Variable speed gas engine-driven air compressor system

NASA Astrophysics Data System (ADS)

Morgan, J. R.; Ruggles, A. E.; Chen, T. N.; Gehret, J.

1992-11-01

Tecogen Inc. and Ingersoll-Rand Co. as a subcontractor have designed a nominal 150-hp gas engine-driven air compressor utilizing the TECODRIVE 8000 engine and the Ingersoll-Rand 178.5-mm twin screw compressor. Phase 1 included the system engineering and design, economic and applications studies, and a draft commercialization plan. Phase 2 included controls development, laboratory prototype construction, and performance testing. The testing conducted verified that the compressor meets all design specifications.

Development of Electric Power Units Driven by Waste Heat

NASA Astrophysics Data System (ADS)

Inoue, Naoyuki; Takeuchi, Takao; Kaneko, Atsushi; Uchimura, Tomoyuki; Irie, Kiichi; Watanabe, Hiroyoshi

For the development of a simple and compact power generator driven by waste heat, working fluids and an expander were studied, then a practical electric power unit was put to test. Many working fluids were calculated with the low temperature power cycle (evaporated at 77°C, condensed at 42°C),and TFE,R123,R245fa were selected to be suitable for the cycle. TFE(Trifluoroethanol CF3CH2OH) was adopted to the actual power generator which was tested. A radial turbine was adopted as an expander, and was newly designed and manufactured for working fluid TFE. The equipment was driven by hot water as heat source and cooling water as cooling source, and generated power was connected with electric utility. Characteristics of the power generating cycle and characteristics of the turbine were obtained experimentally.

SMART NAS Test Bed Overview

NASA Technical Reports Server (NTRS)

Palopo, Kee

2016-01-01

These slides presents an overview of SMART NAS Test Bed. The test bed is envisioned to be connected to operational systems and to allow a new concept and technology to be evaluated in its realistic environment. Its role as an accelerator of concepts and technologies development, its use-case-driven development approach, and its state are presented.

Data Driven Decision Making in the Social Studies

ERIC Educational Resources Information Center

Ediger, Marlow

2010-01-01

Data driven decision making emphasizes the importance of the teacher using objective sources of information in developing the social studies curriculum. Too frequently, decisions of teachers have been made based on routine and outdated methods of teaching. Valid and reliable tests used to secure results from pupil learning make for better…

RF Negative Ion Source Development at IPP Garching

NASA Astrophysics Data System (ADS)

Kraus, W.; McNeely, P.; Berger, M.; Christ-Koch, S.; Falter, H. D.; Fantz, U.; Franzen, P.; Fröschle, M.; Heinemann, B.; Leyer, S.; Riedl, R.; Speth, E.; Wünderlich, D.

2007-08-01

IPP Garching is heavily involved in the development of an ion source for Neutral Beam Heating of the ITER Tokamak. RF driven ion sources have been successfully developed and are in operation on the ASDEX-Upgrade Tokamak for positive ion based NBH by the NB Heating group at IPP Garching. Building on this experience a RF driven H- ion source has been under development at IPP Garching as an alternative to the ITER reference design ion source. The number of test beds devoted to source development for ITER has increased from one (BATMAN) by the addition of two test beds (MANITU, RADI). This paper contains descriptions of the three test beds. Results on diagnostic development using laser photodetachment and cavity ringdown spectroscopy are given for BATMAN. The latest results for long pulse development on MANITU are presented including the to date longest pulse (600 s). As well, details of source modifications necessitated for pulses in excess of 100 s are given. The newest test bed RADI is still being commissioned and only technical details of the test bed are included in this paper. The final topic of the paper is an investigation into the effects of biasing the plasma grid.

Designing an optimal software intensive system acquisition: A game theoretic approach

NASA Astrophysics Data System (ADS)

Buettner, Douglas John

The development of schedule-constrained software-intensive space systems is challenging. Case study data from national security space programs developed at the U.S. Air Force Space and Missile Systems Center (USAF SMC) provide evidence of the strong desire by contractors to skip or severely reduce software development design and early defect detection methods in these schedule-constrained environments. The research findings suggest recommendations to fully address these issues at numerous levels. However, the observations lead us to investigate modeling and theoretical methods to fundamentally understand what motivated this behavior in the first place. As a result, Madachy's inspection-based system dynamics model is modified to include unit testing and an integration test feedback loop. This Modified Madachy Model (MMM) is used as a tool to investigate the consequences of this behavior on the observed defect dynamics for two remarkably different case study software projects. Latin Hypercube sampling of the MMM with sample distributions for quality, schedule and cost-driven strategies demonstrate that the higher cost and effort quality-driven strategies provide consistently better schedule performance than the schedule-driven up-front effort-reduction strategies. Game theory reasoning for schedule-driven engineers cutting corners on inspections and unit testing is based on the case study evidence and Austin's agency model to describe the observed phenomena. Game theory concepts are then used to argue that the source of the problem and hence the solution to developers cutting corners on quality for schedule-driven system acquisitions ultimately lies with the government. The game theory arguments also lead to the suggestion that the use of a multi-player dynamic Nash bargaining game provides a solution for our observed lack of quality game between the government (the acquirer) and "large-corporation" software developers. A note is provided that argues this multi-player dynamic Nash bargaining game also provides the solution to Freeman Dyson's problem, for a way to place a label of good or bad on systems.

Joint Loads and Cartilage Stress in Intact Joints of Military Transtibial Amputees: Enhancing Quality of Life

DTIC Science & Technology

2017-04-01

crosstalk); analysis of tested subjects underway. 4) Developed analytical methods to obtain knee joint loads using EMG-driven inverse dynamics; analysis of...13/2018. Completion %: 40. Task 1.3: EMG-driven inverse dynamic (ID) analyses with OpenSim for amputee and control group subjects. Target date: 1...predicted by EMG-driven inverse dynamics. Two-three conference papers are being prepared for submission in February 2017. Other achievements. None

The Impact of Data-Based Science Instruction on Standardized Test Performance

NASA Astrophysics Data System (ADS)

Herrington, Tia W.

Increased teacher accountability efforts have resulted in the use of data to improve student achievement. This study addressed teachers' inconsistent use of data-driven instruction in middle school science. Evidence of the impact of data-based instruction on student achievement and school and district practices has been well documented by researchers. In science, less information has been available on teachers' use of data for classroom instruction. Drawing on data-driven decision making theory, the purpose of this study was to examine whether data-based instruction impacted performance on the science Criterion Referenced Competency Test (CRCT) and to explore the factors that impeded its use by a purposeful sample of 12 science teachers at a data-driven school. The research questions addressed in this study included understanding: (a) the association between student performance on the science portion of the CRCT and data-driven instruction professional development, (b) middle school science teachers' perception of the usefulness of data, and (c) the factors that hindered the use of data for science instruction. This study employed a mixed methods sequential explanatory design. Data collected included 8th grade CRCT data, survey responses, and individual teacher interviews. A chi-square test revealed no improvement in the CRCT scores following the implementation of professional development on data-driven instruction (chi 2 (1) = .183, p = .67). Results from surveys and interviews revealed that teachers used data to inform their instruction, indicating time as the major hindrance to their use. Implications for social change include the development of lesson plans that will empower science teachers to deliver data-based instruction and students to achieve identified academic goals.

A cable-driven locomotor training system for restoration of gait in human SCI.

PubMed

Wu, Ming; Hornby, T George; Landry, Jill M; Roth, Heidi; Schmit, Brian D

2011-02-01

A novel cable-driven robotic locomotor training system was developed to provide compliant assistance/resistance forces to the legs during treadmill training in patients with incomplete spinal cord injury (SCI). Eleven subjects with incomplete SCI were recruited to participate in two experiments to test the feasibility of the robotic gait training system. Specifically, 10 subjects participated in one experimental session to test the characteristics of the robotic gait training system and one subject participated in repeated testing sessions over 8 weeks with the robotic device to test improvements in locomotor function. Limb kinematics were recorded in one experiment to evaluate the system characteristics of the cable-driven locomotor trainer and the overground gait speed and 6 min walking distance were evaluated at pre, 4 and 8 weeks post treadmill training of a single subject as well. The results indicated that the cable driven robotic gait training system improved the kinematic performance of the leg during treadmill walking and had no significant impact on the variability of lower leg trajectory, suggesting a high backdrivability of the cable system. In addition, results from a patient with incomplete SCI indicated that prolonged robotic gait training using the cable robot improved overground gait speed. Results from this study suggested that a cable driven robotic gait training system is effective in improving leg kinematic performance, yet allows variability of gait kinematics. Thus, it seems feasible to improve the locomotor function in human SCI using this cable driven robotic system, warranting testing with a larger group of patients. Copyright © 2010 Elsevier B.V. All rights reserved.

An interactive ontology-driven information system for simulating background radiation and generating scenarios for testing special nuclear materials detection algorithms

DOE PAGES

Sorokine, Alexandre; Schlicher, Bob G.; Ward, Richard C.; ...

2015-05-22

This paper describes an original approach to generating scenarios for the purpose of testing the algorithms used to detect special nuclear materials (SNM) that incorporates the use of ontologies. Separating the signal of SNM from the background requires sophisticated algorithms. To assist in developing such algorithms, there is a need for scenarios that capture a very wide range of variables affecting the detection process, depending on the type of detector being used. To provide such a cpability, we developed an ontology-driven information system (ODIS) for generating scenarios that can be used in creating scenarios for testing of algorithms for SNMmore » detection. The ontology-driven scenario generator (ODSG) is an ODIS based on information supplied by subject matter experts and other documentation. The details of the creation of the ontology, the development of the ontology-driven information system, and the design of the web user interface (UI) are presented along with specific examples of scenarios generated using the ODSG. We demonstrate that the paradigm behind the ODSG is capable of addressing the problem of semantic complexity at both the user and developer levels. Compared to traditional approaches, an ODIS provides benefits such as faithful representation of the users' domain conceptualization, simplified management of very large and semantically diverse datasets, and the ability to handle frequent changes to the application and the UI. Furthermore, the approach makes possible the generation of a much larger number of specific scenarios based on limited user-supplied information« less

Data-Driven Learning of Speech Acts Based on Corpora of DVD Subtitles

ERIC Educational Resources Information Center

Kitao, S. Kathleen; Kitao, Kenji

2013-01-01

Data-driven learning (DDL) is an inductive approach to language learning in which students study examples of authentic language and use them to find patterns of language use. This inductive approach to learning has the advantages of being learner-centered, encouraging hypothesis testing and learner autonomy, and helping develop learning skills.…

The Depression Inventory Development Workgroup: A Collaborative, Empirically Driven Initiative to Develop a New Assessment Tool for Major Depressive Disorder.

PubMed

Vaccarino, Anthony L; Evans, Kenneth R; Kalali, Amir H; Kennedy, Sidney H; Engelhardt, Nina; Frey, Benicio N; Greist, John H; Kobak, Kenneth A; Lam, Raymond W; MacQueen, Glenda; Milev, Roumen; Placenza, Franca M; Ravindran, Arun V; Sheehan, David V; Sills, Terrence; Williams, Janet B W

2016-01-01

The Depression Inventory Development project is an initiative of the International Society for CNS Drug Development whose goal is to develop a comprehensive and psychometrically sound measurement tool to be utilized as a primary endpoint in clinical trials for major depressive disorder. Using an iterative process between field testing and psychometric analysis and drawing upon expertise of international researchers in depression, the Depression Inventory Development team has established an empirically driven and collaborative protocol for the creation of items to assess symptoms in major depressive disorder. Depression-relevant symptom clusters were identified based on expert clinical and patient input. In addition, as an aid for symptom identification and item construction, the psychometric properties of existing clinical scales (assessing depression and related indications) were evaluated using blinded datasets from pharmaceutical antidepressant drug trials. A series of field tests in patients with major depressive disorder provided the team with data to inform the iterative process of scale development. We report here an overview of the Depression Inventory Development initiative, including results of the third iteration of items assessing symptoms related to anhedonia, cognition, fatigue, general malaise, motivation, anxiety, negative thinking, pain and appetite. The strategies adopted from the Depression Inventory Development program, as an empirically driven and collaborative process for scale development, have provided the foundation to develop and validate measurement tools in other therapeutic areas as well.

Development and validation of a turbulent-mix model for variable-density and compressible flows.

PubMed

Banerjee, Arindam; Gore, Robert A; Andrews, Malcolm J

2010-10-01

The modeling of buoyancy driven turbulent flows is considered in conjunction with an advanced statistical turbulence model referred to as the BHR (Besnard-Harlow-Rauenzahn) k-S-a model. The BHR k-S-a model is focused on variable-density and compressible flows such as Rayleigh-Taylor (RT), Richtmyer-Meshkov (RM), and Kelvin-Helmholtz (KH) driven mixing. The BHR k-S-a turbulence mix model has been implemented in the RAGE hydro-code, and model constants are evaluated based on analytical self-similar solutions of the model equations. The results are then compared with a large test database available from experiments and direct numerical simulations (DNS) of RT, RM, and KH driven mixing. Furthermore, we describe research to understand how the BHR k-S-a turbulence model operates over a range of moderate to high Reynolds number buoyancy driven flows, with a goal of placing the modeling of buoyancy driven turbulent flows at the same level of development as that of single phase shear flows.

Varying execution discipline to increase performance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Campbell, P.L.; Maccabe, A.B.

1993-12-22

This research investigates the relationship between execution discipline and performance. The hypothesis has two parts: 1. Different execution disciplines exhibit different performance for different computations, and 2. These differences can be effectively predicted by heuristics. A machine model is developed that can vary its execution discipline. That is, the model can execute a given program using either the control-driven, data-driven or demand-driven execution discipline. This model is referred to as a ``variable-execution-discipline`` machine. The instruction set for the model is the Program Dependence Web (PDW). The first part of the hypothesis will be tested by simulating the execution of themore » machine model on a suite of computations, based on the Livermore Fortran Kernel (LFK) Test (a.k.a. the Livermore Loops), using all three execution disciplines. Heuristics are developed to predict relative performance. These heuristics predict (a) the execution time under each discipline for one iteration of each loop and (b) the number of iterations taken by that loop; then the heuristics use those predictions to develop a prediction for the execution of the entire loop. Similar calculations are performed for branch statements. The second part of the hypothesis will be tested by comparing the results of the simulated execution with the predictions produced by the heuristics. If the hypothesis is supported, then the door is open for the development of machines that can vary execution discipline to increase performance.« less

Revisiting the hypothesis-driven interview in a contemporary context.

PubMed

Holmes, Alex; Singh, Bruce; McColl, Geoff

2011-12-01

The "hypothesis-driven interview" was articulated by George Engel as a method of raising and testing hypotheses in the process of building a biopsychosocial formulation and determining the most likely diagnosis. This interview was a forerunner of the modern medical interview as well as the contemporary psychiatric assessment. The objective of this article is to describe the hypothesis-driven interview and to explore its relationship with the contemporary medical interview. The literature on the medical and hypothesis-driven interview was reviewed. Key features of each were identified. The hypothesis-driven interview shares much with the contemporary medical interview. In addition, it enhances the application of communication skills and allows the interviewer to develop a formulation during the course of the assessment. The hypothesis-driven interview is well suited to the aims of a contemporary psychiatric assessment.

Microwave Driven Actuators Power Allocation and Distribution

NASA Technical Reports Server (NTRS)

Forbes, Timothy; Song, Kyo D.

2000-01-01

Design, fabrication and test of a power allocation and distribution (PAD) network for microwave driven actuators is presented in this paper. Development of a circuit that would collect power from a rectenna array amplify and distribute the power to actuators was designed and fabricated for space application in an actuator array driven by a microwave. A P-SPICE model was constructed initially for data reduction purposes, and was followed by a working real-world model. A voltage up - converter (VUC) is used to amplify the voltage from the individual rectenna. The testing yielded a 26:1 voltage amplification ratio with input voltage at 9 volts and a measured output voltage 230VDC. Future work includes the miniaturization of the circuitry, the use of microwave remote control, and voltage amplification technology for each voltage source. The objective of this work is to develop a model system that will collect DC voltage from an array of rectenna and propagate the voltage to an array of actuators.

Flight Validation of a Metrics Driven L(sub 1) Adaptive Control

NASA Technical Reports Server (NTRS)

Dobrokhodov, Vladimir; Kitsios, Ioannis; Kaminer, Isaac; Jones, Kevin D.; Xargay, Enric; Hovakimyan, Naira; Cao, Chengyu; Lizarraga, Mariano I.; Gregory, Irene M.

2008-01-01

The paper addresses initial steps involved in the development and flight implementation of new metrics driven L1 adaptive flight control system. The work concentrates on (i) definition of appropriate control driven metrics that account for the control surface failures; (ii) tailoring recently developed L1 adaptive controller to the design of adaptive flight control systems that explicitly address these metrics in the presence of control surface failures and dynamic changes under adverse flight conditions; (iii) development of a flight control system for implementation of the resulting algorithms onboard of small UAV; and (iv) conducting a comprehensive flight test program that demonstrates performance of the developed adaptive control algorithms in the presence of failures. As the initial milestone the paper concentrates on the adaptive flight system setup and initial efforts addressing the ability of a commercial off-the-shelf AP with and without adaptive augmentation to recover from control surface failures.

Development of High-Gradient Dielectric Laser-Driven Particle Accelerator Structures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Byer, Robert L.

2013-11-07

The thrust of Stanford's program is to conduct research on high-gradient dielectric accelerator structures driven with high repetition-rate, tabletop infrared lasers. The close collaboration between Stanford and SLAC (Stanford Linear Accelerator Center) is critical to the success of this project, because it provides a unique environment where prototype dielectric accelerator structures can be rapidly fabricated and tested with a relativistic electron beam.

Content Standards: High Stakes Anti-Differentiation

ERIC Educational Resources Information Center

Schroeder-Davis, Stephen

2011-01-01

Currently, American schooling, driven by No Child Left Behind (NCLB) and standardized tests, emphasizes development of intelligence. Because of this, teachers must heavily emphasize acquisition of foundational information (facts) in lectures, assessments, and of course, time-consuming test preparation, at the expense of intellect, that…

Flight test evaluation of a method to determine the level flight performance propeller-driven aircraft

NASA Technical Reports Server (NTRS)

Cross, E. J., Jr.

1976-01-01

A procedure is developed for deriving the level flight drag and propulsive efficiency of propeller-driven aircraft. This is a method in which the overall drag of the aircraft is expressed in terms of the measured increment of power required to overcome a corresponding known increment of drag. The aircraft is flown in unaccelerated, straight and level flight, and thus includes the effects of the propeller drag and slipstream. Propeller efficiency and airplane drag are computed on the basis of data obtained during flight test and do not rely on the analytical calculations of inadequate theory.

Development and evaluation of pile "high strain dynamic test database" to improve driven capacity estimates : phase 1 report.

DOT National Transportation Integrated Search

2014-01-01

The Maine Department of Transportation (MaineDOT) has noted poor correlation between predicted pile resistances : calculated using commonly accepted design methods and measured pile resistance from dynamic pile load tests (also : referred to as high ...

Development and evaluation of pile "high strain dynamic test database" to improve driven capacity estimates : phase 2 report.

DOT National Transportation Integrated Search

2014-01-01

The Maine Department of Transportation (MaineDOT) has noted poor correlation between predicted pile resistances : calculated using commonly accepted design methods and measured pile resistance from dynamic pile load tests (also : referred to as high ...

HVEPS Scramjet-Driven MHD Power Demonstration Test Results (Preprint)

DTIC Science & Technology

2007-06-01

an outer annulus which provides the flow passage for the liquid NaK. Final fabrication and assembly of the seeding system was completed at UTRC as...ABSTRACT The Air Force sponsored Hypersonic Vehicle Electric Power System (HVEPS) program was a research program to develop scramjet driven...magnetohydrodynamic (MHD) power for an advanced high power, airborne electric power system . This program has been active for the past five years with various

Revisiting Statistical Aspects of Nuclear Material Accounting

DOE PAGES

Burr, T.; Hamada, M. S.

2013-01-01

Nuclear material accounting (NMA) is the only safeguards system whose benefits are routinely quantified. Process monitoring (PM) is another safeguards system that is increasingly used, and one challenge is how to quantify its benefit. This paper considers PM in the role of enabling frequent NMA, which is referred to as near-real-time accounting (NRTA). We quantify NRTA benefits using period-driven and data-driven testing. Period-driven testing makes a decision to alarm or not at fixed periods. Data-driven testing decides as the data arrives whether to alarm or continue testing. The difference between period-driven and datad-riven viewpoints is illustrated by using one-year andmore » two-year periods. For both one-year and two-year periods, period-driven NMA using once-per-year cumulative material unaccounted for (CUMUF) testing is compared to more frequent Shewhart and joint sequential cusum testing using either MUF or standardized, independently transformed MUF (SITMUF) data. We show that the data-driven viewpoint is appropriate for NRTA and that it can be used to compare safeguards effectiveness. In addition to providing period-driven and data-driven viewpoints, new features include assessing the impact of uncertainty in the estimated covariance matrix of the MUF sequence and the impact of both random and systematic measurement errors.« less

Improved understanding of geologic CO{sub 2} storage processes requires risk-driven field experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oldenburg, C.M.

2011-06-01

The need for risk-driven field experiments for CO{sub 2} geologic storage processes to complement ongoing pilot-scale demonstrations is discussed. These risk-driven field experiments would be aimed at understanding the circumstances under which things can go wrong with a CO{sub 2} capture and storage (CCS) project and cause it to fail, as distinguished from accomplishing this end using demonstration and industrial scale sites. Such risk-driven tests would complement risk-assessment efforts that have already been carried out by providing opportunities to validate risk models. In addition to experimenting with high-risk scenarios, these controlled field experiments could help validate monitoring approaches to improvemore » performance assessment and guide development of mitigation strategies.« less

An integrated development workflow for community-driven FOSS-projects using continuous integration tools

NASA Astrophysics Data System (ADS)

Bilke, Lars; Watanabe, Norihiro; Naumov, Dmitri; Kolditz, Olaf

2016-04-01

A complex software project in general with high standards regarding code quality requires automated tools to help developers in doing repetitive and tedious tasks such as compilation on different platforms and configurations, doing unit testing as well as end-to-end tests and generating distributable binaries and documentation. This is known as continuous integration (CI). A community-driven FOSS-project within the Earth Sciences benefits even more from CI as time and resources regarding software development are often limited. Therefore testing developed code on more than the developers PC is a task which is often neglected and where CI can be the solution. We developed an integrated workflow based on GitHub, Travis and Jenkins for the community project OpenGeoSys - a coupled multiphysics modeling and simulation package - allowing developers to concentrate on implementing new features in a tight feedback loop. Every interested developer/user can create a pull request containing source code modifications on the online collaboration platform GitHub. The modifications are checked (compilation, compiler warnings, memory leaks, undefined behaviors, unit tests, end-to-end tests, analyzing differences in simulation run results between changes etc.) from the CI system which automatically responds to the pull request or by email on success or failure with detailed reports eventually requesting to improve the modifications. Core team developers review the modifications and merge them into the main development line once they satisfy agreed standards. We aim for efficient data structures and algorithms, self-explaining code, comprehensive documentation and high test code coverage. This workflow keeps entry barriers to get involved into the project low and permits an agile development process concentrating on feature additions rather than software maintenance procedures.

High School Students' Topic Preferences and Oral Development in an English-Only Short-Term Intensive Language Program

ERIC Educational Resources Information Center

Hsieh, Hui-Chen

2016-01-01

Developing the ability to speak English is a daunting task that has long been omitted in a test-driven pedagogy context (Chang, 2011; Li, 2012a, 2012b; Chen & Tsai, 2012; Katchen, 1989, 1995). Since speaking is not tested for school admissions, most students are not motivated to learn it (Chang, 2011; Chen & Tsai, 2012). Now, globalization…

UWB Tracking Software Development

NASA Technical Reports Server (NTRS)

Gross, Julia; Arndt, Dickey; Ngo, Phong; Phan, Chau; Dusl, John; Ni, Jianjun; Rafford, Melinda

2006-01-01

An Ultra-Wideband (UWB) two-cluster Angle of Arrival (AOA) tracking prototype system is currently being developed and tested at NASA Johnson Space Center for space exploration applications. This talk discusses the software development efforts for this UWB two-cluster AOA tracking system. The role the software plays in this system is to take waveform data from two UWB radio receivers as an input, feed this input into an AOA tracking algorithm, and generate the target position as an output. The architecture of the software (Input/Output Interface and Algorithm Core) will be introduced in this talk. The development of this software has three phases. In Phase I, the software is mostly Matlab driven and calls C++ socket functions to provide the communication links to the radios. This is beneficial in the early stage when it is necessary to frequently test changes in the algorithm. Phase II of the development is to have the software mostly C++ driven and call a Matlab function for the AOA tracking algorithm. This is beneficial in order to send the tracking results to other systems and also to improve the tracking update rate of the system. The third phase is part of future work and is to have the software completely C++ driven with a graphics user interface. This software design enables the fine resolution tracking of the UWB two-cluster AOA tracking system.

Design, development and testing twin pulse tube cryocooler

NASA Astrophysics Data System (ADS)

Gour, Abhay Singh; Sagar, Pankaj; Karunanithi, R.

2017-09-01

The design and development of Twin Pulse Tube Cryocooler (TPTC) is presented. Both the coolers are driven by a single Linear Moving Magnet Synchronous Motor (LMMSM) with piston heads at both ends of the mover shaft. Magnetostatic analysis for flux line distribution was carried-out during design and development of LMMSM based pressure wave generator. Based on the performance of PWG, design of TPTC was carried out using Sage and Computational Fluid Dynamics (CFD) analysis. Detailed design, fabrication and testing of LMMSM, TPTC and their integration tests are presented in this paper.

Testing protocol for predicting driven pile behavior within pre-bored soil : research project capsule.

DOT National Transportation Integrated Search

2014-02-01

The objective of this project is to compile the state-of-the-art and best practice : results available on the subject of pre-bored piles and develop a research and : instrumentation testing plan for fi eld data collection and select multiple pile : d...

Over-time associations among parental self-efficacy, promotive parenting practices, and adolescents' externalizing behaviors.

PubMed

Glatz, Terese; Buchanan, Christy M

2015-06-01

Parental self-efficacy (PSE) is defined as parents' beliefs about their abilities to influence their children in a way that fosters their children's positive development. Research has shown links among PSE, parenting, and children's behavior (Jones & Prinz, 2005), but there are still questions concerning the associations over time. Theory predicts 3 types of processes relevant to these associations: a PSE-driven process, a parent-behavior-driven process, and a child-driven process. In this study, we tested these processes during early to middle adolescence using reports from 401 parents (286 mothers, 115 fathers) from 305 families, and their adolescents (Mage = 11.5 years), at 3 time points. Cross-lagged panel models were used to examine the associations among PSE, promotive parenting practices, and adolescents' externalizing. Results supported a PSE-driven process for mothers within early adolescence. In addition, evidence for parent-behavior-driven and child-driven processes emerged at different times within this developmental period. (c) 2015 APA, all rights reserved).

Alternative Water Processor Test Development

NASA Technical Reports Server (NTRS)

Pickering, Karen D.; Mitchell, Julie L.; Adam, Niklas M.; Barta, Daniel; Meyer, Caitlin E.; Pensinger, Stuart; Vega, Leticia M.; Callahan, Michael R.; Flynn, Michael; Wheeler, Ray;

Alternative Water Processor Test Development

NASA Technical Reports Server (NTRS)

Pickering, Karen D.; Mitchell, Julie; Vega, Leticia; Adam, Niklas; Flynn, Michael; Wjee (er. Rau); Lunn, Griffin; Jackson, Andrew

2012-01-01

The Next Generation Life Support Project is developing an Alternative Water Processor (AWP) as a candidate water recovery system for long duration exploration missions. The AWP consists of biological water processor (BWP) integrated with a forward osmosis secondary treatment system (FOST). The basis of the BWP is a membrane aerated biological reactor (MABR), developed in concert with Texas Tech University. Bacteria located within the MABR metabolize organic material in wastewater, converting approximately 90% of the total organic carbon to carbon dioxide. In addition, bacteria convert a portion of the ammonia-nitrogen present in the wastewater to nitrogen gas, through a combination of nitrogen and denitrification. The effluent from the BWP system is low in organic contaminants, but high in total dissolved solids. The FOST system, integrated downstream of the BWP, removes dissolved solids through a combination of concentration-driven forward osmosis and pressure driven reverse osmosis. The integrated system is expected to produce water with a total organic carbon less than 50 mg/l and dissolved solids that meet potable water requirements for spaceflight. This paper describes the test definition, the design of the BWP and FOST subsystems, and plans for integrated testing.

Bottom-up approaches to strengthening child protection systems: Placing children, families, and communities at the center.

PubMed

Wessells, Michael G

2015-05-01

Efforts to strengthen national child protection systems have frequently taken a top-down approach of imposing formal, government-managed services. Such expert-driven approaches are often characterized by low use of formal services and the misalignment of the nonformal and formal aspects of the child protection system. This article examines an alternative approach of community-driven, bottom-up work that enables nonformal-formal collaboration and alignment, greater use of formal services, internally driven social change, and high levels of community ownership. The dominant approach of reliance on expert-driven Child Welfare Committees produces low levels of community ownership. Using an approach developed and tested in rural Sierra Leone, community-driven action, including collaboration and linkages with the formal system, promoted the use of formal services and achieved increased ownership, effectiveness, and sustainability of the system. The field needs less reliance on expert-driven approaches and much wider use of slower, community-driven, bottom-up approaches to child protection. Copyright © 2015 The Author. Published by Elsevier Ltd.. All rights reserved.

How does achievement motivation influence mental effort mobilization? Physiological evidence of deteriorative effects of negative affects on the level of engagement.

PubMed

Capa, Rémi L; Audiffren, Michel

2009-12-01

We tested whether the effect of achievement motivation on effort is modulated by two possible factors of the motivational intensity theory (Wright and Kirby, 2001): perceived difficulty and maximally justified effort. Approach-driven (N=16) and avoidance-driven (N=16) participants were first instructed to perform a reaction time task to the best of their abilities. Next, the participants were instructed to consistently beat their performance standard established in the first condition. Approach-driven participants showed a stronger decrease of midfrequency band of heart rate variability, which was used as an index of mental effort, than avoidance-driven participants in the second instruction condition. Moreover, avoidance-driven participants showed a higher corrugator supercilii reactivity, which was used as an index of negative affects, than approach-driven participants in the second instruction condition. No difference of perceived difficulty between groups was observed. Results suggested that avoidance-driven participants developed negative affects in the second instruction condition decreasing the maximally justified effort and their level of engagement.

Real-Time Global Nonlinear Aerodynamic Modeling for Learn-To-Fly

NASA Technical Reports Server (NTRS)

Morelli, Eugene A.

2016-01-01

Flight testing and modeling techniques were developed to accurately identify global nonlinear aerodynamic models for aircraft in real time. The techniques were developed and demonstrated during flight testing of a remotely-piloted subscale propeller-driven fixed-wing aircraft using flight test maneuvers designed to simulate a Learn-To-Fly scenario. Prediction testing was used to evaluate the quality of the global models identified in real time. The real-time global nonlinear aerodynamic modeling algorithm will be integrated and further tested with learning adaptive control and guidance for NASA Learn-To-Fly concept flight demonstrations.

Pre-Launch Tasks Proposed in our Contract of December 1991

NASA Technical Reports Server (NTRS)

1998-01-01

We propose, during the pre-EOS phase to: (1) develop, with other MODIS Team Members, a means of discriminating different major biome types with NDVI and other AVHRR-based data; (2) develop a simple ecosystem process model for each of these biomes, BIOME-BGC; (3) relate the seasonal trend of weekly composite NDVI to vegetation phenology and temperature limits to develop a satellite defined growing season for vegetation; and (4) define physiologically based energy to mass conversion factors for carbon and water for each biome. Our final core at-launch product will be simplified, completely satellite driven biome specific models for net primary production. We will build these biome specific satellite driven algorithms using a family of simple ecosystem process models as calibration models, collectively called BIOME-BGC, and establish coordination with an existing network of ecological study sites in order to test and validate these products. Field datasets will then be available for both BIOME-BGC development and testing, use for algorithm developments of other MODIS Team Members, and ultimately be our first test point for MODIS land vegetation products upon launch. We will use field sites from the National Science Foundation Long-Term Ecological Research network, and develop Glacier National Park as a major site for intensive validation.

Pre-Launch Tasks Proposed in our Contract of December 1991

NASA Technical Reports Server (NTRS)

Running, Steven W.; Nemani, Ramakrishna R.; Glassy, Joseph

1997-01-01

We propose, during the pre-EOS phase to: (1) develop, with other MODIS Team Members, a means of discriminating different major biome types with NDVI and other AVHRR-based data. (2) develop a simple ecosystem process model for each of these biomes, BIOME-BGC (3) relate the seasonal trend of weekly composite NDVI to vegetation phenology and temperature limits to develop a satellite defined growing season for vegetation; and (4) define physiologically based energy to mass conversion factors for carbon and water for each biome. Our final core at-launch product will be simplified, completely satellite driven biome specific models for net primary production. We will build these biome specific satellite driven algorithms using a family of simple ecosystem process models as calibration models, collectively called BIOME-BGC, and establish coordination with an existing network of ecological study sites in order to test and validate these products. Field datasets will then be available for both BIOME-BGC development and testing, use for algorithm developments of other MODIS Team Members, and ultimately be our first test point for MODIS land vegetation products upon launch. We will use field sites from the National Science Foundation Long-Term Ecological Research network, and develop Glacier National Park as a major site for intensive validation.

Test Driven Development of a Parameterized Ice Sheet Component

NASA Astrophysics Data System (ADS)

Clune, T.

2011-12-01

Test driven development (TDD) is a software development methodology that offers many advantages over traditional approaches including reduced development and maintenance costs, improved reliability, and superior design quality. Although TDD is widely accepted in many software communities, the suitability to scientific software is largely undemonstrated and warrants a degree of skepticism. Indeed, numerical algorithms pose several challenges to unit testing in general, and TDD in particular. Among these challenges are the need to have simple, non-redundant closed-form expressions to compare against the results obtained from the implementation as well as realistic error estimates. The necessity for serial and parallel performance raises additional concerns for many scientific applicaitons. In previous work I demonstrated that TDD performed well for the development of a relatively simple numerical model that simulates the growth of snowflakes, but the results were anecdotal and of limited relevance to far more complex software components typical of climate models. This investigation has now been extended by successfully applying TDD to the implementation of a substantial portion of a new parameterized ice sheet component within a full climate model. After a brief introduction to TDD, I will present techniques that address some of the obstacles encountered with numerical algorithms. I will conclude with some quantitative and qualitative comparisons against climate components developed in a more traditional manner.

Nanoparticles in medicine: Current challenges facing inorganic nanoparticle toxicity assessments and standardizations.

PubMed

Hofmann-Amtenbrink, Margarethe; Grainger, David W; Hofmann, Heinrich

2015-10-01

Although nanoparticles research is ongoing since more than 30years, the development of methods and standard protocols required for their safety and efficacy testing for human use is still in development. The review covers questions on toxicity, safety, risk and legal issues over the lifecycle of inorganic nanoparticles for medical applications. The following topics were covered: (i) In vitro tests may give only a very first indication of possible toxicity as in the actual methods interactions at systemic level are mainly neglected; (ii) the science-driven and the regulation-driven approaches do not really fit for decisive strategies whether or not a nanoparticle should be further developed and may receive a kind of "safety label". (iii) Cost and time of development are the limiting factors for the drug pipeline. Knowing which property of a nanoparticle makes it toxic it may be feasible to re-engineer the particle for higher safety (safety by design). Testing the safety and efficacy of nanoparticles for human use is still in need of standardization. In this concise review, the author described and discussed the current unresolved issues over the application of inorganic nanoparticles for medical applications. Copyright © 2015 Elsevier Inc. All rights reserved.

A hydraulically driven colonoscope.

PubMed

Coleman, Stuart A; Tapia-Siles, Silvia C; Pakleppa, Markus; Vorstius, Jan B; Keatch, Robert P; Tang, Benjie; Cuschieri, Alfred

2016-10-01

Conventional colonoscopy requires a high degree of operator skill and is often painful for the patient. We present a preliminary feasibility study of an alternative approach where a self-propelled colonoscope is hydraulically driven through the colon. A hydraulic colonoscope which could be controlled manually or automatically was developed and assessed in a test bed modelled on the anatomy of the human colon. A conventional colonoscope was used by an experienced colonoscopist in the same test bed for comparison. Pressures and forces on the colon were measured during the test. The hydraulic colonoscope was able to successfully advance through the test bed in a comparable time to the conventional colonoscope. The hydraulic colonoscope reduces measured loads on artificial mesenteries, but increases intraluminal pressure compared to the colonoscope. Both manual and automatically controlled modes were able to successfully advance the hydraulic colonoscope through the colon. However, the automatic controller mode required lower pressures than manual control, but took longer to reach the caecum. The hydraulic colonoscope appears to be a viable device for further development as forces and pressures observed during use are comparable to those used in current clinical practice.

Unconscious memory bias in depression: perceptual and conceptual processes.

PubMed

Watkins, P C; Martin, C K; Stern, L D

2000-05-01

Mood-congruent memory (MCM) bias in depression was investigated using 4 different implicit memory tests. Two of the implicit tests were perceptually driven, and 2 were conceptually driven. Depressed participants and nondepressed controls were assigned to 1 of 4 implicit memory tests after studying positive and negative adjectives. Results showed no MCM bias in the perceptually driven tests. MCM was demonstrated in 1 of the conceptually driven tests, but only for adjectives that were conceptually encoded. Results support the theory that mood-congruent processes in depression are limited to conceptual processing. However, activation of conceptual processes may not be sufficient for demonstrating mood congruency.

A predictive estimation method for carbon dioxide transport by data-driven modeling with a physically-based data model

NASA Astrophysics Data System (ADS)

Jeong, Jina; Park, Eungyu; Han, Weon Shik; Kim, Kue-Young; Jun, Seong-Chun; Choung, Sungwook; Yun, Seong-Taek; Oh, Junho; Kim, Hyun-Jun

2017-11-01

In this study, a data-driven method for predicting CO2 leaks and associated concentrations from geological CO2 sequestration is developed. Several candidate models are compared based on their reproducibility and predictive capability for CO2 concentration measurements from the Environment Impact Evaluation Test (EIT) site in Korea. Based on the data mining results, a one-dimensional solution of the advective-dispersive equation for steady flow (i.e., Ogata-Banks solution) is found to be most representative for the test data, and this model is adopted as the data model for the developed method. In the validation step, the method is applied to estimate future CO2 concentrations with the reference estimation by the Ogata-Banks solution, where a part of earlier data is used as the training dataset. From the analysis, it is found that the ensemble mean of multiple estimations based on the developed method shows high prediction accuracy relative to the reference estimation. In addition, the majority of the data to be predicted are included in the proposed quantile interval, which suggests adequate representation of the uncertainty by the developed method. Therefore, the incorporation of a reasonable physically-based data model enhances the prediction capability of the data-driven model. The proposed method is not confined to estimations of CO2 concentration and may be applied to various real-time monitoring data from subsurface sites to develop automated control, management or decision-making systems.

Maternal depressive symptoms, dysfunctional cognitions, and infant night waking: the role of maternal nighttime behavior.

PubMed

Teti, Douglas M; Crosby, Brian

2012-01-01

Mechanisms were examined to clarify relations between maternal depressive symptoms, dysfunctional cognitions, and infant night waking among 45 infants (1-24 months) and their mothers. A mother-driven mediational model was tested in which maternal depressive symptoms and dysfunctional cognitions about infant sleep predicted infant night waking via their impact on mothers' bedtime and nighttime behavior with infants (from video). Two infant-driven mediational models were also examined, in which infant night waking predicted maternal depressive symptoms, or dysfunctional cognitions, via their impact on nighttime maternal behavior. Stronger support for the mother-driven model was obtained, which was further supported by qualitative observations from video-recordings. This study provides important insights about maternal depression's effects on nighttime parenting, and how such parenting affects infant sleep. © 2012 The Authors. Child Development © 2012 Society for Research in Child Development, Inc.

Solar Energy Evolution and Diffusion Studies | Solar Research | NREL

Science.gov Websites

industry-wide studies that use data-driven and evidence-based methods to identify characteristics developed models of U.S. household PV adoption. The project also conducted two market pilots to test methods

Data Driven Professional Development Design for Out-of-School Time Educators Using Planetary Science and Engineering Educational Materials

NASA Astrophysics Data System (ADS)

Clark, J.; Bloom, N.

2017-12-01

Data driven design practices should be the basis for any effective educational product, particularly those used to support STEM learning and literacy. Planetary Learning that Advances the Nexus of Engineering, Technology, and Science (PLANETS) is a five-year NASA-funded (NNX16AC53A) interdisciplinary and cross-institutional partnership to develop and disseminate STEM out-of-school time (OST) curricular and professional development units that integrate planetary science, technology, and engineering. The Center for Science Teaching and Learning at Northern Arizona University, the U.S. Geological Survey Astrogeology Science Center, and the Museum of Science Boston are partners in developing, piloting, and researching the impact of three out of school time units. Two units are for middle grades youth and one is for upper elementary aged youth. The presentation will highlight the data driven development process of the educational products used to provide support for educators teaching these curriculum units. This includes how data from the project needs assessment, curriculum pilot testing, and professional support product field tests are used in the design of products for out of school time educators. Based on data analysis, the project is developing and testing four tiers of professional support for OST educators. Tier 1 meets the immediate needs of OST educators to teach curriculum and include how-to videos and other direct support materials. Tier 2 provides additional content and pedagogical knowledge and includes short content videos designed to specifically address the content of the curriculum. Tier 3 elaborates on best practices in education and gives guidance on methods, for example, to develop cultural relevancy for underrepresented students. Tier 4 helps make connections to other NASA or educational products that support STEM learning in out of school settings. Examples of the tiers of support will be provided.

"Spreading the Wealth": How Principals Use Performance Data to Populate Classrooms

ERIC Educational Resources Information Center

Osborne-Lampkin, La'Tara; Cohen-Vogel, Lora

2014-01-01

There is evidence that school leaders are using test score data for decisions about everything from the curriculum to what is served for lunch. Research suggests that staffing too is data-driven, with principals using test score data to hire, assign, and develop their teachers. Semi-structured interviews with principals and other school actors in…

Flexural Behavior of GFRP Tubes Filled with Magnetically Driven Concrete

PubMed Central

Xie, Fang; Chen, Ju; Dong, Xinlong; Feng, Bing

2018-01-01

Experimental investigation of GFRP (glass fiber reinforced polymer) tubes that were filled with magnetically driven concrete was carried out to study the flexural behavior of specimens under bending. Specimens having different cross section and lengths were tested. The test specimens were fabricated by filling magnetically driven concrete into the GFRP tubes and the concrete was vibrated using magnetic force. Specimens vibrated using vibrating tube were also tested for comparison. In addition, specimens having steel reinforcing bars and GFRP bars were both tested to study the effect of reinforcing bars on the magnetically driven concrete. The load-displacement curves, load-strain curves, failure mode, and ultimate strengths of test specimens were obtained. Design methods for the flexural stiffness of test specimens were also discussed in this study. PMID:29316732

Flexural Behavior of GFRP Tubes Filled with Magnetically Driven Concrete.

PubMed

Xie, Fang; Chen, Ju; Dong, Xinlong; Feng, Bing

2018-01-08

Experimental investigation of GFRP (glass fiber reinforced polymer) tubes that were filled with magnetically driven concrete was carried out to study the flexural behavior of specimens under bending. Specimens having different cross section and lengths were tested. The test specimens were fabricated by filling magnetically driven concrete into the GFRP tubes and the concrete was vibrated using magnetic force. Specimens vibrated using vibrating tube were also tested for comparison. In addition, specimens having steel reinforcing bars and GFRP bars were both tested to study the effect of reinforcing bars on the magnetically driven concrete. The load-displacement curves, load-strain curves, failure mode, and ultimate strengths of test specimens were obtained. Design methods for the flexural stiffness of test specimens were also discussed in this study.

Development of an Interactive Social Media Tool for Parents with Concerns about Vaccines

ERIC Educational Resources Information Center

Shoup, Jo Ann; Wagner, Nicole M.; Kraus, Courtney R.; Narwaney, Komal J.; Goddard, Kristin S.; Glanz, Jason M.

2015-01-01

Objective: Describe a process for designing, building, and evaluating a theory-driven social media intervention tool to help reduce parental concerns about vaccination. Method: We developed an interactive web-based tool using quantitative and qualitative methods (e.g., survey, focus groups, individual interviews, and usability testing). Results:…

Heavy Lift Helicopter - Prototype Technical Summary

DTIC Science & Technology

1980-04-01

in an inte- grated design. The following paragraphs discuss the swash - plate actuator servo loops and provide details...instrumentation in the prototype aircraft. Development testing of the flight control module in conjunc- tion with the transmission-driven pump and the reservoir was...PFCS employed cockpit controllers and force-feel actuation developed in the ATC

Evaluating Performance Measurement Systems in Nonprofit Agencies: The Program Accountability Quality Scale (PAQS).

ERIC Educational Resources Information Center

Poole, Dennis L.; Nelson, Joan; Carnahan, Sharon; Chepenik, Nancy G.; Tubiak, Christine

2000-01-01

Developed and field tested the Performance Accountability Quality Scale (PAQS) on 191 program performance measurement systems developed by nonprofit agencies in central Florida. Preliminary findings indicate that the PAQS provides a structure for obtaining expert opinions based on a theory-driven model about the quality of proposed measurement…

A Conformance Test Suite for Arden Syntax Compilers and Interpreters.

PubMed

Wolf, Klaus-Hendrik; Klimek, Mike

2016-01-01

The Arden Syntax for Medical Logic Modules is a standardized and well-established programming language to represent medical knowledge. To test the compliance level of existing compilers and interpreters no public test suite exists. This paper presents the research to transform the specification into a set of unit tests, represented in JUnit. It further reports on the utilization of the test suite testing four different Arden Syntax processors. The presented and compared results reveal the status conformance of the tested processors. How test driven development of Arden Syntax processors can help increasing the compliance with the standard is described with two examples. In the end some considerations how an open source test suite can improve the development and distribution of the Arden Syntax are presented.

pFUnit 3.0 Tutorial Advanced

NASA Technical Reports Server (NTRS)

Clune, Tom

2014-01-01

This tutorial will introduce Fortran developers to unit-testing and test-driven development (TDD) using pFUnit. As with other unit-testing frameworks, pFUnit, simplifies the process of writing, collecting, and executing tests while providing clear diagnostic messages for failing tests. pFUnit specifically targets the development of scientific-technical software written in Fortran and includes customized features such as: assertions for multi-dimensional arrays, distributed (MPI) and thread-based (OpenMP) parallellism, and flexible parameterized tests.These sessions will include numerous examples and hands-on exercises that gradually build in complexity. Attendees are expected to have working knowledge of F90, but familiarity with object-oriented syntax in F2003 and MPI will be of benefit for the more advanced examples. By the end of the tutorial the audience should feel comfortable in applying pFUnit within their own development environment.

ESTIMATING CONTAMINANT DOSE FOR INTERMITTENT DERMAL CONTACT: MODEL DEVELOPMENT, TESTING, AND APPLICATION

EPA Science Inventory

Assessments of aggregate exposure to pesticides and other surface contamination in residential environments are often driven by assumptions about dermal contacts. Accurately predicting cumulative doses from realistic skin contact scenarios requires characterization of exposure sc...

Fronting Integrated Scientific Web Applications: Design Features and Benefits for Regulatory Environments

EPA Science Inventory

Integrated decision support systems for regulatory applications benefit from standardindustry practices such as code reuse, test-driven development, and modularization. Theseapproaches make meeting the federal government’s goals of transparency, efficiency, and quality assurance ...

Automation, Miniature Robotics and Sensors for Nondestructive Testing and Evaluation, Volume 4

NASA Technical Reports Server (NTRS)

Bar-Cohen, Y.; Baumgartner, E.; Backes, P.; Sherrit, S.; Bao, X.; Leary, S.; Kennedy, B.; Mavroidis, C.; Pfeiffer, C.; Culbert, C.;

Rethinking developmental toxicity testing: Evolution or revolution?

PubMed

Scialli, Anthony R; Daston, George; Chen, Connie; Coder, Prägati S; Euling, Susan Y; Foreman, Jennifer; Hoberman, Alan M; Hui, Julia; Knudsen, Thomas; Makris, Susan L; Morford, LaRonda; Piersma, Aldert H; Stanislaus, Dinesh; Thompson, Kary E

2018-06-01

Current developmental toxicity testing adheres largely to protocols suggested in 1966 involving the administration of test compound to pregnant laboratory animals. After more than 50 years of embryo-fetal development testing, are we ready to consider a different approach to human developmental toxicity testing? A workshop was held under the auspices of the Developmental and Reproductive Toxicology Technical Committee of the ILSI Health and Environmental Sciences Institute to consider how we might design developmental toxicity testing if we started over with 21st century knowledge and techniques (revolution). We first consider what changes to the current protocols might be recommended to make them more predictive for human risk (evolution). The evolutionary approach includes modifications of existing protocols and can include humanized models, disease models, more accurate assessment and testing of metabolites, and informed approaches to dose selection. The revolution could start with hypothesis-driven testing where we take what we know about a compound or close analog and answer specific questions using targeted experimental techniques rather than a one-protocol-fits-all approach. Central to the idea of hypothesis-driven testing is the concept that testing can be done at the level of mode of action. It might be feasible to identify a small number of key events at a molecular or cellular level that predict an adverse outcome and for which testing could be performed in vitro or in silico or, rarely, using limited in vivo models. Techniques for evaluating these key events exist today or are in development. Opportunities exist for refining and then replacing current developmental toxicity testing protocols using techniques that have already been developed or are within reach. © 2018 The Authors. Birth Defects Research Published by Wiley Periodicals, Inc.

The Cascading Impacts of Technology Selection: Incorporating Ruby on Rails into ECHO

NASA Astrophysics Data System (ADS)

Pilone, D.; Cechini, M.

2010-12-01

NASA’s Earth Observing System (EOS) ClearingHOuse (ECHO) is a SOA based Earth Science Data search and order system implemented in Java with one significant exception: the web client used by 98% of our users is written in Perl. After several decades of maintenance the Perl based application had reached the end of its serviceable life and ECHO was tasked with implementing a replacement. Despite a broad investment in Java, the ECHO team conducted a survey of modern development technologies including Flex, Python/Django, JSF2/Spring and Ruby on Rails. The team ultimately chose Ruby on Rails (RoR) with Cucumber for testing due to its perceived applicability to web application development and corresponding development efficiency gains. Both positive and negative impacts on the entire ECHO team, including our stakeholders, were immediate and sometimes subtle. The technology selection caused shifts in our architecture and design, development and deployment procedures, requirement definition approach, testing approach, and, somewhat surprisingly, our project team structure and software process. This presentation discusses our experiences, including technical, process, and psychological, using RoR on a production system. During this session we will discuss: - Real impacts of introducing a dynamic language to a Java team - Real and perceived efficiency advantages - Impediments to adoption and effectiveness - Impacts of transition from Test Driven Development to Behavior Driven Development - Leveraging Cucumber to provide fully executable requirement documents - Impacts on team structure and roles

A predictive estimation method for carbon dioxide transport by data-driven modeling with a physically-based data model.

PubMed

Jeong, Jina; Park, Eungyu; Han, Weon Shik; Kim, Kue-Young; Jun, Seong-Chun; Choung, Sungwook; Yun, Seong-Taek; Oh, Junho; Kim, Hyun-Jun

2017-11-01

In this study, a data-driven method for predicting CO 2 leaks and associated concentrations from geological CO 2 sequestration is developed. Several candidate models are compared based on their reproducibility and predictive capability for CO 2 concentration measurements from the Environment Impact Evaluation Test (EIT) site in Korea. Based on the data mining results, a one-dimensional solution of the advective-dispersive equation for steady flow (i.e., Ogata-Banks solution) is found to be most representative for the test data, and this model is adopted as the data model for the developed method. In the validation step, the method is applied to estimate future CO 2 concentrations with the reference estimation by the Ogata-Banks solution, where a part of earlier data is used as the training dataset. From the analysis, it is found that the ensemble mean of multiple estimations based on the developed method shows high prediction accuracy relative to the reference estimation. In addition, the majority of the data to be predicted are included in the proposed quantile interval, which suggests adequate representation of the uncertainty by the developed method. Therefore, the incorporation of a reasonable physically-based data model enhances the prediction capability of the data-driven model. The proposed method is not confined to estimations of CO 2 concentration and may be applied to various real-time monitoring data from subsurface sites to develop automated control, management or decision-making systems. Copyright © 2017 Elsevier B.V. All rights reserved.

An Integrated Analysis-Test Approach

NASA Technical Reports Server (NTRS)

Kaufman, Daniel

2003-01-01

This viewgraph presentation provides an overview of a project to develop a computer program which integrates data analysis and test procedures. The software application aims to propose a new perspective to traditional mechanical analysis and test procedures and to integrate pre-test and test analysis calculation methods. The program also should also be able to be used in portable devices and allows for the 'quasi-real time' analysis of data sent by electronic means. Test methods reviewed during this presentation include: shaker swept sine and random tests, shaker shock mode tests, shaker base driven model survey tests and acoustic tests.

Recent European Developments in Helicopters

NASA Technical Reports Server (NTRS)

1921-01-01

Descriptions are given of two captured helicopters, one driven by electric power, the other by a gasoline engine. An account is given of flight tests of the gasoline powered vehicle. After 15 successful flight tests, the gasoline powered vehicle crashed due to the insufficient thrust. Also discussed here are the applications of helicopters for military observations, for meteorological work, and for carrying radio antennas.

Estimating Setup of Driven Piles into Louisiana Clayey Soils

DOT National Transportation Integrated Search

2009-11-15

Two types of mathematical models for pile setup prediction, the Skov-Denver model and the newly developed rate-based model, have been established from all the dynamic and static testing data, including restrikes of the production piles, restrikes, st...

Estimating setup of driven piles into Louisiana clayey soils.

DOT National Transportation Integrated Search

2010-11-15

Two types of mathematical models for pile setup prediction, the Skov-Denver model and the newly developed rate-based model, have been established from all the dynamic and static testing data, including restrikes of the production piles, restrikes, st...

Increase of stagnation pressure and enthalpy in shock tunnels

NASA Technical Reports Server (NTRS)

Bogdanoff, David W.; Cambier, Jean-Luc

1992-01-01

High stagnation pressures and enthalpies are required for the testing of aerospace vehicles such as aerospace planes, aeroassist vehicles, and reentry vehicles. Among the most useful ground test facilities for performing such tests are shock tunnels. With a given driver gas condition, the enthalpy and pressure in the driven tube nozzle reservoir condition can be varied by changing the driven tube geometry and initial gas fill pressure. Reducing the driven tube diameter yields only very modest increases in reservoir pressure and enthalpy. Reducing the driven tube initial gas fill pressure can increase the reservoir enthalpy significantly, but at the cost of reduced reservoir pressure and useful test time. A new technique, the insertion of a converging section in the driven tube is found to produce substantial increases in both reservoir pressure and enthalpy. Using a one-dimensional inviscid full kinetics code, a number of different locations and shapes for the converging driven tube section were studied and the best cases found. For these best cases, for driven tube diameter reductions of factors of 2 and 3, the reservoir pressure can be increased by factors of 2.1 and 3.2, respectively and the enthalpy can be increased by factors of 1.5 and 2.1, respectively.

Development of a plasma driven permeation experiment for TPE

DOE PAGES

Buchenauer, Dean; Kolasinski, Robert; Shimada, Masa; ...

2014-04-18

Experiments on retention of hydrogen isotopes (including tritium) at temperatures less than 800 ?C have been carried out in the Tritium Plasma Experiment (TPE) at Idaho National Laboratory [1,2]. To provide a direct measurement of plasma driven permeation in plasma facing materials at temperatures reaching 1000 ?C, a new TPE membrane holder has been built to hold test specimens (=1 mm in thickness) at high temperature while measuring tritium permeating through the membrane from the plasma facing side. This measurement is accomplished by employing a carrier gas that transports the permeating tritium from the backside of the membrane to ionmore » chambers giving a direct measurement of the plasma driven tritium permeation rate. Isolation of the membrane cooling and sweep gases from TPE’s vacuum chamber has been demonstrated by sealing tests performed up to 1000 ?C of a membrane holder design that provides easy change out of membrane specimens between tests. Simulations of the helium carrier gas which transports tritium to the ion chamber indicate a very small pressure drop (~700 Pa) with good flow uniformity (at 1000 sccm). Thermal transport simulations indicate that temperatures up to 1000 ?C are expected at the highest TPE fluxes.« less

Design, Development, and Testing of a Compound Wing V/TOL small UAS

NASA Technical Reports Server (NTRS)

Logan, Michael J.; Vranas, Thomas L.

2015-01-01

This paper discusses the development and testing of an innovative small UAS (Unmanned Aircraft System). The design of the vehicle was driven by the need to both have long endurance yet still have the convenience of V/TOL (Vertical Take-Off and Landing) operation. The paper discusses some of the design considerations and configurations evaluated in searching for a configuration that met the demanding mission requirements. The paper also discusses some aspects of the compound wing and experimental testing conducted to discern the optimum parameters for the wing's design. The paper discusses the results of the preliminary flight testing and outlines further research to be conducted.

Development of dry coal feeders

NASA Technical Reports Server (NTRS)

Bonin, J. H.; Cantey, D. E.; Daniel, A. D., Jr.; Meyer, J. W.

1977-01-01

Design and fabrication of equipment of feed coal into pressurized environments were investigated. Concepts were selected based on feeder system performance and economic projections. These systems include: two approaches using rotating components, a gas or steam driven ejector, and a modified standpipe feeder concept. Results of development testing of critical components, design procedures, and performance prediction techniques are reviewed.

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

The Vehicle and Systems Simulation and Testing research and development (R&D) subprogram within the DOE Vehicle Technologies Office (VTO) provides support and guidance for many cutting-edge automotive technologies under development. Research focuses on addressing critical barriers to advancing light-, medium-, and heavy-duty vehicle systems to help maximize the number of electric miles driven and increase the energy efficiency of transportation vehicles.

Solder Joint Health Monitoring Testbed

NASA Technical Reports Server (NTRS)

Delaney, Michael M.; Flynn, James; Browder, Mark

2009-01-01

A method of monitoring the health of selected solder joints, called SJ-BIST, has been developed by Ridgetop Group Inc. under a Small Business Innovative Research (SBIR) contract. The primary goal of this research program is to test and validate this method in a flight environment using realistically seeded faults in selected solder joints. An additional objective is to gather environmental data for future development of physics-based and data-driven prognostics algorithms. A test board is being designed using a Xilinx FPGA. These boards will be tested both in flight and on the ground using a shaker table and an altitude chamber.

Design and development of a high-speed bearing test rig

NASA Technical Reports Server (NTRS)

Cockburn, J. A.

1995-01-01

The development of a high-speed test rig, to be used for compiling an experimental data base of bearing signatures for bearings with known faults, is described. This bearing test rig can be adapted to test oil-film bearings as well as rolling element bearings. This is achieved by mounting the test bearing in one of two special test housings, either of which can be mounted onto a common test shaft which can be driven up to 30,000 rpm. The test bearing housing for rolling element bearings can accommodate proximity displacement transducers, accelerometers, thermocouples, and acoustic emission sensors. The test bearing housing for the fluid-film bearings can accommodate the same instrumentation as well as Bourdon tube-type transducers for measuring oil film pressures around the bearing circumference.

Hybrid statistical testing for nuclear material accounting data and/or process monitoring data in nuclear safeguards

DOE PAGES

Burr, Tom; Hamada, Michael S.; Ticknor, Larry; ...

2015-01-01

The aim of nuclear safeguards is to ensure that special nuclear material is used for peaceful purposes. Historically, nuclear material accounting (NMA) has provided the quantitative basis for monitoring for nuclear material loss or diversion, and process monitoring (PM) data is collected by the operator to monitor the process. PM data typically support NMA in various ways, often by providing a basis to estimate some of the in-process nuclear material inventory. We develop options for combining PM residuals and NMA residuals (residual = measurement - prediction), using a hybrid of period-driven and data-driven hypothesis testing. The modified statistical tests canmore » be used on time series of NMA residuals (the NMA residual is the familiar material balance), or on a combination of PM and NMA residuals. The PM residuals can be generated on a fixed time schedule or as events occur.« less

Radio-Frequency Driven Dielectric Heaters for Non-Nuclear Testing in Nuclear Core Development

NASA Technical Reports Server (NTRS)

Sims, William Herbert, III (Inventor); Godfroy, Thomas J. (Inventor); Bitteker, Leo (Inventor)

2006-01-01

Apparatus and methods are provided through which a radiofrequency dielectric heater has a cylindrical form factor, a variable thermal energy deposition through variations in geometry and composition of a dielectric, and/or has a thermally isolated power input.

Particle transport patterns of short-distance soil erosion by wind-driven rain, rain and wind

NASA Astrophysics Data System (ADS)

Marzen, Miriam; Iserloh, Thomas; de Lima, João L. M. P.; Ries, Johannes B.

2015-04-01

Short distance erosion of soil surface material is one of the big question marks in soil erosion studies. The exact measurement of short-distance transported soil particles, prior to the occurrence of overland flow, is a challenge to soil erosion science due to the particular requirements of the experimental setup and test procedure. To approach a quantification of amount and distance of each type of transport, we applied an especially developed multiple-gutter system installed inside the Trier Portable Wind and Rainfall Simulator (PWRS). We measured the amount and travel distance of soil particles detached and transported by raindrops (splash), wind-driven rain (splash-saltation and splash-drift) and wind (saltation). The test setup included three different erosion agents (rain/ wind-driven rain/ wind), two substrates (sandy/ loamy), three surface structures (grain roughness/ rills lengthwise/ rills transversal) and three slope angles (0°/+7°/-7°). The results present detailed transport patterns of the three erosion agents under the varying soil and surface conditions up to a distance of 1.6 m. Under the applied rain intensity and wind velocity, wind-driven rain splash generates the highest erosion. The erodibility and travel distance of the two substrates depend on the erosion agent. The total erosion is slightly higher for the slope angle -7° (downslope), but for wind-driven rain splash, the inclination is not a relevant factor. The effect of surface structures (rills) changes with traveling distance. The wind driven rain splash generates a much higher amount of erosion and a further travel distance of the particles due to the combined action of wind and rain. The wind-driven rain factor appears to be much more significant than the other factors. The study highlights the effects of different erosion agents and surface parameters on short-distance particle transport and the powerful impact of wind-driven rain on soil erosion.

Environmental testing of flat plate solar cell modules

NASA Technical Reports Server (NTRS)

Griffith, J.; Dumas, L.; Hoffman, A.

1978-01-01

Commercially available flat-plate solar cell modules have been subjected to a variety of environmental tests designed to simulate service conditions. Among the tests are those simulating heat and rain, wind-driven rains, humidity and freezing, humidity and heat, humidity with a voltage bias, salt fog, hail impact, and fungus infestation. Tests for optical surface soiling and the combined effects of temperature, humidity and UV irradiation are under development. A correlation has been demonstrated between degradation caused by the qualification tests and such observed field effects as power loss.

A Data System for a Rapid Evaluation Class of Subscale Aerial Vehicle

NASA Technical Reports Server (NTRS)

Hogge, Edward F.; Quach, Cuong C.; Vazquez, Sixto L.; Hill, Boyd L.

2011-01-01

A low cost, rapid evaluation, test aircraft is used to develop and test airframe damage diagnosis algorithms at Langley Research Center as part of NASA's Aviation Safety Program. The remotely operated subscale aircraft is instrumented with sensors to monitor structural response during flight. Data is collected for good and compromised airframe configurations to develop data driven models for diagnosing airframe state. This paper describes the data acquisition system (DAS) of the rapid evaluation test aircraft. A PC/104 form factor DAS was developed to allow use of Matlab, Simulink simulation code in Langley's existing subscale aircraft flight test infrastructure. The small scale of the test aircraft permitted laboratory testing of the actual flight article under controlled conditions. The low cost and modularity of the DAS permitted adaptation to various flight experiment requirements.

Combustion Studies of Acoustically Suspended Liquid Droplets.

DTIC Science & Technology

1988-03-01

34, 2 1 02 J Acoustic Levitation .’ ABSTRACT (Continue on reverse if necessary and identify by block number) piezoelectrically driven ultrasonic resonator...was developed and tested in this study. The device was used to levitate liquid fuel droplets for evaporation measurements and ignition :tudies. The... levitation technique may hold some promise for onducting non-combustion related droplet measurements, for example evaporation tests, but wIthout further

Temporal Code-Driven Stimulation: Definition and Application to Electric Fish Signaling

PubMed Central

Lareo, Angel; Forlim, Caroline G.; Pinto, Reynaldo D.; Varona, Pablo; Rodriguez, Francisco de Borja

2016-01-01

Closed-loop activity-dependent stimulation is a powerful methodology to assess information processing in biological systems. In this context, the development of novel protocols, their implementation in bioinformatics toolboxes and their application to different description levels open up a wide range of possibilities in the study of biological systems. We developed a methodology for studying biological signals representing them as temporal sequences of binary events. A specific sequence of these events (code) is chosen to deliver a predefined stimulation in a closed-loop manner. The response to this code-driven stimulation can be used to characterize the system. This methodology was implemented in a real time toolbox and tested in the context of electric fish signaling. We show that while there are codes that evoke a response that cannot be distinguished from a control recording without stimulation, other codes evoke a characteristic distinct response. We also compare the code-driven response to open-loop stimulation. The discussed experiments validate the proposed methodology and the software toolbox. PMID:27766078

Temporal Code-Driven Stimulation: Definition and Application to Electric Fish Signaling.

PubMed

Lareo, Angel; Forlim, Caroline G; Pinto, Reynaldo D; Varona, Pablo; Rodriguez, Francisco de Borja

2016-01-01

Closed-loop activity-dependent stimulation is a powerful methodology to assess information processing in biological systems. In this context, the development of novel protocols, their implementation in bioinformatics toolboxes and their application to different description levels open up a wide range of possibilities in the study of biological systems. We developed a methodology for studying biological signals representing them as temporal sequences of binary events. A specific sequence of these events (code) is chosen to deliver a predefined stimulation in a closed-loop manner. The response to this code-driven stimulation can be used to characterize the system. This methodology was implemented in a real time toolbox and tested in the context of electric fish signaling. We show that while there are codes that evoke a response that cannot be distinguished from a control recording without stimulation, other codes evoke a characteristic distinct response. We also compare the code-driven response to open-loop stimulation. The discussed experiments validate the proposed methodology and the software toolbox.

Network operating system focus technology

NASA Technical Reports Server (NTRS)

1985-01-01

An activity structured to provide specific design requirements and specifications for the Space Station Data Management System (DMS) Network Operating System (NOS) is outlined. Examples are given of the types of supporting studies and implementation tasks presently underway to realize a DMS test bed capability to develop hands-on understanding of NOS requirements as driven by actual subsystem test beds participating in the overall Johnson Space Center test bed program. Classical operating system elements and principal NOS functions are listed.

Simulations of material mixing in laser-driven reshock experiments

NASA Astrophysics Data System (ADS)

Haines, Brian M.; Grinstein, Fernando F.; Welser-Sherrill, Leslie; Fincke, James R.

2013-02-01

We perform simulations of a laser-driven reshock experiment [Welser-Sherrill et al., High Energy Density Phys. (unpublished)] in the strong-shock high energy-density regime to better understand material mixing driven by the Richtmyer-Meshkov instability. Validation of the simulations is based on direct comparison of simulation and radiographic data. Simulations are also compared with published direct numerical simulation and the theory of homogeneous isotropic turbulence. Despite the fact that the flow is neither homogeneous, isotropic nor fully turbulent, there are local regions in which the flow demonstrates characteristics of homogeneous isotropic turbulence. We identify and isolate these regions by the presence of high levels of turbulent kinetic energy (TKE) and vorticity. After reshock, our analysis shows characteristics consistent with those of incompressible isotropic turbulence. Self-similarity and effective Reynolds number assessments suggest that the results are reasonably converged at the finest resolution. Our results show that in shock-driven transitional flows, turbulent features such as self-similarity and isotropy only fully develop once de-correlation, characteristic vorticity distributions, and integrated TKE, have decayed significantly. Finally, we use three-dimensional simulation results to test the performance of two-dimensional Reynolds-averaged Navier-Stokes simulations. In this context, we also test a presumed probability density function turbulent mixing model extensively used in combustion applications.

Development and evaluation of yeast-based GFP and luciferase reporter assays for chemical-induced genotoxicity and oxidative damage.

PubMed

Suzuki, Hajime; Sakabe, Takahiro; Hirose, Yuu; Eki, Toshihiko

2017-01-01

We aimed to develop the bioassays for genotixicity and/or oxidative damage using the recombinant yeast. A genotoxicity assay was developed using recombinant Saccharomyces cerevisiae strain BY4741 with a green fluorescent protein (GFP) reporter plasmid, driven by the DNA damage-responsive RNR3 promoter. Enhanced fluorescence induction was observed in DNA repair-deficient strains treated with methyl methanesulfonate, but not with hydrogen peroxide. A GFP reporter yeast strain driven by the oxidative stress-responsive TRX2 promoter was newly developed to assess oxidative damage, but fluorescence was poorly induced by oxidants. In place of GFP, yeast strains with luciferase gene reporter plasmids (luc2 and luc2CP, encoding stable and unstable luciferase, respectively) were prepared. Transient induction of luciferase activity was clearly detected only in a TRX2 promoter-driven luc2CP reporter strain within 90 min of oxidant exposure. However, luciferase was strongly induced by hydroxyurea in the RNR3 promoter-driven luc2 and GFP reporter strains over 8 h after the exposure, suggesting that the RNR3 promoter is continuously upregulated by DNA damage, whereas the TRX2 promoter is transiently activated by oxidative agents. Luciferase activity levels were also increased in a TRX2-promoter-driven luc2CP reporter strain treated with tert-butyl hydroperoxide and menadione and weakly induced with diamide and diethyl maleate. Weakly enhanced luciferase activity induction was detected in the sod1Δ, sod2Δ, and rad27Δ strains treated with hydrogen peroxide compared with that in the wild-type strain. In conclusion, tests using GFP and stable luciferase reporters are useful for genotoxicity, and oxidative damage can be clearly detected by assay with an unstable luciferase reporter.

Influence of Test Section Geometry on the Blast Environment in an Explosively Driven Conical Shock Tube

DTIC Science & Technology

2018-03-30

ARL-TR-8335•MAR 2018 US Army Research Laboratory Influence of Test Section Geometry on theBlast Environment in an Explosively DrivenConical Shock...ARL-TR-8335•MAR 2018 US Army Research Laboratory Influence of Test Section Geometry on theBlast Environment in an Explosively DrivenConical Shock...Tube by Joel B Stewart Weapons and Materials Research Directorate, ARL Approved for public release; distribution is unlimited. REPORT DOCUMENTATION

Commercial opportunities in bioseparations and physiological testing aboard Space Station Freedom

NASA Technical Reports Server (NTRS)

Hymer, W. C.

1992-01-01

The Center for Cell Research (CCR) is a NASA Center for the Commercial Development of Space which has as its main goal encouraging industry-driven biomedical/biotechnology space projects. Space Station Freedom (SSF) will provide long duration, crew-tended microgravity environments which will enhance the opportunities for commercial biomedical/biotechnology projects in bioseparations and physiological testing. The CCR bioseparations program, known as USCEPS (for United States Commercial Electrophoresis Program in Space), is developing access for American industry to continuous-flow electrophoresis aboard SSF. In space, considerable scale-up of continuous free-flow electrophoresis is possible for cells, sub cellular particles, proteins, growth factors, and other biological products. The lack of sedemination and buoyancy-driven convection flow enhances purity of separations and the amount of material processed/time. Through the CCR's physiological testing program, commercial organizations will have access aboard SSF to physiological systems experiments (PSE's); the Penn State Biomodule; and telemicroscopy. Physiological systems experiments involve the use of live animals for pharmaceutical product testing and discovery research. The Penn State Biomodule is a computer-controlled mini lab useful for projects involving live cells or tissues and macro molecular assembly studies, including protein crystallization. Telemicroscopy will enable staff on Earth to manipulate and monitor microscopic specimens on SSF for product development and discovery research or for medical diagnosis of astronaut health problems. Space-based product processing, testing, development, and discovery research using USCEPS and CCR's physiological testing program offer new routes to improved health on Earth. Direct crew involvement-in biomedical/biotechnology projects aboard SSF will enable better experimental outcomes. The current data base shows that there is reason for considerable optimism regarding what the CCDS program and the biomedical/biotechnology industry can expect to gain from a permanent manned presence in space.

Testing the Accuracy of Data-driven MHD Simulations of Active Region Evolution and Eruption

NASA Astrophysics Data System (ADS)

Leake, J. E.; Linton, M.; Schuck, P. W.

2017-12-01

Models for the evolution of the solar coronal magnetic field are vital for understanding solar activity, yet the best measurements of the magnetic field lie at the photosphere, necessitating the recent development of coronal models which are "data-driven" at the photosphere. Using magnetohydrodynamic simulations of active region formation and our recently created validation framework we investigate the source of errors in data-driven models that use surface measurements of the magnetic field, and derived MHD quantities, to model the coronal magnetic field. The primary sources of errors in these studies are the temporal and spatial resolution of the surface measurements. We will discuss the implications of theses studies for accurately modeling the build up and release of coronal magnetic energy based on photospheric magnetic field observations.

Engaging Faculty in the Assessment and Improvement of Students' Critical Thinking Using the Critical Thinking Assessment Test

ERIC Educational Resources Information Center

Stein, Barry; Haynes, Ada

2011-01-01

Many assessment experts believe it is essential to develop faculty-driven assessment tools in order to engage faculty in meaningful assessment that can improve student learning. Tennessee Technological University (TTU) has been involved in an extended effort during the last ten years to develop, refine, and nationally disseminate an instrument to…

Early developments in solar cooling equipment

NASA Technical Reports Server (NTRS)

Price, J. M.

1978-01-01

A brief description of a development program to design, fabricate and field test a series of solar operated or driven cooling devices, undertaken by the Marshall Space Flight Center in the context of the Solar Heating and Cooling Demonstration Act of 1974, is presented. Attention is given to two basic design concepts: the Rankine cycle principle and the use of a dessicant for cooling.

Cognitive Effects of Mindfulness Training: Results of a Pilot Study Based on a Theory Driven Approach

PubMed Central

Wimmer, Lena; Bellingrath, Silja; von Stockhausen, Lisa

2016-01-01

The present paper reports a pilot study which tested cognitive effects of mindfulness practice in a theory-driven approach. Thirty-four fifth graders received either a mindfulness training which was based on the mindfulness-based stress reduction approach (experimental group), a concentration training (active control group), or no treatment (passive control group). Based on the operational definition of mindfulness by Bishop et al. (2004), effects on sustained attention, cognitive flexibility, cognitive inhibition, and data-driven as opposed to schema-based information processing were predicted. These abilities were assessed in a pre-post design by means of a vigilance test, a reversible figures test, the Wisconsin Card Sorting Test, a Stroop test, a visual search task, and a recognition task of prototypical faces. Results suggest that the mindfulness training specifically improved cognitive inhibition and data-driven information processing. PMID:27462287

Cognitive Effects of Mindfulness Training: Results of a Pilot Study Based on a Theory Driven Approach.

PubMed

Wimmer, Lena; Bellingrath, Silja; von Stockhausen, Lisa

2016-01-01

The present paper reports a pilot study which tested cognitive effects of mindfulness practice in a theory-driven approach. Thirty-four fifth graders received either a mindfulness training which was based on the mindfulness-based stress reduction approach (experimental group), a concentration training (active control group), or no treatment (passive control group). Based on the operational definition of mindfulness by Bishop et al. (2004), effects on sustained attention, cognitive flexibility, cognitive inhibition, and data-driven as opposed to schema-based information processing were predicted. These abilities were assessed in a pre-post design by means of a vigilance test, a reversible figures test, the Wisconsin Card Sorting Test, a Stroop test, a visual search task, and a recognition task of prototypical faces. Results suggest that the mindfulness training specifically improved cognitive inhibition and data-driven information processing.

Fabrication and test of digital output interface devices for gas turbine electronic controls

NASA Technical Reports Server (NTRS)

Newirth, D. M.; Koenig, E. W.

1978-01-01

A program was conducted to develop an innovative digital output interface device, a digital effector with optical feedback of the fuel metering valve position, for future electronic controls for gas turbine engines. A digital effector (on-off solenoids driven directly by on-off signals from a digital electronic controller) with optical position feedback was fabricated, coupled with the fuel metering valve, and tested under simulated engine operating conditions. The testing indicated that a digital effector with optical position feedback is a suitable candidate, with proper development for future digital electronic gas turbine controls. The testing also identified several problem areas which would have to be overcome in a final production configuration.

Grouper tshβ Promoter-Driven Transgenic Zebrafish Marks Proximal Kidney Tubule Development

PubMed Central

Wang, Yang; Sun, Zhi-Hui; Zhou, Li; Li, Zhi; Gui, Jian-Fang

2014-01-01

Kidney tubule plays a critical role in recovering or secreting solutes, but the detailed morphogenesis remains unclear. Our previous studies have found that grouper tshβ (gtshβ) is also expressed in kidney, however, the distribution significance is still unknown. To understand the gtshβ role and kidney tubule morphogenesis, here, we have generated a transgenic zebrafish line Tg(gtshβ:GFP) with green fluorescent protein driven by the gtshβ promoter. Similar to the endogenous tshβ in zebrafish or in grouper, the gtshβ promoter-driven GFP is expressed in pituitary and kidney, and the developing details of proximal kidney tubule are marked in the transgenic zebrafish line. The gfp initially transcribes at 16 hours post fertilization (hpf) above the dorsal mesentery, and partially co-localizes with pronephric tubular markers slc20a1a and cdh17. Significantly, the GFP specifically localizes in proximal pronephric segments during embryogenesis and resides at kidney duct epithelium in adult fish. To test whether the gtshβ promoter-driven GFP may serve as a readout signal of the tubular development, we have treated the embryos with retinoic acid signaing (RA) reagents, in which exogenous RA addition results in a distal extension of the proximal segments, while RA inhibition induces a weakness and shortness of the proximal segments. Therefore, this transgenic line provides a useful tool for genetic or chemical analysis of kidney tubule. PMID:24905828

NEW METHODS TO SCREEN FOR DEVELOPMENTAL NEUROTOXICITY.

EPA Science Inventory

The development of alternative methods for toxicity testing is driven by the need for scientifically valid data (i.e. predictive of a toxic effect) that can be obtained in a rapid and cost-efficient manner. These predictions will enable decisions to be made as to whether further ...

The contribution of the “SolCAP” project to potato breeding

USDA-ARS?s Scientific Manuscript database

Potato variety development in the US is driven by public sector scientists interacting with state and national grower organizations to test and commercialize new varieties. The processing market drives the breeding focus while disease and insect resistances may have regional importance. Based upon s...

Hydraulic Apparatus for Mechanical Testing of Nuts

NASA Technical Reports Server (NTRS)

Hinkel, Todd J.; Dean, Richard J.; Hacker, Scott C.; Harrington, Douglas W.; Salazar, Frank

2004-01-01

The figure depicts an apparatus for mechanical testing of nuts. In the original application for which the apparatus was developed, the nuts are of a frangible type designed for use with pyrotechnic devices in spacecraft applications in which there are requirements for rapid, one-time separations of structures that are bolted together. The apparatus can also be used to test nonfrangible nuts engaged without pyrotechnic devices. This apparatus was developed to replace prior testing systems that were extremely heavy and immobile and characterized by long setup times (of the order of an hour for each nut to be tested). This apparatus is mobile, and the setup for each test can now be completed in about five minutes. The apparatus can load a nut under test with a static axial force of as much as 6.8 x 10(exp 5) lb (3.0 MN) and a static moment of as much as 8.5 x 10(exp 4) lb in. (9.6 x 10(exp 3) N(raised dot)m) for a predetermined amount of time. In the case of a test of a frangible nut, the pyrotechnic devices can be exploded to break the nut while the load is applied, in which case the breakage of the nut relieves the load. The apparatus can be operated remotely for safety during an explosive test. The load-generating portion of the apparatus is driven by low-pressure compressed air; the remainder of the apparatus is driven by 110-Vac electricity. From its source, the compressed air is fed to the apparatus through a regulator and a manually operated valve. The regulated compressed air is fed to a pneumatically driven hydraulic pump, which pressurizes oil in a hydraulic cylinder, thereby causing a load to be applied via a hydraulic nut (not to be confused with the nut under test). During operation, the hydraulic pressure is correlated with the applied axial load, which is verified by use of a load cell. Prior to operation, one end of a test stud (which could be an ordinary threaded rod or bolt) is installed in the hydraulic nut. The other end of the test stud passes through a bearing plate; a load cell is slid onto that end, and then the nut to be tested is threaded onto that end and tightened until the nut and load cell press gently against the bearing plate.

Orientation of Steel Fibers in Magnetically Driven Concrete and Mortar.

PubMed

Xue, Wen; Chen, Ju; Xie, Fang; Feng, Bing

2018-01-22

The orientation of steel fibers in magnetically driven concrete and magnetically driven mortar was experimentally studied in this paper using a magnetic method. In the magnetically driven concrete, a steel slag was used to replace the coarse aggregate. In the magnetically driven mortar, steel slag and iron sand were used to replace the fine aggregate. A device was established to provide the magnetic force. The magnetic force was used to rotate the steel fibers. In addition, the magnetic force was also used to vibrate the concrete and mortar. The effect of magnetic force on the orientation of steel fibers was examined by comparing the direction of fibers before and after vibration. The effect of magnetically driven concrete and mortar on the orientation of steel fibers was also examined by comparing specimens to normal concrete and mortar. It is shown that the fibers could rotate about 90° in magnetically driven concrete. It is also shown that the number of fibers rotated in magnetically driven mortar was much more than in mortar vibrated using a shaking table. A splitting test was performed on concrete specimens to investigate the effect of fiber orientation. In addition, a flexural test was also performed on mortar test specimens. It is shown that the orientation of the steel fibers in magnetically driven concrete and mortar affects the strength of the concrete and mortar specimens.

Orientation of Steel Fibers in Magnetically Driven Concrete and Mortar

PubMed Central

Xue, Wen; Chen, Ju; Xie, Fang; Feng, Bing

2018-01-01

The orientation of steel fibers in magnetically driven concrete and magnetically driven mortar was experimentally studied in this paper using a magnetic method. In the magnetically driven concrete, a steel slag was used to replace the coarse aggregate. In the magnetically driven mortar, steel slag and iron sand were used to replace the fine aggregate. A device was established to provide the magnetic force. The magnetic force was used to rotate the steel fibers. In addition, the magnetic force was also used to vibrate the concrete and mortar. The effect of magnetic force on the orientation of steel fibers was examined by comparing the direction of fibers before and after vibration. The effect of magnetically driven concrete and mortar on the orientation of steel fibers was also examined by comparing specimens to normal concrete and mortar. It is shown that the fibers could rotate about 90° in magnetically driven concrete. It is also shown that the number of fibers rotated in magnetically driven mortar was much more than in mortar vibrated using a shaking table. A splitting test was performed on concrete specimens to investigate the effect of fiber orientation. In addition, a flexural test was also performed on mortar test specimens. It is shown that the orientation of the steel fibers in magnetically driven concrete and mortar affects the strength of the concrete and mortar specimens. PMID:29361798

Rapid Design and Testing of Novel Gas/liquid Contacting Devices for Post-Combustion CO 2 Capture via 3D Printing - Phase II Final Technical Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Panaccione, Charles; Staab, Greg; Meuleman, Erik

ION has developed a mathematically driven model for a contacting device incorporating mass transfer, heat transfer, and computational fluid dynamics. This model is based upon a parametric structure for purposes of future commercialization. The most promising design from modeling was 3D printed and tested in a bench scale CO 2 capture unit and compared to commercially available structured packing tested in the same unit.

Evaluation of axial pile bearing capacity based on pile driving analyzer (PDA) test using Neural Network

NASA Astrophysics Data System (ADS)

Maizir, H.; Suryanita, R.

2018-01-01

A few decades, many methods have been developed to predict and evaluate the bearing capacity of driven piles. The problem of the predicting and assessing the bearing capacity of the pile is very complicated and not yet established, different soil testing and evaluation produce a widely different solution. However, the most important thing is to determine methods used to predict and evaluate the bearing capacity of the pile to the required degree of accuracy and consistency value. Accurate prediction and evaluation of axial bearing capacity depend on some variables, such as the type of soil, diameter, and length of pile, etc. The aims of the study of Artificial Neural Networks (ANNs) are utilized to obtain more accurate and consistent axial bearing capacity of a driven pile. ANNs can be described as mapping an input to the target output data. The method using the ANN model developed to predict and evaluate the axial bearing capacity of the pile based on the pile driving analyzer (PDA) test data for more than 200 selected data. The results of the predictions obtained by the ANN model and the PDA test were then compared. This research as the neural network models give a right prediction and evaluation of the axial bearing capacity of piles using neural networks.

Design, manufacture, and test of coolant pump-motor assembly for Brayton power conversion system

NASA Technical Reports Server (NTRS)

Gabacz, L. E.

1973-01-01

The design, development, fabrication, and testing of seven coolant circulating pump-motor assemblies are discussed. The pump-motor assembly is driven by the nominal 44.4-volt, 400-Hz, 3-phase output of a nominal 56-volt dc input inverter. The pump-motor assembly will be used to circulate Dow Corning 200 liquid coolant for use in a Brayton cycle space power system. The pump-motor assembly develops a nominal head of 70 psi at 3.7 gpm with an over-all efficiency of 26 percent. The design description, drawings, photographs, reliability results, and developmental and acceptance test results are included.

Incremental cost-effectiveness of algorithm-driven genetic testing versus no testing for Maturity Onset Diabetes of the Young (MODY) in Singapore.

PubMed

Nguyen, Hai Van; Finkelstein, Eric Andrew; Mital, Shweta; Gardner, Daphne Su-Lyn

2017-11-01

Offering genetic testing for Maturity Onset Diabetes of the Young (MODY) to all young patients with type 2 diabetes has been shown to be not cost-effective. This study tests whether a novel algorithm-driven genetic testing strategy for MODY is incrementally cost-effective relative to the setting of no testing. A decision tree was constructed to estimate the costs and effectiveness of the algorithm-driven MODY testing strategy and a strategy of no genetic testing over a 30-year time horizon from a payer's perspective. The algorithm uses glutamic acid decarboxylase (GAD) antibody testing (negative antibodies), age of onset of diabetes (<45 years) and body mass index (<25 kg/m 2 if diagnosed >30 years) to stratify the population of patients with diabetes into three subgroups, and testing for MODY only among the subgroup most likely to have the mutation. Singapore-specific costs and prevalence of MODY obtained from local studies and utility values sourced from the literature are used to populate the model. The algorithm-driven MODY testing strategy has an incremental cost-effectiveness ratio of US$93 663 per quality-adjusted life year relative to the no testing strategy. If the price of genetic testing falls from US$1050 to US$530 (a 50% decrease), it will become cost-effective. Our proposed algorithm-driven testing strategy for MODY is not yet cost-effective based on established benchmarks. However, as genetic testing prices continue to fall, this strategy is likely to become cost-effective in the near future. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

14 CFR Appendix F to Part 36 - Flyover Noise Requirements for Propeller-Driven Small Airplane and Propeller-Driven, Commuter...

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Flyover Noise Requirements for Propeller-Driven Small Airplane and Propeller-Driven, Commuter Category Airplane Certification Tests Prior to.... F Appendix F to Part 36—Flyover Noise Requirements for Propeller-Driven Small Airplane and Propeller...

14 CFR Appendix F to Part 36 - Flyover Noise Requirements for Propeller-Driven Small Airplane and Propeller-Driven, Commuter...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Flyover Noise Requirements for Propeller-Driven Small Airplane and Propeller-Driven, Commuter Category Airplane Certification Tests Prior to.... F Appendix F to Part 36—Flyover Noise Requirements for Propeller-Driven Small Airplane and Propeller...

14 CFR Appendix F to Part 36 - Flyover Noise Requirements for Propeller-Driven Small Airplane and Propeller-Driven, Commuter...

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Flyover Noise Requirements for Propeller-Driven Small Airplane and Propeller-Driven, Commuter Category Airplane Certification Tests Prior to.... F Appendix F to Part 36—Flyover Noise Requirements for Propeller-Driven Small Airplane and Propeller...

14 CFR Appendix F to Part 36 - Flyover Noise Requirements for Propeller-Driven Small Airplane and Propeller-Driven, Commuter...

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Flyover Noise Requirements for Propeller-Driven Small Airplane and Propeller-Driven, Commuter Category Airplane Certification Tests Prior to.... F Appendix F to Part 36—Flyover Noise Requirements for Propeller-Driven Small Airplane and Propeller...

14 CFR Appendix F to Part 36 - Flyover Noise Requirements for Propeller-Driven Small Airplane and Propeller-Driven, Commuter...

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Flyover Noise Requirements for Propeller-Driven Small Airplane and Propeller-Driven, Commuter Category Airplane Certification Tests Prior to.... F Appendix F to Part 36—Flyover Noise Requirements for Propeller-Driven Small Airplane and Propeller...

Fuel savings with conventional hot water space heating systems by incorporating a natural gas powered heat pump. Preliminary project: Development of heat pump technology

NASA Astrophysics Data System (ADS)

Vanheyden, L.; Evertz, E.

1980-12-01

Compression type air/water heat pumps were developed for domestic heating systems rated at 20 to 150 kW. The heat pump is driven either by a reciprocating piston or rotary piston engine modified to operate on natural gas. Particular features of natural gas engines as prime movers, such as waste heat recovery and variable speed, are stressed. Two systems suitable for heat pump operation were selected from among five different mass produced car engines and were modified to incorporate reciprocating piston compressor pairs. The refrigerants used are R 12 and R 22. Test rig data transferred to field conditions show that the fuel consumption of conventional boilers can be reduced by 50% and more by the installation of engine driven heat pumps. Pilot heat pumps based on a 1,600 cc reciprocating piston engine were built for heating four two-family houses. Pilot pump operation confirms test rig findings. The service life of rotary piston and reciprocating piston engines was investigated. The tests reveal characteristic curves for reciprocating piston engines and include exhaust composition measurements.

Developing Web-Based Assessment Strategies for Facilitating Junior High School Students to Perform Self-Regulated Learning in an E-Learning Environment

ERIC Educational Resources Information Center

Wang, Tzu-Hua

2011-01-01

This research refers to the self-regulated learning strategies proposed by Pintrich (1999) in developing a multiple-choice Web-based assessment system, the Peer-Driven Assessment Module of the Web-based Assessment and Test Analysis system (PDA-WATA). The major purpose of PDA-WATA is to facilitate learner use of self-regulatory learning behaviors…

Developing Teachers Who Are Reflective Practitioners: A Complex Process

ERIC Educational Resources Information Center

Ostorga, Alcione N.

2006-01-01

Teachers everywhere are being held accountable for their professional actions through the test-driven curricula sweeping the nation. The National Council for the Accreditation of Teacher Education (NCATE, 2002) makes it clear that promotion of reflective practice is an important component of teacher education programs. This multiple case study…

A Theory-Driven Model of Community College Student Engagement

ERIC Educational Resources Information Center

Schuetz, Pam

2008-01-01

This mixed-methods study develops, operationalizes, and tests a new conceptual model of community college student engagement. Themes emerging from participant observations and semistructured interviews with 30 adult students enrolled at a Large Best Practices Community College (LBPCC) over the 2005-2006 academic year are used to guide selection of…

The Pepsi Challenge: Building a Leader-Driven Organization.

ERIC Educational Resources Information Center

Tichy, Noel M.; DeRose, Christopher

1996-01-01

PepsiCo's change-leadership model starts with a teachable point of view, showing trainees how to think in different terms, develop a point of view, test it, crystallize the vision, and implement it. The human resources department plays an important role in articulating the point of view. (SK)

Test Operations Procedure (TOP) 10-2-400 Open End Compressed Gas Driven Shock Tube

DTIC Science & Technology

gas-driven shock tube. Procedures are provided for instrumentation, test item positioning, estimation of key test parameters, operation of the shock...tube, data collection, and reporting. The procedures in this document are based on the use of helium gas and Mylar film diaphragms.

Engineering a self-driven PVDF/PDA hybrid membranes based on membrane micro-reactor effect to achieve super-hydrophilicity, excellent antifouling properties and hemocompatibility

NASA Astrophysics Data System (ADS)

Li, Jian-Hua; Ni, Xing-Xing; Zhang, De-Bin; Zheng, Hui; Wang, Jia-Bin; Zhang, Qi-Qing

2018-06-01

A facile and versatile approach for the preparation of super-hydrophilic, excellent antifouling and hemocompatibility membranes had been developed through the generation in situ of bio-inspired polydopamine (PDA) microspheres on PVDF membranes. SEM images showed that the PDA microspheres were uniformly dispersed on the upper surface and the lower surface of the modified membranes. And there were a great number of PDA microspheres immobilized on the cross-section, but the interconnected pores structure was not destroyed. These facts indicated the existence of membrane micro-reactor effect for the whole membrane structure. Considering the remarkable improvement of hydrophilicity, antifouling properties, and permeation fluxes, we also proposed the cluster phenolic hydroxyl effect for the PVDF/PDA hybrid membranes. And the cluster phenolic hydroxyl effect can be ascribed to the all directions distributed phenolic hydroxyl groups on the whole membrane structure. Besides, the self-driven filtration experiments showed the great wetting ability and permeability of the PVDF/PDA hybrid membranes in filtration process without any external pressure. This implied the existence of accelerating self-driven force after the water flow flowed into the internal of membranes, which contributed to the increase of water flow velocity. All the three aspects were in favor of the enhancement of hydrophilicity, antifouling properties and permeability of the modified membranes. Moreover, the conventional filtration tests, oil/water emulsion filtration tests and protein adsorption tests were also carried out to discuss the practical applications of PVDF/PDA hybrid membranes. And the hemocompatibility of the modified membranes was also proved to enhance greatly through the hemolysis tests and platelet adhesion tests, indicating that the membranes were greatly promising in biomedical applications. The strategy of material modification reported here is substrate-independent and can be extended to other substrate materials, and allows the development of novel functional membranes through secondary treatments.

Is lorazepam-induced amnesia specific to the type of memory or to the task used to assess it?

PubMed

File, S E; Sharma, R; Shaffer, J

1992-01-01

Retrieval tasks can be classified along a continuum from conceptually driven (relying on the encoded meaning of the material) to data driven (relying on the perceptual record and surface features of the material). Since most explicit memory tests are conceptually driven and most implicit memory tests are data driven there has been considerable confounding of the memory system being assessed and the processing required by the retrieval task. The purpose of the present experiment was to investigate the effects of lorazepam on explicit memory, using both types of retrieval task. Lorazepam (2.5 mg) or matched placebo was administered to healthy volunteers and changes in subjective mood ratings and in performance in tests of memory were measured. Lorazepam made subjects significantly more drowsy, feeble, clumsy, muzzy, lethargic and mentally slow. Lorazepam significantly impaired recognition memory for slides, impaired the number of words remembered when the retrieval was cued by the first two letters and reduced the number of pictures remembered when retention was cued with picture fragments. Thus episodic memory was impaired whether the task used was conceptually driven (as in slide recognition) or data driven, as in the other two tasks. Analyses of covariance indicated that the memory impairments were independent of increased sedation, as assessed by self-ratings. In contrast to the deficits in episodic memory, there were no lorazepam-induced impairments in tests of semantic memory, whether this was measured in the conceptually driven task of category generation or in the data-driven task of wordstem completion.

Steady Capillary Driven Flow

NASA Technical Reports Server (NTRS)

Weislogel, Mark M.

1996-01-01

A steady capillary driven flow is developed for a liquid index in a circular tube which is partially coated with a surface modifier to produce a discontinuous wetting condition from one side of the tube to the other. The bulk flow is novel in that it is truly steady, and controlled solely by the physics associated with dynamic wetting. The influence of gravity on the flow is minimized through the use of small diameter tubes approximately O(1 mm) tested horizontally in a laboratory and larger tubes approximately O(10 mm) tested in the low gravity environment of a drop tower. Average steady velocities are predicted and compared against a large experimental data set which includes the effects of tube dimensions and fluid properties. The sensitivity of the velocity to surface cleanliness is dramatic and the advantages of experimentation in a microgravity environment are discussed.

Consensus guidelines for the use of empiric and diagnostic-driven antifungal treatment strategies in haematological malignancy, 2014.

PubMed

Morrissey, C O; Gilroy, N M; Macesic, N; Walker, P; Ananda-Rajah, M; May, M; Heath, C H; Grigg, A; Bardy, P G; Kwan, J; Kirsa, S W; Slavin, M; Gottlieb, T; Chen, S

2014-12-01

Invasive fungal disease (IFD) causes significant morbidity and mortality in patients undergoing allogeneic haemopoietic stem cell transplantation or chemotherapy for haematological malignancy. Much of these adverse outcomes are due to the limited ability of traditional diagnostic tests (i.e. culture and histology) to make an early and accurate diagnosis. As persistent or recurrent fevers of unknown origin (PFUO) in neutropenic patients despite broad-spectrum antibiotics have been associated with the development of IFD, most centres have traditionally administered empiric antifungal therapy (EAFT) to patients with PFUO. However, use of an EAFT strategy has not been shown to have an overall survival benefit and is associated with excessive antifungal therapy use. As a result, the focus has shifted to developing more sensitive and specific diagnostic tests for early and more targeted antifungal treatment. These tests, including the galactomannan enzyme-linked immunosorbent assay and Aspergillus polymerase chain reaction (PCR), have enabled the development of diagnostic-driven antifungal treatment (DDAT) strategies, which have been shown to be safe and feasible, reducing antifungal usage. In addition, the development of effective antifungal prophylactic strategies has changed the landscape in terms of the incidence and types of IFD that clinicians have encountered. In this review, we examine the current role of EAFT and provide up-to-date data on the newer diagnostic tests and algorithms available for use in EAFT and DDAT strategies, within the context of patient risk and type of antifungal prophylaxis used. © 2014 The Authors; Internal Medicine Journal © 2014 Royal Australasian College of Physicians.

Development of a Low Cost High Frequency Pulse Tube Cryocooler

NASA Astrophysics Data System (ADS)

Wang, C.; Caughley, A. J.; Haywood, D. J.

2008-03-01

In cooperation with Industrial Research Ltd (IRL), Cryomech, Inc. is developing a low cost high frequency pulse tube cryocooler. The valveless compressor, developed at IRL, employs two S.S. diaphragms and a novel kinematics driven mechanism. The pulse tube cold head has co-axial configuration. It is separated from the compressor with a SS flexible line of 1 meter long. The test results demonstrate a very small orientation effect of the cold head (<3 K at any orientation). This pulse tube cryocooler provides flexibility for user's integration. It can provide 108W at 77K with an electric input power of 3.7 kW in the primary test.

Activity-Driven CNS Changes in Learning and Development

DTIC Science & Technology

1991-04-14

26 Stimulation of Phosphoinositide Turnover by Excitatory Amino Acids: Pharmacology, Development, and Role in Visual Cortical Plasticity. By...Hz for I sec. Immedi- ately following this tetanic stimulation , the strength of the synaptic connection (as tested with single-shock stimuli...increases up to about 5-fold. Most of this increase decays to a level of about 150-200% of baseline within a few minutes after tetanic stimulation . The early

"¡Cocinar Para Su Salud!" Development of a Culturally Based Nutrition Education Curriculum for Hispanic Breast Cancer Survivors Using a Theory-Driven Procedural Model

ERIC Educational Resources Information Center

Aycinena, Ana Corina; Jennings, Kerri-Ann; Gaffney, Ann Ogden; Koch, Pamela A.; Contento, Isobel R.; Gonzalez, Monica; Guidon, Ela; Karmally, Wahida; Hershman, Dawn; Greenlee, Heather

2017-01-01

We developed a theory-based dietary change curriculum for Hispanic breast cancer survivors with the goal of testing the effects of the intervention on change in dietary intake of fruits/vegetables and fat in a randomized, clinical trial. Social cognitive theory and the transtheoretical model were used as theoretical frameworks to structure…

A cooperative study of gate entry designs: Welbeck Colliery (UK) and Jim Walter Resources (USA)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hendon, G.; Carr, F.; Lewis, A.

1995-11-01

Longwall developments in the UK have historically consisted of single entry gate roads. Adjacent developments were separated from existing pales by large barrier pillars (designed of sufficient width to get away from the longwall abutments of the previous panel) or by small barriers driven in the shadow, or de-stressed zone, of the previous panel. Some 2nd panel tailgates were also driven skin to skin leaving no coal barrier between the newly driven entry and the heavily supported existing gateroad. With the development and wide acceptance of fully bolted entries and the pressure to reduce production costs, alternatives to single entrymore » drivage, particularly yield pillar developments, were examined. Through the Rock Mechanics Branch of british Coal, a cooperative study was begun with Jim Walter Resources, Inc., USA, (JWR) to look at the yield pillar alternative in detail. This study was to determine the feasibility of utilizing yield pillars in the UK and to determine, through monitoring, the possibility of reducing stable pillar widths at JWR. The study has included extensive monitoring of the yield-stable-yield pillar system at JWR No. 7 Mine and an underground trial of a two entry yield pillar test area at Welbeck Colliery in the UK. This paper describes results from the JWR study and the subsequent results of the first advancing yield pillar development in the UK at Welbeck Colliery.« less

Long Duration Hot Hydrogen Exposure of Nuclear Thermal Rocket Materials

NASA Technical Reports Server (NTRS)

Litchford, Ron J.; Foote, John P.; Hickman, Robert; Dobson, Chris; Clifton, Scooter

2007-01-01

An arc-heater driven hyper-thermal convective environments simulator was recently developed and commissioned for long duration hot hydrogen exposure of nuclear thermal rocket materials. This newly established non-nuclear testing capability uses a high-power, multi-gas, wall-stabilized constricted arc-heater to .produce high-temperature pressurized hydrogen flows representative of nuclear reactor core environments, excepting radiation effects, and is intended to serve as a low cost test facility for the purpose of investigating and characterizing candidate fuel/structural materials and improving associated processing/fabrication techniques. Design and engineering development efforts are fully summarized, and facility operating characteristics are reported as determined from a series of baseline performance mapping runs and long duration capability demonstration tests.

Vocabulary Learning Strategies from the Bottom-Up: A Grounded Theory

ERIC Educational Resources Information Center

Ostovar-Namaghi, Seyyed Ali; Malekpur, Akram

2015-01-01

Lots of studies have tried to test the effect of strategy training on vocabulary development. However, instead of trying to uncover the strategies that learners actually use, they have tried to expose learners to a list of strategies supported by theories. Although these theory-driven studies have provided the field with significant and…

Developing a Theory-Driven Model of Community College Student Engagement

ERIC Educational Resources Information Center

Schuetz, Pam

2008-01-01

This article presents a study that uses iterative searches of literature, guided by data from campus observations, interviews, and surveys, to locate and test a theory that can be used to strengthen institutional leverage over student engagement and outcomes. A review of literature was conducted to frame a preliminary theoretical framework for…

Measuring Experiential Avoidance: A Preliminary Test of a Working Model

ERIC Educational Resources Information Center

Hayes, Steven C.; Strosahl, Kirk; Wilson, Kelly G.; Bissett, Richard T.; Pistorello, Jacqueline; Toarmino, Dosheen; Polusny, Melissa A.; Dykstra, Thane A.; Batten, Sonja V.; Bergan, John; Stewart, Sherry H.; Zvolensky, Michael J.; Eifert, Georg H.; Bond, Frank W.; Forsyth, John P.; Karekla, Maria; Mccurry, Susan M.

2004-01-01

The present study describes the development of a short, general measure of experiential avoidance, based on a specific theoretical approach to this process. A theoretically driven iterative exploratory analysis using structural equation modeling on data from a clinical sample yielded a single factor comprising 9 items. A fully confirmatory factor…

ASSESSMENT OF CHEMICAL EFFECTS ON NEURONAL DIFFERENTIATION USING THE ARRAYSCAN HIGH CONTENT SCREENING SYSTEM

EPA Science Inventory

The development of alternative methods for toxicity testing is driven by the need for scientifically valid data that can be obtained in a rapid and cost-efficient manner. In vitro systems provide a model in which chemical effects on cellular events can be examined using technique...

Field instrumentation and testing to study set-up phenomenon of piles driven into Louisiana clayey soils : final report.

DOT National Transportation Integrated Search

2016-07-01

This research study aims to investigate the pile set-up phenomenon for clayey soils and develop empirical models to predict pile set-up : resistance at certain time after end of driving (EOD). To fulfill the objective, a total number of twelve prestr...

Preliminary engineering report for design of a subscale ejector/diffuser system for high expansion ratio space engine testing

NASA Technical Reports Server (NTRS)

Wojciechowski, C. J.; Kurzius, S. C.; Doktor, M. F.

1984-01-01

The design of a subscale jet engine driven ejector/diffuser system is examined. Analytical results and preliminary design drawings and plans are included. Previously developed performance prediction techniques are verified. A safety analysis is performed to determine the mechanism for detonation suppression.

ToxPlorerTM: A Comprehensive Knowledgebase of Toxicity Pathways Using Ontology-driven Information Extraction

EPA Science Inventory

Realizing the potential of pathway-based toxicity testing requires a fresh look at how we describe phenomena leading to adverse effects in vivo, how we assess them in vitro and how we extrapolate them in silico across chemicals, doses and species. We developed the ToxPlorer™ fram...

Automation Hooks Architecture for Flexible Test Orchestration - Concept Development and Validation

NASA Technical Reports Server (NTRS)

Lansdowne, C. A.; Maclean, John R.; Winton, Chris; McCartney, Pat

2011-01-01

The Automation Hooks Architecture Trade Study for Flexible Test Orchestration sought a standardized data-driven alternative to conventional automated test programming interfaces. The study recommended composing the interface using multicast DNS (mDNS/SD) service discovery, Representational State Transfer (Restful) Web Services, and Automatic Test Markup Language (ATML). We describe additional efforts to rapidly mature the Automation Hooks Architecture candidate interface definition by validating it in a broad spectrum of applications. These activities have allowed us to further refine our concepts and provide observations directed toward objectives of economy, scalability, versatility, performance, severability, maintainability, scriptability and others.

Experimental studies of characteristic combustion-driven flows for CFD validation

NASA Technical Reports Server (NTRS)

Santoro, R. J.; Moser, M.; Anderson, W.; Pal, S.; Ryan, H.; Merkle, C. L.

1992-01-01

A series of rocket-related studies intended to develop a suitable data base for validation of Computational Fluid Dynamics (CFD) models of characteristic combustion-driven flows was undertaken at the Propulsion Engineering Research Center at Penn State. Included are studies of coaxial and impinging jet injectors as well as chamber wall heat transfer effects. The objective of these studies is to provide fundamental understanding and benchmark quality data for phenomena important to rocket combustion under well-characterized conditions. Diagnostic techniques utilized in these studies emphasize determinations of velocity, temperature, spray and droplet characteristics, and combustion zone distribution. Since laser diagnostic approaches are favored, the development of an optically accessible rocket chamber has been a high priority in the initial phase of the project. During the design phase for this chamber, the advice and input of the CFD modeling community were actively sought through presentations and written surveys. Based on this procedure, a suitable uni-element rocket chamber was fabricated and is presently under preliminary testing. Results of these tests, as well as the survey findings leading to the chamber design, were presented.

rf improvements for Spallation Neutron Source H- ion sourcea)

NASA Astrophysics Data System (ADS)

Kang, Y. W.; Fuja, R.; Goulding, R. H.; Hardek, T.; Lee, S.-W.; McCarthy, M. P.; Piller, M. C.; Shin, K.; Stockli, M. P.; Welton, R. F.

2010-02-01

The Spallation Neutron Source at Oak Ridge National Laboratory is ramping up the accelerated proton beam power to 1.4 MW and just reached 1 MW. The rf-driven multicusp ion source that originates from the Lawrence Berkeley National Laboratory has been delivering ˜38 mA H- beam in the linac at 60 Hz, 0.9 ms. To improve availability, a rf-driven external antenna multicusp ion source with a water-cooled ceramic aluminum nitride (AlN) plasma chamber is developed. Computer modeling and simulations have been made to analyze and optimize the rf performance of the new ion source. Operational statistics and test runs with up to 56 mA medium energy beam transport beam current identify the 2 MHz rf system as a limiting factor in the system availability and beam production. Plasma ignition system is under development by using a separate 13 MHz system. To improve the availability of the rf power system with easier maintenance, we tested a 70 kV isolation transformer for the 80 kW, 6% duty cycle 2 MHz amplifier to power the ion source from a grounded solid-state amplifier.

rf improvements for Spallation Neutron Source H- ion source.

PubMed

Kang, Y W; Fuja, R; Goulding, R H; Hardek, T; Lee, S-W; McCarthy, M P; Piller, M C; Shin, K; Stockli, M P; Welton, R F

2010-02-01

The Spallation Neutron Source at Oak Ridge National Laboratory is ramping up the accelerated proton beam power to 1.4 MW and just reached 1 MW. The rf-driven multicusp ion source that originates from the Lawrence Berkeley National Laboratory has been delivering approximately 38 mA H(-) beam in the linac at 60 Hz, 0.9 ms. To improve availability, a rf-driven external antenna multicusp ion source with a water-cooled ceramic aluminum nitride (AlN) plasma chamber is developed. Computer modeling and simulations have been made to analyze and optimize the rf performance of the new ion source. Operational statistics and test runs with up to 56 mA medium energy beam transport beam current identify the 2 MHz rf system as a limiting factor in the system availability and beam production. Plasma ignition system is under development by using a separate 13 MHz system. To improve the availability of the rf power system with easier maintenance, we tested a 70 kV isolation transformer for the 80 kW, 6% duty cycle 2 MHz amplifier to power the ion source from a grounded solid-state amplifier.

Moving Towards a Science-Driven Workbench for Earth Science Solutions

NASA Astrophysics Data System (ADS)

Graves, S. J.; Djorgovski, S. G.; Law, E.; Yang, C. P.; Keiser, K.

2017-12-01

The NSF-funded EarthCube Integration and Test Environment (ECITE) prototype was proposed as a 2015 Integrated Activities project and resulted in the prototyping of an EarthCube federated cloud environment and the Integration and Testing Framework. The ECITE team has worked with EarthCube science and technology governance committees to define the types of integration, testing and evaluation necessary to achieve and demonstrate interoperability and functionality that benefit and support the objectives of the EarthCube cyber-infrastructure. The scope of ECITE also includes reaching beyond NSF and EarthCube to work with the broader Earth science community, such as the Earth Science Information Partners (ESIP) to incorporate lessons learned from other testbed activities, and ultimately provide broader community benefits. This presentation will discuss evolving ECITE ideas for a science-driven workbench that will start with documented science use cases, map the use cases to solution scenarios that identify the available technology and data resources that match the use case, the generation of solution workflows and test plans, the testing and evaluation of the solutions in a cloud environment, and finally the documentation of identified technology and data gaps that will assist with driving the development of additional EarthCube resources.

Development of solid tunable optics for ultra-miniature imaging systems

NASA Astrophysics Data System (ADS)

Yongchao, Zou

This thesis focuses on the optimal design, fabrication and testing of solid tunable optics and exploring their applications in miniature imaging systems. It starts with the numerical modelling of such lenses, followed by the optimum design method and alignment tolerance analysis. A miniature solid tunable lens driven by a piezo actuator is then developed. To solve the problem of limited maximum optical power and tuning range in conventional lens designs, a novel multi-element solid tunable lens is proposed and developed. Inspired by the Alvarez principle, a novel miniature solid tunable dual-focus lens, which is designed using freeform surfaces and driven by one micro-electro-mechanical-systems (MEMS) rotary actuator, is demonstrated. To explore the applications of these miniature solid tunable lenses, a miniature adjustable-focus endoscope and one compact adjustable-focus camera module are developed. The adjustable-focus capability of these two miniature imaging systems is fully proved by electrically focusing targets placed at different positions.

Real-time quality monitoring in debutanizer column with regression tree and ANFIS

NASA Astrophysics Data System (ADS)

Siddharth, Kumar; Pathak, Amey; Pani, Ajaya Kumar

2018-05-01

A debutanizer column is an integral part of any petroleum refinery. Online composition monitoring of debutanizer column outlet streams is highly desirable in order to maximize the production of liquefied petroleum gas. In this article, data-driven models for debutanizer column are developed for real-time composition monitoring. The dataset used has seven process variables as inputs and the output is the butane concentration in the debutanizer column bottom product. The input-output dataset is divided equally into a training (calibration) set and a validation (testing) set. The training set data were used to develop fuzzy inference, adaptive neuro fuzzy (ANFIS) and regression tree models for the debutanizer column. The accuracy of the developed models were evaluated by simulation of the models with the validation dataset. It is observed that the ANFIS model has better estimation accuracy than other models developed in this work and many data-driven models proposed so far in the literature for the debutanizer column.

Model-based testing with UML applied to a roaming algorithm for bluetooth devices.

PubMed

Dai, Zhen Ru; Grabowski, Jens; Neukirchen, Helmut; Pals, Holger

2004-11-01

In late 2001, the Object Management Group issued a Request for Proposal to develop a testing profile for UML 2.0. In June 2003, the work on the UML 2.0 Testing Profile was finally adopted by the OMG. Since March 2004, it has become an official standard of the OMG. The UML 2.0 Testing Profile provides support for UML based model-driven testing. This paper introduces a methodology on how to use the testing profile in order to modify and extend an existing UML design model for test issues. The application of the methodology will be explained by applying it to an existing UML Model for a Bluetooth device.

New superconducting cyclotron driven scanning proton therapy systems

NASA Astrophysics Data System (ADS)

Klein, Hans-Udo; Baumgarten, Christian; Geisler, Andreas; Heese, Jürgen; Hobl, Achim; Krischel, Detlef; Schillo, Michael; Schmidt, Stefan; Timmer, Jan

2005-12-01

Since one and a half decades ACCEL is investing in development and engineering of state of the art particle-therapy systems. A new medical superconducting 250 MeV proton cyclotron with special focus on the present and future beam requirements of fast scanning treatment systems has been designed. The first new ACCEL medical proton cyclotron is under commissioning at PSI for their PROSCAN proton therapy facility having undergone successful factory tests especially of the closed loop cryomagnetic system. The second cyclotron is part of ACCEL's integrated proton therapy system for Europe's first clinical center, RPTC in Munich. The cyclotron, the energy selection system, the beamline as well as the four gantries and patient positioners have been installed. The scanning system and major parts of the control software have already been tested. We will report on the concept of ACCEL's superconducting cyclotron driven scanning proton therapy systems and the current status of the commissioning work at PSI and RPTC.

Preliminary research of a novel center-driven robot for upper extremity rehabilitation.

PubMed

Cao, Wujing; Zhang, Fei; Yu, Hongliu; Hu, Bingshan; Meng, Qiaoling

2018-01-19

Loss of upper limb function often appears after stroke. Robot-assisted systems are becoming increasingly common in upper extremity rehabilitation. Rehabilitation robot provides intensive motor therapy, which can be performed in a repetitive, accurate and controllable manner. This study aims to propose a novel center-driven robot for upper extremity rehabilitation. A new power transmission mechanism is designed to transfer the power to elbow and shoulder joints from three motors located on the base. The forward and inverse kinematics equations of the center-driven robot (CENTROBOT) are deduced separately. The theoretical values of the scope of joint movements are obtained with the Denavit-Hartenberg parameters method. A prototype of the CENTROBOT is developed and tested. The elbow flexion/extension, shoulder flexion/extension and shoulder adduction/abduction can be realized of the center-driven robot. The angles value of joints are in conformity with the theoretical value. The CENTROBOT reduces the overall size of the robot arm, the influence of motor noise, radiation and other adverse factors by setting all motors on the base. It can satisfy the requirements of power and movement transmission of the robot arm.

Predicting the stochastic guiding of kinesin-driven microtubules in microfabricated tracks: a statistical-mechanics-based modeling approach.

PubMed

Lin, Chih-Tin; Meyhofer, Edgar; Kurabayashi, Katsuo

2010-01-01

Directional control of microtubule shuttles via microfabricated tracks is key to the development of controlled nanoscale mass transport by kinesin motor molecules. Here we develop and test a model to quantitatively predict the stochastic behavior of microtubule guiding when they mechanically collide with the sidewalls of lithographically patterned tracks. By taking into account appropriate probability distributions of microscopic states of the microtubule system, the model allows us to theoretically analyze the roles of collision conditions and kinesin surface densities in determining how the motion of microtubule shuttles is controlled. In addition, we experimentally observe the statistics of microtubule collision events and compare our theoretical prediction with experimental data to validate our model. The model will direct the design of future hybrid nanotechnology devices that integrate nanoscale transport systems powered by kinesin-driven molecular shuttles.

Static pile load tests on driven piles into Intermediate-Geo Materials.

DOT National Transportation Integrated Search

2016-09-01

The Wisconsin Department of Transportation (WisDOT) has concerns with both predicting pile lengths and pile capacities for H-piles driven into Intermediate-Geo Materials (IGM). The goal of the research was to perform 7 static axial load tests at 7 lo...

Practical experience with test-driven development during commissioning of the multi-star AO system ARGOS

NASA Astrophysics Data System (ADS)

Kulas, M.; Borelli, Jose Luis; Gässler, Wolfgang; Peter, Diethard; Rabien, Sebastian; Orban de Xivry, Gilles; Busoni, Lorenzo; Bonaglia, Marco; Mazzoni, Tommaso; Rahmer, Gustavo

2014-07-01

Commissioning time for an instrument at an observatory is precious, especially the night time. Whenever astronomers come up with a software feature request or point out a software defect, the software engineers have the task to find a solution and implement it as fast as possible. In this project phase, the software engineers work under time pressure and stress to deliver a functional instrument control software (ICS). The shortness of development time during commissioning is a constraint for software engineering teams and applies to the ARGOS project as well. The goal of the ARGOS (Advanced Rayleigh guided Ground layer adaptive Optics System) project is the upgrade of the Large Binocular Telescope (LBT) with an adaptive optics (AO) system consisting of six Rayleigh laser guide stars and wavefront sensors. For developing the ICS, we used the technique Test- Driven Development (TDD) whose main rule demands that the programmer writes test code before production code. Thereby, TDD can yield a software system, that grows without defects and eases maintenance. Having applied TDD in a calm and relaxed environment like office and laboratory, the ARGOS team has profited from the benefits of TDD. Before the commissioning, we were worried that the time pressure in that tough project phase would force us to drop TDD because we would spend more time writing test code than it would be worth. Despite this concern at the beginning, we could keep TDD most of the time also in this project phase This report describes the practical application and performance of TDD including its benefits, limitations and problems during the ARGOS commissioning. Furthermore, it covers our experience with pair programming and continuous integration at the telescope.

New projects developed by COMOTI in gas industry

NASA Astrophysics Data System (ADS)

Nitulescu, Marian; Silivestru, Valentin; Toma, Niculae; Slujitoru, Cristian; Petrescu, Valentin; Leahu, Mihai; Oniga, Ciprian; Ulici, Gheorghe

2015-08-01

The paper aims to present two new projects developed by the Romanian Research and Development Institute for Gas Turbines (COMOTI) in partnership with City University of London and GHH-Rand Germany, in the field of screw compressors/expanders. COMOTI passed, in recent years, from being a GHH-Rand licensed manufacturer for a range of oil-injected screw compressors, of CU type, to a new phase of range diversification, approaching screw compressors with a maximum discharge pressure of 45 bara. So, in cooperation with City University and GHH-Rand we design, manufacture and test, with air, in COMOTI test bench the new type of screw compressor named CHP 220. Also, the cooperation with GHH-Rand has resulted in the design, manufacture and air testing on the test bench, and then gas testing - in a gas compression station - for an electric generator driven by a screw expander. This paper presents how the tests were carried out, the experimental data and the interpretation of results

Bridging the Gap: Linking Simulation and Testing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krajewski, Paul E.; Carsley, John; Stoudt, Mark R.

2012-09-01

The Materials Genome Initiative (MGI) which is a key enabler for the Advanced Manufacturing Partnership, announced in 2011 by U.S. President Barack Obama, was established to accelerate the development and deployment of advanced materials. The MGI is driven by the need to "bridge the gap" between (I) experimental results and computational analysis to enable the rapid development and validation of new mateirals, and (II) the processes required to convert these materials into useable goods.

Laser ignition of an experimental combustion chamber with a multi-injector configuration at low pressure conditions

NASA Astrophysics Data System (ADS)

Börner, Michael; Manfletti, Chiara; Kroupa, Gerhard; Oschwald, Michael

2017-09-01

In search of reliable and light-weight ignition systems for re-ignitable upper stage engines, a laser ignition system was adapted and tested on an experimental combustion chamber for propellant injection into low combustion chamber pressures at 50-80 mbar. The injector head pattern consisted of five coaxial injector elements. Both, laser-ablation-driven ignition and laser-plasma-driven ignition were tested for the propellant combination liquid oxygen and gaseous hydrogen. The 122 test runs demonstrated the reliability of the ignition system for different ignition configurations and negligible degradation due to testing. For the laser-plasma-driven scheme, minimum laser pulse energies needed for 100% ignition probability were found to decrease when increasing the distance of the ignition location from the injector faceplate with a minimum of 2.6 mJ. For laser-ablation-driven ignition, the minimum pulse energy was found to be independent of the ablation material tested and was about 1.7 mJ. The ignition process was characterized using both high-speed Schlieren and OH* emission diagnostics. Based on these findings and on the increased fiber-based pulse transport capabilities recently published, new ignition system configurations for space propulsion systems relying on fiber-based pulse delivery are formulated. If the laser ignition system delivers enough pulse energy, the laser-plasma-driven configuration represents the more versatile configuration. If the laser ignition pulse power is limited, the application of laser-ablation-driven ignition is an option to realize ignition, but implies restrictions concerning the location of ignition.

Subscale Test Methods for Combustion Devices

NASA Technical Reports Server (NTRS)

Anderson, W. E.; Sisco, J. C.; Long, M. R.; Sung, I.-K.

2005-01-01

Stated goals for long-life LRE s have been between 100 and 500 cycles: 1) Inherent technical difficulty of accurately defining the transient and steady state thermochemical environments and structural response (strain); 2) Limited statistical basis on failure mechanisms and effects of design and operational variability; and 3) Very high test costs and budget-driven need to protect test hardware (aversion to test-to-failure). Ambitious goals will require development of new databases: a) Advanced materials, e.g., tailored composites with virtually unlimited property variations; b) Innovative functional designs to exploit full capabilities of advanced materials; and c) Different cycles/operations. Subscale testing is one way to address technical and budget challenges: 1) Prototype subscale combustors exposed to controlled simulated conditions; 2) Complementary to conventional laboratory specimen database development; 3) Instrumented with sensors to measure thermostructural response; and 4) Coupled with analysis

Toward the Replacement of Animal Experiments through the Bioinformatics-driven Analysis of 'Omics' Data from Human Cell Cultures.

PubMed

Grafström, Roland C; Nymark, Penny; Hongisto, Vesa; Spjuth, Ola; Ceder, Rebecca; Willighagen, Egon; Hardy, Barry; Kaski, Samuel; Kohonen, Pekka

2015-11-01

This paper outlines the work for which Roland Grafström and Pekka Kohonen were awarded the 2014 Lush Science Prize. The research activities of the Grafström laboratory have, for many years, covered cancer biology studies, as well as the development and application of toxicity-predictive in vitro models to determine chemical safety. Through the integration of in silico analyses of diverse types of genomics data (transcriptomic and proteomic), their efforts have proved to fit well into the recently-developed Adverse Outcome Pathway paradigm. Genomics analysis within state-of-the-art cancer biology research and Toxicology in the 21st Century concepts share many technological tools. A key category within the Three Rs paradigm is the Replacement of animals in toxicity testing with alternative methods, such as bioinformatics-driven analyses of data obtained from human cell cultures exposed to diverse toxicants. This work was recently expanded within the pan-European SEURAT-1 project (Safety Evaluation Ultimately Replacing Animal Testing), to replace repeat-dose toxicity testing with data-rich analyses of sophisticated cell culture models. The aims and objectives of the SEURAT project have been to guide the application, analysis, interpretation and storage of 'omics' technology-derived data within the service-oriented sub-project, ToxBank. Particularly addressing the Lush Science Prize focus on the relevance of toxicity pathways, a 'data warehouse' that is under continuous expansion, coupled with the development of novel data storage and management methods for toxicology, serve to address data integration across multiple 'omics' technologies. The prize winners' guiding principles and concepts for modern knowledge management of toxicological data are summarised. The translation of basic discovery results ranged from chemical-testing and material-testing data, to information relevant to human health and environmental safety. 2015 FRAME.

A stakeholder-driven approach to improve the informed consent process for palliative chemotherapy.

PubMed

Enzinger, Andrea C; Wind, Jennifer K; Frank, Elizabeth; McCleary, Nadine J; Porter, Laura; Cushing, Heather; Abbott, Caroline; Cronin, Christine; Enzinger, Peter C; Meropol, Neal J; Schrag, Deborah

2017-08-01

Patients often anticipate cure from palliative chemotherapy. Better resources are needed to convey its risks and benefits. We describe the stakeholder-driven development and acceptability testing of a prototype video and companion booklet supporting informed consent (IC) for a common palliative chemotherapy regimen. Our multidisciplinary team (researchers, advocates, clinicians) employed a multistep process of content development, production, critical evaluation, and iterative revisions. Patient/clinician stakeholders were engaged throughout using stakeholder advisory panels, featuring their voices within the intervention, conducting surveys and qualitative interviews. A national panel of 57 patient advocates, and 25 oncologists from nine US practices critiqued the intervention and rated its clarity, accuracy, balance, tone, and utility. Participants also reported satisfaction with existing chemotherapy IC materials. Few oncologists (5/25, 20%) or advocates (10/22, 45%) were satisfied with existing IC materials. In contrast, most rated our intervention highly, with 89-96% agreeing it would be useful and promote informed decisions. Patient voices were considered a key strength. Every oncologist indicated they would use the intervention regularly. Our intervention was acceptable to advocates and oncologists. A randomized trial is evaluating its impact on the chemotherapy IC process. Stakeholder-driven methods can be valuable for developing patient educational interventions. Copyright © 2017 Elsevier B.V. All rights reserved.

Improved design for driven piles based on a pile load test program in Illinois : phase 2.

DOT National Transportation Integrated Search

2014-09-01

A dynamic load test program consisting of 38 sites and 111 piles with restrikes was conducted throughout Illinois : to improve the Illinois Department of Transportation design of driven piling. Pile types included steel H-piles and : closed-ended pip...

A Finite Element Model for Mixed Porohyperelasticity with Transport, Swelling, and Growth.

PubMed

Armstrong, Michelle Hine; Buganza Tepole, Adrián; Kuhl, Ellen; Simon, Bruce R; Vande Geest, Jonathan P

2016-01-01

The purpose of this manuscript is to establish a unified theory of porohyperelasticity with transport and growth and to demonstrate the capability of this theory using a finite element model developed in MATLAB. We combine the theories of volumetric growth and mixed porohyperelasticity with transport and swelling (MPHETS) to derive a new method that models growth of biological soft tissues. The conservation equations and constitutive equations are developed for both solid-only growth and solid/fluid growth. An axisymmetric finite element framework is introduced for the new theory of growing MPHETS (GMPHETS). To illustrate the capabilities of this model, several example finite element test problems are considered using model geometry and material parameters based on experimental data from a porcine coronary artery. Multiple growth laws are considered, including time-driven, concentration-driven, and stress-driven growth. Time-driven growth is compared against an exact analytical solution to validate the model. For concentration-dependent growth, changing the diffusivity (representing a change in drug) fundamentally changes growth behavior. We further demonstrate that for stress-dependent, solid-only growth of an artery, growth of an MPHETS model results in a more uniform hoop stress than growth in a hyperelastic model for the same amount of growth time using the same growth law. This may have implications in the context of developing residual stresses in soft tissues under intraluminal pressure. To our knowledge, this manuscript provides the first full description of an MPHETS model with growth. The developed computational framework can be used in concert with novel in-vitro and in-vivo experimental approaches to identify the governing growth laws for various soft tissues.

Paving the COWpath: data-driven design of pediatric order sets

PubMed Central

Zhang, Yiye; Padman, Rema; Levin, James E

2014-01-01

Objective Evidence indicates that users incur significant physical and cognitive costs in the use of order sets, a core feature of computerized provider order entry systems. This paper develops data-driven approaches for automating the construction of order sets that match closely with user preferences and workflow while minimizing physical and cognitive workload. Materials and methods We developed and tested optimization-based models embedded with clustering techniques using physical and cognitive click cost criteria. By judiciously learning from users’ actual actions, our methods identify items for constituting order sets that are relevant according to historical ordering data and grouped on the basis of order similarity and ordering time. We evaluated performance of the methods using 47 099 orders from the year 2011 for asthma, appendectomy and pneumonia management in a pediatric inpatient setting. Results In comparison with existing order sets, those developed using the new approach significantly reduce the physical and cognitive workload associated with usage by 14–52%. This approach is also capable of accommodating variations in clinical conditions that affect order set usage and development. Discussion There is a critical need to investigate the cognitive complexity imposed on users by complex clinical information systems, and to design their features according to ‘human factors’ best practices. Optimizing order set generation using cognitive cost criteria introduces a new approach that can potentially improve ordering efficiency, reduce unintended variations in order placement, and enhance patient safety. Conclusions We demonstrate that data-driven methods offer a promising approach for designing order sets that are generalizable, data-driven, condition-based, and up to date with current best practices. PMID:24674844

A Finite Element Model for Mixed Porohyperelasticity with Transport, Swelling, and Growth

PubMed Central

Armstrong, Michelle Hine; Buganza Tepole, Adrián; Kuhl, Ellen; Simon, Bruce R.; Vande Geest, Jonathan P.

2016-01-01

The purpose of this manuscript is to establish a unified theory of porohyperelasticity with transport and growth and to demonstrate the capability of this theory using a finite element model developed in MATLAB. We combine the theories of volumetric growth and mixed porohyperelasticity with transport and swelling (MPHETS) to derive a new method that models growth of biological soft tissues. The conservation equations and constitutive equations are developed for both solid-only growth and solid/fluid growth. An axisymmetric finite element framework is introduced for the new theory of growing MPHETS (GMPHETS). To illustrate the capabilities of this model, several example finite element test problems are considered using model geometry and material parameters based on experimental data from a porcine coronary artery. Multiple growth laws are considered, including time-driven, concentration-driven, and stress-driven growth. Time-driven growth is compared against an exact analytical solution to validate the model. For concentration-dependent growth, changing the diffusivity (representing a change in drug) fundamentally changes growth behavior. We further demonstrate that for stress-dependent, solid-only growth of an artery, growth of an MPHETS model results in a more uniform hoop stress than growth in a hyperelastic model for the same amount of growth time using the same growth law. This may have implications in the context of developing residual stresses in soft tissues under intraluminal pressure. To our knowledge, this manuscript provides the first full description of an MPHETS model with growth. The developed computational framework can be used in concert with novel in-vitro and in-vivo experimental approaches to identify the governing growth laws for various soft tissues. PMID:27078495

Understanding How Syntactic Awareness Contributes to Reading Comprehension: Evidence from Mediation and Longitudinal Models

ERIC Educational Resources Information Center

Deacon, S. Hélène; Kieffer, Michael

2018-01-01

The authors tested theoretically driven predictions as to the ways in which syntactic awareness, or awareness of word order within sentences, might contribute to reading comprehension, the end goal of reading development and instruction. They conducted a longitudinal study of 100 English-speaking children followed from Grade 3 to 4. Children…

Experimental Population Genetics in the Introductory Genetics Laboratory Using "Drosophila" as a Model Organism

ERIC Educational Resources Information Center

Johnson, Ronald; Kennon, Tillman

2009-01-01

Hypotheses of population genetics are derived and tested by students in the introductory genetics laboratory classroom as they explore the effects of biotic variables (physical traits of fruit flies) and abiotic variables (island size and distance) on fruit fly populations. In addition to this hypothesis-driven experiment, the development of…

5 Steps to Food Preservation Program Meets the Needs of Idaho Families

ERIC Educational Resources Information Center

Dye, Lorie; Hoffman, Katie

2014-01-01

University of Idaho FCS Extension Educators in southeastern Idaho developed a five-lesson condensed version of safe food preservation classes, driven by participants' interest to meet the needs of everyday home preservers. A post-test survey revealed that participants took the course to be self-reliant, use their own produce, and be in control of…

Development Testing and Subsequent Failure Investigation of a Spring Strut Mechanism

NASA Technical Reports Server (NTRS)

Dervan, Jared; Robertson, Brandon; Staab, Lucas; Culberson, Michael

2014-01-01

Commodities are transferred between the Multi-Purpose Crew Vehicle (MPCV) crew module (CM) and service module (SM) via an external umbilical that is driven apart with spring-loaded struts after the structural connection is severed. The spring struts must operate correctly for the modules to separate safely. There was no vibration testing of strut development units scoped in the MPCV Program Plan; therefore, any design problems discovered as a result of vibration testing would not have been found until the component qualification. The NASA Engineering and Safety Center (NESC) and Lockheed Martin (LM) performed random vibration testing on a single spring strut development unit to assess its ability to withstand qualification level random vibration environments. Failure of the strut while exposed to random vibration resulted in a follow-on failure investigation, design changes, and additional development tests. This paper focuses on the results of the failure investigations including identified lessons learned and best practices to aid in future design iterations of the spring strut and to help other mechanism developers avoid similar pitfalls.

The Shock and Vibration Bulletin. Part 1. Invited Papers, Submarine Shock Testing, Shock Analysis, Shock Testing

DTIC Science & Technology

1973-06-01

approximately 4. Use of a cold gas for determining was determined and presented in Figure 3. This analysis was unsteady flow characteristics and...driven by a hydraulic motor. shown experimentally that drawbar force re- Roller motion develops a high rotating force , ductions greater than one part in...of doors, a water table flow bient pressure. The interest in determining this decay time is analogy was used. With this analogy, a two-dimensional

Preliminary design and development of a reflectance spectrometer instrument

NASA Technical Reports Server (NTRS)

Mccord, T. B.

1979-01-01

An improved design for the reflectance spectrometer is described to be used on various terrestrial body missions. These improvements were made on the original Lunar Polar Orbiter design. These include a larger entrance mirror, rectangular aperture, multiple optical beams, spatial resolution, and a bandwidth extension to 5 microns. In addition, detailed electronic designs were produced for a charge amplifier and an amplifier/demodulator/integrator. Design of a microprocessor driven test system was begun. Laboratory tests were performed on a tuning fork chopper.

Development and testing of a novel survey to assess Stakeholder-driven Community Diffusion of childhood obesity prevention efforts.

PubMed

Korn, Ariella R; Hennessy, Erin; Hammond, Ross A; Allender, Steven; Gillman, Matthew W; Kasman, Matt; McGlashan, Jaimie; Millar, Lynne; Owen, Brynle; Pachucki, Mark C; Swinburn, Boyd; Tovar, Alison; Economos, Christina D

2018-05-31

Involving groups of community stakeholders (e.g., steering committees) to lead community-wide health interventions appears to support multiple outcomes ranging from policy and systems change to individual biology. While numerous tools are available to measure stakeholder characteristics, many lack detail on reliability and validity, are not context specific, and may not be sensitive enough to capture change over time. This study describes the development and reliability of a novel survey to measure Stakeholder-driven Community Diffusion via assessment of stakeholders' social networks, knowledge, and engagement about childhood obesity prevention. This study was completed in three phases. Phase 1 included conceptualization and online survey development through literature reviews and expert input. Phase 2 included a retrospective study with stakeholders from two completed whole-of-community interventions. Between May-October 2015, 21 stakeholders from the Shape Up Somerville and Romp & Chomp interventions recalled their social networks, knowledge, and engagement pre-post intervention. We also assessed one-week test-retest reliability of knowledge and engagement survey modules among Shape Up Somerville respondents. Phase 3 included survey modifications and a second prospective reliability assessment. Test-retest reliability was assessed in May 2016 among 13 stakeholders involved in ongoing interventions in Victoria, Australia. In Phase 1, we developed a survey with 7, 20 and 50 items for the social networks, knowledge, and engagement survey modules, respectively. In the Phase 2 retrospective study, Shape Up Somerville and Romp & Chomp networks included 99 and 54 individuals. Pre-post Shape Up Somerville and Romp & Chomp mean knowledge scores increased by 3.5 points (95% CI: 0.35-6.72) and (- 0.42-7.42). Engagement scores did not change significantly (Shape Up Somerville: 1.1 points (- 0.55-2.73); Romp & Chomp: 0.7 points (- 0.43-1.73)). Intraclass correlation coefficients (ICCs) for knowledge and engagement were 0.88 (0.67-0.97) and 0.97 (0.89-0.99). In Phase 3, the modified knowledge and engagement survey modules included 18 and 25 items, respectively. Knowledge and engagement ICCs were 0.84 (0.62-0.95) and 0.58 (0.23-0.86). The survey measures upstream stakeholder properties-social networks, knowledge, and engagement-with good test-retest reliability. Future research related to Stakeholder-driven Community Diffusion should focus on prospective change and survey validation for intervention effectiveness.

Lockheed Martin approach to a Reusable Launch Vehicle (RLV)

NASA Astrophysics Data System (ADS)

Elvin, John D.

1996-03-01

This paper discusses Lockheed Martin's perspective on the development of a cost effective Reusable Launch Vehicle (RLV). Critical to a successful Single Stage To Orbit (SSTO) program are; an economic development plan sensitive to fiscal constraints; a vehicle concept satisfying present and future US launch needs; and an operations concept commensurate with a market driven program. Participation in the economic plan by government, industry, and the commercial sector is a key element of integrating our development plan and funding profile. The RLV baseline concept design, development evolution and several critical trade studies illustrate the superior performance achieved by our innovative approach to the problem of SSTO. Findings from initial aerodynamic and aerothermodynamic wind tunnel tests and trajectory analyses on this concept confirm the superior characteristics of the lifting body shape combined with the Linear Aerospike rocket engine. This Aero Ballistic Rocket (ABR) concept captures the essence of The Skunk Works approach to SSTO RLV technology integration and system engineering. These programmatic and concept development topics chronicle the key elements to implementing an innovative market driven next generation RLV.

Development progresses of radio frequency ion source for neutral beam injector in fusion devices.

PubMed

Chang, D H; Jeong, S H; Kim, T S; Park, M; Lee, K W; In, S R

2014-02-01

A large-area RF (radio frequency)-driven ion source is being developed in Germany for the heating and current drive of an ITER device. Negative hydrogen ion sources are the major components of neutral beam injection systems in future large-scale fusion experiments such as ITER and DEMO. RF ion sources for the production of positive hydrogen (deuterium) ions have been successfully developed for the neutral beam heating systems at IPP (Max-Planck-Institute for Plasma Physics) in Germany. The first long-pulse ion source has been developed successfully with a magnetic bucket plasma generator including a filament heating structure for the first NBI system of the KSTAR tokamak. There is a development plan for an RF ion source at KAERI to extract the positive ions, which can be applied for the KSTAR NBI system and to extract the negative ions for future fusion devices such as the Fusion Neutron Source and Korea-DEMO. The characteristics of RF-driven plasmas and the uniformity of the plasma parameters in the test-RF ion source were investigated initially using an electrostatic probe.

Prediction of the interior noise levels of high-speed propeller-driven aircraft

NASA Technical Reports Server (NTRS)

Rennison, D. C.; Wilby, J. F.; Wilby, E. G.

1980-01-01

The theoretical basis for an analytical model developed to predict the interior noise levels of high-speed propeller-driven airplanes is presented. Particular emphasis is given to modeling the transmission of discrete tones through a fuselage element into a cavity, estimates for the mean and standard deviation of the acoustic power flow, the coupling between a non-homogeneous excitation and the fuselage vibration response, and the prediction of maximum interior noise levels. The model allows for convenient examination of the various roles of the excitation and fuselage structural characteristics on the fuselage vibration response and the interior noise levels, as is required for the design of model or prototype noise control validation tests.

An optimized strain demodulation method for PZT driven fiber Fabry-Perot tunable filter

NASA Astrophysics Data System (ADS)

Sheng, Wenjuan; Peng, G. D.; Liu, Yang; Yang, Ning

2015-08-01

An optimized strain-demodulation-method based on piezo-electrical transducer (PZT) driven fiber Fabry-Perot (FFP) filter is proposed and experimentally demonstrated. Using a parallel processing mode to drive the PZT continuously, the hysteresis effect is eliminated, and the system demodulation rate is increased. Furthermore, an AC-DC compensation method is developed to address the intrinsic nonlinear relationship between the displacement and voltage of PZT. The experimental results show that the actual demodulation rate is improved from 15 Hz to 30 Hz, the random error of the strain measurement is decreased by 95%, and the deviation between the test values after compensation and the theoretical values is less than 1 pm/με.

Dispersive Readout of Adiabatic Phases

NASA Astrophysics Data System (ADS)

Kohler, Sigmund

2017-11-01

We propose a protocol for the measurement of adiabatic phases of periodically driven quantum systems coupled to an open cavity that enables dispersive readout. It turns out that the cavity transmission exhibits peaks at frequencies determined by a resonance condition that involves the dynamical and the geometric phase. Since these phases scale differently with the driving frequency, one can determine them by fitting the peak positions to the theoretically expected behavior. For the derivation of the resonance condition and for a numerical study, we develop a Floquet theory for the dispersive readout of ac driven quantum systems. The feasibility is demonstrated for two test cases that generalize Landau-Zener-Stückelberg-Majorana interference to two-parameter driving.

Modelling of piezoelectric actuator dynamics for active structural control

NASA Technical Reports Server (NTRS)

Hagood, Nesbitt W.; Chung, Walter H.; Von Flotow, Andreas

1990-01-01

The paper models the effects of dynamic coupling between a structure and an electrical network through the piezoelectric effect. The coupled equations of motion of an arbitrary elastic structure with piezoelectric elements and passive electronics are derived. State space models are developed for three important cases: direct voltage driven electrodes, direct charge driven electrodes, and an indirect drive case where the piezoelectric electrodes are connected to an arbitrary electrical circuit with embedded voltage and current sources. The equations are applied to the case of a cantilevered beam with surface mounted piezoceramics and indirect voltage and current drive. The theoretical derivations are validated experimentally on an actively controlled cantilevered beam test article with indirect voltage drive.

Field instrumentation and testing to study set-up phenomenon of piles driven into Louisiana clayey soils.

DOT National Transportation Integrated Search

2011-02-01

The main objective of this research study is to evaluate the time-dependent increase in pile capacity (or pile setup phenomenon) for piles driven into Louisiana soils through conducting repeated static and dynamic field testing with time on full-scal...

Development of high intensity ion sources for a Tandem-Electrostatic-Quadrupole facility for Accelerator-Based Boron Neutron Capture Therapy.

PubMed

Bergueiro, J; Igarzabal, M; Sandin, J C Suarez; Somacal, H R; Vento, V Thatar; Huck, H; Valda, A A; Repetto, M; Kreiner, A J

2011-12-01

Several ion sources have been developed and an ion source test stand has been mounted for the first stage of a Tandem-Electrostatic-Quadrupole facility For Accelerator-Based Boron Neutron Capture Therapy. A first source, designed, fabricated and tested is a dual chamber, filament driven and magnetically compressed volume plasma proton ion source. A 4 mA beam has been accelerated and transported into the suppressed Faraday cup. Extensive simulations of the sources have been performed using both 2D and 3D self-consistent codes. Copyright © 2011 Elsevier Ltd. All rights reserved.

Performance of the Southern California Edison Company Stirling dish

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lopez, C.W.; Stone, K.W.

1993-10-01

McDonnell Douglas Astronautics Company (MDAC) and United Stirling AB of Sweden (USAB) formed a joint venture in 1982 to develop and produce a Stirling dish solar generating system. In this report, the six year development and testing program continued by the Southern California Edison Company (SCE) is described. Each Stirling dish module consists of a sun tracking dish concentrator developed by the MDAC and a Stirling engine driven power conversion unit (PCU) developed by USAB. The Stirling dish system demonstrated twice the peak and daily solar-to-electric conversion efficiency of any other system then under development. This system continues to setmore » the performance standard for solar to electric systems being developed in the early 1990`s. Test data are presented and used to estimate the performance of a commercial system.« less

The effects of time on the capacity of pipe piles in dense marine sand

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chow, F.C.; Jardine, R.J.; Brucy, F.

Investigations into pile behavior in dense marine sand have been performed by IFP and IC at Dunkirk, North France. In the most recent series of tests, strain-gauged, open-ended pipe piles, driven and statically load tested in 1989, were retested in 1994. Surprisingly large increases in shaft capacity were measured. The possible causes are evaluated in relation to previous case histories, laboratory soil tests, pile corrosion and new effective stress analyses developed using smaller, more intensively instrumented piles. The shaft capacities predicted by existing design methods are also assessed. 51 refs., 12 figs., 4 tabs.

Baseline automotive gas turbine engine development program

NASA Technical Reports Server (NTRS)

Wagner, C. E. (Editor); Pampreen, R. C. (Editor)

1979-01-01

Tests results on a baseline engine are presented to document the automotive gas turbine state-of-the-art at the start of the program. The performance characteristics of the engine and of a vehicle powered by this engine are defined. Component improvement concepts in the baseline engine were evaluated on engine dynamometer tests in the complete vehicle on a chassis dynamometer and on road tests. The concepts included advanced combustors, ceramic regenerators, an integrated control system, low cost turbine material, a continuously variable transmission, power-turbine-driven accessories, power augmentation, and linerless insulation in the engine housing.

Watershed Watch: The Importance of Mentors in Student-driven Full Inquiry Undergraduate Research Projects as the Foundation for an Introductory Course in Biogeoscience

NASA Astrophysics Data System (ADS)

Rock, B. N.; Hale, S. R.; Graham, K. J.; Hayden, L.; Barber, L.; Perry, C.; Schloss, J.; Sullivan, E.; Yuan, J.; Abebe, E.; Mitchell, L.; Abrams, E.; Gagnon, M.

2008-12-01

Watershed Watch (NSF 0525433) engages early undergraduate students from two-year and four-year colleges in student-driven full inquiry-based instruction in the biogeosciences. Program goals for Watershed Watch are to test if inquiry-rich student-driven projects sufficiently engage undeclared students (or noncommittal STEM majors) to declare a STEM major (or remain with their STEM major). A significant component of this program is an intensive two-week Summer course, in which undeclared freshmen research various aspects of a local watershed. Students develop their own research questions and study design, collect and analyze data, and produce a scientific or an oral poster presentation. The course objectives, curriculum and schedule are presented as a model for dissemination for other institutions and programs seeking to develop inquiry-rich courses designed to attract students into biogeoscience disciplines. Data from self-reported student feedback indicated the most important factors explaining high-levels of student motivation and research excellence in the course are 1) working with committed, energetic, and enthusiastic faculty mentors; and 2) faculty mentors demonstrating high degrees of teamwork and coordination.

Impact of a clinical guideline for prescribing antibiotics to inpatients reporting penicillin or cephalosporin allergy.

PubMed

Blumenthal, Kimberly G; Shenoy, Erica S; Varughese, Christy A; Hurwitz, Shelley; Hooper, David C; Banerji, Aleena

2015-10-01

Self-reported penicillin allergy infrequently reflects an inability to tolerate penicillins. Inpatients reporting penicillin allergy receive alternative antibiotics that might be broader spectrum, more toxic, or less effective. To develop and assess a clinical guideline for the general inpatient provider that directs taking a history and prescribing antibiotics for patients with penicillin or cephalosporin allergy. A guideline was implemented to assist providers with assessing allergy history and prescribing antibiotics for patients with reported penicillin or cephalosporin allergy. The guideline used a standard 2-step graded challenge or test dose. A quasi-experimental study was performed to assess safety, feasibility, and impact on antibiotic use by comparing treatment 21 months before guideline implementation with 12 months after guideline implementation. Significantly more test doses to β-lactam antibiotics were performed monthly after vs before guideline implementation (median 14.5, interquartile range 13-16.25, vs 2, interquartile range 1-3.25, P < .001). Seven adverse drug reactions occurred during guideline-driven test doses, with no significant difference in rate (3.9% vs 6.1%, P = .44) or severity (P > .5) between periods. Guideline-driven test doses decreased alternative antimicrobial therapy after the test dose, including vancomycin (68.3% vs 37.2%, P < .001), aztreonam (11.5% vs 0.5%, P < .001), aminoglycosides (6.0% vs 1.1%, P = .004), and fluoro quinolones (15.3% vs 3.3%, P < .001). The implementation of an inpatient antibiotic prescribing guideline for patients with penicillin or cephalosporin allergy was associated with an almost 7-fold increase in the number of test doses to β-lactams without increased adverse drug reactions. Patients assessed with guideline-driven test doses were observed to have significantly decreased alternative antibiotic exposure. Copyright © 2015 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Development of a small specimen test machine to evaluate irradiation embrittlement of fusion reactor materials

NASA Astrophysics Data System (ADS)

Ishii, T.; Ohmi, M.; Saito, J.; Hoshiya, T.; Ooka, N.; Jitsukawa, S.; Eto, M.

2000-12-01

Small specimen test techniques (SSTT) are essential to use an accelerator-driven deuterium-lithium stripping reaction neutron source for the study of fusion reactor materials because of the limitation of the available irradiation volume. A remote-controlled small punch (SP) test machine was developed at the hot laboratory of the Japan Materials Testing Reactor (JMTR) in the Japan Atomic Energy Research Institute (JAERI). This report describes the SP test method and machine for use in a hot cell, and test results on irradiated ferritic steels. The specimen was either a coupon 10×10×0.25 mm 3 or a TEM disk 3 mm in diameter by 0.25 mm in thickness. Tests can be performed at temperatures ranging from 93 to 1123 K in a vacuum or in an inert gas environment. The ductile to brittle transition temperature of the irradiated ferritic steel as determined by the SP test is also evaluated.

A test matrix sequencer for research test facility automation

NASA Technical Reports Server (NTRS)

Mccartney, Timothy P.; Emery, Edward F.

1990-01-01

The hardware and software configuration of a Test Matrix Sequencer, a general purpose test matrix profiler that was developed for research test facility automation at the NASA Lewis Research Center, is described. The system provides set points to controllers and contact closures to data systems during the course of a test. The Test Matrix Sequencer consists of a microprocessor controlled system which is operated from a personal computer. The software program, which is the main element of the overall system is interactive and menu driven with pop-up windows and help screens. Analog and digital input/output channels can be controlled from a personal computer using the software program. The Test Matrix Sequencer provides more efficient use of aeronautics test facilities by automating repetitive tasks that were once done manually.

Full load shop testing of 18,000-hp gas turbine driven centrifugal compressor for offshore platform service: Evaluation of rotor dynamics performance

NASA Technical Reports Server (NTRS)

Kirk, R. G.; Simpson, M.

1985-01-01

The results for in-plant full load testing of a 13.4 MW (18000 HP) gas turbine driven centrifugal compressor are presented and compared to analytical predictions of compressor rotor stability. Unique problems from both oil seals and labyrinth gas seals were encountered during the testing. The successful resolution of these problems are summarized.

Seismology software: state of the practice

NASA Astrophysics Data System (ADS)

Smith, W. Spencer; Zeng, Zheng; Carette, Jacques

2018-05-01

We analyzed the state of practice for software development in the seismology domain by comparing 30 software packages on four aspects: product, implementation, design, and process. We found room for improvement in most seismology software packages. The principal areas of concern include a lack of adequate requirements and design specification documents, a lack of test data to assess reliability, a lack of examples to get new users started, and a lack of technological tools to assist with managing the development process. To assist going forward, we provide recommendations for a document-driven development process that includes a problem statement, development plan, requirement specification, verification and validation (V&V) plan, design specification, code, V&V report, and a user manual. We also provide advice on tool use, including issue tracking, version control, code documentation, and testing tools.

Seismology software: state of the practice

NASA Astrophysics Data System (ADS)

Smith, W. Spencer; Zeng, Zheng; Carette, Jacques

2018-02-01

We analyzed the state of practice for software development in the seismology domain by comparing 30 software packages on four aspects: product, implementation, design, and process. We found room for improvement in most seismology software packages. The principal areas of concern include a lack of adequate requirements and design specification documents, a lack of test data to assess reliability, a lack of examples to get new users started, and a lack of technological tools to assist with managing the development process. To assist going forward, we provide recommendations for a document-driven development process that includes a problem statement, development plan, requirement specification, verification and validation (V&V) plan, design specification, code, V&V report, and a user manual. We also provide advice on tool use, including issue tracking, version control, code documentation, and testing tools.

Rage against the machine? Google's self-driving cars versus human drivers.

PubMed

Teoh, Eric R; Kidd, David G

2017-12-01

Automated driving represents both challenges and opportunities in highway safety. Google has been developing self-driving cars and testing them under employee supervision on public roads since 2009. These vehicles have been involved in several crashes, and it is of interest how this testing program compares to human drivers in terms of safety. Google car crashes were coded by type and severity based on narratives released by Google. Crash rates per million vehicle miles traveled (VMT) were computed for crashes deemed severe enough to be reportable to police. These were compared with police-reported crash rates for human drivers. Crash types also were compared. Google cars had a much lower rate of police-reportable crashes per million VMT than human drivers in Mountain View, Calif., during 2009-2015 (2.19 vs 6.06), but the difference was not statistically significant. The most common type of collision involving Google cars was when they got rear-ended by another (human-driven) vehicle. Google cars shared responsibility for only one crash. These results suggest Google self-driving cars, while a test program, are safer than conventional human-driven passenger vehicles; however, currently there is insufficient information to fully examine the extent to which disengagements affected these results. Results suggest that highly-automated vehicles can perform more safely than human drivers in certain conditions, but will continue to be involved in crashes with conventionally-driven vehicles. Copyright © 2017. Published by Elsevier Ltd.

Development of a design basis tornado and structural design criteria for the Nevada Test Site, Nevada. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

McDonald, J.R.; Minor, J.E.; Mehta, K.C.

1975-06-01

In order to evaluate the ability of critical facilities at the Nevada Test Site to withstand the possible damaging effects of extreme winds and tornadoes, parameters for the effects of tornadoes and extreme winds and structural design criteria for the design and evaluation of structures were developed. The meteorological investigations conducted are summarized, and techniques used for developing the combined tornado and extreme wind risk model are discussed. The guidelines for structural design include methods for calculating pressure distributions on walls and roofs of structures and methods for accommodating impact loads from wind-driven missiles. Calculations for determining the design loadsmore » for an example structure are included. (LCL)« less

Efficacy of laser-driven irrigation versus ultrasonic in removing an airlock from the apical third of a narrow root canal.

PubMed

Peeters, Harry Huiz; Gutknecht, Norbert

2014-08-01

The purpose of the study was to test the hypothesis that air entrapment occurs in the apical third of a root canal during irrigation. A second objective was to test the null hypothesis that there is no difference between laser-driven irrigation (an erbium, chromium:yttrium-scandium-gallium-garnet laser) and passive ultrasonic irrigation in removing an airlock from the apical third. One hundred twenty extracted human teeth with single narrow root canals were randomised into two experimental groups (n = 40) and two control groups (n = 20). The specimens were shaped using hand instruments up to a size 30/0.02 file. The teeth were irrigated with a mixture of saline, radiopaque contrast and ink in solution. In the passive ultrasonic irrigation group, the irrigant was activated with an ultrasonic device for 60 s. In the laser group, the irrigant was activated with a laser for 60 s. It was concluded that if the insertion of irrigation needle is shorter than the working length, air entrapment may develop in the apical third, but the use of laser-driven irrigation is completely effective in removing it. © 2013 The Authors. Australian Endodontic Journal © 2013 Australian Society of Endodontology.

How and when Does Complex Reasoning Occur? Empirically Driven Development of a Learning Progression Focused on Complex Reasoning about Biodiversity

ERIC Educational Resources Information Center

Songer, Nancy Butler; Kelcey, Ben; Gotwals, Amelia Wenk

2009-01-01

In order to compete in a global economy, students are going to need resources and curricula focusing on critical thinking and reasoning in science. Despite awareness for the need for complex reasoning, American students perform poorly relative to peers on international standardized tests measuring complex thinking in science. Research focusing on…

Keeping Learning on Track: A Case-Study of Formative Assessment Practice and Its Impact on Learning in Meridian School District

ERIC Educational Resources Information Center

Thum, Y. M.; Tarasawa, B.; Hegedus, A.; Yun, X.; Bowe, B.

2015-01-01

In partnership with Joint School District 2 in Meridian, Idaho, this theory-driven study assessed the impact of Keeping Learning on Track® (KLT™), a professional development program pioneered by Dylan Wiliam and his colleagues at the Educational Testing Service (ETS). A team of Northwest Evaluation Association™ (NWEA™) researchers surveyed…

A Comprehensive Analysis of High School Genetics Standards: Are States Keeping Pace with Modern Genetics?

ERIC Educational Resources Information Center

Dougherty, M. J.; Pleasants, C.; Solow, L.; Wong, A.; Zhang, H.

2011-01-01

Science education in the United States will increasingly be driven by testing and accountability requirements, such as those mandated by the No Child Left Behind Act, which rely heavily on learning outcomes, or "standards," that are currently developed on a state-by-state basis. Those standards, in turn, drive curriculum and instruction.…

Revel8or: Model Driven Capacity Planning Tool Suite

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhu, Liming; Liu, Yan; Bui, Ngoc B.

2007-05-31

Designing complex multi-tier applications that must meet strict performance requirements is a challenging software engineering problem. Ideally, the application architect could derive accurate performance predictions early in the project life-cycle, leveraging initial application design-level models and a description of the target software and hardware platforms. To this end, we have developed a capacity planning tool suite for component-based applications, called Revel8tor. The tool adheres to the model driven development paradigm and supports benchmarking and performance prediction for J2EE, .Net and Web services platforms. The suite is composed of three different tools: MDAPerf, MDABench and DSLBench. MDAPerf allows annotation of designmore » diagrams and derives performance analysis models. MDABench allows a customized benchmark application to be modeled in the UML 2.0 Testing Profile and automatically generates a deployable application, with measurement automatically conducted. DSLBench allows the same benchmark modeling and generation to be conducted using a simple performance engineering Domain Specific Language (DSL) in Microsoft Visual Studio. DSLBench integrates with Visual Studio and reuses its load testing infrastructure. Together, the tool suite can assist capacity planning across platforms in an automated fashion.« less

Stress redistribution and damage in interconnects caused by electromigration

NASA Astrophysics Data System (ADS)

Chiras, Stefanie Ruth

Electromigration has long been recognized as a phenomenon that induces mass redistribution in metals which, when constrained, can lead to the creation of stress. Since the development of the integrated circuit, electromigration. in interconnects, (the metal lines which carry current between devices in integrated circuits), has become a reliability concern. The primary failure mechanism in the interconnects is usually voiding, which causes electrical resistance increases in the circuit. In some cases, however, another failure mode occurs, fracture of the surrounding dielectric driven by electromigration induced compressive stresses within the interconnect. It is this failure mechanism that is the focus of this thesis. To study dielectric fracture, both residual processing stresses and the development of electromigration induced stress in isolated, constrained interconnects was measured. The high-resolution measurements were made using two types of piezospectroscopy, complemented by finite element analysis (FEA). Both procedures directly measured stress in the underlying or neighboring substrate and used FEA to determine interconnect stresses. These interconnect stresses were related to the effected circuit failure mode through post-test scanning electron microscopy and resistance measurements taken during electromigration testing. The results provide qualitative evidence of electromigration driven passivation fracture, and quantitative analysis of the theoretical model of the failure, the "immortal" interconnect concept.

Dwell Notch Low Cycle Fatigue Behavior of a Powder Metallurgy Nickel Disk Alloy

NASA Technical Reports Server (NTRS)

Telesman, J.; Gabb, T. P.; Yamada, Y.; Ghosn, L. J.; Jayaraman, N.

2012-01-01

A study was conducted to determine the processes which govern dwell notch low cycle fatigue (NLCF) behavior of a powder metallurgy (P/M) ME3 disk superalloy. The emphasis was placed on the environmentally driven mechanisms which may embrittle the highly stressed notch surface regions and reduce NLCF life. In conjunction with the environmentally driven notch surface degradation processes, the visco-plastic driven mechanisms which can significantly change the notch root stresses were also considered. Dwell notch low cycle fatigue testing was performed in air and vacuum on a ME3 P/M disk alloy specimens heat treated using either a fast or a slow cooling rate from the solutioning treatment. It was shown that dwells at the minimum stress typically produced a greater life debit than the dwells applied at the maximum stress, especially for the slow cooled heat treatment. Two different environmentally driven failure mechanisms were identified as the root cause of early crack initiation in the min dwell tests. Both of these failure mechanisms produced mostly a transgranular crack initiation failure mode and yet still resulted in low NLCF fatigue lives. The lack of stress relaxation during the min dwell tests produced higher notch root stresses which caused early crack initiation and premature failure when combined with the environmentally driven surface degradation mechanisms. The importance of environmental degradation mechanisms was further highlighted by vacuum dwell NLCF tests which resulted in considerably longer NLCF lives, especially for the min dwell tests.

Hyperthermal Environments Simulator for Nuclear Rocket Engine Development

NASA Technical Reports Server (NTRS)

Litchford, Ron J.; Foote, John P.; Clifton, W. B.; Hickman, Robert R.; Wang, Ten-See; Dobson, Christopher C.

2011-01-01

An arc-heater driven hyperthermal convective environments simulator was recently developed and commissioned for long duration hot hydrogen exposure of nuclear thermal rocket materials. This newly established non-nuclear testing capability uses a high-power, multi-gas, wall-stabilized constricted arc-heater to produce hightemperature pressurized hydrogen flows representative of nuclear reactor core environments, excepting radiation effects, and is intended to serve as a low-cost facility for supporting non-nuclear developmental testing of hightemperature fissile fuels and structural materials. The resulting reactor environments simulator represents a valuable addition to the available inventory of non-nuclear test facilities and is uniquely capable of investigating and characterizing candidate fuel/structural materials, improving associated processing/fabrication techniques, and simulating reactor thermal hydraulics. This paper summarizes facility design and engineering development efforts and reports baseline operational characteristics as determined from a series of performance mapping and long duration capability demonstration tests. Potential follow-on developmental strategies are also suggested in view of the technical and policy challenges ahead. Keywords: Nuclear Rocket Engine, Reactor Environments, Non-Nuclear Testing, Fissile Fuel Development.

An ontology-driven, diagnostic modeling system.

PubMed

Haug, Peter J; Ferraro, Jeffrey P; Holmen, John; Wu, Xinzi; Mynam, Kumar; Ebert, Matthew; Dean, Nathan; Jones, Jason

2013-06-01

To present a system that uses knowledge stored in a medical ontology to automate the development of diagnostic decision support systems. To illustrate its function through an example focused on the development of a tool for diagnosing pneumonia. We developed a system that automates the creation of diagnostic decision-support applications. It relies on a medical ontology to direct the acquisition of clinic data from a clinical data warehouse and uses an automated analytic system to apply a sequence of machine learning algorithms that create applications for diagnostic screening. We refer to this system as the ontology-driven diagnostic modeling system (ODMS). We tested this system using samples of patient data collected in Salt Lake City emergency rooms and stored in Intermountain Healthcare's enterprise data warehouse. The system was used in the preliminary development steps of a tool to identify patients with pneumonia in the emergency department. This tool was compared with a manually created diagnostic tool derived from a curated dataset. The manually created tool is currently in clinical use. The automatically created tool had an area under the receiver operating characteristic curve of 0.920 (95% CI 0.916 to 0.924), compared with 0.944 (95% CI 0.942 to 0.947) for the manually created tool. Initial testing of the ODMS demonstrates promising accuracy for the highly automated results and illustrates the route to model improvement. The use of medical knowledge, embedded in ontologies, to direct the initial development of diagnostic computing systems appears feasible.

Embedding Agile Practices within a Plan-Driven Hierarchical Project Life Cycle

DOE Office of Scientific and Technical Information (OSTI.GOV)

Millard, W. David; Johnson, Daniel M.; Henderson, John M.

2014-07-28

Organizations use structured, plan-driven approaches to provide continuity, direction, and control to large, multi-year programs. Projects within these programs vary greatly in size, complexity, level of maturity, technical risk, and clarity of the development objectives. Organizations that perform exploratory research, evolutionary development, and other R&D activities can obtain the benefits of Agile practices without losing the benefits of their program’s overarching plan-driven structure. This paper describes application of Agile development methods on a large plan-driven sensor integration program. While the client employed plan-driven, requirements flow-down methodologies, tight project schedules and complex interfaces called for frequent end-to-end demonstrations to provide feedbackmore » during system development. The development process maintained the many benefits of plan-driven project execution with the rapid prototyping, integration, demonstration, and client feedback possible through Agile development methods. This paper also describes some of the tools and implementing mechanisms used to transition between and take advantage of each methodology, and presents lessons learned from the project management, system engineering, and developer’s perspectives.« less

Survey Definitions of Gout for Epidemiologic Studies: Comparison With Crystal Identification as the Gold Standard.

PubMed

Dalbeth, Nicola; Schumacher, H Ralph; Fransen, Jaap; Neogi, Tuhina; Jansen, Tim L; Brown, Melanie; Louthrenoo, Worawit; Vazquez-Mellado, Janitzia; Eliseev, Maxim; McCarthy, Geraldine; Stamp, Lisa K; Perez-Ruiz, Fernando; Sivera, Francisca; Ea, Hang-Korng; Gerritsen, Martijn; Scire, Carlo A; Cavagna, Lorenzo; Lin, Chingtsai; Chou, Yin-Yi; Tausche, Anne-Kathrin; da Rocha Castelar-Pinheiro, Geraldo; Janssen, Matthijs; Chen, Jiunn-Horng; Cimmino, Marco A; Uhlig, Till; Taylor, William J

2016-12-01

To identify the best-performing survey definition of gout from items commonly available in epidemiologic studies. Survey definitions of gout were identified from 34 epidemiologic studies contributing to the Global Urate Genetics Consortium (GUGC) genome-wide association study. Data from the Study for Updated Gout Classification Criteria (SUGAR) were randomly divided into development and test data sets. A data-driven case definition was formed using logistic regression in the development data set. This definition, along with definitions used in GUGC studies and the 2015 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) gout classification criteria were applied to the test data set, using monosodium urate crystal identification as the gold standard. For all tested GUGC definitions, the simple definition of "self-report of gout or urate-lowering therapy use" had the best test performance characteristics (sensitivity 82%, specificity 72%). The simple definition had similar performance to a SUGAR data-driven case definition with 5 weighted items: self-report, self-report of doctor diagnosis, colchicine use, urate-lowering therapy use, and hyperuricemia (sensitivity 87%, specificity 70%). Both of these definitions performed better than the 1977 American Rheumatism Association survey criteria (sensitivity 82%, specificity 67%). Of all tested definitions, the 2015 ACR/EULAR criteria had the best performance (sensitivity 92%, specificity 89%). A simple definition of "self-report of gout or urate-lowering therapy use" has the best test performance characteristics of existing definitions that use routinely available data. A more complex combination of features is more sensitive, but still lacks good specificity. If a more accurate case definition is required for a particular study, the 2015 ACR/EULAR gout classification criteria should be considered. © 2016, American College of Rheumatology.

Cost-Driven Design of a Large Scale X-Plane

NASA Technical Reports Server (NTRS)

Welstead, Jason R.; Frederic, Peter C.; Frederick, Michael A.; Jacobson, Steven R.; Berton, Jeffrey J.

2017-01-01

A conceptual design process focused on the development of a low-cost, large scale X-plane was developed as part of an internal research and development effort. One of the concepts considered for this process was the double-bubble configuration recently developed as an advanced single-aisle class commercial transport similar in size to a Boeing 737-800 or Airbus A320. The study objective was to reduce the contractor cost from contract award to first test flight to less than $100 million, and having the first flight within three years of contract award. Methods and strategies for reduced cost are discussed.

Operation and development status of the J-PARC ion source

NASA Astrophysics Data System (ADS)

Yamazaki, S.; Ikegami, K.; Ohkoshi, K.; Ueno, A.; Koizumi, I.; Takagi, A.; Oguri, H.

2014-02-01

A cesium-free H- ion source driven with a LaB6 filament is being operated at the Japan Proton Accelerator Research Complex (J-PARC) without any serious trouble since the restoration from the March 2011 earthquake. The H- ion current from the ion source is routinely restricted approximately 19 mA for the lifetime of the filament. In order to increase the beam power at the linac beam operation (January to February 2013), the beam current from the ion source was increased to 22 mA. At this operation, the lifetime of the filament was estimated by the reduction in the filament current. According to the steep reduction in the filament current, the break of the filament was predicted. Although the filament has broken after approximately 10 h from the steep current reduction, the beam operation was restarted approximately 8 h later by the preparation for the exchange of new filament. At the study time for the 3 GeV rapid cycling synchrotron (April 2013), the ion source was operated at approximately 30 mA for 8 days. As a part of the beam current upgrade plan for the J-PARC, the front end test stand consisting of the ion source and the radio frequency quadrupole is under preparation. The RF-driven H- ion source developed for the J-PARC 2nd stage requirements will be tested at this test stand.

Built To Last: Using Iterative Development Models for Sustainable Scientific Software Development

NASA Astrophysics Data System (ADS)

Jasiak, M. E.; Truslove, I.; Savoie, M.

2013-12-01

In scientific research, software development exists fundamentally for the results they create. The core research must take focus. It seems natural to researchers, driven by grant deadlines, that every dollar invested in software development should be used to push the boundaries of problem solving. This system of values is frequently misaligned with those of the software being created in a sustainable fashion; short-term optimizations create longer-term sustainability issues. The National Snow and Ice Data Center (NSIDC) has taken bold cultural steps in using agile and lean development and management methodologies to help its researchers meet critical deadlines, while building in the necessary support structure for the code to live far beyond its original milestones. Agile and lean software development and methodologies including Scrum, Kanban, Continuous Delivery and Test-Driven Development have seen widespread adoption within NSIDC. This focus on development methods is combined with an emphasis on explaining to researchers why these methods produce more desirable results for everyone, as well as promoting developers interacting with researchers. This presentation will describe NSIDC's current scientific software development model, how this addresses the short-term versus sustainability dichotomy, the lessons learned and successes realized by transitioning to this agile and lean-influenced model, and the current challenges faced by the organization.

J-2X Upper Stage Engine: Hardware and Testing 2009

NASA Technical Reports Server (NTRS)

Buzzell, James C.

2009-01-01

Mission: Common upper stage engine for Ares I and Ares V. Challenge: Use proven technology from Saturn X-33, RS-68 to develop the highest Isp GG cycle engine in history for 2 missions in record time . Key Features: LOX/LH2 GG cycle, series turbines (2), HIP-bonded MCC, pneumatic ball-sector valves, on-board engine controller, tube-wall regen nozzle/large passively-cooled nozzle extension, TEG boost/cooling . Development Philosophy: proven hardware, aggressive schedule, early risk reduction, requirements-driven.

Model Driven Engineering

NASA Astrophysics Data System (ADS)

Gaševic, Dragan; Djuric, Dragan; Devedžic, Vladan

A relevant initiative from the software engineering community called Model Driven Engineering (MDE) is being developed in parallel with the Semantic Web (Mellor et al. 2003a). The MDE approach to software development suggests that one should first develop a model of the system under study, which is then transformed into the real thing (i.e., an executable software entity). The most important research initiative in this area is the Model Driven Architecture (MDA), which is Model Driven Architecture being developed under the umbrella of the Object Management Group (OMG). This chapter describes the basic concepts of this software engineering effort.

Convenience experimentation.

PubMed

Krohs, Ulrich

2012-03-01

Systems biology aims at explaining life processes by means of detailed models of molecular networks, mainly on the whole-cell scale. The whole cell perspective distinguishes the new field of systems biology from earlier approaches within molecular cell biology. The shift was made possible by the high throughput methods that were developed for gathering 'omic' (genomic, proteomic, etc.) data. These new techniques are made commercially available as semi-automatic analytic equipment, ready-made analytic kits and probe arrays. There is a whole industry of supplies for what may be called convenience experimentation. My paper inquires some epistemic consequences of strong reliance on convenience experimentation in systems biology. In times when experimentation was automated to a lesser degree, modeling and in part even experimentation could be understood fairly well as either being driven by hypotheses, and thus proceed by the testing of hypothesis, or as being performed in an exploratory mode, intended to sharpen concepts or initially vague phenomena. In systems biology, the situation is dramatically different. Data collection became so easy (though not cheap) that experimentation is, to a high degree, driven by convenience equipment, and model building is driven by the vast amount of data that is produced by convenience experimentation. This results in a shift in the mode of science. The paper shows that convenience driven science is not primarily hypothesis-testing, nor is it in an exploratory mode. It rather proceeds in a gathering mode. This shift demands another shift in the mode of evaluation, which now becomes an exploratory endeavor, in response to the superabundance of gathered data. Copyright © 2011 Elsevier Ltd. All rights reserved.

False Discovery Control in Large-Scale Spatial Multiple Testing

PubMed Central

Sun, Wenguang; Reich, Brian J.; Cai, T. Tony; Guindani, Michele; Schwartzman, Armin

2014-01-01

Summary This article develops a unified theoretical and computational framework for false discovery control in multiple testing of spatial signals. We consider both point-wise and cluster-wise spatial analyses, and derive oracle procedures which optimally control the false discovery rate, false discovery exceedance and false cluster rate, respectively. A data-driven finite approximation strategy is developed to mimic the oracle procedures on a continuous spatial domain. Our multiple testing procedures are asymptotically valid and can be effectively implemented using Bayesian computational algorithms for analysis of large spatial data sets. Numerical results show that the proposed procedures lead to more accurate error control and better power performance than conventional methods. We demonstrate our methods for analyzing the time trends in tropospheric ozone in eastern US. PMID:25642138

An Item-Driven Adaptive Design for Calibrating Pretest Items. Research Report. ETS RR-14-38

ERIC Educational Resources Information Center

Ali, Usama S.; Chang, Hua-Hua

2014-01-01

Adaptive testing is advantageous in that it provides more efficient ability estimates with fewer items than linear testing does. Item-driven adaptive pretesting may also offer similar advantages, and verification of such a hypothesis about item calibration was the main objective of this study. A suitability index (SI) was introduced to adaptively…

Construct-Driven SJTs: Toward an Agenda for Future Research

ERIC Educational Resources Information Center

Lievens, Filip

2017-01-01

A common theme running through recent research on Situational Judgment Tests (SJTs) and this special issue is the aim to improve the measurement of constructs via SJTs. Construct-driven SJTs differ from traditional SJTs in that they present a trait activating situation to test-takers and a more unidimensional set of response options that depict…

Description of the Prometheus Program Alternator/Thruster Integration Laboratory (ATIL)

NASA Technical Reports Server (NTRS)

Baez, Anastacio N.; Birchenough, Arthur G.; Lebron-Velilla, Ramon C.; Gonzalez, Marcelo C.

2005-01-01

The Project Prometheus Alternator Electric Thruster Integration Laboratory's (ATIL) primary two objectives are to obtain test data to influence the power conversion and electric propulsion systems design, and to assist in developing the primary power quality specifications prior to system Preliminary Design Review (PDR). ATIL is being developed in stages or configurations of increasing fidelity and complexity in order to support the various phases of the Prometheus program. ATIL provides a timely insight of the electrical interactions between a representative Permanent Magnet Generator, its associated control schemes, realistic electric system loads, and an operating electric propulsion thruster. The ATIL main elements are an electrically driven 100 kWe Alternator Test Unit (ATU), an alternator controller using parasitic loads, and a thruster Power Processing Unit (PPU) breadboard. This paper describes the ATIL components, its development approach, preliminary integration test results, and current status.

Laser detonator development for test-firing applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Munger, A. C.; Thomas, K. A.; Kennedy, J. E.

2004-01-01

Los Alamos National Laboratory has historically fielded two types of electro-explosive detonators. The exploding-bridgewire detonator (EBW) has an exploding wire as the initiating element, a low-density transfer charge and a high-density output pellet. The slapper detonator, or exploding-foil initiator (EFI), utilizes an exploding foil to drive a flying plate element into a high-density output pellet. The last twenty years has seen various research and development activities from many laboratories and manufacturing facilities around the world to develop laser-driven analogs of these devices, but to our knowledge none of those is in general use. Los Alamos is currently committed to designmore » and manufacture a laser analog to the long-standing, generic, general-purpose SE-1 EBW detonator, which is intended to provide increased safety in large-scale test-firing operations. This paper will discuss the major design parameters of this laser detonator and present some preliminary testing results.« less

Development of a High Accuracy Angular Measurement System for Langley Research Center Hypersonic Wind Tunnel Facilities

NASA Technical Reports Server (NTRS)

Newman, Brett; Yu, Si-bok; Rhew, Ray D. (Technical Monitor)

2003-01-01

Modern experimental and test activities demand innovative and adaptable procedures to maximize data content and quality while working within severely constrained budgetary and facility resource environments. This report describes development of a high accuracy angular measurement capability for NASA Langley Research Center hypersonic wind tunnel facilities to overcome these deficiencies. Specifically, utilization of micro-electro-mechanical sensors including accelerometers and gyros, coupled with software driven data acquisition hardware, integrated within a prototype measurement system, is considered. Development methodology addresses basic design requirements formulated from wind tunnel facility constraints and current operating procedures, as well as engineering and scientific test objectives. Description of the analytical framework governing relationships between time dependent multi-axis acceleration and angular rate sensor data and the desired three dimensional Eulerian angular state of the test model is given. Calibration procedures for identifying and estimating critical parameters in the sensor hardware is also addressed.

Scale Model Test and Transient Analysis of Steam Injector Driven Passive Core Injection System for Innovative-Simplified Nuclear Power Plant

NASA Astrophysics Data System (ADS)

Ohmori, Shuichi; Narabayashi, Tadashi; Mori, Michitsugu

A steam injector (SI) is a simple, compact and passive pump and also acts as a high-performance direct-contact compact heater. This provides SI with capability to serve also as a direct-contact feed-water heater that heats up feed-water by using extracted steam from turbine. Our technology development aims to significantly simplify equipment and reduce physical quantities by applying "high-efficiency SI", which are applicable to a wide range of operation regimes beyond the performance and applicable range of existing SIs and enables unprecedented multistage and parallel operation, to the low-pressure feed-water heaters and emergency core cooling system of nuclear power plants, as well as achieve high inherent safety to prevent severe accidents by keeping the core covered with water (a severe accident-free concept). This paper describes the results of the scale model test, and the transient analysis of SI-driven passive core injection system (PCIS).

Experimental Study and Optimization of Thermoelectricity-Driven Autonomous Sensors for the Chimney of a Biomass Power Plant

NASA Astrophysics Data System (ADS)

Rodríguez, A.; Astrain, D.; Martínez, A.; Aranguren, P.

2014-06-01

In the work discussed in this paper a thermoelectric generator was developed to harness waste heat from the exhaust gas of a boiler in a biomass power plant and thus generate electric power to operate a flowmeter installed in the chimney, to make it autonomous. The main objective was to conduct an experimental study to optimize a previous design obtained after computational work based on a simulation model for thermoelectric generators. First, several places inside and outside the chimney were considered as sites for the thermoelectricity-driven autonomous sensor. Second, the thermoelectric generator was built and tested to assess the effect of the cold-side heat exchanger on the electric power, power consumption by the flowmeter, and transmission frequency. These tests provided the best configuration for the heat exchanger, which met the transmission requirements for different working conditions. The final design is able to transmit every second and requires neither batteries nor electric wires. It is a promising application in the field of thermoelectric generation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Riensche, Roderick M.; Paulson, Patrick R.; Danielson, Gary R.

We describe a methodology and architecture to support the development of games in a predictive analytics context. These games serve as part of an overall family of systems designed to gather input knowledge, calculate results of complex predictive technical and social models, and explore those results in an engaging fashion. The games provide an environment shaped and driven in part by the outputs of the models, allowing users to exert influence over a limited set of parameters, and displaying the results when those actions cause changes in the underlying model. We have crafted a prototype system in which we aremore » implementing test versions of games driven by models in such a fashion, using a flexible architecture to allow for future continuation and expansion of this work.« less

A more rational, theory-driven approach to analysing the factor structure of the Edinburgh Postnatal Depression Scale.

PubMed

Kozinszky, Zoltan; Töreki, Annamária; Hompoth, Emőke A; Dudas, Robert B; Németh, Gábor

2017-04-01

We endeavoured to analyze the factor structure of the Edinburgh Postnatal Depression Scale (EPDS) during a screening programme in Hungary, using exploratory (EFA) and confirmatory factor analysis (CFA), testing both previously published models and newly developed theory-driven ones, after a critical analysis of the literature. Between April 2011 and January 2015, a sample of 2967 pregnant women (between 12th and 30th weeks of gestation) and 714 women 6 weeks after delivery completed the Hungarian version of the EPDS in South-East Hungary. EFAs suggested unidimensionality in both samples. 33 out of 42 previously published models showed good and 6 acceptable fit with our antepartum data in CFAs, whilst 10 of them showed good and 28 acceptable fit in our postpartum sample. Using multiple fit indices, our theory-driven anhedonia (items 1,2) - anxiety (items 4,5) - low mood (items 8,9) model provided the best fit in the antepartum sample. In the postpartum sample, our theory-driven models were again among the best performing models, including an anhedonia and an anxiety factor together with either a low mood or a suicidal risk factor (items 3,6,10). The EPDS showed moderate within- and between-culture invariability, although this would also need to be re-examined with a theory-driven approach. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

Balancing Plan-Driven and Agile Methods in Software Engineering Project Courses

NASA Astrophysics Data System (ADS)

Boehm, Barry; Port, Dan; Winsor Brown, A.

2002-09-01

For the past 6 years, we have been teaching a two-semester software engineering project course. The students organize into 5-person teams and develop largely web-based electronic services projects for real USC campus clients. We have been using and evolving a method called Model- Based (System) Architecting and Software Engineering (MBASE) for use in both the course and in industrial applications. The MBASE Guidelines include a lot of documents. We teach risk-driven documentation: if it is risky to document something, and not risky to leave it out (e.g., GUI screen placements), leave it out. Even so, students tend to associate more documentation with higher grades, although our grading eventually discourages this. We are always on the lookout for ways to have students learn best practices without having to produce excessive documentation. Thus, we were very interested in analyzing the various emerging agile methods. We found that agile methods and milestone plan-driven methods are part of a “how much planning is enough?” spectrum. Both agile and plan-driven methods have home grounds of project characteristics where they clearly work best, and where the other will have difficulties. Hybrid agile/plan-driven approaches are feasible, and necessary for projects having a mix of agile and plan-driven home ground characteristics. Information technology trends are going more toward the agile methods' home ground characteristics of emergent requirements and rapid change, although there is a concurrent increase in concern with dependability. As a result, we are currently experimenting with risk-driven combinations of MBASE and agile methods, such as integrating requirements, test plans, peer reviews, and pair programming into “agile quality management.”

Development of an integrated set of research facilities for the support of research flight test

NASA Technical Reports Server (NTRS)

Moore, Archie L.; Harney, Constance D.

1988-01-01

The Ames-Dryden Flight Research Facility (DFRF) serves as the site for high-risk flight research on many one-of-a-kind test vehicles like the X-29A advanced technology demonstrator, F-16 advanced fighter technology integration (AFTI), AFTI F-111 mission adaptive wing, and F-18 high-alpha research vehicle (HARV). Ames-Dryden is on a section of the historic Muroc Range. The facility is oriented toward the testing of high-performance aircraft, as shown by its part in the development of the X-series aircraft. Given the cost of research flight tests and the complexity of today's systems-driven aircraft, an integrated set of ground support experimental facilities is a necessity. In support of the research flight test of highly advanced test beds, the DFRF is developing a network of facilities to expedite the acquisition and distribution of flight research data to the researcher. The network consists of an array of experimental ground-based facilities and systems as nodes and the necessary telecommunications paths to pass research data and information between these facilities. This paper presents the status of the current network, an overview of current developments, and a prospectus on future major enhancements.

Automotive Stirling Engine Development Project

NASA Technical Reports Server (NTRS)

Ernst, William D.; Shaltens, Richard K.

1997-01-01

The development and verification of automotive Stirling engine (ASE) component and system technology is described as it evolved through two experimental engine designs: the Mod 1 and the Mod 2. Engine operation and performance and endurance test results for the Mod 1 are summarized. Mod 2 engine and component development progress is traced from the original design through hardware development, laboratory test, and vehicle installation. More than 21,000 hr of testing were accomplished, including 4800 hr with vehicles that were driven more dm 59,000 miles. Mod 2 engine dynamometer tests demonstrated that the engine system configuration had accomplished its performance goals for power (60 kW) and efficiency (38.5%) to within a few percent. Tests with the Mod 2 engine installed in a delivery van demonstrated combined metro-highway fuel economy improvements consistent with engine performance goals and the potential for low emission levels. A modified version of the Mod 2 has been identified as a manufacturable design for an ASE. As part of the ASE project, the Industry Test and Evaluation Program (ITEP), NASA Technology Utilization (TU) project, and the industry-funded Stirling Natural Gas Engine program were undertaken to transfer ASE technology to end users. The results of these technology transfer efforts are also summarized.

A rule-based system for real-time analysis of control systems

NASA Astrophysics Data System (ADS)

Larson, Richard R.; Millard, D. Edward

1992-10-01

An approach to automate the real-time analysis of flight critical health monitoring and system status is being developed and evaluated at the NASA Dryden Flight Research Facility. A software package was developed in-house and installed as part of the extended aircraft interrogation and display system. This design features a knowledge-base structure in the form of rules to formulate interpretation and decision logic of real-time data. This technique has been applied for ground verification and validation testing and flight testing monitoring where quick, real-time, safety-of-flight decisions can be very critical. In many cases post processing and manual analysis of flight system data are not required. The processing is described of real-time data for analysis along with the output format which features a message stack display. The development, construction, and testing of the rule-driven knowledge base, along with an application using the X-31A flight test program, are presented.

A rule-based system for real-time analysis of control systems

NASA Technical Reports Server (NTRS)

Larson, Richard R.; Millard, D. Edward

1992-01-01

An approach to automate the real-time analysis of flight critical health monitoring and system status is being developed and evaluated at the NASA Dryden Flight Research Facility. A software package was developed in-house and installed as part of the extended aircraft interrogation and display system. This design features a knowledge-base structure in the form of rules to formulate interpretation and decision logic of real-time data. This technique has been applied for ground verification and validation testing and flight testing monitoring where quick, real-time, safety-of-flight decisions can be very critical. In many cases post processing and manual analysis of flight system data are not required. The processing is described of real-time data for analysis along with the output format which features a message stack display. The development, construction, and testing of the rule-driven knowledge base, along with an application using the X-31A flight test program, are presented.

Effect of heliox- and air-driven nebulized bronchodilator therapy on lung function in patients with asthma.

PubMed

El-Khatib, Mohamad F; Jamaleddine, Ghassan; Kanj, Nadim; Zeineddine, Salah; Chami, Hassan; Bou-Akl, Imad; Husari, Ahmad; Alawieh, Marwan; Bou-Khalil, Pierre

2014-06-01

This study compares the effect of heliox-driven to that of air-driven bronchodilator therapy on the pulmonary function test (PFT) in patients with different levels of asthma severity. One-hundred thirty-two participants were included in the study. Participants underwent spirometry twice with bronchodilator testing on two consecutive days. Air-driven nebulization was used one day and heliox-driven nebulization the other day in random order crossover design. After a baseline PFT, each participant received 2.5 mg of albuterol sulfate nebulized with the randomized driving gas. Post bronchodilator PFT was repeated after 30 min. The next day, the exact same protocol was repeated, except that the other driving gas was used to nebulize the drug. Participants were subgrouped and analyzed according to their baseline FEV(1) on day 1: Group I, FEV(1) ≥80 %; Group II, 80 % > FEV(1) > 50 %; Group III, FEV(1) ≤50 %. The proportion of participants with greater than 12 % and 200-mL increases from their baseline FEV(1) and the changes from baseline in PFT variables were compared between heliox-driven versus air-driven bronchodilation therapy. The proportion of participants with >12 % and 200-mL increases from their baseline FEV(1) with air- or heliox-driven bronchodilation was not different with respect to the proportion of participants with baseline FEV(1) ≥80 % (20 vs. 18 %, respectively) and 80 % > FEV(1) > 50 % (36 vs. 43 %, respectively), but it was significantly greater with heliox-driven bronchodilation in participants with FEV(1) ≤50 % (43 vs. 73 %, respectively; p = 0.01). Changes from baseline FVC, FEV(1), FEV(1)/FVC, FEF(25-75) %, FEF(max), FEF(25) %, FEF(50) %, and FEF(75) % were significantly larger with heliox-driven versus air-driven bronchodilation in participants with baseline FEV(1) ≤50 %. Improvements in PFT variables are more frequent and profound with heliox-driven compared to air-driven bronchodilator therapy only in asthmatic patients with baseline FEV(1) ≤50 %.

Using "Saccharomyces cerevisiae" to Test the Mutagenicity of Household Compounds: An Open Ended Hypothesis-Driven Teaching Lab

ERIC Educational Resources Information Center

Marshall, Pamela A.

2007-01-01

In our Fundamentals of Genetics lab, students perform a wide variety of labs to reinforce and extend the topics covered in lecture. I developed an active-learning lab to augment the lecture topic of mutagenesis. In this lab exercise, students determine if a compound they bring from home is a mutagen. Students are required to read extensive…

Games for Enhancing Sustainability of Year 7 Maths Classes in Indonesia: Theory-Driven Development, Testing and Analyses of Lessons, and of Students' Outcomes

ERIC Educational Resources Information Center

Kaune, Christa; Nowinska, Edyta; Paetau, Annika; Griep, Mathilde

2013-01-01

The results of international comparative studies have shown that relationships exist between metacognition and cognitive activation and learning success. Since 2007 we have been carrying out projects in Indonesia to improve cognitive and metacognitive activities of pupils of year 7 and their teachers. These activities are to contribute to the…

Control methodologies for large space structures

NASA Technical Reports Server (NTRS)

Mcree, G. J.; Altonji, E.

1984-01-01

The objectives of this research were to develop techniques of controlling a dc-motor driven flywheel which would apply torque to the structure to which it was mounted. The motor control system was to be implemented using a microprocessor based controller. The purpose of the torque applied by this system was to dampen oscillations of the structure to which it was mounted. Before the work was terminated due to the unavailability of equipment, a system was developed and partially tested which would provide tight control of the flywheel velocity when it received a velocity command in the form of a voltage. The procedure followed in this development was to first model the motor and flywheel system on an analog computer. Prior to the time the microprocessor development system was available, an analog control loop was replaced by the microprocessor and the system was partially tested.

Considerations for a business model for the effective integration of novel biomarkers into drug development.

PubMed

Frueh, Felix W

2008-11-01

It is 10 years since the introduction of trastuzumab into the US market, and we are still waiting for a validation of the business case for biomarker-driven drug development. While many reasons for the lack of duplication of this model may exist, the need for accelerated innovation in drug development paired with the opportunity of integrating biomarker-driven research into drug development programs may lead to new and creative ways of fostering the cooperation between drug developers and test manufacturers. The rapid increase in knowledge about biomarkers and our understanding of disease and disease mechanisms open unprecedented prospects to make not only better, more informed decisions regarding patient care, but also strategic decisions during drug development. This requires that a biomarker strategy becomes an integral part of (early) drug development and that new, innovative paths are tried towards a model that combines the scientific approach with an economically feasible implementation strategy. Collaborative research, the use of new communication tools, the exploration of alternative ways to position a product in the market, and other considerations are part of such a strategy. This perspective article illustrates the current landscape and takes a look at some of these new ways for more effectively integrating biomarkers into drug development.

The sciences and applications of the Electron LINAC-driven neutron source in Argentina

NASA Astrophysics Data System (ADS)

Granada, J. R.; Mayer, R. E.; Dawidowski, J.; Santisteban, J. R.; Cantargi, F.; Blostein, J. J.; Rodríguez Palomino, L. A.; Tartaglione, A.

2016-06-01

The Neutron Physics group at Centro Atómico Bariloche (CNEA, Argentina) has evolved for more than forty five years around a small 25MeV linear electron accelerator. It constitutes our compact accelerator-driven neutron source (CANS), which is dedicated to the use and development of neutronic methods to tackle problems of basic sciences and technological applications. Its historical first commitment has been the determination of the total cross sections of materials as a function of neutron energy by means of transmission experiments for thermal and sub-thermal neutrons. This also allowed testing theoretical models for the generation of scattering kernels and cross sections. Through the years, our interests moved from classic pulsed neutron diffraction, which included the development of high-precision methods for the determination of very low hydrogen content in metals, towards deep inelastic neutron scattering (DINS), a powerful tool for the determination of atomic momentum distribution in condensed matter. More recently non-intrusive techniques aimed at the scanning of large cargo containers have started to be developed with our CANS, testing the capacity and limitations to detect special nuclear material and dangerous substances. Also, the ever-present "bremsstrahlung" radiation has been recognized and tested as a useful complement to instrumental neutron activation, as it permits to detect other nuclear species through high-energy photon activation. The facility is also used for graduate and undergraduate students' experimental work within the frame of Instituto Balseiro Physics and Nuclear Engineering courses of study, and also MSc and PhD theses work.

An Integrated Data-Driven Strategy for Safe-by-Design Nanoparticles: The FP7 MODERN Project.

PubMed

Brehm, Martin; Kafka, Alexander; Bamler, Markus; Kühne, Ralph; Schüürmann, Gerrit; Sikk, Lauri; Burk, Jaanus; Burk, Peeter; Tamm, Tarmo; Tämm, Kaido; Pokhrel, Suman; Mädler, Lutz; Kahru, Anne; Aruoja, Villem; Sihtmäe, Mariliis; Scott-Fordsmand, Janeck; Sorensen, Peter B; Escorihuela, Laura; Roca, Carlos P; Fernández, Alberto; Giralt, Francesc; Rallo, Robert

2017-01-01

The development and implementation of safe-by-design strategies is key for the safe development of future generations of nanotechnology enabled products. The safety testing of the huge variety of nanomaterials that can be synthetized is unfeasible due to time and cost constraints. Computational modeling facilitates the implementation of alternative testing strategies in a time and cost effective way. The development of predictive nanotoxicology models requires the use of high quality experimental data on the structure, physicochemical properties and bioactivity of nanomaterials. The FP7 Project MODERN has developed and evaluated the main components of a computational framework for the evaluation of the environmental and health impacts of nanoparticles. This chapter describes each of the elements of the framework including aspects related to data generation, management and integration; development of nanodescriptors; establishment of nanostructure-activity relationships; identification of nanoparticle categories; hazard ranking and risk assessment.

Biomechanical comparison of a novel engine-driven ridge spreader and conventional ridge splitting techniques.

PubMed

Jung, Gyu-Un; Kim, Jun Hwan; Lim, Nam Hun; Yoon, Gil Ho; Han, Ji-Young

2017-06-01

Ridge splitting techniques are used for horizontal ridge augmentation in implant dentistry. Recently, a novel engine-driven ridge splitting technique was introduced. This study compared the mechanical forces produced by conventional and engine-driven ridge splitting techniques in porcine mandibles. In 33 pigs, mandibular premolar areas were selected for the ridge splitting procedures, designed as a randomized split-mouth study. The conventional group underwent a chisel-and-mallet procedure (control group, n = 20), and percussive impulse (Newton second, Ns) was measured using a sensor attached to the mallet. In the engine-driven ridge spreader group (test group, n = 23), a load cell was used to measure torque values (Newton centimeter, Ncm). Horizontal acceleration generated during procedures (control group, n = 10 and test group, n = 10) was compared between the groups. After ridge splitting, the alveolar crest width was significantly increased both in the control (1.23 ± 0.45 mm) and test (0.98 ± 0.41 mm) groups with no significant differences between the groups. The average impulse of the control group was 4.74 ± 1.05 Ns. Torque generated by rotation in the test group was 9.07 ± 2.15 Ncm. Horizontal acceleration was significantly less in the test group (0.82 ± 1.05 g) than the control group (64.07 ± 42.62 g) (P < 0.001). Narrow edentulous ridges can be expanded by novel engine-driven ridge spreaders. Within the limits of this study, the results suggested that an engine-driven ridge splitting technique may be less traumatic and less invasive than a conventional ridge splitting technique. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Integrated Human-in-the-Loop Ground Testing - Value, History, and the Future

NASA Technical Reports Server (NTRS)

Henninger, Donald L.

2016-01-01

Systems for very long-duration human missions to Mars will be designed to operate reliably for many years and many of these systems will never be returned to Earth. The need for high reliability is driven by the requirement for safe functioning of remote, long-duration crewed systems and also by unsympathetic abort scenarios. Abort from a Mars mission could be as long as 450 days to return to Earth. The key to developing a human-in-the-loop architecture is a development process that allows for a logical sequence of validating successful development in a stepwise manner, with assessment of key performance parameters (KPPs) at each step; especially important are KPPs for technologies evaluated in a full systems context with human crews on Earth and on space platforms such as the ISS. This presentation will explore the implications of such an approach to technology development and validation including the roles of ground and space-based testing necessary to develop a highly reliable system for long duration human exploration missions. Historical development and systems testing from Mercury to the International Space Station (ISS) to ground testing will be reviewed. Current work as well as recommendations for future work will be described.

Natural Gas Engine-Driven Heat Pump Demonstration at DoD Installations: Performance and Reliability Summary

DTIC Science & Technology

2009-06-09

ER D C/ CE R L TR -0 9 -1 0 Natural Gas Engine-Driven Heat Pump Demonstration at DoD Installations Performance and Reliability Summary...L ab or at or y Approved for public release; distribution is unlimited. ERDC/CERL TR-09-10 June 2009 Natural Gas Engine-Driven Heat Pump ...CERL TR-09-10 ii Abstract: Results of field testing natural gas engine-driven heat pumps (GHP) at six southwestern U.S. Department of Defense (DoD

Implementing NASA's Capability-Driven Approach: Insight into NASA's Processes for Maturing Exploration Systems

NASA Technical Reports Server (NTRS)

Williams-Byrd, Julie; Arney, Dale; Rodgers, Erica; Antol, Jeff; Simon, Matthew; Hay, Jason; Larman, Kevin

2015-01-01

NASA is engaged in transforming human spaceflight. The Agency is shifting from an exploration-based program with human activities focused on low Earth orbit (LEO) and targeted robotic missions in deep space to a more sustainable and integrated pioneering approach. Through pioneering, NASA seeks to address national goals to develop the capacity for people to work, learn, operate, live, and thrive safely beyond the Earth for extended periods of time. However, pioneering space involves more than the daunting technical challenges of transportation, maintaining health, and enabling crew productivity for long durations in remote, hostile, and alien environments. This shift also requires a change in operating processes for NASA. The Agency can no longer afford to engineer systems for specific missions and destinations and instead must focus on common capabilities that enable a range of destinations and missions. NASA has codified a capability driven approach, which provides flexible guidance for the development and maturation of common capabilities necessary for human pioneers beyond LEO. This approach has been included in NASA policy and is captured in the Agency's strategic goals. It is currently being implemented across NASA's centers and programs. Throughout 2014, NASA engaged in an Agency-wide process to define and refine exploration-related capabilities and associated gaps, focusing only on those that are critical for human exploration beyond LEO. NASA identified 12 common capabilities ranging from Environmental Control and Life Support Systems to Robotics, and established Agency-wide teams or working groups comprised of subject matter experts that are responsible for the maturation of these exploration capabilities. These teams, called the System Maturation Teams (SMTs) help formulate, guide and resolve performance gaps associated with the identified exploration capabilities. The SMTs are defining performance parameters and goals for each of the 12 capabilities, developing maturation plans and roadmaps for the identified performance gaps, specifying the interfaces between the various capabilities, and ensuring that the capabilities mature and integrate to enable future pioneering missions. By managing system development through the SMTs instead of traditional NASA programs and projects, the Agency is shifting from mission-driven development to a more flexible, capability-driven development. The process NASA uses to establish, integrate, prioritize, and manage the SMTs and associated capabilities is iterative. NASA relies on the Human Exploration and Operation Mission Directorate's SMT Integration Team within Advanced Exploration Systems to coordinate and facilitate the SMT process. The SMT Integration team conducts regular reviews and coordination meetings among the SMTs and has developed a number of tools to help the Agency implement capability driven processes. The SMT Integration team is uniquely positioned to help the Agency coordinate the SMTs and other processes that are making the capability-driven approach a reality. This paper will introduce the SMTs and the 12 key capabilities they represent. The role of the SMTs will be discussed with respect to Agency-wide processes to shift from mission-focused exploration to a capability-driven pioneering approach. Specific examples will be given to highlight systems development and testing within the SMTs. These examples will also show how NASA is using current investments in the International Space Station and future investments to develop and demonstrate capabilities. The paper will conclude by describing next steps and a process for soliciting feedback from the space exploration community to refine NASA's process for developing common exploration capabilities.

Community-driven demand creation for the use of routine viral load testing: a model to scale up routine viral load testing.

PubMed

Killingo, Bactrin M; Taro, Trisa B; Mosime, Wame N

2017-11-01

HIV treatment outcomes are dependent on the use of viral load measurement. Despite global and national guidelines recommending the use of routine viral load testing, these policies alone have not translated into widespread implementation or sufficiently increased access for people living with HIV (PLHIV). Civil society and communities of PLHIV recognize the need to close this gap and to enable the scale up of routine viral load testing. The International Treatment Preparedness Coalition (ITPC) developed an approach to community-led demand creation for the use of routine viral load testing. Using this Community Demand Creation Model, implementers follow a step-wise process to capacitate and empower communities to address their most pressing needs. This includes utlizing a specific toolkit that includes conducting a baseline assessment, developing a treatment education toolkit, organizing mobilization workshops for knowledge building, provision of small grants to support advocacy work and conducting benchmark evaluations. The Community Demand Creation Model to increase demand for routine viral load testing services by PLHIV has been delivered in diverse contexts including in the sub-Saharan African, Asian, Latin American and the Caribbean regions. Between December 2015 and December 2016, ITPC trained more than 240 PLHIV activists, and disbursed US$90,000 to network partners in support of their national advocacy work. The latter efforts informed a regional, community-driven campaign calling for domestic investment in the expeditious implementation of national viral load testing guidelines. HIV treatment education and community mobilization are critical components of demand creation for access to optimal HIV treatment, especially for the use of routine viral load testing. ITPC's Community Demand Creation Model offers a novel approach to achieving this goal. © 2017 The Authors. Journal of the International AIDS Society published by John Wiley & sons Ltd on behalf of the International AIDS Society.

Evaluating laser-driven Bremsstrahlung radiation sources for imaging and analysis of nuclear waste packages.

PubMed

Jones, Christopher P; Brenner, Ceri M; Stitt, Camilla A; Armstrong, Chris; Rusby, Dean R; Mirfayzi, Seyed R; Wilson, Lucy A; Alejo, Aarón; Ahmed, Hamad; Allott, Ric; Butler, Nicholas M H; Clarke, Robert J; Haddock, David; Hernandez-Gomez, Cristina; Higginson, Adam; Murphy, Christopher; Notley, Margaret; Paraskevoulakos, Charilaos; Jowsey, John; McKenna, Paul; Neely, David; Kar, Satya; Scott, Thomas B

2016-11-15

A small scale sample nuclear waste package, consisting of a 28mm diameter uranium penny encased in grout, was imaged by absorption contrast radiography using a single pulse exposure from an X-ray source driven by a high-power laser. The Vulcan laser was used to deliver a focused pulse of photons to a tantalum foil, in order to generate a bright burst of highly penetrating X-rays (with energy >500keV), with a source size of <0.5mm. BAS-TR and BAS-SR image plates were used for image capture, alongside a newly developed Thalium doped Caesium Iodide scintillator-based detector coupled to CCD chips. The uranium penny was clearly resolved to sub-mm accuracy over a 30cm(2) scan area from a single shot acquisition. In addition, neutron generation was demonstrated in situ with the X-ray beam, with a single shot, thus demonstrating the potential for multi-modal criticality testing of waste materials. This feasibility study successfully demonstrated non-destructive radiography of encapsulated, high density, nuclear material. With recent developments of high-power laser systems, to 10Hz operation, a laser-driven multi-modal beamline for waste monitoring applications is envisioned. Copyright © 2016. Published by Elsevier B.V.

Time of Flight based diagnostics for high energy laser driven ion beams

NASA Astrophysics Data System (ADS)

Scuderi, V.; Milluzzo, G.; Alejo, A.; Amico, A. G.; Booth, N.; Cirrone, G. A. P.; Doria, D.; Green, J.; Kar, S.; Larosa, G.; Leanza, R.; Margarone, D.; McKenna, P.; Padda, H.; Petringa, G.; Pipek, J.; Romagnani, L.; Romano, F.; Schillaci, F.; Borghesi, M.; Cuttone, G.; Korn, G.

2017-03-01

Nowadays the innovative high power laser-based ion acceleration technique is one of the most interesting challenges in particle acceleration field, showing attractive characteristics for future multidisciplinary applications, including medical ones. Nevertheless, peculiarities of optically accelerated ion beams make mandatory the development of proper transport, selection and diagnostics devices in order to deliver stable and controlled ion beams for multidisciplinary applications. This is the main purpose of the ELIMAIA (ELI Multidisciplinary Applications of laser-Ion Acceleration) beamline that will be realized and installed within 2018 at the ELI-Beamlines research center in the Czech Republic, where laser driven high energy ions, up to 60 MeV/n, will be available for users. In particular, a crucial role will be played by the on-line diagnostics system, recently developed in collaboration with INFN-LNS (Italy), consisting of TOF detectors, placed along the beamline (at different detection distances) to provide online monitoring of key characteristics of delivered beams, such as energy, fluence and ion species. In this contribution an overview on the ELIMAIA available ion diagnostics will be briefly given along with the preliminary results obtained during a test performed with high energy laser-driven proton beams accelerated at the VULCAN PW-laser available at RAL facility (U.K.).

Evaluation in the Design of Complex Systems

ERIC Educational Resources Information Center

Ho, Li-An; Schwen, Thomas M.

2006-01-01

We identify literature that argues the process of creating knowledge-based system is often imbalanced. In most knowledge-based systems, development is often technology-driven instead of requirement-driven. Therefore, we argue designers must recognize that evaluation is a critical link in the application of requirement-driven development models…

Development of a Miniature, Two-Axis, Triple-Helmholtz-Driven Gimbal

NASA Technical Reports Server (NTRS)

Sharif, Boz; Joscelyn, Ed; Wilcox, Brian; Johnson, Michael R.

2000-01-01

This paper details the development of a Helmholtz-driven, 2-axis gimbal to position a flat mirror within 50 microradian (fine positioning) in a space environment. The gimbal is intended to travel on a deep space mission mounted on a miniature "rover" vehicle. The gimbal will perform both pointing and scanning functions. The goal for total mass of the gimbal was 25 grams. The primary challenge was to design and build a bearing system that would achieve the required accuracy in addition to supporting the relatively large mass of the mirror and the outer gimbal. The mechanism is subjected to 100-G loading without the aid of any additional caging mechanism. Additionally, it was desired to have the same level of accuracy during Earth-bound, 1-G testing. Due to the inherent lack of damping in a zero-G, vacuum environment; the ability of the gimbal to respond to very small amounts of input energy is paramount. Initial testing of the first prototype revealed exceedingly long damping times required even while exposed to the damping effects of air and 1-G friction. It is envisioned that fine positioning of the gimbal will be accomplished in very small steps to avoid large disturbances to the mirror. Various bearing designs, including materials, lubrication options and bearing geometry will be discussed. In addition various options for the Helmholtz coil design will be explored with specific test data given. Ground testing in the presence of 1-G was compounded by the local magnetic fields due to the "compass" effect on the gimbal. The test data will be presented and discussed. Additionally, rationale for estimating gimbal performance in a zero-G environment will be presented and discussed.

Design and development of integral heat pipe/thermal energy storage devices. [used with spacecraft cryocoolers

NASA Technical Reports Server (NTRS)

Mahefkey, E. T.; Richter, R.

1981-01-01

The major design and performance test subtasks in the development of small (200 to 1,000 whr) integral heat pipe/thermal energy storage devices for use with thermally driven spacecraft cryo-coolers are described. The design of the integral heat pipe/thermal energy storage device was based on a quasi steady resistance heat transfer, lumped capacitance model. Design considerations for the heat pipe and thermal storage annuli are presented. The thermomechanical stress and insulation system design for the device are reviewed. Experimental correlations are described, as are the plans for the further development of the concept.

Design and development of integral heat pipe/thermal energy storage devices

NASA Astrophysics Data System (ADS)

Mahefkey, E. T.; Richter, R.

1981-06-01

The major design and performance test subtasks in the development of small (200 to 1,000 whr) integral heat pipe/thermal energy storage devices for use with thermally driven spacecraft cryo-coolers are described. The design of the integral heat pipe/thermal energy storage device was based on a quasi steady resistance heat transfer, lumped capacitance model. Design considerations for the heat pipe and thermal storage annuli are presented. The thermomechanical stress and insulation system design for the device are reviewed. Experimental correlations are described, as are the plans for the further development of the concept.

More than Just Test Scores: Leading for Improvement with an Alternative Community-Driven Accountability Metric

ERIC Educational Resources Information Center

Spain, Angeline; McMahon, Kelly

2016-01-01

In this case, Sharon Rowley, a veteran principal, volunteers to participate in a new community-driven accountability initiative and encounters dilemmas about what it means to be a "data-driven" instructional leader. This case provides an opportunity for aspiring school leaders to explore and apply data-use theory to the work of leading…

School Budgeting and School Performance: The Impact of New York City's Performance Driven Budgeting Initiative.

ERIC Educational Resources Information Center

Stiefel, Leanna; Schwartz, Amy Ellen; Portas, Carole; Kim, Dae Yeop

2003-01-01

Analyzes the impact of Performance Driven Budgeting (PDB), a school-based budgeting initiative, on student test scores in the fourth and fifth grades and on spending patterns in selected New York City schools. Finds that PDB has a positive effect on some student test scores and leads to a change in the mix of spending, but not its level. (Contains…

Development of virtual reality exercise of hand motion assist robot for rehabilitation therapy by patient self-motion control.

PubMed

Ueki, Satoshi; Nishimoto, Yutaka; Abe, Motoyuki; Kawasaki, Haruhisa; Ito, Satoshi; Ishigure, Yasuhiko; Mizumoto, Jun; Ojika, Takeo

2008-01-01

This paper presents a virtual reality-enhanced hand rehabilitation support system with a symmetric master-slave motion assistant for independent rehabilitation therapies. Our aim is to provide fine motion exercise for a hand and fingers, which allows the impaired hand of a patient to be driven by his or her healthy hand on the opposite side. Since most disabilities caused by cerebral vascular accidents or bone fractures are hemiplegic, we adopted a symmetric master-slave motion assistant system in which the impaired hand is driven by the healthy hand on the opposite side. A VR environment displaying an effective exercise was created in consideration of system's characteristic. To verify the effectiveness of this system, a clinical test was executed by applying to six patients.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Juanes, Ruben

The overarching goal of this project was to develop a new continuum theory of multiphase flow in porous media. The theory follows a phase-field modeling approach, and therefore has a sound thermodynamical basis. It is a phenomenological theory in the sense that its formulation is driven by macroscopic phenomena, such as viscous instabilities during multifluid displacement. The research agenda was organized around a set of hypothesis on hitherto unexplained behavior of multiphase flow. All these hypothesis are nontrivial, and testable. Indeed, a central aspect of the project was testing each hypothesis by means of carefully-designed laboratory experiments, therefore probing themore » validity of the proposed theory. The proposed research places an emphasis on the fundamentals of flow physics, but is motivated by important energy-driven applications in earth sciences, as well as microfluidic technology.« less

Information-driven trade and price-volume relationship in artificial stock markets

NASA Astrophysics Data System (ADS)

Liu, Xinghua; Liu, Xin; Liang, Xiaobei

2015-07-01

The positive relation between stock price changes and trading volume (price-volume relationship) as a stylized fact has attracted significant interest among finance researchers and investment practitioners. However, until now, consensus has not been reached regarding the causes of the relationship based on real market data because extracting valuable variables (such as information-driven trade volume) from real data is difficult. This lack of general consensus motivates us to develop a simple agent-based computational artificial stock market where extracting the necessary variables is easy. Based on this model and its artificial data, our tests have found that the aggressive trading style of informed agents can produce a price-volume relationship. Therefore, the information spreading process is not a necessary condition for producing price-volume relationship.

Ways to improve the efficiency and reliability of radio frequency driven negative ion sources for fusion.

PubMed

Kraus, W; Briefi, S; Fantz, U; Gutmann, P; Doerfler, J

2014-02-01

Large RF driven negative hydrogen ion sources are being developed at IPP Garching for the future neutral beam injection system of ITER. The overall power efficiency of these sources is low, because for the RF power supply self-excited generators are utilized and the plasma is generated in small cylindrical sources ("drivers") and expands into the source main volume. At IPP experiments to reduce the primary power and the RF power required for the plasma production are performed in two ways: The oscillator generator of the prototype source has been replaced by a transistorized RF transmitter and two alternative driver concepts, a spiral coil, in which the field is concentrated by ferrites, which omits the losses by plasma expansion and a helicon source are being tested.

Laser-driven injector of electrons for IOTA

NASA Astrophysics Data System (ADS)

Romanov, Aleksandr

2017-03-01

Fermilab is developing the Integrable Optics Test Accelerator (IOTA) ring for experiments on nonlinear integrable optics. The machine will operate with either electron beams of 150 MeV or proton beams of 2.5 MeV energies, respectively. The stability of integrable optics depends critically on the precision of the magnetic lattice, which demands the use of beam-based lattice measurements for optics correction. In the proton mode, the low-energy proton beam does not represent a good probe for this application; hence we consider the use of a low-intensity reverse-injected electron beam of matched momentum (70 MeV). Such an injector could be implemented with the use of laser-driven acceleration techniques. This report presents the consideration for a laser-plasma injector for IOTA and discusses the requirements determined by the ring design.

Generating Electricity during Walking with a Lower Limb-Driven Energy Harvester: Targeting a Minimum User Effort

PubMed Central

Shepertycky, Michael; Li, Qingguo

2015-01-01

Background Much research in the field of energy harvesting has sought to develop devices capable of generating electricity during daily activities with minimum user effort. No previous study has considered the metabolic cost of carrying the harvester when determining the energetic effects it has on the user. When considering device carrying costs, no energy harvester to date has demonstrated the ability to generate a substantial amount of electricity (> 5W) while maintaining a user effort at the same level or lower than conventional power generation methods (e.g. hand crank generator). Methodology/Principal Findings We developed a lower limb-driven energy harvester that is able to generate approximately 9W of electricity. To quantify the performance of the harvester, we introduced a new performance measure, total cost of harvesting (TCOH), which evaluates a harvester’s overall efficiency in generating electricity including the device carrying cost. The new harvester captured the motion from both lower limbs and operated in the generative braking mode to assist the knee flexor muscles in slowing the lower limbs. From a testing on 10 participants under different walking conditions, the harvester achieved an average TCOH of 6.1, which is comparable to the estimated TCOH for a conventional power generation method of 6.2. When generating 5.2W of electricity, the TCOH of the lower limb-driven energy harvester (4.0) is lower than that of conventional power generation methods. Conclusions/Significance These results demonstrated that the lower limb-driven energy harvester is an energetically effective option for generating electricity during daily activities. PMID:26039493

Generating Electricity during Walking with a Lower Limb-Driven Energy Harvester: Targeting a Minimum User Effort.

PubMed

Shepertycky, Michael; Li, Qingguo

2015-01-01

Much research in the field of energy harvesting has sought to develop devices capable of generating electricity during daily activities with minimum user effort. No previous study has considered the metabolic cost of carrying the harvester when determining the energetic effects it has on the user. When considering device carrying costs, no energy harvester to date has demonstrated the ability to generate a substantial amount of electricity (> 5W) while maintaining a user effort at the same level or lower than conventional power generation methods (e.g. hand crank generator). We developed a lower limb-driven energy harvester that is able to generate approximately 9W of electricity. To quantify the performance of the harvester, we introduced a new performance measure, total cost of harvesting (TCOH), which evaluates a harvester's overall efficiency in generating electricity including the device carrying cost. The new harvester captured the motion from both lower limbs and operated in the generative braking mode to assist the knee flexor muscles in slowing the lower limbs. From a testing on 10 participants under different walking conditions, the harvester achieved an average TCOH of 6.1, which is comparable to the estimated TCOH for a conventional power generation method of 6.2. When generating 5.2W of electricity, the TCOH of the lower limb-driven energy harvester (4.0) is lower than that of conventional power generation methods. These results demonstrated that the lower limb-driven energy harvester is an energetically effective option for generating electricity during daily activities.

Special Operations Forces: Opportunities Exist to Improve Transparency of Funding and Assess Potential to Lessen Some Deployments

DTIC Science & Technology

2015-07-01

pace of special operations deployments, but opportunities may exist to better balance the workload across the joint force because activities...executes funding in operation and maintenance; procurement; research , development, test, and evaluation; and military construction accounts.13 SOCOM...regional awareness. Moreover, officials noted that increases in civilian positions were driven partly by DOD’s attempts to rebalance workload and become a

Saclay Compact Accelerator-driven Neutron Sources (SCANS)

NASA Astrophysics Data System (ADS)

Marchix, A.; Letourneau, A.; Tran, HN; Chauvin, N.; Menelle, A.; Ott, F.; Schwindling, J.

2018-06-01

For next decade, the European neutron scattering community will face of important changes, as many facilities will close, strictly fission-based sources. This statement mainly concerns France with the planned closure of Orphee and ILL. At CEA-Saclay, the project SONATE has been launched in order to provide a high intensity neutron source in Saclay site, this project is based on Compact Accelerator-driven Neutron Sources technology coupled to high-intensity beams. The goal of SONATE is to develop a 50 kW target, aiming to produce at least a neutron yield of 1013 s-1 in pulse mode with a peak current of 100 mA. We have investigated in this document the best combinations of beam/target which would lead to this substantial neutron yields. Further investigations and tests have to be carry out, especially due to sparse data on thick target and such low-energy beams considered in this document. An intermediate step to the SONATE project is under test and development, called IPHI-NEUTRON, which would lead to provide a small-size neutron facility mainly devoted to neutron imagery for industry. This step is based on the existing 3 MeV proton beam, named IPHI. Best target candidates are Lithium and Beryllium, leading respectively to a neutron yield of about 2.1013 s-1 and 4.1012 s-1.

A Microwave Driven Ion Source for Continuous-Flow AMS (Abstract)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wills, J.; Schneider, R.J.; Reden, K.F. von

2005-03-15

A microwave-driven, gas-fed ion source originally developed as a high-current positive ion injector for a Tandem accelerator at Chalk River has been the subject of a three-year development program at the Woods Hole Oceanographic Institution NOSAMS facility. Off-line tests have demonstrated positive carbon currents of 1 mA and negative carbon currents of 80 {mu}A from CO2 gas feed. This source and a magnesium charge-exchange canal were coupled to the recombinator of the NOSAMS Tandetron for on-line tests, with the source fed with reference gasses and a combustion device.The promising results obtained have prompted the redesign of the microwave source formore » use as an on-line, continuous-flow injector for a new AMS facility under construction at NOSAMS. The new design is optimized for best transmission of the extracted positive-ion beam through the charge-exchange canal and for reliable operation at 40 kV extraction voltage. Other goals of the re-design include improved lifetime of the microwave window and the elimination of dead volumes in the plasma generator that increase sample hold-up time.This talk will include a summary of results obtained to date at NOSAMS with the Chalk River source and a detailed description of the new design.« less

Towards a Job Demands-Resources Health Model: Empirical Testing with Generalizable Indicators of Job Demands, Job Resources, and Comprehensive Health Outcomes.

PubMed

Brauchli, Rebecca; Jenny, Gregor J; Füllemann, Désirée; Bauer, Georg F

2015-01-01

Studies using the Job Demands-Resources (JD-R) model commonly have a heterogeneous focus concerning the variables they investigate-selective job demands and resources as well as burnout and work engagement. The present study applies the rationale of the JD-R model to expand the relevant outcomes of job demands and job resources by linking the JD-R model to the logic of a generic health development framework predicting more broadly positive and negative health. The resulting JD-R health model was operationalized and tested with a generalizable set of job characteristics and positive and negative health outcomes among a heterogeneous sample of 2,159 employees. Applying a theory-driven and a data-driven approach, measures which were generally relevant for all employees were selected. Results from structural equation modeling indicated that the model fitted the data. Multiple group analyses indicated invariance across six organizations, gender, job positions, and three times of measurement. Initial evidence was found for the validity of an expanded JD-R health model. Thereby this study contributes to the current research on job characteristics and health by combining the core idea of the JD-R model with the broader concepts of salutogenic and pathogenic health development processes as well as both positive and negative health outcomes.

Just-in-time Database-Driven Web Applications

PubMed Central

2003-01-01

"Just-in-time" database-driven Web applications are inexpensive, quickly-developed software that can be put to many uses within a health care organization. Database-driven Web applications garnered 73873 hits on our system-wide intranet in 2002. They enabled collaboration and communication via user-friendly Web browser-based interfaces for both mission-critical and patient-care-critical functions. Nineteen database-driven Web applications were developed. The application categories that comprised 80% of the hits were results reporting (27%), graduate medical education (26%), research (20%), and bed availability (8%). The mean number of hits per application was 3888 (SD = 5598; range, 14-19879). A model is described for just-in-time database-driven Web application development and an example given with a popular HTML editor and database program. PMID:14517109

Analyses of transients for an 800 MW-class accelerator driven transmuter with fertile-free fuels

NASA Astrophysics Data System (ADS)

Maschek, Werner; Suzuki, Tohru; Chen, Xue-Nong; Rineiski, Andrei; Matzerath Boccaccini, Claudia; Mori, Magnus; Morita, Koji

2006-06-01

In the FUTURE Program, the development and application of fertile-free fuels for Accelerator Driven Transmuters (ADTs) has been advanced. To assess the reactor performance and safety behavior of an ADT with so-called dedicated fuels, various transient cases for an 800 MW-class Pb/Bi-cooled ADT were investigated using the SIMMER-III code. The FUTURE ADT also served as vehicle to develop and test ideas on a safety concept for such transmuters. After an extensive ranking procedure, a CERCER fuel with an MgO matrix and a CERMET fuel with a Mo-92 matrix were chosen. The transient scenarios shown here are: spurious beam trip (BT), unprotected loss of flow (ULOF) and unprotected blockage accident (UBA). Since the release of fission gas and helium after cladding failure could induce a significant positive reactivity, the gas-blowdown was investigated for the transient scenarios. The present analyses showed that power excursions could be avoided by the fuel sweep-out from the core under severe accident conditions.

A Humidity-Driven Prediction System for Influenza Outbreaks

NASA Astrophysics Data System (ADS)

Thrastarson, H. T.; Teixeira, J.

2015-12-01

Recent studies have highlighted the role of absolute (or specific) humidity conditions as a leading explanation for the seasonal behavior of influenza outbreaks in temperate regions. If the timing and intensity of seasonal influenza outbreaks can be forecast, this would be of great value for public health response efforts. We have developed and implemented a SIRS (Susceptible-Infectious-Recovered-Susceptible) type numerical prediction system that is driven by specific humidity to predict influenza outbreaks. For the humidity, we have explored using both satellite data from the AIRS (Atmospheric Infrared Sounder) instrument as well as ERA-Interim re-analysis data. We discuss the development, testing, sensitivities and limitations of the prediction system and show results for influenza outbreaks in the United States during the years 2010-2014 (modeled in retrospect). Comparisons are made with other existing prediction systems and available data for influenza outbreaks from Google Flu Trends and the CDC (Center for Disease Control), and the incorporation of these datasets into the forecasting system is discussed.

Data-Driven Simulation-Enhanced Optimization of People-Based Print Production Service

NASA Astrophysics Data System (ADS)

Rai, Sudhendu

This paper describes a systematic six-step data-driven simulation-based methodology for optimizing people-based service systems on a large distributed scale that exhibit high variety and variability. The methodology is exemplified through its application within the printing services industry where it has been successfully deployed by Xerox Corporation across small, mid-sized and large print shops generating over 250 million in profits across the customer value chain. Each step of the methodology consisting of innovative concepts co-development and testing in partnership with customers, development of software and hardware tools to implement the innovative concepts, establishment of work-process and practices for customer-engagement and service implementation, creation of training and infrastructure for large scale deployment, integration of the innovative offering within the framework of existing corporate offerings and lastly the monitoring and deployment of the financial and operational metrics for estimating the return-on-investment and the continual renewal of the offering are described in detail.

Neuroscience-driven discovery and development of sleep therapeutics.

PubMed

Dresler, M; Spoormaker, V I; Beitinger, P; Czisch, M; Kimura, M; Steiger, A; Holsboer, F

2014-03-01

Until recently, neuroscience has given sleep research and discovery of better treatments of sleep disturbances little attention, despite the fact that disturbed sleep has overwhelming impact on human health. Sleep is a complex phenomenon in which specific psychological, electrophysiological, neurochemical, endocrinological, immunological and genetic factors are involved. The brain as both the generator and main object of sleep is obviously of particular interest, which makes a neuroscience-driven view the most promising approach to evaluate clinical implications and applications of sleep research. Polysomnography as the gold standard of sleep research, complemented by brain imaging, neuroendocrine testing, genomics and other laboratory measures can help to create composite biomarkers that allow maximizing the effects of individualized therapies while minimizing adverse effects. Here we review the current state of the neuroscience of sleep, sleep disorders and sleep therapeutics and will give some leads to promote the discovery and development of sleep medicines that are better than those we have today. Copyright © 2013 Elsevier Inc. All rights reserved.

Compact and tunable focusing device for plasma wakefield acceleration

NASA Astrophysics Data System (ADS)

Pompili, R.; Anania, M. P.; Chiadroni, E.; Cianchi, A.; Ferrario, M.; Lollo, V.; Notargiacomo, A.; Picardi, L.; Ronsivalle, C.; Rosenzweig, J. B.; Shpakov, V.; Vannozzi, A.

2018-03-01

Plasma wakefield acceleration, either driven by ultra-short laser pulses or electron bunches, represents one of the most promising techniques able to overcome the limits of conventional RF technology and allows the development of compact accelerators. In the particle beam-driven scenario, ultra-short bunches with tiny spot sizes are required to enhance the accelerating gradient and preserve the emittance and energy spread of the accelerated bunch. To achieve such tight transverse beam sizes, a focusing system with short focal length is mandatory. Here we discuss the development of a compact and tunable system consisting of three small-bore permanent-magnet quadrupoles with 520 T/m field gradient. The device has been designed in view of the plasma acceleration experiments planned at the SPARC_LAB test-facility. Being the field gradient fixed, the focusing is adjusted by tuning the relative position of the three magnets with nanometer resolution. Details about its magnetic design, beam-dynamics simulations, and preliminary results are examined in the paper.

Attack of the Killer Fungus: A Hypothesis-Driven Lab Module †

PubMed Central

Sato, Brian K.

2013-01-01

Discovery-driven experiments in undergraduate laboratory courses have been shown to increase student learning and critical thinking abilities. To this end, a lab module involving worm capture by a nematophagous fungus was developed. The goals of this module are to enhance scientific understanding of the regulation of worm capture by soil-dwelling fungi and for students to attain a set of established learning goals, including the ability to develop a testable hypothesis and search for primary literature for data analysis, among others. Students in a ten-week majors lab course completed the lab module and generated novel data as well as data that agrees with the published literature. In addition, learning gains were achieved as seen through a pre-module and post-module test, student self-assessment, class exam, and lab report. Overall, this lab module enables students to become active participants in the scientific method while contributing to the understanding of an ecologically relevant model organism. PMID:24358387

Quantifying Instability Sources in Liquid Rocket Engines

NASA Technical Reports Server (NTRS)

Farmer, Richard C.; Cheng, Gary C.

2000-01-01

Computational fluid dynamics methodology to predict the effects of combusting flows on acoustic pressure oscillations in liquid rocket engines (LREs) is under development. 'Me intent of the investigation is to develop the causal physics of combustion driven acoustic resonances in LREs. The crux of the analysis is the accurate simulation of pressure/density/sound speed in a combustor which when used by the FDNS-RFV CFD code will produce realistic flow phenomena. An analysis of a gas generator considered for the Fastrac engine will be used as a test validation case.

A Preliminary Study of the Effects of a Multitheory-Driven Intervention in Adults With Prediabetes Mellitus.

PubMed

Tsai, Fu-Mian; Lin, Chiu-Chu; Lin, Huey-Shyan; Liu, Yi

2018-06-01

Prediabetes mellitus (pre-DM) is an important predictive indicator of Type 2 diabetes. A person with pre-DM is eight times more likely to develop diabetes than a person without pre-DM. Prior research suggests that proactive interventions may delay the progression of this disease and reduce the rate of disease development. The purposes of this preliminary study were to develop a multitheory-driven lifestyle intervention protocol for adults with pre-DM and to evaluate its feasibility and impacts on knowledge regarding pre-DM, dietary behaviors, and physical activity (primary outcomes) as well as to describe the disease progression indicators (secondary outcomes). A single-group, longitudinal study design was used. Thirty-nine participants were included in the analysis. A generalized estimating equation model was used to determine the trends in changes in the outcomes. All of the participants underwent testing at baseline (T0) and at 3 (T1), 6 (T2), and 12 (T3) months after the 4-week lifestyle intervention. There were significantly increasing trends for each study parameter (Pre-DM Knowledge Assessment Form-12, p < .01; Dietary Behavior Scale, p < .01) and significantly positive changes in body weight (p < .01), body mass index (p < .01), fasting glucose level (p < .01), and glycated hemoglobin level (p < .01) over the 12-month study period. This study supports the feasibility of the developed multitheory-driven lifestyle intervention protocol and suggests that its application may improve the effectiveness of diabetes prevention programs in clinical settings. Further randomized controlled trials are needed.

Theory-driven research in pediatric psychology: a little bit on why and how.

PubMed

Wallander, J L

1992-10-01

Introduces a Special Issue, covering two published issues (5 and 6) of this journal, on theory-driven research in pediatric psychology. A rationale for conducting research from a conceptual basis is presented. It is emphasized that science is primarily an intellectual activity, demonstrated in the form of theory building, testing, and reformulation. Furthermore, it is argued theory serves as a planning and communication aide for scientific pursuit. The process and components of theory-driven research are then highlighted. Theoretical constructs, theoretical and empirical definitions of constructs, and the use of variables are discussed. A definition of scientific theory is offered. Theory testing is distinguished from post hoc theorizing. Differences in the scope of theories are noted. Connections between theory and hypothesis testing and research design are addressed, especially for nonexperimental or correlational research.

Lack of promoter IV-driven BDNF transcription results in depression-like behavior.

PubMed

Sakata, K; Jin, L; Jha, S

2010-10-01

Transcription of Bdnf is controlled by multiple promoters, in which promoter IV contributes significantly to activity-dependent Bdnf transcription. We have generated promoter IV mutant mice [brain-derived neurotrophic factor (BDNF)-KIV] in which promoter IV-driven expression of BDNF is selectively disrupted by inserting a green fluorescent protein (GFP)-STOP cassette within the Bdnf exon IV locus. BDNF-KIV animals exhibited depression-like behavior as shown by the tail suspension test (TST), sucrose preference test (SPT) and learned helplessness test (LHT). In addition, BDNF-KIV mice showed reduced activity in the open field test (OFT) and reduced food intake in the novelty-suppressed feeding test (NSFT). The mutant mice did not display anxiety-like behavior in the light and dark box test and elevated plus maze tests. Interestingly, the mutant mice showed defective response inhibition in the passive avoidance test (PAT) even though their learning ability was intact when measured with the active avoidance test (AAT). These results suggest that promoter IV-dependent BDNF expression plays a critical role in the control of mood-related behaviors. This is the first study that directly addressed the effects of endogenous promoter-driven expression of BDNF in depression-like behavior. © 2010 The Authors. Genes, Brain and Behavior © 2010 Blackwell Publishing Ltd and International Behavioural and Neural Genetics Society.

Control of movement initiation underlies the development of balance

PubMed Central

Ehrlich, David E.; Schoppik, David

2017-01-01

Summary Balance arises from the interplay of external forces acting on the body and internally generated movements. Many animal bodies are inherently unstable, necessitating corrective locomotion to maintain stability. Understanding how developing animals come to balance remains a challenge. Here we study the interplay between environment, sensation, and action as balance develops in larval zebrafish. We first model the physical forces that challenge underwater balance and experimentally confirm that larvae are subject to constant destabilization. Larvae propel in swim bouts that, we find, tend to stabilize the body. We confirm the relationship between locomotion and balance by changing larval body composition, exacerbating instability and eliciting more frequent swimming. Intriguingly, developing zebrafish come to control the initiation of locomotion, swimming preferentially when unstable, thus restoring preferred postures. To test the sufficiency of locomotor-driven stabilization and the developing control of movement timing, we incorporate both into a generative model of swimming. Simulated larvae recapitulate observed postures and movement timing across early development, but only when locomotor-driven stabilization and control of movement initiation are both utilized. We conclude the ability to move when unstable is the key developmental improvement to balance in larval zebrafish. Our work informs how emerging sensorimotor ability comes to impact how and why animals move when they do. PMID:28111151

Wingless is a positive regulator of eyespot color patterns in Bicyclus anynana butterflies.

PubMed

Özsu, Nesibe; Chan, Qian Yi; Chen, Bin; Gupta, Mainak Das; Monteiro, Antónia

2017-09-01

Eyespot patterns of nymphalid butterflies are an example of a novel trait yet, the developmental origin of eyespots is still not well understood. Several genes have been associated with eyespot development but few have been tested for function. One of these genes is the signaling ligand, wingless, which is expressed in the eyespot centers during early pupation and may function in eyespot signaling and color ring differentiation. Here we tested the function of wingless in wing and eyespot development by down-regulating it in transgenic Bicyclus anynana butterflies via RNAi driven by an inducible heat-shock promoter. Heat-shocks applied during larval and early pupal development led to significant decreases in wingless mRNA levels and to decreases in eyespot size and wing size in adult butterflies. We conclude that wingless is a positive regulator of eyespot and wing development in B. anynana butterflies. Copyright © 2017 Elsevier Inc. All rights reserved.

A miniature cable-driven robot for crawling on the heart.

PubMed

Patronik, N A; Zenati, M A; Riviere, C N

2005-01-01

This document describes the design and preliminary testing of a cable-driven robot for the purpose of traveling on the surface of the beating heart to administer therapy. This methodology obviates mechanical stabilization and lung deflation, which are typically required during minimally invasive cardiac surgery. Previous versions of the robot have been remotely actuated through push-pull wires, while visual feedback was provided by fiber optic transmission. Although these early models were able to perform locomotion in vivo on porcine hearts, the stiffness of the wire-driven transmission and fiber optic camera limited the mobility of the robots. The new prototype described in this document is actuated by two antagonistic cable pairs, and contains a color CCD camera located in the front section of the device. These modifications have resulted in superior mobility and visual feedback. The cable-driven prototype has successfully demonstrated prehension, locomotion, and tissue dye injection during in vitro testing with a poultry model.

A Urinalysis Result Reporting System for a Clinical Laboratory

PubMed Central

Sullivan, James E.; Plexico, Perry S.; Blank, David W.

1987-01-01

A menu driven Urinalysis Result Reporting System based on multiple IBM-PC Workstations connected together by a local area network was developed for the Clinical Chemistry Section of the Clinical Pathology Department at the National Institutes of Health's Clinical Center. Two Network File Servers redundantly save the test results of each urine specimen. When all test results for a specimen are entered into the system, the results are transmitted to the Department's Laboratory Computer System where they are made available to the ordering physician. The Urinalysis Data Management System has proven easy to learn and use.

Data-driven battery product development: Turn battery performance into a competitive advantage.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sholklapper, Tal

Poor battery performance is a primary source of user dissatisfaction across a broad range of applications, and is a key bottleneck hindering the growth of mobile technology, wearables, electric vehicles, and grid energy storage. Engineering battery systems is difficult, requiring extensive testing for vendor selection, BMS programming, and application-specific lifetime testing. This work also generates huge quantities of data. This presentation will explain how to leverage this data to help ship quality products faster using fewer resources while ensuring safety and reliability in the field, ultimately turning battery performance into a competitive advantage.

The Iterative Design Process in Research and Development: A Work Experience Paper

NASA Technical Reports Server (NTRS)

Sullivan, George F. III

2013-01-01

The iterative design process is one of many strategies used in new product development. Top-down development strategies, like waterfall development, place a heavy emphasis on planning and simulation. The iterative process, on the other hand, is better suited to the management of small to medium scale projects. Over the past four months, I have worked with engineers at Johnson Space Center on a multitude of electronics projects. By describing the work I have done these last few months, analyzing the factors that have driven design decisions, and examining the testing and verification process, I will demonstrate that iterative design is the obvious choice for research and development projects.

The Financial and Non-Financial Aspects of Developing a Data-Driven Decision-Making Mindset in an Undergraduate Business Curriculum

ERIC Educational Resources Information Center

Bohler, Jeffrey; Krishnamoorthy, Anand; Larson, Benjamin

2017-01-01

Making data-driven decisions is becoming more important for organizations faced with confusing and often contradictory information available to them from their operating environment. This article examines one college of business' journey of developing a data-driven decision-making mindset within its undergraduate curriculum. Lessons learned may be…

Fluoride-fiber-based side-pump coupler for high-power fiber lasers at 2.8  μm.

PubMed

Schäfer, C A; Uehara, H; Konishi, D; Hattori, S; Matsukuma, H; Murakami, M; Shimizu, S; Tokita, S

2018-05-15

A side-pump coupler made of fluoride fibers was fabricated and tested. The tested device had a coupling efficiency of 83% and was driven with an incident pump power of up to 83.5 W, demonstrating high-power operation. Stable laser output of 15 W at a wavelength of around 2.8 μm was achieved over 1 h when using an erbium-doped double-clad fiber as the active medium. To the best of our knowledge, this is the first time a fluoride-glass-fiber-based side-pump coupler has been developed. A test with two devices demonstrated further power scalability.

Development and field testing of a Light Aircraft Oil Surveillance System (LAOSS)

NASA Technical Reports Server (NTRS)

Burns, W.; Herz, M. J.

1976-01-01

An experimental device consisting of a conventional TV camera with a low light level photo image tube and motor driven polarized filter arrangement was constructed to provide a remote means of discriminating the presence of oil on water surfaces. This polarized light filtering system permitted a series of successive, rapid changes between the vertical and horizontal components of reflected polarized skylight and caused the oil based substances to be more easily observed and identified as a flashing image against a relatively static water surface background. This instrument was flight tested, and the results, with targets of opportunity and more systematic test site data, indicate the potential usefulness of this airborne remote sensing instrument.

Alternative Test Methods for Developmental Neurotoxicity: A ...

EPA Pesticide Factsheets

Exposure to environmental contaminants is well documented to adversely impact the development of the nervous system. However, the time, animal and resource intensive EPA and OECD testing guideline methods for developmental neurotoxicity (DNT) are not a viable solution to characterizing potential chemical hazards for the thousands of untested chemicals currently in commerce. Thus, research efforts over the past decade have endeavored to develop cost-effective alternative DNT testing methods. These efforts have begun to generate data that can inform regulatory decisions. Yet there are major challenges to both the acceptance and use of this data. Major scientific challenges for DNT include development of new methods and models that are “fit for purpose”, development of a decision-use framework, and regulatory acceptance of the methods. It is critical to understand that use of data from these methods will be driven mainly by the regulatory problems being addressed. Some problems may be addressed with limited datasets, while others may require data for large numbers of chemicals, or require the development and use of new biological and computational models. For example mechanistic information derived from in vitro DNT assays can be used to inform weight of evidence (WoE) or integrated approaches to testing and assessment (IATA) approaches for chemical-specific assessments. Alternatively, in vitro data can be used to prioritize (for further testing) the thousands

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA).

PubMed

Tollefsen, Knut Erik; Scholz, Stefan; Cronin, Mark T; Edwards, Stephen W; de Knecht, Joop; Crofton, Kevin; Garcia-Reyero, Natalia; Hartung, Thomas; Worth, Andrew; Patlewicz, Grace

2014-12-01

Chemical regulation is challenged by the large number of chemicals requiring assessment for potential human health and environmental impacts. Current approaches are too resource intensive in terms of time, money and animal use to evaluate all chemicals under development or already on the market. The need for timely and robust decision making demands that regulatory toxicity testing becomes more cost-effective and efficient. One way to realize this goal is by being more strategic in directing testing resources; focusing on chemicals of highest concern, limiting testing to the most probable hazards, or targeting the most vulnerable species. Hypothesis driven Integrated Approaches to Testing and Assessment (IATA) have been proposed as practical solutions to such strategic testing. In parallel, the development of the Adverse Outcome Pathway (AOP) framework, which provides information on the causal links between a molecular initiating event (MIE), intermediate key events (KEs) and an adverse outcome (AO) of regulatory concern, offers the biological context to facilitate development of IATA for regulatory decision making. This manuscript summarizes discussions at the Workshop entitled "Advancing AOPs for Integrated Toxicology and Regulatory Applications" with particular focus on the role AOPs play in informing the development of IATA for different regulatory purposes. Copyright © 2014 Elsevier Inc. All rights reserved.

On the formation of Friedlander waves in a compressed-gas-driven shock tube

PubMed Central

Tasissa, Abiy F.; Hautefeuille, Martin; Fitek, John H.; Radovitzky, Raúl A.

2016-01-01

Compressed-gas-driven shock tubes have become popular as a laboratory-scale replacement for field blast tests. The well-known initial structure of the Riemann problem eventually evolves into a shock structure thought to resemble a Friedlander wave, although this remains to be demonstrated theoretically. In this paper, we develop a semi-analytical model to predict the key characteristics of pseudo blast waves forming in a shock tube: location where the wave first forms, peak over-pressure, decay time and impulse. The approach is based on combining the solutions of the two different types of wave interactions that arise in the shock tube after the family of rarefaction waves in the Riemann solution interacts with the closed end of the tube. The results of the analytical model are verified against numerical simulations obtained with a finite volume method. The model furnishes a rational approach to relate shock tube parameters to desired blast wave characteristics, and thus constitutes a useful tool for the design of shock tubes for blast testing. PMID:27118888

How to develop a theory-driven evaluation design? Lessons learned from an adolescent sexual and reproductive health programme in West Africa.

PubMed

Van Belle, Sara B; Marchal, Bruno; Dubourg, Dominique; Kegels, Guy

2010-11-30

This paper presents the development of a study design built on the principles of theory-driven evaluation. The theory-driven evaluation approach was used to evaluate an adolescent sexual and reproductive health intervention in Mali, Burkina Faso and Cameroon to improve continuity of care through the creation of networks of social and health care providers. Based on our experience and the existing literature, we developed a six-step framework for the design of theory-driven evaluations, which we applied in the ex-post evaluation of the networking component of the intervention. The protocol was drafted with the input of the intervention designer. The programme theory, the central element of theory-driven evaluation, was constructed on the basis of semi-structured interviews with designers, implementers and beneficiaries and an analysis of the intervention's logical framework. The six-step framework proved useful as it allowed for a systematic development of the protocol. We describe the challenges at each step. We found that there is little practical guidance in the existing literature, and also a mix up of terminology of theory-driven evaluation approaches. There is a need for empirical methodological development in order to refine the tools to be used in theory driven evaluation. We conclude that ex-post evaluations of programmes can be based on such an approach if the required information on context and mechanisms is collected during the programme.

How to develop a theory-driven evaluation design? Lessons learned from an adolescent sexual and reproductive health programme in West Africa

PubMed Central

2010-01-01

Background This paper presents the development of a study design built on the principles of theory-driven evaluation. The theory-driven evaluation approach was used to evaluate an adolescent sexual and reproductive health intervention in Mali, Burkina Faso and Cameroon to improve continuity of care through the creation of networks of social and health care providers. Methods/design Based on our experience and the existing literature, we developed a six-step framework for the design of theory-driven evaluations, which we applied in the ex-post evaluation of the networking component of the intervention. The protocol was drafted with the input of the intervention designer. The programme theory, the central element of theory-driven evaluation, was constructed on the basis of semi-structured interviews with designers, implementers and beneficiaries and an analysis of the intervention's logical framework. Discussion The six-step framework proved useful as it allowed for a systematic development of the protocol. We describe the challenges at each step. We found that there is little practical guidance in the existing literature, and also a mix up of terminology of theory-driven evaluation approaches. There is a need for empirical methodological development in order to refine the tools to be used in theory driven evaluation. We conclude that ex-post evaluations of programmes can be based on such an approach if the required information on context and mechanisms is collected during the programme. PMID:21118510

A Model-Driven Development Method for Management Information Systems

NASA Astrophysics Data System (ADS)

Mizuno, Tomoki; Matsumoto, Keinosuke; Mori, Naoki

Traditionally, a Management Information System (MIS) has been developed without using formal methods. By the informal methods, the MIS is developed on its lifecycle without having any models. It causes many problems such as lack of the reliability of system design specifications. In order to overcome these problems, a model theory approach was proposed. The approach is based on an idea that a system can be modeled by automata and set theory. However, it is very difficult to generate automata of the system to be developed right from the start. On the other hand, there is a model-driven development method that can flexibly correspond to changes of business logics or implementing technologies. In the model-driven development, a system is modeled using a modeling language such as UML. This paper proposes a new development method for management information systems applying the model-driven development method to a component of the model theory approach. The experiment has shown that a reduced amount of efforts is more than 30% of all the efforts.

Identification and Analysis of Technology Emergence Using Patent Classification

DTIC Science & Technology

2014-01-01

and legal time and capital. The desired payoff for this investment is monopolistic control of a section of the technology space, allowed by present...the claims of their application based on either the prior art cited by the patent examiner or economic reali- ties surrounding the markets for...have been developed, the claims of the patents have been tuned and tested at the respective patent office, and market -driven commercial realities may

Study on the CO2 electric driven fixed swash plate type compressor for eco-friendly vehicles

NASA Astrophysics Data System (ADS)

Nam, Donglim; Kim, Kitae; Lee, Jehie; Kwon, Yunki; Lee, Geonho

2017-08-01

The purpose of this study is to experiment and to performance analysis about the electric-driven fixed swash plate compressor using alternate refrigerant(R744). Comprehensive simulation model for an electric driven compressor using CO2 for eco-friendly vehicle is presented. This model consists of compression model and dynamic model. The compression model included valve dynamics, leakage, and heat transfer models. And the dynamic model included frictional loss between piston ring and cylinder wall, frictional loss between shoe and swash plate, frictional loss of bearings, and electric efficiency. Especially, because the efficiency of an electric parts(motor and inverter) in the compressor affects the loss of the compressor, the dynamo test was performed. We made the designed compressor, and tested the performance of the compressor about the variety pressure conditions. Also we compared the performance analysis result and performance test result.

New Roads for Patron-Driven E-Books: Collection Development and Technical Services Implications of a Patron-Driven Acquisitions Pilot at Rutgers

ERIC Educational Resources Information Center

De Fino, Melissa; Lo, Mei Ling

2011-01-01

Collection development librarians have long struggled to meet user demands for new titles. Too often, required resources are not purchased, whereas some purchased resources do not circulate. E-books selected through patron-driven plans are a solution but present new challenges for both selectors and catalogers. Radical changes to traditional…

Event-Driven X-Ray CCD Detectors for High Energy Astrophysics

NASA Technical Reports Server (NTRS)

Ricker, George R.

2004-01-01

A viewgraph presentation describing the Event-Driven X- Ray CCD (EDCCD) detector system for high energy astrophysics is presented. The topics include: 1) EDCCD: Description and Advantages; 2) Summary of Grant Activity Carried Out; and 3) EDCCD Test System.

Computerized organ localization in abdominal CT volume with context-driven generalized Hough transform

NASA Astrophysics Data System (ADS)

Liu, Jing; Li, Qiang

2014-03-01

Fast localization of organs is a key step in computer-aided detection of lesions and in image guided radiation therapy. We developed a context-driven Generalized Hough Transform (GHT) for robust localization of organ-of-interests (OOIs) in a CT volume. Conventional GHT locates the center of an organ by looking-up center locations of pre-learned organs with "matching" edges. It often suffers from mislocalization because "similar" edges in vicinity may attract the prelearned organs towards wrong places. The proposed method not only uses information from organ's own shape but also takes advantage of nearby "similar" edge structures. First, multiple GHT co-existing look-up tables (cLUT) were constructed from a set of training shapes of different organs. Each cLUT represented the spatial relationship between the center of the OOI and the shape of a co-existing organ. Second, the OOI center in a test image was determined using GHT with each cLUT separately. Third, the final localization of OOI was based on weighted combination of the centers obtained in the second stage. The training set consisted of 10 CT volumes with manually segmented OOIs including liver, spleen and kidneys. The method was tested on a set of 25 abdominal CT scans. Context-driven GHT correctly located all OOIs in the test image and gave localization errors of 19.5±9.0, 12.8±7.3, 9.4±4.6 and 8.6±4.1 mm for liver, spleen, left and right kidney respectively. Conventional GHT mis-located 8 out of 100 organs and its localization errors were 26.0±32.6, 14.1±10.6, 30.1±42.6 and 23.6±39.7mm for liver, spleen, left and right kidney respectively.

Toward lean satellites reliability improvement using HORYU-IV project as case study

NASA Astrophysics Data System (ADS)

Faure, Pauline; Tanaka, Atomu; Cho, Mengu

2017-04-01

Lean satellite programs are programs in which the satellite development philosophy is driven by fast delivery and low cost. Though this concept offers the possibility to develop and fly risky missions without jeopardizing a space program, most of these satellites suffer infant mortality and fail to achieve their mission minimum success. Lean satellites with high infant mortality rate indicate that testing prior to launch is insufficient. In this study, the authors monitored failures occurring during the development of the lean satellite HORYU-IV to identify the evolution of the cumulative number of failures against cumulative testing time. Moreover, the sub-systems driving the failures depending on the different development phases were identified. The results showed that half to 2/3 of the failures are discovered during the early stage of testing. Moreover, when the mean time before failure was calculated, it appeared that for any development phase considered, a new failure appears on average every 20 h of testing. Simulations were also performed and it showed that for an initial testing time of 50 h, reliability after 1 month launch can be improved by nearly 6 times as compared to an initial testing time of 20 h. Through this work, the authors aim at providing a qualitative reference for lean satellites developers to better help them manage resources to develop lean satellites following a fast delivery and low cost philosophy while ensuring sufficient reliability to achieve mission minimum success.

US hydropower resource assessment for Hawaii

DOE Office of Scientific and Technical Information (OSTI.GOV)

Francfort, J.E.

1996-09-01

US DOE is developing an estimate of the undeveloped hydropower potential in US. The Hydropower Evaluation Software (HES) is a computer model developed by INEL for this purpose. HES measures the undeveloped hydropower resources available in US, using uniform criteria for measurement. The software was tested using hydropower information and data provided by Southwestern Power Administration. It is a menu-driven program that allows the PC user to assign environmental attributes to potential hydropower sites, calculate development suitability factors for each site based on the environmental attributes, and generate reports. This report describes the resource assessment results for the State ofmore » Hawaii.« less

Pure moment testing for spinal biomechanics applications: Fixed versus sliding ring cable-driven test designs.

PubMed

Eguizabal, Johnny; Tufaga, Michael; Scheer, Justin K; Ames, Christopher; Lotz, Jeffrey C; Buckley, Jenni M

2010-05-07

In vitro multi-axial bending testing using pure moment loading conditions has become the standard in evaluating the effects of different types of surgical intervention on spinal kinematics. Simple, cable-driven experimental set-ups have been widely adopted because they require little infrastructure. Traditionally, "fixed ring" cable-driven experimental designs have been used; however, there have been concerns with the validity of this set-up in applying pure moment loading. This study involved directly comparing the loading state induced by a traditional "fixed ring" apparatus versus a novel "sliding ring" approach. Flexion-extension bending was performed on an artificial spine model and a single cadaveric test specimen, and the applied loading conditions to the specimen were measured with an in-line multiaxial load cell. The results showed that the fixed ring system applies flexion-extension moments that are 50-60% less than the intended values. This design also imposes non-trivial anterior-posterior shear forces, and non-uniform loading conditions were induced along the length of the specimen. The results of this study indicate that fixed ring systems have the potential to deviate from a pure moment loading state and that our novel sliding ring modification corrects this error in the original test design. This suggests that the proposed sliding ring design should be used for future in vitro spine biomechanics studies involving a cable-driven pure moment apparatus. Copyright 2010 Elsevier Ltd. All rights reserved.

Water Pump Development for the EVA PLSS

NASA Technical Reports Server (NTRS)

Schuller, Michael; Kurwitz, Cable; Goldman, Jeff; Morris, Kim; Trevino, Luis

2009-01-01

This paper describes the effort by the Texas Engineering Experiment Station (TEES) and Honeywell for NASA to design, fabricate, and test a preflight prototype pump for use in the Extravehicular activity (EVA) portable life support subsystem (PLSS). Major design decisions were driven by the need to reduce the pump s mass, power, and volume compared to the existing PLSS pump. In addition, the pump will accommodate a much wider range of abnormal conditions than the existing pump, including vapor/gas bubbles and increased pressure drop when employed to cool two suits simultaneously. A positive displacement, external gear type pump was selected because it offers the most compact and highest efficiency solution over the required range of flow rates and pressure drops. An additional benefit of selecting a gear pump design is that it is self priming and capable of ingesting noncondensable gas without becoming "air locked." The chosen pump design consists of a 28 V DC, brushless, sealless, permanent magnet motor driven, external gear pump that utilizes a Honeywell development that eliminates the need for magnetic coupling. Although the planned flight unit will use a sensorless motor with custom designed controller, the preflight prototype to be provided for this project incorporates Hall effect sensors, allowing an interface with a readily available commercial motor controller. This design approach reduced the cost of this project and gives NASA more flexibility in future PLSS laboratory testing. The pump design was based on existing Honeywell designs, but incorporated features specifically for the PLSS application, including all of the key features of the flight pump. Testing at TEES will simulate the vacuum environment in which the flight pump will operate. Testing will verify that the pump meets design requirements for range of flow rates, pressure rise, power consumption, working fluid temperature, operating time, and restart capability. Pump testing is currently scheduled for March, 2009, after which the pump will be delivered to NASA for further testing.

Portable wireless power transmission system for video capsule endoscopy.

PubMed

Zhiwei, Jia; Guozheng, Yan; Bingquan, Zhu

2014-10-01

Wireless power transmission is considered a practical way of overcoming the power shortage of wireless capsule endoscopy (VCE). However, most patients cannot tolerate the long hours of lying in a fixed transmitting coil during diagnosis. To develop a portable wireless power transmission system for VCE, a compact transmitting coil and a portable inverter circuit driven by rechargeable batteries are proposed. The couple coils, optimized considering the stability and safety conditions, are 28 turns of transmitting coil and six strands of receiving coil. The driven circuit is designed according to the portable principle. Experiments show that the integrated system could continuously supply power to a dual-head VCE for more than 8 h at a frame rate of 30 frames per second with resolution of 320 × 240. The portable VCE exhibits potential for clinical applications, but requires further improvement and tests.

Domain decomposition algorithms and computation fluid dynamics

NASA Technical Reports Server (NTRS)

Chan, Tony F.

1988-01-01

In the past several years, domain decomposition was a very popular topic, partly motivated by the potential of parallelization. While a large body of theory and algorithms were developed for model elliptic problems, they are only recently starting to be tested on realistic applications. The application of some of these methods to two model problems in computational fluid dynamics are investigated. Some examples are two dimensional convection-diffusion problems and the incompressible driven cavity flow problem. The construction and analysis of efficient preconditioners for the interface operator to be used in the iterative solution of the interface solution is described. For the convection-diffusion problems, the effect of the convection term and its discretization on the performance of some of the preconditioners is discussed. For the driven cavity problem, the effectiveness of a class of boundary probe preconditioners is discussed.

Preheating study by reflectivity measurements in laser-driven shocks

NASA Astrophysics Data System (ADS)

Benuzzi, A.; Koenig, M.; Faral, B.; Krishnan, J.; Pisani, F.; Batani, D.; Bossi, S.; Beretta, D.; Hall, T.; Ellwi, S.; Hüller, S.; Honrubia, J.; Grandjouan, N.

1998-06-01

A study on preheating effects in laser-driven shock waves is presented. Two different diagnostics were used: the color temperature measurement deduced by recording the target rear side emissivity in two spectral bands, and the rear surface reflectivity measurement by using a probe beam. In order to test the response of the two diagnostics to the preheating, three types of targets characterized by different radiative properties were used. The greater sensitivity of the second diagnostic compared with the first was demonstrated. A model which calculates the reflectivity using a one-dimensional hydrodynamic code data was developed. In this model, the wave propagation equations in the expanding plasma using an appropriate model for the electron-ion collision frequency applicable to the cold solid-hot plasma transition were solved. The comparison between the calculated and measured reflectivities allows us to estimate the preheating process.

Data-Driven Learning of Q-Matrix

PubMed Central

Liu, Jingchen; Xu, Gongjun; Ying, Zhiliang

2013-01-01

The recent surge of interests in cognitive assessment has led to developments of novel statistical models for diagnostic classification. Central to many such models is the well-known Q-matrix, which specifies the item–attribute relationships. This article proposes a data-driven approach to identification of the Q-matrix and estimation of related model parameters. A key ingredient is a flexible T-matrix that relates the Q-matrix to response patterns. The flexibility of the T-matrix allows the construction of a natural criterion function as well as a computationally amenable algorithm. Simulations results are presented to demonstrate usefulness and applicability of the proposed method. Extension to handling of the Q-matrix with partial information is presented. The proposed method also provides a platform on which important statistical issues, such as hypothesis testing and model selection, may be formally addressed. PMID:23926363

Control of Fine Particulate (PM2.5) Emissions from Restaurant Operations.

PubMed

Whynot, Jill; Quinn, Gary; Perryman, Pamela; Votlucka, Peter

1999-09-01

This paper describes efforts to reduce particulate matter (PM) emissions from restaurant operations, including application of an existing control method to a new equipment type. Commercial charbroiling in the South Coast Air Basin results in emissions of approximately 10 tons/day of fine particulate matter ( PM 2.5) and 1.3 tons/day of volatile organic compounds (VOCs). Over a seven-year period, the South Coast Air Quality Management District worked with industry to develop test methods for measuring emissions from various cooking operations, evaluate control technologies, and develop a rule to reduce these emissions. Of the two basic types of charbroilers-chain-driven and underfired-underfired produce four times the emissions when equivalent amounts of product are cooked. Cost-effective control technology is currently available only for chain-driven charbroilers. The application of flameless catalytic oxidizers to chain-driven charbroilers was found to effectively reduce emissions by at least 83% and is cost-effective. The catalysts have been used worldwide at restaurants for several years. Research efforts are underway to identify control options for underfired charbroilers. Implementation of Rule 1138, Control of Emissions from Restaurant Operations, adopted November 14, 1997, will result in reductions of 0.5 tons/day of PM 2.5 and 0.2 tons/day of VOCs. Future rules will result in reductions from underfired charbroilers and possibly other restaurant equipment when cost-effective solutions are available.

Control of fine particulate (PM2.5) emissions from restaurant operations.

PubMed

Whynot, J; Quinn, G; Perryman, P; Votlucka, P

1999-09-01

This paper describes efforts to reduce particulate matter (PM) emissions from restaurant operations, including application of an existing control method to a new equipment type. Commercial charbroiling in the South Coast Air Basin results in emissions of approximately 10 tons/day of fine particulate matter (PM2.5) and 1.3 tons/day of volatile organic compounds (VOCs). Over a seven-year period, the South Coast Air Quality Management District worked with industry to develop test methods for measuring emissions from various cooking operations, evaluate control technologies, and develop a rule to reduce these emissions. Of the two basic types of charbroilers--chain-driven and underfired--underfired produce four times the emissions when equivalent amounts of product are cooked. Cost-effective control technology is currently available only for chain-driven charbroilers. The application of flameless catalytic oxidizers to chain-driven charbroilers was found to effectively reduce emissions by at least 83% and is cost-effective. The catalysts have been used worldwide at restaurants for several years. Research efforts are underway to identify control options for underfired charbroilers. Implementation of Rule 1138, Control of Emissions from Restaurant Operations, adopted November 14, 1997, will result in reductions of 0.5 tons/day of PM2.5 and 0.2 tons/day of VOCs. Future rules will result in reductions from underfired charbroilers and possibly other restaurant equipment when cost-effective solutions are available.

Bond strength determination of hydroxyapatite coatings on Ti-6Al-4V substrates using the LAser Shock Adhesion Test (LASAT).

PubMed

Guipont, Vincent; Jeandin, Michel; Bansard, Sebastien; Khor, Khiam Aik; Nivard, Mariette; Berthe, Laurent; Cuq-Lelandais, Jean-Paul; Boustie, Michel

2010-12-15

An adhesion test procedure applied to plasma-sprayed hydroxyapatite (HA) coatings to measure the "LASAT threshold" (LAser Shock Adhesion test) is described. The good repeatability and minimal discrepancy of the laser-driven adhesion test data were ascertained for conventional plasma sprayed HA coatings. As a further demonstration, the procedure was applied to HA coatings with diverse characteristics on the ceramic/metal interface. Different preheating and grit blasting conditions and the presence of a thick plasma-sprayed Ti sublayer or a thin TiO(2) layer prepared by oxidation were investigated through LASAT. It was assessed that a rough surface can significantly improve the coating's bond strength. However, it was also demonstrated that a thin TiO(2) layer on a smooth Ti-6Al-4V substrate can have a major influence on adhesion as well. Preheating up to 270°C just prior to the first HA spraying pass had no effect on the adhesion strength. Further development of the procedure was done to achieve an in situ LASAT with in vitro conditions applied on HA coatings. To that end, different crystalline HA contents were soaked in simulated body fluid (SBF). Beyond the demonstration of the capability of this laser-driven adhesion test devoted to HA coatings in dry or liquid environment, the present study provided empirical information on pertinent processing characteristics that could strengthen or weaken the HA/Ti-6Al-4V bond. Copyright © 2010 Wiley Periodicals, Inc.

Materials, Manufacturing and Test Development of a Composite Fan Blade Leading Edge Subcomponent for Improved Impact Resistance

NASA Technical Reports Server (NTRS)

Handschuh, Katherine M.; Miller, Sandi G.; Sinnott, Matthew J.; Kohlman, Lee W.; Roberts, Gary D.; Pereira, J. Michael; Ruggeri, Charles R.

2014-01-01

Application of polymer matrix composite materials for jet engine fan blades is becoming attractive as an alternative to metallic blades; particularly for large engines where significant weight savings are recognized on moving to a composite structure. However, the weight benefit of the composite of is offset by a reduction of aerodynamic efficiency resulting from a necessary increase in blade thickness; relative to the titanium blades. Blade dimensions are largely driven by resistance to damage on bird strike. Further development of the composite material is necessary to allow composite blade designs to approximate the dimensions of a metallic fan blade. The reduction in thickness over the state of the art composite blades is expected to translate into structural weight reduction, improved aerodynamic efficiency, and therefore reduced fuel consumption. This paper presents test article design, subcomponent blade leading edge fabrication, test method development, and initial results from ballistic impact of a gelatin projectile on the leading edge of composite fan blades. The simplified test article geometry was developed to realistically simulate a blade leading edge while decreasing fabrication complexity. Impact data is presented on baseline composite blades and toughened blades; where a considerable improvement to impact resistance was recorded.

Materials, Manufacturing, and Test Development of a Composite Fan Blade Leading Edge Subcomponent for Improved Impact Resistance

NASA Technical Reports Server (NTRS)

Miller, Sandi G.; Handschuh, Katherine; Sinnott, Matthew J.; Kohlman, Lee W.; Roberts, Gary D.; Martin, Richard E.; Ruggeri, Charles R.; Pereira, J. Michael

2015-01-01

Application of polymer matrix composite materials for jet engine fan blades is becoming attractive as an alternative to metallic blades; particularly for large engines where significant weight savings are recognized on moving to a composite structure. However, the weight benefit of the composite is offset by a reduction of aerodynamic efficiency resulting from a necessary increase in blade thickness; relative to the titanium blades. Blade dimensions are largely driven by resistance to damage on bird strike. Further development of the composite material is necessary to allow composite blade designs to approximate the dimensions of a metallic fan blade. The reduction in thickness over the state of the art composite blades is expected to translate into structural weight reduction, improved aerodynamic efficiency, and therefore reduced fuel consumption. This paper presents test article design, subcomponent blade leading edge fabrication, test method development, and initial results from ballistic impact of a gelatin projectile on the leading edge of composite fan blades. The simplified test article geometry was developed to realistically simulate a blade leading edge while decreasing fabrication complexity. Impact data is presented on baseline composite blades and toughened blades; where a considerable improvement to impact resistance was recorded.

A mixed methods protocol for developing and testing implementation strategies for evidence-based obesity prevention in childcare: a cluster randomized hybrid type III trial.

PubMed

Swindle, Taren; Johnson, Susan L; Whiteside-Mansell, Leanne; Curran, Geoffrey M

2017-07-18

Despite the potential to reach at-risk children in childcare, there is a significant gap between current practices and evidence-based obesity prevention in this setting. There are few investigations of the impact of implementation strategies on the uptake of evidence-based practices (EBPs) for obesity prevention and nutrition promotion. This study protocol describes a three-phase approach to developing and testing implementation strategies to support uptake of EBPs for obesity prevention practices in childcare (i.e., key components of the WISE intervention). Informed by the i-PARIHS framework, we will use a stakeholder-driven evidence-based quality improvement (EBQI) process to apply information gathered in qualitative interviews on barriers and facilitators to practice to inform the design of implementation strategies. Then, a Hybrid Type III cluster randomized trial will compare a basic implementation strategy (i.e., intervention as usual) with an enhanced implementation strategy informed by stakeholders. All Head Start centers (N = 12) within one agency in an urban area in a southern state in the USA will be randomized to receive the basic or enhanced implementation with approximately 20 classrooms per group (40 educators, 400 children per group). The educators involved in the study, the data collectors, and the biostastician will be blinded to the study condition. The basic and enhanced implementation strategies will be compared on outcomes specified by the RE-AIM model (e.g., Reach to families, Effectiveness of impact on child diet and health indicators, Adoption commitment of agency, Implementation fidelity and acceptability, and Maintenance after 6 months). Principles of formative evaluation will be used throughout the hybrid trial. This study will test a stakeholder-driven approach to improve implementation, fidelity, and maintenance of EBPs for obesity prevention in childcare. Further, this study provides an example of a systematic process to develop and test a tailored, enhanced implementation strategy. ClinicalTrials.gov, NCT03075085.

Analysis and documentation of QCSEE (Quiet Clean Short-haul Experimental Engine) over-the-wing exhaust system development

NASA Technical Reports Server (NTRS)

Ammer, R. C.; Kutney, J. T.

1977-01-01

A static scale model test program was conducted in the static test area of the NASA-Langley 9.14- by 18.29 m(30- by 60-ft) Full-Scale Wind Tunnel Facility to develop an over-the-wing (OTW) nozzle and reverser configuration for the Quiet Clean Short-Haul Experimental Engine (QCSEE). Three nozzles and one basic reverser configuration were tested over the QCSEE takeoff and approach power nozzle pressure ratio range between 1.1 and 1.3. The models were scaled to 8.53% of QCSEE engine size and tested behind two 13.97-cm (5.5-in.) diameter tip-turbine-driven fan simulators coupled in tandem. An OTW nozzle and reverser configuration was identified which satisfies the QCSEE experimental engine requirements in terms of nozzle cycle area variation capability and reverse thrust level, and provides good jet flow spreading over a wing upper surface for achievement of high propulsive lift performance.

Data-driven approach for assessing utility of medical tests using electronic medical records.

PubMed

Skrøvseth, Stein Olav; Augestad, Knut Magne; Ebadollahi, Shahram

2015-02-01

To precisely define the utility of tests in a clinical pathway through data-driven analysis of the electronic medical record (EMR). The information content was defined in terms of the entropy of the expected value of the test related to a given outcome. A kernel density classifier was used to estimate the necessary distributions. To validate the method, we used data from the EMR of the gastrointestinal department at a university hospital. Blood tests from patients undergoing surgery for gastrointestinal surgery were analyzed with respect to second surgery within 30 days of the index surgery. The information content is clearly reflected in the patient pathway for certain combinations of tests and outcomes. C-reactive protein tests coupled to anastomosis leakage, a severe complication show a clear pattern of information gain through the patient trajectory, where the greatest gain from the test is 3-4 days post index surgery. We have defined the information content in a data-driven and information theoretic way such that the utility of a test can be precisely defined. The results reflect clinical knowledge. In the case we used the tests carry little negative impact. The general approach can be expanded to cases that carry a substantial negative impact, such as in certain radiological techniques. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

Stakeholder-Driven Quality Improvement: A Compelling Force for Clinical Practice Guidelines.

PubMed

Rosenfeld, Richard M; Wyer, Peter C

2018-01-01

Clinical practice guideline development should be driven by rigorous methodology, but what is less clear is where quality improvement enters the process: should it be a priority-guiding force, or should it enter only after recommendations are formulated? We argue for a stakeholder-driven approach to guideline development, with an overriding goal of quality improvement based on stakeholder perceptions of needs, uncertainties, and knowledge gaps. In contrast, the widely used topic-driven approach, which often makes recommendations based only on randomized controlled trials, is driven by epidemiologic purity and evidence rigor, with quality improvement a downstream consideration. The advantages of a stakeholder-driven versus a topic-driven approach are highlighted by comparisons of guidelines for otitis media with effusion, thyroid nodules, sepsis, and acute bacterial rhinosinusitis. These comparisons show that stakeholder-driven guidelines are more likely to address the quality improvement needs and pressing concerns of clinicians and patients, including understudied populations and patients with multiple chronic conditions. Conversely, a topic-driven approach often addresses "typical" patients, based on research that may not reflect the needs of high-risk groups excluded from studies because of ethical issues or a desire for purity of research design.

Evaluation of lightning accommodation systems for wind-driven turbine rotors

NASA Technical Reports Server (NTRS)

Bankaitis, H.

1982-01-01

Wind-driven turbine generators are being evaluated as an alternative source of electric energy. Areas of favorable location for the wind-driven turbines (high wind density) coincide with areas of high incidence of thunderstorm activity. These locations, coupled with the 30-m or larger diameter rotor blades, make the wind-driven turbine blades probable terminations for lightning strikes. Several candidate systems of lightning accommodation for composite-structural-material blades were designed and their effectiveness evaluated by submitting the systems to simulated lightning strikes. The test data were analyzed and system design were reviewed on the basis of the analysis.

International STakeholder NETwork (ISTNET): Creating a ...

EPA Pesticide Factsheets

A major problem in developmental neurotoxicity (DNT) risk assessment is the lack of toxicological hazard information for most compounds. Therefore, new approaches are being considered to provide adequate experimental data that allow regulatory decisions. This process requires a matching of regulatory needs on the one hand and the opportunities provided by new test sys-tems and methods on the other hand. Alignment of academically and industrially-driven assay development with regulatory needs in the field of DNT is a core mission of the International STakeholder NETwork (ISNET) in DNT testing. The first meeting of ISTNET was held in Zur-ich on 23-24 January 2014 in order to explore the concept of adverse outcome pathway (AOP) to practical DNT testing. AOPs were considered promising tools to promote test systems develop-ment according to regulatory needs. Moreover, the AOP concept was identified as an important guiding principle to assemble predictive integrated testing strategies (ITSs) for DNT. The recommendations on a roadmap towards AOP-based DNT testing is considered a stepwise approach, operating initially with incomplete AOPs for compound grouping, and focussing on key events of neurodevelopment. Next steps to be considered in follow-up activities are the use of case studies to further apply the AOP concept in regulatory DNT testing, making use of AOP intersections (common key events) for economic development of screening assays, and address-ing the transit

The application of domain-driven design in NMS

NASA Astrophysics Data System (ADS)

Zhang, Jinsong; Chen, Yan; Qin, Shengjun

2011-12-01

In the traditional design approach of data-model-driven, system analysis and design phases are often separated which makes the demand information can not be expressed explicitly. The method is also easy to lead developer to the process-oriented programming, making codes between the modules or between hierarchies disordered. So it is hard to meet requirement of system scalability. The paper proposes a software hiberarchy based on rich domain model according to domain-driven design named FHRDM, then the Webwork + Spring + Hibernate (WSH) framework is determined. Domain-driven design aims to construct a domain model which not only meets the demand of the field where the software exists but also meets the need of software development. In this way, problems in Navigational Maritime System (NMS) development like big system business volumes, difficulty of requirement elicitation, high development costs and long development cycle can be resolved successfully.

ODISEES Data Portal Announcement

Atmospheric Science Data Center

2015-11-13

... larger image The Ontology-Driven Interactive Search Environment for Earth Science, developed at the Atmospheric Science Data Center ... The Ontology-Driven Interactive Search Environment for Earth Science, developed at the Atmospheric Science Data Center ...

Improvement of driven pile installation and design in Illinois : phase 2.

DOT National Transportation Integrated Search

2014-09-01

A dynamic load test program consisting of 38 sites and 111 piles with restrikes was conducted throughout Illinois : to improve the Illinois Department of Transportation design of driven piling. Pile types included steel H-piles and : closed-ended pip...

Predictive Service Life Tests for Roofing Membranes

NASA Astrophysics Data System (ADS)

Bailey, David M.; Cash, Carl G.; Davies, Arthur G.

2002-09-01

The average service life of roofing membranes used in low-slope applications on U.S. Army buildings is estimated to be considerably shorter than the industry-presumed 20-year design life, even when installers carefully adhere to the latest guide specifications. This problem is due in large part to market-driven product development cycles, which do not include time for long-term field testing. To reduce delivery costs, contractors may provide untested, interior membranes in place of ones proven satisfactory in long-term service. Federal procurement regulations require that roofing systems and components be selected according to desired properties and generic type, not brand name. The problem is that a material certified to have satisfactory properties at installation time will not necessarily retain those properties in service. The overall objective of this research is to develop a testing program that can be executed in a matter of weeks to adequately predict a membrane's long-term performance in service. This report details accelerated aging tests of 12 popular membrane materials in the laboratory, and describes outdoor experiment stations set up for long-term exposure tests of those same membranes. The laboratory results will later be correlated with the outdoor test results to develop performance models and predictive service life tests.

Global Response to Local Ionospheric Mass Ejection

NASA Technical Reports Server (NTRS)

Moore, T. E.; Fok, M.-C.; Delcourt, D. C.; Slinker, S. P.; Fedder, J. A.

2010-01-01

We revisit a reported "Ionospheric Mass Ejection" using prior event observations to guide a global simulation of local ionospheric outflows, global magnetospheric circulation, and plasma sheet pressurization, and comparing our results with the observed global response. Our simulation framework is based on test particle motions in the Lyon-Fedder-Mobarry (LFM) global circulation model electromagnetic fields. The inner magnetosphere is simulated with the Comprehensive Ring Current Model (CRCM) of Fok and Wolf, driven by the transpolar potential developed by the LFM magnetosphere, and includes an embedded plasmaspheric simulation. Global circulation is stimulated using the observed solar wind conditions for the period 24-25 Sept 1998. This period begins with the arrival of a Coronal Mass Ejection, initially with northward, but later with southward interplanetary magnetic field. Test particles are launched from the ionosphere with fluxes specified by local empirical relationships of outflow to electrodynamic and particle precipitation imposed by the MIlD simulation. Particles are tracked until they are lost from the system downstream or into the atmosphere, using the full equations of motion. Results are compared with the observed ring current and a simulation of polar and auroral wind outflows driven globally by solar wind dynamic pressure. We find good quantitative agreement with the observed ring current, and reasonable qualitative agreement with earlier simulation results, suggesting that the solar wind driven global simulation generates realistic energy dissipation in the ionosphere and that the Strangeway relations provide a realistic local outflow description.

Design and performance analysis of a rotary traveling wave ultrasonic motor with double vibrators.

PubMed

Dong, Zhaopeng; Yang, Ming; Chen, Zhangqi; Xu, Liang; Meng, Fan; Ou, Wenchu

2016-09-01

This paper presents the development of a rotary traveling wave ultrasonic motor, in which a vibrating stator and vibrating rotor are combined in one motor. The stator and rotor are designed as similar structures an elastic body and a piezoelectric ceramic ring. In exciting of the piezoelectric ceramics, the elastic body of the stator and rotor will generate respective traveling waves, which force each other forward in the contact zone. Based on the elliptical rule of particle motion and matching principle of vibration, the design rules of two vibrators are determined. The finite element method is used to design the sizes of vibrators to ensure that they operate in resonance, and the simulation is verified by measuring the vibration with an impedance analyzer. It is found out that to maintain an appropriate contact between the stator and rotor, two vibrators need to be designed with close resonance frequencies, different vibration amplitudes, and be driven by an identical driving frequency. To analyze this innovative contact mechanism, particle velocity synthesis theory and contact force analysis using Hertz contact model are carried out. Finally, a prototype is fabricated and tested to verify the theoretical results. The test results show that the output performance of the motor driven by the two vibrators is significantly improved compared to the motor driven by a sole stator or rotor, which confirms the validity of the double-vibrator motor concept. Copyright © 2016 Elsevier B.V. All rights reserved.

An analytically solvable three-body break-up model problem in hyperspherical coordinates

NASA Astrophysics Data System (ADS)

Ancarani, L. U.; Gasaneo, G.; Mitnik, D. M.

2012-10-01

An analytically solvable S-wave model for three particles break-up processes is presented. The scattering process is represented by a non-homogeneous Coulombic Schrödinger equation where the driven term is given by a Coulomb-like interaction multiplied by the product of a continuum wave function and a bound state in the particles coordinates. The closed form solution is derived in hyperspherical coordinates leading to an analytic expression for the associated scattering transition amplitude. The proposed scattering model contains most of the difficulties encountered in real three-body scattering problem, e.g., non-separability in the electrons' spherical coordinates and Coulombic asymptotic behavior. Since the coordinates' coupling is completely different, the model provides an alternative test to that given by the Temkin-Poet model. The knowledge of the analytic solution provides an interesting benchmark to test numerical methods dealing with the double continuum, in particular in the asymptotic regions. An hyperspherical Sturmian approach recently developed for three-body collisional problems is used to reproduce to high accuracy the analytical results. In addition to this, we generalized the model generating an approximate wave function possessing the correct radial asymptotic behavior corresponding to an S-wave three-body Coulomb problem. The model allows us to explore the typical structure of the solution of a three-body driven equation, to identify three regions (the driven, the Coulombic and the asymptotic), and to analyze how far one has to go to extract the transition amplitude.

AC motor and generator requirements for isolated WECS

NASA Technical Reports Server (NTRS)

Park, G. L.; Mccleer, P. J.; Hanson, B.; Weinberg, B.; Krauss, O.

1985-01-01

After surveying electrically driven loads used on productive farms, the investigators chose three pumps for testing at voltages and frequencies far outside the normal operating range. These loads extract and circulate water and move heat via air, and all are critical to farm productivity. The object was to determine the envelope of supply voltage and frequency over which these loads would operate stably for time intervals under 1 hour. This information is among that needed to determine the feasibility of supplying critical loads, in case of a utility outage, from a wind driven alternator whose output voltage and frequency will vary dramatically in most continental wind regimes. Other related work is surveyed. The salient features and limitations of the test configurations used and the data reduction are described. The development of simulation models suitable for a small computer are outlined. The results are primarily displayed on the voltage frequency plane with the general conclusion that the particular pump models considered will operate over the range of 50 to 90 Hz and a voltage band which starts below rated, decreases as frequency decreases, and is limited on the high side by excessive motor heating. For example, centrifugal pump operating voltage ranges as extensive .4 to 1.4 appear possible. Particular problems with starting, stalling due to lack of motor torque, high speed cavitation, and likely overheating are addressed in a listing of required properties for wind driven alternators and their controllers needed for use in the isolated or stand alone configuration considered.

Does the transition to an active-learning environment for the introductory course reduce students' overall knowledge of the various disciplines in biology?

PubMed

Simurda, Maryanne C

2012-01-01

As biology education is being redesigned toward an interdisciplinary focus and as pedagogical trends move toward active-learning strategies and investigative experiences, a restructuring of the course content for the Introductory Biology course is necessary. The introductory course in biology has typically been a survey of all the biosciences. If the total number of topics covered is reduced, is the students' overall knowledge of biology also reduced? Our introductory course has been substantially modified away from surveying the biological sciences and toward providing a deep understanding of a particular biological topic, as well as focusing on developing students' analytical and communication skills. Because of this shift to a topic-driven approach for the introductory course, we were interested in assessing our graduating students' overall knowledge of the various biological disciplines. Using the Major Field Test - Biology (Educational Testing Service (ETS), Princeton, NJ), we compared the test performance of graduating students who had a traditional lecture-based introductory course to those who had a topic-driven active-learning introductory course. Our results suggest that eliminating the traditional survey of biology and, instead, focusing on quantitative and writing skills at the introductory level do not affect our graduating students' overall breadth of knowledge of the various biosciences.

[Engine-driven preparation of curved root canals: a platform to assess physical parameters].

PubMed

Peters, O A; Kappeler, S; Bucher, W; Barbakow, F

2001-01-01

The number of engine-driven rotary instruments available on the market is steadily increasing. These instruments enable clinicians to prepare better shaped root canals, however, rotary instruments have a higher risk for fracture than hand instruments. Unfortunately, the stresses placed on engine-driven rotary instruments in curved canals are insufficiently studied. The aim of this study was to develop a device which could measure more accurately the physical parameters influencing rotary instruments in curved canals. For this purpose, a specially designed machine was constructed to measure the torque which develops between the rotary instrument and the motor. Apical forces and penetration depths could also be directly measured in real time. A variety of other measurements was also possible because of other special set-ups integrated into the device. In the current study torque was assessed for GT-Files, size 35 with a .12 and sizes 20 with a .12 to .06 taper. In additions to preparations in simulated canals in plastic blocks, the "ISO 3630-1 specification for fracture moment" and "number of cycles till fatigue fracture" was measured. The findings indicated that when instruments were used for preparations, torques up to 40 Nmm were present. This exceeded the static fracture load, which was less than than 13 Nmm for the size 20 with .12 taper. In contrast, the number of rotations were more than 10 times lower when shaping canals in plastic blocks with a 5 mm radius of curvature than the number of rotations to fracture in the "cyclic fatigue test". This suggests that a GT-instrument could be used in ten canals. The apical force was always greater than 1 N and occasionally, 8 N or more was recorded. Further studies on natural teeth with varying canal geometries are required using the specially developed torsional machine to reduce the incidence of instrument fracture. In this way an efficient clinical potential can be confirmed for engine-driven rotary instruments in canal preparation.

Development strategies for the satellite flight software on-board Meteosat Third Generation

NASA Astrophysics Data System (ADS)

Tipaldi, Massimo; Legendre, Cedric; Koopmann, Olliver; Ferraguto, Massimo; Wenker, Ralf; D'Angelo, Gianni

2018-04-01

Nowadays, satellites are becoming increasingly software dependent. Satellite Flight Software (FSW), that is to say, the application software running on the satellite main On-Board Computer (OBC), plays a relevant role in implementing complex space mission requirements. In this paper, we examine relevant technical approaches and programmatic strategies adopted for the development of the Meteosat Third Generation Satellite (MTG) FSW. To begin with, we present its layered model-based architecture, and the means for ensuring a robust and reliable interaction among the FSW components. Then, we focus on the selection of an effective software development life cycle model. In particular, by combining plan-driven and agile approaches, we can fulfill the need of having preliminary SW versions. They can be used for the elicitation of complex system-level requirements as well as for the initial satellite integration and testing activities. Another important aspect can be identified in the testing activities. Indeed, very demanding quality requirements have to be fulfilled in satellite SW applications. This manuscript proposes a test automation framework, which uses an XML-based test procedure language independent of the underlying test environment. Finally, a short overview of the MTG FSW sizing and timing budgets concludes the paper.

Integrated Structural Analysis and Test Program

NASA Technical Reports Server (NTRS)

Kaufman, Daniel

2005-01-01

An integrated structural-analysis and structure-testing computer program is being developed in order to: Automate repetitive processes in testing and analysis; Accelerate pre-test analysis; Accelerate reporting of tests; Facilitate planning of tests; Improve execution of tests; Create a vibration, acoustics, and shock test database; and Integrate analysis and test data. The software package includes modules pertaining to sinusoidal and random vibration, shock and time replication, acoustics, base-driven modal survey, and mass properties and static/dynamic balance. The program is commanded by use of ActiveX controls. There is minimal need to generate command lines. Analysis or test files are selected by opening a Windows Explorer display. After selecting the desired input file, the program goes to a so-called analysis data process or test data process, depending on the type of input data. The status of the process is given by a Windows status bar, and when processing is complete, the data are reported in graphical, tubular, and matrix form.

Genetics-based methods for detection of Salmonella spp. in foods.

PubMed

Mozola, Mark A

2006-01-01

Genetic methods are now at the forefront of foodborne pathogen testing. The sensitivity, specificity, and inclusivity advantages offered by deoxyribonucleic acid (DNA) probe technology have driven an intense effort in methods development over the past 20 years. DNA probe-based methods for Salmonella spp. and other pathogens have progressed from time-consuming procedures involving the use of radioisotopes to simple, high throughput, automated assays. The analytical sensitivity of nucleic acid amplification technology has facilitated a reduction in analysis time by allowing enriched samples to be tested for previously undetectable quantities of analyte. This article will trace the evolution of the development of genetic methods for detection of Salmonella in foods, review the basic assay formats and their advantages and limitations, and discuss method performance characteristics and considerations for selection of methods.

Seals Flow Code Development 1993

NASA Technical Reports Server (NTRS)

Liang, Anita D. (Compiler); Hendricks, Robert C. (Compiler)

1994-01-01

Seals Workshop of 1993 code releases include SPIRALI for spiral grooved cylindrical and face seal configurations; IFACE for face seals with pockets, steps, tapers, turbulence, and cavitation; GFACE for gas face seals with 'lift pad' configurations; and SCISEAL, a CFD code for research and design of seals of cylindrical configuration. GUI (graphical user interface) and code usage was discussed with hands on usage of the codes, discussions, comparisons, and industry feedback. Other highlights for the Seals Workshop-93 include environmental and customer driven seal requirements; 'what's coming'; and brush seal developments including flow visualization, numerical analysis, bench testing, T-700 engine testing, tribological pairing and ceramic configurations, and cryogenic and hot gas facility brush seal results. Also discussed are seals for hypersonic engines and dynamic results for spiral groove and smooth annular seals.

Electrically Driven Thermal Management: Flight Validation, Experiment Development, Future Technologies

NASA Technical Reports Server (NTRS)

Didion, Jeffrey R.

2018-01-01

Electrically Driven Thermal Management is an active research and technology development initiative incorporating ISS technology flight demonstrations (STP-H5), development of Microgravity Science Glovebox (MSG) flight experiment, and laboratory-based investigations of electrically based thermal management techniques. The program targets integrated thermal management for future generations of RF electronics and power electronic devices. This presentation reviews four program elements: i.) results from the Electrohydrodynamic (EHD) Long Term Flight Demonstration launched in February 2017 ii.) development of the Electrically Driven Liquid Film Boiling Experiment iii.) two University based research efforts iv.) development of Oscillating Heat Pipe evaluation at Goddard Space Flight Center.

A Single-Session Preliminary Evaluation of an Affordable BCI-Controlled Arm Exoskeleton and Motor-Proprioception Platform.

PubMed

Elnady, Ahmed Mohamed; Zhang, Xin; Xiao, Zhen Gang; Yong, Xinyi; Randhawa, Bubblepreet Kaur; Boyd, Lara; Menon, Carlo

2015-01-01

Traditional, hospital-based stroke rehabilitation can be labor-intensive and expensive. Furthermore, outcomes from rehabilitation are inconsistent across individuals and recovery is hard to predict. Given these uncertainties, numerous technological approaches have been tested in an effort to improve rehabilitation outcomes and reduce the cost of stroke rehabilitation. These techniques include brain-computer interface (BCI), robotic exoskeletons, functional electrical stimulation (FES), and proprioceptive feedback. However, to the best of our knowledge, no studies have combined all these approaches into a rehabilitation platform that facilitates goal-directed motor movements. Therefore, in this paper, we combined all these technologies to test the feasibility of using a BCI-driven exoskeleton with FES (robotic training device) to facilitate motor task completion among individuals with stroke. The robotic training device operated to assist a pre-defined goal-directed motor task. Because it is hard to predict who can utilize this type of technology, we considered whether the ability to adapt skilled movements with proprioceptive feedback would predict who could learn to control a BCI-driven robotic device. To accomplish this aim, we developed a motor task that requires proprioception for completion to assess motor-proprioception ability. Next, we tested the feasibility of robotic training system in individuals with chronic stroke (n = 9) and found that the training device was well tolerated by all the participants. Ability on the motor-proprioception task did not predict the time to completion of the BCI-driven task. Both participants who could accurately target (n = 6) and those who could not (n = 3), were able to learn to control the BCI device, with each BCI trial lasting on average 2.47 min. Our results showed that the participants' ability to use proprioception to control motor output did not affect their ability to use the BCI-driven exoskeleton with FES. Based on our preliminary results, we show that our robotic training device has potential for use as therapy for a broad range of individuals with stroke.

A Single-Session Preliminary Evaluation of an Affordable BCI-Controlled Arm Exoskeleton and Motor-Proprioception Platform

PubMed Central

Elnady, Ahmed Mohamed; Zhang, Xin; Xiao, Zhen Gang; Yong, Xinyi; Randhawa, Bubblepreet Kaur; Boyd, Lara; Menon, Carlo

2015-01-01

Traditional, hospital-based stroke rehabilitation can be labor-intensive and expensive. Furthermore, outcomes from rehabilitation are inconsistent across individuals and recovery is hard to predict. Given these uncertainties, numerous technological approaches have been tested in an effort to improve rehabilitation outcomes and reduce the cost of stroke rehabilitation. These techniques include brain–computer interface (BCI), robotic exoskeletons, functional electrical stimulation (FES), and proprioceptive feedback. However, to the best of our knowledge, no studies have combined all these approaches into a rehabilitation platform that facilitates goal-directed motor movements. Therefore, in this paper, we combined all these technologies to test the feasibility of using a BCI-driven exoskeleton with FES (robotic training device) to facilitate motor task completion among individuals with stroke. The robotic training device operated to assist a pre-defined goal-directed motor task. Because it is hard to predict who can utilize this type of technology, we considered whether the ability to adapt skilled movements with proprioceptive feedback would predict who could learn to control a BCI-driven robotic device. To accomplish this aim, we developed a motor task that requires proprioception for completion to assess motor-proprioception ability. Next, we tested the feasibility of robotic training system in individuals with chronic stroke (n = 9) and found that the training device was well tolerated by all the participants. Ability on the motor-proprioception task did not predict the time to completion of the BCI-driven task. Both participants who could accurately target (n = 6) and those who could not (n = 3), were able to learn to control the BCI device, with each BCI trial lasting on average 2.47 min. Our results showed that the participants’ ability to use proprioception to control motor output did not affect their ability to use the BCI-driven exoskeleton with FES. Based on our preliminary results, we show that our robotic training device has potential for use as therapy for a broad range of individuals with stroke. PMID:25870554

A General and Efficient Method for Incorporating Precise Spike Times in Globally Time-Driven Simulations

PubMed Central

Hanuschkin, Alexander; Kunkel, Susanne; Helias, Moritz; Morrison, Abigail; Diesmann, Markus

2010-01-01

Traditionally, event-driven simulations have been limited to the very restricted class of neuronal models for which the timing of future spikes can be expressed in closed form. Recently, the class of models that is amenable to event-driven simulation has been extended by the development of techniques to accurately calculate firing times for some integrate-and-fire neuron models that do not enable the prediction of future spikes in closed form. The motivation of this development is the general perception that time-driven simulations are imprecise. Here, we demonstrate that a globally time-driven scheme can calculate firing times that cannot be discriminated from those calculated by an event-driven implementation of the same model; moreover, the time-driven scheme incurs lower computational costs. The key insight is that time-driven methods are based on identifying a threshold crossing in the recent past, which can be implemented by a much simpler algorithm than the techniques for predicting future threshold crossings that are necessary for event-driven approaches. As run time is dominated by the cost of the operations performed at each incoming spike, which includes spike prediction in the case of event-driven simulation and retrospective detection in the case of time-driven simulation, the simple time-driven algorithm outperforms the event-driven approaches. Additionally, our method is generally applicable to all commonly used integrate-and-fire neuronal models; we show that a non-linear model employing a standard adaptive solver can reproduce a reference spike train with a high degree of precision. PMID:21031031

Lightweight approach to model traceability in a CASE tool

NASA Astrophysics Data System (ADS)

Vileiniskis, Tomas; Skersys, Tomas; Pavalkis, Saulius; Butleris, Rimantas; Butkiene, Rita

2017-07-01

A term "model-driven" is not at all a new buzzword within the ranks of system development community. Nevertheless, the ever increasing complexity of model-driven approaches keeps fueling all kinds of discussions around this paradigm and pushes researchers forward to research and develop new and more effective ways to system development. With the increasing complexity, model traceability, and model management as a whole, becomes indispensable activities of model-driven system development process. The main goal of this paper is to present a conceptual design and implementation of a practical lightweight approach to model traceability in a CASE tool.

Potential of biogenic hydrogen production for hydrogen driven remediation strategies in marine environments.

PubMed

Hosseinkhani, Baharak; Hennebel, Tom; Boon, Nico

2014-09-25

Fermentative production of bio-hydrogen (bio-H2) from organic residues has emerged as a promising alternative for providing the required electron source for hydrogen driven remediation strategies. Unlike the widely used production of H2 by bacteria in fresh water systems, few reports are available regarding the generation of biogenic H2 and optimisation processes in marine systems. The present research aims to optimise the capability of an indigenous marine bacterium for the production of bio-H2 in marine environments and subsequently develop this process for hydrogen driven remediation strategies. Fermentative conversion of organics in marine media to H2 using a marine isolate, Pseudoalteromonas sp. BH11, was determined. A Taguchi design of experimental methodology was employed to evaluate the optimal nutritional composition in batch tests to improve bio-H2 yields. Further optimisation experiments showed that alginate-immobilised bacterial cells were able to produce bio-H2 at the same rate as suspended cells over a period of several weeks. Finally, bio-H2 was used as electron donor to successfully dehalogenate trichloroethylene (TCE) using biogenic palladium nanoparticles as a catalyst. Fermentative production of bio-H2 can be a promising technique for concomitant generation of an electron source for hydrogen driven remediation strategies and treatment of organic residue in marine ecosystems. Copyright © 2014 Elsevier B.V. All rights reserved.

Microwave Power for Smart Membrane Actuators

NASA Technical Reports Server (NTRS)

Choi, Sang H.; Song, Kyo D.; Golembiewski, Walter T.; Chu, Sang-Hyon; King, Glen C.

2002-01-01

The concept of microwave-driven smart membrane actuators is envisioned as the best option to alleviate the complexity associated with hard-wired control circuitry. A large, ultra-light space structure, such as solar sails and Gossamer spacecrafts, requires a distribution of power into individual membrane actuators to control them in an effective way. A patch rectenna array with a high voltage output was developed to drive smart membrane actuators. Networked patch rectenna array receives and converts microwave power into a DC power for an array of smart actuators. To use microwave power effectively, the concept of a power allocation and distribution (PAD) circuit is developed and tested for networking a rectenna/actuator patch array. For the future development, the PAD circuit could be imbedded into a single embodiment of rectenna and actuator array with the thin-film microcircuit embodiment. Preliminary design and fabrication of PAD circuitry that consists of a sixteen nodal elements were made for laboratory testing.

SLM Produced Hermetically Sealed Isolation Valve

NASA Technical Reports Server (NTRS)

Richard, James

2014-01-01

Marshall Space Flight Center (MSFC) has developed a valve concept to replace traditional pyrotechnic-driven isolation valves. This paper will describe the valve design and development process. The valve design uses a stem/wedge to support a disk inside the valve. That disk hermetically seals the pressurized fluids. A release mechanism holds the stem/wedge and a large spring in place. When required to open, a solenoid is energized and pulls the release mechanism allowing the spring to pull the stem/wedge away from the disk. Now the disk is unsupported and the pressure ruptures the disk allowing flow to the outlet of the valve. This paper will provide details of this design, describe the development testing, and show the results from the valve level tests performed. Also, a trade study is presented to show the advantages of this design to a conventional pyrotechnic-based valve.

SLM Produced Hermetically Sealed Isolation Valve

NASA Technical Reports Server (NTRS)

Richard, James A.

2014-01-01

Marshall Space Flight Center (MSFC) has developed a valve concept to replace traditional pyrotechnic driven isolation valves. This paper will describe the valve design and development process. The valve design uses a stem/wedge to support a disk inside the valve. That disk hermetically seals the pressurized fluids. A release mechanism holds the stem/wedge and a large spring in place. When required to open, a solenoid is energized and pulls the release mechanism allowing the spring to pull the stem/wedge away from the disk. Now the disk is unsupported and the pressure ruptures the disk allowing flow to the outlet of the valve. This paper will provide details of this design, describe the development testing, and show the results from the valve level tests performed. Also, a trade study is presented to show the advantages of this design to a conventional pyrotechnic based valve.

The Martian climate: Energy balance models with CO2/H2O atmospheres

NASA Technical Reports Server (NTRS)

Hoffert, M. I.

1984-01-01

Progress in the development of a multi-reservoir, time dependent energy balance climate model for Mars driven by prescribed insolation at the top of the atmosphere is reported. The first approximately half-year of the program was devoted to assembling and testing components of the full model. Specific accomplishments were made on a longwave radiation code, coupling seasonal solar input to a ground temperature simulation, and conceptualizing an approach to modeling the seasonal pressure waves that develop in the Martian atmosphere as a result of sublimation and condensation of CO2 in polar regions.

Evaluation of a Kinematically-Driven Finite Element Footstrike Model.

PubMed

Hannah, Iain; Harland, Andy; Price, Dan; Schlarb, Heiko; Lucas, Tim

2016-06-01

A dynamic finite element model of a shod running footstrike was developed and driven with 6 degree of freedom foot segment kinematics determined from a motion capture running trial. Quadratic tetrahedral elements were used to mesh the footwear components with material models determined from appropriate mechanical tests. Model outputs were compared with experimental high-speed video (HSV) footage, vertical ground reaction force (GRF), and center of pressure (COP) excursion to determine whether such an approach is appropriate for the development of athletic footwear. Although unquantified, good visual agreement to the HSV footage was observed but significant discrepancies were found between the model and experimental GRF and COP readings (9% and 61% of model readings outside of the mean experimental reading ± 2 standard deviations, respectively). Model output was also found to be highly sensitive to input kinematics with a 120% increase in maximum GRF observed when translating the force platform 2 mm vertically. While representing an alternative approach to existing dynamic finite element footstrike models, loading highly representative of an experimental trial was not found to be achievable when employing exclusively kinematic boundary conditions. This significantly limits the usefulness of employing such an approach in the footwear development process.

The role of endogenous and exogenous mechanisms in the formation of R&D networks

NASA Astrophysics Data System (ADS)

Tomasello, Mario V.; Perra, Nicola; Tessone, Claudio J.; Karsai, Márton; Schweitzer, Frank

2014-07-01

We develop an agent-based model of strategic link formation in Research and Development (R&D) networks. Empirical evidence has shown that the growth of these networks is driven by mechanisms which are both endogenous to the system (that is, depending on existing alliances patterns) and exogenous (that is, driven by an exploratory search for newcomer firms). Extant research to date has not investigated both mechanisms simultaneously in a comparative manner. To overcome this limitation, we develop a general modeling framework to shed light on the relative importance of these two mechanisms. We test our model against a comprehensive dataset, listing cross-country and cross-sectoral R&D alliances from 1984 to 2009. Our results show that by fitting only three macroscopic properties of the network topology, this framework is able to reproduce a number of micro-level measures, including the distributions of degree, local clustering, path length and component size, and the emergence of network clusters. Furthermore, by estimating the link probabilities towards newcomers and established firms from the data, we find that endogenous mechanisms are predominant over the exogenous ones in the network formation, thus quantifying the importance of existing structures in selecting partner firms.

Coordination control of flexible manufacturing systems

NASA Astrophysics Data System (ADS)

Menon, Satheesh R.

One of the first attempts was made to develop a model driven system for coordination control of Flexible Manufacturing Systems (FMS). The structure and activities of the FMS are modeled using a colored Petri Net based system. This approach has the advantage of being able to model the concurrency inherent in the system. It provides a method for encoding the system state, state transitions and the feasible transitions at any given state. Further structural analysis (for detecting conflicting actions, deadlocks which might occur during operation, etc.) can be performed. The problem is also addressed of implementing and testing the behavior of existing dynamic scheduling approaches in simulations of realistic situations. A simulation architecture was proposed and performance evaluation was carried out for establishing the correctness of the model, stability of the system from a structural (deadlocks) and temporal (boundedness of backlogs) points of view, and for collection of statistics for performance measures such as machine and robot utilizations, average wait times and idle times of resources. A real-time implementation architecture for the coordination controller was also developed and implemented in a software simulated environment. Given the current technology of FMS control, the model-driven colored Petri net-based approach promises to develop a very flexible control environment.

Effects of electromyography-driven robot-aided hand training with neuromuscular electrical stimulation on hand control performance after chronic stroke.

PubMed

Rong, Wei; Tong, Kai Yu; Hu, Xiao Ling; Ho, Sze Kit

2015-03-01

An electromyography-driven robot system integrated with neuromuscular electrical stimulation (NMES) was developed to investigate its effectiveness on post-stroke rehabilitation. The performance of this system in assisting finger flexion/extension with different assistance combinations was evaluated in five stroke subjects. Then, a pilot study with 20-sessions training was conducted to evaluate the training's effectiveness. The results showed that combined assistance from the NMES-robot could improve finger movement accuracy, encourage muscle activation of the finger muscles and suppress excessive muscular activities in the elbow joint. When assistances from both NMES and the robot were 50% of their maximum assistances, finger-tracking performance had the best results, with the lowest root mean square error, greater range of motion, higher voluntary muscle activations of the finger joints and lower muscle co-contraction in the finger and elbow joints. Upper limb function improved after the 20-session training, indicated by the increased clinical scores of Fugl-Meyer Assessment, Action Research Arm Test and Wolf Motor Function Test. Muscle co-contraction was reduced in the finger and elbow joints reflected by the Modified Ashworth Scale. The findings demonstrated that an electromyography-driven NMES-robot used for chronic stroke improved hand function and tracking performance. Further research is warranted to validate the method on a larger scale. Implications for Rehabilitation The hand robotics and neuromuscular electrical stimulation (NMES) techniques are still separate systems in current post-stroke hand rehabilitation. This is the first study to investigate the combined effects of the NMES and robot on hand rehabilitation. The finger tracking performance was improved with the combined assistance from the EMG-driven NMES-robot hand system. The assistance from the robot could improve the finger movement accuracy and the assistance from the NMES could reduce the muscle co-contraction on finger and elbow joints. The upper limb functions were improved on chronic stroke patients after the pilot study of 20-session hand training with the combined assistance from the EMG-driven NMES-robot. The muscle spasticity on finger and elbow joints was reduced after the training.

Studies on Materials for Heavy-Liquid-Metal-Cooled Reactors in Japan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Minoru Takahashi; Masayuki Igashira; Toru Obara

2002-07-01

Recent studies on materials for the development of lead-bismuth (Pb-Bi)-cooled fast reactors (FR) and accelerator-driven sub-critical systems (ADS) in Japan are reported. The measurement of the neutron cross section of Bi to produce {sup 210}Po, the removal experiment of Po contamination and steel corrosion test in Pb-Bi flow were performed in Tokyo Institute of Technology. A target material corrosion test was performed in the project of Transmutation Experimental Facility for ADS in Japan Atomic Energy Research Institute (JAERI). Steel corrosion test was started in Mitsui Engineering and Shipbuilding Co., LTD (MES). The feasibility study for FR cycle performed in Japanmore » Nuclear Cycle Institute (JNC) are described. (authors)« less

Sorption compressor/mechanical expander hybrid refrigeration

NASA Technical Reports Server (NTRS)

Jones, J. A.; Britcliffe, M.

1987-01-01

Experience with Deep Space Network (DSN) ground-based cryogenic refrigerators has proved the reliability of the basic two-stage Gifford-McMahon helium refrigerator. A very long life cryogenic refrigeration system appears possible by combining this expansion system or a turbo expansion system with a hydride sorption compressor in place of the usual motor driven piston compressor. To test the feasibility of this system, a commercial Gifford-McMahon refrigerator was tested using hydrogen gas as the working fluid. Although no attempt was made to optimize the system for hydrogen operation, the refrigerator developed 1.3 W at 30 K and 6.6 W at 60 K. The results of the test and of theoretical performances of the hybrid compressor coupled to these expansion systems are presented.

Using connectome-based predictive modeling to predict individual behavior from brain connectivity

PubMed Central

Shen, Xilin; Finn, Emily S.; Scheinost, Dustin; Rosenberg, Monica D.; Chun, Marvin M.; Papademetris, Xenophon; Constable, R Todd

2017-01-01

Neuroimaging is a fast developing research area where anatomical and functional images of human brains are collected using techniques such as functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), and electroencephalography (EEG). Technical advances and large-scale datasets have allowed for the development of models capable of predicting individual differences in traits and behavior using brain connectivity measures derived from neuroimaging data. Here, we present connectome-based predictive modeling (CPM), a data-driven protocol for developing predictive models of brain-behavior relationships from connectivity data using cross-validation. This protocol includes the following steps: 1) feature selection, 2) feature summarization, 3) model building, and 4) assessment of prediction significance. We also include suggestions for visualizing the most predictive features (i.e., brain connections). The final result should be a generalizable model that takes brain connectivity data as input and generates predictions of behavioral measures in novel subjects, accounting for a significant amount of the variance in these measures. It has been demonstrated that the CPM protocol performs equivalently or better than most of the existing approaches in brain-behavior prediction. However, because CPM focuses on linear modeling and a purely data-driven driven approach, neuroscientists with limited or no experience in machine learning or optimization would find it easy to implement the protocols. Depending on the volume of data to be processed, the protocol can take 10–100 minutes for model building, 1–48 hours for permutation testing, and 10–20 minutes for visualization of results. PMID:28182017

Annual Summary Report on Thermionic Cathode Project.

DTIC Science & Technology

1986-01-09

Voltage Operation The electron gun cathode is driven negative by a high voltageRadiation pulse modulator in the circuit of Figure 3-1. Typical current...tungsten filament. The bombardment heating system is stabilized by a feed- back control circuit . The power required to heat tne cathode is 315 W bom...project. The primary purpose of the first phase was to develop the bombardment heating circuit used to heat the LaB 6 cathode, and to test the beam

Proposed design modifications to reduce risk of operating rotary field mowers.

PubMed

White, K L; Wells, L G; Shearer, S A; Piercy, L R

2000-11-01

The primary objective of this project was to reduce risk of injury associated with operating a rotary mower driven by a tractor power take-off (PTO) by developing and evaluating design improvements and determining their economic feasibility. Researchers have concluded that alteration of machinery design has a greater impact on the reduction of accidents than safety training. Implementation of an Operator Presence Sensing System (OPSS) and removal of the PTO are the two injury-reducing, engineering modifications evaluated by this research. Hydraulic power allows this to occur by providing dynamic braking, few moving parts (removal of the PTO), and controllable power. A hydraulic circuit was developed to power the mower and to enable an OPSS. Tractor hydraulics were simulated using a hydraulic training bench. Two mower configurations were tested: 6.55 cm3 rev(-1) (0.4 in.3 rev(-1)) displacement motor with a 0.748 kg blade and 47.5 cm3 rev(-1) (2.9 in.3 rev(-1)) displacement motor with a 9.4 kg blade. A PTO-driven rotary mower was not used to test the circuit due to spatial and safety limitations of the hydraulic training bench. Results from the first mower configuration verified the concepts behind the hydraulic circuit. The second configuration verified the OPSS and indicated the applicability of the circuit to a rotary mower.

Implementation of density-based solver for all speeds in the framework of OpenFOAM

NASA Astrophysics Data System (ADS)

Shen, Chun; Sun, Fengxian; Xia, Xinlin

2014-10-01

In the framework of open source CFD code OpenFOAM, a density-based solver for all speeds flow field is developed. In this solver the preconditioned all speeds AUSM+(P) scheme is adopted and the dual time scheme is implemented to complete the unsteady process. Parallel computation could be implemented to accelerate the solving process. Different interface reconstruction algorithms are implemented, and their accuracy with respect to convection is compared. Three benchmark tests of lid-driven cavity flow, flow crossing over a bump, and flow over a forward-facing step are presented to show the accuracy of the AUSM+(P) solver for low-speed incompressible flow, transonic flow, and supersonic/hypersonic flow. Firstly, for the lid driven cavity flow, the computational results obtained by different interface reconstruction algorithms are compared. It is indicated that the one dimensional reconstruction scheme adopted in this solver possesses high accuracy and the solver developed in this paper can effectively catch the features of low incompressible flow. Then via the test cases regarding the flow crossing over bump and over forward step, the ability to capture characteristics of the transonic and supersonic/hypersonic flows are confirmed. The forward-facing step proves to be the most challenging for the preconditioned solvers with and without the dual time scheme. Nonetheless, the solvers described in this paper reproduce the main features of this flow, including the evolution of the initial transient.

Towards a Job Demands-Resources Health Model: Empirical Testing with Generalizable Indicators of Job Demands, Job Resources, and Comprehensive Health Outcomes

PubMed Central

Brauchli, Rebecca; Jenny, Gregor J.; Füllemann, Désirée; Bauer, Georg F.

2015-01-01

Studies using the Job Demands-Resources (JD-R) model commonly have a heterogeneous focus concerning the variables they investigate—selective job demands and resources as well as burnout and work engagement. The present study applies the rationale of the JD-R model to expand the relevant outcomes of job demands and job resources by linking the JD-R model to the logic of a generic health development framework predicting more broadly positive and negative health. The resulting JD-R health model was operationalized and tested with a generalizable set of job characteristics and positive and negative health outcomes among a heterogeneous sample of 2,159 employees. Applying a theory-driven and a data-driven approach, measures which were generally relevant for all employees were selected. Results from structural equation modeling indicated that the model fitted the data. Multiple group analyses indicated invariance across six organizations, gender, job positions, and three times of measurement. Initial evidence was found for the validity of an expanded JD-R health model. Thereby this study contributes to the current research on job characteristics and health by combining the core idea of the JD-R model with the broader concepts of salutogenic and pathogenic health development processes as well as both positive and negative health outcomes. PMID:26557718

Relational machine learning for electronic health record-driven phenotyping.

PubMed

Peissig, Peggy L; Santos Costa, Vitor; Caldwell, Michael D; Rottscheit, Carla; Berg, Richard L; Mendonca, Eneida A; Page, David

2014-12-01

Electronic health records (EHR) offer medical and pharmacogenomics research unprecedented opportunities to identify and classify patients at risk. EHRs are collections of highly inter-dependent records that include biological, anatomical, physiological, and behavioral observations. They comprise a patient's clinical phenome, where each patient has thousands of date-stamped records distributed across many relational tables. Development of EHR computer-based phenotyping algorithms require time and medical insight from clinical experts, who most often can only review a small patient subset representative of the total EHR records, to identify phenotype features. In this research we evaluate whether relational machine learning (ML) using inductive logic programming (ILP) can contribute to addressing these issues as a viable approach for EHR-based phenotyping. Two relational learning ILP approaches and three well-known WEKA (Waikato Environment for Knowledge Analysis) implementations of non-relational approaches (PART, J48, and JRIP) were used to develop models for nine phenotypes. International Classification of Diseases, Ninth Revision (ICD-9) coded EHR data were used to select training cohorts for the development of each phenotypic model. Accuracy, precision, recall, F-Measure, and Area Under the Receiver Operating Characteristic (AUROC) curve statistics were measured for each phenotypic model based on independent manually verified test cohorts. A two-sided binomial distribution test (sign test) compared the five ML approaches across phenotypes for statistical significance. We developed an approach to automatically label training examples using ICD-9 diagnosis codes for the ML approaches being evaluated. Nine phenotypic models for each ML approach were evaluated, resulting in better overall model performance in AUROC using ILP when compared to PART (p=0.039), J48 (p=0.003) and JRIP (p=0.003). ILP has the potential to improve phenotyping by independently delivering clinically expert interpretable rules for phenotype definitions, or intuitive phenotypes to assist experts. Relational learning using ILP offers a viable approach to EHR-driven phenotyping. Copyright © 2014 Elsevier Inc. All rights reserved.

Double Blind Test For Bio-Stimulation Effects On Pain Relief By Diode Laser

NASA Astrophysics Data System (ADS)

Saeki, Norio; Sembokuya, Iwajiro; Arakawa, Kazuo; Fujimasa, Iwao; Mabuchi, Kunihiko; Abe, Yuusuke; Atsumi, Kazuhiko

1989-09-01

The bio-stimulation effect of semiconductor laser on therapeutic pain relief was investigated by conducting a double blind test performed on more than one hundred patient subjects suffering from various neualgia. A compact laser therapeutic equipment with two laser probes each having 60 mW power was developed and utilized for the experiment. Each probe was driven by either the active or the dummy source selected randomly, and its results were stored in the memory for statistical processing. The therapeutic treatments including active and dummy treatments were performed on 102 subjects. The pain relief effects were confirmed for 85.5% of the subjects.

Design and evaluation of low cost blades for large wind driven generating systems

NASA Technical Reports Server (NTRS)

Eggert, W. S.

1982-01-01

The development and evaluation of a low cost blade concept based on the NASA-Lewis specifications is discussed. A blade structure was designed and construction methods and materials were selected. Complete blade tooling concepts, various technical and economic analysis, and evaluations of the blade design were performed. A comprehensive fatigue test program was conducted to provide data and to verify the design. A test specimen of the spar assembly, including the root end attachment, was fabricated. This is a full-scale specimen of the root end configuration, 20 ft long. A blade design for the Mod '0' system was completed.

Towards a Multi-Stakeholder-Driven Model for Excellence in Higher Education Curriculum Development

ERIC Educational Resources Information Center

Meyer, M. H.; Bushney, M. J.

2008-01-01

A multi-stakeholder-driven model for excellence in higher education curriculum development has been developed. It is based on the assumption that current efforts to curriculum development take place within a framework of limited stakeholder consultation. A total of 18 multiple stakeholders are identified, including learners, alumni, government,…

High Performance Visualization using Query-Driven Visualizationand Analytics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bethel, E. Wes; Campbell, Scott; Dart, Eli

2006-06-15

Query-driven visualization and analytics is a unique approach for high-performance visualization that offers new capabilities for knowledge discovery and hypothesis testing. The new capabilities akin to finding needles in haystacks are the result of combining technologies from the fields of scientific visualization and scientific data management. This approach is crucial for rapid data analysis and visualization in the petascale regime. This article describes how query-driven visualization is applied to a hero-sized network traffic analysis problem.

A classification tree approach for improving the utilization of flow cytometry testing of blood specimens for B-cell non-Hodgkin lymphoproliferative disorders.

PubMed

Healey, Ryan; Naugler, Christopher; de Koning, Lawrence; Patel, Jay L

2015-01-01

We sought to improve the diagnostic efficiency of flow cytometry investigation on blood by developing data-driven ordering guidelines. Our goal was to improve flow cytometry utilization by decreasing negative testing, therefore reducing healthcare costs. We investigated several laboratory tests performed alongside flow cytometry to identify biomarkers useful in excluding non-leukemic bloods. Test results and patient demographic features were subjected to receiver-operator characteristic (ROC) curve, logistic regression and classification tree analyses to find significant predictors and develop decision rules. Our data show that, in the absence of a compelling clinical indication, flow cytometry testing is largely non-informative on bloods from patients less than 50 years of age having an absolute lymphocyte count (ALC) below 5.0 × 10(9)/L. For patients over age 50 having an ALC below this value, a ferritin value above 450 μg/L is counter-indicative of B-cell clonality. Using these guidelines, 26% of cases were correctly predicted as negative with greater than 97% accuracy.

In situ thermomechanical testing methods for micro/nano-scale materials.

PubMed

Kang, Wonmo; Merrill, Marriner; Wheeler, Jeffrey M

2017-02-23

The advance of micro/nanotechnology in energy-harvesting, micropower, electronic devices, and transducers for automobile and aerospace applications has led to the need for accurate thermomechanical characterization of micro/nano-scale materials to ensure their reliability and performance. This persistent need has driven various efforts to develop innovative experimental techniques that overcome the critical challenges associated with precise mechanical and thermal control of micro/nano-scale specimens during material characterization. Here we review recent progress in the development of thermomechanical testing methods from miniaturized versions of conventional macroscopic test systems to the current state of the art of in situ uniaxial testing capabilities in electron microscopes utilizing either indentation-based microcompression or integrated microsystems. We discuss the major advantages/disadvantages of these methods with respect to specimen size, range of temperature control, ease of experimentation and resolution of the measurements. We also identify key challenges in each method. Finally, we summarize some of the important discoveries that have been made using in situ thermomechanical testing and the exciting research opportunities still to come in micro/nano-scale materials.

Deployment and retraction of a cable-driven solar array: Testing and simulation

NASA Technical Reports Server (NTRS)

Kumar, P.; Pellegrino, S.

1995-01-01

The paper investigates three critical areas in cable-driven rigid-panel solar arrays: First, the variation of deployment and retraction cable tensions due to friction at the hinges; Second, the change in deployment dynamics associated with different deployment histories; Third, the relationship between the level of pre-tension in the closed contact loops and the synchronization of deployment. A small scale model array has been made and tested, and its behavior has been compared to numerical simulations.

Transportability Testing of the Joint Modular Intermodal Platform (JMIP), TP-94-01, Transportability Testing Procedures

DTIC Science & Technology

2006-11-01

Serial #: T-018447EFJM Weight: 19,340 pounds 4. Semitrailer, flatbed , breakbulk/container transporter, 34 ton Model #: M872A1 Manufactured by Heller...WILL BE USED WHENEVER POS- SIBLE WHEN NAILS ARE DRIVEN INTO JOINTS OF DUNNAGE AS- SEMBLIES OR WHEN LAMINATING DUNNAGE. ADDITIONALLY, THE NAILING...PATTERN FOR AN UPPER PIECE OF LAMINATED DUNNAGE WILL BE ADJUSTED AS REQUIRED SO THAT A NAIL FOR THAT PIECE WILL NOT BE DRIVEN THROUGH, ONTO, OR RIGHT

Advances in Electrically Driven Thermal Management

NASA Technical Reports Server (NTRS)

Didion, Jeffrey R.

2017-01-01

Electrically Driven Thermal Management is a vibrant technology development initiative incorporating ISS based technology demonstrations, development of innovative fluid management techniques and fundamental research efforts. The program emphasizes high temperature high heat flux thermal management required for future generations of RF electronics and power electronic devices. This presentation reviews i.) preliminary results from the Electrohydrodynamic (EHD) Long Term Flight Demonstration launched on STP-H5 payload in February 2017 ii.) advances in liquid phase flow distribution control iii.) development of the Electrically Driven Liquid Film Boiling Experiment under the NASA Microgravity Fluid Physics Program.

Theory of Change: a theory-driven approach to enhance the Medical Research Council's framework for complex interventions

PubMed Central

2014-01-01

Background The Medical Research Councils’ framework for complex interventions has been criticized for not including theory-driven approaches to evaluation. Although the framework does include broad guidance on the use of theory, it contains little practical guidance for implementers and there have been calls to develop a more comprehensive approach. A prospective, theory-driven process of intervention design and evaluation is required to develop complex healthcare interventions which are more likely to be effective, sustainable and scalable. Methods We propose a theory-driven approach to the design and evaluation of complex interventions by adapting and integrating a programmatic design and evaluation tool, Theory of Change (ToC), into the MRC framework for complex interventions. We provide a guide to what ToC is, how to construct one, and how to integrate its use into research projects seeking to design, implement and evaluate complex interventions using the MRC framework. We test this approach by using ToC within two randomized controlled trials and one non-randomized evaluation of complex interventions. Results Our application of ToC in three research projects has shown that ToC can strengthen key stages of the MRC framework. It can aid the development of interventions by providing a framework for enhanced stakeholder engagement and by explicitly designing an intervention that is embedded in the local context. For the feasibility and piloting stage, ToC enables the systematic identification of knowledge gaps to generate research questions that strengthen intervention design. ToC may improve the evaluation of interventions by providing a comprehensive set of indicators to evaluate all stages of the causal pathway through which an intervention achieves impact, combining evaluations of intervention effectiveness with detailed process evaluations into one theoretical framework. Conclusions Incorporating a ToC approach into the MRC framework holds promise for improving the design and evaluation of complex interventions, thereby increasing the likelihood that the intervention will be ultimately effective, sustainable and scalable. We urge researchers developing and evaluating complex interventions to consider using this approach, to evaluate its usefulness and to build an evidence base to further refine the methodology. Trial registration Clinical trials.gov: NCT02160249 PMID:24996765

Theory of Change: a theory-driven approach to enhance the Medical Research Council's framework for complex interventions.

PubMed

De Silva, Mary J; Breuer, Erica; Lee, Lucy; Asher, Laura; Chowdhary, Neerja; Lund, Crick; Patel, Vikram

2014-07-05

The Medical Research Councils' framework for complex interventions has been criticized for not including theory-driven approaches to evaluation. Although the framework does include broad guidance on the use of theory, it contains little practical guidance for implementers and there have been calls to develop a more comprehensive approach. A prospective, theory-driven process of intervention design and evaluation is required to develop complex healthcare interventions which are more likely to be effective, sustainable and scalable. We propose a theory-driven approach to the design and evaluation of complex interventions by adapting and integrating a programmatic design and evaluation tool, Theory of Change (ToC), into the MRC framework for complex interventions. We provide a guide to what ToC is, how to construct one, and how to integrate its use into research projects seeking to design, implement and evaluate complex interventions using the MRC framework. We test this approach by using ToC within two randomized controlled trials and one non-randomized evaluation of complex interventions. Our application of ToC in three research projects has shown that ToC can strengthen key stages of the MRC framework. It can aid the development of interventions by providing a framework for enhanced stakeholder engagement and by explicitly designing an intervention that is embedded in the local context. For the feasibility and piloting stage, ToC enables the systematic identification of knowledge gaps to generate research questions that strengthen intervention design. ToC may improve the evaluation of interventions by providing a comprehensive set of indicators to evaluate all stages of the causal pathway through which an intervention achieves impact, combining evaluations of intervention effectiveness with detailed process evaluations into one theoretical framework. Incorporating a ToC approach into the MRC framework holds promise for improving the design and evaluation of complex interventions, thereby increasing the likelihood that the intervention will be ultimately effective, sustainable and scalable. We urge researchers developing and evaluating complex interventions to consider using this approach, to evaluate its usefulness and to build an evidence base to further refine the methodology. Clinical trials.gov: NCT02160249.

Extending the Constant Power Speed Range of the Brushless DC Motor through Dual Mode Inverter Control -- Part II: Laboratory Proof-of-Principle

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lawler, J.S.

2001-10-29

Previous theoretical work has shown that when all loss mechanisms are neglected the constant power speed range (CPSR) of a brushless dc motor (BDCM) is infinite when the motor is driven by the dual-mode inverter control (DMIC) [1,2]. In a physical drive, losses, particularly speed-sensitive losses, will limit the CPSR to a finite value. In this paper we report the results of laboratory testing of a low-inductance, 7.5-hp BDCM driven by the DMIC. The speed rating of the test motor rotor limited the upper speed of the testing, and the results show that the CPSR of the test machine ismore » greater than 6:1 when driven by the DMIC. Current wave shape, peak, and rms values remained controlled and within rating over the entire speed range. The laboratory measurements allowed the speed-sensitive losses to be quantified and incorporated into computer simulation models, which then accurately reproduce the results of lab testing. The simulator shows that the limiting CPSR of the test motor is 8:1. These results confirm that the DMIC is capable of driving low-inductance BDCMs over the wide CPSR that would be required in electric vehicle applications.« less

Uprated OMS Engine Status-Sea Level Testing Results

NASA Technical Reports Server (NTRS)

Bertolino, J. D.; Boyd, W. C.

1990-01-01

The current Space Shuttle Orbital Maneuvering Engine (OME) is pressure fed, utilizing storable propellants. Performance uprating of this engine, through the use of a gas generator driven turbopump to increase operating pressure, is being pursued by the NASA Johnson Space Center (JSC). Component level design, fabrication, and test activities for this engine system have been on-going since 1984. More recently, a complete engine designated the Integrated Component Test Bed (ICTB), was tested at sea level conditions by Aerojet. A description of the test hardware and results of the sea level test program are presented. These results, which include the test condition operating envelope and projected performance at altitude conditions, confirm the capability of the selected Uprated OME (UOME) configuration to meet or exceed performance and operational requirements. Engine flexibility, demonstrated through testing at two different operational mixture ratios, along with a summary of projected Space Shuttle performance enhancements using the UOME, are discussed. Planned future activities, including ICTB tests at simulated altitude conditions, and recommendations for further engine development, are also discussed.

Development and Characterization Testing of an Air Pulsation Valve for a Pulse Detonation Engine Supersonic Parametric Inlet Test Section

NASA Technical Reports Server (NTRS)

Tornabene, Robert

2005-01-01

In pulse detonation engines, the potential exists for gas pulses from the combustor to travel upstream and adversely affect the inlet performance of the engine. In order to determine the effect of these high frequency pulses on the inlet performance, an air pulsation valve was developed to provide air pulses downstream of a supersonic parametric inlet test section. The purpose of this report is to document the design and characterization tests that were performed on a pulsation valve that was tested at the NASA Glenn Research Center 1x1 Supersonic Wind Tunnel (SWT) test facility. The high air flow pulsation valve design philosophy and analyses performed are discussed and characterization test results are presented. The pulsation valve model was devised based on the concept of using a free spinning ball valve driven from a variable speed electric motor to generate air flow pulses at preset frequencies. In order to deliver the proper flow rate, the flow port was contoured to maximize flow rate and minimize pressure drop. To obtain sharp pressure spikes the valve flow port was designed to be as narrow as possible to minimize port dwell time.

Documentation Driven Development for Complex Real-Time Systems

DTIC Science & Technology

2004-12-01

This paper presents a novel approach for development of complex real - time systems , called the documentation-driven development (DDD) approach. This... time systems . DDD will also support automated software generation based on a computational model and some relevant techniques. DDD includes two main...stakeholders to be easily involved in development processes and, therefore, significantly improve the agility of software development for complex real

Investigation of lunar base thermal control system options

NASA Technical Reports Server (NTRS)

Ewart, Michael K.

1993-01-01

Long duration human exploration missions to the Moon will require active thermal control systems which have not previously been used in space. The two technologies which are most promising for long term lunar base thermal control are heat pumps and radiator shades. Recent trade-off studies at the Johnson Space Center have focused development efforts on the most promising heat pump and radiator shade technologies. Since these technologies are in the early stages of development and many parameters used in the study are not well defined, a parametric study was done to test the sensitivity to each assumption. The primary comparison factor in these studies was the total mass system, with power requirements included in the form of a mass penalty for power. Heat pump technologies considered were thermally driven heat pumps such as metal hydride, complex compound, absorption and zeolite. Also considered were electrically driven Stirling and vapor compression heat pumps. Radiator shade concepts considered included step shaped, V-shaped and parabolic (or catenary) shades and ground covers. A further trade study compared the masses of heat pump and radiator shade systems.

Evaluating the performance of infectious disease forecasts: A comparison of climate-driven and seasonal dengue forecasts for Mexico.

PubMed

Johansson, Michael A; Reich, Nicholas G; Hota, Aditi; Brownstein, John S; Santillana, Mauricio

2016-09-26

Dengue viruses, which infect millions of people per year worldwide, cause large epidemics that strain healthcare systems. Despite diverse efforts to develop forecasting tools including autoregressive time series, climate-driven statistical, and mechanistic biological models, little work has been done to understand the contribution of different components to improved prediction. We developed a framework to assess and compare dengue forecasts produced from different types of models and evaluated the performance of seasonal autoregressive models with and without climate variables for forecasting dengue incidence in Mexico. Climate data did not significantly improve the predictive power of seasonal autoregressive models. Short-term and seasonal autocorrelation were key to improving short-term and long-term forecasts, respectively. Seasonal autoregressive models captured a substantial amount of dengue variability, but better models are needed to improve dengue forecasting. This framework contributes to the sparse literature of infectious disease prediction model evaluation, using state-of-the-art validation techniques such as out-of-sample testing and comparison to an appropriate reference model.

Evaluating the performance of infectious disease forecasts: A comparison of climate-driven and seasonal dengue forecasts for Mexico

PubMed Central

Johansson, Michael A.; Reich, Nicholas G.; Hota, Aditi; Brownstein, John S.; Santillana, Mauricio

2016-01-01

Dengue viruses, which infect millions of people per year worldwide, cause large epidemics that strain healthcare systems. Despite diverse efforts to develop forecasting tools including autoregressive time series, climate-driven statistical, and mechanistic biological models, little work has been done to understand the contribution of different components to improved prediction. We developed a framework to assess and compare dengue forecasts produced from different types of models and evaluated the performance of seasonal autoregressive models with and without climate variables for forecasting dengue incidence in Mexico. Climate data did not significantly improve the predictive power of seasonal autoregressive models. Short-term and seasonal autocorrelation were key to improving short-term and long-term forecasts, respectively. Seasonal autoregressive models captured a substantial amount of dengue variability, but better models are needed to improve dengue forecasting. This framework contributes to the sparse literature of infectious disease prediction model evaluation, using state-of-the-art validation techniques such as out-of-sample testing and comparison to an appropriate reference model. PMID:27665707

A cable-driven parallel robots application: modelling and simulation of a dynamic cable model in Dymola

NASA Astrophysics Data System (ADS)

Othman, M. F.; Kurniawan, R.; Schramm, D.; Ariffin, A. K.

2018-05-01

Modeling a cable model in multibody dynamics simulation tool which dynamically varies in length, mass and stiffness is a challenging task. Simulation of cable-driven parallel robots (CDPR) for instance requires a cable model that can dynamically change in length for every desired pose of the platform. Thus, in this paper, a detailed procedure for modeling and simulation of a dynamic cable model in Dymola is proposed. The approach is also applicable for other types of Modelica simulation environments. The cable is modeled using standard mechanical elements like mass, spring, damper and joint. The parameters of the cable model are based on the factsheet of the manufacturer and experimental results. Its dynamic ability is tested by applying it on a complete planar CDPR model in which the parameters are based on a prototype named CABLAR, which is developed in Chair of Mechatronics, University of Duisburg-Essen. The prototype has been developed to demonstrate an application of CDPR as a goods storage and retrieval machine. The performance of the cable model during the simulation is analyzed and discussed.

Urban sprawl as a risk factor in motor vehicle crashes

USGS Publications Warehouse

Ewing, Reid; Hamidi, Shima; Grace, James B.

2016-01-01

A decade ago, compactness/sprawl indices were developed for metropolitan areas and counties which have been widely used in health and other research. In this study, we first update the original county index to 2010, then develop a refined index that accounts for more relevant factors, and finally seek to test the relationship between sprawl and traffic crash rates using structural equation modelling. Controlling for covariates, we find that sprawl is associated with significantly higher direct and indirect effects on fatal crash rates. The direct effect is likely due to the higher traffic speeds in sprawling areas, and the indirect effect is due to greater vehicle miles driven in such areas. Conversely, sprawl has negative direct relationships with total crashes and non-fatal injury crashes, and these offset (and sometimes overwhelm) the positive indirect effects of sprawl on both types of crashes through the mediating effect of increased vehicle miles driven. The most likely explanation is the greater prevalence of fender benders and other minor accidents in the low speed, high conflict traffic environments of compact areas, negating the lower vehicle miles travelled per capita in such areas.

A Verification-Driven Approach to Traceability and Documentation for Auto-Generated Mathematical Software

NASA Technical Reports Server (NTRS)

Denney, Ewen W.; Fischer, Bernd

2009-01-01

Model-based development and automated code generation are increasingly used for production code in safety-critical applications, but since code generators are typically not qualified, the generated code must still be fully tested, reviewed, and certified. This is particularly arduous for mathematical and control engineering software which requires reviewers to trace subtle details of textbook formulas and algorithms to the code, and to match requirements (e.g., physical units or coordinate frames) not represented explicitly in models or code. Both tasks are complicated by the often opaque nature of auto-generated code. We address these problems by developing a verification-driven approach to traceability and documentation. We apply the AUTOCERT verification system to identify and then verify mathematical concepts in the code, based on a mathematical domain theory, and then use these verified traceability links between concepts, code, and verification conditions to construct a natural language report that provides a high-level structured argument explaining why and how the code uses the assumptions and complies with the requirements. We have applied our approach to generate review documents for several sub-systems of NASA s Project Constellation.

SPH with dynamical smoothing length adjustment based on the local flow kinematics

NASA Astrophysics Data System (ADS)

Olejnik, Michał; Szewc, Kamil; Pozorski, Jacek

2017-11-01

Due to the Lagrangian nature of Smoothed Particle Hydrodynamics (SPH), the adaptive resolution remains a challenging task. In this work, we first analyse the influence of the simulation parameters and the smoothing length on solution accuracy, in particular in high strain regions. Based on this analysis we develop a novel approach to dynamically adjust the kernel range for each SPH particle separately, accounting for the local flow kinematics. We use the Okubo-Weiss parameter that distinguishes the strain and vorticity dominated regions in the flow domain. The proposed development is relatively simple and implies only a moderate computational overhead. We validate the modified SPH algorithm for a selection of two-dimensional test cases: the Taylor-Green flow, the vortex spin-down, the lid-driven cavity and the dam-break flow against a sharp-edged obstacle. The simulation results show good agreement with the reference data and improvement of the long-term accuracy for unsteady flows. For the lid-driven cavity case, the proposed dynamical adjustment remedies the problem of tensile instability (particle clustering).

Ready, Set, Change! Development and usability testing of an online readiness for change decision support tool for healthcare organizations.

PubMed

Timmings, Caitlyn; Khan, Sobia; Moore, Julia E; Marquez, Christine; Pyka, Kasha; Straus, Sharon E

2016-02-24

To address challenges related to selecting a valid, reliable, and appropriate readiness assessment measure in practice, we developed an online decision support tool to aid frontline implementers in healthcare settings in this process. The focus of this paper is to describe a multi-step, end-user driven approach to developing this tool for use during the planning stages of implementation. A multi-phase, end-user driven approach was used to develop and test the usability of a readiness decision support tool. First, readiness assessment measures that are valid, reliable, and appropriate for healthcare settings were identified from a systematic review. Second, a mapping exercise was performed to categorize individual items of included measures according to key readiness constructs from an existing framework. Third, a modified Delphi process was used to collect stakeholder ratings of the included measures on domains of feasibility, relevance, and likelihood to recommend. Fourth, two versions of a decision support tool prototype were developed and evaluated for usability. Nine valid and reliable readiness assessment measures were included in the decision support tool. The mapping exercise revealed that of the nine measures, most measures (78 %) focused on assessing readiness for change at the organizational versus the individual level, and that four measures (44 %) represented all constructs of organizational readiness. During the modified Delphi process, stakeholders rated most measures as feasible and relevant for use in practice, and reported that they would be likely to recommend use of most measures. Using data from the mapping exercise and stakeholder panel, an algorithm was developed to link users to a measure based on characteristics of their organizational setting and their readiness for change assessment priorities. Usability testing yielded recommendations that were used to refine the Ready, Set, Change! decision support tool . Ready, Set, Change! decision support tool is an implementation support that is designed to facilitate the routine incorporation of a readiness assessment as an early step in implementation. Use of this tool in practice may offer time and resource-saving implications for implementation.

Modeling the sustainable development of innovation in transport construction based on the communication approach

NASA Astrophysics Data System (ADS)

Revunova, Svetlana; Vlasenko, Vyacheslav; Bukreev, Anatoly

2017-10-01

The article proposes the models of innovative activity development, which is driven by the formation of “points of innovation-driven growth”. The models are based on the analysis of the current state and dynamics of innovative development of construction enterprises in the transport sector and take into account a number of essential organizational and economic changes in management. The authors substantiate implementing such development models as an organizational innovation that has a communication genesis. The use of the communication approach to the formation of “points of innovation-driven growth” allowed the authors to apply the mathematical tools of the graph theory in order to activate the innovative activity of the transport industry in the region. As a result, the authors have proposed models that allow constructing an optimal mechanism for the formation of “points of innovation-driven growth”.

Compiler-Driven Performance Optimization and Tuning for Multicore Architectures

DTIC Science & Technology

2015-04-10

develop a powerful system for auto-tuning of library routines and compute-intensive kernels, driven by the Pluto system for multicores that we are...kernels, driven by the Pluto system for multicores that we are developing. The work here is motivated by recent advances in two major areas of...automatic C-to-CUDA code generator using a polyhedral compiler transformation framework. We have used and adapted PLUTO (our state-of-the-art tool

CrossTalk. The Journal of Defense Software Engineering. Volume 23, Number 6, Nov/Dec 2010

DTIC Science & Technology

2010-11-01

Model of archi- tectural design. It guides developers to apply effort to their software architecture commensurate with the risks faced by...Driven Model is the promotion of risk to prominence. It is possible to apply the Risk-Driven Model to essentially any software development process...succeed without any planned architecture work, while many high-risk projects would fail without it . The Risk-Driven Model walks a middle path

Graphical programming interface: A development environment for MRI methods.

PubMed

Zwart, Nicholas R; Pipe, James G

2015-11-01

To introduce a multiplatform, Python language-based, development environment called graphical programming interface for prototyping MRI techniques. The interface allows developers to interact with their scientific algorithm prototypes visually in an event-driven environment making tasks such as parameterization, algorithm testing, data manipulation, and visualization an integrated part of the work-flow. Algorithm developers extend the built-in functionality through simple code interfaces designed to facilitate rapid implementation. This article shows several examples of algorithms developed in graphical programming interface including the non-Cartesian MR reconstruction algorithms for PROPELLER and spiral as well as spin simulation and trajectory visualization of a FLORET example. The graphical programming interface framework is shown to be a versatile prototyping environment for developing numeric algorithms used in the latest MR techniques. © 2014 Wiley Periodicals, Inc.

Computational Fluid Dynamics Simulation of Flows in an Oxidation Ditch Driven by a New Surface Aerator.

PubMed

Huang, Weidong; Li, Kun; Wang, Gan; Wang, Yingzhe

2013-11-01

In this article, we present a newly designed inverse umbrella surface aerator, and tested its performance in driving flow of an oxidation ditch. Results show that it has a better performance in driving the oxidation ditch than the original one with higher average velocity and more uniform flow field. We also present a computational fluid dynamics model for predicting the flow field in an oxidation ditch driven by a surface aerator. The improved momentum source term approach to simulate the flow field of the oxidation ditch driven by an inverse umbrella surface aerator was developed and validated through experiments. Four kinds of turbulent models were investigated with the approach, including the standard k - ɛ model, RNG k - ɛ model, realizable k - ɛ model, and Reynolds stress model, and the predicted data were compared with those calculated with the multiple rotating reference frame approach (MRF) and sliding mesh approach (SM). Results of the momentum source term approach are in good agreement with the experimental data, and its prediction accuracy is better than MRF, close to SM. It is also found that the momentum source term approach has lower computational expenses, is simpler to preprocess, and is easier to use.

A zebrafish model of chordoma initiated by notochord-driven expression of HRASV12

PubMed Central

Burger, Alexa; Vasilyev, Aleksandr; Tomar, Ritu; Selig, Martin K.; Nielsen, G. Petur; Peterson, Randall T.; Drummond, Iain A.; Haber, Daniel A.

2014-01-01

Chordoma is a malignant tumor thought to arise from remnants of the embryonic notochord, with its origin in the bones of the axial skeleton. Surgical resection is the standard treatment, usually in combination with radiation therapy, but neither chemotherapeutic nor targeted therapeutic approaches have demonstrated success. No animal model and only few chordoma cell lines are available for preclinical drug testing, and, although no druggable genetic drivers have been identified, activation of EGFR and downstream AKT-PI3K pathways have been described. Here, we report a zebrafish model of chordoma, based on stable transgene-driven expression of HRASV12 in notochord cells during development. Extensive intra-notochordal tumor formation is evident within days of transgene expression, ultimately leading to larval death. The zebrafish tumors share characteristics of human chordoma as demonstrated by immunohistochemistry and electron microscopy. The mTORC1 inhibitor rapamycin, which has some demonstrated activity in a chordoma cell line, delays the onset of tumor formation in our zebrafish model, and improves survival of tumor-bearing fish. Consequently, the HRASV12-driven zebrafish model of chordoma could enable high-throughput screening of potential therapeutic agents for the treatment of this refractory cancer. PMID:24311731

Dynamically adaptive data-driven simulation of extreme hydrological flows

NASA Astrophysics Data System (ADS)

Kumar Jain, Pushkar; Mandli, Kyle; Hoteit, Ibrahim; Knio, Omar; Dawson, Clint

2018-02-01

Hydrological hazards such as storm surges, tsunamis, and rainfall-induced flooding are physically complex events that are costly in loss of human life and economic productivity. Many such disasters could be mitigated through improved emergency evacuation in real-time and through the development of resilient infrastructure based on knowledge of how systems respond to extreme events. Data-driven computational modeling is a critical technology underpinning these efforts. This investigation focuses on the novel combination of methodologies in forward simulation and data assimilation. The forward geophysical model utilizes adaptive mesh refinement (AMR), a process by which a computational mesh can adapt in time and space based on the current state of a simulation. The forward solution is combined with ensemble based data assimilation methods, whereby observations from an event are assimilated into the forward simulation to improve the veracity of the solution, or used to invert for uncertain physical parameters. The novelty in our approach is the tight two-way coupling of AMR and ensemble filtering techniques. The technology is tested using actual data from the Chile tsunami event of February 27, 2010. These advances offer the promise of significantly transforming data-driven, real-time modeling of hydrological hazards, with potentially broader applications in other science domains.

Precision vector control of a superconducting RF cavity driven by an injection locked magnetron

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chase, Brian; Pasquinelli, Ralph; Cullerton, Ed

The technique presented in this paper enables the regulation of both radio frequency amplitude and phase in narrow band devices such as a Superconducting RF (SRF) cavity driven by constant power output devices i.e. magnetrons [1]. The ability to use low cost high efficiency magnetrons for accelerator RF power systems, with tight vector regulation, presents a substantial cost savings in both construction and operating costs - compared to current RF power system technology. An operating CW system at 2.45 GHz has been experimentally developed. Vector control of an injection locked magnetron has been extensively tested and characterized with a SRFmore » cavity as the load. Amplitude dynamic range of 30 dB, amplitude stability of 0.3% r.m.s, and phase stability of 0.26 degrees r.m.s. has been demonstrated.« less

Explosively driven hypervelocity launcher: Second-stage augmentation techniques

NASA Technical Reports Server (NTRS)

Baum, D. W.

1973-01-01

The results are described of a continuing study aimed at developing a two-stage explosively driven hypervelocity launcher capable of achieving projectile velocities between 15 and 20 km/sec. The testing and evaluation of a new cylindrical impact technique for collapsing the barrel of two-stage launcher are reported. Previous two-stage launchers have been limited in ultimate performance by incomplete barrel collapse behind the projectile. The cylindrical impact technique explosively collapses a steel tube concentric with and surrounding the barrel of the launcher. The impact of the tube on the barrel produces extremely high stresses which cause the barrel to collapse. The collapse rate can be adjusted by appropriate variation of the explosive charge and tubing parameters. Launcher experiments demonstrated that the technique did achieve complete barrel collapse and form a second-stage piston. However, jetting occurred in the barrel collapse process and was responsible for severe projectile damage.

Precision vector control of a superconducting RF cavity driven by an injection locked magnetron

DOE PAGES

Chase, Brian; Pasquinelli, Ralph; Cullerton, Ed; ...

2015-03-01

The technique presented in this paper enables the regulation of both radio frequency amplitude and phase in narrow band devices such as a Superconducting RF (SRF) cavity driven by constant power output devices i.e. magnetrons [1]. The ability to use low cost high efficiency magnetrons for accelerator RF power systems, with tight vector regulation, presents a substantial cost savings in both construction and operating costs - compared to current RF power system technology. An operating CW system at 2.45 GHz has been experimentally developed. Vector control of an injection locked magnetron has been extensively tested and characterized with a SRFmore » cavity as the load. Amplitude dynamic range of 30 dB, amplitude stability of 0.3% r.m.s, and phase stability of 0.26 degrees r.m.s. has been demonstrated.« less

Performance of a vane driven-gear pump

NASA Technical Reports Server (NTRS)

Heald, R H

1921-01-01

Given here are the results of a test conducted in a wind tunnel on the performance of a vane-driven gear pump used to pump gasoline upward into a small tank located within the upper wing from which it flows by gravity to the engine carburetor. Information is given on the efficiency of the pump, the head resistance of the vanes, the performance and characteristics of the unit with and without housing about the vanes, the pump performance when motor driven, and resistance and power characteristics.

Apparatus for generating quasi-free-space microwave-driven plasmas

NASA Astrophysics Data System (ADS)

Hoff, Brad W.; French, David M.; Reid, Remington R.; Lawrance, Julie E.; Lepell, P. David; Maestas, Sabrina S.

2016-03-01

An apparatus for generating quasi-free-space microwave-driven plasmas has been designed, constructed, and tested. The plasma is driven by a multi-kW, ˜5 GHz microwave beam focused at the center of a vacuum chamber using a Koch-type metal plate lens. Sustained plasma discharges have been generated in argon at pressures ranging from 150 to 200 mTorr, at beam power levels ranging from 5 to 10 kW, and at gas flow rates of approximately 200 SCCM.

BUD31 and Lipid Metabolism: A New Potential Therapeutic Entry Point for Myc-Driven Breast Cancer

DTIC Science & Technology

2016-02-01

AWARD NUMBER: W81XWH-14-1-0039 TITLE: BUD31 and Lipid Metabolism: A New Potential Therapeutic Entry Point for Myc-Driven Breast Cancer...TITLE AND SUBTITLE 5a. CONTRACT NUMBER BUD31 and Lipid Metabolism: A New Potential Therapeutic Entry Point for Myc-Driven Breast Cancer 5b. GRANT...To directly test the hypothesis above, we propose the following specific aims. AIM1: To determine if BUD31 interactions with lipid metabolism

Apparatus for generating quasi-free-space microwave-driven plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoff, Brad W.; French, David M.; Reid, Remington R.

An apparatus for generating quasi-free-space microwave-driven plasmas has been designed, constructed, and tested. The plasma is driven by a multi-kW, ∼5 GHz microwave beam focused at the center of a vacuum chamber using a Koch-type metal plate lens. Sustained plasma discharges have been generated in argon at pressures ranging from 150 to 200 mTorr, at beam power levels ranging from 5 to 10 kW, and at gas flow rates of approximately 200 SCCM.

Apparatus for generating quasi-free-space microwave-driven plasmas.

PubMed

Hoff, Brad W; French, David M; Reid, Remington R; Lawrance, Julie E; Lepell, P David; Maestas, Sabrina S

2016-03-01

An apparatus for generating quasi-free-space microwave-driven plasmas has been designed, constructed, and tested. The plasma is driven by a multi-kW, ∼5 GHz microwave beam focused at the center of a vacuum chamber using a Koch-type metal plate lens. Sustained plasma discharges have been generated in argon at pressures ranging from 150 to 200 mTorr, at beam power levels ranging from 5 to 10 kW, and at gas flow rates of approximately 200 SCCM.

Linking the development and functioning of a carnivorous pitcher plant's microbial digestive community.

PubMed

Armitage, David W

2017-11-01

Ecosystem development theory predicts that successional turnover in community composition can influence ecosystem functioning. However, tests of this theory in natural systems are made difficult by a lack of replicable and tractable model systems. Using the microbial digestive associates of a carnivorous pitcher plant, I tested hypotheses linking host age-driven microbial community development to host functioning. Monitoring the yearlong development of independent microbial digestive communities in two pitcher plant populations revealed a number of trends in community succession matching theoretical predictions. These included mid-successional peaks in bacterial diversity and metabolic substrate use, predictable and parallel successional trajectories among microbial communities, and convergence giving way to divergence in community composition and carbon substrate use. Bacterial composition, biomass, and diversity positively influenced the rate of prey decomposition, which was in turn positively associated with a host leaf's nitrogen uptake efficiency. Overall digestive performance was greatest during late summer. These results highlight links between community succession and ecosystem functioning and extend succession theory to host-associated microbial communities.

Aerodynamic force measurement on a large-scale model in a short duration test facility

NASA Astrophysics Data System (ADS)

Tanno, H.; Kodera, M.; Komuro, T.; Sato, K.; Takahasi, M.; Itoh, K.

2005-03-01

A force measurement technique has been developed for large-scale aerodynamic models with a short test time. The technique is based on direct acceleration measurements, with miniature accelerometers mounted on a test model suspended by wires. Measuring acceleration at two different locations, the technique can eliminate oscillations from natural vibration of the model. The technique was used for drag force measurements on a 3m long supersonic combustor model in the HIEST free-piston driven shock tunnel. A time resolution of 350μs is guaranteed during measurements, whose resolution is enough for ms order test time in HIEST. To evaluate measurement reliability and accuracy, measured values were compared with results from a three-dimensional Navier-Stokes numerical simulation. The difference between measured values and numerical simulation values was less than 5%. We conclude that this measurement technique is sufficiently reliable for measuring aerodynamic force within test durations of 1ms.

Response of soleus Ia afferents to vibration in the presence of the tonic vibration reflex in the decerebrate cat.

PubMed

Clark, F J; Matthews, P B; Muir, R B

1981-02-01

1. Micro-electrode recordings were made from single Ia afferents in the intact nerve to the soleus muscle in the decerebrate cat while the muscle was developing a tonic vibration reflex. This was done in order to test how effectively the afferents were excited by the vibration, and to see if any insecurity in driving might be related to tremor.2. When the amplitude of vibration was 50 mum, and the tonic vibration reflex was reasonably well developed (> 1 N of active tension) all but one of forty-four Ia afferents were driven 1:1 by the vibration. Most were still driven by 30 mum vibration. The vibration, consisting of a train of discrete pulses at 150 Hz, was applied longitudinally in combination with a stretch of 1 mm to make the muscle taut.3. If the reflex was poorly developed (active tension < 1 N) the driving was on average less secure. However, fourteen of eighteen afferents then studied were still driven 1:1 by 50 mum vibration. The lower level of excitation by vibration was thought to be due to a deficiency of spontaneous fusimotor activity, because stroking the cat's tail or other similar gentle manipulation led each of the three misbehaving afferents so tested to be driven securely by 50 mum vibration; at the same time the reflex tension increased.4. Additional, indirect evidence favouring widespread security of Ia driving by 50 mum vibration in the presence of the reflex was obtained by modulating the amplitude of the 150 Hz vibration with a 7-10 Hz square wave and detecting any tension fluctuations at that frequency by spectral analysis. Small degrees of modulation (e.g. < 10%) produced little if any effect, although larger depths of modulation had a powerful action.5. When the amplitude of vibration was reduced to permit insecure driving but still to elicit a reflex response, the fluctuations in Ia firing pattern were unlike those previously seen in the de-efferented muscle. Spectral analysis showed that these firing fluctuations bore a general similarity to the tremor in the same preparation, but measurement of coherence demonstrated that the tremor and Ia firing were not well related. This was probably because individual Ia afferents were primarily influenced by local factors, and provides further evidence against the tremor of this preparation being attributable to the action of the stretch reflex.

Response of soleus Ia afferents to vibration in the presence of the tonic vibration reflex in the decerebrate cat

PubMed Central

Clark, F. J.; Matthews, P. B. C.; Muir, R. B.

1981-01-01

1. Micro-electrode recordings were made from single Ia afferents in the intact nerve to the soleus muscle in the decerebrate cat while the muscle was developing a tonic vibration reflex. This was done in order to test how effectively the afferents were excited by the vibration, and to see if any insecurity in driving might be related to tremor. 2. When the amplitude of vibration was 50 μm, and the tonic vibration reflex was reasonably well developed (> 1 N of active tension) all but one of forty-four Ia afferents were driven 1:1 by the vibration. Most were still driven by 30 μm vibration. The vibration, consisting of a train of discrete pulses at 150 Hz, was applied longitudinally in combination with a stretch of 1 mm to make the muscle taut. 3. If the reflex was poorly developed (active tension < 1 N) the driving was on average less secure. However, fourteen of eighteen afferents then studied were still driven 1:1 by 50 μm vibration. The lower level of excitation by vibration was thought to be due to a deficiency of spontaneous fusimotor activity, because stroking the cat's tail or other similar gentle manipulation led each of the three misbehaving afferents so tested to be driven securely by 50 μm vibration; at the same time the reflex tension increased. 4. Additional, indirect evidence favouring widespread security of Ia driving by 50 μm vibration in the presence of the reflex was obtained by modulating the amplitude of the 150 Hz vibration with a 7-10 Hz square wave and detecting any tension fluctuations at that frequency by spectral analysis. Small degrees of modulation (e.g. < 10%) produced little if any effect, although larger depths of modulation had a powerful action. 5. When the amplitude of vibration was reduced to permit insecure driving but still to elicit a reflex response, the fluctuations in Ia firing pattern were unlike those previously seen in the de-efferented muscle. Spectral analysis showed that these firing fluctuations bore a general similarity to the tremor in the same preparation, but measurement of coherence demonstrated that the tremor and Ia firing were not well related. This was probably because individual Ia afferents were primarily influenced by local factors, and provides further evidence against the tremor of this preparation being attributable to the action of the stretch reflex. PMID:7264987

Engineering development studies for integrated evacuated CPC arrays

NASA Astrophysics Data System (ADS)

Winston, R.

1982-04-01

An evacuated tube concentrator which achieves respectable high temperature performance (100 C to 300 C) was developed. The design concept utilizes nonimaging CPC type concentration integrated into each tube by shaping the outer glass vacuum envelope. The detailed design, prototype fabrication and preliminary test measurements are reviewed. In addition the results of this first study specifically devoted to engineering development questions related to practical applications of this collector concept are summarized. Questions having to do with the deployment of medium to large area arrays, optimizations of the manifolding of individual tube panels, selected near term applications (with an emphasis on residential cooling based on Rankine driven chillers) and long term performance projections are addressed.

Audiologist-driven versus patient-driven fine tuning of hearing instruments.

PubMed

Boymans, Monique; Dreschler, Wouter A

2012-03-01

Two methods of fine tuning the initial settings of hearing aids were compared: An audiologist-driven approach--using real ear measurements and a patient-driven fine-tuning approach--using feedback from real-life situations. The patient-driven fine tuning was conducted by employing the Amplifit(®) II system using audiovideo clips. The audiologist-driven fine tuning was based on the NAL-NL1 prescription rule. Both settings were compared using the same hearing aids in two 6-week trial periods following a randomized blinded cross-over design. After each trial period, the settings were evaluated by insertion-gain measurements. Performance was evaluated by speech tests in quiet, in noise, and in time-reversed speech, presented at 0° and with spatially separated sound sources. Subjective results were evaluated using extensive questionnaires and audiovisual video clips. A total of 73 participants were included. On average, higher gain values were found for the audiologist-driven settings than for the patient-driven settings, especially at 1000 and 2000 Hz. Better objective performance was obtained for the audiologist-driven settings for speech perception in quiet and in time-reversed speech. This was supported by better scores on a number of subjective judgments and in the subjective ratings of video clips. The perception of loud sounds scored higher than when patient-driven, but the overall preference was in favor of the audiologist-driven settings for 67% of the participants.

Dual roles of infrared imaging on a university campus: serving the physical plant while enhancing a technology-based curriculum

NASA Astrophysics Data System (ADS)

Miles, Jonathan J.

2001-03-01

The campus of a comprehensive, residential university is in many respects a small city unto itself. All the amenities and services one would expect in a typical community are readily available on a college campus, including residences, athletic and dining facilities, libraries, and stores. A large campus, therefore, requires a reliable energy plant to provide steam, hot water, chilled water, and electricity. James Madison University supports two power plants: a vintage steam plant and a modern resource recovery facility comprising two solid-waste incinerators and two gas-fired units for steam generation, three steam-driven absorption- chilling units, and a single steam-driven generator for peak electricity production. Infrared imaging, as a teaching tool, was introduced in the Program of Integrated Science and Technology at James Madison University in 1997. The Infrared Development and Thermal Testing Laboratory was established at the university later in 1997 with government and industry support, and it is presently equipped with infrared imagers and scanners, single-point detectors, and data-acquisition systems. A study was conducted between 1998 and 1999 to test the economic feasibility of implementing an IR-based predictive maintenance program in the university steam plant. This paper describes the opportunities created at James Madison University to develop IR-based predictive maintenance programs that enhance the operation of the university energy plants; to establish IR-related research and development activities that support government and industry activities; and to enhance a science- and technology-based curriculum by way of unique, IR-based laboratory experiences and demonstrations.

Development and application of an atmospheric-hydrologic-hydraulic flood forecasting model driven by TIGGE ensemble forecasts

NASA Astrophysics Data System (ADS)

Bao, Hongjun; Zhao, Linna

2012-02-01

A coupled atmospheric-hydrologic-hydraulic ensemble flood forecasting model, driven by The Observing System Research and Predictability Experiment (THORPEX) Interactive Grand Global Ensemble (TIGGE) data, has been developed for flood forecasting over the Huaihe River. The incorporation of numerical weather prediction (NWP) information into flood forecasting systems may increase forecast lead time from a few hours to a few days. A single NWP model forecast from a single forecast center, however, is insufficient as it involves considerable non-predictable uncertainties and leads to a high number of false alarms. The availability of global ensemble NWP systems through TIGGE offers a new opportunity for flood forecast. The Xinanjiang model used for hydrological rainfall-runoff modeling and the one-dimensional unsteady flow model applied to channel flood routing are coupled with ensemble weather predictions based on the TIGGE data from the Canadian Meteorological Centre (CMC), the European Centre for Medium-Range Weather Forecasts (ECMWF), the UK Met Office (UKMO), and the US National Centers for Environmental Prediction (NCEP). The developed ensemble flood forecasting model is applied to flood forecasting of the 2007 flood season as a test case. The test case is chosen over the upper reaches of the Huaihe River above Lutaizi station with flood diversion and retarding areas. The input flood discharge hydrograph from the main channel to the flood diversion area is estimated with the fixed split ratio of the main channel discharge. The flood flow inside the flood retarding area is calculated as a reservoir with the water balance method. The Muskingum method is used for flood routing in the flood diversion area. A probabilistic discharge and flood inundation forecast is provided as the end product to study the potential benefits of using the TIGGE ensemble forecasts. The results demonstrate satisfactory flood forecasting with clear signals of probability of floods up to a few days in advance, and show that TIGGE ensemble forecast data are a promising tool for forecasting of flood inundation, comparable with that driven by raingauge observations.

Developing novel peat isotope proxies from vascular plant-dominated peatlands of New Zealand to reconstruct Southern Hemisphere climate dynamics

NASA Astrophysics Data System (ADS)

Roland, T.; Amesbury, M. J.; Charman, D.; Newnham, R.; Royles, J.; Griffiths, H.; Ratcliffe, J.; Rees, A.; Campbell, D.; Baisden, T.; Keller, E. D.

2017-12-01

The Southern Annular Mode (SAM) is a key control on the strength and position of the southern westerly winds (SWW), which are a major influence on Southern Hemisphere (SH) mid- to high-latitude climate. A shift towards a more positive SAM has occurred since the 1950s, driven by ozone layer thinning and enhanced by greenhouse gas driven warming. Although these recent changes are thought to be unprecedented over the last 1000 years, the longer-term behaviour of the SAM is poorly understood. We are developing stable isotope proxies from plant cellulose in vascular plant-dominated (Empodisma spp.) peatlands in New Zealand that we hypothesise are related to changes in past temperature (δ13C) and precipitation moisture source (δ18O). The moisture source signal is driven by the balance between Southern Ocean sources (depleted δ18O) and sub-tropical sources (enriched δ18O), reflecting the relative states of SAM and the El Niño-Southern Oscillation. We aim to provide palaeoclimatic context for the recent positive trend in the SAM, and explore the long-term relationship between the SAM and ENSO, testing the contention that tropical Pacific variability is a key influence on past and future SAM variability. Terrestrial palaeoclimate records in the Southern Hemisphere are often spatially isolated and temporally fragmented. However, New Zealand is ideally placed to test such hypotheses as it registers strong correlations between SAM, temperature and precipitation, and it straddles the zone of interaction between the SWW and sub-tropical moisture sources, reflected in a strong precipitation δ18O gradient. We report data from surface samples across New Zealand and explore the spatial and temporal patterns in stable isotopes in cellulose and water that we will use to interpret the palaeoenvironmental data. Preliminary downcore data will be used to demonstrate the efficacy of this approach to reconstructing moisture sources and temperature linked to moisture source variability.

Calculation of three-dimensional (3-D) internal flow by means of the velocity-vorticity formulation on a staggered grid

NASA Technical Reports Server (NTRS)

Stremel, Paul M.

1995-01-01

A method has been developed to accurately compute the viscous flow in three-dimensional (3-D) enclosures. This method is the 3-D extension of a two-dimensional (2-D) method developed for the calculation of flow over airfoils. The 2-D method has been tested extensively and has been shown to accurately reproduce experimental results. As in the 2-D method, the 3-D method provides for the non-iterative solution of the incompressible Navier-Stokes equations by means of a fully coupled implicit technique. The solution is calculated on a body fitted computational mesh incorporating a staggered grid methodology. In the staggered grid method, the three components of vorticity are defined at the centers of the computational cell sides, while the velocity components are defined as normal vectors at the centers of the computational cell faces. The staggered grid orientation provides for the accurate definition of the vorticity components at the vorticity locations, the divergence of vorticity at the mesh cell nodes and the conservation of mass at the mesh cell centers. The solution is obtained by utilizing a fractional step solution technique in the three coordinate directions. The boundary conditions for the vorticity and velocity are calculated implicitly as part of the solution. The method provides for the non-iterative solution of the flow field and satisfies the conservation of mass and divergence of vorticity to machine zero at each time step. To test the method, the calculation of simple driven cavity flows have been computed. The driven cavity flow is defined as the flow in an enclosure driven by a moving upper plate at the top of the enclosure. To demonstrate the ability of the method to predict the flow in arbitrary cavities, results will he shown for both cubic and curved cavities.

Simulation and performance of brushless dc motor actuators

NASA Astrophysics Data System (ADS)

Gerba, A., Jr.

1985-12-01

The simulation model for a Brushless D.C. Motor and the associated commutation power conditioner transistor model are presented. The necessary conditions for maximum power output while operating at steady-state speed and sinusoidally distributed air-gap flux are developed. Comparison of simulated model with the measured performance of a typical motor are done both on time response waveforms and on average performance characteristics. These preliminary results indicate good agreement. Plans for model improvement and testing of a motor-driven positioning device for model evaluation are outlined.

Shock Tunnel Studies of Scramjet Phenomena 1994

NASA Technical Reports Server (NTRS)

Morgan, R. G.; Paull, A.; Stalker, R. J.

1997-01-01

Reports by the research staff and graduate students of the Mechanical Engineering Department at the University of Queensland are collected and presented. These reports cover various studies related to the advancement of scramjet technology and the operation of advanced hypervelocity shock-expansion tubes. The report topics include the experimental studies of mixing and combustion in a scramjet flow path, the measurement of integrated thrust and skin friction, and the development of a free-piston-driven expansion tunnel capable of delivering a test gas at superorbital velocities.

Shock Tunnel Studies of Scramjet Phenomena 1995. Supplement 13

NASA Technical Reports Server (NTRS)

Morgan, R. G.; Stalker, R. J.; Paull, A.

1997-01-01

Reports by the research staff and graduate students of the Mechanical Engineering Department at the University of Queensland are collected and presented. These reports cover various studies related to the advancement of scramjet technology and the operation of advanced hypervelocity shock-expansion tubes. The report topics include the experimental studies of mixing and combustion in a scramjet flow path, the measurement of integrated thrust and skin friction, and the development of a free-piston-driven expansion tunnel capable delivering a test gas at super orbital velocities.

A Study of Enabling Factors for Rapid Fielding: Combined Practices to Balance Speed and Stability

DTIC Science & Technology

2013-05-01

as contributors to the success of Agile projects, such as Scrum status meetings, continuous integration, test-driven development, etc. A second...Management Approach Type Product Size Team Size Sprint length / Prod Release Cycle A-P1 Pre- release Scrum Case management system ᝺M...SLOC 10-20 2 weeks/ TBD B-P1 12 years Scrum Analysis support system ᝺M SLOC 10-20 2 weeks/ 6 months – 1 year C-P1 3 years Scrum Training

A new practice-driven approach to develop software in a cyber-physical system environment

NASA Astrophysics Data System (ADS)

Jiang, Yiping; Chen, C. L. Philip; Duan, Junwei

2016-02-01

Cyber-physical system (CPS) is an emerging area, which cannot work efficiently without proper software handling of the data and business logic. Software and middleware is the soul of the CPS. The software development of CPS is a critical issue because of its complicity in a large scale realistic system. Furthermore, object-oriented approach (OOA) is often used to develop CPS software, which needs some improvements according to the characteristics of CPS. To develop software in a CPS environment, a new systematic approach is proposed in this paper. It comes from practice, and has been evolved from software companies. It consists of (A) Requirement analysis in event-oriented way, (B) architecture design in data-oriented way, (C) detailed design and coding in object-oriented way and (D) testing in event-oriented way. It is a new approach based on OOA; the difference when compared with OOA is that the proposed approach has different emphases and measures in every stage. It is more accord with the characteristics of event-driven CPS. In CPS software development, one should focus on the events more than the functions or objects. A case study of a smart home system is designed to reveal the effectiveness of the approach. It shows that the approach is also easy to be operated in the practice owing to some simplifications. The running result illustrates the validity of this approach.

30 CFR 18.69 - Adequacy tests.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Adequacy tests. 18.69 Section 18.69 Mineral... MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Inspections and Tests § 18.69 Adequacy tests. MSHA reserves the right to conduct appropriate test(s) to verify the adequacy of equipment...

30 CFR 18.69 - Adequacy tests.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Adequacy tests. 18.69 Section 18.69 Mineral... MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Inspections and Tests § 18.69 Adequacy tests. MSHA reserves the right to conduct appropriate test(s) to verify the adequacy of equipment...

30 CFR 18.69 - Adequacy tests.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Adequacy tests. 18.69 Section 18.69 Mineral... MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Inspections and Tests § 18.69 Adequacy tests. MSHA reserves the right to conduct appropriate test(s) to verify the adequacy of equipment...

Genetic testing for exercise prescription and injury prevention: AIS-Athlome consortium-FIMS joint statement.

PubMed

Vlahovich, Nicole; Hughes, David C; Griffiths, Lyn R; Wang, Guan; Pitsiladis, Yannis P; Pigozzi, Fabio; Bachl, Nobert; Eynon, Nir

2017-11-14

There has been considerable growth in basic knowledge and understanding of how genes are influencing response to exercise training and predisposition to injuries and chronic diseases. On the basis of this knowledge, clinical genetic tests may in the future allow the personalisation and optimisation of physical activity, thus providing an avenue for increased efficiency of exercise prescription for health and disease. This review provides an overview of the current status of genetic testing for the purposes of exercise prescription and injury prevention. As such there are a variety of potential uses for genetic testing, including identification of risks associated with participation in sport and understanding individual response to particular types of exercise. However, there are many challenges remaining before genetic testing has evidence-based practical applications; including adoption of international standards for genomics research, as well as resistance against the agendas driven by direct-to-consumer genetic testing companies. Here we propose a way forward to develop an evidence-based approach to support genetic testing for exercise prescription and injury prevention. Based on current knowledge, there is no current clinical application for genetic testing in the area of exercise prescription and injury prevention, however the necessary steps are outlined for the development of evidence-based clinical applications involving genetic testing.

Data-driven prognosis: a multi-physics approach verified via balloon burst experiment.

PubMed

Chandra, Abhijit; Kar, Oliva

2015-04-08

A multi-physics formulation for data-driven prognosis (DDP) is developed. Unlike traditional predictive strategies that require controlled offline measurements or 'training' for determination of constitutive parameters to derive the transitional statistics, the proposed DDP algorithm relies solely on in situ measurements. It uses a deterministic mechanics framework, but the stochastic nature of the solution arises naturally from the underlying assumptions regarding the order of the conservation potential as well as the number of dimensions involved. The proposed DDP scheme is capable of predicting onset of instabilities. Because the need for offline testing (or training) is obviated, it can be easily implemented for systems where such a priori testing is difficult or even impossible to conduct. The prognosis capability is demonstrated here via a balloon burst experiment where the instability is predicted using only online visual observations. The DDP scheme never failed to predict the incipient failure, and no false-positives were issued. The DDP algorithm is applicable to other types of datasets. Time horizons of DDP predictions can be adjusted by using memory over different time windows. Thus, a big dataset can be parsed in time to make a range of predictions over varying time horizons.

Development and Testing of a Shape Memory Alloy-Driven Composite Morphing Radiator

NASA Astrophysics Data System (ADS)

Walgren, P.; Bertagne, C.; Wescott, M.; Benafan, O.; Erickson, L.; Whitcomb, J.; Hartl, D.

2018-03-01

Future crewed deep space missions will require thermal control systems that can accommodate larger fluctuations in temperature and heat rejection loads than current designs. To maintain the crew cabin at habitable temperatures throughout the entire mission profile, radiators will be required to exhibit turndown ratios (defined as the ratio between the maximum and minimum heat rejection rates) as high as 12:1. Potential solutions to increase radiator turndown ratios include designs that vary the heat rejection rate by changing shape, hence changing the rate of radiation to space. Shape memory alloys exhibit thermally driven phase transformations and thus can be used for both the control and actuation of such a morphing radiator with a single active structural component that transduces thermal energy into motion. This work focuses on designing a high-performance composite radiator panel and investigating the behavior of various SMA actuators in this application. Three designs were fabricated and subsequently tested in a relevant thermal vacuum environment; all three exhibited repeatable morphing behavior, and it is shown through validated computational analysis that the morphing radiator concept can achieve a turndown ratio of 27:1 with a number of simple configuration changes.

Bending strength of delaminated aerospace composites.

PubMed

Kinawy, Moustafa; Butler, Richard; Hunt, Giles W

2012-04-28

Buckling-driven delamination is considered among the most critical failure modes in composite laminates. This paper examines the propagation of delaminations in a beam under pure bending. A pre-developed analytical model to predict the critical buckling moment of a thin sub-laminate is extended to account for propagation prediction, using mixed-mode fracture analysis. Fractography analysis is performed to distinguish between mode I and mode II contributions to the final failure of specimens. Comparison between experimental results and analysis shows agreement to within 5 per cent in static propagation moment for two different materials. It is concluded that static fracture is almost entirely driven by mode II effects. This result was unexpected because it arises from a buckling mode that opens the delamination. For this reason, and because of the excellent repeatability of the experiments, the method of testing may be a promising means of establishing the critical value of mode II fracture toughness, G(IIC), of the material. Fatigue testing on similar samples showed that buckled delamination resulted in a fatigue threshold that was over 80 per cent lower than the static propagation moment. Such an outcome highlights the significance of predicting snap-buckling moment and subsequent propagation for design purposes.

High performance cellular level agent-based simulation with FLAME for the GPU.

PubMed

Richmond, Paul; Walker, Dawn; Coakley, Simon; Romano, Daniela

2010-05-01

Driven by the availability of experimental data and ability to simulate a biological scale which is of immediate interest, the cellular scale is fast emerging as an ideal candidate for middle-out modelling. As with 'bottom-up' simulation approaches, cellular level simulations demand a high degree of computational power, which in large-scale simulations can only be achieved through parallel computing. The flexible large-scale agent modelling environment (FLAME) is a template driven framework for agent-based modelling (ABM) on parallel architectures ideally suited to the simulation of cellular systems. It is available for both high performance computing clusters (www.flame.ac.uk) and GPU hardware (www.flamegpu.com) and uses a formal specification technique that acts as a universal modelling format. This not only creates an abstraction from the underlying hardware architectures, but avoids the steep learning curve associated with programming them. In benchmarking tests and simulations of advanced cellular systems, FLAME GPU has reported massive improvement in performance over more traditional ABM frameworks. This allows the time spent in the development and testing stages of modelling to be drastically reduced and creates the possibility of real-time visualisation for simple visual face-validation.

Microwave-Driven Multifunctional Capability of Membrane Structures

NASA Technical Reports Server (NTRS)

Choi, Sang H.; Chu, Sang-Hyong; Song, Kyo D.; King, Glen C.

2002-01-01

A large, ultra lightweight space structure, such as solar sails and Gossamer spacecrafts, requires a distributed power source to alleviate wire networks, unlike the localized on-board power infrastructures typically found in most small spacecrafts. The concept of microwave-driven multifunctional capability for membrane structures is envisioned as the best option to alleviate the complexity associated with hard-wired control circuitry and on-board power infrastructures. A rectenna array based on a patch configuration for high voltage output was developed to drive membrane actuators, sensors, probes, or other devices. Networked patch rectenna array receives and converts microwave power into a DC power for an array of smart actuators. To use microwave power effectively, the concept of a power allocation and distribution (PAD) circuit is adopted for networking a rectenna/actuator patch array. The use of patch rectennas adds a significant amount of rigidity to membrane flexibility and they are relatively heavy. A dipole rectenna array (DRA) appears to be ideal for thin-film membrane structures, since DRA is flexible and light. Preliminary design and fabrication of PAD circuitry that consists of a few nodal elements were made for laboratory testing. The networked actuators were tested to correlate the network coupling effect, power allocation and distribution, and response time.

Dynamics of gas-driven eruptions: Experimental simulations using CO2-H2O-polymer system

NASA Astrophysics Data System (ADS)

Zhang, Youxue; Sturtevant, B.; Stolper, E. M.

1997-02-01

We report exploratory experiments simulating gas-driven eruptions using the CO2-H2O system at room temperature as an analog of natural eruptive systems. The experimental apparatus consists of a test cell and a large tank. Initially, up to 1.0 wt% of CO2 is dissolved in liquid water under a pressure of up to 735 kPa in the test cell. The experiment is initiated by suddenly reducing the pressure of the test cell to a typical tank pressure of 10 kPa. The following are the main results: (1) The style of the process depends on the decompression ratio. There is a threshold decompression ratio above which rapid eruption occurs. (2) During rapid eruption, there is always fragmentation at the liquid-vapor interface. Fragmentation may also occur in the flow interior. (3) Initially, the top of the erupting column ascends at a constant acceleration (instead of constant velocity). (4) Average bubble radius grows as t2/3. (5) When viscosity is 20 times that of pure water or greater, a static foam may be stable after expansion to 97% vesicularity. The experiments provide several insights into natural gas-driven eruptions, including (1) the interplay between bubble growth and ascent of the erupting column must be considered for realistic modeling of bubble growth during gas-driven eruptions, (2) buoyant rise of the bubbly magma is not necessary during an explosive volcanic eruption, and (3) CO2-driven limnic eruptions can be explosive. The violence increases with the initial CO2 content dissolved in water.

Experiences in Teaching a Graduate Course on Model-Driven Software Development

ERIC Educational Resources Information Center

Tekinerdogan, Bedir

2011-01-01

Model-driven software development (MDSD) aims to support the development and evolution of software intensive systems using the basic concepts of model, metamodel, and model transformation. In parallel with the ongoing academic research, MDSD is more and more applied in industrial practices. After being accepted both by a broad community of…

On the Value-Dependence of Value-Driven Attentional Capture

PubMed Central

Anderson, Brian A.; Halpern, Madeline

2017-01-01

Findings from an increasingly large number of studies have been used to argue that attentional capture can be dependent on the learned value of a stimulus, or value-driven. However, under certain circumstances attention can be biased to select stimuli that previously served as targets, independent of reward history. Value-driven attentional capture, as studied using the training phase-test phase design introduced by Anderson and colleagues, is widely presumed to reflect the combined influence of learned value and selection history. However, the degree to which attentional capture is at all dependent on value learning in this paradigm has recently been questioned. Support for value-dependence can be provided through one of two means: (1) greater attentional capture by prior targets following rewarded training than following unrewarded training, and (2) greater attentional capture by prior targets previously associated with high compared to low value. Using a variant of the original value-driven attentional capture paradigm, Sha and Jiang (2016) failed to find evidence of either, and raised criticisms regarding the adequacy of evidence provided by prior studies using this particular paradigm. To address this disparity, here we provided a stringent test of the value-dependence hypothesis using the traditional value-driven attentional capture paradigm. With a sufficiently large sample size, value-dependence was observed based on both criteria, with no evidence of attentional capture without rewards during training. Our findings support the validity of the traditional value-driven attentional capture paradigm in measuring what its name purports to measure. PMID:28176215

Capillary zone electrophoresis method for a highly glycosylated and sialylated recombinant protein: development, characterization and application for process development.

PubMed

Zhang, Le; Lawson, Ken; Yeung, Bernice; Wypych, Jette

2015-01-06

A purity method based on capillary zone electrophoresis (CZE) has been developed for the separation of isoforms of a highly glycosylated protein. The separation was found to be driven by the number of sialic acids attached to each isoform. The method has been characterized using orthogonal assays and shown to have excellent specificity, precision and accuracy. We have demonstrated the CZE method is a useful in-process assay to support cell culture and purification development of this glycoprotein. Compared to isoelectric focusing (IEF), the CZE method provides more quantitative results and higher sample throughput with excellent accuracy, qualities that are required for process development. In addition, the CZE method has been applied in the stability testing of purified glycoprotein samples.

Commercialization of an S-band standing-wave electron accelerator for industrial applications

NASA Astrophysics Data System (ADS)

Moon, Jin-Hyeok; Kwak, Gyeong-Il; Han, Jae-Ik; Lee, Gyu-Baek; Jeon, Seong-Hwan; Kim, Jae-Young; Hwang, Cheol-Bin; Lee, Gi-Yong; Kim, Young-Man; Park, Sung-Ju

2016-09-01

An electron accelerator system has been developed for use in industrial, as well as possible medical, applications. Based on our experiences achieved during prototype system development and various electron beam acceleration tests, we have built a stable and compact system for sales purposes. We have integrated a self-developed accelerating cavity, an E-gun pulse driver, a radio-frequency (RF) power system, a vacuum system, a cooling system, etc. into a frame with a size of 1800 × 1000 × 1500 mm3. The accelerating structure is a side-coupled standing-wave type operating in the π/2 mode (tuned to~3 GHz). The RF power is provided by using a magnetron driven by a solid-state modulator. The electron gun is a triode type with a dispenser cathode (diameter of 11 mm). The system is capable of delivering a maximum 900-W average electron beam power with tight focusing at the target. Until now, we have performed various electron beam tests and X-ray beam tests after having built the system, have completed the beam assessment for commercializations, and have been preparing full-fledged sales activity. This article reports on our system development processes and on some of our early test results for commercializations.

A data driven method for estimation of B(avail) and appK(D) using a single injection protocol with [¹¹C]raclopride in the mouse.

PubMed

Wimberley, Catriona J; Fischer, Kristina; Reilhac, Anthonin; Pichler, Bernd J; Gregoire, Marie Claude

2014-10-01

The partial saturation approach (PSA) is a simple, single injection experimental protocol that will estimate both B(avail) and appK(D) without the use of blood sampling. This makes it ideal for use in longitudinal studies of neurodegenerative diseases in the rodent. The aim of this study was to increase the range and applicability of the PSA by developing a data driven strategy for determining reliable regional estimates of receptor density (B(avail)) and in vivo affinity (1/appK(D)), and validate the strategy using a simulation model. The data driven method uses a time window guided by the dynamic equilibrium state of the system as opposed to using a static time window. To test the method, simulations of partial saturation experiments were generated and validated against experimental data. The experimental conditions simulated included a range of receptor occupancy levels and three different B(avail) and appK(D) values to mimic diseases states. Also the effect of using a reference region and typical PET noise on the stability and accuracy of the estimates was investigated. The investigations showed that the parameter estimates in a simulated healthy mouse, using the data driven method were within 10±30% of the simulated input for the range of occupancy levels simulated. Throughout all experimental conditions simulated, the accuracy and robustness of the estimates using the data driven method were much improved upon the typical method of using a static time window, especially at low receptor occupancy levels. Introducing a reference region caused a bias of approximately 10% over the range of occupancy levels. Based on extensive simulated experimental conditions, it was shown the data driven method provides accurate and precise estimates of B(avail) and appK(D) for a broader range of conditions compared to the original method. Copyright © 2014 Elsevier Inc. All rights reserved.

Modeling of fast neutral-beam-generated ions and rotation effects on RWM stability in DIII-D plasmas

DOE PAGES

Turco, Francesca; Turnbull, Alan D.; Hanson, Jeremy M.; ...

2015-10-15

Here, validation results for the MARS-K code for DIII-D equilibria, predict that the absence of fast Neutral Beam (NB) generated ions leads to a plasma response ~40–60% higher than in NB-sustained H-mode plasmas when the no-wall β N limit is reached. In a β N scan, the MARS-K model with thermal and fast-ions, reproduces the experimental measurements above the no-wall limit, except at the highest β N where the phase of the plasma response is overestimated. The dependencies extrapolate unfavorably to machines such as ITER with smaller fast ion fractions since elevated responses in the absence of fast ions indicatemore » the potential onset of a resistive wall mode (RWM). The model was also tested for the effects of rotation at high β N, and recovers the measured response even when fast-ions are neglected, reversing the effect found in lower β N cases, but consistent with the higher β N results above the no-wall limit. The agreement in the response amplitude and phase for the rotation scan is not as good, and additional work will be needed to reproduce the experimental trends. In the case of current-driven instabilities, the magnetohydrodynamic spectroscopy system used to measure the plasma response reacts differently from that for pressure driven instabilities: the response amplitude remains low up to ~93% of the current limit, showing an abrupt increase only in the last ~5% of the current ramp. This makes it much less effective as a diagnostic for the approach to an ideal limit. However, the mode structure of the current driven RWM extends radially inwards, consistent with that in the pressure driven case for plasmas with q edge~2. This suggests that previously developed RWM feedback techniques together with the additional optimizations that enabled q edge~2 operation, can be applied to control of both current-driven and pressure-driven modes at high β N.« less

HIV testing among immigrant sexual and gender minority Latinos in a US region with little historical Latino presence.

PubMed

Gilbert, Paul A; Rhodes, Scott D

2013-11-01

Immigrant sexual and gender minority Latinos constitute a vulnerable subgroup about which little is known. We examined HIV testing among 190 such Latinos recruited via respondent-driven sampling in North Carolina, a state with little historical Latino presence but recent, rapid growth of this population. Sixty-eight percent reported an HIV test in the past year, and nearly half reported multiple HIV tests. Concern for their health was the most frequent reason for seeking an HIV test. Reasons not to get tested included fear of a positive test, previous HIV tests, worry that test results might be reported to the government, and concerns that others might treat the person differently if found to be HIV positive. In a multiple variable model, correlates of HIV testing included age, educational attainment, HIV stigma, comfort with sexual orientation, and previous STD diagnoses. Among participants reporting anal sex, consistent condom use was associated with HIV testing, suggesting that protective behaviors may co-occur. These findings may inform the development of more efficacious interventions to increase HIV testing among this subgroup.

HIV Testing Among Immigrant Sexual and Gender Minority Latinos in a US Region with Little Historical Latino Presence

PubMed Central

Rhodes, Scott D.

2013-01-01

Abstract Immigrant sexual and gender minority Latinos constitute a vulnerable subgroup about which little is known. We examined HIV testing among 190 such Latinos recruited via respondent-driven sampling in North Carolina, a state with little historical Latino presence but recent, rapid growth of this population. Sixty-eight percent reported an HIV test in the past year, and nearly half reported multiple HIV tests. Concern for their health was the most frequent reason for seeking an HIV test. Reasons not to get tested included fear of a positive test, previous HIV tests, worry that test results might be reported to the government, and concerns that others might treat the person differently if found to be HIV positive. In a multiple variable model, correlates of HIV testing included age, educational attainment, HIV stigma, comfort with sexual orientation, and previous STD diagnoses. Among participants reporting anal sex, consistent condom use was associated with HIV testing, suggesting that protective behaviors may co-occur. These findings may inform the development of more efficacious interventions to increase HIV testing among this subgroup. PMID:24138487

Proteomic Approaches to Enable Point-of-Care Testing and Personalized Medicine for Psychiatric Disorders.

PubMed

Guest, Francesca L; Guest, Paul C

2017-01-01

This chapter describes how innovations that are driven by proteomic biomarker techniques can facilitate earlier and better treatment of patients who suffer from psychiatric disorders. The application of new micro-fluidic devices along with miniaturized biosensors and transducers will enable the development of handheld point-of-care testing instruments which can analyse a drop of a blood within the time span of a single visit to the doctor's office. It is anticipated that these approaches will incorporate both biochemical and clinical information, resulting in unique profiles for each test subject. These profiles can in turn be used to drive personalized medicine approaches in this devastating disease area. In addition, smartphone applications (apps) for self-monitoring will see increasing use for improved patient outcomes.

Plans and Preliminary Results of Fundamental Studies of Ice Crystal Icing Physics in the NASA Propulsion Systems Laboratory

NASA Technical Reports Server (NTRS)

Struk, Peter; Tsao, Jen-Ching; Bartkus, Tadas

2017-01-01

This paper describes plans and preliminary results for using the NASA Propulsion Systems Lab (PSL) to experimentally study the fundamental physics of ice-crystal ice accretion. NASA is evaluating whether this facility, in addition to full-engine and motor-driven-rig tests, can be used for more fundamental ice-accretion studies that simulate the different mixed-phase icing conditions along the core flow passage of a turbo-fan engine compressor. The data from such fundamental accretion tests will be used to help develop and validate models of the accretion process. This paper presents data from some preliminary testing performed in May 2015 which examined how a mixed-phase cloud could be generated at PSL using evaporative cooling in a warmer-than-freezing environment.

Plans and Preliminary Results of Fundamental Studies of Ice Crystal Icing Physics in the NASA Propulsion Systems Laboratory

NASA Technical Reports Server (NTRS)

Struk, Peter; Tsao, Jen-Ching; Bartkus, Tadas

2016-01-01

This presentation accompanies the paper titled Plans and Preliminary Results of Fundamental Studies of Ice Crystal Icing Physics in the NASA Propulsion Systems Laboratory. NASA is evaluating whether PSL, in addition to full-engine and motor-driven-rig tests, can be used for more fundamental ice-accretion studies that simulate the different mixed-phase icing conditions along the core flow passage of a turbo-fan engine compressor. The data from such fundamental accretion tests will be used to help develop and validate models of the accretion process. This presentation (and accompanying paper) presents data from some preliminary testing performed in May 2015 which examined how a mixed-phase cloud could be generated at PSL using evaporative cooling in a warmer-than-freezing environment.

Purpose-Driven Leadership: The Spiritual Imperative to Guiding Schools beyond High-Stakes Testing and Minimum Proficiency.

ERIC Educational Resources Information Center

Dantley, Michael E.

2003-01-01

Examines purposeful leadership, a concept grounded in "prophetic spirituality." Suggests that educational leaders who build their professional practice in purpose-driven leadership clearly understand the multidimensional aspects of their daily challenges yet find the inner strength to resist hegemonic structures and forms of oppression and…

Resistance factors for 100% dynamic testing, with and without static load tests.

DOT National Transportation Integrated Search

2011-05-01

Current department of transportation (DOT) and Federal Highway Administration (FHWA) practice has highly : variable load and resistance factor design (LRFD) resistance factors, , for driven piles from design (e.g., Standard : Penetration Tests (SPT...

Singing-driven gene expression in the developing songbird brain

PubMed Central

Johnson, Frank; Whitney, Osceola

2014-01-01

Neural and behavioral development arises from an integration of genetic and environmental influences, yet specifying the nature of this interaction remains a primary problem in neuroscience. Here, we review molecular and behavioral studies that focus on the role of singing-driven gene expression during neural and vocal development in the male zebra finch (Taeniopygia guttata), a songbird that learns a species-typical vocal pattern during juvenile development by imitating an adult male tutor. A primary aim of our lab has been to identify naturally-occurring environmental influences that shape the propensity to sing. This ethological approach underlies our theoretical perspective, which is to integrate the significance of singing-driven gene expression into a broader ecological context. PMID:16129463

Fast-Cycle Curriculum Development Strategies for E-Business Programs: The Bentley College Experience.

ERIC Educational Resources Information Center

Fedorowicz, Jane; Gogan, Janis L.

2001-01-01

Presents two types of fast-cycle curriculum development processes: research driven and stakeholder driven. Illustrates their application in the Bentley College business school's new course modules, elective courses, and graduate program on electronic commerce. (Contains 19 references.) (SK)

Quantitative Accelerated Life Testing of MEMS Accelerometers

PubMed Central

Bâzu, Marius; Gălăţeanu, Lucian; Ilian, Virgil Emil; Loicq, Jerome; Habraken, Serge; Collette, Jean-Paul

2007-01-01

Quantitative Accelerated Life Testing (QALT) is a solution for assessing the reliability of Micro Electro Mechanical Systems (MEMS). A procedure for QALT is shown in this paper and an attempt to assess the reliability level for a batch of MEMS accelerometers is reported. The testing plan is application-driven and contains combined tests: thermal (high temperature) and mechanical stress. Two variants of mechanical stress are used: vibration (at a fixed frequency) and tilting. Original equipment for testing at tilting and high temperature is used. Tilting is appropriate as application-driven stress, because the tilt movement is a natural environment for devices used for automotive and aerospace applications. Also, tilting is used by MEMS accelerometers for anti-theft systems. The test results demonstrated the excellent reliability of the studied devices, the failure rate in the “worst case” being smaller than 10-7h-1. PMID:28903265

Scramjet test flow reconstruction for a large-scale expansion tube, Part 1: quasi-one-dimensional modelling

NASA Astrophysics Data System (ADS)

Gildfind, D. E.; Jacobs, P. A.; Morgan, R. G.; Chan, W. Y. K.; Gollan, R. J.

2018-07-01

Large-scale free-piston driven expansion tubes have uniquely high total pressure capabilities which make them an important resource for development of access-to-space scramjet engine technology. However, many aspects of their operation are complex, and their test flows are fundamentally unsteady and difficult to measure. While computational fluid dynamics methods provide an important tool for quantifying these flows, these calculations become very expensive with increasing facility size and therefore have to be carefully constructed to ensure sufficient accuracy is achieved within feasible computational times. This study examines modelling strategies for a Mach 10 scramjet test condition developed for The University of Queensland's X3 facility. The present paper outlines the challenges associated with test flow reconstruction, describes the experimental set-up for the X3 experiments, and then details the development of an experimentally tuned quasi-one-dimensional CFD model of the full facility. The 1-D model, which accurately captures longitudinal wave processes, is used to calculate the transient flow history in the shock tube. This becomes the inflow to a higher-fidelity 2-D axisymmetric simulation of the downstream facility, detailed in the Part 2 companion paper, leading to a validated, fully defined nozzle exit test flow.

Scramjet test flow reconstruction for a large-scale expansion tube, Part 1: quasi-one-dimensional modelling

NASA Astrophysics Data System (ADS)

Gildfind, D. E.; Jacobs, P. A.; Morgan, R. G.; Chan, W. Y. K.; Gollan, R. J.

2017-11-01

Large-scale free-piston driven expansion tubes have uniquely high total pressure capabilities which make them an important resource for development of access-to-space scramjet engine technology. However, many aspects of their operation are complex, and their test flows are fundamentally unsteady and difficult to measure. While computational fluid dynamics methods provide an important tool for quantifying these flows, these calculations become very expensive with increasing facility size and therefore have to be carefully constructed to ensure sufficient accuracy is achieved within feasible computational times. This study examines modelling strategies for a Mach 10 scramjet test condition developed for The University of Queensland's X3 facility. The present paper outlines the challenges associated with test flow reconstruction, describes the experimental set-up for the X3 experiments, and then details the development of an experimentally tuned quasi-one-dimensional CFD model of the full facility. The 1-D model, which accurately captures longitudinal wave processes, is used to calculate the transient flow history in the shock tube. This becomes the inflow to a higher-fidelity 2-D axisymmetric simulation of the downstream facility, detailed in the Part 2 companion paper, leading to a validated, fully defined nozzle exit test flow.

Pure moment testing for spinal biomechanics applications: fixed versus 3D floating ring cable-driven test designs.

PubMed

Tang, Jessica A; Scheer, Justin K; Ames, Christopher P; Buckley, Jenni M

2012-02-23

Pure moment testing has become a standard protocol for in vitro assessment of the effect of surgical techniques or devices on the bending rigidity of the spine. Of the methods used for pure moment testing, cable-driven set-ups are popular due to their low requirements and simple design. Fixed loading rings are traditionally used in conjunction with these cable-driven systems. However, the accuracy and validity of the loading conditions applied with fixed ring designs have raised some concern, and discrepancies have been found between intended and prescribed loading conditions for flexion-extension. This study extends this prior work to include lateral bending and axial torsion, and compares this fixed ring design with a novel "3D floating ring" design. A complete battery of multi-axial bending tests was conducted with both rings in multiple different configurations using an artificial lumbar spine. Applied moments were monitored and recorded by a multi-axial load cell at the base of the specimen. Results indicate that the fixed ring design deviates as much as 77% from intended moments and induces non-trivial shear forces (up to 18 N) when loaded to a non-destructive maximum of 4.5 Nm. The novel 3D floating ring design largely corrects the inherent errors in the fixed ring design by allowing additional directions of unconstrained motion and producing uniform loading conditions along the length of the specimen. In light of the results, it is suggested that the 3D floating ring set-up be used for future pure moment spine biomechanics applications using a cable-driven apparatus. Copyright © 2012 Elsevier Ltd. All rights reserved.

Numerical Simulation of the Emergency Condenser of the SWR-1000

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krepper, Eckhard; Schaffrath, Andreas; Aszodi, Attila

The SWR-1000 is a new innovative boiling water reactor (BWR) concept, which was developed by Siemens AG. This concept is characterized in particular by passive safety systems (e.g., four emergency condensers, four building condensers, eight passive pressure pulse transmitters, and six gravity-driven core-flooding lines). In the framework of the BWR Physics and Thermohydraulic Complementary Action to the European Union BWR Research and Development Cluster, emergency condenser tests were performed by Forschungszentrum Juelich at the NOKO test facility. Posttest calculations with ATHLET are presented, which aim at the determination of the removable power of the emergency condenser and its operation mode.more » The one-dimensional thermal-hydraulic code ATHLET was extended by the module KONWAR for the calculation of the heat transfer coefficient during condensation in horizontal tubes. In addition, results of conventional finite difference calculations using the code CFX-4 are presented, which investigate the natural convection during the heatup process at the secondary side of the NOKO test facility.« less

Hollow Fiber Ground Evaporator Unit Testing

NASA Technical Reports Server (NTRS)

Bue, Grant; Trevino, Luis; Tsioulos, Gus

2010-01-01

A candidate technology for 1-atmosphere suited heat rejection was developed and tested at NASA Johnson Space Center. The concept is to use a collection of microporous hydrophobic tubes potted between inlet and outlet headers with water as coolant. A pump provides flow between headers through the tubes which are subjected to fan driven cross flow of relatively dry air. The forced ventilation would sweep out the water vapor from the evaporation of the coolant rejecting heat from the coolant stream. The hollow fibers are obtained commercially (X50-215 Celgard) which are arranged in a sheet containing 5 fibers per linear inch. Two engineering development units were produced that vary the fold direction of the fiber sheets relative to the ventilation. These units were tested at inlet water temperatures ranging from 20 deg C to 30 deg C, coolant flow rates ranging from 10 to 90 kg/hr, and at three fan speeds. These results were used to size a system that could reject heat at a rate of 340 W.

A Resonant Pulse Detonation Actuator for High-Speed Boundary Layer Separation Control

NASA Technical Reports Server (NTRS)

Beck, B. T.; Cutler, A. D.; Drummond, J. P.; Jones, S. B.

2004-01-01

A variety of different types of actuators have been previously investigated as flow control devices. Potential applications include the control of boundary layer separation in external flows, as well as jet engine inlet and diffuser flow control. The operating principles for such devices are typically based on either mechanical deflection of control surfaces (which include MEMS flap devices), mass injection (which includes combustion driven jet actuators), or through the use of synthetic jets (diaphragm devices which produce a pulsating jet with no net mass flow). This paper introduces some of the initial flow visualization work related to the development of a relatively new type of combustion-driven jet actuator that has been proposed based on a pulse detonation principle. The device is designed to utilize localized detonation of a premixed fuel (Hydrogen)-air mixture to periodically inject a jet of gas transversely into the primary flow. Initial testing with airflow successfully demonstrated resonant conditions within the range of acoustic frequencies expected for the design. Schlieren visualization of the pulsating air jet structure revealed axially symmetric vortex flow, along with the formation of shocks. Flow visualization of the first successful sustained oscillation condition is also demonstrated for one configuration of the current test section. Future testing will explore in more detail the onset of resonant combustion and the approach to conditions of sustained resonant detonation.

Toward a user-driven approach to radiology software solutions: putting the wag back in the dog.

PubMed

Morgan, Matthew; Mates, Jonathan; Chang, Paul

2006-09-01

The relationship between healthcare providers and the software industry is evolving. In many cases, industry's traditional, market-driven model is failing to meet the increasingly sophisticated and appropriately individualized needs of providers. Advances in both technology infrastructure and development methodologies have set the stage for the transition from a vendor-driven to a more user-driven process of solution engineering. To make this transition, providers must take an active role in the development process and vendors must provide flexible frameworks on which to build. Only then can the provider/vendor relationship mature from a purchaser/supplier to a codesigner/partner model, where true insight and innovation can occur.

Closed-form solutions in stress-driven two-phase integral elasticity for bending of functionally graded nano-beams

NASA Astrophysics Data System (ADS)

Barretta, Raffaele; Fabbrocino, Francesco; Luciano, Raimondo; Sciarra, Francesco Marotti de

2018-03-01

Strain-driven and stress-driven integral elasticity models are formulated for the analysis of the structural behaviour of fuctionally graded nano-beams. An innovative stress-driven two-phases constitutive mixture defined by a convex combination of local and nonlocal phases is presented. The analysis reveals that the Eringen strain-driven fully nonlocal model cannot be used in Structural Mechanics since it is ill-posed and the local-nonlocal mixtures based on the Eringen integral model partially resolve the ill-posedeness of the model. In fact, a singular behaviour of continuous nano-structures appears if the local fraction tends to vanish so that the ill-posedness of the Eringen integral model is not eliminated. On the contrary, local-nonlocal mixtures based on the stress-driven theory are mathematically and mechanically appropriate for nanosystems. Exact solutions of inflected functionally graded nanobeams of technical interest are established by adopting the new local-nonlocal mixture stress-driven integral relation. Effectiveness of the new nonlocal approach is tested by comparing the contributed results with the ones corresponding to the mixture Eringen theory.

Investigation of periodically driven systems by x-ray absorption spectroscopy using asynchronous data collection mode

NASA Astrophysics Data System (ADS)

Singh, H.; Donetsky, D.; Liu, J.; Attenkofer, K.; Cheng, B.; Trelewicz, J. R.; Lubomirsky, I.; Stavitski, E.; Frenkel, A. I.

2018-04-01

We report the development, testing, and demonstration of a setup for modulation excitation spectroscopy experiments at the Inner Shell Spectroscopy beamline of National Synchrotron Light Source - II. A computer algorithm and dedicated software were developed for asynchronous data processing and analysis. We demonstrate the reconstruction of X-ray absorption spectra for different time points within the modulation pulse using a model system. This setup and the software are intended for a broad range of functional materials which exhibit structural and/or electronic responses to the external stimulation, such as catalysts, energy and battery materials, and electromechanical devices.

From theory to practice: community health nursing in a public health neighborhood team.

PubMed

Westbrook, L O; Schultz, P R

2000-12-01

An interdisciplinary team in a local public health district tested its ability to implement the core public health functions of assessment, policy development, and assurance by changing its practice to a community-driven model of building partnerships for health with groups and communities in a designated locale. Evaluation of this innovation revealed that the public health nurse members of the team enacted their community health nursing knowledge to strengthen agency to cocreate health. Interdisciplinary collaboration was essential to the team's community mobilization efforts. Additional findings suggested that this organizational innovation was associated with developing a more participatory organizational climate, increasing system effectiveness, and building community capacity.

Traditional Medicine Collection Tracking System (TM-CTS): a database for ethnobotanically driven drug-discovery programs.

PubMed

Harris, Eric S J; Erickson, Sean D; Tolopko, Andrew N; Cao, Shugeng; Craycroft, Jane A; Scholten, Robert; Fu, Yanling; Wang, Wenquan; Liu, Yong; Zhao, Zhongzhen; Clardy, Jon; Shamu, Caroline E; Eisenberg, David M

2011-05-17

Ethnobotanically driven drug-discovery programs include data related to many aspects of the preparation of botanical medicines, from initial plant collection to chemical extraction and fractionation. The Traditional Medicine Collection Tracking System (TM-CTS) was created to organize and store data of this type for an international collaborative project involving the systematic evaluation of commonly used Traditional Chinese Medicinal plants. The system was developed using domain-driven design techniques, and is implemented using Java, Hibernate, PostgreSQL, Business Intelligence and Reporting Tools (BIRT), and Apache Tomcat. The TM-CTS relational database schema contains over 70 data types, comprising over 500 data fields. The system incorporates a number of unique features that are useful in the context of ethnobotanical projects such as support for information about botanical collection, method of processing, quality tests for plants with existing pharmacopoeia standards, chemical extraction and fractionation, and historical uses of the plants. The database also accommodates data provided in multiple languages and integration with a database system built to support high throughput screening based drug discovery efforts. It is accessed via a web-based application that provides extensive, multi-format reporting capabilities. This new database system was designed to support a project evaluating the bioactivity of Chinese medicinal plants. The software used to create the database is open source, freely available, and could potentially be applied to other ethnobotanically driven natural product collection and drug-discovery programs. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Traditional Medicine Collection Tracking System (TM-CTS): A Database for Ethnobotanically-Driven Drug-Discovery Programs

PubMed Central

Harris, Eric S. J.; Erickson, Sean D.; Tolopko, Andrew N.; Cao, Shugeng; Craycroft, Jane A.; Scholten, Robert; Fu, Yanling; Wang, Wenquan; Liu, Yong; Zhao, Zhongzhen; Clardy, Jon; Shamu, Caroline E.; Eisenberg, David M.

2011-01-01

Aim of the study. Ethnobotanically-driven drug-discovery programs include data related to many aspects of the preparation of botanical medicines, from initial plant collection to chemical extraction and fractionation. The Traditional Medicine-Collection Tracking System (TM-CTS) was created to organize and store data of this type for an international collaborative project involving the systematic evaluation of commonly used Traditional Chinese Medicinal plants. Materials and Methods. The system was developed using domain-driven design techniques, and is implemented using Java, Hibernate, PostgreSQL, Business Intelligence and Reporting Tools (BIRT), and Apache Tomcat. Results. The TM-CTS relational database schema contains over 70 data types, comprising over 500 data fields. The system incorporates a number of unique features that are useful in the context of ethnobotanical projects such as support for information about botanical collection, method of processing, quality tests for plants with existing pharmacopoeia standards, chemical extraction and fractionation, and historical uses of the plants. The database also accommodates data provided in multiple languages and integration with a database system built to support high throughput screening based drug discovery efforts. It is accessed via a web-based application that provides extensive, multi-format reporting capabilities. Conclusions. This new database system was designed to support a project evaluating the bioactivity of Chinese medicinal plants. The software used to create the database is open source, freely available, and could potentially be applied to other ethnobotanically-driven natural product collection and drug-discovery programs. PMID:21420479

Flight-Test Evaluation of Flutter-Prediction Methods

NASA Technical Reports Server (NTRS)

Lind, RIck; Brenner, Marty

2003-01-01

The flight-test community routinely spends considerable time and money to determine a range of flight conditions, called a flight envelope, within which an aircraft is safe to fly. The cost of determining a flight envelope could be greatly reduced if there were a method of safely and accurately predicting the speed associated with the onset of an instability called flutter. Several methods have been developed with the goal of predicting flutter speeds to improve the efficiency of flight testing. These methods include (1) data-based methods, in which one relies entirely on information obtained from the flight tests and (2) model-based approaches, in which one relies on a combination of flight data and theoretical models. The data-driven methods include one based on extrapolation of damping trends, one that involves an envelope function, one that involves the Zimmerman-Weissenburger flutter margin, and one that involves a discrete-time auto-regressive model. An example of a model-based approach is that of the flutterometer. These methods have all been shown to be theoretically valid and have been demonstrated on simple test cases; however, until now, they have not been thoroughly evaluated in flight tests. An experimental apparatus called the Aerostructures Test Wing (ATW) was developed to test these prediction methods.

Optical components damage parameters database system

NASA Astrophysics Data System (ADS)

Tao, Yizheng; Li, Xinglan; Jin, Yuquan; Xie, Dongmei; Tang, Dingyong

2012-10-01

Optical component is the key to large-scale laser device developed by one of its load capacity is directly related to the device output capacity indicators, load capacity depends on many factors. Through the optical components will damage parameters database load capacity factors of various digital, information technology, for the load capacity of optical components to provide a scientific basis for data support; use of business processes and model-driven approach, the establishment of component damage parameter information model and database systems, system application results that meet the injury test optical components business processes and data management requirements of damage parameters, component parameters of flexible, configurable system is simple, easy to use, improve the efficiency of the optical component damage test.

40 CFR 86.427-78 - Emission tests.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 19 2012-07-01 2012-07-01 false Emission tests. 86.427-78 Section 86... Later New Motorcycles, General Provisions § 86.427-78 Emission tests. (a)(1) Each test vehicle shall be driven with all emission control systems installed and operating for the following total test distances...

40 CFR 86.427-78 - Emission tests.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 19 2014-07-01 2014-07-01 false Emission tests. 86.427-78 Section 86... Later New Motorcycles, General Provisions § 86.427-78 Emission tests. (a)(1) Each test vehicle shall be driven with all emission control systems installed and operating for the following total test distances...

40 CFR 86.427-78 - Emission tests.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 19 2013-07-01 2013-07-01 false Emission tests. 86.427-78 Section 86... Later New Motorcycles, General Provisions § 86.427-78 Emission tests. (a)(1) Each test vehicle shall be driven with all emission control systems installed and operating for the following total test distances...

30 CFR 18.62 - Tests to determine explosion-proof characteristics.

Code of Federal Regulations, 2010 CFR

2010-07-01

... TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES... be varied. Motor armatures and/or rotors will be stationary in some tests and revolving in others... electrical components during some of the tests. Not less than 16 explosion tests shall be conducted; however...

An miRNA-mediated therapy for SCA6 blocks IRES-driven translation of the CACNA1A second cistron.

PubMed

Miyazaki, Yu; Du, Xiaofei; Muramatsu, Shin-Ichi; Gomez, Christopher M

2016-07-13

Spinocerebellar ataxia type 6 (SCA6) is a dominantly inherited neurodegenerative disease characterized by slowly progressive ataxia and Purkinje cell degeneration. SCA6 is caused by a polyglutamine repeat expansion within a second CACNA1A gene product, α1ACT. α1ACT expression is under the control of an internal ribosomal entry site (IRES) present within the CACNA1A coding region. Whereas SCA6 allele knock-in mice show indistinguishable phenotypes from wild-type littermates, expression of SCA6-associated α1ACT (α1ACTSCA6) driven by a Purkinje cell-specific promoter in mice produces slowly progressive ataxia and cerebellar atrophy. We developed an early-onset SCA6 mouse model using an adeno-associated virus (AAV)-based gene delivery system to ectopically express CACNA1A IRES-driven α1ACTSCA6 to test the potential of CACNA1A IRES-targeting therapies. Mice expressing AAV9-mediated CACNA1A IRES-driven α1ACTSCA6 exhibited early-onset ataxia, motor deficits, and Purkinje cell degeneration. We identified miR-3191-5p as a microRNA (miRNA) that targeted CACNA1A IRES and preferentially inhibited the CACNA1A IRES-driven translation of α1ACT in an Argonaute 4 (Ago4)-dependent manner. We found that eukaryotic initiation factors (eIFs), eIF4AII and eIF4GII, interacted with the CACNA1A IRES to enhance α1ACT translation. Ago4-bound miR-3191-5p blocked the interaction of eIF4AII and eIF4GII with the CACNA1A IRES, attenuating IRES-driven α1ACT translation. Furthermore, AAV9-mediated delivery of miR-3191-5p protected mice from the ataxia, motor deficits, and Purkinje cell degeneration caused by CACNA1A IRES-driven α1ACTSCA6 We have established proof of principle that viral delivery of an miRNA can rescue a disease phenotype through modulation of cellular IRES activity in a mouse model. Copyright © 2016, American Association for the Advancement of Science.

An miRNA-mediated therapy for SCA6 blocks IRES-driven translation of the CACNA1A second cistron

PubMed Central

Miyazaki, Yu; Du, Xiaofei; Muramatsu, Shin-ichi; Gomez, Christopher M.

2017-01-01

Spinocerebellar ataxia type 6 (SCA6) is a dominantly inherited neurodegenerative disease characterized by slowly progressive ataxia and Purkinje cell degeneration. SCA6 is caused by a polyglutamine repeat expansion within a second CACNA1A gene product, α1ACT. α1ACT expression is under the control of an internal ribosomal entry site (IRES) present within the CACNA1A coding region. Whereas SCA6 allele knock-in mice show indistinguishable phenotypes from wild-type littermates, expression of SCA6-associated α1ACT (α1ACTSCA6) driven by a Purkinje cell–specific promoter in mice produces slowly progressive ataxia and cerebellar atrophy. We developed an early-onset SCA6 mouse model using an adeno-associated virus (AAV)–based gene delivery system to ectopically express CACNA1A IRES–driven α1ACTSCA6 to test the potential of CACNA1A IRES–targeting therapies. Mice expressing AAV9-mediated CACNA1A IRES–driven α1ACTSCA6 exhibited early-onset ataxia, motor deficits, and Purkinje cell degeneration. We identified miR-3191-5p as a microRNA (miRNA) that targeted CACNA1A IRES and preferentially inhibited the CACNA1A IRES–driven translation of α1ACT in an Argonaute 4 (Ago4)–dependent manner. We found that eukaryotic initiation factors (eIFs), eIF4AII and eIF4GII, interacted with the CACNA1A IRES to enhance α1ACT translation. Ago4-bound miR-3191-5p blocked the interaction of eIF4AII and eIF4GII with the CACNA1A IRES, attenuating IRES-driven α1ACT translation. Furthermore, AAV9-mediated delivery of miR-3191-5p protected mice from the ataxia, motor deficits, and Purkinje cell degeneration caused by CACNA1A IRES–driven α1ACTSCA6. We have established proof of principle that viral delivery of an miRNA can rescue a disease phenotype through modulation of cellular IRES activity in a mouse model. PMID:27412786

Development Status of Ion Source at J-PARC Linac Test Stand

NASA Astrophysics Data System (ADS)

Yamazaki, S.; Takagi, A.; Ikegami, K.; Ohkoshi, K.; Ueno, A.; Koizumi, I.; Oguri, H.

The Japan Proton Accelerator Research Complex (J-PARC) linac power upgrade program is now in progress in parallel with user operation. To realize a nominal performance of 1 MW at 3 GeV Rapid Cycling Synchrotron and 0.75 MW at the Main Ring synchrotron, we need to upgrade the peak beam current (50 mA) of the linac. For the upgrade program, we are testing a new front-end system, which comprises a cesiated RF-driven H- ion source and a new radio -frequency quadrupole linac (RFQ). The H- ion source was developed to satisfy the J-PARC upgrade requirements of an H- ion-beam current of 60 mA and a lifetime of more than 50 days. On February 6, 2014, the first 50 mA H- beams were accelerated by the RFQ during a beam test. To demonstrate the performance of the ion source before its installation in the summer of 2014, we tested the long-term stability through continuous beam operation, which included estimating the lifetime of the RF antenna and evaluating the cesium consumption.

Late Glacial-Holocene record of benthic foraminiferal morphogroups from the eastern Arabian Sea OMZ: Paleoenvironmental implications

NASA Astrophysics Data System (ADS)

Verma, K.; Bharti, S. K.; Singh, A. D.

2018-03-01

The Arabian Sea is characterized today by a well-developed and perennial oxygen minimum zone (OMZ) at mid-water depths. The Indian margin where the OMZ impinges provides sediment records ideal to study past changes in the OMZ intensity and its vertical extent in response to the changes of monsoon-driven primary productivity and intermediate water ventilation. Benthic foraminifera, depending upon their adaptation capabilities to variation in sea floor environment and microhabitat preferences, develop various functional morphologies that can be potentially used in paleoenvironmental reconstruction. In this study, we analysed benthic foraminiferal morphogroups in assemblage records of the last 30 ka in a sediment core collected from the lower OMZ of the Indian margin (off Goa). In total, nine morphogroups within two broadly classified epifaunal and infaunal microhabitat categories are identified. The abundance of morphogroups varies significantly during the late Glacial, Deglacial and Holocene. It appears that monsoon wind driven organic matter flux, and water column ventilation governing the OMZ intensity and sea-bottom oxygen condition, have profound influence on structuring the benthic foraminiferal morphogroups. We found a few morphogroups showing major changes in their abundances during the periods corresponding to the northern hemisphere climatic events. Benthic foraminifera with planoconvex tests are abundant during the cold Heinrich events, when the sea bottom was oxygenated due to a better ventilated, weak OMZ; whereas, those having tapered/cylindrical tests dominate during the last glacial maximum and the Holocene between 5 and 8 ka BP, when the OMZ was intensified and poorly ventilated, leading to oxygen-depleted benthic environment. Characteristically, increased abundance of taxa with milioline tests during the Heinrich 1 further suggests enhanced ventilation attributed probably to the influence of oxygen-rich Antarctic Intermediate Water (AAIW).

Value-of-information analysis within a stakeholder-driven research prioritization process in a US setting: an application in cancer genomics.

PubMed

Carlson, Josh J; Thariani, Rahber; Roth, Josh; Gralow, Julie; Henry, N Lynn; Esmail, Laura; Deverka, Pat; Ramsey, Scott D; Baker, Laurence; Veenstra, David L

2013-05-01

The objective of this study was to evaluate the feasibility and outcomes of incorporating value-of-information (VOI) analysis into a stakeholder-driven research prioritization process in a US-based setting. . Within a program to prioritize comparative effectiveness research areas in cancer genomics, over a period of 7 months, we developed decision-analytic models and calculated upper-bound VOI estimates for 3 previously selected genomic tests. Thirteen stakeholders representing patient advocates, payers, test developers, regulators, policy makers, and community-based oncologists ranked the tests before and after receiving VOI results. The stakeholders were surveyed about the usefulness and impact of the VOI findings. The estimated upper-bound VOI ranged from $33 million to $2.8 billion for the 3 research areas. Seven stakeholders indicated the results modified their rankings, 9 stated VOI data were useful, and all indicated they would support its use in future prioritization processes. Some stakeholders indicated expected value of sampled information might be the preferred choice when evaluating specific Limitations. Our study was limited by the size and the potential for selection bias in the composition of the external stakeholder group, lack of a randomized design to assess effect of VOI data on rankings, and the use of expected value of perfect information v. expected value of sample information methods. Value of information analyses may have a meaningful role in research topic prioritization for comparative effectiveness research in the United States, particularly when large differences in VOI across topic areas are identified. Additional research is needed to facilitate the use of more complex value of information analyses in this setting.

Development of a Scale to Measure Learners' Perceived Preferences and Benefits of Data-Driven Learning

ERIC Educational Resources Information Center

Mizumoto, Atsushi; Chujo, Kiyomi; Yokota, Kenji

2016-01-01

In spite of researchers' and practitioners' increasing attention to data-driven learning (DDL) and increasing numbers of DDL studies, a multi-item scale to measure learners' attitude toward DDL has not been developed thus far. In the present study, we developed and validated a psychometric scale to measure learners' perceived preferences and…

Research on the Mode of Technology Innovation Alliance of the New Material Industry in Hunan Province

NASA Astrophysics Data System (ADS)

Wang, Fan

2018-03-01

One of the main directions of technology development in the 21st century is the development and application of new materials, and the key to the development of the new material industry lies in the industrial technology innovation. The gross scale of the new material industry in Hunan Province ranks the first array in China. Based on the present situation of Hunan’s new material industry, three modes of technology innovation alliance are put forward in this paper, namely the government-driven mode, the research-driven and the market-oriented mode. The government-driven mode is applicable to the major technology innovation fields with uncertain market prospect, high risk of innovation and government’s direct or indirect intervention;the research-driven mode is applicable to the key technology innovation fields with a high technology content; and the market-oriented mode is applicable to the general innovation fields in which enterprises have demands for technology innovation but such innovation must be achieved via cooperative research and development.

Data-driven Modelling for decision making under uncertainty

NASA Astrophysics Data System (ADS)

Angria S, Layla; Dwi Sari, Yunita; Zarlis, Muhammad; Tulus

2018-01-01

The rise of the issues with the uncertainty of decision making has become a very warm conversation in operation research. Many models have been presented, one of which is with data-driven modelling (DDM). The purpose of this paper is to extract and recognize patterns in data, and find the best model in decision-making problem under uncertainty by using data-driven modeling approach with linear programming, linear and nonlinear differential equation, bayesian approach. Model criteria tested to determine the smallest error, and it will be the best model that can be used.

A capillary-driven micromixer: idea and fabrication

NASA Astrophysics Data System (ADS)

Lee, Chun-Te; Lee, Chun-Che

2012-10-01

Microfluidic systems have been drawing attention upon the various branches of engineering science and the allied areas within biology and biomedicine. In this paper, a fabrication of a capillary-driven micromixer using photoresist JSR and glasses is proposed. We design three types of planar capillary-driven micormixers with different sizes of baffles in the channel. Flow tests have shown that the micromixer with a baffle gap of 100 μm and space of 100 μm reaches a best mixing performance of 93% in gray-level image analysis.

Anaemia management protocols in the care of haemodialysis patients: examining patient outcomes.

PubMed

Saunders, Sushila; MacLeod, Martha L P; Salyers, Vince; MacMillan, Peter D; Ogborn, Malcolm R

2013-08-01

To determine whether the use of a nurse-driven protocol in the haemodialysis setting is as safe and effective as traditional physician-driven approaches to anaemia management. The role of haemodialysis nurses in renal anaemia management has evolved through the implementation of nurse-driven protocols, addressing the trend of exceeding haemoglobin targets and rising costs of erythropoietin-stimulating agents. Retrospective, non-equivalent case control group design. The sample was from three haemodialysis units in a control group (n = 64) and three haemodialysis units in a protocol group (n = 43). The protocol group used a nurse-driven renal anaemia management protocol, while the control group used a traditional physician-driven approach to renal anaemia management. All retrospective data were obtained from a provincial renal database. Data were analysed using chi-square tests and t-tests. Patient outcomes examined were haemoglobin levels, transferrin saturation levels, erythropoietin-stimulating agents use and intravenous iron use. Cost comparisons were determined using average use of erythropoietin-stimulating agents and intravenous iron. Control and protocol groups reached haemoglobin target levels. In the protocol group, 75% reached transferrin saturation target levels in comparison with 25% of the control group. Use and costs for iron was higher in the control group, while use and costs for erythropoietin was higher in the protocol group. The higher usage of erythropoietin-stimulating agents was potentially related to comorbid conditions amongst the protocol group. A nurse-driven protocol approach to renal anaemia management was as effective as the physician-driven approach in reaching haemoglobin and transferrin saturation levels. Further examination of the use and dosing of erythropoietin-stimulating agents and intravenous iron, their impact on haemoglobin levels related to patient comorbidities and subsequent cost effectiveness of protocols is required. Using a nurse-driven protocol in practice supports the independent nursing role while contributing to safe patient outcomes. © 2013 Blackwell Publishing Ltd.

Pneumatic pressure wave generator provides economical, simple testing of pressure transducers

NASA Technical Reports Server (NTRS)

Gaal, A. E.; Weldon, T. P.

1967-01-01

Testing device utilizes the change in pressure about a bias or reference pressure level produced by displacement of a center-driven piston in a closed cylinder. Closely controlled pneumatic pressure waves allow testing under dynamic conditions.

Search Pathways: Modeling GeoData Search Behavior to Support Usable Application Development

NASA Astrophysics Data System (ADS)

Yarmey, L.; Rosati, A.; Tressel, S.

2014-12-01

Recent technical advances have enabled development of new scientific data discovery systems. Metadata brokering, linked data, and other mechanisms allow users to discover scientific data of interes across growing volumes of heterogeneous content. Matching this complex content with existing discovery technologies, people looking for scientific data are presented with an ever-growing array of features to sort, filter, subset, and scan through search returns to help them find what they are looking for. This paper examines the applicability of available technologies in connecting searchers with the data of interest. What metrics can be used to track success given shifting baselines of content and technology? How well do existing technologies map to steps in user search patterns? Taking a user-driven development approach, the team behind the Arctic Data Explorer interdisciplinary data discovery application invested heavily in usability testing and user search behavior analysis. Building on earlier library community search behavior work, models were developed to better define the diverse set of thought processes and steps users took to find data of interest, here called 'search pathways'. This research builds a deeper understanding of the user community that seeks to reuse scientific data. This approach ensures that development decisions are driven by clearly articulated user needs instead of ad hoc technology trends. Initial results from this research will be presented along with lessons learned for other discovery platform development and future directions for informatics research into search pathways.

Development of a Ground Test and Analysis Protocol to Support NASA's NextSTEP Phase 2 Habitation Concepts

NASA Technical Reports Server (NTRS)

Beaton, Kara H.; Chappell, Steven P.; Bekdash, Omar S.; Gernhardt, Michael L.

2018-01-01

The NASA Next Space Technologies for Exploration Partnerships (NextSTEP) program is a public-private partnership model that seeks commercial development of deep space exploration capabilities to support extensive human spaceflight missions around and beyond cislunar space. NASA first issued the Phase 1 NextSTEP Broad Agency Announcement to U.S. industries in 2014, which called for innovative cislunar habitation concepts that leveraged commercialization plans for low Earth orbit. These habitats will be part of the Deep Space Gateway (DSG), the cislunar space station planned by NASA for construction in the 2020s. In 2016, Phase 2 of the NextSTEP program selected five commercial partners to develop ground prototypes. A team of NASA research engineers and subject matter experts have been tasked with developing the ground test protocol that will serve as the primary means by which these Phase 2 prototype habitats will be evaluated. Since 2008, this core test team has successfully conducted multiple spaceflight analog mission evaluations utilizing a consistent set of operational products, tools, methods, and metrics to enable the iterative development, testing, analysis, and validation of evolving exploration architectures, operations concepts, and vehicle designs. The purpose of implementing a similar evaluation process for the NextSTEP Phase 2 Habitation Concepts is to consistently evaluate the different commercial partner ground prototypes to provide data-driven, actionable recommendations for Phase 3.

Quantitative Accelerated Life Testing of MEMS Accelerometers.

PubMed

Bâzu, Marius; Gălăţeanu, Lucian; Ilian, Virgil Emil; Loicq, Jerome; Habraken, Serge; Collette, Jean-Paul

2007-11-20

Quantitative Accelerated Life Testing (QALT) is a solution for assessing thereliability of Micro Electro Mechanical Systems (MEMS). A procedure for QALT is shownin this paper and an attempt to assess the reliability level for a batch of MEMSaccelerometers is reported. The testing plan is application-driven and contains combinedtests: thermal (high temperature) and mechanical stress. Two variants of mechanical stressare used: vibration (at a fixed frequency) and tilting. Original equipment for testing at tiltingand high temperature is used. Tilting is appropriate as application-driven stress, because thetilt movement is a natural environment for devices used for automotive and aerospaceapplications. Also, tilting is used by MEMS accelerometers for anti-theft systems. The testresults demonstrated the excellent reliability of the studied devices, the failure rate in the"worst case" being smaller than 10 -7 h -1 .

Data-driven non-linear elasticity: constitutive manifold construction and problem discretization

NASA Astrophysics Data System (ADS)

Ibañez, Ruben; Borzacchiello, Domenico; Aguado, Jose Vicente; Abisset-Chavanne, Emmanuelle; Cueto, Elias; Ladeveze, Pierre; Chinesta, Francisco

2017-11-01

The use of constitutive equations calibrated from data has been implemented into standard numerical solvers for successfully addressing a variety problems encountered in simulation-based engineering sciences (SBES). However, the complexity remains constantly increasing due to the need of increasingly detailed models as well as the use of engineered materials. Data-Driven simulation constitutes a potential change of paradigm in SBES. Standard simulation in computational mechanics is based on the use of two very different types of equations. The first one, of axiomatic character, is related to balance laws (momentum, mass, energy,\\ldots ), whereas the second one consists of models that scientists have extracted from collected, either natural or synthetic, data. Data-driven (or data-intensive) simulation consists of directly linking experimental data to computers in order to perform numerical simulations. These simulations will employ laws, universally recognized as epistemic, while minimizing the need of explicit, often phenomenological, models. The main drawback of such an approach is the large amount of required data, some of them inaccessible from the nowadays testing facilities. Such difficulty can be circumvented in many cases, and in any case alleviated, by considering complex tests, collecting as many data as possible and then using a data-driven inverse approach in order to generate the whole constitutive manifold from few complex experimental tests, as discussed in the present work.

Open Architecture Data System for NASA Langley Combined Loads Test System

NASA Technical Reports Server (NTRS)

Lightfoot, Michael C.; Ambur, Damodar R.

1998-01-01

The Combined Loads Test System (COLTS) is a new structures test complex that is being developed at NASA Langley Research Center (LaRC) to test large curved panels and cylindrical shell structures. These structural components are representative of aircraft fuselage sections of subsonic and supersonic transport aircraft and cryogenic tank structures of reusable launch vehicles. Test structures are subjected to combined loading conditions that simulate realistic flight load conditions. The facility consists of two pressure-box test machines and one combined loads test machine. Each test machine possesses a unique set of requirements or research data acquisition and real-time data display. Given the complex nature of the mechanical and thermal loads to be applied to the various research test articles, each data system has been designed with connectivity attributes that support both data acquisition and data management functions. This paper addresses the research driven data acquisition requirements for each test machine and demonstrates how an open architecture data system design not only meets those needs but provides robust data sharing between data systems including the various control systems which apply spectra of mechanical and thermal loading profiles.

Database-driven web interface automating gyrokinetic simulations for validation

NASA Astrophysics Data System (ADS)

Ernst, D. R.

2010-11-01

We are developing a web interface to connect plasma microturbulence simulation codes with experimental data. The website automates the preparation of gyrokinetic simulations utilizing plasma profile and magnetic equilibrium data from TRANSP analysis of experiments, read from MDSPLUS over the internet. This database-driven tool saves user sessions, allowing searches of previous simulations, which can be restored to repeat the same analysis for a new discharge. The website includes a multi-tab, multi-frame, publication quality java plotter Webgraph, developed as part of this project. Input files can be uploaded as templates and edited with context-sensitive help. The website creates inputs for GS2 and GYRO using a well-tested and verified back-end, in use for several years for the GS2 code [D. R. Ernst et al., Phys. Plasmas 11(5) 2637 (2004)]. A centralized web site has the advantage that users receive bug fixes instantaneously, while avoiding the duplicated effort of local compilations. Possible extensions to the database to manage run outputs, toward prototyping for the Fusion Simulation Project, are envisioned. Much of the web development utilized support from the DoE National Undergraduate Fellowship program [e.g., A. Suarez and D. R. Ernst, http://meetings.aps.org/link/BAPS.2005.DPP.GP1.57.

DEVELOPING THE TRANSDISCIPLINARY AGING RESEARCH AGENDA: NEW DEVELOPMENTS IN BIG DATA.

PubMed

Callaghan, Christian William

2017-07-19

In light of dramatic advances in big data analytics and the application of these advances in certain scientific fields, new potentialities exist for breakthroughs in aging research. Translating these new potentialities to research outcomes for aging populations, however, remains a challenge, as underlying technologies which have enabled exponential increases in 'big data' have not yet enabled a commensurate era of 'big knowledge,' or similarly exponential increases in biomedical breakthroughs. Debates also reveal differences in the literature, with some arguing big data analytics heralds a new era associated with the 'end of theory' or which makes the scientific method obsolete, where correlation supercedes causation, whereby science can advance without theory and hypotheses testing. On the other hand, others argue theory cannot be subordinate to data, no matter how comprehensive data coverage can ultimately become. Given these two tensions, namely between exponential increases in data absent exponential increases in biomedical research outputs, and between the promise of comprehensive data coverage and data-driven inductive versus theory-driven deductive modes of enquiry, this paper seeks to provide a critical review of certain theory and literature that offers useful perspectives of certain developments in big data analytics and their theoretical implications for aging research. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Model driven development of clinical information sytems using openEHR.

PubMed

Atalag, Koray; Yang, Hong Yul; Tempero, Ewan; Warren, Jim

2011-01-01

openEHR and the recent international standard (ISO 13606) defined a model driven software development methodology for health information systems. However there is little evidence in the literature describing implementation; especially for desktop clinical applications. This paper presents an implementation pathway using .Net/C# technology for Microsoft Windows desktop platforms. An endoscopy reporting application driven by openEHR Archetypes and Templates has been developed. A set of novel GUI directives has been defined and presented which guides the automatic graphical user interface generator to render widgets properly. We also reveal the development steps and important design decisions; from modelling to the final software product. This might provide guidance for other developers and form evidence required for the adoption of these standards for vendors and national programs alike.

Saturn Apollo Program

NASA Image and Video Library

1963-05-10

The Marshall Space Flight Center (MSFC) played a crucial role in the development of the huge Saturn rockets that delivered humans to the moon in the 1960s. Many unique facilities existed at MSFC for the development and testing of the Saturn rockets. Affectionately nicknamed “The Arm Farm”, the Random Motion/ Lift-Off Simulator was one of those unique facilities. This facility was developed to test the swingarm mechanisms that were used to hold the rocket in position until lift-off. The Arm Farm provided the capability of testing the detachment and reconnection of various arms under brutally realistic conditions. The 18-acre facility consisted of more than a half dozen arm test positions and one position for testing access arms used by the Apollo astronauts. Each test position had two elements: a vehicle simulator for duplicating motions during countdown and launch; and a section duplicating the launch tower. The vehicle simulator duplicated the portion of the vehicle skin that contained the umbilical connections and personnel access hatches. Driven by a hydraulic servo system, the vehicle simulator produced relative motion between the vehicle and tower. On the Arm Farm, extreme environmental conditions (such as a launch scrub during an approaching Florida thunderstorm) could be simulated. The dramatic scenes that the Marshall engineers and technicians created at the Arm Farm permitted the gathering of crucial technical and engineering data to ensure a successful real time launch from the Kennedy Space Center.

Saturn Apollo Program

NASA Image and Video Library

1967-07-28

The Marshall Space Flight Center (MSFC) played a crucial role in the development of the huge Saturn rockets that delivered humans to the moon in the 1960s. Many unique facilities existed at MSFC for the development and testing of the Saturn rockets. Affectionately nicknamed “The Arm Farm”, the Random Motion/ Lift-Off Simulator was one of those unique facilities. This facility was developed to test the swingarm mechanisms that were used to hold the rocket in position until lift-off. The Arm Farm provided the capability of testing the detachment and reconnection of various arms under brutally realistic conditions. The 18-acre facility consisted of more than a half dozen arm test positions and one position for testing access arms used by the Apollo astronauts. Each test position had two elements: a vehicle simulator for duplicating motions during countdown and launch; and a section duplicating the launch tower. The vehicle simulator duplicated the portion of the vehicle skin that contained the umbilical connections and personnel access hatches. Driven by a hydraulic servo system, the vehicle simulator produced relative motion between the vehicle and tower. On the Arm Farm, extreme environmental conditions (such as a launch scrub during an approaching Florida thunderstorm) could be simulated. The dramatic scenes that the Marshall engineers and technicians created at the Arm Farm permitted the gathering of crucial technical and engineering data to ensure a successful real time launch from the Kennedy Space Center.

A Psychometric Approach to Theory-Based Behavior Change Intervention Development: Example From the Colorado Meaning-Activity Project.

PubMed

Masters, Kevin S; Ross, Kaile M; Hooker, Stephanie A; Wooldridge, Jennalee L

2018-05-18

There has been a notable disconnect between theories of behavior change and behavior change interventions. Because few interventions are both explicitly and adequately theory-based, investigators cannot assess the impact of theory on intervention effectiveness. Theory-based interventions, designed to deliberately engage the theory's proposed mechanisms of change, are needed to adequately test theories. Thus, systematic approaches to theory-based intervention development are needed. This article will introduce and discuss the psychometric method of developing theory-based interventions. The psychometric approach to intervention development utilizes basic psychometric principles at each step of the intervention development process in order to build a theoretically driven intervention to, subsequently, be tested in process (mechanism) and outcome studies. Five stages of intervention development are presented as follows: (i) Choice of theory; (ii) Identification and characterization of key concepts and expected relations; (iii) Intervention construction; (iv) Initial testing and revision; and (v) Empirical testing of the intervention. Examples of this approach from the Colorado Meaning-Activity Project (COMAP) are presented. Based on self-determination theory integrated with meaning or purpose, and utilizing a motivational interviewing approach, the COMAP intervention is individually based with an initial interview followed by smart phone-delivered interventions for increasing daily activity. The psychometric approach to intervention development is one method to ensure careful consideration of theory in all steps of intervention development. This structured approach supports developing a research culture that endorses deliberate and systematic operationalization of theory into behavior change intervention from the outset of intervention development.

The terminator "toy" chemistry test: A simple tool to assess errors in transport schemes

DOE PAGES

Lauritzen, P. H.; Conley, A. J.; Lamarque, J. -F.; ...

2015-05-04

This test extends the evaluation of transport schemes from prescribed advection of inert scalars to reactive species. The test consists of transporting two interacting chemical species in the Nair and Lauritzen 2-D idealized flow field. The sources and sinks for these two species are given by a simple, but non-linear, "toy" chemistry that represents combination (X+X → X 2) and dissociation (X 2 → X+X). This chemistry mimics photolysis-driven conditions near the solar terminator, where strong gradients in the spatial distribution of the species develop near its edge. Despite the large spatial variations in each species, the weighted sum Xmore » T = X+2X 2 should always be preserved at spatial scales at which molecular diffusion is excluded. The terminator test demonstrates how well the advection–transport scheme preserves linear correlations. Chemistry–transport (physics–dynamics) coupling can also be studied with this test. Examples of the consequences of this test are shown for illustration.« less

30 CFR 18.67 - Static-pressure tests.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Static-pressure tests. 18.67 Section 18.67 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Inspections and Tests § 18...

Retrieval-Induced Forgetting in Perceptually Driven Memory Tests

ERIC Educational Resources Information Center

Bajo, M. Teresa; Gomez-Ariza, Carlos J.; Fernandez, Angel; Marful, Alejandra

2006-01-01

Recent data (T. J. Perfect, C. J. A. Moulin, M. A. Conway, & E. Perry, 2002) have suggested that retrieval-induced forgetting (RIF) depends on conceptual memory because the effect is not found in perceptually driven tasks. In 3 experiments, the authors aimed to show that the presence of RIF depends on whether the procedure induces appropriate…

The Use of Mixed Methods in Randomized Control Trials

ERIC Educational Resources Information Center

White, Howard

2013-01-01

Evaluations should be issues driven, not methods driven. The starting point should be priority programs to be evaluated or policies to be tested. From this starting point, a list of evaluation questions is identified. For each evaluation question, the task is to identify the best available method for answering that question. Hence it is likely…

International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes.

PubMed

Bal-Price, Anna; Crofton, Kevin M; Leist, Marcel; Allen, Sandra; Arand, Michael; Buetler, Timo; Delrue, Nathalie; FitzGerald, Rex E; Hartung, Thomas; Heinonen, Tuula; Hogberg, Helena; Bennekou, Susanne Hougaard; Lichtensteiger, Walter; Oggier, Daniela; Paparella, Martin; Axelstad, Marta; Piersma, Aldert; Rached, Eva; Schilter, Benoît; Schmuck, Gabriele; Stoppini, Luc; Tongiorgi, Enrico; Tiramani, Manuela; Monnet-Tschudi, Florianne; Wilks, Martin F; Ylikomi, Timo; Fritsche, Ellen

2015-02-01

A major problem in developmental neurotoxicity (DNT) risk assessment is the lack of toxicological hazard information for most compounds. Therefore, new approaches are being considered to provide adequate experimental data that allow regulatory decisions. This process requires a matching of regulatory needs on the one hand and the opportunities provided by new test systems and methods on the other hand. Alignment of academically and industrially driven assay development with regulatory needs in the field of DNT is a core mission of the International STakeholder NETwork (ISTNET) in DNT testing. The first meeting of ISTNET was held in Zurich on 23-24 January 2014 in order to explore the concept of adverse outcome pathway (AOP) to practical DNT testing. AOPs were considered promising tools to promote test systems development according to regulatory needs. Moreover, the AOP concept was identified as an important guiding principle to assemble predictive integrated testing strategies (ITSs) for DNT. The recommendations on a road map towards AOP-based DNT testing is considered a stepwise approach, operating initially with incomplete AOPs for compound grouping, and focussing on key events of neurodevelopment. Next steps to be considered in follow-up activities are the use of case studies to further apply the AOP concept in regulatory DNT testing, making use of AOP intersections (common key events) for economic development of screening assays, and addressing the transition from qualitative descriptions to quantitative network modelling.

Rules of thumb to increase the software quality through testing

NASA Astrophysics Data System (ADS)

Buttu, M.; Bartolini, M.; Migoni, C.; Orlati, A.; Poppi, S.; Righini, S.

2016-07-01

The software maintenance typically requires 40-80% of the overall project costs, and this considerable variability mostly depends on the software internal quality: the more the software is designed and implemented to constantly welcome new changes, the lower will be the maintenance costs. The internal quality is typically enforced through testing, which in turn also affects the development and maintenance costs. This is the reason why testing methodologies have become a major concern for any company that builds - or is involved in building - software. Although there is no testing approach that suits all contexts, we infer some general guidelines learned during the Development of the Italian Single-dish COntrol System (DISCOS), which is a project aimed at producing the control software for the three INAF radio telescopes (the Medicina and Noto dishes, and the newly-built SRT). These guidelines concern both the development and the maintenance phases, and their ultimate goal is to maximize the DISCOS software quality through a Behavior-Driven Development (BDD) workflow beside a continuous delivery pipeline. We consider different topics and patterns; they involve the proper apportion of the tests (from end-to-end to low-level tests), the choice between hardware simulators and mockers, why and how to apply TDD and the dependency injection to increase the test coverage, the emerging technologies available for test isolation, bug fixing, how to protect the system from the external resources changes (firmware updating, hardware substitution, etc.) and, eventually, how to accomplish BDD starting from functional tests and going through integration and unit tests. We discuss pros and cons of each solution and point out the motivations of our choices either as a general rule or narrowed in the context of the DISCOS project.

Personally Driven Professional Development: Reflective Self-Study as a Way for Teachers to Take Control of Their Own Professional Development

ERIC Educational Resources Information Center

Attard, Karl

2017-01-01

This article is about personally driven professional development through the use of reflective self-study. The argument that teachers need to take responsibility for their own learning while also taking decisions on how and in what areas to develop is strongly made throughout the article. Data for this article were gathered over a 10-year period…

The Role of Emotion-Driven Impulse Control Difficulties in the Relation Between Social Anxiety and Aggression.

PubMed

Dixon, Laura J; Tull, Matthew T; Lee, Aaron A; Kimbrel, Nathan A; Gratz, Kim L

2017-06-01

To enhance our understanding of the factors that may account for increased aggression in socially anxious individuals, this study examined associations among emotion-driven impulse control difficulties, social anxiety, and dimensions of aggression (i.e., hostility, anger, physical aggression, verbal aggression). Individuals (N = 107; 73.8% male; M age = 40.8 years) receiving residential substance abuse treatment participated in this cross-sectional study. Social anxiety symptoms were significantly positively correlated with emotion-driven impulse control difficulties, anger, and hostility, but not verbal or physical aggression. Separate models for each aggression facet were examined to test the direct and indirect paths. Bootstrapped mediation analyses indicated a significant indirect path from social anxiety symptoms to each facet of aggression through emotion-driven impulse control difficulties (ps < .05). Results highlight the potential utility of targeting emotion-driven impulse control difficulties to decrease aggression among socially anxious individuals. © 2016 Wiley Periodicals, Inc.

U.S. hydropower resource assessment for Idaho

DOE Office of Scientific and Technical Information (OSTI.GOV)

Conner, A.M.; Francfort, J.E.

1998-08-01

The US Department of Energy is developing an estimate of the undeveloped hydropower potential in the US. The Hydropower Evaluation Software (HES) is a computer model that was developed by the Idaho National Engineering and Environmental Laboratory for this purpose. HES measures the undeveloped hydropower resources available in the US, using uniform criteria for measurement. The software was developed and tested using hydropower information and data provided by the Southwestern Power Administration. It is a menu-driven program that allows the personal computer user to assign environmental attributes to potential hydropower sites, calculate development suitability factors for each site based onmore » the environmental attributes present, and generate reports based on these suitability factors. This report describes the resource assessment results for the State of Idaho.« less

Radio frequency multicusp ion source development (invited)

NASA Astrophysics Data System (ADS)

Leung, K. N.

1996-03-01

The radio-frequency (rf) driven multicusp source was originally developed for use in the Superconducting Super Collider injector. It has been demonstrated that the source can meet the H- beam current and emittance requirements for this application. By employing a porcelain-coated antenna, a clean plasma discharge with very long-life operation can be achieved. Today, the rf source is used to generate both positive and negative hydrogen ion beams and has been tested in various particle accelerator laboratories throughout the world. Applications of this ion source have been extended to other fields such as ion beam lithography, oil-well logging, ion implantation, accelerator mass spectrometry and medical therapy machines. This paper summarizes the latest rf ion source technology and development at the Lawrence Berkeley National Laboratory.

Development of Quasi-3DOF upper limb rehabilitation system using ER brake: PLEMO-P1

NASA Astrophysics Data System (ADS)

Kikuchi, T.; Fukushima, K.; Furusho, J.; Ozawa, T.

2009-02-01

In recent years, many researchers have studied the potential of using robotics technology to assist and quantify the motor functions for neuron-rehabilitation. Some kinds of haptic devices have been developed and evaluated its efficiency with clinical tests, for example, upper limb training for patients with spasticity after stroke. However, almost all the devices are active-type (motor-driven) haptic devices and they basically require high-cost safety system compared to passive-type (brake-based) devices. In this study, we developed a new practical haptic device 'PLEMO-P1'; this system adopted ER brakes as its force generators. In this paper, the mechanism of PLEMO-P1 and its software for a reaching rehabilitation are described.

Testing the efficiency of rover science protocols for robotic sample selection: A GeoHeuristic Operational Strategies Test

NASA Astrophysics Data System (ADS)

Yingst, R. A.; Bartley, J. K.; Chidsey, T. C.; Cohen, B. A.; Gilleaudeau, G. J.; Hynek, B. M.; Kah, L. C.; Minitti, M. E.; Williams, R. M. E.; Black, S.; Gemperline, J.; Schaufler, R.; Thomas, R. J.

2018-05-01

The GHOST field tests are designed to isolate and test science-driven rover operations protocols, to determine best practices. During a recent field test at a potential Mars 2020 landing site analog, we tested two Mars Science Laboratory data-acquisition and decision-making methods to assess resulting science return and sample quality: a linear method, where sites of interest are studied in the order encountered, and a "walkabout-first" method, where sites of interest are examined remotely before down-selecting to a subset of sites that are interrogated with more resource-intensive instruments. The walkabout method cost less time and fewer resources, while increasing confidence in interpretations. Contextual data critical to evaluating site geology was acquired earlier than for the linear method, and given a higher priority, which resulted in development of more mature hypotheses earlier in the analysis process. Combined, this saved time and energy in the collection of data with more limited spatial coverage. Based on these results, we suggest that the walkabout method be used where doing so would provide early context and time for the science team to develop hypotheses-critical tests; and that in gathering context, coverage may be more important than higher resolution.

Agile data management for curation of genomes to watershed datasets

NASA Astrophysics Data System (ADS)

Varadharajan, C.; Agarwal, D.; Faybishenko, B.; Versteeg, R.

2015-12-01

A software platform is being developed for data management and assimilation [DMA] as part of the U.S. Department of Energy's Genomes to Watershed Sustainable Systems Science Focus Area 2.0. The DMA components and capabilities are driven by the project science priorities and the development is based on agile development techniques. The goal of the DMA software platform is to enable users to integrate and synthesize diverse and disparate field, laboratory, and simulation datasets, including geological, geochemical, geophysical, microbiological, hydrological, and meteorological data across a range of spatial and temporal scales. The DMA objectives are (a) developing an integrated interface to the datasets, (b) storing field monitoring data, laboratory analytical results of water and sediments samples collected into a database, (c) providing automated QA/QC analysis of data and (d) working with data providers to modify high-priority field and laboratory data collection and reporting procedures as needed. The first three objectives are driven by user needs, while the last objective is driven by data management needs. The project needs and priorities are reassessed regularly with the users. After each user session we identify development priorities to match the identified user priorities. For instance, data QA/QC and collection activities have focused on the data and products needed for on-going scientific analyses (e.g. water level and geochemistry). We have also developed, tested and released a broker and portal that integrates diverse datasets from two different databases used for curation of project data. The development of the user interface was based on a user-centered design process involving several user interviews and constant interaction with data providers. The initial version focuses on the most requested feature - i.e. finding the data needed for analyses through an intuitive interface. Once the data is found, the user can immediately plot and download data through the portal. The resulting product has an interface that is more intuitive and presents the highest priority datasets that are needed by the users. Our agile approach has enabled us to build a system that is keeping pace with the science needs while utilizing limited resources.

Evolutionary Ensemble for In Silico Prediction of Ames Test Mutagenicity

NASA Astrophysics Data System (ADS)

Chen, Huanhuan; Yao, Xin

Driven by new regulations and animal welfare, the need to develop in silico models has increased recently as alternative approaches to safety assessment of chemicals without animal testing. This paper describes a novel machine learning ensemble approach to building an in silico model for the prediction of the Ames test mutagenicity, one of a battery of the most commonly used experimental in vitro and in vivo genotoxicity tests for safety evaluation of chemicals. Evolutionary random neural ensemble with negative correlation learning (ERNE) [1] was developed based on neural networks and evolutionary algorithms. ERNE combines the method of bootstrap sampling on training data with the method of random subspace feature selection to ensure diversity in creating individuals within an initial ensemble. Furthermore, while evolving individuals within the ensemble, it makes use of the negative correlation learning, enabling individual NNs to be trained as accurate as possible while still manage to maintain them as diverse as possible. Therefore, the resulting individuals in the final ensemble are capable of cooperating collectively to achieve better generalization of prediction. The empirical experiment suggest that ERNE is an effective ensemble approach for predicting the Ames test mutagenicity of chemicals.

¡Cocinar Para Su Salud! Development of a Culturally Based Nutrition Education Curriculum for Hispanic Breast Cancer Survivors Using a Theory-Driven Procedural Model.

PubMed

Aycinena, Ana Corina; Jennings, Kerri-Ann; Gaffney, Ann Ogden; Koch, Pamela A; Contento, Isobel R; Gonzalez, Monica; Guidon, Ela; Karmally, Wahida; Hershman, Dawn; Greenlee, Heather

2017-02-01

We developed a theory-based dietary change curriculum for Hispanic breast cancer survivors with the goal of testing the effects of the intervention on change in dietary intake of fruits/vegetables and fat in a randomized, clinical trial. Social cognitive theory and the transtheoretical model were used as theoretical frameworks to structure curriculum components using the Nutrition Education DESIGN Procedure. Formative assessments were conducted to identify facilitators and barriers common to Hispanic women and test the degree of difficulty and appropriateness of program materials. Focus groups provided valuable insight and informed preimplementation modifications to the dietary program. The result was a systematically planned, evidence-based, culturally tailored dietary intervention for Hispanic breast cancer survivors, ¡Cocinar Para Su Salud! (Cook for Your Health!). The methodology described here may serve as a framework for the development of future dietary interventions among diverse and minority populations. Short- and long-term study results will be reported elsewhere.

Assessing Behavioural Manifestations Prior to Clinical Diagnosis of Huntington Disease: "Anger and Irritability" and "Obsessions and Compulsions"

PubMed Central

Vaccarino, Anthony L; Anonymous; Anderson, Karen E.; Borowsky, Beth; Coccaro, Emil; Craufurd, David; Endicott, Jean; Giuliano, Joseph; Groves, Mark; Guttman, Mark; Ho, Aileen K; Kupchak, Peter; Paulsen, Jane S.; Stanford, Matthew S.; van Kammen, Daniel P; Watson, David; Wu, Kevin D; Evans, Ken

2011-01-01

The Functional Rating Scale Taskforce for pre-Huntington Disease (FuRST-pHD) is a multinational, multidisciplinary initiative with the goal of developing a data-driven, comprehensive, psychometrically sound, rating scale for assessing symptoms and functional ability in prodromal and early Huntington disease (HD) gene expansion carriers. The process involves input from numerous sources to identify relevant symptom domains, including HD individuals, caregivers, and experts from a variety of fields, as well as knowledge gained from the analysis of data from ongoing large-scale studies in HD using existing clinical scales. This is an iterative process in which an ongoing series of field tests in prodromal (prHD) and early HD individuals provides the team with data on which to make decisions regarding which questions should undergo further development or testing and which should be excluded. We report here the development and assessment of the first iteration of interview questions aimed to assess "Anger and Irritability" and "Obsessions and Compulsions" in prHD individuals. PMID:21826116

Testing collapse models by a thermometer

NASA Astrophysics Data System (ADS)

Bahrami, M.

2018-05-01

Collapse models postulate that space is filled with a collapse noise field, inducing quantum Brownian motions, which are dominant during the measurement, thus causing collapse of the wave function. An important manifestation of the collapse noise field, if any, is thermal energy generation, thus disturbing the temperature profile of a system. The experimental investigation of a collapse-driven heating effect has provided, so far, the most promising test of collapse models against standard quantum theory. In this paper, we calculate the collapse-driven heat generation for a three-dimensional multi-atomic Bravais lattice by solving stochastic Heisenberg equations. We perform our calculation for the mass-proportional continuous spontaneous localization collapse model with nonwhite noise. We obtain the temperature distribution of a sphere under stationary-state and insulated surface conditions. However, the exact quantification of the collapse-driven heat-generation effect highly depends on the actual value of cutoff in the collapse noise spectrum.

An earth imaging camera simulation using wide-scale construction of reflectance surfaces

NASA Astrophysics Data System (ADS)

Murthy, Kiran; Chau, Alexandra H.; Amin, Minesh B.; Robinson, M. Dirk

2013-10-01

Developing and testing advanced ground-based image processing systems for earth-observing remote sensing applications presents a unique challenge that requires advanced imagery simulation capabilities. This paper presents an earth-imaging multispectral framing camera simulation system called PayloadSim (PaySim) capable of generating terabytes of photorealistic simulated imagery. PaySim leverages previous work in 3-D scene-based image simulation, adding a novel method for automatically and efficiently constructing 3-D reflectance scenes by draping tiled orthorectified imagery over a geo-registered Digital Elevation Map (DEM). PaySim's modeling chain is presented in detail, with emphasis given to the techniques used to achieve computational efficiency. These techniques as well as cluster deployment of the simulator have enabled tuning and robust testing of image processing algorithms, and production of realistic sample data for customer-driven image product development. Examples of simulated imagery of Skybox's first imaging satellite are shown.

Toward implementation of a national ground water monitoring network

USGS Publications Warehouse

Schreiber, Robert P.; Cunningham, William L.; Copeland, Rick; Frederick, Kevin D.

2008-01-01

The Federal Advisory Committee on Water Information's (ACWI) Subcommittee on Ground Water (SOGW) has been working steadily to develop and encourage implementation of a nationwide, long-term ground-water quantity and quality monitoring framework. Significant progress includes the planned submission this fall of a draft framework document to the full committee. The document will include recommendations for implementation of the network and continued acknowledgment at the federal and state level of ACWI's potential role in national monitoring toward an improved assessment of the nation's water reserves. The SOGW mission includes addressing several issues regarding network design, as well as developing plans for concept testing, evaluation of costs and benefits, and encouraging the movement from pilot-test results to full-scale implementation within a reasonable time period. With the recent attention to water resource sustainability driven by severe droughts, concerns over global warming effects, and persistent water supply problems, the SOGW mission is now even more critical.

Electrostatic Charging of the Pathfinder Rover

NASA Technical Reports Server (NTRS)

Siebert, Mark W.; Kolecki, Joseph C.

1996-01-01

The Mars Pathfinder mission will send a lander and a rover to the martian surface. Because of the extremely dry conditions on Mars, electrostatic charging of the rover is expected to occur as it moves about. Charge accumulation may result in high electrical potentials and discharge through the martian atmosphere. Such discharge could interfere with the operation of electrical elements on the rover. A strategy was sought to mitigate this charge accumulation as a precautionary measure. Ground tests were performed to demonstrate charging in laboratory conditions simulating the surface conditions expected at Mars. Tests showed that a rover wheel, driven at typical rover speeds, will accumulate electrical charge and develop significant electrical potentials (average observed, 110 volts). Measurements were made of wheel electrical potential, and wheel capacitance. From these quantities, the amount of absolute charge was estimated. An engineering solution was developed and recommended to mitigate charge accumulation. That solution has been implemented on the actual rover.

Modelling clinical systemic lupus erythematosus: similarities, differences and success stories

PubMed Central

Celhar, Teja

2017-01-01

Abstract Mouse models of SLE have been indispensable tools to study disease pathogenesis, to identify genetic susceptibility loci and targets for drug development, and for preclinical testing of novel therapeutics. Recent insights into immunological mechanisms of disease progression have boosted a revival in SLE drug development. Despite promising results in mouse studies, many novel drugs have failed to meet clinical end points. This is probably because of the complexity of the disease, which is driven by polygenic predisposition and diverse environmental factors, resulting in a heterogeneous clinical presentation. Each mouse model recapitulates limited aspects of lupus, especially in terms of the mechanism underlying disease progression. The main mouse models have been fairly successful for the evaluation of broad-acting immunosuppressants. However, the advent of targeted therapeutics calls for a selection of the most appropriate model(s) for testing and, ultimately, identification of patients who will be most likely to respond. PMID:28013204

On the value-dependence of value-driven attentional capture.

PubMed

Anderson, Brian A; Halpern, Madeline

2017-05-01

Findings from an increasingly large number of studies have been used to argue that attentional capture can be dependent on the learned value of a stimulus, or value-driven. However, under certain circumstances attention can be biased to select stimuli that previously served as targets, independent of reward history. Value-driven attentional capture, as studied using the training phase-test phase design introduced by Anderson and colleagues, is widely presumed to reflect the combined influence of learned value and selection history. However, the degree to which attentional capture is at all dependent on value learning in this paradigm has recently been questioned. Support for value-dependence can be provided through one of two means: (1) greater attentional capture by prior targets following rewarded training than following unrewarded training, and (2) greater attentional capture by prior targets previously associated with high compared to low value. Using a variant of the original value-driven attentional capture paradigm, Sha and Jiang (Attention, Perception, and Psychophysics, 78, 403-414, 2016) failed to find evidence of either, and raised criticisms regarding the adequacy of evidence provided by prior studies using this particular paradigm. To address this disparity, here we provided a stringent test of the value-dependence hypothesis using the traditional value-driven attentional capture paradigm. With a sufficiently large sample size, value-dependence was observed based on both criteria, with no evidence of attentional capture without rewards during training. Our findings support the validity of the traditional value-driven attentional capture paradigm in measuring what its name purports to measure.

Custom Unit Pump Development for the EVA PLSS

NASA Technical Reports Server (NTRS)

Schuller, Michael; Kurwitz, Cable; Little, Frank; Oinuma, Ryoji; Larsen, Ben; Goldman, Jeff; Reinis, Filip; Trevino, Luis

2010-01-01

This paper describes the effort by the Texas Engineering Experiment Station (TEES) and Honeywell for NASA to design and test a pre-flight prototype pump for use in the Extra-vehicular activity (EVA) portable life support subsystem (PLSS). Major design decisions were driven by the need to reduce the pump s mass, power, and volume compared to the existing PLSS pump. In addition, the pump must accommodate a much wider range of abnormal conditions than the existing pump, including vapor/gas bubbles and increased pressure drop when employed to cool two suits simultaneously. A positive displacement, external gear type pump was selected because it offers the most compact and highest efficiency solution over the required range of flow rates and pressure drops. An additional benefit of selecting a gear pump design is that it is self priming and capable of ingesting non-condensable gas without becoming air locked. The chosen pump design consists of a 28 V DC, brushless, seal-less, permanent magnet motor driven, external gear pump that utilizes a Honeywell development that eliminates the need for magnetic coupling. The pump design was based on existing Honeywell designs, but incorporated features specifically for the PLSS application, including all of the key features of the flight pump. Testing at TEES verified that the pump meets the design requirements for range of flow rates, pressure drop, power consumption, working fluid temperature, operating time, gas ingestion, and restart capability under both ambient and vacuum conditions. The pump operated at 40 to 240 lbm/hr flow rate, 35 to 100 oF pump temperature, and 5 to 10 psid pressure rise. Power consumption of the pump controller at the nominal operating point in both ambient and vacuum conditions was 9.5 W, which was less than the 12 W predicted. Gas ingestion capabilities were tested by injecting 100 cc of air into the fluid line; the pump operated normally throughout this test.

The Development of Teaching and Learning in Bright-Field Microscopy Technique

ERIC Educational Resources Information Center

Iskandar, Yulita Hanum P.; Mahmud, Nurul Ethika; Wahab, Wan Nor Amilah Wan Abdul; Jamil, Noor Izani Noor; Basir, Nurlida

2013-01-01

E-learning should be pedagogically-driven rather than technologically-driven. The objectives of this study are to develop an interactive learning system in bright-field microscopy technique in order to support students' achievement of their intended learning outcomes. An interactive learning system on bright-field microscopy technique was…

Constraint-Driven Software Design: An Escape from the Waterfall Model.

ERIC Educational Resources Information Center

de Hoog, Robert; And Others

1994-01-01

Presents the principles of a development methodology for software design based on a nonlinear, product-driven approach that integrates quality aspects. Two examples are given to show that the flexibility needed for building high quality systems leads to integrated development environments in which methodology, product, and tools are closely…

Primed for Patron-Driven Acquisition: A Look at the Big Picture

ERIC Educational Resources Information Center

Dahl, Candice

2012-01-01

The development of patron-driven acquisition (PDA) as a viable collections practice is encouraging many academic libraries to be proactive about sharing significant collection development responsibilities with their patrons. The adoption of PDA represents a challenge to some long-held understandings about libraries and collections, however, and…

Development of a software tool using deterministic logic for the optimization of cochlear implant processor programming.

PubMed

Govaerts, Paul J; Vaerenberg, Bart; De Ceulaer, Geert; Daemers, Kristin; De Beukelaer, Carina; Schauwers, Karen

2010-08-01

An intelligent agent, Fitting to Outcomes eXpert, was developed to optimize and automate Cochlear implant (CI) programming. The current article describes the rationale, development, and features of this tool. Cochlear implant fitting is a time-consuming procedure to define the value of a subset of the available electric parameters based primarily on behavioral responses. It is comfort-driven with high intraindividual and interindividual variability both with respect to the patient and to the clinician. Its validity in terms of process control can be questioned. Good clinical practice would require an outcome-driven approach. An intelligent agent may help solve the complexity of addressing more electric parameters based on a range of outcome measures. A software application was developed that consists of deterministic rules that analyze the map settings in the processor together with psychoacoustic test results (audiogram, A(section sign)E phoneme discrimination, A(section sign)E loudness scaling, speech audiogram) obtained with that map. The rules were based on the daily clinical practice and the expertise of the CI programmers. The data transfer to and from this agent is either manual or through seamless digital communication with the CI fitting database and the psychoacoustic test suite. It recommends and executes modifications to the map settings to improve the outcome. Fitting to Outcomes eXpert is an operational intelligent agent, the principles of which are described. Its development and modes of operation are outlined, and a case example is given. Fitting to Outcomes eXpert is in use for more than a year now and seems to be capable to improve the measured outcome. It is argued that this novel tool allows a systematic approach focusing on outcome, reducing the fitting time, and improving the quality of fitting. It introduces principles of artificial intelligence in the process of CI fitting.

30 CFR 18.8 - Date for conducting investigation and tests.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES General... determine the order of precedence for investigation and testing. If an electrical machine component or...

User input verification and test driven development in the NJOY21 nuclear data processing code

DOE Office of Scientific and Technical Information (OSTI.GOV)

Trainer, Amelia Jo; Conlin, Jeremy Lloyd; McCartney, Austin Paul

Before physically-meaningful data can be used in nuclear simulation codes, the data must be interpreted and manipulated by a nuclear data processing code so as to extract the relevant quantities (e.g. cross sections and angular distributions). Perhaps the most popular and widely-trusted of these processing codes is NJOY, which has been developed and improved over the course of 10 major releases since its creation at Los Alamos National Laboratory in the mid-1970’s. The current phase of NJOY development is the creation of NJOY21, which will be a vast improvement from its predecessor, NJOY2016. Designed to be fast, intuitive, accessible, andmore » capable of handling both established and modern formats of nuclear data, NJOY21 will address many issues that many NJOY users face, while remaining functional for those who prefer the existing format. Although early in its development, NJOY21 is quickly providing input validation to check user input. By providing rapid and helpful responses to users while writing input files, NJOY21 will prove to be more intuitive and easy to use than any of its predecessors. Furthermore, during its development, NJOY21 is subject to regular testing, such that its test coverage must strictly increase with the addition of any production code. This thorough testing will allow developers and NJOY users to establish confidence in NJOY21 as it gains functionality. This document serves as a discussion regarding the current state input checking and testing practices of NJOY21.« less

Reverse translation of the rodent 5C-CPT reveals that the impaired attention of people with schizophrenia is similar to scopolamine-induced deficits in mice

PubMed Central

Young, J W; Geyer, M A; Rissling, A J; Sharp, R F; Eyler, L T; Asgaard, G L; Light, G A

2013-01-01

Attentional dysfunction in schizophrenia (SZ) is a core deficit that contributes to multiple cognitive deficits and the resulting functional disability. However, developing procognitive therapeutics for neuropsychiatric disorders have been limited by a ‘translational gap'—a lack of cognitive paradigms having cross-species translational validity and relevance. The present study was designed to perform an initial validation of the cross-species homology of the 5-choice Continuous Performance Test (5C-CPT) in healthy nonpsychiatric comparison subjects (NCS), SZ patients and mice under pharmacologic challenge. The 5C-CPT performance in SZ patients (n=20) was compared with age-matched NCS (n=23). The effects of the general muscarinic receptor antagonist scopolamine on mice (n=21) performing the 5C-CPT were also assessed. SZ subjects exhibited significantly impaired attention in the 5C-CPT, driven by reduced target detection over time and nonsignificantly increased impulsive responding. Similarly, scopolamine significantly impaired attention in mice, driven by reduced target detection and nonsignificantly increased impulsive responding. Scopolamine also negatively affected accuracy and speed of responding in mice, although these measures failed to differentiate SZ vs NCS. Thus, mice treated with scopolamine exhibited similar impairments in vigilance as seen in SZ, although the differences between the behavioral profiles warrant further study. The availability of rodent and human versions of this paradigm provides an opportunity to: (1) investigate the neuroanatomic, neurochemical and genomic architecture of abnormalities in attention observed in clinical populations such as SZ; (2) develop and refine animal models of cognitive impairments; and (3) improve cross-species translational testing for the development of treatments for these impairments. PMID:24217494

ObsPy: A Python Toolbox for Seismology

NASA Astrophysics Data System (ADS)

Wassermann, J. M.; Krischer, L.; Megies, T.; Barsch, R.; Beyreuther, M.

2013-12-01

Python combines the power of a full-blown programming language with the flexibility and accessibility of an interactive scripting language. Its extensive standard library and large variety of freely available high quality scientific modules cover most needs in developing scientific processing workflows. ObsPy is a community-driven, open-source project extending Python's capabilities to fit the specific needs that arise when working with seismological data. It a) comes with a continuously growing signal processing toolbox that covers most tasks common in seismological analysis, b) provides read and write support for many common waveform, station and event metadata formats and c) enables access to various data centers, webservices and databases to retrieve waveform data and station/event metadata. In combination with mature and free Python packages like NumPy, SciPy, Matplotlib, IPython, Pandas, lxml, and PyQt, ObsPy makes it possible to develop complete workflows in Python, ranging from reading locally stored data or requesting data from one or more different data centers via signal analysis and data processing to visualization in GUI and web applications, output of modified/derived data and the creation of publication-quality figures. All functionality is extensively documented and the ObsPy Tutorial and Gallery give a good impression of the wide range of possible use cases. ObsPy is tested and running on Linux, OS X and Windows and comes with installation routines for these systems. ObsPy is developed in a test-driven approach and is available under the LGPLv3 open source licence. Users are welcome to request help, report bugs, propose enhancements or contribute code via either the user mailing list or the project page on GitHub.

Space Infrared Telescope Facility (SIRTF) - Operations concept. [decreasing development and operations cost

NASA Technical Reports Server (NTRS)

Miller, Richard B.

1992-01-01

The development and operations costs of the Space IR Telescope Facility (SIRTF) are discussed in the light of minimizing total outlays and optimizing efficiency. The development phase cannot extend into the post-launch segment which is planned to only support system verification and calibration followed by operations with a 70-percent efficiency goal. The importance of reducing the ground-support staff is demonstrated, and the value of the highly sensitive observations to the general astronomical community is described. The Failure Protection Algorithm for the SIRTF is designed for the 5-yr lifetime and the continuous venting of cryogen, and a science driven ground/operations system is described. Attention is given to balancing cost and performance, prototyping during the development phase, incremental development, the utilization of standards, and the integration of ground system/operations with flight system integration and test.

Computational Fluid Dynamics Simulation of Flows in an Oxidation Ditch Driven by a New Surface Aerator

PubMed Central

Huang, Weidong; Li, Kun; Wang, Gan; Wang, Yingzhe

2013-01-01

Abstract In this article, we present a newly designed inverse umbrella surface aerator, and tested its performance in driving flow of an oxidation ditch. Results show that it has a better performance in driving the oxidation ditch than the original one with higher average velocity and more uniform flow field. We also present a computational fluid dynamics model for predicting the flow field in an oxidation ditch driven by a surface aerator. The improved momentum source term approach to simulate the flow field of the oxidation ditch driven by an inverse umbrella surface aerator was developed and validated through experiments. Four kinds of turbulent models were investigated with the approach, including the standard k−ɛ model, RNG k−ɛ model, realizable k−ɛ model, and Reynolds stress model, and the predicted data were compared with those calculated with the multiple rotating reference frame approach (MRF) and sliding mesh approach (SM). Results of the momentum source term approach are in good agreement with the experimental data, and its prediction accuracy is better than MRF, close to SM. It is also found that the momentum source term approach has lower computational expenses, is simpler to preprocess, and is easier to use. PMID:24302850

Mobile Phenotyping System Using an Aeromotively Stabilized Cable-Driven Robot

NASA Astrophysics Data System (ADS)

Newman, M. B.; Zygielbaum, A. I.

2017-12-01

Agricultural researchers are constantly attempting to generate superior agricultural crops. Whether this means creating crops with greater yield, crops that are more resilient to disease, or crops that can tolerate harsh environments with fewer failures, test plots of these experimental crops must be studied in real-world environments with minimal invasion to determine how they will perform in full-scale agricultural settings. To monitor these crops without interfering with their natural growth, a noninvasive sensor system has been implemented. This system, instituted by the College of Agricultural Sciences and Natural Resources at the University of Nebraska - Lincoln (UNL), uses a system of poles, cables, and winches to support and maneuver a sensor platform above the crops at an outdoor phenotyping site. In this work, we improve upon the UNL outdoor phenotyping system presenting the concept design for a mobile, cable-driven phenotyping system as opposed to a permanent phenotyping facility. One major challenge in large-scale, cable-driven robots is stability of the end-effector. As a result, this mobile system seeks to use a novel method of end-effector stabilization using an onboard rotor drive system, herein referred to as the Instrument Platform Aeromotive Stabilization System (IPASS). A prototype system is developed and analyzed to determine the viability of IPASS.

A zebrafish model of chordoma initiated by notochord-driven expression of HRASV12.

PubMed

Burger, Alexa; Vasilyev, Aleksandr; Tomar, Ritu; Selig, Martin K; Nielsen, G Petur; Peterson, Randall T; Drummond, Iain A; Haber, Daniel A

2014-07-01

Chordoma is a malignant tumor thought to arise from remnants of the embryonic notochord, with its origin in the bones of the axial skeleton. Surgical resection is the standard treatment, usually in combination with radiation therapy, but neither chemotherapeutic nor targeted therapeutic approaches have demonstrated success. No animal model and only few chordoma cell lines are available for preclinical drug testing, and, although no druggable genetic drivers have been identified, activation of EGFR and downstream AKT-PI3K pathways have been described. Here, we report a zebrafish model of chordoma, based on stable transgene-driven expression of HRASV12 in notochord cells during development. Extensive intra-notochordal tumor formation is evident within days of transgene expression, ultimately leading to larval death. The zebrafish tumors share characteristics of human chordoma as demonstrated by immunohistochemistry and electron microscopy. The mTORC1 inhibitor rapamycin, which has some demonstrated activity in a chordoma cell line, delays the onset of tumor formation in our zebrafish model, and improves survival of tumor-bearing fish. Consequently, the HRASV12-driven zebrafish model of chordoma could enable high-throughput screening of potential therapeutic agents for the treatment of this refractory cancer. © 2014. Published by The Company of Biologists Ltd.