24 CFR 3280.610 - Drainage systems.

Code of Federal Regulations, 2012 CFR

2012-04-01

... individually vented. (iii) A 3-inch minimum diameter piping shall be required for water closets. (f) Wet-vented... water seal trap (§ 3280.606(a)). (2) The drainage system shall be designed to provide an adequate... equipped with a water-tight cap or plug matching the drain outlet. The cap or plug shall be permanently...

24 CFR 3280.610 - Drainage systems.

Code of Federal Regulations, 2013 CFR

2013-04-01

... individually vented. (iii) A 3-inch minimum diameter piping shall be required for water closets. (f) Wet-vented... water seal trap (§ 3280.606(a)). (2) The drainage system shall be designed to provide an adequate... equipped with a water-tight cap or plug matching the drain outlet. The cap or plug shall be permanently...

Evaluation production index of test well about tight gas reservoir

NASA Astrophysics Data System (ADS)

Huang, Xiaoliang; Yan, Wende; Yuan, Yingzhong; Li, Jiqiang; Li, Xiaoxue

2018-03-01

It is important that the tight gas reservoir is developed with test wells in the first place for the reasonable development, and it is necessary evaluation production index of test well. So, the paper will evaluate gas wells capacity, reasonable production, production decline law and producing reserves. Combining with calculation theory, comparison of adjacent wells and field practice, obtained reasonable production, production decline law and production reserves about test well, and through analysis the adjacent well obtained development experience and lessons about tight gas reservoir. The results show that the gas well development should pay attention to reasonable production and prevent energy falling too fast in tight gas reservoirs, The decline rule of wells with long production time should be analyzed by two stages. Through study, it will provide some reference and guidance for the development of gas wells in tight gas reservoirs.

40 CFR 721.10057 - Dodecanedioic acid, 1, 12-dihydrazide.

Code of Federal Regulations, 2010 CFR

2010-07-01

... significant new uses subject to reporting. (1) The chemical substance identified as dodecanedioic acid, 1, 12-dihydrazide (PMNs P-01-759 and P-05-555; CAS No. 4080-98-2) is subject to reporting under this section for the... respirators meet the minimum requirement for § 721.63(a)(4): Air-purifying, tight-fitting full-face respirator...

Equilibrium structure and atomic vibrations of Nin clusters

NASA Astrophysics Data System (ADS)

Borisova, Svetlana D.; Rusina, Galina G.

2017-12-01

The equilibrium bond lengths and binding energy, second differences in energy and vibrational frequencies of free clusters Nin (2 ≤ n ≤ 20) were calculated with the use of the interaction potential obtained in the tight-binding approximation (TBA). The results show that the minimum vibration frequency plays a significant role in the evaluation of the dynamic stability of the clusters. A nonmonotonic dependence of the minimum vibration frequency of clusters on their size and the extreme values for the number of atoms in a cluster n = 4, 6, 13, and 19 are demonstrated. This result agrees with the theoretical and experimental data on stable structures of small metallic clusters.

Tight bounds for the Pearle-Braunstein-Caves chained inequality without the fair-coincidence assumption

NASA Astrophysics Data System (ADS)

Jogenfors, Jonathan; Larsson, Jan-Åke

2017-08-01

In any Bell test, loopholes can cause issues in the interpretation of the results, since an apparent violation of the inequality may not correspond to a violation of local realism. An important example is the coincidence-time loophole that arises when detector settings might influence the time when detection will occur. This effect can be observed in many experiments where measurement outcomes are to be compared between remote stations because the interpretation of an ostensible Bell violation strongly depends on the method used to decide coincidence. The coincidence-time loophole has previously been studied for the Clauser-Horne-Shimony-Holt and Clauser-Horne inequalities, but recent experiments have shown the need for a generalization. Here, we study the generalized "chained" inequality by Pearle, Braunstein, and Caves (PBC) with N ≥2 settings per observer. This inequality has applications in, for instance, quantum key distribution where it has been used to reestablish security. In this paper we give the minimum coincidence probability for the PBC inequality for all N ≥2 and show that this bound is tight for a violation free of the fair-coincidence assumption. Thus, if an experiment has a coincidence probability exceeding the critical value derived here, the coincidence-time loophole is eliminated.

Thermoelectric module

DOEpatents

Kortier, William E.; Mueller, John J.; Eggers, Philip E.

1980-07-08

A thermoelectric module containing lead telluride as the thermoelectric mrial is encapsulated as tightly as possible in a stainless steel canister to provide minimum void volume in the canister. The lead telluride thermoelectric elements are pressure-contacted to a tungsten hot strap and metallurgically bonded at the cold junction to iron shoes with a barrier layer of tin telluride between the iron shoe and the p-type lead telluride element.

Absence of metastable states in strained monoatomic cubic crystals.

NASA Astrophysics Data System (ADS)

Aguayo, Aarón; Mehl, Michael L.; de Coss, Romeo

2005-03-01

The Bain path distortion of a metal with an fcc (bcc) ground state toward the bcc (fcc) structure initially requires an increase in energy, but at some point along the Bain path the energy will again decrease until a local minimum is reached. We have studied the tetragonal distortion (Bain path) of monoatomic cubic crystals, using a combination of parametrized tight-binding and first-principles linearized augmented plane wave calculations. We show that this local minimum is unstable with respect to an elastic distortion, except in the rare case that the minimum is at the bcc (fcc) point on the Bain path. This shows that body-centered-tetragonal phases of these materials, which have been seen in epitaxially grown thin films, must be stabilized by the substrate and cannot be freestanding films. This work was partially supported by Consejo Nacional de Ciencia y Tecnolog'ia (CONACYT, M'exico) under Grant No. 43830-F.

Advanced Hydraulic Fracturing Technology for Unconventional Tight Gas Reservoirs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stephen Holditch; A. Daniel Hill; D. Zhu

2007-06-19

The objectives of this project are to develop and test new techniques for creating extensive, conductive hydraulic fractures in unconventional tight gas reservoirs by statistically assessing the productivity achieved in hundreds of field treatments with a variety of current fracturing practices ranging from 'water fracs' to conventional gel fracture treatments; by laboratory measurements of the conductivity created with high rate proppant fracturing using an entirely new conductivity test - the 'dynamic fracture conductivity test'; and by developing design models to implement the optimal fracture treatments determined from the field assessment and the laboratory measurements. One of the tasks of thismore » project is to create an 'advisor' or expert system for completion, production and stimulation of tight gas reservoirs. A central part of this study is an extensive survey of the productivity of hundreds of tight gas wells that have been hydraulically fractured. We have been doing an extensive literature search of the SPE eLibrary, DOE, Gas Technology Institute (GTI), Bureau of Economic Geology and IHS Energy, for publicly available technical reports about procedures of drilling, completion and production of the tight gas wells. We have downloaded numerous papers and read and summarized the information to build a database that will contain field treatment data, organized by geographic location, and hydraulic fracture treatment design data, organized by the treatment type. We have conducted experimental study on 'dynamic fracture conductivity' created when proppant slurries are pumped into hydraulic fractures in tight gas sands. Unlike conventional fracture conductivity tests in which proppant is loaded into the fracture artificially; we pump proppant/frac fluid slurries into a fracture cell, dynamically placing the proppant just as it occurs in the field. From such tests, we expect to gain new insights into some of the critical issues in tight gas fracturing, in particular the roles of gel damage, polymer loading (water-frac versus gel frac), and proppant concentration on the created fracture conductivity. To achieve this objective, we have designed the experimental apparatus to conduct the dynamic fracture conductivity tests. The experimental apparatus has been built and some preliminary tests have been conducted to test the apparatus.« less

Improvement of energy efficiency: the use of thermography and air-tightness test in verification of thermal performance of school buildings

NASA Astrophysics Data System (ADS)

Kauppinen, Timo; Siikanen, Sami

2011-05-01

The improvement of energy efficiency is the key issue after the energy performance of buildings directive came into the force in European Union countries. The city of Kuopio participate a project, in which different tools will be used, generated and tested to improve the energy efficiency of public buildings. In this project there are 2 schools, the other consuming much more heating energy than the other same type of school. In this paper the results of the thermography in normal conditions and under 50 Pa pressure drop will be presented; as well as the results of remote controlled air tightness test of the buildings. Thermography combined with air tightness test showed clearly the reasons of specific consumption differences of heating energy - also in the other hand, the measurements showed the problems in the performance of ventilation system. Thermography, air tightness test and other supporting measurements can be used together to solve energy loss problems - if these measurements will be carried out by proper way.

Edge currents in frustrated Josephson junction ladders

NASA Astrophysics Data System (ADS)

Marques, A. M.; Santos, F. D. R.; Dias, R. G.

2016-09-01

We present a numerical study of quasi-1D frustrated Josephson junction ladders with diagonal couplings and open boundary conditions, in the large capacitance limit. We derive a correspondence between the energy of this Josephson junction ladder and the expectation value of the Hamiltonian of an analogous tight-binding model, and show how the overall superconducting state of the chain is equivalent to the minimum energy state of the tight-binding model in the subspace of one-particle states with uniform density. To satisfy the constraint of uniform density, the superconducting state of the ladder is written as a linear combination of the allowed k-states of the tight-binding model with open boundaries. Above a critical value of the parameter t (ratio between the intra-rung and inter-rung Josephson couplings) the ladder spontaneously develops currents at the edges, which spread to the bulk as t is increased until complete coverage is reached. Above a certain value of t, which varies with ladder size (t = 1 for an infinite-sized ladder), the edge currents are destroyed. The value t = 1 corresponds, in the tight-binding model, to the opening of a gap between two bands. We argue that the disappearance of the edge currents with this gap opening is not coincidental, and that this points to a topological origin for these edge current states.

42 CFR 84.1142 - Isoamyl acetate tightness test; respirators designed for respiratory protection against dusts...

Code of Federal Regulations, 2013 CFR

2013-10-01

....1142 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust, Fume, and... 42 Public Health 1 2013-10-01 2013-10-01 false Isoamyl acetate tightness test; respirators...

42 CFR 84.1142 - Isoamyl acetate tightness test; respirators designed for respiratory protection against dusts...

Code of Federal Regulations, 2012 CFR

2012-10-01

....1142 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust, Fume, and... 42 Public Health 1 2012-10-01 2012-10-01 false Isoamyl acetate tightness test; respirators...

42 CFR 84.1142 - Isoamyl acetate tightness test; respirators designed for respiratory protection against dusts...

Code of Federal Regulations, 2011 CFR

2011-10-01

....1142 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust, Fume, and... 42 Public Health 1 2011-10-01 2011-10-01 false Isoamyl acetate tightness test; respirators...

42 CFR 84.1142 - Isoamyl acetate tightness test; respirators designed for respiratory protection against dusts...

Code of Federal Regulations, 2014 CFR

2014-10-01

....1142 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust, Fume, and... 42 Public Health 1 2014-10-01 2014-10-01 false Isoamyl acetate tightness test; respirators...

42 CFR 84.1142 - Isoamyl acetate tightness test; respirators designed for respiratory protection against dusts...

Code of Federal Regulations, 2010 CFR

2010-10-01

....1142 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust, Fume, and... 42 Public Health 1 2010-10-01 2010-10-01 false Isoamyl acetate tightness test; respirators...

Spark Plug Defects and Tests

NASA Technical Reports Server (NTRS)

Silsbee, F B; Loeb, L B; Sawyer, L G; Fonseca, E L; Dickinson, H C; Agnew, P G

1920-01-01

The successful operation of the spark plug depends to a large extent on the gas tightness of the plug. Part 1 of this report describes the method used for measuring the gas tightness of aviation spark plugs. Part 2 describes the methods used in testing the electrical conductivity of the insulation material when hot. Part 3 describes the testing of the cold dielectric strength of the insulation material, the resistance to mechanical shock, and the final engine test.

42 CFR 84.1141 - Isoamyl acetate tightness test; dust, fume, and mist respirators designed for respiratory...

Code of Federal Regulations, 2013 CFR

2013-10-01

... Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust, Fume, and Mist... 42 Public Health 1 2013-10-01 2013-10-01 false Isoamyl acetate tightness test; dust, fume, and...

42 CFR 84.1141 - Isoamyl acetate tightness test; dust, fume, and mist respirators designed for respiratory...

Code of Federal Regulations, 2010 CFR

2010-10-01

... Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust, Fume, and Mist... 42 Public Health 1 2010-10-01 2010-10-01 false Isoamyl acetate tightness test; dust, fume, and...

42 CFR 84.1141 - Isoamyl acetate tightness test; dust, fume, and mist respirators designed for respiratory...

Code of Federal Regulations, 2014 CFR

2014-10-01

... Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust, Fume, and Mist... 42 Public Health 1 2014-10-01 2014-10-01 false Isoamyl acetate tightness test; dust, fume, and...

42 CFR 84.1141 - Isoamyl acetate tightness test; dust, fume, and mist respirators designed for respiratory...

Code of Federal Regulations, 2012 CFR

2012-10-01

... Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust, Fume, and Mist... 42 Public Health 1 2012-10-01 2012-10-01 false Isoamyl acetate tightness test; dust, fume, and...

42 CFR 84.1141 - Isoamyl acetate tightness test; dust, fume, and mist respirators designed for respiratory...

Code of Federal Regulations, 2011 CFR

2011-10-01

... Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust, Fume, and Mist... 42 Public Health 1 2011-10-01 2011-10-01 false Isoamyl acetate tightness test; dust, fume, and...

Hydrologic testing of tight zones in southeastern New Mexico.

USGS Publications Warehouse

Dennehy, K.F.; Davis, P.A.

1981-01-01

Increased attention is being directed toward the investigation of tight zones in relation to the storage and disposal of hazardous wastes. Shut-in tests, slug tests, and pressure-slug tests are being used at the proposed Waste Isolation Pilot Plant site, New Mexico, to evaluate the fluid-transmitting properties of several zones above the proposed repository zone. All three testing methods were used in various combinations to obtain values for the hydraulic properties of the test zones. Multiple testing on the same zone produced similar results. -from Authors

An Objective Measure of Noseband Tightness and Its Measurement Using a Novel Digital Tightness Gauge.

PubMed

Doherty, Orla; Conway, Thomas; Conway, Richard; Murray, Gerard; Casey, Vincent

2017-01-01

Noseband tightness is difficult to assess in horses participating in equestrian sports such as dressage, show jumping and three-day-eventing. There is growing concern that nosebands are commonly tightened to such an extent as to restrict normal equine behaviour and possibly cause injury. In the absence of a clear agreed definition of noseband tightness, a simple model of the equine nose-noseband interface environment was developed in order to guide further studies in this area. The normal force component of the noseband tensile force was identified as the key contributor to sub-noseband tissue compression. The model was used to inform the design of a digital tightness gauge which could reliably measure the normal force component of the noseband tensile force. A digital tightness gauge was developed to measure this parameter under nosebands fitted to bridled horses. Results are presented for field tests using two prototype designs. Prototype version three was used in field trial 1 (n = 15, frontal nasal plane sub-noseband site). Results of this trial were used to develop an ergonomically designed prototype, version 4, which was tested in a second field trial (n = 12, frontal nasal plane and lateral sub-noseband site). Nosebands were set to three tightness settings in each trial as judged by a single rater using an International Society for Equitation Science (ISES) taper gauge. Normal forces in the range 7-95 N were recorded at the frontal nasal plane while a lower range 1-28 N was found at the lateral site for the taper gauge range used in the trials. The digital tightness gauge was found to be simple to use, reliable, and safe and its use did not agitate the animals in any discernable way. A simple six point tightness scale is suggested to aid regulation implementation and the control of noseband tightness using normal force measurement as the objective tightness discriminant.

Contextual Advantage for State Discrimination

NASA Astrophysics Data System (ADS)

Schmid, David; Spekkens, Robert W.

2018-02-01

Finding quantitative aspects of quantum phenomena which cannot be explained by any classical model has foundational importance for understanding the boundary between classical and quantum theory. It also has practical significance for identifying information processing tasks for which those phenomena provide a quantum advantage. Using the framework of generalized noncontextuality as our notion of classicality, we find one such nonclassical feature within the phenomenology of quantum minimum-error state discrimination. Namely, we identify quantitative limits on the success probability for minimum-error state discrimination in any experiment described by a noncontextual ontological model. These constraints constitute noncontextuality inequalities that are violated by quantum theory, and this violation implies a quantum advantage for state discrimination relative to noncontextual models. Furthermore, our noncontextuality inequalities are robust to noise and are operationally formulated, so that any experimental violation of the inequalities is a witness of contextuality, independently of the validity of quantum theory. Along the way, we introduce new methods for analyzing noncontextuality scenarios and demonstrate a tight connection between our minimum-error state discrimination scenario and a Bell scenario.

Determination of Urea Permeability in Red Cells by Minimum Method

PubMed Central

Sha'afi, R. I.; Rich, G. T.; Mikulecky, D. C.; Solomon, A. K.

1970-01-01

A new method has been developed for measuring the permeability coefficient, ω, of small nonelectrolytes. The method depends upon a mathematical analysis of the time course of cell volume changes in the neighborhood of the minimum volume following addition of a permeating solute to an isosmolal buffer. Coefficients determined by the minimum volume method agree with those obtained using radioactive tracers. ω for urea in human red cells was found to decrease as the volume flow, Jv, into the cell increased. Such behavior is entirely unexpected for a single uniform rate-limiting barrier on the basis of the linear phenomenological equations derived from irreversible thermodynamics. However, the present findings are consonant with a complex membrane system consisting of a tight barrier on the outer face of the human red cell membrane and a somewhat less restrictive barrier behind it closer to the inner membrane face. A theoretical analysis of such a series model has been made which makes predictions consistent with the experimental findings. PMID:5435779

Fluctuation Pressure Assisted Ejection of DNA From Bacteriophage

NASA Astrophysics Data System (ADS)

Harrison, Michael J.

2011-03-01

The role of thermal pressure fluctuations excited within tightly packaged DNA while it is ejected from protein capsid shells is discussed in a model calculation. At equilibrium before ejection we assume the DNA is folded many times into a bundle of parallel segments that forms an equilibrium conformation at minimum free energy, which presses tightly against capsid walls. Using a canonical ensemble at temperature T we calculate internal pressure fluctuations against a slowly moving or static capsid mantle for an elastic continuum model of the folded DNA bundle. It is found that fluctuating pressures on the capsid from thermal excitation of longitudinal acoustic vibrations in the bundle whose wavelengths are exceeded by the bend persistence length may have root-mean-square values that are several tens of atmospheres for typically small phage dimensions. Comparisons are given with measured data on three mutants of lambda phage with different base pair lengths and total genome ejection pressures.

Preliminary engineering study: Quick opening valve MSFC high Reynolds number wind tunnel

NASA Technical Reports Server (NTRS)

1983-01-01

FluiDyne Engineering Corporation has conducted a preliminary engineering study of a quick-opening valve for the MSFC High Reynolds Number Wind Tunnel under NASA Contract NAS8-35056. The subject valve is intended to replace the Mylar diaphragm system as the flow initiation device for the tunnel. Only valves capable of opening within 0.05 sec. and providing a minimum of 11.4 square feet of flow area were considered. Also, the study focused on valves which combined the quick-opening and tight shutoff features in a single unit. A ring sleeve valve concept was chosen for refinement and pricing. Sealing for tight shutoff, ring sleeve closure release and sleeve actuation were considered. The resulting cost estimate includes the valve and requisite modifications to the facility to accommodate the valve as well as the associated design and development work.

Method for quick thermal tolerancing of optical systems

NASA Astrophysics Data System (ADS)

Werschnik, J.; Uhlendorf, K.

2016-09-01

Optical systems for lithography (projection lens), inspection (micro-objectives) or laser material processing usually have tight specifications regarding focus and wave-front stability. The same is true regarding the field dependent properties. Especially projection lenses have tight specifications on field curvature, magnification and distortion. Unwanted heating either from internal or external sources lead to undesired changes of the above properties. In this work we show an elegant and fast method to analyze the thermal sensitivity using ZEMAX. The key point of this method is using the thermal changes of the lens data from the multi-configuration editor as starting point for a (standard) tolerance analysis. Knowing the sensitivity we can either define requirements on the environment or use it to systematically improve the thermal behavior of the lens. We demonstrate this method for a typical projection lens for which we optimized the thermal field curvature to a minimum.

Design and rationale of Heart and Lung Failure – Pediatric INsulin Titration Trial (HALF-PINT): A randomized clinical trial of tight glycemic control in hyperglycemic critically ill children☆

PubMed Central

Agus, Michael SD; Hirshberg, Ellie; Srinivasan, Vijay; Faustino, Edward Vincent; Luckett, Peter M; Curley, Martha AQ; Alexander, Jamin; Asaro, Lisa A; Coughlin-Wells, Kerry; Duva, Donna; French, Jaclyn; Hasbani, Natalie; Sisko, Martha T; Soto-Rivera, Carmen L; Steil, Garry; Wypij, David; Nadkarni, Vinay M

2017-01-01

Objectives Test whether hyperglycemic critically ill children with cardiovascular and/or respiratory failure experience more ICU-free days when assigned to tight glycemic control with a normoglycemic versus hyperglycemic blood glucose target range. Design Multi-center randomized clinical trial. Setting Pediatric ICUs at 35 academic hospitals. Patients Children aged 2 weeks to 17 years receiving inotropic support and/or acute mechanical ventilation, excluding cardiac surgical patients. Interventions Patients receive intravenous insulin titrated to either 80–110 mg/dL (4.4–6.1 mmol/L) or 150–180 mg/dL (8.3–10.0 mmol/L). The intervention begins upon confirmed hyperglycemia and ends when the patient meets study-defined ICU discharge criteria or after 28 days. Continuous glucose monitoring, a minimum glucose infusion, and an explicit insulin infusion algorithm are deployed to achieve the BG targets while minimizing hypoglycemia risk. Measurements and main results The primary outcome is ICU-free days (equivalent to 28-day hospital mortality-adjusted ICU length of stay). Secondary outcomes include 90-day hospital mortality, organ dysfunction scores, ventilator-free days, nosocomial infection rate, neurodevelopmental outcomes, and nursing workload. To detect an increase of 1.25 ICU-free days (corresponding to a 20% relative reduction in 28-day hospital mortality and a one-day reduction in ICU length of stay), 1414 patients are needed for 80% power using a two-sided 0.05 level test. Conclusions This trial tests whether hyperglycemic critically ill children randomized to 80–110 mg/dL benefit more than those randomized to 150–180 mg/dL. This study implements validated bedside support tools including continuous glucose monitoring and a computerized algorithm to enhance patient safety and ensure reproducible bedside decision-making in achieving glycemic control. PMID:28042054

Tight Placement of Erich Arch Bar While Avoiding Wire Fatigue Failure.

PubMed

Kirk, Daniel; Whitney, Joseph; Shafer, David; Song, Liansheng

2016-03-01

To determine the number of wire twists needed to acquire ideal Erich arch bar tightness before wire fatigue failure (fracture) in relation to different distances and angles at which different gauge wires are grasped to provide information to improve the efficiency of arch bar application. This study mimicked surgical placement of arch bars with 24- and 26-gauge wires. The number of twists to tightness and failure was evaluated when the wire distance between the arch bar and wire holder tip changed (5 vs 10 mm) and when the degree at which the wire was held relative to the tooth axis was changed (45° vs 90°). A wire shearing test also was used to investigate the fatigability of wires tightened under these same conditions. Wires twisted to tightness, past tightness, and after shearing test movements were visualized with electron microscopy. For 24-gauge wire held at 5 mm, 2.6 to 2.8 twists were needed for wire tightness, with failure after 1.7 to 1.9 twists past tightness; for 24-gauge wire held at 10 mm, 4.4 to 4.9 twists produced tightness, with failure after 2.3 to 2.9 twists past tightness. For 26-gauge wire held at 5 mm, 3.3 to 3.5 twists provided tightness, with 1.6 to 1.8 twists past tightness causing failure; for 26-gauge wire held at 10 mm, 5.1 to 5.5 twists produced tightness, with 3.1 to 3.7 twists past tightness causing failure. At a 45° angle, the wire tightened with fewer twists and showed more resistance to failure with twists past tightness compared with 90° using 24- and 26-gauge wires. In contrast, 24-gauge wire held at a 5-mm distance showed the opposite result, with decreased resistance to failure at the 45° angle. However, the differences were not statistically meaningful. Scanning election microscopy showed no wire fatigue for either angle for 26-gauge wire held at a 5-mm distance and twisted to tightness. After overtightening and oscillation, the 90° angle trials showed fatigue, whereas the 45° angle trials did not. Holding a 24-gauge wire at 45° to the tooth axis is recommended owing to fewer twists to tightness and more resistance to failure. A 5-mm grasping distance is recommended for experienced surgeons owing to fewer twists to tightness, whereas a 10-mm grasping distance is recommended for novice surgeons owing to a greater tolerance for over-twisting before failure. Copyright © 2016 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

A tightly-coupled domain-decomposition approach for highly nonlinear stochastic multiphysics systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Taverniers, Søren; Tartakovsky, Daniel M., E-mail: dmt@ucsd.edu

2017-02-01

Multiphysics simulations often involve nonlinear components that are driven by internally generated or externally imposed random fluctuations. When used with a domain-decomposition (DD) algorithm, such components have to be coupled in a way that both accurately propagates the noise between the subdomains and lends itself to a stable and cost-effective temporal integration. We develop a conservative DD approach in which tight coupling is obtained by using a Jacobian-free Newton–Krylov (JfNK) method with a generalized minimum residual iterative linear solver. This strategy is tested on a coupled nonlinear diffusion system forced by a truncated Gaussian noise at the boundary. Enforcement ofmore » path-wise continuity of the state variable and its flux, as opposed to continuity in the mean, at interfaces between subdomains enables the DD algorithm to correctly propagate boundary fluctuations throughout the computational domain. Reliance on a single Newton iteration (explicit coupling), rather than on the fully converged JfNK (implicit) coupling, may increase the solution error by an order of magnitude. Increase in communication frequency between the DD components reduces the explicit coupling's error, but makes it less efficient than the implicit coupling at comparable error levels for all noise strengths considered. Finally, the DD algorithm with the implicit JfNK coupling resolves temporally-correlated fluctuations of the boundary noise when the correlation time of the latter exceeds some multiple of an appropriately defined characteristic diffusion time.« less

Understanding ethylammonium nitrate stabilized cytochrome c - Molecular dynamics and experimental approach

NASA Astrophysics Data System (ADS)

Jaganathan, Maheshkumar; Ramakrishnan, C.; Velmurugan, D.; Dhathathreyan, Aruna

2015-02-01

For a conceptual understanding of how an ionic liquid stabilizes a solvated protein, in this study, using new force field parameters, a molecular dynamics simulation (MDS) of the loop and helical regions of hydrated Cytochrome c (cyt c) and its interaction with the ionic liquid ethylammonium nitrate (EAN) have been studied. For a simulation trajectory of 100 ns, the changes in network of water around the protein due to EAN and subsequent reorganization of the protein have been analyzed. The radii of gyration of solvated cyt c (13.7 Å) and cyt c + EAN (13.4 Å) at the end of the trajectory are higher than the protein in its crystalline state (12.64 Å) suggesting enhanced stability of the protein due to tightly organized assembly of EAN near the solvated cyt c. This increase in stability of the protein has been verified experimentally using fluorescence, circular dichroic spectroscopy and differential scanning calorimetry. With increasing EAN in cyt c + EAN, protein conformation shows unusually high β strand population. To check whether the beta strand is an intermediate or a local minimum state, denaturation of cyt c with urea in the presence of EAN has been undertaken. Results show that EAN helps in renaturation of the protein by forming a tightly organized assembly around the protein with the beta strand state appearing as a local minimum energy state. Thus the feasibility of using ionic liquids to form networks around the protein and their possible applications in stabilization of the proteins has been demonstrated.

Well test mathematical model for fractures network in tight oil reservoirs

NASA Astrophysics Data System (ADS)

Diwu, Pengxiang; Liu, Tongjing; Jiang, Baoyi; Wang, Rui; Yang, Peidie; Yang, Jiping; Wang, Zhaoming

2018-02-01

Well test, especially build-up test, has been applied widely in the development of tight oil reservoirs, since it is the only available low cost way to directly quantify flow ability and formation heterogeneity parameters. However, because of the fractures network near wellbore, generated from artificial fracturing linking up natural factures, traditional infinite and finite conductivity fracture models usually result in significantly deviation in field application. In this work, considering the random distribution of natural fractures, physical model of fractures network is proposed, and it shows a composite model feature in the large scale. Consequently, a nonhomogeneous composite mathematical model is established with threshold pressure gradient. To solve this model semi-analytically, we proposed a solution approach including Laplace transform and virtual argument Bessel function, and this method is verified by comparing with existing analytical solution. The matching data of typical type curves generated from semi-analytical solution indicates that the proposed physical and mathematical model can describe the type curves characteristic in typical tight oil reservoirs, which have up warping in late-term rather than parallel lines with slope 1/2 or 1/4. It means the composite model could be used into pressure interpretation of artificial fracturing wells in tight oil reservoir.

Vacancy Mediated Mechanism of Nitrogen Substitution in Carbon Nanotubes

NASA Technical Reports Server (NTRS)

Srivastava, Deepak; Menon, Madhu; Sadanadan, Bindu; Rao, Apparao M.

2003-01-01

Nitrogen substitution reaction in a graphene sheet and carbon nanotubes of different diameter are investigated using the generalized tight-binding molecular dynamics method. The formation of a vacancy in curved graphene sheet or a carbon nanotube is found to cause a curvature dependent local reconstruction of the surface. Our simulations and analysis show that vacancy mediated N substitution (rather than N chemisorption) is favored on the surface of nanotubes with diameter larger than 8 nm. This predicted value of the critical minimum diameter for N incorporation is confirmed by experimental results presented.

ELECTRICAL COIL STRUCTURE

DOEpatents

Baker, W.R.; Hartwig, A.

1962-09-25

A compactly wound electrical coil is designed for carrying intense pulsed currents such as are characteristic of controlled thermonuclear reaction devices. A flat strip of conductor is tightly wound in a spiral with a matching flat strip of insulator. To provide for a high fluid coolant flow through the coil with minimum pumping pressure, a surface of the conductor is scored with parallel transverse grooves which form short longitudinal coolant pasaages when the conductor is wound in the spiral configuration. Owing to this construction, the coil is extremely resistant to thermal and magnetic shock from sudden high currents. (AEC)

The presence and influence of posterior capsule tightness on different shoulder problems.

PubMed

Duzgun, Irem; Turgut, Elif; Çinar-Medeni, Özge; Kafa, Nihan; Tuna, Zeynep; Elbasan, Bulent; Oskay, Deran

2017-01-01

In the literature it has been shown that posterior capsule flexibility is a precursor to shoulder problems. However, no study thus far has shown the influence of the flexibility of posterior capsule in different shoulder pathologies. This study set about to compare the role of posterior capsule tightness in different shoulder problems. One-hundred-twenty-five patients diagnosed with shoulder subacromial impingement syndrome (n= 52), partial rotator cuff tear (n= 31) or frozen shoulder (n= 42) and 30 asymptomatic peers participated in the study. Horizontal adduction was assessed in side-lying position for posterior capsule tightness. Pain was measured via the visual analogue scale and shoulder range of motion and active total elevation was assessed with goniometer. Hand behind the back (HBB) test was assessed the active internal rotation by measuring the distance between T5 and the thumb. It was found that the affected side of the posterior capsules of the patients with subacromial impingement syndrome (p< 0.001), partial rotator cuff tear (p< 0.001) and frozen shoulder (p< 0.001) was stiffer than their healthy side. There were significant differences among groups in the level of tightness in the posterior capsule between the affected and the healthy sides (p< 0.001). All range of motion of the shoulder including HBB test and the posterior capsule tightness of the affected side are found to be correlated (p< 0.05). This study emphasized that the posterior capsule's susceptibility to tightness is most evident in frozen shoulder among different shoulder problems.

Investigating Low Temperature Properties of Rubber Seals - 13020

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jaunich, M.; Wolff, D.; Stark, W.

To achieve the required tightness levels of containers for low and intermediate level radioactive wastes rubbers are widely applied as main sealing materials. The save encapsulation of the radioactive container contents has to be guaranteed according to legislation and appropriate guidelines for long storage periods as well as down to temperatures of -40 deg. C during transportation. Therefore the understanding of failure mechanisms that lead to leakage at low temperatures is of high importance. It is known that the material properties of rubbers are strongly influenced by temperature. At low temperatures this is caused by the rubber-glass transition (abbr. glassmore » transition). During continuous cooling the material changes from rubber-like entropy-elastic to stiff energy-elastic behaviour, that allows nearly no strain or retraction. Therefore, rubbers are normally used above their glass transition but the minimum working temperature limit is not defined precisely, what can cause problems during application. The temperature range where full functionality is possible is strongly dependent on the application conditions and the material. For this investigation mainly ethylene propylene diene (EPDM) and fluorocarbon rubbers (FKM) were selected as they are often used for radioactive waste containers. Differential Scanning Calorimetry (DSC) and Dynamic Mechanical Analysis (DMA) are typically used for the determination of the temperature range of the glass transition process. The standardized compression set measurement according to ISO 815 is common for investigation of rubber sealing materials as the test simulates the seal behaviour after release. To reduce the test time of the standard tests a faster technique giving the same information was developed. Additionally, the breakdown temperature of the sealing function of complete O-ring seals is measured in a component test setup to compare it with the results of the other tests. The experimental setup is capable of measuring the leakage rate at low temperatures by the pressure rise method. A model was developed that allows calculating the minimum working temperature limit of a seal by combining the results of the applied methods. (authors)« less

Keeping Schools Safe during Tight Budget Times

ERIC Educational Resources Information Center

Trump, Kenneth S.

2010-01-01

Tight budgets are no excuse for failing to be proactive with school safety. In fact, school leaders must be especially committed to prevention and security programs during times when economic woes are increasing stress on kids, their families and school staff. Parents will forgive educators if their school's test scores drop. But they are much…

JAM-C regulates tight junctions and integrin-mediated cell adhesion and migration.

PubMed

Mandicourt, Guillaume; Iden, Sandra; Ebnet, Klaus; Aurrand-Lions, Michel; Imhof, Beat A

2007-01-19

Junctional Adhesion Molecules (JAMs) have been described as major components of tight junctions in endothelial and epithelial cells. Tight junctions are crucial for the establishment and maintenance of cell polarity. During tumor development, they are remodeled, enabling neoplastic cells to escape from constraints imposed by intercellular junctions and to adopt a migratory behavior. Using a carcinoma cell line we tested whether JAM-C could affect tight junctions and migratory properties of tumor cells. We show that transfection of JAM-C improves the tight junctional barrier in tumor cells devoid of JAM-C expression. This is dependent on serine 281 in the cytoplasmic tail of JAM-C because serine mutation into alanine abolishes the specific localization of JAM-C in tight junctions and establishment of cell polarity. More importantly, the same mutation stimulates integrin-mediated cell migration and adhesion via the modulation of beta1 and beta3 integrin activation. These results highlight an unexpected function for JAM-C in controlling epithelial cell conversion from a static, polarized state to a pro-migratory phenotype.

High-Precision Image Aided Inertial Navigation with Known Features: Observability Analysis and Performance Evaluation

PubMed Central

Jiang, Weiping; Wang, Li; Niu, Xiaoji; Zhang, Quan; Zhang, Hui; Tang, Min; Hu, Xiangyun

2014-01-01

A high-precision image-aided inertial navigation system (INS) is proposed as an alternative to the carrier-phase-based differential Global Navigation Satellite Systems (CDGNSSs) when satellite-based navigation systems are unavailable. In this paper, the image/INS integrated algorithm is modeled by a tightly-coupled iterative extended Kalman filter (IEKF). Tightly-coupled integration ensures that the integrated system is reliable, even if few known feature points (i.e., less than three) are observed in the images. A new global observability analysis of this tightly-coupled integration is presented to guarantee that the system is observable under the necessary conditions. The analysis conclusions were verified by simulations and field tests. The field tests also indicate that high-precision position (centimeter-level) and attitude (half-degree-level)-integrated solutions can be achieved in a global reference. PMID:25330046

Nonlinear Thomson scattering of a relativistically strong tightly focused ultrashort laser pulse

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vais, O. E.; Bochkarev, S. G., E-mail: bochkar@sci.lebedev.ru; Bychenkov, V. Yu.

The problem of nonlinear Thomson scattering of a relativistically strong linearly polarized ultrashort laser pulse tightly focused into a spot with a diameter of D{sub F} ≳ λ (where λ is the laser wavelength) is solved. The energy, spectral, and angular distributions of radiation generated due to Thomson scattering from test electrons located in the focal region are found. The characteristics of scattered radiation are studied as functions of the tightness of laser focusing and the initial position of test particles relative to the center of the focal region for a given laser pulse energy. It is demonstrated that themore » ultratight focusing is not optimal for obtaining the brightest and hardest source of secondary electromagnetic radiation. The hardest and shortest radiation pulse is generated when the beam waist diameter is ≃10λ.« less

Spin correlations and entanglement in partially magnetised ensembles of fermions

NASA Astrophysics Data System (ADS)

Thekkadath, G. S.; Jiang, Liang; Thywissen, J. H.

2016-11-01

We show that the singlet fraction p s and total magnetisation (or polarisation) m can bound the minimum concurrence in an ensemble of spins. We identify {p}{{s}}\\gt (1-{m}2)/2 as a sufficient and tight condition for bipartite entanglement. Our proof makes no assumptions about the state of the system or symmetry of the particles, and can therefore be used as a witness for spin entanglement between fermions. We discuss the implications for recent experiments in which spin correlations were observed, and the prospect to study entanglement dynamics in the demagnetisation of a cold Fermi gas.

The Role of Synthetic Reconstruction Tests in Seismic Tomography

NASA Astrophysics Data System (ADS)

Rawlinson, N.; Spakman, W.

2015-12-01

Synthetic reconstruction tests are widely used in seismic tomography as a means for assessing the robustness of solutions produced by linear or iterative non-linear inversion schemes. The most common test is the so-called checkerboard resolution test, which uses an alternating pattern of high and low wavespeeds (or some other seismic property such as attenuation). However, checkerboard tests have a number of limitations, including that they (1) only provide indirect evidence of quantitative measures of reliability such as resolution and uncertainty; (2) give a potentially misleading impression of the range of scale-lengths that can be resolved; (3) don't give a true picture of the structural distortion or smearing caused by the data coverage; and (4) result in an inverse problem that is biased towards an accurate reconstruction. The widespread use of synthetic reconstruction tests in seismic tomography is likely to continue for some time yet, so it is important to implement best practice where possible. The goal here is to provide a general set of guidelines, derived from the underlying theory and illustrated by a series of numerical experiments, on their implementation in seismic tomography. In particular, we recommend (1) using a sparse distribution of spikes, rather than the more conventional tightly-spaced checkerboard; (2) using the identical data coverage (e.g. geometric rays) for the synthetic model that was computed for the observation-based model; (3) carrying out multiple tests using anomalies of different scale length; (4) exercising caution when analysing synthetic recovery tests that use anomaly patterns that closely mimic the observation-based model; (5) investigating the trade-off between data noise levels and the minimum wavelength of recovered structure; (6) where possible, test the extent to which preconditioning (e.g. identical parameterization for input and output models) influences the recovery of anomalies.

76 FR 80781 - Alcohol and Drug Testing: Determination of Minimum Random Testing Rates for 2012

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-27

...-11213, Notice No. 15] RIN 2130-AA81 Alcohol and Drug Testing: Determination of Minimum Random Testing.... According to data from FRA's Management Information System, the rail industry's random drug testing [[Page... Administrator (Administrator) has therefore determined that the minimum annual random drug testing rate for the...

77 FR 75896 - Alcohol and Drug Testing: Determination of Minimum Random Testing Rates for 2013

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-26

...-11213, Notice No. 16] Alcohol and Drug Testing: Determination of Minimum Random Testing Rates for 2013... from FRA's Management Information System, the rail industry's random drug testing positive rate has... therefore determined that the minimum annual random drug testing rate for the period January 1, 2013...

Development of a Multicenter Density Functional Tight Binding Model for Plutonium Surface Hydriding.

PubMed

Goldman, Nir; Aradi, Bálint; Lindsey, Rebecca K; Fried, Laurence E

2018-05-08

We detail the creation of a multicenter density functional tight binding (DFTB) model for hydrogen on δ-plutonium, using a framework of new Slater-Koster interaction parameters and a repulsive energy based on the Chebyshev Interaction Model for Efficient Simulation (ChIMES), where two- and three-center atomic interactions are represented by linear combinations of Chebyshev polynomials. We find that our DFTB/ChIMES model yields a total electron density of states for bulk δ-Pu that compares well to that from Density Functional Theory, as well as to a grid of energy calculations representing approximate H 2 dissociation paths on the δ-Pu (100) surface. We then perform molecular dynamics simulations and minimum energy pathway calculations to determine the energetics of surface dissociation and subsurface diffusion on the (100) and (111) surfaces. Our approach allows for the efficient creation of multicenter repulsive energies with a relatively small investment in initial DFT calculations. Our efforts are particularly pertinent to studies that rely on quantum calculations for interpretation and validation, such as experimental determination of chemical reactivity both on surfaces and in condensed phases.

Experimental Test of Entropic Noise-Disturbance Uncertainty Relations for Spin-1/2 Measurements.

PubMed

Sulyok, Georg; Sponar, Stephan; Demirel, Bülent; Buscemi, Francesco; Hall, Michael J W; Ozawa, Masanao; Hasegawa, Yuji

2015-07-17

Information-theoretic definitions for noise and disturbance in quantum measurements were given in [Phys. Rev. Lett. 112, 050401 (2014)] and a state-independent noise-disturbance uncertainty relation was obtained. Here, we derive a tight noise-disturbance uncertainty relation for complementary qubit observables and carry out an experimental test. Successive projective measurements on the neutron's spin-1/2 system, together with a correction procedure which reduces the disturbance, are performed. Our experimental results saturate the tight noise-disturbance uncertainty relation for qubits when an optimal correction procedure is applied.

Optimizing the Timing Resolution for the NEXT Array

NASA Astrophysics Data System (ADS)

Engelhardt, A.; Shadrick, S.; Rajabali, M.; Schmitt, K.; Grzywacz, R.

2016-09-01

In nuclear physics studies there are very few detectors capable of measuring neutron energies in the 0.1-10 MeV energy range with a reasonable resolution. The VANDLE array is the premier detector array for these measurements, yet VANDLE is limited by the its thickness (2.9 cm minimum).The Neutron dEtector with Tracking (NEXT) array would be capable of surpassing the limitations caused by the large size of VANDLE bars. A proposed configuration of each neutron detector consists of ten 3-mm thick plastic scintillators with two or more silicon photomultipliers (SiPMs) attached at each end. To achieve the desired energy resolution for neutron energy measurements through time of flight, the timing resolution between these SiPMs needs to be below 200 ps. A SiPM was placed on each end of a plastic scintillator inside a light-tight electrical box along with a 137Cs source. An analog circuit was designed in order to measure the timing difference between the two SiPMs. Different configurations of SiPM sizes, scintillator sizes, and wrappings were tested in order to determine the configuration that yields the best timing resolution. Details of the testing procedures and results will be presented. Research Supported by the National Nuclear Security Administration.

Characteristics of secondary migration driving force of tight oil and its geologic effect: a case study of Jurassic in Central Sichuan Basin

NASA Astrophysics Data System (ADS)

Pang, Zhenglian; Tao, Shizhen; Zhang, Bin; Wu, Songtao; Yang, Jiajing; Chen, Ruiyin

2017-04-01

As the rising of its production, tight oil is becoming more and more important. Much research has been done about it. Some articles mention that buoyancy is ineffective for tight oil secondary migration, and abnormal pressure is the alternative. Others believe that overpressure caused hydrocarbon generation is the very force. Though opinions have been given, there are two inadequacies. Firstly, the points are lack of sufficient evidences. Mostly, they are only one or two sentences in the papers. Secondly, geologic effect of the change of driving force hasn't been discussed. In this context, analog experiments, physical property testing, mercury injection, and oil/source comparison were utilized to study 3 issues: origin and value of tight oil secondary migration resistance, values and effectiveness of different potential driving forces, and geologic effect of tight oil secondary migration driving force. Firstly, resistance values of tight reservoir were detected by analog experiments. The value of tight limestone is 15.8MPa, while tight sandstone is 10.7MPa. Tiny size of pores and throats in tight reservoir is the main reason causing huge resistances. Over 90% of pores and throats in tight reservoir are smaller than 1μm. They form huge capillary force when oil migrating through them. Secondly, maximum of buoyancy in study area was confirmed, 0.09MPa, too small to overcome the resistances. Meanwhile, production data suggests that tight oil distribution pattern is not controlled by buoyancy. Conversely, analog experiment proves that overpressure caused by hydrocarbon generation can reach 38MPa, large enough to be the driving force. This idea is also supported by positive correlation between output and source rock formation pressure. Thirdly, is the geologic effect of tight oil secondary migration resistance and driving force. Tight oil can migrate only as non-darcy flow due to huge resistances according to percolation experiments. It needs to overcome the starting pressure gradient. As a result, it migrated a much shorter distance compared with conventional petroleum, coincident with the result of oil/source comparison. The effect of driving force is that boundary of tight oil profitable area is controlled by source rock. This boundary in the study area is the line of hydrocarbon generating strength of 40×104t/km2. By confirming controlling factors of tight oil formation and their evaluation index, it is of great significance during tight oil exploration.

Computing Bounds on Resource Levels for Flexible Plans

NASA Technical Reports Server (NTRS)

Muscvettola, Nicola; Rijsman, David

2009-01-01

A new algorithm efficiently computes the tightest exact bound on the levels of resources induced by a flexible activity plan (see figure). Tightness of bounds is extremely important for computations involved in planning because tight bounds can save potentially exponential amounts of search (through early backtracking and detection of solutions), relative to looser bounds. The bound computed by the new algorithm, denoted the resource-level envelope, constitutes the measure of maximum and minimum consumption of resources at any time for all fixed-time schedules in the flexible plan. At each time, the envelope guarantees that there are two fixed-time instantiations one that produces the minimum level and one that produces the maximum level. Therefore, the resource-level envelope is the tightest possible resource-level bound for a flexible plan because any tighter bound would exclude the contribution of at least one fixed-time schedule. If the resource- level envelope can be computed efficiently, one could substitute looser bounds that are currently used in the inner cores of constraint-posting scheduling algorithms, with the potential for great improvements in performance. What is needed to reduce the cost of computation is an algorithm, the measure of complexity of which is no greater than a low-degree polynomial in N (where N is the number of activities). The new algorithm satisfies this need. In this algorithm, the computation of resource-level envelopes is based on a novel combination of (1) the theory of shortest paths in the temporal-constraint network for the flexible plan and (2) the theory of maximum flows for a flow network derived from the temporal and resource constraints. The measure of asymptotic complexity of the algorithm is O(N O(maxflow(N)), where O(x) denotes an amount of computing time or a number of arithmetic operations proportional to a number of the order of x and O(maxflow(N)) is the measure of complexity (and thus of cost) of a maximumflow algorithm applied to an auxiliary flow network of 2N nodes. The algorithm is believed to be efficient in practice; experimental analysis shows the practical cost of maxflow to be as low as O(N1.5). The algorithm could be enhanced following at least two approaches. In the first approach, incremental subalgorithms for the computation of the envelope could be developed. By use of temporal scanning of the events in the temporal network, it may be possible to significantly reduce the size of the networks on which it is necessary to run the maximum-flow subalgorithm, thereby significantly reducing the time required for envelope calculation. In the second approach, the practical effectiveness of resource envelopes in the inner loops of search algorithms could be tested for multi-capacity resource scheduling. This testing would include inner-loop backtracking and termination tests and variable and value-ordering heuristics that exploit the properties of resource envelopes more directly.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Granderson, G.D.

The purpose of the dissertation is to examine the impact of rate-of-return regulation on the cost of transporting natural gas in interstate commerce. Of particular interest is the effect of the regulation on the input choice of a firm. Does regulation induce a regulated firm to produce its selected level of output at greater than minimum cost The theoretical model is based on the work of Rolf Faere and James Logan who investigate the duality relationship between the cost and production functions of a rate-of-return regulated firm. Faere and Logan derive the cost function for a regulated firm as themore » minimum cost of producing the firm's selected level of output, subject to the regulatory constraint. The regulated cost function is used to recover the unregulated cost function. A firm's unregulated cost function is the minimum cost of producing its selected level of output. Characteristics of the production technology are obtained from duality between the production and unregulated cost functions. Using data on 20 pipeline companies from 1977 to 1987, the author estimates a random effects model that consists of a regulated cost function and its associated input share equations. The model is estimated as a set of seemingly unrelated regressions. The empirical results are used to test the Faere and Logan theory and the traditional Averch-Johnson hypothesis of overcapitalization. Parameter estimates are used to recover the unregulated cost function and to calculate the amount by which transportation costs are increased by the regulation of the industry. Empirical results show that a firm's transportation cost decreases as the allowed rate of return increases and the regulatory constraint becomes less tight. Elimination of the regulatory constraint would lead to a reduction in costs on average of 5.278%. There is evidence that firms overcapitalize on pipeline capital. There is inconclusive evidence on whether firms overcapitalized on compressor station capital.« less

Loose and Tight GNSS/INS Integrations: Comparison of Performance Assessed in Real Urban Scenarios.

PubMed

Falco, Gianluca; Pini, Marco; Marucco, Gianluca

2017-01-29

Global Navigation Satellite Systems (GNSSs) remain the principal mean of positioning in many applications and systems, but in several types of environment, the performance of standalone receivers is degraded. Although many works show the benefits of the integration between GNSS and Inertial Navigation Systems (INSs), tightly-coupled architectures are mainly implemented in professional devices and are based on high-grade Inertial Measurement Units (IMUs). This paper investigates the performance improvements enabled by the tight integration, using low-cost sensors and a mass-market GNSS receiver. Performance is assessed through a series of tests carried out in real urban scenarios and is compared against commercial modules, operating in standalone mode or featuring loosely-coupled integrations. The paper describes the developed tight-integration algorithms with a terse mathematical model and assesses their efficacy from a practical perspective.

Collapse and coexistence for a molecular braid with an attractive interaction component subject to mechanical forces.

PubMed

Lee, Dominic J O'

2015-04-15

Dual mechanical braiding experiments provide a useful tool with which to investigate the nature of interactions between rod-like molecules, for instance actin and DNA. In conditions close to molecular condensation, one would expect an appearance of a local minimum in the interaction potential between the two molecules. We investigate this situation, introducing an attractive component into the interaction potential, using a model developed for describing such experiments. We consider both attractive interactions that do not depend on molecular structure and those which depend on a DNA-like helix structure. In braiding experiments, an attractive term may lead to certain effects. A local minimum may cause molecules to collapse from a loosely braided configuration into a tight one, occurring at a critical value of the moment applied about the axis of the braid. For a fixed number of braid pitches, this may lead to coexistence between the two braiding states, tight and loose. Coexistence implies certain proportions of the braid are in each state, their relative size depending on the number of braid pitches. This manifests itself as a linear dependence in numerically calculated quantities as functions of the number of braid pitches. Also, in the collapsed state, the braid radius stays roughly constant. Furthermore, if the attractive interaction is helix dependent, the left-right handed braid symmetry is broken. For a DNA like charge distribution, using the Kornyshev-Leikin interaction model, our results suggest that significant braid collapse and coexistence only occurs for left handed braids. Regardless of the interaction model, the study highlights the possible qualitative physics of braid collapse and coexistence; and the role helix specific forces might play, if important. The model could be used to connect other microscopic theories of interaction with braiding experiments.

Advanced variable speed air source integrated heat pump (AS-IHP) development - CRADA final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baxter, Van D.; Rice, C. Keith; Munk, Jeffrey D.

2015-09-30

Between August 2011 and September 2015, Oak Ridge National Laboratory (ORNL) and Nordyne, LLC (now Nortek Global HVAC LLC, NGHVAC) engaged in a Cooperative Research and Development Agreement (CRADA) to develop an air-source integrated heat pump (AS-IHP) system for the US residential market. Two generations of laboratory prototype systems were designed, fabricated, and lab-tested during 2011-2013. Performance maps for the system were developed using the latest research version of the DOE/ORNL Heat Pump Design Model, or HPDM, (Rice 1991; Rice and Jackson 2005; Shen et al 2012) as calibrated against the lab test data. These maps were the input tomore » the TRNSYS (SOLAR Energy Laboratory, et al, 2010) system to predict annual performance relative to a baseline suite of equipment meeting minimum efficiency standards in effect in 2006 (combination of 13 SEER air-source heat pump (ASHP) and resistance water heater with Energy Factor (EF) of 0.9). Predicted total annual energy savings, while providing space conditioning and water heating for a tight, well insulated 2600 ft2 (242 m2) house at 5 U.S. locations, ranged from 46 to 61%, averaging 52%, relative to the baseline system (lowest savings at the cold-climate Chicago location). Predicted energy use for water heating was reduced 62 to 76% relative to resistance WH. Based on these lab prototype test and analyses results a field test prototype was designed and fabricated by NGHVAC. The unit was installed in a 2400 ft2 (223 m2) research house in Knoxville, TN and field tested from May 2014 to April 2015. Based on the demonstrated field performance of the AS-IHP prototype and estimated performance of a baseline system operating under the same loads and weather conditions, it was estimated that the prototype would achieve ~40% energy savings relative to the minimum efficiency suite. The estimated WH savings were >60% and SC mode savings were >50%. But estimated SH savings were only about 20%. It is believed that had the test house been better insulated (more like the house used for the savings predictions noted above) and the IHP system nominal capacity been a bit lower that the energy savings estimate would have been closer to 45% or more (similar to the analytical prediction for the cold climate location of Chicago).« less

Configuration of separability and tests for multipartite entanglement in bell-type experiments.

PubMed

Nagata, Koji; Koashi, Masato; Imoto, Nobuyuki

2002-12-23

We derive tight quadratic inequalities for all kinds of hybrid separable-inseparable n-particle density operators on an arbitrary dimensional space. This methodology enables us to derive a tight quadratic inequality as tests for full n-partite entanglement in various Bell-type correlation experiments on the systems that may not be identified as a collection of qubits, e.g., those involving photons measured by incomplete detectors. It is also proved that when the two measured observables are assumed to precisely anticommute, a stronger quadratic inequality can be used as a witness of full n-partite entanglement.

Pulmonary Function Tests

MedlinePlus

... heavily for at least 30 minutes before the test. ■■ Do not wear tight clothing that makes it difficult for you ... be blowing into a tube connected to a machine (spirometer). To get the “best” test result, the test is repeated three times. You ...

Latitude and Power Characteristics of Solar Activity at the End of the Maunder Minimum

NASA Astrophysics Data System (ADS)

Ivanov, V. G.; Miletsky, E. V.

2017-12-01

Two important sources of information about sunspots in the Maunder minimum are the Spörer catalog (Spörer, 1889) and observations of the Paris observatory (Ribes and Nesme-Ribes, 1993), which cover in total the last quarter of the 17th and the first two decades of the 18th century. These data, in particular, contain information about sunspot latitudes. As we showed in (Ivanov et al., 2011; Ivanov and Miletsky, 2016), dispersions of sunspot latitude distributions are tightly related to sunspot indices, and we can estimate the level of solar activity in the past using a method which is not based on direct calculation of sunspots and weakly affected by loss of observational data. The latitude distributions of sunspots in the time of transition from the Maunder minimum to the regular regime of solar activity proved to be wide enough. It gives evidences in favor of, first, not very low cycle no.-3 (1712-1723) with the Wolf number in maximum W = 100 ± 50, and, second, nonzero activity in the maximum of cycle no.-4 (1700-1711) W = 60 ± 45. Therefore, the latitude distributions in the end of the Maunder minimum are in better agreement with the traditional Wolf numbers and new revisited indices of activity SN and GN (Clette et al., 2014; Svalgaard and Schatten, 2016) than with the GSN (Hoyt and Schatten, 1998); the latter provide much lower level of activity in this epoch.

Effect of Extracorporeal Shock Wave Therapy on Hamstring Tightness in Healthy Subjects: A Pilot Study

PubMed Central

Kim, Yong Wook; Chang, Won Hyuk; Kim, Na Young; Kwon, Jun Beom

2017-01-01

Purpose To assess the effect of extracorporeal shock wave therapy (ESWT) for healthy participants with hamstring tightness. Materials and Methods This study was performed at a university rehabilitation hospital. Twenty nine healthy adults with hamstring tightness were enrolled and randomly allocated into four groups (ESWT, stretching exercise, ESWT with stretching exercise, and control). The effects of individual treatments were compared by the finger-to-floor test and popliteal angle. Results The ESWT group, stretching exercise group and ESWT with stretching exercise group had decreased finger-to-floor distances and right popliteal angles immediately after intervention, compared with the control group (p<0.05). At 4 weeks after completion of the interventions, finger-to-floor distances and the right popliteal angle in only the ESWT with stretching exercise group showed a significant improvement, compared with the control group (p=0.008 and 0.023). Conclusion While ESWT and stretching both reduced hamstring tightness immediately after interventions, only ESWT with stretching exercise maintained the significantly improved relief of hamstring tightness significantly after 4 weeks. PMID:28332373

Application of a Physics-Based Stabilization Criterion to Flight System Thermal Testing

NASA Technical Reports Server (NTRS)

Baker, Charles; Garrison, Matthew; Cottingham, Christine; Peabody, Sharon

2010-01-01

The theory shown here can provide thermal stability criteria based on physics and a goal steady state error rather than on an arbitrary "X% Q/mC(sub P)" method. The ability to accurately predict steady-state temperatures well before thermal balance is reached could be very useful during testing. This holds true for systems where components are changing temperature at different rates, although it works better for the components closest to the sink. However, the application to these test cases shows some significant limitations: This theory quickly falls apart if the thermal control system in question is tightly coupled to a large mass not accounted for in the calculations, so it is more useful in subsystem-level testing than full orbiter tests. Tight couplings to a fluctuating sink causes noise in the steady state temperature predictions.

Obtaining spheroplasts of armored dinoflagellates and first single-channel recordings of their ion channels using patch-clamping.

PubMed

Pozdnyakov, Ilya; Matantseva, Olga; Negulyaev, Yuri; Skarlato, Sergei

2014-09-05

Ion channels are tightly involved in various aspects of cell physiology, including cell signaling, proliferation, motility, endo- and exo-cytosis. They may be involved in toxin production and release by marine dinoflagellates, as well as harmful algal bloom proliferation. So far, the patch-clamp technique, which is the most powerful method to study the activity of ion channels, has not been applied to dinoflagellate cells, due to their complex cellulose-containing cell coverings. In this paper, we describe a new approach to overcome this problem, based on the preparation of spheroplasts from armored bloom-forming dinoflagellate Prorocentrum minimum. We treated the cells of P. minimum with a cellulose synthesis inhibitor, 2,6-dichlorobenzonitrile (DCB), and found out that it could also induce ecdysis and arrest cell shape maintenance in these microalgae. Treatment with 100-250 µM DCB led to an acceptable 10% yield of P. minimum spheroplasts and was independent of the incubation time in the range of 1-5 days. We show that such spheroplasts are suitable for patch-clamping in the cell-attached mode and can form 1-10 GOhm patch contact with a glass micropipette, allowing recording of ion channel activity. The first single-channel recordings of dinoflagellate ion channels are presented.

Obtaining Spheroplasts of Armored Dinoflagellates and First Single-Channel Recordings of Their Ion Channels Using Patch-Clamping

PubMed Central

Pozdnyakov, Ilya; Matantseva, Olga; Negulyaev, Yuri; Skarlato, Sergei

2014-01-01

Ion channels are tightly involved in various aspects of cell physiology, including cell signaling, proliferation, motility, endo- and exo-cytosis. They may be involved in toxin production and release by marine dinoflagellates, as well as harmful algal bloom proliferation. So far, the patch-clamp technique, which is the most powerful method to study the activity of ion channels, has not been applied to dinoflagellate cells, due to their complex cellulose-containing cell coverings. In this paper, we describe a new approach to overcome this problem, based on the preparation of spheroplasts from armored bloom-forming dinoflagellate Prorocentrum minimum. We treated the cells of P. minimum with a cellulose synthesis inhibitor, 2,6-dichlorobenzonitrile (DCB), and found out that it could also induce ecdysis and arrest cell shape maintenance in these microalgae. Treatment with 100–250 µM DCB led to an acceptable 10% yield of P. minimum spheroplasts and was independent of the incubation time in the range of 1–5 days. We show that such spheroplasts are suitable for patch-clamping in the cell-attached mode and can form 1–10 GOhm patch contact with a glass micropipette, allowing recording of ion channel activity. The first single-channel recordings of dinoflagellate ion channels are presented. PMID:25199048

76 FR 50164 - Protocol Gas Verification Program and Minimum Competency Requirements for Air Emission Testing...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-12

...-AQ06 Protocol Gas Verification Program and Minimum Competency Requirements for Air Emission Testing... correct certain portions of the Protocol Gas Verification Program and Minimum Competency Requirements for... final rule that amends the Agency's Protocol Gas Verification Program (PGVP) and the minimum competency...

An Analysis of Minimum System Requirements to Support Computerized Adaptive Testing.

DTIC Science & Technology

1986-09-01

adaptive test ( CAT ); adaptive test ing A;4SRAC:’ (Continue on reverie of necessary and ident4f by block number) % This pape-r discusses the minimum system...requirements needed to develop a computerized adaptive test ( CAT ). It lists some of the benefits of adaptive testing, establishes a set of...discusses the minimum system requirements needed to develop a computerized adaptive test ( CAT ). It lists some of the benefits of adaptive testing

Film-based delivery quality assurance for robotic radiosurgery: Commissioning and validation.

PubMed

Blanck, Oliver; Masi, Laura; Damme, Marie-Christin; Hildebrandt, Guido; Dunst, Jürgen; Siebert, Frank-Andre; Poppinga, Daniela; Poppe, Björn

2015-07-01

Robotic radiosurgery demands comprehensive delivery quality assurance (DQA), but guidelines for commissioning of the DQA method is missing. We investigated the stability and sensitivity of our film-based DQA method with various test scenarios and routine patient plans. We also investigated the applicability of tight distance-to-agreement (DTA) Gamma-Index criteria. We used radiochromic films with multichannel film dosimetry and re-calibration and our analysis was performed in four steps: 1) Film-to-plan registration, 2) Standard Gamma-Index criteria evaluation (local-pixel-dose-difference ≤2%, distance-to-agreement ≤2 mm, pass-rate ≥90%), 3) Dose distribution shift until maximum pass-rate (Maxγ) was found (shift acceptance <1 mm), and 4) Final evaluation with tight DTA criteria (≤1 mm). Test scenarios consisted of purposefully introduced phantom misalignments, dose miscalibrations, and undelivered MU. Initial method evaluation was done on 30 clinical plans. Our method showed similar sensitivity compared to the standard End-2-End-Test and incorporated an estimate of global system offsets in the analysis. The simulated errors (phantom shifts, global robot misalignment, undelivered MU) were detected by our method while standard Gamma-Index criteria often did not reveal these deviations. Dose miscalibration was not detected by film alone, hence simultaneous ion-chamber measurement for film calibration is strongly recommended. 83% of the clinical patient plans were within our tight DTA tolerances. Our presented methods provide additional measurements and quality references for film-based DQA enabling more sensitive error detection. We provided various test scenarios for commissioning of robotic radiosurgery DQA and demonstrated the necessity to use tight DTA criteria. Copyright © 2015 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

Search for Intra-day Optical Variability in Mrk 501

NASA Astrophysics Data System (ADS)

Feng, Hai-Cheng; Liu, H. T.; Fan, X. L.; Zhao, Yinghe; Bai, J. M.; Wang, Fang; Xiong, D. R.; Li, S. K.

2017-11-01

We present our observations of the optical intra-day variability (IDV) in γ-ray BL Lac object Mrk 501. The observations were run with the 1.02 m and 2.4 m optical telescopes at Yunnan Observatories from 2005 April to 2012 May. The light curve at the R band on 2010 May 15 passes both variability tests (the F-test and the ANOVA test). A flare within the light curve on 2010 May 15 has a magnitude change of {{Δ }}m=0.03+/- {0.005}{stat}+/- {0.007}{sys} mag, a darkening timescale of {τ }{{d}}=26.7 minutes, and an amplitude of IDV {Amp}=2.9 % +/- 0.7 % . A decline described by 11 consecutive flux measurements within the flare can be fitted linearly with a Pearson’s correlation coefficient r = 0.945 at the confidence level of > 99.99 % . Under the assumptions that the IDV is tightly connected to the mass of the black hole, and that the flare duration, being two times {τ }{{d}}, is representative of the minimum characteristic timescale, we can derive upper bounds to the mass of the black hole. In the case of the Kerr black hole, the timescale of {{Δ }}{t}\\min {ob}=0.89 hr gives {M}\\bullet ≲ {10}9.20{M}⊙ , which is consistent with measurements reported in the literature. This agreement indicates that the hypothesis about {M}\\bullet and {{Δ }}{t}\\min {ob} is consistent with the measurements/data.

Examinations for leak tightness of actively cooled components in ITER and fusion devices

NASA Astrophysics Data System (ADS)

Hirai, T.; Barabash, V.; Carrat, R.; Chappuis, Ph; Durocher, A.; Escourbiac, F.; Merola, M.; Raffray, R.; Worth, L.; Boscary, J.; Chantant, M.; Chuilon, B.; Guilhem, D.; Hatchressian, J.-C.; Hong, S. H.; Kim, K. M.; Masuzaki, S.; Mogaki, K.; Nicolai, D.; Wilson, D.; Yao, D.

2017-12-01

Any leak in one of the ITER actively cooled components would cause significant consequences for machine operations; therefore, the risk of leak must be minimized as much as possible. In this paper, the strategy of examination to ensure leak tightness of the ITER internal components (i.e. examination of base materials, vacuum boundary joints and final components) and the hydraulic parameters for ITER internal components are summarized. The experiences of component tests, especially hot helium leak tests in recent fusion devices, were reviewed and the parameters were discussed. Through these experiences, it was confirmed that the hot He leak test was effective to detect small leak paths which were not always possible to detect by volumetric examination due to limited spatial resolution.

Comparative study on the treatment of Rockwood type III acute acromioclavicular dislocation: Clinical results from the TightRope® technique vs. K-wire fixation.

PubMed

Horst, K; Garving, C; Thometzki, T; Lichte, P; Knobe, M; Dienstknecht, T; Hofman, M; Pape, H-C

2017-04-01

The aim of this study was to address the inconsistency regarding the operative treatment of Rockwood type III acromioclavicular joint separation. We compared results after single- and double TightRope ® reduction with results after acromioclavicular transfixation via K-wires only and additional ligament augmentation in acute acromioclavicular (AC) joint separations graded Rockwood type III, and hypothesized that the TightRope ® technique leads to better clinical and radiological results. We conducted a retrospective clinical cohort study and included 42 consecutive patients (mean age 43 years [24-66]) diagnosed and operatively treated between 2004 and 2012 (mean follow-up was 54.6 months [15-118]). Specific shoulder scores as well as scores reflecting the patients' overall mental and physical health status were used. Radiological evaluation was also performed. The SF12 test revealed comparability between all subgroups. Specific shoulder tests and a visual analogue scale demonstrated comparable results. Radiographic measurements showed a significant reduction in the AC distance and CC distance after surgery in all subgroups. The early complication rate was 9.5% for all patients, while late complications occurred in 14.3% of all cases. Compared to the established methods, the operative TightRope ® procedures represent a safe alternative in Rockwood III injuries. All investigated techniques predominantly led to good and excellent clinical results in acute Rockwood type III AC joint instabilities. Avoidance of material removal and shorter hospital stays appear to speak in favour for the TightRope ® technique. IV. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

42 CFR 84.207 - Bench tests; gas and vapor tests; minimum requirements; general.

Code of Federal Regulations, 2013 CFR

2013-10-01

....) Flowrate (l.p.m.) Number of tests Penetration 1 (p.p.m.) Minimum life 2 (min.) Ammonia As received NH3 1000... minimum life shall be one-half that shown for each type of gas or vapor. Where a respirator is designed... at predetermined concentrations and rates of flow, and that has means for determining the test life...

42 CFR 84.207 - Bench tests; gas and vapor tests; minimum requirements; general.

Code of Federal Regulations, 2014 CFR

2014-10-01

....) Flowrate (l.p.m.) Number of tests Penetration 1 (p.p.m.) Minimum life 2 (min.) Ammonia As received NH3 1000... minimum life shall be one-half that shown for each type of gas or vapor. Where a respirator is designed... at predetermined concentrations and rates of flow, and that has means for determining the test life...

42 CFR 84.207 - Bench tests; gas and vapor tests; minimum requirements; general.

Code of Federal Regulations, 2012 CFR

2012-10-01

....) Flowrate (l.p.m.) Number of tests Penetration 1 (p.p.m.) Minimum life 2 (min.) Ammonia As received NH3 1000... minimum life shall be one-half that shown for each type of gas or vapor. Where a respirator is designed... at predetermined concentrations and rates of flow, and that has means for determining the test life...

Aging Behavior of the EPDM O-Rings in the H1616 Shipping Package

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daugherty, W.; Stefek, T.; Skidmore, E.

The H1616 shipping package is used within the DOE complex for shipping tritium reservoirs. The annual recertification frequency can create logistical difficulties with other constraints on the timing of shipments; thus, a longer re-certification period is desirable. The ethylene propylene diene monomer (EPDM) O-rings used in the H1616 shipping package are being aged and tested at the Savannah River National Laboratory (SRNL) to provide a technical basis for extending the annual maintenance of the H1616 shipping package. H1616 EPDM O-rings are being aged at elevated temperature, and tested for degradation in mechanical properties, compression stress relaxation (CSR) behavior, and leakmore » performance. Mechanical properties of aged O-rings show significant degradation can occur, but an inert atmosphere (argon backfill) greatly reduces the rate of degradation. The CSR behavior of O-rings was evaluated in air at 79 to 177 °C. These collective data were used to develop a predictive model for extrapolation of CSR behavior to relevant service temperatures (<67 °C). O-rings were also aged in H1616 Containment Vessels (CV) in an inert atmosphere at 71 to 149 °C. The vessels are helium leak tested periodically to determine if they continue to remain leak-tight. The vessel tests provide a solid demonstration that the H1616 O-rings will remain leak-tight at temperatures up to 113 °C for up to approximately 2.3 years. Significantly longer periods of leak-tight service are expected at the lower temperatures actually experienced in service. The predictive model developed from the CSR data conservatively indicates a service life of ~5 years at 67 °C. Although the relationship between CSR behavior and leak-tight performance has not been established for this design, the CSR predictions for this O-ring are conservative relative to leak-tight performance. Based on the collective data developed to date, SRNL has recommended that the maintenance interval for the H1616 package be extended from 1 year to 2 years. Future recommendations in support of even longer maintenance intervals are expected, as additional aging data become available.« less

24 CFR 3280.406 - Air chamber test method for certification and qualification of formaldehyde emission levels.

Code of Federal Regulations, 2010 CFR

2010-04-01

... particleboard is produced or surface-finished, whichever is later, the panels must be dead-stacked or air-tight... with the Standard Test Method for Determining Formaldehyde Levels from Wood Products Under Defined Test...

42 CFR 84.157 - Airflow resistance test; Type C supplied-air respirator, pressure-demand class; minimum...

Code of Federal Regulations, 2012 CFR

2012-10-01

... test; Type C supplied-air respirator, pressure-demand class; minimum requirements. (a) The static... 42 Public Health 1 2012-10-01 2012-10-01 false Airflow resistance test; Type C supplied-air respirator, pressure-demand class; minimum requirements. 84.157 Section 84.157 Public Health PUBLIC HEALTH...

42 CFR 84.157 - Airflow resistance test; Type C supplied-air respirator, pressure-demand class; minimum...

Code of Federal Regulations, 2013 CFR

2013-10-01

... test; Type C supplied-air respirator, pressure-demand class; minimum requirements. (a) The static... 42 Public Health 1 2013-10-01 2013-10-01 false Airflow resistance test; Type C supplied-air respirator, pressure-demand class; minimum requirements. 84.157 Section 84.157 Public Health PUBLIC HEALTH...

42 CFR 84.157 - Airflow resistance test; Type C supplied-air respirator, pressure-demand class; minimum...

Code of Federal Regulations, 2014 CFR

2014-10-01

... test; Type C supplied-air respirator, pressure-demand class; minimum requirements. (a) The static... 42 Public Health 1 2014-10-01 2014-10-01 false Airflow resistance test; Type C supplied-air respirator, pressure-demand class; minimum requirements. 84.157 Section 84.157 Public Health PUBLIC HEALTH...

Numerical Optimization of Density Functional Tight Binding Models: Application to Molecules Containing Carbon, Hydrogen, Nitrogen, and Oxygen

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krishnapriyan, A.; Yang, P.; Niklasson, A. M. N.

New parametrizations for semiempirical density functional tight binding (DFTB) theory have been developed by the numerical optimization of adjustable parameters to minimize errors in the atomization energy and interatomic forces with respect to ab initio calculated data. Initial guesses for the radial dependences of the Slater- Koster bond integrals and overlap integrals were obtained from minimum basis density functional theory calculations. The radial dependences of the pair potentials and the bond and overlap integrals were represented by simple analytic functions. The adjustable parameters in these functions were optimized by simulated annealing and steepest descent algorithms to minimize the value ofmore » an objective function that quantifies the error between the DFTB model and ab initio calculated data. The accuracy and transferability of the resulting DFTB models for the C, H, N, and O system were assessed by comparing the predicted atomization energies and equilibrium molecular geometries of small molecules that were not included in the training data from DFTB to ab initio data. The DFTB models provide accurate predictions of the properties of hydrocarbons and more complex molecules containing C, H, N, and O.« less

Effect of impurity doping on tunneling conductance in AB-stacked bi-layer graphene: A tight-binding study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rout, G. C., E-mail: siva1987@iopb.res.in, E-mail: skp@iopb.res.in, E-mail: gcr@iopb.res.in; Sahu, Sivabrata; Panda, S. K.

2016-04-13

We report here a microscopic tight-binding model calculation for AB-stacked bilayer graphene in presence of biasing potential between the two layers and the impurity effects to study the evolution of the total density of states with special emphasis on opening of band gap near Dirac point. We have calculated the electron Green’s functions for both the A and B sub-lattices by Zubarev technique. The imaginary part of the Green’s function gives the partial and total density of states of electrons. The density of states are computed numerically for 1000 × 1000 grid points of the electron momentum. The evolution ofmore » the opening of band gap near van-Hove singularities as well as near Dirac point is investigated by varying the different interlayer hoppings and the biasing potentials. The inter layer hopping splits the density of states at van-Hove singularities and produces a V-shaped gap near Dirac point. Further the biasing potential introduces a U shaped gap near Dirac point with a density minimum at the applied potential(i.e. at V/2).« less

Numerical Optimization of Density Functional Tight Binding Models: Application to Molecules Containing Carbon, Hydrogen, Nitrogen, and Oxygen

DOE PAGES

Krishnapriyan, A.; Yang, P.; Niklasson, A. M. N.; ...

2017-10-17

New parametrizations for semiempirical density functional tight binding (DFTB) theory have been developed by the numerical optimization of adjustable parameters to minimize errors in the atomization energy and interatomic forces with respect to ab initio calculated data. Initial guesses for the radial dependences of the Slater- Koster bond integrals and overlap integrals were obtained from minimum basis density functional theory calculations. The radial dependences of the pair potentials and the bond and overlap integrals were represented by simple analytic functions. The adjustable parameters in these functions were optimized by simulated annealing and steepest descent algorithms to minimize the value ofmore » an objective function that quantifies the error between the DFTB model and ab initio calculated data. The accuracy and transferability of the resulting DFTB models for the C, H, N, and O system were assessed by comparing the predicted atomization energies and equilibrium molecular geometries of small molecules that were not included in the training data from DFTB to ab initio data. The DFTB models provide accurate predictions of the properties of hydrocarbons and more complex molecules containing C, H, N, and O.« less

Indoor-outdoor relationships of PM2.5 in four residential dwellings in winter in the Yangtze River Delta, China.

PubMed

Wang, Fang; Meng, Dan; Li, Xiuwei; Tan, Junjie

2016-08-01

Indoor and outdoor air PM2.5 concentrations in four residential dwellings characterized with different building envelope air tightness levels and HVAC-filter configurations in Yangtze River Delta (YRD) were measured during winter periods in 2014-2015. Steady-state models for indoor PM2.5 were developed for each of the tested dwellings, based on mass balance equation. The indoor air PM2.5 concentrations in the four tested apartments were significantly different. The lowest geometric mean values of indoor air PM2.5 concentrations, I/O ratios, and infiltration factor were observed in D3 with high air tightness and without HVAC-filter system (26.0 μg/m(3), 0.197, and 0.167, respectively), while the highest geometric mean values of indoor air PM2.5 concentrations, I/O ratios, and infiltration factor were observed in D1 (64.9 μg/m(3), 0.876, and 0.867, respectively). For apartment D1 with normal air tightness and without any HVAC-filter system, indoor air PM2.5 concentrations were significantly correlated with outdoor PM2.5 concentrations, especially in severe ambient pollution days, when closed windows can only play a very weak role on the decline of indoor PM2.5 concentrations. With the enhancement of building air tightness, the indoor air PM2.5 concentrations can be decreased effectively and don't vary as much in response to fluctuations in ambient concentrations. For buildings with normal air tightness, the use of HVAC-filter combinations will decrease the indoor PM2.5 significantly. However, for buildings with enhanced air tightness, the only use of fresh makeup air supply system with filter may increase the indoor PM2.5 concentrations. The improvement of filter efficiency for both fresh makeup air and indoor recirculated air are very important. However, purifiers for indoor recirculated air were highly recommended for all buildings. Copyright © 2016 Elsevier Ltd. All rights reserved.

Competitive adsorption behaviors of carbon dioxide and n-dodecane mixtures in 13X molecular sieve

NASA Astrophysics Data System (ADS)

Zhu, Chaofan; Dong, Mingzhe; Gong, Houjian

2018-01-01

The CO2 cyclic injection has been proven to be effective to enhance tight oil recovery under constant reservoir temperature and down hole pressure conditions. However, the enhance tight oil recovery mechanism was unclear, especially the adsorption of the CO2 and alkane in the surface. Therefore, it is great important to study the adsorption mechanism of CO2 and alkane mixtures in tight oil. In this study, a new experimental method and apparatus have been designed to test the change of the mole fraction of CO2 and n-C12 before and after the adsorption equilibrium. Then, the adsorption amount of CO2 and n-C12 was obtained by a mathematical method. Moreover, the adsorption character of CO2 and n-C12 mixtures in 13X molecular sieve and the effect of pressure on the adsorption and amount were studied. The results show that the adsorption of CO2 and the desorption of n-C12 follow the Langmuir adsorption. This study provides a straightforward method to experimentally determine the adsorption properties of the tight oil, which can be used to evaluate enhanced tight oil recovery by CO2 injection.

A Project to Design and Build the Magnets for a New Test Beamline, the ATF2, at KEK

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spencer, Cherrill M.; /slac; Sugahara, Ryuhei

2011-02-07

In order to achieve the high luminosity required at the proposed International Linear Collider (ILC), it is critical to focus the beams to nanometer size with the ILC Beam Delivery System, and to maintain the beams collisions with a nanometer-scale stability. To establish the technologies associated with this ultra-high precision beam handling, a special beamline has been designed and built as an extension of the existing extraction beamline of the Accelerator Test Facility at KEK, Japan. The ATF provides an adequate ultra-low emittance electron beam that is comparable to the ILC requirements; the ATF2 mimics the ILC final focus systemmore » to create a tightly focused, stable beam. There are 37 magnets in the ATF2, 29 quadrupoles, 5 sextupoles and 3 bends. These magnets had to be acquired in a short time and at minimum cost, which led to various acquisition strategies; but nevertheless they had to meet strict requirements on integrated strength, physical dimensions, compatibility with existing magnet movers and beam position monitors, mechanical stability and field stability and quality. This paper will describe how 2 styles of quadrupoles, 2 styles of sextupoles, one dipole style and their supports were designed, fabricated, refurbished or modified, measured and aligned by a small team of engineers from 3 continents.« less

Terrestrial tight oil reservoir characteristics and Graded Resource Assessment in China

NASA Astrophysics Data System (ADS)

Wang, Shejiao; Wu, Xiaozhi; Guo, Giulin

2016-04-01

The success of shale/tight plays and the advanced exploitation technology applied in North America have triggered interest in exploring and exploiting tight oil in China. Due to the increased support of exploration and exploitation，great progress has been made in Erdos basin, Songliao basin, Junggar basin, Santanghu basin, Bohai Bay basin, Qaidam Basin, and Sichuan basin currently. China's first tight oil field has been found in Erdos basin in 2015, called xinanbian oil field, with over one hundred million tons oil reserves and one million tons of production scale. Several hundred million tons of tight oil reserve has been found in other basins, showing a great potential in China. Tight oil in China mainly developed in terrestrial sedimentary environment. According to the relations of source rock and reservoir, the source-reservoir combination of tight oil can be divided into three types, which are bottom generating and top storing tight oil,self- generating and self-storing tight oil，top generating and bottom storing tight oil. The self- generating and self-storing tight oil is the main type discovered at present. This type of tight oil has following characteristics:(1) The formation and distribution of tight oil are controlled by high quality source rocks. Terrestrial tight oil source rocks in China are mainly formed in the deep to half deep lacustrine facies. The lithology includes dark mudstone, shale, argillaceous limestone and dolomite. These source rocks with thickness between 20m-150m, kerogen type mostly I-II, and peak oil generation thermal maturity(Ro 0.6-1.4%), have great hydrocarbon generating potential. Most discovered tight oil is distributed in the area of TOC greater than 2 %.( 2) the reservoir with strong heterogeneity is very tight. In these low porosity and permeability reservoir,the resources distribution is controlled by the physical property. Tight sandstone, carbonate and hybrid sedimentary rocks are three main tight reservoir types in China. The porosity is 2-14%(average 5-10%)and the permeability is less than 1mD. The laboratory test and exploration practice confirmed that the oil content was positively related to physical property. The higher the porosity, the better the oil content will have. (3) Source rock and reservoir are superimposed. From the contact relationship of source rock and reservoir, the reservoir developed in the source rock has the advantage of capturing oil and gas, so the oil saturation can be as high as 70-80%. (4) The increased pressure caused by hydrocarbon generation and the connected fracture are the key factors for tight oil accumulation. The Fuyu tight oil formed underling source rock in Songliao Basin is a good example. The fracture system is the key factor for tight oil accumulation. Considering the strong heterogeneity of terrestrial tight oil reservoir in china, we create hierarchical resource abundance analogy, EUR analogy, cell element volumetric methods to evaluate tight oil resource potential. In order to find exploration "sweet spots", establishing tight oil resource classification evaluation standards are key steps to objectively evaluate tight oil resource distribution. The resource classification evaluation standards are established by the relationship analysis between reservoir properties and oil properties, and the correlation analysis between production, resource abundance, and reservoir thickness. The first-grade tight oil resource, which is recently available and can easily be developed, has following main parameters: the porosity is greater than 8%, thickness is over 10m, resource abundance is above 150,000 tons / km2, and pressure coefficient is greater than 1.3; The second-grade tight oil resource is currently unavailable, but with advanced technology can expected to be developed. The main parameters are as following: the porosity is 5% -8%, thickness is less than 5-10m, resource abundance is 50000-150000 tons / km2, the pressure coefficient is 1.0 to 1.3; The third-grade resource has poor quality, need long-term to be effective explored, has following main parameters: porosity is less than 5%, the thickness is less than 5m, resource abundance is less than 50,000 tons / km2, the pressure coefficient is less than 1.0. Using created resource evaluation methods, the tight oil resources has been calculated in china. The first-grade recoverable resource of tight oil is about 610 million tons. The second-grade recoverable resource is 450 million tons. And the third-grade recoverable resource is 400 million tons. The first-grade and second-grade recoverable resources are mainly distributed in the Ordos basin, Bohai Bay basin, Songliao basin, Junggar basin, and Qaidam Basin. The third-grade resources are mainly distributed in Sichuan and Santanghu basin.

The X3LYP extended density functional accurately describes H-bonding but fails completely for stacking.

PubMed

Cerný, Jirí; Hobza, Pavel

2005-04-21

The performance of the recently introduced X3LYP density functional which was claimed to significantly improve the accuracy for H-bonded and van der Waals complexes was tested for extended H-bonded and stacked complexes (nucleic acid base pairs and amino acid pairs). In the case of planar H-bonded complexes (guanine...cytosine, adenine...thymine) the DFT results nicely agree with accurate correlated ab initio results. For the stacked pairs (uracil dimer, cytosine dimer, adenine...thymine and guanine...cytosine) the DFT fails completely and it was even not able to localize any minimum at the stacked subspace of the potential energy surface. The geometry optimization of all these stacked clusters leads systematically to the planar H-bonded pairs. The amino acid pairs were investigated in the crystal geometry. DFT again strongly underestimates the accurate correlated ab initio stabilization energies and usually it was not able to describe the stabilization of a pair. The X3LYP functional thus behaves similarly to other current functionals. Stacking of nucleic acid bases as well as interaction of amino acids was described satisfactorily by using the tight-binding DFT method, which explicitly covers the London dispersion energy.

Deficiency mapping of quantitative trait loci affecting longevity in Drosophila melanogaster.

PubMed Central

Pasyukova, E G; Vieira, C; Mackay, T F

2000-01-01

In a previous study, sex-specific quantitative trait loci (QTL) affecting adult longevity were mapped by linkage to polymorphic roo transposable element markers, in a population of recombinant inbred lines derived from the Oregon and 2b strains of Drosophila melanogaster. Two life span QTL were each located on chromosomes 2 and 3, within sections 33E-46C and 65D-85F on the cytological map, respectively. We used quantitative deficiency complementation mapping to further resolve the locations of life span QTL within these regions. The Oregon and 2b strains were each crossed to 47 deficiencies spanning cytological regions 32F-44E and 64C-76B, and quantitative failure of the QTL alleles to complement the deficiencies was assessed. We initially detected a minimum of five and four QTL in the chromosome 2 and 3 regions, respectively, illustrating that multiple linked factors contribute to each QTL detected by recombination mapping. The QTL locations inferred from deficiency mapping did not generally correspond to those of candidate genes affecting oxidative and thermal stress or glucose metabolism. The chromosome 2 QTL in the 35B-E region was further resolved to a minimum of three tightly linked QTL, containing six genetically defined loci, 24 genes, and predicted genes that are positional candidates corresponding to life span QTL. This region was also associated with quantitative variation in life span in a sample of 10 genotypes collected from nature. Quantitative deficiency complementation is an efficient method for fine-scale QTL mapping in Drosophila and can be further improved by controlling the background genotype of the strains to be tested. PMID:11063689

16 CFR Table 3 to Part 1512 - Minimum Acceptable Values for the Quantity A Defined in the Retroreflective Tire and Rim Test...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Minimum Acceptable Values for the Quantity A Defined in the Retroreflective Tire and Rim Test Procedure 3 Table 3 to Part 1512 Commercial Practices... Retroreflective Tire and Rim Test Procedure Observation angle (degrees) Entrance angle (degrees) Minimum...

Influence of methyl functional groups on the stability of cubane carbon cage

NASA Astrophysics Data System (ADS)

Katin, Konstantin P.; Prudkovskiy, Vladimir S.; Maslov, Mikhail M.

2016-07-01

We present a quantum-chemical study to elucidate the structure, energetics and stability of isolated polymethylcubane molecules C8H8-q(CH3)q. The results obtained by means of originally developed nonorthogonal tight-binding approach are in good agreement with the existed experimental data for solid octamethylcubane C8(CH3)8. The isomerization mechanisms for polymethylcubane family are studied in detail and the minimum energy barriers' heights preventing the decomposition are calculated. The temperature dependence of octamethylcubane molecule lifetime to the decomposition moment was determined by direct molecular dynamics simulation. It is shown that methyl groups destabilize the cubic carbon cage, but less than nitro groups.

Internal V-Band Clamp

DOEpatents

Vaughn, Mark R.; Hafenrichter, Everett S.; Chapa, Agapito C.; Harris, Steven M.; Martinez, Marcus J.; Baty, Roy S.

2006-02-28

A system for clamping two tubular members together in an end-to-end relationship uses a split ring with a V-shaped outer rim that can engage a clamping surface on each member. The split ring has a relaxed closed state where the ends of the ring are adjacent and the outside diameter of the split ring is less than the minimum inside diameter of the members at their ends. The members are clamped when the split ring is spread into an elastically stretched position where the ring rim is pressed tightly against the interior surfaces of the members. Mechanisms are provided for removing the spreader so the split ring will return to the relaxed state, releasing the clamped members.

Optical properties of InAs/GaAs quantum dot superlattice structures

NASA Astrophysics Data System (ADS)

Imran, Ali; Jiang, Jianliang; Eric, Deborah; Zahid, M. Noaman; Yousaf, M.; Shah, Z. H.

2018-06-01

Quantum dot (QD) structure has potential applications in modern highly efficient optoelectronic devices due to their band-tuning. The device dimensions have been miniatured with increased efficiencies by virtue of this discovery. In this research, we have presented modified analytical and simulation results of InAs/GaAs QD superlattice (QDSL). We have applied tight binding model for the investigation of ground state energies using timeindependent Schrödinger equation (SE) with effective mass approximation. It has been investigated that the electron energies are confined due to wave function delocalization in closely coupled QD structures. The minimum ground state energy can be obtained by increasing the periodicity and decreasing the barrier layer thickness. We have calculated electronics and optical properties which includes ground state energies, transition energies, density of states (DOS), absorption coefficient and refractive index, which can be tuned by structure modification. In our results, the minimum ground state energy of QDSL is achieved to be 0.25 eV with a maximum period of 10 QDs. The minimum band to band and band to continuum transition energies are 63 meV and 130 meV with 2 nm barrier layer thickness respectively. The absorption coefficient of our proposed QDSL model is found to be maximum 1.2 × 104 cm-1 and can be used for highly sensitive infrared detector and high efficiency solar cells.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Warpinski, N.R.; Branagan, P.T.; Sattler, A.R.

This paper is a case study of the stimulation and testing of tight, lenticular sands in the paludal interval of the Mesaverde group in the Piceance basin at DOE's Multiwell Experiment (MWX) site in Colorado. Topics discussed include geologic data, stress test results, well testing, laboratory core studies, stimulation and stimulation analyses, and postfracture operations.

42 CFR 84.125 - Particulate tests; canisters containing particulate filters; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... filters; minimum requirements. 84.125 Section 84.125 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF... RESPIRATORY PROTECTIVE DEVICES Gas Masks § 84.125 Particulate tests; canisters containing particulate filters; minimum requirements. Gas mask canisters containing filters for protection against particulates (e.g...

42 CFR 84.125 - Particulate tests; canisters containing particulate filters; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... filters; minimum requirements. 84.125 Section 84.125 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF... RESPIRATORY PROTECTIVE DEVICES Gas Masks § 84.125 Particulate tests; canisters containing particulate filters; minimum requirements. Gas mask canisters containing filters for protection against particulates (e.g...

42 CFR 84.125 - Particulate tests; canisters containing particulate filters; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... filters; minimum requirements. 84.125 Section 84.125 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF... RESPIRATORY PROTECTIVE DEVICES Gas Masks § 84.125 Particulate tests; canisters containing particulate filters; minimum requirements. Gas mask canisters containing filters for protection against particulates (e.g...

42 CFR 84.125 - Particulate tests; canisters containing particulate filters; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... filters; minimum requirements. 84.125 Section 84.125 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF... RESPIRATORY PROTECTIVE DEVICES Gas Masks § 84.125 Particulate tests; canisters containing particulate filters; minimum requirements. Gas mask canisters containing filters for protection against particulates (e.g...

42 CFR 84.125 - Particulate tests; canisters containing particulate filters; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... filters; minimum requirements. 84.125 Section 84.125 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF... RESPIRATORY PROTECTIVE DEVICES Gas Masks § 84.125 Particulate tests; canisters containing particulate filters; minimum requirements. Gas mask canisters containing filters for protection against particulates (e.g...

49 CFR 572.200 - Instrumentation and test conditions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... a minimum mass moment of inertia of 3646 kg-cm2. (b) The test probe for the lateral abdomen impact... and it has a minimum mass moment of inertia of 3646 kg-cm2. (c) The test probe for the pelvis-iliac... impact surface 50.8 × 88.9 mm for a depth of at least 76 mm and a minimum mass moment of inertia of 5000...

49 CFR 572.200 - Instrumentation and test conditions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... a minimum mass moment of inertia of 3646 kg-cm2. (b) The test probe for the lateral abdomen impact... and it has a minimum mass moment of inertia of 3646 kg-cm2. (c) The test probe for the pelvis-iliac... impact surface 50.8 × 88.9 mm for a depth of at least 76 mm and a minimum mass moment of inertia of 5000...

Two-Finger Tightness: What Is It? Measuring Torque and Reproducibility in a Simulated Model.

PubMed

Acker, William B; Tai, Bruce L; Belmont, Barry; Shih, Albert J; Irwin, Todd A; Holmes, James R

2016-05-01

Residents in training are often directed to insert screws using "two-finger tightness" to impart adequate torque but minimize the chance of a screw stripping in bone. This study seeks to quantify and describe two-finger tightness and to assess the variability of its application by residents in training. Cortical bone was simulated using a polyurethane foam block (30-pcf density) that was prepared with predrilled holes for tightening 3.5 × 14-mm long cortical screws and mounted to a custom-built apparatus on a load cell to capture torque data. Thirty-three residents in training, ranging from the first through fifth years of residency, along with 8 staff members, were directed to tighten 6 screws to two-finger tightness in the test block, and peak torque values were recorded. The participants were blinded to their torque values. Stripping torque (2.73 ± 0.56 N·m) was determined from 36 trials and served as a threshold for failed screw placement. The average torques varied substantially with regard to absolute torque values, thus poorly defining two-finger tightness. Junior residents less consistently reproduced torque compared with other groups (0.29 and 0.32, respectively). These data quantify absolute values of two-finger tightness but demonstrate considerable variability in absolute torque values, percentage of stripping torque, and ability to consistently reproduce given torque levels. Increased years in training are weakly correlated with reproducibility, but experience does not seem to affect absolute torque levels. These results question the usefulness of two-finger tightness as a teaching tool and highlight the need for improvement in resident motor skill training and development within a teaching curriculum. Torque measuring devices may be a useful simulation tools for this purpose.

Tight-binding study of Si2Cn (n = 3 to 42) fullerene-like or nanodiamonds microclusters: are Si atoms isolated or adjacent?

NASA Astrophysics Data System (ADS)

Leleyter, M.; Olivi-Tran, N.

2008-12-01

We studied in tight-binding approximation involving spν hybridization (ν=2,3), some Si2Cn (n=3 to 42) microclusters. We then investigated, on one hand, fragments of fullerene-like structures (sp2), and on the other hand, nanodiamonds (sp3) of adamantane-type or a 44-atom nanodiamond (with 2 inner atoms which are assumed to play the role of bulk atoms). We compared the stabilities, i.e. the electronic energies of these clusters, according to the various positions of the 2 Si atoms. Results are very different in the two kinds of hybridization. Besides, they can be analysed according to two different points of view: either the clusters are considered as small particles with limited sizes, or they are assumed to be used as models in order to simulate the Si-atom behaviour in very larger systems. In sp2 hybridization (fullerene-like geometries), the most stable isomer is always encountered when the 2 Si atoms build a Si2 group, and this result holds for both viewpoints quoted above. Conversely, in sp3 hybridization (nanodiamonds), since Si atoms “prefer” sites having the minimum connectivity, they are never found in adjacent sites. We see that with a simple and fast computational method we can explain an experimental fact which is very interesting such as the relative position of two heteroatoms in the cluster. This enhances the generality and the fecondity in the tight binding approximation due essentially to the link between this model and the graph theory, link based on the topology of the clusters.

Development of a head impact monitoring "Intelligent Mouthguard".

PubMed

Hedin, Daniel S; Gibson, Paul L; Bartsch, Adam J; Samorezov, Sergey

2016-08-01

The authors present the development and laboratory system-level testing of an impact monitoring "Intelligent Mouthguard" intended to help with identification of potentially concussive head impacts and cumulative head impact dosage. The goal of Intelligent Mouthguard is to provide an indicator of potential concussion risk, and help caregiver identify athletes needing sideline concussion protocol testing. Intelligent Mouthguard may also help identify individuals who are at higher risk based on historical dosage. Intelligent Mouthguard integrates inertial sensors to provide 3-degree of freedom linear and rotational kinematics. The electronics are fully integrated into a custom mouthguard that couples tightly to the upper teeth. The combination of tight coupling and highly accurate sensor data means the Intelligent Mouthguard meets the National Football League (NFL) Level I validity specification based on laboratory system-level test data presented in this study.

Implications for Minority Groups of the Movement Toward Minimum-Competency Testing. A Symposium presented at the 1979 Annual Meeting of the National Council on Measurement in Education.

ERIC Educational Resources Information Center

ERIC Clearinghouse on Tests, Measurement, and Evaluation, Princeton, NJ.

Proceedings of the symposium on Implications for Minority Groups of the Movement Toward Minimum-Competency Testing (MCT) include the following papers: (1) "Implications of Minimum-Competency Testing for Minority Students" by A. Graham Down, who asserts that MCT offers more hope than any development in public school policy since 1954 for realizing…

Planet formation in binary systems: simulating coagulation using analytically determined collision velocities.

NASA Astrophysics Data System (ADS)

Silsbee, Kedron; Rafikov, Roman

2017-06-01

The existence of planets in tight binary systems presents an interesting puzzle. It is thought that cores of giant planets form via agglomeration of planetesimals in mutual collisions. However, in tight binary systems, one would naïvely expect the collision velocities between planetesimals to be so high that even 100 km bodies would be destroyed, rather than growing in mutual collisions. In these systems, planetesimals are perturbed by gravity from the companion star, and gravity and gas drag from a massive eccentric gas disk. There is a damaging secular resonance that occurs due to the combination of disk gravity and gravity from the binary companion, however the disk gravity can also create locations of low relative eccentricity between planetesimals of different sizes that would not exist if the disk gravity were ignored. Because the gas drag acts more strongly on smaller planetesimals, orbital eccentricity and apsidal angle depend on planetesimal size. Consequently, planetesimal collision velocities depend on the sizes of the collision partners. Same-size bodies collide at low velocity because their orbits are apsidally aligned. Therefore, often in a given environment some collisions will lead to planetesimal growth, and some to erosion or destruction. This variety of collisional outcomes makes it difficult to determine whether any planetesimals can grow to large sizes. We run a multi-annulus coagulation/fragmentation simulation that also includes the effect of size-dependent radial drift of planetesimals to determine the minimum size of initial planetesimal necessary for growth to large sizes in collisions. The minimum initial size of planetesimal necessary for growth depends greatly on the disk mass, eccentricity and the degree of apsidal alignment with the binary. We find that in a wide variety of situations, it is a reasonable approximation that growth occurs as long as there are no collisions capable of completely destroying a planetesimal, but erosion by moderately damaging collisions can also prevent growth from occurring.

Women's views and postpartum follow-up in the CHIPS Trial (Control of Hypertension in Pregnancy Study).

PubMed

Vidler, Marianne; Magee, Laura A; von Dadelszen, Peter; Rey, Evelyne; Ross, Susan; Asztalos, Elizabeth; Murphy, Kellie E; Menzies, Jennifer; Sanchez, Johanna; Singer, Joel; Gafni, Amiram; Gruslin, Andrée; Helewa, Michael; Hutton, Eileen; Lee, Shoo K; Lee, Terry; Logan, Alexander G; Ganzevoort, Wessel; Welch, Ross; Thornton, Jim G; Moutquin, Jean-Marie

2016-11-01

To compare women's views about blood pressure (BP) control in CHIPS (Control of Hypertension In Pregnancy Study) (NCT01192412). Quantitative and qualitative analysis of questionnaire responses. International randomised trial (94 sites, 15 countries). 911 (92.9%) women randomised to 'tight' (target diastolic blood pressure, 85mmHg) or 'less tight' (target diastolic blood pressure, 100mmHg) who completed questionnaires. A questionnaire was administered at ∼6-12 weeks postpartum regarding post-discharge morbidity and views about trial participation. Questionnaires were administered by the site co-ordinator, and contact was made by phone, home or clinic visit; rarely, data was collected from medical records. Quantitative analyses were Chi-square or Fisher's exact test for categorical variables, mixed effects multinomial logistic regression to adjust for confounders, and p<0.001 for statistical significance. NVivo software was used for thematic analysis of women's views. Satisfaction, measured as willingness to have the same treatment in another pregnancy or recommend that treatment to a friend. Among the 533 women in 'tight' (N=265) vs. 'less tight' (N=268) control who provided comments for qualitative analysis, women in 'tight' (vs. 'less tight') control made fewer positive comments about the amount of medication taken (5 vs. 28 women, respectively) and intensity of BP monitoring (7 vs. 17, respectively). However, this did not translate into less willingness to either have the same treatment in another pregnancy (434, 95.8% vs. 423, 92.4%, respectively; p=0.14) or recommend that treatment to a friend (435, 96.0% and 428, 93.4%, respectively; p=0.17). Importantly, although satisfaction remained high among women with an adverse outcome, those in 'tight' control who suffered an adverse outcome (vs. those who did not) were not consistently less satisfied, whereas this was not the case among women in 'less tight' control among whom satisfaction was consistently lower for the CHIPS primary outcome (p<0.001), severe hypertension (p≤0.01), and pre-eclampsia (p<0.001). Women in 'tight' (vs. 'less tight') control were equally satisfied with their care, and more so in the face of adverse perinatal or maternal outcomes. Copyright © 2016 The Author(s). Published by Elsevier Ireland Ltd.. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daugherty, W.; Mcwilliams, A.; Skidmore, E.

The 9975 Type B shipping package is used within the DOE complex for shipping special nuclear materials. This package is re-certified annually in accordance with Safety Analysis Report requirements. The package is also used at the Savannah River Site as part of the long-term storage configuration of special nuclear materials. As such, the packages do not undergo annual recertification during storage, with uncertainty as to how long some of the package components will meet their functional requirements in the storage environment. The packages are currently approved for up to 15 years storage, and work continues to provide a technical basismore » to extend that period. This paper describes efforts by the Savannah River National Laboratory (SRNL) to extend the service life estimate of Viton® GLT and GLT-S fluoroelastomer O-rings used in the 9975 shipping package. O-rings of both compositions are undergoing accelerated aging at elevated temperature, and are periodically tested for compression stress relaxation (CSR) behavior and leak performance. The CSR behavior of O-rings was evaluated at temperatures from 79 °C to 177 °C. These collective data were used to develop predictive models for extrapolation of CSR behavior to relevant service temperatures (< 75 °C). O-rings were also aged in Primary Containment Vessel (PCV) fixtures at temperatures ranging from 79 °C to 232 °C. The fixtures are helium leak tested periodically to determine if they remain leak-tight. The PCV fixture tests demonstrate that the 9975 O-rings will remain leak-tight at temperatures up to 149 °C for 3 years or more, and no leak failures have been observed with up to 8 years aging at 93 °C. Significantly longer periods of leak-tight service are expected at the lower temperatures actually experienced in the storage environment. The predictive model developed from the CSR data conservatively indicates a service life of more than 20 years at the bounding temperature of 75 °C. Although the relationship between CSR behavior and leak-tight performance has not been established for this design, the CSR predictions for this O-ring are conservative relative to leak-tight performance to date.« less

The Effects of Bicycle Frame Geometry on Muscle Activation and Power During a Wingate Anaerobic Test

PubMed Central

Ricard, Mark D.; Hills-Meyer, Patrick; Miller, Michael G.; Michael, Timothy J.

2006-01-01

The purpose of this study was to compare the effects of bicycle seat tube angles (STA) of (72° and 82°) on power production and EMG of the vastus laeralis (VL), vastus medialis (VM), semimembranous (SM), biceps femoris (BF) during a Wingate test (WAT). Twelve experienced cyclists performed a WAT at each STA. Repeated measures ANOVA was used to identify differences in muscular activation by STA. EMG variables were normalized to isometric maximum voluntary contraction (MVC). Paired t-tests were used to test the effects of STA on: peak power, average power, minimum power and percent power drop. Results indicated BF activation was significantly lower at STA 82° (482.9 ± 166.6 %MVC·s) compared to STA 72° (712.6 ± 265.6 %MVC·s). There were no differences in the power variables between STAs. The primary finding was that increasing the STA from 72° to 82° enabled triathletes’ to maintain power production, while significantly reducing the muscular activation of the biceps femoris muscle. Key Points Road cyclists claim that bicycle seat tube angles between 72° and 76° are most effective for optimal performance in racing. Triathletes typically use seat tube angles greater than 76°. It is thought that a seat tube angle greater than 76° facilitates a smoother bike to run transition in the triathlon. Increasing the seat tube angle from 72 to 82 enabled triathletes’ to maintain power production, while significantly reducing the muscular activation of the biceps femoris muscle. Reduced hamstring muscular activation in the triathlon frame (82 seat tube angle) may serve to reduce hamstring tightness following the bike phase of the triathlon, allowing the runner to use a longer stride length. PMID:24198678

An abstraction layer for efficient memory management of tabulated chemistry and flamelet solutions

NASA Astrophysics Data System (ADS)

Weise, Steffen; Messig, Danny; Meyer, Bernd; Hasse, Christian

2013-06-01

A large number of methods for simulating reactive flows exist, some of them, for example, directly use detailed chemical kinetics or use precomputed and tabulated flame solutions. Both approaches couple the research fields computational fluid dynamics and chemistry tightly together using either an online or offline approach to solve the chemistry domain. The offline approach usually involves a method of generating databases or so-called Lookup-Tables (LUTs). As these LUTs are extended to not only contain material properties but interactions between chemistry and turbulent flow, the number of parameters and thus dimensions increases. Given a reasonable discretisation, file sizes can increase drastically. The main goal of this work is to provide methods that handle large database files efficiently. A Memory Abstraction Layer (MAL) has been developed that handles requested LUT entries efficiently by splitting the database file into several smaller blocks. It keeps the total memory usage at a minimum using thin allocation methods and compression to minimise filesystem operations. The MAL has been evaluated using three different test cases. The first rather generic one is a sequential reading operation on an LUT to evaluate the runtime behaviour as well as the memory consumption of the MAL. The second test case is a simulation of a non-premixed turbulent flame, the so-called HM1 flame, which is a well-known test case in the turbulent combustion community. The third test case is a simulation of a non-premixed laminar flame as described by McEnally in 1996 and Bennett in 2000. Using the previously developed solver 'flameletFoam' in conjunction with the MAL, memory consumption and the performance penalty introduced were studied. The total memory used while running a parallel simulation was reduced significantly while the CPU time overhead associated with the MAL remained low.

42 CFR 84.156 - Airflow resistance test; Type C supplied-air respirator, demand class; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... C supplied-air respirator, demand class; minimum requirements. (a) Inhalation resistance shall not... 42 Public Health 1 2010-10-01 2010-10-01 false Airflow resistance test; Type C supplied-air respirator, demand class; minimum requirements. 84.156 Section 84.156 Public Health PUBLIC HEALTH SERVICE...

42 CFR 84.157 - Airflow resistance test; Type C supplied-air respirator, pressure-demand class; minimum...

Code of Federal Regulations, 2010 CFR

2010-10-01

... respirator, pressure-demand class; minimum requirements. 84.157 Section 84.157 Public Health PUBLIC HEALTH... test; Type C supplied-air respirator, pressure-demand class; minimum requirements. (a) The static... the facepiece shall not fall below atmospheric at inhalation airflows less than 115 liters (4 cubic...

42 CFR 84.157 - Airflow resistance test; Type C supplied-air respirator, pressure-demand class; minimum...

Code of Federal Regulations, 2011 CFR

2011-10-01

... respirator, pressure-demand class; minimum requirements. 84.157 Section 84.157 Public Health PUBLIC HEALTH... test; Type C supplied-air respirator, pressure-demand class; minimum requirements. (a) The static... the facepiece shall not fall below atmospheric at inhalation airflows less than 115 liters (4 cubic...

Precision grid and hand motion for accurate needle insertion in brachytherapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

McGill, Carl S.; Schwartz, Jonathon A.; Moore, Jason Z.

2011-08-15

Purpose: In prostate brachytherapy, a grid is used to guide a needle tip toward a preplanned location within the tissue. During insertion, the needle deflects en route resulting in target misplacement. In this paper, 18-gauge needle insertion experiments into phantom were performed to test effects of three parameters, which include the clearance between the grid hole and needle, the thickness of the grid, and the needle insertion speed. Measurement apparatus that consisted of two datum surfaces and digital depth gauge was developed to quantify needle deflections. Methods: The gauge repeatability and reproducibility (GR and R) test was performed on themore » measurement apparatus, and it proved to be capable of measuring a 2 mm tolerance from the target. Replicated experiments were performed on a 2{sup 3} factorial design (three parameters at two levels) and analysis included averages and standard deviation along with an analysis of variance (ANOVA) to find significant single and two-way interaction factors. Results: Results showed that grid with tight clearance hole and slow needle speed increased precision and accuracy of needle insertion. The tight grid was vital to enhance precision and accuracy of needle insertion for both slow and fast insertion speed; additionally, at slow speed the tight, thick grid improved needle precision and accuracy. Conclusions: In summary, the tight grid is important, regardless of speed. The grid design, which shows the capability to reduce the needle deflection in brachytherapy procedures, can potentially be implemented in the brachytherapy procedure.« less

Design verification test matrix development for the STME thrust chamber assembly

NASA Technical Reports Server (NTRS)

Dexter, Carol E.; Elam, Sandra K.; Sparks, David L.

1993-01-01

This report presents the results of the test matrix development for design verification at the component level for the National Launch System (NLS) space transportation main engine (STME) thrust chamber assembly (TCA) components including the following: injector, combustion chamber, and nozzle. A systematic approach was used in the development of the minimum recommended TCA matrix resulting in a minimum number of hardware units and a minimum number of hot fire tests.

Identification of two immortalized cell lines, ECV304 and bEnd3, for in vitro permeability studies of blood-brain barrier

PubMed Central

Mei, Shenghui; Jin, Hong; Zhu, Bin; Tian, Yue; Huo, Jiping; Cui, Xu; Guo, Anchen; Zhao, Zhigang

2017-01-01

To identify suitable cell lines for a mimetic system of in vivo blood-brain barrier (BBB) for drug permeability assessment, we characterized two immortalized cell lines, ECV304 and bEnd3 in the respect of the tightness, tight junction proteins, P-glycoprotein (P-gp) function and discriminative brain penetration. The ECV304 monoculture achieved higher transendothelial electrical resistance (TEER) and lower permeability to Lucifer yellow than bEnd3. However, co-culture with rat glioma C6 cells impaired the integrity of ECV304 and bEnd3 cell layers perhaps due to the heterogeneity among C6 cells in inducing BBB characteristics. The immunostaining of ZO-1 delivered distinct bands along cell borders on both cell lines while those of occludin and claudin-5 were diffused and weak. P-gp functionality was only proved in bEnd3 by Rhodamine 123 (R123) uptake assay. A permeability test of reference compounds displayed a similar rank order (digoxin < R123 < quinidine, verapamil < propranolol) in ECV304 and bEnd3 cells. In comparison with bEnd3, ECV304 developed tighter barrier for the passage of reference compounds and higher discrimination between transcellular and paracellular transport. However, the monoculture models of ECV304 and bEnd3 fail to achieve the sufficient tightness of in vitro BBB permeability models with high TEER and evident immunostaining of tight junction proteins. Further strategies to enhance the paracellular tightness of both cell lines to mimic in vivo BBB tight barrier deserve to be conducted. PMID:29059256

Identification of two immortalized cell lines, ECV304 and bEnd3, for in vitro permeability studies of blood-brain barrier.

PubMed

Yang, Shu; Mei, Shenghui; Jin, Hong; Zhu, Bin; Tian, Yue; Huo, Jiping; Cui, Xu; Guo, Anchen; Zhao, Zhigang

2017-01-01

To identify suitable cell lines for a mimetic system of in vivo blood-brain barrier (BBB) for drug permeability assessment, we characterized two immortalized cell lines, ECV304 and bEnd3 in the respect of the tightness, tight junction proteins, P-glycoprotein (P-gp) function and discriminative brain penetration. The ECV304 monoculture achieved higher transendothelial electrical resistance (TEER) and lower permeability to Lucifer yellow than bEnd3. However, co-culture with rat glioma C6 cells impaired the integrity of ECV304 and bEnd3 cell layers perhaps due to the heterogeneity among C6 cells in inducing BBB characteristics. The immunostaining of ZO-1 delivered distinct bands along cell borders on both cell lines while those of occludin and claudin-5 were diffused and weak. P-gp functionality was only proved in bEnd3 by Rhodamine 123 (R123) uptake assay. A permeability test of reference compounds displayed a similar rank order (digoxin < R123 < quinidine, verapamil < propranolol) in ECV304 and bEnd3 cells. In comparison with bEnd3, ECV304 developed tighter barrier for the passage of reference compounds and higher discrimination between transcellular and paracellular transport. However, the monoculture models of ECV304 and bEnd3 fail to achieve the sufficient tightness of in vitro BBB permeability models with high TEER and evident immunostaining of tight junction proteins. Further strategies to enhance the paracellular tightness of both cell lines to mimic in vivo BBB tight barrier deserve to be conducted.

Proceedings of the Symposium on Minimum Competency Testing (Philadelphia, Pennsylvania, October 24-25, 1979).

ERIC Educational Resources Information Center

Mid-Atlantic Teacher Corps Network, Philadelphia, PA.

The conference's keynote address is presented by Bernard C. Watson. Papers include: Vantage from the State Department of Education, by Robert G. Scanlon (Pennsylvania); Minimum Competency: As the Public Sees the Question, by Jacqueline Grennan Wexler; Minimum Competency Testing (MCT): A Tripartite Response from the Profession, by W. James Popham;…

The minimum test battery to screen for binocular vision anomalies: report 3 of the BAND study.

PubMed

Hussaindeen, Jameel Rizwana; Rakshit, Archayeeta; Singh, Neeraj Kumar; Swaminathan, Meenakshi; George, Ronnie; Kapur, Suman; Scheiman, Mitchell; Ramani, Krishna Kumar

2018-03-01

This study aims to report the minimum test battery needed to screen non-strabismic binocular vision anomalies (NSBVAs) in a community set-up. When large numbers are to be screened we aim to identify the most useful test battery when there is no opportunity for a more comprehensive and time-consuming clinical examination. The prevalence estimates and normative data for binocular vision parameters were estimated from the Binocular Vision Anomalies and Normative Data (BAND) study, following which cut-off estimates and receiver operating characteristic curves to identify the minimum test battery have been plotted. In the receiver operating characteristic phase of the study, children between nine and 17 years of age were screened in two schools in the rural arm using the minimum test battery, and the prevalence estimates with the minimum test battery were found. Receiver operating characteristic analyses revealed that near point of convergence with penlight and red filter (> 7.5 cm), monocular accommodative facility (< 10 cycles per minute), and the difference between near and distance phoria (> 1.25 prism dioptres) were significant factors with cut-off values for best sensitivity and specificity. This minimum test battery was applied to a cohort of 305 children. The mean (standard deviation) age of the subjects was 12.7 (two) years with 121 males and 184 females. Using the minimum battery of tests obtained through the receiver operating characteristic analyses, the prevalence of NSBVAs was found to be 26 per cent. Near point of convergence with penlight and red filter > 10 cm was found to have the highest sensitivity (80 per cent) and specificity (73 per cent) for the diagnosis of convergence insufficiency. For the diagnosis of accommodative infacility, monocular accommodative facility with a cut-off of less than seven cycles per minute was the best predictor for screening (92 per cent sensitivity and 90 per cent specificity). The minimum test battery of near point of convergence with penlight and red filter, difference between distance and near phoria, and monocular accommodative facility yield good sensitivity and specificity for diagnosis of NSBVAs in a community set-up. © 2017 Optometry Australia.

Minimum Dimension of a Hilbert Space Needed to Generate a Quantum Correlation.

PubMed

Sikora, Jamie; Varvitsiotis, Antonios; Wei, Zhaohui

2016-08-05

Consider a two-party correlation that can be generated by performing local measurements on a bipartite quantum system. A question of fundamental importance is to understand how many resources, which we quantify by the dimension of the underlying quantum system, are needed to reproduce this correlation. In this Letter, we identify an easy-to-compute lower bound on the smallest Hilbert space dimension needed to generate a given two-party quantum correlation. We show that our bound is tight on many well-known correlations and discuss how it can rule out correlations of having a finite-dimensional quantum representation. We show that our bound is multiplicative under product correlations and also that it can witness the nonconvexity of certain restricted-dimensional quantum correlations.

Bounds on quantum communication via Newtonian gravity

NASA Astrophysics Data System (ADS)

Kafri, D.; Milburn, G. J.; Taylor, J. M.

2015-01-01

Newtonian gravity yields specific observable consequences, the most striking of which is the emergence of a 1/{{r}2} force. In so far as communication can arise via such interactions between distant particles, we can ask what would be expected for a theory of gravity that only allows classical communication. Many heuristic suggestions for gravity-induced decoherence have this restriction implicitly or explicitly in their construction. Here we show that communication via a 1/{{r}2} force has a minimum noise induced in the system when the communication cannot convey quantum information, in a continuous time analogue to Bell's inequalities. Our derived noise bounds provide tight constraints from current experimental results on any theory of gravity that does not allow quantum communication.

Hypersonic vehicle control law development using H(infinity) and micron-synthesis

NASA Technical Reports Server (NTRS)

Gregory, Irene M.; Mcminn, John D.; Shaughnessy, John D.; Chowdhry, Rajiv S.

1993-01-01

Hypersonic vehicle control law development using H(infinity) and mu-synthesis is discussed. Airbreathing SSTO vehicles has a mutli-faceted mission that includes orbital operations, as well as re-entry and descent culminating in horizontal landing. However, the most challenging part of the operations is the ascent to orbit. The airbreathing propulsion requires lengthy atmospheric flight that may last as long as 30 minutes and take the vehicle half way around the globe. The vehicles's ascent is characterized by tight payload to orbit margins which translate into minimum fuel orbit as the performance criteria. Issues discussed include: SSTO airbreathing vehicle issues; control system performance requirements; robust control law framework; H(infinity) controller frequency analysis; and mu controller frequency analysis.

78 FR 4855 - Random Drug Testing Rate for Covered Crewmembers

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-23

... DEPARTMENT OF HOMELAND SECURITY Coast Guard [Docket No. USCG-2009-0973] Random Drug Testing Rate for Covered Crewmembers AGENCY: Coast Guard, DHS. ACTION: Notice of minimum random drug testing rate. SUMMARY: The Coast Guard has set the calendar year 2013 minimum random drug testing rate at 25 percent of...

76 FR 79204 - Random Drug Testing Rate for Covered Crewmembers

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-21

... DEPARTMENT OF HOMELAND SECURITY Coast Guard [Docket No. USCG-2009-0973] Random Drug Testing Rate for Covered Crewmembers AGENCY: Coast Guard, DHS. ACTION: Notice of minimum random drug testing rate. SUMMARY: The Coast Guard has set the calendar year 2012 minimum random drug testing rate at 50 percent of...

76 FR 1448 - Random Drug Testing Rate for Covered Crewmembers

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-10

... DEPARTMENT OF HOMELAND SECURITY Coast Guard [Docket No. USCG-2009-0973] Random Drug Testing Rate for Covered Crewmembers AGENCY: Coast Guard, DHS. ACTION: Notice of minimum random drug testing rate. SUMMARY: The Coast Guard has set the calendar year 2011 minimum random drug testing rate at 50 percent of...

46 CFR 164.023-13 - Production tests and inspections.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Constant Rate of Traverse tensile testing machine, capable of initial clamp separation of ten inches and a... the acceptance testing values but not less than the performance minimums. (2) Length/weight values must be within 5 percent of the acceptance testing values but not less than the performance minimums...

Higher Accuracy of the Lactate Minimum Test Compared to Established Threshold Concepts to Determine Maximal Lactate Steady State in Running.

PubMed

Wahl, Patrick; Zwingmann, Lukas; Manunzio, Christian; Wolf, Jacob; Bloch, Wilhelm

2018-05-18

This study evaluated the accuracy of the lactate minimum test, in comparison to a graded-exercise test and established threshold concepts (OBLA and mDmax) to determine running speed at maximal lactate steady state. Eighteen subjects performed a lactate minimum test, a graded-exercise test (2.4 m·s -1 start,+0.4 m·s -1 every 5 min) and 2 or more constant-speed tests of 30 min to determine running speed at maximal lactate steady state. The lactate minimum test consisted of an initial lactate priming segment, followed by a short recovery phase. Afterwards, the initial load of the subsequent incremental segment was individually determined and was increased by 0.1 m·s -1 every 120 s. Lactate minimum was determined by the lowest measured value (LM abs ) and by a third-order polynomial (LM pol ). The mean difference to maximal lactate steady state was+0.01±0.14 m·s -1 (LM abs ), 0.04±0.15 m·s -1 (LM pol ), -0.06±0.31 m·s 1 (OBLA) and -0.08±0.21 m·s 1 (mDmax). The intraclass correlation coefficient (ICC) between running velocity at maximal lactate steady state and LM abs was highest (ICC=0.964), followed by LM pol (ICC=0.956), mDmax (ICC=0.916) and OBLA (ICC=0.885). Due to the higher accuracy of the lactate minimum test to determine maximal lactate steady state compared to OBLA and mDmax, we suggest the lactate minimum test as a valid and meaningful concept to estimate running velocity at maximal lactate steady state in a single session for moderately up to well-trained athletes. © Georg Thieme Verlag KG Stuttgart · New York.

Ceramic-to-Metal Joining for High Temperature, High Pressure Heat Exchangers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mako, Frederick; Mako III, Frederick

2016-12-05

Designed and tested silicon carbide to metal joining and silicon carbide joining technology under high temperature and high pressure conditions. Determined that the joints maintained integrity and remained helium gas tight. These joined parts have been tested for mechanical strength, fracture toughness and hermeticity. A component testing chamber was designed and built and used for testing the joint integrity.

Nanofiltration and Tight Ultrafiltration Membranes for Natural Organic Matter Removal—Contribution of Fouling and Concentration Polarization to Filtration Resistance

PubMed Central

Winter, Joerg; Bérubé, Pierre

2017-01-01

Nanofiltration (NF) and tight ultrafiltration (tight UF) membranes are a viable treatment option for high quality drinking water production from sources with high concentrations of contaminants. To date, there is limited knowledge regarding the contribution of concentration polarization (CP) and fouling to the increase in resistance during filtration of natural organic matter (NOM) with NF and tight UF. Filtration tests were conducted with NF and tight UF membranes with molecular weight cut offs (MWCOs) of 300, 2000 and 8000 Da, and model raw waters containing different constituents of NOM. When filtering model raw waters containing high concentrations of polysaccharides (i.e., higher molecular weight NOM), the increase in resistance was dominated by fouling. When filtering model raw waters containing humic substances (i.e., lower molecular weight NOM), the increase in filtration resistance was dominated by CP. The results indicate that low MWCO membranes are better suited for NOM removal, because most of the NOM in surface waters consist mainly of humic substances, which were only effectively rejected by the lower MWCO membranes. However, when humic substances are effectively rejected, CP can become extensive, leading to a significant increase in filtration resistance by the formation of a cake/gel layer at the membrane surface. For this reason, cross-flow operation, which reduces CP, is recommended. PMID:28671604

75 FR 16813 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-02

... Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for Federal... Drug Testing Programs (Mandatory Guidelines). The Mandatory Guidelines were first published in the... of [[Page 16814

Galileo battery testing and the impact of test automation

NASA Technical Reports Server (NTRS)

Pertuch, W. T.; Dils, C. T.

1985-01-01

Test complexity, changes of test specifications, and the demand for tight control of tests led to the development of automated testing used for Galileo and other projects. The use of standardized interfacing, i.e., IEEE-488, with desktop computers and test instruments, resulted in greater reliability, repeatability, and accuracy of both control and data reporting. Increased flexibility of test programming has reduced costs by permitting a wide spectrum of test requirements at one station rather than many stations.

Tight Fits for Americas Next Moon Rocket, Ares V

NASA Technical Reports Server (NTRS)

Jaap, John; Fisher, Wyatt; Richardson, Lea

2010-01-01

America has begun the development of a new heavy lift rocket which will enable humans to return to the moon and reach even farther destinations. Five decades ago, the National Aeronautics and Space Administration designed a system (called Saturn/Apollo) to carry men to the moon and back; the rocket which boosted them to the moon was the Saturn V. Saturn V was huge relative to contemporary rockets and is still the largest rocket ever launched. The new moon rocket is called Ares V. It will insert 40% more payload into low earth orbit than Saturn V; and after docking with the crew spacecraft, it will insert 50% more payload onto the translunar trajectory than Saturn V. The current design of Ares V calls for two liquid-fueled stages and 2 "strap-on" solid rockets. The solid rockets are extended-length versions of the solid rockets used on the Shuttle. The diameter of the liquid stages is at least as large as the first stage of the Saturn V; the height of the lower liquid stage (called the core stage) is longer than the external tank of the Shuttle. Huge rockets require huge infrastructure and, during the Saturn/Apollo era, America invested significantly in manufacturing, assembly and launch facilities which are still in use today. Since the Saturn/Apollo era, America has invested in additional infrastructure for the Shuttle program. Ares V must utilize this existing infrastructure, with reasonable modifications. Building a rocket with 50% more capability in the same buildings, testing it in the same test stands, shipping on the same canals under the same bridges, assembling it in the same building, rolling it to the pad on the same crawler, and launching it from the same launch pad is an engineering and logistics challenge which goes hand-in-hand with designing the structure, tanks, turbines, engines, software, etc. necessary to carry such a large payload to earth orbit and to the moon. This paper quantitatively discusses the significant "tight fits" that are constraining Ares V. The engineers designing and building the infrastructure for the Saturn/Apollo program usually added margins and growth capability; sometimes the size of existing facilities (such as the width of a draw bridge) was not a constraint. Ares V may utilize the "extra" space in the existing facilities and expand other tight fits. Some of the tight fits cannot be overcome without great expense; raising the roof on the Vertical Assembly Building for example. Other tight fits are easily overcome; the transporter at the manufacturing facility for the core stage can pass under low ceilings and later over a dike (without dragging the middle) by retracting or extending the struts which support the stage. Tight fits discussed in this paper include manufacturing (jigs, widths, heights, and local transportation), testing (test stand sizes and crane capability), transportation to the test stands and the launch site (barge, waterway, and rail), assembly (VAB internal dimensions and door size), roll-out limits, and launch pad size.

75 FR 75485 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-03

... Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for Federal... Guidelines for Federal Workplace Drug Testing Programs (Mandatory Guidelines). The Mandatory Guidelines were... Laboratories and Instrumented Initial Testing Facilities (IITF) must meet in order to conduct drug and specimen...

75 FR 39023 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-07

... Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for Federal... Drug Testing Programs (Mandatory Guidelines). The Mandatory Guidelines were first published in the... of Laboratories Engaged in Urine Drug Testing for Federal Agencies,'' sets strict standards that...

75 FR 27348 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-14

... Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for Federal... Drug Testing Programs (Mandatory Guidelines). The Mandatory Guidelines were first published in the... of Laboratories Engaged in Urine Drug Testing for Federal Agencies,'' sets strict standards that...

75 FR 62842 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-13

... Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for Federal... Guidelines for Federal Workplace Drug Testing Programs (Mandatory Guidelines). The Mandatory Guidelines were... and Instrumented Initial Testing Facilities (IITF) must meet in order to conduct drug and specimen...

75 FR 9229 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-01

... Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for Federal... Drug Testing Programs (Mandatory Guidelines). The Mandatory Guidelines were first published in the... of Laboratories Engaged in Urine Drug Testing for Federal Agencies,'' sets strict standards that...

75 FR 5088 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-01

... Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for Federal... Drug Testing Programs (Mandatory Guidelines). The Mandatory Guidelines were first published in the... of Laboratories Engaged in Urine Drug Testing for Federal Agencies,'' sets strict standards that...

75 FR 154 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-04

... Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for Federal... Drug Testing Programs (Mandatory Guidelines). The Mandatory Guidelines were first published in the... of Laboratories Engaged in Urine Drug Testing for Federal Agencies,'' sets strict standards that...

75 FR 45128 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-02

... Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for Federal... Drug Testing Programs (Mandatory Guidelines). The Mandatory Guidelines were first published in the..., ``Certification of Laboratories Engaged in Urine Drug Testing for Federal Agencies,'' sets strict standards that...

75 FR 32950 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-10

... Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for Federal... Drug Testing Programs (Mandatory Guidelines). The Mandatory Guidelines were first published in the... of Laboratories Engaged in Urine Drug Testing for Federal Agencies,'' sets strict standards that...

75 FR 55795 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-14

... Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for Federal... Drug Testing Programs (Mandatory Guidelines). The Mandatory Guidelines were first published in the... of Laboratories Engaged in Urine Drug Testing for Federal Agencies,'' sets strict standards that...

Combined-probability space and certainty or uncertainty relations for a finite-level quantum system

NASA Astrophysics Data System (ADS)

Sehrawat, Arun

2017-08-01

The Born rule provides a probability vector (distribution) with a quantum state for a measurement setting. For two settings, we have a pair of vectors from the same quantum state. Each pair forms a combined-probability vector that obeys certain quantum constraints, which are triangle inequalities in our case. Such a restricted set of combined vectors, called the combined-probability space, is presented here for a d -level quantum system (qudit). The combined space is a compact convex subset of a Euclidean space, and all its extreme points come from a family of parametric curves. Considering a suitable concave function on the combined space to estimate the uncertainty, we deliver an uncertainty relation by finding its global minimum on the curves for a qudit. If one chooses an appropriate concave (or convex) function, then there is no need to search for the absolute minimum (maximum) over the whole space; it will be on the parametric curves. So these curves are quite useful for establishing an uncertainty (or a certainty) relation for a general pair of settings. We also demonstrate that many known tight certainty or uncertainty relations for a qubit can be obtained with the triangle inequalities.

Hydro-mechanical properties of the Red Salt Clay (T4) - Relevancy of the minimum stress criterion for barrier integrity

NASA Astrophysics Data System (ADS)

Minkley, W.; Popp, T.; Salzer, K.; Gruner, M.; Böttge, V.

The so-called Red Salt Clay (T4) is deposited as clay-rich clastic sediment at the base of the Aller-series forming a persistent lateral layer of up to 20 m thickness above the lower Zechstein-series. The clay layers may act as a protective shield in the hanging wall of gas storages or underground repositories in salt formations, thus resulting in a multi-barrier system. As a proof of its reliability comprehensive hydro-mechanical investigations were performed on clay samples recovered at different sites in Germany. Most important, rock tightness against various fluids was confirmed in the lab and field-scale. Remarkably, only if the fluid pressure equalises the acting minimal stress (i.e. violence of the “minimum stress criterion”) a significant increase of permeability is observed (“pathway dilatation”) but no macro-frac. However, the material properties from different locations showed a significant variability according to different burial depths. Thus the Red Salt Clay may act as natural analogue, representing the material variability of various indurated clays. In addition, the existing knowledge gained from practical mining activities can be used to evaluate extreme in situ loading conditions.

SB certification handout material requirements, test methods, responsibilities, and minimum classification levels for mixture-based specification for flexible base.

DOT National Transportation Integrated Search

2012-10-01

A handout with tables representing the material requirements, test methods, responsibilities, and minimum classification levels mixture-based specification for flexible base and details on aggregate and test methods employed, along with agency and co...

Flow balancing orifice for ITER toroidal field coil

NASA Astrophysics Data System (ADS)

Litvinovich, A. V.; Y Rodin, I.; Kovalchuk, O. A.; Safonov, A. V.; Stepanov, D. B.; Guryeva, T. M.

2017-12-01

Flow balancing orifices (FBOs) are used in in International thermonuclear experimental reactor (ITER) Toroidal Field coil to uniform flow rate of cooling gas in the side double pancakes which have a different conductor length: 99 m and 305 m, respectively. FBOs consist of straight parts, elbows produced from a 316L stainless steel tube 21.34 x 2.11 mm and orifices made from a 316L stainless steel rod. Each of right and left FBOs contains 6 orifices, straight FBOs contain 4 and 6 orifices. Before manufacturing of qualification samples D.V. Efremov Institute of Electrophysical Apparatus (JSC NIIEFA) proposed to ITER a new approach to provide the seamless connection between a tube and a plate therefore the most critical weld between the orifice with 1 mm thickness and the tube removed from the FBOs final design. The proposed orifice diameter is three times less than the minimum requirement of the ISO 5167, therefore it was tasked to define accuracy of calculation flow characteristics at room temperature and compare with the experimental data. In 2015 the qualification samples of flow balancing orifices were produced and tested. The results of experimental data showed that the deviation of calculated data is less than 7%. Based on this result and other tests ITER approved the design of FBOs, which made it possible to start the serial production. In 2016 JSC NIIEFA delivered 50 FBOs to ITER, i.e. 24 left side, 24 right side and 2 straight FBOs. In order to define the quality of FBOs the test facility in JSC NIIEFA was prepared. The helium tightness test at 10-9 m3·Pa/s the pressure up to 3 MPa, flow rate measuring at the various pressure drops, the non-destructive tests of orifices and weld seams (ISO 5817, class B) were conducted. Other tests such as check dimensions and thermo cycling 300 - 80 - 300 K also were carried out for each FBO.

Dry-vault storage of spent fuel at the CASCAD facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baillif, L.; Guay, M.

A new modular dry storage vault concept using vertical metallic wells cooled by natural convection has been developed by the Commissariat a l'Energie Atomique and Societe Generale pour les Techniques Nouvelles to accommodate special fuels for high-level wastes. Basic specifications and design criteria have been followed to guarantee a double containment system and cooling to maintain the fuel below an acceptable temperature. The double containment is provided by two static barriers: At the reactor, fuels are placed in containers playing the role of the first barrier; the storage wells constitute the second barrier. Spent fuel placed in wells is cooledmore » by natural convection: a boundary layer is created along the outer side of the well. The heated air rises along the well leading to a thermosiphon flow that extracts the heat released. For heat transfer, studies, computations, and experimental tests have been carried out to calculate and determine the temperature of the containers and the fuel rod temperatures in various situations. The CASCAD vault storage can be applied to light water reactor (LWR) fuels without any difficulties if two requirements are satisfied: (1) Spend fuels have to be inserted in tight canisters. (2) Spent fuels have to be received only after a minimum decay time of 5 yr.« less

Jack-knife stretching promotes flexibility of tight hamstrings after 4 weeks: a pilot study.

PubMed

Sairyo, Koichi; Kawamura, Takeshi; Mase, Yasuyoshi; Hada, Yasushi; Sakai, Toshinori; Hasebe, Kiyotaka; Dezawa, Akira

2013-08-01

Tight hamstrings are reported to be one of the causes of low back pain. However, there have been few reports on effective stretching procedures for the tight hamstrings. The so-called jack-knife stretch, an active-static type of stretching, can efficiently increase the flexibility of tight hamstrings. To evaluate hamstring tightness before and after the 4-week stretching protocol in healthy volunteer adults and patients aged under 18 years with low back pain. For understanding the hamstrings tightness, we measured two parameters including (1) finger to floor distance (FFD) and (2) pelvis forward inclination angle (PFIA). Eight healthy adult volunteers who had no lumbar or hip problems participated in this study (mean age: 26.8 years). All lacked flexibility and their FFD were positive before the experiment. Subjects performed 2 sets of the jack-knife stretch every day for 4 weeks. One set consisted of 5 repetitions, each held for 5 s. Before and during the 4-week experiment, the FFD and PFIA of toe-touching tests were measured weekly. For 17 of the sports players aged under 18, only FFD was measured. In adult volunteers, FFD was 14.1 ± 6.1 cm before the experiment and decreased to -8.1 ± 3.7 cm by the end of week 4, indicating a gain in flexibility of 22.2 cm. PFIA was 50.6 ± 8.2 before the experiment and 83.8 ± 5.8 degrees after. Before and after the experiment, the differences were significant (p < 0.05). For those aged under 18, FFD was 8.1 ± 8.0 and -9.6 ± 6.8, before and after the stretching, respectively. This difference was significant (p < 0.05). The jack-knife stretch is a useful active-static stretching technique to efficiently increase flexibility of tight hamstrings.

Coronal plane radiographic evaluation of the single TightRope technique in the treatment of acute acromioclavicular joint injury.

PubMed

Yi, Young; Kim, Jeong Woo

2015-10-01

This study aimed to demonstrate the technical aspects of the single TightRope (Arthrex, Naples, FL, USA) procedure for acute acromioclavicular-coracoclavicular joint dislocation, identify the predictive factors influencing its outcome, and assess and validate the significance of specific radiologic parameters. We reviewed true anteroposterior shoulder radiographs of 62 consecutive patients who had undergone surgical reconstruction using TightRope for an acute acromioclavicular-coracoclavicular injury. All patients were followed up for at least 12 months between October 2009 and March 2012 and were divided into dissociated or nondissociated groups according to their surgical outcome. We measured the clavicle tunnel anteroposterior angle, distal clavicular tunnel placement, and tunnel-to-medial coracoid ratio, and compared the parameters in each group after a satisfactory intraclass correlation coefficient reliability test result. The angles of patients in the dissociated group were more acute compared with the angles of those in the nondissociated group, which were perpendicular, as verified statistically using the paired t test. The difference in the distal clavicular tunnel placement and tunnel-to-medial coracoid ratio between the groups was not significant. Therefore, tunnel placement is not influenced by coracoclavicular dissociation. The clavicle tunnel anteroposterior angle can be used as a predictor of surgical outcome in coracoclavicular augmentation surgery. The surgeon should strive to place a perpendicular hole from the clavicle to the coracoid process for the TightRope fixation to enable a successful reconstruction of the acute acromioclavicular-coracoclavicular injury. Copyright © 2015 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

Setting Standards for Minimum Competency Tests.

ERIC Educational Resources Information Center

Mehrens, William A.

Some general questions about minimum competency tests are discussed, and various methods of setting standards are reviewed with major attention devoted to those methods used for dichotomizing a continuum. Methods reviewed under the heading of Absolute Judgments of Test Content include Nedelsky's, Angoff's, Ebel's, and Jaeger's. These methods are…

42 CFR 84.206 - Particulate tests; respirators with filters; minimum requirements; general.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Particulate tests; respirators with filters... filters; minimum requirements; general. (a) Three respirators with cartridges containing, or having attached to them, filters for protection against particulates will be tested in accordance with the...

42 CFR 84.206 - Particulate tests; respirators with filters; minimum requirements; general.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Particulate tests; respirators with filters... filters; minimum requirements; general. (a) Three respirators with cartridges containing, or having attached to them, filters for protection against particulates will be tested in accordance with the...

42 CFR 84.206 - Particulate tests; respirators with filters; minimum requirements; general.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Particulate tests; respirators with filters... filters; minimum requirements; general. (a) Three respirators with cartridges containing, or having attached to them, filters for protection against particulates will be tested in accordance with the...

42 CFR 84.206 - Particulate tests; respirators with filters; minimum requirements; general.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Particulate tests; respirators with filters... filters; minimum requirements; general. (a) Three respirators with cartridges containing, or having attached to them, filters for protection against particulates will be tested in accordance with the...

42 CFR 84.206 - Particulate tests; respirators with filters; minimum requirements; general.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Particulate tests; respirators with filters... filters; minimum requirements; general. (a) Three respirators with cartridges containing, or having attached to them, filters for protection against particulates will be tested in accordance with the...

Student Minimum Competency Testing. Issuegram 20.

ERIC Educational Resources Information Center

Pipho, Chris

This brief report states that recent emphasis on minimum competency testing has been on using the test results to make better decisions for improving the instructional program and providing remediation. State and local school districts, using advisory committees and commissions, are in various stages of identifying instructional goals and…

Item Specifications, Science Grade 8. Blue Prints for Testing Minimum Performance Test.

ERIC Educational Resources Information Center

Arkansas State Dept. of Education, Little Rock.

These item specifications were developed as a part of the Arkansas "Minimum Performance Testing Program" (MPT). There is one item specification for each instructional objective included in the MPT. The purpose of an item specification is to provide an overview of the general content and format of test items used to measure an…

Item Specifications, Science Grade 6. Blue Prints for Testing Minimum Performance Test.

ERIC Educational Resources Information Center

Arkansas State Dept. of Education, Little Rock.

These item specifications were developed as a part of the Arkansas "Minimum Performance Testing Program" (MPT). There is one item specification for each instructional objective included in the MPT. The purpose of an item specification is to provide an overview of the general content and format of test items used to measure an…

Development of an accelerated reliability test schedule for terrestrial solar cells

NASA Technical Reports Server (NTRS)

Lathrop, J. W.; Prince, J. L.

1981-01-01

An accelerated test schedule using a minimum amount of tests and a minimum number of cells has been developed on the basis of stress test results obtained from more than 1500 cells of seven different cell types. The proposed tests, which include bias-temperature, bias-temperature-humidity, power cycle, thermal cycle, and thermal shock tests, use as little as 10 and up to 25 cells, depending on the test type.

Influence of Hamstring Tightness in Pelvic, Lumbar and Trunk Range of Motion in Low Back Pain and Asymptomatic Volunteers during Forward Bending

PubMed Central

Macedo, Adriana Ribeiro

2015-01-01

Study Design Cross-sectional study. Purpose To verify the association of hamstring tightness and range of motion in anterior pelvic tilt (PT), lumbar motion (LM), and trunk flexion (TF) during forward bending. Overview of Literature Increased hamstring stiffness could be a possible contributing factor to low back injuries. Clinical observations have suggested that hamstring tightness influences lumbar pelvic rhythm. Movement restrictions or postural asymmetry likely lead to compensatory movement patterns of the lumbar spine, and subsequently to increased stress on the spinal soft tissues and an increased risk of low back pain (LBP). Methods Hamstring muscle tightness was measured using the self-monitored active knee extension (AKE) test. A bubble inclinometer was used to determine the range of motion of PT, LM, and TF during forward bending. Statistical analysis included descriptive statistics, comparisons between groups and a correlation between hamstring tightness (AKE) and anterior PT, TF, and regional LM with p≤0.05. Results The LBP group was composed of 36 participants, and the asymptomatic group consisted of 32 participants. The mean for PT in the control group was 66.7°, 64.5° for LM and 104.6° for TF. Respective values in the symptomatic group were 57.0°, 79.8°, and 82.2°. Conclusions Participants with LBP showed restriction in the pelvis and TF range of motion, but had higher amplitudes in the lumbar spine during forward bending. PMID:26240711

Influence of Hamstring Tightness in Pelvic, Lumbar and Trunk Range of Motion in Low Back Pain and Asymptomatic Volunteers during Forward Bending.

PubMed

Jandre Reis, Felipe Jose; Macedo, Adriana Ribeiro

2015-08-01

Cross-sectional study. To verify the association of hamstring tightness and range of motion in anterior pelvic tilt (PT), lumbar motion (LM), and trunk flexion (TF) during forward bending. Increased hamstring stiffness could be a possible contributing factor to low back injuries. Clinical observations have suggested that hamstring tightness influences lumbar pelvic rhythm. Movement restrictions or postural asymmetry likely lead to compensatory movement patterns of the lumbar spine, and subsequently to increased stress on the spinal soft tissues and an increased risk of low back pain (LBP). Hamstring muscle tightness was measured using the self-monitored active knee extension (AKE) test. A bubble inclinometer was used to determine the range of motion of PT, LM, and TF during forward bending. Statistical analysis included descriptive statistics, comparisons between groups and a correlation between hamstring tightness (AKE) and anterior PT, TF, and regional LM with p≤0.05. The LBP group was composed of 36 participants, and the asymptomatic group consisted of 32 participants. The mean for PT in the control group was 66.7°, 64.5° for LM and 104.6° for TF. Respective values in the symptomatic group were 57.0°, 79.8°, and 82.2°. Participants with LBP showed restriction in the pelvis and TF range of motion, but had higher amplitudes in the lumbar spine during forward bending.

Intraoperative tight glucose control using hyperinsulinemic normoglycemia increases delirium after cardiac surgery.

PubMed

Saager, Leif; Duncan, Andra E; Yared, Jean-Pierre; Hesler, Brian D; You, Jing; Deogaonkar, Anupa; Sessler, Daniel I; Kurz, Andrea

2015-06-01

Postoperative delirium is common in patients recovering from cardiac surgery. Tight glucose control has been shown to reduce mortality and morbidity. Therefore, the authors sought to determine the effect of tight intraoperative glucose control using a hyperinsulinemic-normoglycemic clamp approach on postoperative delirium in patients undergoing cardiac surgery. The authors enrolled 198 adult patients having cardiac surgery in this randomized, double-blind, single-center trial. Patients were randomly assigned to either tight intraoperative glucose control with a hyperinsulinemic-normoglycemic clamp (target blood glucose, 80 to 110 mg/dl) or standard therapy (conventional insulin administration with blood glucose target, <150 mg/dl). Delirium was assessed using a comprehensive delirium battery. The authors considered patients to have experienced postoperative delirium when Confusion Assessment Method testing was positive at any assessment. A positive Confusion Assessment Method was defined by the presence of features 1 (acute onset and fluctuating course) and 2 (inattention) and either 3 (disorganized thinking) or 4 (altered consciousness). Patients randomized to tight glucose control were more likely to be diagnosed as being delirious than those assigned to routine glucose control (26 of 93 vs. 15 of 105; relative risk, 1.89; 95% CI, 1.06 to 3.37; P = 0.03), after adjusting for preoperative usage of calcium channel blocker and American Society of Anesthesiologist physical status. Delirium severity, among patients with delirium, was comparable with each glucose management strategy. Intraoperative hyperinsulinemic-normoglycemia augments the risk of delirium after cardiac surgery, but not its severity.

Flange joint system for SRF cavities utilizing high force spring clamps for low particle generation

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

A flange joint system for SRF cavities. The flange joint system includes a set of high force spring clamps that produce high force on the simple flanges of Superconducting Radio Frequency (SRF) cavities to squeeze conventional metallic seals. The system establishes the required vacuum and RF-tight seal with minimum particle contamination to the inside of the cavity assembly. The spring clamps are designed to stay within their elastic range while being forced open enough to mount over the flange pair. Upon release, the clamps have enough force to plastically deform metallic seal surfaces and continue to a new equilibrium sprungmore » dimension where the flanges remain held against one another with enough preload such that normal handling will not break the seal.« less

Site-controlled quantum dots fabricated using an atomic-force microscope assisted technique

PubMed Central

Usuki, T; Ohshima, T; Sakuma, Y; Kawabe, M; Okada, Y; Takemoto, K; Miyazawa, T; Hirose, S; Nakata, Y; Takatsu, M; Yokoyama, N

2006-01-01

An atomic-force microscope assisted technique is developed to control the position and size of self-assembled semiconductor quantum dots (QDs). Presently, the site precision is as good as ± 1.5 nm and the size fluctuation is within ± 5% with the minimum controllable lateral diameter of 20 nm. With the ability of producing tightly packed and differently sized QDs, sophisticated QD arrays can be controllably fabricated for the application in quantum computing. The optical quality of such site-controlled QDs is found comparable to some conventionally self-assembled semiconductor QDs. The single dot photoluminescence of site-controlled InAs/InP QDs is studied in detail, presenting the prospect to utilize them in quantum communication as precisely controlled single photon emitters working at telecommunication bands.

Simple Refractometers for Index Measurements by Minimum Deviation Method from Far-ultraviolet to Near Infrared

NASA Technical Reports Server (NTRS)

Leviton, Douglas B.; Madison, Timothy J.; Petrone, Peter

1998-01-01

The focal shift of an optical filter used in non-collimated light depends directly on substrate thickness and index of refraction. The HST Advanced Camera for Surveys (ACS) requires a set of filters whose focal shifts are tightly matched. Knowing the index of refraction for substrate glasses allows precise substrate thicknesses to be specified. Two refractometers have been developed at the Goddard Space Flight Center (GSFC) to determine the indices of refraction of materials from which ACS filters are made. Modem imaging detectors for the near infrared, visible, and far ultraviolet spectral regions make these simple yet sophisticated refractometers possible. A new technology, high accuracy, angular encoder also developed at GSFC makes high precision index measurement possible in the vacuum ultraviolet.

Outdoor biophotolytic system using the cyanobacterium anabaena cylindrica B629

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, G.D.; Lambert, G.R.

The cyanobacterium Anabaena cylindrica B629 was suspended in small glass beads and incubated in a gas-tight glass vessel outdoors under a gas atmosphere comprising carbon monoxide (0.2%), acetylene (5%), oxygen (6.5%), and nitrogen. The solution phase initially contained sodium bicarbonate (10mM) at pH 7. Under these conditions the organism continuously produced hydrogen gas for over three weeks. The temperature of the culture was maintained below 30 /degree/C and the minimum night temperatures were recorded. The vessel was covered by a shadecloth, which reduced the natural illumination by approximately 70%. The system is an alternative to those requiring the strict absencemore » of oxygen and little nitrogen, and requires virtually no attention during the incubation period. 18 refs.« less

Relaxation dynamics of C60

NASA Astrophysics Data System (ADS)

Walsh, Tiffany R.; Wales, David J.

1998-10-01

The relaxation dynamics of C60 from high-energy isomers to Buckminsterfullerene is examined using a master equation approach. An exhaustive catalog of the C60 fullerene isomers containing only five- and six-membered rings is combined with knowledge of the Stone-Wales rearrangements that connect all such isomers. Full geometry optimizations have been performed for all the minima and the transition states which connect them up to six Stone-Wales steps away from the global minimum. A density-functional tight-binding potential was employed to provide a quantum mechanical description of the bonding. The resulting picture of the potential energy landscape reveals a "weeping willow" structure which offers a clear explanation for the relatively long relaxation times observed experimentally. We also predict the most important transient local minima on the annealing pathway.

49 CFR 178.58 - Specification 4DA welded steel cylinders for aircraft use.

Code of Federal Regulations, 2010 CFR

2010-10-01

... stress in pounds psi; P = test pressure prescribed for water jacket test, i.e., at least 2 times service... seamless hemispheres) or a circumferentially welded cylinder (two seamless drawn shells) with a water... the wall stress at the minimum specified test pressure may not exceed 67 percent of the minimum...

49 CFR 195.306 - Test medium.

Code of Federal Regulations, 2010 CFR

2010-10-01

... which produces a hoop stress of 50 percent of specified minimum yield strength; (3) The test section is... pressure is equal to or greater than a pressure that produces a hoop stress of 50 percent of specified minimum yield strength; (3) The maximum hoop stress during the test does not exceed 80 percent of...

49 CFR 195.306 - Test medium.

Code of Federal Regulations, 2012 CFR

2012-10-01

... which produces a hoop stress of 50 percent of specified minimum yield strength; (3) The test section is... pressure is equal to or greater than a pressure that produces a hoop stress of 50 percent of specified minimum yield strength; (3) The maximum hoop stress during the test does not exceed 80 percent of...

Personality Changes as a Function of Minimum Competency Test Success or Failure.

ERIC Educational Resources Information Center

Richman, Charles L.; And Others

1987-01-01

The psychological effects of success and failure on the North Carolina Minimum Competency Test (MCT) were examined. Subjects were high school students, who were pre- and post-tested using the Rosenberg Self Esteem Scale and the High School Personality Questionnaire. Self-esteem decreased following knowledge of MCT failure. (LMO)

Minimum Competency Testing In the Dallas Independent School District.

ERIC Educational Resources Information Center

Montgomery, Patricia A.; Arrasmith, Dean G.

The development and implementation of the Dallas Independent School District's Basic Objectives Assessment Test (BOAT) are described. Beginning in 1979, this minimum competency test was administered system-wide to all students in grades 8-12 (except for those enrolled as special education students), and beginning in 1983 it will be used in…

40 CFR Table 6 to Subpart Dddd of... - Model Rule-Emission Limitations That Apply to Incinerators on and After [Date to be specified in...

Code of Federal Regulations, 2012 CFR

2012-07-01

... per million dry volume 3-run average (1 hour minimum sample time per run) Performance test (Method 10... (Reapproved 2008) c. Oxides of nitrogen 53 parts per million dry volume 3-run average (1 hour minimum sample... average (1 hour minimum sample time per run) Performance test (Method 6 or 6c at 40 CFR part 60, appendix...

40 CFR Table 6 to Subpart Dddd of... - Model Rule-Emission Limitations That Apply to Incinerators on and After [Date to be specified in...

Code of Federal Regulations, 2011 CFR

2011-07-01

... per million dry volume 3-run average (1 hour minimum sample time per run) Performance test (Method 10... (Reapproved 2008) c. Oxides of nitrogen 53 parts per million dry volume 3-run average (1 hour minimum sample... average (1 hour minimum sample time per run) Performance test (Method 6 or 6c at 40 CFR part 60, appendix...

40 CFR Table 2 to Subpart Dddd of... - Model Rule-Emission Limitations That Apply to Incinerators Before [Date to be specified in state...

Code of Federal Regulations, 2014 CFR

2014-07-01

... parts per million by dry volume 3-run average (1 hour minimum sample time per run) Performance test..., appendix A-4). Oxides of nitrogen 388 parts per million by dry volume 3-run average (1 hour minimum sample... (1 hour minimum sample time per run) Performance test (Method 6 or 6c of appendix A of this part) a...

40 CFR Table 2 to Subpart Dddd of... - Model Rule-Emission Limitations That Apply to Incinerators Before [Date to be specified in state...

Code of Federal Regulations, 2013 CFR

2013-07-01

... parts per million by dry volume 3-run average (1 hour minimum sample time per run) Performance test..., appendix A-4). Oxides of nitrogen 388 parts per million by dry volume 3-run average (1 hour minimum sample... (1 hour minimum sample time per run) Performance test (Method 6 or 6c of appendix A of this part) a...

Unraveling Reliability

ERIC Educational Resources Information Center

Popham, W. James

2009-01-01

If a person were to ask an educator to identify the two most important attributes of an education test, the response most certainly would be "validity and reliability." These two tightly wedded concepts have become icons in the field of education assessment. As far as validity is concerned, the term doesn't refer to the accuracy of a test. Rather,…

Isoflurane anesthesia results in reversible ultrastructure and occludin tight junction protein expression changes in hippocampal blood-brain barrier in aged rats.

PubMed

Cao, Yiyun; Ni, Cheng; Li, Zhengqian; Li, Lunxu; Liu, Yajie; Wang, Chunyi; Zhong, Yanfeng; Cui, Dehua; Guo, Xiangyang

2015-02-05

The underlying mechanism of isoflurane-induced cognitive dysfunction in older individuals is unknown. In this study, the effects of isoflurane exposure on the hippocampal blood-brain barrier (BBB) in aged rats were investigated because it was previously shown that BBB disruption involves in cognitive dysfunction. Twenty-month-old rats randomly received 1.5% isoflurane or vehicle gas as control. Hippocampal BBB ultrastructure was analyzed by transmission electron microscopy and expression of tight junction proteins was measured by western blot analysis. BBB permeability was detected with sodium fluorescein extravasation and further confirmed by immunoglobulin G immunohistochemistry. Spatial learning and memory were assessed by the Morris water maze test. Isoflurane anesthesia resulted in reversible time-dependent BBB ultrastructure morphological damage and significant decreases in expression of the tight junction proteins occludin, which contributed to sodium fluorescein and IgG leakage. Rats with isoflurane exposure also showed significant cognitive deficits in the Morris water maze test. This in vivo data indicate that occludin down-regulation may be one of the mediators of isoflurane-induced hippocampus BBB disruption, and may contribute to hippocampus-dependent cognitive impairment after isoflurane exposure in aged rats. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Design and fabrication of a boron reinforced intertank skirt

NASA Technical Reports Server (NTRS)

Henshaw, J.; Roy, P. A.; Pylypetz, P.

1974-01-01

Analytical and experimental studies were performed to evaluate the structural efficiency of a boron reinforced shell, where the medium of reinforcement consists of hollow aluminum extrusions infiltrated with boron epoxy. Studies were completed for the design of a one-half scale minimum weight shell using boron reinforced stringers and boron reinforced rings. Parametric and iterative studies were completed for the design of minimum weight stringers, rings, shells without rings and shells with rings. Computer studies were completed for the final evaluation of a minimum weight shell using highly buckled minimum gage skin. The detail design is described of a practical minimum weight test shell which demonstrates a weight savings of 30% as compared to an all aluminum longitudinal stiffened shell. Sub-element tests were conducted on representative segments of the compression surface at maximum stress and also on segments of the load transfer joint. A 10 foot long, 77 inch diameter shell was fabricated from the design and delivered for further testing.

Acoustic and aerodynamic testing of a scale model variable pitch fan

NASA Technical Reports Server (NTRS)

Jutras, R. R.; Kazin, S. B.

1974-01-01

A fully reversible pitch scale model fan with variable pitch rotor blades was tested to determine its aerodynamic and acoustic characteristics. The single-stage fan has a design tip speed of 1160 ft/sec (353.568 m/sec) at a bypass pressure ratio of 1.5. Three operating lines were investigated. Test results show that the blade pitch for minimum noise also resulted in the highest efficiency for all three operating lines at all thrust levels. The minimum perceived noise on a 200-ft (60.96 m) sideline was obtained with the nominal nozzle. At 44% of takeoff thrust, the PNL reduction between blade pitch and minimum noise blade pitch is 1.8 PNdB for the nominal nozzle and decreases with increasing thrust. The small nozzle (6% undersized) has the highest efficiency at all part thrust conditions for the minimum noise blade pitch setting; although, the noise is about 1.0 PNdB higher for the small nozzle at the minimum noise blade pitch position.

A Comparison of the Fit of Empirical Data to Two Latent Trait Models. Report No. 92.

ERIC Educational Resources Information Center

Hutten, Leah R.

Goodness of fit of raw test score data were compared, using two latent trait models: the Rasch model and the Birnbaum three-parameter logistic model. Data were taken from various achievement tests and the Scholastic Aptitude Test (Verbal). A minimum sample size of 1,000 was required, and the minimum test length was 40 items. Results indicated that…

Study of the low-frequency dispersion of permittivity and resistivity in tight rocks

NASA Astrophysics Data System (ADS)

Liu, Hongqi; Jie, Tian; Li, Bo; Youming, Deng; Chunning, Qiu

2017-08-01

The road to understanding the frequency dispersion (relaxation) of permittivity and resistivity in tight rocks remains relatively uncharted. Our team from Da'anzhai Group, Jurassic formation, Sichuan Basin carried out practical research to explore this phenomenon. The research was conducted under laboratory conditions for a selection of low frequencies, with ranges between 0.1 Hz to 1 kHz. Our research has shown that, although both the permittivity and resistivity decrease as the frequency increases, the two individual metrics display different behaviours when compared with each other. While the degree of resistivity variation is minimal, to the point that it is redundant, the permittivity, on the other hand, demonstrates something that is scientifically noteworthy. Permittivity has a distinctive dispersion degree across the entire sample of frequencies and the difference between the minimum and maximum frequencies is several orders of magnitude. An additional, and unexpected, learning from our research is that the level of frequency dispersion increases as the water saturation and concentration increases. In this paper, a collection of equations has been formulated to describe this relationship. These equations particularly shed light on the areas of rock porosity and saturation. They also show that the degree of frequency dispersion of permittivity or resistivity can be used as a function of water saturation and concentration. Two new variables are introduced here, DR and DC, to demonstrate the relaxation law quantitatively. In our practical research, we have characterised the relationship between the saturation and concentration with dielectric relaxation, using three different concentrations of DR and DC and five different saturations of NaCl solution. In difference to conventional Archie's multiple experimental parameters, we have established a new formula to derive the saturation from Rp and Cp, or from DR and DC directly. Two important frequencies were also further investigated for Cp dispersion: first is the critical frequency, which marks the dispersion speed change from steep phase to steady phase, and second is the zero-frequency, which marks the dispersion when it approaches zero. All tight rocks were measured under the same conditions, with the results displaying the same pattern of variations. The results have led us to believe that Cp's frequency dispersion at low-frequencies provides a new methodology to characterise tight rocks.

Modified Hydra Bioassay to Evaluate the Toxicity of Multiple Mycotoxins and Predict the Detoxification Efficacy of a Clay-Based Sorbent

PubMed Central

Brown, KA; Mays, T; Romoser, A; Marroquin-Cardona, A; Mitchell, NJ; Elmore, SE; Phillips, TD

2013-01-01

Food shortages and lack of food supply regulation in developing countries often leads to chronic exposure of vulnerable populations to hazardous mixtures of mycotoxins, including aflatoxin B1 (AFB1) and fumonisin B1 (FB1). A refined calcium montmorillonite clay (i.e. UPSN) has been reported to tightly bind these toxins, thereby decreasing bioavailability in humans and animals. Hence, our objectives in the present work were to examine the ability of UPSN to bind mixtures of AFB1 and FB1at gastrointestinally relevant pH in vitro, and to utilize a rapid in vivo bioassay to evaluate AFB1 and FB1 toxicity and UPSN efficacy. Isothermal sorption data indicated tight AFB1 binding to UPSN surfaces at both pH 2.0 and 6.5, but substantially more FB1 bound at pH 2.0 than 6.5. Site-specific competition occurred between the toxins when exposed to UPSN in combination. Importantly, treatment with UPSN resulted in significant protection to mycotoxin-exposed hydra maintained at pH 6.9-7.0. Hydra were exposed to FB1, AFB1 and FB1/AFB1 combinations with and without UPSN. Toxic response over 92 hours was rated based on morphology and mortality. Hydra assay results indicated a minimum effective concentration (MEC) of 20 μg/mLfor AFB1, while the MEC for FB1 was not reached. The MEC for co-exposure was 400 μg/mL FB1 + 10 μg/mL AFB1. This study demonstrates that UPSN sorbs both mycotoxins tightly at physiologically relevant pH levels, resulting in decreased bioavailability, and that a modified hydra bioassay can be used as an initial screen in vivo to predict efficacy of toxin binding agents. PMID:23047854

Modified hydra bioassay to evaluate the toxicity of multiple mycotoxins and predict the detoxification efficacy of a clay-based sorbent.

PubMed

Brown, K A; Mays, T; Romoser, A; Marroquin-Cardona, A; Mitchell, N J; Elmore, S E; Phillips, T D

2014-01-01

Food shortages and a lack of food supply regulation in developing countries often leads to chronic exposure of vulnerable populations to hazardous mixtures of mycotoxins, including aflatoxin B(1) (AFB(1)) and fumonisin B(1) (FB(1)). A refined calcium montmorillonite clay [i.e. uniform particle size NovaSil (UPSN)] has been reported to tightly bind these toxins, thereby decreasing bioavailability in humans and animals. Hence, our objectives in the present study were to examine the ability of UPSN to bind mixtures of AFB(1) and FB(1) at gastrointestinally relevant pH in vitro, and to utilize a rapid in vivo bioassay to evaluate AFB(1) and FB(1) toxicity and UPSN efficacy. Isothermal sorption data indicated tight AFB(1) binding to UPSN surfaces at both pH 2.0 and 6.5, but substantially more FB(1) bound at pH 2.0 than 6.5. Site-specific competition occurred between the toxins when exposed to UPSN in combination. Importantly, treatment with UPSN resulted in significant protection to mycotoxin-exposed hydra maintained at pH 6.9-7.0. Hydra were exposed to FB(1), AFB(1) and FB(1) /AFB(1) combinations with and without UPSN. A toxic response over 92 h was rated based on morphology and mortality. Hydra assay results indicated a minimum effective concentration (MEC) of 20 µg ml(-1) for AFB(1), whereas the MEC for FB(1) was not reached. The MEC for co-exposure was 400 µg ml(-1) FB(1) + 10 µg ml(-1) AFB(1). This study demonstrates that UPSN sorbs both mycotoxins tightly at physiologically relevant pH levels, resulting in decreased bioavailability, and that a modified hydra bioassay can be used as an initial screen in vivo to predict efficacy of toxin-binding agents. Copyright © 2012 John Wiley & Sons, Ltd.

49 CFR Appendix B to Part 179 - Procedures for Simulated Pool and Torch-Fire Testing

Code of Federal Regulations, 2013 CFR

2013-10-01

... thermal response of the plate. (3) Before exposure to the pool-fire simulation, none of the thermocouples... exposed to the simulated pool fire. (5) A pool-fire simulation test must run for a minimum of 100 minutes...) A minimum of three consecutive successful simulation fire tests must be performed for each thermal...

49 CFR Appendix B to Part 179 - Procedures for Simulated Pool and Torch-Fire Testing

Code of Federal Regulations, 2014 CFR

2014-10-01

... thermal response of the plate. (3) Before exposure to the pool-fire simulation, none of the thermocouples... exposed to the simulated pool fire. (5) A pool-fire simulation test must run for a minimum of 100 minutes...) A minimum of three consecutive successful simulation fire tests must be performed for each thermal...

49 CFR 178.58 - Specification 4DA welded steel cylinders for aircraft use.

Code of Federal Regulations, 2011 CFR

2011-10-01

... stress in pounds psi; P = test pressure prescribed for water jacket test, i.e., at least 2 times service... hemispheres) or a circumferentially welded cylinder (two seamless drawn shells) with a water capacity not over... the wall stress at the minimum specified test pressure may not exceed 67 percent of the minimum...

Development and Testing of a ``Backlash-Free'' Gas-Tight High Precision Sample Handling Mechanism for Combined Science on the ExoMars 2018 Rover

NASA Astrophysics Data System (ADS)

Paul, R.; Redlich, D.; Richter, L.; Zuknik, K.-H.; Muhlbauer, Q.; Thiel, M.; Fowler, L.; Tattusch, T.; Weisz, H.; Musso, F.; Durrant, S.

2015-09-01

This paper presents the development and testing by the OHB System AG of the Powdered Sample Handling Mechanism (PSHS) that is part of the rover of the European Space Agency 2018 ExoMars Mission, a cooperative mission with Roscosmos including a scientific instrument contribution from NASA. The task of this mechanism is to flatten and position powdered Martian soil samples allowing subsequent investigation of selected grains by different optical instruments thus providing combined science in an ultra-clean environment.The exceptional sensitivity of these instruments causes extremely challenging requirements with respect to positioning performance as well as cleanliness and contamination control. The impact of these design drivers is highlighted focusing on specific mechanism features such as the pre-torque device to minimize the backlash and the dynamic feed-through, allowing a gas-tight encapsulation of an ultra-clean zone free of drive-train components.Subsequently the results of the test campaign of an elegant breadboard under Mars-like conditions, as well as first QM test results are described. Furthermore the outcomes of combined tests with an optical instrument are reported.

Facial and ocular deposition of nebulized budesonide: effects of face mask design.

PubMed

Harris, Keith W; Smaldone, Gerald C

2008-02-01

In vivo case reports and in vitro studies have indicated that aerosol therapy using face masks can result in drug deposition on the face and in the eyes, and that face mask design may affect drug delivery. To test different mask/nebulizer combinations for budesonide, a nebulized steroid used to treat pediatric patients with asthma. Using high-performance liquid chromatography, drug delivery (inhaled mass), facial, and ocular deposition of budesonide aerosols were studied in vitro using a ventilated face facsimile (tidal volume, 50 mL; rate, 25 breaths/min, duty cycle 0.4), a tight-fitting test mask, a standard commercial mask, and a prototype mask designed to optimize delivery by reducing particle inertia. Nebulizer insertion into the mask (front loaded vs bottom loaded) was also tested. Particle size was measured by cascade impaction. Pari LC Plus (PARI Respiratory Equipment; Midlothian, VA) and MistyNeb (Allegiance; McGaw Park, IL) nebulizers were tested. Inhaled mass for tight-fitting and prototype masks was similar (13.2 +/- 1.85% vs 14.4 +/- 0.67% [percentage of nebulizer charge], p = 0.58) and significantly greater than for the commercial mask (3.03 +/- 0.26%, p = 0.005). Mask insertion of nebulizer was a key factor (inhaled mass: front loaded vs bottom loaded, 8.23 +/- 0.18% vs 3.03 +/- 0.26%; p = 0.005). Ocular deposition varied by an order of magnitude and was a strong function of mask design (4.77 +/- 0.24% vs 0.35 +/- 0.05%, p = 0.002, tight fitting vs prototype). Particle sizes (7.3 to 9 microm) were larger than previously reported for budesonide. For pediatric breathing patterns, mask design is a key factor defining budesonide delivery to the lungs, face, and eyes. Front-loaded nebulizer mask combinations are more efficient than bottom-loaded systems.

Studying the varied shapes of gold clusters by an elegant optimization algorithm that hybridizes the density functional tight-binding theory and the density functional theory

NASA Astrophysics Data System (ADS)

Yen, Tsung-Wen; Lim, Thong-Leng; Yoon, Tiem-Leong; Lai, S. K.

2017-11-01

We combined a new parametrized density functional tight-binding (DFTB) theory (Fihey et al. 2015) with an unbiased modified basin hopping (MBH) optimization algorithm (Yen and Lai 2015) and applied it to calculate the lowest energy structures of Au clusters. From the calculated topologies and their conformational changes, we find that this DFTB/MBH method is a necessary procedure for a systematic study of the structural development of Au clusters but is somewhat insufficient for a quantitative study. As a result, we propose an extended hybridized algorithm. This improved algorithm proceeds in two steps. In the first step, the DFTB theory is employed to calculate the total energy of the cluster and this step (through running DFTB/MBH optimization for given Monte-Carlo steps) is meant to efficiently bring the Au cluster near to the region of the lowest energy minimum since the cluster as a whole has explicitly considered the interactions of valence electrons with ions, albeit semi-quantitatively. Then, in the second succeeding step, the energy-minimum searching process will continue with a skilledly replacement of the energy function calculated by the DFTB theory in the first step by one calculated in the full density functional theory (DFT). In these subsequent calculations, we couple the DFT energy also with the MBH strategy and proceed with the DFT/MBH optimization until the lowest energy value is found. We checked that this extended hybridized algorithm successfully predicts the twisted pyramidal structure for the Au40 cluster and correctly confirms also the linear shape of C8 which our previous DFTB/MBH method failed to do so. Perhaps more remarkable is the topological growth of Aun: it changes from a planar (n =3-11) → an oblate-like cage (n =12-15) → a hollow-shape cage (n =16-18) and finally a pyramidal-like cage (n =19, 20). These varied forms of the cluster's shapes are consistent with those reported in the literature.

Stage-dependent analgesia of electro-acupuncture in a mouse model of cutaneous cancer pain.

PubMed

Mao-Ying, Qi-Liang; Cui, Ke-Mi; Liu, Qiong; Dong, Zhi-Qiang; Wang, Wei; Wang, Jun; Sha, Hong; Wu, Gen-Cheng; Wang, Yan-Qing

2006-11-01

Acupuncture is one of the most effective alternative medical treatments in pain management with the advantages of simple application, low cost and minimal side effects. However its scientific evidence and laws of action are not very clear in cancer pain relieving. The aim of this study was to examine the immediate and therapeutic anti-hyperalgesic effect of electro-acupuncture (EA) on a mouse model of cutaneous cancer pain. B16-BL6 melanoma cells were inoculated into the plantar region of unilateral hind paw and the thermal hyperalgesia was measured by using radiant heat test and hot plate test. C57BL/6 mice showed moderate and marked hyperalgesia during days 8-12 and from day 14 after the orthotopic inoculation of B16-BL6 melanoma cells into the hind paw. Single EA on day 8 after inoculation showed significant analgesic effect immediately after the treatment, the analgesic effect reached its maximum within 15-30min and declined to its minimum at 50min after EA treatment. Single EA treatment on day 20 showed no significant analgesic effect; Repeated EA treatments (started from day 8, once every other day) showed therapeutic analgesic effect, while it showed no therapeutic effect when started from day 16, a relatively late stage of this cancer pain model. The results demonstrated that EA had anti-hyperalgesic effect on early stage of cutaneous cancer pain but not on late stage. These results indicated a tight correlation of EA anti-hyperalgesic effects with the time window of cancer pain.

A Randomised, Placebo-Controlled Trial of Neurodynamic Sliders on Hamstring Responses in Footballers with Hamstring Tightness

PubMed Central

Areeudomwong, Pattanasin; Oatyimprai, Ketsarakon; Pathumb, Saranchana

2016-01-01

Background Neurodynamics intervention is known to increase apparent muscle extensibility, but information regarding hamstring responses after a neurodynamic sliders (NS) technique is scarce. The aim of this study was to evaluate the effects of NS on apparent hamstring extensibility and activity in footballers with hamstring tightness. Methods Forty eligible healthy male footballers with hamstring tightness were each randomly allocated to either a 4-week NS technique or a control group (CG) receiving placebo shortwave intervention. Knee extension angles were measured with the passive knee extension test, and maximal voluntary isometric contraction (MVIC) of hamstrings was measured by a surface electromyography at baseline and after intervention sessions. Results The results showed that NS produced a statistically and clinically significant increase in knee extension angle compared to CG (P < 0.001); however, there was no difference between the groups receiving MVIC of hamstrings. Within group comparison, NS also provided a significant increase in knee extension angle (P < 0.001), whereas the control group did not. There was no change in hamstring MVIC in either group after intervention. Conclusions The findings of this study reveal that four weeks of NS technique improved apparent hamstring extensibility but did not change the hamstring activity in footballers with hamstring tightness. PMID:28090180

A Simplified Baseband Prefilter Model with Adaptive Kalman Filter for Ultra-Tight COMPASS/INS Integration

PubMed Central

Luo, Yong; Wu, Wenqi; Babu, Ravindra; Tang, Kanghua; Luo, Bing

2012-01-01

COMPASS is an indigenously developed Chinese global navigation satellite system and will share many features in common with GPS (Global Positioning System). Since the ultra-tight GPS/INS (Inertial Navigation System) integration shows its advantage over independent GPS receivers in many scenarios, the federated ultra-tight COMPASS/INS integration has been investigated in this paper, particularly, by proposing a simplified prefilter model. Compared with a traditional prefilter model, the state space of this simplified system contains only carrier phase, carrier frequency and carrier frequency rate tracking errors. A two-quadrant arctangent discriminator output is used as a measurement. Since the code tracking error related parameters were excluded from the state space of traditional prefilter models, the code/carrier divergence would destroy the carrier tracking process, and therefore an adaptive Kalman filter algorithm tuning process noise covariance matrix based on state correction sequence was incorporated to compensate for the divergence. The federated ultra-tight COMPASS/INS integration was implemented with a hardware COMPASS intermediate frequency (IF), and INS's accelerometers and gyroscopes signal sampling system. Field and simulation test results showed almost similar tracking and navigation performances for both the traditional prefilter model and the proposed system; however, the latter largely decreased the computational load. PMID:23012564

Geology of tight oil and potential tight oil reservoirs in the lower part of the Green River Formation, Uinta, Piceance, and Greater Green River Basins, Utah, Colorado, and Wyoming

USGS Publications Warehouse

Johnson, Ronald C.; Birdwell, Justin E.; Mercier, Tracey J.; Brownfield, Michael E.

2016-05-02

The recent successful development of a tight oil play in the Eocene-age informal Uteland Butte member of the lacustrine Green River Formation in the Uinta Basin, Utah, using modern horizontal drilling and hydraulic fracturing techniques has spurred a renewed interest in the tight oil potential of lacustrine rocks. The Green River Formation was deposited by two large lakes, Lake Uinta in the Uinta and Piceance Basins and Lake Gosiute in the Greater Green River Basin. These three basins contain the world’s largest in-place oil shale resources with recent estimates of 1.53 trillion, 1.33 trillion, and 1.44 trillion barrels of oil in place in the Piceance, Uinta, and Greater Green River Basins, respectively. The Uteland Butte member was deposited during an early freshwater stage of the lake in the Uinta Basin prior to deposition of the assessed oil shale intervals. This report only presents information on the early freshwater interval and overlying brackish-water interval in all three basins because these intervals are most likely to have tight oil potential. Burial histories of the three basins were reconstructed to study (1) variations in subsidence and lake development, and (2) post deposition burial that led to the development of a petroleum system in only the Uinta Basin. The Uteland Butte member is a successful tight oil play because it is thermally mature for hydrocarbon generation and contains organic-rich shale, brittle carbonate, and porous dolomite. Abnormally high pressure in parts of the Uteland Butte is also important to production. Variations in organic richness of the Uteland Butte were studied using Fischer assay analysis from oil shale assessments, and pressures were studied using drill-stem tests. Freshwater lacustrine intervals in the Piceance and Greater Green River Basins are immature for hydrocarbon generation and contain much less carbonate than the Uteland Butte member. The brackish-water interval in the Uinta Basin is thermally mature for hydrocarbon generation but is clay-rich and contains little carbonate, and thus is a poor prospect for tight oil development.

Characterization of Gas Transport Properties of Fractured Rocks By Borehole and Chamber Tests.

NASA Astrophysics Data System (ADS)

Shimo, M.; Shimaya, S.; Maejima, T.

2014-12-01

Gas transport characteristics of fractured rocks is a great concern to variety of engineering applications such as underground storage of LPG, nuclear waste disposal, CCS and gas flooding in the oil field. Besides absolute permeability, relative permeability and capillary pressure as a function of water saturation have direct influences to the results of two phase flow simulation. However, number of the reported gas flow tests for fractured rocks are limited, therefore, the applicability of the conventional two-phase flow functions used for porous media, such as Mualem-van Genuchten model, to prediction of the gas transport in the fractured rock mass are not well understood. The authors conducted the two types of in-situ tests, with different scales, a borehole gas-injection test and a chamber gas-injection test in fractured granitic rock. These tests were conducted in the Cretaceous granitic rocks at the Namikata underground LPG storage cavern construction site in Ehime Prefecture in Japan, preceding to the cavern scale gas-tightness test. A borehole injection test was conducted using vertical and sub-vertical boreholes drilled from the water injection tunnel nearly at the depth of the top of the cavern, EL-150m. A new type downhole gas injection equipment that is capable to create a small 'cavern' within a borehole was developed. After performing a series of preliminary tests to investigate the hydraulic conductivity and gas-tightness, i.e. threshold pressure, gas injection tests were conducted under different gas pressure. Fig.1 shows an example of the test results From a chamber test using a air pressurizing chamber with volume of approximately166m3, the gas-tightness was confirmed within the uncertainty of 22Pa under the storage pressure of 0.7MPa, however, significant air leakage occurred possibly through an open fracture intersecting the chamber just after cavern pressure exceeds the initial hydrostatic pressure at the ceiling level of the chamber. Anomalies were detected in the data of the pore pressure as well as AE monitoring around the chamber. Results from the above two tests were simulated using a multi-phase transport simulator, TOUGH2, developed at Lawrence Berkeley National Laboratory. Fig.2 shows the model and an example of the simulation.

Efficient self-consistency for magnetic tight binding

NASA Astrophysics Data System (ADS)

Soin, Preetma; Horsfield, A. P.; Nguyen-Manh, D.

2011-06-01

Tight binding can be extended to magnetic systems by including an exchange interaction on an atomic site that favours net spin polarisation. We have used a published model, extended to include long-ranged Coulomb interactions, to study defects in iron. We have found that achieving self-consistency using conventional techniques was either unstable or very slow. By formulating the problem of achieving charge and spin self-consistency as a search for stationary points of a Harris-Foulkes functional, extended to include spin, we have derived a much more efficient scheme based on a Newton-Raphson procedure. We demonstrate the capabilities of our method by looking at vacancies and self-interstitials in iron. Self-consistency can indeed be achieved in a more efficient and stable manner, but care needs to be taken to manage this. The algorithm is implemented in the code PLATO. Program summaryProgram title:PLATO Catalogue identifier: AEFC_v2_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEFC_v2_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 228 747 No. of bytes in distributed program, including test data, etc.: 1 880 369 Distribution format: tar.gz Programming language: C and PERL Computer: Apple Macintosh, PC, Unix machines Operating system: Unix, Linux, Mac OS X, Windows XP Has the code been vectorised or parallelised?: Yes. Up to 256 processors tested RAM: Up to 2 Gbytes per processor Classification: 7.3 External routines: LAPACK, BLAS and optionally ScaLAPACK, BLACS, PBLAS, FFTW Catalogue identifier of previous version: AEFC_v1_0 Journal reference of previous version: Comput. Phys. Comm. 180 (2009) 2616 Does the new version supersede the previous version?: Yes Nature of problem: Achieving charge and spin self-consistency in magnetic tight binding can be very difficult. Our existing schemes failed altogether, or were very slow. Solution method: A new scheme for achieving self-consistency in orthogonal tight binding has been introduced that explicitly evaluates the first and second derivatives of the energy with respect to input charge and spin, and then uses these to search for stationary values of the energy. Reasons for new version: Bug fixes and new functionality. Summary of revisions: New charge and spin mixing scheme for orthogonal tight binding. Numerous small bug fixes. Restrictions: The new mixing scheme scales poorly with system size. In particular the memory usage scales as number of atoms to the power 4. It is restricted to systems with about 200 atoms or less. Running time: Test cases will run in a few minutes, large calculations may run for several days.

49 CFR 572.200 - Instrumentation and test conditions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... mass moment of inertia of 3646 kg-cm2. (b) The test probe for the lateral abdomen impact test is the... a minimum mass moment of inertia of 3646 kg-cm2. (c) The test probe for the pelvis-iliac impact... surface 50.8 × 88.9 mm for a depth of at least 76 mm and a minimum mass moment of inertia of 5000 kg-cm2...

49 CFR 572.200 - Instrumentation and test conditions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... mass moment of inertia of 3646 kg-cm2. (b) The test probe for the lateral abdomen impact test is the... a minimum mass moment of inertia of 3646 kg-cm2. (c) The test probe for the pelvis-iliac impact... surface 50.8 × 88.9 mm for a depth of at least 76 mm and a minimum mass moment of inertia of 5000 kg-cm2...

49 CFR 572.200 - Instrumentation and test conditions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... mass moment of inertia of 3646 kg-cm2. (b) The test probe for the lateral abdomen impact test is the... a minimum mass moment of inertia of 3646 kg-cm2. (c) The test probe for the pelvis-iliac impact... surface 50.8 × 88.9 mm for a depth of at least 76 mm and a minimum mass moment of inertia of 5000 kg-cm2...

Comparison and verification of two models which predict minimum principal in situ stress from triaxial data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harikrishnan, R.; Hareland, G.; Warpinski, N.R.

This paper evaluates the correlation between values of minimum principal in situ stress derived from two different models which use data obtained from triaxial core tests and coefficient for earth at rest correlations. Both models use triaxial laboratory tests with different confining pressures. The first method uses a vcrified fit to the Mohr failure envelope as a function of average rock grain size, which was obtained from detailed microscopic analyses. The second method uses the Mohr-Coulomb failure criterion. Both approaches give an angle in internal friction which is used to calculate the coefficient for earth at rest which gives themore » minimum principal in situ stress. The minimum principal in situ stress is then compared to actual field mini-frac test data which accurately determine the minimum principal in situ stress and are used to verify the accuracy of the correlations. The cores and the mini-frac stress test were obtained from two wells, the Gas Research Institute`s (GRIs) Staged Field Experiment (SFE) no. 1 well through the Travis Peak Formation in the East Texas Basin, and the Department of Energy`s (DOE`s) Multiwell Experiment (MWX) wells located west-southwest of the town of Rifle, Colorado, near the Rulison gas field. Results from this study indicates that the calculated minimum principal in situ stress values obtained by utilizing the rock failure envelope as a function of average rock grain size correlation are in better agreement with the measured stress values (from mini-frac tests) than those obtained utilizing Mohr-Coulomb failure criterion.« less

49 CFR 178.50 - Specification 4B welded or brazed steel cylinders.

Code of Federal Regulations, 2011 CFR

2011-10-01

...)] / (D2 − d2) Where: S = wall stress in psi; P = minimum test pressure prescribed for water jacket test or... seams that are forged lap-welded or brazed and with water capacity (nominal) not over 1,000 pounds and a... calculated wall stress at minimum test pressure (paragraph (i)(4) of this section) may not exceed the...

49 CFR 178.50 - Specification 4B welded or brazed steel cylinders.

Code of Federal Regulations, 2010 CFR

2010-10-01

...)] / (D2 − d2) Where: S = wall stress in psi; P = minimum test pressure prescribed for water jacket test or... longitudinal seams that are forged lap-welded or brazed and with water capacity (nominal) not over 1,000 pounds... calculated wall stress at minimum test pressure (paragraph (i)(4) of this section) may not exceed the...

Onset of mortality increase with age and age trajectories of mortality from all diseases in the four Nordic countries.

PubMed

Dolejs, Josef; Marešová, Petra

2017-01-01

The answer to the question "At what age does aging begin?" is tightly related to the question "Where is the onset of mortality increase with age?" Age affects mortality rates from all diseases differently than it affects mortality rates from nonbiological causes. Mortality increase with age in adult populations has been modeled by many authors, and little attention has been given to mortality decrease with age after birth. Nonbiological causes are excluded, and the category "all diseases" is studied. It is analyzed in Denmark, Finland, Norway, and Sweden during the period 1994-2011, and all possible models are screened. Age trajectories of mortality are analyzed separately: before the age category where mortality reaches its minimal value and after the age category. Resulting age trajectories from all diseases showed a strong minimum, which was hidden in total mortality. The inverse proportion between mortality and age fitted in 54 of 58 cases before mortality minimum. The Gompertz model with two parameters fitted as mortality increased with age in 17 of 58 cases after mortality minimum, and the Gompertz model with a small positive quadratic term fitted data in the remaining 41 cases. The mean age where mortality reached minimal value was 8 (95% confidence interval 7.05-8.95) years. The figures depict an age where the human population has a minimal risk of death from biological causes. Inverse proportion and the Gompertz model fitted data on both sides of the mortality minimum, and three parameters determined the shape of the age-mortality trajectory. Life expectancy should be determined by the two standard Gompertz parameters and also by the single parameter in the model c/x. All-disease mortality represents an alternative tool to study the impact of age. All results are based on published data.

Discrete Fluctuations in Memory Erasure without Energy Cost

NASA Astrophysics Data System (ADS)

Croucher, Toshio; Bedkihal, Salil; Vaccaro, Joan A.

2017-02-01

According to Landauer's principle, erasing one bit of information incurs a minimum energy cost. Recently, Vaccaro and Barnett (VB) explored information erasure within the context of generalized Gibbs ensembles and demonstrated that for energy-degenerate spin reservoirs the cost of erasure can be solely in terms of a minimum amount of spin angular momentum and no energy. As opposed to the Landauer case, the cost of erasure in this case is associated with an intrinsically discrete degree of freedom. Here we study the discrete fluctuations in this cost and the probability of violation of the VB bound. We also obtain a Jarzynski-like equality for the VB erasure protocol. We find that the fluctuations below the VB bound are exponentially suppressed at a far greater rate and more tightly than for an equivalent Jarzynski expression for VB erasure. We expose a trade-off between the size of the fluctuations and the cost of erasure. We find that the discrete nature of the fluctuations is pronounced in the regime where reservoir spins are maximally polarized. We also state the first laws of thermodynamics corresponding to the conservation of spin angular momentum for this particular erasure protocol. Our work will be important for novel heat engines based on information erasure schemes that do not incur an energy cost.

Instability of superfluid Fermi gases induced by a rotonlike density mode in optical lattices

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yunomae, Yoshihiro; Yamamoto, Daisuke; Danshita, Ippei

2009-12-15

We study the stability of superfluid Fermi gases in deep optical lattices in the BCS-Bose-Einstein condensation (BEC) crossover at zero temperature. Within the tight-binding attractive Hubbard model, we calculate the spectrum of the low-energy Anderson-Bogoliubov (AB) mode as well as the single-particle excitations in the presence of superfluid flow in order to determine the critical velocities. To obtain the spectrum of the AB mode, we calculate the density response function in the generalized random-phase approximation applying the Green's function formalism developed by Cote and Griffin to the Hubbard model. We find that the spectrum of the AB mode is separatedmore » from the particle-hole continuum having the characteristic rotonlike minimum at short wavelength due to the strong charge-density-wave fluctuations. The energy of the rotonlike minimum decreases with increasing the lattice velocity and it reaches zero at the critical velocity which is smaller than the pair-breaking velocity. This indicates that the superfluid state is energetically unstable due to the spontaneous emission of the short-wavelength rotonlike excitations of the AB mode instead due to pair breaking. We determine the critical velocities as functions of the interaction strength across the BCS-BEC crossover regime.« less

Tunneling magnetoresistance sensor with pT level 1/f magnetic noise

NASA Astrophysics Data System (ADS)

Deak, James G.; Zhou, Zhimin; Shen, Weifeng

2017-05-01

Magnetoresistive devices are important components in a large number of commercial electronic products in a wide range of applications including industrial position sensors, automotive sensors, hard disk read heads, cell phone compasses, and solid state memories. These devices are commonly based on anisotropic magnetoresistance (AMR) and giant magnetoresistance (GMR), but over the past few years tunneling magnetoresistance (TMR) has been emerging in more applications. Here we focus on recent work that has enabled the development of TMR magnetic field sensors with 1/f noise of less than 100 pT/rtHz at 1 Hz. Of the commercially available sensors, the lowest noise devices have typically been AMR, but they generally have the largest die size. Based on this observation and modeling of experimental data size and geometry dependence, we find that there is an optimal design rule that produces minimum 1/f noise. This design rule requires maximizing the areal coverage of an on-chip flux concentrator, providing it with a minimum possible total gap width, and tightly packing the gaps with MTJ elements, which increases the effective volume and decreases the saturation field of the MTJ freelayers. When properly optimized using this rule, these sensors have noise below 60 pT/rtHz, and could possibly replace fluxgate magnetometers in some applications.

Potential of mean force for ion pairs in non-aqueous solvents. Comparison of polarizable and non-polarizable MD simulations

NASA Astrophysics Data System (ADS)

Odinokov, A. V.; Leontyev, I. V.; Basilevsky, M. V.; Petrov, N. Ch.

2011-01-01

Potentials of mean force (PMF) are calculated for two model ion pairs in two non-aqueous solvents. Standard non-polarizable molecular dynamics simulation (NPMD) and approximate polarizable simulation (PMD) are implemented and compared as tools for monitoring PMF profiles. For the polar solvent (dimethylsulfoxide, DMSO) the PMF generated in terms of the NPMD reproduces fairly well the refined PMD-PMF profile. For the non-polar solvent (benzene) the conventional NPMD computation proves to be deficient. The validity of the correction found in terms of the approximate PMD approach is verified by its comparison with the result of the explicit PMD computation in benzene. The shapes of the PMF profiles in DMSO and in benzene are quite different. In DMSO, owing to dielectric screening, the PMF presents a flat plot with a shallow minimum positioned in the vicinity of the van der Waals contact of the ion pair. For the benzene case, the observed minimum proves to be unexpectedly deep, which manifests the formation of a tightly-binded contact ion pair. This remarkable effect arises owing to the strong electrostatic interaction that is incompletely screened by a non-polar medium. The PMFs for the binary benzene/DMSO mixtures display intermediate behaviour depending on the DMSO content.

Preliminary SP-100/Stirling Heat Exchanger Designs

NASA Astrophysics Data System (ADS)

Schmitz, Paul; Tower, Leonard; Dawson, Ronald; Blue, Brain; Dunn, Pat

1994-07-01

Analytic modeling of several heat exchanger concepts to couple the SP-100 nuclear reactor primary lithium loop and the Space Stirling Power Convertor(SSPC)was performed. Four 25 kWe SSPC's are used to produce the required 100 kW of electrical power. This design work focused on the interface between a single SSPC and the primary lithium loop. Manifolding to separate and collect the four channel flow was not modeled. This work modeled two separate types of heat exchanger interfaces (conductive coupling and radiative coupling) to explore their relative advantages and disadvantages. The minimum mass design of the conductively coupled concepts was 18 kg or 0.73 kg/kWe for a single 25 kWe convertor. The minimum mass radiatively coupled concept was 41 kg or 1.64 kg/kWe. The direct conduction heat exchanger provides a lighter weight system because of its ability to operate the Stirling convertor evaporator at higher heat fluxes than those attainable by the radiatively coupled systems. Additionally the conductively coupled concepts had relatively small volumes and provide potentially simpler assembly. Their disadvantages were the tight tolerances and material joining problems associated with this refractory to superalloy interface. The advantages of the radiatively coupled designs were the minimal material interface problems.

Preliminary SP-100/Stirling heat exchanger designs

NASA Astrophysics Data System (ADS)

Schmitz, Paul; Tower, Leonard; Dawson, Ronald; Blue, Brian; Dunn, Pat

1993-12-01

Analytic modeling of several heat exchanger concepts to couple the SP-100 nuclear reactor primary lithium loop and the Space Stirling Power Convertor (SSPC) was performed. Four 25 kWe SSPC's are used to produce the required 100 kW of electrical power. This design work focused on the interface between a single SSPC and the primary lithium loop. Manifolding to separate and collect the four channel flow was not modeled. This work modeled two separate types of heat exchanger interfaces (conductive coupling and radiative coupling) to explore their relative advantages and disadvantages. The minimum mass design of the conductively coupled concepts was 18 kg or 0.73 kg/kWe for a single 25 kWe convertor. The minimum mass radiatively coupled concept was 41 kg or 1.64 kg/kWe. The direct conduction heat exchanger provides a lighter weight system because of its ability to operate the Stirling convertor evaporator at higher heat fluxes than those attainable by the radiatively coupled systems. Additionally the conductively coupled concepts had relatively small volumes and provide potentially simpler assembly. Their disadvantages were the tight tolerances and material joining problems associated with this refractory to superalloy interface. The advantages of the radiatively coupled designs were the minimal material interface problems.

Preliminary SP-100/Stirling heat exchanger designs

NASA Technical Reports Server (NTRS)

Schmitz, Paul; Tower, Leonard; Dawson, Ronald; Blue, Brian; Dunn, Pat

1993-01-01

Analytic modeling of several heat exchanger concepts to couple the SP-100 nuclear reactor primary lithium loop and the Space Stirling Power Convertor (SSPC) was performed. Four 25 kWe SSPC's are used to produce the required 100 kW of electrical power. This design work focused on the interface between a single SSPC and the primary lithium loop. Manifolding to separate and collect the four channel flow was not modeled. This work modeled two separate types of heat exchanger interfaces (conductive coupling and radiative coupling) to explore their relative advantages and disadvantages. The minimum mass design of the conductively coupled concepts was 18 kg or 0.73 kg/kWe for a single 25 kWe convertor. The minimum mass radiatively coupled concept was 41 kg or 1.64 kg/kWe. The direct conduction heat exchanger provides a lighter weight system because of its ability to operate the Stirling convertor evaporator at higher heat fluxes than those attainable by the radiatively coupled systems. Additionally the conductively coupled concepts had relatively small volumes and provide potentially simpler assembly. Their disadvantages were the tight tolerances and material joining problems associated with this refractory to superalloy interface. The advantages of the radiatively coupled designs were the minimal material interface problems.

40 CFR 600.010-08 - Vehicle test requirements and minimum data requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... data requirements. 600.010-08 Section 600.010-08 Protection of Environment ENVIRONMENTAL PROTECTION... requirements and minimum data requirements. (a) Unless otherwise exempted from specific emission compliance... applicable): (1) The manufacturer shall generate FTP fuel economy data by testing according to the applicable...

Minimum Competency Testing (MCT). Some Remarks.

ERIC Educational Resources Information Center

Howell, John F.

The effort to institute minimum competency testing (MCT) is nearly universal despite the need to debate its basic definitions, implications, and consequences beforehand. There are seven distinct reasons for the MCT movement: (1) legislative zeal; (2) unfavorable allegations by local and national press; (3) economic accountability; (4) the…

42 CFR 84.124 - Facepiece tests; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Facepiece tests; minimum requirements. 84.124 Section 84.124 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Gas Masks...

42 CFR 84.124 - Facepiece tests; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Facepiece tests; minimum requirements. 84.124 Section 84.124 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Gas Masks...

42 CFR 84.124 - Facepiece tests; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Facepiece tests; minimum requirements. 84.124 Section 84.124 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Gas Masks...

42 CFR 84.124 - Facepiece tests; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Facepiece tests; minimum requirements. 84.124 Section 84.124 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Gas Masks...

42 CFR 84.124 - Facepiece tests; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Facepiece tests; minimum requirements. 84.124 Section 84.124 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Gas Masks...

40 CFR 600.010 - Vehicle test requirements and minimum data requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Vehicle test requirements and minimum data requirements. 600.010 Section 600.010 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES General...

40 CFR 600.010 - Vehicle test requirements and minimum data requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Vehicle test requirements and minimum data requirements. 600.010 Section 600.010 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES General...

40 CFR 600.010 - Vehicle test requirements and minimum data requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Vehicle test requirements and minimum data requirements. 600.010 Section 600.010 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY AND GREENHOUSE GAS EXHAUST EMISSIONS OF MOTOR VEHICLES General...

Diagenesis and reservoir quality of the Lower Cretaceous Quantou Formation tight sandstones in the southern Songliao Basin, China

NASA Astrophysics Data System (ADS)

Xi, Kelai; Cao, Yingchang; Jahren, Jens; Zhu, Rukai; Bjørlykke, Knut; Haile, Beyene Girma; Zheng, Lijing; Hellevang, Helge

2015-12-01

The Lower Cretaceous Quantou Formation in the southern Songliao Basin is the typical tight oil sandstone in China. For effective exploration, appraisal and production from such a tight oil sandstone, the diagenesis and reservoir quality must be thoroughly studied first. The tight oil sandstone has been examined by a variety of methods, including core and thin section observation, XRD, SEM, CL, fluorescence, electron probing analysis, fluid inclusion and isotope testing and quantitative determination of reservoir properties. The sandstones are mostly lithic arkoses and feldspathic litharenites with fine to medium grain size and moderate to good sorting. The sandstones are dominated by feldspar, quartz, and volcanic rock fragments showing various stages of disintegration. The reservoir properties are quite poor, with low porosity (average 8.54%) and permeability (average 0.493 mD), small pore-throat radius (average 0.206 μm) and high displacement pressure (mostly higher than 1 MPa). The tight sandstone reservoirs have undergone significant diagenetic alterations such as compaction, feldspar dissolution, quartz cementation, carbonate cementation (mainly ferrocalcite and ankerite) and clay mineral alteration. As to the onset time, the oil emplacement was prior to the carbonate cementation but posterior to the quartz cementation and feldspar dissolution. The smectite to illite reaction and pressure solution at stylolites provide a most important silica sources for quartz cementation. Carbonate cements increase towards interbedded mudstones. Mechanical compaction has played a more important role than cementation in destroying the reservoir quality of the K1q4 sandstone reservoirs. Mixed-layer illite/smectite and illite reduced the porosity and permeability significantly, while chlorite preserved the porosity and permeability since it tends to be oil wet so that later carbonate cementation can be inhibited to some extent. It is likely that the oil emplacement occurred later than the tight rock formation (with the porosity close to 10%). However, thicker sandstone bodies (more than 2 m) constitute potential hydrocarbon reservoirs.

Confined Tension and Triaxial Extension Tests on Eglin High-Strength Concrete

DTIC Science & Technology

2014-10-17

specimen were filled with Devcon 5-Minute epoxy . We encased the specimen in a liquid-tight flexible jacket to exclude the confining fluid from any...sealed to the steel endcaps with epoxy and wire clamps. Figure 3. Schematic diagram of test specimen prepared for TXE testing. TXE tests are...150 MPa – we wrapped two Kevlar jackets (0.01 in thick) around the specimen prior to installing the polyolefin jacket (0.02 in thick). The Kevlar

Light Water Breeder Reactor fuel rod design and performance characteristics (LWBR Development Program)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Campbell, W.R.; Giovengo, J.F.

1987-10-01

Light Water Breeder Reactor (LWBR) fuel rods were designed to provide a reliable fuel system utilizing thorium/uranium-233 mixed-oxide fuel while simultaneously minimizing structural material to enhance fuel breeding. The fuel system was designed to be capable of operating successfully under both load follow and base load conditions. The breeding objective required thin-walled, low hafnium content Zircaloy cladding, tightly spaced fuel rods with a minimum number of support grid levels, and movable fuel rod bundles to supplant control rods. Specific fuel rod design considerations and their effects on performance capability are described. Successful completion of power operations to over 160 percentmore » of design lifetime including over 200 daily load follow cycles has proven the performance capability of the fuel system. 68 refs., 19 figs., 44 tabs.« less

Biochemical methane potential (BMP) tests: Reducing test time by early parameter estimation.

PubMed

Da Silva, C; Astals, S; Peces, M; Campos, J L; Guerrero, L

2018-01-01

Biochemical methane potential (BMP) test is a key analytical technique to assess the implementation and optimisation of anaerobic biotechnologies. However, this technique is characterised by long testing times (from 20 to >100days), which is not suitable for waste utilities, consulting companies or plants operators whose decision-making processes cannot be held for such a long time. This study develops a statistically robust mathematical strategy using sensitivity functions for early prediction of BMP first-order model parameters, i.e. methane yield (B 0 ) and kinetic constant rate (k). The minimum testing time for early parameter estimation showed a potential correlation with the k value, where (i) slowly biodegradable substrates (k≤0.1d -1 ) have a minimum testing times of ≥15days, (ii) moderately biodegradable substrates (0.1

40 CFR 600.010-08 - Vehicle test requirements and minimum data requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., US06, SC03 and Cold temperature FTP data from each subconfiguration included within the model type. (2... data requirements. 600.010-08 Section 600.010-08 Protection of Environment ENVIRONMENTAL PROTECTION... Provisions § 600.010-08 Vehicle test requirements and minimum data requirements. (a) Unless otherwise...

State Minimum Competency Testing Programs. Resource Catalog. Final Report.

ERIC Educational Resources Information Center

Mills, Gladys H.

Focusing on state-mandated minimum competency testing programs, this annotated bibliography cites 200 items selected from more than 700. The Resource Catalog is intended for state education policy makers and therefore includes resource and study guides; legislative and board action; conference speeches, reports and proceedings; curriculum guides,…

42 CFR 84.1150 - Exhalation valve leakage test; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Exhalation valve leakage test; minimum requirements. 84.1150 Section 84.1150 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust...

42 CFR 84.1150 - Exhalation valve leakage test; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Exhalation valve leakage test; minimum requirements. 84.1150 Section 84.1150 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust...

42 CFR 84.1150 - Exhalation valve leakage test; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Exhalation valve leakage test; minimum requirements. 84.1150 Section 84.1150 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust...

42 CFR 84.1150 - Exhalation valve leakage test; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Exhalation valve leakage test; minimum requirements. 84.1150 Section 84.1150 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust...

42 CFR 84.1150 - Exhalation valve leakage test; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Exhalation valve leakage test; minimum requirements. 84.1150 Section 84.1150 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Dust...

42 CFR 84.152 - Breathing tube test; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

...: (i) Be employed on Type C supplied-air respirators of the demand and pressure-demand class; and (ii... SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Supplied-Air Respirators § 84.152 Breathing tube test; minimum requirements. (a)(1) Type A and Type B supplied-air...

30 CFR 7.308 - Lockwasher equivalency test.

Code of Federal Regulations, 2014 CFR

2014-07-01

... hole and continuously and uniformly tightened at a speed not to exceed 30 rpm until the fastening's... cycles. (b) Acceptable performance. The minimum torque value required to start removal of the fastening from the installed position (minimum breakway torque) for any cycle of any test sample shall be greater...

30 CFR 7.308 - Lockwasher equivalency test.

Code of Federal Regulations, 2011 CFR

2011-07-01

... hole and continuously and uniformly tightened at a speed not to exceed 30 rpm until the fastening's... cycles. (b) Acceptable performance. The minimum torque value required to start removal of the fastening from the installed position (minimum breakway torque) for any cycle of any test sample shall be greater...

30 CFR 7.308 - Lockwasher equivalency test.

Code of Federal Regulations, 2013 CFR

2013-07-01

... hole and continuously and uniformly tightened at a speed not to exceed 30 rpm until the fastening's... cycles. (b) Acceptable performance. The minimum torque value required to start removal of the fastening from the installed position (minimum breakway torque) for any cycle of any test sample shall be greater...

30 CFR 7.308 - Lockwasher equivalency test.

Code of Federal Regulations, 2012 CFR

2012-07-01

... hole and continuously and uniformly tightened at a speed not to exceed 30 rpm until the fastening's... cycles. (b) Acceptable performance. The minimum torque value required to start removal of the fastening from the installed position (minimum breakway torque) for any cycle of any test sample shall be greater...

30 CFR 7.308 - Lockwasher equivalency test.

Code of Federal Regulations, 2010 CFR

2010-07-01

... hole and continuously and uniformly tightened at a speed not to exceed 30 rpm until the fastening's... cycles. (b) Acceptable performance. The minimum torque value required to start removal of the fastening from the installed position (minimum breakway torque) for any cycle of any test sample shall be greater...

40 CFR 60.37e - Compliance, performance testing, and monitoring guidelines.

Code of Federal Regulations, 2010 CFR

2010-07-01

... requirements: (1) Establish maximum charge rate and minimum secondary chamber temperature as site-specific... above the maximum charge rate or below the minimum secondary chamber temperature measured as 3-hour... below the minimum secondary chamber temperature shall constitute a violation of the established...

Localization of a new autosomal dominant retinitis pigmentosa gene on chromosome 17p screeningof candidate genes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Greenberg, J.; Goliath, R.; Shugart, Y.Y.

1994-09-01

A new gene locus for autosomal dominant retinitis pigmentosa (ADRP) on 17p has been identified in a large South African (SA) family consisting of 28 living affected individuals in 4 successive generations. This is the first ADRP gene to be reported from SA. The human recoverin (RCVN) gene, which codes for a retinal-specific protein important in recovery to the dark state after visual excitation, has been mapped to 17p13.1 and was considered as a prime candidate gene for the disorder in this family. Mutation screening (using 8 different electrophoretic conditions to resolve heteroduplexes and SSCPs) did not produce any evidencemore » of RCVN being involved in the pathogenesis of ADRP in this SA family. In addition, a mobility shift detected within exon 1 of the RCVN gene did not track with the ADRP phenotype. RP patients from 77 SA families and 30 normal individuals are being examined to establish the frequency of this polymorphism in the SA population. Highly polymorphic markers from 17p13 are now being sought in order to establish the minimum region containing this novel ADRP-SA gene. Two additional recently described retinal-expressed cDNAs, guanylyl cyclase and pigment epithelium-derived factor, which map to 17p13.1, will be tested for tight linkage to ADRP-SA.« less

Preparing for uncertainty: toward managing fluvial geomorphic assessment of Massachusetts rivers

NASA Astrophysics Data System (ADS)

Hatch, C. E.; Mabee, S. B.; Slovin, N. B.; Vogel, E.

2014-12-01

Climate scientists predict (and have already observed) that in the Northeastern U.S., individual storms may be more intense, and that there will be more precipitation on an annual basis. In steep post-glacial terrain, erosion caused by floodwaters is the largest destructive force during high-intensity storm events, and the force most likely to drive major morphological changes to riverbanks and channels. What remains uncertain is which watersheds or river reaches may be subjected to increased damage from more intense storms. This presents a challenge for scientific outreach and management. Many New England states have developed systems for delineating the potentially geomorphically active zones adjacent to rivers, and Vermont has an excellent assessment and land use management system informed by process-based fluvial geomorphologic science. To date, however, Massachusetts has neither. In this project we survey existing protocols for accurately predicting locations of fluvial erosion hazard, including using LiDAR and DEM models to extract basic morphologic metrics. Particularly in states or landscapes with high river density, and during a time of tight fiscal constraints, managers need automated methods that require a minimum of expert input. We test these methods in the Deerfield river watershed in Massachusetts and Vermont, and integrate our knowledge with that of the basin's agricultural and floodplain stakeholders. The results will inform development of a comprehensive river assessment and land use management system for the state of Massachusetts.

New Jersey Statewide Minimum Standards: Results from the Program's Second Year. Occasional Papers in Education.

ERIC Educational Resources Information Center

Koffler, Stephen L.

Results of the second year of the New Jersey Minimum Basic Skills Tests in reading and mathematics, mandated by the New Jersey Public School Education Act of 1975, are summarized. Approximately 397,000 students in grades three, six, nine, and eleven were tested. Results of the tests showed that a smaller percentage of sixth-grade students met…

Association Between Plantar Fasciitis and Isolated Gastrocnemius Tightness.

PubMed

Nakale, Ngenomeulu T; Strydom, Andrew; Saragas, Nick P; Ferrao, Paulo N F

2018-03-01

An association between plantar fasciitis and isolated gastrocnemius tightness (IGT) has been postulated in the literature; however, there have been few studies to prove this relationship. This prospective cross-sectional cohort study was aimed at determining the association between plantar fasciitis and IGT. Three groups comprising 45 patients with plantar fasciitis (group 1), 117 patients with foot and ankle pathology other than plantar fasciitis (group 2), and 61 patients without foot and ankle pathology (group 3) were examined for the presence of IGT using the Silfverskiöld test. Statistical tests included chi-square test, Student t test, and analysis of variance. Of the patients, 101 (45.3%) had IGT: 36 (80%) in group 1, 53 (45.3%) in group 2, and 12 (19.7%) in group 3. The difference in IGT prevalence between the groups was statistically significant at P < .001. The prevalence of IGT was similar between acute and chronic plantar fasciitis at 78.9% and 80.6%, respectively. There was a very strong association between plantar fasciitis and IGT using group 3 as a reference. This study suggests that IGT should be actively sought out and managed in patients with plantar fasciitis. Level II, cross-sectional cohort prospective study.

Targeted Lymphoma Cell Death by Novel Signal Transduction Modifications

DTIC Science & Technology

2011-07-01

CD22), and mediating the secretion of a pro-apoptotic soluble factor. To test this hypothesis we used immobilized peptide 41 to mediate...the syntheses. The columns were tightly capped and mixed by tumbling for 2 h to overnight at room temperature. The ninhydrin test (Kaiser et al. 1970...was used to test for the completion of the coupling reaction. For those coupling reactions determined to be incomplete, fresh BOP, DIEA, and HOBt

40 CFR 65.85 - Procedures.

Code of Federal Regulations, 2014 CFR

2014-07-01

... permit limit applicable to the process vent. (4) Design analysis based on accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or properties. (5) All data... tested for vapor tightness. (b) Engineering assessment. Engineering assessment to determine if a vent...

40 CFR 65.85 - Procedures.

Code of Federal Regulations, 2012 CFR

2012-07-01

... permit limit applicable to the process vent. (4) Design analysis based on accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or properties. (5) All data... tested for vapor tightness. (b) Engineering assessment. Engineering assessment to determine if a vent...

40 CFR 65.85 - Procedures.

Code of Federal Regulations, 2011 CFR

2011-07-01

... permit limit applicable to the process vent. (4) Design analysis based on accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or properties. (5) All data... tested for vapor tightness. (b) Engineering assessment. Engineering assessment to determine if a vent...

40 CFR 65.85 - Procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... permit limit applicable to the process vent. (4) Design analysis based on accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or properties. (5) All data... tested for vapor tightness. (b) Engineering assessment. Engineering assessment to determine if a vent...

40 CFR 65.85 - Procedures.

Code of Federal Regulations, 2013 CFR

2013-07-01

... permit limit applicable to the process vent. (4) Design analysis based on accepted chemical engineering principles, measurable process parameters, or physical or chemical laws or properties. (5) All data... tested for vapor tightness. (b) Engineering assessment. Engineering assessment to determine if a vent...

40 CFR 600.010-86 - Vehicle test requirements and minimum data requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... base level, and (iii) For additional model types established under § 600.207(a)(2), data from each... data requirements. 600.010-86 Section 600.010-86 Protection of Environment ENVIRONMENTAL PROTECTION... Provisions § 600.010-86 Vehicle test requirements and minimum data requirements. (a) For each certification...

Minimum Competency Testing: Guidelines for Policymakers and Citizens.

ERIC Educational Resources Information Center

Gray, Dennis

Intended to help the laity find their way through the confusion and controversy surrounding minimum competency testing (MCT), this paper explains what MCT is, acknowledges its limitations, weighs the criticisms, and shows how MCT may be used constructively for the benefit of students and for the improvement of schools. Highlights from the paper…

NIE's Study of Minimum Competency Testing: A Process for the Clarification of Issues.

ERIC Educational Resources Information Center

Herndon, Enid

The National Institute of Education's (NIE) process of studying minimum competency testing (MCT) includes: (1) a clarification hearing to provide a public forum to discuss divergent views on salient issues related to MCT programs; (2) two investigative teams to explore the different perspectives on the issues, build comprehensive cases which…

42 CFR 84.1147 - Silica mist test for dust, fume, and mist respirators; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Silica mist test for dust, fume, and mist respirators; minimum requirements. 84.1147 Section 84.1147 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF...

42 CFR 84.1146 - Lead fume test for dust, fume, and mist respirators; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Lead fume test for dust, fume, and mist respirators; minimum requirements. 84.1146 Section 84.1146 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF...

42 CFR 84.1158 - Dust, fume, and mist tests; respirators with filters; minimum requirements; general.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Dust, fume, and mist tests; respirators with filters; minimum requirements; general. 84.1158 Section 84.1158 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES...

42 CFR 84.1149 - Airflow resistance tests; all dust, fume, and mist respirators; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Airflow resistance tests; all dust, fume, and mist respirators; minimum requirements. 84.1149 Section 84.1149 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF...

42 CFR 84.1145 - Silica dust test; non-powered single-use dust respirators; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Silica dust test; non-powered single-use dust respirators; minimum requirements. 84.1145 Section 84.1145 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF...

42 CFR 84.1145 - Silica dust test; non-powered single-use dust respirators; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Silica dust test; non-powered single-use dust respirators; minimum requirements. 84.1145 Section 84.1145 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF...

42 CFR 84.1149 - Airflow resistance tests; all dust, fume, and mist respirators; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Airflow resistance tests; all dust, fume, and mist respirators; minimum requirements. 84.1149 Section 84.1149 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF...

42 CFR 84.1147 - Silica mist test for dust, fume, and mist respirators; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Silica mist test for dust, fume, and mist respirators; minimum requirements. 84.1147 Section 84.1147 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF...

42 CFR 84.1147 - Silica mist test for dust, fume, and mist respirators; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Silica mist test for dust, fume, and mist respirators; minimum requirements. 84.1147 Section 84.1147 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF...

42 CFR 84.1145 - Silica dust test; non-powered single-use dust respirators; minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Silica dust test; non-powered single-use dust respirators; minimum requirements. 84.1145 Section 84.1145 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF...

42 CFR 84.1158 - Dust, fume, and mist tests; respirators with filters; minimum requirements; general.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Dust, fume, and mist tests; respirators with filters; minimum requirements; general. 84.1158 Section 84.1158 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES...

42 CFR 84.1149 - Airflow resistance tests; all dust, fume, and mist respirators; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Airflow resistance tests; all dust, fume, and mist respirators; minimum requirements. 84.1149 Section 84.1149 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF...

42 CFR 84.1158 - Dust, fume, and mist tests; respirators with filters; minimum requirements; general.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Dust, fume, and mist tests; respirators with filters; minimum requirements; general. 84.1158 Section 84.1158 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES...

42 CFR 84.1146 - Lead fume test for dust, fume, and mist respirators; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Lead fume test for dust, fume, and mist respirators; minimum requirements. 84.1146 Section 84.1146 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF...

42 CFR 84.1147 - Silica mist test for dust, fume, and mist respirators; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Silica mist test for dust, fume, and mist respirators; minimum requirements. 84.1147 Section 84.1147 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF...

42 CFR 84.1158 - Dust, fume, and mist tests; respirators with filters; minimum requirements; general.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Dust, fume, and mist tests; respirators with filters; minimum requirements; general. 84.1158 Section 84.1158 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES...

42 CFR 84.1149 - Airflow resistance tests; all dust, fume, and mist respirators; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Airflow resistance tests; all dust, fume, and mist respirators; minimum requirements. 84.1149 Section 84.1149 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF...

42 CFR 84.1147 - Silica mist test for dust, fume, and mist respirators; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Silica mist test for dust, fume, and mist respirators; minimum requirements. 84.1147 Section 84.1147 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF...

42 CFR 84.1146 - Lead fume test for dust, fume, and mist respirators; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Lead fume test for dust, fume, and mist respirators; minimum requirements. 84.1146 Section 84.1146 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF...

42 CFR 84.1146 - Lead fume test for dust, fume, and mist respirators; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Lead fume test for dust, fume, and mist respirators; minimum requirements. 84.1146 Section 84.1146 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF...

42 CFR 84.1158 - Dust, fume, and mist tests; respirators with filters; minimum requirements; general.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Dust, fume, and mist tests; respirators with filters; minimum requirements; general. 84.1158 Section 84.1158 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES...

42 CFR 84.1149 - Airflow resistance tests; all dust, fume, and mist respirators; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Airflow resistance tests; all dust, fume, and mist respirators; minimum requirements. 84.1149 Section 84.1149 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF...

42 CFR 84.1145 - Silica dust test; non-powered single-use dust respirators; minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Silica dust test; non-powered single-use dust respirators; minimum requirements. 84.1145 Section 84.1145 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF...

42 CFR 84.1145 - Silica dust test; non-powered single-use dust respirators; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Silica dust test; non-powered single-use dust respirators; minimum requirements. 84.1145 Section 84.1145 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF...

42 CFR 84.1146 - Lead fume test for dust, fume, and mist respirators; minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Lead fume test for dust, fume, and mist respirators; minimum requirements. 84.1146 Section 84.1146 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF...

29 CFR 1926.752 - Site layout, site-specific erection plan and construction sequence.

Code of Federal Regulations, 2011 CFR

2011-07-01

... standard test method of field-cured samples, either 75 percent of the intended minimum compressive design... the basis of an appropriate ASTM standard test method of field-cured samples, either 75 percent of the intended minimum compressive design strength or sufficient strength to support the loads imposed during...

29 CFR 1926.752 - Site layout, site-specific erection plan and construction sequence.

Code of Federal Regulations, 2013 CFR

2013-07-01

... standard test method of field-cured samples, either 75 percent of the intended minimum compressive design... the basis of an appropriate ASTM standard test method of field-cured samples, either 75 percent of the intended minimum compressive design strength or sufficient strength to support the loads imposed during...

29 CFR 1926.752 - Site layout, site-specific erection plan and construction sequence.

Code of Federal Regulations, 2012 CFR

2012-07-01

... standard test method of field-cured samples, either 75 percent of the intended minimum compressive design... the basis of an appropriate ASTM standard test method of field-cured samples, either 75 percent of the intended minimum compressive design strength or sufficient strength to support the loads imposed during...

29 CFR 1926.752 - Site layout, site-specific erection plan and construction sequence.

Code of Federal Regulations, 2010 CFR

2010-07-01

... standard test method of field-cured samples, either 75 percent of the intended minimum compressive design... the basis of an appropriate ASTM standard test method of field-cured samples, either 75 percent of the intended minimum compressive design strength or sufficient strength to support the loads imposed during...

29 CFR 1926.752 - Site layout, site-specific erection plan and construction sequence.

Code of Federal Regulations, 2014 CFR

2014-07-01

... standard test method of field-cured samples, either 75 percent of the intended minimum compressive design... the basis of an appropriate ASTM standard test method of field-cured samples, either 75 percent of the intended minimum compressive design strength or sufficient strength to support the loads imposed during...

Minimum Competency Testing Clarification Hearing (July 9th, 1981).

ERIC Educational Resources Information Center

National Inst. of Education (ED), Washington, DC.

Barbara Jordan served as the hearing officer for three-day adversary evaluation hearings about the pros and cons of minimum competency testing (MCT). This report is the complete transcript of the second day of proceedings. The pro team, lead by James Popham, began by presenting representatives of four states (Florida, California, Texas, and…

Passive versus active stretching of hip flexor muscles in subjects with limited hip extension: a randomized clinical trial.

PubMed

Winters, Michael V; Blake, Charles G; Trost, Jennifer S; Marcello-Brinker, Toni B; Lowe, Lynne M; Garber, Matthew B; Wainner, Robert S

2004-09-01

Active stretching is purported to stretch the shortened muscle and simultaneously strengthen the antagonist muscle. The purpose of this study was to determine whether active and passive stretching results in a difference between groups at improving hip extension range of motion in patients with hip flexor muscle tightness. Thirty-three patients with low back pain and lower-extremity injuries who showed decreased range of motion, presumably due to hip flexor muscle tightness, completed the study. The subjects, who had a mean age of 23.6 years (SD = 5.3, range = 18-25), were randomly assigned to either an active home stretching group or a passive home stretching group. Hip extension range of motion was measured with the subjects in the modified Thomas test position at baseline and 3 and 6 weeks after the start of the study. Range of motion in both groups improved over time, but there were no differences between groups. The results indicate that passive and active stretching are equally effective for increasing range of motion, presumably due to increased flexibility of tight hip flexor muscles. Whether the 2 methods equally improve flexibility of other muscle groups or whether active stretching improves the function of the antagonist muscles is not known. Active and passive stretching both appeared to increase the flexibility of tight hip flexor muscles in patients with musculoskeletal impairments.

Satellite derived estimates of forest leaf area index in South-west Western Australia are not tightly coupled to inter-annual variations in rainfall: implications for groundwater decline in a drying climate.

NASA Astrophysics Data System (ADS)

Smettem, Keith; Waring, Richard; Callow, Nik; Wilson, Melissa; Mu, Qiaozhen

2013-04-01

There is increasing concern that widespread forest decline could occur in regions of the world where droughts are predicted to increase in frequency and severity as a result of climate change. Ecological optimality proposes that the long term average canopy size of undisturbed perennial vegetation is tightly coupled to climate. The average annual leaf area index (LAI) is an indicator of canopy cover and the difference between the annual maximum and minimum LAI is an indicator of annual leaf turnover. In this study we analysed satellite-derived estimates of monthly LAI across forested coastal catchments of South-west Western Australia over a 12 year period (2000-2011) that included the driest year on record for the last 60 years. We observed that over the 12 year study period, the spatial pattern of average annual satellite-derived LAI values was linearly related to mean annual rainfall. However, inter-annual changes to LAI in response to changes in annual rainfall were far less than expected from the long-term LAI-rainfall trend. This buffered response was investigated using a physiological growth model and attributed to availability of deep soil moisture and/or groundwater storage. The maintenance of high LAIs may be linked to a long term decline in areal average underground water storage storage and diminished summer flows, with a trend towards more ephemeral flow regimes.

Thermal Design, Analysis, and Testing of the Quench Module Insert Bread Board

NASA Technical Reports Server (NTRS)

Breeding Shawn; Khodabandeh, Julia; Turner, Larry D. (Technical Monitor)

2001-01-01

The science requirements for materials processing is to provide the desired PI requirements of thermal gradient, solid/liquid interface front velocity for a given processing temperature desired by the PI. Processing is performed by translating the furnace with the sample in a stationary position to minimize any disturbances to the solid/liquid interface front during steady state processing. Typical sample materials for this metals and alloys furnace are lead-tin alloys, lead-antimony alloys, and aluminum alloys. Samples must be safe to process and therefore typically are contained with hermetically sealed cartridge tubes (gas tight) with inner ceramic liners (liquid tight) to prevent contamination and/or reaction of the sample material with the cartridge tube.

Enforcing dust mass conservation in 3D simulations of tightly coupled grains with the PHANTOM SPH code

NASA Astrophysics Data System (ADS)

Ballabio, G.; Dipierro, G.; Veronesi, B.; Lodato, G.; Hutchison, M.; Laibe, G.; Price, D. J.

2018-06-01

We describe a new implementation of the one-fluid method in the SPH code PHANTOM to simulate the dynamics of dust grains in gas protoplanetary discs. We revise and extend previously developed algorithms by computing the evolution of a new fluid quantity that produces a more accurate and numerically controlled evolution of the dust dynamics. Moreover, by limiting the stopping time of uncoupled grains that violate the assumptions of the terminal velocity approximation, we avoid fatal numerical errors in mass conservation. We test and validate our new algorithm by running 3D SPH simulations of a large range of disc models with tightly and marginally coupled grains.

A Case of Cardiac Cephalalgia Showing Reversible Coronary Vasospasm on Coronary Angiogram

PubMed Central

Yang, YoungSoon; Jin, Dong Gyu; Jang, Il Mi; Jang, YoungHee; Na, Hae Ri; Kim, SanYun

2010-01-01

Background Under certain conditions, exertional headaches may reflect coronary ischemia. Case Report A 44-year-old woman developed intermittent exercise-induced headaches with chest tightness over a period of 10 months. Cardiac catheterization followed by acetylcholine provocation demonstrated a right coronary artery spasm with chest tightness, headache, and ischemic effect of continuous electrocardiography changes. The patient's headache disappeared following intra-arterial nitroglycerine injection. Conclusions A coronary angiogram with provocation study revealed variant angina and cardiac cephalalgia, as per the International Classification of Headache Disorders (code 10.6). We report herein a patient with cardiac cephalalgia that manifested as reversible coronary vasospasm following an acetylcholine provocation test. PMID:20607049

Grappling with Weight Cutting. The Wisconsin Wrestling Minimum Weight Project.

ERIC Educational Resources Information Center

Oppliger, Robert A.; And Others

1995-01-01

In response to a new state rule, the Wisconsin Minimum Weight Project curtails weight cutting among high school wrestlers. The project uses skinfold testing to determine a minimum competitive weight and nutrition education to help the wrestler diet safety. It serves as a model for other states and other sports. (Author/SM)

Shuttle payload minimum cost vibroacoustic tests

NASA Technical Reports Server (NTRS)

Stahle, C. V.; Gongloff, H. R.; Young, J. P.; Keegan, W. B.

1977-01-01

This paper is directed toward the development of the methodology needed to evaluate cost effective vibroacoustic test plans for Shuttle Spacelab payloads. Statistical decision theory is used to quantitatively evaluate seven alternate test plans by deriving optimum test levels and the expected cost for each multiple mission payload considered. The results indicate that minimum costs can vary by as much as $6 million for the various test plans. The lowest cost approach eliminates component testing and maintains flight vibration reliability by performing subassembly tests at a relatively high acoustic level. Test plans using system testing or combinations of component and assembly level testing are attractive alternatives. Component testing alone is shown not to be cost effective.

Noseband Use in Equestrian Sports – An International Study

PubMed Central

Doherty, Orla

2017-01-01

Nosebands are used by riders to prevent the horse from opening its mouth, to increase control and, in some cases, to comply with the competition rules. While equestrian texts traditionally recommend that two adult human fingers should be able to fit under a fastened noseband, noseband tightness levels are not, in general, regulated in competition. Possible detrimental consequences for the horse, of excessively tight nosebands, include discomfort, pain or tissue damage. The current study investigated noseband usage in equestrian competition. Data regarding noseband type, position, width and tightness were collected from 750 horses in eventing (n = 354), dressage (n = 334) and performance hunter (n = 62) competitions in Ireland, England and Belgium. Data were collected immediately before or after the performance. Using the ISES taper gauge as a guide, results were classified according to the number of ‘fingers’ that could fit under the noseband at the nasal planum, and assigned to six groups: greater than 2 fingers; 2 fingers; 1.5 fingers; 1 finger; 0.5 fingers; zero fingers. A calliper was used to measure noseband width and position relative to the facial crest. The data were not normally distributed so Kruskall-Wallis and Mann-Whitney tests were used. In all, 44% of horses fell into the zero fingers classification while only 7% were in the two fingers classification. Significant differences emerged between disciplines (p<0.001), with the highest levels of noseband tightness measured among eventers followed by dressage horses with lowest levels among performance hunters. Noseband tightness did not differ significantly with horse age (p>0.05), which ranged from 4 to 19 years. The flash noseband was the most commonly used noseband (n = 326) and was significantly tighter than the cavesson (p < 0.001), drop noseband (p < 0.001) and the Micklem (p < 0.005). Noseband width ranged from 10 to 50 mm. Noseband position varied widely with the distance between the facial crest and upper noseband margin ranging from 0 to 70 mm. The high proportion of very tight nosebands found in this study raises concerns regarding the short and long term behavioural and physiological consequences of such tight nosebands are for the horse. Although these data are currently lacking, the findings are of concern. PMID:28045961

Circadian dysregulation disrupts bile acid homeostasis

USDA-ARS?s Scientific Manuscript database

Bile acids are potentially toxic compounds and their levels of hepatic production, uptake, and export are tightly regulated by many inputs, including circadian rhythm. We tested the impact of disrupting the peripheral circadian clock on integral steps of bile acid homeostasis. Both restricted feedi...

Recent clinical advances in diabetic polyneuropathy.

PubMed

Horowitz, Steven H

2006-10-01

Recent dramatic increases in the incidence and prevalence of diabetes make an understanding of chronic symmetric sensorimotor diabetic polyneuropathy, the most common and problematic of chronic diabetic complications, essential for a wide range of medical practitioners. The demonstration of neuropathic dysfunction in patients with prediabetes or impaired glucose tolerance emphasizes the susceptibility of peripheral nerve fibers, especially small A delta fibers and C fibers, to relatively mild, short-duration hyperglycemia. New testing can reveal peripheral nerve dysfunction prior to clinical neuropathic symptoms and signs. In the absence of effective medications to halt or reverse nerve damage or promote nerve regeneration, early diagnosis of diabetic polyneuropathy, followed by tight glycemic control with diet and exercise, offers the best opportunity to prevent progressive symptoms of sensory loss, pain, autonomic dysfunction, ulcerations, and amputations. Some patients with impaired glucose tolerance have a reversal of neuropathic features with tight glycemic control. Nonpharmacologic therapies for neuropathic pain in diabetic polyneuropathy appear promising. Tight glycemic control, especially early in diabetes, is the best approach to minimizing the prevalence and severity of diabetic polyneuropathy and makes research into the deleterious effects of even mild hyperglycemia imperative.

Flying After Conducting an Aircraft Excessive Cabin Leakage Test.

PubMed

Houston, Stephen; Wilkinson, Elizabeth

2016-09-01

Aviation medical specialists should be aware that commercial airline aircraft engineers may undertake a 'dive equivalent' operation while conducting maintenance activities on the ground. We present a worked example of an occupational risk assessment to determine a minimum safe preflight surface interval (PFSI) for an engineer before flying home to base after conducting an Excessive Cabin Leakage Test (ECLT) on an unserviceable aircraft overseas. We use published dive tables to determine the minimum safe PFSI. The estimated maximum depth acquired during the procedure varies between 10 and 20 fsw and the typical estimated bottom time varies between 26 and 53 min for the aircraft types operated by the airline. Published dive tables suggest that no minimum PFSI is required for such a dive profile. Diving tables suggest that no minimum PFSI is required for the typical ECLT dive profile within the airline; however, having conducted a risk assessment, which considered peak altitude exposure during commercial flight, the worst-case scenario test dive profile, the variability of interindividual inert gas retention, and our existing policy among other occupational groups within the airline, we advised that, in the absence of a bespoke assessment of the particular circumstances on the day, the minimum PFSI after conducting ECLT should be 24 h. Houston S, Wilkinson E. Flying after conducting an aircraft excessive cabin leakage test. Aerosp Med Hum Perform. 2016; 87(9):816-820.

DIF Detection Using Multiple-Group Categorical CFA with Minimum Free Baseline Approach

ERIC Educational Resources Information Center

Chang, Yu-Wei; Huang, Wei-Kang; Tsai, Rung-Ching

2015-01-01

The aim of this study is to assess the efficiency of using the multiple-group categorical confirmatory factor analysis (MCCFA) and the robust chi-square difference test in differential item functioning (DIF) detection for polytomous items under the minimum free baseline strategy. While testing for DIF items, despite the strong assumption that all…

A Study of Minimum Competency Programs. Final Comprehensive Report. Vol. 1. Vol. 2.

ERIC Educational Resources Information Center

Gorth, William Phillip; Perkins, Marcy R.

The status of minimum competency testing programs, as of June 30, 1979, is given through descriptions of 31 state programs and 20 local district programs. For each program, the following information is provided: legislative and policy history; implementation phase; goals; competencies to be tested; standards and standard setting; target groups and…

49 CFR 178.47 - Specification 4DS welded stainless steel cylinders for aircraft use.

Code of Federal Regulations, 2011 CFR

2011-10-01

... the formula: S = PD / 4tE Where: S = Wall stress in psi; P = Test pressure prescribed for water jacket... stainless steel sphere (two seamless hemispheres) or circumferentially welded cylinder both with a water... thickness. The minimum wall thickness must be such that the wall stress at the minimum specified test...

A Study of Minimum Competency Testing Programs. Final Program Development Resource Document.

ERIC Educational Resources Information Center

Gorth, William Phillip; Perkins, Marcy R.

This resource document represents the integration of both practice and theory related to minimum competency testing (MCT), and is largely based on information collected in a nationwide survey of MCT programs. Chapter 1, To Implement or Not to Implement MCT, by Marcy R. Perkins, presents a definition of MCT and a discussion of the perceived…

76 FR 20536 - Protocol Gas Verification Program and Minimum Competency Requirements for Air Emission Testing

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-13

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 75 [EPA-HQ-OAR-2009-0837; FRL-9280-9] RIN 2060-AQ06 Protocol Gas Verification Program and Minimum Competency Requirements for Air Emission Testing Correction In rule document 2011-6216 appearing on pages 17288-17325 in the issue of Monday, March 28, 2011...

42 CFR 84.1144 - Silica dust test for dust, fume, and mist respirators; single-use or reusable filters; minimum...

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Silica dust test for dust, fume, and mist respirators; single-use or reusable filters; minimum requirements. 84.1144 Section 84.1144 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH...

42 CFR 84.1144 - Silica dust test for dust, fume, and mist respirators; single-use or reusable filters; minimum...

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Silica dust test for dust, fume, and mist respirators; single-use or reusable filters; minimum requirements. 84.1144 Section 84.1144 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH...

42 CFR 84.1144 - Silica dust test for dust, fume, and mist respirators; single-use or reusable filters; minimum...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Silica dust test for dust, fume, and mist respirators; single-use or reusable filters; minimum requirements. 84.1144 Section 84.1144 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH...

42 CFR 84.1144 - Silica dust test for dust, fume, and mist respirators; single-use or reusable filters; minimum...

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Silica dust test for dust, fume, and mist respirators; single-use or reusable filters; minimum requirements. 84.1144 Section 84.1144 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH...

42 CFR 84.1144 - Silica dust test for dust, fume, and mist respirators; single-use or reusable filters; minimum...

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Silica dust test for dust, fume, and mist respirators; single-use or reusable filters; minimum requirements. 84.1144 Section 84.1144 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OCCUPATIONAL SAFETY AND HEALTH RESEARCH...

75 FR 22150 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-27

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Substance Abuse and Mental Health Services Administration Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for Federal Agencies Correction In notice document 2010-7170 beginning on page 16813 in the issue of Friday, April 2...

Tight swimming trunks to prevent post scrotal surgery: an experimental justification.

PubMed

Al-Abed, Yahya A; Carr, Thomas W

2013-01-01

To conduct a study to measure the pressure effects of the different scrotal supports applied on a simulated expanding scrotal hematoma. We created a model of an expanding hematoma with simultaneous pressure recording using a urodynamics system. Pressures were recorded independently first without application of any support. Then, three types of scrotal supports were tested, including Euron Net Knickers, scrotal suspensory bandage, and tight swimming trunks brand Speedo® brief and shorts. Subsequent pressures were recorded using the model created, which was applied inside the supports worn by two male volunteers A and B. Without any external compression, the pressure inside the simulated expanding hematoma "balloon" reached a maximum of 15 cmH2O. The pressures measured whilst wearing "Netelast knickers" in both subjects A and B reached a maximum of 15 cmH2O suggesting that this garment exerted no measurable compression. The suspensory scrotal support was then tested in both subjects. As the balloon started to fill with saline, the simulated hematoma pushed the scrotal support forward resulting in falling of the balloon outside the scrotal support. Subsequently, Speedo® briefs and shorts were tested. With Speedo® briefs, maximum filling pressures of 49 cmH2O and 40 cmH2O were reached in subjects A and B, respectively. When using Speedo® shorts, however, maximum pressures of 55 cmH2O in subject A and 54 cmH2O in subject B were reached at the end of the balloon filling to 300 mL of saline. The use of tight swimming trunks (Speedo®) has led to satisfactory results in the prevention of hematoma post scrotal surgery.

Brillouin characterisation of optical microfibers

NASA Astrophysics Data System (ADS)

Farhan, Kazi Tasneem

The sleek shape of microfiber helps it to confine the light tightly and generate high nonlinear effect, which is 1000 times higher than the standard fiber. This project focuses on fabricating microfiber samples with different taper lengths and different waist diameter from three different kinds of fiber, single mode fiber (SMF), Gedoped and Ga-doped. All the samples were characterised in terms of Brillouin scattering and Brillouin gain and Brillouin lasing, and compared to each other and to the SMF fiber. Stimulated Brillouin scattering (SBS) has been demonstrated for short microfibers of length less than 10cm. The nonlinear effects of long tapers have not been reported yet. The theoretical perspective related to microfibers indicate the possibility of generation of stronger signals and newer frequencies. Among the many nonlinear effects Brillouin scattering is the easiest to observe and has not been studied using long microfibers until now. In this project microfibers of different lengths and waist diameter are fabricated. The microfibers were made from three different kinds of fiber: SMF, Germanium doped (Ge-doped) and Gallium doped (Ga-doped). The shapes of the fabricated samples are profiled to match the shape with the numerically simulated shape. The power performances are studied so that samples with minimum losses are used for Brillouin characterisation. The first experiment uses the microfiber samples for testing and recording the changes in Stokes generation for the different dimensions of each sample in a Brillouin scattering setup. These microfibers are tested in s second experiment of Brillouin laser setup to explore their possibilities of lasing. In the third experiment the microfibers are used in a pump probe technique setup to spatially measure the Brillouin gain along the length of each sample.

Stacked endoplasmic reticulum sheets are connected by helicoidal membrane motifs

PubMed Central

Terasaki, Mark; Shemesh, Tom; Kasthuri, Narayanan; Klemm, Robin W.; Schalek, Richard; Hayworth, Kenneth J.; Hand, Arthur R.; Yankova, Maya; Huber, Greg; Lichtman, Jeff W.; Rapoport, Tom A.; Kozlov, Michael M.

2013-01-01

The endoplasmic reticulum (ER) often forms stacked membrane sheets, an arrangement that is likely required to accommodate a maximum of membrane-bound polysomes for secretory protein synthesis. How sheets are stacked is unknown. Here, we used novel staining and automated ultra-thin sectioning electron microscopy methods to analyze stacked ER sheets in neuronal cells and secretory salivary gland cells of mice. Our results show that stacked ER sheets form a continuous membrane system in which the sheets are connected by twisted membrane surfaces with helical edges of left- or right-handedness. The three-dimensional structure of tightly stacked ER sheets resembles a parking garage, in which the different levels are connected by helicoidal ramps. A theoretical model explains the experimental observations and indicates that the structure corresponds to a minimum of elastic energy of sheet edges and surfaces. The structure allows the dense packing of ER sheets in the restricted space of a cell. PMID:23870120

Formation of fivefold axes in the FCC-metal nanoclusters

NASA Astrophysics Data System (ADS)

Myasnichenko, Vladimir S.; Starostenkov, Mikhail D.

2012-11-01

Formation of atomistic structures of metallic Cu, Au, Ag clusters and bimetallic Cu-Au clusters was studied with the help of molecular dynamics using the many-body tight-binding interatomic potential. The simulation of the crystallization process of clusters with the number of atoms ranging from 300 to 1092 was carried out. The most stable configurations of atoms in the system, corresponding to the minimum of potential energy, was found during super-fast cooling from 1000 K. Atoms corresponding to fcc, hcp, and Ih phases were identified by the method of common neighbor analysis. Incomplete icosahedral core can be discovered at the intersection of one of the Ih axes with the surface of monometallic cluster. The decahedron-shaped structure of bimetallic Cu-Au cluster with seven completed icosahedral cores was obtained. The principles of the construction of small bimetallic clusters with icosahedral symmetry and increased fractal dimensionality were offered.

Regulated Eukaryotic DNA Replication Origin Firing with Purified Proteins

PubMed Central

Yeeles, Joseph T.P.; Deegan, Tom D.; Janska, Agnieszka; Early, Anne; Diffley, John F. X.

2016-01-01

Eukaryotic cells initiate DNA replication from multiple origins, which must be tightly regulated to promote precise genome duplication in every cell cycle. To accomplish this, initiation is partitioned into two temporally discrete steps: a double hexameric MCM complex is first loaded at replication origins during G1 phase, and then converted to the active CMG (Cdc45, MCM, GINS) helicase during S phase. Here we describe the reconstitution of budding yeast DNA replication initiation with 16 purified replication factors, made from 42 polypeptides. Origin-dependent initiation recapitulates regulation seen in vivo. Cyclin dependent kinase (CDK) inhibits MCM loading by phosphorylating the origin recognition complex (ORC) and promotes CMG formation by phosphorylating Sld2 and Sld3. Dbf4 dependent kinase (DDK) promotes replication by phosphorylating MCM, and can act either before or after CDK. These experiments define the minimum complement of proteins, protein kinase substrates and co-factors required for regulated eukaryotic DNA replication. PMID:25739503

Regulated eukaryotic DNA replication origin firing with purified proteins.

PubMed

Yeeles, Joseph T P; Deegan, Tom D; Janska, Agnieszka; Early, Anne; Diffley, John F X

2015-03-26

Eukaryotic cells initiate DNA replication from multiple origins, which must be tightly regulated to promote precise genome duplication in every cell cycle. To accomplish this, initiation is partitioned into two temporally discrete steps: a double hexameric minichromosome maintenance (MCM) complex is first loaded at replication origins during G1 phase, and then converted to the active CMG (Cdc45-MCM-GINS) helicase during S phase. Here we describe the reconstitution of budding yeast DNA replication initiation with 16 purified replication factors, made from 42 polypeptides. Origin-dependent initiation recapitulates regulation seen in vivo. Cyclin-dependent kinase (CDK) inhibits MCM loading by phosphorylating the origin recognition complex (ORC) and promotes CMG formation by phosphorylating Sld2 and Sld3. Dbf4-dependent kinase (DDK) promotes replication by phosphorylating MCM, and can act either before or after CDK. These experiments define the minimum complement of proteins, protein kinase substrates and co-factors required for regulated eukaryotic DNA replication.

Field effect transistors based on phosphorene nanoribbon with selective edge-adsorption: A first-principles study

NASA Astrophysics Data System (ADS)

Hu, Mengli; Yang, Zhixiong; Zhou, Wenzhe; Li, Aolin; Pan, Jiangling; Ouyang, Fangping

2018-04-01

By using density functional theory (DFT) and nonequilibrium Green's function (NEGF), field effect transistor (FET) based on zigzag shaped phosphorene nanoribbons (ZPNR) are investigated. The FETs are constructed with bare-edged ZPNRs as electrodes and H, Cl or OH adsorbed ZPNRs as channel. It is found FETs with the three kinds of channel show similar transport properties. The FET is p-type with a maximum current on/off ratio of 104 and a minimum off-current of 1 nA. The working mode of FETs is dependent on the parity of channel length. It can be either enhancement mode or depletion mode and the off-state current shows an even-odd oscillation. The current oscillations are interpreted with density of states (DOS) analysis and methods of evolution operator and tight-binding Hamiltonian. Operating mechanism of the designed FETs is also presented with projected local density of states and band diagrams.

Three-dimensional graphdiyne as a topological nodal-line semimetal

NASA Astrophysics Data System (ADS)

Nomura, Takafumi; Habe, Tetsuro; Sakamoto, Ryota; Koshino, Mikito

2018-05-01

We study the electronic band structure of three-dimensional ABC-stacked (rhombohedral) graphdiyne, which is a new planar carbon allotrope recently fabricated. Using first-principles calculation, we show that the system is a nodal-line semimetal, in which the conduction band and valence band cross at a closed ring in the momentum space. We derive the minimum tight-binding model and the low-energy effective Hamiltonian in a 4 ×4 matrix form. The nodal line is protected by a nontrivial winding number, and it ensures the existence of the topological surface state in a finite-thickness slab. The Fermi surface of the doped system exhibits a peculiar, self-intersecting hourglass structure, which is quite different from the torus or pipe shape in the previously proposed nodal semimetals. Despite its simple configuration, three-dimensional graphdiyne offers unique electronic properties distinct from any other carbon allotropes.

Optimized Projection Matrix for Compressive Sensing

NASA Astrophysics Data System (ADS)

Xu, Jianping; Pi, Yiming; Cao, Zongjie

2010-12-01

Compressive sensing (CS) is mainly concerned with low-coherence pairs, since the number of samples needed to recover the signal is proportional to the mutual coherence between projection matrix and sparsifying matrix. Until now, papers on CS always assume the projection matrix to be a random matrix. In this paper, aiming at minimizing the mutual coherence, a method is proposed to optimize the projection matrix. This method is based on equiangular tight frame (ETF) design because an ETF has minimum coherence. It is impossible to solve the problem exactly because of the complexity. Therefore, an alternating minimization type method is used to find a feasible solution. The optimally designed projection matrix can further reduce the necessary number of samples for recovery or improve the recovery accuracy. The proposed method demonstrates better performance than conventional optimization methods, which brings benefits to both basis pursuit and orthogonal matching pursuit.

Modeling chain folding in protein-constrained circular DNA.

PubMed Central

Martino, J A; Olson, W K

1998-01-01

An efficient method for sampling equilibrium configurations of DNA chains binding one or more DNA-bending proteins is presented. The technique is applied to obtain the tertiary structures of minimal bending energy for a selection of dinucleosomal minichromosomes that differ in degree of protein-DNA interaction, protein spacing along the DNA chain contour, and ring size. The protein-bound portions of the DNA chains are represented by tight, left-handed supercoils of fixed geometry. The protein-free regions are modeled individually as elastic rods. For each random spatial arrangement of the two nucleosomes assumed during a stochastic search for the global minimum, the paths of the flexible connecting DNA segments are determined through a numerical solution of the equations of equilibrium for torsionally relaxed elastic rods. The minimal energy forms reveal how protein binding and spacing and plasmid size differentially affect folding and offer new insights into experimental minichromosome systems. PMID:9591675

Calcium Channels and Oxidative Stress Mediate a Synergistic Disruption of Tight Junctions by Ethanol and Acetaldehyde in Caco-2 Cell Monolayers.

PubMed

Samak, Geetha; Gangwar, Ruchika; Meena, Avtar S; Rao, Roshan G; Shukla, Pradeep K; Manda, Bhargavi; Narayanan, Damodaran; Jaggar, Jonathan H; Rao, RadhaKrishna

2016-12-13

Ethanol is metabolized into acetaldehyde in most tissues. In this study, we investigated the synergistic effect of ethanol and acetaldehyde on the tight junction integrity in Caco-2 cell monolayers. Expression of alcohol dehydrogenase sensitized Caco-2 cells to ethanol-induced tight junction disruption and barrier dysfunction, whereas aldehyde dehydrogenase attenuated acetaldehyde-induced tight junction disruption. Ethanol up to 150 mM did not affect tight junction integrity or barrier function, but it dose-dependently increased acetaldehyde-mediated tight junction disruption and barrier dysfunction. Src kinase and MLCK inhibitors blocked this synergistic effect of ethanol and acetaldehyde on tight junction. Ethanol and acetaldehyde caused a rapid and synergistic elevation of intracellular calcium. Calcium depletion by BAPTA or Ca 2+ -free medium blocked ethanol and acetaldehyde-induced barrier dysfunction and tight junction disruption. Diltiazem and selective knockdown of TRPV6 or Ca V 1.3 channels, by shRNA blocked ethanol and acetaldehyde-induced tight junction disruption and barrier dysfunction. Ethanol and acetaldehyde induced a rapid and synergistic increase in reactive oxygen species by a calcium-dependent mechanism. N-acetyl-L-cysteine and cyclosporine A, blocked ethanol and acetaldehyde-induced barrier dysfunction and tight junction disruption. These results demonstrate that ethanol and acetaldehyde synergistically disrupt tight junctions by a mechanism involving calcium, oxidative stress, Src kinase and MLCK.

49 CFR 178.45 - Specification 3T seamless steel cylinder.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., and service pressure. A DOT 3T cylinder is a seamless steel cylinder with a minimum water capacity of...) Wall thickness. The minimum wall thickness must be such that the wall stress at the minimum specified... the physical tests required in paragraphs (j) and (k) of this section. A wall stress of more than 90...

40 CFR 63.1257 - Test methods and compliance procedures.

Code of Federal Regulations, 2012 CFR

2012-07-01

...)(2), or 63.1256(h)(2)(i)(C) with a minimum residence time of 0.5 seconds and a minimum temperature of... temperature of the organic HAP, must consider the vent stream flow rate, and must establish the design minimum and average temperature in the combustion zone and the combustion zone residence time. (B) For a...

40 CFR 63.1257 - Test methods and compliance procedures.

Code of Federal Regulations, 2011 CFR

2011-07-01

...)(2), or 63.1256(h)(2)(i)(C) with a minimum residence time of 0.5 seconds and a minimum temperature of... temperature of the organic HAP, must consider the vent stream flow rate, and must establish the design minimum and average temperature in the combustion zone and the combustion zone residence time. (B) For a...

40 CFR 63.1257 - Test methods and compliance procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

...)(2), or 63.1256(h)(2)(i)(C) with a minimum residence time of 0.5 seconds and a minimum temperature of... temperature of the organic HAP, must consider the vent stream flow rate, and must establish the design minimum and average temperature in the combustion zone and the combustion zone residence time. (B) For a...

Tight control of mild-moderate pre-existing or non-proteinuric gestational hypertension.

PubMed

Nabhan, Ashraf F; Elsedawy, Maged M

2011-07-06

The question of the target blood pressure in pregnant women with mild-moderate hypertension continues to be an area of debate. To compare tight versus very tight control of mild-moderate pre-existing or non-proteinuric gestational hypertension for improving outcomes We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 March 2011), CENTRAL (The Cochrane Library 2011, Issue 3), MEDLINE (January 1966 to March 2011), and the metaRegister of Controlled Trials (31 March 2011). We handsearched citation lists of relevant publications, review articles, and included studies. Randomized controlled trials of tight versus very tight control in pregnant women with mild or moderate pre-existing or non-proteinuric gestational hypertension. Two authors independently assessed trial quality and extracted data. We expressed results as risk ratio (RR) or mean differences, together with their 95% confidence intervals (CI). We included two studies (256 participants) with mild-moderate pre-existing or non-proteinuric gestational hypertension. There was no evidence of a difference between tight and very tight control groups regarding severe pre-eclampsia (risk ratio (RR) 1.28, 95% CI 0.97 to 1.70; two trials, 256 participants). More women in the tight group were hospitalized during their pregnancy (RR 2.53, 95% CI 1.14 to 5.63; one trial, 125 participants). There was no evidence of a difference in other outcome measures including fetal distress, IUGR, neonatal admission to a NICU, perinatal deaths, induction of labor and cesarean delivery between the tight and the very tight control groups. Gestational age at delivery had a non-significant mean difference (MD) of -0.15 weeks between the tight and very tight control groups (MD -0.15, 95% CI -1.52 to 1.21, random-effects, T² = 0.75, I² = 77%; two trials, 256 participants). The MD in birthweight between the tight and the very tight control group was not significant (MD -100.00 grams, 95% CI -363.69 to 163.69; one trial, 125 participants). For pregnant women with non-severe pre-existing or non-proteinuric gestational hypertension, there is insufficient evidence to determine how tight control of hypertension should be achieved to improve maternal and fetal-neonatal outcomes.

A hybrid data fusion method for GNSS/INS integration navigation system

NASA Astrophysics Data System (ADS)

Yang, Ling; Li, Bofeng; Shen, Yunzhong; Li, Haojun

2017-04-01

Although DGNSS is widely used and PPP-GNSS is nowadays a viable precise positioning technology option, the major disadvantage of GNSS still remains: signal blockage due to obstructions in urban and built up environments, and extreme power attenuation of the signals when operated indoors. The combination of GNSS with other sensors, such as a self-contained inertial navigation system (INS), provides an ideal position and attitude determination solution which can not only mitigate the weakness of GNSS, but also bound the INS error that otherwise would grow with time when the INS operates alone. However, the navigation accuracy provided by GNSS/INS strongly depends on the quality and geometry of the GNSS observations, the quality of the INS technology used, and the integration model applied. There are two main types of coupled schemes for integration systems: loosely coupled integration and tightly coupled integration. In loosely coupled integration, position measurements are taken from both systems and combined optimally, usually in a Kalman filter. Tightly coupled integration directly combines the raw pseudorange or carrier phase measurements of GNSS with inertial measurements in an extended Kalman filter. The latter technique improves the ability to resolve ambiguities, i.e. allows a quicker recovery from outage events such as a loss of signal under vegetation. In recent years, tightly coupled differential carrier phase GNSS/INS integration has become popular, because it has the advantage of providing accurate position information even when GPS measurements are rank-deficient in stand-alone processing and is theoretically optimal in a filtering sense, especially in urban navigation applications. However, the heavier computational burden and sensor communication usually complicate the tightly coupled integration and reduce the system efficiency, compared with the loosely coupled integration. In this paper, it has been proved that the loosely coupled and tightly coupled algorithms are equivalent when following conditions are satisfied: 1) there is enough redundancy on the GNSS raw measurements; 2) only pseudorange measurements are used; 3) If differential carrier phase measurements are used, only the float solutions of the ambiguities are considered; 4) the covariance of the loosely coupled measurement model should come from the GNSS standalone solution instead of conventional pre-determined values. Based on the equivalence proof, a dual-step loosely coupled procedure is proposed to regenerate the equal ambiguity fixing solutions in tightly coupled procedure. Accordingly, the tightly coupled differential carrier phase or pseudorange GNSS/INS integration can be simplified, which will degrade to an equivalent loosely coupled integration when there are enough measurement redundancy and recover to a tightly coupled integration when GNSS measurements are rank-deficient. By this hybrid data fusion method, both the optimality of the tightly coupled algorithm and the efficiency of the loosely coupled algorithm can be conserved. Field test results confirm the effectiveness of the proposed method.

Claudin 5 Expression in Mouse Seminiferous Epithelium Is Dependent upon the Transcription Factor Ets Variant 5 and Contributes to Blood-Testis Barrier Function1

PubMed Central

Morrow, Carla M.K.; Tyagi, Gaurav; Simon, Liz; Carnes, Kay; Murphy, Kenneth M.; Cooke, Paul S.; Hofmann, Marie-Claude C.; Hess, Rex A.

2009-01-01

The blood-testis barrier (BTB) is formed by tight junctions between Sertoli cells. Results of previous studies suggested that the barrier is deficient in ets variant 5 (ETV5) gene-deleted mice; therefore, microarray data were examined for changes in tight junction-associated genes. The tight junctional protein claudin 5 (CLDN5) was decreased in testes of 8-day-old Etv5−/− pups. The study reported herein examined the expression of CLDN5 in wild-type (WT) and Etv5−/− mice and evaluated its contribution to BTB function. CLDN5 protein expression was evaluated in 8-day-old WT and Etv5−/− and adult WT, Etv5−/−, and W/Wv testes by immunohistochemistry and in 8-day-old WT Sertoli cell-enriched and germ cell-enriched fractions by immunocytochemistry. Cldn5 mRNA expression was evaluated in 0- to 20-day-old and adult WT mice and in 8-day-old and adult Etv5−/− mice via quantitative PCR. Tracer studies were performed in adult WT, Etv5−/−, and W/Wv mice. The results indicate the following: 1) CLDN5 was expressed in Sertoli cells, spermatogonia, and preleptotene spermatocytes. 2) Seminiferous epithelial CLDN5 expression depended upon both the presence of germ cells and ETV5. 3) CLDN5 expression in testicular vascular endothelium and rete testis epithelium was ETV5 independent. 4) Cldn5 mRNA expression increased in the testes of juvenile mice at the time of BTB formation. 5) Testes of Etv5−/− and W/Wv mice, which are both deficient in seminiferous epithelial CLDN5 expression, had biotin tracer leakage from the interstitial space into the seminiferous tubule lumen. In conclusion, CLDN5 is expressed in the seminiferous epithelium, appears to be regulated by multiple influences, and contributes to BTB function. PMID:19571261

Schistosoma japonicum ova maintains epithelial barrier function during experimental colitis.

PubMed

Xia, Chen-Mei; Zhao, Yuan; Jiang, Li; Jiang, Jie; Zhang, Shun-Cai

2011-11-21

To evaluate the impacts of Schistosoma japonicum (S. japonicum) ova on the tight junction barriers in a trinitrobenzenesulfonic acid (TNBS)-induced colitis model. Balb/c mice were randomly divided into three groups: control group; TNBS(+)ova(-) group and TNBS(+)ova(+) group. TNBS was used intracolonic to induce colitis and mice of the TNBS(+)ova(+) group were pre-exposed to S. japonicum ova as a prophylactic intervention. Colon inflammation was quantified using following variables: mouse mortality, weight loss, colon extent and microscopic inflammation score. Serum expression of tumor necrosis factor-α and interferon-γ were assessed to evaluate the systemic inflammatory response. NOD2 and its mRNA were also tested. Bacterial translocations were tested by culturing blood and several tissues. ZO-1 and occludin were chosen as the representations of tight junction proteins. Both the proteins and mRNA were assessed. Ova pre-treatment contributed to the relief of colitis and decreased the mortality of the models. NOD2 expression was significantly downregulated when pretreated with the ova. The TNBS injection caused a significant downregulation of ZO-1 and occludin mRNA together with their proteins in the colon; ova pre-exposure reversed these alterations. Treatment with S. japonicum ova in the colitis model caused lower intestinal bacterial translocation frequency. S. japonicum ova can maintain epithelial barrier function through increasing tight junction proteins, thus causing less exposure of NOD2 to the luminal antigens which may activate a series of inflammatory factors and induce colitis.

Reversible Opening of Intercellular Junctions of Intestinal Epithelial and Brain Endothelial Cells With Tight Junction Modulator Peptides.

PubMed

Bocsik, Alexandra; Walter, Fruzsina R; Gyebrovszki, Andrea; Fülöp, Lívia; Blasig, Ingolf; Dabrowski, Sebastian; Ötvös, Ferenc; Tóth, András; Rákhely, Gábor; Veszelka, Szilvia; Vastag, Monika; Szabó-Révész, Piroska; Deli, Mária A

2016-02-01

The intercellular junctions restrict the free passage of hydrophilic compounds through the paracellular clefts. Reversible opening of the tight junctions of biological barriers is investigated as one of the ways to increase drug delivery to the systemic circulation or the central nervous system. Six peptides, ADT-6, HAV-6, C-CPE, 7-mer (FDFWITP, PN-78), AT-1002, and PN-159, acting on different integral membrane and linker junctional proteins were tested on Caco-2 intestinal epithelial cell line and a coculture model of the blood-brain barrier. All peptides tested in nontoxic concentrations showed a reversible tight junctions modulating effect and were effective to open the paracellular pathway for the marker molecules fluorescein and albumin. The change in the structure of cell-cell junctions was verified by immunostaining for occludin, claudin-4,-5, ZO-1, β-catenin, and E-cadherin. Expression levels of occludin and claudins were measured in both models. We could demonstrate a selectivity of C-CPE, ADT-6, and HAV-6 peptides for epithelial cells and 7-mer and AT-1002 peptides for brain endothelial cells. PN-159 was the most effective modulator of junctional permeability in both models possibly acting via claudin-1 and -5. Our results indicate that these peptides can be effectively and selectively used as potential pharmaceutical excipients to improve drug delivery across biological barriers. Copyright © 2016 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Smooth affine shear tight frames: digitization and applications

NASA Astrophysics Data System (ADS)

Zhuang, Xiaosheng

2015-08-01

In this paper, we mainly discuss one of the recent developed directional multiscale representation systems: smooth affine shear tight frames. A directional wavelet tight frame is generated by isotropic dilations and translations of directional wavelet generators, while an affine shear tight frame is generated by anisotropic dilations, shears, and translations of shearlet generators. These two tight frames are actually connected in the sense that the affine shear tight frame can be obtained from a directional wavelet tight frame through subsampling. Consequently, an affine shear tight frame indeed has an underlying filter bank from the MRA structure of its associated directional wavelet tight frame. We call such filter banks affine shear filter banks, which can be designed completely in the frequency domain. We discuss the digitization of affine shear filter banks and their implementations: the forward and backward digital affine shear transforms. Redundancy rate and computational complexity of digital affine shear transforms are also investigated in this paper. Numerical experiments and comparisons in image/video processing show the advantages of digital affine shear transforms over many other state-of-art directional multiscale representation systems.

Mechanical and Physical Properties of ASTM C33 Sand

DTIC Science & Technology

2008-02-01

ERDC/GSL TR-08-2 7 Grain-size Distribution (1) (ASTM D 422) 1 test run on total sand sample Proctor Density Curves (2) (ASTM D 698 and D... Proctor (Figure 4). Because of the noncohesive nature of the SP material, a series of relative density tests measuring both minimum and maximum... density tests were conducted with moisture added to the sand. A summary of the minimum and maximum densities is given in Table 2. During Proctor

An Evaluation of the Sniffer Global Optimization Algorithm Using Standard Test Functions

NASA Astrophysics Data System (ADS)

Butler, Roger A. R.; Slaminka, Edward E.

1992-03-01

The performance of Sniffer—a new global optimization algorithm—is compared with that of Simulated Annealing. Using the number of function evaluations as a measure of efficiency, the new algorithm is shown to be significantly better at finding the global minimum of seven standard test functions. Several of the test functions used have many local minima and very steep walls surrounding the global minimum. Such functions are intended to thwart global minimization algorithms.

The relation between peak response magnitudes and agreement in diagnoses obtained from two different phallometric tests for pedophilia.

PubMed

Lykins, Amy D; Cantor, James M; Kuban, Michael E; Blak, Thomas; Dickey, Robert; Klassen, Philip E; Blanchard, Ray

2010-03-01

Phallometric testing is widely considered the best psychophysiological procedure for assessing erotic preferences in men. Researchers have differed, however, on the necessity of setting some minimum criterion of penile response for ascertaining the interpretability of a phallometric test result. Proponents of a minimum criterion have generally based their view on the intuitive notion that "more is better" rather than any formal demonstration of this. The present study was conducted to investigate whether there is any empirical evidence for this intuitive notion, by examining the relation between magnitude of penile response and the agreement in diagnoses obtained in two test sessions using different laboratory stimuli. The results showed that examinees with inconsistent diagnoses responded less on both tests and that examinees with inconsistent diagnoses responded less on the second test after controlling for their response on the first test. Results also indicated that at response levels less than 1 cm(3), diagnostic consistency was no better than chance, supporting the establishment of a minimum response level criterion.

Assessing Intellectual Ability with a Minimum of Cultural Bias for Two Samples of Metis and Indian Children.

ERIC Educational Resources Information Center

West, Lloyd Wilbert

An investigation was designed to ascertain the effects of cultural background on selected intelligence tests and to identify instruments which validly measure intellectual ability with a minimum of cultural bias. A battery of tests, selected for factor analytic study, was administered and replicated at four grade levels to a sample of Metis and…

40 CFR Table 1 to Subpart Cccc of... - Emission Limitations

Code of Federal Regulations, 2011 CFR

2011-07-01

... per dry standard cubic meter 3-run average (1 hour minimum sample time per run) Performance test (Method 29 of appendix A of this part). Carbon monoxide 157 parts per million by dry volume 3-run average (1 hour minimum sample time per run) Performance test (Method 10, 10A, or 10B of appendix A of this...

42 CFR 84.153 - Airflow resistance test, Type A and Type AE supplied-air respirators; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 89 300 91 4.0 102 (c) The exhalation resistance shall not exceed 25 mm. (1 inch) of water-column... 42 Public Health 1 2010-10-01 2010-10-01 false Airflow resistance test, Type A and Type AE supplied-air respirators; minimum requirements. 84.153 Section 84.153 Public Health PUBLIC HEALTH SERVICE...

40 CFR Table 1 to Subpart Cccc of... - Emission Limitations

Code of Federal Regulations, 2010 CFR

2010-07-01

... per dry standard cubic meter 3-run average (1 hour minimum sample time per run) Performance test (Method 29 of appendix A of this part). Carbon monoxide 157 parts per million by dry volume 3-run average (1 hour minimum sample time per run) Performance test (Method 10, 10A, or 10B of appendix A of this...

40 CFR Table 2 to Subpart Dddd of... - Model Rule-Emission Limitations

Code of Federal Regulations, 2010 CFR

2010-07-01

... meter 3-run average (1 hour minimum sample time per run) Performance test (Method 29 of appendix A of this part) Carbon monoxide 157 parts per million by dry volume 3-run average (1 hour minimum sample time per run) Performance test (Method 10, 10A, or 10B, of appendix A of this part) Dioxins/furans...

Highly cited German research contributions to the fields of radiation oncology, biology, and physics: focus on collaboration and diversity.

PubMed

Nieder, C

2012-10-01

Tight budgets and increasing competition for research funding pose challenges for highly specialized medical disciplines such as radiation oncology. Therefore, a systematic review was performed of successfully completed research that had a high impact on clinical practice. These data might be helpful when preparing new projects. Different measures of impact, visibility, and quality of published research are available, each with its own pros and cons. For this study, the article citation rate was chosen (minimum 15 citations per year on average). Highly cited German contributions to the fields of radiation oncology, biology, and physics (published between 1990 and 2010) were identified from the Scopus database. Between 1990 and 2010, 106 articles published in 44 scientific journals met the citation requirement. The median average of yearly citations was 21 (maximum 167, minimum 15). All articles with ≥ 40 citations per year were published between 2003 and 2009, consistent with the assumption that the citation rate gradually increases for up to 2 years after publication. Most citations per year were recorded for meta-analyses and randomized phase III trials, which typically were performed by collaborative groups. A large variety of clinical radiotherapy, biology, and physics topics achieved high numbers of citations. However, areas such as quality of life and side effects, palliative radiotherapy, and radiotherapy for nonmalignant disorders were underrepresented. Efforts to increase their visibility might be warranted.

Air Force Dynamic Mechanical Analysis of NATO Round Robin Propellant Testing for Development of AOP-4717

DTIC Science & Technology

2015-09-23

Round Robin Propellant Testing for Development of AOP-4717 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S...area code) N/A Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std. 239.18 0 Air Force Dynamic Mechanical Analysis of NATO Round Robin ...the clamps are tight at the coldest temperature. • Long tests such as the frequency sweep sequences prescribed in this round robin may be

HIV-1 gp120 Glycoprotein Interacting with Dendritic Cell-specific Intercellular Adhesion Molecule 3-grabbing Non-integrin (DC-SIGN) Down-Regulates Tight Junction Proteins to Disrupt the Blood Retinal Barrier and Increase Its Permeability.

PubMed

Qian, Yi-Wen; Li, Chuan; Jiang, Ai-Ping; Ge, Shengfang; Gu, Ping; Fan, Xianqun; Li, Tai-Sheng; Jin, Xia; Wang, Jian-Hua; Wang, Zhi-Liang

2016-10-28

Approximately 70% of HIV-1 infected patients acquire ocular opportunistic infections and manifest eye disorders during the course of their illness. The mechanisms by which pathogens invade the ocular site, however, are unclear. Under normal circumstances, vascular endothelium and retinal pigment epithelium (RPE), which possess a well developed tight junction complex, form the blood-retinal barrier (BRB) to prevent pathogen invasion. We hypothesize that disruption of the BRB allows pathogen entry into ocular sites. The hypothesis was tested using in vitro models. We discovered that human RPE cells could bind to either HIV-1 gp120 glycoproteins or HIV-1 viral particles. Furthermore, the binding was mediated by dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) expressed on RPE cells. Upon gp120 binding to DC-SIGN, cellular NF-κB signaling was triggered, leading to the induction of matrix metalloproteinases, which subsequently degraded tight junction proteins and disrupted the BRB integrity. DC-SIGN knockdown or prior blocking with a specific antibody abolished gp120-induced matrix metalloproteinase expression and reduced the degradation of tight junction proteins. This study elucidates a novel mechanism by which HIV, type 1 invades ocular tissues and provides additional insights into the translocation or invasion process of ocular complication-associated pathogens. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

A Comparative Study of the Employee Skills/Training Acceptable to Employers Under Varying Degrees of Labor Market Stringencies. Final Report.

ERIC Educational Resources Information Center

Fisher, W. Halder; And Others

The purposes of this stud y were to test the dependability of stated employee selection criteria, to ascertain the degree of congruence between stated and actual selection criteria, and to determine the degree of change in criteria due to "looseness" or "tightness" of the local labor market. Seven test labor market areas representing a variety of…

THE NORTH AMERICAN MERCURY MODEL INTER-COMPARISON STUDY (NAMMIS)

EPA Science Inventory

This paper describes the North American Mercury Model Inter-comparison Study (NAMMIS). The NAMMIS is an effort to apply atmospheric Hg models in a tightly constrained testing environment with a focus on North America. With each model using the same input data sets for initial co...

A quantitative adverse outcome pathway model for thyroid axis disruption in Xenopus laevis tadpoles

EPA Science Inventory

The development of Xenopus laevis tadpoles is tightly controlled by the thyroid hormones tetraiodothyronine (T4) and triiodothyronine (T3). Toxicity testing efforts have shown that several compounds interfere with development in X. laevis tadpoles by disrupting the thyroid axis a...

VOLUMETRIC LEAK DETECTION IN LARGE UNDERGROUND STORAGE TANKS - VOLUME I

EPA Science Inventory

A set of experiments was conducted to determine whether volumetric leak detection system presently used to test underground storage tanks (USTs) up to 38,000 L (10,000 gal) in capacity could meet EPA's regulatory standards for tank tightness and automatic tank gauging systems whe...

Tightness Entropic Uncertainty Relation in Quantum Markovian-Davies Environment

NASA Astrophysics Data System (ADS)

Zhang, Jun; Liu, Liang; Han, Yan

2018-05-01

In this paper, we investigate the tightness of entropic uncertainty relation in the absence (presence) of the quantum memory which the memory particle being weakly coupled to a decohering Davies-type Markovian environment. The results show that the tightness of the quantum uncertainty relation can be controlled by the energy relaxation time F, the dephasing time G and the rescaled temperature p, the perfect tightness can be arrived by dephasing and energy relaxation satisfying F = 2G and p = 1/2. In addition, the tightness of the memory-assisted entropic uncertainty relation and the entropic uncertainty relation can be influenced mainly by the purity. While in memory-assisted model, the purity and quantum correlation can also influence the tightness actively while the quantum entanglement can influence the tightness slightly.

Test and evaluation of the Navy half-watt RTG. [Radioisotope Thermoelectric Generator

NASA Technical Reports Server (NTRS)

Rosell, F. E., Jr.; Lane, S. D.; Eggers, P. E.; Gawthrop, W. E.; Rouklove, P. G.; Truscello, V. C.

1976-01-01

The radioisotope thermoelectric generator (RTG) considered is to provide a continuous minimum power output of 0.5 watt at 6.0 to 8.5 volts for a minimum period of 15 years. The mechanical-electrical evaluation phase discussed involved the conduction of shock and vibration tests. The thermochemical-physical evaluation phase consisted of an analysis of the materials and the development of a thermal model. The thermoelectric evaluation phase included the accelerated testing of the thermoelectric modules.

GEOLOGIC ASPECTS OF TIGHT GAS RESERVOIRS IN THE ROCKY MOUNTAIN REGION.

USGS Publications Warehouse

Spencer, Charles W.

1985-01-01

The authors describe some geologic characteristics of tight gas reservoirs in the Rocky Mountain region. These reservoirs usually have an in-situ permeability to gas of 0. 1 md or less and can be classified into four general geologic and engineering categories: (1) marginal marine blanket, (2) lenticular, (3) chalk, and (4) marine blanket shallow. Microscopic study of pore/permeability relationships indicates the existence of two varieties of tight reservoirs. One variety is tight because of the fine grain size of the rock. The second variety is tight because the rock is relatively tightly cemented and the pores are poorly connected by small pore throats and capillaries.

Ferromagnetic core valve gives rapid action on minimum energy

NASA Technical Reports Server (NTRS)

Larson, A. V.; Tinkham, J. P.

1967-01-01

Miniature solenoid valve controls propellant flow during tests on a coaxial plasma accelerator. It uses an advanced ferromagnetic core design which meets all the rapid-acting requirements with a minimum of input energy.

Anti-aging Friction of Carbonate Fault Mirror and its Microstructural Interpretation

NASA Astrophysics Data System (ADS)

Park, Y.; Ree, J. H.; Hirose, T.

2017-12-01

In our slide-hold-slide (SHS) friction tests on carbonate fault rocks, fault mirror (FM), light reflective mirror-like fault surface, shows almost zero or slightly negative aging rate of friction (`anti-aging' friction), whereas carbonate faults without FM exhibit a positive aging rate. We analyzed microstructures from three types of carbonate faults to explore the cause of the anti-aging friction of FM. The three types of fault rocks before SHS tests were made from Carrara marble; (i) FM, (ii) crushed gouge of former FM (CF), and (iii) gouge produced by pre-shearing of Carrara marble (PR). The fault zone of FM before SHS tests consists of sintered nanograin patches smeared into negative asperities of wall rocks (thickness up to 150 μm) and a sintered gouge layer between wall rocks (thickness up to 200 μm) that is composed of tightly-packed nanograins (50-500 nm in size) with triple junctions and angular-subangular fragments (a few-100 μm) of sintered nanograin aggregates. A straight and discrete Y-shear surface defines a boundary between the gouge layer and the nanograin patches or between the layer and wall rock. CF specimens before SHS tests are composed of patches of sintered nanograins as in FM specimens and a porous gouge layer with finer nanograins (a few-20 nm in size) and angular fragments of former FM. PR specimens before SHS tests are composed of damaged wall rocks and porous gouge with finer nanograins (a few-tens of μm). After SHS tests, sintered appearance of grains within the fault zones of CF and PR indicates the increase in interparticle bonding and also in contact area by grain aggregation. In contrast, the gouge layer of FM specimens after SHS tests consists mostly of angular fragments of sintered nanograin aggregates. The angular shape of the fragments indicates little increase in bonding and contact area between the fragments. Tightly sintered nanograins in FM specimens would have a lower chemical reactivity with their size coarser and sintering stronger than those of CF and PR. Furthermore, a high wear resistance of sintered nanograins of FM would prohibit generation of fine wear debris which may have led to the strenghtened interparticle bonding. Our results imply that anti-aging friction may be a common behavior other rocks' FM too, once they are composed of tightly sintered nanograins.

Preliminary supersonic flight test evaluation of performance seeking control

NASA Technical Reports Server (NTRS)

Orme, John S.; Gilyard, Glenn B.

1993-01-01

Digital flight and engine control, powerful onboard computers, and sophisticated controls techniques may improve aircraft performance by maximizing fuel efficiency, maximizing thrust, and extending engine life. An adaptive performance seeking control system for optimizing the quasi-steady state performance of an F-15 aircraft was developed and flight tested. This system has three optimization modes: minimum fuel, maximum thrust, and minimum fan turbine inlet temperature. Tests of the minimum fuel and fan turbine inlet temperature modes were performed at a constant thrust. Supersonic single-engine flight tests of the three modes were conducted using varied after burning power settings. At supersonic conditions, the performance seeking control law optimizes the integrated airframe, inlet, and engine. At subsonic conditions, only the engine is optimized. Supersonic flight tests showed improvements in thrust of 9 percent, increases in fuel savings of 8 percent, and reductions of up to 85 deg R in turbine temperatures for all three modes. The supersonic performance seeking control structure is described and preliminary results of supersonic performance seeking control tests are given. These findings have implications for improving performance of civilian and military aircraft.

46 CFR 169.827 - Hatches and other openings.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 7 2012-10-01 2012-10-01 false Hatches and other openings. 169.827 Section 169.827... Operations Tests, Drills, and Inspections § 169.827 Hatches and other openings. The master is responsible for seeing that all hatches, openings in the hull, and watertight doors are properly closed tight. ...

46 CFR 169.827 - Hatches and other openings.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 7 2011-10-01 2011-10-01 false Hatches and other openings. 169.827 Section 169.827... Operations Tests, Drills, and Inspections § 169.827 Hatches and other openings. The master is responsible for seeing that all hatches, openings in the hull, and watertight doors are properly closed tight. ...

46 CFR 169.827 - Hatches and other openings.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 7 2014-10-01 2014-10-01 false Hatches and other openings. 169.827 Section 169.827... Operations Tests, Drills, and Inspections § 169.827 Hatches and other openings. The master is responsible for seeing that all hatches, openings in the hull, and watertight doors are properly closed tight. ...

46 CFR 169.827 - Hatches and other openings.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 7 2013-10-01 2013-10-01 false Hatches and other openings. 169.827 Section 169.827... Operations Tests, Drills, and Inspections § 169.827 Hatches and other openings. The master is responsible for seeing that all hatches, openings in the hull, and watertight doors are properly closed tight. ...

46 CFR 169.827 - Hatches and other openings.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Hatches and other openings. 169.827 Section 169.827... Operations Tests, Drills, and Inspections § 169.827 Hatches and other openings. The master is responsible for seeing that all hatches, openings in the hull, and watertight doors are properly closed tight. ...

Implementing Active Homework in Secondary Physical Education

ERIC Educational Resources Information Center

St. Ours, Elizabeth; Scrabis-Fletcher, Kristin A.

2013-01-01

During the past decade, physical education has gone through some tough times. Between increased pressures to succeed on standardized testing, which has resulted in increased classroom time and decreased time in the gym, and tight budgets, children are not getting the quality physical education they deserve. The "2012 Shape of the Nation…

A Simulated Journey

ERIC Educational Resources Information Center

Yoder, Lisa

2006-01-01

Students learn best when they interact with new information on a personal level. It is a challenge for teachers to tightly align student experiences with the standards assessed on high-stakes tests. To achieve this goal in social studies, the author has turned increasingly to simulations where students find such activities engaging, and their…

40 CFR 86.1207-96 - Sampling and analytical systems; evaporative emissions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... (CONTINUED) Evaporative Emission Test Procedures for New Gasoline-Fueled, Natural Gas-Fueled, Liquefied Petroleum Gas-Fueled and Methanol-Fueled Heavy-Duty Vehicles § 86.1207-96 Sampling and analytical systems..., the enclosure shall be gas tight in accordance with § 86.1217-96. Interior surfaces must be...

40 CFR 86.1207-96 - Sampling and analytical systems; evaporative emissions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CONTINUED) Evaporative Emission Test Procedures for New Gasoline-Fueled, Natural Gas-Fueled, Liquefied Petroleum Gas-Fueled and Methanol-Fueled Heavy-Duty Vehicles § 86.1207-96 Sampling and analytical systems..., the enclosure shall be gas tight in accordance with § 86.1217-96. Interior surfaces must be...

Two Successful Variations of Motivational Contests: Bridges and "Whizzers."

ERIC Educational Resources Information Center

Koser, John F.

1985-01-01

Describes two contests in which students: (1) build bridges from balsa wood; or (2) construct whizzers (self-contained motorized devices for movement on tight steel wires). Testing situations and guidelines for these contests are included. Points out that physics enrollments have increased as a result of the contests. (DH)

Pinedale unit MHF experiments. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1976-10-01

Three MHF experiments have been performed in a tight reservoir in the Northern Green River Basin at depths between 8,000 and 12,000 feet. A total of 894,190 gallons of fluid and 2,715,000 pounds of sand were pumped in three stages in two wells with the limited entry technique. Fluid viscosities were designed to give propped lengths of 1,000 to 1,500 feet and proppant sand beds having heights greater than 50 percent of the thickness of each sandstone fractured. The experiments included laboratory research to design limited entry with perforations through one and two strings of casing. Field data analysis tomore » determine fracture gradients and extent of perforation erosion has been complicated by a dependence of friction pressure in tubular goods upon sand concentration and by an apparent large variation in minimum principal in-situ stress between sandstones simultaneously fractured with the limited entry technique. A high proppant concentration was used to assure that production would be limited to reservoir characteristics, rather than fracture conductivity. Comparison was made with results of prior hydraulic fractures propped with a partial monolayer. Resulting production capacity to date has been only about one-fifth that projected in the National Gas Survey report. Evaluation of the resulting production capability and the cost of the hydraulic fracture treatmnet indicates that the stimulation technique employed is not commercially feasible at this time for the reservoir conditions tested. 10 fig, 6 tables.« less

Evaluation of an Active Clearance Control System Concept

NASA Technical Reports Server (NTRS)

Steinetz, Bruce M.; Lattime, Scott B.; DeCastro, Jonathan A.; Oswald, Jay; Melcher, Kevin J.

2005-01-01

Reducing blade tip clearances through active tip clearance control in the high pressure turbine can lead to significant reductions in emissions and specific fuel consumption as well as dramatic improvements in operating efficiency and increased service life. Current engines employ scheduled cooling of the outer case flanges to reduce high pressure turbine tip clearances during cruise conditions. These systems have relatively slow response and do not use clearance measurement, thereby forcing cold build clearances to set the minimum clearances at extreme operating conditions (e.g., takeoff, reburst) and not allowing cruise clearances to be minimized due to the possibility of throttle transients (e.g., step change in altitude). In an effort to improve upon current thermal methods, a first generation mechanically-actuated active clearance control (ACC) system has been designed and fabricated. The system utilizes independent actuators, a segmented shroud structure, and clearance measurement feedback to provide fast and precise active clearance control throughout engine operation. Ambient temperature performance tests of this first generation ACC system assessed individual seal component leakage rates and both static and dynamic overall system leakage rates. The ability of the nine electric stepper motors to control the position of the seal carriers in both open- and closed-loop control modes for single and multiple cycles was investigated. The ability of the system to follow simulated engine clearance transients in closed-loop mode showed the system was able to track clearances to within a tight tolerance (0.001 in. error).

Evaluation of an Active Clearance Control System Concept

NASA Technical Reports Server (NTRS)

Steinetz, Bruce M.; Lattime, Scott B.; Taylor, Shawn; DeCastro, Jonathan A.; Oswald, Jay; Melcher, Kevin J.

2005-01-01

Reducing blade tip clearances through active tip clearance control in the high pressure turbine can lead to significant reductions in emissions and specific fuel consumption as well as dramatic improvements in operating efficiency and increased service life. Current engines employ scheduled cooling of the outer case flanges to reduce high pressure turbine tip clearances during cruise conditions. These systems have relatively slow response and do not use clearance measurement, thereby forcing cold build clearances to set the minimum clearances at extreme operating conditions (e.g., takeoff, reburst) and not allowing cruise clearances to be minimized due to the possibility of throttle transients (e.g., step change in altitude). In an effort to improve upon current thermal methods, a first generation mechanically-actuated active clearance control (ACC) system has been designed and fabricated. The system utilizes independent actuators, a segmented shroud structure, and clearance measurement feedback to provide fast and precise active clearance control throughout engine operation. Ambient temperature performance tests of this first generation ACC system assessed individual seal component leakage rates and both static and dynamic overall system leakage rates. The ability of the nine electric stepper motors to control the position of the seal carriers in both open- and closed-loop control modes for single and multiple cycles was investigated. The ability of the system to follow simulated engine clearance transients in closed-loop mode showed the system was able to track clearances to within a tight tolerance ( 0.001 in. error).

The Lactate Minimum Test: Concept, Methodological Aspects and Insights for Future Investigations in Human and Animal Models

PubMed Central

Messias, Leonardo H. D.; Gobatto, Claudio A.; Beck, Wladimir R.; Manchado-Gobatto, Fúlvia B.

2017-01-01

In 1993, Uwe Tegtbur proposed a useful physiological protocol named the lactate minimum test (LMT). This test consists of three distinct phases. Firstly, subjects must perform high intensity efforts to induce hyperlactatemia (phase 1). Subsequently, 8 min of recovery are allowed for transposition of lactate from myocytes (for instance) to the bloodstream (phase 2). Right after the recovery, subjects are submitted to an incremental test until exhaustion (phase 3). The blood lactate concentration is expected to fall during the first stages of the incremental test and as the intensity increases in subsequent stages, to rise again forming a “U” shaped blood lactate kinetic. The minimum point of this curve, named the lactate minimum intensity (LMI), provides an estimation of the intensity that represents the balance between the appearance and clearance of arterial blood lactate, known as the maximal lactate steady state intensity (iMLSS). Furthermore, in addition to the iMLSS estimation, studies have also determined anaerobic parameters (e.g., peak, mean, and minimum force/power) during phase 1 and also the maximum oxygen consumption in phase 3; therefore, the LMT is considered a robust physiological protocol. Although, encouraging reports have been published in both human and animal models, there are still some controversies regarding three main factors: (1) the influence of methodological aspects on the LMT parameters; (2) LMT effectiveness for monitoring training effects; and (3) the LMI as a valid iMLSS estimator. Therefore, the aim of this review is to provide a balanced discussion between scientific evidence of the aforementioned issues, and insights for future investigations are suggested. In summary, further analyses is necessary to determine whether these factors are worthy, since the LMT is relevant in several contexts of health sciences. PMID:28642717

Minimum target prices for production of direct-acting antivirals and associated diagnostics to combat hepatitis C virus

PubMed Central

van de Ven, Nikolien; Fortunak, Joe; Simmons, Bryony; Ford, Nathan; Cooke, Graham S; Khoo, Saye; Hill, Andrew

2015-01-01

Combinations of direct-acting antivirals (DAAs) can cure hepatitis C virus (HCV) in the majority of treatment-naïve patients. Mass treatment programs to cure HCV in developing countries are only feasible if the costs of treatment and laboratory diagnostics are very low. This analysis aimed to estimate minimum costs of DAA treatment and associated diagnostic monitoring. Clinical trials of HCV DAAs were reviewed to identify combinations with consistently high rates of sustained virological response across hepatitis C genotypes. For each DAA, molecular structures, doses, treatment duration, and components of retrosynthesis were used to estimate costs of large-scale, generic production. Manufacturing costs per gram of DAA were based upon treating at least 5 million patients per year and a 40% margin for formulation. Costs of diagnostic support were estimated based on published minimum prices of genotyping, HCV antigen tests plus full blood count/clinical chemistry tests. Predicted minimum costs for 12-week courses of combination DAAs with the most consistent efficacy results were: US$122 per person for sofosbuvir+daclatasvir; US$152 for sofosbuvir+ribavirin; US$192 for sofosbuvir+ledipasvir; and US$115 for MK-8742+MK-5172. Diagnostic testing costs were estimated at US$90 for genotyping US$34 for two HCV antigen tests and US$22 for two full blood count/clinical chemistry tests. Conclusions: Minimum costs of treatment and diagnostics to cure hepatitis C virus infection were estimated at US$171-360 per person without genotyping or US$261-450 per person with genotyping. These cost estimates assume that existing large-scale treatment programs can be established. (Hepatology 2015;61:1174–1182) PMID:25482139

Minimum target prices for production of direct-acting antivirals and associated diagnostics to combat hepatitis C virus.

PubMed

van de Ven, Nikolien; Fortunak, Joe; Simmons, Bryony; Ford, Nathan; Cooke, Graham S; Khoo, Saye; Hill, Andrew

2015-04-01

Combinations of direct-acting antivirals (DAAs) can cure hepatitis C virus (HCV) in the majority of treatment-naïve patients. Mass treatment programs to cure HCV in developing countries are only feasible if the costs of treatment and laboratory diagnostics are very low. This analysis aimed to estimate minimum costs of DAA treatment and associated diagnostic monitoring. Clinical trials of HCV DAAs were reviewed to identify combinations with consistently high rates of sustained virological response across hepatitis C genotypes. For each DAA, molecular structures, doses, treatment duration, and components of retrosynthesis were used to estimate costs of large-scale, generic production. Manufacturing costs per gram of DAA were based upon treating at least 5 million patients per year and a 40% margin for formulation. Costs of diagnostic support were estimated based on published minimum prices of genotyping, HCV antigen tests plus full blood count/clinical chemistry tests. Predicted minimum costs for 12-week courses of combination DAAs with the most consistent efficacy results were: US$122 per person for sofosbuvir+daclatasvir; US$152 for sofosbuvir+ribavirin; US$192 for sofosbuvir+ledipasvir; and US$115 for MK-8742+MK-5172. Diagnostic testing costs were estimated at US$90 for genotyping US$34 for two HCV antigen tests and US$22 for two full blood count/clinical chemistry tests. Minimum costs of treatment and diagnostics to cure hepatitis C virus infection were estimated at US$171-360 per person without genotyping or US$261-450 per person with genotyping. These cost estimates assume that existing large-scale treatment programs can be established. © 2014 The Authors. Hepatology published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

Minimum Performance on Clinical Tests of Physical Function to Predict Walking 6,000 Steps/Day in Knee Osteoarthritis: An Observational Study.

PubMed

Master, Hiral; Thoma, Louise M; Christiansen, Meredith B; Polakowski, Emily; Schmitt, Laura A; White, Daniel K

2018-07-01

Evidence of physical function difficulties, such as difficulty rising from a chair, may limit daily walking for people with knee osteoarthritis (OA). The purpose of this study was to identify minimum performance thresholds on clinical tests of physical function predictive to walking ≥6,000 steps/day. This benchmark is known to discriminate people with knee OA who develop functional limitation over time from those who do not. Using data from the Osteoarthritis Initiative, we quantified daily walking as average steps/day from an accelerometer (Actigraph GT1M) worn for ≥10 hours/day over 1 week. Physical function was quantified using 3 performance-based clinical tests: 5 times sit-to-stand test, walking speed (tested over 20 meters), and 400-meter walk test. To identify minimum performance thresholds for daily walking, we calculated physical function values corresponding to high specificity (80-95%) to predict walking ≥6,000 steps/day. Among 1,925 participants (mean ± SD age 65.1 ± 9.1 years, mean ± SD body mass index 28.4 ± 4.8 kg/m 2 , and 55% female) with valid accelerometer data, 54.9% walked ≥6,000 steps/day. High specificity thresholds of physical function for walking ≥6,000 steps/day ranged 11.4-14.0 seconds on the 5 times sit-to-stand test, 1.13-1.26 meters/second for walking speed, or 315-349 seconds on the 400-meter walk test. Not meeting these minimum performance thresholds on clinical tests of physical function may indicate inadequate physical ability to walk ≥6,000 steps/day for people with knee OA. Rehabilitation may be indicated to address underlying impairments limiting physical function. © 2017, American College of Rheumatology.

Intestinal epithelial barrier function and tight junction proteins with heat and exercise

PubMed Central

Zuhl, Micah N.; Moseley, Pope L.

2015-01-01

A single layer of enterocytes and tight junctions (intercellular multiprotein complexes) form the intestinal epithelial barrier that controls transport of molecules through transcellular and paracellular pathways. A dysfunctional or “leaky” intestinal tight junction barrier allows augmented permeation of luminal antigens, endotoxins, and bacteria into the blood stream. Various substances and conditions have been shown to affect the maintenance of the intestinal epithelial tight junction barrier. The primary focus of the present review is to analyze the effects of exertional or nonexertional (passive hyperthermia) heat stress on tight junction barrier function in in vitro and in vivo (animals and humans) models. Our secondary focus is to review changes in tight junction proteins in response to exercise or hyperthermic conditions. Finally, we discuss some pharmacological or nutritional interventions that may affect the cellular mechanisms involved in maintaining homeostasis of the intestinal epithelial tight junction barrier during heat stress or exercise. PMID:26359485

Intestinal epithelial barrier function and tight junction proteins with heat and exercise.

PubMed

Dokladny, Karol; Zuhl, Micah N; Moseley, Pope L

2016-03-15

A single layer of enterocytes and tight junctions (intercellular multiprotein complexes) form the intestinal epithelial barrier that controls transport of molecules through transcellular and paracellular pathways. A dysfunctional or "leaky" intestinal tight junction barrier allows augmented permeation of luminal antigens, endotoxins, and bacteria into the blood stream. Various substances and conditions have been shown to affect the maintenance of the intestinal epithelial tight junction barrier. The primary focus of the present review is to analyze the effects of exertional or nonexertional (passive hyperthermia) heat stress on tight junction barrier function in in vitro and in vivo (animals and humans) models. Our secondary focus is to review changes in tight junction proteins in response to exercise or hyperthermic conditions. Finally, we discuss some pharmacological or nutritional interventions that may affect the cellular mechanisms involved in maintaining homeostasis of the intestinal epithelial tight junction barrier during heat stress or exercise. Copyright © 2016 the American Physiological Society.

Multi-layer thin-film electrolytes for metal supported solid oxide fuel cells

NASA Astrophysics Data System (ADS)

Haydn, Markus; Ortner, Kai; Franco, Thomas; Uhlenbruck, Sven; Menzler, Norbert H.; Stöver, Detlev; Bräuer, Günter; Venskutonis, Andreas; Sigl, Lorenz S.; Buchkremer, Hans-Peter; Vaßen, Robert

2014-06-01

A key to the development of metal-supported solid oxide fuel cells (MSCs) is the manufacturing of gas-tight thin-film electrolytes, which separate the cathode from the anode. This paper focuses the electrolyte manufacturing on the basis of 8YSZ (8 mol.-% Y2O3 stabilized ZrO2). The electrolyte layers are applied by a physical vapor deposition (PVD) gas flow sputtering (GFS) process. The gas-tightness of the electrolyte is significantly improved when sequential oxidic and metallic thin-film multi-layers are deposited, which interrupt the columnar grain structure of single-layer electrolytes. Such electrolytes with two or eight oxide/metal layers and a total thickness of about 4 μm obtain leakage rates of less than 3 × 10-4 hPa dm3 s-1 cm-2 (Δp: 100 hPa) at room temperature and therefore fulfill the gas tightness requirements. They are also highly tolerant with respect to surface flaws and particulate impurities which can be present on the graded anode underground. MSC cell tests with double-layer and multilayer electrolytes feature high power densities more than 1.4 W cm-2 at 850 °C and underline the high potential of MSC cells.

Gas Flow Tightly Coupled to Elastoplastic Geomechanics for Tight- and Shale-Gas Reservoirs: Material Failure and Enhanced Permeability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Jihoon; Moridis, George J.

We investigate coupled flow and geomechanics in gas production from extremely low permeability reservoirs such as tight and shale gas reservoirs, using dynamic porosity and permeability during numerical simulation. In particular, we take the intrinsic permeability as a step function of the status of material failure, and the permeability is updated every time step. We consider gas reservoirs with the vertical and horizontal primary fractures, employing the single and dynamic double porosity (dual continuum) models. We modify the multiple porosity constitutive relations for modeling the double porous continua for flow and geomechanics. The numerical results indicate that production of gasmore » causes redistribution of the effective stress fields, increasing the effective shear stress and resulting in plasticity. Shear failure occurs not only near the fracture tips but also away from the primary fractures, which indicates generation of secondary fractures. These secondary fractures increase the permeability significantly, and change the flow pattern, which in turn causes a change in distribution of geomechanical variables. From various numerical tests, we find that shear failure is enhanced by a large pressure drop at the production well, high Biot's coefficient, low frictional and dilation angles. Smaller spacing between the horizontal wells also contributes to faster secondary fracturing. When the dynamic double porosity model is used, we observe a faster evolution of the enhanced permeability areas than that obtained from the single porosity model, mainly due to a higher permeability of the fractures in the double porosity model. These complicated physics for stress sensitive reservoirs cannot properly be captured by the uncoupled or flow-only simulation, and thus tightly coupled flow and geomechanical models are highly recommended to accurately describe the reservoir behavior during gas production in tight and shale gas reservoirs and to smartly design production scenarios.« less

Tactile cues significantly modulate the perception of sweat-induced skin wetness independently of the level of physical skin wetness

PubMed Central

Fournet, Damien; Hodder, Simon; Havenith, George

2015-01-01

Humans sense the wetness of a wet surface through the somatosensory integration of thermal and tactile inputs generated by the interaction between skin and moisture. However, little is known on how wetness is sensed when moisture is produced via sweating. We tested the hypothesis that, in the absence of skin cooling, intermittent tactile cues, as coded by low-threshold skin mechanoreceptors, modulate the perception of sweat-induced skin wetness, independently of the level of physical wetness. Ten males (22 yr old) performed an incremental exercise protocol during two trials designed to induce the same physical skin wetness but to induce lower (TIGHT-FIT) and higher (LOOSE-FIT) wetness perception. In the TIGHT-FIT, a tight-fitting clothing ensemble limited intermittent skin-sweat-clothing tactile interactions. In the LOOSE-FIT, a loose-fitting ensemble allowed free skin-sweat-clothing interactions. Heart rate, core and skin temperature, galvanic skin conductance (GSC), and physical (wbody) and perceived skin wetness were recorded. Exercise-induced sweat production and physical wetness increased significantly [GSC: 3.1 μS, SD 0.3 to 18.8 μS, SD 1.3, P < 0.01; wbody: 0.26 no-dimension units (nd), SD 0.02, to 0.92 nd, SD 0.01, P < 0.01], with no differences between TIGHT-FIT and LOOSE-FIT (P > 0.05). However, the limited intermittent tactile inputs generated by the TIGHT-FIT ensemble reduced significantly whole-body and regional wetness perception (P < 0.01). This reduction was more pronounced when between 40 and 80% of the body was covered in sweat. We conclude that the central integration of intermittent mechanical interactions between skin, sweat, and clothing, as coded by low-threshold skin mechanoreceptors, significantly contributes to the ability to sense sweat-induced skin wetness. PMID:25878153

Gas Flow Tightly Coupled to Elastoplastic Geomechanics for Tight- and Shale-Gas Reservoirs: Material Failure and Enhanced Permeability

DOE PAGES

Kim, Jihoon; Moridis, George J.

2014-12-01

We investigate coupled flow and geomechanics in gas production from extremely low permeability reservoirs such as tight and shale gas reservoirs, using dynamic porosity and permeability during numerical simulation. In particular, we take the intrinsic permeability as a step function of the status of material failure, and the permeability is updated every time step. We consider gas reservoirs with the vertical and horizontal primary fractures, employing the single and dynamic double porosity (dual continuum) models. We modify the multiple porosity constitutive relations for modeling the double porous continua for flow and geomechanics. The numerical results indicate that production of gasmore » causes redistribution of the effective stress fields, increasing the effective shear stress and resulting in plasticity. Shear failure occurs not only near the fracture tips but also away from the primary fractures, which indicates generation of secondary fractures. These secondary fractures increase the permeability significantly, and change the flow pattern, which in turn causes a change in distribution of geomechanical variables. From various numerical tests, we find that shear failure is enhanced by a large pressure drop at the production well, high Biot's coefficient, low frictional and dilation angles. Smaller spacing between the horizontal wells also contributes to faster secondary fracturing. When the dynamic double porosity model is used, we observe a faster evolution of the enhanced permeability areas than that obtained from the single porosity model, mainly due to a higher permeability of the fractures in the double porosity model. These complicated physics for stress sensitive reservoirs cannot properly be captured by the uncoupled or flow-only simulation, and thus tightly coupled flow and geomechanical models are highly recommended to accurately describe the reservoir behavior during gas production in tight and shale gas reservoirs and to smartly design production scenarios.« less

Tight junctions and human diseases.

PubMed

Sawada, Norimasa; Murata, Masaki; Kikuchi, Keisuke; Osanai, Makoto; Tobioka, Hirotoshi; Kojima, Takashi; Chiba, Hideki

2003-09-01

Tight junctions are intercellular junctions adjacent to the apical end of the lateral membrane surface. They have two functions, the barrier (or gate) function and the fence function. The barrier function of tight junctions regulates the passage of ions, water, and various macromolecules, even of cancer cells, through paracellular spaces. The barrier function is thus relevant to edema, jaundice, diarrhea, and blood-borne metastasis. On the other hand, the fence function maintains cell polarity. In other words, tight junctions work as a fence to prevent intermixing of molecules in the apical membrane with those in the lateral membrane. This function is deeply involved in cancer cell biology, in terms of loss of cell polarity. Of the proteins comprising tight junctions, integral membrane proteins occludin, claudins, and JAMs have been recently discovered. Of these molecules, claudins are exclusively responsible for the formation of tight-junction strands and are connected with the actin cytoskeleton mediated by ZO-1. Thus, both functions of tight junctions are dependent on the integrity of the actin cytoskeleton as well as ATP. Mutations in the claudin14 and the claudin16 genes result in hereditary deafness and hereditary hypomagnesemia, respectively. Some pathogenic bacteria and viruses target and affect the tight-junction function, leading to diseases. In this review, the relationship between tight junctions and human diseases is summarized.

Analysis of fracture in sheet bending and roll forming

NASA Astrophysics Data System (ADS)

Deole, Aditya D.; Barnett, Matthew; Weiss, Matthias

2018-05-01

The bending limit or minimum bending radius of sheet metal is conventionally measured in a wiping (swing arm) or in a vee bend test and reported as the minimum radius of the tool over which the sheet can be bent without fracture. Frequently the material kinks while bending so that the actual inner bend radius of the sheet metal is smaller than the tool radius giving rise to inaccuracy in these methods. It has been shown in the previous studies that conventional bend test methods may under-estimate formability in bending dominated processes such as roll forming. A new test procedure is proposed here to improve understanding and measurement of fracture in bending and roll forming. In this study, conventional wiping test and vee bend test have been performed on martensitic steel to determine the minimum bend radius. In addition, the vee bend test is performed in an Erichsen sheet metal tester equipped with the GOM Aramis system to enable strain measurement on the outer surface during bending. The strain measurement before the onset of fracture is then used to determine the minimum bend radius. To compare this result with a technological process, a vee channel is roll formed and in-situ strain measurement carried out with the Vialux Autogrid system. The strain distribution at fracture in the roll forming process is compared with that predicted by the conventional bending tests and by the improved process. It is shown that for this forming operation and material, the improved procedure gives a more accurate prediction of fracture.

Influence of Gestational Age at Initiation of Antihypertensive Therapy: Secondary Analysis of CHIPS Trial Data (Control of Hypertension in Pregnancy Study).

PubMed

Pels, Anouk; Mol, Ben Willem J; Singer, Joel; Lee, Terry; von Dadelszen, Peter; Ganzevoort, Wessel; Asztalos, Elizabeth; Magee, Laura A

2018-06-01

For hypertensive women in CHIPS (Control of Hypertension in Pregnancy Study), we assessed whether the maternal benefits of tight control could be achieved, while minimizing any potentially negative effect on fetal growth, by delaying initiation of antihypertensive therapy until later in pregnancy. For the 981 women with nonsevere, chronic or gestational hypertension randomized to less-tight (target diastolic blood pressure, 100 mm Hg), or tight (target, 85 mm Hg) control, we used mixed-effects logistic regression to examine whether the effect of less-tight (versus tight) control on major outcomes was dependent on gestational age at randomization, adjusting for baseline factors as in the primary analysis and including an interaction term between gestational age at randomization and treatment allocation. Gestational age was considered categorically (quartiles) and continuously (linear or quadratic form), and the optimal functional form selected to provide the best fit to the data based on the Akaike information criterion. Randomization before (but not after) 24 weeks to less-tight (versus tight) control was associated with fewer babies with birth weight <10th centile ( P interaction =0.005), but more preterm birth ( P interaction =0.043), and no effect on perinatal death or high-level neonatal care >48 hours ( P interaction =0.354). For the mother, less-tight (versus tight) control was associated with more severe hypertension at all gestational ages but particularly so before 28 weeks ( P interaction =0.076). In women with nonsevere, chronic, or gestational hypertension, there seems to be no gestational age at which less-tight (versus tight) control is the preferred management strategy to optimize maternal or perinatal outcomes. URL: https://www.isrctn.com. Unique identifier: ISRCTN71416914. © 2018 The Authors.

A unique concept for automatically controlling the braking action of wheeled vehicles during minimum distance stops

NASA Technical Reports Server (NTRS)

Barthlome, D. E.

1975-01-01

Test results of a unique automatic brake control system are outlined and a comparison is made of its mode of operation to that of an existing skid control system. The purpose of the test system is to provide automatic control of braking action such that hydraulic brake pressure is maintained at a near constant, optimum value during minimum distance stops.

Pseudo-magnetic fields of strongly-curved graphene nanobubbles

NASA Astrophysics Data System (ADS)

Liu, Li-Chi

2018-04-01

We use the π-orbital axis vector (POAV) analysis to deal with large curvature effect of graphene in the tight-binding model. To test the validities of pseudo-magnetic fields (PMFs) derived from the tight-binding model and the model with Dirac equation coupled to a curved surface, we propose two types of spatially constant-field topographies for strongly-curved graphene nanobubbles, which correspond to these two models, respectively. It is shown from the latter model that the PMF induced by any spherical graphene nanobubble is always equivalent to the magnetic field caused by one magnetic monopole charge distributed on a complete spherical surface with the same radius. Such a PMF might be attributed to the isometry breaking of a graphene layer attached conformably to a spherical substrate with adhesion.

Tightly-Coupled Integration of Multi-GNSS Single-Frequency RTK and MEMS-IMU for Enhanced Positioning Performance

PubMed Central

Li, Tuan; Zhang, Hongping; Niu, Xiaoji; Gao, Zhouzheng

2017-01-01

Dual-frequency Global Positioning System (GPS) Real-time Kinematics (RTK) has been proven in the past few years to be a reliable and efficient technique to obtain high accuracy positioning. However, there are still challenges for GPS single-frequency RTK, such as low reliability and ambiguity resolution (AR) success rate, especially in kinematic environments. Recently, multi-Global Navigation Satellite System (multi-GNSS) has been applied to enhance the RTK performance in terms of availability and reliability of AR. In order to further enhance the multi-GNSS single-frequency RTK performance in terms of reliability, continuity and accuracy, a low-cost micro-electro-mechanical system (MEMS) inertial measurement unit (IMU) is adopted in this contribution. We tightly integrate the single-frequency GPS/BeiDou/GLONASS and MEMS-IMU through the extended Kalman filter (EKF), which directly fuses the ambiguity-fixed double-differenced (DD) carrier phase observables and IMU data. A field vehicular test was carried out to evaluate the impacts of the multi-GNSS and IMU on the AR and positioning performance in different system configurations. Test results indicate that the empirical success rate of single-epoch AR for the tightly-coupled single-frequency multi-GNSS RTK/INS integration is over 99% even at an elevation cut-off angle of 40°, and the corresponding position time series is much more stable in comparison with the GPS solution. Besides, GNSS outage simulations show that continuous positioning with certain accuracy is possible due to the INS bridging capability when GNSS positioning is not available. PMID:29077070

Tightly-Coupled Integration of Multi-GNSS Single-Frequency RTK and MEMS-IMU for Enhanced Positioning Performance.

PubMed

Li, Tuan; Zhang, Hongping; Niu, Xiaoji; Gao, Zhouzheng

2017-10-27

Dual-frequency Global Positioning System (GPS) Real-time Kinematics (RTK) has been proven in the past few years to be a reliable and efficient technique to obtain high accuracy positioning. However, there are still challenges for GPS single-frequency RTK, such as low reliability and ambiguity resolution (AR) success rate, especially in kinematic environments. Recently, multi-Global Navigation Satellite System (multi-GNSS) has been applied to enhance the RTK performance in terms of availability and reliability of AR. In order to further enhance the multi-GNSS single-frequency RTK performance in terms of reliability, continuity and accuracy, a low-cost micro-electro-mechanical system (MEMS) inertial measurement unit (IMU) is adopted in this contribution. We tightly integrate the single-frequency GPS/BeiDou/GLONASS and MEMS-IMU through the extended Kalman filter (EKF), which directly fuses the ambiguity-fixed double-differenced (DD) carrier phase observables and IMU data. A field vehicular test was carried out to evaluate the impacts of the multi-GNSS and IMU on the AR and positioning performance in different system configurations. Test results indicate that the empirical success rate of single-epoch AR for the tightly-coupled single-frequency multi-GNSS RTK/INS integration is over 99% even at an elevation cut-off angle of 40°, and the corresponding position time series is much more stable in comparison with the GPS solution. Besides, GNSS outage simulations show that continuous positioning with certain accuracy is possible due to the INS bridging capability when GNSS positioning is not available.

Experimental study on the minimum ignition temperature of coal dust clouds in oxy-fuel combustion atmospheres.

PubMed

Wu, Dejian; Norman, Frederik; Verplaetsen, Filip; Van den Bulck, Eric

2016-04-15

BAM furnace apparatus tests were conducted to investigate the minimum ignition temperature of coal dusts (MITC) in O2/CO2 atmospheres with an O2 mole fraction from 20 to 50%. Three coal dusts: Indonesian Sebuku coal, Pittsburgh No.8 coal and South African coal were tested. Experimental results showed that the dust explosion risk increases significantly with increasing O2 mole fraction by reducing the minimum ignition temperature for the three tested coal dust clouds dramatically (even by 100°C). Compared with conventional combustion, the inhibiting effect of CO2 was found to be comparatively large in dust clouds, particularly for the coal dusts with high volatile content. The retardation effect of the moisture content on the ignition of dust clouds was also found to be pronounced. In addition, a modified steady-state mathematical model based on heterogeneous reaction was proposed to interpret the observed experimental phenomena and to estimate the ignition mechanism of coal dust clouds under minimum ignition temperature conditions. The analysis revealed that heterogeneous ignition dominates the ignition mechanism for sub-/bituminous coal dusts under minimum ignition temperature conditions, but the decrease of coal maturity facilitates homogeneous ignition. These results improve our understanding of the ignition behaviour and the explosion risk of coal dust clouds in oxy-fuel combustion atmospheres. Copyright © 2015 Elsevier B.V. All rights reserved.

Transferable tight-binding model for strained group IV and III-V materials and heterostructures

NASA Astrophysics Data System (ADS)

Tan, Yaohua; Povolotskyi, Michael; Kubis, Tillmann; Boykin, Timothy B.; Klimeck, Gerhard

2016-07-01

It is critical to capture the effect due to strain and material interface for device level transistor modeling. We introduce a transferable s p3d5s* tight-binding model with nearest-neighbor interactions for arbitrarily strained group IV and III-V materials. The tight-binding model is parametrized with respect to hybrid functional (HSE06) calculations for varieties of strained systems. The tight-binding calculations of ultrasmall superlattices formed by group IV and group III-V materials show good agreement with the corresponding HSE06 calculations. The application of the tight-binding model to superlattices demonstrates that the transferable tight-binding model with nearest-neighbor interactions can be obtained for group IV and III-V materials.

Loose coupling in the bacterial flagellar motor

PubMed Central

Boschert, Ryan; Adler, Frederick R.; Blair, David F.

2015-01-01

Physiological properties of the flagellar rotary motor have been taken to indicate a tightly coupled mechanism in which each revolution is driven by a fixed number of energizing ions. Measurements that would directly test the tight-coupling hypothesis have not been made. Energizing ions flow through membrane-bound complexes formed from the proteins MotA and MotB, which are anchored to the cell wall and constitute the stator. Genetic and biochemical evidence points to a “power stroke” mechanism in which the ions interact with an aspartate residue of MotB to drive conformational changes in MotA that are transmitted to the rotor protein FliG. Each stator complex contains two separate ion-binding sites, raising the question of whether the power stroke is driven by one, two, or either number of ions. Here, we describe simulations of a model in which the conformational change can be driven by either one or two ions. This loosely coupled model can account for the observed physiological properties of the motor, including those that have been taken to indicate tight coupling; it also accords with recent measurements of motor torque at high load that are harder to explain in tight-coupling models. Under loads relevant to a swimming cell, the loosely coupled motor would perform about as well as a two-proton motor and significantly better than a one-proton motor. The loosely coupled motor is predicted to be especially advantageous under conditions of diminished energy supply, or of reduced temperature, turning faster than an obligatorily two-proton motor while using fewer ions. PMID:25825730

Molecular recognition of pyr mRNA by the Bacillus subtilis attenuation regulatory protein PyrR

PubMed Central

Bonner, Eric R.; D’Elia, John N.; Billips, Benjamin K.; Switzer, Robert L.

2001-01-01

The pyrimidine nucleotide biosynthesis (pyr) operon in Bacillus subtilis is regulated by transcriptional attenuation. The PyrR protein binds in a uridine nucleotide-dependent manner to three attenuation sites at the 5′-end of pyr mRNA. PyrR binds an RNA-binding loop, allowing a terminator hairpin to form and repressing the downstream genes. The binding of PyrR to defined RNA molecules was characterized by a gel mobility shift assay. Titration indicated that PyrR binds RNA in an equimolar ratio. PyrR bound more tightly to the binding loops from the second (BL2 RNA) and third (BL3 RNA) attenuation sites than to the binding loop from the first (BL1 RNA) attenuation site. PyrR bound BL2 RNA 4–5-fold tighter in the presence of saturating UMP or UDP and 150- fold tighter with saturating UTP, suggesting that UTP is the more important co-regulator. The minimal RNA that bound tightly to PyrR was 28 nt long. Thirty-one structural variants of BL2 RNA were tested for PyrR binding affinity. Two highly conserved regions of the RNA, the terminal loop and top of the upper stem and a purine-rich internal bulge and the base pairs below it, were crucial for tight binding. Conserved elements of RNA secondary structure were also required for tight binding. PyrR protected conserved areas of the binding loop in hydroxyl radical footprinting experiments. PyrR likely recognizes conserved RNA sequences, but only if they are properly positioned in the correct secondary structure. PMID:11726695

DETERMINING MINIMUM IGNITION ENERGIES AND QUENCHING DISTANCES OF DIFFICULT-TO-IGNITE COMPOUNDS

EPA Science Inventory

Minimum spark energies and corresponding flat-plate electrode quenching distances required to initiate propagation of a combustion wave have been experimentally measured for four flammable hydrofluorocarbon (HFC) refrigerants and propane using ASTM (American Society for Testing a...

Minimum Conflict Mainstreaming.

ERIC Educational Resources Information Center

Awen, Ed; And Others

Computer technology is discussed as a tool for facilitating the implementation of the mainstreaming process. Minimum conflict mainstreaming/merging (MCM) is defined as an approach which utilizes computer technology to circumvent such structural obstacles to mainstreaming as transportation scheduling, screening and assignment of students, testing,…

46 CFR 42.15-55 - Cargo ports and other similar openings.

Code of Federal Regulations, 2013 CFR

2013-10-01

... be fitted with doors so designed as to ensure watertightness and structural integrity commensurate... shall be subject to tightness tests at the initial survey and at such subsequent surveys or more... the design and proper working of the vessel. (b) Unless permitted by the Commandant the lower edge of...

46 CFR 42.15-55 - Cargo ports and other similar openings.

Code of Federal Regulations, 2012 CFR

2012-10-01

... be fitted with doors so designed as to ensure watertightness and structural integrity commensurate... shall be subject to tightness tests at the initial survey and at such subsequent surveys or more... the design and proper working of the vessel. (b) Unless permitted by the Commandant the lower edge of...

46 CFR 42.15-55 - Cargo ports and other similar openings.

Code of Federal Regulations, 2010 CFR

2010-10-01

... be fitted with doors so designed as to ensure watertightness and structural integrity commensurate... shall be subject to tightness tests at the initial survey and at such subsequent surveys or more... the design and proper working of the vessel. (b) Unless permitted by the Commandant the lower edge of...

46 CFR 42.15-55 - Cargo ports and other similar openings.

Code of Federal Regulations, 2014 CFR

2014-10-01

... be fitted with doors so designed as to ensure watertightness and structural integrity commensurate... shall be subject to tightness tests at the initial survey and at such subsequent surveys or more... the design and proper working of the vessel. (b) Unless permitted by the Commandant the lower edge of...

46 CFR 42.15-55 - Cargo ports and other similar openings.

Code of Federal Regulations, 2011 CFR

2011-10-01

... be fitted with doors so designed as to ensure watertightness and structural integrity commensurate... shall be subject to tightness tests at the initial survey and at such subsequent surveys or more... the design and proper working of the vessel. (b) Unless permitted by the Commandant the lower edge of...

Innovative cold tolerance test for conifer seedlings

Treesearch

Peter A. Balk; Peter Bronnum; Mike Perks; Eva Stattin; Lonneke H. M. van der Geest; Monique F. van Wordragen

2007-01-01

Forest tree nurseries rely on tight scheduling of operations to deliver vital seedlings to the planting site. Cold storage is required to: (1) prevent winter damage, especially in container seedlings; (2) to maintain planting stock in an inactive condition; and (3) to ensure plant supply for geographically distinct planting sites, a definite requirement for large-scale...

40 CFR 280.21 - Upgrading of existing UST systems.

Code of Federal Regulations, 2011 CFR

2011-07-01

... sound and free of corrosion holes prior to installing the cathodic protection system; or (ii) The tank... for corrosion holes by conducting two (2) tightness tests that meet the requirements of § 280.43(c... operation of the cathodic protection system; or (iv) The tank is assessed for corrosion holes by a method...

40 CFR 280.21 - Upgrading of existing UST systems.

Code of Federal Regulations, 2010 CFR

2010-07-01

... sound and free of corrosion holes prior to installing the cathodic protection system; or (ii) The tank... for corrosion holes by conducting two (2) tightness tests that meet the requirements of § 280.43(c... operation of the cathodic protection system; or (iv) The tank is assessed for corrosion holes by a method...

Clinical Implementation Of Megavoltage Cone Beam CT As Part Of An IGRT Program

NASA Astrophysics Data System (ADS)

Gonzalez, Albin; Bauer, Lisa; Kinney, Vicki; Crooks, Cheryl

2008-03-01

Knowing where the tumor is at all times during treatment is the next challenge in the field of radiation therapy. This issue has become more important because with treatments such as Intensity Modulated Radiation Therapy (IMRT), healthy tissue is spared by using very tight margins around the tumor. These tight margins leave very small room for patient setup errors. The use of an imaging modality in the treatment room as a way to localize the tumor for patient set up is generally known as "Image Guided Radiation Therapy" or IGRT. This article deals with a form of IGRT known as Megavoltage Cone Beam Computed Tomography (MCBCT) using a Siemens Oncor linear accelerator currently in use at Firelands Regional Medical Center. With MCBCT, we are capable of acquiring CT images right before the treatment of the patient and then use this information to position the patient tumor according to the treatment plan. This article presents the steps followed in order to clinically implement this system, as well as some of the quality assurance tests suggested by the manufacturer and some tests developed in house

Semidefinite Relaxation-Based Optimization of Multiple-Input Wireless Power Transfer Systems

NASA Astrophysics Data System (ADS)

Lang, Hans-Dieter; Sarris, Costas D.

2017-11-01

An optimization procedure for multi-transmitter (MISO) wireless power transfer (WPT) systems based on tight semidefinite relaxation (SDR) is presented. This method ensures physical realizability of MISO WPT systems designed via convex optimization -- a robust, semi-analytical and intuitive route to optimizing such systems. To that end, the nonconvex constraints requiring that power is fed into rather than drawn from the system via all transmitter ports are incorporated in a convex semidefinite relaxation, which is efficiently and reliably solvable by dedicated algorithms. A test of the solution then confirms that this modified problem is equivalent (tight relaxation) to the original (nonconvex) one and that the true global optimum has been found. This is a clear advantage over global optimization methods (e.g. genetic algorithms), where convergence to the true global optimum cannot be ensured or tested. Discussions of numerical results yielded by both the closed-form expressions and the refined technique illustrate the importance and practicability of the new method. It, is shown that this technique offers a rigorous optimization framework for a broad range of current and emerging WPT applications.

Robust inference from multiple test statistics via permutations: a better alternative to the single test statistic approach for randomized trials.

PubMed

Ganju, Jitendra; Yu, Xinxin; Ma, Guoguang Julie

2013-01-01

Formal inference in randomized clinical trials is based on controlling the type I error rate associated with a single pre-specified statistic. The deficiency of using just one method of analysis is that it depends on assumptions that may not be met. For robust inference, we propose pre-specifying multiple test statistics and relying on the minimum p-value for testing the null hypothesis of no treatment effect. The null hypothesis associated with the various test statistics is that the treatment groups are indistinguishable. The critical value for hypothesis testing comes from permutation distributions. Rejection of the null hypothesis when the smallest p-value is less than the critical value controls the type I error rate at its designated value. Even if one of the candidate test statistics has low power, the adverse effect on the power of the minimum p-value statistic is not much. Its use is illustrated with examples. We conclude that it is better to rely on the minimum p-value rather than a single statistic particularly when that single statistic is the logrank test, because of the cost and complexity of many survival trials. Copyright © 2013 John Wiley & Sons, Ltd.

NASA safety standard for lifting devices and equipment

NASA Astrophysics Data System (ADS)

1990-09-01

NASA's minimum safety requirements are established for the design, testing, inspection, maintenance, certification, and use of overhead and gantry cranes (including top running monorail, underhung, and jib cranes), mobile cranes, derrick hoists, and special hoist supported personnel lifting devices (these do not include elevators, ground supported personnel lifts, or powered platforms). Minimum requirements are also addressed for the testing, inspection, and use of Hydra-sets, hooks, and slings. Safety standards are thoroughly detailed.

Automatic Recognition of Phonemes Using a Syntactic Processor for Error Correction.

DTIC Science & Technology

1980-12-01

OF PHONEMES USING A SYNTACTIC PROCESSOR FOR ERROR CORRECTION THESIS AFIT/GE/EE/8D-45 Robert B. ’Taylor 2Lt USAF Approved for public release...distribution unlimilted. AbP AFIT/GE/EE/ 80D-45 AUTOMATIC RECOGNITION OF PHONEMES USING A SYNTACTIC PROCESSOR FOR ERROR CORRECTION THESIS Presented to the...Testing ..................... 37 Bayes Decision Rule for Minimum Error ........... 37 Bayes Decision Rule for Minimum Risk ............ 39 Mini Max Test

NASA safety standard for lifting devices and equipment

NASA Technical Reports Server (NTRS)

1990-01-01

NASA's minimum safety requirements are established for the design, testing, inspection, maintenance, certification, and use of overhead and gantry cranes (including top running monorail, underhung, and jib cranes), mobile cranes, derrick hoists, and special hoist supported personnel lifting devices (these do not include elevators, ground supported personnel lifts, or powered platforms). Minimum requirements are also addressed for the testing, inspection, and use of Hydra-sets, hooks, and slings. Safety standards are thoroughly detailed.

Subtask – CO 2 storage and enhanced bakken recovery research program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sorensen, James; Hawthorne, Steven; Smith, Steven

Small improvements in productivity could increase technically recoverable oil in the Bakken Petroleum System by billions of barrels. The use of CO 2 for enhanced oil recovery (EOR) in tight oil reservoirs is a relatively new concept. The large-scale injection of CO 2 into the Bakken would also result in the geological storage of significant amounts of CO 2. The Energy & Environmental Research Center (EERC) has conducted laboratory and modeling activities to examine the potential for CO 2 storage and EOR in the Bakken. Specific activities included the characterization and subsequent modeling of North Dakota study areas as wellmore » as dynamic predictive simulations of possible CO 2 injection schemes to predict the potential CO 2 storage and EOR in those areas. Laboratory studies to evaluate the ability of CO 2 to remove hydrocarbons from Bakken rocks and determine minimum miscibility pressures for Bakken oil samples were conducted. Data from a CO 2 injection test conducted in the Elm Coulee area of Montana in 2009 were evaluated with an eye toward the possible application of knowledge gained to future injection tests in other areas. A first-order estimation of potential CO 2 storage capacity in the Bakken Formation in North Dakota was also conducted. Key findings of the program are as follows. The results of the research activities suggest that CO 2 may be effective in enhancing the productivity of oil from the Bakken and that the Bakken may hold the ability to geologically store between 120 Mt and 3.2 Gt of CO 2. However, there are no clear-cut answers regarding the most effective approach for using CO 2 to improve oil productivity or the storage capacity of the Bakken. The results underscore the notion that an unconventional resource will likely require unconventional methods of both assessment and implementation when it comes to the injection of CO 2. In particular, a better understanding of the fundamental mechanisms controlling the interactions between CO 2, oil, and other reservoir fluids in these unique formations is necessary to develop accurate assessments of potential CO 2 storage and EOR in the Bakken. In addition, existing modeling and simulation software packages do not adequately address or incorporate the unique properties of these tight, unconventional reservoirs in terms of their impact on CO 2 behavior. These knowledge gaps can be filled by conducting scaled-up laboratory activities integrated with improved modeling and simulation techniques, the results of which will provide a robust foundation for pilot-scale field injection tests. Finally, field-based data on injection, fluid production, and long-term monitoring from pilot-scale CO 2 injection tests in the Bakken are necessary to verify and validate the findings of the laboratory- and modeling-based research efforts. This subtask was funded through the EERC–U.S. Department of Energy (DOE) Joint Program on Research and Development for Fossil Energy-Related Resources Cooperative Agreement No. DE-FC26-08NT43291. Nonfederal funding was provided by the North Dakota Industrial Commission, Marathon Oil Corporation, Continental Resources Inc., and TAQA North, Ltd.« less

Gastrointestinal cell lines form polarized epithelia with an adherent mucus layer when cultured in semi-wet interfaces with mechanical stimulation.

PubMed

Navabi, Nazanin; McGuckin, Michael A; Lindén, Sara K

2013-01-01

Mucin glycoproteins are secreted in large quantities by mucosal epithelia and cell surface mucins are a prominent feature of the glycocalyx of all mucosal epithelia. Currently, studies investigating the gastrointestinal mucosal barrier use either animal experiments or non-in vivo like cell cultures. Many pathogens cause different pathology in mice compared to humans and the in vitro cell cultures used are suboptimal because they are very different from an in vivo mucosal surface, are often not polarized, lack important components of the glycocalyx, and often lack the mucus layer. Although gastrointestinal cell lines exist that produce mucins or polarize, human cell line models that reproducibly create the combination of a polarized epithelial cell layer, functional tight junctions and an adherent mucus layer have been missing until now. We trialed a range of treatments to induce polarization, 3D-organization, tight junctions, mucin production, mucus secretion, and formation of an adherent mucus layer that can be carried out using standard equipment. These treatments were tested on cell lines of intestinal (Caco-2, LS513, HT29, T84, LS174T, HT29 MTX-P8 and HT29 MTX-E12) and gastric (MKN7, MKN45, AGS, NCI-N87 and its hTERT Clone5 and Clone6) origins using Ussing chamber methodology and (immuno)histology. Semi-wet interface culture in combination with mechanical stimulation and DAPT caused HT29 MTX-P8, HT29 MTX-E12 and LS513 cells to polarize, form functional tight junctions, a three-dimensional architecture resembling colonic crypts, and produce an adherent mucus layer. Caco-2 and T84 cells also polarized, formed functional tight junctions and produced a thin adherent mucus layer after this treatment, but with less consistency. In conclusion, culture methods affect cell lines differently, and testing a matrix of methods vs. cell lines may be important to develop better in vitro models. The methods developed herein create in vitro mucosal surfaces suitable for studies of host-pathogen interactions at the mucosal surface.

Gastrointestinal Cell Lines Form Polarized Epithelia with an Adherent Mucus Layer when Cultured in Semi-Wet Interfaces with Mechanical Stimulation

PubMed Central

Navabi, Nazanin; McGuckin, Michael A.; Lindén, Sara K.

2013-01-01

Mucin glycoproteins are secreted in large quantities by mucosal epithelia and cell surface mucins are a prominent feature of the glycocalyx of all mucosal epithelia. Currently, studies investigating the gastrointestinal mucosal barrier use either animal experiments or non-in vivo like cell cultures. Many pathogens cause different pathology in mice compared to humans and the in vitro cell cultures used are suboptimal because they are very different from an in vivo mucosal surface, are often not polarized, lack important components of the glycocalyx, and often lack the mucus layer. Although gastrointestinal cell lines exist that produce mucins or polarize, human cell line models that reproducibly create the combination of a polarized epithelial cell layer, functional tight junctions and an adherent mucus layer have been missing until now. We trialed a range of treatments to induce polarization, 3D-organization, tight junctions, mucin production, mucus secretion, and formation of an adherent mucus layer that can be carried out using standard equipment. These treatments were tested on cell lines of intestinal (Caco-2, LS513, HT29, T84, LS174T, HT29 MTX-P8 and HT29 MTX-E12) and gastric (MKN7, MKN45, AGS, NCI-N87 and its hTERT Clone5 and Clone6) origins using Ussing chamber methodology and (immuno)histology. Semi-wet interface culture in combination with mechanical stimulation and DAPT caused HT29 MTX-P8, HT29 MTX-E12 and LS513 cells to polarize, form functional tight junctions, a three-dimensional architecture resembling colonic crypts, and produce an adherent mucus layer. Caco-2 and T84 cells also polarized, formed functional tight junctions and produced a thin adherent mucus layer after this treatment, but with less consistency. In conclusion, culture methods affect cell lines differently, and testing a matrix of methods vs. cell lines may be important to develop better in vitro models. The methods developed herein create in vitro mucosal surfaces suitable for studies of host-pathogen interactions at the mucosal surface. PMID:23869232

The Minimum Impulse Thruster

NASA Technical Reports Server (NTRS)

Parker, J. Morgan; Wilson, Michael J.

2005-01-01

The Minimum Impulse Thruster (MIT) was developed to improve the state-of-the-art minimum impulse capability of hydrazine monopropellant thrusters. Specifically, a new fast response solenoid valve was developed, capable of responding to a much shorter electrical pulse width, thereby reducing the propellant flow time and the minimum impulse bit. The new valve was combined with the Aerojet MR-103, 0.2 lbf (0.9 N) thruster and put through an extensive Delta-qualification test program, resulting in a factor of 5 reduction in the minimum impulse bit, from roughly 1.1 milli-lbf-seconds (5 milliNewton seconds) to - 0.22 milli-lbf-seconds (1 mN-s). To maintain it's extensive heritage, the thruster itself was left unchanged. The Minimum Impulse Thruster provides mission and spacecraft designers new design options for precision pointing and precision translation of spacecraft.

Development of Freshwater Grout Subsequent to the Bell Canyon Tests (BCT).

DTIC Science & Technology

1986-04-01

specimens of those grouts cured and studied in the SL, to three-years age. Selected data from earlier tests of related fresh-water grouts are...specimens were either coated with a strippable plastic momn;rane, or sealed in plastic cylinders with tightly fitting lids. Sealed in plastiC habs in...for expansion prisms, the strippable coating applied to SPDV specimens did not prevent water loss. Lower strength gain may be attributable to partial

System development and early biological tests in NASA's biomass production chamber

NASA Technical Reports Server (NTRS)

Wheeler, R. M.; Mackowiak, C. L.; Dreschel, T. W.; Sager, J. C.; Prince, R. P.; Knott, W. M.; Hinkle, C. R.; Strayer, R. F.

1990-01-01

The Biomass Production Chamber at Kennedy Space Center was constructed to conduct large scale plant growth studies for NASA's CELSS program. Over the past four years, physical systems and computer control software have been continually upgraded and the degree of atmospheric leakage from the chamber has decreased from about 40 to 5 percent of the total volume per day. Early tests conducted with a limited degree of closure showed that total crop (wheat) growth from the best trays was within 80 percent of reported optimal yields for similar light levels. Yields from subsequent tests under more tightly closed conditions have not been as good--up to only 65 percent of optimal yields. Yields appear to have decreased with increasing closure, yet potential problems exist in cultural techniques and further studies are warranted. With the ability to tightly seal the chamber, quantitative data were gathered on CO2 and water exchange rates. Results showed that stand photosynthesis and transpiration reached a peak near 25 days after planting, soon after full vegetative ground cover was established. In the final phase of testing when atmospheric closure was the highest, ethylene gas levels in the chamber rose from about 10 to nearly 120 ppb. Evidence suggests that the ethylene originated from the wheat plants themselves and may have caused an epinastic rolling of the leaves, but no apparent detrimental effects on whole plant function.

Is It Working? Distractor Analysis Results from the Test Of Astronomy STandards (TOAST) Assessment Instrument

NASA Astrophysics Data System (ADS)

Slater, Stephanie

2009-05-01

The Test Of Astronomy STandards (TOAST) assessment instrument is a multiple-choice survey tightly aligned to the consensus learning goals stated by the American Astronomical Society - Chair's Conference on ASTRO 101, the American Association of the Advancement of Science's Project 2061 Benchmarks, and the National Research Council's National Science Education Standards. Researchers from the Cognition in Astronomy, Physics and Earth sciences Research (CAPER) Team at the University of Wyoming's Science and Math Teaching Center (UWYO SMTC) have been conducting a question-by-question distractor analysis procedure to determine the sensitivity and effectiveness of each item. In brief, the frequency each possible answer choice, known as a foil or distractor on a multiple-choice test, is determined and compared to the existing literature on the teaching and learning of astronomy. In addition to having statistical difficulty and discrimination values, a well functioning assessment item will show students selecting distractors in the relative proportions to how we expect them to respond based on known misconceptions and reasoning difficulties. In all cases, our distractor analysis suggests that all items are functioning as expected. These results add weight to the validity of the Test Of Astronomy STandards (TOAST) assessment instrument, which is designed to help instructors and researchers measure the impact of course-length duration instructional strategies for undergraduate science survey courses with learning goals tightly aligned to the consensus goals of the astronomy education community.

Belching, regurgitation, chest tightness and dyspnea: not gastroesophageal reflux disease but asthma.

PubMed

Zhang, Jing-Xi; Zhan, Xian-Bao; Bai, Chong; Li, Qiang

2015-02-07

Belching is a common symptom of gastroesophageal reflux disease. If the symptoms are not relieved after anti-reflux treatment, another etiology should be considered. Here, we report a case of a 43-year-old man who presented with belching, regurgitation, chest tightness and dyspnea for 18 mo, which became gradually more severe. Gastroscopic examination suggested superficial gastritis. Twenty-four-hour esophageal pH monitoring showed that the Demeester score was 11.4, in the normal range. High-resolution manometry showed that integrated relaxation pressure and intrabolus pressure were higher than normal (20 mmHg and 22.4 mmHg, respectively), indicating gastroesophageal junction outflow tract obstruction. Pulmonary function test showed severe obstructive ventilation dysfunction [forced expiratory volume in 1 second (FEV1)/forced vital capacity 32%, FEV1 was 1.21 L, occupying 35% predicted value after salbuterol inhalation], and positive bronchial dilation test (∆FEV1 260 mL, ∆FEV1% 27%). Skin prick test showed Dermatophagoides farinae (++), house dust mite (++++), and shrimp protein (++). Fractional exhaled nitric oxide measurement was 76 ppb. All the symptoms were alleviated completely and pulmonary function increased after combination therapy with corticosteroids and long-acting β2-agonist. Bronchial asthma was eventually diagnosed by laboratory tests and the effect of anti-asthmatic treatment, therefore, physicians, especially the Gastrointestinal physicians, should pay attention to the belching symptoms of asthma.

Mobile Romberg test assessment (mRomberg).

PubMed

Galán-Mercant, Alejandro; Cuesta-Vargas, Antonio I

2014-09-12

The diagnosis of frailty is based on physical impairments and clinicians have indicated that early detection is one of the most effective methods for reducing the severity of physical frailty. Maybe, an alternative to the classical diagnosis could be the instrumentalization of classical functional testing, as Romberg test or Timed Get Up and Go Test. The aim of this study was (I) to measure and describe the magnitude of accelerometry values in the Romberg test in two groups of frail and non-frail elderly people through instrumentation with the iPhone 4®, (II) to analyse the performances and differences between the study groups, and (III) to analyse the performances and differences within study groups to characterise accelerometer responses to increasingly difficult challenges to balance. This is a cross-sectional study of 18 subjects over 70 years old, 9 frail subjects and 9 non-frail subjects. The non-parametric Mann-Whitney U test was used for between-group comparisons in means values derived from different tasks. The Wilcoxon Signed-Rank test was used to analyse differences between different variants of the test in both independent study groups. The highest difference between groups was found in the accelerometer values with eyes closed and feet parallel: maximum peak acceleration in the lateral axis (p < 0.01), minimum peak acceleration in the lateral axis (p < 0.01) and minimum peak acceleration from the resultant vector (p < 0.01). Subjects with eyes open and feet parallel, greatest differences found between the groups were in the maximum peak acceleration in the lateral axis (p < 0.01), minimum peak acceleration in the lateral axis (p < 0.01) and minimum peak acceleration from the resultant vector (p < 0.001). With eyes closed and feet in tandem, the greatest differences found between the groups were in the minimum peak acceleration in the lateral axis (p < 0.01). The accelerometer fitted in the iPhone 4® is able to study and analyse the kinematics of the Romberg test between frail and non-frail elderly people. In addition, the results indicate that the accelerometry values also were significantly different between the frail and non-frail groups, and that values from the accelerometer accelerometer increased as the test was made more complicated.

Tight junctions and the modulation of barrier function in disease

PubMed Central

2008-01-01

Tight junctions create a paracellular barrier in epithelial and endothelial cells protecting them from the external environment. Two different classes of integral membrane proteins constitute the tight junction strands in epithelial cells and endothelial cells, occludin and members of the claudin protein family. In addition, cytoplasmic scaffolding molecules associated with these junctions regulate diverse physiological processes like proliferation, cell polarity and regulated diffusion. In many diseases, disruption of this regulated barrier occurs. This review will briefly describe the molecular composition of the tight junctions and then present evidence of the link between tight junction dysfunction and disease. PMID:18415116

Possible Involvement of Tight Junctions, Extracellular Matrix and Nuclear Receptors in Epithelial Differentiation

PubMed Central

Ichikawa-Tomikawa, Naoki; Sugimoto, Kotaro; Satohisa, Seiro; Nishiura, Keisuke; Chiba, Hideki

2011-01-01

Tight junctions are intercellular junctions localized at the most apical end of the lateral plasma membrane. They consist of four kinds of transmembrane proteins (occludin, claudins, junctional adhesion molecules, and tricellulin) and huge numbers of scaffolding proteins and contribute to the paracellular barrier and fence function. The mutation and deletion of these proteins impair the functions of tight junctions and cause various human diseases. In this paper, we provide an overview of recent studies on transmembrane proteins of tight junctions and highlight the functional significance of tight junctions, extracellular matrix, and nuclear receptors in epithelial differentiation. PMID:22162632

An Axial-Torsional, Thermomechanical Fatigue Testing Technique

NASA Technical Reports Server (NTRS)

Kalluri, Sreeramesh; Bonacuse, Peter J.

1995-01-01

A technique for conducting strain-controlled, thermomechanical, axial-torsional fatigue tests on thin-walled tubular specimens was developed. Three waveforms of loading, namely, the axial strain waveform, the engineering shear strain waveform, and the temperature waveform were required in these tests. The phasing relationships between the mechanical strain waveforms and the temperature and axial strain waveforms were used to define a set of four axial-torsional, thermomechanical fatigue (AT-TMF) tests. Real-time test control (3 channels) and data acquisition (a minimum of 7 channels) were performed with a software program written in C language and executed on a personal computer. The AT-TMF testing technique was used to investigate the axial-torsional thermomechanical fatigue behavior of a cobalt-base superalloy, Haynes 188. The maximum and minimum temperatures selected for the AT-TMF tests were 760 and 316 C, respectively. Details of the testing system, calibration of the dynamic temperature profile of the thin-walled tubular specimen, thermal strain compensation technique, and test control and data acquisition schemes, are reported. The isothermal, axial, torsional, and in- and out-of-phase axial-torsional fatigue behaviors of Haynes 188 at 316 and 760 C were characterized in previous investigations. The cyclic deformation and fatigue behaviors of Haynes 188 in AT-TMF tests are compared to the previously reported isothermal axial-torsional behavior of this superalloy at the maximum and minimum temperatures.

Quantifying the Impact of Additional Laboratory Tests on the Quality of a Geomechanical Model

NASA Astrophysics Data System (ADS)

Fillion, Marie-Hélène; Hadjigeorgiou, John

2017-05-01

In an open-pit mine operation, the design of safe and economically viable slopes can be significantly influenced by the quality and quantity of collected geomechanical data. In several mining jurisdictions, codes and standards are available for reporting exploration data, but similar codes or guidelines are not formally available or enforced for geotechnical design. Current recommendations suggest a target level of confidence in the rock mass properties used for slope design. As these guidelines are qualitative and somewhat subjective, questions arise regarding the minimum number of tests to perform in order to reach the proposed level of confidence. This paper investigates the impact of defining a priori the required number of laboratory tests to conduct on rock core samples based on the geomechanical database of an operating open-pit mine in South Africa. In this review, to illustrate the process, the focus is on uniaxial compressive strength properties. Available strength data for 2 project stages were analysed using the small-sampling theory and the confidence interval approach. The results showed that the number of specimens was too low to obtain a reliable strength value for some geotechnical domains even if more specimens than the minimum proposed by the ISRM suggested methods were tested. Furthermore, the testing sequence used has an impact on the minimum number of specimens required. Current best practice cannot capture all possibilities regarding the geomechanical property distributions, and there is a demonstrated need for a method to determine the minimum number of specimens required while minimising the influence of the testing sequence.

Experiments on Exhaust Noise of Tightly Integrated Propulsion Systems

NASA Technical Reports Server (NTRS)

Bridges, James E.; Brown, Clifford A.; Bozak, Richard F.

2014-01-01

A wide-ranging series of tests have been completed that seek to map the effects of installation, including jet by jet interaction effects, on exhaust noise from various nozzles in forward flight. The primary data was far-field acoustic spectral directivity. The goals of the test series were (i) to generate enough data for empirical models of the different effects, and (ii) to provide data for advanced computational noise predictions methods applied to simplified yet realistic configurations. Data is presented that demonstrate several checks on data quality and that provide an overview of trends observed to date. Among the findings presented here: (i) Data was repeatable between jet rigs for single nozzles with and without surfaces to within +/- 0.5 dB. (ii) The presence of a second jet caused a strong reduction of the summed noise in the plane of the two plumes and an increase over the expected source doubling in most other azimuthal planes. (iii) The impact of the second jet was reduced when the jets were unheated. (iv) The impact of adding a second isolated rectangular jet was relatively independent of the nozzle aspect ratio up to aspect ratio 8:1. (v) Forward flight had similar impact on a high aspect ratio (8:1) jet as on an axisymmetric jet, except at the peak noise angle where the impact was less. (vi) The effect of adding a second round jet to a tightly integrated nozzle where the nozzle lip was less than a diameter from the surface was very dependent upon the length of the surface downstream of the nozzle. (vii) When the nozzles were rectangular and tightly integrated with the airframe surface the impact of a second jet was very dependent upon how close together the two jets were. This paper serves as an overview of the test; other papers presented in the same conference will give more detailed analysis of the results.

Less-tight versus tight control of hypertension in pregnancy.

PubMed

Magee, Laura A; von Dadelszen, Peter; Rey, Evelyne; Ross, Susan; Asztalos, Elizabeth; Murphy, Kellie E; Menzies, Jennifer; Sanchez, Johanna; Singer, Joel; Gafni, Amiram; Gruslin, Andrée; Helewa, Michael; Hutton, Eileen; Lee, Shoo K; Lee, Terry; Logan, Alexander G; Ganzevoort, Wessel; Welch, Ross; Thornton, Jim G; Moutquin, Jean-Marie

2015-01-29

The effects of less-tight versus tight control of hypertension on pregnancy complications are unclear. We performed an open, international, multicenter trial involving women at 14 weeks 0 days to 33 weeks 6 days of gestation who had nonproteinuric preexisting or gestational hypertension, office diastolic blood pressure of 90 to 105 mm Hg (or 85 to 105 mm Hg if the woman was taking antihypertensive medications), and a live fetus. Women were randomly assigned to less-tight control (target diastolic blood pressure, 100 mm Hg) or tight control (target diastolic blood pressure, 85 mm Hg). The composite primary outcome was pregnancy loss or high-level neonatal care for more than 48 hours during the first 28 postnatal days. The secondary outcome was serious maternal complications occurring up to 6 weeks post partum or until hospital discharge, whichever was later. Included in the analysis were 987 women; 74.6% had preexisting hypertension. The primary-outcome rates were similar among 493 women assigned to less-tight control and 488 women assigned to tight control (31.4% and 30.7%, respectively; adjusted odds ratio, 1.02; 95% confidence interval [CI], 0.77 to 1.35), as were the rates of serious maternal complications (3.7% and 2.0%, respectively; adjusted odds ratio, 1.74; 95% CI, 0.79 to 3.84), despite a mean diastolic blood pressure that was higher in the less-tight-control group by 4.6 mm Hg (95% CI, 3.7 to 5.4). Severe hypertension (≥160/110 mm Hg) developed in 40.6% of the women in the less-tight-control group and 27.5% of the women in the tight-control group (P<0.001). We found no significant between-group differences in the risk of pregnancy loss, high-level neonatal care, or overall maternal complications, although less-tight control was associated with a significantly higher frequency of severe maternal hypertension. (Funded by the Canadian Institutes of Health Research; CHIPS Current Controlled Trials number, ISRCTN71416914; ClinicalTrials.gov number, NCT01192412.).

Isoflavone formononetin from red propolis acts as a fungicide against Candida sp.

PubMed

das Neves, Michelline Viviane Marques; da Silva, Tânia Maria Sarmento; Lima, Edeltrudes de Oliveira; da Cunha, Emídio Vasconcelos Leitão; Oliveira, Eduardo de Jesus

2016-01-01

A bioassay-guided fractionation of two samples of Brazilian red propolis (from Igarassu, PE, Brazil, hereinafter propolis 1 and 2) was conducted in order to determine the components responsible for its antimicrobial activity, especially against Candida spp. Samples of both the crude powdered resin and the crude ethanolic extract of propolis from both locations inhibited the growth of all 12 tested Candida strains, with a minimum inhibitory concentration of 256μg/mL. The hexane, acetate and methanol fractions of propolis 1 also inhibited all strains with minimum inhibitory concentration values ranging from 128 to 512μg/mL for the six bacteria tested and from 32 to 1024μg/mL for the yeasts. Similarly, hexane and acetate fractions of propolis sample 2 inhibited all microorganisms tested, with minimum inhibitory concentration values of 512μg/mL for bacteria and 32μg/mL for yeasts. The extracts were analyzed by HPLC and their phenolic profile allowed us to identify and quantitate one phenolic acid and seven flavonoids in the crude ethanolic extract. Formononetin and pinocembrin were the major constituents amongst the identified compounds. Formononetin was detected in all extracts and fractions tested, except for the methanolic fraction of sample 2. The isolated isoflavone formononetin inhibited the growth of all the microorganisms tested, with a minimum inhibitory concentration of 200μg/mL for the six bacteria strains tested and 25μg/mL for the six yeasts. Formononetin also exhibited fungicidal activity against five of the six yeasts tested. Taken together our results demonstrate that the isoflavone formononetin is implicated in the reported antimicrobial activity of red propolis. Copyright © 2015 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda. All rights reserved.

Isoflavone formononetin from red propolis acts as a fungicide against Candida sp

PubMed Central

das Neves, Michelline Viviane Marques; da Silva, Tânia Maria Sarmento; Lima, Edeltrudes de Oliveira; da Cunha, Emídio Vasconcelos Leitão; Oliveira, Eduardo de Jesus

2016-01-01

A bioassay-guided fractionation of two samples of Brazilian red propolis (from Igarassu, PE, Brazil, hereinafter propolis 1 and 2) was conducted in order to determine the components responsible for its antimicrobial activity, especially against Candida spp. Samples of both the crude powdered resin and the crude ethanolic extract of propolis from both locations inhibited the growth of all 12 tested Candida strains, with a minimum inhibitory concentration of 256 μg/mL. The hexane, acetate and methanol fractions of propolis 1 also inhibited all strains with minimum inhibitory concentration values ranging from 128 to 512 μg/mL for the six bacteria tested and from 32 to 1024 μg/mL for the yeasts. Similarly, hexane and acetate fractions of propolis sample 2 inhibited all microorganisms tested, with minimum inhibitory concentration values of 512 μg/mL for bacteria and 32 μg/mL for yeasts. The extracts were analyzed by HPLC and their phenolic profile allowed us to identify and quantitate one phenolic acid and seven flavonoids in the crude ethanolic extract. Formononetin and pinocembrin were the major constituents amongst the identified compounds. Formononetin was detected in all extracts and fractions tested, except for the methanolic fraction of sample 2. The isolated isoflavone formononetin inhibited the growth of all the microorganisms tested, with a minimum inhibitory concentration of 200 μg/mL for the six bacteria strains tested and 25 μg/mL for the six yeasts. Formononetin also exhibited fungicidal activity against five of the six yeasts tested. Taken together our results demonstrate that the isoflavone formononetin is implicated in the reported antimicrobial activity of red propolis. PMID:26887239

Potential evaluation of CO2 storage and enhanced oil recovery of tight oil reservoir in the Ordos Basin, China.

PubMed

Tian, Xiaofeng; Cheng, Linsong; Cao, Renyi; Zhang, Miaoyi; Guo, Qiang; Wang, Yimin; Zhang, Jian; Cui, Yu

2015-07-01

Carbon -di-oxide (CO2) is regarded as the most important greenhouse gas to accelerate climate change and ocean acidification. The Chinese government is seeking methods to reduce anthropogenic CO2 gas emission. CO2 capture and geological storage is one of the main methods. In addition, injecting CO2 is also an effective method to replenish formation energy in developing tight oil reservoirs. However, exiting methods to estimate CO2 storage capacity are all based on the material balance theory. This was absolutely correct for normal reservoirs. However, as natural fractures widely exist in tight oil reservoirs and majority of them are vertical ones, tight oil reservoirs are not close. Therefore, material balance theory is not adaptive. In the present study, a new method to calculate CO2 storage capacity is presented. The CO2 effective storage capacity, in this new method, consisted of free CO2, CO2 dissolved in oil and CO2 dissolved in water. Case studies of tight oil reservoir from Ordos Basin was conducted and it was found that due to far lower viscosity of CO2 and larger solubility in oil, CO2 could flow in tight oil reservoirs more easily. As a result, injecting CO2 in tight oil reservoirs could obviously enhance sweep efficiency by 24.5% and oil recovery efficiency by 7.5%. CO2 effective storage capacity of Chang 7 tight oil reservoir in Longdong area was 1.88 x 10(7) t. The Chang 7 tight oil reservoir in Ordos Basin was estimated to be 6.38 x 10(11) t. As tight oil reservoirs were widely distributed in Songliao Basin, Sichuan Basin and so on, geological storage capacity of CO2 in China is potential.

OS082. CHIPS-Child: Testing the developmental origins hypothesis.

PubMed

Magee, L A; Synnes, A

2012-07-01

CHIPS-Child is a natural test of the Developmental Origins of Health and Disease hypothesis (DOHaD) [1,2]. Reduced fetal growth rate is associated with adult cardiovascular risk markers (e.g., obesity) and disease [3,4]. Evidence worldwide indicates that this relationship is independent of birth weight. The leading theory describes 'developmental programming'in utero leading to permanent alteration of the fetal genome. While those changes are adaptive in utero, they may be maladaptive postnatally. To directly test, for the first time in humans, whether differential blood pressure (BP) control in pregnancy has developmental programming effects, independent of birth weight. We predict that, like famine or protein malnutrition, 'tight' (vs. 'less tight') control of maternal BP will be associated with fetal under-nutrition and effects will be consistent with developmental programming. CHIPS-Child is a parallel, ancillary study to the CHIPS randomized controlled trial (RCT). CHIPS is designed to determine whether 'less tight' control [target diastolic BP (dBP) 100mmHg] or 'tight' control [target dBP 85mmHg] of non-proteinuric hypertension in pregnancy is better for the baby without increasing maternal risk. CHIPS-Child will examine offspring of CHIPS participants non-invasively at 12m corrected post-gestational age (±2m) for anthropometry, hair cortisol, buccal swabs for epigenetic testing and a maternal questionnaire about infant feeding practices and background. Annual contact will be maintained in years 2-5 and will include annual parental measurement of the child's height, weight and waist circumference. CHIPS will recruit 1028 women. We estimate that 80% of CHIPS centres will participate in CHIPS-Child, approximately 97% of babies will survive, and 90% of children will be followed to 12m resulting in a sample size of 626. Power will be >80% to detect a between-group difference of ⩾0.25 in 'change in z-score for weight' between birth and 12m (2-sided alpha=0.05, SD 1). Recruitment has begun. The primary outcome will be the between-group difference in early postnatal weight gain ('change in z score for weight') between birth and 12m (p<0.05). Secondary:outcomes are (i) hypothalamic pituitary adrenal axis function (hair cortisol for overall cortisol production); and (ii) between-groups differences in DNA methylation, using targeted (genes associated with growth, obesity, cardiovascular disease, and/or a developmental programming effect) and global (genome-wide microarray) methods. CHIPS-Child offers a unique opportunity to both clarify whether differential dBP control in pregnancy has developmental programming effects and contribute to our understanding of human biology and diversity in a way that a cross-sectional or other observational studies cannot. Copyright © 2012. Published by Elsevier B.V.

Derivation and test of elevated temperature thermal-stress-free fastener concept

NASA Technical Reports Server (NTRS)

Sawyer, J. W.; Blosser, M. L.; Mcwithey, R. R.

1985-01-01

Future aerospace vehicles must withstand high temperatures and be able to function over a wide temperature range. New composite materials are being developed for use in designing high-temperature lightweight structures. Due to the difference between coefficients of thermal expansion for the new composite materials and conventional high-temperature metallic fasteners, innovative joining techniques are needed to produce tight joints at all temperatures without excessive thermal stresses. A thermal-stress-free fastening technique is presented that can be used to provide structurally tight joints at all temperatures even when the fastener and joined materials have different coefficients of thermal expansion. The derivation of thermal-stress-free fasteners and joint shapes is presented for a wide variety of fastener materials and materials being joined together. Approximations to the thermal-stress-free shapes that result in joints with low-thermal-stresses and that simplify the fastener/joint shape are discussed. The low-thermal-stress fastener concept is verified by thermal and shear tests in joints using oxide-dispersion-strengthened alloy fasteners in carbon-carbon material. The test results show no evidence of thermal stress damage for temperatures up to 2000 F and the resulting joints carried shear loads at room temperature typical of those for conventional joints.

Dendritic nonlinearities reduce network size requirements and mediate ON and OFF states of persistent activity in a PFC microcircuit model.

PubMed

Papoutsi, Athanasia; Sidiropoulou, Kyriaki; Poirazi, Panayiota

2014-07-01

Technological advances have unraveled the existence of small clusters of co-active neurons in the neocortex. The functional implications of these microcircuits are in large part unexplored. Using a heavily constrained biophysical model of a L5 PFC microcircuit, we recently showed that these structures act as tunable modules of persistent activity, the cellular correlate of working memory. Here, we investigate the mechanisms that underlie persistent activity emergence (ON) and termination (OFF) and search for the minimum network size required for expressing these states within physiological regimes. We show that (a) NMDA-mediated dendritic spikes gate the induction of persistent firing in the microcircuit. (b) The minimum network size required for persistent activity induction is inversely proportional to the synaptic drive of each excitatory neuron. (c) Relaxation of connectivity and synaptic delay constraints eliminates the gating effect of NMDA spikes, albeit at a cost of much larger networks. (d) Persistent activity termination by increased inhibition depends on the strength of the synaptic input and is negatively modulated by dADP. (e) Slow synaptic mechanisms and network activity contain predictive information regarding the ability of a given stimulus to turn ON and/or OFF persistent firing in the microcircuit model. Overall, this study zooms out from dendrites to cell assemblies and suggests a tight interaction between dendritic non-linearities and network properties (size/connectivity) that may facilitate the short-memory function of the PFC.

Plasma sprayed metal supported YSZ/Ni-LSGM-LSCF ITSOFC with nanostructured anode

NASA Astrophysics Data System (ADS)

Hwang, Changsing; Tsai, Chun-Huang; Lo, Chih-Hung; Sun, Cha-Hong

Intermediate temperature solid oxide fuel cells (ITSOFCs) supported by a porous Ni-substrate and based on Sr and Mg doped lanthanum gallate (LSGM) electrolyte, lanthanum strontium cobalt ferrite (LSCF) cathode and nanostructured yttria stabilized zirconia-nickel (YSZ/Ni) cermet anode have been fabricated successfully by atmospheric plasma spraying (APS). From ac impedance analysis, the sprayed YSZ/Ni cermet anode with a novel nanostructure and advantageous triple phase boundaries after hydrogen reduction has a low resistance. It shows a good electrocatalytic activity for hydrogen oxidation reactions. The sprayed LSGM electrolyte with ∼60 μm in thickness and ∼0.054 S cm -1 conductivity at 800 °C shows a good gas tightness and gives an open circuit voltage (OCV) larger than 1 V. The sprayed LSCF cathode with ∼30 μm in thickness and ∼30% porosity has a minimum resistance after being heated at 1000 °C for 2 h. This cathode keeps right phase structure and good porous network microstructure for conducting electrons and negative oxygen ions. The APS sprayed cell after being heated at 1000 °C for 2 h has a minimum inherent resistance and achieves output power densities of ∼440 mW cm -2 at 800 °C, ∼275 mW cm -2 at 750 °C and ∼170 mW cm -2 at 700 °C. Results from SEM, XRD, ac impedance analysis and I- V- P measurements are presented here.

Persistent millennial-scale link between Greenland climate and northern Pacific Oxygen Minimum Zone under interglacial conditions

NASA Astrophysics Data System (ADS)

Cartapanis, O.; Tachikawa, K.; Romero, O. E.; Bard, E.

2014-02-01

The intensity and/or extent of the northeastern Pacific Oxygen Minimum Zone (OMZ) varied in-phase with the Northern Hemisphere high latitude climate on millennial timescales during the last glacial period, indicating the occurrence of atmospheric and oceanic connections under glacial conditions. While millennial variability was reported for both the Greenland and the northern Atlantic Ocean during the last interglacial period, the climatic connections with the northeastern Pacific OMZ has not yet been observed under warm interglacial conditions. Here we present a new geochemical dataset, spanning the past 120 ka, for major components (terrigenous fraction, marine organic matter, biogenic opal, and carbonates) generated by X-ray fluorescence scanning alongside with biological productivity and redox sensitive trace element content (Mo, Ni, Cd) of sediment core MD02-2508 at 23° N, retrieved from the northern limit of the modern OMZ. Based on elemental ratios Si / Ti (proxy for opal), Cd / Al and Ni / Al, we suggest that biological productivity was high during the last interglacial (MIS5). Highly resolved opal reconstruction presents millennial variability corresponding to all the Dansgaard-Oeschger interstadial events over the last interglacial, while the Mo / Al ratio indicates reduced oxygenation during these events. Extremely high opal content during warm interstadials suggests high diatom productivity. Despite the different climatic and oceanic background between glacial and interglacial periods, rapid variability in the northeastern Pacific OMZ seems to be tightly related to Northern Hemisphere high latitude climate via atmospheric and possibly oceanic processes.

18 CFR 270.304 - Tight formation gas.

Code of Federal Regulations, 2011 CFR

2011-04-01

... determination that natural gas is tight formation gas must file with the jurisdictional agency an application... formation; (d) A complete copy of the well log, including the log heading identifying the designated tight...

Impact of HIPAA’s Minimum Necessary Standard on Genomic Data Sharing

PubMed Central

Evans, Barbara J.; Jarvik, Gail P.

2017-01-01

Purpose This article provides a brief introduction to the HIPAA Privacy Rule’s minimum necessary standard, which applies to sharing of genomic data, particularly clinical data, following 2013 Privacy Rule revisions. Methods This research used the Thomson Reuters Westlaw™ database and law library resources in its legal analysis of the HIPAA privacy tiers and the impact of the minimum necessary standard on genomic data-sharing. We considered relevant example cases of genomic data-sharing needs. Results In a climate of stepped-up HIPAA enforcement, this standard is of concern to laboratories that generate, use, and share genomic information. How data-sharing activities are characterized—whether for research, public health, or clinical interpretation and medical practice support—affects how the minimum necessary standard applies and its overall impact on data access and use. Conclusion There is no clear regulatory guidance on how to apply HIPAA’s minimum necessary standard when considering the sharing of information in the data-rich environment of genomic testing. Laboratories that perform genomic testing should engage with policy-makers to foster sound, well-informed policies and appropriate characterization of data-sharing activities to minimize adverse impacts on day-to-day workflows. PMID:28914268

Impact of HIPAA's minimum necessary standard on genomic data sharing.

PubMed

Evans, Barbara J; Jarvik, Gail P

2018-04-01

This article provides a brief introduction to the Health Insurance Portability and Accountability Act of 1996 (HIPAA) Privacy Rule's minimum necessary standard, which applies to sharing of genomic data, particularly clinical data, following 2013 Privacy Rule revisions. This research used the Thomson Reuters Westlaw database and law library resources in its legal analysis of the HIPAA privacy tiers and the impact of the minimum necessary standard on genomic data sharing. We considered relevant example cases of genomic data-sharing needs. In a climate of stepped-up HIPAA enforcement, this standard is of concern to laboratories that generate, use, and share genomic information. How data-sharing activities are characterized-whether for research, public health, or clinical interpretation and medical practice support-affects how the minimum necessary standard applies and its overall impact on data access and use. There is no clear regulatory guidance on how to apply HIPAA's minimum necessary standard when considering the sharing of information in the data-rich environment of genomic testing. Laboratories that perform genomic testing should engage with policy makers to foster sound, well-informed policies and appropriate characterization of data-sharing activities to minimize adverse impacts on day-to-day workflows.

Minimum Error Bounded Efficient L1 Tracker with Occlusion Detection (PREPRINT)

DTIC Science & Technology

2011-01-01

Minimum Error Bounded Efficient `1 Tracker with Occlusion Detection Xue Mei\\ ∗ Haibin Ling† Yi Wu†[ Erik Blasch‡ Li Bai] \\Assembly Test Technology...proposed BPR-L1 tracker is tested on several challenging benchmark sequences involving chal- lenges such as occlusion and illumination changes. In all...point method de - pends on the value of the regularization parameter λ. In the experiments, we found that the total number of PCG is a few hundred. The

Outcomes of high-dose levofloxacin therapy remain bound to the levofloxacin minimum inhibitory concentration in complicated urinary tract infections.

PubMed

Armstrong, Eliana S; Mikulca, Janelle A; Cloutier, Daniel J; Bliss, Caleb A; Steenbergen, Judith N

2016-11-25

Fluoroquinolones are a guideline-recommended therapy for complicated urinary tract infections, including pyelonephritis. Elevated drug concentrations of fluoroquinolones in the urine and therapy with high-dose levofloxacin are believed to overcome resistance and effectively treat infections caused by resistant bacteria. The ASPECT-cUTI phase 3 clinical trial (ClinicalTrials.gov, NCT01345929 and NCT01345955 , both registered April 28, 2011) provided an opportunity to test this hypothesis by examining the clinical and microbiological outcomes of high-dose levofloxacin treatment by levofloxacin minimum inhibitory concentration. Patients were randomly assigned 1:1 to ceftolozane/tazobactam (1.5 g intravenous every 8 h) or levofloxacin (750 mg intravenous once daily) for 7 days of therapy. The ASPECT-cUTI study provided data on 370 patients with at least one isolate of Enterobacteriaceae at baseline who were treated with levofloxacin. Outcomes were assessed at the test-of-cure (5-9 days after treatment) and late follow-up (21-42 days after treatment) visits in the microbiologically evaluable population (N = 327). Test-of-cure clinical cure rates above 90% were observed at minimum inhibitory concentrations ≤4 μg/mL. Microbiological eradication rates were consistently >90% at levofloxacin minimum inhibitory concentrations ≤0.06 μg/mL. Lack of eradication of causative pathogens at the test-of-cure visit increased the likelihood of relapse by the late follow-up visit. Results from this study do not support levofloxacin therapy for complicated urinary tract infections caused by organisms with levofloxacin minimum inhibitory concentrations ≥4 μg/mL. ClinicalTrials.gov, NCT01345929 and NCT01345955.

A new surgical technique for medial collateral ligament balancing: multiple needle puncturing.

PubMed

Bellemans, Johan; Vandenneucker, Hilde; Van Lauwe, Johan; Victor, Jan

2010-10-01

In this article, we present our experience with a new technique for medial soft tissue balancing, where we make multiple punctures in the medial collateral ligament (MCL) using a 19-gauge needle, to progressively stretch the MCL until a correct ligament balance is achieved. Ligament status was evaluated both before and after the procedure using computer navigation and mediolateral stress testing. The procedure was considered successful when 2 to 4-mm mediolateral joint line opening was obtained in extension and 2 to 6 mm in flexion. In 34 of 35 cases, a progressive correction of medial tightness was achieved according to the above described criteria. One case was considered overreleased in extension. Needle puncturing is a new, effective, and safe technique for progressive correction of MCL tightness in the varus knee. Copyright © 2010 Elsevier Inc. All rights reserved.

Development of High vacuum facility for baking and cool down experiments for SST-1 Tokamak components

NASA Astrophysics Data System (ADS)

Khan, Ziauddin; Pathan, Firozkhan S.; Yuvakiran, Paravastu; George, Siju; Manthena, Himabindu; Raval, Dilip C.; Thankey, Prashant L.; Dhanani, Kalpesh R.; Gupta, Manoj Kumar; Pradhan, Subrata

2012-11-01

SST-1 Tokamak, a steady state super-conducting device, is under refurbishment to demonstrate the plasma discharge for the duration of 1000 second. The major fabricated components of SST-1 like vacuum vessel, thermal shields, superconducting magnets etc have to be tested for their functional parameters. During machine operation, vacuum vessel will be baked at 150 °C, thermal shields will be operated at 85 K and magnet system will be operated at 4.5 K. All these components must have helium leak tightness under these conditions so far as the machine operation is concerned. In order to validate the helium leak tightness of these components, in-house high vacuum chamber is fabricated. This paper describes the analysis, design and fabrication of high vacuum chamber to demonstrate these functionalities. Also some results will be presented.

40 CFR 61.356 - Recordkeeping requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... test protocol and the means by which sampling variability and analytical variability were accounted for... also establish the design minimum and average temperature in the combustion zone and the combustion... the design minimum and average temperatures across the catalyst bed inlet and outlet. (C) For a boiler...

25 CFR 547.11 - What are the minimum technical standards for money and credit handling?

Code of Federal Regulations, 2010 CFR

2010-04-01

... GAMES § 547.11 What are the minimum technical standards for money and credit handling? This section... interface is: (i) Involved in the play of a game; (ii) In audit mode, recall mode or any test mode; (iii...

25 CFR 547.11 - What are the minimum technical standards for money and credit handling?

Code of Federal Regulations, 2012 CFR

2012-04-01

... GAMES § 547.11 What are the minimum technical standards for money and credit handling? This section... interface is: (i) Involved in the play of a game; (ii) In audit mode, recall mode or any test mode; (iii...

25 CFR 547.11 - What are the minimum technical standards for money and credit handling?

Code of Federal Regulations, 2011 CFR

2011-04-01

... GAMES § 547.11 What are the minimum technical standards for money and credit handling? This section... interface is: (i) Involved in the play of a game; (ii) In audit mode, recall mode or any test mode; (iii...

30 CFR 18.97 - Inspection of machines; minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Field Approval of Electrically Operated Mining Equipment § 18.97 Inspection of machines; minimum... shall be conducted by an electrical representative and such inspection shall include: (1) Examination of...

30 CFR 18.97 - Inspection of machines; minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Field Approval of Electrically Operated Mining Equipment § 18.97 Inspection of machines; minimum... shall be conducted by an electrical representative and such inspection shall include: (1) Examination of...

Gastrocnemius tightness on joint angle and work of lower extremity during gait.

PubMed

You, Jia-Yuan; Lee, Hsin-Min; Luo, Hong-Ji; Leu, Chwan-Chin; Cheng, Pen-Gang; Wu, Shyi-Kuen

2009-11-01

Muscular tightness is a common clinical musculoskeletal disorder and is regarded as a predisposing factor for muscle injuries. In this study, a two-way mixed design ANOVA was applied to investigate the effects of the gastrocnemius tightness on the joint angle and joint work during walking. Twenty-two patients with muscular tightness of gastrocnemius muscle (<12 degrees of ankle dorsiflexion with knee extended) and 22 age- and gender-matched subjects with normal gastrocnemius flexibility (>15 degrees of ankle dorsiflexion with knee extended) participated in this study. The joint angle and work at hip, knee, and ankle joints during the stance phase were analyzed at two preset cadences of 100 steps/min and 140 steps/min. Significantly greater flexion angles at hip (P=0.025) and knee (P=0.001) were found in the tightness group at the time of maximal ankle dorsiflexion. Significantly less work generation at knee (P=0.034) and greater work absorption at ankle (P=0.024) were detected in the tightness group. The subjects with gastrocnemius tightness revealed a compensatory gait pattern, which included the changes in the joint angles and associated work productions. The potential disturbance of the knee control and strain injuries of plantar flexors might be crucial in the clinical considerations for subjects with gastrocnemius tightness.

Comparison of the complementary feeding practices between mothers with twins and mothers with singletons.

PubMed

Bentil, Helena Joycelyn; Steiner-Asiedu, Matilda; Lartey, Anna

2016-01-01

Several studies have been done on infant feeding practices but few have focused on twins. The aim of this study was to compare the complementary feeding practices between mothers with twins and mothers with singletons. Mother-infant pairs (50 mother-twin pairs and 50 mother-singleton pairs) with children aged 6 to 23 months were recruited from two public health clinics and communities in Tema and Ashaiman. Information was collected on the background characteristics of the mothers. Recumbent length and weight of the children were measured. Dietary information on the infants was collected using 24 hour recall. The differences between two groups were tested using independent t-student test for continuous variables and chi-square test for categorical variables. The minimum dietary diversity (4+ food groups) was met by only 32% of the twins and 40% of the singletons, and 28% of the twins and 38% of the singletons met the requirement for minimum acceptable diet (minimum dietary diversity and the minimum meal frequency). Minimum meal frequency was met by 78% of the twins and 76% of the singletons. There were no significant differences between the two groups of infants. Prevalence of undernutrition was not significantly different among the two groups (twins versus singletons: underweight-26% versus 24%, stunting-20% versus 24% and wasting-14% versus 10%. Complementary feeding practices were suboptimal in both groups of mothers requiring interventions to improve infant feeding practices.

Adaptive tight frame based medical image reconstruction: a proof-of-concept study for computed tomography

NASA Astrophysics Data System (ADS)

Zhou, Weifeng; Cai, Jian-Feng; Gao, Hao

2013-12-01

A popular approach for medical image reconstruction has been through the sparsity regularization, assuming the targeted image can be well approximated by sparse coefficients under some properly designed system. The wavelet tight frame is such a widely used system due to its capability for sparsely approximating piecewise-smooth functions, such as medical images. However, using a fixed system may not always be optimal for reconstructing a variety of diversified images. Recently, the method based on the adaptive over-complete dictionary that is specific to structures of the targeted images has demonstrated its superiority for image processing. This work is to develop the adaptive wavelet tight frame method image reconstruction. The proposed scheme first constructs the adaptive wavelet tight frame that is task specific, and then reconstructs the image of interest by solving an l1-regularized minimization problem using the constructed adaptive tight frame system. The proof-of-concept study is performed for computed tomography (CT), and the simulation results suggest that the adaptive tight frame method improves the reconstructed CT image quality from the traditional tight frame method.

Measurement and Visualization of Tight Rock Exposed to CO2 Using NMR Relaxometry and MRI

PubMed Central

Wang, Haitao; Lun, Zengmin; Lv, Chengyuan; Lang, Dongjiang; Ji, Bingyu; Luo, Ming; Pan, Weiyi; Wang, Rui; Gong, Kai

2017-01-01

Understanding mechanisms of oil mobilization of tight matrix during CO2 injection is crucial for CO2 enhanced oil recovery (EOR) and sequestration engineering design. In this study exposure behavior between CO2 and tight rock of the Ordos Basin has been studied experimentally by using nuclear magnetic resonance transverse relaxation time (NMR T2) spectrum and magnetic resonance imaging (MRI) under the reservoir pressure and temperature. Quantitative analysis of recovery at the pore scale and visualization of oil mobilization are achieved. Effects of CO2 injection, exposure times and pressure on recovery performance have been investigated. The experimental results indicate that oil in all pores can be gradually mobilized to the surface of rock by CO2 injection. Oil mobilization in tight rock is time-consuming while oil on the surface of tight rock can be mobilized easily. CO2 injection can effectively mobilize oil in all pores of tight rock, especially big size pores. This understanding of process of matrix exposed to CO2 could support the CO2 EOR in tight reservoirs. PMID:28281697

A step-up test procedure to find the minimum effective dose.

PubMed

Wang, Weizhen; Peng, Jianan

2015-01-01

It is of great interest to find the minimum effective dose (MED) in dose-response studies. A sequence of decreasing null hypotheses to find the MED is formulated under the assumption of nondecreasing dose response means. A step-up multiple test procedure that controls the familywise error rate (FWER) is constructed based on the maximum likelihood estimators for the monotone normal means. When the MED is equal to one, the proposed test is uniformly more powerful than Hsu and Berger's test (1999). Also, a simulation study shows a substantial power improvement for the proposed test over four competitors. Three R-codes are provided in Supplemental Materials for this article. Go to the publishers online edition of Journal of Biopharmaceutical Statistics to view the files.

Results of qualification tests on water-level sensing instruments, 1987

USGS Publications Warehouse

Olive, T.E.

1989-01-01

The U.S. Geological Survey 's Hydrologic Instrumentation Facility at the Stennis Space Center, Mississippi, conducts qualification tests on water level sensing instruments. Instrument systems, which meet or exceed the Survey 's minimum performance requirements, are placed on the Survey 's Qualified Products List. The qualification tests conducted in 1987 added two instrument systems to the Survey 's Qualified Products List. One system met requirements for use at a daily-discharge station , and the other system met requirements for a special-case station. The report is prepared for users of hydrologic instruments. The report provides a list of instrument features, describes the instrument systems, summarizes test procedures, and presents test results for the two instrument systems that met the Survey 's minimum performance standards for the 1987 round of qualification tests. (USGS)

ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT: STORMWATER SOURCE AREA TREATMENT DEVICE — BAYSAVER TECHNOLOGIES, INC. BAYSAVER SEPARATION SYSTEM, MODEL 10K

EPA Science Inventory

Verification testing of the BaySaver Separation System, Model 10K was conducted on a 10 acre drainage basin near downtown Griffin, Georgia. The system consists of two water tight pre-cast concrete manholes and a high-density polyethylene BaySaver Separator Unit. The BaySaver Mod...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Morris, J.R.; Lu, Z.Y.; Xiang, J.B.

We have examined a variety of structures for the (510) symmetric tilt boundary in Si, using first-principles calculations. These calculations show that the observed structure in Si is the lowest energy structure. This structure is more complicated than what is necessary to preserve four-fold coordination. We compare the results to classical and tight-binding models, in order to test these empirical problems.

Business-Led Coalitions: Aligning Supply and Demand in Workforce Development. Workforce Brief #9.

ERIC Educational Resources Information Center

Mitchell, Stephen M.; Jimenez, Manuel

The test for today's economy is to create a workforce development system that capitalizes on current opportunities across states, regions, and local communities. The economic environment is positive, with tight, dynamic, and global labor markets. The business need for job-ready, entry-level workers; high-skilled workers; and workers who can…

Safely splicing glass optical fibers

NASA Technical Reports Server (NTRS)

Korbelak, K.

1980-01-01

Field-repair technique fuses glass fibers in flammable environment. Apparatus consists of v-groove vacuum chucks on manipulators, high-voltage dc power supply and tungsten electrodes, microscope to observe joint alignment and fusion, means of test transmission through joint. Apparatus is enclosed in gas tight bos filled with inert gas during fusion. About 2 feet of fiber end are necessary for splicing.

High-speed pressure clamp.

PubMed

Besch, Stephen R; Suchyna, Thomas; Sachs, Frederick

2002-10-01

We built a high-speed, pneumatic pressure clamp to stimulate patch-clamped membranes mechanically. The key control element is a newly designed differential valve that uses a single, nickel-plated piezoelectric bending element to control both pressure and vacuum. To minimize response time, the valve body was designed with minimum dead volume. The result is improved response time and stability with a threefold decrease in actuation latency. Tight valve clearances minimize the steady-state air flow, permitting us to use small resonant-piston pumps to supply pressure and vacuum. To protect the valve from water contamination in the event of a broken pipette, an optical sensor detects water entering the valve and increases pressure rapidly to clear the system. The open-loop time constant for pressure is 2.5 ms for a 100-mmHg step, and the closed-loop settling time is 500-600 micros. Valve actuation latency is 120 micros. The system performance is illustrated for mechanically induced changes in patch capacitance.

Stacked endoplasmic reticulum sheets are connected by helicoidal membrane motifs.

PubMed

Terasaki, Mark; Shemesh, Tom; Kasthuri, Narayanan; Klemm, Robin W; Schalek, Richard; Hayworth, Kenneth J; Hand, Arthur R; Yankova, Maya; Huber, Greg; Lichtman, Jeff W; Rapoport, Tom A; Kozlov, Michael M

2013-07-18

The endoplasmic reticulum (ER) often forms stacked membrane sheets, an arrangement that is likely required to accommodate a maximum of membrane-bound polysomes for secretory protein synthesis. How sheets are stacked is unknown. Here, we used improved staining and automated ultrathin sectioning electron microscopy methods to analyze stacked ER sheets in neuronal cells and secretory salivary gland cells of mice. Our results show that stacked ER sheets form a continuous membrane system in which the sheets are connected by twisted membrane surfaces with helical edges of left- or right-handedness. The three-dimensional structure of tightly stacked ER sheets resembles a parking garage, in which the different levels are connected by helicoidal ramps. A theoretical model explains the experimental observations and indicates that the structure corresponds to a minimum of elastic energy of sheet edges and surfaces. The structure allows the dense packing of ER sheets in the restricted space of a cell. Copyright © 2013 Elsevier Inc. All rights reserved.

Unsupervised image matching based on manifold alignment.

PubMed

Pei, Yuru; Huang, Fengchun; Shi, Fuhao; Zha, Hongbin

2012-08-01

This paper challenges the issue of automatic matching between two image sets with similar intrinsic structures and different appearances, especially when there is no prior correspondence. An unsupervised manifold alignment framework is proposed to establish correspondence between data sets by a mapping function in the mutual embedding space. We introduce a local similarity metric based on parameterized distance curves to represent the connection of one point with the rest of the manifold. A small set of valid feature pairs can be found without manual interactions by matching the distance curve of one manifold with the curve cluster of the other manifold. To avoid potential confusions in image matching, we propose an extended affine transformation to solve the nonrigid alignment in the embedding space. The comparatively tight alignments and the structure preservation can be obtained simultaneously. The point pairs with the minimum distance after alignment are viewed as the matchings. We apply manifold alignment to image set matching problems. The correspondence between image sets of different poses, illuminations, and identities can be established effectively by our approach.

Wind-Driven Formation of Ice Bridges in Straits.

PubMed

Rallabandi, Bhargav; Zheng, Zhong; Winton, Michael; Stone, Howard A

2017-03-24

Ice bridges are static structures composed of tightly packed sea ice that can form during the course of its flow through a narrow strait. Despite their important role in local ecology and climate, the formation and breakup of ice bridges is not well understood and has proved difficult to predict. Using long-wave approximations and a continuum description of sea ice dynamics, we develop a one-dimensional theory for the wind-driven formation of ice bridges in narrow straits, which is verified against direct numerical simulations. We show that for a given wind stress and minimum and maximum channel widths, a steady-state ice bridge can only form beyond a critical value of the thickness and the compactness of the ice field. The theory also makes quantitative predictions for ice fluxes, which are particularly useful to estimate the ice export associated with the breakup of ice bridges. We note that similar ideas are applicable to dense granular flows in confined geometries.

MAP Attitude Control System Design and Analysis

NASA Technical Reports Server (NTRS)

Andrews, S. F.; Campbell, C. E.; Ericsson-Jackson, A. J.; Markley, F. L.; ODonnell, J. R., Jr.

1997-01-01

The Microwave Anisotropy Probe (MAP) is a follow-on to the Differential Microwave Radiometer (DMR) instrument on the Cosmic Background Explorer (COBE) spacecraft. The MAP spacecraft will perform its mission in a Lissajous orbit around the Earth-Sun L(sub 2) Lagrange point to suppress potential instrument disturbances. To make a full-sky map of cosmic microwave background fluctuations, a combination fast spin and slow precession motion will be used. MAP requires a propulsion system to reach L(sub 2), to unload system momentum, and to perform stationkeeping maneuvers once at L(sub 2). A minimum hardware, power and thermal safe control mode must also be provided. Sufficient attitude knowledge must be provided to yield instrument pointing to a standard deviation of 1.8 arc-minutes. The short development time and tight budgets require a new way of designing, simulating, and analyzing the Attitude Control System (ACS). This paper presents the design and analysis of the control system to meet these requirements.

Mini-column assay for rapid detection of malachite green in fish.

PubMed

Shalaby, Ali R; Emam, Wafaa H; Anwar, Mervat M

2017-07-01

A simple, rapid and economical mini-column method for detecting malachite green (MG) residue in fish was developed. The method used a column with 2mm ID that was tightly packed with silica gel followed by alumina. Detection of MG was performed by viewing the developed mini-column at visible light by naked eye; where MG was seen as compact green band at the confluence of the silica gel layer with alumina layer. The limit of detection of the assay was 2ng which conform the minimum required performance limit (MRPL). Evaluation utility of the method indicated that all blank and spiked samples at levels below MRPL were assessed as accepted. The intensity of the green band increased whenever MG level in the extract increased; indicated that suggested mini-column technique could be used for semi-quantitative determination of MG in fish samples. The method can be used to select the questionable samples. Copyright © 2017 Elsevier Ltd. All rights reserved.

Human Protein-disulfide Isomerase Is a Redox-regulated Chaperone Activated by Oxidation of Domain a′*

PubMed Central

Wang, Chao; Yu, Jiang; Huo, Lin; Wang, Lei; Feng, Wei; Wang, Chih-chen

2012-01-01

Protein-disulfide isomerase (PDI), with domains arranged as abb′xa′c, is a key enzyme and chaperone localized in the endoplasmic reticulum (ER) catalyzing oxidative folding and preventing misfolding/aggregation of proteins. It has been controversial whether the chaperone activity of PDI is redox-regulated, and the molecular basis is unclear. Here, we show that both the chaperone activity and the overall conformation of human PDI are redox-regulated. We further demonstrate that the conformational changes are triggered by the active site of domain a′, and the minimum redox-regulated cassette is located in b′xa′. The structure of the reduced bb′xa′ reveals for the first time that domain a′ packs tightly with both domain b′ and linker x to form one compact structural module. Oxidation of domain a′ releases the compact conformation and exposes the shielded hydrophobic areas to facilitate its high chaperone activity. Thus, the study unequivocally provides mechanistic insights into the redox-regulated chaperone activity of human PDI. PMID:22090031

Development Requirements for Spacesuit Elbow Joint

NASA Technical Reports Server (NTRS)

Peters, Benjamin

2017-01-01

Functional Requirements for spacesuit elbow joint:1) The system is a conformal, single-axis spacesuit pressurized joint that encloses the elbow joint of the suited user and uses a defined interface to connect to the suit systems on either side of the joint.2) The system shall be designed to bear the loads incurred from the internal pressure of the system, as well as the expected loads induced by the user while enabling the user move the joint through the required range of motion. The joint torque of the system experienced by the user shall remain at or below the required specification for the entire range of motion.3) The design shall be constructed, at a minimum, as a two-layer system. The internal, air-tight layer shall be referred to as the bladder, and the layer on the unpressurized side of the bladder shall be referred to as the restraint. The design of the system may include additional features or layers, such as axial webbing, to meet the overall requirements of the design.

Minimum mass design of large-scale space trusses subjected to thermal gradients

NASA Technical Reports Server (NTRS)

Williams, R. Brett; Agnes, Gregory S.

2006-01-01

Lightweight, deployable trusses are commonly used to support space-borne instruments including RF reflectors, radar panels, and telescope optics. While in orbit, these support structures are subjected to thermal gradients that vary with altitude, location in orbit, and self-shadowing. Since these instruments have tight dimensional-stability requirements, their truss members are often covered with multi-layer insulation (MLI) blankets to minimize thermal distortions. This paper develops a radiation heat transfer model to predict the thermal gradient experienced by a triangular truss supporting a long, linear radar panel in Medium Earth Orbit (MEO). The influence of self-shadowing effects of the radar panel are included in the analysis, and the influence of both MLI thickness and outer covers/coatings on the magnitude of the thermal gradient are formed into a simple, two-dimensional analysis. This thermal model is then used to size and estimate the structural mass of a triangular truss that meets a given set of structural requirements.

Entropic uncertainty from effective anticommutators

NASA Astrophysics Data System (ADS)

Kaniewski, Jedrzej; Tomamichel, Marco; Wehner, Stephanie

2014-07-01

We investigate entropic uncertainty relations for two or more binary measurements, for example, spin-1/2 or polarization measurements. We argue that the effective anticommutators of these measurements, i.e., the anticommutators evaluated on the state prior to measuring, are an expedient measure of measurement incompatibility. Based on the knowledge of pairwise effective anticommutators we derive a class of entropic uncertainty relations in terms of conditional Rényi entropies. Our uncertainty relations are formulated in terms of effective measures of incompatibility, which can be certified in a device-independent fashion. Consequently, we discuss potential applications of our findings to device-independent quantum cryptography. Moreover, to investigate the tightness of our analysis we consider the simplest (and very well studied) scenario of two measurements on a qubit. We find that our results outperform the celebrated bound due to Maassen and Uffink [Phys. Rev. Lett. 60, 1103 (1988), 10.1103/PhysRevLett.60.1103] and provide an analytical expression for the minimum uncertainty which also outperforms some recent bounds based on majorization.

Relation between inflammables and ignition sources in aircraft environments

NASA Technical Reports Server (NTRS)

Scull, Wilfred E

1951-01-01

A literature survey was conducted to determine the relation between aircraft ignition sources and inflammables. Available literature applicable to the problem of aircraft fire hazards is analyzed and discussed. Data pertaining to the effect of many variables on ignition temperatures, minimum ignition pressures, minimum spark-ignition energies of inflammables, quenching distances of electrode configurations, and size of openings through which flame will not propagate are presented and discussed. Ignition temperatures and limits of inflammability of gasoline in air in different test environments, and the minimum ignition pressures and minimum size of opening for flame propagation in gasoline-air mixtures are included; inerting of gasoline-air mixtures is discussed.

Dielectric response of molecules in empirical tight-binding theory

NASA Astrophysics Data System (ADS)

Boykin, Timothy B.; Vogl, P.

2002-01-01

In this paper we generalize our previous approach to electromagnetic interactions within empirical tight-binding theory to encompass molecular solids and isolated molecules. In order to guarantee physically meaningful results, we rederive the expressions for relevant observables using commutation relations appropriate to the finite tight-binding Hilbert space. In carrying out this generalization, we examine in detail the consequences of various prescriptions for the position and momentum operators in tight binding. We show that attempting to fit parameters of the momentum matrix directly generally results in a momentum operator which is incompatible with the underlying tight-binding model, while adding extra position parameters results in numerous difficulties, including the loss of gauge invariance. We have applied our scheme, which we term the Peierls-coupling tight-binding method, to the optical dielectric function of the molecular solid PPP, showing that this approach successfully predicts its known optical properties even in the limit of isolated molecules.

40 CFR 63.1365 - Test methods and initial compliance procedures.

Code of Federal Regulations, 2013 CFR

2013-07-01

... design minimum and average temperature in the combustion zone and the combustion zone residence time. (B... establish the design minimum and average flame zone temperatures and combustion zone residence time, and... carbon bed temperature after regeneration, design carbon bed regeneration time, and design service life...

26 CFR 1.410(b)-6 - Excludable employees.

Code of Federal Regulations, 2011 CFR

2011-04-01

... section are applied by treating all plans in the testing group as a single plan. (b) Minimum age and... greatest permissible minimum age and service requirement because the ratio percentage of that group of...)-6 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX...

Decreased expression of zonula occludens-1 and occludin in the bladder urothelium of patients with interstitial cystitis/painful bladder syndrome.

PubMed

Lee, Jane-Dar; Lee, Ming-Huei

2014-01-01

Unique barrier properties of the urothelial surface membrane permit urine storage without contents leak into the bloodstream. Previous reports suggested that the bladder urothelial barrier might be compromised in interstitial cystitis/painful bladder syndrome (IC/PBS). We examined the changes of tight junction proteins (zonula occludens-1 (ZO-1) and occludin) in IC/PBS patients. Bladder samples were derived from of 32 patients with IC/PBS and eight controls. We detected the tight junction proteins of ZO-1 and occludin expression by immunoblotting, immunohistochemical (IHC) staining and double immunofluorescent (IF) staining with confocal microscopy. Data were analyzed using the Mann-Whitney U-test. Expression of ZO-1 and occludin in the IC/PBS group was reduced compared to the control group by immunoblotting and IHC staining. Also, the thinning and denudation of urothelium were demonstrated in the IC/PBS group by histological study. IF staining showed the interruption of bladder urothelium in IC/PBS patients under confocal microscopy. Our data showed that decreased expression of tight junction proteins (ZO-1 and occludin) and interruption of bladder urothelium in IC/PBS patients. Treatment to repair the discontinuous urothelium may be useful to relieve some clinical symptoms of patients with IC/PBS. Copyright © 2012. Published by Elsevier B.V.

Flow behavior of N2 huff and puff process for enhanced oil recovery in tight oil reservoirs.

PubMed

Lu, Teng; Li, Zhaomin; Li, Jian; Hou, Dawei; Zhang, Dingyong

2017-11-16

In the present work, the potential of N 2 huff and puff process to enhance the recovery of tight oil reservoir was evaluated. N 2 huff and puff experiments were performed in micromodels and cores to investigate the flow behaviors of different cycles. The results showed that, in the first cycle, N 2 was dispersed in the oil, forming the foamy oil flow. In the second cycle, the dispersed gas bubbles gradually coalesced into the continuous gas phase. In the third cycle, N 2 was produced in the form of continuous gas phase. The results from the coreflood tests showed that, the primary recovery was only 5.32%, while the recoveries for the three N 2 huff and puff cycles were 15.1%, 8.53% and 3.22%, respectively.The recovery and the pressure gradient in the first cycle were high. With the increase of huff and puff cycles, and the oil recovery and the pressure gradient rapidly decreased. The oil recovery of N 2 huff and puff has been found to increase as the N 2 injection pressure and the soaking time increased. These results showed that, the properly designed and controlled N 2 huff and puff process can lead to enhanced recovery of tight oil reservoirs.

Electronic Coupling Calculations for Bridge-Mediated Charge Transfer Using Constrained Density Functional Theory (CDFT) and Effective Hamiltonian Approaches at the Density Functional Theory (DFT) and Fragment-Orbital Density Functional Tight Binding (FODFTB) Level

DOE PAGES

Gillet, Natacha; Berstis, Laura; Wu, Xiaojing; ...

2016-09-09

In this paper, four methods to calculate charge transfer integrals in the context of bridge-mediated electron transfer are tested. These methods are based on density functional theory (DFT). We consider two perturbative Green's function effective Hamiltonian methods (first, at the DFT level of theory, using localized molecular orbitals; second, applying a tight-binding DFT approach, using fragment orbitals) and two constrained DFT implementations with either plane-wave or local basis sets. To assess the performance of the methods for through-bond (TB)-dominated or through-space (TS)-dominated transfer, different sets of molecules are considered. For through-bond electron transfer (ET), several molecules that were originally synthesizedmore » by Paddon-Row and co-workers for the deduction of electronic coupling values from photoemission and electron transmission spectroscopies, are analyzed. The tested methodologies prove to be successful in reproducing experimental data, the exponential distance decay constant and the superbridge effects arising from interference among ET pathways. For through-space ET, dedicated p-stacked systems with heterocyclopentadiene molecules were created and analyzed on the basis of electronic coupling dependence on donor-acceptor distance, structure of the bridge, and ET barrier height. The inexpensive fragment-orbital density functional tight binding (FODFTB) method gives similar results to constrained density functional theory (CDFT) and both reproduce the expected exponential decay of the coupling with donor-acceptor distances and the number of bridging units. Finally, these four approaches appear to give reliable results for both TB and TS ET and present a good alternative to expensive ab initio methodologies for large systems involving long-range charge transfers.« less

Electronic Coupling Calculations for Bridge-Mediated Charge Transfer Using Constrained Density Functional Theory (CDFT) and Effective Hamiltonian Approaches at the Density Functional Theory (DFT) and Fragment-Orbital Density Functional Tight Binding (FODFTB) Level

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gillet, Natacha; Berstis, Laura; Wu, Xiaojing

In this paper, four methods to calculate charge transfer integrals in the context of bridge-mediated electron transfer are tested. These methods are based on density functional theory (DFT). We consider two perturbative Green's function effective Hamiltonian methods (first, at the DFT level of theory, using localized molecular orbitals; second, applying a tight-binding DFT approach, using fragment orbitals) and two constrained DFT implementations with either plane-wave or local basis sets. To assess the performance of the methods for through-bond (TB)-dominated or through-space (TS)-dominated transfer, different sets of molecules are considered. For through-bond electron transfer (ET), several molecules that were originally synthesizedmore » by Paddon-Row and co-workers for the deduction of electronic coupling values from photoemission and electron transmission spectroscopies, are analyzed. The tested methodologies prove to be successful in reproducing experimental data, the exponential distance decay constant and the superbridge effects arising from interference among ET pathways. For through-space ET, dedicated p-stacked systems with heterocyclopentadiene molecules were created and analyzed on the basis of electronic coupling dependence on donor-acceptor distance, structure of the bridge, and ET barrier height. The inexpensive fragment-orbital density functional tight binding (FODFTB) method gives similar results to constrained density functional theory (CDFT) and both reproduce the expected exponential decay of the coupling with donor-acceptor distances and the number of bridging units. Finally, these four approaches appear to give reliable results for both TB and TS ET and present a good alternative to expensive ab initio methodologies for large systems involving long-range charge transfers.« less

Electronic Coupling Calculations for Bridge-Mediated Charge Transfer Using Constrained Density Functional Theory (CDFT) and Effective Hamiltonian Approaches at the Density Functional Theory (DFT) and Fragment-Orbital Density Functional Tight Binding (FODFTB) Level.

PubMed

Gillet, Natacha; Berstis, Laura; Wu, Xiaojing; Gajdos, Fruzsina; Heck, Alexander; de la Lande, Aurélien; Blumberger, Jochen; Elstner, Marcus

2016-10-11

In this article, four methods to calculate charge transfer integrals in the context of bridge-mediated electron transfer are tested. These methods are based on density functional theory (DFT). We consider two perturbative Green's function effective Hamiltonian methods (first, at the DFT level of theory, using localized molecular orbitals; second, applying a tight-binding DFT approach, using fragment orbitals) and two constrained DFT implementations with either plane-wave or local basis sets. To assess the performance of the methods for through-bond (TB)-dominated or through-space (TS)-dominated transfer, different sets of molecules are considered. For through-bond electron transfer (ET), several molecules that were originally synthesized by Paddon-Row and co-workers for the deduction of electronic coupling values from photoemission and electron transmission spectroscopies, are analyzed. The tested methodologies prove to be successful in reproducing experimental data, the exponential distance decay constant and the superbridge effects arising from interference among ET pathways. For through-space ET, dedicated π-stacked systems with heterocyclopentadiene molecules were created and analyzed on the basis of electronic coupling dependence on donor-acceptor distance, structure of the bridge, and ET barrier height. The inexpensive fragment-orbital density functional tight binding (FODFTB) method gives similar results to constrained density functional theory (CDFT) and both reproduce the expected exponential decay of the coupling with donor-acceptor distances and the number of bridging units. These four approaches appear to give reliable results for both TB and TS ET and present a good alternative to expensive ab initio methodologies for large systems involving long-range charge transfers.

Simulation Propulsion System and Trajectory Optimization

NASA Technical Reports Server (NTRS)

Hendricks, Eric S.; Falck, Robert D.; Gray, Justin S.

2017-01-01

A number of new aircraft concepts have recently been proposed which tightly couple the propulsion system design and operation with the overall vehicle design and performance characteristics. These concepts include propulsion technology such as boundary layer ingestion, hybrid electric propulsion systems, distributed propulsion systems and variable cycle engines. Initial studies examining these concepts have typically used a traditional decoupled approach to aircraft design where the aerodynamics and propulsion designs are done a-priori and tabular data is used to provide inexpensive look ups to the trajectory ana-ysis. However the cost of generating the tabular data begins to grow exponentially when newer aircraft concepts require consideration of additional operational parameters such as multiple throttle settings, angle-of-attack effects on the propulsion system, or propulsion throttle setting effects on aerodynamics. This paper proposes a new modeling approach that eliminated the need to generate tabular data, instead allowing an expensive propulsion or aerodynamic analysis to be directly integrated into the trajectory analysis model and the entire design problem optimized in a fully coupled manner. The new method is demonstrated by implementing a canonical optimal control problem, the F-4 minimum time-to-climb trajectory optimization using three relatively new analysis tools: Open M-DAO, PyCycle and Pointer. Pycycle and Pointer both provide analytic derivatives and Open MDAO enables the two tools to be combined into a coupled model that can be run in an efficient parallel manner that helps to cost the increased cost of the more expensive propulsion analysis. Results generated with this model serve as a validation of the tightly coupled design method and guide future studies to examine aircraft concepts with more complex operational dependencies for the aerodynamic and propulsion models.

Automated clustering-based workload characterization

NASA Technical Reports Server (NTRS)

Pentakalos, Odysseas I.; Menasce, Daniel A.; Yesha, Yelena

1996-01-01

The demands placed on the mass storage systems at various federal agencies and national laboratories are continuously increasing in intensity. This forces system managers to constantly monitor the system, evaluate the demand placed on it, and tune it appropriately using either heuristics based on experience or analytic models. Performance models require an accurate workload characterization. This can be a laborious and time consuming process. It became evident from our experience that a tool is necessary to automate the workload characterization process. This paper presents the design and discusses the implementation of a tool for workload characterization of mass storage systems. The main features of the tool discussed here are: (1)Automatic support for peak-period determination. Histograms of system activity are generated and presented to the user for peak-period determination; (2) Automatic clustering analysis. The data collected from the mass storage system logs is clustered using clustering algorithms and tightness measures to limit the number of generated clusters; (3) Reporting of varied file statistics. The tool computes several statistics on file sizes such as average, standard deviation, minimum, maximum, frequency, as well as average transfer time. These statistics are given on a per cluster basis; (4) Portability. The tool can easily be used to characterize the workload in mass storage systems of different vendors. The user needs to specify through a simple log description language how the a specific log should be interpreted. The rest of this paper is organized as follows. Section two presents basic concepts in workload characterization as they apply to mass storage systems. Section three describes clustering algorithms and tightness measures. The following section presents the architecture of the tool. Section five presents some results of workload characterization using the tool.Finally, section six presents some concluding remarks.

Electrical design of InAs-Sb/GaSb superlattices for optical detectors using full bandstructure sp3s* tight-binding method and Bloch boundary conditions

NASA Astrophysics Data System (ADS)

Mir, Raja N.; Frensley, William R.

2013-10-01

InAs-Sb/GaSb type-II strain compensated superlattices (SLS) are currently being used in mid-wave and long-wave infrared photodetectors. The electronic bandstructure of InSb and GaSb shows very strong anisotropy and non-parabolicity close to the Γ-point for the conduction band (CB) minimum and the valence band (VB) maximum. Particularly around the energy range of 45-80 meV from band-edge we observe strong non-parabolicity in the CB and light hole VB. The band-edge dispersion determines the electrical properties of a material. When the bulk materials are combined to form a superlattice we need a model of bandstructure which takes into account the full bandstructure details of the constituents and also the strong interaction between the conduction band of InAs and valence bands of GaSb. There can also be contact potentials near the interface between two dissimilar superlattices which will not be captured unless a full bandstructure calculation is done. In this study, we have done a calculation using second nearest neighbor tight binding model in order to accurately reproduce the effective masses. The calculation of mini-band structure is done by finding the wavefunctions within one SL period subject to Bloch boundary conditions ψ(L)=ψ(0)eikL. We demonstrate in this paper how a calculation of carrier concentration as a function of the position of the Fermi level (EF) within bandgap(Eg) should be done in order to take into account the full bandstructure of broken-bandgap material systems. This calculation is key for determining electron transport particularly when we have an interface between two dissimilar superlattices.

How actin binds and assembles onto plasma membranes from Dictyostelium discoideum

PubMed Central

1988-01-01

We have shown previously (Schwartz, M. A., and E. J. Luna. 1986. J. Cell Biol. 102: 2067-2075) that actin binds with positive cooperativity to plasma membranes from Dictyostelium discoideum. Actin is polymerized at the membrane surface even at concentrations well below the critical concentration for polymerization in solution. Low salt buffer that blocks actin polymerization in solution also prevents actin binding to membranes. To further explore the relationship between actin polymerization and binding to membranes, we prepared four chemically modified actins that appear to be incapable of polymerizing in solution. Three of these derivatives also lost their ability to bind to membranes. The fourth derivative (EF actin), in which histidine-40 is labeled with ethoxyformic anhydride, binds to membranes with reduced affinity. Binding curves exhibit positive cooperativity, and cross- linking experiments show that membrane-bound actin is multimeric. Thus, binding and polymerization are tightly coupled, and the ability of these membranes to polymerize actin is dramatically demonstrated. EF actin coassembles weakly with untreated actin in solution, but coassembles well on membranes. Binding by untreated actin and EF actin are mutually competitive, indicating that they bind to the same membrane sites. Hill plots indicate that an actin trimer is the minimum assembly state required for tight binding to membranes. The best explanation for our data is a model in which actin oligomers assemble by binding to clustered membrane sites with successive monomers on one side of the actin filament bound to the membrane. Individual binding affinities are expected to be low, but the overall actin-membrane avidity is high, due to multivalency. Our results imply that extracellular factors that cluster membrane proteins may create sites for the formation of actin nuclei and thus trigger actin polymerization in the cell. PMID:3392099

Tight-binding molecular-dynamics study of point defects in GaAs

NASA Astrophysics Data System (ADS)

Seong, Hyangsuk; Lewis, Laurent J.

1995-08-01

Tight-binding molecular-dynamics simulations at 0 K have been performed in order to study the effect of defects (vacancies and antisites) in different states of charge on the electronic and structural properties of GaAs. Relaxations are fully included in the model, and for each defect we calculate the local atomic structure, the volume change upon relaxing, the formation energy (including chemical potential contributions), and the ionization levels. We find Ga vacancies to relax by an amount which is independent of the state of charge, consistent with positron lifetime measurements. Our calculations also predict Ga vacancies to exhibit a negative-U effect, and to assume a triply negative charge state for most values of the electron chemical potential. The relaxation of As vacancies, on the contrary, depends sensitively on the state of charge. The model confirms the two experimentally observed ionization levels for this defect, just below the conduction-band minimum. Likewise, Ga antisites exhibit large relaxations. In fact, in the neutral state, relaxation is so large that it leads to a ``broken-bond'' configuration, in excellent accord with the first-principles calculations of Zhang and Chadi [Phys. Rev. Lett. 64, 1789 (1990)]. This system also exhibits a negative-U effect, for values of the electron chemical potential near midgap. For As antisites, we find only a weak relaxation, independent of the charge. The model predicts the neutral state of the defect to be the ground state for values of the electron chemical potential near and above midgap, which supports the view that the EL2 defect is a neutral As antisite. Upon comparing the formation energies of the various defects we finally find that, for all values of the atomic chemical potentials, antisites are most likely to occur than vacancies.

Determining the minimum in situ stress from hydraulic fracturing through perforations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Warpinski, N.R.

Hydraulic fracture stress measurements have been performed through perforations at depths from 1310 to 2470 m at the US Department of Energy's Multiwell Experiment site. The results of over sixty stress tests conducted through perforations have shown that small-volume hydraulic fractures generally provide an accurate, reproducible measurement of the minimum in situ stress. However, unusual behavior can occur in some tests and techniques to evaluate the behavior are suggested. Unclear instantaneous shut-in pressures, which are found on occasional tests, are difficult to evaluate, but the problem appears to be a complex stress state; reprocessing the data using log-log or othermore » functions does not necessarily provide the correct stress value. The possible error in such tests should be assessed from the original pressure-time data and not the reprocessing techniques. Stress results show that the stress distribution is dependent on lithology at this site; mudstones, shales and other nonreservoir rocks generally have a near-lithostatic stress, while sandstones have a considerably lower minimum stress value. 30 refs., 18 figs., 4 tabs.« less

Experimental instrumentation system for the Phased Array Mirror Extendible Large Aperture (PAMELA) test program

NASA Technical Reports Server (NTRS)

Boykin, William H., Jr.

1993-01-01

Adaptive optics are used in telescopes for both viewing objects with minimum distortion and for transmitting laser beams with minimum beam divergence and dance. In order to test concepts on a smaller scale, NASA MSFC is in the process of setting up an adaptive optics test facility with precision (fraction of wavelengths) measurement equipment. The initial system under test is the adaptive optical telescope called PAMELA (Phased Array Mirror Extendible Large Aperture). Goals of this test are: assessment of test hardware specifications for PAMELA application and the determination of the sensitivities of instruments for measuring PAMELA (and other adaptive optical telescopes) imperfections; evaluation of the PAMELA system integration effort and test progress and recommended actions to enhance these activities; and development of concepts and prototypes of experimental apparatuses for PAMELA.

On the testing of Hardy-Weinberg proportions and equality of allele frequencies in males and females at biallelic genetic markers.

PubMed

Graffelman, Jan; Weir, Bruce S

2018-02-01

Standard statistical tests for equality of allele frequencies in males and females and tests for Hardy-Weinberg equilibrium are tightly linked by their assumptions. Tests for equality of allele frequencies assume Hardy-Weinberg equilibrium, whereas the usual chi-square or exact test for Hardy-Weinberg equilibrium assume equality of allele frequencies in the sexes. In this paper, we propose ways to break this interdependence in assumptions of the two tests by proposing an omnibus exact test that can test both hypotheses jointly, as well as a likelihood ratio approach that permits these phenomena to be tested both jointly and separately. The tests are illustrated with data from the 1000 Genomes project. © 2017 The Authors Genetic Epidemiology Published by Wiley Periodicals, Inc.

Comparison of effects of static, proprioceptive neuromuscular facilitation and Mulligan stretching on hip flexion range of motion: a randomized controlled trial.

PubMed

Yıldırım, M S; Ozyurek, S; Tosun, Oç; Uzer, S; Gelecek, N

2016-03-01

The aim of this study was to compare the effects of static stretching, proprioceptive neuromuscular facilitation (PNF) stretching and Mulligan technique on hip flexion range of motion (ROM) in subjects with bilateral hamstring tightness. A total of 40 students (mean age: 21.5±1.3 years, mean body height: 172.8±8.2 cm, mean body mass index: 21.9±3.0 kg · m(-2)) with bilateral hamstring tightness were enrolled in this randomized trial, of whom 26 completed the study. Subjects were divided into 4 groups performing (I) typical static stretching, (II) PNF stretching, (III) Mulligan traction straight leg raise (TSLR) technique, (IV) no intervention. Hip flexion ROM was measured using a digital goniometer with the passive straight leg raise test before and after 4 weeks by two physiotherapists blinded to the groups. 52 extremities of 26 subjects were analyzed. Hip flexion ROM increased in all three intervention groups (p<0.05) but not in the no-intervention group after 4 weeks. A statistically significant change in initial-final assessment differences of hip flexion ROM was found between groups (p<0.001) in favour of PNF stretching and Mulligan TSLR technique in comparison to typical static stretching (p=0.016 and p=0.02, respectively). No significant difference was found between Mulligan TSLR technique and PNF stretching (p=0.920). The initial-final assessment difference of hip flexion ROM was similar in typical static stretching and no intervention (p=0.491). A 4-week stretching intervention is beneficial for increasing hip flexion ROM in bilateral hamstring tightness. However, PNF stretching and Mulligan TSLR technique are superior to typical static stretching. These two interventions can be alternatively used for stretching in hamstring tightness.

Comparison of effects of static, proprioceptive neuromuscular facilitation and Mulligan stretching on hip flexion range of motion: a randomized controlled trial

PubMed Central

Ozyurek, S; Tosun, OÇ; Uzer, S; Gelecek, N

2016-01-01

The aim of this study was to compare the effects of static stretching, proprioceptive neuromuscular facilitation (PNF) stretching and Mulligan technique on hip flexion range of motion (ROM) in subjects with bilateral hamstring tightness. A total of 40 students (mean age: 21.5±1.3 years, mean body height: 172.8±8.2 cm, mean body mass index: 21.9±3.0 kg · m-2) with bilateral hamstring tightness were enrolled in this randomized trial, of whom 26 completed the study. Subjects were divided into 4 groups performing (I) typical static stretching, (II) PNF stretching, (III) Mulligan traction straight leg raise (TSLR) technique, (IV) no intervention. Hip flexion ROM was measured using a digital goniometer with the passive straight leg raise test before and after 4 weeks by two physiotherapists blinded to the groups. 52 extremities of 26 subjects were analyzed. Hip flexion ROM increased in all three intervention groups (p<0.05) but not in the no-intervention group after 4 weeks. A statistically significant change in initial–final assessment differences of hip flexion ROM was found between groups (p<0.001) in favour of PNF stretching and Mulligan TSLR technique in comparison to typical static stretching (p=0.016 and p=0.02, respectively). No significant difference was found between Mulligan TSLR technique and PNF stretching (p=0.920). The initial–final assessment difference of hip flexion ROM was similar in typical static stretching and no intervention (p=0.491). A 4-week stretching intervention is beneficial for increasing hip flexion ROM in bilateral hamstring tightness. However, PNF stretching and Mulligan TSLR technique are superior to typical static stretching. These two interventions can be alternatively used for stretching in hamstring tightness. PMID:26929476

In situ stress and pore pressure in the Kumano Forearc Basin, offshore SW Honshu from downhole measurements during riser drilling

NASA Astrophysics Data System (ADS)

Saffer, D. M.; Flemings, P. B.; Boutt, D.; Doan, M.-L.; Ito, T.; McNeill, L.; Byrne, T.; Conin, M.; Lin, W.; Kano, Y.; Araki, E.; Eguchi, N.; Toczko, S.

2013-05-01

situ stress and pore pressure are key parameters governing rock deformation, yet direct measurements of these quantities are rare. During Integrated Ocean Drilling Program (IODP) Expedition #319, we drilled through a forearc basin at the Nankai subduction zone and into the underlying accretionary prism. We used the Modular Formation Dynamics Tester tool (MDT) for the first time in IODP to measure in situ minimum stress, pore pressure, and permeability at 11 depths between 729.9 and 1533.9 mbsf. Leak-off testing at 708.6 mbsf conducted as part of drilling operations provided a second measurement of minimum stress. The MDT campaign included nine single-probe (SP) tests to measure permeability and in situ pore pressure and two dual-packer (DP) tests to measure minimum principal stress. Permeabilities defined from the SP tests range from 6.53 × 10-17 to 4.23 × 10-14 m2. Pore fluid pressures are near hydrostatic throughout the section despite rapid sedimentation. This is consistent with the measured hydraulic diffusivity of the sediments and suggests that the forearc basin should not trap overpressures within the upper plate of the subduction zone. Minimum principal stresses are consistently lower than the vertical stress. We estimate the maximum horizontal stress from wellbore failures at the leak-off test and shallow MDT DP test depths. The results indicate a normal or strike-slip stress regime, consistent with the observation of abundant active normal faults in the seaward-most part of the basin, and a general decrease in fault activity in the vicinity of Site C0009.

Tight Bounds for Minimax Grid Matching, with Applications to the Average Case Analysis of Algorithms.

DTIC Science & Technology

1986-05-01

AD-ft?l 552 TIGHT BOUNDS FOR NININAX GRID MATCHING WITH i APPLICATIONS TO THE AVERAGE C.. (U) MASSACHUSETTS INST OF TECH CAMBRIDGE LAS FOR COMPUTER...MASSACHUSETTS LABORATORYFORNSTITUTE OF COMPUTER SCIENCE TECHNOLOGY MIT/LCS/TM-298 TIGHT BOUNDS FOR MINIMAX GRID MATCHING, WITH APPLICATIONS TO THE AVERAGE...PERIOD COVERED Tight bounds for minimax grid matching, Interim research with applications to the average case May 1986 analysis of algorithms. 6

Plant-derived triterpene celastrol ameliorates oxygen glucose deprivation-induced disruption of endothelial barrier assembly via inducing tight junction proteins.

PubMed

Luo, Dan; Zhao, Jia; Rong, Jianhui

2016-12-01

The integrity and functions of blood-brain barrier (BBB) are regulated by the expression and organization of tight junction proteins. The present study was designed to explore whether plant-derived triterpenoid celastrol could regulate tight junction integrity in murine brain endothelial bEnd3 cells. We disrupted the tight junctions between endothelial bEnd3 cells by oxygen glucose deprivation (OGD). We investigated the effects of celastrol on the permeability of endothelial monolayers by measuring transepithelial electrical resistance (TEER). To clarify the tight junction composition, we analyzed the expression of tight junction proteins by RT-PCR and Western blotting techniques. We found that celastrol recovered OGD-induced TEER loss in a concentration-dependent manner. Celastrol induced occludin, claudin-5 and zonula occludens-1 (ZO-1) in endothelial cells. As a result, celastrol effectively maintained tight junction integrity and inhibited macrophage migration through endothelial monolayers against OGD challenge. Further mechanistic studies revealed that celastrol induced the expression of occludin and ZO-1) via activating MAPKs and PI3K/Akt/mTOR pathway. We also observed that celastrol regulated claudin-5 expression through different mechanisms. The present study demonstrated that celastrol effectively protected tight junction integrity against OGD-induced damage. Thus, celastrol could be a drug candidate for the treatment of BBB dysfunction in various diseases. Copyright © 2016 Elsevier GmbH. All rights reserved.

Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease.

PubMed

Lerner, Aaron; Matthias, Torsten

2015-06-01

The incidence of autoimmune diseases is increasing along with the expansion of industrial food processing and food additive consumption. The intestinal epithelial barrier, with its intercellular tight junction, controls the equilibrium between tolerance and immunity to non-self-antigens. As a result, particular attention is being placed on the role of tight junction dysfunction in the pathogenesis of AD. Tight junction leakage is enhanced by many luminal components, commonly used industrial food additives being some of them. Glucose, salt, emulsifiers, organic solvents, gluten, microbial transglutaminase, and nanoparticles are extensively and increasingly used by the food industry, claim the manufacturers, to improve the qualities of food. However, all of the aforementioned additives increase intestinal permeability by breaching the integrity of tight junction paracellular transfer. In fact, tight junction dysfunction is common in multiple autoimmune diseases and the central part played by the tight junction in autoimmune diseases pathogenesis is extensively described. It is hypothesized that commonly used industrial food additives abrogate human epithelial barrier function, thus, increasing intestinal permeability through the opened tight junction, resulting in entry of foreign immunogenic antigens and activation of the autoimmune cascade. Future research on food additives exposure-intestinal permeability-autoimmunity interplay will enhance our knowledge of the common mechanisms associated with autoimmune progression. Copyright © 2015. Published by Elsevier B.V.

40 CFR 600.010-86 - Vehicle test requirements and minimum data requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... additional model types established under § 600.207(a)(2), data from each subconfiguration included within the... data requirements. 600.010-86 Section 600.010-86 Protection of Environment ENVIRONMENTAL PROTECTION... requirements and minimum data requirements. (a) For each certification vehicle defined in this part, and for...

9 CFR 130.30 - Hourly rate and minimum user fees.

Code of Federal Regulations, 2010 CFR

2010-01-01

... food testing. (16) Export-related services provided at animal auctions. (17) Various export-related... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Hourly rate and minimum user fees. 130.30 Section 130.30 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT...

High School Graduation Minimum Competency Requirements. Final Technical Report.

ERIC Educational Resources Information Center

Austin Independent School District, TX. Office of Research and Evaluation.

This technical report details the testing results and analyses supporting the evaluation findings related to the Austin (Texas) Independent School District (AISD) minimum competency graduation requirements. The graduation competency status of all AISD students in grades 8 to 12 are documented. The report provides additional information on the data…

Establishing Proficiency Standards for High School Graduation.

ERIC Educational Resources Information Center

Herron, Marshall D.

The Oregon State Board of Education has rejected the use of cut-off scores on a proficiency test to establish minimum performance standards for high school graduation. Instead, each school district is required to specify--by local board adoption--minimum competencies in reading, writing, listening, speaking, analyzing, and computing. These…

9 CFR 147.51 - Authorized laboratory minimum requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Authorized laboratory minimum requirements. 147.51 Section 147.51 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE.... The testing procedures at the laboratory must be run or overseen by a laboratory technician who has...

9 CFR 147.51 - Authorized laboratory minimum requirements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Authorized laboratory minimum requirements. 147.51 Section 147.51 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE.... The testing procedures at the laboratory must be run or overseen by a laboratory technician who has...

9 CFR 147.51 - Authorized laboratory minimum requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Authorized laboratory minimum requirements. 147.51 Section 147.51 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE.... The testing procedures at the laboratory must be run or overseen by a laboratory technician who has...

9 CFR 147.51 - Authorized laboratory minimum requirements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Authorized laboratory minimum requirements. 147.51 Section 147.51 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE.... The testing procedures at the laboratory must be run or overseen by a laboratory technician who has...

9 CFR 147.51 - Authorized laboratory minimum requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Authorized laboratory minimum requirements. 147.51 Section 147.51 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE.... The testing procedures at the laboratory must be run or overseen by a laboratory technician who has...