ group) and 676 infertile women (1062 cycles) negative for antithyroid antibody (ATA- group) undergoing IVF/ICSI from August 2009 to August 2010 were retrospectively analyzed. There was no significant difference in the days of ovarian stimulation, total gonadotropin dose, serum E2 level of HCG day and number of oocytes retrieved between the two groups. The fertilization rate, implantation rate and pregnancy rate following IVF-ET were significantly lower in women with antithyroid antibody than in control group (64.3% vs 74.6%, 17.8% vs 27.1% and 33.3% vs 46.7%, respectively), but the abortion rate was significantly higher in patients with antithyroid antibody (26.9% vs 11.8%). Patients with antithyroid antibody showed significantly lower fertilization rate, implantation rate and pregnancy rate and higher risk for abortion following IVF-ET when compared with those without antithyroid antibody. Thus, the presence of antithyroid antibody is detrimental for the pregnancy outcome following IVF-ET.

Relationship between Antithyroid Antibody and Pregnancy Outcome following in Vitro Fertilization and Embryo Transfer

PubMed Central

Zhong, Yi-ping; Ying, Ying; Wu, Hai-tao; Zhou, Can-quan; Xu, Yan-wen; Wang, Qiong; Li, Jie; Shen, Xiao-ting; Li, Jin

2012-01-01

Objective: To investigate the impact of antithyroid antibody on pregnancy outcome following the in vitro fertilization and embryo transfer (IVF-ET). Methods: A total of 90 patients (156 cycles) positive for antithyroid antibody (ATA+ group) and 676 infertile women (1062 cycles) negative for antithyroid antibody (ATA- group) undergoing IVF/ICSI from August 2009 to August 2010 were retrospectively analyzed. Results: There was no significant difference in the days of ovarian stimulation, total gonadotropin dose, serum E2 level of HCG day and number of oocytes retrieved between the two groups. The fertilization rate, implantation rate and pregnancy rate following IVF-ET were significantly lower in women with antithyroid antibody than in control group (64.3% vs 74.6%, 17.8% vs 27.1% and 33.3% vs 46.7%, respectively), but the abortion rate was significantly higher in patients with antithyroid antibody (26.9% vs 11.8%). Conclusion: Patients with antithyroid antibody showed significantly lower fertilization rate, implantation rate and pregnancy rate and higher risk for abortion following IVF-ET when compared with those without antithyroid antibody. Thus, the presence of antithyroid antibody is detrimental for the pregnancy outcome following IVF-ET. PMID:22253557

Private payer telehealth reimbursement in the United States.

PubMed

Antoniotti, Nina M; Drude, Kenneth P; Rowe, Nancy

2014-06-01

Significant information is available about government-reimbursed telehealth services such as Medicare and Medicaid across the United States. Although currently 20 states mandate reimbursement for telehealth services and some private insurers have voluntarily covered those services in other states, relatively little is known about telehealth provider experiences with reimbursement from private insurance payers. To investigate this, the American Telemedicine Association's (ATA's) Telemental Health Special Interest Group (SIG), the Policy Group, and the Business and Finance SIG, with the help of ATA staff, conducted a national private payer reimbursement online survey in 2012 using Survey Monkey™ (Palo Alto, CA) ( www.surveymonkey.com/ ). Survey responses were received from respondents in 46 of the 50 states. The survey found that telehealth services are being reimbursed by private payers but that progress in reimbursement has been relatively slow compared with earlier surveys. Key findings from this study were that government payers as well as several major private payers are highly influential in payment policies for telehealth private payers, that private payers have administrative rules regarding telehealth reimbursement that are barriers to services and reimbursement, and that some providers would benefit from being better informed about billing and coding for telehealth services and how to advocate for telehealth services reimbursement.

Reconstructing the critically damaged health service system of the country.

PubMed

Banerji, Debabar

2012-01-01

India's ruling class, in association with international agencies, bureaucrats, and business interests, has formed a powerful syndicate that has been imposing its will on the country to the detriment of public health. After gaining independence, India developed a body of knowledge suited to its social, cultural, economic, and epidemiological conditions. This led to an alternative approach to public health education, practice, and research that foreshadowed the Alma Ata Declaration on Primary Health Care of 1978. In the early 1980s, global power shifts undermined national and international commitment to the Declaration. Wealthy countries' response to the declaration of self-reliance by economically disadvantaged countries was swift: an effort to suppress the Declaration's ideals in favor of an unscientific, market-driven agenda. As a result, public health practice in India virtually disappeared. Responding to growing restiveness among a population in need, political leaders have launched the foredoomed National Rural Health Mission and pursued an American brand of public health through the Public Health Foundation of India. Reconstructing the damaged public health system will require pressure on the syndicate to ensure India's public health heritage will be used to effectively transfer "People's health in people's hands" according to the guidelines set down at Alma Ata.

Oxidation state and interfacial effects on oxygen vacancies in tantalum pentoxide

DOE PAGES

Bondi, Robert J.; Marinella, Matthew J.

2015-02-28

First-principles density-functional theory (DFT) calculations are used to study the atomistic structure, structural energetics, and electron density near the O monovacancy (V O n; n=0,1+,2+) in both bulk, amorphous tantalum pentoxide (a-Ta 2O 5) and also at vacuum and metallic Ta interfaces. We calculate multivariate vacancy formation energies to evaluate stability as a function of oxidation state, distance from interface plane, and Fermi energy. V O n of all oxidation states preferentially segregate at both Ta and vacuum interfaces, where the metallic interface exhibits global formation energy minima. In a-Ta 2O 5, V O 0 are characterized by structural contractionmore » and electron density localization, while V O 2+ promote structural expansion and are depleted of electron density. In contrast, interfacial V O 0 and V O 2+ show nearly indistinguishable ionic and electronic signatures indicative of a reduced V O center. Interfacial V O 2+ extract electron density from metallic Ta indicating V O 2+ is spontaneously reduced at the expense of the metal. This oxidation/reduction behavior suggests careful selection and processing of both oxide layer and metal electrodes for engineering memristor device operation.« less

Evaluation of blood adsorption onto dialysis membranes by time-of-flight secondary ion mass spectrometry and near-field infrared microscopy.

PubMed

Aoyagi, Satoka; Abe, Kiyoshi; Yamagishi, Takayuki; Iwai, Hideo; Yamaguchi, Satoru; Sunohara, Takashi

2017-11-01

Blood adsorption onto the inside surface of hollow fiber dialysis membranes was investigated by means of time-of-flight secondary ion mass spectrometry (TOF-SIMS) and near-field infrared microscopy (NFIR) in order to evaluate the biocompatibility and permeability of dialysis membranes. TOF-SIMS is useful for the imaging of particular molecules with a high spatial resolution of approximately 100 nm. In contrast, infrared spectra provide quantitative information and NFIR enables analysis with a high spatial resolution of less than 1 μm, which is close to the resolution of TOF-SIMS. A comparison was made of one of the most widely used dialysis membranes made of polysulfone (PSf), that has an asymmetric and inhomogeneous pore structure, and a newly developed asymmetric cellulose triacetate (ATA) membrane that also has an asymmetric pore structure, even though the conventional cellulose triacetate membrane has a symmetric and homogeneous pore structure. As a result, it was demonstrated that blood adsorption on the inside surface of the ATA membrane is more reduced than that on the PSf membrane. Graphical abstract Analysis of blood adsorption on inside surface of hollow fiber membrane.

Differences in community composition of bacteria in four glaciers in western China

NASA Astrophysics Data System (ADS)

An, L. Z.; Chen, Y.; Xiang, S.-R.; Shang, T.-C.; Tian, L.-D.

2010-06-01

Microbial community patterns vary in glaciers worldwide, presenting unique responses to global climatic and environmental changes. Four bacterial clone libraries were established by 16S rRNA gene amplification from four ice layers along the 42-m-long ice core MuztB drilled from the Muztag Ata Glacier. A total of 151 bacterial sequences obtained from the ice core MuztB were phylogenetically compared with the 71 previously reported sequences from three ice cores extracted from ice caps Malan, Dunde, and Puruogangri. Six phylogenetic clusters Flavisolibacter, Flexibacter (Bacteroidetes), Acinetobacter, Enterobacter (Gammaproteobacteria), Planococcus/Anoxybacillus (Firmicutes), and Propionibacter/Luteococcus (Actinobacteria) frequently occurred along the Muztag Ata Glacier profile, and their proportion varied by seasons. Sequence analysis showed that most of the sequences from the ice core clustered with those from cold environments, and the sequence clusters from the same glacier more closely grouped together than those from the geographically isolated glaciers. Moreover, bacterial communities from the same location or similarly aged ice formed a cluster, and were clearly separate from those from other geographically isolated glaciers. In summary, the findings provide preliminary evidence of zonal distribution of microbial community, and suggest biogeography of microorganisms in glacier ice.

Differences in community composition of bacteria in four deep ice sheets in western China

NASA Astrophysics Data System (ADS)

An, L.; Chen, Y.; Xiang, S.-R.; Shang, T.-C.; Tian, L.-De

2010-02-01

Microbial community patterns vary in glaciers world wide, presenting unique responses to global climatic and environmental changes. Four bacterial clone libraries were established by 16S rRNA gene amplification from four ice layers along the 42-m-long ice core MuztB drilled from the Muztag Ata Glacier. A total of 152 bacterial sequences obtained from the ice core MuztB were phylogenetically compared with the 71 previously reported sequences from three ice cores extracted from ice caps Malan, Dunde, and Puruoganri. The six functional clusters Flavisolibacter, Flexibacter (Bacteroidetes), Acinetobacter, Enterobacter (Gammaproteobacteria), Planococcus/Anoxybacillus (Firmicutes), and Propionibacter/Luteococcus (Actinobacteria) frequently occurred along the Muztag Ata Glacier profile. Sequence analysis showed that most of the sequences from the ice core clustered with those from cold environments, and the sequences from the same glacier formed a distinct cluster. Moreover, bacterial communities from the same location or similarly aged ice formed a cluster, and were clearly separate from those from other geographically isolated glaciers. In a summary, the findings provide preliminary evidence of zone distribution of microbial community, support our hypothesis of the spatial and temporal biogeography of microorganisms in glacial ice.

Crystal Structure and Thermoelectric Properties of β-Pyrochlore-Type Alkali Iron Tungsten Oxides with Cage-Like Structure

NASA Astrophysics Data System (ADS)

Mizuta, Kohei; Ohtaki, Michitaka

2016-03-01

We report the electrical and thermal properties of β-pyrochlore (defect pyrochlore) oxides AFe0.33W1.67O6 ( A = K, Rb, Cs) with a crystal structure having a small cation surrounded by oversized cage-like framework. The thermal conductivity, κ, of CsFe0.33W1.67O6 and RbFe0.33W1.67O6 showed extremely low values as oxides (below 1.0 W/mK) similar to those of ATaWO6 ( A = K, Rb, Cs) which we have already reported. These low κ values are ascribed to a "rattling" motion of the A cations, evidenced by their crystal structure refinement and the Raman spectra. Their electrical conductivity, σ, was in the order of 10-3 S/cm, and the Seebeck coefficient, S, was -500 to -600 μV/K. The electrical conductivity of AFe0.33W1.67O6 ( A = Rb, Cs) was much higher than those of ATaWO6 ( A = Rb, Cs), suggesting that an appropriate selection of the framework composition enables us to have better thermoelectric performance.

Management of primary hypothyroidism: statement by the British Thyroid Association Executive Committee.

PubMed

Okosieme, Onyebuchi; Gilbert, Jackie; Abraham, Prakash; Boelaert, Kristien; Dayan, Colin; Gurnell, Mark; Leese, Graham; McCabe, Christopher; Perros, Petros; Smith, Vicki; Williams, Graham; Vanderpump, Mark

2016-06-01

The management of primary hypothyroidism with levothyroxine (L-T4) is simple, effective and safe, and most patients report improved well-being on initiation of treatment. However, a proportion of individuals continue to suffer with symptoms despite achieving adequate biochemical correction. The management of such individuals has been the subject of controversy and of considerable public interest. The American Thyroid Association (ATA) and the European Thyroid Association (ETA) have recently published guidelines on the diagnosis and management of hypothyroidism. These guidelines have been based on extensive reviews of the medical literature and include sections on the role of combination therapy with L-T4 and liothyronine (L-T3) in individuals who are persistently dissatisfied with L-T4 therapy. This position statement by the British Thyroid Association (BTA) summarises the key points in these guidelines and makes recommendations on the management of primary hypothyroidism based on the current literature, review of the published positions of the ETA and ATA, and in line with best principles of good medical practice. The statement is endorsed by the Association of Clinical Biochemistry, (ACB), British Thyroid Foundation, (BTF), Royal College of Physicians (RCP) and Society for Endocrinology (SFE). © 2015 John Wiley & Sons Ltd.

Aspirin induces IL-4 production: augmented IL-4 production in aspirin-exacerbated respiratory disease

PubMed Central

Kong, Su-Kang; Soo Kim, Byung; Gi Uhm, Tae; Soo Chang, Hun; Sook Park, Jong; Woo Park, Sung; Park, Choon-Sik; Chung, Il Yup

2016-01-01

Aspirin hypersensitivity is a hallmark of aspirin-exacerbated respiratory disease (AERD), a clinical syndrome characterized by the severe inflammation of the respiratory tract after ingestion of cyclooxygenase-1 inhibitors. We investigated the capacity of aspirin to induce interleukin-4 (IL-4) production in inflammatory cells relevant to AERD pathogenesis and examined the associated biochemical and molecular pathways. We also compared IL-4 production in peripheral blood mononuclear cells (PBMCs) from patients with AERD vs aspirin-tolerant asthma (ATA) upon exposure to aspirin. Aspirin induced IL-4 expression and activated the IL-4 promoter in a report assay. The capacity of aspirin to induce IL-4 expression correlated with its activity to activate mitogen-activated protein kinases, to form DNA–protein complexes on P elements in the IL-4 promoter and to synthesize nuclear factor of activated T cells, critical transcription factors for IL-4 transcription. Of clinical importance, aspirin upregulated IL-4 production twice as much in PBMCs from patients with AERD compared with PBMCs from patients with ATA. Our results suggest that IL-4 is an inflammatory component mediating intolerance reactions to aspirin, and thus is crucial for AERD pathogenesis. PMID:27534531

49 CFR 572.192 - Head assembly.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 7 2014-10-01 2014-10-01 false Head assembly. 572.192 Section 572.192... Test Dummy, Small Adult Female § 572.192 Head assembly. (a) The head assembly consists of the head (180...) of this section, the head assembly shall meet performance requirements specified in paragraph (c) of...

49 CFR 572.182 - Head assembly.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 7 2014-10-01 2014-10-01 false Head assembly. 572.182 Section 572.182... Test Dummy, 50th Percentile Adult Male § 572.182 Head assembly. (a) The head assembly consists of the..., the head assembly shall meet performance requirements specified in paragraph (c) of this section. (b...

49 CFR 572.182 - Head assembly.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 7 2010-10-01 2010-10-01 false Head assembly. 572.182 Section 572.182... Dummy, 50th Percentile Adult Male § 572.182 Head assembly. (a) The head assembly consists of the head... assembly shall meet performance requirements specified in paragraph (c) of this section. (b) Test procedure...

49 CFR 572.182 - Head assembly.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 7 2011-10-01 2011-10-01 false Head assembly. 572.182 Section 572.182... Dummy, 50th Percentile Adult Male § 572.182 Head assembly. (a) The head assembly consists of the head... assembly shall meet performance requirements specified in paragraph (c) of this section. (b) Test procedure...

49 CFR 572.192 - Head assembly.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 7 2013-10-01 2013-10-01 false Head assembly. 572.192 Section 572.192... Test Dummy, Small Adult Female § 572.192 Head assembly. (a) The head assembly consists of the head (180...) of this section, the head assembly shall meet performance requirements specified in paragraph (c) of...

49 CFR 572.182 - Head assembly.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 7 2012-10-01 2012-10-01 false Head assembly. 572.182 Section 572.182... Dummy, 50th Percentile Adult Male § 572.182 Head assembly. (a) The head assembly consists of the head... assembly shall meet performance requirements specified in paragraph (c) of this section. (b) Test procedure...

49 CFR 572.182 - Head assembly.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 7 2013-10-01 2013-10-01 false Head assembly. 572.182 Section 572.182... Test Dummy, 50th Percentile Adult Male § 572.182 Head assembly. (a) The head assembly consists of the..., the head assembly shall meet performance requirements specified in paragraph (c) of this section. (b...

Integrating Test-Form Formatting into Automated Test Assembly

ERIC Educational Resources Information Center

Diao, Qi; van der Linden, Wim J.

2013-01-01

Automated test assembly uses the methodology of mixed integer programming to select an optimal set of items from an item bank. Automated test-form generation uses the same methodology to optimally order the items and format the test form. From an optimization point of view, production of fully formatted test forms directly from the item pool using…

49 CFR 572.166 - Knees and knee impact test procedure.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 7 2010-10-01 2010-10-01 false Knees and knee impact test procedure. 572.166... Hybrid III Six-Year-Old Weighted Child Test Dummy § 572.166 Knees and knee impact test procedure. The knee assembly is assembled and tested as specified in 49 CFR 572.126 (Subpart N). ...

Evaluating Statistical Targets for Assembling Parallel Mixed-Format Test Forms

ERIC Educational Resources Information Center

Debeer, Dries; Ali, Usama S.; van Rijn, Peter W.

2017-01-01

Test assembly is the process of selecting items from an item pool to form one or more new test forms. Often new test forms are constructed to be parallel with an existing (or an ideal) test. Within the context of item response theory, the test information function (TIF) or the test characteristic curve (TCC) are commonly used as statistical…

7. PHOTOCOPY, PLANS, ELEVATIONS, AND SECTION DRAWING FOR MISSILE TEST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. PHOTOCOPY, PLANS, ELEVATIONS, AND SECTION DRAWING FOR MISSILE TEST AND ASSEMBLY BUILDING. - NIKE Missile Base SL-40, Missile Test & Assembly Building, South end of launch area, northeast of Generator Building No. 3, Hecker, Monroe County, IL

International Space Station Carbon Dioxide Removal Assembly Testing

NASA Technical Reports Server (NTRS)

Knox, James C.

2000-01-01

Performance testing of the International Space Station Carbon Dioxide Removal Assembly flight hardware in the United States Laboratory during 1999 is described. The CDRA exceeded carbon dioxide performance specifications and operated flawlessly. Data from this test is presented.

49 CFR 572.175 - Upper and lower torso assemblies and torso flexion test procedure.

Code of Federal Regulations, 2012 CFR

2012-10-01

.../lower torso assembly is as follows: (1) Torque the lumbar cable (drawing 420-4130) (incorporated by... threaded attachment holes. Tighten the mountings so that the test material is rigidly affixed to the test...

49 CFR 572.175 - Upper and lower torso assemblies and torso flexion test procedure.

Code of Federal Regulations, 2013 CFR

2013-10-01

.../lower torso assembly is as follows: (1) Torque the lumbar cable (drawing 420-4130) (incorporated by... threaded attachment holes. Tighten the mountings so that the test material is rigidly affixed to the test...

49 CFR 572.175 - Upper and lower torso assemblies and torso flexion test procedure.

Code of Federal Regulations, 2014 CFR

2014-10-01

.../lower torso assembly is as follows: (1) Torque the lumbar cable (drawing 420-4130) (incorporated by... threaded attachment holes. Tighten the mountings so that the test material is rigidly affixed to the test...

Development of assembly techniques for fire resistant aircraft interior panels

NASA Technical Reports Server (NTRS)

Lee, S. C. S.

1978-01-01

Ten NASA Type A fire resistant aircraft interior panels were fabricated and tested to develop assembly techniques. These techiques were used in the construction of a full scale lavatory test structure for flame propagation testing. The Type A panel is of sandwich construction consisting of Nomex honeycomb filled with quinone dioxime foam, and bismaleimide/glass face sheets bonded to the core with polyimide film adhesive. The materials selected and the assembly techniques developed for the lavatory test structure were designed for obtaining maximum fire containment with minimum smoke and toxic emission.

Internally damped, self-arresting vertical drop-weight apparatus

NASA Technical Reports Server (NTRS)

Ambur, Damodar R. (Inventor); Prasad, Chunchu B. (Inventor); Waters, William A. (Inventor); Stockum, Robert W. (Inventor); Walter, Manfred A. (Inventor)

1994-01-01

A vertical dropped-weight impact test machine has a dropped-weight barrel vertically supported on upper and lower support brackets. The dropped-weight barrel is chambered to receive a dropped-weight assembly having a latch pin at its upper end, a damping unit in the middle, and a tup at its lower end. The tup is adapted for gathering data during impact testing. The latch pin releasably engages a latch pin coupling assembly. The latch pin coupling assembly is attached to a winch via a halyard for raising and lowering the dropped-weight assembly. The lower end of the dropped-weight barrel is provided with a bounce-back arresting mechanism which is activated by the descending passage of the dropped-weight assembly. After striking the specimen, the dropped-weight assembly rebounds vertically and is caught by the bounce-back arresting mechanism. The damping unit of the dropped-weight assembly serves to dissipate energy from the rebounding dropped-weight assembly and prevents the dropped-weight assembly from rebounding from the self-arresting mechanism.

Fabrication of fuel pin assemblies, phase 3

NASA Technical Reports Server (NTRS)

Keeton, A. R.; Stemann, L. G.

1972-01-01

Five full size and eight reduced length fuel pins were fabricated for irradiation testing to evaluate design concepts for a fast spectrum lithium cooled compact space power reactor. These assemblies consisted of uranium mononitride fuel pellets encased in a T-111 (Ta-8W-2Hf) clad with a tungsten barrier separating fuel and clad. Fabrication procedures were fully qualified by process development and assembly qualification tests. Detailed specifications and procedures were written for the fabrication and assembly of prototype fuel pins.

James Webb Space Telescope: Frequently Asked Questions for Scientists and Engineers

NASA Technical Reports Server (NTRS)

Gardner, Jonathan P.

2008-01-01

JWST will be tested incrementally during its construction, starting with individual mirrors and instruments (including cameras and spectrometers) and building up to the full observatory. JWST's mirrors and the telescope structure are first each tested individually, including optical testing of the mirrors and alignment testing of the structure inside a cold thermal-vacuum chamber. The mirrors are then installed on the telescope structure in a clean room at Goddard Space Flight Center (GSFC). In parallel to the telescope assembly and alignment, the instruments are being built and tested, again first individually, and then as part of an integrated instrument assembly. The integrated instrument assembly will be tested in a thermal-vacuum chamber at GSFC using an optical simulator of the telescope. This testing makes sure the instruments are properly aligned relative to each other and also provides an independent check of the individual tests. After both the telescope and the integrated instrument module are successfully assembled, the integrated instrument module will be installed onto the telescope, and the combined system will be sent to Johnson Space Flight Center (JSC) where it will be optically tested in one of the JSC chambers. The process includes testing the 18 primary mirror segments acting as a single primary mirror, and testing the end-to-end system. The final system test will assure that the combined telescope and instruments are focused and aligned properly, and that the alignment, once in space, will be within the range of the actively controlled optics. In general, the individual optical tests of instruments and mirrors are the most accurate. The final system tests provide a cost-effective check that no major problem has occurred during assembly. In addition, independent optical checks of earlier tests will be made as the full system is assembled, providing confidence that there are no major problems.

A simulation facility for testing Space Station assembly procedures

NASA Technical Reports Server (NTRS)

Hajare, Ankur R.; Wick, Daniel T.; Shehad, Nagy M.

1994-01-01

NASA plans to construct the Space Station Freedom (SSF) in one of the most hazardous environments known to mankind - space. It is of the utmost importance that the procedures to assemble and operate the SSF in orbit are both safe and effective. This paper describes a facility designed to test the integration of the telerobotic systems and to test assembly procedures using a real-world robotic arm grappling space hardware in a simulated microgravity environment.

Development of environmentally conscious cleaning process for leadless chip carrier assemblies. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adams, B.E.

1995-04-01

A cross-functional team of process, product, quality, material, and design lab engineers was assembled to develop an environmentally friendly cleaning process for leadless chip carrier assemblies (LCCAs). Using flush and filter testing, Auger surface analysis, GC-Mass spectrophotometry, production yield results, and electrical testing results over an extended testing period, the team developed an aqueous cleaning process for LCCAs. The aqueous process replaced the Freon vapor degreasing/ultrasonic rinse process.

Introduction and Validation of Chromium-Free Consumables for Welding Stainless Steels. Version 2

DTIC Science & Technology

2015-04-14

12 4.3 Site-related Permits and Regulations .......................................................................... 13 TEST DESIGN ...109 Appendix K: X-ray Report on ENiCuRu Weld Test Assembly...60 Table 6.24 Radiographic Test Report on Baseline E308L-16 and Test ENiCuRu Weld Assemblies

Evaluation of Hardware and Procedures for Astronaut Assembly and Repair of Large Precision Reflectors

NASA Technical Reports Server (NTRS)

Lake, Mark S.; Heard, Walter L., Jr.; Watson, Judith J.; Collins, Timothy J.

2000-01-01

A detailed procedure is presented that enables astronauts in extravehicular activity (EVA) to efficiently assemble and repair large (i.e., greater than 10m-diameter) segmented reflectors, supported by a truss, for space-based optical or radio-frequency science instruments. The procedure, estimated timelines, and reflector hardware performance are verified in simulated 0-g (neutral buoyancy) assembly tests of a 14m-diameter, offset-focus, reflector test article. The test article includes a near-flight-quality, 315-member, doubly curved support truss and 7 mockup reflector panels (roughly 2m in diameter) representing a portion of the 37 total panels needed to fully populate the reflector. Data from the tests indicate that a flight version of the design (including all reflector panels) could be assembled in less than 5 hours - less than the 6 hours normally permitted for a single EVA. This assembly rate essentially matches pre-test predictions that were based on a vast amount of historical data on EVA assembly of structures produced by NASA Langley Research Center. Furthermore, procedures and a tool for the removal and replacement of a damaged reflector panel were evaluated, and it was shown that EVA repair of this type of reflector is feasible with the use of appropriate EVA crew aids.

Safety Evaluation of Self-assembling Peptide Gel after Intracranial Administration to Rats Using the Open Field Test.

PubMed

Tsunoda, Masashi; Sugaya, Chiemi; Sugiura, Yumiko; Nagai, Yusuke; Sakanishi, Kotaro

2016-01-01

Self-assembling peptides have been developed as clinical materials, which could scaffold to regenerate nerve cells and hemostatic materials in vivo. However, there has not been enough information for their in vivo application. The safety of self-assembling peptides for the application on the brain was examined using behavioral tests for each rat in this study. Self-assembling peptide gel was administered to the surface of the brain at a volume of 20 µL at 1.5%. After 2 months, the open field test and the prepulse inhibition (PPI) test were performed. There were no significant differences between the peptide gel and the control groups in locomotor distances and in %PPIs in the PPI test. The mean values of the percentage of time the rats stayed in the central area of the open field during the first 5 min and instances of center rearing or face washing in the peptide gel group were significantly higher than those in the control. There were amorphous substance in the subarachnoid region, and infiltrations of mononuclear cells were also observed in the self-assembling peptide gel group. Although the meaning of the effects observed in this study was not fully elucidated, the self-assembling gel produced marginal but significant behavioral and histological effects.

49 CFR 572.186 - Abdomen assembly.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 7 2013-10-01 2013-10-01 false Abdomen assembly. 572.186 Section 572.186... Test Dummy, 50th Percentile Adult Male § 572.186 Abdomen assembly. (a) The abdomen assembly (175-5000) is part of the dummy assembly shown in drawing 175-0000 including load sensors specified in § 572.189...

49 CFR 572.112 - Head assembly.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 7 2012-10-01 2012-10-01 false Head assembly. 572.112 Section 572.112... 50th Percentile Male § 572.112 Head assembly. The head assembly consists of the head (drawing 78051-61X...) accelerometers that are mounted in conformance to § 572.36 (c). (a) Test procedure. (1) Soak the head assembly in...

49 CFR 572.112 - Head assembly.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 7 2011-10-01 2011-10-01 false Head assembly. 572.112 Section 572.112... 50th Percentile Male § 572.112 Head assembly. The head assembly consists of the head (drawing 78051-61X...) accelerometers that are mounted in conformance to § 572.36 (c). (a) Test procedure. (1) Soak the head assembly in...

49 CFR 572.112 - Head assembly.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 7 2010-10-01 2010-10-01 false Head assembly. 572.112 Section 572.112... 50th Percentile Male § 572.112 Head assembly. The head assembly consists of the head (drawing 78051-61X...) accelerometers that are mounted in conformance to § 572.36 (c). (a) Test procedure. (1) Soak the head assembly in...

49 CFR 572.112 - Head assembly.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 7 2013-10-01 2013-10-01 false Head assembly. 572.112 Section 572.112... 50th Percentile Male § 572.112 Head assembly. The head assembly consists of the head (drawing 78051-61X...) accelerometers that are mounted in conformance to § 572.36 (c). (a) Test procedure. (1) Soak the head assembly in...

49 CFR 572.112 - Head assembly.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 7 2014-10-01 2014-10-01 false Head assembly. 572.112 Section 572.112... 50th Percentile Male § 572.112 Head assembly. The head assembly consists of the head (drawing 78051-61X...) accelerometers that are mounted in conformance to § 572.36 (c). (a) Test procedure. (1) Soak the head assembly in...

Detail design of the surface tension propellant management device for the Intelsat VII communication satellite

NASA Astrophysics Data System (ADS)

Giacalone, Philip L.

1993-06-01

The design of the Intelsat VII surface tension propellant management device (PMD) (an all-welded assembly consisting of about 100 individual components) was developed using a modular design approach that allowed the complex PMD assembly to be divided into smaller modules. The modular approach reduces manufacturing-related technical and schedule risks and allows many components and assemblies to be processed in parallel, while also facilitating the incorporation of quality assurance tests at all critical PMD subassembly levels. The baseline PMD assembly is made from titanium and stainless steel materials. In order to obtain a 100 percent titanium PMD, a new, state-of-the-art fine mesh titanium screen material was developed, tested, and qualified for use as an alternaltive to the stainless steel screen material. The Ti based screen material demonstrated a high level of bubble point performance. It was integrated into a PMD assembly and was successfully qualification tested at the tank assembly level.

Baseline tests of an autonomous telerobotic system for assembly of space truss structures

NASA Technical Reports Server (NTRS)

Rhodes, Marvin D.; Will, Ralph W.; Quach, Coung

1994-01-01

Several proposed space missions include precision reflectors that are larger in diameter than any current or proposed launch vehicle. Most of these reflectors will require a truss structure to accurately position the reflector panels and these reflectors will likely require assembly in orbit. A research program has been conducted at the NASA Langley Research Center to develop the technology required for the robotic assembly of truss structures. The focus of this research has been on hardware concepts, computer software control systems, and operator interfaces necessary to perform supervised autonomous assembly. A special facility was developed and four assembly and disassembly tests of a 102-strut tetrahedral truss have been conducted. The test procedures were developed around traditional 'pick-and-place' robotic techniques that rely on positioning repeatability for successful operation. The data from two of the four tests were evaluated and are presented in this report. All operations in the tests were controlled by predefined sequences stored in a command file, and the operator intervened only when the system paused because of the failure of an actuator command. The tests were successful in identifying potential pitfalls in a telerobotic system, many of which would not have been readily anticipated or incurred through simulation studies. Addressing the total integrated task, instead of bench testing the component parts, forced all aspects of the task to be evaluated. Although the test results indicate that additional developments should be pursued, no problems were encountered that would preclude automated assembly in space as a viable construction method.

Uniform Test Assembly

ERIC Educational Resources Information Center

Belov, Dmitry I.

2008-01-01

In educational practice, a test assembly problem is formulated as a system of inequalities induced by test specifications. Each solution to the system is a test, represented by a 0-1 vector, where each element corresponds to an item included (1) or not included (0) into the test. Therefore, the size of a 0-1 vector equals the number of items "n"…

LPT. Shield test facility assembly and test building (TAN646), south ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

LPT. Shield test facility assembly and test building (TAN-646), south facade. Camera facing north. High-bay section is pool room. Single-story section at right is control building (TAN-645). Small metal building is post-1970 addition. INEEL negative no. HD-40-7-3 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

The SLS Stages Intertank Structural Test Assembly (STA) arrives at MSFC

NASA Image and Video Library

2018-03-06

The SLS Stages Intertank Structural Test Assembly (STA) is rolling off the NASA Pegasus Barge at the MSFC Dock enroute to the MSFC 4619 Load Test Annex test facility for qualification testing. Members of MSFC Logistics Office and Move Team members gather for last minute instructions and safety briefing before off-loading STA hardware.

A Multiple Objective Test Assembly Approach for Exposure Control Problems in Computerized Adaptive Testing

ERIC Educational Resources Information Center

Veldkamp, Bernard P.; Verschoor, Angela J.; Eggen, Theo J. H. M.

2010-01-01

Overexposure and underexposure of items in the bank are serious problems in operational computerized adaptive testing (CAT) systems. These exposure problems might result in item compromise, or point at a waste of investments. The exposure control problem can be viewed as a test assembly problem with multiple objectives. Information in the test has…

30 CFR 7.45 - Critical characteristics

Code of Federal Regulations, 2011 CFR

2011-07-01

... APPROVAL OF MINING PRODUCTS TESTING BY APPLICANT OR THIRD PARTY Battery Assemblies § 7.45 Critical characteristics The following critical characteristics shall be inspected or tested on each battery assembly to...

30 CFR 7.45 - Critical characteristics

Code of Federal Regulations, 2012 CFR

2012-07-01

... APPROVAL OF MINING PRODUCTS TESTING BY APPLICANT OR THIRD PARTY Battery Assemblies § 7.45 Critical characteristics The following critical characteristics shall be inspected or tested on each battery assembly to...

PBF Reactor Building (PER620). PBF crane holds fuel test assembly ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

PBF Reactor Building (PER-620). PBF crane holds fuel test assembly aloft prior to lowering into reactor for test. Date: 1982. INEEL negative no. 82-4909 - Idaho National Engineering Laboratory, SPERT-I & Power Burst Facility Area, Scoville, Butte County, ID

Hybrid Wing Body Multi-Bay Test Article Analysis and Assembly Final Report

NASA Technical Reports Server (NTRS)

Velicki, Alexander; Hoffman, Krishna; Linton, Kim A.; Baraja, Jaime; Wu, Hsi-Yung T.; Thrash, Patrick

2017-01-01

This report summarizes work performed by The Boeing Company, through its Boeing Research & Technology organization located in Huntington Beach, California, under the Environmentally Responsible Aviation (ERA) project. The report documents work performed to structurally analyze and assemble a large-scale Multi-bay Box (MBB) Test Article capable of withstanding bending and internal pressure loadings representative of a Hybrid Wing Body (HWB) aircraft. The work included fabrication of tooling elements for use in the fabrication and assembly of the test article.

DOE Office of Scientific and Technical Information (OSTI.GOV)

West, W.S.

Progress during the period includes completion of the SNAP 7C system tests, completion of safety analysis for the SNAP 7A and C systems, assembly and initial testing of SNAP 7A, assembly of a modified reliability model, and assembly of a 10-W generator. Other activities include completion of thermal and safety analyses for SNAP 7B and D generators and fuel processing for these generators. (J.R.D.)

Design and Fabrication of Cryostat Interface and Electronics for High Performance Antimatter Trap (HI-PAT)

NASA Technical Reports Server (NTRS)

Smith, Gerald A.

1999-01-01

Included in Appendix I to this report is a complete set of design and assembly schematics for the high vacuum inner trap assembly, cryostat interfaces and electronic components for the MSFC HI-PAT. Also included in the final report are summaries of vacuum tests, and electronic tests performed upon completion of the assembly.

Quality of School Work Life of Public School Teachers: Cases from Turkey and Pakistan

ERIC Educational Resources Information Center

Akram, Muhammad; Ilgan, Abdurrahman; Ozu, Oyku; Shah, Ashfaque Ahmad

2017-01-01

The Quality of Work life (QWL) is the employees' feeling or perception of being comfortable with their work. The objective of the present study was to compare Quality of School Work Life (QSWL) of public school teachers from Turkey and Pakistan. A QSWL scale developed by Ilgan, Ata, Zepeda and Ozu-Cengiz (2014) having 30 items was used as the…

Pathophysiology of spontaneous venous gas embolism

NASA Technical Reports Server (NTRS)

Lambertsen, C. J.; Albertine, K. H.; Pisarello, J. B.; Flores, N. D.

1991-01-01

The use of controllable degrees and durations of continuous isobaric counterdiffusion venous gas embolism to investigate effects of venous gas embolism upon blood, cardiovascular, and respiratory gas exchange function, as well as pathological effects upon the lung and its microcirculation is discussed. Use of N2O/He counterdiffusion permitted performance of the pathophysiologic and pulmonary microstructural effects at one ATA without hyperbaric or hypobaric exposures.

School Fights: Resisting Oppression in the Classroom in Gloria Velásquez's Latina/o Young Adult Novel "Juanita Fights the School Board"

ERIC Educational Resources Information Center

Rodríguez, Sonia Alejandra

2018-01-01

There is a long history of discrimination and marginalization of Chicanas/Latinas in the classroom due to xenophobia, language barriers, citizenship status, oversexualization, and much more. Through an analysis of Gloria Velasquez's ("Juanita Fights the School Board," Piñata Books, Houston, 1995) I seek to demonstrate the ways in which…

Improved Operational Readiness through Environmental Stress Screening

DTIC Science & Technology

1987-11-01

Rhoades of Gru-,.:an’s Field Marketing Department, and the cooperation of the ni- merous Air Force logistics centers and operational facilities visited...EQUIPMENT AGE * ENVIRONMENTAL MAINTENANCE EFFECT PROFILES DtATA * TAILORING DEFINTION MET HOD1OLOGY I 1GUIDELINE oi FIELD ESS IMPLEMENTATION GUIDELINW...any mixing or mismatching appeared, the data was eliminated completely. Figure 5 provides the annual historical trends of each case history equipment

The Major Crimes Task Force-Afghanistan: A Case Study and Examination of Implications for Future FBI Capacity Building Programs

DTIC Science & Technology

2014-12-01

senior leadership ATA Anti -Terrorism Assistance BG Brigadier General CIA Central Intelligence Agency CID criminal investigative division...authorizes the use of wiretapping evidence only in crimes involving narco-trafficking or money laundering . While the AG’s office originally signed 134...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited THE MAJOR CRIMES

Controlled Evaluation of the Effects of Hyperbaric Oxygen Therapy on the Behavior of 16 Children with Autism Spectrum Disorders

ERIC Educational Resources Information Center

Jepson, Bryan; Granpeesheh, Doreen; Tarbox, Jonathan; Olive, Melissa L.; Stott, Carol; Braud, Scott; Yoo, J. Helen; Wakefield, Andrew; Allen, Michael S.

2011-01-01

Hyperbaric oxygen therapy (HBOT) has been used to treat individuals with autism. However, few studies of its effectiveness have been completed. The current study examined the effects of 40 HBOT sessions at 24% oxygen at 1.3 ATA on 11 topographies of directly observed behavior. Five replications of multiple baselines were completed across a total…

Brain Potentials and Personality: A New Look at Stress Susceptibility.

DTIC Science & Technology

1987-09-01

disinhibition (Dis) measures a hedonistic , extraverted lifestyle including drinking, parties, sex, and gambling; boredom susceptibility (BS) indicates an...adventure seeking; ES = Experience seeking; Dis = Disinhibition; BS = Boredom susceptibility. 1 14 I N i*5’ Table 4 Correlation of Auditory Evoked...20. aTAS = Thrill and adventure seeking; ES = Experience seeking; Dis = Disinhibition; BS = Boredom susceptibility. < .05. 15 I The present study

Translations on USSR Military Affairs No. 1369

DTIC Science & Technology

1978-08-09

in brackets [] are’ supplied by JPRS. Processing indicators such as [ Text ] or [Excerpt] in the first line of each item, or following the last line...Moscow,KRASNAYA ZVEZDA in Russian 1 Mar 78 p 4 [Article: "Military Political Schools"] [ Text ] Rizhskoye vyssheye voyenno-politicheskoye...34] [ Text ] Alma-Atinskoye vyssheye obshchevoyskovoye komandnoye uchilishche imeni Marshala Sovetskogo Soyuza I. S. Koneva (480094, g. Alma-Ata, 94

40 CFR 1054.305 - How must I prepare and test my production-line engines?

Code of Federal Regulations, 2011 CFR

2011-07-01

... way that represents the assembly procedures for other engines in the engine family. You must ask us to approve any deviations from your normal assembly procedures for other production engines in the engine family. (a) Test procedures. Test your production-line engines using the applicable testing procedures in...

40 CFR 1054.305 - How must I prepare and test my production-line engines?

Code of Federal Regulations, 2013 CFR

2013-07-01

... way that represents the assembly procedures for other engines in the engine family. You must ask us to approve any deviations from your normal assembly procedures for other production engines in the engine family. (a) Test procedures. Test your production-line engines using the applicable testing procedures in...

40 CFR 1054.305 - How must I prepare and test my production-line engines?

Code of Federal Regulations, 2010 CFR

2010-07-01

... way that represents the assembly procedures for other engines in the engine family. You must ask us to approve any deviations from your normal assembly procedures for other production engines in the engine family. (a) Test procedures. Test your production-line engines using the applicable testing procedures in...

40 CFR 1054.305 - How must I prepare and test my production-line engines?

Code of Federal Regulations, 2014 CFR

2014-07-01

... way that represents the assembly procedures for other engines in the engine family. You must ask us to approve any deviations from your normal assembly procedures for other production engines in the engine family. (a) Test procedures. Test your production-line engines using the applicable testing procedures in...

40 CFR 1054.305 - How must I prepare and test my production-line engines?

Code of Federal Regulations, 2012 CFR

2012-07-01

... way that represents the assembly procedures for other engines in the engine family. You must ask us to approve any deviations from your normal assembly procedures for other production engines in the engine family. (a) Test procedures. Test your production-line engines using the applicable testing procedures in...

Observed-Score Equating as a Test Assembly Problem.

ERIC Educational Resources Information Center

van der Linden, Wim J.; Luecht, Richard M.

1998-01-01

Derives a set of linear conditions of item-response functions that guarantees identical observed-score distributions on two test forms. The conditions can be added as constraints to a linear programming model for test assembly. An example illustrates the use of the model for an item pool from the Law School Admissions Test (LSAT). (SLD)

Computer Assisted Assembly of Tests at Educational Testing Service.

ERIC Educational Resources Information Center

Educational Testing Service, Princeton, NJ.

Two basic requirements for the successful initiation of a program for test assembly are the development of detailed item content classification systems and the delineation of the professional judgements made in building a test from a pool of items to detailed content, ability, and statistical specifications in terms precise enough to be translated…

Integrated Advanced Microwave Sounding Unit-A (AMSU-A). Performance Verification Report: METSAT Phase Locked Oscillator Assembly, P/N 1334360-1, S/N's F03 and F04

NASA Technical Reports Server (NTRS)

Pines, D.

1998-01-01

Two Flight Model AMSU-A Phase Locked Oscillators (P/N 1348360-1, S/Ns F03 and F04) have been tested per AES Test Procedure AE-26758. The tests included vibration testing, thermal cycle testing, AM/FM Noise testing, and full functional testing. EMI/REO 2 Testing was not performed. (See test data for S/N F01). Both AMSU-A Phase Locked Oscillators satisfactorily passed all performance requirements of the AE-26633 Product specification. During thermal cycling of PLO serial number F03, the oven and data logger momentarily lost power, including a loss of data. The unit did not experience any thermal stress. TAR 003134 describes the corrective action. Prior to testing PLO serial number FO4, power was applied to the unit. (+15v,-15v) the unit did not display the proper phase lock. Upon test equipment check out a connector was found to be defective. TAR 003133 describes the corrective action. After completion of testing of PLO serial number F04 was installed into Receiver Assembly F02. Upon testing F02 Receiver Assembly the unit was found not to phase lock at ambient temperature. Removal of PLO Assembly F04 was required. R2 was the real issue. Solithane was secondary. Troubleshooting revealed excessive solithane on inner PLL Assembly cover inhibiting optimum grounding. Also, R2 was reselected which increased the lock range from -30 C to +60 C. TAR 002737 describes the corrective action.

AN ITALIAN SURVEY OF COMPLIANCE WITH MAJOR GUIDELINES FOR L-THYROXINE OF PRIMARY HYPOTHYROIDISM.

PubMed

Vezzani, Silvia; Giannetta, Elisa; Altieri, Barbara; Barbonetti, Arcangelo; Bellastella, Giuseppe; Certo, Rosaria; Cignarelli, Angelo; Cinti, Francesca; D'Andrea, Settimio; Di Dalmazi, Giulia; Frara, Stefano; Garelli, Silvia; Giuffrida, Giuseppe; Maiorino, Maria Ida; Mele, Chiara; Mezza, Teresa; Pani, Maria Grazia; Samà, Maria Teresa; Satta, Chiara; Santi, Daniele

2018-05-01

The adherence by endocrinologists to guideline regarding levothyroxine (LT4) therapy and the compliance of patients may impact the management of hypothyroidism. The aim of this study was to compare the adherence of Italian endocrinologists to the ATA/AACE and ETA guidelines on the management of newly diagnosed primary hypothyroidism and to validate the Italian version of the Morisky-Green Medical Adherence Scale-8 (MMAS-8) questionnaire as applied to the evaluation of the adherence of patients with hypothyroidism to LT4 treatment. This was an observational, longitudinal, multicenter, cohort study, involving 12 Italian Units of Endocrinology. The study enrolled 1,039 consecutive outpatients (mean age 48 years; 855 women, 184 men). The concordance of Italian endocrinologists with American Association of Clinical Endocrinologists/American Thyroid Association (AACE/ATA) and European Thyroid Association (ETA) recommendations was comparable (77.1% and 71.7%) and increased (86.7 and 88.6%) after the recommendations on LT4 dose were excluded, considering only the remaining recommendations on diagnosis, therapy, and follow-up. The MMAS-8 was filled out by 293 patients. The mean score was 6.71 with 23.9% low (score <6), 38.6% medium (6 to <8), 37.5% highly (= 8) adherers; the internal validation coefficient was 0.613. Highly adherent patients were not more likely to have good control of hypothyroidism compared with either medium (69% versus 72%, P = .878) or low (69% versus 43%, P = .861) adherers. Clinical management of hypothyroidism in Italy demonstrated an observance of international guidelines by Italian endocrinologists. Validation of the Italian version of the MMAS-8 questionnaire provides clinicians with a reliable and simple tool for assessing the adherence of patients to LT4 treatment. AACE = American Association of Clinical Endocrinologists; ATA = American Thyroid Association; EDIPO = Endotrial SIE: DIagnosis and clinical management of Primitive hypothyrOidism in Italy; eCRF = electronic case report form; ETA = European Thyroid Association; fT3 = free triiodothyronine; fT4 = free thyroxine; LT4 = levothyroxine; MMAS-8 = Morisky-Green Medical Adherence Scale-8; PH = primary hypothyroidism; T3 = triiodothyronine; T4 = thyroxine; TSH = thyroid-stimulating hormone; US = ultrasonography.

[Primary health care and the millennium development goals].

PubMed

Faye, A; Bob, M; Fall, A; Fall, C

2012-01-01

Member countries of the World Health Organization (WHO) met in Alma Ata (8-12 September 1978) to define and advocate the implementation of primary health care (PHC) worldwide, above all, in developing countries, which had a real need to review their strategies for meeting the health needs of their populations. They did not suspect that 20 years later the vision they displayed would remain undeniably relevant. Here we examine the similarities and points of convergence of their declaration about PHC with the Millennium Development Goals that seek today to reduce poverty across the world. An exhaustive and analytic literature review was conducted to collect those similarities. Further analysis of the definitions, objectives, principles and recommendations of the Alma Ata Declaration and the Millennium Declaration reveals multiple dependencies and fundamental points of similarity between these two representations. Almost all states have pledged to achieve the eight MDG by 2015: to eradicate extreme poverty and hunger, achieve universal primary education, promote gender equality and empower women, reduce child mortality, improve maternal health, combat HIV/AIDS, malaria and other diseases, ensure environmental sustainability, and develop a global partnership for development. The Alma Ata conference defined primary health care as essential health care, based on practical methods and techniques that are both scientifically sound and socially acceptable, universally accessible to all individuals and all families of the community, through their full participation and at a cost that the community and countries can afford at all stages of their development in the spirit of self-reliance and self-determination. It is an integral part of economic and social development. The following principles are involved in the achievement of both primary health care and the MDG: social equity, community participation, and intersectorality. Public health is an essential condition of poverty eradication and MDG achievement. Public health issues are central to the problem of sustainable development and must therefore remain the focus of attention. It is increasingly urgent to break the vicious circle created by the close correlation between environmental degradation, poor health, and poverty.

49 CFR 572.5 - General description.

Code of Federal Regulations, 2010 CFR

2010-10-01

... M080—Right leg assembly SA 150 M081—Left leg assembly SA 150 M010—Head assembly SA 150 M020—Neck... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) ANTHROPOMORPHIC TEST DEVICES 50th Percentile Male § 572... grouped by component assemblies under the following nine headings: SA 150 M070—Right arm assembly SA 150...

Cryogenic Fiber Optic Assemblies for Spaceflight Environments: Design, Manufacturing, Testing, and Integration

NASA Technical Reports Server (NTRS)

Thomes, W. Joe; Ott, Melanie N.; Chuska, Richard; Switzer, Robert; Onuma, Eleanya; Blair, Diana; Frese, Erich; Matyseck, Marc

2016-01-01

Fiber optic assemblies have been used on spaceflight missions for many years as an enabling technology for routing, transmitting, and detecting optical signals. Due to the overwhelming success of NASA in implementing fiber optic assemblies on spaceflight science-based instruments, system scientists increasingly request fibers that perform in extreme environments while still maintaining very high optical transmission, stability, and reliability. Many new applications require fiber optic assemblies that will operate down to cryogenic temperatures as low as 20 Kelvin. In order for the fiber assemblies to operate with little loss in optical throughput at these extreme temperatures requires a system level approach all the way from how the fiber assembly is manufactured to how it is held, routed, and integrated. The NASA Goddard Code 562 Photonics Group has been designing, manufacturing, testing, and integrating fiber optics for spaceflight and other high reliability applications for nearly 20 years. Design techniques and lessons learned over the years are consistently applied to developing new fiber optic assemblies that meet these demanding environments. System level trades, fiber assembly design methods, manufacturing, testing, and integration will be discussed. Specific recent examples of ground support equipment for the James Webb Space Telescope (JWST); the Ice, Cloud and Land Elevation Satellite-2 (ICESat-2); and others will be included.

Cryogenic fiber optic assemblies for spaceflight environments: design, manufacturing, testing, and integration

NASA Astrophysics Data System (ADS)

Thomes, W. Joe; Ott, Melanie N.; Chuska, Richard; Switzer, Robert; Onuma, Eleanya; Blair, Diana; Frese, Erich; Matyseck, Marc

2016-09-01

Fiber optic assemblies have been used on spaceflight missions for many years as an enabling technology for routing, transmitting, and detecting optical signals. Due to the overwhelming success of NASA in implementing fiber optic assemblies on spaceflight science-based instruments, system scientists increasingly request fibers that perform in extreme environments while still maintaining very high optical transmission, stability, and reliability. Many new applications require fiber optic assemblies that will operate down to cryogenic temperatures as low as 20 Kelvin. In order for the fiber assemblies to operate with little loss in optical throughput at these extreme temperatures requires a system level approach all the way from how the fiber assembly is manufactured to how it is held, routed, and integrated. The NASA Goddard Code 562 Photonics Group has been designing, manufacturing, testing, and integrating fiber optics for spaceflight and other high reliability applications for nearly 20 years. Design techniques and lessons learned over the years are consistently applied to developing new fiber optic assemblies that meet these demanding environments. System level trades, fiber assembly design methods, manufacturing, testing, and integration will be discussed. Specific recent examples of ground support equipment for the James Webb Space Telescope (JWST); the Ice, Cloud and Land Elevation Satellite-2 (ICESat- 2); and others will be included.

14 CFR 33.88 - Engine overtemperature test.

Code of Federal Regulations, 2011 CFR

2011-01-01

... AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Block Tests; Turbine Aircraft Engines § 33.88 Engine overtemperature... this run, the turbine assembly must be within serviceable limits. (b) In addition to the test... this run, the turbine assembly may exhibit distress beyond the limits for an overtemperature condition...

14 CFR 33.88 - Engine overtemperature test.

Code of Federal Regulations, 2013 CFR

2013-01-01

... AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Block Tests; Turbine Aircraft Engines § 33.88 Engine overtemperature... this run, the turbine assembly must be within serviceable limits. (b) In addition to the test... this run, the turbine assembly may exhibit distress beyond the limits for an overtemperature condition...

14 CFR 33.88 - Engine overtemperature test.

Code of Federal Regulations, 2014 CFR

2014-01-01

... AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Block Tests; Turbine Aircraft Engines § 33.88 Engine overtemperature... this run, the turbine assembly must be within serviceable limits. (b) In addition to the test... this run, the turbine assembly may exhibit distress beyond the limits for an overtemperature condition...

Fabrication Control Plan for ORNL RH-LOCA ATF Test Specimens to be Irradiated in the ATR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Field, Kevin G.; Howard, Richard; Teague, Michael

2014-06-01

The purpose of this fabrication plan is (1) to summarize the design of a set of rodlets that will be fabricated and then irradiated in the Advanced Test Reactor (ATR) and (2) provide requirements for fabrication and acceptance criteria for inspections of the Light Water Reactor (LWR) – Accident Tolerant Fuels (ATF) rodlet components. The functional and operational (F&OR) requirements for the ATF program are identified in the ATF Test Plan. The scope of this document only covers fabrication and inspections of rodlet components detailed in drawings 604496 and 604497. It does not cover the assembly of these items tomore » form a completed test irradiation assembly or the inspection of the final assembly, which will be included in a separate INL final test assembly specification/inspection document. The controls support the requirements that the test irradiations must be performed safely and that subsequent examinations must provide valid results.« less

SP-100 GES/NAT radiation shielding systems design and development testing

NASA Astrophysics Data System (ADS)

Disney, Richard K.; Kulikowski, Henry D.; McGinnis, Cynthia A.; Reese, James C.; Thomas, Kevin; Wiltshire, Frank

1991-01-01

Advanced Energy Systems (AES) of Westinghouse Electric Corporation is under subcontract to the General Electric Company to supply nuclear radiation shielding components for the SP-100 Ground Engineering System (GES) Nuclear Assembly Test to be conducted at Westinghouse Hanford Company at Richland, Washington. The radiation shielding components are integral to the Nuclear Assembly Test (NAT) assembly and include prototypic and non-prototypic radiation shielding components which provide prototypic test conditions for the SP-100 reactor subsystem and reactor control subsystem components during the GES/NAT operations. W-AES is designing three radiation shield components for the NAT assembly; a prototypic Generic Flight System (GFS) shield, the Lower Internal Facility Shield (LIFS), and the Upper Internal Facility Shield (UIFS). This paper describes the design approach and development testing to support the design, fabrication, and assembly of these three shield components for use within the vacuum vessel of the GES/NAT. The GES/NAT shields must be designed to operate in a high vacuum which simulates space operations. The GFS shield and LIFS must provide prototypic radiation/thermal environments and mechanical interfaces for reactor system components. The NAT shields, in combination with the test facility shielding, must provide adequate radiation attenuation for overall test operations. Special design considerations account for the ground test facility effects on the prototypic GFS shield. Validation of the GFS shield design and performance will be based on detailed Monte Carlo analyses and developmental testing of design features. Full scale prototype testing of the shield subsystems is not planned.

Solving Infeasibility Problems in Computerized Test Assembly.

ERIC Educational Resources Information Center

Timminga, Ellen

1998-01-01

Discusses problems of diagnosing and repairing infeasible linear-programming models in computerized test assembly. Demonstrates that it is possible to localize the causes of infeasibility, although this is not always easy. (SLD)

The MARVEL assembly for neutron multiplication.

PubMed

Chichester, David L; Kinlaw, Mathew T

2013-10-01

A new multiplying test assembly is under development at Idaho National Laboratory to support research, validation, evaluation, and learning. The item is comprised of three stacked, highly-enriched uranium (HEU) cylinders, each 11.4 cm in diameter and having a combined height of up to 11.7 cm. The combined mass of all three cylinders is 20.3 kg of HEU. Calculations for the bare configuration of the assembly indicate a multiplication level of >3.5 (k(eff)=0.72). Reflected configurations of the assembly, using either polyethylene or tungsten, are possible and have the capability of raising the assembly's multiplication level to greater than 10. This paper describes simulations performed to assess the assembly's multiplication level under different conditions and describes the resources available at INL to support the use of these materials. We also describe some preliminary calculations and test activities using the assembly to study neutron multiplication. Copyright © 2013 Elsevier Ltd. All rights reserved.

Payload spin assembly for the commercial Titan launch vehicle

NASA Technical Reports Server (NTRS)

Robinson, Wilf; Pech, Greg

1991-01-01

A contract was completed to design, build, and test a Payload Spin Assembly (PSA) for installation onto the Martin Marietta Titan 3 Commercial launch vehicle. This assembly provides launch support for satellite payloads up to 5783 kilograms (6.37 tons) and controls release, spin-up, and final separation of the satellite from the second stage. Once separated, the satellite's Perigee Kick Motor (PKM) boosts the satellite into its transfer orbit. The first successful flight occurred December 31, 1989. Requirements, design, test, and problems associated with this mechanical assembly are discussed.

LPT. Shield test facility assembly and test building (TAN646), south ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

LPT. Shield test facility assembly and test building (TAN-646), south end of EBOR helium wing. Camera facing north. Monorail protrudes from upper-level door. Rust marks on concrete wall are from stack. Metal shed is post-1970 addition. INEEL negative no. HD-40-8-1 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

Analysis of space environment damage to solar cell assemblies from LDEF experiment A0171-GSFC test plate

NASA Technical Reports Server (NTRS)

Hill, David C.; Rose, M. Frank

1994-01-01

The results of the postflight analysis of the solar cell assemblies from the LDEF (Long Duration Exposure facility) experiment A0171 is provided in this NASA sponsored research project. The following data on this research are provided as follows: (1) solar cell description, including, substrate composition and thickness, crystal orientation, anti-reflective coating composition and thickness; (2) preflight characteristics of the solar cell assemblies with respect to current and voltage; and (3) post-flight characteristics of the solar cell assemblies with respect to voltage and current. These solar cell assemblies are part of the Goddard Space Flight Center test plate which was designed to test the space environment effects (radiation, atomic oxygen, thermal cycling, meteoroid and debris) on conductively coated solar cell coversheets, various electrical bond materials, solar cell performance, and other material properties where feasible.

An expert system executive for automated assembly of large space truss structures

NASA Technical Reports Server (NTRS)

Allen, Cheryl L.

1993-01-01

Langley Research Center developed a unique test bed for investigating the practical problems associated with the assembly of large space truss structures using robotic manipulators. The test bed is the result of an interdisciplinary effort that encompasses the full spectrum of assembly problems - from the design of mechanisms to the development of software. The automated structures assembly test bed and its operation are described, the expert system executive and its development are detailed, and the planned system evolution is discussed. Emphasis is on the expert system implementation of the program executive. The executive program must direct and reliably perform complex assembly tasks with the flexibility to recover from realistic system errors. The employment of an expert system permits information that pertains to the operation of the system to be encapsulated concisely within a knowledge base. This consolidation substantially reduced code, increased flexibility, eased software upgrades, and realized a savings in software maintenance costs.

78 FR 45104 - Model Manufactured Home Installation Standards: Ground Anchor Installations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-26

... test methods for establishing working load design values of ground anchor assemblies used for new... anchor installations and establish standardized test methods to determine ground anchor performance and... currently no national test method for rating and certifying ground anchor assemblies in different soil...

LPT. Low power assembly and test building (TAN640). Camera facing ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

LPT. Low power assembly and test building (TAN-640). Camera facing west. Rollup doors to each test cell face east. Concrete walls poured in place. Apparatus at right of view was part of a post-ANP program. INEEL negative no. HD-40-1-1 - Idaho National Engineering Laboratory, Test Area North, Scoville, Butte County, ID

Status of the eROSITA Telescope testing and calibrating the x-ray mirror assemblies

NASA Astrophysics Data System (ADS)

Burwitz, Vadim; Predehl, Peter; Bräuninger, Heinrich; Burkert, Wolfgang; Dennerl, Konrad; Eder, Josef; Friedrich, Peter; Fürmetz, Maria; Grisoni, Gabriele; Hartner, Gisela; Marioni, Fabio; Menz, Benedikt; Pfeffermann, Elmar; Valsecchi, Giuseppe

2013-09-01

The eROSITA X-ray observatory that will be launched on board the Russian Spectrum-RG mission comprises seven X-ray telescopes, each with its own mirror assembly (mirror module + X-ray baffle), electron deflector, filter wheel, and CCD camera with its control electronics. The completed flight mirror modules are undergoing many thorough X-ray tests at the PANTHER X-ray test facility after delivery, after being mated with the X-ray baffle, and again after both the vibration and thermal-vacuum tests. A description of the work done with mirror modules/assemblies and the test results obtained will be reported here. We report also on the environmental tests that have been performed on the eROSITA telescope qualification model.

Development Status of the Fission Power System Technology Demonstration Unit

NASA Technical Reports Server (NTRS)

Briggs, Maxwell H.; Gibson, Marc A.; Geng, Steven M.; Pearson, Jon Boise; Godfoy, Thomas

2012-01-01

This paper summarizes the progress that has been made in the development of the Fission Power System Technology Demonstration Unit (TDU). The reactor simulator core and Annular Linear Induction Pump have been fabricated and assembled into a test loop at the NASA Marshall Space Flight Center. A 12 kWe Power Conversion Unit (PCU) is being developed consisting of two 6 kWe free-piston Stirling engines. The two 6 kWe engines have been fabricated by Sunpower Inc. and are currently being tested separately prior to integration into the PCU. The Facility Cooling System (FCS) used to reject convertor waste heat has been assembled and tested at the NASA Glenn Research Center (GRC). The structural elements, including a Buildup Assembly Platform (BAP) and Upper Truss Structure (UTS) have been fabricated, and will be used to test cold-end components in thermal vacuum prior to TDU testing. Once all components have been fully tested at the subsystem level, they will be assembled into an end-to-end system and tested in thermal vacuum at GRC.

Base excitation testing system using spring elements to pivotally mount wind turbine blades

DOEpatents

Cotrell, Jason; Hughes, Scott; Butterfield, Sandy; Lambert, Scott

2013-12-10

A system (1100) for fatigue testing wind turbine blades (1102) through forced or resonant excitation of the base (1104) of a blade (1102). The system (1100) includes a test stand (1112) and a restoring spring assembly (1120) mounted on the test stand (1112). The restoring spring assembly (1120) includes a primary spring element (1124) that extends outward from the test stand (1112) to a blade mounting plate (1130) configured to receive a base (1104) of blade (1102). During fatigue testing, a supported base (1104) of a blad (1102) may be pivotally mounted to the test stand (1112) via the restoring spring assembly (1120). The system (1100) may include an excitation input assembly (1140) that is interconnected with the blade mouting plate (1130) to selectively apply flapwise, edgewise, and/or pitch excitation forces. The restoring spring assemply (1120) may include at least one tuning spring member (1127) positioned adjacent to the primary spring element (1124) used to tune the spring constant or stiffness of the primary spring element (1124) in one of the excitation directions.