Sideband instability analysis based on a one-dimensional high-gain free electron laser model

NASA Astrophysics Data System (ADS)

Tsai, Cheng-Ying; Wu, Juhao; Yang, Chuan; Yoon, Moohyun; Zhou, Guanqun

2017-12-01

When an untapered high-gain free electron laser (FEL) reaches saturation, the exponential growth ceases and the radiation power starts to oscillate about an equilibrium. The FEL radiation power or efficiency can be increased by undulator tapering. For a high-gain tapered FEL, although the power is enhanced after the first saturation, it is known that there is a so-called second saturation where the FEL power growth stops even with a tapered undulator system. The sideband instability is one of the primary reasons leading to this second saturation. In this paper, we provide a quantitative analysis on how the gradient of undulator tapering can mitigate the sideband growth. The study is carried out semianalytically and compared with one-dimensional numerical simulations. The physical parameters are taken from Linac Coherent Light Source-like electron bunch and undulator systems. The sideband field gain and the evolution of the radiation spectra for different gradients of undulator tapering are examined. It is found that a strong undulator tapering (˜10 %) provides effective suppression of the sideband instability in the postsaturation regime.

Rational design of hypoallergens applied to the major cat allergen Fel d 1.

PubMed

Saarne, T; Kaiser, L; Grönlund, H; Rasool, O; Gafvelin, G; van Hage-Hamsten, M

2005-05-01

Allergen-specific immunotherapy is the only treatment for allergic disease providing long-lasting symptom relief. Currently, it is mainly based on the use of crude allergen extracts. The treatment may be improved by the use of genetically engineered allergens, hypoallergens, aiming at a more effective and safer therapy. The aim of this study was to provide a rational design of hypoallergen candidates for immunotherapy by using structural information and knowledge of B and T cell epitopes of an allergen. The three-dimensional structure of the major cat allergen Fel d 1 was systematically altered by duplication of selected T cell epitopes and disruption of disulphide bonds. Seven Fel d 1 derivatives were generated and screened for allergenic reactivity in comparison with recombinant Fel d 1 in competition-ELISA. The allergenicity was further evaluated in basophil activation experiments and T cell reactivity was assessed in a lymphoproliferation assay. Three out of seven Fel d 1 derivatives, with two duplicated T cell epitopes and one or two disulphide bonds disrupted, were carefully evaluated. The three derivatives displayed a strong reduction in allergenicity with 400-900 times lower IgE-binding capacity than recombinant Fel d 1. In addition, they induced a lower degree of basophil activation and similar or stronger T cell proliferation than recombinant Fel d 1. By a rational approach, we have constructed three Fel d 1 hypoallergens with reduced IgE-binding capacities and retained T cell reactivities. This strategy may be applied to any well-characterized allergen to improve immunotherapy for allergic patients.

Application of nonlinear models to estimate the gain of one-dimensional free-electron lasers

NASA Astrophysics Data System (ADS)

Peter, E.; Rizzato, F. B.; Endler, A.

2017-06-01

In the present work, we make use of simplified nonlinear models based on the compressibility factor (Peter et al., Phys. Plasmas, vol. 20 (12), 2013, 123104) to predict the gain of one-dimensional (1-D) free-electron lasers (FELs), considering space-charge and thermal effects. These models proved to be reasonable to estimate some aspects of 1-D FEL theory, such as the position of the onset of mixing, in the case of a initially cold electron beam, and the position of the breakdown of the laminar regime, in the case of an initially warm beam (Peter et al., Phys. Plasmas, vol. 21 (11), 2014, 113104). The results given by the models are compared to wave-particle simulations showing a reasonable agreement.

Generation of double pulses at the Shanghai soft X-ray free electron laser facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Zhen; Feng, Chao; Gu, Qiang

2017-01-28

In this paper, we present the promise of a new method generating double electron pulses with the picosecond-scale pulse length and the tunable interpulse spacing at several picoseconds, which has been witnessed an impressive potential of application in pump-probe techniques, two-color X-ray free electron laser (FEL), high-gradient witness bunch acceleration in a plasma, etc. Three-dimensional simulations are carried out to analyze the dynamic of the electron beam in the linear accelerator. Some comparisons have been made between the new method and the existing ways as well.

Statistical properties of radiation from VUV and X-ray free electron laser

NASA Astrophysics Data System (ADS)

Saldin, E. L.; Schneidmiller, E. A.; Yurkov, M. V.

1998-03-01

The paper presents a comprehensive analysis of the statistical properties of the radiation from a self-amplified spontaneous emission (SASE) free electron laser operating in linear and nonlinear mode. The investigation has been performed in a one-dimensional approximation assuming the electron pulse length to be much larger than a coherence length of the radiation. The following statistical properties of the SASE FEL radiation have been studied in detail: time and spectral field correlations, distribution of the fluctuations of the instantaneous radiation power, distribution of the energy in the electron bunch, distribution of the radiation energy after the monochromator installed at the FEL amplifier exit and radiation spectrum. The linear high gain limit is studied analytically. It is shown that the radiation from a SASE FEL operating in the linear regime possesses all the features corresponding to completely chaotic polarized radiation. A detailed study of statistical properties of the radiation from a SASE FEL operating in linear and nonlinear regime has been performed by means of time-dependent simulation codes. All numerical results presented in the paper have been calculated for the 70 nm SASE FEL at the TESLA Test Facility being under construction at DESY.

Three-Dimensional Reconstruction of the Giant Mimivirus Particle with an X-Ray Free-Electron Laser (CXIDB ID 30)

DOE Data Explorer

Ekeberg, Tomas

2015-05-26

This dataset contains the diffraction patterns that were used for the first three-dimensional reconstruction of a virus using FEL data. The sample was the giant mimivirus particle, which is one of the largest known viruses with a diameter of 450 nm. The dataset consists of the 198 diffraction patterns that were used in the analysis.

How Adequate are One- and Two-Dimensional Free Energy Landscapes for Protein Folding Dynamics?

NASA Astrophysics Data System (ADS)

Maisuradze, Gia G.; Liwo, Adam; Scheraga, Harold A.

2009-06-01

The molecular dynamics trajectories of protein folding or unfolding, generated with the coarse-grained united-residue force field for the B domain of staphylococcal protein A, were analyzed by principal component analysis (PCA). The folding or unfolding process was examined by using free-energy landscapes (FELs) in PC space. By introducing a novel multidimensional FEL, it was shown that the low-dimensional FELs are not always sufficient for the description of folding or unfolding processes. Similarities between the topographies of FELs along low- and high-indexed principal components were observed.

Algorithm for loading shot noise microbunching in multi-dimensional, free-electron laser simulation codes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fawley, William M.

We discuss the underlying reasoning behind and the details of the numerical algorithm used in the GINGER free-electron laser(FEL) simulation code to load the initial shot noise microbunching on the electron beam. In particular, we point out that there are some additional subtleties which must be followed for multi-dimensional codes which are not necessary for one-dimensional formulations. Moreover, requiring that the higher harmonics of the microbunching also be properly initialized with the correct statistics leads to additional complexities. We present some numerical results including the predicted incoherent, spontaneous emission as tests of the shot noise algorithm's correctness.

Emerging opportunities in structural biology with X-ray free-electron lasers

PubMed Central

Schlichting, Ilme; Miao, Jianwei

2012-01-01

X-ray free-electron lasers (X-FELs) produce X-ray pulses with extremely brilliant peak intensity and ultrashort pulse duration. It has been proposed that radiation damage can be “outrun” by using an ultra intense and short X-FEL pulse that passes a biological sample before the onset of significant radiation damage. The concept of “diffraction-before-destruction” has been demonstrated recently at the Linac Coherent Light Source, the first operational hard X-ray FEL, for protein nanocrystals and giant virus particles. The continuous diffraction patterns from single particles allow solving the classical “phase problem” by the oversampling method with iterative algorithms. If enough data are collected from many identical copies of a (biological) particle, its three-dimensional structure can be reconstructed. We review the current status and future prospects of serial femtosecond crystallography (SFX) and single-particle coherent diffraction imaging (CDI) with X-FELs. PMID:22922042

Formation of disulfide bonds and homodimers of the major cat allergen Fel d 1 equivalent to the natural allergen by expression in Escherichia coli.

PubMed

Grönlund, Hans; Bergman, Tomas; Sandström, Kristofer; Alvelius, Gunvor; Reininger, Renate; Verdino, Petra; Hauswirth, Alexander; Liderot, Karin; Valent, Peter; Spitzauer, Susanne; Keller, Walter; Valenta, Rudolf; van Hage-Hamsten, Marianne

2003-10-10

Dander from the domestic cat (Felis domesticus) is one of the most common causes of IgE-mediated allergy. Attempts to produce tetrameric folded major allergen Fel d 1 by recombinant methods with structural features similar to the natural allergen have been only partially successful. In this study, a recombinant folded Fel d 1 with molecular and biological properties similar to the natural counterpart was produced. A synthetic gene coding for direct fusion of the Fel d 1 chain 2 N-terminally to chain 1 was constructed by overlapping oligonucleotides in PCR. Escherichia coli expression resulted in a non-covalently associated homodimer with an apparent molecular mass of 30 kDa defined by size exclusion chromatography. Furthermore, each 19,177-Da subunit displayed a disulfide pattern identical to that found in the natural Fel d 1, i.e. Cys3(1) Cys73(2), Cys44(1)-Cys48(2), Cys70(1)-Cys7(2), as determined by electrospray mass spectrometry after tryptic digestion. Circular dichroism analysis showed identical folds of natural and recombinant Fel d 1. Furthermore, recombinant Fel d l reacted specifically with serum IgE, inducing expression of CD203c on basophils and lymphoproliferative responses in cat-allergic patients. The results show that the overall fold and immunological properties of the recombinant Fel d 1 are very similar to those of natural Fel d 1. Moreover, the recombinant Fel d 1 construct provides a tool for defining the three-dimensional structure of Fel d 1 and represents a reagent for diagnosis and allergen-specific immunotherapy of cat allergy.

MITHRA 1.0: A full-wave simulation tool for free electron lasers

NASA Astrophysics Data System (ADS)

Fallahi, Arya; Yahaghi, Alireza; Kärtner, Franz X.

2018-07-01

Free Electron Lasers (FELs) are a solution for providing intense, coherent and bright radiation in the hard X-ray regime. Due to the low wall-plug efficiency of FEL facilities, it is crucial and additionally very useful to develop complete and accurate simulation tools for better optimizing a FEL interaction. The highly sophisticated dynamics involved in a FEL process was the main obstacle hindering the development of general simulation tools for this problem. We present a numerical algorithm based on finite difference time domain/Particle in cell (FDTD/PIC) in a Lorentz boosted coordinate system which is able to fulfill a full-wave simulation of a FEL process. The developed software offers a suitable tool for the analysis of FEL interactions without considering any of the usual approximations. A coordinate transformation to bunch rest frame makes the very different length scales of bunch size, optical wavelengths and the undulator period transform to values with the same order. Consequently, FDTD/PIC simulations in conjunction with efficient parallelization techniques make the full-wave simulation feasible using the available computational resources. Several examples of free electron lasers are analyzed using the developed software, the results are benchmarked based on standard FEL codes and discussed in detail.

Feasibility study of generating ultra-high harmonic radiation with a single stage echo-enabled harmonic generation scheme

NASA Astrophysics Data System (ADS)

Zhou, Kaishang; Feng, Chao; Wang, Dong

2016-10-01

The echo enabled harmonic generation (EEHG) scheme holds the ability for the generation of fully coherent soft x-ray free-electron laser (FEL) pulses directly from external UV seeding sources. In this paper, we study the feasibility of using a single stage EEHG to generate coherent radiation in the "water window" and beyond. Using the high-order operating modes of the EEHG scheme, intensive numerical simulations have been performed considering various three-dimensional effects. The simulation results demonstrated that coherent soft x-ray radiation at 150th harmonic (1.77 nm) of the seed can be produced by a single stage EEHG. The decreasing of the final bunching factor at the desired harmonic caused by intra beam scattering (IBS) effect has also been analyzed.

Single-shot diffraction data from the Mimivirus particle using an X-ray free-electron laser.

PubMed

Ekeberg, Tomas; Svenda, Martin; Seibert, M Marvin; Abergel, Chantal; Maia, Filipe R N C; Seltzer, Virginie; DePonte, Daniel P; Aquila, Andrew; Andreasson, Jakob; Iwan, Bianca; Jönsson, Olof; Westphal, Daniel; Odić, Duško; Andersson, Inger; Barty, Anton; Liang, Meng; Martin, Andrew V; Gumprecht, Lars; Fleckenstein, Holger; Bajt, Saša; Barthelmess, Miriam; Coppola, Nicola; Claverie, Jean-Michel; Loh, N Duane; Bostedt, Christoph; Bozek, John D; Krzywinski, Jacek; Messerschmidt, Marc; Bogan, Michael J; Hampton, Christina Y; Sierra, Raymond G; Frank, Matthias; Shoeman, Robert L; Lomb, Lukas; Foucar, Lutz; Epp, Sascha W; Rolles, Daniel; Rudenko, Artem; Hartmann, Robert; Hartmann, Andreas; Kimmel, Nils; Holl, Peter; Weidenspointner, Georg; Rudek, Benedikt; Erk, Benjamin; Kassemeyer, Stephan; Schlichting, Ilme; Strüder, Lothar; Ullrich, Joachim; Schmidt, Carlo; Krasniqi, Faton; Hauser, Günter; Reich, Christian; Soltau, Heike; Schorb, Sebastian; Hirsemann, Helmut; Wunderer, Cornelia; Graafsma, Heinz; Chapman, Henry; Hajdu, Janos

2016-08-01

Free-electron lasers (FEL) hold the potential to revolutionize structural biology by producing X-ray pules short enough to outrun radiation damage, thus allowing imaging of biological samples without the limitation from radiation damage. Thus, a major part of the scientific case for the first FELs was three-dimensional (3D) reconstruction of non-crystalline biological objects. In a recent publication we demonstrated the first 3D reconstruction of a biological object from an X-ray FEL using this technique. The sample was the giant Mimivirus, which is one of the largest known viruses with a diameter of 450 nm. Here we present the dataset used for this successful reconstruction. Data-analysis methods for single-particle imaging at FELs are undergoing heavy development but data collection relies on very limited time available through a highly competitive proposal process. This dataset provides experimental data to the entire community and could boost algorithm development and provide a benchmark dataset for new algorithms.

Single-shot diffraction data from the Mimivirus particle using an X-ray free-electron laser

NASA Astrophysics Data System (ADS)

Ekeberg, Tomas; Svenda, Martin; Seibert, M. Marvin; Abergel, Chantal; Maia, Filipe R. N. C.; Seltzer, Virginie; Deponte, Daniel P.; Aquila, Andrew; Andreasson, Jakob; Iwan, Bianca; Jönsson, Olof; Westphal, Daniel; Odić, Duško; Andersson, Inger; Barty, Anton; Liang, Meng; Martin, Andrew V.; Gumprecht, Lars; Fleckenstein, Holger; Bajt, Saša; Barthelmess, Miriam; Coppola, Nicola; Claverie, Jean-Michel; Loh, N. Duane; Bostedt, Christoph; Bozek, John D.; Krzywinski, Jacek; Messerschmidt, Marc; Bogan, Michael J.; Hampton, Christina Y.; Sierra, Raymond G.; Frank, Matthias; Shoeman, Robert L.; Lomb, Lukas; Foucar, Lutz; Epp, Sascha W.; Rolles, Daniel; Rudenko, Artem; Hartmann, Robert; Hartmann, Andreas; Kimmel, Nils; Holl, Peter; Weidenspointner, Georg; Rudek, Benedikt; Erk, Benjamin; Kassemeyer, Stephan; Schlichting, Ilme; Strüder, Lothar; Ullrich, Joachim; Schmidt, Carlo; Krasniqi, Faton; Hauser, Günter; Reich, Christian; Soltau, Heike; Schorb, Sebastian; Hirsemann, Helmut; Wunderer, Cornelia; Graafsma, Heinz; Chapman, Henry; Hajdu, Janos

2016-08-01

Free-electron lasers (FEL) hold the potential to revolutionize structural biology by producing X-ray pules short enough to outrun radiation damage, thus allowing imaging of biological samples without the limitation from radiation damage. Thus, a major part of the scientific case for the first FELs was three-dimensional (3D) reconstruction of non-crystalline biological objects. In a recent publication we demonstrated the first 3D reconstruction of a biological object from an X-ray FEL using this technique. The sample was the giant Mimivirus, which is one of the largest known viruses with a diameter of 450 nm. Here we present the dataset used for this successful reconstruction. Data-analysis methods for single-particle imaging at FELs are undergoing heavy development but data collection relies on very limited time available through a highly competitive proposal process. This dataset provides experimental data to the entire community and could boost algorithm development and provide a benchmark dataset for new algorithms.

Status report on the NIST-NRL free electron laser

NASA Astrophysics Data System (ADS)

Philip, Debenham; Robert, Ayres; Wayne, Cassatt A.; Carol Johnson, B.; Ronald, Johnson G.; Eric, Lindstrom L.; Paul, Liposky J.; Anthony, Marella B.; David, Mohr L.; Julian, Whittaker K.; Neil, Wilkin D.; Mark, Wilson A. D.; Tang, Cha-Mei; Sprangle, Phillip; Penner, Samuel

1991-07-01

A free electron laser (FEL) user facility is being constructed at the National Institute of Standards and Technology (NIST) in collaboration with the Naval Research Laboratory (NRL). The FEL, which will be operated as an oscillator, will be driven by the 17 to 185 MeV electron beam of the NIST continuous-wave racetrack microtron. Anticipated performance of the FEL includes: wavelength tuneable from 200 nm to 10 μm, a continuous train of 3 ps pulses at either 16.5 or 66.1 MHz, and average power of 10 to 200 W. Construction of the RTM will be completed in May, 1991. The 3.64 m long undulator is assembled at the factory and is scheduled to be delivered in February, 1991. The measured rms field error is 0.6%, which is sufficiently small for good gain. Due to the broad tuning range, the use of lasers to align the cavity end mirrors is impractical. With a full-scale model of the 9 m long optical cavity, we have developed a method of aligning the mirrors to the required accuracy using white light and an autocollimator/telescope. We have performed three-dimensional simulations of performance including the effects of the electron beam (emittance, pulse length and shape, and timing jitter), undulator field errors, and cavity losses. These calculations predict adequate gain for lasing across the full wavelength range. Additional calculations are underway to predict the performance at saturation.

Free-electron laser simulations on the MPP

NASA Technical Reports Server (NTRS)

Vonlaven, Scott A.; Liebrock, Lorie M.

1987-01-01

Free electron lasers (FELs) are of interest because they provide high power, high efficiency, and broad tunability. FEL simulations can make efficient use of computers of the Massively Parallel Processor (MPP) class because most of the processing consists of applying a simple equation to a set of identical particles. A test version of the KMS Fusion FEL simulation, which resides mainly in the MPPs host computer and only partially in the MPP, has run successfully.

STUDIES OF A FREE ELECTRON LASER DRIVEN BY A LASER-PLASMA ACCELERATOR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Montgomery, A.; Schroeder, C.; Fawley, W.

A free electron laser (FEL) uses an undulator, a set of alternating magnets producing a periodic magnetic fi eld, to stimulate emission of coherent radiation from a relativistic electron beam. The Lasers, Optical Accelerator Systems Integrated Studies (LOASIS) group at Lawrence Berkeley National Laboratory (LBNL) will use an innovative laserplasma wakefi eld accelerator to produce an electron beam to drive a proposed FEL. In order to optimize the FEL performance, the dependence on electron beam and undulator parameters must be understood. Numerical modeling of the FEL using the simulation code GINGER predicts the experimental results for given input parameters. Amongmore » the parameters studied were electron beam energy spread, emittance, and mismatch with the undulator focusing. Vacuum-chamber wakefi elds were also simulated to study their effect on FEL performance. Energy spread was found to be the most infl uential factor, with output FEL radiation power sharply decreasing for relative energy spreads greater than 0.33%. Vacuum chamber wakefi elds and beam mismatch had little effect on the simulated LOASIS FEL at the currents considered. This study concludes that continued improvement of the laser-plasma wakefi eld accelerator electron beam will allow the LOASIS FEL to operate in an optimal regime, producing high-quality XUV and x-ray pulses.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bahrdt, J.; Frentrup, W.; Gaupp, A.

BESSY plans to build a SASE-FEL facility for the energy range from 20 eV to 1000 eV. The energy range will be covered by three APPLE II type undulators with a magnetic length of about 60 m each. This paper summarizes the basic parameters of the FEL-undulators. The magnetic design will be presented. A modified APPLE II design will be discussed which provides higher fields at the expense of reduced horizontal access. GENESIS simulations give an estimate on the tolerances for the beam wander and for gap errors.

Analysis of Shot Noise Suppression for Electron Beams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ratner, Daniel; /Stanford U., Appl. Phys. Dept.; Huang, Zhirong

2012-05-07

Shot noise can affect the performance of free-electron lasers (FELs) by driving instabilities (e.g., the microbunching instability) or by competing with seeded density modulations. Recent papers have proposed suppressing shot noise to enhance FEL performance. In this paper we use a one-dimensional (1D) model to calculate the noise amplification from an energy modulation (e.g., electron interactions from space charge or undulator radiation) followed by a dispersive section. We show that, for a broad class of interactions, selecting the correct dispersive strength suppresses shot noise across a wide range of frequencies. The final noise level depends on the beam's energy spreadmore » and the properties of the interaction potential. We confirm and illustrate our analytical results with 1D simulations.« less

Study of Storage Ring Free-Electron Laser Using Experimental and Simulation Approaches

NASA Astrophysics Data System (ADS)

Jia, Botao

2011-12-01

The Duke electron storage ring, first commissioned in November of 1994, has been developed as a dedicated driver for storage ring free-electron lasers (SRFELs) operating in a wide wavelength range from infrared, to visible, to ultraviolet (UV) and vacuum ultraviolet (VUV). The storage ring has a long straight section for various insertion devices and can be operated in a wide energy range (0.25 GeV to 1.15 GeV). Commissioned in 1995, the first free-electron laser (FEL) on the Duke storage ring was the OK-4 FEL, an optical klystron with two planar undulators sandwiching a buncher magnet. In 2005, the OK-5 FEL with two helical undulators was commissioned. Operating four undulators---two OK-4 and two OK-5 undulators, the world's first distributed optical klystron FEL was brought to operation in 2005. Via Compton scattering of FEL photons and electrons in the storage ring, the Duke FEL drives the world's most powerful, nearly monochromatic, and polarized Compton gamma-ray source, the High Intensity Gamma-ray Source (HIgammaS). Today, a variety of configurations of the storage ring FELs at Duke have been used in a wide range of research areas from nuclear physics to biophysics, from chemical and medical research to industrial applications. The capability of accurately measuring the storage ring electron beam energy spread is crucial for understanding the longitudinal beam dynamics and the dynamics of the storage ring FEL. In this dissertation, we have successfully developed a noninvasive, versatile, and accurate method to measure the energy spread using optical klystron radiation. Novel numerical methods based upon the Gauss-Hermite expansion have been developed to treat both spectral broadening and modulation on an equal footing. Through properly configuring the optical klystron, this energy spread measurement method has a large dynamic range. In addition, a model-based scheme has been developed for correcting the electron beam emittance related inhomogeneous spectral broadening effect, to further enhance the accuracy of measuring the electron beam energy spread. Taking advantage of the direct measurement method of the electron beam energy spread, we have developed another novel technique to simultaneously measure the FEL power, electron beam energy spread, and other beam parameters. This allowed us to study the FEL power in a systematic manner for the first time. Based on the experimental findings and results of the theoretical predictions, we have proposed a compact formula to predict the FEL power using only the knowledge of electron beam current, beam energy, and bunch length. As part of the dissertation work, we have developed a self-consistent numerical model to study the storage ring FEL. The simulation program models the electron beam propagation along the storage ring, multi-turn FEL interaction in the undulators, gradual intra-cavity optical power buildup, etc. This simulation code captures the main features of a storage ring FEL at different time and space scales. The simulated FEL gain has been benchmarked against measured gain and calculated gain with good agreement. The simulation package can provide comprehensive information about the FEL gain, optical pulse growth, electron beam properties, etc. In the near future, we plan to further improve the simulation model, by including additional physics effects such as microwave instability, to make it a more useful tool for FEL research.

Time-dependent multi-dimensional simulation studies of the electron output scheme for high power FELs

NASA Astrophysics Data System (ADS)

Hahn, S. J.; Fawley, W. M.; Kim, K. J.; Edighoffer, J. A.

1994-12-01

The authors examine the performance of the so-called electron output scheme recently proposed by the Novosibirsk group. In this scheme, the key role of the FEL oscillator is to induce bunching, while an external undulator, called the radiator, then outcouples the bunched electron beam to optical energy via coherent emission. The level of the intracavity power in the oscillator is kept low by employing a transverse optical klystron (TOK) configuration, thus avoiding excessive thermal loading on the cavity mirrors. Time-dependent effects are important in the operation of the electron output scheme because high gain in the TOK oscillator leads to sideband instabilities and chaotic behavior. The authors have carried out an extensive simulation study by using 1D and 2D time-dependent codes and find that proper control of the oscillator cavity detuning and cavity loss results in high output bunching with a narrow spectral bandwidth. Large cavity detuning in the oscillator and tapering of the radiator undulator is necessary for the optimum output power.

Statistical properties of the radiation from SASE FEL operating in the linear regime

NASA Astrophysics Data System (ADS)

Saldin, E. L.; Schneidmiller, E. A.; Yurkov, M. V.

1998-02-01

The paper presents comprehensive analysis of statistical properties of the radiation from self amplified spontaneous emission (SASE) free electron laser operating in linear mode. The investigation has been performed in a one-dimensional approximation, assuming the electron pulse length to be much larger than a coherence length of the radiation. The following statistical properties of the SASE FEL radiation have been studied: field correlations, distribution of the radiation energy after monochromator installed at the FEL amplifier exit and photoelectric counting statistics of SASE FEL radiation. It is shown that the radiation from SASE FEL operating in linear regime possesses all the features corresponding to completely chaotic polarized radiation.

Compact single-pass X-ray FEL with harmonic multiplication cascades

NASA Astrophysics Data System (ADS)

Zhukovsky, K.

2018-07-01

The generation of X-ray radiation in cascaded single-pass free electron laser (FEL), which amplifies high harmonics of a two-frequency undulator, is studied. Power dynamics of FEL harmonics is explored with the help of the phenomenological model of a single pass FEL. The model describes both linear and non-linear harmonic generation, starting from a coherent seed laser and initial shot noise with account for main loss factors for each harmonic in each cascade individually: the energy spread and beam divergence, the coupling losses between FEL cascades, the diffraction etc. The model was validated with the experiment and with relevant 3-D simulations. It is employed for modeling the cascaded FELs with harmonic multiplication and analyzing the evolution of FEL harmonic power with the aim to obtain the maximum high harmonic power in the X-ray band at the shortest possible FEL length with the lowest possible seed frequency. The advantages of two-frequency undulators in HGHG FELs are elucidated. The requirements for the electron beam are studied; the need for low energy spread is evidenced: our evaluations yield σe < 2 × 10-4. Several cascaded HGHG FELs with two-frequency undulators are modeled. Generation of soft X-ray radiation at λ = 2 . 71 nm, reaching ∼50 MW power with I0 ∼ 100 A in a cascaded FEL at just 40 m with 13.51 nm seed, matching peak reflectivity of Mo/Si, is demonstrated. The generation of 40 MW radiation power at λ = 2 . 27 nm with the beam current I0 ∼ 100 A, energy E = 950 MeV and the energy spread σe = 2 × 10-4 is studied, using second and third harmonics in three-stage 45 m long FEL. The multistage FEL is modeled for generating radiation in nanometer band: ∼40 MW power at λ ∼ 2 . 6 nm with I0 ∼ 175 A current in just ∼40 m long FEL with commercially available F2 excimer UV laser seed at 157 nm. The peak radiation power rises to ∼0.5 GW for ∼1 kA beam current.

The APS SASE FEL : modeling and code comparison.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Biedron, S. G.

A self-amplified spontaneous emission (SASE) free-electron laser (FEL) is under construction at the Advanced Photon Source (APS). Five FEL simulation codes were used in the design phase: GENESIS, GINGER, MEDUSA, RON, and TDA3D. Initial comparisons between each of these independent formulations show good agreement for the parameters of the APS SASE FEL.

Multiscale molecular dynamics simulations of rotary motor proteins.

PubMed

Ekimoto, Toru; Ikeguchi, Mitsunori

2018-04-01

Protein functions require specific structures frequently coupled with conformational changes. The scale of the structural dynamics of proteins spans from the atomic to the molecular level. Theoretically, all-atom molecular dynamics (MD) simulation is a powerful tool to investigate protein dynamics because the MD simulation is capable of capturing conformational changes obeying the intrinsically structural features. However, to study long-timescale dynamics, efficient sampling techniques and coarse-grained (CG) approaches coupled with all-atom MD simulations, termed multiscale MD simulations, are required to overcome the timescale limitation in all-atom MD simulations. Here, we review two examples of rotary motor proteins examined using free energy landscape (FEL) analysis and CG-MD simulations. In the FEL analysis, FEL is calculated as a function of reaction coordinates, and the long-timescale dynamics corresponding to conformational changes is described as transitions on the FEL surface. Another approach is the utilization of the CG model, in which the CG parameters are tuned using the fluctuation matching methodology with all-atom MD simulations. The long-timespan dynamics is then elucidated straightforwardly by using CG-MD simulations.

Generation and Amplification of Coherent Radiation with Optical Orbital Angular Momentum in a Free-Electron Laser

NASA Astrophysics Data System (ADS)

Hemsing, Erik Willard

The object of this work is to examine how coherent light that carries orbital angular momentum (OAM) can be generated and amplified in a single pass, high-gain free-electron laser (FEL) at the fundamental operating frequency. This concept unites two rapidly expanding, but at present largely non-overlapping fields of study: high-order OAM light modes, which interact in new ways with matter, and FELs, in which a relativistically energetic electron beam emits coherent, ultra high-brightness, highly frequency-tunable light. The ability to generate OAM light in an FEL enables new regimes of laser interaction physics to be explored at wavelengths down to hard x-rays. The theoretical portion of this dissertation attempts to provide a new predictive mathematical framework. It builds on existing work, and describes the three-dimensional electromagnetic field of the high-gain FEL as a sum of OAM modes such that the amplification properties of individual modes can be characterized. The effects of uncorrelated energy spread, longitudinal space charge, energy detuning, and transverse emittance in the electron beam are included, as is the diffraction of the laser light. Theoretical predictions are corroborated by detailed numerical Genesis 1.3 simulations. When the theory is extended to frequency harmonics, a novel interaction is uncovered that generates a helical electron beam density distribution. These predictions are also supported by numerical Tredi simulations. This type of highly correlated structure is shown to naturally emit OAM light, and forms the basis of a new high-gain, high-mode generation (HGHMG) scheme proposed in its entirety here. The experimental section examines the helical microbunching concept in a proof-of-principle experiment dubbed HELIX, performed at the UCLA Neptune laboratory. We present detailed measurement of the coherent transition radiation emitted by the 12.5 MeV electron beam that is microbunched in a second harmonic interaction with an input laser and helical undulator. The predicted dependence of the CTR signal on the input laser polarization is observed, and is consistent with microbunching that has a periodicity near the 10.6 mum wavelength of the 30 MW CO2 laser pulse. Scans of the interaction energy bandwidth are consistent with predictions that indicate a dominant azimuthal density mode with a bunching factor of 10%, and thus provide indication of the first experimental evidence of helical microbunching. This result offers support for future successful realization of the proposed HGHMG scheme to generate OAM modes in high-gain FELs.

Distributed seeding for narrow-line width hard x-ray free-electron lasers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, Dinh Cong; Anisimov, Petr Mikhaylovich; Buechler, Cynthia Eileen

2015-09-09

We describe a new FEL line-narrowing technique called distributed seeding (DS), using Si(111) Bragg crystal monochromators to enhance the spectral brightness of the MaRIE hard X-ray freeelectron laser. DS differs from self-seeding in three important aspects. First, DS relies on spectral filtering of the radiation at multiple locations along the undulator, with a monochromator located every few power gain lengths. Second, DS performs filtering early in the exponential gain region before SASE spikes start to appear in the radiation longitudinal profile. Third, DS provides the option to select a wavelength longer than the peak of the SASE gain curve, whichmore » leads to improved spectral contrast of the seeded FEL over the SASE background. Timedependent Genesis simulations show the power-vs-z growth curves for DS exhibit behaviors of a seeded FEL amplifier, such as exponential growth region immediately after the filters. Of the seeding approaches considered, the two-stage DS spectra produce the highest contrast of seeded FEL over the SASE background and that the three-stage DS provides the narrowest linewidth with a relative spectral FWHM of 8 X 10 -5 .« less

Multi-dimensional optimization of a terawatt seeded tapered Free Electron Laser with a Multi-Objective Genetic Algorithm

DOE PAGES

Wu, Juhao; Hu, Newman; Setiawan, Hananiel; ...

2016-11-20

There is a great interest in generating high-power hard X-ray Free Electron Laser (FEL) in the terawatt (TW) level that can enable coherent diffraction imaging of complex molecules like proteins and probe fundamental high-field physics. A feasibility study of producing such X-ray pulses was carried out in this paper employing a configuration beginning with a Self-Amplified Spontaneous Emission FEL, followed by a “self-seeding” crystal monochromator generating a fully coherent seed, and finishing with a long tapered undulator where the coherent seed recombines with the electron bunch and is amplified to high power. The undulator tapering profile, the phase advance inmore » the undulator break sections, the quadrupole focusing strength, etc. are parameters to be optimized. A Genetic Algorithm (GA) is adopted for this multi-dimensional optimization. Concrete examples are given for LINAC Coherent Light Source (LCLS) and LCLS-II-type systems. Finally, analytical estimate is also developed to cross check the simulation and optimization results as a quick and complimentary tool.« less

Simulations of a FIR Oscillator with Large Slippage parameter at Jefferson Lab for FIR/UV pump-probe experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Benson, Stephen V.; Campbell, L. T.; McNeil, B.W.T.

We previously proposed a dual FEL configuration on the UV Demo FEL at Jefferson Lab that would allow simultaneous lasing at FIR and UV wavelengths. The FIR source would be an FEL oscillator with a short wiggler providing diffraction-limited pulses with pulse energy exceeding 50 microJoules, using the exhaust beam from a UVFEL as the input electron beam. Since the UV FEL requires very short pulses, the input to the FIR FEL is extremely short compared to a slippage length and the usual Slowly Varying Envelope Approximation (SVEA) does not apply. We use a non-SVEA code to simulate this systemmore » both with a small energy spread (UV laser off) and with large energy spread (UV laser on).« less

Tapered undulator for SASE FELs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fawley, William M.; Huang, Zhirong; Kim, Kwang-Je

We discuss the use of tapered undulators to enhance the performance of free-electron lasers (FELs) based upon self-amplified spontaneous emission (SASE), where the radiation tends to have a relatively broad bandwidth, limited temporal phase coherence, and large amplitude fluctuations. Using the polychromatic FEL simulation code GINGER, we numerically demonstrate the effectiveness of a tapered undulator for parameters corresponding to the existing Argonne low-energy undulator test line (LEUTL) FEL. We also study possible tapering options for proposed x-ray FELs such as the Linac Coherent Light Source (LCLS).

Brightness analysis of an electron beam with a complex profile

NASA Astrophysics Data System (ADS)

Maesaka, Hirokazu; Hara, Toru; Togawa, Kazuaki; Inagaki, Takahiro; Tanaka, Hitoshi

2018-05-01

We propose a novel analysis method to obtain the core bright part of an electron beam with a complex phase-space profile. This method is beneficial to evaluate the performance of simulation data of a linear accelerator (linac), such as an x-ray free electron laser (XFEL) machine, since the phase-space distribution of a linac electron beam is not simple, compared to a Gaussian beam in a synchrotron. In this analysis, the brightness of undulator radiation is calculated and the core of an electron beam is determined by maximizing the brightness. We successfully extracted core electrons from a complex beam profile of XFEL simulation data, which was not expressed by a set of slice parameters. FEL simulations showed that the FEL intensity was well remained even after extracting the core part. Consequently, the FEL performance can be estimated by this analysis without time-consuming FEL simulations.

The efficiency of photovoltaic cells exposed to pulsed laser light

NASA Technical Reports Server (NTRS)

Lowe, R. A.; Landis, G. A.; Jenkins, P.

1993-01-01

Future space missions may use laser power beaming systems with a free electron laser (FEL) to transmit light to a photovoltaic array receiver. To investigate the efficiency of solar cells with pulsed laser light, several types of GaAs, Si, CuInSe2, and GaSb cells were tested with the simulated pulse format of the induction and radio frequency (RF) FEL. The induction pulse format was simulated with an 800-watt average power copper vapor laser and the RF format with a frequency-doubled mode-locked Nd:YAG laser. Averaged current vs bias voltage measurements for each cell were taken at various optical power levels and the efficiency measured at the maximum power point. Experimental results show that the conversion efficiency for the cells tested is highly dependent on cell minority carrier lifetime, the width and frequency of the pulses, load impedance, and the average incident power. Three main effects were found to decrease the efficiency of solar cells exposed to simulated FEL illumination: cell series resistance, LC 'ringing', and output inductance. Improvements in efficiency were achieved by modifying the frequency response of the cell to match the spectral energy content of the laser pulse with external passive components.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Murokh, A.

VISA (Visible to Infrared SASE Amplifier) is a high-gain self-amplified spontaneous emission FEL, which achieved saturation at 840 nm within a single-pass 4-m undulator. A gain length shorter than 18 cm has been obtained, yielding the gain of 2 x 10{sup 8} at saturation. The FEL performance, including spectral, angular, and statistical properties of SASE radiation, has been characterized for different electron beam conditions. The results are compared to 3-D SASE FEL theory and start-to-end numerical simulations of the entire injector, transport, and FEL system. Detailed agreement between simulations and experimental results is obtained over the wide range of themore » electron beam parameters.« less

Experimental and DFT simulation study of a novel felodipine cocrystal: Characterization, dissolving properties and thermal decomposition kinetics.

PubMed

Yang, Caiqin; Guo, Wei; Lin, Yulong; Lin, Qianqian; Wang, Jiaojiao; Wang, Jing; Zeng, Yanli

2018-05-30

In this study, a new cocrystal of felodipine (Fel) and glutaric acid (Glu) with a high dissolution rate was developed using the solvent ultrasonic method. The prepared cocrystal was characterized using X-ray powder diffraction, differential scanning calorimetry, thermogravimetric (TG) analysis, and infrared (IR) spectroscopy. To provide basic information about the optimization of pharmaceutical preparations of Fel-based cocrystals, this work investigated the thermal decomposition kinetics of the Fel-Glu cocrystal through non-isothermal thermogravimetry. Density functional theory (DFT) simulations were also performed on the Fel monomer and the trimolecular cocrystal compound for exploring the mechanisms underlying hydrogen bonding formation and thermal decomposition. Combined results of IR spectroscopy and DFT simulation verified that the Fel-Glu cocrystal formed via the NH⋯OC and CO⋯HO hydrogen bonds between Fel and Glu at the ratio of 1:2. The TG/derivative TG curves indicated that the thermal decomposition of the Fel-Glu cocrystal underwent a two-step process. The apparent activation energy (E a ) and pre-exponential factor (A) of the thermal decomposition for the first stage were 84.90 kJ mol -1 and 7.03 × 10 7  min -1 , respectively. The mechanism underlying thermal decomposition possibly involved nucleation and growth, with the integral mechanism function G(α) of α 3/2 . DFT calculation revealed that the hydrogen bonding between Fel and Glu weakened the terminal methoxyl, methyl, and ethyl groups in the Fel molecule. As a result, these groups were lost along with the Glu molecule in the first thermal decomposition. In conclusion, the formed cocrystal exhibited different thermal decomposition kinetics and showed different E a , A, and shelf life from the intact active pharmaceutical ingredient. Copyright © 2018 Elsevier B.V. All rights reserved.

40 CFR 86.004-30 - Certification.

Code of Federal Regulations, 2011 CFR

2011-07-01

... simulation of such, resulting in an increase of 1.5 times the NMHC+NOX standard or FEL above the NMHC+NOX... simulation of such, resulting in exhaust emissions exceeding 1.5 times the applicable standard or FEL for... catastrophically failed, or an electronic simulation of such. (2)(i) Otto-cycle. An engine misfire condition is...

40 CFR 86.004-30 - Certification.

Code of Federal Regulations, 2014 CFR

2014-07-01

... simulation of such, resulting in an increase of 1.5 times the NMHC+NOX standard or FEL above the NMHC+NOX... simulation of such, resulting in exhaust emissions exceeding 1.5 times the applicable standard or FEL for... catastrophically failed, or an electronic simulation of such. (2)(i) Otto-cycle. An engine misfire condition is...

Start-Up of FEL Oscillator from Shot Noise

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kumar, V.; Krishnagopal, S.; Fawley, W.M.

In free-electron laser (FEL) oscillators, as inself-amplified spontaneous emission (SASE) FELs, the buildup of cavitypower starts from shot noise resulting from the discreteness ofelectronic charge. It is important to do the start-up analysis for thebuild-up of cavity power in order to fix the macropulse width from theelectron accelerator such that the system reaches saturation. In thispaper, we use the time-dependent simulation code GINGER [1]toperformthis analysis. We present results of this analysis for theparameters of the Compact Ultrafast TErahertz FEL (CUTE-FEL) [2]beingbuilt atRRCAT.

Component-resolved microarray analysis of IgE sensitization profiles to Felis catus major allergen molecules in Russian cat-allergic patients.

PubMed

Dolgova, Anna Sergeevna; Sudina, Anna Evgenevna; Cherkashina, Anna Sergeevna; Stukolova, Olga Alekseevna

We aimed to determine the profile of IgE reactivity to three major cat allergens, Fel d 1, Fel d 2 and Fel d 4, in cat-allergic patients in the Moscow region in Russia. sIgE levels to recombinant proteins expressed in Escherichia coli (Fel d 1 and Fel d 4) and to Fel d 2 protein purified from cat serum were measured using a microarray method developed in our laboratory. Sera from 174 anonymous subjects with a positive reaction (≥0.35 IU/mL) to cat dander extract (e1, ImmunoCAP) and 56 negative controls were used for IgE testing. Fel d 1 was recognized by 92.5%, Fel d 2 by 29.9% and Fel d 4 by 39.1% of the tested patient sera. The sensitivity to these three proteins was approximately 98% compared to cat dander extract (correlation coefficient to ImmunoCAP is 0.94 with PPV = 0.99 and NPV = 0.95). These predictive values appeared to be even more statistically significant than the divergence between the ISAC IgE test and the extract-based singleplex ImmunoCAP. The combination of the three investigated proteins (Fel d 1, Fel d 2 and Fel d 4) is suitable for in vitro molecular (serological) diagnosis of cat allergy in this region as a complement to cat dander extract. Moreover, with this method, we found distinction between Fel d 2 and other Feline sIgEs formation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

WATANABE, T.; LIU, D.; MURPHY, J.B.

The strong focusing VISA undulator is presented in this report. The proposed FEL will operate at the 1 {micro}m water window. Extensive simulations were performed to optimize an FEL amplifier based on the two-meter long VISA undulator which has a period of 1.8 cm and an undulator parameter K = 1.26. The betatron function inside the VISA undulator is about 30 cm. For an electron beam with a peak current {approx}1 kA and a normalized emittance of 5 mm-mrad, the FEL peak power can exceed 1 GW within the 2 m VISA undulator using a 5 kW peak power seedmore » laser. Such a device can produce a megawatt of average power for a 700 MHz rep rate. The transverse distribution of the FEL radiation along the undulator, as well as after the undulator, is explored by numerical simulation. The FEL power density at 5 m downstream from the undulator is less than 100 kW/cm{sup 2} for this MW-class FEL. We will also discuss the feasibility of an experimental demonstration of the laser seeded FEL amplifier based on the 2-m VISA undulator at the NSLS Source Development Lab (SDL).« less

Terahertz Free Electron Laser: Design, Simulation and Analysis

DTIC Science & Technology

2014-12-01

34 1. GINGER ...and Combination Magnets .........................................72 a. GINGER Results...wavelength using GINGER FEL code for the Niowave FEL parameters. ...............................................................................40

GINGER simulations of short-pulse effects in the LEUTL FEL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Z.; Fawley, W.M.

While the long-pulse, coasting beam model is often used in analysis and simulation of self-amplified spontaneous emission (SASE) free-electron lasers (FELs), many current SASE demonstration experiments employ relatively short electron bunches whose pulse length is on the order of the radiation slippage length. In particular, the low-energy undulator test line (LEUTL) FEL at the Advanced Photon Source has recently lased and nominally saturated in both visible and near-ultraviolet wavelength regions with a sub-ps pulse length that is somewhat shorter than the total slippage length in the 22-m undulator system. In this paper we explore several characteristics of the short pulsemore » regime for SASE FELs with the multidimensional, time-dependent simulation code GINGER, concentrating on making a direct comparison with the experimental results from LEUTL. Items of interest include the radiation gain length, pulse energy, saturation position, and spectral bandwidth. We address the importance of short-pulse effects when scaling the LEUTL results to proposed x-ray FELs and also briefly discuss the possible importance of coherent spontaneous emission at startup.« less

Pulsed laser illumination of photovoltaic cells

NASA Technical Reports Server (NTRS)

Yater, Jane A.; Lowe, Roland A.; Jenkins, Phillip P.; Landis, Geoffrey A.

1994-01-01

In future space missions, free electron lasers (FEL) may be used to illuminate photovoltaic array receivers to provide remote power. Both the radio-frequency (RF) and induction FEL provide FEL produce pulsed rather than continuous output. In this work we investigate cell response to pulsed laser light which simulates the RF FEL format. The results indicate that if the pulse repetition is high, cell efficiencies are only slightly reduced compared to constant illumination at the same wavelength. The frequency response of the cells is weak, with both voltage and current outputs essentially dc in nature. Comparison with previous experiments indicates that the RF FEL pulse format yields more efficient photovoltaic conversion than does an induction FEL pulse format.

Free electron lasers for transmission of energy in space

NASA Technical Reports Server (NTRS)

Segall, S. B.; Hiddleston, H. R.; Catella, G. C.

1981-01-01

A one-dimensional resonant-particle model of a free electron laser (FEL) is used to calculate laser gain and conversion efficiency of electron energy to photon energy. The optical beam profile for a resonant optical cavity is included in the model as an axial variation of laser intensity. The electron beam profile is matched to the optical beam profile and modeled as an axial variation of current density. Effective energy spread due to beam emittance is included. Accelerators appropriate for a space-based FEL oscillator are reviewed. Constraints on the concentric optical resonator and on systems required for space operation are described. An example is given of a space-based FEL that would produce 1.7 MW of average output power at 0.5 micrometer wavelength with over 50% conversion efficiency of electrical energy to laser energy. It would utilize a 10 m-long amplifier centered in a 200 m-long optical cavity. A 3-amp, 65 meV electrostatic accelerator would provide the electron beam and recover the beam after it passes through the amplifier. Three to five shuttle flights would be needed to place the laser in orbit.

Dispersion relations for 1D high-gain FELs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Webb, S.D.; Litvinenko, V.N.

2010-08-23

We present analytical results for the one-dimensional dispersion relation for high-gain FELs. Using kappa-n distributions, we obtain analytical relations between the dispersion relations for various order kappa distributions. Since an exact solution exists for the kappa-1 (Lorentzian) distribution, this provides some insight into the number of modes on the way to the Gaussian distribution.

Tunable Soft X-Ray Oscillators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wurtele, Jonathan; Gandhi, Punut; Gu, X-W

A concept for a tunable soft x-ray free electron laser (FEL) photon source is presented and studied numerically. The concept is based on echo-enabled harmonic generation (EEHG), wherein two modulator-chicane sections impose high harmonic structure with much greater efficacy as compared to conventional high harmonic FELs that use only one modulator-chicane section. The idea proposed here is to replace the external laser power sources in the EEHG modulators with FEL oscillators, and to combine the bunching of the beam with the production of radiation. Tunability is accomplished by adjusting the magnetic chicanes while the two oscillators remain at a fixedmore » frequency. This scheme eliminates the need to develop coherent sources with the requisite power, pulse length, and stability requirements by exploiting the MHz bunch repetition rates of FEL continuous wave (CW) sources driven by superconducting (SC) linacs. We present time-dependent GINGER simulation results for an EEHG scheme with an oscillator modulator at 43 nm employing 50percent reflective dielectric mirrors and a second modulator employing an external, 215-nm drive laser. Peak output of order 300 MW is obtained at 2.7 nm, corresponding to the 80th harmonic of 215 nm. An alternative single-cavity echo-oscillator scheme based on a 13.4 nm oscillator is investigated with time-independent simulations that a 180-MW peak power at final wavelength of 1.12 nm. Three alternate configurations that use separate bunches to produce the radiation for EEHG microbunching are also presented. Our results show that oscillator-based soft x-ray FELs driven by CWSC linacs are extremely attractive because of their potential to produce tunable radiation at high average power together with excellent longitudinal coherence and narrow spectral bandwidth.« less

Characterization of an 800 nm SASE FEL at Saturation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nuhn, Heinz-Dieter

2002-11-13

VISA (Visible to Infrared SASE Amplifier) is an FEL (Free Electron Laser) designed to saturate at a radiation wavelength of 800 nm within a 4-m long, strong focusing undulator. Large gain is achieved by driving the FEL with the 72 MeV, high brightness beam of BNL's Accelerator Test Facility (ATF). We present measurements that demonstrate saturation in addition to the frequency spectrum of the FEL radiation. Energy, gain length and spectral characteristics are compared and shown to agree with simulation and theoretical predictions.

Novosibirsk Free Electron Laser: Recent Achievements and Future Prospects

NASA Astrophysics Data System (ADS)

Shevchenko, O. A.; Arbuzov, V. S.; Vinokurov, N. A.; Vobly, P. D.; Volkov, V. N.; Getmanov, Ya. V.; Davidyuk, I. V.; Deychuly, O. I.; Dementyev, E. N.; Dovzhenko, B. A.; Knyazev, B. A.; Kolobanov, E. I.; Kondakov, A. A.; Kozak, V. R.; Kozyrev, E. V.; Kubarev, V. V.; Kulipanov, G. N.; Kuper, E. A.; Kuptsov, I. V.; Kurkin, G. Ya.; Krutikhin, S. A.; Medvedev, L. E.; Motygin, S. V.; Ovchar, V. K.; Osipov, V. N.; Petrov, V. M.; Pilan, A. M.; Popik, V. M.; Repkov, V. V.; Salikova, T. V.; Sedlyarov, I. K.; Serednyakov, S. S.; Skrinsky, A. N.; Tararyshkin, S. V.; Tribendis, A. G.; Cheskidov, V. G.; Chernov, K. N.; Shcheglov, M. A.

2017-01-01

Free electron lasers (FELs) are unique sources of electromagnetic radiation with tunable wavelength. A high-power FEL has been created at the G. I.Budker Institute for Nuclear Physics. Its radiation frequency can be tuned over a wide range in the terahertz and infrared spectral ranges. As the source of electron bunches, this FEL uses a multi-turn energy-recovery linac, which has five straight sections. Three sections are used for three FELs which operate in different wavelength ranges (90-240 μm for the first, 37-80 μm for the second, and 5-20 μm for the third ones). The first and the second FELs were commissioned in 2003 and 2009, respectively. They are used for various applied and research problems now. The third FEL is installed on the last, forth accelerator loop, in which the electron energy is the maximum. It comprises three undulator sections and a 40 m optical cavity. The first lasing of this FEL was obtained in the summer of 2015. The radiation wavelength was 9 μm and the average power was about 100 W. The design power is 1 kW at a pulse repetition rate of 3.75 MHz. Radiation of the third FEL will be delivered to user stations from the protected hall in the near future. The third FEL commissioning results are presented and the current status of the first and second FELs as well as their future development prospects are described.

Plasma channel undulator excited by high-order laser modes

DOE PAGES

Wang, J. W.; Schroeder, C. B.; Li, R.; ...

2017-12-04

The possibility of utilizing plasma undulators and plasma accelerators to produce compact ultraviolet and X-ray sources, has attracted considerable interest for a few decades. This interest has been driven by the great potential to decrease the threshold for accessing such sources, which are mainly provided by a few dedicated large-scale synchrotron or free-electron laser (FEL) facilities. However, the broad radiation bandwidth of such plasma devices limits the source brightness and makes it difficult for the FEL instability to develop. Here in this paper, using multi-dimensional particle-in-cell (PIC) simulations, we demonstrate that a plasma undulator generated by the beating of amore » mixture of high-order laser modes propagating inside a plasma channel, leads to a few percent radiation bandwidth. The strength of the undulator can reach unity, the period can be less than a millimeter, and the number of undulator periods can be significantly increased by a phase locking technique based on the longitudinal tapering. Polarization control of such an undulator can be achieved by appropriately choosing the phase of the modes. According to our results, in the fully beam loaded regime, the electron current in the plasma undulator can reach 0.3 kA level, making such an undulator a potential candidate towards a table-Top FEL.« less

Plasma channel undulator excited by high-order laser modes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, J. W.; Schroeder, C. B.; Li, R.

The possibility of utilizing plasma undulators and plasma accelerators to produce compact ultraviolet and X-ray sources, has attracted considerable interest for a few decades. This interest has been driven by the great potential to decrease the threshold for accessing such sources, which are mainly provided by a few dedicated large-scale synchrotron or free-electron laser (FEL) facilities. However, the broad radiation bandwidth of such plasma devices limits the source brightness and makes it difficult for the FEL instability to develop. Here in this paper, using multi-dimensional particle-in-cell (PIC) simulations, we demonstrate that a plasma undulator generated by the beating of amore » mixture of high-order laser modes propagating inside a plasma channel, leads to a few percent radiation bandwidth. The strength of the undulator can reach unity, the period can be less than a millimeter, and the number of undulator periods can be significantly increased by a phase locking technique based on the longitudinal tapering. Polarization control of such an undulator can be achieved by appropriately choosing the phase of the modes. According to our results, in the fully beam loaded regime, the electron current in the plasma undulator can reach 0.3 kA level, making such an undulator a potential candidate towards a table-Top FEL.« less

Time-dependent multi-dimensional simulation studies of the electron output scheme for high power FELs

NASA Astrophysics Data System (ADS)

Hahn, S. J.; Fawley, W. M.; Kim, K.-J.; Edighoffer, J. A.

1995-04-01

We examine the performance of the so-called electron output scheme recently proposed by the Novosibirsk group [G.I. Erg et al., 15th Int. Free Electron Laser Conf., The Hague, The Netherlands, 1993, Book of Abstracts p. 50; Preprint Budker INP 93-75]. In this scheme, the key role of the FEL oscillator is to induce bunching, while an external undulator, called the radiator, then outcouples the bunched electron beam to optical energy via coherent emission. The level of the intracavity power in the oscillator is kept low by employing a transverse optical klystron (TOK) configuration, thus avoiding excessive thermal loading on the cavity mirrors. Time-dependent effects are important in the operation of the electron output scheme because high gain in the TOK oscillator leads to sideband instabilities and chaotic behavior. We have carried out an extensive simulation study by using 1D and 2D time-dependent codes and find that proper control of the oscillator cavity detuning and cavity loss results in high output bunching with a narrow spectral bandwidth. Large cavity detuning in the oscillator and tapering of the radiator undulator is necessary for the optimum output power.

Pulsed laser illumination of photovoltaic cells

NASA Technical Reports Server (NTRS)

Yater, Jane A.; Lowe, Roland A.; Jenkins, Phillip P.; Landis, Geoffrey A.

1995-01-01

In future space missions, free electron lasers (FEL) may be used to illuminate photovoltaic receivers to provide remote power. Both the radio-frequency (RF) and induction FEL produce pulsed rather than continuous output. In this work we investigate cell response to pulsed laser light which simulates the RF FEL format. The results indicate that if the pulse repetition is high, cell efficiencies are only slightly reduced compared to constant illumination at the same wavelength. The frequency response of the cells is weak, with both voltage and current outputs essentially dc in nature. Comparison with previous experiments indicates that the RF FEL pulse format yields more efficient photovoltaic conversion than does an induction FEL format.

Simulation of free-electron lasers seeded with broadband radiation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bajlekov, Svetoslav; Fawley, William; Schroeder, Carl

2011-03-10

The longitudinal coherence of free-electron laser (FEL) radiation can be enhanced by seeding the FEL with high harmonics of an optical laser pulse. The radiation produced by high-harmonic generation (HHG), however, has a fast-varying temporal profile that can violate the slowly varying envelope approximation and limited frequency window that is employed in conventional free-electron laser simulation codes. Here we investigate the implications of violating this approximation on the accuracy of simulations. On the basis of both analytical considerations and 1D numerical studies, it is concluded that, for most realistic scenarios, conventional FEL codes are capable of accurately simulating the FELmore » process even when the seed radiation violates the slowly varying envelope approximation. We additionally discuss the significance of filtering the harmonic content of broadband HHG seeds.« less

A Smoluchowski model of crystallization dynamics of small colloidal clusters

NASA Astrophysics Data System (ADS)

Beltran-Villegas, Daniel J.; Sehgal, Ray M.; Maroudas, Dimitrios; Ford, David M.; Bevan, Michael A.

2011-10-01

We investigate the dynamics of colloidal crystallization in a 32-particle system at a fixed value of interparticle depletion attraction that produces coexisting fluid and solid phases. Free energy landscapes (FELs) and diffusivity landscapes (DLs) are obtained as coefficients of 1D Smoluchowski equations using as order parameters either the radius of gyration or the average crystallinity. FELs and DLs are estimated by fitting the Smoluchowski equations to Brownian dynamics (BD) simulations using either linear fits to locally initiated trajectories or global fits to unbiased trajectories using Bayesian inference. The resulting FELs are compared to Monte Carlo Umbrella Sampling results. The accuracy of the FELs and DLs for modeling colloidal crystallization dynamics is evaluated by comparing mean first-passage times from BD simulations with analytical predictions using the FEL and DL models. While the 1D models accurately capture dynamics near the free energy minimum fluid and crystal configurations, predictions near the transition region are not quantitatively accurate. A preliminary investigation of ensemble averaged 2D order parameter trajectories suggests that 2D models are required to capture crystallization dynamics in the transition region.

Optimization Studies of the FERMI at ELETTRA FEL Design

DOE Office of Scientific and Technical Information (OSTI.GOV)

De Ninno, Giovanni; Fawley, William M.; Penn, Gregory E.

The FERMI at ELETTRA project at Sincotrone Trieste involves two FEL's, each based upon the principle of seeded harmonic generation and using the existing ELETTRA injection linac at 1.2 GeV beam energy. Scheduled to be completed in 2008, FEL-1 will operate in 40-100 nm wavelength range and will involve one stage of harmonic up-conversion. The second undulator line, FEL-2, will begin operation two years later in the 10-40 nm wavelength range and use two harmonic stages operating as a cascade. The FEL design assumes continuous wavelength tunability over the full wavelength range, and polarization tunability of the output radiation includingmore » vertical or horizontal linear as well as helical polarization. The design considers focusing properties and segmentation of realizable undulators and available input seed lasers. We review the studies that have led to our current design. We present results of simulations using GENESIS and GINGER simulation codes including studies of various shot-to-shot fluctuations and undulator errors. Findings for the expected output radiation in terms of the power, transverse and longitudinal coherence are reported.« less

FEL amplifier performance in the Compton regime

NASA Astrophysics Data System (ADS)

Cover, R. A.; Bhowmik, A.

1984-01-01

The Kroll-Morton-Rosenbluth equations of motion for electrons in a linearly polarized, tapered wiggler are utilized to describe gain in free-electron laser amplifiers. The three-dimensional amplifier model includes the effects of density variation in the electron beam, off-axis variations in the wiggler magnetic field, and betatron oscillations. The input electromagnetic field is injected and subsequently propagated within the wiggler by computing the Fresnel-Kirchhoff diffraction integral using the Gardner-Fresnel-Kirchhoff algorithm. The injected optical beam used in evaluating amplifier performance is initially a Gaussian which in general may be astigmatic. The importance of the above effects on extraction efficiency is computed both with rigorous three-dimensional electromagnetic wave propagation and a Gaussian treatment of the field.

The analysis of single-electron orbits in a free electron laser based upon a rectangular hybrid wiggler

NASA Astrophysics Data System (ADS)

Kordbacheh, A.; Ghahremaninezhad, Roghayeh; Maraghechi, B.

2012-09-01

A three-dimensional analysis of a novel free-electron laser (FEL) based upon a rectangular hybrid wiggler (RHW) is presented. This RHW is designed in a configuration composed of rectangular rings with alternating ferrite and dielectric spacers immersed in a solenoidal magnetic field. An analytic model of RHW is introduced by solution of Laplace's equation for the magnetostatic fields under the appropriate boundary conditions. The single-electron orbits in combined RHW and axial guide magnetic fields are studied when only the first and the third spatial harmonic components of the RHW field are taken into account and the higher order terms are ignored. The results indicate that the third spatial harmonic leads to group III orbits with a strong negative mass regime particularly in large solenoidal magnetic fields. RHW is found to be a promising candidate with favorable characteristics to be used in microwave FEL.

Optimization of the LCLS X-Ray FEL Output Performance in the Presence of Strong Undulator Wakefields

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reiche, S.; /UCLA; Bane, K.L.F.

The Linac Coherent Light Source (LCLS) Free-Electron Laser will operate in the wavelength range of 1.5 to 15 Angstroms. Energy loss due to wakefields within the long undulator can degrade the FEL process by detuning the resonant FEL frequency. The wakefields arise from the vacuum chamber wall resistivity, its surface roughness, and abrupt changes in its aperture. For LCLS parameters, the resistive component is the most critical and depends upon the chamber material (e.g. Cu) and its radius. To study the expected performance in the presence of these wakefields, we make a series of start-to-end simulations with tracking codes PARMELAmore » and ELEGANT and time-dependent FEL simulation codes Genesis 1.3 and Ginger. We discuss the impact of the wakefield on output energy, spectral bandwidth, and temporal envelope of the output FEL pulse, as well as the benefits of a partial compensation obtained with a slight z dependent taper in the undulator field. We compare these results to those obtained by decreasing the bunch charge or increasing the vacuum chamber radius. We also compare our results to those predicted in concurrent analytical work.« less

Coherence and linewidth studies of a 4-nm high power FEL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fawley, W.M.; Sessler, A.M.; Scharlemann, E.T.

Recently the SSRL/SLAC and its collaborators elsewhere have considered the merits of a 2 to 4-nm high power FEL utilizing the SLAC linac electron beam. The FEL would be a single pass amplifier excited by spontaneous emission rather than an oscillator, in order to eliminate the need for a soft X-ray resonant cavity. We have used GINGER, a multifrequency 2D FEL simulation code, to study the expected linewidth and coherence properties of the FEL, in both the exponential and saturated gain regimes. We present results concerning the effective shot noise input power and mode shape, the expected subpercent output linemore » widths, photon flux, and the field temporal and spatial correlation functions. We also discuss the effects of tapering the wiggler upon the output power and line width.« less

A Test of Superradiance in an FEL Experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boyce, R

We describe the design of an FEL Amplifier Test Experiment (FATE)1 to demonstrate the superradiant short bunch regime of a Free Electron Laser in the 1-3 {micro}m wavelength range starting from noise. The relevance to the LCLS X-ray FEL [1] proposal is discussed and numerical simulations are shown. It is numerically demonstrated for the first time with the 2-D code GINGER, that clean-up of noise in the superradiant regime occurs even at low power levels.

Free-electron laser wavelength-selective materials alteration and photoexcitation spectroscopy

NASA Astrophysics Data System (ADS)

Tolk, N. H.; Albridge, R. G.; Barnes, A. V.; Barnes, B. M.; Davidson, J. L.; Gordon, V. D.; Margaritondo, G.; McKinley, J. T.; Mensing, G. A.; Sturmann, J.

1996-10-01

The free-electron laser (FEL) has become an important tool for producing high-intensity photon beams, especially in the infrared. Synchrotron radiation's primary spectral domains are in the ultraviolet and X-ray region. FEL's are therefore excellent complimentary facilities to synchrotron radiation sources. While FEL's have seen only limited use in experimentation, recently developed programs at Vanderbilt University in Nashville, TN, are swiftly rectifying this situation. This review paper examines practical experience obtained through pioneering programs using the Vanderbilt FEL, which currently hosts one of the largest FEL materials research programs. Results will be discussed in three areas: two-photon absorption in germanium, FEL-assisted internal photoemission measurements of interface energy barriers (FELIPE), and wavelength-specific laser diamond ablation.

Design of sub-Angstrom compact free-electron laser source

NASA Astrophysics Data System (ADS)

Bonifacio, Rodolfo; Fares, Hesham; Ferrario, Massimo; McNeil, Brian W. J.; Robb, Gordon R. M.

2017-01-01

In this paper, we propose for first time practical parameters to construct a compact sub-Angstrom Free Electron Laser (FEL) based on Compton backscattering. Our recipe is based on using picocoulomb electron bunch, enabling very low emittance and ultracold electron beam. We assume the FEL is operating in a quantum regime of Self Amplified Spontaneous Emission (SASE). The fundamental quantum feature is a significantly narrower spectrum of the emitted radiation relative to classical SASE. The quantum regime of the SASE FEL is reached when the momentum spread of the electron beam is smaller than the photon recoil momentum. Following the formulae describing SASE FEL operation, realistic designs for quantum FEL experiments are proposed. We discuss the practical constraints that influence the experimental parameters. Numerical simulations of power spectra and intensities are presented and attractive radiation characteristics such as high flux, narrow linewidth, and short pulse structure are demonstrated.

LCLS X-Ray FEL Output Performance in the Presence of Highly Time-Dependent Undulator Wakefields

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fawley, W.M.; /LBL, Berkeley; Bane, K.L.F.

Energy loss due to wakefields within a long undulator, if not compensated by an appropriate tapering of the magnetic field strength, can degrade the FEL process by detuning the resonant FEL frequency. The wakefields arise from the vacuum chamber wall resistivity, its surface roughness, and abrupt changes in its aperture. For LCLS parameters, the resistive-wall component is the most critical and depends upon the chamber material (e.g., Cu) and its radius. Of recent interest[1] is the so-called ''AC'' component of the resistive-wall wake which can lead to strong variations on very short timescales (e.g., {approx} 20 fs). To study themore » expected performance of the LCLS in the presence of these wakefields, we have made an extensive series of start-to-end SASE simulations with tracking codes PARMELA and ELEGANT, and time-dependent FEL simulation codes GENESIS1.3 and GINGER. We discuss the impact of the wakefield losses upon output energy, spectral bandwidth, and temporal envelope of the output FEL pulse, as well as the benefits of a partial compensation of the time-dependent wake losses obtained with a slight z-dependent taper in the undulator field. We compare the taper results to those predicted analytically[2].« less

LCLS X-Ray FEL Output Performance in the Presence of HighlyTime-Dependent Undulator Wakefields

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bane, Karl L.F.; Emma, Paul; Huang, Heinz-Dieter Nuhn

Energy loss due to wakefields within a long undulator, if not compensated by an appropriate tapering of the magnetic field strength, can degrade the FEL process by detuning the resonant FEL frequency. The wakefields arise from the vacuum chamber wall resistivity, its surface roughness, and abrupt changes in its aperture. For LCLS parameters, the resistive-wall component is the most critical and depends upon the chamber material (e.g., Cu) and its radius. Of recent interest[1] is the so-called ''AC'' component of the resistive-wall wake which can lead to strong variations on very short timescales (e.g., {approx} 20 0fs). To study themore » expected performance of the LCLS in the presence of these wakefields, we have made an extensive series of start-to-end SASE simulations with tracking codes PARMELA and ELEGANT, and time-dependent FEL simulation codes GENESIS1.3 and GINGER. We discuss the impact of the wakefield losses upon output energy, spectral bandwidth, and temporal envelope of the output FEL pulse, as well as the benefits of a partial compensation of the time-dependent wake losses obtained with a slight z-dependent taper in the undulator field. We compare the taper results to those predicted analytically[2].« less

Theoretical and simulation studies of seeding methods

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pellegrini, Claudio

We report the theoretical and experimental studies done with the support of DOE-Grant DE-SC0009983 to increase an X-ray FEL peak power from the present level of 20 to 40 GW to one or more TW by seeding, undulator tapering and using the new concept of the Double Bunch FEL.

Simulation Studies of the X-Ray Free-Electron Laser Oscillator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lindberg, R. R.; Shyd'ko, Y.; Kim, K.-J

Simulations of the x-ray free-electron laser (FEL) oscillator are presented that include transverse effects and realistic Bragg crystal properties with the two-dimensional code GINGER. In the present cases considered the radiation divergence is much narrower than the crystal acceptance, and the numerical algorithm can be simplified by ignoring the finite angular bandwidth of the crystal. In this regime GINGER shows that the saturated x-ray pulses have 109 photons and are nearly Fourier-limited with peak powers in excess of 1 MW. Wealso include preliminary results for a four-mirror cavity that can be tuned in wavelength over a few percent, with futuremore » plans to incorporate the full transverse response of the Bragg crystals into GINGER to more accurately model this tunable source.« less

Few-cycle pulse generation in an x-ray free-electron laser.

PubMed

Dunning, D J; McNeil, B W J; Thompson, N R

2013-03-08

A method is proposed to generate trains of few-cycle x-ray pulses from a free-electron laser (FEL) amplifier via a compact "afterburner" extension consisting of several few-period undulator sections separated by electron chicane delays. Simulations show that in the hard x ray (wavelength ~0.1 nm; photon energy ~10 keV) and with peak powers approaching normal FEL saturation (GW) levels, root mean square pulse durations of 700 zs may be obtained. This is approximately two orders of magnitude shorter than that possible for normal FEL amplifier operation. The spectrum is discretely multichromatic with a bandwidth envelope increased by approximately 2 orders of magnitude over unseeded FEL amplifier operation. Such a source would significantly enhance research opportunity in atomic dynamics and push capability toward nuclear dynamics.

Terawatt x-ray free-electron-laser optimization by transverse electron distribution shaping

DOE PAGES

Emma, C.; Wu, J.; Fang, K.; ...

2014-11-03

We study the dependence of the peak power of a 1.5 Å Terawatt (TW), tapered x-ray free-electron laser (FEL) on the transverse electron density distribution. Multidimensional optimization schemes for TW hard x-ray free-electron lasers are applied to the cases of transversely uniform and parabolic electron beam distributions and compared to a Gaussian distribution. The optimizations are performed for a 200 m undulator and a resonant wavelength of λ r = 1.5 Å using the fully three-dimensional FEL particle code GENESIS. The study shows that the flatter transverse electron distributions enhance optical guiding in the tapered section of the undulator andmore » increase the maximum radiation power from a maximum of 1.56 TW for a transversely Gaussian beam to 2.26 TW for the parabolic case and 2.63 TW for the uniform case. Spectral data also shows a 30%–70% reduction in energy deposited in the sidebands for the uniform and parabolic beams compared with a Gaussian. An analysis of the transverse coherence of the radiation shows the coherence area to be much larger than the beam spotsize for all three distributions, making coherent diffraction imaging experiments possible.« less

Coherent Leinard-Wiechert fields produced by FELs (free-electron laser). Technical report, 14 January 1981-13 January 1982

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elias, L.R.

1981-12-01

Results are presented of a three-dimensional numerical analysis of the radiation fields produced in a free-electron laser. The method used here to obtain the spatial and temporal behavior of the radiated fields is based on the coherent superposition of the radiated fields is based on the coherent superposition of the exact Lienard-Wiechert fields produced by each electron in the beam. Interference effects are responsible for the narrow angular radiation patterns obtained and for the high degree of monochromaticity of the radiated fields.

Study of Collective Beam Effects in Energy Recovery Linac Driven Free Electron Lasers

NASA Astrophysics Data System (ADS)

Hall, Christpher C.

Collective beam effects such as coherent synchrotron radiation (CSR) and longitudinal space charge (LSC) can degrade the quality of high-energy electron beams used for applications such as free-electron lasers (FELs). The advent of energy recovery linac (ERL)-based FELs brings exciting possibilities for very high-average current FELs that can operate with greater efficiency. However, due to the structure of ERLs, they may be even more susceptible to CSR. It is therefore necessary that these collective beam effects be well understood if future ERL-based designs are to be successful. The Jefferson Laboratory ERL driven IR FEL provides an ideal test-bed for looking at how CSR impacts the electron beam. Due to its novel design we can easily test how CSR's impact on the beam varies as a function of compression within the machine. In this work we will look at measurements of both average energy loss and energy spectrum fragmentation as a function of bunch compression. These results are compared to particle tracking simulations including a 1D CSR model and, in general, good agreement is seen between simulation and measurement. Of particular interest is fragmentation of the energy spectrum that is observed due to CSR and LSC. We will also show how this fragmentation develops and how it can be mitigated through use of the sextupoles in the JLab FEL. Finally, a more complete 2D model is used to simulate CSR-beam interaction. Due to the parameters of the experiment it is expected that a 2D CSR model would yield different results than the 1D CSR model. However, excellent agreement is seen between the two CSR model results.

Beam dynamics simulations of the injector for a compact THz source

NASA Astrophysics Data System (ADS)

Li, Ji; Pei, Yuan-Ji; Shang, Lei; Feng, Guang-Yao; Hu, Tong-Ning; Chen, Qu-Shan; Li, Cheng-Long

2014-08-01

Terahertz radiation has broad application prospects due to its ability to penetrate deep into many organic materials without the damage caused by ionizing radiations. A free electron laser (FEL)-based THz source is the best choice to produce high-power radiation. In this paper, a 14 MeV injector is introduced for generating high-quality beam for FEL, is composed of an EC-ITC RF gun, compensating coils and a travelling-wave structure. Beam dynamics simulations have been done with ASTRA code to verify the design and to optimize parameters. Simulations of the operating mode at 6 MeV have also been executed.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gündoğan, M. Tural, E-mail: mugetural@yahoo.com; Yavaş, Ö., E-mail: yavas@ankara.edu.tr; Kaya, Ç., E-mail: c.kaya@ankara.edu.tr

Turkish Accelerator and Radiation Laboratory in Ankara (TARLA) facility is proposed as an IR FEL and Bremsstrahlung facility as the first facility of Turkish Accelerator Center (TAC). TARLA is essentially proposed to generate oscillator mode FEL in 3-250 microns wavelengths range, will consist of normal conducting injector system with 250 keV beam energy, two superconducting RF accelerating modules in order to accelerate the beam 15-40 MeV. The TARLA facility is expected to provide two modes, Continuous wave (CW) and pulsed mode. Longitudinal electron bunch length will be changed between 1 and 10 ps. The bunch charge will be limited by 77pC.more » The design of the Button-type Beam Position Monitor for TARLA IR FEL is studied to operate in 1.3 GHz. Mechanical antenna design and simulations are completed considering electron beam parameters of TARLA. Ansoft HFSS and CST Particle Studio is used to compare with results of simulations.« less

A button - type beam position monitor design for TARLA facility

NASA Astrophysics Data System (ADS)

Gündoǧan, M. Tural; Kaya, ć.; Yavaş, Ö.

2016-03-01

Turkish Accelerator and Radiation Laboratory in Ankara (TARLA) facility is proposed as an IR FEL and Bremsstrahlung facility as the first facility of Turkish Accelerator Center (TAC). TARLA is essentially proposed to generate oscillator mode FEL in 3-250 microns wavelengths range, will consist of normal conducting injector system with 250 keV beam energy, two superconducting RF accelerating modules in order to accelerate the beam 15-40 MeV. The TARLA facility is expected to provide two modes, Continuous wave (CW) and pulsed mode. Longitudinal electron bunch length will be changed between 1 and 10 ps. The bunch charge will be limited by 77pC. The design of the Button-type Beam Position Monitor for TARLA IR FEL is studied to operate in 1.3 GHz. Mechanical antenna design and simulations are completed considering electron beam parameters of TARLA. Ansoft HFSS and CST Particle Studio is used to compare with results of simulations.

Optical design of the ARAMIS-beamlines at SwissFEL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Follath, R.; Flechsig, U.; Milne, C.

2016-07-27

SwissFEL is a free electron laser facility for hard and soft X-rays at the Paul Scherrer Institut in Switzerland. The first hard X-ray FEL named ARAMIS will deliver photons in the wavelength range from 1 Å to 7 Å in up to three beamlines alternatively. The beamlines are equipped with crystal monochromators, cover the full wavelength range and offer a variety of operational modes.

INITIAL GAIN MEASUREMENTS OF A 800 NM SASE FEL, VISA.

DOE Office of Scientific and Technical Information (OSTI.GOV)

FRIGOLA,P.; MUROKH,A.; ET AL

2000-08-13

The VISA (Visible to Infrared SASE Amplifier) FEL is designed to obtain high gain at a radiation wavelength of 800nm. The FEL uses the high brightness electron beam of the Accelerator Test Facility (ATF), with energy of 72MeV. VISA uses a novel, 4 m long, strong focusing undulator with a gap of 6mm and a period of 1.8cm. To obtain large gain the beam and undulator axis have to be aligned to better than 50{micro}m. Results from initial measurements on the alignment, gain, and spectrum will be presented and compared to theoretical calculations and simulations.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Murokh, A.; Pellegrini, C.; Rosenzweig, J.

The VISA (Visible to Infrared SASE Amplifier) project is designed to be a SASE-FEL driven to saturation in the sub-micron wavelength region. Its goal is to test various aspects of the existing theory of Self-Amplified Spontaneous Emission, as well as numerical codes. Measurements include: angular and spectral distribution of the FEL light at the exit and inside of the undulator; electron beam micro-bunching using CTR; single-shot time resolved measurements of the pulse profile, using auto-correlation technique and FROG algorithm. The diagnostics are designed to provide maximum information on the physics of the SASE-FEL process, to ensure a close comparison ofmore » the experimental results with theory and simulations.« less

Design and realization of the optical and electron beam alignment system for the HUST-FEL oscillator

NASA Astrophysics Data System (ADS)

Fu, Q.; Tan, P.; Liu, K. F.; Qin, B.; Liu, X.

2018-06-01

A Free Electron Laser(FEL) oscillator with radiation wavelength at 30-100 μ m is under commissioning at Huazhong University of Science and Technology (HUST). This work presents the schematic design and realization procedures for the optical and beam alignment system in the HUST FEL facility. The optical cavity misalignment effects are analyzed with the code OPC + Genesis 1.3, and the tolerance of misalignment is proposed with the simulation result. Depending on undulator mechanical benchmarks, a laser indicating system has been built up as reference datum. The alignment of both optical axis and beam trajectory were achieved by this alignment system.

XFEL OSCILLATOR SIMULATION INCLUDING ANGLE-DEPENDENT CRYSTAL REFLECTIVITY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fawley, William; Lindberg, Ryan; Kim, K-J

The oscillator package within the GINGER FEL simulation code has now been extended to include angle-dependent reflectivity properties of Bragg crystals. Previously, the package was modified to include frequencydependent reflectivity in order to model x-ray FEL oscillators from start-up from shot noise through to saturation. We present a summary of the algorithms used for modeling the crystal reflectivity and radiation propagation outside the undulator, discussing various numerical issues relevant to the domain of high Fresnel number and efficient Hankel transforms. We give some sample XFEL-O simulation results obtained with the angle-dependent reflectivity model, with particular attention directed to the longitudinalmore » and transverse coherence of the radiation output.« less

Embryonic expression of festina lente (fel), a novel maternal gene, in the oligochaete annelid Tubifex tubifex.

PubMed

Nakamura, Takuma; Shiomi, Inori; Shimizu, Takashi

2017-11-01

We have cloned and characterized the expression of a novel maternal gene festina lente (designated Ttu-fel) from the clitellate annelid Tubifex tubifex. Northern blot analyses have shown that Ttu-fel mRNA is approximately 8 kbp in length and that its expression is restricted to oocytes undergoing maturation division and early embryos up to 22-cell stage. Maternal transcripts of Ttu-fel are first detected in oocytes in the ovary of young adults (ca. 40 days after hatching); its expression continues in growing oocytes in the ovisac. Ttu-fel mRNA is distributed broadly throughout the egg undergoing maturation divisions. During the process of ooplasmic segregation that results in the pole plasm formation, Ttu-fel mRNA becomes concentrated to the animal and vegetal poles. The RNA in the animal hemisphere is distributed in a gradient with highest concentration in the cortical region. During the first two cleavages, Ttu-fel mRNA is segregated to CD cell then to D cell; it is subsequently inherited by the three D quadtrant micromeres, 1d, 2d and 3d. Around the time of transition to 22-cell stage, Ttu-fel mRNA becomes undetectable throughout the embryo. Copyright © 2017 Elsevier B.V. All rights reserved.

An optical parametric chirped-pulse amplifier for seeding high repetition rate free-electron lasers

DOE PAGES

Höppner, H.; Hage, A.; Tanikawa, T.; ...

2015-05-15

High repetition rate free-electron lasers (FEL), producing highly intense extreme ultraviolet and x-ray pulses, require new high power tunable femtosecond lasers for FEL seeding and FEL pump-probe experiments. A tunable, 112 W (burst mode) optical parametric chirped-pulse amplifier (OPCPA) is demonstrated with center frequencies ranging from 720–900 nm, pulse energies up to 1.12 mJ and a pulse duration of 30 fs at a repetition rate of 100 kHz. Since the power scalability of this OPCPA is limited by the OPCPA-pump amplifier, we also demonstrate a 6.7–13.7 kW (burst mode) thin-disk OPCPA-pump amplifier, increasing the possible OPCPA output power to manymore » hundreds of watts. Furthermore, third and fourth harmonic generation experiments are performed and the results are used to simulate a seeded FEL with high-gain harmonic generation.« less

Free Energy Landscape - Settlements of Key Residues.

NASA Astrophysics Data System (ADS)

Aroutiounian, Svetlana

2007-03-01

FEL perspective in studies of protein folding transitions reflects notion that since there are ˜10^N conformations to scan in search of lowest free energy state, random search is beyond biological timescale. Protein folding must follow certain fel pathways and folding kinetics of evolutionary selected proteins dominates kinetic traps. Good model for functional robustness of natural proteins - coarse-grained model protein is not very accurate but affords bringing simulations closer to biological realm; Go-like potential secures the fel funnel shape; biochemical contacts signify the funnel bottleneck. Boltzmann-weighted ensemble of protein conformations and histogram method are used to obtain from MC sampling of protein conformational space the approximate probability distribution. The fel is F(rmsd) = -1/βLn[Hist(rmsd)], β=kBT and rmsd is root-mean-square-deviation from native conformation. The sperm whale myoglobin has rich dynamic behavior, is small and large - on computational scale, has a symmetry in architecture and unusual sextet of residue pairs. Main idea: there is a mathematical relation between protein fel and a key residues set providing stability to folding transition. Is the set evolutionary conserved also for functional reasons? Hypothesis: primary sequence determines the key residues positions conserved as stabilizers and the fel is the battlefield for the folding stability. Preliminary results: primary sequence - not the architecture, is the rule settler, indeed.

Development of a novel thermionic RF electron gun applied on a compact THz-FEL facility

NASA Astrophysics Data System (ADS)

Hu, T. N.; Pei, Y. J.; Qin, B.; Liu, K. F.; Feng, G. Y.

2018-04-01

The current requirements from civil and commercial applications lead to the development of compact free-electron laser (FEL)-based terahertz (THz) radiation sources. A picosecond electron gun plays an important role in an FEL-THz facility and attracts significant attention, as machine performance is very sensitive to initial conditions. A novel thermionic gun with an external cathode (EC) and two independently tunable cavities (ITCs) has been found to be a promising alternative to conventional electron sources due to its remarkable characteristics, and correspondingly an FEL injector can achieve a balance between a compact layout and high brightness benefitting from the velocity bunching properties and RF focusing effects in the EC-ITC gun. Nevertheless, the EC-ITC gun has not been extensively examined as part of the FEL injector in the past years. In this regard, to fill this gap, a development focusing on the experimental setup of an FEL injector based on an EC-ITC gun is described in detail. Before assembly, dynamic beam simulations were performed to investigate the optimal mounting position for the Linac associated with the focusing coils, and a suitable radio-frequency (RF) system was established based on a power coupling design and allocation. The testing bench proved to be fully functional through basic experiments using typical diagnostic approaches for estimating primary parameters. Associated with dynamic beam calculations, a performance evaluation for an EC-ITC gun was established while providing indirect testing results for an FEL injector.

A theory for optical wavelength control in short pulse free electron laser oscillators

NASA Astrophysics Data System (ADS)

Wilkenson, Wade F.

1993-06-01

The future safety of the U.S. Navy warship depends on the development of a directed energy self-defense system to keep pace with the ever-improving technology of anti-ship missiles. Two candidates are reviewed. The free electron laser (FEL) has the most advantages, but a chemical laser proposed by TRW is ready for installation on existing ships. Initial testing of issues related to directed energy use at sea can be conducted with the chemical laser. When the technology of the FEL matures, it can replace the chemical laser to provide the best possible defense in the shortest period of time. Continuous tunability is a key advantage of the FEL over the conventional laser. But since the output wavelength is dependent on electron energy, it is subject to random fluctuations originating from the beam source. At the Stanford University Superconducting (SCA) Free Electron Laser (FEL) Facility, the effects are minimized through negative feedback by changing the input electron energy proportional to the observed wavelength drift. The process is simulated by modifying a short pulse FEL numerical program to allow the resonant wavelength to vary over many passes. The physical effects behind optical wavelength control are explained. A theory for the preferential nature of the FEL to follow the resonant wavelength from longer to shorter wavelengths is presented. Finally, the response of the FEL to a rapidly changing resonant wavelength is displayed as a transfer function for the system.

Some issues and subtleties in numerical simulation of X-ray FEL's

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fawley, William M.

Part of the overall design effort for x-ray FEL's such as the LCLS and TESLA projects has involved extensive use of particle simulation codes to predict their output performance and underlying sensitivity to various input parameters (e.g. electron beam emittance). This paper discusses some of the numerical issues that must be addressed by simulation codes in this regime. We first give a brief overview of the standard approximations and simulation methods adopted by time-dependent(i.e. polychromatic) codes such as GINGER, GENESIS, and FAST3D, including the effects of temporal discretization and the resultant limited spectral bandpass,and then discuss the accuracies and inaccuraciesmore » of these codes in predicting incoherent spontaneous emission (i.e. the extremely low gain regime).« less

Experimental Characterization of Nonlinear Harmonic Radiation from a Visible SASE FEL at Saturation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cornacchia, Massimo

2002-08-19

Nonlinear harmonic radiation was observed using the VISA SASE FEL at saturation. The gain lengths, spectra and energies of the three lowest SASE FEL modes were experimentally characterized. Both the measured harmonic gain lengths and center spectral wavelengths are shown to decrease with harmonic number, n, which is consistent with nonlinear harmonic theory. The measured energies for both second and third harmonics are about 1% of the fundamental; the strong second harmonic radiation ({approx} 1 {micro}J) observed is unique for low energy SASE FELs. These experimental results demonstrate for the first time the feasibility of using nonlinear harmonic SASE FELmore » radiation to produce coherent, femtosecond X-rays.« less

Designs and numerical calculations for echo-enabled harmonic generation at very high harmonics

NASA Astrophysics Data System (ADS)

Penn, G.; Reinsch, M.

2011-09-01

The echo-enabled harmonic generation (EEHG) scheme for driving an FEL using two seeded energy modulations at much longer wavelengths than the output wavelength is a promising concept for future seeded FELs. There are many competing requirements in the design of an EEHG beamline which need careful optimization. Furthermore, revised simulation tools and methods are necessary because of both the high harmonic numbers simulated and the complicated nature of the phase space manipulations which are intrinsic to the scheme. This paper explores the constraints on performance and the required tolerances for reaching wavelengths well below 1/100th of that of the seed lasers, and describes some of the methodology for designing such a beamline. Numerical tools, developed both for the GENESIS and GINGER FEL codes, are presented and used here for more accurate study of the scheme beyond a time-averaged model. In particular, the impact of the local structure in peak current and bunching, which is an inherent part of the EEHG scheme, is evaluated.

Amplification of a bi-phase shift-key modulated signal by a mm-wave FEL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prosnitz, D.; Scharlemann, E.T.; Sheaffer, M.K.

Bi-phase shift keying (BPSK) is a modulation scheme used in communications and radar in which the phase of a transmitted rf signal is switched in a coded pattern between discrete values differing by {pi} radians. The transmitted information rate (in communications) or resolution (in imaging radar) depends on the rate at which the transmitted signal can be modulated. Modulation rates of greater than 1 GHz are generally desired. Although the instantaneous gain bandwidth of a mm-wave FEL amplifier can be much greater than 10 GHz, slippage may limit the BPSK modulation rate that can be amplified. Qualitative slippage arguments wouldmore » limit the modulation rate to relatively low values; nevertheless, simulations with a time-dependent FEL code (GINGER) indicate that rates of 2 GHz or more are amplified without much loss in modulation integrity. In this paper we describe the effects of slippage in the simulations and discuss the limits of simple arguments.« less

Effects of finite beam and plasma temperature on the growth rate of a two-stream free electron laser with background plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mahdizadeh, N.; Aghamir, F. M.

2013-02-28

A fluid theory is used to derive the dispersion relation of two-stream free electron laser (TSFEL) with a magnetic planar wiggler pump in the presence of background plasma (BP). The effect of finite beams and plasma temperature on the growth rate of a TSFEL has been verified. The twelve order dispersion equation has been solved numerically. Three instabilities, FEL along with the TS and TS-FEL instabilities occur simultaneously. The analysis in the case of cold BP shows that when the effect of the beam temperature is taken into account, both instable bands of wave-number and peak growth rate in themore » TS instability increase, but peak growth of the FEL and TS-FEL instabilities decreases. Thermal motion of the BP causes to diminish the TS instability and it causes to decrease the FEL and TS-FEL instabilities. By increasing the beam densities and lowering initial velocities (in the collective Raman regime), growth rate of instabilities increases; however, it has opposite behavior in the Campton regime.« less

Pulsed Laser Illumination of Photovoltaic Cells

NASA Technical Reports Server (NTRS)

Yater, Jane A.; Lowe, Roland; Jenkins, Philip; Landis, Geoffrey A.

1994-01-01

In future space missions, free electron lasers (FEL) may be used to illuminate photovoltaic array receivers to provide remote power. The induction FEL and the radio-frequency (RF) FEL both produce pulsed rather than continuous output. In this work, we investigate cell response to pulsed laser light which simulates the RF FEL format, producing 50 ps pulses at a frequency of 78 MHz. A variety of Si, GaAs, CaSb and CdInSe2 (CIS) solar cells are tested at average incident powers between 4 mW/sq cm and 425 mW/sq cm. The results indicate that if the pulse repetition is high, cell efficiencies are only slightly reduced by using a pulsed laser source compared to constant illumination at the same wavelength. Because the pulse separation is less than or approximately equal to the minority carrier lifetime, the illumination conditions are effectively those of a continuous wave laser. The time dependence of the voltage and current response of the cells are also measured using a sampling oscilloscope equipped with a high frequency voltage probe and current transformer. The frequency response of the cells is weak, with both voltage and current outputs essentially dc in nature. Comparison with previous experiments shows that the RF FEL pulse format yields much more efficient photovoltaic conversion of light than does an induction FEL pulse format.

Free-energy landscape, principal component analysis, and structural clustering to identify representative conformations from molecular dynamics simulations: the myoglobin case.

PubMed

Papaleo, Elena; Mereghetti, Paolo; Fantucci, Piercarlo; Grandori, Rita; De Gioia, Luca

2009-01-01

Several molecular dynamics (MD) simulations were used to sample conformations in the neighborhood of the native structure of holo-myoglobin (holo-Mb), collecting trajectories spanning 0.22 micros at 300 K. Principal component (PCA) and free-energy landscape (FEL) analyses, integrated by cluster analysis, which was performed considering the position and structures of the individual helices of the globin fold, were carried out. The coherence between the different structural clusters and the basins of the FEL, together with the convergence of parameters derived by PCA indicates that an accurate description of the Mb conformational space around the native state was achieved by multiple MD trajectories spanning at least 0.14 micros. The integration of FEL, PCA, and structural clustering was shown to be a very useful approach to gain an overall view of the conformational landscape accessible to a protein and to identify representative protein substates. This method could be also used to investigate the conformational and dynamical properties of Mb apo-, mutant, or delete versions, in which greater conformational variability is expected and, therefore identification of representative substates from the simulations is relevant to disclose structure-function relationship.

Another cat and mouse game: Deciphering the evolution of the SCGB superfamily and exploring the molecular similarity of major cat allergen Fel d 1 and mouse ABP using computational approaches

PubMed Central

Pageat, Patrick; Bienboire-Frosini, Cécile

2018-01-01

The mammalian secretoglobin (SCGB) superfamily contains functionally diverse members, among which the major cat allergen Fel d 1 and mouse salivary androgen-binding protein (ABP) display similar subunits. We searched for molecular similarities between Fel d 1 and ABP to examine the possibility that they play similar roles. We aimed to i) cluster the evolutionary relationships of the SCGB superfamily; ii) identify divergence patterns, structural overlap, and protein-protein docking between Fel d 1 and ABP dimers; and iii) explore the residual interaction between ABP dimers and steroid binding in chemical communication using computational approaches. We also report that the evolutionary tree of the SCGB superfamily comprises seven unique palm-like clusters, showing the evolutionary pattern and divergence time tree of Fel d 1 with 28 ABP paralogs. Three ABP subunits (A27, BG27, and BG26) share phylogenetic relationships with Fel d 1 chains. The Fel d 1 and ABP subunits show similarities in terms of sequence conservation, identical motifs and binding site clefts. Topologically equivalent positions were visualized through superimposition of ABP A27:BG27 (AB) and ABP A27:BG26 (AG) dimers on a heterodimeric Fel d 1 model. In docking, Fel d 1-ABP dimers exhibit the maximum surface binding ability of AG compared with that of AB dimers and the several polar interactions between ABP dimers with steroids. Hence, cat Fel d 1 is an ABP-like molecule in which monomeric chains 1 and 2 are the equivalent of the ABPA and ABPBG monomers, respectively. These findings suggest that the biological and molecular function of Fel d 1 is similar to that of ABP in chemical communication, possibly via pheromone and/or steroid binding. PMID:29771985

Another cat and mouse game: Deciphering the evolution of the SCGB superfamily and exploring the molecular similarity of major cat allergen Fel d 1 and mouse ABP using computational approaches.

PubMed

Durairaj, Rajesh; Pageat, Patrick; Bienboire-Frosini, Cécile

2018-01-01

The mammalian secretoglobin (SCGB) superfamily contains functionally diverse members, among which the major cat allergen Fel d 1 and mouse salivary androgen-binding protein (ABP) display similar subunits. We searched for molecular similarities between Fel d 1 and ABP to examine the possibility that they play similar roles. We aimed to i) cluster the evolutionary relationships of the SCGB superfamily; ii) identify divergence patterns, structural overlap, and protein-protein docking between Fel d 1 and ABP dimers; and iii) explore the residual interaction between ABP dimers and steroid binding in chemical communication using computational approaches. We also report that the evolutionary tree of the SCGB superfamily comprises seven unique palm-like clusters, showing the evolutionary pattern and divergence time tree of Fel d 1 with 28 ABP paralogs. Three ABP subunits (A27, BG27, and BG26) share phylogenetic relationships with Fel d 1 chains. The Fel d 1 and ABP subunits show similarities in terms of sequence conservation, identical motifs and binding site clefts. Topologically equivalent positions were visualized through superimposition of ABP A27:BG27 (AB) and ABP A27:BG26 (AG) dimers on a heterodimeric Fel d 1 model. In docking, Fel d 1-ABP dimers exhibit the maximum surface binding ability of AG compared with that of AB dimers and the several polar interactions between ABP dimers with steroids. Hence, cat Fel d 1 is an ABP-like molecule in which monomeric chains 1 and 2 are the equivalent of the ABPA and ABPBG monomers, respectively. These findings suggest that the biological and molecular function of Fel d 1 is similar to that of ABP in chemical communication, possibly via pheromone and/or steroid binding.

JUNGFRAU 0.2: prototype characterization of a gain-switching, high dynamic range imaging system for photon science at SwissFEL and synchrotrons

NASA Astrophysics Data System (ADS)

Jungmann-Smith, J. H.; Bergamaschi, A.; Cartier, S.; Dinapoli, R.; Greiffenberg, D.; Johnson, I.; Maliakal, D.; Mezza, D.; Mozzanica, A.; Ruder, Ch; Schaedler, L.; Schmitt, B.; Shi, X.; Tinti, G.

2014-12-01

JUNGFRAU (adJUstiNg Gain detector FoR the Aramis User station) is a two-dimensional pixel detector for photon science applications at free electron lasers and synchrotron light sources. It is developed for the SwissFEL currently under construction at the Paul Scherrer Institute, Switzerland. Characteristics of this application-specific integrating circuit readout chip include single photon sensitivity and low noise over a dynamic range of over four orders of magnitude of photon input signal. These characteristics are achieved by a three-fold gain-switching preamplifier in each pixel, which automatically adjusts its gain to the amount of charge deposited on the pixel. The final JUNGFRAU chip comprises 256 × 256 pixels of 75 × 75 μm2 each. Arrays of 2 × 4 chips are bump-bonded to monolithic detector modules of about 4 × 8 cm2. Multi-module systems up to 16 Mpixels are planned for the end stations at SwissFEL. A readout rate in excess of 2 kHz is anticipated, which serves the readout requirements of SwissFEL and enables high count rate synchrotron experiments with a linear count rate capability of > 20 MHz/pixel. Promising characterization results from a 3.6 × 3.6 mm2 prototype (JUNGFRAU 0.2) with fluorescence X-ray, infrared laser and synchrotron irradiation are shown. The results include an electronic noise as low as 100 electrons root-mean-square, which enables single photon detection down to X-ray energies of about 2 keV. Noise below the Poisson fluctuation of the photon number and a linearity error of the pixel response of about 1% are demonstrated. First imaging experiments successfully show automatic gain switching. The edge spread function of the imaging system proves to be comparable in quality to single photon counting hybrid pixel detectors.

Picosecond, tunable, high-brightness hard x-ray inverse Compton source at Duke storage ring

NASA Astrophysics Data System (ADS)

Litvinenko, Vladimir N.; Wu, Ying; Burnham, Bentley; Barnett, Genevieve A.; Madey, John M. J.

1995-09-01

We suggest a state-of-the art x-ray source using a compact electron storage ring with modest energy (less than 1 GeV) and a high power mm-wave as an undulator. A source of this type has x-ray energies and brightness comparable with third generation synchrotron light sources while it can be very compact and fit in a small university or industrial laboratory or hospital. We propose to operate an isochronous mm-wave FEL and a hard x-ray inverse Compton source at the Duke storage ring to test this concept. Resonant FEL conditions for the mm- wave will be provided by the off-axis interaction with an electromagnetic wave. A special optical resonator with holes for the e-beam is proposed for pumping a hard x-ray inverse Compton source with very high brightness. Simulation results of mm-wave FEL operation of the Duke storage ring are discussed. Expected performance of mm-wave FEL and hard x-ray inverse Compton source are presented.

Beam Conditioning for FELs: Consequences and Methods

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wolski, Andrzej; Penn, Gregory; Sessler, Andrew

2003-10-09

The consequences of beam conditioning in four example cases (VISA, a Soft X-Ray FEL, LCLS and a ''Greenfield'' FEL) are examined. It is shown that in emittance limited cases, proper conditioning reduces sensitivity to the transverse emittance, and allows stronger focusing in the undulator. Simulations show higher saturation power, with gain lengths reduced up to a factor of two. The beam dynamics in a general conditioning system are studied, with ''matching conditions'' derived for achieving conditioning without growth in effective emittance. Various conditioners are considered, and expressions derived for the amount of conditioning provided in each case when the matchingmore » conditions are satisfied. We discuss the prospects for conditioners based on laser and plasma systems.« less

A SYNCHRONIZED FIR/VUV LIGHT SOURCE AT JEFFERSON LAB

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stephen Benson, David Douglas, George Neil, Michelle D. Shinn, Gwyn Williams

We describe a dual free-electron laser (FEL) configuration on the UV Demo FEL at Jefferson Lab that allows simultaneous lasing at FIR/THz and UV wavelengths. The FIR/THz source would be an FEL oscillator with a short wiggler providing nearly diffraction-limited pulses with pulse energy exceeding 50 microJoules. The FIR source would use the exhaust beam from a UVFEL. The coherent harmonics in the VUV from the UVFEL are out-coupled through a hole. The FIR source uses a shorter resonator with either hole or edge coupling to provide very high power FIR pulses. Simulations indicate excel-lent spectral brightness in the FIRmore » region with over 100 W/cm-1 output.« less

Experimental characterization of the saturating, near infrared, self-amplified spontaneous emission free electron laser: Analysis of radiation properties and electron beam dynamics

NASA Astrophysics Data System (ADS)

Murokh, Alex

2002-01-01

In this work, the main results of the VISA experiment (Visible to Infrared SASE Amplifier) are presented and analyzed. The purpose of the experiment was to build a state-of-the-art single pass self-amplified spontaneous emission (SASE) free electron laser (FEL) based on a high brightness electron beam, and characterize its operation, including saturation, in the near infrared spectral region. This experiment was hosted by Accelerator Test Facility (ATF) at Brookhaven National Laboratory, which is a users facility that provides high brightness relativistic electron beams generated with the photoinjector. During the experiment, SASE FEL performance was studied in two regimes: a long bunch, lower gain operation; and a short bunch high gain regime. The transition between the two conditions was possible due to a novel bunch compression mechanism, which was discovered in the course of the experiment. This compression allowed the variation of peak current in the electron beam before it was launched into the 4-m VISA undulator. In the long bunch regime, a SASE FEL power gain length of 29 cm was obtained, and the generated radiation spectral and statistical properties were characterized. In the short bunch regime, a power gain length of under 18 cm was achieved at 842 nm, which is at least a factor of two shorter than ever previously achieved in this spectral range. Further, FEL saturation was obtained before the undulator exit. The FEL system's performance was measured along the length of the VISA undulator, and in the final state. Statistical, spectral and angular properties of the short bunch SASE radiation have been measured in the exponential gain regime, and at saturation. One of the most important aspects of the data analysis presented in this thesis was the development and use of start-to-end numerical simulations of the experiment. The dynamics of the ATF electron beam was modeled starting from the photocathode, through acceleration, transport, and inside the VISA undulator. The model allowed simulation of SASE process for different beam conditions, including the effects of the novel bunch compression mechanism on the electron beam 6-D phase space distribution. The numerical simulations displayed an excellent agreement with the experimental data, and became key to understanding complex dynamics of the SASE FEL process at VISA.

Molecular Dynamics Simulation of Amorphous Hydroxypropylmethylcellulose and Its Mixtures With Felodipine and Water.

PubMed

Xiang, Tian-Xiang; Anderson, Bradley D

2017-03-01

Understanding drug-polymer molecular interactions, their miscibility, supersaturation potential, and the effects of water uptake may be invaluable for selecting amorphous polymer dispersions that can maximize the oral bioavailability of poorly water-soluble drugs. Molecular dynamics simulations were performed using a model for hydroxypropylmethylcellulose (HPMC) resembling the substitution patterns found experimentally. HPMC at low and high water contents (0.9%-23.0% wt/wt) and mixtures with a hydrophobic drug, felodipine (FEL), were constructed. T g values and densities after ∼30 ns aging at 298 K were close to published results. Except for hydrogen bonds (HBs) between the 5-O- and a 3-OH group in a neighboring repeat unit, HPMC oxygen atoms have a low HB probability (p < 0.1) perhaps due to shielding by surrounding substituents. Water molecules tend to be isolated at low water content while clusters were prevalent at ≥10.7% water. The Flory-Huggins FEL-HPMC interaction parameter (-0.20 ± 0.07) predicts complete miscibility at all HPMC compositions, in agreement with experiments. However, HBs between the FEL-N-H and HPMC favoring miscibility are disrupted with increasing water. Apparent diffusion coefficients versus water content were generated for water and FEL and a theory for the non-Einsteinian nature of water diffusion is proposed. Copyright © 2017 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Clocking Femtosecond Collisional Dynamics via Resonant X-Ray Spectroscopy

NASA Astrophysics Data System (ADS)

van den Berg, Q. Y.; Fernandez-Tello, E. V.; Burian, T.; Chalupský, J.; Chung, H.-K.; Ciricosta, O.; Dakovski, G. L.; Hájková, V.; Hollebon, P.; Juha, L.; Krzywinski, J.; Lee, R. W.; Minitti, M. P.; Preston, T. R.; de la Varga, A. G.; Vozda, V.; Zastrau, U.; Wark, J. S.; Velarde, P.; Vinko, S. M.

2018-02-01

Electron-ion collisional dynamics is of fundamental importance in determining plasma transport properties, nonequilibrium plasma evolution, and electron damage in diffraction imaging applications using bright x-ray free-electron lasers (FELs). Here we describe the first experimental measurements of ultrafast electron impact collisional ionization dynamics using resonant core-hole spectroscopy in a solid-density magnesium plasma, created and diagnosed with the Linac Coherent Light Source x-ray FEL. By resonantly pumping the 1 s →2 p transition in highly charged ions within an optically thin plasma, we have measured how off-resonance charge states are populated via collisional processes on femtosecond time scales. We present a collisional cross section model that matches our results and demonstrates how the cross sections are enhanced by dense-plasma effects including continuum lowering. Nonlocal thermodynamic equilibrium collisional radiative simulations show excellent agreement with the experimental results and provide new insight on collisional ionization and three-body-recombination processes in the dense-plasma regime.

Clocking Femtosecond Collisional Dynamics via Resonant X-Ray Spectroscopy

DOE PAGES

van den Berg, Q. Y.; Fernandez-Tello, E. V.; Burian, T.; ...

2018-02-01

Electron-ion collisional dynamics is of fundamental importance in determining plasma transport properties, nonequilibrium plasma evolution, and electron damage in diffraction imaging applications using bright x-ray free-electron lasers (FELs). Here in this paper, we describe the first experimental measurements of ultrafast electron impact collisional ionization dynamics using resonant core-hole spectroscopy in a solid-density magnesium plasma, created and diagnosed with the Linac Coherent Light Source x-ray FEL. By resonantly pumping the 1s → 2p transition in highly charged ions within an optically thin plasma, we have measured how off-resonance charge states are populated via collisional processes on femtosecond time scales. We presentmore » a collisional cross section model that matches our results and demonstrates how the cross sections are enhanced by dense-plasma effects including continuum lowering. Nonlocal thermodynamic equilibrium collisional radiative simulations show excellent agreement with the experimental results and provide new insight on collisional ionization and three-body-recombination processes in the dense-plasma regime.« less

A fast analytical undulator model for realistic high-energy FEL simulations

NASA Astrophysics Data System (ADS)

Tatchyn, R.; Cremer, T.

1997-02-01

A number of leading FEL simulation codes used for modeling gain in the ultralong undulators required for SASE saturation in the <100 Å range employ simplified analytical models both for field and error representations. Although it is recognized that both the practical and theoretical validity of such codes could be enhanced by incorporating realistic undulator field calculations, the computational cost of doing this can be prohibitive, especially for point-to-point integration of the equations of motion through each undulator period. In this paper we describe a simple analytical model suitable for modeling realistic permanent magnet (PM), hybrid/PM, and non-PM undulator structures, and discuss selected techniques for minimizing computation time.

Progress of the volume FEL (VFEL) experiments in millimeter range

NASA Astrophysics Data System (ADS)

Baryshevsky, V. G.; Batrakov, K. G.; Gurinovich, A. A.; Ilienko, I. I.; Lobko, A. S.; Molchanov, P. V.; Moroz, V. I.; Sofronov, P. F.; Stolyarsky, V. I.

2003-07-01

Use of non-one-dimensional distributed feedback in Volume Free Electron Laser gives possibility of frequency tuning in wide range. In present work, dependence of lasing process on the angle between resonant diffraction grating grooves and direction of electron beam velocity is discussed.

Oscillator Seeding of a High Gain Harmonic Generation FEL in a Radiator-First Configuration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gandhi, P.; Wurtele, J.; Penn, G.

2012-05-20

A longitudinally coherent X-ray pulse from a high repetition rate free electron laser (FEL) is desired for a wide variety of experimental applications. However, generating such a pulse with a repetition rate greater than 1 MHz is a significant challenge. The desired high repetition rate sources, primarily high harmonic generation with intense lasers in gases or plasmas, do not exist now, and, for the multi-MHz bunch trains that superconducting accelerators can potentially produce, are likely not feasible with current technology. In this paper, we propose to place an oscillator downstream of a radiator. The oscillator generates radiation that is usedmore » as a seed for a high gain harmonic generation (HGHG) FEL which is upstream of the oscillator. For the first few pulses the oscillator builds up power and, until power is built up, the radiator has no HGHG seed. As power in the oscillator saturates, the HGHG is seeded and power is produced. The dynamics and stability of this radiator-first scheme is explored analytically and numerically. A single-pass map is derived using a semi-analytic model for FEL gain and saturation. Iteration of the map is shown to be in good agreement with simulations. A numerical example is presented for a soft X-ray FEL.« less

Spontaneous and amplified radiation at the initial stage of a SASE FEL.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Z.; Kim, K.-J.

At the initial stage of a self-amplified spontaneous emission (SASE) free-electron laser (FEL), spontaneous undulator radiation in certain experimental configurations can dominate the amplified signal over an extended undulator distance. In this paper they study both the spontaneous and the amplified radiation in the framework of the paraxial wave equation and determine the transition from the dominance of spontaneous emission to exponential amplification. They compare theoretical expectations with SASE simulation codes GINGER and GENESIS.

Reversible beam heater for suppression of microbunching instability by transverse gradient undulators

NASA Astrophysics Data System (ADS)

Liu, Tao; Qin, Weilun; Wang, Dong; Huang, Zhirong

2017-08-01

The microbunching instability driven by beam collective effects in a linear accelerator of a free-electron laser (FEL) facility significantly degrades the electron beam quality and FEL performance. A conventional method to suppress this instability is to introduce an additional uncorrelated energy spread by laser-electron interaction, which has been successfully operated in the Linac Coherent Light Source and Fermi@Elettra, etc. Some other ideas are recently proposed to suppress the instability without increasing energy spread, which could benefit the seeded FEL schemes. In this paper, we propose a reversible electron beam heater using two transverse gradient undulators to suppress the microbunching instability. This scheme introduces both an energy spread increase and a transverse-to-longitudinal phase space coupling, which suppress the microbunching instabilities driven by both longitudinal space charge and coherent synchrotron radiation before and within the system. Finally the induced energy spread increase and emittance growth are reversed. Theoretical analysis and numerical simulations are presented to verify the feasibility of the scheme and indicate the capability to improve the seeded FEL radiation performance.

FEL Trajectory Analysis for the VISA Experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nuhn, Heinz-Dieter

1998-10-06

The Visual to Infrared SASE Amplifier (VISA) [1] FEL is designed to achieve saturation at radiation wavelengths between 800 and 600 nm with a 4-m pure permanent magnet undulator. The undulator comprises four 99-cm segments each of which has four FODO focusing cells superposed on the beam by means of permanent magnets in the gap alongside the beam. Each segment will also have two beam position monitors and two sets of x-y dipole correctors. The trajectory walk-off in each segment will be reduced to a value smaller than the rms beam radius by means of magnet sorting, precise fabrication, andmore » post-fabrication shimming and trim magnets. However, this leaves possible inter-segment alignment errors. A trajectory analysis code has been used in combination with the FRED3D [2] FEL code to simulate the effect of the shimming procedure and segment alignment errors on the electron beam trajectory and to determine the sensitivity of the FEL gain process to trajectory errors. The paper describes the technique used to establish tolerances for the segment alignment.« less

Reversible beam heater for suppression of microbunching instability by transverse gradient undulators

DOE PAGES

Liu, Tao; Qin, Weilun; Wang, Dong; ...

2017-08-02

The microbunching instability driven by beam collective effects in a linear accelerator of a free-electron laser (FEL) facility significantly degrades the electron beam quality and FEL performance. A conventional method to suppress this instability is to introduce an additional uncorrelated energy spread by laser-electron interaction, which has been successfully operated in the Linac Coherent Light Source and Fermi@Elettra, etc. Some other ideas are recently proposed to suppress the instability without increasing energy spread, which could benefit the seeded FEL schemes. In this paper, we propose a reversible electron beam heater using two transverse gradient undulators to suppress the microbunching instability.more » This scheme introduces both an energy spread increase and a transverse-to-longitudinal phase space coupling, which suppress the microbunching instabilities driven by both longitudinal space charge and coherent synchrotron radiation before and within the system. Finally the induced energy spread increase and emittance growth are reversed. In conclusion, theoretical analysis and numerical simulations are presented to verify the feasibility of the scheme and indicate the capability to improve the seeded FEL radiation performance.« less

The Effect of Three-Dimensional Simulations on the Understanding of Chemical Structures and Their Properties

ERIC Educational Resources Information Center

Urhahne, Detlef; Nick, Sabine; Schanze, Sascha

2009-01-01

In a series of three experimental studies, the effectiveness of three-dimensional computer simulations to aid the understanding of chemical structures and their properties was investigated. Arguments for the usefulness of three-dimensional simulations were derived from Mayer's generative theory of multimedia learning. Simulations might lead to a…

Molecular characterization and application of lipase from Bacillus sp. PU1 and investigation of structural changes based on pH and temperature using MD simulation.

PubMed

Esakkiraj, Palanichamy; Antonyraj, Christian Bharathi; Meleppat, Balraj; Ankaiah, Dasari; Ayyanna, Repally; Ahamed, Syed Ibrahim Basheer; Arul, Venkatesan

2017-10-01

A gene coding lipase from Bacillus sp. PU1 was cloned and expressed in E. coli BL21(DE3) pLysS. The purified lipase has a molecular weight of 23kDa, is highly alkaline (pH range 8-10) and mesophilic (20-50°C). Three dimensional structure of the lipase was modeled by comparative homology and identified as a typical serine lipase by the presence of conserved Ser77, Asp133, His156. The molecular stability and behavior of the lipase was carried out using MD simulation studies at different pH and temperature was performed in comparison with biochemical analysis. Structural modifications of the lipase under these conditions were trapped by dihedral based FEL analysis and the functional loops (loop-H5/B4 and loop-H6/B5 of lipase) are identified which would cause the catalytic behavior of the lipase by high flexibility. Further characteristic feature of lipase are observed as follows; SDS completely inhibits the lipase activity and enzyme activity is enhanced with non-ionic surfactants. The lipase was highly stable in different organic solvents and also it could tolerate NaCl (0.4-0.8M). This enzyme was found to disrupt the biofilm of tested pathogenic bacterial strains. Copyright © 2017 Elsevier B.V. All rights reserved.

BEAM OPTIMIZATION STUDY FOR AN X-RAY FEL OSCILLATOR AT THE LCLS-II

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qin, Weilun; Huang, S.; Liu, K.X.

2016-06-01

The 4 GeV LCLS-II superconducting linac with high repetition beam rate enables the possibility to drive an X-Ray FEL oscillator at harmonic frequencies *. Compared to the regular LCLS-II machine setup, the oscillator mode requires a much longer bunch length with a relatively lower current. Also a flat longitudinal phase space distribution is critical to maintain the FEL gain since the X-ray cavity has extremely narrow bandwidth. In this paper, we study the longitudinal phase space optimization including shaping the initial beam from the injector and optimizing the bunch compressor and dechirper parameters. We obtain a bunch with a flatmore » energy chirp over 400 fs in the core part with current above 100 A. The optimization was based on LiTrack and Elegant simulations using LCLS-II beam parameters.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carr, Roger

The VISA (Visible to Infrared SASE Amplifier) FEL is designed to obtain high gain at a radiation wavelength of 800nm. The FEL uses the high brightness electron beam of the Accelerator Test Facility (ATF), with energy of 72MeV. VISA uses a novel, 4 m long, strong focusing undulator with a gap of 6mm and a period of 1.8cm. To obtain large gain the beam and undulator axis have to be aligned to better than 50{micro}m. Results from initial measurements on the alignment, gain, and spectrum will be presented and compared to theoretical calculations and simulations.

Simulation studies of a XUV/soft X-ray harmonic-cascade FEL for the proposed LBNL recirculating linac*

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fawley, W.M.; Barletta, W.A.; Corlett, J.N.

Presently there is significant interest at LBNL in designing and building a facility for ultrafast (i.e. femtosecond time scale) x-ray science based upon a superconducting, recirculating RF linac (see Corlett et al. for more details). In addition to producing synchrotron radiation pulses in the 1-15 keV energy range, we are also considering adding one or more free-electron laser (FEL) beamlines using a harmonic cascade approach to produce coherent XUV soft X-ray emission beginning with a strong input seed at {approx}200 nm wavelength obtained from a ''conventional'' laser. Each cascade is composed of a radiator together with a modulator section, separatedmore » by a magnetic chicane. The chicane temporally delays the electron beam pulse in order that a ''virgin'' pulse region (with undegraded energy spread) be brought into synchronism with the radiation pulse, which together then undergo FEL action in the modulator. We present various results obtained with the GINGER simulation code examining final output sensitivity to initial electron beam parameters. We also discuss the effects of spontaneous emission and shot noise upon this particular cascade approach which can limit the final output coherence.« less

Beam conditioning for FELs: Consequences and methods

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wolski, A.; Penn, G.; Sessler, A.

2004-06-29

The consequences of beam conditioning in four example cases (VISA, a Soft X-Ray FEL, LCLS and a ''Greenfield'' FEL) are examined. It is shown that in emittance limited cases, proper conditioning reduces sensitivity to the transverse emittance and, furthermore, allows for stronger focusing in the undulator. Simulations show higher saturation power, with gain lengths reduced by a factor of two or more. The beam dynamics in a general conditioning system are studied, with ''matching conditions'' derived for achieving conditioning without growth in the effective emittance. Various conditioning lattices are considered, and expressions derived for the amount of conditioning provided inmore » each case when the matching conditions are satisfied. These results show that there is no fundamental obstacle to producing beam conditioning, and that the problem can be reduced to one of proper lattice design. Nevertheless, beam conditioning will not be easy to implement in practice.« less

Simulation of Mirror Distortion in Free-Electron LASER Oscillators

DOE Office of Scientific and Technical Information (OSTI.GOV)

H. Freund; S. V. Benson; Michelle D. Shinn

2006-09-01

The JLab FEL is routinely operated with sub-picosecond bunches. The short bunch length is important for high gain of the FEL. Coherent transition radiation has been used for the bunch length measurements for many years. This diagnostic can be used only in the pulsed beam mode. It is our goal to run FEL with CW beam and 74.85 MHz micropulse repetition rate. Hence it is very desirable to have the possibility of doing the bunch length measurements when running CW beam with any micropulse frequency. We use a Fourier transform infrared interferometer, which is essentially a Michelson interferometer, to measuremore » the spectrum of the coherent synchrotron radiation generated in the last dipole of the magnetic bunch compressor upstream of the FEL wiggler. This noninvasive diagnostic provides the bunch length measurements for CW beam operation at any micropulse frequency. We also compare the measurements made with the help of the FTIR interferometer with the data obtained by the Martin-Puplett interferometer. Results of the two diagnostics are usually agree within 15%. Here we present a description of the experimental setup, data evaluation procedure and results of the beam measurements.« less

Mode-Locked Multichromatic X-Rays in a Seeded Free-Electron Laser for Single-Shot X-Ray Spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xiang, Dao; Ding, Yuantao; Raubenheimer, Tor

2012-05-10

We present the promise of generating gigawatt mode-locked multichromatic x rays in a seeded free-electron laser (FEL). We show that, by using a laser to imprint periodic modulation in electron beam phase space, a single-frequency coherent seed can be amplified and further translated to a mode-locked multichromatic output in an FEL. With this configuration the FEL output consists of a train of mode-locked ultrashort pulses which span a wide frequency gap with a series of equally spaced sharp lines. These gigawatt multichromatic x rays may potentially allow one to explore the structure and dynamics of a large number of atomicmore » states simultaneously. The feasibility of generating mode-locked x rays ranging from carbon K edge ({approx}284 eV) to copper L{sub 3} edge ({approx}931 eV) is confirmed with numerical simulation using the realistic parameters of the linac coherent light source (LCLS) and LCLS-II. We anticipate that the mode-locked multichromatic x rays in FELs may open up new opportunities in x-ray spectroscopy (i.e. resonant inelastic x-ray scattering, time-resolved scattering and spectroscopy, etc.).« less

Framework to model neutral particle flux in convex high aspect ratio structures using one-dimensional radiosity

NASA Astrophysics Data System (ADS)

Manstetten, Paul; Filipovic, Lado; Hössinger, Andreas; Weinbub, Josef; Selberherr, Siegfried

2017-02-01

We present a computationally efficient framework to compute the neutral flux in high aspect ratio structures during three-dimensional plasma etching simulations. The framework is based on a one-dimensional radiosity approach and is applicable to simulations of convex rotationally symmetric holes and convex symmetric trenches with a constant cross-section. The framework is intended to replace the full three-dimensional simulation step required to calculate the neutral flux during plasma etching simulations. Especially for high aspect ratio structures, the computational effort, required to perform the full three-dimensional simulation of the neutral flux at the desired spatial resolution, conflicts with practical simulation time constraints. Our results are in agreement with those obtained by three-dimensional Monte Carlo based ray tracing simulations for various aspect ratios and convex geometries. With this framework we present a comprehensive analysis of the influence of the geometrical properties of high aspect ratio structures as well as of the particle sticking probability on the neutral particle flux.

Free-electron laser emission architecture impact on extreme ultraviolet lithography

NASA Astrophysics Data System (ADS)

Hosler, Erik R.; Wood, Obert R.; Barletta, William A.

2017-10-01

Laser-produced plasma (LPP) EUV sources have demonstrated ˜125 W at customer sites, establishing confidence in EUV lithography (EUVL) as a viable manufacturing technology. However, for extension to the 3-nm technology node and beyond, existing scanner/source technology must enable higher-NA imaging systems (requiring increased resist dose and providing half-field exposures) and/or EUV multipatterning (requiring increased wafer throughput proportional to the number of exposure passes). Both development paths will require a substantial increase in EUV source power to maintain the economic viability of the technology, creating an opportunity for free-electron laser (FEL) EUV sources. FEL-based EUV sources offer an economic, high-power/single-source alternative to LPP EUV sources. Should FELs become the preferred next-generation EUV source, the choice of FEL emission architecture will greatly affect its operational stability and overall capability. A near-term industrialized FEL is expected to utilize one of the following three existing emission architectures: (1) self-amplified spontaneous emission, (2) regenerative amplifier, or (3) self-seeding. Model accelerator parameters are put forward to evaluate the impact of emission architecture on FEL output. Then, variations in the parameter space are applied to assess the potential impact to lithography operations, thereby establishing component sensitivity. The operating range of various accelerator components is discussed based on current accelerator performance demonstrated at various scientific user facilities. Finally, comparison of the performance between the model accelerator parameters and the variation in parameter space provides a means to evaluate the potential emission architectures. A scorecard is presented to facilitate this evaluation and provides a framework for future FEL design and enablement for EUVL applications.

Free-electron laser spectroscopy in biology, medicine, and materials science; Proceedings of the Meeting, Los Angeles, CA, Jan. 22, 1993

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schwettman, H.A.

1993-01-01

Various papers on FEL spectroscopy in biology, medicine, and materials science are presented. Individual topics addressed include: Vanderbilt University FEL Center, FIR FEL facility at the University of California/Santa Barbara, FEL research facilities and opportunities at Duke, facilities at the Stanford Picosecond FEL Center, FIR nonlinear response of electrons in semiconductor nanostructures, FIR harmonic generation from semiconductor heterostructures, intrinsic response times of double-barrier resonant tunneling diodes at tetrahertz frequencies, semiconductor spectroscopy and ablation processes with the Vanderbilt FEL. Also discussed are: picosecond nonlinear optics in semiconductor quantum wells with the SCA FEL, excitation spectroscopy of thin-film disordered semiconductors, biophysical applicationmore » of FELs, FEL investigation of energy transfer in condensed phase systems, probing protein photochemistry and dynamics with ultrafast infrared spectroscopy, plasma ablation of hard tissues by FEL, FEL irradiation of the cornea.« less

7 Å Resolution in Protein 2-Dimentional-Crystal X-Ray Diffraction at Linac Coherent Light Source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pedrini, Bill; Tsai, Ching-Ju; Capitani, Guido

2014-06-09

Membrane proteins arranged as two-dimensional (2D) crystals in the lipid en- vironment provide close-to-physiological structural information, which is essential for understanding the molecular mechanisms of protein function. X-ray diffraction from individual 2D crystals did not represent a suitable investigation tool because of radiation damage. The recent availability of ultrashort pulses from X-ray Free Electron Lasers (X-FELs) has now provided a mean to outrun the damage. Here we report on measurements performed at the LCLS X-FEL on bacteriorhodopsin 2D crystals mounted on a solid support and kept at room temperature. By merg- ing data from about a dozen of single crystalmore » diffraction images, we unambiguously identified the diffraction peaks to a resolution of 7 °A, thus improving the observable resolution with respect to that achievable from a single pattern alone. This indicates that a larger dataset will allow for reliable quantification of peak intensities, and in turn a corresponding increase of resolution. The presented results pave the way to further X-FEL studies on 2D crystals, which may include pump-probe experiments at subpicosecond time resolution.« less

FEL system with homogeneous average output

DOEpatents

Douglas, David R.; Legg, Robert; Whitney, R. Roy; Neil, George; Powers, Thomas Joseph

2018-01-16

A method of varying the output of a free electron laser (FEL) on very short time scales to produce a slightly broader, but smooth, time-averaged wavelength spectrum. The method includes injecting into an accelerator a sequence of bunch trains at phase offsets from crest. Accelerating the particles to full energy to result in distinct and independently controlled, by the choice of phase offset, phase-energy correlations or chirps on each bunch train. The earlier trains will be more strongly chirped, the later trains less chirped. For an energy recovered linac (ERL), the beam may be recirculated using a transport system with linear and nonlinear momentum compactions M.sub.56, which are selected to compress all three bunch trains at the FEL with higher order terms managed.

THE FIRST LASING OF 193 NM SASE, 4TH HARMONIC HGHG AND ESASE AT THE NSLS SDL.

DOE Office of Scientific and Technical Information (OSTI.GOV)

WANG, X.J.; SHEN Y.; WATANABE, T.

2006-08-28

The first lasing of three types of single-pass high-gain FELs, SASE at 193 nm, 4th harmonic HGHG at 199 nm and ESASE at the Source Development Lab (SDL) of Brookhaven National Laboratory (BNL) is reported. The saturation of 4th harmonic HGHG and ESASE FELs was observed. We also observed the spectral broadening and instability of the 4th harmonic HGHG.

Radiation damage to macromolecules: kill or cure?

PubMed

Garman, Elspeth F; Weik, Martin

2015-03-01

Radiation damage induced by X-ray beams during macromolecular diffraction experiments remains an issue of concern in structural biology. While advances in our understanding of this phenomenon, driven in part by a series of workshops in this area, undoubtedly have been and are still being made, there are still questions to be answered. Eight papers in this volume give a flavour of ongoing investigations, addressing various issues. These range over: a proposed new metric derived from atomic B-factors for identifying potentially damaged amino acid residues, a study of the relative damage susceptibility of protein and DNA in a DNA/protein complex, a report of an indication of specific radiation damage to a protein determined from data collected using an X-ray free-electron laser (FEL), an account of the challenges in FEL raw diffraction data analysis, an exploration of the possibilities of using radiation damage induced phasing to solve structures using FELs, simulations of radiation damage as a function of FEL temporal pulse profiles, results on the influence of radiation damage during scanning X-ray diffraction measurements and, lastly, consideration of strategies for minimizing radiation damage during SAXS experiments. In this short introduction, these contributions are briefly placed in the context of other current work on radiation damage in the field.

Performance of a Combined System Using an X-Ray FEL Oscillator and a High-Gain FEL Amplifier

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gupta, L.; Lindberg, R.; Kim, K. -J.

The LCLS-II at SLAC will feature a 4 GeV CW superconducting (SC) RF linac [1] that can potentially drive a 5th harmonic X-Ray FEL Oscillator (XFELO) to produce fully coherent, 1 MW photon pulses with a 5 meV bandwidth at 14.4 keV [2]. The XFELO output can serve as the input seed signal for a high-gain FEL amplifier employing fs electron beams from the normal conducting SLAC linac, thereby generating coherent, fs x-ray pulses with TW peak powers using a tapered undulator after saturation [3]. Coherent, intense output at several tens of keV will also be feasible if one considersmore » a harmonic generation scheme. Thus, one can potentially reach the 42 keV photon energy required for the MaRIE project [4] by beginning with an XFELO operating at the 3rd harmonic to produce 14.0 keV photons using a 12 GeV SCRF linac, and then subsequently using the high-gain harmonic generation scheme to generate and amplify the 3th harmonic at 42 keV [5]. We report extensive GINGER simulations that determine an optimized parameter set for the combined system.« less

Harmonic cascade FEL designs for LUX

DOE Office of Scientific and Technical Information (OSTI.GOV)

Penn, G.; Reinsch, M.; Wurtele, J.

LUX is a design concept for an ultrafast X-ray science facility, based on an electron beam accelerated to GeV energies in are circulating linac. Included in the design are short duration (200 fs or shorter FWHM) light sources using multiple stages of higher harmonic generation, seeded by a 200-250 nm laser of similar duration. This laser modulates the energy of a group of electrons within the electron bunch; this section of the electron bunch then produces radiation at a higher harmonic after entering a second, differently tuned undulator. Repeated stages in a cascade yield increasing photon energies up to 1more » keV. Most of the undulators in the cascade operate in the low-gain FEL regime. Harmonic cascades have been designed for each pass of the recirculating linac up to a final electron beam energy of 3.1 GeV. For a given cascade, the photon energy can be selected over a wide range by varying the seed laser frequency and the field strength in the undulators. We present simulation results using the codes GENESIS and GINGER, as well as the results of analytical models which predict FEL performance. We discuss lattice considerations pertinent for harmonic cascade FELs, as well as sensitivity studies and requirements on the electron beam.« less

Simulating Mission Command for Planning and Analysis

DTIC Science & Technology

2015-06-01

mission plan. 14. SUBJECT TERMS Mission Planning, CPM , PERT, Simulation, DES, Simkit, Triangle Distribution, Critical Path 15. NUMBER OF...Battalion Task Force CO Company CPM Critical Path Method DES Discrete Event Simulation FA BAT Field Artillery Battalion FEL Future Event List FIST...management tools that can be utilized to find the critical path in military projects. These are the Critical Path Method ( CPM ) and the Program Evaluation and

Compact beam transport system for free-electron lasers driven by a laser plasma accelerator

DOE PAGES

Liu, Tao; Zhang, Tong; Wang, Dong; ...

2017-02-01

Utilizing laser-driven plasma accelerators (LPAs) as a high-quality electron beam source is a promising approach to significantly downsize the x-ray free-electron laser (XFEL) facility. A multi-GeV LPA beam can be generated in several-centimeter acceleration distance, with a high peak current and a low transverse emittance, which will considerably benefit a compact FEL design. However, the large initial angular divergence and energy spread make it challenging to transport the beam and realize FEL radiation. In this paper, a novel design of beam transport system is proposed to maintain the superior features of the LPA beam and a transverse gradient undulator (TGU)more » is also adopted as an effective energy spread compensator to generate high-brilliance FEL radiation. As a result, theoretical analysis and numerical simulations are presented based on a demonstration experiment with an electron energy of 380 MeV and a radiation wavelength of 30 nm.« less

Microbunching-instability-induced sidebands in a seeded free-electron laser

DOE PAGES

Zhang, Zhen; Lindberg, Ryan; Fawley, William M.; ...

2016-05-02

Measurements of the multishot-averaged, soft x-ray, self-seeding spectrum at the LCLS free-electron laser often have a pedestal-like distribution around the seeded wavelength, which limits the spectral purity and can negatively affect some user applications not employing a post-undulator monochromator. In this paper, we study the origins of such pedestals, focusing on longitudinal phase space modulations produced by the microbunching instability upstream of the free-electron laser (FEL) undulator. Furthermore, we show from theory and numerical simulation that both energy and density modulations can induce sidebands in a high-gain, seeded FEL whose fractional strength typically grows as the square of the undulatormore » length. The results place a tight constraint on the longitudinal phase space uniformity of the electron beam for a seeded FEL, possibly requiring the amplitude of long-wavelength modulations to be much smaller than the typical incoherent energy spread if the output sideband power is to remain only a couple percent or less of the amplified seed power.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nuhn, Heinz-Dieter.

The Visual to Infrared SASE Amplifier (VISA) [1] FEL is designed to achieve saturation at radiation wavelengths between 800 and 600 nm with a 4-m pure permanent magnet undulator. The undulator comprises four 99-cm segments each of which has four FODO focusing cells superposed on the beam by means of permanent magnets in the gap alongside the beam. Each segment will also have two beam position monitors and two sets of x-y dipole correctors. The trajectory walk-off in each segment will be reduced to a value smaller than the rms beam radius by means of magnet sorting, precise fabrication, andmore » post-fabrication shimming and trim magnets. However, this leaves possible inter-segment alignment errors. A trajectory analysis code has been used in combination with the FRED3D [2] FEL code to simulate the effect of the shimming procedure and segment alignment errors on the electron beam trajectory and to determine the sensitivity of the FEL gain process to trajectory errors. The paper describes the technique used to establish tolerances for the segment alignment.« less

Laser-plasma accelerator-based single-cycle attosecond undulator source

NASA Astrophysics Data System (ADS)

Tibai, Z.; Tóth, Gy.; Nagyváradi, A.; Sharma, A.; Mechler, M. I.; Fülöp, J. A.; Almási, G.; Hebling, J.

2018-06-01

Laser-plasma accelerators (LPAs), producing high-quality electron beams, provide an opportunity to reduce the size of free-electron lasers (FELs) to only a few meters. A complete system is proposed here, which is based on FEL technology and consists of an LPA, two undulators, and other magnetic devices. The system is capable to generate carrier-envelope phase stable attosecond pulses with engineered waveform. Pulses with up to 60 nJ energy and 90-400 attosecond duration in the 30-120 nm wavelength range are predicted by numerical simulation. These pulses can be used to investigate ultrafast field-driven electron dynamics in matter.

Beam Conditioning and Harmonic Generation in Free ElectronLasers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Charman, A.E.; Penn, G.; Wolski, A.

2004-07-05

The next generation of large-scale free-electron lasers (FELs) such as Euro-XFEL and LCLS are to be devices which produce coherent X-rays using Self-Amplified Spontaneous Emission (SASE). The performance of these devices is limited by the spread in longitudinal velocities of the beam. In the case where this spread arises primarily from large transverse oscillation amplitudes, beam conditioning can significantly enhance FEL performance. Future X-ray sources may also exploit harmonic generation starting from laser-seeded modulation. Preliminary analysis of such devices is discussed, based on a novel trial-function/variational-principle approach, which shows good agreement with more lengthy numerical simulations.

Computer simulation of plasma and N-body problems

NASA Technical Reports Server (NTRS)

Harries, W. L.; Miller, J. B.

1975-01-01

The following FORTRAN language computer codes are presented: (1) efficient two- and three-dimensional central force potential solvers; (2) a three-dimensional simulator of an isolated galaxy which incorporates the potential solver; (3) a two-dimensional particle-in-cell simulator of the Jeans instability in an infinite self-gravitating compressible gas; and (4) a two-dimensional particle-in-cell simulator of a rotating self-gravitating compressible gaseous system of which rectangular coordinate and superior polar coordinate versions were written.

Initialization and Simulation of Three-Dimensional Aircraft Wake Vortices

NASA Technical Reports Server (NTRS)

Ash, Robert L.; Zheng, Z. C.

1997-01-01

This paper studies the effects of axial velocity profiles on vortex decay, in order to properly initialize and simulate three-dimensional wake vortex flow. Analytical relationships are obtained based on a single vortex model and computational simulations are performed for a rather practical vortex wake, which show that the single vortex analytical relations can still be applicable at certain streamwise sections of three-dimensional wake vortices.

A helical optical for circular polarized UV-FEL project at the UVSOR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hama, Hiroyuki

1995-12-31

Most of existing storage ring free electron lasers (SRFEL) are restricted those performances by degradation of mirrors in optical cavities. In general, the SRFEL gain at the short wavelength region with high energy electrons is quite low, and the high reflectivity mirrors such as dielectric multilayer mirrors are therefore required. The mirror degradation is considered as a result of irradiation of higher harmonic photons that are simultaneously emitted from planar optical klystron (OK) type undulators, which are commonly used in SRFEL. This problem is getting severer as the lasing wavelength becomes shorter. The UVSOR-FEL had been originally scheduled to bemore » shutdown by 1996 because another undulator project for spectroscopic studies with circular polarized photon would take the FEL`s place. According to suggestion of the insertion device group of the SPring-8, we have designed a helical undulator that is able to vary degree and direction of the polarization easily. In addition, the undulator can be converted into a helical OK by replacing magnets at the center part of undulator in order to coexist with further FEL experiments. Using a calculated magnetic field for magnet configurations of the OK mode, the radiation spectrum at wide wavelength range was simulated by a Fourier transform of Lienard-Wiechert potentials. As a matter of course, some higher harmonics are radiated on the off-axis angle. However it was found out that the higher harmonics is almost negligible as far as inside a solid angle of the Gaussian laser mode. Moreover the gain at the UV region of 250 nm is expected to be much higher than our present FEL because of high brilliant fundamental radiation. The calculated spatial distribution of higher harmonics and the estimated instantaneous gain is presented. Advantages of the helical OK for SRFEL will be discussed in view of our experience, and a possibility of application two-color experiment with SR will be also mentioned.« less

Experimental Investigation of Superradiance in a Tapered Free-Electron Laser Amplifier

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hidaka, Y.; She, Y.; Murphy, J.B.

2011-03-28

We report experimental studies of the effect of undulator tapering on superradiance in a single-pass high-gain free-electron laser (FEL) amplifier. The experiments were performed at the Source Development Laboratory (SDL) of National Synchrotron Light Source (NSLS). Efficiency was nearly tripled with tapering. Both the temporal and spectral properties of the superradiant FEL along the uniform and tapered undulator were experimentally characterized using frequency-resolved optical gating (FROG) images. Numerical studies predicted pulse broadening and spectral cleaning by undulator tapering Pulse broadening was experimentally verified. However, spectral cleanliness degraded with tapering. We have performed first experiments with a tapered undulator and amore » short seed laser pulse. Pulse broadening with tapering expected from simulations was experimentally confirmed. However, the experimentally obtained spectra degraded with tapering, whereas the simulations predicted improvement. A further numerical study is under way to resolve this issue.« less

Short-wavelength free-electron laser sources and science: a review.

PubMed

Seddon, E A; Clarke, J A; Dunning, D J; Masciovecchio, C; Milne, C J; Parmigiani, F; Rugg, D; Spence, J C H; Thompson, N R; Ueda, K; Vinko, S M; Wark, J S; Wurth, W

2017-11-01

This review is focused on free-electron lasers (FELs) in the hard to soft x-ray regime. The aim is to provide newcomers to the area with insights into: the basic physics of FELs, the qualities of the radiation they produce, the challenges of transmitting that radiation to end users and the diversity of current scientific applications. Initial consideration is given to FEL theory in order to provide the foundation for discussion of FEL output properties and the technical challenges of short-wavelength FELs. This is followed by an overview of existing x-ray FEL facilities, future facilities and FEL frontiers. To provide a context for information in the above sections, a detailed comparison of the photon pulse characteristics of FEL sources with those of other sources of high brightness x-rays is made. A brief summary of FEL beamline design and photon diagnostics then precedes an overview of FEL scientific applications. Recent highlights are covered in sections on structural biology, atomic and molecular physics, photochemistry, non-linear spectroscopy, shock physics, solid density plasmas. A short industrial perspective is also included to emphasise potential in this area.

[Bone drilling simulation by three-dimensional imaging].

PubMed

Suto, Y; Furuhata, K; Kojima, T; Kurokawa, T; Kobayashi, M

1989-06-01

The three-dimensional display technique has a wide range of medical applications. Pre-operative planning is one typical application: in orthopedic surgery, three-dimensional image processing has been used very successfully. We have employed this technique in pre-operative planning for orthopedic surgery, and have developed a simulation system for bone-drilling. Positive results were obtained by pre-operative rehearsal; when a region of interest is indicated by means of a mouse on the three-dimensional image displayed on the CRT, the corresponding region appears on the slice image which is displayed simultaneously. Consequently, the status of the bone-drilling is constantly monitored. In developing this system, we have placed emphasis on the quality of the reconstructed three-dimensional images, on fast processing, and on the easy operation of the surgical planning simulation.

X -band rf driven free electron laser driver with optics linearization

DOE PAGES

Sun, Yipeng; Emma, Paul; Raubenheimer, Tor; ...

2014-11-13

In this paper, a compact hard X-ray free electron lasers (FEL) design is proposed with all X-band rf acceleration and two stage bunch compression. It eliminates the need of a harmonic rf linearization section by employing optics linearization in its first stage bunch compression. Quadrupoles and sextupoles are employed in a bunch compressor one (BC1) design, in such a way that second order longitudinal dispersion of BC1 cancels the second order energy correlation in the electron beam. Start-to-end 6-D simulations are performed with all the collective effects included. Emittance growth in the horizontal plane due to coherent synchrotron radiation ismore » investigated and minimized, to be on a similar level with the successfully operating Linac coherent light source (LCLS). At a FEL radiation wavelength of 0.15 nm, a saturation length of 40 meters can be achieved by employing an undulator with a period of 1.5 cm. Without tapering, a FEL radiation power above 10 GW is achieved with a photon pulse length of 50 fs, which is LCLS-like performance. The overall length of the accelerator plus undulator is around 250 meters which is much shorter than the LCLS length of 1230 meters. That makes it possible to build hard X-ray FEL in a laboratory with limited size.« less

The complete conformational free energy landscape of β-xylose reveals a two-fold catalytic itinerary for β-xylanases.

PubMed

Iglesias-Fernández, Javier; Raich, Lluís; Ardèvol, Albert; Rovira, Carme

2015-02-01

Unraveling the conformational catalytic itinerary of glycoside hydrolases (GHs) is a growing topic of interest in glycobiology, with major impact in the design of GH inhibitors. β-xylanases are responsible for the hydrolysis of glycosidic bonds in β-xylans, a group of hemicelluloses of high biotechnological interest that are found in plant cell walls. The precise conformations followed by the substrate during catalysis in β-xylanases have not been unambiguously resolved, with three different pathways being proposed from structural analyses. In this work, we compute the conformational free energy landscape (FEL) of β-xylose to predict the most likely catalytic itineraries followed by β-xylanases. The calculations are performed by means of ab initio metadynamics, using the Cremer-Pople puckering coordinates as collective variables. The computed FEL supports only two of the previously proposed itineraries, 2 S O → [ 2,5 B] ǂ → 5 S 1 and 1 S 3 → [ 4 H 3 ] ǂ → 4 C 1 , which clearly appear in low energy regions of the FEL. Consistently, 2 S O and 1 S 3 are conformations preactivated for catalysis in terms of free energy/anomeric charge and bond distances. The results however exclude the O E → [ O S 2 ] ǂ → B 2,5 itinerary that has been recently proposed for a family 11 xylanase. Classical and ab initio QM/MM molecular dynamics simulations reveal that, in this case, the observed O E conformation has been enforced by enzyme mutation. These results add a word of caution on using modified enzymes to inform on catalytic conformational itineraries of glycoside hydrolases.

Protein dynamics and motions in relation to their functions: several case studies and the underlying mechanisms

PubMed Central

Yang, Li-Quan; Sang, Peng; Tao, Yan; Fu, Yun-Xin; Zhang, Ke-Qin; Xie, Yue-Hui; Liu, Shu-Qun

2013-01-01

Proteins are dynamic entities in cellular solution with functions governed essentially by their dynamic personalities. We review several dynamics studies on serine protease proteinase K and HIV-1 gp120 envelope glycoprotein to demonstrate the importance of investigating the dynamic behaviors and molecular motions for a complete understanding of their structure–function relationships. Using computer simulations and essential dynamic (ED) analysis approaches, the dynamics data obtained revealed that: (i) proteinase K has highly flexible substrate-binding site, thus supporting the induced-fit or conformational selection mechanism of substrate binding; (ii) Ca2+ removal from proteinase K increases the global conformational flexibility, decreases the local flexibility of substrate-binding region, and does not influence the thermal motion of catalytic triad, thus explaining the experimentally determined decreased thermal stability, reduced substrate affinity, and almost unchanged catalytic activity upon Ca2+ removal; (iii) substrate binding affects the large concerted motions of proteinase K, and the resulting dynamic pocket can be connected to substrate binding, orientation, and product release; (iv) amino acid mutations 375 S/W and 423 I/P of HIV-1 gp120 have distinct effects on molecular motions of gp120, facilitating 375 S/W mutant to assume the CD4-bound conformation, while 423 I/P mutant to prefer for CD4-unliganded state. The mechanisms underlying protein dynamics and protein–ligand binding, including the concept of the free energy landscape (FEL) of the protein–solvent system, how the ruggedness and variability of FEL determine protein's dynamics, and how the three ligand-binding models, the lock-and-key, induced-fit, and conformational selection are rationalized based on the FEL theory are discussed in depth. PMID:23527883

The complete conformational free energy landscape of β-xylose reveals a two-fold catalytic itinerary for β-xylanases† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c4sc02240h Click here for additional data file.

PubMed Central

Iglesias-Fernández, Javier; Raich, Lluís; Ardèvol, Albert

2015-01-01

Unraveling the conformational catalytic itinerary of glycoside hydrolases (GHs) is a growing topic of interest in glycobiology, with major impact in the design of GH inhibitors. β-xylanases are responsible for the hydrolysis of glycosidic bonds in β-xylans, a group of hemicelluloses of high biotechnological interest that are found in plant cell walls. The precise conformations followed by the substrate during catalysis in β-xylanases have not been unambiguously resolved, with three different pathways being proposed from structural analyses. In this work, we compute the conformational free energy landscape (FEL) of β-xylose to predict the most likely catalytic itineraries followed by β-xylanases. The calculations are performed by means of ab initio metadynamics, using the Cremer–Pople puckering coordinates as collective variables. The computed FEL supports only two of the previously proposed itineraries, 2SO → [2,5B]ǂ → 5S1 and 1S3 → [4H3]ǂ → 4C1, which clearly appear in low energy regions of the FEL. Consistently, 2SO and 1S3 are conformations preactivated for catalysis in terms of free energy/anomeric charge and bond distances. The results however exclude the OE → [OS2]ǂ → B2,5 itinerary that has been recently proposed for a family 11 xylanase. Classical and ab initio QM/MM molecular dynamics simulations reveal that, in this case, the observed OE conformation has been enforced by enzyme mutation. These results add a word of caution on using modified enzymes to inform on catalytic conformational itineraries of glycoside hydrolases. PMID:29560204

Protein dynamics and motions in relation to their functions: several case studies and the underlying mechanisms.

PubMed

Yang, Li-Quan; Sang, Peng; Tao, Yan; Fu, Yun-Xin; Zhang, Ke-Qin; Xie, Yue-Hui; Liu, Shu-Qun

2014-01-01

Proteins are dynamic entities in cellular solution with functions governed essentially by their dynamic personalities. We review several dynamics studies on serine protease proteinase K and HIV-1 gp120 envelope glycoprotein to demonstrate the importance of investigating the dynamic behaviors and molecular motions for a complete understanding of their structure-function relationships. Using computer simulations and essential dynamic (ED) analysis approaches, the dynamics data obtained revealed that: (i) proteinase K has highly flexible substrate-binding site, thus supporting the induced-fit or conformational selection mechanism of substrate binding; (ii) Ca(2+) removal from proteinase K increases the global conformational flexibility, decreases the local flexibility of substrate-binding region, and does not influence the thermal motion of catalytic triad, thus explaining the experimentally determined decreased thermal stability, reduced substrate affinity, and almost unchanged catalytic activity upon Ca(2+) removal; (iii) substrate binding affects the large concerted motions of proteinase K, and the resulting dynamic pocket can be connected to substrate binding, orientation, and product release; (iv) amino acid mutations 375 S/W and 423 I/P of HIV-1 gp120 have distinct effects on molecular motions of gp120, facilitating 375 S/W mutant to assume the CD4-bound conformation, while 423 I/P mutant to prefer for CD4-unliganded state. The mechanisms underlying protein dynamics and protein-ligand binding, including the concept of the free energy landscape (FEL) of the protein-solvent system, how the ruggedness and variability of FEL determine protein's dynamics, and how the three ligand-binding models, the lock-and-key, induced-fit, and conformational selection are rationalized based on the FEL theory are discussed in depth.

Vacuum space charge effects in sub-picosecond soft X-ray photoemission on a molecular adsorbate layer

DOE PAGES

Dell'Angela, M.; Anniyev, T.; Beye, M.; ...

2015-03-01

Vacuum space charge-induced kinetic energy shifts of O 1s and Ru 3d core levels in femtosecond soft X-ray photoemission spectra (PES) have been studied at a free electron laser (FEL) for an oxygen layer on Ru(0001). We fully reproduced the measurements by simulating the in-vacuum expansion of the photoelectrons and demonstrate the space charge contribution of the high-order harmonics in the FEL beam. Employing the same analysis for 400 nm pump-X-ray probe PES, we can disentangle the delay dependent Ru 3d energy shifts into effects induced by space charge and by lattice heating from the femtosecond pump pulse.

Vacuum space charge effects in sub-picosecond soft X-ray photoemission on a molecular adsorbate layer.

PubMed

Dell'Angela, M; Anniyev, T; Beye, M; Coffee, R; Föhlisch, A; Gladh, J; Kaya, S; Katayama, T; Krupin, O; Nilsson, A; Nordlund, D; Schlotter, W F; Sellberg, J A; Sorgenfrei, F; Turner, J J; Öström, H; Ogasawara, H; Wolf, M; Wurth, W

2015-03-01

Vacuum space charge induced kinetic energy shifts of O 1s and Ru 3d core levels in femtosecond soft X-ray photoemission spectra (PES) have been studied at a free electron laser (FEL) for an oxygen layer on Ru(0001). We fully reproduced the measurements by simulating the in-vacuum expansion of the photoelectrons and demonstrate the space charge contribution of the high-order harmonics in the FEL beam. Employing the same analysis for 400 nm pump-X-ray probe PES, we can disentangle the delay dependent Ru 3d energy shifts into effects induced by space charge and by lattice heating from the femtosecond pump pulse.

Higher-order harmonics coupling in different free-electron laser codes

NASA Astrophysics Data System (ADS)

Giannessi, L.; Freund, H. P.; Musumeci, P.; Reiche, S.

2008-08-01

The capability for simulation of the dynamics of a free-electron laser including the higher-order harmonics in linear undulators exists in several existing codes as MEDUSA [H.P. Freund, S.G. Biedron, and S.V. Milton, IEEE J. Quantum Electron. 27 (2000) 243; H.P. Freund, Phys. Rev. ST-AB 8 (2005) 110701] and PERSEO [L. Giannessi, Overview of Perseo, a system for simulating FEL dynamics in Mathcad, < http://www.jacow.org>, in: Proceedings of FEL 2006 Conference, BESSY, Berlin, Germany, 2006, p. 91], and has been recently implemented in GENESIS 1.3 [See < http://www.perseo.enea.it>]. MEDUSA and GENESIS also include the dynamics of even harmonics induced by the coupling through the betatron motion. In addition MEDUSA, which is based on a non-wiggler averaged model, is capable of simulating the generation of even harmonics in the transversally cold beam regime, i.e. when the even harmonic coupling arises from non-linear effects associated with longitudinal particle dynamics and not to a finite beam emittance. In this paper a comparison between the predictions of the codes in different conditions is given.

Large-scale three-dimensional phase-field simulations for phase coarsening at ultrahigh volume fraction on high-performance architectures

NASA Astrophysics Data System (ADS)

Yan, Hui; Wang, K. G.; Jones, Jim E.

2016-06-01

A parallel algorithm for large-scale three-dimensional phase-field simulations of phase coarsening is developed and implemented on high-performance architectures. From the large-scale simulations, a new kinetics in phase coarsening in the region of ultrahigh volume fraction is found. The parallel implementation is capable of harnessing the greater computer power available from high-performance architectures. The parallelized code enables increase in three-dimensional simulation system size up to a 5123 grid cube. Through the parallelized code, practical runtime can be achieved for three-dimensional large-scale simulations, and the statistical significance of the results from these high resolution parallel simulations are greatly improved over those obtainable from serial simulations. A detailed performance analysis on speed-up and scalability is presented, showing good scalability which improves with increasing problem size. In addition, a model for prediction of runtime is developed, which shows a good agreement with actual run time from numerical tests.

Three-dimensional Virtual Simulation of Oil Spill of Yangtze River in Chongqing Area Based on Emergency Decision

NASA Astrophysics Data System (ADS)

Chen, Shuzhe; Huang, Liwen

the river of Yangtze River in Chongqing area is continuous curved. Hydrology and channel situation is complex, and the transportation is busy. With the increasing of shipments of hazardous chemicals year by year, oil spill accident risk is rising. So establishment of three-dimensional virtual simulation of oil spill and its application in decision-making has become an urgent task. This paper detailed the process of three-dimensional virtual simulation of oil spill and established a system of three-dimensional virtual Simulation of oil spill of Yangtze River in Chongqing area by establishing an oil spill model of the Chongqing area based on oil particles model, and the system has been used in emergency decision to provide assistance for the oil spill response.

Generation of coherent two-color pulses at two adjacent harmonics in a seeded free-electron laser

NASA Astrophysics Data System (ADS)

Zhao, Zhouyu; Li, Heting; Jia, Qika

2018-02-01

The growing requirements of pump-probe techniques and nonlinear optics experiments greatly promote the studies of two-color free-electron lasers (FELs). We propose a new method to generate coherent two-color pulses in a high-gain harmonic generation (HGHG) FEL. In this scheme, an initial tilted electron beam is sent though the modulator and dispersive section of an HGHG FEL to generate the bunching at harmonics of the seed laser. Then a transverse gradient undulator (TGU) is adopted as the radiator and in such radiator, only two separated fractions of the tilted beam will resonate at two adjacent harmonics of the seed laser and are enabled to emit the coherent two-color pulses simultaneously. The time separation between the two pulses are on the order of hundreds of femtoseconds, and can be precisely controlled by varying the tilted amplitude of the electron beam and/or the transverse gradient of the TGU radiator. Numerical simulations confirm the validity and feasibility of this scheme in the extreme ultraviolet waveband.

Output characteristics of SASE-driven short wavelength FEL`s

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fawley, W.M.

This paper investigates various properties of the ``microspikes`` associated with self-amplified spontaneous emission (SASE) in a short wavelength free-electron laser (FEL). Using results from the 2-D numerical simulation code GINGER, we confirm theoretical predictions such as the convective group velocity in the exponential gain regime. In the saturated gain regime beyond the initial saturation, we find that the average radiation power continues to grow with an approximately linearly dependence upon undulator length. Moreover, the spectrum significantly broadens and shifts in wavelength to the redward direction, with{ital P(w)} approaching a constant, asymptotic value. This is in marked contrast to the exponentialmore » gain regime where the spectrum steadily narrows, {ital P(w)} grows, and the central wavelength remains constant with {ital z}. Via use of a spectrogram diagnostic {ital S(w,t)}, it appears that the radiation pattern in the saturated gain regime is composed of an ensemble of distinct ``sinews`` whose widths AA remain approximately constant but whose central wavelengths can ``chirp`` by varying a small extent with {ital t}.« less

A concept for Z-dependent microbunching measurements with coherent X-ray transition radiation in a sase FEL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lumpkin, A.H.; Fawley, W.M.; Rule, D.W.

We present an adaptation of the measurements performed in the visible-to-VUV regime of the z-dependent microbunching in a self-amplified spontaneous emission (SASE) free-electron laser (FEL). In these experiments a thin metal foil was used to block the more intense SASE radiation and to generate coherent optical transition radiation (COTR) as one source in a two-foil interferometer. However, for the proposed x-ray SASE FELs, the intense SASE emission is either too strongly transmitted at 1.5 Angstrom or the needed foil thickness for blocking scatters the electron beam too much. Since x-ray transition radiation (XTR) is emitted in an annulus with openingmore » angle 1/g = 36 mrad for 14.09-GeV electrons, we propose using a thin foil or foil stack to generate the XTR and coherent XTR (CXTR) and an annular crystal to wavelength sort the radiation. The combined selectivity in angle and wavelength will favor the CXTR over SASE by about eight orders of magnitude. Time-dependent GINGER simulations support the z-dependent gain evaluation plan.« less

Separation of Dynamics in the Free Energy Landscape

NASA Astrophysics Data System (ADS)

Ekimoto, Toru; Odagaki, Takashi; Yoshimori, Akira

2008-02-01

The dynamics of a representative point in a model free energy landscape (FEL) is analyzed by the Langevin equation with the FEL as the driving potential. From the detailed analysis of the generalized susceptibility, fast, slow and Johari-Goldstein (JG) processes are shown to be well described by the FEL. Namely, the fast process is determined by the stochastic motion confined in a basin of the FEL and the relaxation time is related to the curvature of the FEL at the bottom of the basin. The jump motion among basins gives rise to the slow relaxation whose relaxation time is determined by the distribution of the barriers in the FEL and the JG process is produced by weak modulation of the FEL.

Duke storage rink UV/VUV FEL: Status and prospects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Litvinenko, V.N.; Burnham, B.; Madey, J.M.J.

1995-12-31

The 1 GeV Duke storage ring was successfully commissioned with parameters exceeding initial specification. The OK-4 FEL has arrived at the Duke FEL laboratory from the Novosibirsk Institute of Nuclear Physics. The OK-4 installation and commissioning is in progress. In this paper we describe the up-to-date status of the Duke storage ring and the OK-4 FEL. The projected performance of the OK-4 UV/VUV FEL is presented based on the electron beam parameters achieved. Initial plans to operate the OK-4 UV/VUV FEL at the Duke 1 GeV storage ring are outlined. Future plans and prospects of both the OK-4 FEL andmore » the Duke storage ring are discussed.« less

[The three-dimensional simulation of arytenoid cartilage movement].

PubMed

Zhang, Jun; Wang, Xuefeng

2011-08-01

Exploring the characteristics of arytenoid cartilage movement. Using Pro/ENGINEER (Pro/E) software, the cricoid cartilage, arytenoid cartilage and vocal cords were simulated to the three-dimensional reconstruction, by analyzing the trajectory of arytenoid cartilage in the joint surface from the cricoid cartilage and arytenoid cartilage composition. The 3D animation simulation showed the normal movement patterns of the vocal cords and the characteristics of vocal cords movement in occasion of arytenoid cartilage dislocation vividly. The three-dimensional model has clinical significance for arytenoid cartilage movement disorders.

Concentration data and dimensionality in groundwater models: evaluation using inverse modelling

USGS Publications Warehouse

Barlebo, H.C.; Hill, M.C.; Rosbjerg, D.; Jensen, K.H.

1998-01-01

A three-dimensional inverse groundwater flow and transport model that fits hydraulic-head and concentration data simultaneously using nonlinear regression is presented and applied to a layered sand and silt groundwater system beneath the Grindsted Landfill in Denmark. The aquifer is composed of rather homogeneous hydrogeologic layers. Two issues common to groundwater flow and transport modelling are investigated: 1) The accuracy of simulated concentrations in the case of calibration with head data alone; and 2) The advantages and disadvantages of using a two-dimensional cross-sectional model instead of a three-dimensional model to simulate contaminant transport when the source is at the land surface. Results show that using only hydraulic heads in the nonlinear regression produces a simulated plume that is profoundly different from what is obtained in a calibration using both hydraulic-head and concentration data. The present study provides a well-documented example of the differences that can occur. Representing the system as a two-dimensional cross-section obviously omits some of the system dynamics. It was, however, possible to obtain a simulated plume cross-section that matched the actual plume cross-section well. The two-dimensional model execution times were about a seventh of those for the three-dimensional model, but some difficulties were encountered in representing the spatially variable source concentrations and less precise simulated concentrations were calculated by the two-dimensional model compared to the three-dimensional model. Summed up, the present study indicates that three dimensional modelling using both hydraulic heads and concentrations in the calibration should be preferred in the considered type of transport studies.

Generating Neuron Geometries for Detailed Three-Dimensional Simulations Using AnaMorph.

PubMed

Mörschel, Konstantin; Breit, Markus; Queisser, Gillian

2017-07-01

Generating realistic and complex computational domains for numerical simulations is often a challenging task. In neuroscientific research, more and more one-dimensional morphology data is becoming publicly available through databases. This data, however, only contains point and diameter information not suitable for detailed three-dimensional simulations. In this paper, we present a novel framework, AnaMorph, that automatically generates water-tight surface meshes from one-dimensional point-diameter files. These surface triangulations can be used to simulate the electrical and biochemical behavior of the underlying cell. In addition to morphology generation, AnaMorph also performs quality control of the semi-automatically reconstructed cells coming from anatomical reconstructions. This toolset allows an extension from the classical dimension-reduced modeling and simulation of cellular processes to a full three-dimensional and morphology-including method, leading to novel structure-function interplay studies in the medical field. The developed numerical methods can further be employed in other areas where complex geometries are an essential component of numerical simulations.

Novel Out-Coupling Techniques for Terahertz Free Electron Lasers

DTIC Science & Technology

2012-06-01

4  1.   FEL “ Pendulum ” Equation and Electron Dynamics .......................4  2.   FEL...4 B. FEL THEORY 1. FEL “ Pendulum ” Equation and Electron Dynamics The dynamics of electron motion as it passes through the undulator are governed...I.5, then the FEL “ pendulum equation” is derived , (I.7) where is the dimensionless laser field amplitude[1]. From this, it is shown that changes

Short-wavelength free-electron laser sources and science: a review

NASA Astrophysics Data System (ADS)

Seddon, E. A.; Clarke, J. A.; Dunning, D. J.; Masciovecchio, C.; Milne, C. J.; Parmigiani, F.; Rugg, D.; Spence, J. C. H.; Thompson, N. R.; Ueda, K.; Vinko, S. M.; Wark, J. S.; Wurth, W.

2017-11-01

This review is focused on free-electron lasers (FELs) in the hard to soft x-ray regime. The aim is to provide newcomers to the area with insights into: the basic physics of FELs, the qualities of the radiation they produce, the challenges of transmitting that radiation to end users and the diversity of current scientific applications. Initial consideration is given to FEL theory in order to provide the foundation for discussion of FEL output properties and the technical challenges of short-wavelength FELs. This is followed by an overview of existing x-ray FEL facilities, future facilities and FEL frontiers. To provide a context for information in the above sections, a detailed comparison of the photon pulse characteristics of FEL sources with those of other sources of high brightness x-rays is made. A brief summary of FEL beamline design and photon diagnostics then precedes an overview of FEL scientific applications. Recent highlights are covered in sections on structural biology, atomic and molecular physics, photochemistry, non-linear spectroscopy, shock physics, solid density plasmas. A short industrial perspective is also included to emphasise potential in this area. Dedicated to John M J Madey (1943-2016) and Rodolfo Bonifacio (1940-2016) whose perception, drive and perseverance paved the way for the realisation and development of short-wavelength free-electron lasers.

Pulse Duration of Seeded Free-Electron Lasers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Finetti, Paola; Hoppner, Hauke; Allaria, Enrico

The pulse duration, and, more generally, the temporal intensity profile of free-electron laser (FEL) pulses, is of utmost importance for exploring the new perspectives offered by FELs; it is a nontrivial experimental parameter that needs to be characterized. We measured the pulse shape of an extreme ultraviolet externally seeded FEL operating in high-gain harmonic generation mode. Two different methods based on the cross-correlation of the FEL pulses with an external optical laser were used. The two methods, one capable of single-shot performance, may both be implemented as online diagnostics in FEL facilities. The measurements were carried out at the seededmore » FEL facility FERMI. The FEL temporal pulse characteristics were measured and studied in a range of FEL wavelengths and machine settings, and they were compared to the predictions of a theoretical model. Finally, the measurements allowed a direct observation of the pulse lengthening and splitting at saturation, in agreement with the proposed theory.« less

Pulse Duration of Seeded Free-Electron Lasers

DOE PAGES

Finetti, Paola; Hoppner, Hauke; Allaria, Enrico; ...

2017-06-16

The pulse duration, and, more generally, the temporal intensity profile of free-electron laser (FEL) pulses, is of utmost importance for exploring the new perspectives offered by FELs; it is a nontrivial experimental parameter that needs to be characterized. We measured the pulse shape of an extreme ultraviolet externally seeded FEL operating in high-gain harmonic generation mode. Two different methods based on the cross-correlation of the FEL pulses with an external optical laser were used. The two methods, one capable of single-shot performance, may both be implemented as online diagnostics in FEL facilities. The measurements were carried out at the seededmore » FEL facility FERMI. The FEL temporal pulse characteristics were measured and studied in a range of FEL wavelengths and machine settings, and they were compared to the predictions of a theoretical model. Finally, the measurements allowed a direct observation of the pulse lengthening and splitting at saturation, in agreement with the proposed theory.« less

Exploring the folding free energy landscape of a β-hairpin miniprotein, chignolin, using multiscale free energy landscape calculation method.

PubMed

Harada, Ryuhei; Kitao, Akio

2011-07-14

The folding process for a β-hairpin miniprotein, chignolin, was investigated by free energy landscape (FEL) calculations using the recently proposed multiscale free energy landscape calculation method (MSFEL). First, coarse-grained molecular dynamics simulations searched a broad conformational space, then multiple independent, all-atom molecular dynamics simulations with explicit solvent determined the detailed local FEL using massively distributed computing. The combination of the two models enabled efficient calculation of the free energy landscapes. The MSFEL analysis showed that chignolin has an intermediate state as well as a misfolded state. The folding process is initiated by the formation of a β-hairpin turn, followed by the formation of contacts in the hydrophobic core between Tyr2 and Trp9. Furthermore, mutation of Tyr2 shifts the population to the misfolded conformation. The results indicate that the hydrophobic core plays an important role in stabilizing the native state of chignolin. © 2011 American Chemical Society

Multi-Dimensional, Inviscid Flux Reconstruction for Simulation of Hypersonic Heating on Tetrahedral Grids

NASA Technical Reports Server (NTRS)

Gnoffo, Peter A.

2009-01-01

The quality of simulated hypersonic stagnation region heating on tetrahedral meshes is investigated by using a three-dimensional, upwind reconstruction algorithm for the inviscid flux vector. Two test problems are investigated: hypersonic flow over a three-dimensional cylinder with special attention to the uniformity of the solution in the spanwise direction and hypersonic flow over a three-dimensional sphere. The tetrahedral cells used in the simulation are derived from a structured grid where cell faces are bisected across the diagonal resulting in a consistent pattern of diagonals running in a biased direction across the otherwise symmetric domain. This grid is known to accentuate problems in both shock capturing and stagnation region heating encountered with conventional, quasi-one-dimensional inviscid flux reconstruction algorithms. Therefore the test problem provides a sensitive test for algorithmic effects on heating. This investigation is believed to be unique in its focus on three-dimensional, rotated upwind schemes for the simulation of hypersonic heating on tetrahedral grids. This study attempts to fill the void left by the inability of conventional (quasi-one-dimensional) approaches to accurately simulate heating in a tetrahedral grid system. Results show significant improvement in spanwise uniformity of heating with some penalty of ringing at the captured shock. Issues with accuracy near the peak shear location are identified and require further study.

Cat, dog and house dust mite allergen levels on children's soft toys.

PubMed

Wu, Francis Fu-Sheng; Wu, Mei-Wen; Ting, Ming-Hui; Crane, Julian; Siebers, Rob

2014-02-01

Children's soft toys are known to harbour house dust mite (HDM) allergens, but little is known whether they harbour cat or dog allergens. The objective of the study was to measure cat (Fel d 1), dog (Can f 1) and HDM allergens on children's soft toys. Dust was collected from 40 children's soft toys and their mattresses. Data were collected on pet ownership. Dust samples were analysed for Fel d 1, Can f 1, Der p 1 and Der f 1 by enzyme-linked immunosorbent assay (ELISA) and results are expressed as median levels with inter-quartile ranges. Thirty-five (87.5%) soft toys had detectable Fel d 1 levels (median: 0.73 µg/g; inter-quartile range: 0.26-2.56 µg/g) while 34 (85%) had detectable Can f 1 levels (1.20 µg/g; 0.53-2.68). Correspondingly, 32 (80%) mattresses had detectable Fel d 1 levels (0.18 µg/g, 0.07-1.01) while 34 (85%) had detectable Can f 1 levels (0.50 µg/g; 0.33-1.06). All mattresses and soft toys had detectable HDM allergen (Der p 1 + Der f 1) levels with soft toys containing about three times higher levels than mattresses. In homes with cats (n = 10) Fel d 1 levels were higher on soft toys than homes without cats (2.49 versus 0.48 µg/g; p = 0.0009). In homes with dogs (n = 25) Can f 1 levels were generally higher on soft toys (1.38 versus 0.63 µg/g; p = 0.10). This study has shown that soft toys can harbour cat and dog allergen as well as HDM allergens, some with very high levels. Cat and dog ownership resulted in higher Fel d 1 and Can f 1 levels on soft toys and mattresses. The levels of Fel d 1, Can f 1 and HDM allergens on soft toys could be of importance to sensitized asthmatic children.

Innovative FEL schemes using variable-gap undulators

NASA Astrophysics Data System (ADS)

Schneidmiller, E. A.; Yurkov, M. V.

2017-06-01

We discuss theoretical background and experimental verification of advanced schemes for X-ray FELs using variable gap undulators (harmonic lasing self-seeded FEL, reverse taper etc.) Harmonic lasing in XFELs is an opportunity to extend operating range of existing and planned X-ray FEL user facilities. Contrary to nonlinear harmonic generation, harmonic lasing can provide much more intense, stable, and narrow-band FEL beam which is easier to handle due to the suppressed fundamental. Another interesting application of harmonic lasing is Harmonic Lasing Self-Seeded (HLSS) FEL that allows to improve longitudinal coherence and spectral power of a SASE FEL. Recently this concept was successfully tested at the soft X-ray FEL user facility FLASH in the wavelength range between 4.5 nm and 15 nm. That was also the first experimental demonstration of harmonic lasing in a high-gain FEL and at a short wavelength (before it worked only in infrared FEL oscillators). Another innovative scheme that was tested at FLASH2 is the reverse tapering that can be used to produce circularly polarized radiation from a dedicated afterburner with strongly suppressed linearly polarized radiation from the main undulator. This scheme can also be used for an efficient background-free production of harmonics in an afterburner. Experiments on the frequency doubling that allowed to reach the shortest wavelength at FLASH as well as on post-saturation tapering to produce a record intencity in XUV regime are also discussed.

Passive scalar entrainment and mixing in a forced, spatially-developing mixing layer

NASA Technical Reports Server (NTRS)

Lowery, P. S.; Reynolds, W. C.; Mansour, N. N.

1987-01-01

Numerical simulations are performed for the forced, spatially-developing plane mixing layer in two and three dimensions. Transport of a passive scalar field is included in the computation. This, together with the allowance for spatial development in the simulations, affords the opportunity for study of the asymmetric entrainment of irrotational fluid into the layer. The inclusion of a passive scalar field provides a means for simulating the effect of this entrainment asymmetry on the generation of 'products' from a 'fast' chemical reaction. Further, the three-dimensional simulations provide useful insight into the effect of streamwise structures on these entrainment and 'fast' reaction processes. Results from a two-dimensional simulation indicate 1.22 parts high-speed fluid are entrained for every one part low-speed fluid. Inclusion of streamwise vortices at the inlet plane of a three-dimensional simulation indicate a further increase in asymmetric entrainment - 1.44:1. Results from a final three-dimensional simulation are presented. In this case, a random velocity perturbation is imposed at the inlet plane. The results indicate the 'natural' development of the large spanwise structures characteristic of the mixing layer.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yan, J.; Hao, H.; Li, J. Y.

We report a systematic experimental study of a storage ring two-color free-electron laser (FEL) operating simultaneously in the infrared (IR) and ultraviolet (UV) wavelength regions. The two-color FEL lasing has been realized using a pair of dual-band high-reflectivity FEL mirrors with two different undulator configurations. We have demonstrated independent wavelength tuning in a wide range for each lasing color, as well as harmonically locked wavelength tuning when the UV lasing occurs at the second harmonic of the IR lasing. Precise power control of two-color lasing with good power stability has also been achieved. In addition, the impact of the degradationmore » of FEL mirrors on the two-color FEL operation is reported. Moreover, we have investigated the temporal structures of the two-color FEL beams, showing simultaneous two-color micropulses with their intensity modulations displayed as FEL macropulses.« less

Plasma and cyclotron frequency effects on output power of the plasma wave-pumped free-electron lasers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zolghadr, S. H.; Jafari, S., E-mail: sjafari@guilan.ac.ir; Raghavi, A.

2016-05-15

Significant progress has been made employing plasmas in the free-electron lasers (FELs) interaction region. In this regard, we study the output power and saturation length of the plasma whistler wave-pumped FEL in a magnetized plasma channel. The small wavelength of the whistler wave (in sub-μm range) in plasma allows obtaining higher radiation frequency than conventional wiggler FELs. This configuration has a higher tunability by adjusting the plasma density relative to the conventional ones. A set of coupled nonlinear differential equations is employed which governs on the self-consistent evolution of an electromagnetic wave. The electron bunching process of the whistler-pumped FELmore » has been investigated numerically. The result reveals that for a long wiggler length, the bunching factor can appreciably change as the electron beam propagates through the wiggler. The effects of plasma frequency (or plasma density) and cyclotron frequency on the output power and saturation length have been studied. Simulation results indicate that with increasing the plasma frequency, the power increases and the saturation length decreases. In addition, when density of background plasma is higher than the electron beam density (i.e., for a dense plasma channel), the plasma effects are more pronounced and the FEL-power is significantly high. It is also found that with increasing the strength of the external magnetic field frequency, the power decreases and the saturation length increases, noticeably.« less

Metallic and Ceramic Material Development Research

DTIC Science & Technology

2010-05-01

Woodward and T.A. Parthasarathy, “Experiments and Three-Dimensional Dislocation Simulations of Microplasticity in Selected Materials,” IUTAM...Parthasarathy, “Experiments and Three-Dimensional Dislocation Simulations of Microplasticity in Selected Materials,” IUTAM Conference Proceedings

Developments in the simulation of compressible inviscid and viscous flow on supercomputers

NASA Technical Reports Server (NTRS)

Steger, J. L.; Buning, P. G.

1985-01-01

In anticipation of future supercomputers, finite difference codes are rapidly being extended to simulate three-dimensional compressible flow about complex configurations. Some of these developments are reviewed. The importance of computational flow visualization and diagnostic methods to three-dimensional flow simulation is also briefly discussed.

A spatial model of wind shear and turbulence for flight simulation. Ph.D. Thesis - Colorado State Univ.

NASA Technical Reports Server (NTRS)

Campbell, C. W.

1984-01-01

A three dimensional model which combines measurements of wind shear in the real atmosphere with three dimensional Monte Carlo simulated turbulence was developed. The wind field over the body of an aircraft can be simulated and all aerodynamic loads and moments calculated.

Three dimensional, non-linear, finite element analysis of compactable soil interaction with a hyperelastic wheel

NASA Astrophysics Data System (ADS)

Chiroux, Robert Charles

The objective of this research was to produce a three dimensional, non-linear, dynamic simulation of the interaction between a hyperelastic wheel rolling over compactable soil. The finite element models developed to produce the simulation utilized the ABAQUS/Explicit computer code. Within the simulation two separate bodies were modeled, the hyperelastic wheel and a compactable soil-bed. Interaction between the bodies was achieved by allowing them to come in contact but not to penetrate the contact surface. The simulation included dynamic loading of a hyperelastic, rubber tire in contact with compactable soil with an applied constant angular velocity or torque, including a tow load, applied to the wheel hub. The constraints on the wheel model produced a straight and curved path. In addition the simulation included a shear limit between the tire and soil allowing for the introduction of slip. Soil properties were simulated using the Drucker-Prager, Cap Plasticity model available within the ABAQUS/Explicit program. Numerical results obtained from the three dimensional model were compared with related experimental data and showed good correlation for similar conditions. Numerical and experimental data compared well for both stress and wheel rut formation depth under a weight of 5.8 kN and a constant angular velocity applied to the wheel hub. The simulation results provided a demonstration of the benefit of three-dimensional simulation in comparison to previous two-dimensional, plane strain simulations.

Direct Simulation of Evolution and Control of Three-Dimensional Instabilities in Attachment-Line Boundary Layers

NASA Technical Reports Server (NTRS)

Joslin, Ronald D.

1995-01-01

The spatial evolution of three-dimensional disturbances in an attachment-line boundary layer is computed by direct numerical simulation of the unsteady, incompressible Navier-Stokes equations. Disturbances are introduced into the boundary layer by harmonic sources that involve unsteady suction and blowing through the wall. Various harmonic- source generators are implemented on or near the attachment line, and the disturbance evolutions are compared. Previous two-dimensional simulation results and nonparallel theory are compared with the present results. The three-dimensional simulation results for disturbances with quasi-two-dimensional features indicate growth rates of only a few percent larger than pure two-dimensional results; however, the results are close enough to enable the use of the more computationally efficient, two-dimensional approach. However, true three-dimensional disturbances are more likely in practice and are more stable than two-dimensional disturbances. Disturbances generated off (but near) the attachment line spread both away from and toward the attachment line as they evolve. The evolution pattern is comparable to wave packets in at-plate boundary-layer flows. Suction stabilizes the quasi-two-dimensional attachment-line instabilities, and blowing destabilizes these instabilities; these results qualitatively agree with the theory. Furthermore, suction stabilizes the disturbances that develop off the attachment line. Clearly, disturbances that are generated near the attachment line can supply energy to attachment-line instabilities, but suction can be used to stabilize these instabilities.

SYNCHROTRON RADIATION, FREE ELECTRON LASER, APPLICATION OF NUCLEAR TECHNOLOGY, ETC.: Operating the SDUV-FEL with the echo-enabled harmonic generation scheme

NASA Astrophysics Data System (ADS)

Chen, Jian-Hui; Deng, Hai-Xiao; Gu, Qiang; Li, Dong-Guo; Wang, Dong; Zhang, Meng; Zhao, Zhen-Tang

2009-08-01

Using the recently proposed echo-enabled harmonic generation (EEHG) free-electron laser (FEL) scheme, it is shown that operating the Shanghai deep ultraviolet FEL (SDUV-FEL) with single-stage to higher harmonics is very promising, with higher frequency up-conversion efficiency, higher harmonic selectivity and lower power requirement of the seed laser. The considerations on a proof-of-principle experiment and expected performance in SDUV-FEL are given.

Hypersonic Combustor Model Inlet CFD Simulations and Experimental Comparisons

NASA Technical Reports Server (NTRS)

Venkatapathy, E.; TokarcikPolsky, S.; Deiwert, G. S.; Edwards, Thomas A. (Technical Monitor)

1995-01-01

Numerous two-and three-dimensional computational simulations were performed for the inlet associated with the combustor model for the hypersonic propulsion experiment in the NASA Ames 16-Inch Shock Tunnel. The inlet was designed to produce a combustor-inlet flow that is nearly two-dimensional and of sufficient mass flow rate for large scale combustor testing. The three-dimensional simulations demonstrated that the inlet design met all the design objectives and that the inlet produced a very nearly two-dimensional combustor inflow profile. Numerous two-dimensional simulations were performed with various levels of approximations such as in the choice of chemical and physical models, as well as numerical approximations. Parametric studies were conducted to better understand and to characterize the inlet flow. Results from the two-and three-dimensional simulations were used to predict the mass flux entering the combustor and a mass flux correlation as a function of facility stagnation pressure was developed. Surface heat flux and pressure measurements were compared with the computed results and good agreement was found. The computational simulations helped determine the inlet low characteristics in the high enthalpy environment, the important parameters that affect the combustor-inlet flow, and the sensitivity of the inlet flow to various modeling assumptions.

Comparisons Of Two- And Three-Dimensional Convection In Type I X-Ray Bursts

DOE PAGES

Zingale, M.; Malone, C. M.; Nonaka, A.; ...

2015-07-01

We perform the first detailed three-dimensional simulation of low Mach number convection preceding runaway thermonuclear ignition in a mixed H/He X-ray burst. Our simulations include a moderate-sized, approximate network that captures hydrogen and helium burning up through rp-process breakout. We look at the difference between two- and three-dimensional convective fields, including the details of the turbulent convection.

Storage ring two-color free-electron laser

DOE PAGES

Yan, J.; Hao, H.; Li, J. Y.; ...

2016-07-05

We report a systematic experimental study of a storage ring two-color free-electron laser (FEL) operating simultaneously in the infrared (IR) and ultraviolet (UV) wavelength regions. The two-color FEL lasing has been realized using a pair of dual-band high-reflectivity FEL mirrors with two different undulator configurations. We have demonstrated independent wavelength tuning in a wide range for each lasing color, as well as harmonically locked wavelength tuning when the UV lasing occurs at the second harmonic of the IR lasing. Precise power control of two-color lasing with good power stability has also been achieved. In addition, the impact of the degradationmore » of FEL mirrors on the two-color FEL operation is reported. Moreover, we have investigated the temporal structures of the two-color FEL beams, showing simultaneous two-color micropulses with their intensity modulations displayed as FEL macropulses.« less

WavePropaGator: interactive framework for X-ray free-electron laser optics design and simulations.

PubMed

Samoylova, Liubov; Buzmakov, Alexey; Chubar, Oleg; Sinn, Harald

2016-08-01

This article describes the WavePropaGator ( WPG ) package, a new interactive software framework for coherent and partially coherent X-ray wavefront propagation simulations. The package has been developed at European XFEL for users at the existing and emerging free-electron laser (FEL) facilities, as well as at the third-generation synchrotron sources and future diffraction-limited storage rings. The WPG addresses the needs of beamline scientists and user groups to facilitate the design, optimization and improvement of X-ray optics to meet their experimental requirements. The package uses the Synchrotron Radiation Workshop ( SRW ) C/C++ library and its Python binding for numerical wavefront propagation simulations. The framework runs reliably under Linux, Microsoft Windows 7 and Apple Mac OS X and is distributed under an open-source license. The available tools allow for varying source parameters and optics layouts and visualizing the results interactively. The wavefront history structure can be used for tracking changes in every particular wavefront during propagation. The batch propagation mode enables processing of multiple wavefronts in workflow mode. The paper presents a general description of the package and gives some recent application examples, including modeling of full X-ray FEL beamlines and start-to-end simulation of experiments.

Development of three-dimensional hollow elastic model for cerebral aneurysm clipping simulation enabling rapid and low cost prototyping.

PubMed

Mashiko, Toshihiro; Otani, Keisuke; Kawano, Ryutaro; Konno, Takehiko; Kaneko, Naoki; Ito, Yumiko; Watanabe, Eiju

2015-03-01

We developed a method for fabricating a three-dimensional hollow and elastic aneurysm model useful for surgical simulation and surgical training. In this article, we explain the hollow elastic model prototyping method and report on the effects of applying it to presurgical simulation and surgical training. A three-dimensional printer using acrylonitrile-butadiene-styrene as a modeling material was used to produce a vessel model. The prototype was then coated with liquid silicone. After the silicone had hardened, the acrylonitrile-butadiene-styrene was melted with xylene and removed, leaving an outer layer as a hollow elastic model. Simulations using the hollow elastic model were performed in 12 patients. In all patients, the clipping proceeded as scheduled. The surgeon's postoperative assessment was favorable in all cases. This method enables easy fabrication at low cost. Simulation using the hollow elastic model is thought to be useful for understanding of three-dimensional aneurysm structure. Copyright © 2015 Elsevier Inc. All rights reserved.

40 CFR 1033.750 - Changing a locomotive's FEL at remanufacture.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Changing a locomotive's FEL at... Certification § 1033.750 Changing a locomotive's FEL at remanufacture. Locomotives are generally required to be... revised FEL for the remainder of their service lives, unless it is changed again under this section during...

40 CFR 1033.750 - Changing a locomotive's FEL at remanufacture.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Changing a locomotive's FEL at... Certification § 1033.750 Changing a locomotive's FEL at remanufacture. Locomotives are generally required to be... revised FEL for the remainder of their service lives, unless it is changed again under this section during...

Two dimensional model for coherent synchrotron radiation

NASA Astrophysics Data System (ADS)

Huang, Chengkun; Kwan, Thomas J. T.; Carlsten, Bruce E.

2013-01-01

Understanding coherent synchrotron radiation (CSR) effects in a bunch compressor requires an accurate model accounting for the realistic beam shape and parameters. We extend the well-known 1D CSR analytic model into two dimensions and develop a simple numerical model based on the Liénard-Wiechert formula for the CSR field of a coasting beam. This CSR numerical model includes the 2D spatial dependence of the field in the bending plane and is accurate for arbitrary beam energy. It also removes the singularity in the space charge field calculation present in a 1D model. Good agreement is obtained with 1D CSR analytic result for free electron laser (FEL) related beam parameters but it can also give a more accurate result for low-energy/large spot size beams and off-axis/transient fields. This 2D CSR model can be used for understanding the limitation of various 1D models and for benchmarking fully electromagnetic multidimensional particle-in-cell simulations for self-consistent CSR modeling.

Three-Dimensional Numerical Simulation of Water Quality and Sediment-Associated Processes with Application to a Mississippi Delta Lake

USDA-ARS?s Scientific Manuscript database

A three-dimensional water quality model was developed for simulating temporal and spatial variations of phytoplankton, nutrients, and dissolved oxygen in freshwater bodies. Effects of suspended and bed sediment on the water quality processes were simulated. A formula was generated from field measure...

Quantum imaging with incoherently scattered light from a free-electron laser

NASA Astrophysics Data System (ADS)

Schneider, Raimund; Mehringer, Thomas; Mercurio, Giuseppe; Wenthaus, Lukas; Classen, Anton; Brenner, Günter; Gorobtsov, Oleg; Benz, Adrian; Bhatti, Daniel; Bocklage, Lars; Fischer, Birgit; Lazarev, Sergey; Obukhov, Yuri; Schlage, Kai; Skopintsev, Petr; Wagner, Jochen; Waldmann, Felix; Willing, Svenja; Zaluzhnyy, Ivan; Wurth, Wilfried; Vartanyants, Ivan A.; Röhlsberger, Ralf; von Zanthier, Joachim

2018-02-01

The advent of accelerator-driven free-electron lasers (FEL) has opened new avenues for high-resolution structure determination via diffraction methods that go far beyond conventional X-ray crystallography methods. These techniques rely on coherent scattering processes that require the maintenance of first-order coherence of the radiation field throughout the imaging procedure. Here we show that higher-order degrees of coherence, displayed in the intensity correlations of incoherently scattered X-rays from an FEL, can be used to image two-dimensional objects with a spatial resolution close to or even below the Abbe limit. This constitutes a new approach towards structure determination based on incoherent processes, including fluorescence emission or wavefront distortions, generally considered detrimental for imaging applications. Our method is an extension of the landmark intensity correlation measurements of Hanbury Brown and Twiss to higher than second order, paving the way towards determination of structure and dynamics of matter in regimes where coherent imaging methods have intrinsic limitations.

Free electron lasers driven by linear induction accelerators: High power radiation sources

NASA Technical Reports Server (NTRS)

Orzechowski, T. J.

1989-01-01

The technology of Free Electron Lasers (FELs) and linear induction accelerators (LIAs) is addressed by outlining the following topics: fundamentals of FELs; basic concepts of linear induction accelerators; the Electron Laser Facility (a microwave FEL); PALADIN (an infrared FEL); magnetic switching; IMP; and future directions (relativistic klystrons). This presentation is represented by viewgraphs only.

Numerical simulation of the control of the three-dimensional transition process in boundary layers

NASA Technical Reports Server (NTRS)

Kral, L. D.; Fasel, H. F.

1990-01-01

Surface heating techniques to control the three-dimensional laminar-turbulent transition process are numerically investigated for a water boundary layer. The Navier-Stokes and energy equations are solved using a fully implicit finite difference/spectral method. The spatially evolving boundary layer is simulated. Results of both passive and active methods of control are shown for small amplitude two-dimensional and three-dimensional disturbance waves. Control is also applied to the early stages of the secondary instability process using passive or active control techniques.

Three- and two-dimensional simulations of counter-propagating shear experiments at high energy densities at the National Ignition Facility

DOE PAGES

Wang, Ping; Zhou, Ye; MacLaren, Stephan A.; ...

2015-11-06

Three- and two-dimensional numerical studies have been carried out to simulate recent counter-propagating shear flow experiments on the National Ignition Facility. A multi-physics three-dimensional, time-dependent radiation hydrodynamics simulation code is used. Using a Reynolds Averaging Navier-Stokes model, we show that the evolution of the mixing layer width obtained from the simulations agrees well with that measured from the experiments. A sensitivity study is conducted to illustrate a 3D geometrical effect that could confuse the measurement at late times, if the energy drives from the two ends of the shock tube are asymmetric. Implications for future experiments are discussed.

Three-dimensional microstructure simulation of Ni-based superalloy investment castings

NASA Astrophysics Data System (ADS)

Pan, Dong; Xu, Qingyan; Liu, Baicheng

2011-05-01

An integrated macro and micro multi-scale model for the three-dimensional microstructure simulation of Ni-based superalloy investment castings was developed, and applied to industrial castings to investigate grain evolution during solidification. A ray tracing method was used to deal with the complex heat radiation transfer. The microstructure evolution was simulated based on the Modified Cellular Automaton method, which was coupled with three-dimensional nested macro and micro grids. Experiments for Ni-based superalloy turbine wheel investment casting were carried out, which showed a good correspondence with the simulated results. It is indicated that the proposed model is able to predict the microstructure of the casting precisely, which provides a tool for the optimizing process.

Immunological differences in the global release of the major cat allergen Fel d 1 are influenced by sex and behaviour.

PubMed

Bienboire-Frosini, Cécile; Cozzi, Alessandro; Lafont-Lecuelle, Céline; Vervloet, Daniel; Ronin, Catherine; Pageat, Patrick

2012-07-01

The biological function of Fel d 1, the major cat allergen released in the environment, is still unclear despite studies suggesting a putative role in chemical communication. Structural and immunological polymorphisms of Fel d 1 have been described. This study examined how Fel d 1 immunological polymorphism may have a physiological origin by estimating a potential relationship with the sex of cats and cat-human interactions. Samples from bath washes of 21 cats were screened to study antibody binding to Fel d 1 using an ELISA. Personality and Tolerance Handling scores were used to assess the behaviour of the cats. In the washes, Fel d 1 concentrations were significantly lower in females than in males (P<0.05). Slopes from the ELISA dose-dependent curves varied among the cats: males secreted Fel d 1 variants with higher antibody recognition than females (P<0.01). Females that were aggressive and difficult to handle displayed a diminished slope value, and therefore a weaker Fel d 1 immunoreactivity in global washes, compared to females that were sociable (P=0.09) and easy to handle (P=0.07). This study shows a variable immunological polymorphism of Fel d 1 within a cat population, particularly between males and females, and this polymorphism appears to be related to cat-human interactions. Copyright © 2011 Elsevier Ltd. All rights reserved.

Towards short wavelengths FELs workshop

NASA Astrophysics Data System (ADS)

Ben-Zvi, I.; Winick, H.

1993-11-01

This workshop was caged because of the growing perception in the FEL source community that recent advances have made it possible to extend FEL operation to wavelengths about two orders of magnitude shorter than the 240 nm that has been achieved to date. In addition short wavelength FEL's offer the possibilities of extremely high peak power (several gigawatts) and very short pulses (of the order of 100 fs). Several groups in the USA are developing plans for such short wavelength FEL facilities. However, reviewers of these plans have pointed out that it would be highly desirable to first carry out proof-of-principle experiments at longer wavelengths to increase confidence that the shorter wavelength devices will indeed perform as calculated. The need for such experiments has now been broadly accepted by the FEL community. Such experiments were the main focus of this workshop as described in the following objectives distributed to attendees: (1) Define measurements needed to gain confidence that short wavelength FEL's will perform as calculated. (2) List possible hardware that could be used to carry out these measurements in the near term. (3) Define a prioritized FEL physics experimental program and suggested timetable. (4) Form collaborative teams to carry out this program.

The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1.

PubMed

Apostolovic, D; Sánchez-Vidaurre, S; Waden, K; Curin, M; Grundström, J; Gafvelin, G; Cirkovic Velickovic, T; Grönlund, H; Thomas, W R; Valenta, R; Hamsten, C; van Hage, M

2016-10-01

We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat- but also in dog-allergic patients. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Analysis of shot noise suppression for electron beams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ratner, Daniel; Huang, Zhirong; Stupakov, Gennady

2011-06-24

Shot noise can affect the performance of free-electron lasers (FELs) by driving instabilities (e.g., the microbunching instability) or by competing with seeded density modulations. Recent papers have proposed suppressing shot noise to enhance FEL performance. In this paper we use a onedimensional (1D) model to calculate the noise amplification from an energy modulation (e.g., electron interactions from space charge or undulator radiation) followed by a dispersive section. We show that, for a broad class of interactions, selecting the correct dispersive strength suppresses shot noise across a wide range of frequencies. The final noise level depends on the beam’s energy spreadmore » and the properties of the interaction potential. As a result, we confirm and illustrate our analytical results with 1D simulations.« less

Suppression of shot noise and spontaneous radiation in electron beams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Litvinenko,V.

2009-08-23

Shot noise in the electron beam distribution is the main source of noise in high-gain FEL amplifiers, which may affect applications ranging from single- and multi-stage HGHG FELs to an FEL amplifier for coherent electron cooling. This noise also imposes a fundamental limit of about 10{sup 6} on FEL gain, after which SASE FELs saturate. There are several advantages in strongly suppressing this shot noise in the electron beam, and the corresponding spontaneous radiation. For more than a half-century, a traditional passive method has been used successfully in practical low-energy microwave electronic devices to suppress shot noise. Recently, it wasmore » proposed for this purpose in FELs. However, being passive, the method has some significant limitations and is hardly suitable for the highly inhomogeneous beams of modern high-gain FELs. I present a novel active method of suppressing, by many orders-of-magnitude, the shot noise in relativistic electron beams. I give a theoretical description of the process, and detail its fundamental limitation.« less

Direct Numerical Simulation of a Temporally Evolving Incompressible Plane Wake: Effect of Initial Conditions on Evolution and Topology

NASA Technical Reports Server (NTRS)

Sondergaard, R.; Cantwell, B.; Mansour, N.

1997-01-01

Direct numerical simulations have been used to examine the effect of the initial disturbance field on the development of three-dimensionality and the transition to turbulence in the incompressible plane wake. The simulations were performed using a new numerical method for solving the time-dependent, three-dimensional, incompressible Navier-Stokes equations in flows with one infinite and two periodic directions. The method uses standard Fast Fourier Transforms and is applicable to cases where the vorticity field is compact in the infinite direction. Initial disturbances fields examined were combinations of two-dimensional waves and symmetric pairs of 60 deg oblique waves at the fundamental, subharmonic, and sub-subharmonic wavelengths. The results of these simulations indicate that the presence of 60 deg disturbances at the subharmonic streamwise wavelength results in the development of strong coherent three-dimensional structures. The resulting strong three-dimensional rate-of-strain triggers the growth of intense fine scale motions. Wakes initiated with 60 deg disturbances at the fundamental streamwise wavelength develop weak coherent streamwise structures, and do not develop significant fine scale motions, even at high Reynolds numbers. The wakes which develop strong three-dimensional structures exhibit growth rates on par with experimentally observed turbulent plane wakes. Wakes which develop only weak three-dimensional structures exhibit significantly lower late time growth rates. Preliminary studies of wakes initiated with an oblique fundamental and a two-dimensional subharmonic, which develop asymmetric coherent oblique structures at the subharmonic wavelength, indicate that significant fine scale motions only develop if the resulting oblique structures are above an angle of approximately 45 deg.

Molecular Dynamics Simulation of the Three-Dimensional Ordered State in Laser-Cooled Heavy-Ion Beams

NASA Astrophysics Data System (ADS)

Yuri, Yosuke

A molecular dynamics simulation is performed to study the formation of three-dimensional ordered beams by laser cooling in a cooler storage ring. Ultralow-temperature heavy-ion beams are generated by transverse cooling with displaced Gaussian lasers and resonant coupling. A three-dimensional ordered state of the ion beam is attained at a high line density. The ordered beam exhibits several unique characteristics different from those of an ideal crystalline beam.

Visualization of spatial-temporal data based on 3D virtual scene

NASA Astrophysics Data System (ADS)

Wang, Xianghong; Liu, Jiping; Wang, Yong; Bi, Junfang

2009-10-01

The main purpose of this paper is to realize the expression of the three-dimensional dynamic visualization of spatialtemporal data based on three-dimensional virtual scene, using three-dimensional visualization technology, and combining with GIS so that the people's abilities of cognizing time and space are enhanced and improved by designing dynamic symbol and interactive expression. Using particle systems, three-dimensional simulation, virtual reality and other visual means, we can simulate the situations produced by changing the spatial location and property information of geographical entities over time, then explore and analyze its movement and transformation rules by changing the interactive manner, and also replay history and forecast of future. In this paper, the main research object is the vehicle track and the typhoon path and spatial-temporal data, through three-dimensional dynamic simulation of its track, and realize its timely monitoring its trends and historical track replaying; according to visualization techniques of spatialtemporal data in Three-dimensional virtual scene, providing us with excellent spatial-temporal information cognitive instrument not only can add clarity to show spatial-temporal information of the changes and developments in the situation, but also be used for future development and changes in the prediction and deduction.

NUMERICAL SIMULATION OF THREE-DIMENSIONAL TUFT CORONA AND ELECTROHYDRODYNAMICS

EPA Science Inventory

The numerical simulation of three-dimensional tuft corona and electrohydrodynamics (EHD) is discussed. The importance of high-voltage and low-current operation in the wire-duct precipitator has focused attention on collecting high-resistivity dust. The local current density of in...

THREE-DIMENSIONAL NAPL FATE AND TRANSPORT MODEL

EPA Science Inventory

We have added several new and significant capabilities to UTCHEM to make it into a general-purpose NAPL simulator. The simulator is now capable of modeling transient and steady-state three-dimensional flow and mass transport in the groundwater (saturated) and vadose (unsaturated...

The three-dimensional evolution of a plane mixing layer. Part 1: The Kelvin-Helmholtz roll-up

NASA Technical Reports Server (NTRS)

Rogers, Michael M.; Moser, Robert D.

1991-01-01

The Kelvin Helmholtz roll up of three dimensional, temporally evolving, plane mixing layers were simulated numerically. All simulations were begun from a few low wavenumber disturbances, usually derived from linear stability theory, in addition to the mean velocity profile. The spanwise disturbance wavelength was taken to be less than or equal to the streamwise wavelength associated with the Kelvin Helmholtz roll up. A standard set of clean structures develop in most of the simulations. The spanwise vorticity rolls up into a corrugated spanwise roller, with vortex stretching creating strong spanwise vorticity in a cup shaped region at the vends of the roller. Predominantly streamwise rib vortices develop in the braid region between the rollers. For sufficiently strong initial three dimensional disturbances, these ribs collapse into compact axisymmetric vortices. The rib vortex lines connect to neighboring ribs and are kinked in the opposite direction of the roller vortex lines. Because of this, these two sets of vortex lines remain distinct. For certain initial conditions, persistent ribs do not develop. In such cases the development of significant three dimensionality is delayed. When the initial three dimensional disturbance energy is about equal to, or less than, the two dimensional fundamental disturbance energy, the evolution of the three dimensional disturbance is nearly linear (with respect to the mean and the two dimensional disturbances), at least until the first Kelvin Helmholtz roll up is completed.

Sensitization to minor cat allergen components is associated with type-2 biomarkers in young asthmatics.

PubMed

Tsolakis, N; Malinovschi, A; Nordvall, L; Mattsson, L; Lidholm, J; Pedroletti, C; Janson, C; Borres, M P; Alving, K

2018-03-25

Cat allergy is a major trigger of asthma world-wide. Molecular patterns of cat sensitization vary between individuals, but their relationship to inflammation in asthmatics has not been extensively studied. To investigate the prevalence and levels of IgE antibodies against different cat allergen components and their relationship to type-2 inflammation and total IgE among young asthmatic subjects sensitized to furry animals. Patients with asthma (age 10-35 years; n = 266) and IgE sensitization to cat, dog or horse extract (ImmunoCAP), were analysed for IgE to the cat allergen components Fel d 1 (secretoglobin), Fel d 2 (serum albumin), Fel d 4 and Fel d 7 (lipocalins). Independent associations between IgE-antibody concentrations, and fraction of exhaled nitric oxide (FeNO), blood eosinophil (B-Eos) count, and total IgE were analysed by multiple linear regression after adjustment for possible confounders. The level of IgE against Fel d 2 was independently related to FeNO (P = .012) and total IgE (P < .001), and IgE against Fel d 4 associated with Β-Eos count (P = .009) and total IgE (P < .001). IgE antibodies against Fel d 1 or cat extract did not independently relate to these inflammatory markers (P = .23-.51). Levels of IgE to lipocalin (Fel d 4) and serum albumin (Fel d 2), but not to secretoglobin (Fel d 1) or cat extract, were independently associated with type-2 biomarkers and total IgE in young asthmatics. We suggest that measurement of IgE to minor cat allergen components may be useful when investigating asthma morbidity in cat allergic subjects. © 2018 John Wiley & Sons Ltd.

Validation and application of a two-dimensional model to simulate soil salt transport under mulched drip irrigation

NASA Astrophysics Data System (ADS)

Jiao, Huiqing; Zhao, Chengyi; Sheng, Yu; Chen, Yan; Shi, Jianchu; Li, Baoguo

2017-04-01

Water shortage and soil salinization increasingly become the main constraints for sustainable development of agriculture in Southern Xinjiang, China. Mulched drip irrigation, as a high-efficient water-saving irrigation method, has been widely applied in Southern Xinjiang for cotton production. In order to analyze the reasonability of describing the three-dimensional soil water and salt transport processes under mulched drip irrigation with a relatively simple two-dimensional model, a field experiment was conducted from 2007 to 2015 at Aksu of Southern Xinjiang, and soil water and salt transport processes were simulated through the three-dimensional and two-dimensional models based on COMSOL. Obvious differences were found between three-dimensional and two-dimensional simulations for soil water flow within the early 12 h of irrigation event and for soil salt transport in the area within 15 cm away from drip tubes during the whole irrigation event. The soil water and salt contents simulated by the two-dimensional model, however, agreed well with the mean values between two adjacent emitters simulated by the three-dimensional model, and also coincided with the measurements as corresponding RMSE less than 0.037 cm3 cm-3 and 1.80 g kg-1, indicating that the two-dimensional model was reliable for field irrigation management. Subsequently, the two-dimensional model was applied to simulate the dynamics of soil salinity for five numerical situations and for a widely adopted irrigation pattern in Southern Xinjiang (about 350 mm through mulched drip irrigation during growing season of cotton and total 400 mm through flooding irrigations before sowing and after harvesting). The simulation results indicated that the contribution of transpiration to salt accumulation in root layer was about 75% under mulched drip irrigation. Moreover, flooding irrigations before sowing and after harvesting were of great importance for salt leaching of arable layer, especially in bare strip where drip irrigation water hardly reached, and thus providing suitable root zone environment for cotton. Nevertheless, flooding irrigation should be further optimized to enhance water use efficiency.

Medical free-electron laser: fact or fiction?

NASA Astrophysics Data System (ADS)

Bell, James P.; Ponikvar, Donald R.

1994-07-01

The free electron laser (FEL) has long been proposed as a flexible tool for a variety of medical applications, and yet the FEL has not seen widespread acceptance in the medical community. The issues have been the laser's size, cost, and complexity. Unfortunately, research on applications of FELs has outpaced the device development efforts. This paper describes the characteristics of the FEL, as they have been demonstrated in the U.S. Army's FEL technology development program, and identifies specific medical applications where demonstrated performance levels would suffice. This includes new photodynamic therapies for cancer and HIV treatment, orthopedic applications, tissue welding applications, and multiwavelength surgical techniques. A new tunable kilowatt class FEL device is described, which utilizes existing hardware from the U.S. Army program. An assessment of the future potential, based on realistic technology scaling is provided.

Comparing an optical parametric oscillator (OPO) as a viable alternative for mid-infrared tissue ablation with a free electron laser (FEL).

PubMed

Mackanos, Mark A; Simanovskii, Dmitrii M; Contag, Christopher H; Kozub, John A; Jansen, E Duco

2012-11-01

Beneficial medical laser ablation removes material efficiently with minimal collateral damage. A Mark-III free electron laser (FEL), at a wavelength of 6.45 μm has demonstrated minimal damage and high ablation yield in ocular and neural tissues. While this wavelength has shown promise for surgical applications, further advances are limited by the high overhead for FEL use. Alternative mid-infrared sources are needed for further development. We compared the FEL with a 5-μs pulse duration with a Q-switched ZGP-OPO with a 100-ns pulse duration at mid-infrared wavelengths. There were no differences in the ablation threshold of water and mouse dermis with these two sources in spite of the difference in their pulse structures. There was a significant difference in crater depth between the ZGP:OPO and the FEL. At 6.1 μm, the OPO craters are eight times the depth of the FEL craters. The OPO craters at 6.45 and 6.73 μm were six and five times the depth of the FEL craters, respectively. Bright-field (pump-probe) images showed the classic ablation mechanism from formation of a plume through collapse and recoil. The crater formation, ejection, and collapse phases occurred on a faster time-scale with the OPO than with the FEL. This research showed that a ZGP-OPO laser could be a viable alternative to FEL for clinical applications.

NAPL: SIMULATOR DOCUMENTATION

EPA Science Inventory

A mathematical and numerical model is developed to simulate the transport and fate of NAPLs (Non-Aqueous Phase Liquids) in near-surface granular soils. The resulting three-dimensional, three phase simulator is called NAPL. The simulator accommodates three mobile phases: water, NA...

40 CFR 1037.645 - In-use compliance with family emission limits (FELs).

Code of Federal Regulations, 2013 CFR

2013-07-01

... different FELs, we may apply a higher FEL within the family than was applied to the vehicle's configuration... of 200 g/ton-mile, 210 g/ton-mile, and 220 g/ton-mile, we may apply a 220 g/ton-mile in-use FEL to vehicles that were originally designated as part of the 200 g/ton-mile or 210 g/ton-mile sub-families. (2...

40 CFR 1037.645 - In-use compliance with family emission limits (FELs).

Code of Federal Regulations, 2012 CFR

2012-07-01

... different FELs, we may apply a higher FEL within the family than was applied to the vehicle's configuration... of 200 g/ton-mile, 210 g/ton-mile, and 220 g/ton-mile, we may apply a 220 g/ton-mile in-use FEL to vehicles that were originally designated as part of the 200 g/ton-mile or 210 g/ton-mile sub-families. (2...

40 CFR 1037.645 - In-use compliance with family emission limits (FELs).

Code of Federal Regulations, 2014 CFR

2014-07-01

... different FELs, we may apply a higher FEL within the family than was applied to the vehicle's configuration... of 200 g/ton-mile, 210 g/ton-mile, and 220 g/ton-mile, we may apply a 220 g/ton-mile in-use FEL to vehicles that were originally designated as part of the 200 g/ton-mile or 210 g/ton-mile sub-families. (2...

High-power free-electron lasers-technology and future applications

NASA Astrophysics Data System (ADS)

Socol, Yehoshua

2013-03-01

Free-electron laser (FEL) is an all-electric, high-power, high beam-quality source of coherent radiation, tunable - unlike other laser sources - at any wavelength within wide spectral region from hard X-rays to far-IR and beyond. After the initial push in the framework of the “Star Wars” program, the FEL technology benefited from decades of R&D and scientific applications. Currently, there are clear signs that the FEL technology reached maturity, enabling real-world applications. E.g., successful and unexpectedly smooth commissioning of the world-first X-ray FEL in 2010 increased in one blow by more than an order of magnitude (40×) wavelength region available by FEL technology and thus demonstrated that the theoretical predictions just keep true in real machines. Experience of ordering turn-key electron beamlines from commercial companies is a further demonstration of the FEL technology maturity. Moreover, successful commissioning of the world-first multi-turn energy-recovery linac demonstrated feasibility of reducing FEL size, cost and power consumption by probably an order of magnitude in respect to previous configurations, opening way to applications, previously considered as non-feasible. This review takes engineer-oriented approach to discuss the FEL technology issues, keeping in mind applications in the fields of military and aerospace, next generation semiconductor lithography, photo-chemistry and isotope separation.

Fully three-dimensional direct numerical simulation of a plunging breaker

NASA Astrophysics Data System (ADS)

Lubin, Pierre; Vincent, Stéphane; Caltagirone, Jean-Paul; Abadie, Stéphane

2003-07-01

The scope of this paper is to show the results obtained for simulating three-dimensional breaking waves by solving the Navier-Stokes equations in air and water. The interface tracking is achieved by a Lax-Wendroff TVD scheme (Total Variation Diminishing), which is able to handle interface reconnections. We first present the equations and the numerical methods used in this work. We then proceed to the study of a three-dimensional plunging breaking wave, using initial conditions corresponding to unstable periodic sinusoidal waves of large amplitudes. We compare the results obtained for two simulations, a longshore depth perturbation has been introduced in the solution of the flow equations in order to see the transition from a two-dimensional velocity field to a fully three-dimensional one after plunging. Breaking processes including overturning, splash-up and breaking induced vortex-like motion beneath the surface are presented and discussed. To cite this article: P. Lubin et al., C. R. Mecanique 331 (2003).

A VERSATILE SHARP INTERFACE IMMERSED BOUNDARY METHOD FOR INCOMPRESSIBLE FLOWS WITH COMPLEX BOUNDARIES

PubMed Central

Mittal, R.; Dong, H.; Bozkurttas, M.; Najjar, F.M.; Vargas, A.; von Loebbecke, A.

2010-01-01

A sharp interface immersed boundary method for simulating incompressible viscous flow past three-dimensional immersed bodies is described. The method employs a multi-dimensional ghost-cell methodology to satisfy the boundary conditions on the immersed boundary and the method is designed to handle highly complex three-dimensional, stationary, moving and/or deforming bodies. The complex immersed surfaces are represented by grids consisting of unstructured triangular elements; while the flow is computed on non-uniform Cartesian grids. The paper describes the salient features of the methodology with special emphasis on the immersed boundary treatment for stationary and moving boundaries. Simulations of a number of canonical two- and three-dimensional flows are used to verify the accuracy and fidelity of the solver over a range of Reynolds numbers. Flow past suddenly accelerated bodies are used to validate the solver for moving boundary problems. Finally two cases inspired from biology with highly complex three-dimensional bodies are simulated in order to demonstrate the versatility of the method. PMID:20216919

Three-dimensional numerical simulations of local scouring around bridge piers

USDA-ARS?s Scientific Manuscript database

This paper presents a novel numerical method for simulating local scouring around bridge piers using a three-dimensional free-surface RANS turbulent flow model. Strong turbulent fluctuations and the down-flows around the bridge pier are considered important factors in scouring the bed. The turbulent...

Technological Challenges to X-Ray FELs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nuhn, Heinz-Dieter

1999-09-16

There is strong interest in the development of x-ray free electron lasers (x-ray FELs). The interest is driven by the scientific opportunities provided by intense, coherent x-rays. An x-ray FEL has all the characteristics of a fourth-generation source: brightness several orders of magnitude greater than presently achieved in third-generation sources, full transverse coherence, and sub-picosecond long pulses. The SLAC and DESY laboratories have presented detailed design studies for X-Ray FEL user facilities around the 0.1 nm wavelength-regime (LCLS at SLAC, TESLA X-Ray FEL at DESY). Both laboratories are engaged in proof-of-principle experiments are longer wavelengths (TTF FEL Phase I atmore » 71 nm, VISA at 600-800 nm) with results expected in 1999. The technologies needed to achieve the proposed performances are those of bright electron sources, of acceleration systems capable of preserving the brightness of the source, and of undulators capable of meeting the magnetic and mechanical tolerances that are required for operation in the SASE mode. This paper discusses the technological challenges presented by the X-Ray FEL projects.« less

Three-Dimensional Computational Model for Flow in an Over-Expanded Nozzle With Porous Surfaces

NASA Technical Reports Server (NTRS)

Abdol-Hamid, K. S.; Elmiligui, Alaa; Hunter, Craig A.; Massey, Steven J.

2006-01-01

A three-Dimensional computational model is used to simulate flow in a non-axisymmetric, convergent-divergent nozzle incorporating porous cavities for shock-boundary layer interaction control. The nozzle has an expansion ratio (exit area/throat area) of 1.797 and a design nozzle pressure ratio of 8.78. Flow fields for the baseline nozzle (no porosity) and for the nozzle with porous surfaces of 10% openness are computed for Nozzle Pressure Ratio (NPR) varying from 1.29 to 9.54. The three dimensional computational results indicate that baseline (no porosity) nozzle performance is dominated by unstable, shock-induced, boundary-layer separation at over-expanded conditions. For NPR less than or equal to 1.8, the separation is three dimensional, somewhat unsteady, and confined to a bubble (with partial reattachment over the nozzle flap). For NPR greater than or equal to 2.0, separation is steady and fully detached, and becomes more two dimensional as NPR increased. Numerical simulation of porous configurations indicates that a porous patch is capable of controlling off design separation in the nozzle by either alleviating separation or by encouraging stable separation of the exhaust flow. In the present paper, computational simulation results, wall centerline pressure, mach contours, and thrust efficiency ratio are presented, discussed and compared with experimental data. Results indicate that comparisons are in good agreement with experimental data. The three-dimensional simulation improves the comparisons for over-expanded flow conditions as compared with two-dimensional assumptions.

A heterogeneous computing environment for simulating astrophysical fluid flows

NASA Technical Reports Server (NTRS)

Cazes, J.

1994-01-01

In the Concurrent Computing Laboratory in the Department of Physics and Astronomy at Louisiana State University we have constructed a heterogeneous computing environment that permits us to routinely simulate complicated three-dimensional fluid flows and to readily visualize the results of each simulation via three-dimensional animation sequences. An 8192-node MasPar MP-1 computer with 0.5 GBytes of RAM provides 250 MFlops of execution speed for our fluid flow simulations. Utilizing the parallel virtual machine (PVM) language, at periodic intervals data is automatically transferred from the MP-1 to a cluster of workstations where individual three-dimensional images are rendered for inclusion in a single animation sequence. Work is underway to replace executions on the MP-1 with simulations performed on the 512-node CM-5 at NCSA and to simultaneously gain access to more potent volume rendering workstations.

Method for separating FEL output beams from long wavelength radiation

DOEpatents

Neil, George; Shinn, Michelle D.; Gubeli, Joseph

2016-04-26

A method for improving the output beam quality of a free electron laser (FEL) by reducing the amount of emission at wavelengths longer than the electron pulse length and reducing the amount of edge radiation. A mirror constructed of thermally conductive material and having an aperture therein is placed at an oblique angle with respect to the beam downstream of the bending magnet but before any sensitive use of the FEL beam. The aperture in the mirror is sized to deflect emission longer than the wavelength of the FEL output while having a minor impact on the FEL output beam. A properly sized aperture will enable the FEL radiation, which is coherent and generally at a much shorter wavelength than the bending radiations, to pass through the aperture mirror. The much higher divergence bending radiations will subsequently strike the aperture mirror and be reflected safely out of the way.

High-power infrared and ultraviolet free electron lasers at CEBAF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Byung Yunn; Charles Sinclair; Christoph Leemann

1992-06-15

In response to requirements for national laboratory technology transfer, CEBAF has proposed an industrial R&D initiative: a Free Electron Laser(FEL) User Facility based on an infrared FEL and an ultraviolet FEL, with the injector and the north linac of the CEBAF superconducting,recirculating accelerator serving as drivers. The initiative is a collaborative effort with four U.S. corporate partners and capitalizes on CEBAF'ssuperconducting rf technology. The FELs will provide monochromatic, tunable (3.6 to 1.7 ¿m and 150 to 260 nm), high-average-power (-kW) lightfor technical applications and basic science studies. FEL capabilities will be competitive with those of similar initiatives worldwide. FEL operationmore » willnot impair beam delivered to CEBAF's nuclear physics experiments. Substational commitments are in hand from the industray partners and theCommonwealth of Virgina for cost-sharing the project with the Federal Government.« less

High-power infrared and ultraviolet free electron lasers at CEBAF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dylla, H.F.; Bisognano, J.J.; Douglas, D.

1992-12-05

In response to requirements for national laboratory technology transfer, CEBAF has proposed an industrial R D initiative: a Free Electron Laser (FEL) User Facility based on an infrared FEL and an ultraviolet FEL, with the injector and the north linac of the CEBAF superconducting, recirculating accelerator serving as drivers. The initiative is a collaborative effort with four U.S. corporate partners and capitalizes on CEBAF's superconducting rf technology. The FELs will provide monochromatic, tunable (3.6 to 1.7 [mu]m and 150 to 260 nm), high-average-power (-kW) light for technical applications and basic science studies. FEL capabilities will be competitive with those ofmore » similar initiatives worldwide. FEL operation will not impair beam delivered to CEBAF's nuclear physics experiments. Substational commitments are in hand from the industray partners and the Commonwealth of Virgina for cost-sharing the project with the Federal Government.« less

Widely tunable two-colour seeded free-electron laser source for resonant-pump resonant-probe magnetic scattering

PubMed Central

Ferrari, Eugenio; Spezzani, Carlo; Fortuna, Franck; Delaunay, Renaud; Vidal, Franck; Nikolov, Ivaylo; Cinquegrana, Paolo; Diviacco, Bruno; Gauthier, David; Penco, Giuseppe; Ribič, Primož Rebernik; Roussel, Eleonore; Trovò, Marco; Moussy, Jean-Baptiste; Pincelli, Tommaso; Lounis, Lounès; Manfredda, Michele; Pedersoli, Emanuele; Capotondi, Flavio; Svetina, Cristian; Mahne, Nicola; Zangrando, Marco; Raimondi, Lorenzo; Demidovich, Alexander; Giannessi, Luca; De Ninno, Giovanni; Danailov, Miltcho Boyanov; Allaria, Enrico; Sacchi, Maurizio

2016-01-01

The advent of free-electron laser (FEL) sources delivering two synchronized pulses of different wavelengths (or colours) has made available a whole range of novel pump–probe experiments. This communication describes a major step forward using a new configuration of the FERMI FEL-seeded source to deliver two pulses with different wavelengths, each tunable independently over a broad spectral range with adjustable time delay. The FEL scheme makes use of two seed laser beams of different wavelengths and of a split radiator section to generate two extreme ultraviolet pulses from distinct portions of the same electron bunch. The tunability range of this new two-colour source meets the requirements of double-resonant FEL pump/FEL probe time-resolved studies. We demonstrate its performance in a proof-of-principle magnetic scattering experiment in Fe–Ni compounds, by tuning the FEL wavelengths to the Fe and Ni 3p resonances. PMID:26757813

Modeling and numerical simulations of growth and morphologies of three dimensional aggregated silver films

NASA Astrophysics Data System (ADS)

Davis, L. J.; Boggess, M.; Kodpuak, E.; Deutsch, M.

2012-11-01

We report on a model for the deposition of three dimensional, aggregated nanocrystalline silver films, and an efficient numerical simulation method developed for visualizing such structures. We compare our results to a model system comprising chemically deposited silver films with morphologies ranging from dilute, uniform distributions of nanoparticles to highly porous aggregated networks. Disordered silver films grown in solution on silica substrates are characterized using digital image analysis of high resolution scanning electron micrographs. While the latter technique provides little volume information, plane-projected (two dimensional) island structure and surface coverage may be reliably determined. Three parameters governing film growth are evaluated using these data and used as inputs for the deposition model, greatly reducing computing requirements while still providing direct access to the complete (bulk) structure of the films throughout the growth process. We also show how valuable three dimensional characteristics of the deposited materials can be extracted using the simulated structures.

Direct numerical simulation of the laminar-turbulent transition at hypersonic flow speeds on a supercomputer

NASA Astrophysics Data System (ADS)

Egorov, I. V.; Novikov, A. V.; Fedorov, A. V.

2017-08-01

A method for direct numerical simulation of three-dimensional unsteady disturbances leading to a laminar-turbulent transition at hypersonic flow speeds is proposed. The simulation relies on solving the full three-dimensional unsteady Navier-Stokes equations. The computational technique is intended for multiprocessor supercomputers and is based on a fully implicit monotone approximation scheme and the Newton-Raphson method for solving systems of nonlinear difference equations. This approach is used to study the development of three-dimensional unstable disturbances in a flat-plate and compression-corner boundary layers in early laminar-turbulent transition stages at the free-stream Mach number M = 5.37. The three-dimensional disturbance field is visualized in order to reveal and discuss features of the instability development at the linear and nonlinear stages. The distribution of the skin friction coefficient is used to detect laminar and transient flow regimes and determine the onset of the laminar-turbulent transition.

Experimental evidence for short-pulse laser heating of solid-density target to high bulk temperatures.

PubMed

Soloviev, A; Burdonov, K; Chen, S N; Eremeev, A; Korzhimanov, A; Pokrovskiy, G V; Pikuz, T A; Revet, G; Sladkov, A; Ginzburg, V; Khazanov, E; Kuzmin, A; Osmanov, R; Shaikin, I; Shaykin, A; Yakovlev, I; Pikuz, S; Starodubtsev, M; Fuchs, J

2017-09-22

Heating efficiently solid-density, or even compressed, matter has been a long-sought goal in order to allow investigation of the properties of such state of matter of interest for various domains, e.g. astrophysics. High-power lasers, pinches, and more recently Free-Electron-Lasers (FELs) have been used in this respect. Here we show that by using the high-power, high-contrast "PEARL" laser (Institute of Applied Physics-Russian Academy of Science, Nizhny Novgorod, Russia) delivering 7.5 J in a 60 fs laser pulse, such coupling can be efficiently obtained, resulting in heating of a slab of solid-density Al of 0.8 µm thickness at a temperature of 300 eV, and with minimal density gradients. The characterization of the target heating is achieved combining X-ray spectrometry and measurement of the protons accelerated from the Al slab. The measured heating conditions are consistent with a three-temperatures model that simulates resistive and collisional heating of the bulk induced by the hot electrons. Such effective laser energy deposition is achieved owing to the intrinsic high contrast of the laser which results from the Optical Parametric Chirped Pulse Amplification technology it is based on, allowing to attain high target temperatures in a very compact manner, e.g. in comparison with large-scale FEL facilities.

Generation of subterawatt-attosecond pulses in a soft x-ray free-electron laser

DOE PAGES

Huang, Senlin; Ding, Yuantao; Huang, Zhirong; ...

2016-08-15

Here, we propose a novel scheme to generate attosecond soft x rays in a self-seeded free-electron laser (FEL) suitable for enabling attosecond spectroscopic investigations. A time-energy chirped electron bunch with additional sinusoidal energy modulation is adopted to produce a short seed pulse through a self-seeding monochromator. This short seed pulse, together with high electron current spikes and a cascaded delay setup, enables a high-efficiency FEL with a fresh bunch scheme. Simulations show that using the Linac Coherent Light Source (LCLS) parameters, soft x-ray pulses with a FWHM of 260 attoseconds and a peak power of 0.5 TW can be obtained.more » This scheme also has the feature of providing a stable central wavelength determined by the self-seeding monochromator.« less

Dispersion relation and growth rate of a relativistic electron beam propagating through a Langmuir wave wiggler

NASA Astrophysics Data System (ADS)

Zirak, H.; Jafari, S.

2015-06-01

In this study, a theory of free-electron laser (FEL) with a Langmuir wave wiggler in the presence of an axial magnetic field has been presented. The small wavelength of the plasma wave (in the sub-mm range) allows obtaining higher frequency than conventional wiggler FELs. Electron trajectories have been obtained by solving the equations of motion for a single electron. In addition, a fourth-order Runge-Kutta method has been used to simulate the electron trajectories. Employing a perturbation analysis, the dispersion relation for an electromagnetic and space-charge waves has been derived by solving the momentum transfer, continuity, and wave equations. Numerical calculations show that the growth rate increases with increasing the e-beam energy and e-beam density, while it decreases with increasing the strength of the axial guide magnetic field.

Energy sweep compensation of induction accelerators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sampayan, S.E.; Caporaso, G.J.; Chen, Y-J

1990-09-12

The ETA-II linear induction accelerator (LIA) is designed to drive a microwave free electron laser (FEL). Beam energy sweep must be limited to {plus minus}1% for 50 ns to limit beam corkscrew motion and ensure high power FEL output over the full duration of the beam flattop. To achieve this energy sweep requirement, we have implemented a pulse distribution system and are planning implementation of a tapered pulse forming line (PFL) in the pulse generators driving acceleration gaps. The pulse distribution system assures proper phasing of the high voltage pulse to the electron beam. Additionally, cell-to-cell coupling of beam inducedmore » transients is reduced. The tapered PFL compensates for accelerator cell and loading nonlinearities. Circuit simulations show good agreement with preliminary data and predict the required energy sweep requirement can be met.« less

Extracting Galaxy Cluster Gas Inhomogeneity from X-Ray Surface Brightness: A Statistical Approach and Application to Abell 3667

NASA Astrophysics Data System (ADS)

Kawahara, Hajime; Reese, Erik D.; Kitayama, Tetsu; Sasaki, Shin; Suto, Yasushi

2008-11-01

Our previous analysis indicates that small-scale fluctuations in the intracluster medium (ICM) from cosmological hydrodynamic simulations follow the lognormal probability density function. In order to test the lognormal nature of the ICM directly against X-ray observations of galaxy clusters, we develop a method of extracting statistical information about the three-dimensional properties of the fluctuations from the two-dimensional X-ray surface brightness. We first create a set of synthetic clusters with lognormal fluctuations around their mean profile given by spherical isothermal β-models, later considering polytropic temperature profiles as well. Performing mock observations of these synthetic clusters, we find that the resulting X-ray surface brightness fluctuations also follow the lognormal distribution fairly well. Systematic analysis of the synthetic clusters provides an empirical relation between the three-dimensional density fluctuations and the two-dimensional X-ray surface brightness. We analyze Chandra observations of the galaxy cluster Abell 3667, and find that its X-ray surface brightness fluctuations follow the lognormal distribution. While the lognormal model was originally motivated by cosmological hydrodynamic simulations, this is the first observational confirmation of the lognormal signature in a real cluster. Finally we check the synthetic cluster results against clusters from cosmological hydrodynamic simulations. As a result of the complex structure exhibited by simulated clusters, the empirical relation between the two- and three-dimensional fluctuation properties calibrated with synthetic clusters when applied to simulated clusters shows large scatter. Nevertheless we are able to reproduce the true value of the fluctuation amplitude of simulated clusters within a factor of 2 from their two-dimensional X-ray surface brightness alone. Our current methodology combined with existing observational data is useful in describing and inferring the statistical properties of the three-dimensional inhomogeneity in galaxy clusters.

A three-dimensional Dirichlet-to-Neumann operator for water waves over topography

NASA Astrophysics Data System (ADS)

Andrade, D.; Nachbin, A.

2018-06-01

Surface water waves are considered propagating over highly variable non-smooth topographies. For this three dimensional problem a Dirichlet-to-Neumann (DtN) operator is constructed reducing the numerical modeling and evolution to the two dimensional free surface. The corresponding Fourier-type operator is defined through a matrix decomposition. The topographic component of the decomposition requires special care and a Galerkin method is provided accordingly. One dimensional numerical simulations, along the free surface, validate the DtN formulation in the presence of a large amplitude, rapidly varying topography. An alternative, conformal mapping based, method is used for benchmarking. A two dimensional simulation in the presence of a Luneburg lens (a particular submerged mound) illustrates the accurate performance of the three dimensional DtN operator.

Accuracy of three-dimensional seismic ground response analysis in time domain using nonlinear numerical simulations

NASA Astrophysics Data System (ADS)

Liang, Fayun; Chen, Haibing; Huang, Maosong

2017-07-01

To provide appropriate uses of nonlinear ground response analysis for engineering practice, a three-dimensional soil column with a distributed mass system and a time domain numerical analysis were implemented on the OpenSees simulation platform. The standard mesh of a three-dimensional soil column was suggested to be satisfied with the specified maximum frequency. The layered soil column was divided into multiple sub-soils with a different viscous damping matrix according to the shear velocities as the soil properties were significantly different. It was necessary to use a combination of other one-dimensional or three-dimensional nonlinear seismic ground analysis programs to confirm the applicability of nonlinear seismic ground motion response analysis procedures in soft soil or for strong earthquakes. The accuracy of the three-dimensional soil column finite element method was verified by dynamic centrifuge model testing under different peak accelerations of the earthquake. As a result, nonlinear seismic ground motion response analysis procedures were improved in this study. The accuracy and efficiency of the three-dimensional seismic ground response analysis can be adapted to the requirements of engineering practice.

Special issue on compact x-ray sources

NASA Astrophysics Data System (ADS)

Hooker, Simon; Midorikawa, Katsumi; Rosenzweig, James

2014-04-01

Journal of Physics B: Atomic, Molecular and Optical Physics is delighted to announce a forthcoming special issue on compact x-ray sources, to appear in the winter of 2014, and invites you to submit a paper. The potential for high-brilliance x- and gamma-ray sources driven by advanced, compact accelerators has gained increasing attention in recent years. These novel sources—sometimes dubbed 'fifth generation sources'—will build on the revolutionary advance of the x-ray free-electron laser (FEL). New radiation sources of this type have widespread applications, including in ultra-fast imaging, diagnostic and therapeutic medicine, and studies of matter under extreme conditions. Rapid advances in compact accelerators and in FEL techniques make this an opportune moment to consider the opportunities which could be realized by bringing these two fields together. Further, the successful development of compact radiation sources driven by compact accelerators will be a significant milestone on the road to the development of high-gradient colliders able to operate at the frontiers of particle physics. Thus the time is right to publish a peer-reviewed collection of contributions concerning the state-of-the-art in: advanced and novel acceleration techniques; sophisticated physics at the frontier of FELs; and the underlying and enabling techniques of high brightness electron beam physics. Interdisciplinary research connecting two or more of these fields is also increasingly represented, as exemplified by entirely new concepts such as plasma based electron beam sources, and coherent imaging with fs-class electron beams. We hope that in producing this special edition of Journal of Physics B: Atomic, Molecular and Optical Physics (iopscience.iop.org/0953-4075/) we may help further a challenging mission and ongoing intellectual adventure: the harnessing of newly emergent, compact advanced accelerators to the creation of new, agile light sources with unprecedented capabilities. New schemes for compact accelerators: laser- and beam-driven plasma accelerators; dielectric laser accelerators; THz accelerators. Latest results for compact accelerators. Target design and staging of advanced accelerators. Advanced injection and phase space manipulation techniques. Novel diagnostics: single-shot measurement of sub-fs bunch duration; measurement of ultra-low emittance. Generation and characterization of incoherent radiation: betatron and undulator radiation; Thomson/Compton scattering sources, novel THz sources. Generation and characterization of coherent radiation. Novel FEL simulation techniques. Advances in simulations of novel accelerators: simulations of injection and acceleration processes; simulations of coherent and incoherent radiation sources; start-to-end simulations of fifth generation light sources. Novel undulator schemes. Novel laser drivers for laser-driven accelerators: high-repetition rate laser systems; high wall-plug efficiency systems. Applications of compact accelerators: imaging; radiography; medical applications; electron diffraction and microscopy. Please submit your article by 15 May 2014 (expected web publication: winter 2014); submissions received after this date will be considered for the journal, but may not be included in the special issue.

Saturation Measurements of a Visible SASE FEL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carr, Roger

2002-08-14

VISA (Visible to Infrared SASE Amplifier) is an FEL designed to obtain high gain at a radiation wavelength of 800 nm. Large gain is achieved by driving the FEL with the 71 MeV, high brightness beam of the Accelerator Test Facility (ATF) and using a novel, strong focusing, 4 m long undulator with a gap of 6 mm and a period of 1.8 cm. We report measurements of exponential gain, saturation, and spectra of the FEL radiation intensity.

On the construction of a direct numerical simulation of a breaking inertia-gravity wave in the upper mesosphere

NASA Astrophysics Data System (ADS)

Fruman, Mark D.; Remmler, Sebastian; Achatz, Ulrich; Hickel, Stefan

2014-10-01

A systematic approach to the direct numerical simulation (DNS) of breaking upper mesospheric inertia-gravity waves of amplitude close to or above the threshold for static instability is presented. Normal mode or singular vector analysis applied in a frame of reference moving with the phase velocity of the wave (in which the wave is a steady solution) is used to determine the most likely scale and structure of the primary instability and to initialize nonlinear "2.5-D" simulations (with three-dimensional velocity and vorticity fields but depending only on two spatial coordinates). Singular vector analysis is then applied to the time-dependent 2.5-D solution to predict the transition of the breaking event to three-dimensional turbulence and to initialize three-dimensional DNS. The careful choice of the computational domain and the relatively low Reynolds numbers, on the order of 25,000, relevant to breaking waves in the upper mesosphere, makes the three-dimensional DNS tractable with present-day computing clusters. Three test cases are presented: a statically unstable low-frequency inertia-gravity wave, a statically and dynamically stable inertia-gravity wave, and a statically unstable high-frequency gravity wave. The three-dimensional DNS are compared to ensembles of 2.5-D simulations. In general, the decay of the wave and generation of turbulence is faster in three dimensions, but the results are otherwise qualitatively and quantitatively similar, suggesting that results of 2.5-D simulations are meaningful if the domain and initial condition are chosen properly.

Airborne megawatt class free-electron laser for defense and security

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roy Whitney; David Douglas; George Neil

2005-03-01

An airborne megawatt (MW) average power Free-Electron Laser (FEL) is now a possibility. In the process of shrinking the FEL parameters to fit on ship, a surprisingly lightweight and compact design has been achieved. There are multiple motivations for using a FEL for a high-power airborne system for Defense and Security: Diverse mission requirements can be met by a single system. The MW of light can be made available with any time structure for time periods from microseconds to hours, i.e. there is a nearly unlimited magazine. The wavelength of the light can be chosen to be from the farmore » infrared (IR) to the near ultraviolet (UV) thereby best meeting mission requirements. The FEL light can be modulated for detecting the same pattern in the small fraction of light reflected from the target resulting in greatly enhanced targeting control. The entire MW class FEL including all of its subsystems can be carried by large commercial size airplanes or on an airship. Adequate electrical power can be generated on the plane or airship to run the FEL as long as the plane or airship has fuel to fly. The light from the FEL will work well with relay mirror systems. The required R&D to achieve the MW level is well understood. The coupling of the capabilities of an airborne FEL to diverse mission requirements provides unique opportunities.« less

Image formation of thick three-dimensional objects in differential-interference-contrast microscopy.

PubMed

Trattner, Sigal; Kashdan, Eugene; Feigin, Micha; Sochen, Nir

2014-05-01

The differential-interference-contrast (DIC) microscope is of widespread use in life sciences as it enables noninvasive visualization of transparent objects. The goal of this work is to model the image formation process of thick three-dimensional objects in DIC microscopy. The model is based on the principles of electromagnetic wave propagation and scattering. It simulates light propagation through the components of the DIC microscope to the image plane using a combined geometrical and physical optics approach and replicates the DIC image of the illuminated object. The model is evaluated by comparing simulated images of three-dimensional spherical objects with the recorded images of polystyrene microspheres. Our computer simulations confirm that the model captures the major DIC image characteristics of the simulated object, and it is sensitive to the defocusing effects.

Development of a two-dimensional zonally averaged statistical-dynamical model. III - The parameterization of the eddy fluxes of heat and moisture

NASA Technical Reports Server (NTRS)

Stone, Peter H.; Yao, Mao-Sung

1990-01-01

A number of perpetual January simulations are carried out with a two-dimensional zonally averaged model employing various parameterizations of the eddy fluxes of heat (potential temperature) and moisture. The parameterizations are evaluated by comparing these results with the eddy fluxes calculated in a parallel simulation using a three-dimensional general circulation model with zonally symmetric forcing. The three-dimensional model's performance in turn is evaluated by comparing its results using realistic (nonsymmetric) boundary conditions with observations. Branscome's parameterization of the meridional eddy flux of heat and Leovy's parameterization of the meridional eddy flux of moisture simulate the seasonal and latitudinal variations of these fluxes reasonably well, while somewhat underestimating their magnitudes. New parameterizations of the vertical eddy fluxes are developed that take into account the enhancement of the eddy mixing slope in a growing baroclinic wave due to condensation, and also the effect of eddy fluctuations in relative humidity. The new parameterizations, when tested in the two-dimensional model, simulate the seasonal, latitudinal, and vertical variations of the vertical eddy fluxes quite well, when compared with the three-dimensional model, and only underestimate the magnitude of the fluxes by 10 to 20 percent.

Reaction-Infiltration Instabilities in Fractured and Porous Rocks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ladd, Anthony

In this project we are developing a multiscale analysis of the evolution of fracture permeability, using numerical simulations and linear stability analysis. Our simulations include fully three-dimensional simulations of the fracture topography, fluid flow, and reactant transport, two-dimensional simulations based on aperture models, and linear stability analysis.

Turbulence in Three Dimensional Simulations of Magnetopause Reconnection

NASA Astrophysics Data System (ADS)

Drake, J. F.; Price, L.; Swisdak, M.; Burch, J. L.; Cassak, P.; Dahlin, J. T.; Ergun, R.

2017-12-01

We present two- and three-dimensional particle-in-cell simulations of the 16 October 2015 MMS magnetopause reconnection event. While the two-dimensional simulation is laminar, turbulence develops at both the x-line and along the magnetic separatrices in the three-dimensional simulation. This turbulence is electromagnetic in nature, is characterized by a wavevector k given by kρ e ˜(m_e/m_i)0.25 with ρ e the electron Larmor radius, and appears to have the ion pressure gradient as its source of free energy. Taken together, these results suggest the instability is a variant of the lower-hybrid drift instability. The turbulence produces electric field fluctuations in the out-of-plane direction (the direction of the reconnection electric field) with an amplitude of around ± 10 mV/m, which is much greater than the reconnection electric field of around 0.1 mV/m. Such large values of the out-of-plane electric field have been identified in the MMS data. The turbulence in the simulation controls the scale lengths of the density profile and current layers in asymmetric reconnection, driving them closer to √ {ρ eρ_i } than the ρ e or de scalings seen in 2D reconnection simulations, where de is the electron inertial length. The turbulence is strong enough to make the magnetic field around the reconnection island chaotic and produces both anomalous resistivity and anomalous viscosity. Each contribute significantly to breaking the frozen-in condition in the electron diffusion region. The crescent-shaped features in velocity space seen both in MMS observations and in two-dimensional simulations survive, even in the turbulent environment of the three-dimensional system. We compare and contrast these results to a three-dimensional simulation of the 8 December 2015 MMS magnetopause reconnection event in which the reconnecting and out-of-plane guide fields are comparable. LHDI is still present in this event, although its appearance is modified by the presence of the guide field. The crescents also survive although, as is also observed by MMS, their intensity decreases. Nevertheless, the turbulence that develops remains strong.

Coherent control schemes for the photoionization of neon and helium in the Extreme Ultraviolet spectral region.

PubMed

Giannessi, Luca; Allaria, Enrico; Prince, Kevin C; Callegari, Carlo; Sansone, Giuseppe; Ueda, Kiyoshi; Morishita, Toru; Liu, Chien Nan; Grum-Grzhimailo, Alexei N; Gryzlova, Elena V; Douguet, Nicolas; Bartschat, Klaus

2018-05-17

The seeded Free-Electron Laser (FEL) FERMI is the first source of short-wavelength light possessing the full coherence of optical lasers, together with the extreme power available from FELs. FERMI provides longitudinally coherent radiation in the Extreme Ultraviolet and soft x-ray spectral regions, and therefore opens up wide new fields of investigation in physics. We first propose experiments exploiting this property to provide coherent control of the photoionization of neon and helium, carry out numerical calculations to find optimum experimental parameters, and then describe how these experiments may be realized. The approach uses bichromatic illumination of a target and measurement of the products of the interaction, analogous to previous Brumer-Shapiro-type experiments in the optical spectral range. We describe operational schemes for the FERMI FEL, and simulate the conditions necessary to produce light at the fundamental and second or third harmonic frequencies, and to control the phase with respect to the fundamental. We conclude that a quantitative description of the phenomena is extremely challenging for present state-of-the-art theoretical and computational methods, and further development is necessary. Furthermore, the intensity available may already be excessive for the experiments proposed on helium. Perspectives for further development are discussed.

The three-dimensional evolution of a plane mixing layer. Part 2: Pairing and transition to turbulence

NASA Technical Reports Server (NTRS)

Moser, Robert D.; Rogers, Michael M.

1992-01-01

The evolution of three-dimensional temporally evolving plane mixing layers through as many as three pairings was simulated numerically. Initial conditions for all simulations consisted of a few low-wavenumber disturbances, usually derived from linear stability theory, in addition to the mean velocity. Three-dimensional perturbations were used with amplitudes ranging from infinitesimal to large enough to trigger a rapid transition to turbulence. Pairing is found both to inhibit the growth of infinitesimal three-dimensional disturbances and to trigger the transition to turbulence in highly three dimensional flows. The mechanisms responsible for the growth of three-dimensionality as well as the initial phases of the transition to turbulence are described. The transition to turbulence is accompanied by the formation of thin sheets of span wise vorticity, which undergo a secondary roll up. Transition also produces an increase in the degree of scalar mixing, in agreement with experimental observations of mixing transition. Simulations were also conducted to investigate changes in span wise length scale that may occur in response to the change in stream wise length scale during a pairing. The linear mechanism for this process was found to be very slow, requiring roughly three pairings to complete a doubling of the span wise scale. Stronger three-dimensionality can produce more rapid scale changes but is also likely to trigger transition to turbulence. No evidence was found for a change from an organized array of rib vortices at one span wise scale to a similar array at a larger span wise scale.

NAPL: SIMULATOR DOCUMENTATION (EPA/600/SR-97/102)

EPA Science Inventory

A mathematical and numerical model is developed to simulate the transport and fate of NAPLs (Non-Aqueous Phase Liquids) in near-surface granular soils. The resulting three-dimensional, three phase simulator is called NAPL. The simulator accommodates three mobile phases: water, NA...

Three-dimensional geomechanical simulation of reservoir compaction and implications for well failures in the Belridge diatomite

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fredrich, J.T.; Argueello, J.G.; Thorne, B.J.

1996-11-01

This paper describes an integrated geomechanics analysis of well casing damage induced by compaction of the diatomite reservoir at the Belridge Field, California. Historical data from the five field operators were compiled and analyzed to determine correlations between production, injection, subsidence, and well failures. The results of this analysis were used to develop a three-dimensional geomechanical model of South Belridge, Section 33 to examine the diatomite reservoir and overburden response to production and injection at the interwell scale and to evaluate potential well failure mechanisms. The time-dependent reservoir pressure field was derived from a three-dimensional finite difference reservoir simulation andmore » used as input to three-dimensional non-linear finite element geomechanical simulations. The reservoir simulation included -200 wells and covered 18 years of production and injection. The geomechanical simulation contained 437,100 nodes and 374,130 elements with the overburden and reservoir discretized into 13 layers with independent material properties. The results reveal the evolution of the subsurface stress and displacement fields with production and injection and suggest strategies for reducing the occurrence of well casing damage.« less

Three-dimensional geomechanical simulation of reservoir compaction and implications for well failures in the Belridge diatomite

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fredrich, J.T.; Argueello, J.G.; Thorne, B.J.

1996-12-31

This paper describes an integrated geomechanics analysis of well casing damage induced by compaction of the diatomite reservoir at the Belridge Field, California. Historical data from the five field operators were compiled and analyzed to determine correlations between production, injection, subsidence, and well failures. The results of this analysis were used to develop a three-dimensional geomechanical model of South Belridge, Section 33 to examine the diatomite reservoir and overburden response to production and injection at the interwell scale and to evaluate potential well failure mechanisms. The time-dependent reservoir pressure field was derived from a three-dimensional finite difference reservoir simulation andmore » used as input to three-dimensional non-linear finite element geomechanical simulations. The reservoir simulation included approximately 200 wells and covered 18 years of production and injection. The geomechanical simulation contained 437,100 nodes and 374,130 elements with the overburden and reservoir discretized into 13 layers with independent material properties. The results reveal the evolution of the subsurface stress and displacement fields with production and injection and suggest strategies for reducing the occurrence of well casing damage.« less

Een Meetsysteem voor het Testen van Radiocommunicatie-Apparatuur (A measuring Facility for Testing of Radio Communication Equipment)

DTIC Science & Technology

1991-08-01

insert various jamming signals. The criterion for classifying radio equipment under test is the quality of transferred information , that is the SINAD...UNCLASSFED) This report describes a test facility for measuring the behaviour and quality of radio communication equipment in a simulated operational...formation FEL has the disposal of a facility to test the quality of radio equipment in a simulated operational situation. (Y .. ,. -’ , / " " ’ TNO mppon 4

A three-dimensional spectral algorithm for simulations of transition and turbulence

NASA Technical Reports Server (NTRS)

Zang, T. A.; Hussaini, M. Y.

1985-01-01

A spectral algorithm for simulating three dimensional, incompressible, parallel shear flows is described. It applies to the channel, to the parallel boundary layer, and to other shear flows with one wall bounded and two periodic directions. Representative applications to the channel and to the heated boundary layer are presented.

An update on molecular cat allergens: Fel d 1 and what else? Chapter 1: Fel d 1, the major cat allergen.

PubMed

Bonnet, B; Messaoudi, K; Jacomet, F; Michaud, E; Fauquert, J L; Caillaud, D; Evrard, B

2018-01-01

Cats are the major source of indoor inhalant allergens after house dust mites. The global incidence of cat allergies is rising sharply, posing a major public health problem. Ten cat allergens have been identified. The major allergen responsible for symptoms is Fel d 1, a secretoglobin and not a lipocalin, making the cat a special case among mammals. Given its clinical predominance, it is essential to have a good knowledge of this allergenic fraction, including its basic structure, to understand the new exciting diagnostic and therapeutic applications currently in development. The recent arrival of the component-resolved diagnosis, which uses molecular allergens, represents a unique opportunity to improve our understanding of the disease. Recombinant Fel d 1 is now available for in vitro diagnosis by the anti-Fel d 1 specific IgE assay. The first part of the review will seek to describe the recent advances related to Fel d 1 in terms of positive diagnosis and assessment of disease severity. In daily practice, anti-Fel d 1 IgE tend to replace those directed against the overall extract but is this attitude justified? We will look at the most recent arguments to try to answer this question. In parallel, a second revolution is taking place thanks to molecular engineering, which has allowed the development of various forms of recombinant Fel d 1 and which seeks to modify the immunomodulatory properties of the molecule and thus the clinical history of the disease via various modalities of anti-Fel d 1-specific immunotherapy. We will endeavor to give a clear and practical overview of all these trends.

Two-gigawatt burst-mode operation of the intense microwave prototype (IMP) free-electron laser (FEL) for the microwave tokamak experiment (MTX)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Felker, B.; Allen, S.; Bell, H.

1993-10-06

The MTX explored the plasma heating effects of 140 GHz microwaves from both Gyrotrons and from the IMP FEL wiggler. The Gyrotron was long pulse length (0.5 seconds maximum) and the FEL produced short-pulse length, high-peak power, single and burst modes of 140 GHZ microwaves. Full-power operations of the IMP FEL wiggler were commenced in April of 1992 and continued into October of 1992. The Experimental Test Accelerator H (ETA-II) provided a 50-nanosecond, 6-MeV, 2--3 kAmp electron beam that was introduced co-linear into the IMP FEL with a 140 GHz Gyrotron master oscillator (MO). The FEL was able to amplifymore » the MO signal from approximately 7 kW to peaks consistently in the range of 1--2 GW. This microwave pulse was transmitted into the MTX and allowed the exploration of the linear and non-linear effects of short pulse, intense power in the MTX plasma. Single pulses were used to explore and gain operating experience in the parameter space of the IMP FEL, and finally evaluate transmission and absorption in the MTX. Single-pulse operations were repeatable. After the MTX was shut down burst-mode operations were successful at 2 kHz. This paper will describe the IMP FEL, Microwave Transmission System to MTX, the diagnostics used for calorimetric measurements, and the operations of the entire Microwave system. A discussion of correlated and uncorrelated errors that affect FEL performance will be made Linear and non-linear absorption data of the microwaves in the MTX plasma will be presented.« less

Unsteady flow simulations around complex geometries using stationary or rotating unstructured grids

NASA Astrophysics Data System (ADS)

Sezer-Uzol, Nilay

In this research, the computational analysis of three-dimensional, unsteady, separated, vortical flows around complex geometries is studied by using stationary or moving unstructured grids. Two main engineering problems are investigated. The first problem is the unsteady simulation of a ship airwake, where helicopter operations become even more challenging, by using stationary unstructured grids. The second problem is the unsteady simulation of wind turbine rotor flow fields by using moving unstructured grids which are rotating with the whole three-dimensional rigid rotor geometry. The three dimensional, unsteady, parallel, unstructured, finite volume flow solver, PUMA2, is used for the computational fluid dynamics (CFD) simulations considered in this research. The code is modified to have a moving grid capability to perform three-dimensional, time-dependent rotor simulations. An instantaneous log-law wall model for Large Eddy Simulations is also implemented in PUMA2 to investigate the very large Reynolds number flow fields of rotating blades. To verify the code modifications, several sample test cases are also considered. In addition, interdisciplinary studies, which are aiming to provide new tools and insights to the aerospace and wind energy scientific communities, are done during this research by focusing on the coupling of ship airwake CFD simulations with the helicopter flight dynamics and control analysis, the coupling of wind turbine rotor CFD simulations with the aeroacoustic analysis, and the analysis of these time-dependent and large-scale CFD simulations with the help of a computational monitoring, steering and visualization tool, POSSE.

Simulation of wave propagation in three-dimensional random media

NASA Astrophysics Data System (ADS)

Coles, Wm. A.; Filice, J. P.; Frehlich, R. G.; Yadlowsky, M.

1995-04-01

Quantitative error analyses for the simulation of wave propagation in three-dimensional random media, when narrow angular scattering is assumed, are presented for plane-wave and spherical-wave geometry. This includes the errors that result from finite grid size, finite simulation dimensions, and the separation of the two-dimensional screens along the propagation direction. Simple error scalings are determined for power-law spectra of the random refractive indices of the media. The effects of a finite inner scale are also considered. The spatial spectra of the intensity errors are calculated and compared with the spatial spectra of

Eigenmode analysis of a high-gain free-electron laser based on a transverse gradient undulator

DOE PAGES

Baxevanis, Panagiotis; Huang, Zhirong; Ruth, Ronald; ...

2015-01-27

Here, the use of a transverse gradient undulator (TGU) is viewed as an attractive option for free-electron lasers (FELs) driven by beams with a large energy spread. By suitably dispersing the electron beam and tilting the undulator poles, the energy spread effect can be substantially mitigated. However, adding the dispersion typically leads to electron beams with large aspect ratios. As a result, the presence of higher-order modes in the FEL radiation can become significant. To investigate this effect, we study the eigenmode properties of a TGU-based, high-gain FEL, using both an analytically-solvable model and a variational technique. Our analysis, whichmore » includes the fundamental and the higher-order FEL eigenmodes, can provide an estimate of the mode content for the output radiation. This formalism also enables us to study the trade-off between FEL gain and transverse coherence. Numerical results are presented for a representative soft X-ray, TGU FEL example.« less

Eigenmode analysis of a high-gain free-electron laser based on a transverse gradient undulator

NASA Astrophysics Data System (ADS)

Baxevanis, Panagiotis; Huang, Zhirong; Ruth, Ronald; Schroeder, Carl B.

2015-01-01

The use of a transverse gradient undulator (TGU) is viewed as an attractive option for free-electron lasers (FELs) driven by beams with a large energy spread. By suitably dispersing the electron beam and tilting the undulator poles, the energy spread effect can be substantially mitigated. However, adding the dispersion typically leads to electron beams with large aspect ratios. As a result, the presence of higher-order modes in the FEL radiation can become significant. To investigate this effect, we study the eigenmode properties of a TGU-based, high-gain FEL, using both an analytically-solvable model and a variational technique. Our analysis, which includes the fundamental and the higher-order FEL eigenmodes, can provide an estimate of the mode content for the output radiation. This formalism also enables us to study the trade-off between FEL gain and transverse coherence. Numerical results are presented for a representative soft X-ray, TGU FEL example.

Face expressive lifting (FEL): an original surgical concept combined with bipolar radiofrequency.

PubMed

Divaris, Marc; Blugerman, Guillermo; Paul, Malcolm D

2014-01-01

Aging can lead to changes in facial expressions, transforming the positive youth expression of happiness to negative expressions as sadness, tiredness, and disgust. Local skin distension is another consequence of aging, which can be difficult to treat with rejuvenation procedures. The "face expressive lifting" (FEL) is an original concept in facial rejuvenation surgery. On the one hand, FEL integrates established convergent surgical techniques aiming to correct the age-related negative facial expressions. On the other hand, FEL incorporates novel bipolar RF technology aiming to correct local skin distension. One hundred twenty-six patients underwent FEL procedure. Facial expression and local skin distension were assessed with 2 years follow-up. There was a correction of negative facial expression for 96 patients (76 %) and a tightening of local skin distension in 100 % of cases. FEL is an effective procedure taking into account and able to correct both age-related negative changes in facial expression and local skin distension using radiofrequency. Level of Evidence: Level IV, therapeutic study.

A plasma source driven predator-prey like mechanism as a potential cause of spiraling intermittencies in linear plasma devices

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reiser, D.; Ohno, N.; Tanaka, H.

2014-03-15

Three-dimensional global drift fluid simulations are carried out to analyze coherent plasma structures appearing in the NAGDIS-II linear device (nagoya divertor plasma Simulator-II). The numerical simulations reproduce several features of the intermittent spiraling structures observed, for instance, statistical properties, rotation frequency, and the frequency of plasma expulsion. The detailed inspection of the three-dimensional plasma dynamics allows to identify the key mechanism behind the formation of these intermittent events. The resistive coupling between electron pressure and parallel electric field in the plasma source region gives rise to a quasilinear predator-prey like dynamics where the axisymmetric mode represents the prey and themore » spiraling structure with low azimuthal mode number represents the predator. This interpretation is confirmed by a reduced one-dimensional quasilinear model derived on the basis of the findings in the full three-dimensional simulations. The dominant dynamics reveals certain similarities to the classical Lotka-Volterra cycle.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allaria, Enrico; Diviacco, Bruno; Callegari, Carlo

The two single-pass, externally seeded free-electron lasers (FELs) of the FERMI user facility are designed around Apple-II-type undulators that can operate at arbitrary polarization in the vacuum ultraviolet-to-soft x-ray spectral range. Furthermore, within each FEL tuning range, any output wavelength and polarization can be set in less than a minute of routine operations. We report the first demonstration of the full output polarization capabilities of FERMI FEL-1 in a campaign of experiments where the wavelength and nominal polarization are set to a series of representative values, and the polarization of the emitted intense pulses is thoroughly characterized by three independentmore » instruments and methods, expressly developed for the task. The measured radiation polarization is consistently >90% and is not significantly spoiled by the transport optics; differing, relative transport losses for horizontal and vertical polarization become more prominent at longer wavelengths and lead to a non-negligible ellipticity for an originally circularly polarized state. The results from the different polarimeter setups validate each other, allow a cross-calibration of the instruments, and constitute a benchmark for user experiments.« less

Emittance growth due to static and radiative space charge forces in an electron bunch compressor

NASA Astrophysics Data System (ADS)

Talman, Richard; Malitsky, Nikolay; Stulle, Frank

2009-01-01

Evolution of short intense electron bunches passing through bunch-compressing beam lines is studied using the UAL (Unified Accelerator Libraries) string space charge formulation [R. Talman, Phys. Rev. ST Accel. Beams 7, 100701 (2004)PRABFM1098-440210.1103/PhysRevSTAB.7.100701; N. Malitsky and R. Talman, in Proceedings of the 9th European Particle Accelerator Conference, Lucerne, 2004 (EPS-AG, Lucerne, 2004); R. Talman, Accelerator X-Ray Sources (Wiley-VCH, Weinheim, 2006), Chap. 13]. Three major configurations are studied, with the first most important and studied in greatest detail (because actual experimental results are available and the same results have been simulated with other codes): (i) Experimental bunch compression results were obtained at CTF-II, the CERN test facility for the “Compact Linear Collider” using electrons of about 40 MeV. Previous simulations of these results have been performed (using TraFiC4* [A. Kabel , Nucl. Instrum. Methods Phys. Res., Sect. A 455, 185 (2000)NIMAER0168-900210.1016/S0168-9002(00)00729-4] and ELEGANT [M. Borland, Argonne National Laboratory Report No. LS-287, 2000]). All three simulations are in fair agreement with the data except that the UAL simulation predicts a substantial dependence of horizontal emittance γx on beam width (as controlled by the lattice βx function) at the compressor location. This is consistent with the experimental observations, but inconsistent with other simulations. Excellent agreement concerning dependence of bunch energy loss on bunch length and magnetic field strength [L. Groening , in Proceedings of the Particle Accelerator Conference, Chicago, IL, 2001 (IEEE, New York, 2001), http://groening.home.cern/groening/csr_00.htm] confirms our understanding of the role played by coherent synchrotron radiation (CSR). (ii) A controlled comparison is made between the predictions of the UAL code and those of CSRTrack [M. Dohlus and T. Limberg, in Proceedings of the 2004 FEL Conference, pp. 18-21, MOCOS05, available at http://www.JACoW.org], a code with similar capabilities. For this comparison an appropriately new, 50 MeV, “standard chicane” is introduced. Unlike CSRTrack (which neglects vertical forces) the present simulation shows substantial growth of vertical emittance. But “turning off” vertical forces in the UAL code (to match the CSRTrack treatment) brings the two codes into excellent agreement. (iii) Results are also obtained for 5 GeV electrons passing through a previously introduced “standard chicane” [Coherent Synchrotron Radiation, CSR Workshop, Berlin 2002, http://www.desy.de/csr] [of the sort needed for linear colliders and free electron lasers (FEL’s) currently under design or construction]. Relatively little emittance growth is predicted for typical bunch parameters at such high electron energy. Results are obtained for both round beams and ribbon beams (like those actually needed in practice). Little or no excess emittance growth is found for ribbon bunches compared to round bunches of the same charge and bunch width. The UAL string space charge formulation (like TraFic4 and CSRTrack) avoids the regularization step (subtracting the free-space space charge force) which is required (to remove divergence) in some methods. Also, by avoiding the need to calculate a retarded-time, four-dimensional field history, the computation time needed for realistic bunch evolution calculations is modest. Some theories of bunch dilution, because they ascribe emittance growth entirely to CSR, break down at low energy. In the present treatment, as well as CSR, all free-space Coulomb and magnetic space charge forces (but not image forces), and also the centrifugal space charge force (CSCF) are included. Charge-dependent beam steering due to CSCF, as observed recently by Beutner et al. [B. Beutner , in Proceedings of FEL Conference, BESSY, Berlin, Germany, 2006, MOPPH009], is also investigated.

Three years of biomedical FEL use in medicine and surgery How far have we come?

NASA Astrophysics Data System (ADS)

Jean, Benedikt

1997-02-01

Since the FEL has been made available for biophysical research in the IR, it has revolutionized the optimization strategies of laser-tissue interaction and the minimizing of adverse effects, in particular for photoablative use in surgery. Its tunability together with the free combination of wavelength and energy made it an efficient research tool, allowing the reduction of risks and costs of preclinical biomedical research. New computer-assisted surgical techniques evolved and the broader data basis of IR photothermal ablation allows more accurate predictive modelling of the efficiency and the adverse effects of photoablation. New applications for diagnostic imaging as well as the first clinical applications in neurosurgery lay ahead.

Integrating the FEL on an All-Electric Ship

DTIC Science & Technology

2007-06-01

6 4. Optical Cavity ( Oscillator Configuration...36 Figure 12. Optical energy in an oscillator FEL with an electron beam tilt. ......................37 Figure 13. Optical energy in an oscillator ...38 Figure 15. Optical energy in an oscillator FEL with a mirror tilt. ....................................39 Figure 16. Diagram of a

Three-dimensional benchmark for variable-density flow and transport simulation: matching semi-analytic stability modes for steady unstable convection in an inclined porous box

USGS Publications Warehouse

Voss, Clifford I.; Simmons, Craig T.; Robinson, Neville I.

2010-01-01

This benchmark for three-dimensional (3D) numerical simulators of variable-density groundwater flow and solute or energy transport consists of matching simulation results with the semi-analytical solution for the transition from one steady-state convective mode to another in a porous box. Previous experimental and analytical studies of natural convective flow in an inclined porous layer have shown that there are a variety of convective modes possible depending on system parameters, geometry and inclination. In particular, there is a well-defined transition from the helicoidal mode consisting of downslope longitudinal rolls superimposed upon an upslope unicellular roll to a mode consisting of purely an upslope unicellular roll. Three-dimensional benchmarks for variable-density simulators are currently (2009) lacking and comparison of simulation results with this transition locus provides an unambiguous means to test the ability of such simulators to represent steady-state unstable 3D variable-density physics.

Cooperative simulation of lithography and topography for three-dimensional high-aspect-ratio etching

NASA Astrophysics Data System (ADS)

Ichikawa, Takashi; Yagisawa, Takashi; Furukawa, Shinichi; Taguchi, Takafumi; Nojima, Shigeki; Murakami, Sadatoshi; Tamaoki, Naoki

2018-06-01

A topography simulation of high-aspect-ratio etching considering transports of ions and neutrals is performed, and the mechanism of reactive ion etching (RIE) residues in three-dimensional corner patterns is revealed. Limited ion flux and CF2 diffusion from the wide space of the corner is found to have an effect on the RIE residues. Cooperative simulation of lithography and topography is used to solve the RIE residue problem.

Convection Effects in Three-dimensional Dendritic Growth

NASA Technical Reports Server (NTRS)

Lu, Yili; Beckermann, C.; Karma, A.

2003-01-01

A phase-field model is developed to simulate free dendritic growth coupled with fluid flow for a pure material in three dimensions. The preliminary results presented here illustrate the strong influence of convection on the three-dimensional (3D) dendrite growth morphology. The detailed knowledge of the flow and temperature fields in the melt around the dendrite from the simulations allows for a detailed understanding of the convection effects on dendritic growth.

Three-Dimensional Simulations of the Convective Urca Process in Pre-Supernova White Dwarfs

NASA Astrophysics Data System (ADS)

Willcox, Donald E.; Townsley, Dean; Zingale, Michael; Calder, Alan

2017-01-01

A significant source of uncertainty in modeling the progenitor systems of Type Ia supernovae is the dynamics of the convective Urca process in which beta decay and electron capture reactions remove energy from and decrease the buoyancy of carbon-fueled convection in the progenitor white dwarf. The details of the Urca process during this simmering phase have long remained computationally intractable in three-dimensional simulations because of the very low convective velocities and the associated timestep constraints of compressible hydrodynamics methods. We report on recent work simulating the A=23 (Ne/Na) Urca process in convecting white dwarfs in three dimensions using the low-Mach hydrodynamics code MAESTRO. We simulate white dwarf models inspired by one-dimensional stellar evolution calculations at the stage when the outer edge of the convection zone driven by core carbon burning reaches the A=23 Urca shell. We compare our methods and results to those of previous work in one and two dimensions, discussing the implications of three dimensional turbulence. We also comment on the prospect of our results informing one-dimensional stellar evolution calculations and the Type Ia supernovae progenitor problem.This work was supported in part by the Department of Energy under grant DE-FG02-87ER40317.

40 CFR 91.118 - Certification procedure-testing.

Code of Federal Regulations, 2014 CFR

2014-07-01

... difference between the old FEL and the new FEL; and that the new FEL applies to all engines covered by the... (CONTINUED) CONTROL OF EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Emission Standards and Certification... test engine using the specified test procedures and appropriate test cycle. All test results must be...

40 CFR 91.118 - Certification procedure-testing.

Code of Federal Regulations, 2012 CFR

2012-07-01

... difference between the old FEL and the new FEL; and that the new FEL applies to all engines covered by the... (CONTINUED) CONTROL OF EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Emission Standards and Certification... test engine using the specified test procedures and appropriate test cycle. All test results must be...

40 CFR 91.118 - Certification procedure-testing.

Code of Federal Regulations, 2011 CFR

2011-07-01

... difference between the old FEL and the new FEL; and that the new FEL applies to all engines covered by the... (CONTINUED) CONTROL OF EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Emission Standards and Certification... test engine using the specified test procedures and appropriate test cycle. All test results must be...

40 CFR 91.118 - Certification procedure-testing.

Code of Federal Regulations, 2010 CFR

2010-07-01

... difference between the old FEL and the new FEL; and that the new FEL applies to all engines covered by the... (CONTINUED) CONTROL OF EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Emission Standards and Certification... test engine using the specified test procedures and appropriate test cycle. All test results must be...

40 CFR 91.118 - Certification procedure-testing.

Code of Federal Regulations, 2013 CFR

2013-07-01

... difference between the old FEL and the new FEL; and that the new FEL applies to all engines covered by the... (CONTINUED) CONTROL OF EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Emission Standards and Certification... test engine using the specified test procedures and appropriate test cycle. All test results must be...

Free energy landscape theory of glass transition

NASA Astrophysics Data System (ADS)

Odagaki, Takashi

2010-03-01

I first present a free energy landscape (FEL) description of statistical mechanics, which is an exact reformulation of statistical mechanics and can be applied to non-equilibrium systems. Then, I discuss thermodynamic and dynamic properties of the vitrification process on the basis of the FEL formalism. I show that thermodynamic and dynamic anomalies at the glass transition, including the cooling rate dependence, can be understood in a unified manner which has not been achieved by any other theories of the glass transition. Namely, I show that the vitrification is a transition from annealed to quenched averages in the FEL and that the fast beta, the JG and the slow alpha relaxations are attributed to stochastic dynamics within a basin of FEL, jumping motion among locally connected basins and diffusive dynamics over barriers of the FEL.

Free electron laser and fundamental physics

NASA Astrophysics Data System (ADS)

Dattoli, Giuseppe; Nguyen, Federico

2018-03-01

This review paper is devoted to the understanding of free-electron lasers (FEL) as devices for fundamental physics (FP) studies. After clarifying what FP stands for, we select some aspects of the FEL physics which can be viewed as fundamental. Furthermore, we discuss the perspective uses of the FEL in FP experiments. Regarding the FP aspects of the FEL, we analyze the quantum electrodynamics (QED) nature of the underlying laser mechanism. We look for the truly quantum signature in a process whose phenomenology is dominated by classical effects. As to the use of FEL as a tool for FP experiments we discuss the realization of a device dedicated to the study of non-linear effects in QED such as photon-photon scattering and shining-through-the-wall experiments planned to search for dark matter candidates like axions.

Enhancement of Permeation in Transdermal Drug Delivery System by 6μm Wavelength Area Using an MIR-FEL

NASA Astrophysics Data System (ADS)

Uchizono, T.; Ishii, K.; Iwao, Y.; Itou, Y.; Maruo, H.; Hori, M.; Awazu, K.

2005-03-01

Ablation of the stratum corneum (SC) by pulsed-laser irradiation is one method of enhancing transdermal drug delivery (TD). For non-invasive laser TD treatment, we have tried to enhance TD without ablation of the SC using an MIR-FEL (6-μm wavelength) (FEL : free electron laser). Lidocaine was used as the drug in this study. The enhancement of TD was measured by HPLC. It was found that the lidocaine TD of the sample irradiated by MIR-FEL was enhanced 10 fold faster than the non-irradiated sample with a flux at 0.5 μg/cm2/h, measured by HPLC. We have demonstrated the effectiveness of TD enhancement by an MIR-FEL (6-μm wavelength) irradiation.

Acute optic nerve sheath fenestration in humans using the free electron laser (FEL): a case report

NASA Astrophysics Data System (ADS)

Joos, Karen M.; Mawn, Louise A.; Shen, Jin-Hui; Jansen, E. Duco; Casagrande, Vivien A.

2002-06-01

Our previous studies using rabbits and monkeys showed that the Amide II wavelength (6.45 micrometers ) produced by the FEL could efficiently produce an optic nerve sheath fenestration with minimal damage. In order to determine if the technology safely could be applied to human surgery, we used 2 blind human eyes during enucleation to compare the results of producing fenestrations with the FEL or a scissors. FDA and Vanderbilt IRB approvals, and individual patient consents were obtained. The FEL energy was transmitted to a human operating room. After disinsertion of the medial rectus muscle, an optic nerve sheath fenestration (2 mm diameter) was made with either the FEL (6.45 micrometers , 325 micrometers spot size, 30 Hz, 3 mJ) through a hollow waveguide surgical probe or with a scissors. The enucleation was then completed. The optic nerve was dissected from the globe and fixed. Specimens were examined histologically. Dural incisions were effective with both methods. FEL energy at 6.45 micrometers can be transmitted to an operating room and delivered to human ocular tissue through a hollow waveguide surgical probe. This FEL wavelength can produce an optic nerve sheath fenestration without acute direct damage to the nerve in this case report.

Direct numerical simulation of steady state, three dimensional, laminar flow around a wall mounted cube

NASA Astrophysics Data System (ADS)

Liakos, Anastasios; Malamataris, Nikolaos A.

2014-05-01

The topology and evolution of flow around a surface mounted cubical object in three dimensional channel flow is examined for low to moderate Reynolds numbers. Direct numerical simulations were performed via a home made parallel finite element code. The computational domain has been designed according to actual laboratory experiment conditions. Analysis of the results is performed using the three dimensional theory of separation. Our findings indicate that a tornado-like vortex by the side of the cube is present for all Reynolds numbers for which flow was simulated. A horseshoe vortex upstream from the cube was formed at Reynolds number approximately 1266. Pressure distributions are shown along with three dimensional images of the tornado-like vortex and the horseshoe vortex at selected Reynolds numbers. Finally, and in accordance to previous work, our results indicate that the upper limit for the Reynolds number for which steady state results are physically realizable is roughly 2000.

Crystallographic data processing for free-electron laser sources

DOE Office of Scientific and Technical Information (OSTI.GOV)

White, Thomas A., E-mail: taw@physics.org; Barty, Anton; Stellato, Francesco

2013-07-01

A processing pipeline for diffraction data acquired using the ‘serial crystallography’ methodology with a free-electron laser source is described with reference to the crystallographic analysis suite CrystFEL and the pre-processing program Cheetah. A processing pipeline for diffraction data acquired using the ‘serial crystallography’ methodology with a free-electron laser source is described with reference to the crystallographic analysis suite CrystFEL and the pre-processing program Cheetah. A detailed analysis of the nature and impact of indexing ambiguities is presented. Simulations of the Monte Carlo integration scheme, which accounts for the partially recorded nature of the diffraction intensities, are presented and show thatmore » the integration of partial reflections could be made to converge more quickly if the bandwidth of the X-rays were to be increased by a small amount or if a slight convergence angle were introduced into the incident beam.« less

Longitudinal space charge assisted echo seeding of a free-electron laser with laser-spoiler noise suppression

NASA Astrophysics Data System (ADS)

Hacker, Kirsten

2014-09-01

Seed lasers are employed to improve the temporal coherence of free-electron laser (FEL) light. However, when these seed pulses are short relative to the particle bunch, the noisy, temporally incoherent radiation from the unseeded electrons can overwhelm the coherent, seeded radiation. In this paper, a technique to seed a particle bunch with an external laser is presented in which a new mechanism to improve the contrast between coherent and incoherent free electron laser radiation is employed together with a novel, simplified echo-seeding method. The concept relies on a combination of longitudinal space charge wakes and an echo-seeding technique to make a short, coherent pulse of FEL light together with noise background suppression. Several different simulation codes are used to illustrate the concept with conditions at the soft x-ray free-electron laser in Hamburg, FLASH.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flechsig, U.; Follath, R.; Reiche, S.

PHASE is a software tool for physical optics simulation based on the stationary phase approximation method. The code is under continuous development since about 20 years and has been used for instance for fundamental studies and ray tracing of various beamlines at the Swiss Light Source. Along with the planning for SwissFEL a new hard X-ray free electron laser under construction, new features have been added to permit practical performance predictions including diffraction effects which emerge with the fully coherent source. We present the application of the package on the example of the ARAMIS 1 beamline at SwissFEL. The X-raymore » pulse calculated with GENESIS and given as an electrical field distribution has been propagated through the beamline to the sample position. We demonstrate the new features of PHASE like the treatment of measured figure errors, apertures and coatings of the mirrors and the application of Fourier optics propagators for free space propagation.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wolski, A.; Penn, G.; Sessler, A.

The consequences of beam conditioning in four example cases [VISA, a soft x-ray free-electron laser (FEL), LCLS, and a 'Greenfield' FEL] are examined. It is shown that in emittance limited cases, proper conditioning reduces sensitivity to the transverse emittance and, furthermore, allows for stronger focusing in the undulator. Simulations show higher saturation power, with gain lengths reduced by a factor of 2 or more. The beam dynamics in a general conditioning system are studied, with 'matching conditions' derived for achieving conditioning without growth in the effective emittance. Various conditioning lattices are considered, and expressions derived for the amount of conditioningmore » provided in each case when the matching conditions are satisfied. These results show that there is no fundamental obstacle to producing beam conditioning, and that the problem can be reduced to one of proper lattice design. Nevertheless, beam conditioning will not be easy to implement in practice.« less

Design and test of SX-FEL cavity BPM

NASA Astrophysics Data System (ADS)

Yuan, Ren-Xian; Zhou, Wei-Min; Chen, Zhi-Chu; Yu, Lu-Yang; Wang, Bao-Pen; Leng, Yong-Bin

2013-11-01

This paper reports the design and cold test of the cavity beam position monitor (CBPM) for SX-FEL to fulfill the requirement of beam position measurement resolution of less than 1 μm, even 0.1 μm. The CBPM was optimized by using a coupling slot to damp the TM010 mode in the output signal. The isolation of TM010 mode is about 117 dB, and the shunt impedance is about 200 Ω@4.65 GHz with the quality factor 80 from MAFIA simulation and test result. A special antenna was designed to load power for reducing excitation of other modes in the cavity. The resulting output power of TM110 mode was about 90 mV/mm when the source was 6 dBm, and the accomplishable minimum voltage was about 200 μV. The resolution of the CBPM was about 0.1 μm from the linear fitting result based on the cold test.

An adaptive front tracking technique for three-dimensional transient flows

NASA Astrophysics Data System (ADS)

Galaktionov, O. S.; Anderson, P. D.; Peters, G. W. M.; van de Vosse, F. N.

2000-01-01

An adaptive technique, based on both surface stretching and surface curvature analysis for tracking strongly deforming fluid volumes in three-dimensional flows is presented. The efficiency and accuracy of the technique are demonstrated for two- and three-dimensional flow simulations. For the two-dimensional test example, the results are compared with results obtained using a different tracking approach based on the advection of a passive scalar. Although for both techniques roughly the same structures are found, the resolution for the front tracking technique is much higher. In the three-dimensional test example, a spherical blob is tracked in a chaotic mixing flow. For this problem, the accuracy of the adaptive tracking is demonstrated by the volume conservation for the advected blob. Adaptive front tracking is suitable for simulation of the initial stages of fluid mixing, where the interfacial area can grow exponentially with time. The efficiency of the algorithm significantly benefits from parallelization of the code. Copyright

Simulations of dusty plasmas using a special-purpose computer system designed for gravitational N-body problems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yamamoto, K.; Mizuno, Y.; Hibino, S.

2006-01-15

Simulations of dusty plasmas were performed using GRAPE-6, a special-purpose computer designed for gravitational N-body problems. The collective behavior of dust particles, which are injected into the plasma, was studied by means of three-dimensional computer simulations. As an example of a dusty plasma simulation, experiments on Coulomb crystals in plasmas are simulated. Formation of a quasi-two-dimensional Coulomb crystal has been observed under typical laboratory conditions. Another example was to simulate movement of dust particles in plasmas under microgravity conditions. Fully three-dimensional spherical structures of dust clouds have been observed. For the simulation of a dusty plasma in microgravity with 3x10{supmore » 4} particles, GRAPE-6 can perform the whole operation 1000 times faster than by using a Pentium 4 1.6 GHz processor.« less

Three-dimensional simulation of the free shear layer using the vortex-in-cell method

NASA Technical Reports Server (NTRS)

Couet, B.; Buneman, O.; Leonard, A.

1979-01-01

We present numerical simulations of the evolution of a mixing layer from an initial state of uniform vorticity with simple two- and three-dimensional small perturbations. A new method for tracing a large number of three-dimensional vortex filaments is used in the simulations. Vortex tracing by Biot-Savart interaction originally implied ideal (non-viscous) flow, but we use a 3-d mesh, Fourier transforms and filtering for vortex tracing, which implies 'modeling' of subgrid scale motion and hence some viscosity. Streamwise perturbations lead to the usual roll-up of vortex patterns with spanwise uniformity maintained. Remarkably, spanwise perturbations generate streamwise distortions of the vortex filaments and the combination of both perturbations leads to patterns with interesting features discernable in the movies and in the records of enstrophy and energy for the three components of the flow.

Cat allergen levels in public places in New Zealand.

PubMed

Martin, I R; Wickens, K; Patchett, K; Kent, R; Fitzharris, P; Siebers, R; Lewis, S; Crane, J; Holbrook, N; Town, G I; Smith, S

1998-09-25

Cat allergen (Fel d 1) is a known risk factor for asthma. Studies have demonstrated Fel d 1 in both public buildings and domestic dwellings where cats have never been. The aims of this study were to measure reservoir Fel d 1 levels in public buildings in New Zealand, to examine determinants of these levels and to compare them with previously measured domestic levels. Dust was obtained in two centres (Wellington and Christchurch) from hotels, hospitals, rest homes, churches, primary schools, childcare centres, cinemas, bank head offices and aeroplanes; and from North Island ski lodges. Measurements of temperature and relative humidity were taken. Information was collected on building characteristics. Fel d 1 levels (microg/g of fine dust) for floors (n=203), beds (n=64) and seats (n=24) were expressed as geometric means (95% confidence intervals). Detectable Fel d 1 levels were found in 95% of floor samples, 91% of bed samples and 100% of seat samples. Fel d 1 levels [geometric mean (95% confidence intervals)] were significantly higher on cinema and domestic aircraft seats [36.8 (20.8-65.3) microg/g and 33.3 (28.0-39.7) microg/g respectively] than on floors [3.6 (2.5-5.1) microg/g and 2.4 (1.8-3.0) microg/g respectively]. Floor Fel d 1 levels in the public buildings sampled were lower than those of domestic dwellings without cats [0.9 (0.6-1.4) microg/g vs 1.7 (1.2-2.4)] microg/g in Wellington and [2.0 (1.6-2.6) microg/g vs 4.0 (2.7-6.0] microg/g in Christchurch. After controlling for potential confounders, floor Fel d 1 levels were higher with carpeted floors (p<0.001) and lower in banks and hospitals (p<0.001). Fel d 1 levels in public buildings are low in New Zealand public places except for cinema and domestic aircraft seats where all but one sample had Fel d 1 levels potentially high enough to precipitate asthma symptoms in sensitised individuals.

The trapped-particle instability in the Boeing 1kW FEL oscillator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ramos, L.; Blau, J.; Colson, W.B.

1995-12-31

The new design for the Boeing High Average Power Free Electron Laser will operate at 1KW average power (0.63 {mu}m) with a peak current of 132A. Simulations are used to investigate the trapped-particle instability and diffraction effects. Incorporating large desynchronism may prove to be a useful method of controlling the trapped-particle instability.

Studies Of Coherent Synchrotron Radiation And Longitudinal Space Charge In The Jefferson Lab FEL Driver

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tennant, Christopher D.; Douglas, David R.; Li, Rui

2014-12-01

The Jefferson Laboratory IR FEL Driver provides an ideal test bed for studying a variety of beam dynamical effects. Recent studies focused on characterizing the impact of coherent synchrotron radiation (CSR) with the goal of benchmarking measurements with simulation. Following measurements to characterize the beam, we quantitatively characterized energy extraction via CSR by measuring beam position at a dispersed location as a function of bunch compression. In addition to operating with the beam on the rising part of the linac RF waveform, measurements were also made while accelerating on the falling part. For each, the full compression point was movedmore » along the backleg of the machine and the response of the beam (distribution, extracted energy) measured. Initial results of start-to-end simulations using a 1D CSR algorithm show remarkably good agreement with measurements. A subsequent experiment established lasing with the beam accelerated on the falling side of the RF waveform in conjunction with positive momentum compaction (R56) to compress the bunch. The success of this experiment motivated the design of a modified CEBAF-style arc with control of CSR and microbunching effects.« less

Modeling of induction-linac based free-electron laser amplifiers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jong, R.A.; Fawley, W.M.; Scharlemann, E.T.

We describe the modeling of an induction-linac based free-electron laser (IFEL) amplifier for producing multimegawatt levels of microwave power. We have used the Lawrence Livermore National Laboratory (LLNL) free-electron laser simulation code, FRED, and the simulation code for sideband calculations, GINGER for this study. For IFEL amplifiers in the frequency range of interest (200 to 600 GHz), we have devised a wiggler design strategy which incorporates a tapering algorithm that is suitable for free-electron laser (FEL) systems with moderate space-charge effects and that minimizes spontaneous noise growth at frequencies below the fundamental, while enhancing the growth of the signal atmore » the fundamental. In addition, engineering design considerations of the waveguide wall loading and electron beam fill factor in the waveguide set limits on the waveguide dimensions, the wiggler magnet gap spacing, the wiggler period, and the minimum magnetic field strength in the tapered region of the wiggler. As an example, we shall describe an FEL amplifier designed to produce an average power of about 10 MW at a frequency of 280 GHz to be used for electron cyclotron resonance heating of tokamak fusion devices. 17 refs., 4 figs.« less

The PixFEL project: Progress towards a fine pitch X-ray imaging camera for next generation FEL facilities

NASA Astrophysics Data System (ADS)

Rizzo, G.; Batignani, G.; Benkechkache, M. A.; Bettarini, S.; Casarosa, G.; Comotti, D.; Dalla Betta, G.-F.; Fabris, L.; Forti, F.; Grassi, M.; Lodola, L.; Malcovati, P.; Manghisoni, M.; Mendicino, R.; Morsani, F.; Paladino, A.; Pancheri, L.; Paoloni, E.; Ratti, L.; Re, V.; Traversi, G.; Vacchi, C.; Verzellesi, G.; Xu, H.

2016-07-01

The INFN PixFEL project is developing the fundamental building blocks for a large area X-ray imaging camera to be deployed at next generation free electron laser (FEL) facilities with unprecedented intensity. Improvement in performance beyond the state of art in imaging instrumentation will be explored adopting advanced technologies like active edge sensors, a 65 nm node CMOS process and vertical integration. These are the key ingredients of the PixFEL project to realize a seamless large area focal plane instrument composed by a matrix of multilayer four-side buttable tiles. In order to minimize the dead area and reduce ambiguities in image reconstruction, a fine pitch active edge thick sensor is being optimized to cope with very high intensity photon flux, up to 104 photons per pixel, in the range from 1 to 10 keV. A low noise analog front-end channel with this wide dynamic range and a novel dynamic compression feature, together with a low power 10 bit analog to digital conversion up to 5 MHz, has been realized in a 110 μm pitch with a 65 nm CMOS process. Vertical interconnection of two CMOS tiers will be also explored in the future to build a four-side buttable readout chip with high density memories. In the long run the objective of the PixFEL project is to build a flexible X-ray imaging camera for operation both in burst mode, like at the European X-FEL, or in continuous mode with the high frame rates anticipated for future FEL facilities.

Validity and reliability of the Fels physical activity questionnaire for children.

PubMed

Treuth, Margarita S; Hou, Ningqi; Young, Deborah R; Maynard, L Michele

2005-03-01

The aim was to evaluate the reliability and validity of the Fels physical activity questionnaire (PAQ) for children 7-19 yr of age. A cross-sectional study was conducted among 130 girls and 99 boys in elementary (N=70), middle (N=81), and high (N=78) schools in rural Maryland. Weight and height were measured on the initial school visit. All the children then wore an Actiwatch accelerometer for 6 d. The Fels PAQ for children was given on two separate occasions to evaluate reliability and was compared with accelerometry data to evaluate validity. The reliability of the Fels PAQ for the girls, boys, and the elementary, middle, and high school age groups range was r=0.48-0.76. For the elementary school children, the correlation coefficient examining validity between the Fels PAQ total score and Actiwatch (counts per minute) was 0.34 (P=0.004). The correlation coefficients were lower in middle school (r=0.11, P=0.31) and high school (r=0.21, P=0.006) adolescents. The sport index of the Fels PAQ for children had the highest validity in the high school participants (r=0.34, P=0.002). The Fels PAQ for children is moderately reliable for all age groups of children. Validity of the Fels PAQ for children is acceptable for elementary and high school students when the total activity score or the sport index is used. The sport index was similar to the total score for elementary students but was a better measure of physical activity among high school students.

A comparative study of progressive wear of four dental monolithic, veneered glass-ceramics.

PubMed

Zhang, Zhenzhen; Yi, Yuanping; Wang, Xuesong; Guo, Jiawen; Li, Ding; He, Lin; Zhang, Shaofeng

2017-10-01

This study evaluated the wear performance and wear mechanisms of four dental glass-ceramics, based on the microstructure and mechanical properties in the progressive wear process. Bar (N = 40, n = 10) and disk (N = 32, n = 8) specimens were prepared from (A) lithium disilicate glass-ceramic (LD), (B) leucite reinforced glass-ceramic (LEU), (C) feldspathic glass-ceramic (FEL), and (D) fluorapatite glass-ceramic (FLU). The bar specimens were tested for three-point flexural strength, hardness, fracture toughness and elastic modulus. The disk specimens paired with steatite antagonists were tested in a pin-on-disk tribometer with 10N up to 1000,000 wear cycles. The wear analysis of glass-ceramics was performed using a 3D profilometer after every 200,000 wear cycles. Wear loss of steatite antagonists was calculated by measuring the weight and density using sensitive balance and Archimedes' method. Wear morphologies and microstructures were analyzed by scanning electron microscopy (SEM). The crystalline phase compositions were determined using X-ray diffraction (XRD). One-way analysis of variance (ANOVA) was used to analyze the data. Multiple pair-wise comparison of means was performed by Tukey's post-hoc test. LD showed the highest fracture toughness, flexural strength, elastic modulus and crystallinity, followed by LEU and FEL, and FLU showed the lowest. However, the hardness of LD was lower than all the other three types of ceramics. For steatite antagonists, LD produced the least wear loss of antagonist, followed by LEU and FEL, and FLU had the most wear loss. For glass-ceramic materials, LD exhibited similar wear loss as LEU, but more than FLU and FEL did. Moreover, fracture occurred on the wear surface of FLU. In the progressive wear process, veneering porcelains showed better wear resistance but fluorapatite veneering porcelains appeared fracture surface. Monolithic lithium disilicate glass-ceramics with higher mechanical properties showed more wear loss, however, they did not fracture and produced less wear loss of antagonists. Copyright © 2017 Elsevier Ltd. All rights reserved.

40 CFR 1051.730 - What ABT reports must I send to EPA?

Code of Federal Regulations, 2014 CFR

2014-07-01

..., identify the date that you started using the new FEL and/or give the vehicle identification number for the first vehicle covered by the new FEL. In this case, identify each applicable FEL and calculate the... POLLUTION CONTROLS CONTROL OF EMISSIONS FROM RECREATIONAL ENGINES AND VEHICLES Averaging, Banking, and...

40 CFR 1051.730 - What ABT reports must I send to EPA?

Code of Federal Regulations, 2011 CFR

2011-07-01

..., identify the date that you started using the new FEL and/or give the vehicle identification number for the first vehicle covered by the new FEL. In this case, identify each applicable FEL and calculate the... POLLUTION CONTROLS CONTROL OF EMISSIONS FROM RECREATIONAL ENGINES AND VEHICLES Averaging, Banking, and...

77 FR 75660 - Agency Information Collection Activities; Proposed Collection; Comments Requested: FEL Out-of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-21

...] Agency Information Collection Activities; Proposed Collection; Comments Requested: FEL Out-of-Business.... (2) Title of the Form/Collection: FEL Out of Business Records. (3) Form Number: None. Bureau of..., as well as a brief abstract: Primary: Business or other for-profit. Other: None. Need for Collection...

Development of an alternative testing strategy for the fish early life-stage (FELS) test using the AOP framework

EPA Science Inventory

Currently, the fish early life-stage (FELS) test (OECD 210) is the primary guideline used to estimate chronic toxicity of regulated chemicals. Although already more cost-efficient than adult fish tests, the FELS test has some important drawbacks. Both industry and regulatory inst...

A scheme for a shot-to-shot, femtosecond-resolved pulse length and arrival time measurement of free electron laser x-ray pulses that overcomes the time jitter problem between the FEL and the laser

NASA Astrophysics Data System (ADS)

Juranić, P. N.; Stepanov, A.; Peier, P.; Hauri, C. P.; Ischebeck, R.; Schlott, V.; Radović, M.; Erny, C.; Ardana-Lamas, F.; Monoszlai, B.; Gorgisyan, I.; Patthey, L.; Abela, R.

2014-03-01

The recent entry of X-ray free electron lasers (FELs) to all fields of physics has created an enormous need, both from scientists and operators, for better characterization of the beam created by these facilities. Of particular interest is the measurement of the arrival time of the FEL pulse relative to a laser pump, for pump-probe experiments, and the measurement of the FEL pulse length. This article describes a scheme that corrects one of the major sources of uncertainty in these types of measurements, namely the jitter in the arrival time of the FEL relative to an experimental laser beam. The setup presented here uses a combination of THz streak cameras and a spectral encoding setup to reduce the effect of an FEL's jitter, leaving the pulse length as the only variable that can affect the accuracy of the pulse length and arrival time measurement. A discussion of underlying principles is also provided.

Hemostatic properties of the free-electron laser

NASA Astrophysics Data System (ADS)

Cram, Gary P., Jr.; Copeland, Michael L.

1998-09-01

We have investigated the hemostatic properties of the free-electron laser (FEL) and compared these properties to the most commonly used commercial lasers in neurosurgery, CO 2 and Nd:YAG, using an acute canine model. Arterial and venous vessels, of varying diameters from 0.1 to 1.0 mm, were divided with all three lasers. Analysis of five wavelengths of the FEL (3.0, 4.5, 6.1, 6.45, and 7.7 microns) resulted in bleeding without evidence of significant coagulation, regardless of whether the vessel was an artery or vein. Hemorrhage from vessels less than 0.4 mm diameter was subsequently easily controlled with Gelfoam® (topical hemostatic agent) alone, whereas larger vessels required bipolar electrocautery. No significant charring, or contraction of the surrounding parenchyma was noted with any of the wavelengths chosen from FEL source. The CO 2 laser, in continuous mode, easily coagulated vessels with diameters of 4 mm and less, while larger vessels displayed significant bleeding requiring bipolar electrocautery for control. Tissue charring was noted with application of the CO 2 laser. In super pulse mode, the CO 2 laser exhibited similar properties, including significant charring of the surrounding parenchyma. The Nd:YAG coagulated all vessels tested up to 1.4 mm, which was the largest diameter cortical artery found, however this laser displayed significant and extensive contraction and retraction of the surrounding parenchyma. In conclusion, the FEL appears to be a poor hemostatic agent. Our results did not show any benefit of the FEL over current conventional means of achieving hemostasis. However, control of hemorrhage was easily achieved with currently used methods of hemostasis, namely Gelfoam® or bipolar electrocuatery. Although only cortical vessels in dogs were tested, we feel this data can be applied to all animals, including humans, and the peripheral, as well as central, vasculature, as our data on the CO 2 and Nd:YAG appear to closely support previous reports of hemostasis of these two lasers obtained in other models.

Three-Dimensional Temperature Field Simulation for the Rotor of an Asynchronous Motor

ERIC Educational Resources Information Center

Wang, Yanwu; Fan, Chunli; Yang, Li; Sun, Fengrui

2010-01-01

A three-dimensional heat transfer model is built according to the rotor structure of an asynchronous motor, and three-dimensional temperature fields of the rotor under different working conditions, such as the unloaded, rated loaded and that with broken rotor bars, are studied based on the finite element numerical method and experiments. The…

The three-dimensional Event-Driven Graphics Environment (3D-EDGE)

NASA Technical Reports Server (NTRS)

Freedman, Jeffrey; Hahn, Roger; Schwartz, David M.

1993-01-01

Stanford Telecom developed the Three-Dimensional Event-Driven Graphics Environment (3D-EDGE) for NASA GSFC's (GSFC) Communications Link Analysis and Simulation System (CLASS). 3D-EDGE consists of a library of object-oriented subroutines which allow engineers with little or no computer graphics experience to programmatically manipulate, render, animate, and access complex three-dimensional objects.

Simulation of wave propagation in three-dimensional random media

NASA Technical Reports Server (NTRS)

Coles, William A.; Filice, J. P.; Frehlich, R. G.; Yadlowsky, M.

1993-01-01

Quantitative error analysis for simulation of wave propagation in three dimensional random media assuming narrow angular scattering are presented for the plane wave and spherical wave geometry. This includes the errors resulting from finite grid size, finite simulation dimensions, and the separation of the two-dimensional screens along the propagation direction. Simple error scalings are determined for power-law spectra of the random refractive index of the media. The effects of a finite inner scale are also considered. The spatial spectra of the intensity errors are calculated and compared to the spatial spectra of intensity. The numerical requirements for a simulation of given accuracy are determined for realizations of the field. The numerical requirements for accurate estimation of higher moments of the field are less stringent.

Milk protein composition and stability changes affected by iron in water sources.

PubMed

Wang, Aili; Duncan, Susan E; Knowlton, Katharine F; Ray, William K; Dietrich, Andrea M

2016-06-01

Water makes up more than 80% of the total weight of milk. However, the influence of water chemistry on the milk proteome has not been extensively studied. The objective was to evaluate interaction of water-sourced iron (low, medium, and high levels) on milk proteome and implications on milk oxidative state and mineral content. Protein composition, oxidative stability, and mineral composition of milk were investigated under conditions of iron ingestion through bovine drinking water (infused) as well as direct iron addition to commercial milk in 2 studies. Four ruminally cannulated cows each received aqueous infusions (based on water consumption of 100L) of 0, 2, 5, and 12.5mg/L Fe(2+) as ferrous lactate, resulting in doses of 0, 200, 500 or 1,250mg of Fe/d, in a 4×4Latin square design for a 14-d period. For comparison, ferrous sulfate solution was directly added into commercial retail milk at the same concentrations: control (0mg of Fe/L), low (2mg of Fe/L), medium (5mg of Fe/L), and high (12.5mg of Fe/L). Two-dimensional electrophoresis coupled with matrix-assisted laser desorption/ionization-tandem time-of-flight (MALDI-TOF/TOF) high-resolution tandem mass spectrometry analysis was applied to characterize milk protein composition. Oxidative stability of milk was evaluated by the thiobarbituric acid reactive substances (TBARS) assay for malondialdehyde, and mineral content was measured by inductively coupled plasma mass spectrometry. For milk from both abomasal infusion of ferrous lactate and direct addition of ferrous sulfate, an iron concentration as low as 2mg of Fe/L was able to cause oxidative stress in dairy cattle and infused milk, respectively. Abomasal infusion affected both caseins and whey proteins in the milk, whereas direct addition mainly influenced caseins. Although abomasal iron infusion did not significantly affect oxidation state and mineral balance (except iron), it induced oxidized off-flavor and partial degradation of whey proteins. Direct iron addition to milk led to lipid oxidation during storage at 4°C. Oxidation level was positively associated with the concentration of added iron. Minerals (Mg, P, Na, K, Ca, Zn) in milk were not affected by the added iron in milk. This study indicated that a small amount of iron contamination in bovine drinking water at the farm or incidental iron addition from potable water sources causes oxidation, affects milk protein composition and stability, and affects final milk quality. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Optimization for Single-Spike X-Ray FELs at LCLS with a Low Charge Beam

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, L.; Ding, Y.; Huang, Z.

2011-12-14

The Linac Coherent Light Source is an x-ray free-electron laser at the SLAC National Accelerator Laboratory, which is operating at x-ray wavelengths of 20-1.2 Angstrom with peak brightness nearly ten orders of magnitude beyond conventional synchrotron radiation sources. At the low charge operation mode (20 pC), the x-ray pulse length can be <10 fs. In this paper we report our numerical optimization and simulations to produce even shorter x-ray pulses by optimizing the machine and undulator setup at 20 pC charge. In the soft x-ray regime, with combination of slotted-foil or undulator taper, a single spike x-ray pulse is achievablemore » with peak FEL power of a few 10s GW. Linac Coherent Light Source (LCLS), the world's first hard x-ray Free electron laser (FEL), has started operation since 2009. With nominal operation charge of 250 pC, the generated x-ray pulse length is from 70 fs to a few hundred fs. This marks the beginning of a new era of ultrashort x-ray sciences. In addition, a low charge (20pC) operation mode has also been established. Since the collective effects are reduced at the low charge mode, we can increase the compression factor and still achieve a few kA peak current. The expected electron beam and x-ray pulses are less than 10 fs. There are growing interests in even shorter x-ray pulses, such as fs to sub-fs regime. One of the simple solutions is going to even lower charge. As discussed, single-spike x-ray pulses can be generated using 1 pC charge. However, this charge level is out of the present LCLS diagnostic range. 20 pC is a reasonable operation charge at LCLS, based on the present diagnostic system. At 20 pC in the soft x-ray wavelength regime, we have experimentally demonstrated that FEL can work at undercompression or over-compression mode, such as 1 degree off the full-compression; at full-compression, however, there is almost no lasing. In hard x-ray wavelength regime, we observed that there are reasonable photons generated even at full-compression mode, although the photon number is less than that from under-compression or over-compression mode. Since we cannot measure the x-ray pulse length at this time scale, the machine is typically optimized for generating maximum photons, not minimum pulse length. In this paper, we study the methods of producing femtosecond (or single-spike) x-ray pulses at LCLS with 20 pC charge, based on start-to-end simulations. Figure 1 shows a layout of LCLS. The compression in the second bunch compressor (BC2) determines the final e-beam bunch length. However, the laser heater, dog-leg after the main linac (DL2) and collective effects also affect the final bunch length. To adjust BC2 compression, we can either change the L2 phase or BC2 R{sub 56}. In this paper we only tune L2 phase while keep BC2 R{sub 56} fixed. For the start-to-end simulations, we used IMPACT-T and ELEGANT tracking from the photocathode to the entrance of the undulator, after that the FEL radiation was simulated with GENESIS. IMPACT-T tracks about 10{sup 6} particles in the injector part until 135 MeV, including 3D space charge force. The output particles from IMPACT-T are smoothed and increased to 12 x 10{sup 6} to reduce high-frequency numerical noise for subsequent ELEGANT simulations, which include linear and nonlinear transport effects, a 1D transient model of CSR, and longitudinal space charge effects, as well as geometric and resistive wake fields in the accelerator. In GENESIS part, the longitudinal wake field from undulator chamber and longitudinal space field are also included.« less

High-Fidelity Real-Time Simulation on Deployed Platforms

DTIC Science & Technology

2010-08-26

three–dimensional transient heat conduction “ Swiss Cheese ” problem; and a three–dimensional unsteady incompressible Navier- Stokes low–Reynolds–number...our approach with three examples: a two?dimensional Helmholtz acoustics ?horn? problem; a three?dimensional transient heat conduction ? Swiss Cheese ...solutions; a transient lin- ear heat conduction problem in a three–dimensional “ Swiss Cheese ” configuration Ω — to illustrate treat- ment of many

Two-dimensional numerical simulation of flow around three-stranded rope

NASA Astrophysics Data System (ADS)

Wang, Xinxin; Wan, Rong; Huang, Liuyi; Zhao, Fenfang; Sun, Peng

2016-08-01

Three-stranded rope is widely used in fishing gear and mooring system. Results of numerical simulation are presented for flow around a three-stranded rope in uniform flow. The simulation was carried out to study the hydrodynamic characteristics of pressure and velocity fields of steady incompressible laminar and turbulent wakes behind a three-stranded rope. A three-cylinder configuration and single circular cylinder configuration are used to model the three-stranded rope in the two-dimensional simulation. The governing equations, Navier-Stokes equations, are solved by using two-dimensional finite volume method. The turbulence flow is simulated using Standard κ-ɛ model and Shear-Stress Transport κ-ω (SST) model. The drag of the three-cylinder model and single cylinder model is calculated for different Reynolds numbers by using control volume analysis method. The pressure coefficient is also calculated for the turbulent model and laminar model based on the control surface method. From the comparison of the drag coefficient and the pressure of the single cylinder and three-cylinder models, it is found that the drag coefficients of the three-cylinder model are generally 1.3-1.5 times those of the single circular cylinder for different Reynolds numbers. Comparing the numerical results with water tank test data, the results of the three-cylinder model are closer to the experiment results than the single cylinder model results.

Numerical aerodynamic simulation facility. [for flows about three-dimensional configurations

NASA Technical Reports Server (NTRS)

Bailey, F. R.; Hathaway, A. W.

1978-01-01

Critical to the advancement of computational aerodynamics capability is the ability to simulate flows about three-dimensional configurations that contain both compressible and viscous effects, including turbulence and flow separation at high Reynolds numbers. Analyses were conducted of two solution techniques for solving the Reynolds averaged Navier-Stokes equations describing the mean motion of a turbulent flow with certain terms involving the transport of turbulent momentum and energy modeled by auxiliary equations. The first solution technique is an implicit approximate factorization finite-difference scheme applied to three-dimensional flows that avoids the restrictive stability conditions when small grid spacing is used. The approximate factorization reduces the solution process to a sequence of three one-dimensional problems with easily inverted matrices. The second technique is a hybrid explicit/implicit finite-difference scheme which is also factored and applied to three-dimensional flows. Both methods are applicable to problems with highly distorted grids and a variety of boundary conditions and turbulence models.

Influence of nonlinear effects on statistical properties of the radiation from SASE FEL

NASA Astrophysics Data System (ADS)

Saldin, E. L.; Schneidmiller, E. A.; Yurkov, M. V.

1998-02-01

The paper presents analysis of statistical properties of the radiation from self-amplified spontaneous emission (SASE) free-electron laser operating in nonlinear mode. The present approach allows one to calculate the following statistical properties of the SASE FEL radiation: time and spectral field correlation functions, distribution of the fluctuations of the instantaneous radiation power, distribution of the energy in the electron bunch, distribution of the radiation energy after monochromator installed at the FEL amplifier exit and the radiation spectrum. It has been observed that the statistics of the instantaneous radiation power from SASE FEL operating in the nonlinear regime changes significantly with respect to the linear regime. All numerical results presented in the paper have been calculated for the 70 nm SASE FEL at the TESLA Test Facility under construction at DESY.

Comparing the Impact of Dynamic and Static Media on Students' Learning of One-Dimensional Kinematics

ERIC Educational Resources Information Center

Mešic, Vanes; Dervic, Dževdeta; Gazibegovic-Busuladžic, Azra; Salibašic, Džana; Erceg, Nataša

2015-01-01

In our study, we aimed to compare the impact of simulations, sequences of printed simulation frames and conventional static diagrams on the understanding of students with regard to the one-dimensional kinematics. Our student sample consisted of three classes of middle years students (N = 63; mostly 15 year-olds). These three classes served as…

Fused rock from Köfels, Tyrol

USGS Publications Warehouse

Milton, Daniel J.

1964-01-01

The vesicular glass from Köfels, Tyrol, contains grains of quartz that have been partially melted but not dissolved in the matrix glass. This phenomenon has been observed in similar glasses formed by friction along a thrust fault and by meteorite impact, but not in volcanic glasses. The explosion of a small nuclear device buried behind a steep slope produced a geologic structure that is a good small-scale model of that at Köfels. Impact of a large meteorite would have an effect analogous to that of a subsurface nuclear explosion and is the probable cause of the Köfels feature.

3D DNS and LES of Breaking Inertia-Gravity Waves

NASA Astrophysics Data System (ADS)

Remmler, S.; Fruman, M. D.; Hickel, S.; Achatz, U.

2012-04-01

As inertia-gravity waves we refer to gravity waves that have a sufficiently low frequency and correspondingly large horizontal wavelength to be strongly influenced by the Coriolis force. Inertia-gravity waves are very active in the middle atmosphere and their breaking is potentially an important influence on the circulation in this region. The parametrization of this process requires a good theoretical understanding, which we want to enhance with the present study. Primary linear instabilities of an inertia-gravity wave and "2.5-dimensional" nonlinear simulations (where the spatial dependence is two dimensional but the velocity and vorticity fields are three-dimensional) with the wave perturbed by its leading primary instabilities by Achatz [1] have shown that the breaking differs significantly from that of high-frequency gravity waves due to the strongly sheared component of velocity perpendicular to the plane of wave-propagation. Fruman & Achatz [2] investigated the three-dimensionalization of the breaking by computing the secondary linear instabilities of the same waves using singular vector analysis. These secondary instabilities are variations perpendicular to the direction of the primary perturbation and the wave itself, and their wavelengths are an order of magnitude shorter than both. In continuation of this work, we carried out fully three-dimensional nonlinear simulations of inertia-gravity waves perturbed by their leading primary and secondary instabilities. The direct numerical simulation (DNS) was made tractable by restricting the domain size to the dominant scales selected by the linear analyses. The study includes both convectively stable and unstable waves. To the best of our knowledge, this is the first fully three-dimensional nonlinear direct numerical simulation of inertia-gravity waves at realistic Reynolds numbers with complete resolution of the smallest turbulence scales. Previous simulations either were restricted to high frequency gravity waves (e. g. Fritts et al. [3]), or the ratio N/f was artificially reduced (e. g. Lelong & Dunkerton [4]). The present simulations give us insight into the three-dimensional breaking process as well as the emerging turbulence. We assess the possibility of reducing the computational costs of three-dimensional simulations by using an implicit turbulence subgrid-scale parametrization based on the Adaptive Local Deconvolution Method (ALDM) for stratified turbulence [5]. In addition, we have performed ensembles of nonlinear 2.5-dimensional DNS, like those in Achatz [1] but with a small amount of noise superposed to the initial state, and compared the results with coarse-resolution simulations using either ALDM as well as with standard LES schemes. We found that the results of the models with parametrized turbulence, which are orders of magnitude more computationally economical than the DNS, compare favorably with the DNS in terms of the decay of the wave amplitude with time (the quantity most important for application to gravity-wave drag parametrization) suggesting that they may be trusted in future simulations of gravity wave breaking.

Striation pattern of target particle and heat fluxes in three dimensional simulations for DIII-D [On the striation pattern of target particle and heat fluxes in three dimensional simulations for DIII-D

DOE PAGES

Frerichs, H.; Schmitz, Oliver; Reiter, D.; ...

2014-02-04

The application of resonant magnetic perturbations (RMPs) results in a non-axisymmetric striation pattern of magnetic field lines from the plasma interior which intersect the divertor targets. The impact on related particle and heat fluxes is investigated by three dimensional computer simulations for two different recycling conditions (controlled via neutral gas pumping). It is demonstrated that a mismatch between the particle and heat flux striation pattern, as is repeatedly observed in ITER similar shape H-mode plasmas at DIII-D, can be reproduced by the simulations for high recycling conditions at the onset of partial detachment. Finally, these results indicate that a detailedmore » knowledge of the particle and energy balance is at least as important for realistic simulations as the consideration of a change in the magnetic field structure by plasma response effects.« less

The investigation of tethered satellite system dynamics

NASA Technical Reports Server (NTRS)

Lorenzini, E.

1985-01-01

A progress report is presented that deals with three major topics related to Tethered Satellite System Dynamics. The SAO rotational dynamics computer code was updated. The program is now suitable to deal with inclined orbits. The output has been also modified in order to show the satellite Euler angles referred to the rotating orbital frame. The three-dimensional high resolution computer program SLACK3 was developed. The code simulates the three-dimensional dynamics of a tether going slack taking into account the effect produced by boom rotations. Preliminary simulations on the three-dimensional dynamics of a recoiling slack tether are shown in this report. A program to evaluate the electric potential around a severed tether is immersed in a plasma. The potential is computed on a three-dimensional grid axially symmetric with respect to the tether longitudinal axis. The electric potential variations due to the plasma are presently under investigation.

Conditioning of BPM pickup signals for operations of the Duke storage ring with a wide range of single-bunch current

NASA Astrophysics Data System (ADS)

Xu, Wei; Li, Jing-Yi; Huang, Sen-Lin; Z. Wu, W.; Hao, H.; P., Wang; K. Wu, Y.

2014-10-01

The Duke storage ring is a dedicated driver for the storage ring based oscillator free-electron lasers (FELs), and the High Intensity Gamma-ray Source (HIGS). It is operated with a beam current ranging from about 1 mA to 100 mA per bunch for various operations and accelerator physics studies. High performance operations of the FEL and γ-ray source require a stable electron beam orbit, which has been realized by the global orbit feedback system. As a critical part of the orbit feedback system, the electron beam position monitors (BPMs) are required to be able to precisely measure the electron beam orbit in a wide range of the single-bunch current. However, the high peak voltage of the BPM pickups associated with high single-bunch current degrades the performance of the BPM electronics, and can potentially damage the BPM electronics. A signal conditioning method using low pass filters is developed to reduce the peak voltage to protect the BPM electronics, and to make the BPMs capable of working with a wide range of single-bunch current. Simulations and electron beam based tests are performed. The results show that the Duke storage ring BPM system is capable of providing precise orbit measurements to ensure highly stable FEL and HIGS operations.

Simulation of confined magnetohydrodynamic flows with Dirichlet boundary conditions using a pseudo-spectral method with volume penalization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Morales, Jorge A.; Leroy, Matthieu; Bos, Wouter J.T.

A volume penalization approach to simulate magnetohydrodynamic (MHD) flows in confined domains is presented. Here the incompressible visco-resistive MHD equations are solved using parallel pseudo-spectral solvers in Cartesian geometries. The volume penalization technique is an immersed boundary method which is characterized by a high flexibility for the geometry of the considered flow. In the present case, it allows to use other than periodic boundary conditions in a Fourier pseudo-spectral approach. The numerical method is validated and its convergence is assessed for two- and three-dimensional hydrodynamic (HD) and MHD flows, by comparing the numerical results with results from literature and analyticalmore » solutions. The test cases considered are two-dimensional Taylor–Couette flow, the z-pinch configuration, three dimensional Orszag–Tang flow, Ohmic-decay in a periodic cylinder, three-dimensional Taylor–Couette flow with and without axial magnetic field and three-dimensional Hartmann-instabilities in a cylinder with an imposed helical magnetic field. Finally, we present a magnetohydrodynamic flow simulation in toroidal geometry with non-symmetric cross section and imposing a helical magnetic field to illustrate the potential of the method.« less

40 CFR 1036.625 - In-use compliance with family emission limits (FELs).

Code of Federal Regulations, 2014 CFR

2014-07-01

... (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW AND IN-USE HEAVY-DUTY HIGHWAY ENGINES... us to apply a higher in-use FEL for certain in-use engines, subject to the provisions of this section... higher in-use FELs to your engines, we would intend to accurately reflect the actual in-use performance...

40 CFR 1036.625 - In-use compliance with family emission limits (FELs).

Code of Federal Regulations, 2012 CFR

2012-07-01

... (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW AND IN-USE HEAVY-DUTY HIGHWAY ENGINES... us to apply a higher in-use FEL for certain in-use engines, subject to the provisions of this section... higher in-use FELs to your engines, we would intend to accurately reflect the actual in-use performance...

40 CFR 1036.625 - In-use compliance with family emission limits (FELs).

Code of Federal Regulations, 2013 CFR

2013-07-01

... (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW AND IN-USE HEAVY-DUTY HIGHWAY ENGINES... us to apply a higher in-use FEL for certain in-use engines, subject to the provisions of this section... higher in-use FELs to your engines, we would intend to accurately reflect the actual in-use performance...

Numerical simulation of three-dimensional transonic turbulent projectile aerodynamics by TVD schemes

NASA Technical Reports Server (NTRS)

Shiau, Nae-Haur; Hsu, Chen-Chi; Chyu, Wei-Jao

1989-01-01

The two-dimensional symmetric TVD scheme proposed by Yee has been extended to and investigated for three-dimensional thin-layer Navier-Stokes simulation of complex aerodynamic problems. An existing three-dimensional Navier-stokes code based on the beam and warming algorithm is modified to provide an option of using the TVD algorithm and the flow problem considered is a transonic turbulent flow past a projectile with sting at ten-degree angle of attack. Numerical experiments conducted for three flow cases, free-stream Mach numbers of 0.91, 0.96 and 1.20 show that the symmetric TVD algorithm can provide surface pressure distribution in excellent agreement with measured data; moreover, the rate of convergence to attain a steady state solution is about two times faster than the original beam and warming algorithm.

3DHYDROGEOCHEM: A 3-DIMENSIONAL MODEL OF DENSITY-DEPENDENT SUBSURFACE FLOW AND THERMAL MULTISPECIES-MULTICOMPONENT HYDROGEOCHEMICAL TRANSPORT

EPA Science Inventory

This report presents a three-dimensional finite-element numerical model designed to simulate chemical transport in subsurface systems with temperature effect taken into account. The three-dimensional model is developed to provide (1) a tool of application, with which one is able...

A three-dimensional dual potential procedure with applications to wind tunnel inlets and interacting boundary layers

NASA Technical Reports Server (NTRS)

Rao, K. V.; Pletcher, R. H.; Steger, J. L.; Vandalsem, W. R.

1987-01-01

A dual potential decomposition of the velocity field into a scalar and a vector potential function is extended to three dimensions and used in the finite-difference simulation of steady three-dimensional inviscid rotational flows and viscous flow. The finite-difference procedure was used to simulate the flow through the 80 by 120 ft wind tunnel at NASA Ames Research Center. Rotational flow produced by the stagnation pressure drop across vanes and screens which are located at the entrance of the inlet is modeled using actuator disk theory. Results are presented for two different inlet vane and screen configurations. The numerical predictions are in good agreement with experimental data. The dual potential procedure was also applied to calculate the viscous flow along two and three dimensional troughs. Viscous effects are simulated by injecting vorticity which is computed from a boundary layer algorithm. For attached flow over a three dimensional trough, the present calculations are in good agreement with other numerical predictions. For separated flow, it is shown from a two dimensional analysis that the boundary layer approximation provides an accurate measure of the vorticity in regions close to the wall; whereas further away from the wall, caution has to be exercised in using the boundary-layer equations to supply vorticity to the dual potential formulation.

Nonlinear optics with coherent free electron lasers

NASA Astrophysics Data System (ADS)

Bencivenga, F.; Capotondi, F.; Mincigrucci, R.; Cucini, R.; Manfredda, M.; Pedersoli, E.; Principi, E.; Simoncig, A.; Masciovecchio, C.

2016-12-01

We interpreted the recent construction of free electron laser (FELs) facilities worldwide as an unprecedented opportunity to bring concepts and methods from the scientific community working with optical lasers into the domain of x-ray science. This motivated our efforts towards the realization of FEL-based wave-mixing applications. In this article we present new extreme ultraviolet transient grating (X-TG) data from vitreous SiO2, collected using two crossed FEL pulses (photon frequency 38 eV) to generate the X-TG and a phase matched optical probing pulse (photon frequency 3.1 eV). This experiment extends our previous investigation, which was carried out on a nominally identical sample using a different FEL photon frequency (45 eV) to excite the X-TG. The present data are featured by a peak intensity of the X-TG signal substantially larger than that previously reported and by slower modulations of the X-TG signal at positive delays. These differences could be ascribed to the different FEL photon energy used in the two experiments or to differences in the sample properties. A systematic X-TG study on the same sample as a function of the FEL wavelength is needed to draw a consistent conclusion. We also discuss how the advances in the performance of the FELs, in terms of generation of fully coherent photon pulses and multi-color FEL emission, may push the development of original experimental strategies to study matter at the femtosecond-nanometer time-length scales, with the unique option of element and chemical state specificity. This would allow the development of advanced experimental tools based on wave-mixing processes, which may have a tremendous impact in the study of a large array of phenomena, ranging from nano-dynamics in complex materials to charge and energy transfer processes.

Transient simulation of hydropower station with consideration of three-dimensional unsteady flow in turbine

NASA Astrophysics Data System (ADS)

Huang, W. D.; Fan, H. G.; Chen, N. X.

2012-11-01

To study the interaction between the transient flow in pipe and the unsteady turbulent flow in turbine, a coupled model of the transient flow in the pipe and three-dimensional unsteady flow in the turbine is developed based on the method of characteristics and the fluid governing equation in the accelerated rotational relative coordinate. The load-rejection process under the closing of guide vanes of the hydraulic power plant is simulated by the coupled method, the traditional transient simulation method and traditional three-dimensional unsteady flow calculation method respectively and the results are compared. The pressure, unit flux and rotation speed calculated by three methods show a similar change trend. However, because the elastic water hammer in the pipe and the pressure fluctuation in the turbine have been considered in the coupled method, the increase of pressure at spiral inlet is higher and the pressure fluctuation in turbine is stronger.

One-Dimensional Collision Carts Computer Model and Its Design Ideas for Productive Experiential Learning

ERIC Educational Resources Information Center

Wee, Loo Kang

2012-01-01

We develop an Easy Java Simulation (EJS) model for students to experience the physics of idealized one-dimensional collision carts. The physics model is described and simulated by both continuous dynamics and discrete transition during collision. In designing the simulations, we discuss briefly three pedagogical considerations namely (1) a…

Evaluation of three-dimensional virtual perception of garments

NASA Astrophysics Data System (ADS)

Aydoğdu, G.; Yeşilpinar, S.; Erdem, D.

2017-10-01

In recent years, three-dimensional design, dressing and simulation programs came into prominence in the textile industry. By these programs, the need to produce clothing samples for every design in design process has been eliminated. Clothing fit, design, pattern, fabric and accessory details and fabric drape features can be evaluated easily. Also, body size of virtual mannequin can be adjusted so more realistic simulations can be created. Moreover, three-dimensional virtual garment images created by these programs can be used while presenting the product to end-user instead of two-dimensional photograph images. In this study, a survey was carried out to investigate the visual perception of consumers. The survey was conducted for three different garment types, separately. Questions about gender, profession etc. was asked to the participants and expected them to compare real samples and artworks or three-dimensional virtual images of garments. When survey results were analyzed statistically, it is seen that demographic situation of participants does not affect visual perception and three-dimensional virtual garment images reflect the real sample characteristics better than artworks for each garment type. Also, it is reported that there is no perception difference depending on garment type between t-shirt, sweatshirt and tracksuit bottom.

Genetic evolution of bacteriophage. I. Hybrids between unrelated bacteriophages P22 and Fels 2.

PubMed

Yamamoto, N

1969-01-01

A new bacteriophage species, designated F22, was isolated from phage P22 stocks grown on Salmonella typhimurium Q1 lysogenic for Fels 2 at a frequency of less than 10(-11). P22 has a very short tail with a hexagonal base plate and six spikes. Phage Fels 2 is morphologically similar to E. coli T-even phages, having a long tail with a contractile sheath and carrying no genetic region related to P22. Phage F22 is morphologically and serologically indistinguishable from Fels 2, but carries the c(c(1), c(2), and c(3)) markers of P22. The color markers h(21), g, and m(3) of P22 do not appear in F22. Thus, F22 is evidently a recombinant between the unrelated bacteriophages P22 and Fels 2. The recombination between unrelated bacteriophages could play an important role in the evolution of bacteriophages.

Quantum theory for 1D X-ray free electron laser

DOE PAGES

Anisimov, Petr Mikhaylovich

2017-09-19

Classical 1D X-ray Free Electron Laser (X-ray FEL) theory has stood the test of time by guiding FEL design and development prior to any full-scale analysis. Future X-ray FELs and inverse-Compton sources, where photon recoil approaches an electron energy spread value, push the classical theory to its limits of applicability. After substantial efforts by the community to find what those limits are, there is no universally agreed upon quantum approach to design and development of future X-ray sources. We offer a new approach to formulate the quantum theory for 1D X-ray FELs that has an obvious connection to the classicalmore » theory, which allows for immediate transfer of knowledge between the two regimes. In conclusion, we exploit this connection in order to draw quantum mechanical conclusions about the quantum nature of electrons and generated radiation in terms of FEL variables.« less

Quantum theory for 1D X-ray free electron laser

NASA Astrophysics Data System (ADS)

Anisimov, Petr M.

2018-06-01

Classical 1D X-ray Free Electron Laser (X-ray FEL) theory has stood the test of time by guiding FEL design and development prior to any full-scale analysis. Future X-ray FELs and inverse-Compton sources, where photon recoil approaches an electron energy spread value, push the classical theory to its limits of applicability. After substantial efforts by the community to find what those limits are, there is no universally agreed upon quantum approach to design and development of future X-ray sources. We offer a new approach to formulate the quantum theory for 1D X-ray FELs that has an obvious connection to the classical theory, which allows for immediate transfer of knowledge between the two regimes. We exploit this connection in order to draw quantum mechanical conclusions about the quantum nature of electrons and generated radiation in terms of FEL variables.

Single-shot spectro-temporal characterization of XUV pulses from a seeded free-electron laser

PubMed Central

De Ninno, Giovanni; Gauthier, David; Mahieu, Benoît; Ribič, Primož Rebernik; Allaria, Enrico; Cinquegrana, Paolo; Danailov, Miltcho Bojanov; Demidovich, Alexander; Ferrari, Eugenio; Giannessi, Luca; Penco, Giuseppe; Sigalotti, Paolo; Stupar, Matija

2015-01-01

Intense ultrashort X-ray pulses produced by modern free-electron lasers (FELs) allow one to probe biological systems, inorganic materials and molecular reaction dynamics with nanoscale spatial and femtoscale temporal resolution. These experiments require the knowledge, and possibly the control, of the spectro-temporal content of individual pulses. FELs relying on seeding have the potential to produce spatially and temporally fully coherent pulses. Here we propose and implement an interferometric method, which allows us to carry out the first complete single-shot spectro-temporal characterization of the pulses, generated by an FEL in the extreme ultraviolet spectral range. Moreover, we provide the first direct evidence of the temporal coherence of a seeded FEL working in the extreme ultraviolet spectral range and show the way to control the light generation process to produce Fourier-limited pulses. Experiments are carried out at the FERMI FEL in Trieste. PMID:26290320

FLASH free-electron laser single-shot temporal diagnostic: terahertz-field-driven streaking.

PubMed

Ivanov, Rosen; Liu, Jia; Brenner, Günter; Brachmanski, Maciej; Düsterer, Stefan

2018-01-01

The commissioning of a terahertz-field-driven streak camera installed at the free-electron laser (FEL) FLASH at DESY in Hamburg, being able to deliver photon pulse duration as well as arrival time information with ∼10 fs resolution for each single XUV FEL pulse, is reported. Pulse durations between 300 fs and <15 fs have been measured for different FLASH FEL settings. A comparison between the XUV pulse arrival time and the FEL electron bunch arrival time measured at the FLASH linac section exhibits a correlation width of 20 fs r.m.s., thus demonstrating the excellent operation stability of FLASH. In addition, the terahertz-streaking setup was operated simultaneously to an alternative method to determine the FEL pulse duration based on spectral analysis. FLASH pulse duration derived from simple spectral analysis is in good agreement with that from terahertz-streaking measurement.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anisimov, Petr Mikhaylovich

Classical 1D X-ray Free Electron Laser (X-ray FEL) theory has stood the test of time by guiding FEL design and development prior to any full-scale analysis. Future X-ray FELs and inverse-Compton sources, where photon recoil approaches an electron energy spread value, push the classical theory to its limits of applicability. After substantial efforts by the community to find what those limits are, there is no universally agreed upon quantum approach to design and development of future X-ray sources. We offer a new approach to formulate the quantum theory for 1D X-ray FELs that has an obvious connection to the classicalmore » theory, which allows for immediate transfer of knowledge between the two regimes. In conclusion, we exploit this connection in order to draw quantum mechanical conclusions about the quantum nature of electrons and generated radiation in terms of FEL variables.« less

Full-Scale Direct Numerical Simulation of Two- and Three-Dimensional Instabilities and Rivulet Formulation in Heated Falling Films

NASA Technical Reports Server (NTRS)

Krishnamoorthy, S.; Ramaswamy, B.; Joo, S. W.

1995-01-01

A thin film draining on an inclined plate has been studied numerically using finite element method. Three-dimensional governing equations of continuity, momentum and energy with a moving boundary are integrated in an arbitrary Lagrangian Eulerian frame of reference. Kinematic equation is solved to precisely update interface location. Rivulet formation based on instability mechanism has been simulated using full-scale computation. Comparisons with long-wave theory are made to validate the numerical scheme. Detailed analysis of two- and three-dimensional nonlinear wave formation and spontaneous rupture forming rivulets under the influence of combined thermocapillary and surface-wave instabilities is performed.

Three-dimensional scene reconstruction from a two-dimensional image

NASA Astrophysics Data System (ADS)

Parkins, Franz; Jacobs, Eddie

2017-05-01

We propose and simulate a method of reconstructing a three-dimensional scene from a two-dimensional image for developing and augmenting world models for autonomous navigation. This is an extension of the Perspective-n-Point (PnP) method which uses a sampling of the 3D scene, 2D image point parings, and Random Sampling Consensus (RANSAC) to infer the pose of the object and produce a 3D mesh of the original scene. Using object recognition and segmentation, we simulate the implementation on a scene of 3D objects with an eye to implementation on embeddable hardware. The final solution will be deployed on the NVIDIA Tegra platform.

Updates to Multi-Dimensional Flux Reconstruction for Hypersonic Simulations on Tetrahedral Grids

NASA Technical Reports Server (NTRS)

Gnoffo, Peter A.

2010-01-01

The quality of simulated hypersonic stagnation region heating with tetrahedral meshes is investigated by using an updated three-dimensional, upwind reconstruction algorithm for the inviscid flux vector. An earlier implementation of this algorithm provided improved symmetry characteristics on tetrahedral grids compared to conventional reconstruction methods. The original formulation however displayed quantitative differences in heating and shear that were as large as 25% compared to a benchmark, structured-grid solution. The primary cause of this discrepancy is found to be an inherent inconsistency in the formulation of the flux limiter. The inconsistency is removed by employing a Green-Gauss formulation of primitive gradients at nodes to replace the previous Gram-Schmidt algorithm. Current results are now in good agreement with benchmark solutions for two challenge problems: (1) hypersonic flow over a three-dimensional cylindrical section with special attention to the uniformity of the solution in the spanwise direction and (2) hypersonic flow over a three-dimensional sphere. The tetrahedral cells used in the simulation are derived from a structured grid where cell faces are bisected across the diagonal resulting in a consistent pattern of diagonals running in a biased direction across the otherwise symmetric domain. This grid is known to accentuate problems in both shock capturing and stagnation region heating encountered with conventional, quasi-one-dimensional inviscid flux reconstruction algorithms. Therefore the test problems provide a sensitive indicator for algorithmic effects on heating. Additional simulations on a sharp, double cone and the shuttle orbiter are then presented to demonstrate the capabilities of the new algorithm on more geometrically complex flows with tetrahedral grids. These results provide the first indication that pure tetrahedral elements utilizing the updated, three-dimensional, upwind reconstruction algorithm may be used for the simulation of heating and shear in hypersonic flows in upwind, finite volume formulations.

Decipher the mechanisms of protein conformational changes induced by nucleotide binding through free-energy landscape analysis: ATP binding to Hsp70.

PubMed

Nicolaï, Adrien; Delarue, Patrice; Senet, Patrick

2013-01-01

ATP regulates the function of many proteins in the cell by transducing its binding and hydrolysis energies into protein conformational changes by mechanisms which are challenging to identify at the atomic scale. Based on molecular dynamics (MD) simulations, a method is proposed to analyze the structural changes induced by ATP binding to a protein by computing the effective free-energy landscape (FEL) of a subset of its coordinates along its amino-acid sequence. The method is applied to characterize the mechanism by which the binding of ATP to the nucleotide-binding domain (NBD) of Hsp70 propagates a signal to its substrate-binding domain (SBD). Unbiased MD simulations were performed for Hsp70-DnaK chaperone in nucleotide-free, ADP-bound and ATP-bound states. The simulations revealed that the SBD does not interact with the NBD for DnaK in its nucleotide-free and ADP-bound states whereas the docking of the SBD was found in the ATP-bound state. The docked state induced by ATP binding found in MD is an intermediate state between the initial nucleotide-free and final ATP-bound states of Hsp70. The analysis of the FEL projected along the amino-acid sequence permitted to identify a subset of 27 protein internal coordinates corresponding to a network of 91 key residues involved in the conformational change induced by ATP binding. Among the 91 residues, 26 are identified for the first time, whereas the others were shown relevant for the allosteric communication of Hsp70 s in several experiments and bioinformatics analysis. The FEL analysis revealed also the origin of the ATP-induced structural modifications of the SBD recently measured by Electron Paramagnetic Resonance. The pathway between the nucleotide-free and the intermediate state of DnaK was extracted by applying principal component analysis to the subset of internal coordinates describing the transition. The methodology proposed is general and could be applied to analyze allosteric communication in other proteins.

Decipher the Mechanisms of Protein Conformational Changes Induced by Nucleotide Binding through Free-Energy Landscape Analysis: ATP Binding to Hsp70

PubMed Central

Nicolaï, Adrien; Delarue, Patrice; Senet, Patrick

2013-01-01

ATP regulates the function of many proteins in the cell by transducing its binding and hydrolysis energies into protein conformational changes by mechanisms which are challenging to identify at the atomic scale. Based on molecular dynamics (MD) simulations, a method is proposed to analyze the structural changes induced by ATP binding to a protein by computing the effective free-energy landscape (FEL) of a subset of its coordinates along its amino-acid sequence. The method is applied to characterize the mechanism by which the binding of ATP to the nucleotide-binding domain (NBD) of Hsp70 propagates a signal to its substrate-binding domain (SBD). Unbiased MD simulations were performed for Hsp70-DnaK chaperone in nucleotide-free, ADP-bound and ATP-bound states. The simulations revealed that the SBD does not interact with the NBD for DnaK in its nucleotide-free and ADP-bound states whereas the docking of the SBD was found in the ATP-bound state. The docked state induced by ATP binding found in MD is an intermediate state between the initial nucleotide-free and final ATP-bound states of Hsp70. The analysis of the FEL projected along the amino-acid sequence permitted to identify a subset of 27 protein internal coordinates corresponding to a network of 91 key residues involved in the conformational change induced by ATP binding. Among the 91 residues, 26 are identified for the first time, whereas the others were shown relevant for the allosteric communication of Hsp70 s in several experiments and bioinformatics analysis. The FEL analysis revealed also the origin of the ATP-induced structural modifications of the SBD recently measured by Electron Paramagnetic Resonance. The pathway between the nucleotide-free and the intermediate state of DnaK was extracted by applying principal component analysis to the subset of internal coordinates describing the transition. The methodology proposed is general and could be applied to analyze allosteric communication in other proteins. PMID:24348227

Control of the polarization of a vacuum-ultraviolet, high-gain, free-electron laser

DOE PAGES

Allaria, Enrico; Diviacco, Bruno; Callegari, Carlo; ...

2014-12-02

The two single-pass, externally seeded free-electron lasers (FELs) of the FERMI user facility are designed around Apple-II-type undulators that can operate at arbitrary polarization in the vacuum ultraviolet-to-soft x-ray spectral range. Furthermore, within each FEL tuning range, any output wavelength and polarization can be set in less than a minute of routine operations. We report the first demonstration of the full output polarization capabilities of FERMI FEL-1 in a campaign of experiments where the wavelength and nominal polarization are set to a series of representative values, and the polarization of the emitted intense pulses is thoroughly characterized by three independentmore » instruments and methods, expressly developed for the task. The measured radiation polarization is consistently >90% and is not significantly spoiled by the transport optics; differing, relative transport losses for horizontal and vertical polarization become more prominent at longer wavelengths and lead to a non-negligible ellipticity for an originally circularly polarized state. The results from the different polarimeter setups validate each other, allow a cross-calibration of the instruments, and constitute a benchmark for user experiments.« less

Perspective: Opportunities for ultrafast science at SwissFEL

PubMed Central

Abela, Rafael; Beaud, Paul; van Bokhoven, Jeroen A.; Chergui, Majed; Feurer, Thomas; Haase, Johannes; Ingold, Gerhard; Johnson, Steven L.; Knopp, Gregor; Lemke, Henrik; Milne, Chris J.; Pedrini, Bill; Radi, Peter; Schertler, Gebhard; Standfuss, Jörg; Staub, Urs; Patthey, Luc

2018-01-01

We present the main specifications of the newly constructed Swiss Free Electron Laser, SwissFEL, and explore its potential impact on ultrafast science. In light of recent achievements at current X-ray free electron lasers, we discuss the potential territory for new scientific breakthroughs offered by SwissFEL in Chemistry, Biology, and Materials Science, as well as nonlinear X-ray science. PMID:29376109

A contrastive study on the influences of radial and three-dimensional satellite gravity gradiometry on the accuracy of the Earth's gravitational field recovery

NASA Astrophysics Data System (ADS)

Zheng, Wei; Hsu, Hou-Tse; Zhong, Min; Yun, Mei-Juan

2012-10-01

The accuracy of the Earth's gravitational field measured from the gravity field and steady-state ocean circulation explorer (GOCE), up to 250 degrees, influenced by the radial gravity gradient Vzz and three-dimensional gravity gradient Vij from the satellite gravity gradiometry (SGG) are contrastively demonstrated based on the analytical error model and numerical simulation, respectively. Firstly, the new analytical error model of the cumulative geoid height, influenced by the radial gravity gradient Vzz and three-dimensional gravity gradient Vij are established, respectively. In 250 degrees, the GOCE cumulative geoid height error measured by the radial gravity gradient Vzz is about 2½ times higher than that measured by the three-dimensional gravity gradient Vij. Secondly, the Earth's gravitational field from GOCE completely up to 250 degrees is recovered using the radial gravity gradient Vzz and three-dimensional gravity gradient Vij by numerical simulation, respectively. The study results show that when the measurement error of the gravity gradient is 3 × 10-12/s2, the cumulative geoid height errors using the radial gravity gradient Vzz and three-dimensional gravity gradient Vij are 12.319 cm and 9.295 cm at 250 degrees, respectively. The accuracy of the cumulative geoid height using the three-dimensional gravity gradient Vij is improved by 30%-40% on average compared with that using the radial gravity gradient Vzz in 250 degrees. Finally, by mutual verification of the analytical error model and numerical simulation, the orders of magnitude from the accuracies of the Earth's gravitational field recovery make no substantial differences based on the radial and three-dimensional gravity gradients, respectively. Therefore, it is feasible to develop in advance a radial cold-atom interferometric gradiometer with a measurement accuracy of 10-13/s2-10-15/s2 for precisely producing the next-generation GOCE Follow-On Earth gravity field model with a high spatial resolution.

Investigation of the Effects of MIR-FELIrradiation on the Photoluminescence of Titanium Dioxides

NASA Astrophysics Data System (ADS)

Sonobe, T.; Bakr, M.; Yoshida, K.; Higashimura, K.; Kinjo, R.; Hachiya, K.; Kii, T.; Masuda, K.; Ohgaki, H.

2010-02-01

A mid-infrared free electron laser (MIR-FEL: 5 μm-20 μm) facility (KU-FEL: Kyoto University Free Electron Laser) has been constructed in Institute of Advanced Energy Kyoto University, and first laser saturation at 13.2 μm was achieved in May 2008. Currently, we have started to develop the application of MIR-FEL in the field of energy and material science. This study aimed at investigating the feasibility for the development of new evaluation technique of electron-phonon interaction in metal oxides by MIR-FEL. A preliminary result of electrical and optical properties of titanium dioxides was presented.

X-ray Free-electron Lasers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feldhaus, J.; /DESY; Arthur, J.

In a free-electron laser (FEL) the lasing medium is a high-energy beam of electrons flying with relativistic speed through a periodic magnetic field. The interaction between the synchrotron radiation that is produced and the electrons in the beam induces a periodic bunching of the electrons, greatly increasing the intensity of radiation produced at a particular wavelength. Depending only on a phase match between the electron energy and the magnetic period, the wavelength of the FEL radiation can be continuously tuned within a wide spectral range. The FEL concept can be adapted to produce radiation wavelengths from millimeters to Angstroms, andmore » can in principle produce hard x-ray beams with unprecedented peak brightness, exceeding that of the brightest synchrotron source by ten orders of magnitude or more. This paper focuses on short-wavelength FELs. It reviews the physics and characteristic properties of single-pass FELs, as well as current technical developments aiming for fully coherent x-ray radiation pulses with pulse durations in the 100 fs to 100 as range. First experimental results at wavelengths around 100 nm and examples of scientific applications planned on the new, emerging x-ray FEL facilities are presented.« less

Electron Beam Diagnostics Of The JLAB UV FEL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Evtushenko, Pavel; Benson, Stephen; Biallas, George

2011-03-01

In this contribution we describe various systems and aspects of the electron beam diagnostics of the JLab UV FEL. The FEL is installed on a new bypass beam line at the existing 10 kW IR Upgrade FEL. Here, we describe a set of the following systems. A combination of OTR and phosphor viewers is used for measurements of the transverse beam profile, transverse emittance, and Twiss parameters. This system is also used for alignment of the optical cavity of the UV oscillator and to ensure the overlap between the electron beam and optical mode in the FEL wiggler. A systemmore » of beam position monitors equipped with log-amp based BPM electronics. Bunch length on the order of 120 fs RMS is measured with the help of a modified Martin-Puplett interferometer. The longitudinal transfer function measurement system is used to set up bunch compression in an optimal way, such that the LINAC RF curvature is compensated using only higher order magnetic elements of the beam transport. This set of diagnostic systems made a significant contribution in achieving first lasing of the FEL after only about 60 hours of beam operation.« less

Numerical study of the 3-D effect on FEL performance and its application to the APS LEUTL FEL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chae, Y.C.

A Low-Energy Undulator Test Line (LEUTL) is under construction at the Advanced Photon Source (APS). In LEUTL periodic focusing is provided by external quadrupoles. This results in an elliptical beam with its betatron oscillation envelope varying along the undulators. The free-electron laser (FEL) interaction with such a beam will exhibit truly 3-D effects. Thus the investigation of 3-D effects is important in optimizing the FEL performance. The programs GINGER and TDA3D, coupled with theoretically known facts, have been used for this purpose. Both programs are fully 3-D in moving the particle, but model the interaction between particles and axially symmetricmore » electromagnetic waves. Even though TDA3D can include a few azimuthal modes in the interaction, it is still not a fully 3-D FEL code. However, they show that these 2-D programs can still be used for an elliptical beam whose aspect ratio is within certain limits. The author presents numerical results of FEL performance for the circular beam, the elliptical beam, and finally for the beam in the realistic LEUTL lattice.« less

[Rapid prototyping: a very promising method].

PubMed

Haverman, T M; Karagozoglu, K H; Prins, H-J; Schulten, E A J M; Forouzanfar, T

2013-03-01

Rapid prototyping is a method which makes it possible to produce a three-dimensional model based on two-dimensional imaging. Various rapid prototyping methods are available for modelling, such as stereolithography, selective laser sintering, direct laser metal sintering, two-photon polymerization, laminated object manufacturing, three-dimensional printing, three-dimensional plotting, polyjet inkjet technology,fused deposition modelling, vacuum casting and milling. The various methods currently being used in the biomedical sector differ in production, materials and properties of the three-dimensional model which is produced. Rapid prototyping is mainly usedforpreoperative planning, simulation, education, and research into and development of bioengineering possibilities.

Feasibility of four-dimensional preoperative simulation for elbow debridement arthroplasty.

PubMed

Yamamoto, Michiro; Murakami, Yukimi; Iwatsuki, Katsuyuki; Kurimoto, Shigeru; Hirata, Hitoshi

2016-04-02

Recent advances in imaging modalities have enabled three-dimensional preoperative simulation. A four-dimensional preoperative simulation system would be useful for debridement arthroplasty of primary degenerative elbow osteoarthritis because it would be able to detect the impingement lesions. We developed a four-dimensional simulation system by adding the anatomical axis to the three-dimensional computed tomography scan data of the affected arm in one position. Eleven patients with primary degenerative elbow osteoarthritis were included. A "two rings" method was used to calculate the flexion-extension axis of the elbow by converting the surface of the trochlea and capitellum into two rings. A four-dimensional simulation movie was created and showed the optimal range of motion and the impingement area requiring excision. To evaluate the reliability of the flexion-extension axis, interobserver and intraobserver reliabilities regarding the assessment of bony overlap volumes were calculated twice for each patient by two authors. Patients were treated by open or arthroscopic debridement arthroplasties. Pre- and postoperative examinations included elbow range of motion measurement, and completion of the patient-rated questionnaire Hand20, Japanese Orthopaedic Association-Japan Elbow Society Elbow Function Score, and the Mayo Elbow Performance Score. Measurement of the bony overlap volume showed an intraobserver intraclass correlation coefficient of 0.93 and 0.90, and an interobserver intraclass correlation coefficient of 0.94. The mean elbow flexion-extension arc significantly improved from 101° to 125°. The mean Hand20 score significantly improved from 52 to 22. The mean Japanese Orthopaedic Association-Japan Elbow Society Elbow Function Score significantly improved from 67 to 88. The mean Mayo Elbow Performance Score significantly improved from 71 to 91 at the final follow-up evaluation. We showed that four-dimensional, preoperative simulation can be generated by adding the rotation axis to the one-position, three-dimensional computed tomography image of the affected arm. This method is feasible for elbow debridement arthroplasty.

Direct numerical simulation of steady state, three dimensional, laminar flow around a wall mounted cube

NASA Astrophysics Data System (ADS)

Liakos, Anastasios; Malamataris, Nikolaos

2014-11-01

The topology and evolution of flow around a surface mounted cubical object in three dimensional channel flow is examined for low to moderate Reynolds numbers. Direct numerical simulations were performed via a home made parallel finite element code. The computational domain has been designed according to actual laboratory experimental conditions. Analysis of the results is performed using the three dimensional theory of separation. Our findings indicate that a tornado-like vortex by the side of the cube is present for all Reynolds numbers for which flow was simulated. A horse-shoe vortex upstream from the cube was formed at Reynolds number approximately 1266. Pressure distributions are shown along with three dimensional images of the tornado-like vortex and the horseshoe vortex at selected Reynolds numbers. Finally, and in accordance to previous work, our results indicate that the upper limit for the Reynolds number for which steady state results are physically realizable is roughly 2000. Financial support of author NM from the Office of Naval Research Global (ONRG-VSP, N62909-13-1-V016) is acknowledged.

Three-dimensional spatially curved local Bessel beams generated by metasurface

NASA Astrophysics Data System (ADS)

Liu, Dawei; Wu, Jiawen; Cheng, Bo; Li, Hongliang

2018-03-01

We propose a reflective metasurface based on an artificial admittance modulation surface to generate three-dimensional spatially curved beams. The phase acquisition utilized to modulate this sinusoidally varying surface admittance combines the enveloping theory of differential geometry and the method for producing two-dimensional Bessel beams. The metasurface is fabricated, and the comparison between the full-wave simulations and experimental results demonstrates good performance of three-dimensional spatially curved beams generated by the metasurface.

Emerging Role of Three-Dimensional Printing in Simulation in Otolaryngology.

PubMed

VanKoevering, Kyle K; Malloy, Kelly Michele

2017-10-01

Simulation is rapidly expanding across medicine as a valuable component of trainee education. For procedural simulation, development of low-cost simulators that allow a realistic, haptic experience for learners to practice maneuvers while appreciating anatomy has become highly valuable. Otolaryngology has seen significant advancements in development of improved, specialty-specific simulators with the expansion of three-dimensional (3D) printing. This article highlights the fundamental components of 3D printing and the multitude of subspecialty simulators that have been developed with the assistance of 3D printing. It briefly discusses important considerations such as cost, fidelity, and validation where available in the literature. Copyright © 2017 Elsevier Inc. All rights reserved.

Three-dimensional imaging, an important factor of decision in breast augmentation.

PubMed

de Runz, A; Boccara, D; Bertheuil, N; Claudot, F; Brix, M; Simon, E

2018-04-01

Since the beginning of the 21st century, three-dimensional imaging systems have been used more often in plastic surgery, especially during preoperative planning for breast surgery and to simulate the postoperative appearance of the implant in the patient's body. The main objective of this study is to assess the patients' attitudes regarding 3D simulation for breast augmentation. A study was conducted, which included women who were operated on for primary breast augmentation. During the consultation, a three-dimensional simulation with Crisalix was done and different sized implants were fitted in the bra. Thirty-eight women were included. The median age was 29.4, and the median prosthesis volume was 310mL. The median rank given regarding the final result was 9 (IQR: 8-9). Ninety percent of patients agreed (66% absolutely agreed, and 24% partially agreed) that the final product after breast augmentations was similar to the Crisalix simulation. Ninety-three percent of the patients believed that the three-dimensional simulation helped them choose their prosthesis (61% a lot and 32% a little). After envisaging a breast enlargement, patients estimated that the Crisalix system was absolutely necessary (21%), very useful (32%), useful (45%), or unnecessary (3%). Regarding prosthesis choice, an equal number of women preferred the 3D simulation (19 patients) as preferred using different sizes of implants in the bra (19 patients). The present study demonstrated that 3D simulation is actually useful for patients in order to envisage a breast augmentation. But it should be used as a complement to the classic method of trying different sized breast implants in the bra. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Three-Dimensional Simulation of Traveling-Wave Tube Cold-Test Characteristics Using CST MICROWAVE STUDIO

NASA Technical Reports Server (NTRS)

Chevalier, Christine T.; Herrmann, Kimberly A.; Kory, Carol L.; Wilson, Jeffrey D.; Cross, Andrew W.; Santana , Samuel

2003-01-01

The electromagnetic field simulation software package CST MICROWAVE STUDIO (MWS) was used to compute the cold-test parameters - frequency-phase dispersion, on-axis impedance, and attenuation - for a traveling-wave tube (TWT) slow-wave circuit. The results were compared to experimental data, as well as to results from MAFIA, another three-dimensional simulation code from CST currently used at the NASA Glenn Research Center (GRC). The strong agreement between cold-test parameters simulated with MWS and those measured experimentally demonstrates the potential of this code to reduce the time and cost of TWT development.

Three-Dimensional Numerical Simulation to Mud Turbine for LWD

NASA Astrophysics Data System (ADS)

Yao, Xiaojiang; Dong, Jingxin; Shang, Jie; Zhang, Guanqi

Hydraulic performance analysis was discussed for a type of turbine on generator used for LWD. The simulation models were built by CFD analysis software FINE/Turbo, and full three-dimensional numerical simulation was carried out for impeller group. The hydraulic parameter such as power, speed and pressure drop, were calculated in two kinds of medium water and mud. Experiment was built in water environment. The error of numerical simulation was less than 6%, verified by experiment. Based on this rationalization proposals would be given to choice appropriate impellers, and the rationalization of methods would be explored.

Propagation of relativistic surface harmonics radiation in free space

NASA Astrophysics Data System (ADS)

an der Brügge, Daniel; Pukhov, Alexander

2007-09-01

Relativistic high-harmonics generation from overdense plasma surfaces is studied using three-dimensional particle-in-cell simulations. It is shown that the simple vacuum propagation in the real three-dimensional geometry strongly affects the harmonics spectrum on the optical axis. It may even lead to the formation of attosecond pulses without any special optical filters. To make good use of these effects it is necessary to shape either the laser pulse focal spot, or the surface material in such a way that the S-number of the interaction [see Gordienko and Pukhov, Phys. Plasmas 12, 043109 (2005)] is preserved over the largest possible area. The three-dimensional simulations are carefully compared with the one-dimensional ones. It is shown that the one-dimensional models work well even in cases where the laser is focused to a quite small spot on the harmonics generating surface (σ≈λ).

Invited Article: Coherent imaging using seeded free-electron laser pulses with variable polarization: First results and research opportunities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Capotondi, F.; Pedersoli, E.; Mahne, N.

2013-05-15

FERMI-Elettra, the first vacuum ultraviolet and soft X-ray free-electron laser (FEL) using by default a 'seeded' scheme, became operational in 2011 and has been opened to users since December 2012. The parameters of the seeded FERMI FEL pulses and, in particular, the superior control of emitted radiation in terms of spectral purity and stability meet the stringent requirements for single-shot and resonant coherent diffraction imaging (CDI) experiments. The advantages of the intense seeded FERMI pulses with variable polarization have been demonstrated with the first experiments performed using the multipurpose experimental station operated at the diffraction and projection imaging (DiProI) beamline.more » The results reported here were obtained with fixed non-periodic targets during the commissioning period in 2012 using 20-32 nm wavelength range. They demonstrate that the performance of the FERMI FEL source and the experimental station meets the requirements of CDI, holography, and resonant magnetic scattering in both multi- and single-shot modes. Moreover, we present the first magnetic scattering experiments employing the fully circularly polarized FERMI pulses. The ongoing developments aim at pushing the lateral resolution by using shorter wavelengths provided by double-stage cascaded FERMI FEL-2 and probing ultrafast dynamic processes using different pump-probe schemes, including jitter-free seed laser pump or FEL-pump/FEL-probe with two color FEL pulses generated by the same electron bunch.« less

Metadynamics in the conformational space nonlinearly dimensionally reduced by Isomap

NASA Astrophysics Data System (ADS)

Spiwok, Vojtěch; Králová, Blanka

2011-12-01

Atomic motions in molecules are not linear. This infers that nonlinear dimensionality reduction methods can outperform linear ones in analysis of collective atomic motions. In addition, nonlinear collective motions can be used as potentially efficient guides for biased simulation techniques. Here we present a simulation with a bias potential acting in the directions of collective motions determined by a nonlinear dimensionality reduction method. Ad hoc generated conformations of trans,trans-1,2,4-trifluorocyclooctane were analyzed by Isomap method to map these 72-dimensional coordinates to three dimensions, as described by Brown and co-workers [J. Chem. Phys. 129, 064118 (2008)]. Metadynamics employing the three-dimensional embeddings as collective variables was applied to explore all relevant conformations of the studied system and to calculate its conformational free energy surface. The method sampled all relevant conformations (boat, boat-chair, and crown) and corresponding transition structures inaccessible by an unbiased simulation. This scheme allows to use essentially any parameter of the system as a collective variable in biased simulations. Moreover, the scheme we used for mapping out-of-sample conformations from the 72D to 3D space can be used as a general purpose mapping for dimensionality reduction, beyond the context of molecular modeling.

Cultured High-Fidelity Three-Dimensional Human Urogenital Tract Carcinomas and Process

NASA Technical Reports Server (NTRS)

Goodwin, Thomas J. (Inventor); Prewett, Tacey L. (Inventor); Spaulding, Glenn F. (Inventor); Wolf, David A. (Inventor)

1998-01-01

Artificial high-fidelity three-dimensional human urogenital tract carcinomas are propagated under in vitro-microgravity conditions from carcinoma cells. Artificial high-fidelity three-dimensional human urogenital tract carcinomas are also propagated from a coculture of normal urogenital tract cells inoculated with carcinoma cells. The microgravity culture conditions may be microgravity or simulated microgravity created in a horizontal rotating wall culture vessel.

Contributions of numerical simulation data bases to the physics, modeling and measurement of turbulence

NASA Technical Reports Server (NTRS)

Moin, Parviz; Spalart, Philippe R.

1987-01-01

The use of simulation data bases for the examination of turbulent flows is an effective research tool. Studies of the structure of turbulence have been hampered by the limited number of probes and the impossibility of measuring all desired quantities. Also, flow visualization is confined to the observation of passive markers with limited field of view and contamination caused by time-history effects. Computer flow fields are a new resource for turbulence research, providing all the instantaneous flow variables in three-dimensional space. Simulation data bases also provide much-needed information for phenomenological turbulence modeling. Three dimensional velocity and pressure fields from direct simulations can be used to compute all the terms in the transport equations for the Reynolds stresses and the dissipation rate. However, only a few, geometrically simple flows have been computed by direct numerical simulation, and the inventory of simulation does not fully address the current modeling needs in complex turbulent flows. The availability of three-dimensional flow fields also poses challenges in developing new techniques for their analysis, techniques based on experimental methods, some of which are used here for the analysis of direct-simulation data bases in studies of the mechanics of turbulent flows.

Creating physically-based three-dimensional microstructures: Bridging phase-field and crystal plasticity models.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lim, Hojun; Owen, Steven J.; Abdeljawad, Fadi F.

In order to better incorporate microstructures in continuum scale models, we use a novel finite element (FE) meshing technique to generate three-dimensional polycrystalline aggregates from a phase field grain growth model of grain microstructures. The proposed meshing technique creates hexahedral FE meshes that capture smooth interfaces between adjacent grains. Three dimensional realizations of grain microstructures from the phase field model are used in crystal plasticity-finite element (CP-FE) simulations of polycrystalline a -iron. We show that the interface conformal meshes significantly reduce artificial stress localizations in voxelated meshes that exhibit the so-called "wedding cake" interfaces. This framework provides a direct linkmore » between two mesoscale models - phase field and crystal plasticity - and for the first time allows mechanics simulations of polycrystalline materials using three-dimensional hexahedral finite element meshes with realistic topological features.« less

Spectroscopic, potentiometric and theoretical studies on the binding properties of a novel tripodal polycatechol-imine ligand towards iron(III)

NASA Astrophysics Data System (ADS)

Kanungo, B. K.; Sahoo, Suban K.; Baral, Minati

2008-12-01

A novel multidentate tripodal ligand, cis, cis-1,3,5-tris[(2,3-dihydroxybenzylidene)aminomethyl]cyclohexane (TDBAC, L) containing one catechol unit in each arms of a tripodal amine, cis, cis-1,3,5-tris(aminomethyl)cyclohexane was investigated as a chelator for iron(III) through potentiometric and spectrophotometric methods in an aqueous medium of 0.1N ionic strength and 25 ± 1 °C as well as in ethanol by continuous variation method. From pH metric in water, three protonation constants characterized for the three-hydroxyl groups of the catechol units at ortho were used as input data to evaluate the stability constants of the complexes. Formation of monomeric complexes FeLH 3, FeLH 2, FeLH and FeL were depicted. In ethanol, formation of complexes FeL, Fe 2L and Fe 3L were characterized. Structures of the complexes were explained by using the experimental evidences and predicted through molecular modeling calculations. The ligand showed potential to coordinate iron(III) through three imine nitrogens and three catecholic oxygens at ortho to form a tris(iminocatecholate) type complex.

Discharge Chamber Primary Electron Modeling Activities in Three-Dimensions

NASA Technical Reports Server (NTRS)

Steuber, Thomas J.

2004-01-01

Designing discharge chambers for ion thrusters involves many geometric configuration decisions. Various decisions will impact discharge chamber performance with respect to propellant utilization efficiency, ion production costs, and grid lifetime. These hardware design decisions can benefit from the assistance of computational modeling. Computational modeling for discharge chambers has been limited to two-dimensional codes that leveraged symmetry for interpretation into three-dimensional analysis. This paper presents model development activities towards a three-dimensional discharge chamber simulation to aid discharge chamber design decisions. Specifically, of the many geometric configuration decisions toward attainment of a worthy discharge chamber, this paper focuses on addressing magnetic circuit considerations with a three-dimensional discharge chamber simulation as a tool. With this tool, candidate discharge chamber magnetic circuit designs can be analyzed computationally to gain insight into factors that may influence discharge chamber performance such as: primary electron loss width in magnetic cusps, cathode tip position with respect to the low magnetic field volume, definition of a low magnetic field region, and maintenance of a low magnetic field region across the grid span. Corroborating experimental data will be obtained from mockup hardware tests. Initially, simulated candidate magnetic circuit designs will resemble previous successful thruster designs. To provide opportunity to improve beyond previous performance benchmarks, off-design modifications will be simulated and experimentally tested.

On the role of radiation and dimensionality in predicting flow opposed flame spread over thin fuels

NASA Astrophysics Data System (ADS)

Kumar, Chenthil; Kumar, Amit

2012-06-01

In this work a flame-spread model is formulated in three dimensions to simulate opposed flow flame spread over thin solid fuels. The flame-spread model is coupled to a three-dimensional gas radiation model. The experiments [1] on downward spread and zero gravity quiescent spread over finite width thin fuel are simulated by flame-spread models in both two and three dimensions to assess the role of radiation and effect of dimensionality on the prediction of the flame-spread phenomena. It is observed that while radiation plays only a minor role in normal gravity downward spread, in zero gravity quiescent spread surface radiation loss holds the key to correct prediction of low oxygen flame spread rate and quenching limit. The present three-dimensional simulations show that even in zero gravity gas radiation affects flame spread rate only moderately (as much as 20% at 100% oxygen) as the heat feedback effect exceeds the radiation loss effect only moderately. However, the two-dimensional model with the gas radiation model badly over-predicts the zero gravity flame spread rate due to under estimation of gas radiation loss to the ambient surrounding. The two-dimensional model was also found to be inadequate for predicting the zero gravity flame attributes, like the flame length and the flame width, correctly. The need for a three-dimensional model was found to be indispensable for consistently describing the zero gravity flame-spread experiments [1] (including flame spread rate and flame size) especially at high oxygen levels (>30%). On the other hand it was observed that for the normal gravity downward flame spread for oxygen levels up to 60%, the two-dimensional model was sufficient to predict flame spread rate and flame size reasonably well. Gas radiation is seen to increase the three-dimensional effect especially at elevated oxygen levels (>30% for zero gravity and >60% for normal gravity flames).

A new procedure for investigating three-dimensional stress fields in a thin plate with a through-the-thickness crack

NASA Astrophysics Data System (ADS)

Yi, Dake; Wang, TzuChiang

2018-06-01

In the paper, a new procedure is proposed to investigate three-dimensional fracture problems of a thin elastic plate with a long through-the-thickness crack under remote uniform tensile loading. The new procedure includes a new analytical method and high accurate finite element simulations. In the part of theoretical analysis, three-dimensional Maxwell stress functions are employed in order to derive three-dimensional crack tip fields. Based on the theoretical analysis, an equation which can describe the relationship among the three-dimensional J-integral J( z), the stress intensity factor K( z) and the tri-axial stress constraint level T z ( z) is derived first. In the part of finite element simulations, a fine mesh including 153360 elements is constructed to compute the stress field near the crack front, J( z) and T z ( z). Numerical results show that in the plane very close to the free surface, the K field solution is still valid for in-plane stresses. Comparison with the numerical results shows that the analytical results are valid.

Analysis of absorption and reflection mechanisms in a three-dimensional plate silencer

NASA Astrophysics Data System (ADS)

Wang, Chunqi; Huang, Lixi

2008-06-01

When a segment of a rigid duct is replaced by a plate backed by a hard-walled cavity, grazing incident sound waves induce plate vibration, hence sound reflection. Based on this mechanism, a broadband plate silencer, which works effectively from low-to-medium frequencies have been developed recently. A typical plate silencer consists of an expansion chamber with two side-branch cavities covered by light but extremely stiff plates. Such a configuration is two-dimensional in nature. In this paper, numerical study is extended to three-dimensional configurations to investigate the potential improvement in sound reflection. Finite element simulation shows that the three-dimensional configurations perform better than the corresponding two-dimensional design, especially in the relatively high frequency region. Further analysis shows that the three-dimensional design gives better plate response at higher axial modes than the simple two-dimensional design. Sound absorption mechanism is also introduced to the plate silencer by adding two dissipative chambers on the two lateral sides of a two-cavity wave reflector, hence a hybrid silencer. Numerical simulation shows that the proposed hybrid silencer is able to achieve a good moderate bandwidth with much reduced total length in comparison with pure absorption design.

In-pixel conversion with a 10 bit SAR ADC for next generation X-ray FELs

NASA Astrophysics Data System (ADS)

Lodola, L.; Batignani, G.; Benkechkache, M. A.; Bettarini, S.; Casarosa, G.; Comotti, D.; Dalla Betta, G. F.; Fabris, L.; Forti, F.; Grassi, M.; Latreche, S.; Malcovati, P.; Manghisoni, M.; Mendicino, R.; Morsani, F.; Paladino, A.; Pancheri, L.; Paoloni, E.; Ratti, L.; Re, V.; Rizzo, G.; Traversi, G.; Vacchi, C.; Verzellesi, G.; Xu, H.

2016-07-01

This work presents the design of an interleaved Successive Approximation Register (SAR) ADC, part of the readout channel for the PixFEL detector. The PixFEL project aims at substantially advancing the state-of-the-art in the field of 2D X-ray imaging for applications at the next generation Free Electron Laser (FEL) facilities. For this purpose, the collaboration is developing the fundamental microelectronic building blocks for the readout channel. This work focuses on the design of the ADC carried out in a 65 nm CMOS technology. To obtain a good tradeoff between power consumption, conversion speed and area occupation, an interleaved SAR ADC architecture was adopted.

Direct Harmonic Linear Navier-Stokes Methods for Efficient Simulation of Wave Packets

NASA Technical Reports Server (NTRS)

Streett, C. L.

1998-01-01

Wave packets produced by localized disturbances play an important role in transition in three-dimensional boundary layers, such as that on a swept wing. Starting with the receptivity process, we show the effects of wave-space energy distribution on the development of packets and other three-dimensional disturbance patterns. Nonlinearity in the receptivity process is specifically addressed, including demonstration of an effect which can enhance receptivity of traveling crossflow disturbances. An efficient spatial numerical simulation method is allowing most of the simulations presented to be carried out on a workstation.

Three-dimensional phase-field simulations of directional solidification

NASA Astrophysics Data System (ADS)

Plapp, Mathis

2007-05-01

The phase-field method has become the method of choice for simulating microstructural pattern formation during solidification. One of its main advantages is that time-dependent three-dimensional simulations become feasible, which makes it possible to address long-standing questions of pattern stability and pattern selection. Here, a brief introduction to the phase-field model and its implementation is given, and its capabilities are illustrated by examples taken from the directional solidification of binary alloys. In particular, the morphological stability of hexagonal cellular arrays and of eutectic lamellar patterns is investigated.

Applications of the Lattice Boltzmann Method to Complex and Turbulent Flows

NASA Technical Reports Server (NTRS)

Luo, Li-Shi; Qi, Dewei; Wang, Lian-Ping; Bushnell, Dennis M. (Technical Monitor)

2002-01-01

We briefly review the method of the lattice Boltzmann equation (LBE). We show the three-dimensional LBE simulation results for a non-spherical particle in Couette flow and 16 particles in sedimentation in fluid. We compare the LBE simulation of the three-dimensional homogeneous isotropic turbulence flow in a periodic cubic box of the size 1283 with the pseudo-spectral simulation, and find that the two results agree well with each other but the LBE method is more dissipative than the pseudo-spectral method in small scales, as expected.

[New simulation technologies in neurosurgery].

PubMed

Byvaltsev, V A; Belykh, E G; Konovalov, N A

2016-01-01

The article presents a literature review on the current state of simulation technologies in neurosurgery, a brief description of the basic technology and the classification of simulation models, and examples of simulation models and skills simulators used in neurosurgery. Basic models for the development of physical skills, the spectrum of available computer virtual simulators, and their main characteristics are described. It would be instructive to include microneurosurgical training and a cadaver course of neurosurgical approaches in neurosurgery training programs and to extend the use of three-dimensional imaging. Technologies for producing three-dimensional anatomical models and patient-specific computer simulators as well as improvement of tactile feedback systems and display quality of virtual models are promising areas. Continued professional education necessitates further research for assessing the validity and practical use of simulators and physical models.

Computer Simulation of Spatial Arrangement and Connectivity of Particles in Three-Dimensional Microstructure: Application to Model Electrical Conductivity of Polymer Matrix Composite

NASA Technical Reports Server (NTRS)

Louis, P.; Gokhale, A. M.

1996-01-01

Computer simulation is a powerful tool for analyzing the geometry of three-dimensional microstructure. A computer simulation model is developed to represent the three-dimensional microstructure of a two-phase particulate composite where particles may be in contact with one another but do not overlap significantly. The model is used to quantify the "connectedness" of the particulate phase of a polymer matrix composite containing hollow carbon particles in a dielectric polymer resin matrix. The simulations are utilized to estimate the morphological percolation volume fraction for electrical conduction, and the effective volume fraction of the particles that actually take part in the electrical conduction. The calculated values of the effective volume fraction are used as an input for a self-consistent physical model for electrical conductivity. The predicted values of electrical conductivity are in very good agreement with the corresponding experimental data on a series of specimens having different particulate volume fraction.

Three dimensional geometric modeling of processing-tomatoes

USDA-ARS?s Scientific Manuscript database

Characterizing tomato geometries with different shapes and sizes would facilitate the design of tomato processing equipments and promote computer-based engineering simulations. This research sought to develop a three-dimensional geometric model that can describe the morphological attributes of proce...

Drag and drop simulation: from pictures to full three-dimensional simulations

NASA Astrophysics Data System (ADS)

Bergmann, Michel; Iollo, Angelo

2014-11-01

We present a suite of methods to achieve ``drag and drop'' simulation, i.e., to fully automatize the process to perform thee-dimensional flow simulations around a bodies defined by actual images of moving objects. The overall approach requires a skeleton graph generation to get level set function from pictures, optimal transportation to get body velocity on the surface and then flow simulation thanks to a cartesian method based on penalization. We illustrate this paradigm simulating the swimming of a mackerel fish.

Three-dimensional Mesoscale Simulations of Detonation Initiation in Energetic Materials with Density-based Kinetics

NASA Astrophysics Data System (ADS)

Jackson, Thomas; Jost, A. M.; Zhang, Ju; Sridharan, P.; Amadio, G.

2017-06-01

In this work we present three-dimensional mesoscale simulations of detonation initiation in energetic materials. We solve the reactive Euler equations, with the energy equation augmented by a power deposition term. The reaction rate at the mesoscale is modelled using a density-based kinetics scheme, adapted from standard Ignition and Growth models. The deposition term is based on previous results of simulations of pore collapse at the microscale, modelled at the mesoscale as hot-spots. We carry out three-dimensional mesoscale simulations of random packs of HMX crystals in a binder, and show that the transition between no-detonation and detonation depends on the number density of the hot-spots, the initial radius of the hot-spot, the post-shock pressure of an imposed shock, and the amplitude of the power deposition term. The trends of transition at lower pressure of the imposed shock for larger number density of pore observed in experiments is reproduced. Initial attempts to improve the agreement between the simulation and experiments through calibration of various parameters will also be made.

SU-E-I-91: Development of a Compact Radiographic Simulator Using Microsoft Kinect.

PubMed

Ono, M; Kozono, K; Aoki, M; Mizoguchi, A; Kamikawa, Y; Umezu, Y; Arimura, H; Toyofuku, F

2012-06-01

Radiographic simulator system is useful for learning radiographic techniques and confirmation of positioning before x-ray irradiation. Conventional x-ray simulators have drawbacks in cost and size, and are only applicable to situations in which position of the object does not change. Therefore, we have developed a new radiographic simulator system using an infrared-ray based three-dimensional shape measurement device (Microsoft Kinect). We made a computer program using OpenCV and OpenNI for processing of depth image data obtained from Kinect, and calculated the exact distance from Kinect to the object by calibration. Theobject was measured from various directions, and positional relationship between the x-ray tube and the object was obtained. X-ray projection images were calculated by projecting x-rays onto the mathematical three-dimensional CT data of a head phantom with almost the same size. The object was rotated from 0 degree (standard position) through 90 degrees in increments of 10 degrees, and the accuracy of the measured rotation angle values was evaluated. In order to improve the computational time, the projection image size was changed (512*512, 256*256, and 128*128). The x-ray simulation images corresponding to the radiographic images produced by using the x-ray tube were obtained. The three-dimensional position of the object was measured with good precision from 0 to 50 degrees, but above 50 degrees, measured position error increased with the increase of the rotation angle. The computational time and image size were 30, 12, and 7 seconds for 512*512, 256*256, and 128*128, respectively. We could measure the three-dimensional position of the object using properly calibrated Kinect sensor, and obtained projection images at relatively high-speed using the three-dimensional CTdata. It was suggested that this system can be used for obtaining simulated projection x-ray images before x-ray exposure by attaching this device onto an x-ray tube. © 2012 American Association of Physicists in Medicine.

GENETIC EVOLUTION OF BACTERIOPHAGE, I. HYBRIDS BETWEEN UNRELATED BACTERIOPHAGES P22 AND FELS 2*

PubMed Central

Yamamoto, Nobuto

1969-01-01

A new bacteriophage species, designated F22, was isolated from phage P22 stocks grown on Salmonella typhimurium Q1 lysogenic for Fels 2 at a frequency of less than 10-11. P22 has a very short tail with a hexagonal base plate and six spikes. Phage Fels 2 is morphologically similar to E. coli T-even phages, having a long tail with a contractile sheath and carrying no genetic region related to P22. Phage F22 is morphologically and serologically indistinguishable from Fels 2, but carries the c(c1, c2, and c3) markers of P22. The color markers h21, g, and m3 of P22 do not appear in F22. Thus, F22 is evidently a recombinant between the unrelated bacteriophages P22 and Fels 2. The recombination between unrelated bacteriophages could play an important role in the evolution of bacteriophages. Images PMID:4890254

An XUV/VUV free-electron laser oscillator

NASA Astrophysics Data System (ADS)

Goldstein, J. C.; Newnam, B. E.; Cooper, R. K.; Comly, J. C., Jr.

Problems regarding the extension of free-electron laser technology from the visible and near infrared region, where such devices are currently operating, to the ultraviolet have recently been extensively discussed. It was found that significant technical problems must be overcome before free-electron lasers (FELs) can be operated in the VUV (100-200 nm) and the XUV (50-100). However, the present lack of other intense and tunable sources of coherent radiation at these wavelengths together with the intrinsic properties of FELs make the development of such devices potentially very rewarding. The properties of FELs include continuous tunability in wavelength and output in the form of a train of picosecond pulses. An investigation is conducted regarding the feasibility of an operation of a FEL in the XUV/VUV regions, taking into account a theoretical model. It is found that modest improvements in electron beam and optical mirror technologies will make the design of a FEL for operation in the 50-200-nm range of optical wavelength possible.

Modeling self-excited combustion instabilities using a combination of two- and three-dimensional simulations

NASA Astrophysics Data System (ADS)

Harvazinski, Matthew Evan

Self-excited combustion instabilities have been studied using a combination of two- and three-dimensional computational fluid dynamics (CFD) simulations. This work was undertaken to assess the ability of CFD simulations to generate the high-amplitude resonant combustion dynamics without external forcing or a combustion response function. Specifically, detached eddy simulations (DES), which allow for significantly coarser grid resolutions in wall bounded flows than traditional large eddy simulations (LES), were investigated for their capability of simulating the instability. A single-element laboratory rocket combustor which produces self-excited longitudinal instabilities is used for the configuration. The model rocket combustor uses an injector configuration based on practical oxidizer-rich staged-combustion devices; a sudden expansion combustion section; and uses decomposed hydrogen peroxide as the oxidizer and gaseous methane as the fuel. A better understanding of the physics has been achieved using a series of diagnostics. Standard CFD outputs like instantaneous and time averaged flowfield outputs are combined with other tools, like the Rayleigh index to provide additional insight. The Rayleigh index is used to identify local regions in the combustor which are responsible for driving and damping the instability. By comparing the Rayleigh index to flowfield parameters it is possible to connect damping and driving to specific flowfield conditions. A cost effective procedure to compute multidimensional local Rayleigh index was developed. This work shows that combustion instabilities can be qualitatively simulated using two-dimensional axisymmetric simulations for fuel rich operating conditions. A full three-dimensional simulation produces a higher level of instability which agrees quite well with the experimental results. In addition to matching the level of instability the three-dimensional simulation also predicts the harmonic nature of the instability that is observed in experiments. All fuel rich simulations used a single step global reaction for the chemical kinetic model. A fuel lean operating condition is also studied and has a lower level of instability. The two-dimensional results are unable to provide good agreement with experimental results unless a more expensive four-step chemical kinetic model is used. The three-dimensional simulation is able to predict the harmonic behavior but fails to capture the amplitude of the instability observed in the companion experiment, instead predicting lower amplitude oscillations. A detailed analysis of the three-dimensional results on a single cycle shows that the periodic heat release commonly associated with combustion instability can be interpreted to be a result of the time lag between the instant the fuel is injected and when it is burned. The time lag is due to two mechanisms. First, methane present near the backstep can become trapped and transported inside shed vortices to the point of combustion. The second aspect of the time lag arises due to the interaction of the fuel with upstream-running pressure waves. As the wave moves past the injection point the flow is temporarily disrupted, reducing the fuel flow into the combustor. A comparison between the fuel lean and fuel rich cases shows several differences. Whereas both cases can produce instability, the fuel-rich case is measurably more unstable. Using the tools developed differences in the location of the damping, and driving regions are evident. By moving the peak driving area upstream of the damping region the level of instability is lower in the fuel lean case. The location of the mean heat release is also important; locating the mean heat release adjacent to the vortex impingement point a higher level of instability is observed for the fuel rich case. This research shows that DES instability modeling has the ability to be a valuable tool in the study of combustion instability. The lower grid size requirement makes the use of DES based modeling a potential candidate in the modeling of full-scale rocket engines. Whereas three-dimensional simulations may be necessary for very good agreement, two-dimensional simulations allow efficient parametric investigation and tool development. The insights obtained from the simulations offer the possibility that their results can be used in the design of future engines to exploit damping and reduce driving.

Research on three-dimensional real scene technology of Sichuan-Tibet highway

NASA Astrophysics Data System (ADS)

Yin, Peng; Bo, Xianglei; Liu, Fen

2018-04-01

This paper studies the three-dimensional real scene technology in the application of highway simulation, and a system to realize three-dimensional real scene of Sichuan-Tibet highway is presented. This system can improve the defect of the traditional Sichuan-Tibet highway geographic information system from performance and feeling. The Tibet forces can use this system to improve motor adaptive training effect and command decision-making ability.

40 CFR 1045.706 - How do I generate and calculate evaporative emission credits?

Code of Federal Regulations, 2010 CFR

2010-07-01

... emission standard, in g/m2/day. FEL = the family emission limit for the family, in g/m2/day, as described... emission families with FELs at or above 5.0 g/m2/day. To calculate emission credits for such emission... FEL of 10.4 g/m2/day. This would apply without regard to whether any of these emission families have...

A 1kW EUV source for lithography based on FEL emission in a compact storage ring

NASA Astrophysics Data System (ADS)

Feser, Michael; Ruth, Ron; Loewen, Rod

2017-10-01

EUV has long been hailed as the next generation lithography technology. Its adoption into high volume manufacturing (HVM), however, has been delayed several technology nodes due to technical issues, many of which can be attributed to the EUV source performance. Today's EUV lithography scanners are powered by laser produce plasma (LPP) sources. They have issues with power scaling beyond 300 W, reliability and contamination. Free Electron Lasers (FELs) have been considered as an alternative EUV source. Advantages of accelerator based sources are the maturity of the accelerator technology, lack of debris/contamination, and ability to provide high power. Industry turned away from this technology because of the requirement to feed up to 10 scanners from one linear FEL to make it economically feasible, the large footprint, and generation of radioactive byproducts. All of these issues are overcome in the presented concept using a compact storage ring with steady-state FEL lasing action. At 1 kW output power, comparable cost and footprint to an LPP source, this source is ideally suited for use on a single scanner and promises reliable, contamination free operation. FEL action in the storage ring is sustained by operating the FEL well below the saturation regime and preserving the equilibrium low emittance and energy distribution of the ring.

PFM2: a 32 × 32 processor for X-ray diffraction imaging at FELs

NASA Astrophysics Data System (ADS)

Manghisoni, M.; Fabris, L.; Re, V.; Traversi, G.; Ratti, L.; Grassi, M.; Lodola, L.; Malcovati, P.; Vacchi, C.; Pancheri, L.; Benkechcache, M. E. A.; Dalla Betta, G.-F.; Xu, H.; Verzellesi, G.; Ronchin, S.; Boscardin, M.; Batignani, G.; Bettarini, S.; Casarosa, G.; Forti, F.; Giorgi, M.; Paladino, A.; Paoloni, E.; Rizzo, G.; Morsani, F.

2016-11-01

This work is concerned with the design of a readout chip for application to experiments at the next generation X-ray Free Electron Lasers (FEL). The ASIC, named PixFEL Matrix (PFM2), has been designed in a 65 nm CMOS technology and consists of 32 × 32 pixels. Each cell covers an area of 110 × 110 μm2 and includes a low-noise charge sensitive amplifier (CSA) with dynamic signal compression, a time-variant shaper used to process the preamplifier output signal, a 10-bit successive approximation register (SAR) analog-to-digital converter (ADC) and digital circuitry for channel control and data readout. Two different solutions for the readout channel, based on different versions of the time-variant filter, have been integrated in the chip. Both solutions can be operated in such a way to cope with the high frame rate (exceeding 1 MHz) foreseen for future X-ray FEL machines. The ASIC will be bump bonded to a slim/active edge pixel sensor to form the first demonstrator for the PixFEL X-ray imager. This work has been carried out in the frame of the PixFEL project funded by Istituto Nazionale di Fisica Nucleare (INFN), Italy.

Modeling unstable alcohol flooding of DNAPL-contaminated columns

NASA Astrophysics Data System (ADS)

Roeder, Eberhard; Falta, Ronald W.

Alcohol flooding, consisting of injection of a mixture of alcohol and water, is one source removal technology for dense non-aqueous phase liquids (DNAPLs) currently under investigation. An existing compositional multiphase flow simulator (UTCHEM) was adapted to accurately represent the equilibrium phase behavior of ternary and quaternary alcohol/DNAPL systems. Simulator predictions were compared to laboratory column experiments and the results are presented here. It was found that several experiments involved unstable displacements of the NAPL bank by the alcohol flood or of the alcohol flood by the following water flood. Unstable displacement led to additional mixing compared to ideal displacement. This mixing was approximated by a large dispersion in one-dimensional simulations and or by including permeability heterogeneities on a very small scale in three-dimensional simulations. Three-dimensional simulations provided the best match. Simulations of unstable displacements require either high-resolution grids, or need to consider the mixing of fluids in a different manner to capture the resulting effects on NAPL recovery.

3DHYDROGEOCHEM: A 3-DIMENSIONAL MODEL OF DENSITY-DEPENDENT SUBSURFACE FLOW AND THERMAL MULTISPECIES-MULTICOMPONENT HYDROGEOCHEMICAL TRANSPORT (EPA/600/SR-98/159)

EPA Science Inventory

This report presents a three-dimensional finite-element numerical model designed to simulate chemical transport in subsurface systems with temperature effect taken into account. The three-dimensional model is developed to provide (1) a tool of application, with which one is able ...

Time-Accurate Numerical Simulations of Synthetic Jet Quiescent Air

NASA Technical Reports Server (NTRS)

Rupesh, K-A. B.; Ravi, B. R.; Mittal, R.; Raju, R.; Gallas, Q.; Cattafesta, L.

2007-01-01

The unsteady evolution of three-dimensional synthetic jet into quiescent air is studied by time-accurate numerical simulations using a second-order accurate mixed explicit-implicit fractional step scheme on Cartesian grids. Both two-dimensional and three-dimensional calculations of synthetic jet are carried out at a Reynolds number (based on average velocity during the discharge phase of the cycle V(sub j), and jet width d) of 750 and Stokes number of 17.02. The results obtained are assessed against PIV and hotwire measurements provided for the NASA LaRC workshop on CFD validation of synthetic jets.

Simulation of TunneLadder traveling-wave tube cold-test characteristics: Implementation of the three-dimensional, electromagnetic circuit analysis code micro-SOS

NASA Technical Reports Server (NTRS)

Kory, Carol L.; Wilson, Jeffrey D.

1993-01-01

The three-dimensional, electromagnetic circuit analysis code, Micro-SOS, can be used to reduce expensive time-consuming experimental 'cold-testing' of traveling-wave tube (TWT) circuits. The frequency-phase dispersion characteristics and beam interaction impedance of a TunneLadder traveling-wave tube slow-wave structure were simulated using the code. When reasonable dimensional adjustments are made, computer results agree closely with experimental data. Modifications to the circuit geometry that would make the TunneLadder TWT easier to fabricate for higher frequency operation are explored.

Quantification of Fel d 1 in house dust samples of cat allergic patients by using monoclonal antibody specific to a novel IgE-binding epitope.

PubMed

Tasaniyananda, Natt; Tungtrongchitr, Anchalee; Seesuay, Watee; Sakolvaree, Yuwaporn; Aiumurai, Pisinee; Indrawattana, Nitaya; Chaicumpa, Wanpen; Sookrung, Nitat

2018-03-01

Avoidance of allergen exposure is an effective measure for preventing naÏve and allergic individuals from sensitization (primary intervention) and disease aggravation (secondary intervention), respectively. Regular monitoring of the allergens in the environment is required for the effective intervention. Thus, there is a need for cost-effective test kits for environmental allergen quantifications. To invent a test kit for quantification of cat major allergen, Fel d 1. A mouse monoclonal antibody (MAb) specific to the newly identified IgE-binding conformational epitope of the cat major allergen (Fel d 1) and rabbit polyclonal IgG to recombinant Fel d 1 were used as allergen capture and detection reagents, respectively. Native Fel d 1 was used in constructing a standard curve. Sixteen of 36 dust samples collected from houses of cat allergic subjects in Bangkok contained Fel d 1 above 0.29 μg/gram of dust which is considered as a novel threshold level for causing cat allergy sensitization or symptoms. Among them, 7 samples contained the allergen exceeding 2.35 μg/gram of dust which is the level that would aggravate asthma. Results of the allergen quantification using the locally made test kit showed strong correlation (r = 0.923) with the allergen quantification using commercialized reagents. The assay using MAb to Fel d 1 IgE-binding epitope of this study has potential application as an economic and practical tool for cat allergy intervention measure especially in localities where health resources are relatively limited.

Chronic cat allergen exposure induces a TH2 cell-dependent IgG4 response related to low sensitization.

PubMed

Renand, Amedee; Archila, Luis D; McGinty, John; Wambre, Erik; Robinson, David; Hales, Belinda J; Thomas, Wayne R; Kwok, William W

2015-12-01

In human subjects, allergen tolerance has been observed after high-dose allergen exposure or after completed allergen immunotherapy, which is related to the accumulation of anti-inflammatory IgG4. However, the specific T-cell response that leads to IgG4 induction during chronic allergen exposure remains poorly understood. We sought to evaluate the relationship between cat allergen-specific T-cell frequency, cat allergen-specific IgE and IgG4 titers, and clinical status in adults with cat allergy with and without cat ownership and the cellular mechanism by which IgG4 is produced. Fel d 1-, Fel d 4-, Fel d 7-, and Fel d 8-specific T-cell responses were characterized by CD154 expression after antigen stimulation. In allergic subjects without cat ownership, the frequency of cat allergen (Fel d 1 and Fel d 4)-specific TH2 (sTH2) cells correlates with higher IgE levels and is linked to asthma. Paradoxically, we observed that subjects with cat allergy and chronic cat exposure maintain a high frequency of sTH2 cells, which correlates with higher IgG4 levels and low sensitization. B cells from allergic, but not nonallergic subjects, are able to produce IgG4 after cognate interactions with sTH2 clones and Fel d 1 peptide or the Fel d 1 recombinant protein. These experiments suggest that (1) allergen-experienced B cells with the capacity to produce IgG4 are present in allergic subjects and (2) cat allergen exposure induces an IgG4 response in a TH2 cell-dependent manner. Thus IgG4 accumulation could be mediated by chronic activation of the TH2 response, which in turn drives desensitization. Copyright © 2015 American Academy of Allergy, Asthma & Immunology. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ratner, D.; Behrens, C.; Ding, Y.

The microbunching instability (MBI) is a well known problem for high brightness electron beams and has been observed at accelerator facilities around the world. Free-electron lasers (FELs) are particularly susceptible to MBI, which can distort the longitudinal phase space and increase the beam’s slice energy spread (SES). Past studies of MBI at the Linac Coherent Light Source (LCLS) relied on optical transition radiation to infer the existence of microbunching. With the development of the x-band transverse deflecting cavity (XTCAV), we can for the first time directly image the longitudinal phase space at the end of the accelerator and complete amore » comprehensive study of MBI, revealing both detailed MBI behavior as well as insights into mitigation schemes. The fine time resolution of the XTCAV also provides the first LCLS measurements of the final SES, a critical parameter for many advanced FEL schemes. As a result, detailed MBI and SES measurements can aid in understanding MBI mechanisms, benchmarking simulation codes, and designing future high- brightness accelerators.« less

Saturation of side-band instabilities in a free-electron laser

NASA Astrophysics Data System (ADS)

Lin, A. T.

The efficiency of a free electron laser is intrinsically limited because the growth of the ponderomotive force produced by the interaction of the rippled magnetic field and the signal wave will eventually trap the electrons. There are a number of approaches for enhancing the efficiency of a free electron laser (FEL). One approach employs a dc field. Most of the efficiency enhancement calculations use a single-mode approximation which prohibits the side band waves to grow. In the present investigation, a particle simulation procedure is employed to demonstrate that the enhancement process is ultimately terminated by the generation of side band instabilities due to the interaction of the trapped electrons and the signal wave. The side band instability will play an important part in determining the maximum output power which can be obtained from a FEL. It is also shown that a considerable improvement in output power can still be achieved by carefully choosing the strength and the turn-on time of the dc electric field.

The Multi-dimensional Character of Core-collapse Supernovae

DOE PAGES

Hix, W. R.; Lentz, E. J.; Bruenn, S. W.; ...

2016-03-01

Core-collapse supernovae, the culmination of massive stellar evolution, are spectacular astronomical events and the principle actors in the story of our elemental origins. Our understanding of these events, while still incomplete, centers around a neutrino-driven central engine that is highly hydrodynamically unstable. Increasingly sophisticated simulations reveal a shock that stalls for hundreds of milliseconds before reviving. Though brought back to life by neutrino heating, the development of the supernova explosion is inextricably linked to multi-dimensional fluid flows. In this paper, the outcomes of three-dimensional simulations that include sophisticated nuclear physics and spectral neutrino transport are juxtaposed to learn about themore » nature of the three-dimensional fluid flow that shapes the explosion. Comparison is also made between the results of simulations in spherical symmetry from several groups, to give ourselves confidence in the understanding derived from this juxtaposition.« less

Injector Beam Dynamics for a High-Repetition Rate 4th-Generation Light Source

DOE Office of Scientific and Technical Information (OSTI.GOV)

Papadopoulos, C. F.; Corlett, J.; Emma, P.

2013-05-20

We report on the beam dynamics studies and optimization methods for a high repetition rate (1 MHz) photoinjector based on a VHF normal conducting electron source. The simultaneous goals of beamcompression and reservation of 6-dimensional beam brightness have to be achieved in the injector, in order to accommodate a linac driven FEL light source. For this, a parallel, multiobjective optimization algorithm is used. We discuss the relative merits of different injector design points, as well as the constraints imposed on the beam dynamics by technical considerations such as the high repetition rate.

An intermediate-scale model for thermal hydrology in low-relief permafrost-affected landscapes

DOE PAGES

Jan, Ahmad; Coon, Ethan T.; Painter, Scott L.; ...

2017-07-10

Integrated surface/subsurface models for simulating the thermal hydrology of permafrost-affected regions in a warming climate have recently become available, but computational demands of those new process-rich simu- lation tools have thus far limited their applications to one-dimensional or small two-dimensional simulations. We present a mixed-dimensional model structure for efficiently simulating surface/subsurface thermal hydrology in low-relief permafrost regions at watershed scales. The approach replaces a full three-dimensional system with a two-dimensional overland thermal hydrology system and a family of one-dimensional vertical columns, where each column represents a fully coupled surface/subsurface thermal hydrology system without lateral flow. The system is then operatormore » split, sequentially updating the overland flow system without sources and the one-dimensional columns without lateral flows. We show that the app- roach is highly scalable, supports subcycling of different processes, and compares well with the corresponding fully three-dimensional representation at significantly less computational cost. Those advances enable recently developed representations of freezing soil physics to be coupled with thermal overland flow and surface energy balance at scales of 100s of meters. Furthermore developed and demonstrated for permafrost thermal hydrology, the mixed-dimensional model structure is applicable to integrated surface/subsurface thermal hydrology in general.« less

Computer Simulation For Design Of TWT's

NASA Technical Reports Server (NTRS)

Bartos, Karen F.; Fite, E. Brian; Shalkhauser, Kurt A.; Sharp, G. Richard

1992-01-01

A three-dimensional finite-element analytical technique facilitates design and fabrication of traveling-wave-tube (TWT) slow-wave structures. Used to perform thermal and mechanical analyses of TWT designed with variety of configurations, geometries, and materials. Using three-dimensional computer analysis, designer able to simulate building and testing of TWT, with consequent substantial saving of time and money. Technique enables detailed look into operation of traveling-wave tubes to help improve performance for future communications systems.

Coarse-grained mechanics of viral shells

NASA Astrophysics Data System (ADS)

Klug, William S.; Gibbons, Melissa M.

2008-03-01

We present an approach for creating three-dimensional finite element models of viral capsids from atomic-level structural data (X-ray or cryo-EM). The models capture heterogeneous geometric features and are used in conjunction with three-dimensional nonlinear continuum elasticity to simulate nanoindentation experiments as performed using atomic force microscopy. The method is extremely flexible; able to capture varying levels of detail in the three-dimensional structure. Nanoindentation simulations are presented for several viruses: Hepatitis B, CCMV, HK97, and φ29. In addition to purely continuum elastic models a multiscale technique is developed that combines finite-element kinematics with MD energetics such that large-scale deformations are facilitated by a reduction in degrees of freedom. Simulations of these capsid deformation experiments provide a testing ground for the techniques, as well as insight into the strength-determining mechanisms of capsid deformation. These methods can be extended as a framework for modeling other proteins and macromolecular structures in cell biology.

Preliminary Groundwater Simulations To Compare Different Reconstruction Methods of 3-d Alluvial Heterogeneity

NASA Astrophysics Data System (ADS)

Teles, V.; de Marsily, G.; Delay, F.; Perrier, E.

Alluvial floodplains are extremely heterogeneous aquifers, whose three-dimensional structures are quite difficult to model. In general, when representing such structures, the medium heterogeneity is modeled with classical geostatistical or Boolean meth- ods. Another approach, still in its infancy, is called the genetic method because it simulates the generation of the medium by reproducing sedimentary processes. We developed a new genetic model to obtain a realistic three-dimensional image of allu- vial media. It does not simulate the hydrodynamics of sedimentation but uses semi- empirical and statistical rules to roughly reproduce fluvial deposition and erosion. The main processes, either at the stream scale or at the plain scale, are modeled by simple rules applied to "sediment" entities or to conceptual "erosion" entities. The model was applied to a several kilometer long portion of the Aube River floodplain (France) and reproduced the deposition and erosion cycles that occurred during the inferred climate periods (15 000 BP to present). A three-dimensional image of the aquifer was gener- ated, by extrapolating the two-dimensional information collected on a cross-section of the floodplain. Unlike geostatistical methods, this extrapolation does not use a statis- tical spatial analysis of the data, but a genetic analysis, which leads to a more realistic structure. Groundwater flow and transport simulations in the alluvium were carried out with a three-dimensional flow code or simulator (MODFLOW), using different rep- resentations of the alluvial reservoir of the Aube River floodplain: first an equivalent homogeneous medium, and then different heterogeneous media built either with the traditional geostatistical approach simulating the permeability distribution, or with the new genetic model presented here simulating sediment facies. In the latter case, each deposited entity of a given lithology was assigned a constant hydraulic conductivity value. Results of these models have been compared to assess the value of the genetic approach and will be presented.

The Coupling of Finite Element and Integral Equation Representations for Efficient Three-Dimensional Modeling of Electromagnetic Scattering and Radiation

NASA Technical Reports Server (NTRS)

Cwik, Tom; Zuffada, Cinzia; Jamnejad, Vahraz

1996-01-01

Finite element modeling has proven useful for accurtely simulating scattered or radiated fields from complex three-dimensional objects whose geometry varies on the scale of a fraction of a wavelength.

Life Origination Hydrate Theory (LOH-Theory) and Mitosis and Replication Hydrate Theory (MRH-Theory): three-dimensional PC validation

NASA Astrophysics Data System (ADS)

Kadyshevich, E. A.; Dzyabchenko, A. V.; Ostrovskii, V. E.

2014-04-01

Size compatibility of the CH4-hydrate structure II and multi-component DNA fragments is confirmed by three-dimensional simulation; it is validation of the Life Origination Hydrate Theory (LOH-Theory).

A THREE-DIMENSIONAL MODEL ASSESSMENT OF THE GLOBAL DISTRIBUTION OF HEXACHLOROBENZENE

EPA Science Inventory

The distributions of persistent organic pollutants (POPs) in the global environment have been studied typically with box/fugacity models with simplified treatments of atmospheric transport processes1. Such models are incapable of simulating the complex three-dimensional mechanis...

A teleoperation training simulator with visual and kinesthetic force virtual reality

NASA Technical Reports Server (NTRS)

Kim, Won S.; Schenker, Paul

1992-01-01

A force-reflecting teleoperation training simulator with a high-fidelity real-time graphics display has been developed for operator training. A novel feature of this simulator is that it enables the operator to feel contact forces and torques through a force-reflecting controller during the execution of the simulated peg-in-hole task, providing the operator with the feel of visual and kinesthetic force virtual reality. A peg-in-hole task is used in our simulated teleoperation trainer as a generic teleoperation task. A quasi-static analysis of a two-dimensional peg-in-hole task model has been extended to a three-dimensional model analysis to compute contact forces and torques for a virtual realization of kinesthetic force feedback. The simulator allows the user to specify force reflection gains and stiffness (compliance) values of the manipulator hand for both the three translational and the three rotational axes in Cartesian space. Three viewing modes are provided for graphics display: single view, two split views, and stereoscopic view.

Reflection Matrix for Optical Resonators in FEL (Free Electron Lasers) Oscillators

DTIC Science & Technology

1988-09-22

is the dominant factor determining the reflction coefficient. The effects of deflecting tho’ light beam enter as small corrections, of first order in...RESONATORS IN FEL OSCILLATORS I. INTRODUCTION 1-7 Free Electron Lasers (FEL) operating as oscillators require the 8-10 trapping of light pulses between...The simplest oscillator configuration is that of an open resonator with two opposed identical mirrors. The radiation vector potential for this

Vibrational Analysis of a Shipboard Free Electron Laser Beam Path

DTIC Science & Technology

2011-12-01

2 Figure 2. Optical Extraction (η) vs. Separation and Electron Beam Tilt for a Notional FEL Oscillator . (From [1...in Figure 2. Figure 2. Optical Extraction (η) vs. Separation and Electron Beam Tilt for a Notional FEL Oscillator . (From [1]) The narrow beam...3 is a top down view of the entire electron beam path. Figure 3. Electron Beam Line of a Notional FEL Oscillator . 2. Optical Path The optical

Quality of Expert Systems: Methods and Techniques (Kwaliteit van Expertsystemen: Methoden en Technieken)

DTIC Science & Technology

1989-12-01

en Elektroniscb Laboratorium TNO (FEL-TNO), de Rijksuniversiteit Limburg (RL) en bet Research Instituut voor Kennis-Systemen (RIKS). In dit rapport...kwaliteitsbeheersing van kennissystemen. TNO rapport Pagina 2 report no : FEL-89-A267 bee Quality of Expert Systems: Methods and Techniques author(s) J.H.J. Lenting MA...Defence Research and Development. Participants in the project are TNO Physics and Electronics Laboratory (FEL-TNO), University of Limburg (RL) and

Use of the CEBAF Accelerator for IR and UV Free Electron Lasers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yunn, Byung; Sinclair, Charles; Leemann, Christoph

1992-08-01

The CEBAF superconducting linac is capable of accelerating electron beams suitable for driving high-power free-electron lasers. The 45 MeV injector linac with a 6 cm period wiggler can produce kilowatt output powers of infrared light (3.6-17 micrometer), while the 400 MeV north linac can produce ultraviolet light (~200 nm) at similar powers. The FELs require the addition of a high-peak intensity electron source (~ 60 A peak current) and extraction beam lines to wigglers with appropriate electron and photon optics. FEL operation is compatible with simultaneous baseline CEBAF nuclear physics operation. A design for a CEBAF-based FEL facility has beenmore » developed. The current status of the FEL project is reported.« less

Three-Dimensional Liver Surgery Simulation: Computer-Assisted Surgical Planning with Three-Dimensional Simulation Software and Three-Dimensional Printing^.

PubMed

Oshiro, Yukio; Ohkohchi, Nobuhiro

2017-06-01

To perform accurate hepatectomy without injury, it is necessary to understand the anatomical relationship among the branches of Glisson's sheath, hepatic veins, and tumor. In Japan, three-dimensional (3D) preoperative simulation for liver surgery is becoming increasingly common, and liver 3D modeling and 3D hepatectomy simulation by 3D analysis software for liver surgery have been covered by universal healthcare insurance since 2012. Herein, we review the history of virtual hepatectomy using computer-assisted surgery (CAS) and our research to date, and we discuss the future prospects of CAS. We have used the SYNAPSE VINCENT medical imaging system (Fujifilm Medical, Tokyo, Japan) for 3D visualization and virtual resection of the liver since 2010. We developed a novel fusion imaging technique combining 3D computed tomography (CT) with magnetic resonance imaging (MRI). The fusion image enables us to easily visualize anatomic relationships among the hepatic arteries, portal veins, bile duct, and tumor in the hepatic hilum. In 2013, we developed an original software, called Liversim, which enables real-time deformation of the liver using physical simulation, and a randomized control trial has recently been conducted to evaluate the use of Liversim and SYNAPSE VINCENT for preoperative simulation and planning. Furthermore, we developed a novel hollow 3D-printed liver model whose surface is covered with frames. This model is useful for safe liver resection, has better visibility, and the production cost is reduced to one-third of a previous model. Preoperative simulation and navigation with CAS in liver resection are expected to help planning and conducting a surgery and surgical education. Thus, a novel CAS system will contribute to not only the performance of reliable hepatectomy but also to surgical education.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, G. H.; Pesaran, A.; Spotnitz, R.

To understand further the thermal abuse behavior of large format Li-ion batteries for automotive applications, the one-dimensional modeling approach formulated by Hatchard et al. was reproduced. Then it was extended to three dimensions so we could consider the geometrical features, which are critical in large cells for automotive applications. The three-dimensional model captures the shapes and dimensions of cell components and the spatial distributions of materials and temperatures, and is used to simulate oven tests, and to determine how a local hot spot can propagate through the cell. In simulations of oven abuse testing of cells with cobalt oxide cathodemore » and graphite anode with standard LiPF6 electrolyte, the three-dimensional model predicts that thermal runaway will occur sooner or later than the lumped model, depending on the size of the cell. The model results showed that smaller cells reject heat faster than larger cells; this may prevent them from going into thermal runaway under identical abuse conditions. In simulations of local hot spots inside a large cylindrical cell, the three-dimensional model predicts that the reactions initially propagate in the azimuthal and longitudinal directions to form a hollow cylinder-shaped reaction zone.« less

Three-dimensional Numerical Simulations of Rayleigh-Taylor Unstable Flames in Type Ia Supernovae

NASA Astrophysics Data System (ADS)

Zingale, M.; Woosley, S. E.; Rendleman, C. A.; Day, M. S.; Bell, J. B.

2005-10-01

Flame instabilities play a dominant role in accelerating the burning front to a large fraction of the speed of sound in a Type Ia supernova. We present a three-dimensional numerical simulation of a Rayleigh-Taylor unstable carbon flame, following its evolution through the transition to turbulence. A low-Mach number hydrodynamics method is used, freeing us from the harsh time step restrictions imposed by sound waves. We fully resolve the thermal structure of the flame and its reaction zone, eliminating the need for a flame model. A single density is considered, 1.5×107 g cm-3, and half-carbon, half-oxygen fuel: conditions under which the flame propagated in the flamelet regime in our related two-dimensional study. We compare to a corresponding two-dimensional simulation and show that while fire polishing keeps the small features suppressed in two dimensions, turbulence wrinkles the flame on far smaller scales in the three-dimensional case, suggesting that the transition to the distributed burning regime occurs at higher densities in three dimensions. Detailed turbulence diagnostics are provided. We show that the turbulence follows a Kolmogorov spectrum and is highly anisotropic on the large scales, with a much larger integral scale in the direction of gravity. Furthermore, we demonstrate that it becomes more isotropic as it cascades down to small scales. On the basis of the turbulent statistics and the flame properties of our simulation, we compute the Gibson scale. We show the progress of the turbulent flame through a classic combustion regime diagram, indicating that the flame just enters the distributed burning regime near the end of our simulation.

[Research progress of three-dimensional digital model for repair and reconstruction of knee joint].

PubMed

Tong, Lu; Li, Yanlin; Hu, Meng

2013-01-01

To review recent advance in the application and research of three-dimensional digital knee model. The recent original articles about three-dimensional digital knee model were extensively reviewed and analyzed. The digital three-dimensional knee model can simulate the knee complex anatomical structure very well. Based on this, there are some developments of new software and techniques, and good clinical results are achieved. With the development of computer techniques and software, the knee repair and reconstruction procedure has been improved, the operation will be more simple and its accuracy will be further improved.

Local Gram-Schmidt and covariant Lyapunov vectors and exponents for three harmonic oscillator problems

NASA Astrophysics Data System (ADS)

Hoover, Wm. G.; Hoover, Carol G.

2012-02-01

We compare the Gram-Schmidt and covariant phase-space-basis-vector descriptions for three time-reversible harmonic oscillator problems, in two, three, and four phase-space dimensions respectively. The two-dimensional problem can be solved analytically. The three-dimensional and four-dimensional problems studied here are simultaneously chaotic, time-reversible, and dissipative. Our treatment is intended to be pedagogical, for use in an updated version of our book on Time Reversibility, Computer Simulation, and Chaos. Comments are very welcome.

Metadynamics in the conformational space nonlinearly dimensionally reduced by Isomap.

PubMed

Spiwok, Vojtěch; Králová, Blanka

2011-12-14

Atomic motions in molecules are not linear. This infers that nonlinear dimensionality reduction methods can outperform linear ones in analysis of collective atomic motions. In addition, nonlinear collective motions can be used as potentially efficient guides for biased simulation techniques. Here we present a simulation with a bias potential acting in the directions of collective motions determined by a nonlinear dimensionality reduction method. Ad hoc generated conformations of trans,trans-1,2,4-trifluorocyclooctane were analyzed by Isomap method to map these 72-dimensional coordinates to three dimensions, as described by Brown and co-workers [J. Chem. Phys. 129, 064118 (2008)]. Metadynamics employing the three-dimensional embeddings as collective variables was applied to explore all relevant conformations of the studied system and to calculate its conformational free energy surface. The method sampled all relevant conformations (boat, boat-chair, and crown) and corresponding transition structures inaccessible by an unbiased simulation. This scheme allows to use essentially any parameter of the system as a collective variable in biased simulations. Moreover, the scheme we used for mapping out-of-sample conformations from the 72D to 3D space can be used as a general purpose mapping for dimensionality reduction, beyond the context of molecular modeling. © 2011 American Institute of Physics

Comparison of two-dimensional and three-dimensional simulations of dense nonaqueous phase liquids (DNAPLs): Migration and entrapment in a nonuniform permeability field

NASA Astrophysics Data System (ADS)

Christ, John A.; Lemke, Lawrence D.; Abriola, Linda M.

2005-01-01

The influence of reduced dimensionality (two-dimensional (2-D) versus 3-D) on predictions of dense nonaqueous phase liquid (DNAPL) infiltration and entrapment in statistically homogeneous, nonuniform permeability fields was investigated using the University of Texas Chemical Compositional Simulator (UTCHEM), a 3-D numerical multiphase simulator. Hysteretic capillary pressure-saturation and relative permeability relationships implemented in UTCHEM were benchmarked against those of another lab-tested simulator, the Michigan-Vertical and Lateral Organic Redistribution (M-VALOR). Simulation of a tetrachloroethene spill in 16 field-scale aquifer realizations generated DNAPL saturation distributions with approximately equivalent distribution metrics in two and three dimensions, with 2-D simulations generally resulting in slightly higher maximum saturations and increased vertical spreading. Variability in 2-D and 3-D distribution metrics across the set of realizations was shown to be correlated at a significance level of 95-99%. Neither spill volume nor release rate appeared to affect these conclusions. Variability in the permeability field did affect spreading metrics by increasing the horizontal spreading in 3-D more than in 2-D in more heterogeneous media simulations. The assumption of isotropic horizontal spatial statistics resulted, on average, in symmetric 3-D saturation distribution metrics in the horizontal directions. The practical implication of this study is that for statistically homogeneous, nonuniform aquifers, 2-D simulations of saturation distributions are good approximations to those obtained in 3-D. However, additional work will be needed to explore the influence of dimensionality on simulated DNAPL dissolution.

Two- and three-dimensional turbine blade row flow field simulations

NASA Technical Reports Server (NTRS)

Buggeln, R. C.; Briley, W. R.; Mcdonald, H.; Shamroth, S. J.; Weinberg, B. C.

1987-01-01

Work performed in the numerical simulation of turbine passage flows via a Navier-Stokes approach is discussed. Both laminar and turbulent simulations in both two and three dimensions are discussed. An outline of the approach, background, and an overview of the results are given.

Crack Modelling for Radiography

NASA Astrophysics Data System (ADS)

Chady, T.; Napierała, L.

2010-02-01

In this paper, possibility of creation of three-dimensional crack models, both random type and based on real-life radiographic images is discussed. Method for storing cracks in a number of two-dimensional matrices, as well algorithm for their reconstruction into three-dimensional objects is presented. Also the possibility of using iterative algorithm for matching simulated images of cracks to real-life radiographic images is discussed.

Three-dimensional numerical study of heat transfer enhancement in separated flows

NASA Astrophysics Data System (ADS)

Kumar, Saurav; Vengadesan, S.

2017-11-01

The flow separation appears in a wide range of heat transfer applications and causes poor heat transfer performance. It motivates the study of heat transfer enhancement in laminar as well as turbulent flows over a backward facing step by means of an adiabatic fin mounted on the top wall. Recently, we have studied steady, 2-D numerical simulations in laminar flow and investigated the effect of fin length, location, and orientation. It revealed that the addition of fin causes enhancement of heat transfer and it is very effective to control the flow and thermal behavior. The fin is most effective and sensitive when it is placed exactly above the step. A slight displacement of the fin in upstream of the step causes the complete change of flow and thermal behavior. Based on the obtained 2-D results it is interesting to investigate the side wall effect in three-dimensional simulations. The comparison of two-dimensional and three-dimensional numerical simulations with the available experimental results will be presented. Special attention has to be given to capture unsteadiness in the flow and thermal field.

Direct simulations of chemically reacting turbulent mixing layers, part 2

NASA Technical Reports Server (NTRS)

Metcalfe, Ralph W.; Mcmurtry, Patrick A.; Jou, Wen-Huei; Riley, James J.; Givi, Peyman

1988-01-01

The results of direct numerical simulations of chemically reacting turbulent mixing layers are presented. This is an extension of earlier work to a more detailed study of previous three dimensional simulations of cold reacting flows plus the development, validation, and use of codes to simulate chemically reacting shear layers with heat release. Additional analysis of earlier simulations showed good agreement with self similarity theory and laboratory data. Simulations with a two dimensional code including the effects of heat release showed that the rate of chemical product formation, the thickness of the mixing layer, and the amount of mass entrained into the layer all decrease with increasing rates of heat release. Subsequent three dimensional simulations showed similar behavior, in agreement with laboratory observations. Baroclinic torques and thermal expansion in the mixing layer were found to produce changes in the flame vortex structure that act to diffuse the pairing vortices, resulting in a net reduction in vorticity. Previously unexplained anomalies observed in the mean velocity profiles of reacting jets and mixing layers were shown to result from vorticity generation by baroclinic torques.

Three-dimensional computer simulation of non-reacting jet-gas flow mixing in an MHD second stage combustor

NASA Astrophysics Data System (ADS)

Chang, S. L.; Lottes, S. A.; Berry, G. F.

Argonne National Laboratory is investigating the non-reacting jet-gas mixing patterns in a magnetohydrodynamics (MHD) second stage combustor by using a three-dimensional single-phase hydrodynamics computer program. The computer simulation is intended to enhance the understanding of flow and mixing patterns in the combustor, which in turn may improve downstream MHD channel performance. The code is used to examine the three-dimensional effects of the side walls and the distributed jet flows on the non-reacting jet-gas mixing patterns. The code solves the conservation equations of mass, momentum, and energy, and a transport equation of a turbulence parameter and allows permeable surfaces to be specified for any computational cell.

Three-Dimensional Simulation of Ultrasound-Induced Microalgal Cell Disruption.

PubMed

Wang, M; Yuan, W; Hale, Andy

2016-03-01

The three-dimensional distribution (x, y, and z) of ultrasound-induced microalgal cell disruption in a sonochemical reactor was predicted by solving the Helmholtz equation using a three-dimensional acoustic module in the COMSOL Multiphysics software. The simulated local ultrasound pressure at any given location (x, y, and z) was found to correlate with cell disruption of a freshwater alga, Scenedesmus dimorphus, represented by the change of algal cell particle/debris concentration, chlorophyll-a fluorescence density (CAFD), and Nile red stained lipid fluorescence density (LFD), which was also validated by the model reaction of potassium iodide oxidation (the Weissler reaction). Furthermore, the effect of ultrasound power intensity and processing duration on algal cell disruption was examined to address the limitation of the model.

Inverse energy cascades in three-dimensional turbulence

NASA Technical Reports Server (NTRS)

Hossain, Murshed

1991-01-01

Fully three-dimensional magnetohydrodynamic (MHD) turbulence at large kinetic and low magnetic Reynolds numbers is considered in the presence of a strong uniform magnetic field. It is shown by numerical simulation of a model of MHD that the energy inverse cascades to longer length scales when the interaction parameter is large. While the steady-state dynamics of the driven problem is three-dimensional in character, the behavior has resemblance to two-dimensional hydrodynamics. These results have implications in turbulence theory, MHD power generator, planetary dynamos, and fusion reactor blanket design.

An analytic, approximate method for modeling steady, three-dimensional flow to partially penetrating wells

NASA Astrophysics Data System (ADS)

Bakker, Mark

2001-05-01

An analytic, approximate solution is derived for the modeling of three-dimensional flow to partially penetrating wells. The solution is written in terms of a correction on the solution for a fully penetrating well and is obtained by dividing the aquifer up, locally, in a number of aquifer layers. The resulting system of differential equations is solved by application of the theory for multiaquifer flow. The presented approach has three major benefits. First, the solution may be applied to any groundwater model that can simulate flow to a fully penetrating well; the solution may be superimposed onto the solution for the fully penetrating well to simulate the local three-dimensional drawdown and flow field. Second, the approach is applicable to isotropic, anisotropic, and stratified aquifers and to both confined and unconfined flow. Third, the solution extends over a small area around the well only; outside this area the three-dimensional effect of the partially penetrating well is negligible, and no correction to the fully penetrating well is needed. A number of comparisons are made to existing three-dimensional, analytic solutions, including radial confined and unconfined flow and a well in a uniform flow field. It is shown that a subdivision in three layers is accurate for many practical cases; very accurate solutions are obtained with more layers.

Three-dimensional simulation of vortex breakdown

NASA Technical Reports Server (NTRS)

Kuruvila, G.; Salas, M. D.

1990-01-01

The integral form of the complete, unsteady, compressible, three-dimensional Navier-Stokes equations in the conservation form, cast in generalized coordinate system, are solved, numerically, to simulate the vortex breakdown phenomenon. The inviscid fluxes are discretized using Roe's upwind-biased flux-difference splitting scheme and the viscous fluxes are discretized using central differencing. Time integration is performed using a backward Euler ADI (alternating direction implicit) scheme. A full approximation multigrid is used to accelerate the convergence to steady state.

Rapid Prediction of Unsteady Three-Dimensional Viscous Flows in Turbopump Geometries

NASA Technical Reports Server (NTRS)

Dorney, Daniel J.

1998-01-01

A program is underway to improve the efficiency of a three-dimensional Navier-Stokes code and generalize it for nozzle and turbopump geometries. Code modifications will include the implementation of parallel processing software, incorporating new physical models and generalizing the multi-block capability to allow the simultaneous simulation of nozzle and turbopump configurations. The current report contains details of code modifications, numerical results of several flow simulations and the status of the parallelization effort.

Environmental, Transient, Three-Dimensional, Hydrothermal, Mass Transport Code - FLESCOT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Onishi, Yasuo; Bao, Jie; Glass, Kevin A.

The purpose of the project was to modify and apply the transient, three-dimensional FLESCOT code to be able to effectively simulate cesium behavior in Fukushima lakes/dam reservoirs, river mouths, and coastal areas. The ultimate objective of the FLESCOT simulation is to predict future changes of cesium accumulation in Fukushima area reservoirs and costal water. These evaluation results will assist ongoing and future environmental remediation activities and policies in a systematic and comprehensive manner.

PROCEEDING OF THE SEEDED X-RAY FREE ELECTRON LASER WORKSHOP.

DOE Office of Scientific and Technical Information (OSTI.GOV)

WANG,X.J.; MURPHY,J.B.; YU,L.H.

2002-12-13

The underlying theory of a high gain free electron laser (FEL) has existed for two decades [1-2], but it is only in the last few years that these novel radiation sources have been realized experimentally. Several high gain FELs have successfully reached saturation in the infrared, visible and the VUV portion of the spectrum: the High Gain Harmonic Generation (HGHG) free electron lasers [3] at BNL and the Self Amplified Spontaneous Emission (SASE) FELs at LEUTL, VISA and TTF [4-6]. The outstanding challenges for future FELs are to extend high gain FELs to the X-ray regime, improve the longitudinal coherencemore » of the radiation using seeded FEL schemes and generate ultrashort pulses (<100 fs). The National Synchrotron Light Source (NSLS) of the Brookhaven National Laboratory (BNL) sponsored a Seeded X-ray Free Electron Laser Workshop on December 13-14, 2002 to explore these challenging issues. Representatives from BNL, DESY, LBNL, SLAC and UCLA made presentations on the novel schemes under consideration at their laboratories. Workshop participants had a lively discussion on the feasibility, performance and R&D issues associated with the seeded XFEL schemes. An improvement of the electron beam quality will certainly be necessary to drive the XFEL. Self-seeding SASE, cascaded HGHG, and SASE pulse compression FELs show the most promise for producing short pulse X-rays. Of these, only the self-seeded and HGHG schemes generate longitudinally coherent radiation. While the pulse length in the self-seeded scheme is determined by the electron bunch length ({approx}100 fs), the pulse length in the HGHG scheme is determined by the short pulse seed laser, and so can be much shorter ({approx} 20 fs).« less

First results from the commissioning of the FERMI@Elettra free electron laser by means of the Photon Analysis Delivery and Reduction System (PADReS)

NASA Astrophysics Data System (ADS)

Zangrando, M.; Cudin, I.; Fava, C.; Gerusina, S.; Gobessi, R.; Godnig, R.; Rumiz, L.; Svetina, C.; Parmigiani, F.; Cocco, D.

2011-06-01

The Italian Free Electron Laser (FEL) facility FERMI@Elettra has started to produce photon radiation at the end of 2010. The photon beam is presently delivered by the first undulator chain (FEL1) that is supposed to produce photons in the 100-20 nm wavelength range. A second undulator chain (FEL2) will be commissioned at the end of 2011, and it will produce radiation in the 20-4nm range. The Photon Analysis Delivery and Reduction System (PADReS) was designed to collect the radiation coming from both the undulator chains (FEL1 and FEL2), to characterize and control it, and to redirect it towards the following beamlines. The first parameters that are checked are the pulse-resolved intensity and beam position. For each of these parameters two dedicated monitors are installed along PADReS on each FEL line. In this way it possible to determine the intensity reduction that is realized by the gas reduction system, which is capable of cutting the intensity by up to four orders of magnitude. The energy distribution of each single pulse is characterized by an online spectrometer installed in the experimental hall. Taking advantage of a variable line-spacing grating it can direct the almost-full beam to the beamlines, while it uses a small fraction of the beam itself to determine the spectral distribution of each pulse delivered by the FEL. The first light of FERMI@Elettra, delivered to the PADReS section in late 2010, is used for the first commissioning runs and some preliminary experiments whose results are reported and discussed in detail.

A Three-Dimensional Finite-Element Model for Simulating Water Flow in Variably Saturated Porous Media

NASA Astrophysics Data System (ADS)

Huyakorn, Peter S.; Springer, Everett P.; Guvanasen, Varut; Wadsworth, Terry D.

1986-12-01

A three-dimensional finite-element model for simulating water flow in variably saturated porous media is presented. The model formulation is general and capable of accommodating complex boundary conditions associated with seepage faces and infiltration or evaporation on the soil surface. Included in this formulation is an improved Picard algorithm designed to cope with severely nonlinear soil moisture relations. The algorithm is formulated for both rectangular and triangular prism elements. The element matrices are evaluated using an "influence coefficient" technique that avoids costly numerical integration. Spatial discretization of a three-dimensional region is performed using a vertical slicing approach designed to accommodate complex geometry with irregular boundaries, layering, and/or lateral discontinuities. Matrix solution is achieved using a slice successive overrelaxation scheme that permits a fairly large number of nodal unknowns (on the order of several thousand) to be handled efficiently on small minicomputers. Six examples are presented to verify and demonstrate the utility of the proposed finite-element model. The first four examples concern one- and two-dimensional flow problems used as sample problems to benchmark the code. The remaining examples concern three-dimensional problems. These problems are used to illustrate the performance of the proposed algorithm in three-dimensional situations involving seepage faces and anisotropic soil media.

Evaluation of irradiation effects of near-infrared free-electron-laser of silver alloy for dental application.

PubMed

Kuwada-Kusunose, Takao; Kusunose, Alisa; Wakami, Masanobu; Takebayashi, Chikako; Goto, Haruhiko; Aida, Masahiro; Sakai, Takeshi; Nakao, Keisuke; Nogami, Kyoko; Inagaki, Manabu; Hayakawa, Ken; Suzuki, Kunihiro; Sakae, Toshiro

2017-08-01

In the application of lasers in dentistry, there is a delicate balance between the benefits gained from laser treatment and the heat-related damage arising from laser irradiation. Hence, it is necessary to understand the different processes associated with the irradiation of lasers on dental materials. To obtain insight for the development of a safe and general-purpose laser for dentistry, the present study examines the physical effects associated with the irradiation of a near-infrared free-electron laser (FEL) on the surface of a commonly used silver dental alloy. The irradiation experiments using a 2900-nm FEL confirmed the formation of a pit in the dental alloy. The pit was formed with one macro-pulse of FEL irradiation, therefore, suggesting the possibility of efficient material processing with an FEL. Additionally, there was only a slight increase in the silver alloy temperature (less than 0.9 °C) despite the long duration of FEL irradiation, thus inferring that fixed prostheses in the oral cavity can be processed by FEL without thermal damage to the surrounding tissue. These results indicate that dental hard tissues and dental materials in the oral cavity can be safely and efficiently processed by the irradiation of a laser, which has the high repetition rate of a femtosecond laser pulse with a wavelength around 2900 nm.

Three Dimensional Thermal Pollution Models. Volume 2; Rigid-Lid Models

NASA Technical Reports Server (NTRS)

Lee, S. S.; Sengupta, S.

1978-01-01

Three versions of rigid lid programs are presented: one for near field simulation; the second for far field unstratified situations; and the third for stratified basins, far field simulation. The near field simulates thermal plume areas, and the far field version simulates larger receiving aquatic ecosystems. Since these versions have many common subroutines, a unified testing is provided, with main programs for the three possible conditions listed.

Towards an Automated Full-Turbofan Engine Numerical Simulation

NASA Technical Reports Server (NTRS)

Reed, John A.; Turner, Mark G.; Norris, Andrew; Veres, Joseph P.

2003-01-01

The objective of this study was to demonstrate the high-fidelity numerical simulation of a modern high-bypass turbofan engine. The simulation utilizes the Numerical Propulsion System Simulation (NPSS) thermodynamic cycle modeling system coupled to a high-fidelity full-engine model represented by a set of coupled three-dimensional computational fluid dynamic (CFD) component models. Boundary conditions from the balanced, steady-state cycle model are used to define component boundary conditions in the full-engine model. Operating characteristics of the three-dimensional component models are integrated into the cycle model via partial performance maps generated automatically from the CFD flow solutions using one-dimensional meanline turbomachinery programs. This paper reports on the progress made towards the full-engine simulation of the GE90-94B engine, highlighting the generation of the high-pressure compressor partial performance map. The ongoing work will provide a system to evaluate the steady and unsteady aerodynamic and mechanical interactions between engine components at design and off-design operating conditions.

Experimental setups for FEL-based four-wave mixing experiments at FERMI

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bencivenga, Filippo; Zangrando, Marco; Svetina, Cristian

2016-01-01

The recent advent of free-electron laser (FEL) sources is driving the scientific community to extend table-top laser research to shorter wavelengths adding elemental selectivity and chemical state specificity. Both a compact setup (mini-TIMER) and a separate instrument (EIS-TIMER) dedicated to four-wave-mixing (FWM) experiments has been designed and constructed, to be operated as a branch of the Elastic and Inelastic Scattering beamline: EIS. The FWM experiments that are planned at EIS-TIMER are based on the transient grating approach, where two crossed FEL pulses create a controlled modulation of the sample excitations while a third time-delayed pulse is used to monitor themore » dynamics of the excited state. This manuscript describes such experimental facilities, showing the preliminary results of the commissioning of the EIS-TIMER beamline, and discusses original experimental strategies being developed to study the dynamics of matter at the fs–nm time–length scales. In the near future such experimental tools will allow more sophisticated FEL-based FWM applications, that also include the use of multiple and multi-color FEL pulses.« less

Experimental setups for FEL-based four-wave mixing experiments at FERMI

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bencivenga, Filippo; Zangrando, Marco; Svetina, Cristian

The recent advent of free-electron laser (FEL) sources is driving the scientific community to extend table-top laser research to shorter wavelengths adding elemental selectivity and chemical state specificity. Both a compact setup (mini-TIMER) and a separate instrument (EIS-TIMER) dedicated to four-wave-mixing (FWM) experiments has been designed and constructed, to be operated as a branch of the Elastic and Inelastic Scattering beamline: EIS. The FWM experiments that are planned at EIS-TIMER are based on the transient grating approach, where two crossed FEL pulses create a controlled modulation of the sample excitations while a third time-delayed pulse is used to monitor themore » dynamics of the excited state. This manuscript describes such experimental facilities, showing the preliminary results of the commissioning of the EIS-TIMER beamline, and discusses original experimental strategies being developed to study the dynamics of matter at the fs–nm time–length scales. In the near future such experimental tools will allow more sophisticated FEL-based FWM applications, that also include the use of multiple and multi-color FEL pulses.« less

A THREE-DIMENSIONAL AIR FLOW MODEL FOR SOIL VENTING: SUPERPOSITION OF ANLAYTICAL FUNCTIONS

EPA Science Inventory

A three-dimensional computer model was developed for the simulation of the soil-air pressure distribution at steady state and specific discharge vectors during soil venting with multiple wells in unsaturated soil. The Kirchhoff transformation of dependent variables and coordinate...

CONTAMINANT TRANSPORT RESULTING FROM MULTICOMPONENT NONAQUEOUS PHASE LIQUID POOL DISSOLUTION IN THREE-DIMENSIONAL SUBSURFACE FORMATIONS (R823579)

EPA Science Inventory

A semi-analytical method for simulating transient contaminant transport originating from the dissolution of multicomponent nonaqueous phase liquid (NAPL) pools in three-dimensional, saturated, homogeneous porous media is presented. Each dissolved component may undergo first-order...

An Energy Model of Place Cell Network in Three Dimensional Space.

PubMed

Wang, Yihong; Xu, Xuying; Wang, Rubin

2018-01-01

Place cells are important elements in the spatial representation system of the brain. A considerable amount of experimental data and classical models are achieved in this area. However, an important question has not been addressed, which is how the three dimensional space is represented by the place cells. This question is preliminarily surveyed by energy coding method in this research. Energy coding method argues that neural information can be expressed by neural energy and it is convenient to model and compute for neural systems due to the global and linearly addable properties of neural energy. Nevertheless, the models of functional neural networks based on energy coding method have not been established. In this work, we construct a place cell network model to represent three dimensional space on an energy level. Then we define the place field and place field center and test the locating performance in three dimensional space. The results imply that the model successfully simulates the basic properties of place cells. The individual place cell obtains unique spatial selectivity. The place fields in three dimensional space vary in size and energy consumption. Furthermore, the locating error is limited to a certain level and the simulated place field agrees to the experimental results. In conclusion, this is an effective model to represent three dimensional space by energy method. The research verifies the energy efficiency principle of the brain during the neural coding for three dimensional spatial information. It is the first step to complete the three dimensional spatial representing system of the brain, and helps us further understand how the energy efficiency principle directs the locating, navigating, and path planning function of the brain.

Future of ePix detectors for high repetition rate FELs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blaj, G., E-mail: blaj@slac.stanford.edu; Caragiulo, P.; Carini, G.

2016-07-27

Free-electron lasers (FELs) made the imaging of atoms and molecules in motion possible, opening new science opportunities with high brilliance, ultra-short x-ray laser pulses at up to 120 Hz. Some new or upgraded FEL facilities will operate at greatly increased pulse rates (kHz to MHz), presenting additional requirements on detection. We will present the ePix platform for x-ray detectors and the current status of the ePix detectors: ePix100 for low noise applications, ePix10k for high dynamic range applications, and ePixS for spectroscopic applications. Then we will introduce the plans to match the ePix detectors with the requirements of currently plannedmore » high repetition rate FELs (mainly readout speed and energy range).« less

The photon beam transport and diagnostics system at FERMI@Elettra, the Italian seeded FEL source: commissioning experience and most recent results

NASA Astrophysics Data System (ADS)

Zangrando, Marco; Abrami, Alessandro; Cocco, Daniele; Fava, Claudio; Gerusina, Simone; Gobessi, Riccardo; Mahne, Nicola; Mazzucco, Eric; Raimondi, Lorenzo; Rumiz, Luca; Svetina, Cristian; Parmigiani, Fulvio

2012-10-01

FERMI@Elettra, the Italian Free Electron Laser (FEL) source, is in an advanced commissioning phase, having already delivered radiation down to the endstations. The facility is routinely using the low energy branch (FEL1) to produce photons in the 65-20 nm range, while the 20-4 nm range will be covered by FEL2 that is now being commissioned. A dedicated system to collect, diagnose, transport and focus the radiation (PADReS) is used to provide informations about the photon beam intensity, position, spectral content, transverse coherence, and so on. The experience gathered so far, as well as the most recent results both from the diagnostic section and the beam manipulation part are presented here.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Savelyev, Evgeny; Boll, Rebecca; Bomme, Cedric

In pump-probe experiments employing a free-electron laser (FEL) in combination with a synchronized optical femtosecond laser, the arrival-time jitter between the FEL pulse and the optical laser pulse often severely limits the temporal resolution that can be achieved. Here, we present a pump-probe experiment on the UV-induced dissociation of 2,6-difluoroiodobenzene C 6H 3F 2I) molecules performed at the FLASH FEL that takes advantage of recent upgrades of the FLASH timing and synchronization system to obtain high-quality data that are not limited by the FEL arrival-time jitter. Here, we discuss in detail the necessary data analysis steps and describe the originmore » of the time-dependent effects in the yields and kinetic energies of the fragment ions that we observe in the experiment.« less

A high-average-power FEL for industrial applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dylla, H.F.; Benson, S.; Bisognano, J.

1995-12-31

CEBAF has developed a comprehensive conceptual design of an industrial user facility based on a kilowatt UV (150-1000 nm) and IR (2-25 micron) FEL driven by a recirculating, energy-recovering 200 MeV superconducting radio-frequency (SRF) accelerator. FEL users{endash}CEBAF`s partners in the Laser Processing Consortium, including AT&T, DuPont, IBM, Northrop-Grumman, 3M, and Xerox{endash}plan to develop applications such as polymer surface processing, metals and ceramics micromachining, and metal surface processing, with the overall effort leading to later scale-up to industrial systems at 50-100 kW. Representative applications are described. The proposed high-average-power FEL overcomes limitations of conventional laser sources in available power, cost-effectiveness, tunabilitymore » and pulse structure. 4 refs., 3 figs., 2 tabs.« less

Soft X-ray FEL simulation in PAL-XFEL

NASA Astrophysics Data System (ADS)

Shim, Chi Hyun; Ko, In Soo; Parc, Yong Woon; Han, Jang Hui

2015-10-01

The soft X-ray beamline in the Pohang Accelerator Laboratory X-ray Free Electron Laser (PAL-XFEL) will provide a photon beam with a wavelength from 1 nm to 3 nm in the self-amplified spontaneous emission (SASE) mode by using an electron beam with a 3.15-GeV beam energy. Linearly polarized radiation will be supplied by using six planar undulators (PUs). The linearly-polarized radiation powers at 1 (3) nm can reach 10.2 (30) GW. Polarization of the radiation will be controlled by applying the reverse undulator tapering scheme to the PUs and adding two helical undulators (HUs). The circularly-polarized radiation powers at 1 (3) nm will be 3.11 (11.73) GW. The degrees of circular polarization will be larger than 0.99 for both wavelengths. Three options for the future upgrade of the beamline to increase the radiation power are proposed.

A smoothed particle hydrodynamics model for miscible flow in three-dimensional fractures and the two-dimensional Rayleigh–Taylor instability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tartakovsky, Alexandre M.; Meakin, Paul

2005-08-10

A numerical model based on smoothed particle hydrodynamics (SPH) has been developed and used to simulate the classical two-dimensional Rayleigh–Taylor instability and three-dimensional miscible flow in fracture apertures with complex geometries. To model miscible flow fluid particles with variable, composition dependent, masses were used. By basing the SPH equations on the particle number density artificial surface tension effects were avoided. The simulation results for the growth of a single perturbation driven by the Rayleigh – Taylor instability compare well with numerical results obtained by Fournier et al., and the growth of a perturbation with time can be represented quite wellmore » by a second-degree polynomial, in accord with the linear stability analysis of Duff et al. The dispersion coefficient found from SPH simulation of flow and diffusion in an ideal fracture was in excellent agreement with the value predicted by the theory of Taylor and Aris. The simulations of miscible flow in fracture apertures can be used to determination dispersion coefficients for transport in fractured media - a parameter used in large-scale simulations of contaminant transport.« less

Three-dimensional simulation of triode-type MIG for 1 MW, 120 GHz gyrotron for ECRH applications

NASA Astrophysics Data System (ADS)

Singh, Udaybir; Kumar, Nitin; Kumar, Narendra; Kumar, Anil; Sinha, A. K.

2012-01-01

In this paper, the three-dimensional simulation of triode-type magnetron injection gun (MIG) for 120 GHz, 1 MW gyrotron is presented. The operating voltages of the modulating anode and the accelerating anode are 57 kV and 80 kV respectively. The high order TE 22,6 mode is selected as the operating mode and the electron beam is launched at the first radial maxima for the fundamental beam-mode operation. The initial design is obtained by using the in-house developed code MIGSYN. The numerical simulation is performed by using the commercially available code CST-Particle Studio (PS). The simulated results of MIG obtained by using CST-PS are validated with other simulation codes EGUN and TRAK, respectively. The results on the design output parameters obtained by using these three codes are found to be in close agreement.

Three-dimensional whispering gallery modes in InGaAs nanoneedle lasers on silicon

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tran, T.-T. D.; Chen, R.; Ng, K. W.

2014-09-15

As-grown InGaAs nanoneedle lasers, synthesized at complementary metal–oxide–semiconductor compatible temperatures on polycrystalline and crystalline silicon substrates, were studied in photoluminescence experiments. Radiation patterns of three-dimensional whispering gallery modes were observed upon optically pumping the needles above the lasing threshold. Using the radiation patterns as well as finite-difference-time-domain simulations and polarization measurements, all modal numbers of the three-dimensional whispering gallery modes could be identified.

Analysis of spatial thermal field in a magnetic bearing

NASA Astrophysics Data System (ADS)

Wajnert, Dawid; Tomczuk, Bronisław

2018-03-01

This paper presents two mathematical models for temperature field analysis in a new hybrid magnetic bearing. Temperature distributions have been calculated using a three dimensional simulation and a two dimensional one. A physical model for temperature testing in the magnetic bearing has been developed. Some results obtained from computer simulations were compared with measurements.

Wave propagation simulation in the upper core of sodium-cooled fast reactors using a spectral-element method for heterogeneous media

NASA Astrophysics Data System (ADS)

Nagaso, Masaru; Komatitsch, Dimitri; Moysan, Joseph; Lhuillier, Christian

2018-01-01

ASTRID project, French sodium cooled nuclear reactor of 4th generation, is under development at the moment by Alternative Energies and Atomic Energy Commission (CEA). In this project, development of monitoring techniques for a nuclear reactor during operation are identified as a measure issue for enlarging the plant safety. Use of ultrasonic measurement techniques (e.g. thermometry, visualization of internal objects) are regarded as powerful inspection tools of sodium cooled fast reactors (SFR) including ASTRID due to opacity of liquid sodium. In side of a sodium cooling circuit, heterogeneity of medium occurs because of complex flow state especially in its operation and then the effects of this heterogeneity on an acoustic propagation is not negligible. Thus, it is necessary to carry out verification experiments for developments of component technologies, while such kind of experiments using liquid sodium may be relatively large-scale experiments. This is why numerical simulation methods are essential for preceding real experiments or filling up the limited number of experimental results. Though various numerical methods have been applied for a wave propagation in liquid sodium, we still do not have a method for verifying on three-dimensional heterogeneity. Moreover, in side of a reactor core being a complex acousto-elastic coupled region, it has also been difficult to simulate such problems with conventional methods. The objective of this study is to solve these 2 points by applying three-dimensional spectral element method. In this paper, our initial results on three-dimensional simulation study on heterogeneous medium (the first point) are shown. For heterogeneity of liquid sodium to be considered, four-dimensional temperature field (three spatial and one temporal dimension) calculated by computational fluid dynamics (CFD) with Large-Eddy Simulation was applied instead of using conventional method (i.e. Gaussian Random field). This three-dimensional numerical experiment yields that we could verify the effects of heterogeneity of propagation medium on waves in Liquid sodium.

The Effect of Part-simulation of Weightlessness on Human Control of Bilateral Teleoperation: Neuromotor Considerations

NASA Technical Reports Server (NTRS)

Corker, K.; Bejczy, A. K.

1984-01-01

The effect of weightlessness on the human operator's performance in force reflecting position control of remote manipulators was investigated. A gravity compensation system was developed to simulate the effect of weightlessness on the operator's arm. A universal force reflecting hand controller (FRHC) and task simulation software were employed. Two experiments were performed because of anticipated disturbances in neuromotor control specification on the human operator in an orbital control environment to investigate: (1) the effect of controller stiffness on the attainment of a learned terminal position in the three dimensional controller space, and (2) the effect of controller stiffness and damping on force tracking of the contour of a simulated three dimensional cube using the part simulation of weightless conditions. The results support the extension of neuromotor control models, which postulate a stiffness balance encoding of terminal position, to three dimensional motion of a multilink system, confirm the existence of a disturbance in human manual control performance under gravity compensated conditions, and suggest techniques for compensation of weightlessness induced performance decrement through appropriate specification of hand controller response characteristics. These techniques are based on the human control model.

Vectorization of a particle simulation method for hypersonic rarefied flow

NASA Technical Reports Server (NTRS)

Mcdonald, Jeffrey D.; Baganoff, Donald

1988-01-01

An efficient particle simulation technique for hypersonic rarefied flows is presented at an algorithmic and implementation level. The implementation is for a vector computer architecture, specifically the Cray-2. The method models an ideal diatomic Maxwell molecule with three translational and two rotational degrees of freedom. Algorithms are designed specifically for compatibility with fine grain parallelism by reducing the number of data dependencies in the computation. By insisting on this compatibility, the method is capable of performing simulation on a much larger scale than previously possible. A two-dimensional simulation of supersonic flow over a wedge is carried out for the near-continuum limit where the gas is in equilibrium and the ideal solution can be used as a check on the accuracy of the gas model employed in the method. Also, a three-dimensional, Mach 8, rarefied flow about a finite-span flat plate at a 45 degree angle of attack was simulated. It utilized over 10 to the 7th particles carried through 400 discrete time steps in less than one hour of Cray-2 CPU time. This problem was chosen to exhibit the capability of the method in handling a large number of particles and a true three-dimensional geometry.

[3D Virtual Reality Laparoscopic Simulation in Surgical Education - Results of a Pilot Study].

PubMed

Kneist, W; Huber, T; Paschold, M; Lang, H

2016-06-01

The use of three-dimensional imaging in laparoscopy is a growing issue and has led to 3D systems in laparoscopic simulation. Studies on box trainers have shown differing results concerning the benefit of 3D imaging. There are currently no studies analysing 3D imaging in virtual reality laparoscopy (VRL). Five surgical fellows, 10 surgical residents and 29 undergraduate medical students performed abstract and procedural tasks on a VRL simulator using conventional 2D and 3D imaging in a randomised order. No significant differences between the two imaging systems were shown for students or medical professionals. Participants who preferred three-dimensional imaging showed significantly better results in 2D as wells as in 3D imaging. First results on three-dimensional imaging on box trainers showed different results. Some studies resulted in an advantage of 3D imaging for laparoscopic novices. This study did not confirm the superiority of 3D imaging over conventional 2D imaging in a VRL simulator. In the present study on 3D imaging on a VRL simulator there was no significant advantage for 3D imaging compared to conventional 2D imaging. Georg Thieme Verlag KG Stuttgart · New York.

Regions of Stability of FEL Oscillators,

DTIC Science & Technology

1987-10-01

EGION5 OF STABILITY OF FEL OCCILLATORS(U) MARYLAND 1/1 UNIV COLLEGE PARK LAB FOR PLASMA AND FUSION ENERGY STUDIES B LEVUSH ET AL OCT 87 UNLPF-88...MARYLAND j LABRATRY ORPLASMA AND FUSION ENERGY . STUDIES...:’ COLLEGE PARK, MARYLANI) ’ 20742- a 0.6.3 ~0 DT!C IlELEcTEI REGIONS OF STABILITY OF FEL...University of Maryland, Laboratory for Plasma and Fusion Energy Studies ~IT~UTION ST TEMEN Approved iom public :elOOS61=D triution Unli __e REGIONS OF

Efficiency Optimization for FEL Oscillators,

DTIC Science & Technology

1987-12-01

I 7 -ŕvle 3IIATIONCIFOR FEL OSCILLATORS(U) MARYLAND i/1’ UNIV COLLEGE PARK LAS FOR PLASMIA AND FUSION ENERGY STUDIES A SERBETO ET AL DEC 87 UMLPF-88...University of Maryland, By3 f *O- 0Laboratory for Plasrra and Fusion Energy Studies D i~ Avciil adi r "UnOUIO SAEMNT A APPrOVed for public reloe...Distribution Unlimited EFFICIENCY OPTIMIZATION FOR FEL OSCILLATORS A. Serbeto, B. Levush, and T. M. Antonsen, Jr. Laboratory for Plasma and Fusion Energy Studies

Effects of Turbulence Model and Numerical Time Steps on Von Karman Flow Behavior and Drag Accuracy of Circular Cylinder

NASA Astrophysics Data System (ADS)

Amalia, E.; Moelyadi, M. A.; Ihsan, M.

2018-04-01

The flow of air passing around a circular cylinder on the Reynolds number of 250,000 is to show Von Karman Vortex Street Phenomenon. This phenomenon was captured well by using a right turbulence model. In this study, some turbulence models available in software ANSYS Fluent 16.0 was tested to simulate Von Karman vortex street phenomenon, namely k- epsilon, SST k-omega and Reynolds Stress, Detached Eddy Simulation (DES), and Large Eddy Simulation (LES). In addition, it was examined the effect of time step size on the accuracy of CFD simulation. The simulations are carried out by using two-dimensional and three- dimensional models and then compared with experimental data. For two-dimensional model, Von Karman Vortex Street phenomenon was captured successfully by using the SST k-omega turbulence model. As for the three-dimensional model, Von Karman Vortex Street phenomenon was captured by using Reynolds Stress Turbulence Model. The time step size value affects the smoothness quality of curves of drag coefficient over time, as well as affecting the running time of the simulation. The smaller time step size, the better inherent drag coefficient curves produced. Smaller time step size also gives faster computation time.

A 2.5D Computational Method to Simulate Cylindrical Fluidized Beds

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Tingwen; Benyahia, Sofiane; Dietiker, Jeff

2015-02-17

In this paper, the limitations of axisymmetric and Cartesian two-dimensional (2D) simulations of cylindrical gas-solid fluidized beds are discussed. A new method has been proposed to carry out pseudo-two-dimensional (2.5D) simulations of a cylindrical fluidized bed by appropriately combining computational domains of Cartesian 2D and axisymmetric simulations. The proposed method was implemented in the open-source code MFIX and applied to the simulation of a lab-scale bubbling fluidized bed with necessary sensitivity study. After a careful grid study to ensure the numerical results are grid independent, detailed comparisons of the flow hydrodynamics were presented against axisymmetric and Cartesian 2D simulations. Furthermore,more » the 2.5D simulation results have been compared to the three-dimensional (3D) simulation for evaluation. This new approach yields better agreement with the 3D simulation results than with axisymmetric and Cartesian 2D simulations.« less

MODELING THREE-DIMENSIONAL SUBSURFACE FLOW, FATE AND TRANSPORT OF MICROBES AND CHEMICALS (3DFATMIC)

EPA Science Inventory

A three-dimensional model simulating the subsurface flow, microbial growth and degradation, microbial-chemical reaction, and transport of microbes and chemicals has been developed. he model is designed to solve the coupled flow and transport equations. asically, the saturated-uns...

Error-growth dynamics and predictability of surface thermally induced atmospheric flow

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zeng, X.; Pielke, R.A.

1993-09-01

Using the CSU Regional Atmospheric Modeling System (RAMS) in its nonhydrostatic and compressible configuration, over 200 two-dimensional simulations with [Delta]x = 2 km and [Delta]x = 100 m are performed to study in detail the initial adjustment process and the error-growth dynamics of surface thermally induced circulation including the sensitivity to initial conditions, boundary conditions, and model parameters, and to study the predictability as a function of the size of surface heat patches under a calm mean wind. It is found that the error growth is not sensitive to the characterisitics of the initial perturbations. The numerical smoothing has amore » strong impact on the initial adjustment process and on the error-growth dynamics. The predictability and flow structures, it is found that the vertical velocity field is strongly affected by the mean wind, and the flow structures are quite sensitive to the initial soil water content. The transition from organized flow to the situation in which fluxes are dominated by noncoherent turbulent eddies under a calm mean wind is quantitatively evaluated and this transition is different for different variables. The relationship between the predictability of a realization and of an ensemble average is discussed. The predictability and the coherent circulations modulated by the surface inhomogeneities are also studied by computing the autocorrelations and the power spectra. The three-dimensional mesoscale and large-eddy simulations are performed to verify the above results. It is found that the two-dimensional mesoscale (or fine resolution) simulation yields very close or similar results regarding the predictability as those from the three-dimensional mesoscale (or large eddy) simulation. The horizontally averaged quantities based on two-dimensional fine-resolution simulations are insensitive to initial perturbations and agree with those based on three-dimensional large-eddy simulations. 87 refs., 25 figs.« less

Field scale test of multi-dimensional flow and morphodynamic simulations used for restoration design analysis

USGS Publications Warehouse

McDonald, Richard R.; Nelson, Jonathan M.; Fosness, Ryan L.; Nelson, Peter O.; Constantinescu, George; Garcia, Marcelo H.; Hanes, Dan

2016-01-01

Two- and three-dimensional morphodynamic simulations are becoming common in studies of channel form and process. The performance of these simulations are often validated against measurements from laboratory studies. Collecting channel change information in natural settings for model validation is difficult because it can be expensive and under most channel forming flows the resulting channel change is generally small. Several channel restoration projects designed in part to armor large meanders with several large spurs constructed of wooden piles on the Kootenai River, ID, have resulted in rapid bed elevation change following construction. Monitoring of these restoration projects includes post- restoration (as-built) Digital Elevation Models (DEMs) as well as additional channel surveys following high channel forming flows post-construction. The resulting sequence of measured bathymetry provides excellent validation data for morphodynamic simulations at the reach scale of a real river. In this paper we test the performance a quasi-three-dimensional morphodynamic simulation against the measured elevation change. The resulting simulations predict the pattern of channel change reasonably well but many of the details such as the maximum scour are under predicted.

Two-dimensional dynamics of elasto-inertial turbulence and its role in polymer drag reduction

NASA Astrophysics Data System (ADS)

Sid, S.; Terrapon, V. E.; Dubief, Y.

2018-02-01

The goal of the present study is threefold: (i) to demonstrate the two-dimensional nature of the elasto-inertial instability in elasto-inertial turbulence (EIT), (ii) to identify the role of the bidimensional instability in three-dimensional EIT flows, and (iii) to establish the role of the small elastic scales in the mechanism of self-sustained EIT. Direct numerical simulations of viscoelastic fluid flows are performed in both two- and three-dimensional straight periodic channels using the Peterlin finitely extensible nonlinear elastic model (FENE-P). The Reynolds number is set to Reτ=85 , which is subcritical for two-dimensional flows but beyond the transition for three-dimensional ones. The polymer properties selected correspond to those of typical dilute polymer solutions, and two moderate Weissenberg numbers, Wiτ=40 ,100 , are considered. The simulation results show that sustained turbulence can be observed in two-dimensional subcritical flows, confirming the existence of a bidimensional elasto-inertial instability. The same type of instability is also observed in three-dimensional simulations where both Newtonian and elasto-inertial turbulent structures coexist. Depending on the Wi number, one type of structure can dominate and drive the flow. For large Wi values, the elasto-inertial instability tends to prevail over the Newtonian turbulence. This statement is supported by (i) the absence of typical Newtonian near-wall vortices and (ii) strong similarities between two- and three-dimensional flows when considering larger Wi numbers. The role of small elastic scales is investigated by introducing global artificial diffusion (GAD) in the hyperbolic transport equation for polymers. The aim is to measure how the flow reacts when the smallest elastic scales are progressively filtered out. The study results show that the introduction of large polymer diffusion in the system strongly damps a significant part of the elastic scales that are necessary to feed turbulence, eventually leading to flow laminarization. A sufficiently high Schmidt number (weakly diffusive polymers) is necessary to allow self-sustained turbulence to settle. Although EIT can withstand a low amount of diffusion and remains in a nonlaminar chaotic state, adding a finite amount of GAD in the system can have an impact on the dynamics and lead to important quantitative changes, even for Schmidt numbers as large as 102. The use of GAD should therefore be avoided in viscoelastic flow simulations.

A one-dimensional with three-dimensional velocity space hybrid-PIC model of the discharge plasma in a Hall thruster

NASA Astrophysics Data System (ADS)

Shashkov, Andrey; Lovtsov, Alexander; Tomilin, Dmitry

2017-04-01

According to present knowledge, countless numerical simulations of the discharge plasma in Hall thrusters were conducted. However, on the one hand, adequate two-dimensional (2D) models require a lot of time to carry out numerical research of the breathing mode oscillations or the discharge structure. On the other hand, existing one-dimensional (1D) models are usually too simplistic and do not take into consideration such important phenomena as neutral-wall collisions, magnetic field induced by Hall current and double, secondary, and stepwise ionizations together. In this paper a one-dimensional with three-dimensional velocity space (1D3V) hybrid-PIC model is presented. The model is able to incorporate all the phenomena mentioned above. A new method of neutral-wall collisions simulation in described space was developed and validated. Simulation results obtained for KM-88 and KM-60 thrusters are in a good agreement with experimental data. The Bohm collision coefficient was the same for both thrusters. Neutral-wall collisions, doubly charged ions, and induced magnetic field were proved to stabilize the breathing mode oscillations in a Hall thruster under some circumstances.

Numerical simulation on hydromechanical coupling in porous media adopting three-dimensional pore-scale model.

PubMed

Liu, Jianjun; Song, Rui; Cui, Mengmeng

2014-01-01

A novel approach of simulating hydromechanical coupling in pore-scale models of porous media is presented in this paper. Parameters of the sandstone samples, such as the stress-strain curve, Poisson's ratio, and permeability under different pore pressure and confining pressure, are tested in laboratory scale. The micro-CT scanner is employed to scan the samples for three-dimensional images, as input to construct the model. Accordingly, four physical models possessing the same pore and rock matrix characteristics as the natural sandstones are developed. Based on the micro-CT images, the three-dimensional finite element models of both rock matrix and pore space are established by MIMICS and ICEM software platform. Navier-Stokes equation and elastic constitutive equation are used as the mathematical model for simulation. A hydromechanical coupling analysis in pore-scale finite element model of porous media is simulated by ANSYS and CFX software. Hereby, permeability of sandstone samples under different pore pressure and confining pressure has been predicted. The simulation results agree well with the benchmark data. Through reproducing its stress state underground, the prediction accuracy of the porous rock permeability in pore-scale simulation is promoted. Consequently, the effects of pore pressure and confining pressure on permeability are revealed from the microscopic view.

Numerical Simulation on Hydromechanical Coupling in Porous Media Adopting Three-Dimensional Pore-Scale Model

PubMed Central

Liu, Jianjun; Song, Rui; Cui, Mengmeng

2014-01-01

A novel approach of simulating hydromechanical coupling in pore-scale models of porous media is presented in this paper. Parameters of the sandstone samples, such as the stress-strain curve, Poisson's ratio, and permeability under different pore pressure and confining pressure, are tested in laboratory scale. The micro-CT scanner is employed to scan the samples for three-dimensional images, as input to construct the model. Accordingly, four physical models possessing the same pore and rock matrix characteristics as the natural sandstones are developed. Based on the micro-CT images, the three-dimensional finite element models of both rock matrix and pore space are established by MIMICS and ICEM software platform. Navier-Stokes equation and elastic constitutive equation are used as the mathematical model for simulation. A hydromechanical coupling analysis in pore-scale finite element model of porous media is simulated by ANSYS and CFX software. Hereby, permeability of sandstone samples under different pore pressure and confining pressure has been predicted. The simulation results agree well with the benchmark data. Through reproducing its stress state underground, the prediction accuracy of the porous rock permeability in pore-scale simulation is promoted. Consequently, the effects of pore pressure and confining pressure on permeability are revealed from the microscopic view. PMID:24955384

Boundary acquisition for setup of numerical simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Diegert, C.

1997-12-31

The author presents a work flow diagram that includes a path that begins with taking experimental measurements, and ends with obtaining insight from results produced by numerical simulation. Two examples illustrate this path: (1) Three-dimensional imaging measurement at micron scale, using X-ray tomography, provides information on the boundaries of irregularly-shaped alumina oxide particles held in an epoxy matrix. A subsequent numerical simulation predicts the electrical field concentrations that would occur in the observed particle configurations. (2) Three-dimensional imaging measurement at meter scale, again using X-ray tomography, provides information on the boundaries fossilized bone fragments in a Parasaurolophus crest recently discoveredmore » in New Mexico. A subsequent numerical simulation predicts acoustic response of the elaborate internal structure of nasal passageways defined by the fossil record. The author must both add value, and must change the format of the three-dimensional imaging measurements before the define the geometric boundary initial conditions for the automatic mesh generation, and subsequent numerical simulation. The author applies a variety of filters and statistical classification algorithms to estimate the extents of the structures relevant to the subsequent numerical simulation, and capture these extents as faceted geometries. The author will describe the particular combination of manual and automatic methods used in the above two examples.« less

A three-dimensional model to assess the effect of ankle joint axis misalignments in ankle-foot orthoses.

PubMed

Fatone, Stefania; Johnson, William Brett; Tucker, Kerice

2016-04-01

Misalignment of an articulated ankle-foot orthosis joint axis with the anatomic joint axis may lead to discomfort, alterations in gait, and tissue damage. Theoretical, two-dimensional models describe the consequences of misalignments, but cannot capture the three-dimensional behavior of ankle-foot orthosis use. The purpose of this project was to develop a model to describe the effects of ankle-foot orthosis ankle joint misalignment in three dimensions. Computational simulation. Three-dimensional scans of a leg and ankle-foot orthosis were incorporated into a link segment model where the ankle-foot orthosis joint axis could be misaligned with the anatomic ankle joint axis. The leg/ankle-foot orthosis interface was modeled as a network of nodes connected by springs to estimate interface pressure. Motion between the leg and ankle-foot orthosis was calculated as the ankle joint moved through a gait cycle. While the three-dimensional model corroborated predictions of the previously published two-dimensional model that misalignments in the anterior -posterior direction would result in greater relative motion compared to misalignments in the proximal -distal direction, it provided greater insight showing that misalignments have asymmetrical effects. The three-dimensional model has been incorporated into a freely available computer program to assist others in understanding the consequences of joint misalignments. Models and simulations can be used to gain insight into functioning of systems of interest. We have developed a three-dimensional model to assess the effect of ankle joint axis misalignments in ankle-foot orthoses. The model has been incorporated into a freely available computer program to assist understanding of trainees and others interested in orthotics. © The International Society for Prosthetics and Orthotics 2014.

LAGRANGIAN MODELING OF A SUSPENDED-SEDIMENT PULSE.

USGS Publications Warehouse

Schoellhamer, David H.

1987-01-01

The one-dimensional Lagrangian Transport Model (LTM) has been applied in a quasi two-dimensional manner to simulate the transport of a slug injection of microbeads in steady experimental flows. A stationary bed segment was positioned below each parcel location to simulate temporary storage of beads on the bottom of the flume. Only one degree of freedom was available for all three bead simulations. The results show the versatility of the LTM and the ability of the LTM to accurately simulate transport of fine suspended sediment.

A three-dimensional wide-angle BPM for optical waveguide structures.

PubMed

Ma, Changbao; Van Keuren, Edward

2007-01-22

Algorithms for effective modeling of optical propagation in three- dimensional waveguide structures are critical for the design of photonic devices. We present a three-dimensional (3-D) wide-angle beam propagation method (WA-BPM) using Hoekstra's scheme. A sparse matrix algebraic equation is formed and solved using iterative methods. The applicability, accuracy and effectiveness of our method are demonstrated by applying it to simulations of wide-angle beam propagation, along with a technique for shifting the simulation window to reduce the dimension of the numerical equation and a threshold technique to further ensure its convergence. These techniques can ensure the implementation of iterative methods for waveguide structures by relaxing the convergence problem, which will further enable us to develop higher-order 3-D WA-BPMs based on Padé approximant operators.

Three-Dimensional Finite Element Ablative Thermal Response and Thermostructural Design of Thermal Protection Systems

NASA Technical Reports Server (NTRS)

Dec, John A.; Braun, Robert D.

2011-01-01

A finite element ablation and thermal response program is presented for simulation of three-dimensional transient thermostructural analysis. The three-dimensional governing differential equations and finite element formulation are summarized. A novel probabilistic design methodology for thermal protection systems is presented. The design methodology is an eight step process beginning with a parameter sensitivity study and is followed by a deterministic analysis whereby an optimum design can determined. The design process concludes with a Monte Carlo simulation where the probabilities of exceeding design specifications are estimated. The design methodology is demonstrated by applying the methodology to the carbon phenolic compression pads of the Crew Exploration Vehicle. The maximum allowed values of bondline temperature and tensile stress are used as the design specifications in this study.

Recent developments in structural proteomics for protein structure determination.

PubMed

Liu, Hsuan-Liang; Hsu, Jyh-Ping

2005-05-01

The major challenges in structural proteomics include identifying all the proteins on the genome-wide scale, determining their structure-function relationships, and outlining the precise three-dimensional structures of the proteins. Protein structures are typically determined by experimental approaches such as X-ray crystallography or nuclear magnetic resonance (NMR) spectroscopy. However, the knowledge of three-dimensional space by these techniques is still limited. Thus, computational methods such as comparative and de novo approaches and molecular dynamic simulations are intensively used as alternative tools to predict the three-dimensional structures and dynamic behavior of proteins. This review summarizes recent developments in structural proteomics for protein structure determination; including instrumental methods such as X-ray crystallography and NMR spectroscopy, and computational methods such as comparative and de novo structure prediction and molecular dynamics simulations.

A three-dimensional wide-angle BPM for optical waveguide structures

NASA Astrophysics Data System (ADS)

Ma, Changbao; van Keuren, Edward

2007-01-01

Algorithms for effective modeling of optical propagation in three- dimensional waveguide structures are critical for the design of photonic devices. We present a three-dimensional (3-D) wide-angle beam propagation method (WA-BPM) using Hoekstra’s scheme. A sparse matrix algebraic equation is formed and solved using iterative methods. The applicability, accuracy and effectiveness of our method are demonstrated by applying it to simulations of wide-angle beam propagation, along with a technique for shifting the simulation window to reduce the dimension of the numerical equation and a threshold technique to further ensure its convergence. These techniques can ensure the implementation of iterative methods for waveguide structures by relaxing the convergence problem, which will further enable us to develop higher-order 3-D WA-BPMs based on Padé approximant operators.

Simulation of freshwater-saltwater interfaces in the Brooklyn-Queens aquifer system, Long Island, New York

USGS Publications Warehouse

Kontis, Angelo L.

1999-01-01

The seaward limit of the fresh ground-water system underlying Kings and Queens Counties on Long Island, N.Y., is at the freshwater-saltwater transition zone. This zone has been conceptualized in transient-state, three-dimensional models of the aquifer system as a sharp interface between freshwater and saltwater, and represented as a stationary, zero lateral-flow boundary. In this study, a pair of two-dimensional, four-layer ground-water flow models representing a generalized vertical section in Kings County and one in adjacent Queens County were developed to evaluate the validity of the boundary condition used in three-dimensional models of the aquifer system. The two-dimensional simulations used a model code that can simulate the movement of a sharp interface in response to transient stress. Sensitivity of interface movement to four factors was analyzed; these were (1) the method of simulating vertical leakage between freshwater and saltwater; (2) recharge at the normal rate, at 50-percent of the normal rate, and at zero for a prolonged (3-year) period; (3) high, medium, and low pumping rates; and (4) pumping from a hypothetical cluster of wells at two locations. Results indicate that the response of the interfaces to the magnitude and duration of pumping and the location of the hypothetical wells is probably sufficiently slow that the interfaces in three-dimensional models can reasonably be approximated as stationary, zero-lateral- flow boundaries.

Speckle contrast optical tomography: A new method for deep tissue three-dimensional tomography of blood flow

PubMed Central

Varma, Hari M.; Valdes, Claudia P.; Kristoffersen, Anna K.; Culver, Joseph P.; Durduran, Turgut

2014-01-01

A novel tomographic method based on the laser speckle contrast, speckle contrast optical tomography (SCOT) is introduced that allows us to reconstruct three dimensional distribution of blood flow in deep tissues. This method is analogous to the diffuse optical tomography (DOT) but for deep tissue blood flow. We develop a reconstruction algorithm based on first Born approximation to generate three dimensional distribution of flow using the experimental data obtained from tissue simulating phantoms. PMID:24761306

Alphatome--Enhancing Spatial Reasoning: A Simulation in Two and Three Dimensions

ERIC Educational Resources Information Center

LeClair, Elizabeth E.

2003-01-01

Using refrigerator magnets, foam blocks, ink pads, and modeling clay, students manipulate the letters of the alphabet at multiple angles, reconstructing three-dimensional forms from two-dimensional data. This exercise increases students' spatial reasoning ability, an important component in many scientific disciplines. (Contains 5 figures.)

Real-time application of advanced three-dimensional graphic techniques for research aircraft simulation

NASA Technical Reports Server (NTRS)

Davis, Steven B.

1990-01-01

Visual aids are valuable assets to engineers for design, demonstration, and evaluation. Discussed here are a variety of advanced three-dimensional graphic techniques used to enhance the displays of test aircraft dynamics. The new software's capabilities are examined and possible future uses are considered.

Simulating Geriatric Home Safety Assessments in a Three-Dimensional Virtual World

ERIC Educational Resources Information Center

Andrade, Allen D.; Cifuentes, Pedro; Mintzer, Michael J.; Roos, Bernard A.; Anam, Ramanakumar; Ruiz, Jorge G.

2012-01-01

Virtual worlds could offer inexpensive and safe three-dimensional environments in which medical trainees can learn to identify home safety hazards. Our aim was to evaluate the feasibility, usability, and acceptability of virtual worlds for geriatric home safety assessments and to correlate performance efficiency in hazard identification with…

Modeling Cometary Coma with a Three Dimensional, Anisotropic Multiple Scattering Distributed Processing Code

NASA Technical Reports Server (NTRS)

Luchini, Chris B.

1997-01-01

Development of camera and instrument simulations for space exploration requires the development of scientifically accurate models of the objects to be studied. Several planned cometary missions have prompted the development of a three dimensional, multi-spectral, anisotropic multiple scattering model of cometary coma.

Analysis Of FEL Optical Systems With Grazing Incidence Mirrors

NASA Astrophysics Data System (ADS)

Knapp, C. E.; Viswanathan, V. K.; Bender, S. C.; Appert, Q. D.; Lawrence, G.; Barnard, C.

1986-11-01

The use of grazing incidence optics in resonators alleviates the problem of damage to the optical elements and permits higher powers in cavities of reasonable dimensions for a free electron laser (FEL). The design and manufacture of a grazing incidence beam expander for the Los Alamos FEL mock up has been completed. In this paper, we describe the analysis of a bare cavity, grazing incidence optical beam expander for an FEL system. Since the existing geometrical and physical optics codes were inadequate for such an analysis, the GLAD code was modified to include global coordinates, exact conic representation, raytracing, and exact aberration features to determine the alignment sensitivities of laser resonators. A resonator cavity has been manufactured and experimentally setup in the Optical Evaluation Laboratory at Los Alamos. Calculated performance is compared with the laboratory measurements obtained so far.

DC High Voltage Conditioning of Photoemission Guns at Jefferson Lab FEL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hernandez-Garcia, C.; Benson, S. V.; Biallas, G.

2009-08-04

DC high voltage photoemission electron guns with GaAs photocathodes have been used to produce polarized electron beams for nuclear physics experiments for about 3 decades with great success. In the late 1990s, Jefferson Lab adopted this gun technology for a free electron laser (FEL), but to assist with high bunch charge operation, considerably higher bias voltage is required compared to the photoguns used at the Jefferson Lab Continuous Electron Beam Accelerator Facility. The FEL gun has been conditioned above 400 kV several times, albeit encountering non-trivial challenges with ceramic insulators and field emission from electrodes. Recently, high voltage processing withmore » krypton gas was employed to process very stubborn field emitters. This work presents a summary of the high voltage techniques used to high voltage condition the Jefferson Lab FEL photoemission gun.« less

Basic design considerations for free-electron lasers driven by electron beams from RF accelerators

NASA Astrophysics Data System (ADS)

Gover, A.; Freund, H.; Granatstein, V. L.; McAdoo, J. H.; Tang, C.-M.

A design procedure and design criteria are derived for free-electron lasers driven by electron beams from RF accelerators. The procedure and criteria permit an estimate of the oscillation-buildup time and the laser output power of various FEL schemes: with waveguide resonator or open resonator, with initial seed-radiation injection or with spontaneous-emission radiation source, with a linear wiggler or with a helical wiggler. Expressions are derived for computing the various FEL parameters, allowing for the design and optimization of the FEL operational characteristics under ideal conditions or with nonideal design parameters that may be limited by technological or practical constraints. The design procedure enables one to derive engineering curves and scaling laws for the FEL operating parameters. This can be done most conveniently with a computer program based on flowcharts given in the appendices.

Electron and ion heating by whistler turbulence: Three-dimensional particle-in-cell simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hughes, R. Scott; Gary, S. Peter; Wang, Joseph

2014-12-17

Three-dimensional particle-in-cell simulations of decaying whistler turbulence are carried out on a collisionless, homogeneous, magnetized, electron-ion plasma model. In addition, the simulations use an initial ensemble of relatively long wavelength whistler modes with a broad range of initial propagation directions with an initial electron beta β e = 0.05. The computations follow the temporal evolution of the fluctuations as they cascade into broadband turbulent spectra at shorter wavelengths. Three simulations correspond to successively larger simulation boxes and successively longer wavelengths of the initial fluctuations. The computations confirm previous results showing electron heating is preferentially parallel to the background magnetic fieldmore » B o, and ion heating is preferentially perpendicular to B o. The new results here are that larger simulation boxes and longer initial whistler wavelengths yield weaker overall dissipation, consistent with linear dispersion theory predictions of decreased damping, stronger ion heating, consistent with a stronger ion Landau resonance, and weaker electron heating.« less

Vulnerability of Population and Transportation Infrastructure at the East Bank of Delaware Bay Due to Coastal Flooding in Sea-Level Rise Conditions

DTIC Science & Technology

2013-04-30

resulting impact on residents and transportation infrastructure. The three-dimensional coastal ocean model FVCOM coupled with a two-dimensional...shallow water model is used to simulate hydrodynamic flooding from coastal ocean water with fine-resolution meshes, and a topography-based hydrologic... ocean model FVCOM coupled with a two-dimensional shallow water model is used to simulate hydrodynamic flooding from coastal ocean water with fine

Morphological Differentiation of Colon Carcinoma Cell Lines in Rotating Wall Vessels

NASA Technical Reports Server (NTRS)

Jessup, J. M.

1994-01-01

The objectives of this project were to determine whether (1) microgravity permits unique, three-dimensional cultures of neoplastic human colon tissues and (2) this culture interaction produces novel intestinal growth and differentiation factors. The initial phase of this project tested the efficacy of simulated microgravity for the cultivation and differentiation of human colon carcinoma in rotating wall vessels (RWV's) on microcarrier beads. The RWV's simulate microgravity by randomizing the gravity vector in an aqueous medium under a low shear stress environment in unit gravity. This simulation achieves approximately a one-fifth g environment that allows cells to 'float' and form three-dimensional relationships with less shear stress than in other stirred aqueous medium bioreactors. In the second phase of this project we assessed the ability of human colon carcinoma lines to adhere to various substrates because adhesion is the first event that must occur to create three-dimensional masses. Finally, we tested growth factor production in the last phase of this project.

High-Fidelity Three-Dimensional Simulation of the GE90

NASA Technical Reports Server (NTRS)

Turner, Mark G.; Norris, Andrew; Veres, Josphe P.

2004-01-01

A full-engine simulation of the three-dimensional flow in the GE90 94B high-bypass ratio turbofan engine has been achieved. It would take less than 11 hr of wall clock time if starting from scratch through the exploitation of parallel processing. The simulation of the compressor components, the cooled high-pressure turbine, and the low-pressure turbine was performed using the APNASA turbomachinery flow code. The combustor flow and chemistry were simulated using the National Combustor Code (NCC). The engine simulation matches the engine thermodynamic cycle for a sea-level takeoff condition. The simulation is started at the inlet of the fan and progresses downstream. Comparisons with the cycle point are presented. A detailed look at the blockage in the turbomachinery is presented as one measure to assess and view the solution and the multistage interaction effects.

Three-dimensional magnetohydrodynamical simulation of expanding magnetic flux ropes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arnold, L.; Dreher, J.; Grauer, R.

Three-dimensional, time-dependent numerical simulations of the dynamics of magnetic flux ropes are presented. The simulations are targeted towards an experiment previously conducted at California Institute of Technology [P. M. Bellan and J. F. Hansen, Phys. Plasmas 5, 1991 (1998)] which aimed at simulating solar prominence eruptions in the laboratory. The plasma dynamics is described by ideal magnetohydrodynamics using different models for the evolution of the mass density. The initial current distribution represents the situation at the plasma creation phase, while it is not increased during the simulation. Key features of the reported experimental observations like pinching of the current loop,more » its expansion and distortion into helical shape are reproduced in the numerical simulations. Details of the final structure depend on the choice of a specific model for the mass density.« less

Fiber Composite Sandwich Thermostructural Behavior: Computational Simulation

NASA Technical Reports Server (NTRS)

Chamis, C. C.; Aiello, R. A.; Murthy, P. L. N.

1986-01-01

Several computational levels of progressive sophistication/simplification are described to computationally simulate composite sandwich hygral, thermal, and structural behavior. The computational levels of sophistication include: (1) three-dimensional detailed finite element modeling of the honeycomb, the adhesive and the composite faces; (2) three-dimensional finite element modeling of the honeycomb assumed to be an equivalent continuous, homogeneous medium, the adhesive and the composite faces; (3) laminate theory simulation where the honeycomb (metal or composite) is assumed to consist of plies with equivalent properties; and (4) derivations of approximate, simplified equations for thermal and mechanical properties by simulating the honeycomb as an equivalent homogeneous medium. The approximate equations are combined with composite hygrothermomechanical and laminate theories to provide a simple and effective computational procedure for simulating the thermomechanical/thermostructural behavior of fiber composite sandwich structures.

The Physics and Applications of High Brightness Beams: Working Group C Summary on Applications to FELS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nuhn, Heinz-Dieter

2003-03-19

This is the summary of the activities in working group C, ''Application to FELs,'' which was based in the Bithia room at the Joint ICFA Advanced Accelerator and Beam Dynamics Workshop on July 1-6, 2002 in Chia Laguna, Sardinia, Italy. Working group C was small in relation to the other working groups at that workshop. Attendees include Enrica Chiadroni, University of Rome ape with an identical pulse length. ''La Sapienza'', Luca Giannessi, ENEA, Steve Lidia, LBNL, Vladimir Litvinenko, Duke University, Patrick Muggli, UCLA, Alex Murokh, UCLA, Heinz-Dieter Nuhn, SLAC, Sven Reiche, UCLA, Jamie Rosenzweig, UCLA, Claudio Pellegrini, UCLA, Susan Smith,more » Daresbury Laboratory, Matthew Thompson, UCLA, Alexander Varfolomeev, Russian Research Center, plus a small number of occasional visitors. The working group addressed a total of nine topics. Each topic was introduced by a presentation, which initiated a discussion of the topic during and after the presentation. The speaker of the introductory presentation facilitated the discussion. There were six topics that were treated in stand-alone sessions of working group C. In addition, there were two joint sessions, one with working group B, which included one topic, and one with working group C, which included two topics. The presentations that were given in the joint sessions are summarized in the working group summary reports for groups B and D, respectively. This summary will only discuss the topics that were addressed in the stand-alone sessions, including Start-To-End Simulations, SASE Experiment, PERSEO, ''Optics Free'' FEL Oscillators, and VISA II.« less

[Three-dimensional display simulation of lung surgery using "active shutter glasses"].

PubMed

Onuki, Takamasa; Kanzaki, Masato; Sakamoto, Kei; Kikkawa, Takuma; Isaka, Tamami; Shimizu, Toshihide; Oyama, Kunihiro; Murasugi, Masahide

2011-08-01

We have reported preoperative 3-dimensional (3D) simulation of thoracoscopic lung surgery using self-made software and internet shareware of 3D-modeler. Using "active shutter glasses", we have tried the "3D display simulation" of lung surgery. 3D display was more effective to grasp clear 3D interrelation between the bronchii and pulmonary vascular system than those in images of currently in use with the same information volume.

Direct experimental observation of the gas density depression effect using a two-bunch X-ray FEL beam.

PubMed

Feng, Y; Schafer, D W; Song, S; Sun, Y; Zhu, D; Krzywinski, J; Robert, A; Wu, J; Decker, F J

2018-01-01

The experimental observation of the depression effect in gas devices designed for X-ray free-electron lasers (FELs) is reported. The measurements were carried out at the Linac Coherent Light Source using a two-bunch FEL beam at 6.5 keV with 122.5 ns separation passing through an argon gas cell. The relative intensities of the two pulses of the two-bunch beam were measured, after and before the gas cell, from X-ray scattering off thin targets by using fast diodes with sufficient temporal resolution. At a cell pressure of 140 hPa, it was found that the after-to-before ratio of the intensities of the second pulse was about 17% ± 6% higher than that of the first pulse, revealing lower effective attenuation of the gas cell due to heating by the first pulse and subsequent gas density reduction in the beam path. This measurement is important in guiding the design and/or mitigating the adverse effects in gas devices for high-repetition-rate FELs such as the LCLS-II and the European XFEL or other future high-repetition-rate upgrades to existing FEL facilities.

Direct experimental observation of the gas density depression effect using a two-bunch X-ray FEL beam

DOE PAGES

Feng, Y.; Schafer, D. W.; Song, S.; ...

2018-01-01

The experimental observation of the depression effect in gas devices designed for X-ray free-electron lasers (FELs) is reported. The measurements were carried out at the Linac Coherent Light Source using a two-bunch FEL beam at 6.5 keV with 122.5 ns separation passing through an argon gas cell. The relative intensities of the two pulses of the two-bunch beam were measured, after and before the gas cell, from X-ray scattering off thin targets by using fast diodes with sufficient temporal resolution. At a cell pressure of 140 hPa, it was found that the after-to-before ratio of the intensities of the secondmore » pulse was about 17% ± 6% higher than that of the first pulse, revealing lower effective attenuation of the gas cell due to heating by the first pulse and subsequent gas density reduction in the beam path. Furthermore, this measurement is important in guiding the design and/or mitigating the adverse effects in gas devices for high-repetition-rate FELs such as the LCLS-II and the European XFEL or other future high-repetition-rate upgrades to existing FEL facilities.« less

Direct experimental observation of the gas density depression effect using a two-bunch X-ray FEL beam

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feng, Y.; Schafer, D. W.; Song, S.

The experimental observation of the depression effect in gas devices designed for X-ray free-electron lasers (FELs) is reported. The measurements were carried out at the Linac Coherent Light Source using a two-bunch FEL beam at 6.5 keV with 122.5 ns separation passing through an argon gas cell. The relative intensities of the two pulses of the two-bunch beam were measured, after and before the gas cell, from X-ray scattering off thin targets by using fast diodes with sufficient temporal resolution. At a cell pressure of 140 hPa, it was found that the after-to-before ratio of the intensities of the secondmore » pulse was about 17% ± 6% higher than that of the first pulse, revealing lower effective attenuation of the gas cell due to heating by the first pulse and subsequent gas density reduction in the beam path. Furthermore, this measurement is important in guiding the design and/or mitigating the adverse effects in gas devices for high-repetition-rate FELs such as the LCLS-II and the European XFEL or other future high-repetition-rate upgrades to existing FEL facilities.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Litvinenko,V.; Yakimenko, V.

We propose undertaking a demonstration experiment on suppressing spontaneous undulator radiation from an electron beam at BNL's Accelerator Test Facility (ATF). We describe the method, the proposed layout, and a possible schedule. There are several advantages in strongly suppressing shot noise in the electron beam, and the corresponding spontaneous radiation. The self-amplified spontaneous (SASE) emission originating from shot noise in the electron beam is the main source of noise in high-gain FEL amplifiers. It may negatively affect several HG FEL applications ranging from single- to multi-stage HGHG FELs. SASE saturation also imposes a fundamental hard limit on the gain ofmore » an FEL amplifier in a coherent electron-cooling scheme. A novel active method for suppressing shot noise in relativistic electron beams by many orders-of-magnitude was recently proposed. While theoretically such strong suppression appears feasible, the performance and applicability of this novel method must be evaluated experimentally. Several practical questions about the proposed noise suppressor, such as 3D effects and/or sensitivity to the e-beam parameters also require experimental clarification. To do this, we propose here a proof-of-principle experiment using elements of the VISA FEL at BNL's Accelerator Test Facility.« less

Bunch Length Measurements at JLab FEL

DOE Office of Scientific and Technical Information (OSTI.GOV)

P. Evtushenko; J. L. Coleman; K. Jordan

2006-09-01

The JLab FEL is routinely operated with sub-picosecond bunches. The short bunch length is important for high gain of the FEL. Coherent transition radiation has been used for the bunch length measurements for many years. This diagnostic can be used only in the pulsed beam mode. It is our goal to run FEL with CW beam and 74.85 MHz micropulse repetition rate. Hence it is very desirable to have the possibility of doing the bunch length measurements when running CW beam with any micropulse frequency. We use a Fourier transform infrared interferometer, which is essentially a Michelson interferometer, to measuremore » the spectrum of the coherent synchrotron radiation generated in the last dipole of the magnetic bunch compressor upstream of the FEL wiggler. This noninvasive diagnostic provides the bunch length measurements for CW beam operation at any micropulse frequency. We also compare the measurements made with the help of the FTIR interferometer with the data obtained by the Martin-Puplett interferometer. Results of the two diagnostics are usually agree within 15%. Here we present a description of the experimental setup, data evaluation procedure and results of the beam measurements.« less

UCSB FEL user-mode adaption project. Final report, 1 Jan 86-31 Dec 90

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jaccarino, V.

1992-04-14

This research sponsored by the SDIO Biomedical and Materials Sciences FEL Program held the following objectives. Provide a facility in which in-house and outside user research in the materials and biological sciences can be carried out in the Far Infrared using-the unique properties of the UCSB electrostatic accelerator-driven FEL. Develop and implement new FEL concepts and FIR technology and encourage the transfer and application of this research. Train graduate students, post doctoral researchers and technical personnel in varied aspects of scientific user disciplines, FEL science and FIR technology in a cooperative, interdisciplinary environment. In summary, a free electron laser facilitymore » has been developed which is operational from 200 GH z, (6.6 cm -1), to 4.8 THz, (160 cm-1) tunable under computer control and able to deliver kilowatts of millimeter wave and far-infrared power. This facility has a well equipped user lab that has been used to perform ground breaking experiments in scientific areas as diverse as bio-physics. Nine graduate students and post doctoral researchers have been trained in the operation, use and application of these free-electron lasers.« less

Media Compositions for Three Dimensional Mammalian Tissue Growth Under Microgravity Culture Conditions

NASA Technical Reports Server (NTRS)

Goodwin, Thomas J. (Inventor)

1998-01-01

Normal mammalian tissue and the culturing process has been developed for the three groups of organ, structural and blood tissue. The cells are grown in vitro under microgravity culture conditions and form three dimensional cells aggregates with normal cell function. The microgravity culture conditions may be microgravity or simulated microgravity created in a horizontal rotating wall culture vessel.

Media Compositions for Three-Dimensional Mammalian Tissue Growth under Microgravity Culture Conditions

NASA Technical Reports Server (NTRS)

Goodwin, Thomas J. (Inventor)

1998-01-01

Normal mammalian tissue and the culturing process has been developed for the three groups of organ, structural and blood tissue.The cells are grown in vitro under microgravity culture conditions and form three dimensional cells aggregates with normal cell function. The microgravity culture conditions may be microgravity or simulated microgravity created in a horizontal rotating wall culture vessel.

Electron Source based on Superconducting RF

NASA Astrophysics Data System (ADS)

Xin, Tianmu

High-bunch-charge photoemission electron-sources operating in a Continuous Wave (CW) mode can provide high peak current as well as the high average current which are required for many advanced applications of accelerators facilities, for example, electron coolers for hadron beams, electron-ion colliders, and Free-Electron Lasers (FELs). Superconducting Radio Frequency (SRF) has many advantages over other electron-injector technologies, especially when it is working in CW mode as it offers higher repetition rate. An 112 MHz SRF electron photo-injector (gun) was developed at Brookhaven National Laboratory (BNL) to produce high-brightness and high-bunch-charge bunches for electron cooling experiments. The gun utilizes a Quarter-Wave Resonator (QWR) geometry for a compact structure and improved electron beam dynamics. The detailed RF design of the cavity, fundamental coupler and cathode stalk are presented in this work. A GPU accelerated code was written to improve the speed of simulation of multipacting, an important hurdle the SRF structure has to overcome in various locations. The injector utilizes high Quantum Efficiency (QE) multi-alkali photocathodes (K2CsSb) for generating electrons. The cathode fabrication system and procedure are also included in the thesis. Beam dynamic simulation of the injector was done with the code ASTRA. To find the optimized parameters of the cavities and beam optics, the author wrote a genetic algorithm Python script to search for the best solution in this high-dimensional parameter space. The gun was successfully commissioned and produced world record bunch charge and average current in an SRF photo-injector.

X-ray system simulation software tools for radiology and radiography education.

PubMed

Kengyelics, Stephen M; Treadgold, Laura A; Davies, Andrew G

2018-02-01

To develop x-ray simulation software tools to support delivery of radiological science education for a range of learning environments and audiences including individual study, lectures, and tutorials. Two software tools were developed; one simulated x-ray production for a simple two dimensional radiographic system geometry comprising an x-ray source, beam filter, test object and detector. The other simulated the acquisition and display of two dimensional radiographic images of complex three dimensional objects using a ray casting algorithm through three dimensional mesh objects. Both tools were intended to be simple to use, produce results accurate enough to be useful for educational purposes, and have an acceptable simulation time on modest computer hardware. The radiographic factors and acquisition geometry could be altered in both tools via their graphical user interfaces. A comparison of radiographic contrast measurements of the simulators to a real system was performed. The contrast output of the simulators had excellent agreement with measured results. The software simulators were deployed to 120 computers on campus. The software tools developed are easy-to-use, clearly demonstrate important x-ray physics and imaging principles, are accessible within a standard University setting and could be used to enhance the teaching of x-ray physics to undergraduate students. Current approaches to teaching x-ray physics in radiological science lack immediacy when linking theory with practice. This method of delivery allows students to engage with the subject in an experiential learning environment. Copyright © 2017. Published by Elsevier Ltd.

Incorporation of a PbSe Array Based Spectrograph into EPICS using LabView at the JLab FEL Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

D. Hardy; S.V. Benson; Michelle D. Shinn

2005-08-21

A real-time spectrograph with a 1Hz update rate was designed and installed at the JLab FEL facility using a Cal Sensors PbSe array and a Roper Scientific SpectraPro 300 monochrometer. This paper describes the implementation of EPICS channel access on a remote PC running LabView with modification of vendor supplied LabView VI's to allow display of FEL light spectra in real-time on a remote workstation. This allows PC based diagnostics to be used in EPICS.

Flavonoids as potent allosteric inhibitors of protein tyrosine phosphatase 1B: molecular dynamics simulation and free energy calculation.

PubMed

Zargari, Farshid; Lotfi, Maryam; Shahraki, Omolbanin; Nikfarjam, Zahra; Shahraki, Jafar

2017-12-11

Protein tyrosine phosphatase 1B (PTP1B) is a member of the PTP superfamily which is considered to be a negative regulator of insulin receptor (IR) signaling pathway. PTP1B is a promising drug target for the treatment of type 2 diabetes, obesity, and cancer. The existence of allosteric site in PTP1B has turned the researcher's attention to an alternate strategy for inhibition of this enzyme. Herein, the molecular interactions between the allosteric site of PTP1B with three non-competitive flavonoids, (MOR), (MOK), and (DPO) have been investigated. Three ligands were docked into allosteric site of the enzyme. The resulting protein-ligand complexes were used for molecular dynamics studies. Principal component and free-energy landscape (FEL) as well as cluster analyses were used to investigate the conformational and dynamical properties of the protein and identify representative enzyme substrates bounded to the inhibitors. Per residue energy decomposition analysis attributed dissimilar affinities of three inhibitors to the several hydrogen bonds and non-bonded interactions. In conclusion, our results exhibited an inhibitory pattern of the ligands against PTP1B.

The Helioseismic and Magnetic Imager (HMI) Vector Magnetic Field Pipeline: Magnetohydrodynamics Simulation Module for the Global Solar Corona.

PubMed

Hayashi, K; Hoeksema, J T; Liu, Y; Bobra, M G; Sun, X D; Norton, A A

Time-dependent three-dimensional magnetohydrodynamics (MHD) simulation modules are implemented at the Joint Science Operation Center (JSOC) of the Solar Dynamics Observatory (SDO). The modules regularly produce three-dimensional data of the time-relaxed minimum-energy state of the solar corona using global solar-surface magnetic-field maps created from Helioseismic and Magnetic Imager (HMI) full-disk magnetogram data. With the assumption of a polytropic gas with specific-heat ratio of 1.05, three types of simulation products are currently generated: i) simulation data with medium spatial resolution using the definitive calibrated synoptic map of the magnetic field with a cadence of one Carrington rotation, ii) data with low spatial resolution using the definitive version of the synchronic frame format of the magnetic field, with a cadence of one day, and iii) low-resolution data using near-real-time (NRT) synchronic format of the magnetic field on a daily basis. The MHD data available in the JSOC database are three-dimensional, covering heliocentric distances from 1.025 to 4.975 solar radii, and contain all eight MHD variables: the plasma density, temperature, and three components of motion velocity, and three components of the magnetic field. This article describes details of the MHD simulations as well as the production of the input magnetic-field maps, and details of the products available at the JSOC database interface. To assess the merits and limits of the model, we show the simulated data in early 2011 and compare with the actual coronal features observed by the Atmospheric Imaging Assembly (AIA) and the near-Earth in-situ data.

Dog allergen (Can f 1) and cat allergen (Fel d 1) in US homes: Results from the National Survey of Lead and Allergens in Housing

PubMed Central

Arbes, Samuel J.; Cohn, Richard D.; Yin, Ming; Muilenberg, Michael L.; Friedman, Warren; Zeldin, Darryl C.

2017-01-01

Background Exposures to dog and cat allergens are believed to play important roles in the etiology of asthma; however, the levels of these allergens have never been assessed in a representative sample of US homes. Objective The objective of this study was to estimate and characterize exposures to Can f 1 (dog allergen) and Fel d 1 (cat allergen) in US homes. Methods Data were obtained from the National Survey of Lead and Allergens in Housing, a nationally representative survey of 831 US homes. Vacuumed-collected dust samples from the bed, bedroom floor, living room floor, and living room sofa were analyzed for concentrations of Can f 1 and Fel d 1 (micrograms of allergen per gram of dust). Results Although a dog or cat had lived in only 49.1% of homes in the previous 6 months, Can f 1 and Fel d 1 were detected in 100% and 99.9% of homes, respectively. Averaged over the sampled sites, geometric mean concentrations (µg/g) were 4.69 for Can f 1 and 4.73 for Fel d 1. Among homes with an indoor dog and cat, respectively, geometric mean concentrations were 69 for Can f 1 and 200 for Fel d 1. Among homes without the indoor pet, geometric mean concentrations were above 1.0. The independent predictors of elevated concentrations in homes without pets were all demographic variables that were also linked to a higher prevalence of pet ownership. Conclusions Can f 1 and Fel d 1 are universally present in US homes. Levels that have been associated with an increased risk of allergic sensitization were found even in homes without pets. Because of the transportability of these allergens on clothing, elevated levels in homes without pets, particularly among demographic groups in which pet ownership is more prevalent, implicate the community as an important source of these pet allergens. PMID:19055206

Interobserver variation in the diagnosis of fibroepithelial lesions of the breast: a multicentre audit by digital pathology.

PubMed

Dessauvagie, Benjamin F; Lee, Andrew H S; Meehan, Katie; Nijhawan, Anju; Tan, Puay Hoon; Thomas, Jeremy; Tie, Bibiana; Treanor, Darren; Umar, Seemeen; Hanby, Andrew M; Millican-Slater, Rebecca

2018-02-13

Fibroepithelial lesions (FELs) of the breast span a morphological continuum including lesions where distinction between cellular fibroadenoma (FA) and benign phyllodes tumour (PT) is difficult. The distinction is clinically important with FAs managed conservatively while equivocal lesions and PTs are managed with surgery. We sought to audit core biopsy diagnoses of equivocal FELs by digital pathology and to investigate whether digital point counting is useful in clarifying FEL diagnoses. Scanned slide images from cores and subsequent excisions of 69 equivocal FELs were examined in a multicentre audit by eight pathologists to determine the agreement and accuracy of core needle biopsy (CNB) diagnoses and by digital point counting of stromal cellularity and expansion to determine if classification could be improved. Interobserver variation was high on CNB with a unanimous diagnosis from all pathologists in only eight cases of FA, diagnoses of both FA and PT on the same CNB in 15 and a 'weak' mean kappa agreement between pathologists (k=0.36). 'Moderate' agreement was observed on CNBs among breast specialists (k=0.44) and on excision samples (k=0.49). Up to 23% of lesions confidently diagnosed as FA on CNB were PT on excision and up to 30% of lesions confidently diagnosed as PT on CNB were FA on excision. Digital point counting did not aid in the classification of FELs. Accurate and reproducible diagnosis of equivocal FELs is difficult, particularly on CNB, resulting in poor interobserver agreement and suboptimal accuracy. Given the diagnostic difficulty, and surgical implications, equivocal FELs should be reported in consultation with experienced breast pathologists as a small number of benign FAs can be selected out from equivocal lesions. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Targeting allergen to FcgammaRI reveals a novel T(H)2 regulatory pathway linked to thymic stromal lymphopoietin receptor.

PubMed

Hulse, Kathryn E; Reefer, Amanda J; Engelhard, Victor H; Patrie, James T; Ziegler, Steven F; Chapman, Martin D; Woodfolk, Judith A

2010-01-01

The molecule H22-Fel d 1, which targets cat allergen to FcgammaRI on dendritic cells (DCs), has the potential to treat cat allergy because of its T-cell modulatory properties. We sought to investigate whether the T-cell response induced by H22-Fel d 1 is altered in the presence of the T(H)2-promoting cytokine thymic stromal lymphopoietin (TSLP). Studies were performed in subjects with cat allergy with and without atopic dermatitis. Monocyte-derived DCs were primed with H22-Fel d 1 in the presence or absence of TSLP, and the resulting T-cell cytokine repertoire was analyzed by flow cytometry. The capacity for H22-Fel d 1 to modulate TSLP receptor expression on DCs was examined by flow cytometry in the presence or absence of inhibitors of Fc receptor signaling molecules. Surprisingly, TSLP alone was a weak inducer of T(H)2 responses irrespective of atopic status; however, DCs coprimed with TSLP and H22-Fel d 1 selectively and synergistically amplified T(H)2 responses in highly atopic subjects. This effect was OX40 ligand independent, pointing to an unconventional TSLP-mediated pathway. Expression of TSLP receptor was upregulated on atopic DCs primed with H22-Fel d 1 through a pathway regulated by FcgammaRI-associated signaling components, including src-related tyrosine kinases and Syk, as well as the downstream molecule phosphoinositide 3-kinase. Inhibition of TSLP receptor upregulation triggered by H22-Fel d 1 blocked TSLP-mediated T(H)2 responses. Discovery of a novel T(H)2 regulatory pathway linking FcgammaRI signaling to TSLP receptor upregulation and consequent TSLP-mediated effects questions the validity of receptor-targeted allergen vaccines. Copyright 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.