Abstract ID: 242 Simulation of a Fast Timing Micro-Pattern Gaseous Detector for TOF-PET.

PubMed

Radogna, Raffaella; Verwilligen, Piet

2018-01-01

Micro-Pattern Gas Detectors (MPGDs) are a new generation of gaseous detectors that have been developed thanks to advances in micro-structure technology. The main features of the MPGDs are: high rate capability (>50 MHz/cm 2 ); excellent spatial resolution (down to 50 μm); good time resolution (down to 3 ns); reduced radiation length, affordable costs, and possible flexible geometries. A new detector layout has been recently proposed that aims at combining both the high spatial resolution and high rate capability (100 MHz/cm 2 ) of the current state-of-the-art MPGDs with a high time resolution. This new type of MPGD is named the Fast Timing MPGD (FTM) detector [1,2]. The FTM developed for detecting charged particles can potentially reach sub-millimeter spatial resolution and 100 ps time resolution. This contribution introduces a Fast Timing MPGD technology optimized to detect photons, as an innovative PET imaging detector concept and emphases the importance of full detector simulation to guide the design of the detector geometry. The design and development of a new FTM, combining excellent time and spatial resolution, while exploiting the advantages of a reasonable energy resolution, will be a boost for the design of affordable TOF-PET scanner with improved image contrast. The use of such an affordable gas detector allows to instrument large areas in a cost-effective way, and to increase in image contrast for shorter scanning times (lowering the risk for the patient) and better diagnosis of the disease. In this report a dedicated simulation study is performed to optimize the detector design in the contest of the INFN project MPGD-Fatima. Results are obtained with ANSYS, COMSOL, GARFIELD++ and GEANT4 simulation tools. The final detector layout will be trade-off between fast time and good energy resolution. Copyright © 2017.

High mass resolution time of flight mass spectrometer for measuring products in heterogeneous catalysis in highly sensitive microreactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Andersen, T.; Jensen, R.; Christensen, M. K.

2012-07-15

We demonstrate a combined microreactor and time of flight system for testing and characterization of heterogeneous catalysts with high resolution mass spectrometry and high sensitivity. Catalyst testing is performed in silicon-based microreactors which have high sensitivity and fast thermal response. Gas analysis is performed with a time of flight mass spectrometer with a modified nude Bayard-Alpert ionization gauge as gas ionization source. The mass resolution of the time of flight mass spectrometer using the ion gauge as ionization source is estimated to m/{Delta}m > 2500. The system design is superior to conventional batch and flow reactors with accompanying product detectionmore » by quadrupole mass spectrometry or gas chromatography not only due to the high sensitivity, fast temperature response, high mass resolution, and fast acquisition time of mass spectra but it also allows wide mass range (0-5000 amu in the current configuration). As a demonstration of the system performance we present data from ammonia oxidation on a Pt thin film showing resolved spectra of OH and NH{sub 3}.« less

High mass resolution time of flight mass spectrometer for measuring products in heterogeneous catalysis in highly sensitive microreactors

NASA Astrophysics Data System (ADS)

Andersen, T.; Jensen, R.; Christensen, M. K.; Pedersen, T.; Hansen, O.; Chorkendorff, I.

2012-07-01

We demonstrate a combined microreactor and time of flight system for testing and characterization of heterogeneous catalysts with high resolution mass spectrometry and high sensitivity. Catalyst testing is performed in silicon-based microreactors which have high sensitivity and fast thermal response. Gas analysis is performed with a time of flight mass spectrometer with a modified nude Bayard-Alpert ionization gauge as gas ionization source. The mass resolution of the time of flight mass spectrometer using the ion gauge as ionization source is estimated to m/Δm > 2500. The system design is superior to conventional batch and flow reactors with accompanying product detection by quadrupole mass spectrometry or gas chromatography not only due to the high sensitivity, fast temperature response, high mass resolution, and fast acquisition time of mass spectra but it also allows wide mass range (0-5000 amu in the current configuration). As a demonstration of the system performance we present data from ammonia oxidation on a Pt thin film showing resolved spectra of OH and NH3.

High mass resolution time of flight mass spectrometer for measuring products in heterogeneous catalysis in highly sensitive microreactors.

PubMed

Andersen, T; Jensen, R; Christensen, M K; Pedersen, T; Hansen, O; Chorkendorff, I

2012-07-01

We demonstrate a combined microreactor and time of flight system for testing and characterization of heterogeneous catalysts with high resolution mass spectrometry and high sensitivity. Catalyst testing is performed in silicon-based microreactors which have high sensitivity and fast thermal response. Gas analysis is performed with a time of flight mass spectrometer with a modified nude Bayard-Alpert ionization gauge as gas ionization source. The mass resolution of the time of flight mass spectrometer using the ion gauge as ionization source is estimated to m/Δm > 2500. The system design is superior to conventional batch and flow reactors with accompanying product detection by quadrupole mass spectrometry or gas chromatography not only due to the high sensitivity, fast temperature response, high mass resolution, and fast acquisition time of mass spectra but it also allows wide mass range (0-5000 amu in the current configuration). As a demonstration of the system performance we present data from ammonia oxidation on a Pt thin film showing resolved spectra of OH and NH(3).

Photonics-based real-time ultra-high-range-resolution radar with broadband signal generation and processing.

PubMed

Zhang, Fangzheng; Guo, Qingshui; Pan, Shilong

2017-10-23

Real-time and high-resolution target detection is highly desirable in modern radar applications. Electronic techniques have encountered grave difficulties in the development of such radars, which strictly rely on a large instantaneous bandwidth. In this article, a photonics-based real-time high-range-resolution radar is proposed with optical generation and processing of broadband linear frequency modulation (LFM) signals. A broadband LFM signal is generated in the transmitter by photonic frequency quadrupling, and the received echo is de-chirped to a low frequency signal by photonic frequency mixing. The system can operate at a high frequency and a large bandwidth while enabling real-time processing by low-speed analog-to-digital conversion and digital signal processing. A conceptual radar is established. Real-time processing of an 8-GHz LFM signal is achieved with a sampling rate of 500 MSa/s. Accurate distance measurement is implemented with a maximum error of 4 mm within a range of ~3.5 meters. Detection of two targets is demonstrated with a range-resolution as high as 1.875 cm. We believe the proposed radar architecture is a reliable solution to overcome the limitations of current radar on operation bandwidth and processing speed, and it is hopefully to be used in future radars for real-time and high-resolution target detection and imaging.

Single-shot and single-sensor high/super-resolution microwave imaging based on metasurface

PubMed Central

Wang, Libo; Li, Lianlin; Li, Yunbo; Zhang, Hao Chi; Cui, Tie Jun

2016-01-01

Real-time high-resolution (including super-resolution) imaging with low-cost hardware is a long sought-after goal in various imaging applications. Here, we propose broadband single-shot and single-sensor high-/super-resolution imaging by using a spatio-temporal dispersive metasurface and an imaging reconstruction algorithm. The metasurface with spatio-temporal dispersive property ensures the feasibility of the single-shot and single-sensor imager for super- and high-resolution imaging, since it can convert efficiently the detailed spatial information of the probed object into one-dimensional time- or frequency-dependent signal acquired by a single sensor fixed in the far-field region. The imaging quality can be improved by applying a feature-enhanced reconstruction algorithm in post-processing, and the desired imaging resolution is related to the distance between the object and metasurface. When the object is placed in the vicinity of the metasurface, the super-resolution imaging can be realized. The proposed imaging methodology provides a unique means to perform real-time data acquisition, high-/super-resolution images without employing expensive hardware (e.g. mechanical scanner, antenna array, etc.). We expect that this methodology could make potential breakthroughs in the areas of microwave, terahertz, optical, and even ultrasound imaging. PMID:27246668

Design and performance of a high spatial resolution, time-of-flight PET detector

PubMed Central

Krishnamoorthy, Srilalan; LeGeyt, Benjamin; Werner, Matthew E.; Kaul, Madhuri; Newcomer, F. M.; Karp, Joel S.; Surti, Suleman

2014-01-01

This paper describes the design and performance of a high spatial resolution PET detector with time-of-flight capabilities. With an emphasis on high spatial resolution and sensitivity, we initially evaluated the performance of several 1.5 × 1.5 and 2.0 × 2.0 mm2 and 12–15 mm long LYSO crystals read out by several appropriately sized PMTs. Experiments to evaluate the impact of reflector on detector performance were performed and the final detector consisted of a 32 × 32 array of 1.5 × 1.5 × 15 mm3 LYSO crystals packed with a diffuse reflector and read out by a single Hamamatsu 64 channel multi-anode PMT. Such a design made it compact, modular and offered a cost-effective solution to obtaining excellent energy and timing resolution. To minimize the number of readout signals, a compact front-end readout electronics that summed anode signals along each of the orthogonal directions was also developed. Experimental evaluation of detector performance demonstrates clear discrimination of the crystals within the detector. An average energy resolution (FWHM) of 12.7 ± 2.6% and average coincidence timing resolution (FWHM) of 348 ps was measured, demonstrating suitability for use in the development of a high spatial resolution time-of-flight scanner for dedicated breast PET imaging. PMID:25246711

Estimation of time resolution for DOI-PET detector using diameter 0.2 mm WLS fibers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kobayashi, A.; Ito, H.; Han, S.

We are developing the whole-body PET detector with high position resolution (1 mm) and low cost (1 M dollars). Scintillator plates, Wave Length Sifting Fibers and SiPMs are used. In this work, time resolution of our PET detector is estimated. Our detector may also have good time resolution such as a few ps. (authors)

ON THE IMPACT OF SUPER RESOLUTION WSR-88D DOPPLER RADAR DATA ASSIMILATION ON HIGH RESOLUTION NUMERICAL MODEL FORECASTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chiswell, S

2009-01-11

Assimilation of radar velocity and precipitation fields into high-resolution model simulations can improve precipitation forecasts with decreased 'spin-up' time and improve short-term simulation of boundary layer winds (Benjamin, 2004 & 2007; Xiao, 2008) which is critical to improving plume transport forecasts. Accurate description of wind and turbulence fields is essential to useful atmospheric transport and dispersion results, and any improvement in the accuracy of these fields will make consequence assessment more valuable during both routine operation as well as potential emergency situations. During 2008, the United States National Weather Service (NWS) radars implemented a significant upgrade which increased the real-timemore » level II data resolution to 8 times their previous 'legacy' resolution, from 1 km range gate and 1.0 degree azimuthal resolution to 'super resolution' 250 m range gate and 0.5 degree azimuthal resolution (Fig 1). These radar observations provide reflectivity, velocity and returned power spectra measurements at a range of up to 300 km (460 km for reflectivity) at a frequency of 4-5 minutes and yield up to 13.5 million point observations per level in super-resolution mode. The migration of National Weather Service (NWS) WSR-88D radars to super resolution is expected to improve warning lead times by detecting small scale features sooner with increased reliability; however, current operational mesoscale model domains utilize grid spacing several times larger than the legacy data resolution, and therefore the added resolution of radar data is not fully exploited. The assimilation of super resolution reflectivity and velocity data into high resolution numerical weather model forecasts where grid spacing is comparable to the radar data resolution is investigated here to determine the impact of the improved data resolution on model predictions.« less

Spatially detailed retrievals of spring phenology from single-season high-resolution image time series

NASA Astrophysics Data System (ADS)

Vrieling, Anton; Skidmore, Andrew K.; Wang, Tiejun; Meroni, Michele; Ens, Bruno J.; Oosterbeek, Kees; O'Connor, Brian; Darvishzadeh, Roshanak; Heurich, Marco; Shepherd, Anita; Paganini, Marc

2017-07-01

Vegetation indices derived from satellite image time series have been extensively used to estimate the timing of phenological events like season onset. Medium spatial resolution (≥250 m) satellite sensors with daily revisit capability are typically employed for this purpose. In recent years, phenology is being retrieved at higher resolution (≤30 m) in response to increasing availability of high-resolution satellite data. To overcome the reduced acquisition frequency of such data, previous attempts involved fusion between high- and medium-resolution data, or combinations of multi-year acquisitions in a single phenological reconstruction. The objectives of this study are to demonstrate that phenological parameters can now be retrieved from single-season high-resolution time series, and to compare these retrievals against those derived from multi-year high-resolution and single-season medium-resolution satellite data. The study focuses on the island of Schiermonnikoog, the Netherlands, which comprises a highly-dynamic saltmarsh, dune vegetation, and agricultural land. Combining NDVI series derived from atmospherically-corrected images from RapidEye (5 m-resolution) and the SPOT5 Take5 experiment (10m-resolution) acquired between March and August 2015, phenological parameters were estimated using a function fitting approach. We then compared results with phenology retrieved from four years of 30 m Landsat 8 OLI data, and single-year 100 m Proba-V and 250 m MODIS temporal composites of the same period. Retrieved phenological parameters from combined RapidEye/SPOT5 displayed spatially consistent results and a large spatial variability, providing complementary information to existing vegetation community maps. Retrievals that combined four years of Landsat observations into a single synthetic year were affected by the inclusion of years with warmer spring temperatures, whereas adjustment of the average phenology to 2015 observations was only feasible for a few pixels due to cloud cover around phenological transition dates. The Proba-V and MODIS phenology retrievals scaled poorly relative to their high-resolution equivalents, indicating that medium-resolution phenology retrievals need to be interpreted with care, particularly in landscapes with fine-scale land cover variability.

All-passive pixel super-resolution of time-stretch imaging

PubMed Central

Chan, Antony C. S.; Ng, Ho-Cheung; Bogaraju, Sharat C. V.; So, Hayden K. H.; Lam, Edmund Y.; Tsia, Kevin K.

2017-01-01

Based on image encoding in a serial-temporal format, optical time-stretch imaging entails a stringent requirement of state-of-the-art fast data acquisition unit in order to preserve high image resolution at an ultrahigh frame rate — hampering the widespread utilities of such technology. Here, we propose a pixel super-resolution (pixel-SR) technique tailored for time-stretch imaging that preserves pixel resolution at a relaxed sampling rate. It harnesses the subpixel shifts between image frames inherently introduced by asynchronous digital sampling of the continuous time-stretch imaging process. Precise pixel registration is thus accomplished without any active opto-mechanical subpixel-shift control or other additional hardware. Here, we present the experimental pixel-SR image reconstruction pipeline that restores high-resolution time-stretch images of microparticles and biological cells (phytoplankton) at a relaxed sampling rate (≈2–5 GSa/s)—more than four times lower than the originally required readout rate (20 GSa/s) — is thus effective for high-throughput label-free, morphology-based cellular classification down to single-cell precision. Upon integration with the high-throughput image processing technology, this pixel-SR time-stretch imaging technique represents a cost-effective and practical solution for large scale cell-based phenotypic screening in biomedical diagnosis and machine vision for quality control in manufacturing. PMID:28303936

Automatic optimization high-speed high-resolution OCT retinal imaging at 1μm

NASA Astrophysics Data System (ADS)

Cua, Michelle; Liu, Xiyun; Miao, Dongkai; Lee, Sujin; Lee, Sieun; Bonora, Stefano; Zawadzki, Robert J.; Mackenzie, Paul J.; Jian, Yifan; Sarunic, Marinko V.

2015-03-01

High-resolution OCT retinal imaging is important in providing visualization of various retinal structures to aid researchers in better understanding the pathogenesis of vision-robbing diseases. However, conventional optical coherence tomography (OCT) systems have a trade-off between lateral resolution and depth-of-focus. In this report, we present the development of a focus-stacking optical coherence tomography (OCT) system with automatic optimization for high-resolution, extended-focal-range clinical retinal imaging. A variable-focus liquid lens was added to correct for de-focus in real-time. A GPU-accelerated segmentation and optimization was used to provide real-time layer-specific enface visualization as well as depth-specific focus adjustment. After optimization, multiple volumes focused at different depths were acquired, registered, and stitched together to yield a single, high-resolution focus-stacked dataset. Using this system, we show high-resolution images of the ONH, from which we extracted clinically-relevant parameters such as the nerve fiber layer thickness and lamina cribrosa microarchitecture.

High speed, real-time, camera bandwidth converter

DOEpatents

Bower, Dan E; Bloom, David A; Curry, James R

2014-10-21

Image data from a CMOS sensor with 10 bit resolution is reformatted in real time to allow the data to stream through communications equipment that is designed to transport data with 8 bit resolution. The incoming image data has 10 bit resolution. The communication equipment can transport image data with 8 bit resolution. Image data with 10 bit resolution is transmitted in real-time, without a frame delay, through the communication equipment by reformatting the image data.

Ultra high resolution molecular beam cars spectroscopy with application to planetary atmospheric molecules

NASA Technical Reports Server (NTRS)

Byer, R. L.

1982-01-01

The measurement of high resolution pulsed and continuous wave (CW) coherent anti-Stokes Raman spectroscopy (CARS) measurements in pulsed and steady state supersonic expansions were demonstrated. Pulsed molecular beam sources were characterized, and saturation of a Raman transition and, for the first time, the Raman spectrum of a complex molecular cluster were observed. The observation of CW CARS spectra in a molecular expansion and the effects of transit time broadening is described. Supersonic expansion is established as a viable technique for high resolution Raman spectroscopy of cold molecules with resolutions of 100 MH2.

Early development in synthetic aperture lidar sensing and processing for on-demand high resolution imaging

NASA Astrophysics Data System (ADS)

Bergeron, Alain; Turbide, Simon; Terroux, Marc; Marchese, Linda; Harnisch, Bernd

2017-11-01

The quest for real-time high resolution is of prime importance for surveillance applications specially in disaster management and rescue mission. Synthetic aperture radar provides meter-range resolution images in all weather conditions. Often installed on satellites the revisit time can be too long to support real-time operations on the ground. Synthetic aperture lidar can be lightweight and offers centimeter-range resolution. Onboard airplane or unmanned air vehicle this technology would allow for timelier reconnaissance. INO has developed a synthetic aperture radar table prototype and further used a real-time optronic processor to fulfill image generation on-demand. The early positive results using both technologies are presented in this paper.

Near-real-time mosaics from high-resolution side-scan sonar

USGS Publications Warehouse

Danforth, William W.; O'Brien, Thomas F.; Schwab, W.C.

1991-01-01

High-resolution side-scan sonar has proven to be a very effective tool for stuyding and understanding the surficial geology of the seafloor. Since the mid-1970s, the US Geological Survey has used high-resolution side-scan sonar systems for mapping various areas of the continental shelf. However, two problems typically encountered included the short range and the high sampling rate of high-resolution side-scan sonar systems and the acquisition and real-time processing of the enormous volume of sonar data generated by high-resolution suystems. These problems were addressed and overcome in August 1989 when the USGS conducted a side-scan sonar and bottom sampling survey of a 1000-sq-km section of the continental shelf in the Gulf of Farallones located offshore of San Francisco. The primary goal of this survey was to map an area of critical interest for studying continental shelf sediment dynamics. This survey provided an opportunity to test an image processing scheme that enabled production of a side-scan sonar hard-copy mosaic during the cruise in near real-time.

A high-resolution time-to-digital converter using a three-level resolution

NASA Astrophysics Data System (ADS)

Dehghani, Asma; Saneei, Mohsen; Mahani, Ali

2016-08-01

In this article, a three-level resolution Vernier delay line time-to-digital converter (TDC) was proposed. The proposed TDC core was based on the pseudo-differential digital architecture that made it insensitive to nMOS and pMOS transistor mismatches. It also employed a Vernier delay line (VDL) in conjunction with an asynchronous read-out circuitry. The time interval resolution was equal to the difference of delay between buffers of upper and lower chains. Then, via the extra chain included in the lower delay line, resolution was controlled and power consumption was reduced. This method led to high resolution and low power consumption. The measurement results of TDC showed a resolution of 4.5 ps, 12-bit output dynamic range, and integral nonlinearity of 1.5 least significant bits. This TDC achieved the consumption of 68.43 µW from 1.1-V supply.

A high resolution soil moisture radiometer

NASA Technical Reports Server (NTRS)

Dod, L. R.

1980-01-01

The design of an L-band high resolution soil moisture radiometer is described. The selected system is a planar slotted waveguide array at L-band frequencies. The square aperture is 74.75 m by 74.75 m subdivided into 8 tilted subarrays. The system has a 290 km circular orbit and provides a spatial resolution of 1 km. The aperture forms 230 simultaneous beams in a cross-track pattern which covers a swath 420 km wide. A revisit time of 6 days is provided for an orbit inclination of 50 deg. The 1 km resolution cell allows an integration time of 1/7 second and sharing this time period sequentially between two orthogonal polarization modes can provide a temperature resolution of 0.7 K.

Comparison of High-Resolution MR Imaging and Digital Subtraction Angiography for the Characterization and Diagnosis of Intracranial Artery Disease.

PubMed

Lee, N J; Chung, M S; Jung, S C; Kim, H S; Choi, C-G; Kim, S J; Lee, D H; Suh, D C; Kwon, S U; Kang, D-W; Kim, J S

2016-12-01

High-resolution MR imaging has recently been introduced as a promising diagnostic modality in intracranial artery disease. Our aim was to compare high-resolution MR imaging with digital subtraction angiography for the characterization and diagnosis of various intracranial artery diseases. Thirty-seven patients who had undergone both high-resolution MR imaging and DSA for intracranial artery disease were enrolled in our study (August 2011 to April 2014). The time interval between the high-resolution MR imaging and DSA was within 1 month. The degree of stenosis and the minimal luminal diameter were independently measured by 2 observers in both DSA and high-resolution MR imaging, and the results were compared. Two observers independently diagnosed intracranial artery diseases on DSA and high-resolution MR imaging. The time interval between the diagnoses on DSA and high-resolution MR imaging was 2 weeks. Interobserver diagnostic agreement for each technique and intermodality diagnostic agreement for each observer were acquired. High-resolution MR imaging showed moderate-to-excellent agreement (interclass correlation coefficient = 0.892-0.949; κ = 0.548-0.614) and significant correlations (R = 0.766-892) with DSA on the degree of stenosis and minimal luminal diameter. The interobserver diagnostic agreement was good for DSA (κ = 0.643) and excellent for high-resolution MR imaging (κ = 0.818). The intermodality diagnostic agreement was good (κ = 0.704) for observer 1 and moderate (κ = 0.579) for observer 2, respectively. High-resolution MR imaging may be an imaging method comparable with DSA for the characterization and diagnosis of various intracranial artery diseases. © 2016 by American Journal of Neuroradiology.

High Resolution Mesoscale Weather Data Improvement to Spatial Effects for Dose-Rate Contour Plot Predictions

DTIC Science & Technology

2007-03-01

time. This is a very powerful tool in determining fine spatial resolution , as boundary conditions are not only updated at every timestep, but the ...HIGH RESOLUTION MESOSCALE WEATHER DATA IMPROVEMENT TO SPATIAL EFFECTS FOR DOSE-RATE CONTOUR PLOT PREDICTIONS THESIS Christopher P...11 1 HIGH RESOLUTION MESOSCALE WEATHER DATA IMPROVEMENT TO SPATIAL EFFECTS FOR DOSE-RATE CONTOUR PLOT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Donald F.; Schulz, Carl; Konijnenburg, Marco

High-resolution Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry imaging enables the spatial mapping and identification of biomolecules from complex surfaces. The need for long time-domain transients, and thus large raw file sizes, results in a large amount of raw data (“big data”) that must be processed efficiently and rapidly. This can be compounded by largearea imaging and/or high spatial resolution imaging. For FT-ICR, data processing and data reduction must not compromise the high mass resolution afforded by the mass spectrometer. The continuous mode “Mosaic Datacube” approach allows high mass resolution visualization (0.001 Da) of mass spectrometry imaging data, butmore » requires additional processing as compared to featurebased processing. We describe the use of distributed computing for processing of FT-ICR MS imaging datasets with generation of continuous mode Mosaic Datacubes for high mass resolution visualization. An eight-fold improvement in processing time is demonstrated using a Dutch nationally available cloud service.« less

High resolution data acquisition

DOEpatents

Thornton, G.W.; Fuller, K.R.

1993-04-06

A high resolution event interval timing system measures short time intervals such as occur in high energy physics or laser ranging. Timing is provided from a clock, pulse train, and analog circuitry for generating a triangular wave synchronously with the pulse train (as seen in diagram on patent). The triangular wave has an amplitude and slope functionally related to the time elapsed during each clock pulse in the train. A converter forms a first digital value of the amplitude and slope of the triangle wave at the start of the event interval and a second digital value of the amplitude and slope of the triangle wave at the end of the event interval. A counter counts the clock pulse train during the interval to form a gross event interval time. A computer then combines the gross event interval time and the first and second digital values to output a high resolution value for the event interval.

High resolution data acquisition

DOEpatents

Thornton, Glenn W.; Fuller, Kenneth R.

1993-01-01

A high resolution event interval timing system measures short time intervals such as occur in high energy physics or laser ranging. Timing is provided from a clock (38) pulse train (37) and analog circuitry (44) for generating a triangular wave (46) synchronously with the pulse train (37). The triangular wave (46) has an amplitude and slope functionally related to the time elapsed during each clock pulse in the train. A converter (18, 32) forms a first digital value of the amplitude and slope of the triangle wave at the start of the event interval and a second digital value of the amplitude and slope of the triangle wave at the end of the event interval. A counter (26) counts the clock pulse train (37) during the interval to form a gross event interval time. A computer (52) then combines the gross event interval time and the first and second digital values to output a high resolution value for the event interval.

Image processing enhancement of high-resolution TEM micrographs of nanometer-size metal particles

NASA Technical Reports Server (NTRS)

Artal, P.; Avalos-Borja, M.; Soria, F.; Poppa, H.; Heinemann, K.

1989-01-01

The high-resolution TEM detectability of lattice fringes from metal particles supported on substrates is impeded by the substrate itself. Single value decomposition (SVD) and Fourier filtering (FFT) methods were applied to standard high resolution micrographs to enhance lattice resolution from particles as well as from crystalline substrates. SVD produced good results for one direction of fringes, and it can be implemented as a real-time process. Fourier methods are independent of azimuthal directions and allow separation of particle lattice planes from those pertaining to the substrate, which makes it feasible to detect possible substrate distortions produced by the supported particle. This method, on the other hand, is more elaborate, requires more computer time than SVD and is, therefore, less likely to be used in real-time image processing applications.

High-sensitivity Leak-testing Method with High-Resolution Integration Technique

NASA Astrophysics Data System (ADS)

Fujiyoshi, Motohiro; Nonomura, Yutaka; Senda, Hidemi

A high-resolution leak-testing method named HR (High-Resolution) Integration Technique has been developed for MEMS (Micro Electro Mechanical Systems) sensors such as a vibrating angular-rate sensor housed in a vacuum package. Procedures of the method to obtain high leak-rate resolution were as follows. A package filled with helium gas was kept in a small accumulation chamber to accumulate helium gas leaking from the package. After the accumulation, the accumulated helium gas was introduced into a mass spectrometer in a short period of time, and the flux of the helium gas was measured by the mass spectrometer as a transient phenomenon. The leak-rate of the package was calculated from the detected transient waveform of the mass spectrometer and the accumulation time of the helium gas in the accumulation chamber. Because the density of the helium gas in the vacuum chamber increased and the accumulated helium gas was measured in a very short period of time with the mass spectrometer, the peak strength of the transient waveform became high and the signal to noise ratio was much improved. The detectable leak-rate resolution of the technique reached 1×10-15 (Pa·m3/s). This resolution is 103 times superior to that of the conventional helium vacuum integration method. The accuracy of the measuring system was verified with a standard helium gas leak source. The results were well matched between theoretical calculation based on the leak-rate of the source and the experimental results within only 2% error.

Employing temporal self-similarity across the entire time domain in computed tomography reconstruction

PubMed Central

Kazantsev, D.; Van Eyndhoven, G.; Lionheart, W. R. B.; Withers, P. J.; Dobson, K. J.; McDonald, S. A.; Atwood, R.; Lee, P. D.

2015-01-01

There are many cases where one needs to limit the X-ray dose, or the number of projections, or both, for high frame rate (fast) imaging. Normally, it improves temporal resolution but reduces the spatial resolution of the reconstructed data. Fortunately, the redundancy of information in the temporal domain can be employed to improve spatial resolution. In this paper, we propose a novel regularizer for iterative reconstruction of time-lapse computed tomography. The non-local penalty term is driven by the available prior information and employs all available temporal data to improve the spatial resolution of each individual time frame. A high-resolution prior image from the same or a different imaging modality is used to enhance edges which remain stationary throughout the acquisition time while dynamic features tend to be regularized spatially. Effective computational performance together with robust improvement in spatial and temporal resolution makes the proposed method a competitive tool to state-of-the-art techniques. PMID:25939621

High time-resolution photodetectors for PET applications

DOE PAGES

Ronzhin, Anatoly

2016-02-01

This paper describes recent developments aiming at the improvement of the time resolution of photodetectors used in positron emission tomography (PET). Promising photodetector candidates for future PET-time-of-flight (TOF) applications are also discussed.

Data Descriptor: TerraClimate, a high-resolution global dataset of monthly climate and climatic water balance from 1958-2015

Treesearch

John T. Abatzoglou; Solomon Z. Dobrowski; Sean A. Parks; Katherine C. Hegewisch

2018-01-01

We present TerraClimate, a dataset of high-spatial resolution (1/24°, ~4-km) monthly climate and climatic water balance for global terrestrial surfaces from 1958–2015. TerraClimate uses climatically aided interpolation, combining high-spatial resolution climatological normals from the WorldClim dataset, with coarser resolution time varying (i.e., monthly) data from...

Assessment of a vertical high-resolution distributed-temperature-sensing system in a shallow thermohaline environment

NASA Astrophysics Data System (ADS)

Suárez, F.; Aravena, J. E.; Hausner, M. B.; Childress, A. E.; Tyler, S. W.

2011-03-01

In shallow thermohaline-driven lakes it is important to measure temperature on fine spatial and temporal scales to detect stratification or different hydrodynamic regimes. Raman spectra distributed temperature sensing (DTS) is an approach available to provide high spatial and temporal temperature resolution. A vertical high-resolution DTS system was constructed to overcome the problems of typical methods used in the past, i.e., without disturbing the water column, and with resistance to corrosive environments. This paper describes a method to quantitatively assess accuracy, precision and other limitations of DTS systems to fully utilize the capacity of this technology, with a focus on vertical high-resolution to measure temperatures in shallow thermohaline environments. It also presents a new method to manually calibrate temperatures along the optical fiber achieving significant improved resolution. The vertical high-resolution DTS system is used to monitor the thermal behavior of a salt-gradient solar pond, which is an engineered shallow thermohaline system that allows collection and storage of solar energy for a long period of time. The vertical high-resolution DTS system monitors the temperature profile each 1.1 cm vertically and in time averages as small as 10 s. Temperature resolution as low as 0.035 °C is obtained when the data are collected at 5-min intervals.

Xenia Mission: Spacecraft Design Concept

NASA Technical Reports Server (NTRS)

Hopkins, R. C.; Johnson, C. L.; Kouveliotou, C.; Jones, D.; Baysinger, M.; Bedsole, T.; Maples, C. C.; Benfield, P. J.; Turner, M.; Capizzo, P.;

A 4.2 ps Time-Interval RMS Resolution Time-to-Digital Converter Using a Bin Decimation Method in an UltraScale FPGA

NASA Astrophysics Data System (ADS)

Wang, Yonggang; Liu, Chong

2016-10-01

The common solution for a field programmable gate array (FPGA)-based time-to-digital converter (TDC) is constructing a tapped delay line (TDL) for time interpolation to yield a sub-clock time resolution. The granularity and uniformity of the delay elements of TDL determine the TDC time resolution. In this paper, we propose a dual-sampling TDL architecture and a bin decimation method that could make the delay elements as small and uniform as possible, so that the implemented TDCs can achieve a high time resolution beyond the intrinsic cell delay. Two identical full hardware-based TDCs were implemented in a Xilinx UltraScale FPGA for performance evaluation. For fixed time intervals in the range from 0 to 440 ns, the average time-interval RMS resolution is measured by the two TDCs with 4.2 ps, thus the timestamp resolution of single TDC is derived as 2.97 ps. The maximum hit rate of the TDC is as high as half the system clock rate of FPGA, namely 250 MHz in our demo prototype. Because the conventional online bin-by-bin calibration is not needed, the implementation of the proposed TDC is straightforward and relatively resource-saving.

Improved Resolution Optical Time Stretch Imaging Based on High Efficiency In-Fiber Diffraction.

PubMed

Wang, Guoqing; Yan, Zhijun; Yang, Lei; Zhang, Lin; Wang, Chao

2018-01-12

Most overlooked challenges in ultrafast optical time stretch imaging (OTSI) are sacrificed spatial resolution and higher optical loss. These challenges are originated from optical diffraction devices used in OTSI, which encode image into spectra of ultrashort optical pulses. Conventional free-space diffraction gratings, as widely used in existing OTSI systems, suffer from several inherent drawbacks: limited diffraction efficiency in a non-Littrow configuration due to inherent zeroth-order reflection, high coupling loss between free-space gratings and optical fibers, bulky footprint, and more importantly, sacrificed imaging resolution due to non-full-aperture illumination for individual wavelengths. Here we report resolution-improved and diffraction-efficient OTSI using in-fiber diffraction for the first time to our knowledge. The key to overcome the existing challenges is a 45° tilted fiber grating (TFG), which serves as a compact in-fiber diffraction device offering improved diffraction efficiency (up to 97%), inherent compatibility with optical fibers, and improved imaging resolution owning to almost full-aperture illumination for all illumination wavelengths. 50 million frames per second imaging of fast moving object at 46 m/s with improved imaging resolution has been demonstrated. This conceptually new in-fiber diffraction design opens the way towards cost-effective, compact and high-resolution OTSI systems for image-based high-throughput detection and measurement.

Radio frequency phototube and optical clock: High resolution, high rate and highly stable single photon timing technique

DOE Office of Scientific and Technical Information (OSTI.GOV)

Margaryan, Amur

2011-10-01

A new timing technique for single photons based on the radio frequency phototube and optical clock or femtosecond optical frequency comb generator is proposed. The technique has a 20 ps resolution for single photons, is capable of operating with MHz frequencies and achieving 10 fs instability level.

High-resolution radiography by means of a hodoscope

DOEpatents

De Volpi, Alexander

1978-01-01

The fast neutron hodoscope, a device that produces neutron radiographs with coarse space resolution in a short time, is modified to produce neutron or gamma radiographs of relatively thick samples and with high space resolution. The modification comprises motorizing a neutron and gamma collimator to permit a controlled scanning pattern, simultaneous collection of data in a number of hodoscope channels over a period of time, and computerized image reconstruction of the data thus gathered.

High-resolution near real-time drought monitoring in South Asia

NASA Astrophysics Data System (ADS)

Aadhar, Saran; Mishra, Vimal

2017-10-01

Drought in South Asia affect food and water security and pose challenges for millions of people. For policy-making, planning, and management of water resources at sub-basin or administrative levels, high-resolution datasets of precipitation and air temperature are required in near-real time. We develop a high-resolution (0.05°) bias-corrected precipitation and temperature data that can be used to monitor near real-time drought conditions over South Asia. Moreover, the dataset can be used to monitor climatic extremes (heat and cold waves, dry and wet anomalies) in South Asia. A distribution mapping method was applied to correct bias in precipitation and air temperature, which performed well compared to the other bias correction method based on linear scaling. Bias-corrected precipitation and temperature data were used to estimate Standardized precipitation index (SPI) and Standardized Precipitation Evapotranspiration Index (SPEI) to assess the historical and current drought conditions in South Asia. We evaluated drought severity and extent against the satellite-based Normalized Difference Vegetation Index (NDVI) anomalies and satellite-driven Drought Severity Index (DSI) at 0.05°. The bias-corrected high-resolution data can effectively capture observed drought conditions as shown by the satellite-based drought estimates. High resolution near real-time dataset can provide valuable information for decision-making at district and sub-basin levels.

Performance characterization of high quantum efficiency metal package photomultiplier tubes for time-of-flight and high-resolution PET applications.

PubMed

Ko, Guen Bae; Lee, Jae Sung

2015-01-01

Metal package photomultiplier tubes (PMTs) with a metal channel dynode structure have several advanced features for devising such time-of-flight (TOF) and high spatial resolution positron emission tomography (PET) detectors, thanks to their high packing density, large effective area ratio, fast time response, and position encoding capability. Here, we report on an investigation of new metal package PMTs with high quantum efficiency (QE) for high-resolution PET and TOF PET detector modules. The latest metal package PMT, the Hamamatsu R11265 series, is served with two kinds of photocathodes that have higher quantum efficiency than normal bialkali (typical QE ≈ 25%), super bialkali (SBA; QE ≈ 35%), and ultra bialkali (UBA; QE ≈ 43%). In this study, the authors evaluated the performance of the new PMTs with SBA and UBA photocathodes as a PET detector by coupling various crystal arrays. They also investigated the performance improvements of high QE, focusing in particular on a block detector coupled with a lutetium-based scintillator. A single 4 × 4 × 10 mm(3) LYSO, a 7 × 7 array of 3 × 3 × 20 mm(3) LGSO, a 9 × 9 array of 1.2 × 1.2 × 10 mm(3) LYSO, and a 6 × 6 array of 1.5 × 1.5 × 7 mm(3) LuYAP were used for evaluation. All coincidence data were acquired with a DRS4 based fast digitizer. This new PMT shows promising crystal positioning accuracy, energy and time discrimination performance for TOF, and high-resolution PET applications. The authors also found that a metal channel PMT with SBA was enough for both TOF and high-resolution application, although UBA gave a minor improvement to time resolution. However, significant performance improvement was observed in relative low light output crystals (LuYAP) coupled with UBA. The results of this study will be of value as a useful reference to select PMTs for high-performance PET detectors.

A high-throughput, multi-channel photon-counting detector with picosecond timing

NASA Astrophysics Data System (ADS)

Lapington, J. S.; Fraser, G. W.; Miller, G. M.; Ashton, T. J. R.; Jarron, P.; Despeisse, M.; Powolny, F.; Howorth, J.; Milnes, J.

2009-06-01

High-throughput photon counting with high time resolution is a niche application area where vacuum tubes can still outperform solid-state devices. Applications in the life sciences utilizing time-resolved spectroscopies, particularly in the growing field of proteomics, will benefit greatly from performance enhancements in event timing and detector throughput. The HiContent project is a collaboration between the University of Leicester Space Research Centre, the Microelectronics Group at CERN, Photek Ltd., and end-users at the Gray Cancer Institute and the University of Manchester. The goal is to develop a detector system specifically designed for optical proteomics, capable of high content (multi-parametric) analysis at high throughput. The HiContent detector system is being developed to exploit this niche market. It combines multi-channel, high time resolution photon counting in a single miniaturized detector system with integrated electronics. The combination of enabling technologies; small pore microchannel plate devices with very high time resolution, and high-speed multi-channel ASIC electronics developed for the LHC at CERN, provides the necessary building blocks for a high-throughput detector system with up to 1024 parallel counting channels and 20 ps time resolution. We describe the detector and electronic design, discuss the current status of the HiContent project and present the results from a 64-channel prototype system. In the absence of an operational detector, we present measurements of the electronics performance using a pulse generator to simulate detector events. Event timing results from the NINO high-speed front-end ASIC captured using a fast digital oscilloscope are compared with data taken with the proposed electronic configuration which uses the multi-channel HPTDC timing ASIC.

Evaluation of Multi-Channel ADCs for Gamma-Ray Spectroscopy

NASA Astrophysics Data System (ADS)

Tan, Hui; Hennig, Wolfgang; Walby, Mark D.; Breus, Dimitry; Harris, Jackson

2013-04-01

As nuclear physicists increasingly design large scale experiments with hundreds or thousands of detector channels, there are growing needs for high density readout electronics with good timing and energy resolution that at the same time offer lower cost per channel compared to existing commercial solutions. Recent improvements in the design of commercial analog to digital converters (ADCs) have resulted in a variety of multi-channel ADCs that are natural choice for designing such high density readout modules. However, multi-channel ADCs typically are designed for medical imaging/ultrasound applications and therefore are not rated for their spectroscopic characteristics. In this work, we evaluated the gamma-ray spectroscopic performance of several multi-channel ADCs, including their energy resolution, nonlinearity, and timing resolution. Some of these ADCs demonstrated excellent energy resolution, 2.66% FWHM at 662 keV with a LaBr3 or 1.78 keV FWHM at 1332.5 keV with a high purity germanium (HPGe) detector, and sub-nanosecond timing resolution with LaBr 3. We present results from these measurements to illustrate their suitability for gamma-ray spectroscopy.

: Signal Decomposition of High Resolution Time Series River data to Separate Local and Regional Components of Conductivity

EPA Science Inventory

Signal processing techniques were applied to high-resolution time series data obtained from conductivity loggers placed upstream and downstream of a wastewater treatment facility along a river. Data was collected over 14-60 days, and several seasons. The power spectral densit...

Super-resolution reconstruction of diffusion parameters from diffusion-weighted images with different slice orientations.

PubMed

Van Steenkiste, Gwendolyn; Jeurissen, Ben; Veraart, Jelle; den Dekker, Arnold J; Parizel, Paul M; Poot, Dirk H J; Sijbers, Jan

2016-01-01

Diffusion MRI is hampered by long acquisition times, low spatial resolution, and a low signal-to-noise ratio. Recently, methods have been proposed to improve the trade-off between spatial resolution, signal-to-noise ratio, and acquisition time of diffusion-weighted images via super-resolution reconstruction (SRR) techniques. However, during the reconstruction, these SRR methods neglect the q-space relation between the different diffusion-weighted images. An SRR method that includes a diffusion model and directly reconstructs high resolution diffusion parameters from a set of low resolution diffusion-weighted images was proposed. Our method allows an arbitrary combination of diffusion gradient directions and slice orientations for the low resolution diffusion-weighted images, optimally samples the q- and k-space, and performs motion correction with b-matrix rotation. Experiments with synthetic data and in vivo human brain data show an increase of spatial resolution of the diffusion parameters, while preserving a high signal-to-noise ratio and low scan time. Moreover, the proposed SRR method outperforms the previous methods in terms of the root-mean-square error. The proposed SRR method substantially increases the spatial resolution of MRI that can be obtained in a clinically feasible scan time. © 2015 Wiley Periodicals, Inc.

High-resolution short-exposure small-animal laboratory x-ray phase-contrast tomography

NASA Astrophysics Data System (ADS)

Larsson, Daniel H.; Vågberg, William; Yaroshenko, Andre; Yildirim, Ali Önder; Hertz, Hans M.

2016-12-01

X-ray computed tomography of small animals and their organs is an essential tool in basic and preclinical biomedical research. In both phase-contrast and absorption tomography high spatial resolution and short exposure times are of key importance. However, the observable spatial resolutions and achievable exposure times are presently limited by system parameters rather than more fundamental constraints like, e.g., dose. Here we demonstrate laboratory tomography with few-ten μm spatial resolution and few-minute exposure time at an acceptable dose for small-animal imaging, both with absorption contrast and phase contrast. The method relies on a magnifying imaging scheme in combination with a high-power small-spot liquid-metal-jet electron-impact source. The tomographic imaging is demonstrated on intact mouse, phantoms and excised lungs, both healthy and with pulmonary emphysema.

The influence of spatially and temporally high-resolution wind forcing on the power input to near-inertial waves in the ocean

NASA Astrophysics Data System (ADS)

Rimac, Antonija; von Storch, Jin-Song; Eden, Carsten

2013-04-01

The estimated power required to sustain global general circulation in the ocean is about 2 TW. This power is supplied with wind stress and tides. Energy spectrum shows pronounced maxima at near-inertial frequency. Near-inertial waves excited by high-frequency winds represent an important source for deep ocean mixing since they can propagate into the deep ocean and dissipate far away from the generation sites. The energy input by winds to near-inertial waves has been studied mostly using slab ocean models and wind stress forcing with coarse temporal resolution (e.g. 6-hourly). Slab ocean models lack the ability to reproduce fundamental aspects of kinetic energy balance and systematically overestimate the wind work. Also, slab ocean models do not account the energy used for the mixed layer deepening or the energy radiating downward into the deep ocean. Coarse temporal resolution of the wind forcing strongly underestimates the near-inertial energy. To overcome this difficulty we use an eddy permitting ocean model with high-frequency wind forcing. We establish the following model setup: We use the Max Planck Institute Ocean Model (MPIOM) on a tripolar grid with 45 km horizontal resolution and 40 vertical levels. We run the model with wind forcings that vary in horizontal and temporal resolution. We use high-resolution (1-hourly with 35 km horizontal resolution) and low-resolution winds (6-hourly with 250 km horizontal resolution). We address the following questions: Is the kinetic energy of near-inertial waves enhanced when high-resolution wind forcings are used? If so, is this due to higher level of overall wind variability or higher spatial or temporal resolution of wind forcing? How large is the power of near-inertial waves generated by winds? Our results show that near-inertial waves are enhanced and the near-inertial kinetic energy is two times higher (in the storm track regions 3.5 times higher) when high-resolution winds are used. Filtering high-resolution winds in space and time, the near-inertial kinetic energy reduces. The reduction is faster when a temporal filter is used suggesting that the high-frequency wind forcing is more efficient in generating near-inertial wave energy than the small-scale wind forcing. Using low-resolution wind forcing the wind generated power to near-inertial waves is 0.55 TW. When we use high-resolution wind forcing the result is 1.6 TW meaning that the result increases by 300%.

Rapid high-resolution spin- and angle-resolved photoemission spectroscopy with pulsed laser source and time-of-flight spectrometer

NASA Astrophysics Data System (ADS)

Gotlieb, K.; Hussain, Z.; Bostwick, A.; Lanzara, A.; Jozwiak, C.

2013-09-01

A high-efficiency spin- and angle-resolved photoemission spectroscopy (spin-ARPES) spectrometer is coupled with a laboratory-based laser for rapid high-resolution measurements. The spectrometer combines time-of-flight (TOF) energy measurements with low-energy exchange scattering spin polarimetry for high detection efficiencies. Samples are irradiated with fourth harmonic photons generated from a cavity-dumped Ti:sapphire laser that provides high photon flux in a narrow bandwidth, with a pulse timing structure ideally matched to the needs of the TOF spectrometer. The overall efficiency of the combined system results in near-EF spin-resolved ARPES measurements with an unprecedented combination of energy resolution and acquisition speed. This allows high-resolution spin measurements with a large number of data points spanning multiple dimensions of interest (energy, momentum, photon polarization, etc.) and thus enables experiments not otherwise possible. The system is demonstrated with spin-resolved energy and momentum mapping of the L-gap Au(111) surface states, a prototypical Rashba system. The successful integration of the spectrometer with the pulsed laser system demonstrates its potential for simultaneous spin- and time-resolved ARPES with pump-probe based measurements.

Time stamping of single optical photons with 10 ns resolution

NASA Astrophysics Data System (ADS)

Chakaberia, Irakli; Cotlet, Mircea; Fisher-Levine, Merlin; Hodges, Diedra R.; Nguyen, Jayke; Nomerotski, Andrei

2017-05-01

High spatial and temporal resolution are key features for many modern applications, e.g. mass spectrometry, probing the structure of materials via neutron scattering, studying molecular structure, etc.1-5 Fast imaging also provides the capability of coincidence detection, and the further addition of sensitivity to single optical photons with the capability of timestamping them further broadens the field of potential applications. Photon counting is already widely used in X-ray imaging,6 where the high energy of the photons makes their detection easier. TimepixCam is a novel optical imager,7 which achieves high spatial resolution using an array of 256×256 55 μm × 55μm pixels which have individually controlled functionality. It is based on a thin-entrance-window silicon sensor, bump-bonded to a Timepix ASIC.8 TimepixCam provides high quantum efficiency in the optical wavelength range (400-1000 nm). We perform the timestamping of single photons with a time resolution of 20 ns, by coupling TimepixCam to a fast image-intensifier with a P47 phosphor screen. The fast emission time of the P479 allows us to preserve good time resolution while maintaining the capability to focus the optical output of the intensifier onto the 256×256 pixel Timepix sensor area. We demonstrate the capability of the (TimepixCam + image intensifier) setup to provide high-resolution single-photon timestamping, with an effective frame rate of 50 MHz.

Analytical Calculation of the Lower Bound on Timing Resolution for PET Scintillation Detectors Comprising High-Aspect-Ratio Crystal Elements

PubMed Central

Cates, Joshua W.; Vinke, Ruud; Levin, Craig S.

2015-01-01

Excellent timing resolution is required to enhance the signal-to-noise ratio (SNR) gain available from the incorporation of time-of-flight (ToF) information in image reconstruction for positron emission tomography (PET). As the detector’s timing resolution improves, so does SNR, reconstructed image quality, and accuracy. This directly impacts the challenging detection and quantification tasks in the clinic. The recognition of these benefits has spurred efforts within the molecular imaging community to determine to what extent the timing resolution of scintillation detectors can be improved and develop near-term solutions for advancing ToF-PET. Presented in this work, is a method for calculating the Cramér-Rao lower bound (CRLB) on timing resolution for scintillation detectors with long crystal elements, where the influence of the variation in optical path length of scintillation light on achievable timing resolution is non-negligible. The presented formalism incorporates an accurate, analytical probability density function (PDF) of optical transit time within the crystal to obtain a purely mathematical expression of the CRLB with high-aspect-ratio (HAR) scintillation detectors. This approach enables the statistical limit on timing resolution performance to be analytically expressed for clinically-relevant PET scintillation detectors without requiring Monte Carlo simulation-generated photon transport time distributions. The analytically calculated optical transport PDF was compared with detailed light transport simulations, and excellent agreement was found between the two. The coincidence timing resolution (CTR) between two 3×3×20 mm3 LYSO:Ce crystals coupled to analogue SiPMs was experimentally measured to be 162±1 ps FWHM, approaching the analytically calculated lower bound within 6.5%. PMID:26083559

Analytical calculation of the lower bound on timing resolution for PET scintillation detectors comprising high-aspect-ratio crystal elements

NASA Astrophysics Data System (ADS)

Cates, Joshua W.; Vinke, Ruud; Levin, Craig S.

2015-07-01

Excellent timing resolution is required to enhance the signal-to-noise ratio (SNR) gain available from the incorporation of time-of-flight (ToF) information in image reconstruction for positron emission tomography (PET). As the detector’s timing resolution improves, so does SNR, reconstructed image quality, and accuracy. This directly impacts the challenging detection and quantification tasks in the clinic. The recognition of these benefits has spurred efforts within the molecular imaging community to determine to what extent the timing resolution of scintillation detectors can be improved and develop near-term solutions for advancing ToF-PET. Presented in this work, is a method for calculating the Cramér-Rao lower bound (CRLB) on timing resolution for scintillation detectors with long crystal elements, where the influence of the variation in optical path length of scintillation light on achievable timing resolution is non-negligible. The presented formalism incorporates an accurate, analytical probability density function (PDF) of optical transit time within the crystal to obtain a purely mathematical expression of the CRLB with high-aspect-ratio (HAR) scintillation detectors. This approach enables the statistical limit on timing resolution performance to be analytically expressed for clinically-relevant PET scintillation detectors without requiring Monte Carlo simulation-generated photon transport time distributions. The analytically calculated optical transport PDF was compared with detailed light transport simulations, and excellent agreement was found between the two. The coincidence timing resolution (CTR) between two 3× 3× 20 mm3 LYSO:Ce crystals coupled to analogue SiPMs was experimentally measured to be 162+/- 1 ps FWHM, approaching the analytically calculated lower bound within 6.5%.

Studies of relative gain and timing response of fine-mesh photomultiplier tubes in high magnetic fields

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sulkosky, V.; Allison, L.; Barber, C.

We investigated the use of Hamamatsu fine-mesh photomultiplier tube assemblies H6152-70 and H6614-70 with regards to their gain and timing resolution in magnetic fields up to 1.9 T. Our results show that the H6614-70 assembly can operate reliably in magnetic fields exceeding 1.5 T, while preserving a reasonable timing resolution even with a gain reduction of a factor of ~100. The reduction of the relative gain of the H6152-70 is similar to the H6614-70's near 1.5 T, but its timing resolution worsens considerably at this high field.

Coincidence velocity map imaging using Tpx3Cam, a time stamping optical camera with 1.5 ns timing resolution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao, Arthur; van Beuzekom, Martin; Bouwens, Bram

Here, we demonstrate a coincidence velocity map imaging apparatus equipped with a novel time-stamping fast optical camera, Tpx3Cam, whose high sensitivity and nanosecond timing resolution allow for simultaneous position and time-of-flight detection. This single detector design is simple, flexible, and capable of highly differential measurements. We show detailed characterization of the camera and its application in strong field ionization experiments.

Coincidence velocity map imaging using Tpx3Cam, a time stamping optical camera with 1.5 ns timing resolution

DOE PAGES

Zhao, Arthur; van Beuzekom, Martin; Bouwens, Bram; ...

2017-11-07

Here, we demonstrate a coincidence velocity map imaging apparatus equipped with a novel time-stamping fast optical camera, Tpx3Cam, whose high sensitivity and nanosecond timing resolution allow for simultaneous position and time-of-flight detection. This single detector design is simple, flexible, and capable of highly differential measurements. We show detailed characterization of the camera and its application in strong field ionization experiments.

Real-time high-resolution heterodyne-based measurements of spectral dynamics in fibre lasers

PubMed Central

Sugavanam, Srikanth; Fabbri, Simon; Le, Son Thai; Lobach, Ivan; Kablukov, Sergey; Khorev, Serge; Churkin, Dmitry

2016-01-01

Conventional tools for measurement of laser spectra (e.g. optical spectrum analysers) capture data averaged over a considerable time period. However, the generation spectrum of many laser types may involve spectral dynamics whose relatively fast time scale is determined by their cavity round trip period, calling for instrumentation featuring both high temporal and spectral resolution. Such real-time spectral characterisation becomes particularly challenging if the laser pulses are long, or they have continuous or quasi-continuous wave radiation components. Here we combine optical heterodyning with a technique of spatio-temporal intensity measurements that allows the characterisation of such complex sources. Fast, round-trip-resolved spectral dynamics of cavity-based systems in real-time are obtained, with temporal resolution of one cavity round trip and frequency resolution defined by its inverse (85 ns and 24 MHz respectively are demonstrated). We also show how under certain conditions for quasi-continuous wave sources, the spectral resolution could be further increased by a factor of 100 by direct extraction of phase information from the heterodyned dynamics or by using double time scales within the spectrogram approach. PMID:26984634

A generic framework for internet-based interactive applications of high-resolution 3-D medical image data.

PubMed

Liu, Danzhou; Hua, Kien A; Sugaya, Kiminobu

2008-09-01

With the advances in medical imaging devices, large volumes of high-resolution 3-D medical image data have been produced. These high-resolution 3-D data are very large in size, and severely stress storage systems and networks. Most existing Internet-based 3-D medical image interactive applications therefore deal with only low- or medium-resolution image data. While it is possible to download the whole 3-D high-resolution image data from the server and perform the image visualization and analysis at the client site, such an alternative is infeasible when the high-resolution data are very large, and many users concurrently access the server. In this paper, we propose a novel framework for Internet-based interactive applications of high-resolution 3-D medical image data. Specifically, we first partition the whole 3-D data into buckets, remove the duplicate buckets, and then, compress each bucket separately. We also propose an index structure for these buckets to efficiently support typical queries such as 3-D slicer and region of interest, and only the relevant buckets are transmitted instead of the whole high-resolution 3-D medical image data. Furthermore, in order to better support concurrent accesses and to improve the average response time, we also propose techniques for efficient query processing, incremental transmission, and client sharing. Our experimental study in simulated and realistic environments indicates that the proposed framework can significantly reduce storage and communication requirements, and can enable real-time interaction with remote high-resolution 3-D medical image data for many concurrent users.

A long-time, high spatiotemporal resolution optical recording system for membrane potential activity via real-time writing to the hard disk.

PubMed

Hirota, Akihiko; Ito, Shin-ichi

2006-06-01

Using real-time hard disk recording, we have developed an optical system for the long-duration detection of changes in membrane potential from 1,020 sites with a high temporal resolution. The signal-to-noise ratio was sufficient for analyzing the spreading pattern of excitatory waves in frog atria in a single sweep.

Obtaining high-resolution velocity spectra using weighted semblance

NASA Astrophysics Data System (ADS)

Ebrahimi, Saleh; Kahoo, Amin Roshandel; Porsani, Milton J.; Kalateh, Ali Nejati

2017-02-01

Velocity analysis employs coherency measurement along a hyperbolic or non-hyperbolic trajectory time window to build velocity spectra. Accuracy and resolution are strictly related to the method of coherency measurements. Semblance, the most common coherence measure, has poor resolution velocity which affects one's ability to distinguish and pick distinct peaks. Increase the resolution of the semblance velocity spectra causes the accuracy of estimated velocity for normal moveout correction and stacking is improved. The low resolution of semblance spectra depends on its low sensitivity to velocity changes. In this paper, we present a new weighted semblance method that ensures high-resolution velocity spectra. To increase the resolution of semblance spectra, we introduce two weighting functions based on the first to second singular values ratio of the time window and the position of the seismic wavelet in the time window to the semblance equation. We test the method on both synthetic and real field data to compare the resolution of weighted and conventional semblance methods. Numerical examples with synthetic and real seismic data indicate that the new proposed weighted semblance method provides higher resolution than conventional semblance and can separate the reflectors which are mixed in the semblance spectrum.

Signal Decomposition of High Resolution Time Series River Data to Separate Local and Regional Components of Conductivity

EPA Science Inventory

Signal processing techniques were applied to high-resolution time series data obtained from conductivity loggers placed upstream and downstream of an oil and gas wastewater treatment facility along a river. Data was collected over 14-60 days. The power spectral density was us...

Building Change Detection in Very High Resolution Satellite Stereo Image Time Series

NASA Astrophysics Data System (ADS)

Tian, J.; Qin, R.; Cerra, D.; Reinartz, P.

2016-06-01

There is an increasing demand for robust methods on urban sprawl monitoring. The steadily increasing number of high resolution and multi-view sensors allows producing datasets with high temporal and spatial resolution; however, less effort has been dedicated to employ very high resolution (VHR) satellite image time series (SITS) to monitor the changes in buildings with higher accuracy. In addition, these VHR data are often acquired from different sensors. The objective of this research is to propose a robust time-series data analysis method for VHR stereo imagery. Firstly, the spatial-temporal information of the stereo imagery and the Digital Surface Models (DSMs) generated from them are combined, and building probability maps (BPM) are calculated for all acquisition dates. In the second step, an object-based change analysis is performed based on the derivative features of the BPM sets. The change consistence between object-level and pixel-level are checked to remove any outlier pixels. Results are assessed on six pairs of VHR satellite images acquired within a time span of 7 years. The evaluation results have proved the efficiency of the proposed method.

Time-resolved High Spectral Resolution Observation of 2MASSW J0746425+200032AB

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Ji; Mawet, Dimitri; Prato, Lisa, E-mail: ji.wang@caltech.edu

Many brown dwarfs (BDs) exhibit photometric variability at levels from tenths to tens of percents. The photometric variability is related to magnetic activity or patchy cloud coverage, characteristic of BDs near the L–T transition. Time-resolved spectral monitoring of BDs provides diagnostics of cloud distribution and condensate properties. However, current time-resolved spectral studies of BDs are limited to low spectral resolution ( R ∼ 100) with the exception of the study of Luhman 16 AB at a resolution of 100,000 using the VLT+CRIRES. This work yielded the first map of BD surface inhomogeneity, highlighting the importance and unique contribution of highmore » spectral resolution observations. Here, we report on the time-resolved high spectral resolution observations of a nearby BD binary, 2MASSW J0746425+200032AB. We find no coherent spectral variability that is modulated with rotation. Based on simulations, we conclude that the coverage of a single spot on 2MASSW J0746425+200032AB is smaller than 1% or 6.25% if spot contrast is 50% or 80% of its surrounding flux, respectively. Future high spectral resolution observations aided by adaptive optics systems can put tighter constraints on the spectral variability of 2MASSW J0746425+200032AB and other nearby BDs.« less

SU-F-T-559: High-Resolution Scintillating Fiber Array for In-Vivo Real-Time SRS and SBRT Patient QA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Knewtson, T; Pokhrel, S; University of Tennessee Health Science Center, Memphis, TN

2016-06-15

Purpose: A high-resolution scintillating fiber detector was built for in-vivo real-time patient specific quality assurance (QA). The detector is designed for stereotactic body radiotherapy (SBRT) and stereotactic radiosurgery (SRS) to monitor treatment delivery and detect real-time deviations from planned dose to increase patient safety and treatment accuracy. Methods: The detector consists of two high-density scintillating fiber arrays layered to form an X-Y grid which can be attached to the accessory tray of a medical linac for SBRT and cone SRS treatment QA. Fiber arrays consist of 128 scintillating fibers embedded within a precision-machined, high-transmission polymer substrate with 0.8mm pitch. Themore » fibers are coupled on both ends to high-sensitivity photodetectors and the output is recorded through a high-speed analog-to-digital converter to capture the linac pulse sequence as treatment delivery progresses. The detector has a software controlled 360 degree rotational system to capture angular beam projections for high-resolution beam profile reconstruction. Results: The detector was validated using SRS cone sizes from 6mm to 34mm and MLC defined field sizes from 5×5mm2 to 100×100mm2. The detector output response is linear with dose and is dose rate independent. Each field can be reconstructed accurately with a spatial resolution of 0.8mm and the current beam output is displayed every 50msec. Dosimetric errors of 1% with respect to the treatment plan can be identified and clinically significant deviations from the expected treatment can be displayed in real-time to alert the therapists. Conclusion: The high resolution detector is capable of reconstructing beam profiles in real-time with submillimeter resolution and 1% dose resolution. This system has the ability to project in-vivo both spatial and dosimetric errors during SBRT and SRS treatments when only a non-clinically significant fraction of the intended dose was delivered. The device has the potential to establish new standards for in-vivo patient specific QA.« less

Robust High-Resolution Cloth Using Parallelism, History-Based Collisions and Accurate Friction

PubMed Central

Selle, Andrew; Su, Jonathan; Irving, Geoffrey; Fedkiw, Ronald

2015-01-01

In this paper we simulate high resolution cloth consisting of up to 2 million triangles which allows us to achieve highly detailed folds and wrinkles. Since the level of detail is also influenced by object collision and self collision, we propose a more accurate model for cloth-object friction. We also propose a robust history-based repulsion/collision framework where repulsions are treated accurately and efficiently on a per time step basis. Distributed memory parallelism is used for both time evolution and collisions and we specifically address Gauss-Seidel ordering of repulsion/collision response. This algorithm is demonstrated by several high-resolution and high-fidelity simulations. PMID:19147895

A High-Resolution Time-of-Flight Clinical PET Detection System Using a Gapless PMT-Quadrant-Sharing Method

NASA Astrophysics Data System (ADS)

Wong, Wai-Hoi; Li, Hongdi; Zhang, Yuxuan; Ramirez, Rocio; An, Shaohui; Wang, Chao; Liu, Shitao; Dong, Yun; Baghaei, Hossain

2015-10-01

We developed a high-resolution Photomultiplier-Quadrant-Sharing (PQS) PET system for human imaging. This system is made up of 24 detector panels. Each panel (bank) consists of 3 ×7 detector blocks, and each block has 16 ×16 LYSO crystals of 2.35 ×2.35 ×15.2 mm3. We used a novel detector-grinding scheme that is compatible with the PQS detector-pixel-decoding requirements to make a gapless cylindrical detector ring for maximizing detection efficiency while delivering an ultrahigh spatial-resolution for a whole-body PET camera with a ring diameter of 87 cm and axial field of view of 27.6 cm. This grinding scheme enables two adjacent gapless panels to share one row of the PMTs to extend the PQS configuration beyond one panel and thus maximize the economic benefit (in PMT usage) of the PQS design. The entire detector ring has 129,024 crystals, all of which are clearly decoded using only 576 PMTs (38-mm diameter). Thus, each PMT on average decodes 224 crystals to achieve a high crystal-pitch resolution of 2.44 mm ×2.44 mm. The detector blocks were mass-produced with our slab-sandwich-slice technique using a set of optimized mirror-film patterns (between crystals) to maximize light output and achieve high spatial and timing resolution. This detection system with time-of-flight capability was placed in a human PET/CT gantry. The reconstructed image resolution of the system was about 2.87 mm using 2D-filtered back-projection. The time-of-flight resolution was 473 ps. The preliminary images of phantoms and clinical studies presented in this work demonstrate the capability of this new PET/CT system to produce high-quality images.

Analysis of the impact of spatial resolution on land/water classifications using high-resolution aerial imagery

USGS Publications Warehouse

Enwright, Nicholas M.; Jones, William R.; Garber, Adrienne L.; Keller, Matthew J.

2014-01-01

Long-term monitoring efforts often use remote sensing to track trends in habitat or landscape conditions over time. To most appropriately compare observations over time, long-term monitoring efforts strive for consistency in methods. Thus, advances and changes in technology over time can present a challenge. For instance, modern camera technology has led to an increasing availability of very high-resolution imagery (i.e. submetre and metre) and a shift from analogue to digital photography. While numerous studies have shown that image resolution can impact the accuracy of classifications, most of these studies have focused on the impacts of comparing spatial resolution changes greater than 2 m. Thus, a knowledge gap exists on the impacts of minor changes in spatial resolution (i.e. submetre to about 1.5 m) in very high-resolution aerial imagery (i.e. 2 m resolution or less). This study compared the impact of spatial resolution on land/water classifications of an area dominated by coastal marsh vegetation in Louisiana, USA, using 1:12,000 scale colour-infrared analogue aerial photography (AAP) scanned at four different dot-per-inch resolutions simulating ground sample distances (GSDs) of 0.33, 0.54, 1, and 2 m. Analysis of the impact of spatial resolution on land/water classifications was conducted by exploring various spatial aspects of the classifications including density of waterbodies and frequency distributions in waterbody sizes. This study found that a small-magnitude change (1–1.5 m) in spatial resolution had little to no impact on the amount of water classified (i.e. percentage mapped was less than 1.5%), but had a significant impact on the mapping of very small waterbodies (i.e. waterbodies ≤ 250 m2). These findings should interest those using temporal image classifications derived from very high-resolution aerial photography as a component of long-term monitoring programs.

High-resolution short-exposure small-animal laboratory x-ray phase-contrast tomography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Larsson, Daniel H.; Vågberg, William; Yaroshenko, Andre

X-ray computed tomography of small animals and their organs is an essential tool in basic and preclinical biomedical research. In both phase-contrast and absorption tomography high spatial resolution and short exposure times are of key importance. However, the observable spatial resolutions and achievable exposure times are presently limited by system parameters rather than more fundamental constraints like, e.g., dose. Here we demonstrate laboratory tomography with few-ten μm spatial resolution and few-minute exposure time at an acceptable dose for small-animal imaging, both with absorption contrast and phase contrast. The method relies on a magnifying imaging scheme in combination with a high-powermore » small-spot liquid-metal-jet electron-impact source. Lastly, the tomographic imaging is demonstrated on intact mouse, phantoms and excised lungs, both healthy and with pulmonary emphysema.« less

High-resolution short-exposure small-animal laboratory x-ray phase-contrast tomography

DOE PAGES

Larsson, Daniel H.; Vågberg, William; Yaroshenko, Andre; ...

2016-12-13

X-ray computed tomography of small animals and their organs is an essential tool in basic and preclinical biomedical research. In both phase-contrast and absorption tomography high spatial resolution and short exposure times are of key importance. However, the observable spatial resolutions and achievable exposure times are presently limited by system parameters rather than more fundamental constraints like, e.g., dose. Here we demonstrate laboratory tomography with few-ten μm spatial resolution and few-minute exposure time at an acceptable dose for small-animal imaging, both with absorption contrast and phase contrast. The method relies on a magnifying imaging scheme in combination with a high-powermore » small-spot liquid-metal-jet electron-impact source. Lastly, the tomographic imaging is demonstrated on intact mouse, phantoms and excised lungs, both healthy and with pulmonary emphysema.« less

Development of a low energy electron spectrometer for SCOPE

NASA Astrophysics Data System (ADS)

Tominaga, Yuu; Saito, Yoshifumi; Yokota, Shoichiro

We are newly developing a low-energy charged particle analyzer for the future satellite mission SCOPE (cross Scale COupling in the Plasma universE). The main purpose of the mission is to understand the cross scale coupling between macroscopic MHD scale phenomena and microscopic ion and electron-scale phenomena. In order to under-stand the dynamics of plasma in small scales, we need to observe the plasma with an analyzer which has high time resolution. For ion-scale phenomena, the time resolution must be as high as ion cyclotron frequency (-10 sec) in Earth's magnetosphere. However, for electron-scale phe-nomena, the time resolution must be as high as electron cyclotron frequency (-1 msec). The GEOTAIL satellite that observes Earth's magnetosphere has the analyzer whose time resolution is 12 sec, so the satellite can observe ion-scale phenomena. However in the SCOPE mission, we will go further to observe electron-scale phenomena. Then we need analyzers that have at least several msec time resolution. Besides, we need to make the analyzer as small as possible for the volume and weight restrictions of the satellite. The diameter of the top-hat analyzer must be smaller than 20 cm. In this study, we are developing an electrostatic analyzer that meets such requirements using numerical simulations. The electrostatic analyzer is a spherical/toroidal top-hat electrostatic analyzer with three nested spherical/toroidal deflectors. Using these deflectors, the analyzer measures charged particles simultaneously in two different energy ranges. Therefore time res-olution of the analyzer can be doubled. With the analyzer, we will measure energies from 10 eV to 22.5 keV. In order to obtain three-dimensional distribution functions of low energy parti-cles, the analyzer must have 4-pi str field of view. Conventional electrostatic analyzers use the spacecraft spin to have 4-pi field of view. So the time resolution of the analyzer depends on the spin frequency of the spacecraft. However, we cannot secure the several msec time resolution by using the spacecraft spin. In the SCOPE mission, we set 8 pairs of two nested electrostatic analyzers on each side of the spacecraft, which enable us to secure 4-pi field of view altogether. Then the time resolution of the analyzer does not depend on the spacecraft spin. Given that the sampling time of the analyzer is 0.5 msec, the time resolution of the analyzer can be 8 msec. In order to secure the time resolution as high as 10 msec, the geometric factor of the analyzer has to be as high as 8*10-3 (cm2 str eV/eV/22.5deg). Higher geometric factor requires bigger instrument. However, we have to reduce the volume and weight of the instrument to set it on the satellite. Under these restrictions, we have realized the analyzer which has the geometric factors of 7.5*10-3 (cm2 str eV/eV/22.5deg) (inner sphere) and 10.0*10-3 (cm2 str eV/eV/22.5deg) (outer sphere) with diameter of 17.4 cm.

High-Resolution Near Real-Time Drought Monitoring in South Asia

NASA Astrophysics Data System (ADS)

Aadhar, S.; Mishra, V.

2017-12-01

Drought in South Asia affect food and water security and pose challenges for millions of people. For policy-making, planning and management of water resources at the sub-basin or administrative levels, high-resolution datasets of precipitation and air temperature are required in near-real time. Here we develop a high resolution (0.05 degree) bias-corrected precipitation and temperature data that can be used to monitor near real-time drought conditions over South Asia. Moreover, the dataset can be used to monitor climatic extremes (heat waves, cold waves, dry and wet anomalies) in South Asia. A distribution mapping method was applied to correct bias in precipitation and air temperature (maximum and minimum), which performed well compared to the other bias correction method based on linear scaling. Bias-corrected precipitation and temperature data were used to estimate Standardized precipitation index (SPI) and Standardized Precipitation Evapotranspiration Index (SPEI) to assess the historical and current drought conditions in South Asia. We evaluated drought severity and extent against the satellite-based Normalized Difference Vegetation Index (NDVI) anomalies and satellite-driven Drought Severity Index (DSI) at 0.05˚. We find that the bias-corrected high-resolution data can effectively capture observed drought conditions as shown by the satellite-based drought estimates. High resolution near real-time dataset can provide valuable information for decision-making at district and sub- basin levels.

Adaptive optics with pupil tracking for high resolution retinal imaging

PubMed Central

Sahin, Betul; Lamory, Barbara; Levecq, Xavier; Harms, Fabrice; Dainty, Chris

2012-01-01

Adaptive optics, when integrated into retinal imaging systems, compensates for rapidly changing ocular aberrations in real time and results in improved high resolution images that reveal the photoreceptor mosaic. Imaging the retina at high resolution has numerous potential medical applications, and yet for the development of commercial products that can be used in the clinic, the complexity and high cost of the present research systems have to be addressed. We present a new method to control the deformable mirror in real time based on pupil tracking measurements which uses the default camera for the alignment of the eye in the retinal imaging system and requires no extra cost or hardware. We also present the first experiments done with a compact adaptive optics flood illumination fundus camera where it was possible to compensate for the higher order aberrations of a moving model eye and in vivo in real time based on pupil tracking measurements, without the real time contribution of a wavefront sensor. As an outcome of this research, we showed that pupil tracking can be effectively used as a low cost and practical adaptive optics tool for high resolution retinal imaging because eye movements constitute an important part of the ocular wavefront dynamics. PMID:22312577

Adaptive optics with pupil tracking for high resolution retinal imaging.

PubMed

Sahin, Betul; Lamory, Barbara; Levecq, Xavier; Harms, Fabrice; Dainty, Chris

2012-02-01

Adaptive optics, when integrated into retinal imaging systems, compensates for rapidly changing ocular aberrations in real time and results in improved high resolution images that reveal the photoreceptor mosaic. Imaging the retina at high resolution has numerous potential medical applications, and yet for the development of commercial products that can be used in the clinic, the complexity and high cost of the present research systems have to be addressed. We present a new method to control the deformable mirror in real time based on pupil tracking measurements which uses the default camera for the alignment of the eye in the retinal imaging system and requires no extra cost or hardware. We also present the first experiments done with a compact adaptive optics flood illumination fundus camera where it was possible to compensate for the higher order aberrations of a moving model eye and in vivo in real time based on pupil tracking measurements, without the real time contribution of a wavefront sensor. As an outcome of this research, we showed that pupil tracking can be effectively used as a low cost and practical adaptive optics tool for high resolution retinal imaging because eye movements constitute an important part of the ocular wavefront dynamics.

High frequency, high time resolution time-to-digital converter employing passive resonating circuits.

PubMed

Ripamonti, Giancarlo; Abba, Andrea; Geraci, Angelo

2010-05-01

A method for measuring time intervals accurate to the picosecond range is based on phase measurements of oscillating waveforms synchronous with their beginning and/or end. The oscillation is generated by triggering an LC resonant circuit, whose capacitance is precharged. By using high Q resonators and a final active quenching of the oscillation, it is possible to conjugate high time resolution and a small measurement time, which allows a high measurement rate. Methods for fast analysis of the data are considered and discussed with reference to computing resource requirements, speed, and accuracy. Experimental tests show the feasibility of the method and a time accuracy better than 4 ps rms. Methods aimed at further reducing hardware resources are finally discussed.

A novel ToF-SIMS operation mode for sub 100 nm lateral resolution: Application and performance.

PubMed

Kubicek, Markus; Holzlechner, Gerald; Opitz, Alexander K; Larisegger, Silvia; Hutter, Herbert; Fleig, Jürgen

2014-01-15

A novel operation mode for time of flight-secondary ion mass spectrometry (ToF-SIMS) is described for a TOF.SIMS 5 instrument with a Bi-ion gun. It features sub 100 nm lateral resolution, adjustable primary ion currents and the possibility to measure with high lateral resolution as well as high mass resolution. The adjustment and performance of the novel operation mode are described and compared to established ToF-SIMS operation modes. Several examples of application featuring novel scientific results show the capabilities of the operation mode in terms of lateral resolution, accuracy of isotope analysis of oxygen, and combination of high lateral and mass resolution. The relationship between high lateral resolution and operation of SIMS in static mode is discussed.

Current position of high-resolution MS for drug quantification in clinical & forensic toxicology.

PubMed

Meyer, Markus R; Helfer, Andreas G; Maurer, Hans H

2014-08-01

This paper reviews high-resolution MS approaches published from January 2011 until March 2014 for the quantification of drugs (of abuse) and/or their metabolites in biosamples using LC-MS with time-of-flight or Orbitrap™ mass analyzers. Corresponding approaches are discussed including sample preparation and mass spectral settings. The advantages and limitations of high-resolution MS for drug quantification, as well as the demand for a certain resolution or a specific mass accuracy are also explored.

Light-sheet Bayesian microscopy enables deep-cell super-resolution imaging of heterochromatin in live human embryonic stem cells.

PubMed

Hu, Ying S; Zhu, Quan; Elkins, Keri; Tse, Kevin; Li, Yu; Fitzpatrick, James A J; Verma, Inder M; Cang, Hu

2013-01-01

Heterochromatin in the nucleus of human embryonic cells plays an important role in the epigenetic regulation of gene expression. The architecture of heterochromatin and its dynamic organization remain elusive because of the lack of fast and high-resolution deep-cell imaging tools. We enable this task by advancing instrumental and algorithmic implementation of the localization-based super-resolution technique. We present light-sheet Bayesian super-resolution microscopy (LSBM). We adapt light-sheet illumination for super-resolution imaging by using a novel prism-coupled condenser design to illuminate a thin slice of the nucleus with high signal-to-noise ratio. Coupled with a Bayesian algorithm that resolves overlapping fluorophores from high-density areas, we show, for the first time, nanoscopic features of the heterochromatin structure in both fixed and live human embryonic stem cells. The enhanced temporal resolution allows capturing the dynamic change of heterochromatin with a lateral resolution of 50-60 nm on a time scale of 2.3 s. Light-sheet Bayesian microscopy opens up broad new possibilities of probing nanometer-scale nuclear structures and real-time sub-cellular processes and other previously difficult-to-access intracellular regions of living cells at the single-molecule, and single cell level.

Light-sheet Bayesian microscopy enables deep-cell super-resolution imaging of heterochromatin in live human embryonic stem cells

PubMed Central

Hu, Ying S; Zhu, Quan; Elkins, Keri; Tse, Kevin; Li, Yu; Fitzpatrick, James A J; Verma, Inder M; Cang, Hu

2016-01-01

Background Heterochromatin in the nucleus of human embryonic cells plays an important role in the epigenetic regulation of gene expression. The architecture of heterochromatin and its dynamic organization remain elusive because of the lack of fast and high-resolution deep-cell imaging tools. We enable this task by advancing instrumental and algorithmic implementation of the localization-based super-resolution technique. Results We present light-sheet Bayesian super-resolution microscopy (LSBM). We adapt light-sheet illumination for super-resolution imaging by using a novel prism-coupled condenser design to illuminate a thin slice of the nucleus with high signal-to-noise ratio. Coupled with a Bayesian algorithm that resolves overlapping fluorophores from high-density areas, we show, for the first time, nanoscopic features of the heterochromatin structure in both fixed and live human embryonic stem cells. The enhanced temporal resolution allows capturing the dynamic change of heterochromatin with a lateral resolution of 50–60 nm on a time scale of 2.3 s. Conclusion Light-sheet Bayesian microscopy opens up broad new possibilities of probing nanometer-scale nuclear structures and real-time sub-cellular processes and other previously difficult-to-access intracellular regions of living cells at the single-molecule, and single cell level. PMID:27795878

High-resolution Bent-crystal Spectrometer for the Ultra-soft X-ray Region

DOE R&D Accomplishments Database

Beiersdorfer, P.; von Goeler, S.; Bitter, M.; Hill, K. W.; Hulse, R. A.; Walling, R. S.

1988-10-01

A multichannel vacuum Brag-crystal spectrometer has been developed for high-resolution measurements of the line emission from tokamak plasmas in the wavelength region between 4 and 25 angstrom. The spectrometer employs a bent crystal in Johann geometry and a microchannel-plate intensified photodiode array. The instrument is capable of measuring high-resolution spectra (lambda/..delta..lambda approx. 3000) with fast time resolution (4 msec per spectrum) and good spatial resolution (3 cm). The spectral bandwidth is ..delta..lambda/lambda{sub 0} = 8 angstrom. A simple tilt mechanism allows access to different wavelength intervals. In order to illustrate the utility of the new spectrometer, time- and space-resolved measurements of the n = 3 to n = 2 spectrum of selenium from the Princeton Large Torus tokamak plasmas are presented. The data are used to determine the plasma transport parameters and to infer the radial distribution of fluorinelike, neonlike, and sodiumlike ions of selenium in the plasma. The new ultra-soft x-ray spectrometer has thus enabled us to demonstrate the utility of high-resolution L-shell spectroscopy of neonlike ions as a fusion diagnostic.

TerraClimate, a high-resolution global dataset of monthly climate and climatic water balance from 1958-2015.

PubMed

Abatzoglou, John T; Dobrowski, Solomon Z; Parks, Sean A; Hegewisch, Katherine C

2018-01-09

We present TerraClimate, a dataset of high-spatial resolution (1/24°, ~4-km) monthly climate and climatic water balance for global terrestrial surfaces from 1958-2015. TerraClimate uses climatically aided interpolation, combining high-spatial resolution climatological normals from the WorldClim dataset, with coarser resolution time varying (i.e., monthly) data from other sources to produce a monthly dataset of precipitation, maximum and minimum temperature, wind speed, vapor pressure, and solar radiation. TerraClimate additionally produces monthly surface water balance datasets using a water balance model that incorporates reference evapotranspiration, precipitation, temperature, and interpolated plant extractable soil water capacity. These data provide important inputs for ecological and hydrological studies at global scales that require high spatial resolution and time varying climate and climatic water balance data. We validated spatiotemporal aspects of TerraClimate using annual temperature, precipitation, and calculated reference evapotranspiration from station data, as well as annual runoff from streamflow gauges. TerraClimate datasets showed noted improvement in overall mean absolute error and increased spatial realism relative to coarser resolution gridded datasets.

TerraClimate, a high-resolution global dataset of monthly climate and climatic water balance from 1958-2015

NASA Astrophysics Data System (ADS)

Abatzoglou, John T.; Dobrowski, Solomon Z.; Parks, Sean A.; Hegewisch, Katherine C.

2018-01-01

We present TerraClimate, a dataset of high-spatial resolution (1/24°, ~4-km) monthly climate and climatic water balance for global terrestrial surfaces from 1958-2015. TerraClimate uses climatically aided interpolation, combining high-spatial resolution climatological normals from the WorldClim dataset, with coarser resolution time varying (i.e., monthly) data from other sources to produce a monthly dataset of precipitation, maximum and minimum temperature, wind speed, vapor pressure, and solar radiation. TerraClimate additionally produces monthly surface water balance datasets using a water balance model that incorporates reference evapotranspiration, precipitation, temperature, and interpolated plant extractable soil water capacity. These data provide important inputs for ecological and hydrological studies at global scales that require high spatial resolution and time varying climate and climatic water balance data. We validated spatiotemporal aspects of TerraClimate using annual temperature, precipitation, and calculated reference evapotranspiration from station data, as well as annual runoff from streamflow gauges. TerraClimate datasets showed noted improvement in overall mean absolute error and increased spatial realism relative to coarser resolution gridded datasets.

Precision Timing Calorimeter for High Energy Physics

DOE PAGES

Anderson, Dustin; Apresyan, Artur; Bornheim, Adolf; ...

2016-04-01

Here, we present studies on the performance and characterization of the time resolution of LYSO-based calorimeters. Results for an LYSO sampling calorimeter and an LYSO-tungsten Shashlik calorimeter are presented. We also demonstrate that a time resolution of 30 ps is achievable for the LYSO sampling calorimeter. Timing calorimetry is described as a tool for mitigating the effects due to the large number of simultaneous interactions in the high luminosity environment foreseen for the Large Hadron Collider.

The viability of ADVANTG deterministic method for synthetic radiography generation

NASA Astrophysics Data System (ADS)

Bingham, Andrew; Lee, Hyoung K.

2018-07-01

Fast simulation techniques to generate synthetic radiographic images of high resolution are helpful when new radiation imaging systems are designed. However, the standard stochastic approach requires lengthy run time with poorer statistics at higher resolution. The investigation of the viability of a deterministic approach to synthetic radiography image generation was explored. The aim was to analyze a computational time decrease over the stochastic method. ADVANTG was compared to MCNP in multiple scenarios including a small radiography system prototype, to simulate high resolution radiography images. By using ADVANTG deterministic code to simulate radiography images the computational time was found to decrease 10 to 13 times compared to the MCNP stochastic approach while retaining image quality.

Optimization of high count rate event counting detector with Microchannel Plates and quad Timepix readout

NASA Astrophysics Data System (ADS)

Tremsin, A. S.; Vallerga, J. V.; McPhate, J. B.; Siegmund, O. H. W.

2015-07-01

Many high resolution event counting devices process one event at a time and cannot register simultaneous events. In this article a frame-based readout event counting detector consisting of a pair of Microchannel Plates and a quad Timepix readout is described. More than 104 simultaneous events can be detected with a spatial resolution of 55 μm, while >103 simultaneous events can be detected with <10 μm spatial resolution when event centroiding is implemented. The fast readout electronics is capable of processing >1200 frames/sec, while the global count rate of the detector can exceed 5×108 particles/s when no timing information on every particle is required. For the first generation Timepix readout, the timing resolution is limited by the Timepix clock to 10-20 ns. Optimization of the MCP gain, rear field voltage and Timepix threshold levels are crucial for the device performance and that is the main subject of this article. These devices can be very attractive for applications where the photon/electron/ion/neutron counting with high spatial and temporal resolution is required, such as energy resolved neutron imaging, Time of Flight experiments in lidar applications, experiments on photoelectron spectroscopy and many others.

A multiplexed TOF and DOI capable PET detector using a binary position sensitive network.

PubMed

Bieniosek, M F; Cates, J W; Levin, C S

2016-11-07

Time of flight (TOF) and depth of interaction (DOI) capabilities can significantly enhance the quality and uniformity of positron emission tomography (PET) images. Many proposed TOF/DOI PET detectors require complex readout systems using additional photosensors, active cooling, or waveform sampling. This work describes a high performance, low complexity, room temperature TOF/DOI PET module. The module uses multiplexed timing channels to significantly reduce the electronic readout complexity of the PET detector while maintaining excellent timing, energy, and position resolution. DOI was determined using a two layer light sharing scintillation crystal array with a novel binary position sensitive network. A 20 mm effective thickness LYSO crystal array with four 3 mm  ×  3 mm silicon photomultipliers (SiPM) read out by a single timing channel, one energy channel and two position channels achieved a full width half maximum (FWHM) coincidence time resolution of 180  ±  2 ps with 10 mm of DOI resolution and 11% energy resolution. With sixteen 3 mm  ×  3 mm SiPMs read out by a single timing channel, one energy channel and four position channels a coincidence time resolution 204  ±  1 ps was achieved with 10 mm of DOI resolution and 15% energy resolution. The methods presented here could significantly simplify the construction of high performance TOF/DOI PET detectors.

An Efficient Adaptive Window Size Selection Method for Improving Spectrogram Visualization.

PubMed

Nisar, Shibli; Khan, Omar Usman; Tariq, Muhammad

2016-01-01

Short Time Fourier Transform (STFT) is an important technique for the time-frequency analysis of a time varying signal. The basic approach behind it involves the application of a Fast Fourier Transform (FFT) to a signal multiplied with an appropriate window function with fixed resolution. The selection of an appropriate window size is difficult when no background information about the input signal is known. In this paper, a novel empirical model is proposed that adaptively adjusts the window size for a narrow band-signal using spectrum sensing technique. For wide-band signals, where a fixed time-frequency resolution is undesirable, the approach adapts the constant Q transform (CQT). Unlike the STFT, the CQT provides a varying time-frequency resolution. This results in a high spectral resolution at low frequencies and high temporal resolution at high frequencies. In this paper, a simple but effective switching framework is provided between both STFT and CQT. The proposed method also allows for the dynamic construction of a filter bank according to user-defined parameters. This helps in reducing redundant entries in the filter bank. Results obtained from the proposed method not only improve the spectrogram visualization but also reduce the computation cost and achieves 87.71% of the appropriate window length selection.

The Substructure of the Solar Corona Observed in the Hi-C Telescope

NASA Technical Reports Server (NTRS)

Winebarger, A.; Cirtain, J.; Golub, L.; DeLuca, E.; Savage, S.; Alexander, C.; Schuler, T.

2014-01-01

In the summer of 2012, the High-resolution Coronal Imager (Hi-C) flew aboard a NASA sounding rocket and collected the highest spatial resolution images ever obtained of the solar corona. One of the goals of the Hi-C flight was to characterize the substructure of the solar corona. We therefore calculate how the intensity scales from a low-resolution (AIA) pixels to high-resolution (Hi-C) pixels for both the dynamic events and "background" emission (meaning, the steady emission over the 5 minutes of data acquisition time). We find there is no evidence of substructure in the background corona; the intensity scales smoothly from low-resolution to high-resolution Hi-C pixels. In transient events, however, the intensity observed with Hi-C is, on average, 2.6 times larger than observed with AIA. This increase in intensity suggests that AIA is not resolving these events. This result suggests a finely structured dynamic corona embedded in a smoothly varying background.

High Resolution Bathymetry Estimation Improvement with Single Image Super-Resolution Algorithm Super-Resolution Forests

DTIC Science & Technology

2017-01-26

Naval Research Laboratory Washington, DC 20375-5320 NRL/MR/5514--17-9692 High Resolution Bathymetry Estimation Improvement with Single Image Super...collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources...gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate

Data center thermal management

DOEpatents

Hamann, Hendrik F.; Li, Hongfei

2016-02-09

Historical high-spatial-resolution temperature data and dynamic temperature sensor measurement data may be used to predict temperature. A first formulation may be derived based on the historical high-spatial-resolution temperature data for determining a temperature at any point in 3-dimensional space. The dynamic temperature sensor measurement data may be calibrated based on the historical high-spatial-resolution temperature data at a corresponding historical time. Sensor temperature data at a plurality of sensor locations may be predicted for a future time based on the calibrated dynamic temperature sensor measurement data. A three-dimensional temperature spatial distribution associated with the future time may be generated based on the forecasted sensor temperature data and the first formulation. The three-dimensional temperature spatial distribution associated with the future time may be projected to a two-dimensional temperature distribution, and temperature in the future time for a selected space location may be forecasted dynamically based on said two-dimensional temperature distribution.

Assessment of a vertical high-resolution distributed-temperature-sensing system in a shallow thermohaline environment

NASA Astrophysics Data System (ADS)

Suárez, F.; Aravena, J. E.; Hausner, M. B.; Childress, A. E.; Tyler, S. W.

2011-01-01

In shallow thermohaline-driven lakes it is important to measure temperature on fine spatial and temporal scales to detect stratification or different hydrodynamic regimes. Raman spectra distributed temperature sensing (DTS) is an approach available to provide high spatial and temporal temperature resolution. A vertical high-resolution DTS system was constructed to overcome the problems of typical methods used in the past, i.e., without disturbing the water column, and with resistance to corrosive environments. This system monitors the temperature profile each 1.1 cm vertically and in time averages as small as 10 s. Temperature resolution as low as 0.035 °C is obtained when the data are collected at 5-min intervals. The vertical high-resolution DTS system is used to monitor the thermal behavior of a salt-gradient solar pond, which is an engineered shallow thermohaline system that allows collection and storage of solar energy for a long period of time. This paper describes a method to quantitatively assess accuracy, precision and other limitations of DTS systems to fully utilize the capacity of this technology. It also presents, for the first time, a method to manually calibrate temperatures along the optical fiber.

Dual-comb spectroscopy of laser-induced plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bergevin, Jenna; Wu, Tsung-Han; Yeak, Jeremy

Dual-comb spectroscopy has become a powerful spectroscopic technique in applications that rely on its broad spectral coverage combined with high frequency resolution capabilities. Experiments to date have primarily focused on detection and analysis of multiple gas species under semi-static conditions, with applications ranging from environmental monitoring of greenhouse gases to high resolution molecular spectroscopy. Here, we utilize dual-comb spectroscopy to demonstrate broadband, high-resolution, and time-resolved measurements in a laser induced plasma for the first time. As a first demonstration, we simultaneously detect trace amounts of Rb and K in solid samples with a single laser ablation shot, with transitions separatedmore » by over 6 THz (13 nm) and spectral resolution sufficient to resolve isotopic and ground state hyperfine splittings of the Rb D2 line. This new spectroscopic approach offers the broad spectral coverage found in the powerful techniques of laser-induced breakdown spectroscopy (LIBS) while providing the high-resolution and accuracy of cw laser-based spectroscopies.« less

Time and space integrating acousto-optic folded spectrum processing for SETI

NASA Technical Reports Server (NTRS)

Wagner, K.; Psaltis, D.

1986-01-01

Time and space integrating folded spectrum techniques utilizing acousto-optic devices (AOD) as 1-D input transducers are investigated for a potential application as wideband, high resolution, large processing gain spectrum analyzers in the search for extra-terrestrial intelligence (SETI) program. The space integrating Fourier transform performed by a lens channels the coarse spectral components diffracted from an AOD onto an array of time integrating narrowband fine resolution spectrum analyzers. The pulsing action of a laser diode samples the interferometrically detected output, aliasing the fine resolution components to baseband, as required for the subsequent charge coupled devices (CCD) processing. The raster scan mechanism incorporated into the readout of the CCD detector array is used to unfold the 2-D transform, reproducing the desired high resolution Fourier transform of the input signal.

CNV detection method optimized for high-resolution arrayCGH by normality test.

PubMed

Ahn, Jaegyoon; Yoon, Youngmi; Park, Chihyun; Park, Sanghyun

2012-04-01

High-resolution arrayCGH platform makes it possible to detect small gains and losses which previously could not be measured. However, current CNV detection tools fitted to early low-resolution data are not applicable to larger high-resolution data. When CNV detection tools are applied to high-resolution data, they suffer from high false-positives, which increases validation cost. Existing CNV detection tools also require optimal parameter values. In most cases, obtaining these values is a difficult task. This study developed a CNV detection algorithm that is optimized for high-resolution arrayCGH data. This tool operates up to 1500 times faster than existing tools on a high-resolution arrayCGH of whole human chromosomes which has 42 million probes whose average length is 50 bases, while preserving false positive/negative rates. The algorithm also uses a normality test, thereby removing the need for optimal parameters. To our knowledge, this is the first formulation for CNV detecting problems that results in a near-linear empirical overall complexity for real high-resolution data. Copyright © 2012 Elsevier Ltd. All rights reserved.

Holographic Investigation of Solid Propellant Particulates.

DTIC Science & Technology

1981-12-01

4~ .A*4 ~.Zwe SOUMVV Ch.&4 0IVC&TIN 0 e*9 066so. 4 evt’ o R..e High speed, high resolution motion pictures were taken to compare the cinematic data...propellant. High speed, high resolution motion pictures were taken to compare the cinematic data with that available from the holograms. TABLE OF...of the motor ignition system, the repeatability of the pressure-time trace, and the timing of the cinematic /holographic obser- vation. The current

Basic performance of Mg co-doped new scintillator used for TOF-DOI-PET systems

NASA Astrophysics Data System (ADS)

Kobayashi, Takahiro; Yamamoto, Seiichi; Okumura, Satoshi; Yeom, Jung Yeol; Kamada, Kei; Yoshikawa, Akira

2017-01-01

Phoswich depth-of-interaction (DOI) detectors utilizing multiple scintillators with different decay time are a useful device for developing a high spatial resolution, high sensitivity PET scanner. However, in order to apply pulse shape discrimination (PSD), there are not many combinations of scintillators for which phoswich technique can be implemented. Ce doped Gd3Ga3Al2O12 (GFAG) is a recently developed scintillator with a fast decay time. This scintillator is similar to Ce doped Gd3Al2Ga3O12 (GAGG), which is a promising scintillator for PET detector with high light yield. By stacking these scintillators, it may be possible to realize a high spatial resolution and high timing resolution phoswich DOI detector. Such phoswich DOI detector may be applied to time-of-flight (TOF) systems with high timing performance. Therefore, in this study, we tested the basic performance of the new scintillator -GFAG for use in a TOF phoswich detector. The measured decay time of a GFAG element of 2.9 mmx2.9 mmx10 mm in dimension, which was optically coupled to a photomultiplier tube (PMT), was faster (66 ns) than that of same sized GAGG (103 ns). The energy resolution of the GFAG element was 5.7% FWHM which was slightly worse than that of GAGG with 4.9% FWHM for 662 keV gamma photons without saturation correction. Then we assembled the GFAG and the GAGG crystals in the depth direction to form a 20 mm long phoswich element (GFAG/GAGG). By pulse shape analysis, the two types of scintillators were clearly resolved. Measured timing resolution of a pair of opposing GFAG/GAGG phoswich scintillator coupled to Silicon Photomultipliers (Si-PM) was good with coincidence resolving time of 466 ps FWHM. These results indicate that the GFAG combined with GAGG can be a candidate for TOF-DOI-PET systems.

Post-processing method to reduce noise while preserving high time resolution in aethalometer real-time black carbon data

EPA Science Inventory

Real-time aerosol black carbon (BC) data, presented at time resolutions on the order of seconds to minutes, is desirable in field and source characterization studies measuring rapidly varying concentrations of BC. The Optimized Noise-reduction Averaging (ONA) algorithm has been d...

OpenMP parallelization of a gridded SWAT (SWATG)

NASA Astrophysics Data System (ADS)

Zhang, Ying; Hou, Jinliang; Cao, Yongpan; Gu, Juan; Huang, Chunlin

2017-12-01

Large-scale, long-term and high spatial resolution simulation is a common issue in environmental modeling. A Gridded Hydrologic Response Unit (HRU)-based Soil and Water Assessment Tool (SWATG) that integrates grid modeling scheme with different spatial representations also presents such problems. The time-consuming problem affects applications of very high resolution large-scale watershed modeling. The OpenMP (Open Multi-Processing) parallel application interface is integrated with SWATG (called SWATGP) to accelerate grid modeling based on the HRU level. Such parallel implementation takes better advantage of the computational power of a shared memory computer system. We conducted two experiments at multiple temporal and spatial scales of hydrological modeling using SWATG and SWATGP on a high-end server. At 500-m resolution, SWATGP was found to be up to nine times faster than SWATG in modeling over a roughly 2000 km2 watershed with 1 CPU and a 15 thread configuration. The study results demonstrate that parallel models save considerable time relative to traditional sequential simulation runs. Parallel computations of environmental models are beneficial for model applications, especially at large spatial and temporal scales and at high resolutions. The proposed SWATGP model is thus a promising tool for large-scale and high-resolution water resources research and management in addition to offering data fusion and model coupling ability.

High resolution time-to-space conversion of sub-picosecond pulses at 1.55µm by non-degenerate SFG in PPLN crystal.

PubMed

Shayovitz, Dror; Herrmann, Harald; Sohler, Wolfgang; Ricken, Raimund; Silberhorn, Christine; Marom, Dan M

2012-11-19

We demonstrate high resolution and increased efficiency background-free time-to-space conversion using spectrally resolved non-degenerate and collinear SFG in a bulk PPLN crystal. A serial-to-parallel resolution factor of 95 and a time window of 42 ps were achieved. A 60-fold increase in conversion efficiency slope compared with our previous work using a BBO crystal [D. Shayovitz and D. M. Marom, Opt. Lett. 36, 1957 (2011)] was recorded. Finally the measured 40 GHz narrow linewidth of the output SFG signal implies the possibility to extract phase information by employing coherent detection techniques.

Time-resolved serial crystallography captures high-resolution intermediates of photoactive yellow protein

DOE PAGES

Tenboer, Jason; Basu, Shibom; Zatsepin, Nadia; ...

2014-12-05

We report that serial femtosecond crystallography using ultrashort pulses from X-ray Free Electron Lasers (XFELs) offers the possibility to study light-triggered dynamics of biomolecules. Using microcrystals of the blue light photoreceptor, photoactive yellow protein, as a model system, we present high resolution, time-resolved difference electron density maps of excellent quality with strong features, which allow the determination of structures of reaction intermediates to 1.6 Å resolution. These results open the way to the study of reversible and non-reversible biological reactions on time scales as short as femtoseconds under conditions which maximize the extent of reaction initiation throughout the crystal.

Survey of currently available high-resolution raster graphics systems

NASA Technical Reports Server (NTRS)

Jones, Denise R.

1987-01-01

Presented are data obtained on high-resolution raster graphics engines currently available on the market. The data were obtained through survey responses received from various vendors and also from product literature. The questionnaire developed for this survey was basically a list of characteristics desired in a high performance color raster graphics system which could perform real-time aircraft simulations. Several vendors responded to the survey, with most reporting on their most advanced high-performance, high-resolution raster graphics engine.

Image quality improvement in cone-beam CT using the super-resolution technique.

PubMed

Oyama, Asuka; Kumagai, Shinobu; Arai, Norikazu; Takata, Takeshi; Saikawa, Yusuke; Shiraishi, Kenshiro; Kobayashi, Takenori; Kotoku, Jun'ichi

2018-04-05

This study was conducted to improve cone-beam computed tomography (CBCT) image quality using the super-resolution technique, a method of inferring a high-resolution image from a low-resolution image. This technique is used with two matrices, so-called dictionaries, constructed respectively from high-resolution and low-resolution image bases. For this study, a CBCT image, as a low-resolution image, is represented as a linear combination of atoms, the image bases in the low-resolution dictionary. The corresponding super-resolution image was inferred by multiplying the coefficients and the high-resolution dictionary atoms extracted from planning CT images. To evaluate the proposed method, we computed the root mean square error (RMSE) and structural similarity (SSIM). The resulting RMSE and SSIM between the super-resolution images and the planning CT images were, respectively, as much as 0.81 and 1.29 times better than those obtained without using the super-resolution technique. We used super-resolution technique to improve the CBCT image quality.

Breaking the acoustic diffraction limit via nonlinear effect and thermal confinement for potential deep-tissue high-resolution imaging

PubMed Central

Yuan, Baohong; Pei, Yanbo; Kandukuri, Jayanth

2013-01-01

Our recently developed ultrasound-switchable fluorescence (USF) imaging technique showed that it was feasible to conduct high-resolution fluorescence imaging in a centimeter-deep turbid medium. Because the spatial resolution of this technique highly depends on the ultrasound-induced temperature focal size (UTFS), minimization of UTFS becomes important for further improving the spatial resolution USF technique. In this study, we found that UTFS can be significantly reduced below the diffraction-limited acoustic intensity focal size via nonlinear acoustic effects and thermal confinement by appropriately controlling ultrasound power and exposure time, which can be potentially used for deep-tissue high-resolution imaging. PMID:23479498

Fast-timing Capabilities of Silicon Sensors for the CMS High-Granularity Calorimeter at the High-Luminosity LHC

NASA Astrophysics Data System (ADS)

Akchurin, Nural; CMS Collaboration

2017-11-01

We report on the signal timing capabilities of thin silicon sensors when traversed by multiple simultaneous minimum ionizing particles (MIP). Three different planar sensors, 133, 211, and 285 μm thick in depletion thickness, have been exposed to high energy muons and electrons at CERN. We describe signal shape and timing resolution measurements as well as the response of these devices as a function of the multiplicity of MIPs. We compare these measurements to simulations where possible. We achieve better than 20 ps timing resolution for signals larger than a few tens of MIPs.

New concept high-speed and high-resolution color scanner

NASA Astrophysics Data System (ADS)

Nakashima, Keisuke; Shinoda, Shin'ichi; Konishi, Yoshiharu; Sugiyama, Kenji; Hori, Tetsuya

2003-05-01

We have developed a new concept high-speed and high-resolution color scanner (Blinkscan) using digital camera technology. With our most advanced sub-pixel image processing technology, approximately 12 million pixel image data can be captured. High resolution imaging capability allows various uses such as OCR, color document read, and document camera. The scan time is only about 3 seconds for a letter size sheet. Blinkscan scans documents placed "face up" on its scan stage and without any special illumination lights. Using Blinkscan, a high-resolution color document can be easily inputted into a PC at high speed, a paperless system can be built easily. It is small, and since the occupancy area is also small, setting it on an individual desk is possible. Blinkscan offers the usability of a digital camera and accuracy of a flatbed scanner with high-speed processing. Now, about several hundred of Blinkscan are mainly shipping for the receptionist operation in a bank and a security. We will show the high-speed and high-resolution architecture of Blinkscan. Comparing operation-time with conventional image capture device, the advantage of Blinkscan will make clear. And image evaluation for variety of environment, such as geometric distortions or non-uniformity of brightness, will be made.

Prospects for Electron Imaging with Ultrafast Time Resolution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Armstrong, M R; Reed, B W; Torralva, B R

2007-01-26

Many pivotal aspects of material science, biomechanics, and chemistry would benefit from nanometer imaging with ultrafast time resolution. Here we demonstrate the feasibility of short-pulse electron imaging with t10 nanometer/10 picosecond spatio-temporal resolution, sufficient to characterize phenomena that propagate at the speed of sound in materials (1-10 kilometer/second) without smearing. We outline resolution-degrading effects that occur at high current density followed by strategies to mitigate these effects. Finally, we present a model electron imaging system that achieves 10 nanometer/10 picosecond spatio-temporal resolution.

Evaluation of the sparse coding super-resolution method for improving image quality of up-sampled images in computed tomography

NASA Astrophysics Data System (ADS)

Ota, Junko; Umehara, Kensuke; Ishimaru, Naoki; Ohno, Shunsuke; Okamoto, Kentaro; Suzuki, Takanori; Shirai, Naoki; Ishida, Takayuki

2017-02-01

As the capability of high-resolution displays grows, high-resolution images are often required in Computed Tomography (CT). However, acquiring high-resolution images takes a higher radiation dose and a longer scanning time. In this study, we applied the Sparse-coding-based Super-Resolution (ScSR) method to generate high-resolution images without increasing the radiation dose. We prepared the over-complete dictionary learned the mapping between low- and highresolution patches and seek a sparse representation of each patch of the low-resolution input. These coefficients were used to generate the high-resolution output. For evaluation, 44 CT cases were used as the test dataset. We up-sampled images up to 2 or 4 times and compared the image quality of the ScSR scheme and bilinear and bicubic interpolations, which are the traditional interpolation schemes. We also compared the image quality of three learning datasets. A total of 45 CT images, 91 non-medical images, and 93 chest radiographs were used for dictionary preparation respectively. The image quality was evaluated by measuring peak signal-to-noise ratio (PSNR) and structure similarity (SSIM). The differences of PSNRs and SSIMs between the ScSR method and interpolation methods were statistically significant. Visual assessment confirmed that the ScSR method generated a high-resolution image with sharpness, whereas conventional interpolation methods generated over-smoothed images. To compare three different training datasets, there were no significance between the CT, the CXR and non-medical datasets. These results suggest that the ScSR provides a robust approach for application of up-sampling CT images and yields substantial high image quality of extended images in CT.

High-resolution regional climate model evaluation using variable-resolution CESM over California

NASA Astrophysics Data System (ADS)

Huang, X.; Rhoades, A.; Ullrich, P. A.; Zarzycki, C. M.

2015-12-01

Understanding the effect of climate change at regional scales remains a topic of intensive research. Though computational constraints remain a problem, high horizontal resolution is needed to represent topographic forcing, which is a significant driver of local climate variability. Although regional climate models (RCMs) have traditionally been used at these scales, variable-resolution global climate models (VRGCMs) have recently arisen as an alternative for studying regional weather and climate allowing two-way interaction between these domains without the need for nudging. In this study, the recently developed variable-resolution option within the Community Earth System Model (CESM) is assessed for long-term regional climate modeling over California. Our variable-resolution simulations will focus on relatively high resolutions for climate assessment, namely 28km and 14km regional resolution, which are much more typical for dynamically downscaled studies. For comparison with the more widely used RCM method, the Weather Research and Forecasting (WRF) model will be used for simulations at 27km and 9km. All simulations use the AMIP (Atmospheric Model Intercomparison Project) protocols. The time period is from 1979-01-01 to 2005-12-31 (UTC), and year 1979 was discarded as spin up time. The mean climatology across California's diverse climate zones, including temperature and precipitation, is analyzed and contrasted with the Weather Research and Forcasting (WRF) model (as a traditional RCM), regional reanalysis, gridded observational datasets and uniform high-resolution CESM at 0.25 degree with the finite volume (FV) dynamical core. The results show that variable-resolution CESM is competitive in representing regional climatology on both annual and seasonal time scales. This assessment adds value to the use of VRGCMs for projecting climate change over the coming century and improve our understanding of both past and future regional climate related to fine-scale processes. This assessment is also relevant for addressing the scale limitation of current RCMs or VRGCMs when next-generation model resolution increases to ~10km and beyond.

Conversational high resolution mass spectrographic data reduction

NASA Technical Reports Server (NTRS)

Romiez, M. P.

1973-01-01

A FORTRAN 4 program is described which reduces the data obtained from a high resolution mass spectrograph. The program (1) calculates an accurate mass for each line on the photoplate, and (2) assigns elemental compositions to each accurate mass. The program is intended for use in a time-shared computing environment and makes use of the conversational aspects of time-sharing operating systems.

High resolution positron annihilation induced Auger electron spectroscopy of the CuM 2,3VV-transition and of Cu sub-monolayers on Pd and Fe

NASA Astrophysics Data System (ADS)

Mayer, J.; Hugenschmidt, C.; Schreckenbach, K.

2010-09-01

We present a high resolution positron annihilation induced Auger Electron Spectroscopy (PAES) of the CuM 2,3VV-transition with the unprecedented energy resolution of Δ/EE <1%. This energy resolution and the highly intense positron source NEPOMUC enabled us to resolve the double peak structure with PAES for the first time within a measurement time of only 5.5 h. In addition, sub-monolayers of Cu were deposited on Fe- and Pd-samples in order to investigate the surface selectivity of PAES in comparison with EAES. The extremely high surface selectivity of PAES due to the different positron affinity of Cu and Fe lead to the result that with only 0.96 monolayer of Cu on Fe more than 55% of the emitted Auger electrons stem from Cu, whereas with EAES the Cu Auger fraction amounted to less than 6%.

Compressive light field imaging

NASA Astrophysics Data System (ADS)

Ashok, Amit; Neifeld, Mark A.

2010-04-01

Light field imagers such as the plenoptic and the integral imagers inherently measure projections of the four dimensional (4D) light field scalar function onto a two dimensional sensor and therefore, suffer from a spatial vs. angular resolution trade-off. Programmable light field imagers, proposed recently, overcome this spatioangular resolution trade-off and allow high-resolution capture of the (4D) light field function with multiple measurements at the cost of a longer exposure time. However, these light field imagers do not exploit the spatio-angular correlations inherent in the light fields of natural scenes and thus result in photon-inefficient measurements. Here, we describe two architectures for compressive light field imaging that require relatively few photon-efficient measurements to obtain a high-resolution estimate of the light field while reducing the overall exposure time. Our simulation study shows that, compressive light field imagers using the principal component (PC) measurement basis require four times fewer measurements and three times shorter exposure time compared to a conventional light field imager in order to achieve an equivalent light field reconstruction quality.

High-resolution X-ray crystal structure of bovine H-protein using the high-pressure cryocooling method.

PubMed

Higashiura, Akifumi; Ohta, Kazunori; Masaki, Mika; Sato, Masaru; Inaka, Koji; Tanaka, Hiroaki; Nakagawa, Atsushi

2013-11-01

Recently, many technical improvements in macromolecular X-ray crystallography have increased the number of structures deposited in the Protein Data Bank and improved the resolution limit of protein structures. Almost all high-resolution structures have been determined using a synchrotron radiation source in conjunction with cryocooling techniques, which are required in order to minimize radiation damage. However, optimization of cryoprotectant conditions is a time-consuming and difficult step. To overcome this problem, the high-pressure cryocooling method was developed (Kim et al., 2005) and successfully applied to many protein-structure analyses. In this report, using the high-pressure cryocooling method, the X-ray crystal structure of bovine H-protein was determined at 0.86 Å resolution. Structural comparisons between high- and ambient-pressure cryocooled crystals at ultra-high resolution illustrate the versatility of this technique. This is the first ultra-high-resolution X-ray structure obtained using the high-pressure cryocooling method.

Time-domain multiplexed high resolution fiber optics strain sensor system based on temporal response of fiber Fabry-Perot interferometers.

PubMed

Chen, Jiageng; Liu, Qingwen; He, Zuyuan

2017-09-04

We developed a multiplexed strain sensor system with high resolution using fiber Fabry-Perot interferometers (FFPI) as sensing elements. The temporal responses of the FFPIs excited by rectangular laser pulses are used to obtain the strain applied on each FFPI. The FFPIs are connected by cascaded couplers and delay fiber rolls for the time-domain multiplexing. A compact optoelectronic system performing closed-loop cyclic interrogation is employed to improve the sensing resolution and the frequency response. In the demonstration experiment, 3-channel strain sensing with resolutions better than 0.1 nε and frequency response higher than 100 Hz is realized.

Digital multi-channel high resolution phase locked loop for surveillance radar systems

NASA Astrophysics Data System (ADS)

Rizk, Mohamed; Shaaban, Shawky; Abou-El-Nadar, Usama M.; Hafez, Alaa El-Din Sayed

This paper present a multi-channel, high resolution, fast lock phase locked loop (PLL) for surveillance radar applications. Phase detector based PLLs are simple to design, suffer no systematic phase error, and can run at the highest speed. Reducing loop gain can proportionally improve jitter performance, but also reduces locking time and pull-in range. The proposed system is based on digital process and control the error signal to the voltage controlled oscillator (VCO) adaptively to control its gain in order to achieve fast lock times while improving in lock jitter performance. Under certain circumstances the design also improves the frequency agility capability of the radar system. The results show a fast lock, high resolution PLL with transient time less than 10 µ sec which is suitable to radar applications.

High Resolution Image Reconstruction from Projection of Low Resolution Images DIffering in Subpixel Shifts

NASA Technical Reports Server (NTRS)

Mareboyana, Manohar; Le Moigne-Stewart, Jacqueline; Bennett, Jerome

2016-01-01

In this paper, we demonstrate a simple algorithm that projects low resolution (LR) images differing in subpixel shifts on a high resolution (HR) also called super resolution (SR) grid. The algorithm is very effective in accuracy as well as time efficiency. A number of spatial interpolation techniques using nearest neighbor, inverse-distance weighted averages, Radial Basis Functions (RBF) etc. used in projection yield comparable results. For best accuracy of reconstructing SR image by a factor of two requires four LR images differing in four independent subpixel shifts. The algorithm has two steps: i) registration of low resolution images and (ii) shifting the low resolution images to align with reference image and projecting them on high resolution grid based on the shifts of each low resolution image using different interpolation techniques. Experiments are conducted by simulating low resolution images by subpixel shifts and subsampling of original high resolution image and the reconstructing the high resolution images from the simulated low resolution images. The results of accuracy of reconstruction are compared by using mean squared error measure between original high resolution image and reconstructed image. The algorithm was tested on remote sensing images and found to outperform previously proposed techniques such as Iterative Back Projection algorithm (IBP), Maximum Likelihood (ML), and Maximum a posterior (MAP) algorithms. The algorithm is robust and is not overly sensitive to the registration inaccuracies.

THOR Ion Mass Spectrometer (IMS)

NASA Astrophysics Data System (ADS)

Retinò, Alessandro

2017-04-01

Turbulence Heating ObserveR (THOR) is the first mission ever flown in space dedicated to plasma turbulence. The Ion Mass Spectrometer (IMS) onboard THOR will provide the first high-time resolution measurements of mass-resolved ions in near-Earth space, focusing on hot ions in the foreshock, shock and magnetosheath turbulent regions. These measurements are required to study how kinetic-scale turbulent fluctuations heat and accelerate different ion species. IMS will measure the full three-dimensional distribution functions of main ion species (H+, He++, O+) in the energy range 10 eV/q to 30 keV/q with energy resolution DE/E down to 10% and angular resolution down to 11.25˚ . The time resolution will be 150 ms for O+, 300 ms for He++ and ˜ 1s for O+, which correspond to ion scales in the the foreshock, shock and magnetosheath regions. Such high time resolution is achieved by mounting four identical IMS units phased by 90˚ in the spacecraft spin plane. Each IMS unit combines a top-hat electrostatic analyzer with deflectors at the entrance together with a time-of-flight section to perform mass selection. Adequate mass-per-charge resolution (M/q)/(ΔM/q) (≥ 8 for He++ and ≥ 3 for O+) is obtained through a 6 cm long Time-of-Flight (TOF) section. IMS electronics includes a fast sweeping high voltage board that is required to make measurements at high cadence. Ion detection includes Micro Channel Plates (MCPs) combined with Application-Specific Integrated Circuits (ASICs) for charge amplification and discrimination and a discrete Time-to-Amplitude Converter (TAC) to determine the ion time of flight. A processor board will be used to for ion events formatting and will interface with the Particle Processing Unit (PPU), which will perform data processing for THOR particle detectors. The IMS instrument is being designed and will be built and calibrated by an international consortium of scientific institutes from France, USA, Germany and Japan and Switzerland.

VISAR Analysis in the Frequency Domain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dolan, D. H.; Specht, P.

2017-05-18

VISAR measurements are typically analyzed in the time domain, where velocity is approximately proportional to fringe shift. Moving to the frequency domain clarifies the limitations of this approximation and suggests several improvements. For example, optical dispersion preserves high-frequency information, so a zero-dispersion (air delay) interferometer does not provide optimal time resolution. Combined VISAR measurements can also improve time resolution. With adequate bandwidth and reasonable noise levels, it is quite possible to achieve better resolution than the VISAR approximation allows.

High-resolution paleoenvironmental context for human occupations during the Middle Pleistocene in Europe (MIS 11, Germany)

NASA Astrophysics Data System (ADS)

Rivals, Florent; Ziegler, Reinhard

2018-05-01

High-resolution paleoecological proxies, such as stable isotopes or tooth microwear in large mammals, are often used for their potential to deliver information about the paleodietary traits of individuals and populations at the time of death. Such proxies are of interest in high resolution sites because they provide accurate data regarding the diet of large herbivores as well as the habitats that were available at the time of formation of the site, and by inference can detect seasonality in the formation of the assemblages. The integration of two techniques, tooth mesowear and microwear, applied to Middle Pleistocene assemblages of large herbivores from Steinheim and Heppenloch did not indicate seasonality at any of the two sites, most likely due to low resolution and time averaging of the dietary signal. However, the combination of the two proxies was highly informative for reconstructing the paleodiets of the large herbivores. The two paleodietary proxies provided consistent results that permitted us to propose a reconstruction of the paleodiets and habitats available at each site.

Computational Burden Resulting from Image Recognition of High Resolution Radar Sensors

PubMed Central

López-Rodríguez, Patricia; Fernández-Recio, Raúl; Bravo, Ignacio; Gardel, Alfredo; Lázaro, José L.; Rufo, Elena

2013-01-01

This paper presents a methodology for high resolution radar image generation and automatic target recognition emphasizing the computational cost involved in the process. In order to obtain focused inverse synthetic aperture radar (ISAR) images certain signal processing algorithms must be applied to the information sensed by the radar. From actual data collected by radar the stages and algorithms needed to obtain ISAR images are revised, including high resolution range profile generation, motion compensation and ISAR formation. Target recognition is achieved by comparing the generated set of actual ISAR images with a database of ISAR images generated by electromagnetic software. High resolution radar image generation and target recognition processes are burdensome and time consuming, so to determine the most suitable implementation platform the analysis of the computational complexity is of great interest. To this end and since target identification must be completed in real time, computational burden of both processes the generation and comparison with a database is explained separately. Conclusions are drawn about implementation platforms and calculation efficiency in order to reduce time consumption in a possible future implementation. PMID:23609804

Computational burden resulting from image recognition of high resolution radar sensors.

PubMed

López-Rodríguez, Patricia; Fernández-Recio, Raúl; Bravo, Ignacio; Gardel, Alfredo; Lázaro, José L; Rufo, Elena

2013-04-22

This paper presents a methodology for high resolution radar image generation and automatic target recognition emphasizing the computational cost involved in the process. In order to obtain focused inverse synthetic aperture radar (ISAR) images certain signal processing algorithms must be applied to the information sensed by the radar. From actual data collected by radar the stages and algorithms needed to obtain ISAR images are revised, including high resolution range profile generation, motion compensation and ISAR formation. Target recognition is achieved by comparing the generated set of actual ISAR images with a database of ISAR images generated by electromagnetic software. High resolution radar image generation and target recognition processes are burdensome and time consuming, so to determine the most suitable implementation platform the analysis of the computational complexity is of great interest. To this end and since target identification must be completed in real time, computational burden of both processes the generation and comparison with a database is explained separately. Conclusions are drawn about implementation platforms and calculation efficiency in order to reduce time consumption in a possible future implementation.

Study of Plasma Waves Observed onboard Rosetta in the 67P/ChuryumovGerasimenko Comet Environment Using High Time Resolution Density Data Inferred from RPC-MIP and RPC-LAP Cross-calibration

NASA Astrophysics Data System (ADS)

Breuillard, H.; Henri, P.; Vallières, X.; Eriksson, A. I.; Odelstad, E.; Johansson, F. L.; Richter, I.; Goetz, C.; Wattieaux, G.; Tsurutani, B.; Hajra, R.; Le Contel, O.

2017-12-01

During two years, the groundbreaking ESA/Rosetta mission was able to escort comet 67P where previous cometary missions were only limited to flybys. This enabled for the first time to make in-situ measurements of the evolution of a comet's plasma environment. The density and temperature measured by Rosetta are derived from RPC-Mutual Impedance Probe (MIP) and RPC-Langmuir Probe (LAP). On one hand, low time resolution electron density are calculated using the plasma frequency extracted from the MIP mutual impedance spectra. On the other hand, high time resolution density fluctuations are estimated from the spacecraft potential measured by LAP. In this study, using a simple spacecraft charging model, we perform a cross-calibration of MIP plasma density and LAP spacecraft potential variations to obtain high time resolution measurements of the electron density. These results are also used to constrain the electron temperature. Then we make use of these new dataset, together with RPC-MAG magnetic field measurements, to investigate for the first time the compressibility and the correlations between plasma and magnetic field variations, for both singing comet waves and steepened waves observed, respectively during low and high cometary outgassing activity, in the plasma environment of comet 67P.

Timing Characterization of Helium-4 Fast Neutron Detector with EJ-309 Organic Liquid Scintillator

NASA Astrophysics Data System (ADS)

Liang, Yinong; Zhu, Ting; Enqvist, Andreas

2018-01-01

Recently, the Helium-4 gas fast neutron scintillation detectors is being used in time-sensitive measurements, such time-of-flight and multiplicity counting. In this paper, a set of time aligned signals was acquired in a coincidence measurement using the Helium-4 gas detectors and EJ-309 liquid scintillators. The high-speed digitizer system is implanted with a trigger moving average window (MAW) unit combing with its constant fraction discriminator (CFD) feature. It can calculate a "time offset" to the timestamp value to get a higher resolution timestamp (up to 50 ps), which is better than the digitizer's time resolution (4 ns) [1]. The digitized waveforms were saved to the computer hard drive and post processed with digital analysis code to determine the difference of their arrival times. The full-width at half-maximum (FWHM) of the Gaussian fit was used as to examine the resolution. For the cascade decay of Cobalt-60 (1.17 and 1.33 MeV), the first version of the Helium-4 detector with two Hamamatsu R580 photomultipliers (PMT) installed at either end of the cylindrical gas chamber (20 cm in length and 4.4 cm in diameter) has a time resolution which is about 3.139 ns FWHM. With improved knowledge of the timing performance, the Helium-4 scintillation detectors are excellent for neutron energy spectrometry applications requiring high temporal and energy resolutions.

A new omni-directional multi-camera system for high resolution surveillance

NASA Astrophysics Data System (ADS)

Cogal, Omer; Akin, Abdulkadir; Seyid, Kerem; Popovic, Vladan; Schmid, Alexandre; Ott, Beat; Wellig, Peter; Leblebici, Yusuf

2014-05-01

Omni-directional high resolution surveillance has a wide application range in defense and security fields. Early systems used for this purpose are based on parabolic mirror or fisheye lens where distortion due to the nature of the optical elements cannot be avoided. Moreover, in such systems, the image resolution is limited to a single image sensor's image resolution. Recently, the Panoptic camera approach that mimics the eyes of flying insects using multiple imagers has been presented. This approach features a novel solution for constructing a spherically arranged wide FOV plenoptic imaging system where the omni-directional image quality is limited by low-end sensors. In this paper, an overview of current Panoptic camera designs is provided. New results for a very-high resolution visible spectrum imaging and recording system inspired from the Panoptic approach are presented. The GigaEye-1 system, with 44 single cameras and 22 FPGAs, is capable of recording omni-directional video in a 360°×100° FOV at 9.5 fps with a resolution over (17,700×4,650) pixels (82.3MP). Real-time video capturing capability is also verified at 30 fps for a resolution over (9,000×2,400) pixels (21.6MP). The next generation system with significantly higher resolution and real-time processing capacity, called GigaEye-2, is currently under development. The important capacity of GigaEye-1 opens the door to various post-processing techniques in surveillance domain such as large perimeter object tracking, very-high resolution depth map estimation and high dynamicrange imaging which are beyond standard stitching and panorama generation methods.

Long Time-lapse Nanoscopy with Spontaneously Blinking Membrane Probes

PubMed Central

Takakura, Hideo; Zhang, Yongdeng; Erdmann, Roman S.; Thompson, Alexander D.; Lin, Yu; McNellis, Brian; Rivera-Molina, Felix; Uno, Shin-nosuke; Kamiya, Mako; Urano, Yasuteru; Rothman, James E.; Bewersdorf, Joerg; Schepartz, Alanna; Toomre, Derek

2017-01-01

Long time-lapse, diffraction-unlimited super-resolution imaging of cellular structures and organelles in living cells is highly challenging, as it requires dense labeling, bright, highly photostable dyes, and non-toxic conditions. We developed a set of high-density, environment-sensitive (HIDE) membrane probes based on HMSiR that assemble in situ and enable long time-lapse, live cell nanoscopy of discrete cellular structures and organelles with high spatio-temporal resolution. HIDE-enabled nanoscopy movies are up to 50x longer than movies obtained with labeled proteins, reveal the 2D dynamics of the mitochondria, plasma membrane, and filopodia, and the 2D and 3D dynamics of the endoplasmic reticulum in living cells. These new HIDE probes also facilitate the acquisition of live cell, two-color, super-resolution images, greatly expanding the utility of nanoscopy to visualize processes and structures in living cells. PMID:28671662

Super-Resolution of Plant Disease Images for the Acceleration of Image-based Phenotyping and Vigor Diagnosis in Agriculture.

PubMed

Yamamoto, Kyosuke; Togami, Takashi; Yamaguchi, Norio

2017-11-06

Unmanned aerial vehicles (UAVs or drones) are a very promising branch of technology, and they have been utilized in agriculture-in cooperation with image processing technologies-for phenotyping and vigor diagnosis. One of the problems in the utilization of UAVs for agricultural purposes is the limitation in flight time. It is necessary to fly at a high altitude to capture the maximum number of plants in the limited time available, but this reduces the spatial resolution of the captured images. In this study, we applied a super-resolution method to the low-resolution images of tomato diseases to recover detailed appearances, such as lesions on plant organs. We also conducted disease classification using high-resolution, low-resolution, and super-resolution images to evaluate the effectiveness of super-resolution methods in disease classification. Our results indicated that the super-resolution method outperformed conventional image scaling methods in spatial resolution enhancement of tomato disease images. The results of disease classification showed that the accuracy attained was also better by a large margin with super-resolution images than with low-resolution images. These results indicated that our approach not only recovered the information lost in low-resolution images, but also exerted a beneficial influence on further image analysis. The proposed approach will accelerate image-based phenotyping and vigor diagnosis in the field, because it not only saves time to capture images of a crop in a cultivation field but also secures the accuracy of these images for further analysis.

Super-Resolution of Plant Disease Images for the Acceleration of Image-based Phenotyping and Vigor Diagnosis in Agriculture

PubMed Central

Togami, Takashi; Yamaguchi, Norio

2017-01-01

Unmanned aerial vehicles (UAVs or drones) are a very promising branch of technology, and they have been utilized in agriculture—in cooperation with image processing technologies—for phenotyping and vigor diagnosis. One of the problems in the utilization of UAVs for agricultural purposes is the limitation in flight time. It is necessary to fly at a high altitude to capture the maximum number of plants in the limited time available, but this reduces the spatial resolution of the captured images. In this study, we applied a super-resolution method to the low-resolution images of tomato diseases to recover detailed appearances, such as lesions on plant organs. We also conducted disease classification using high-resolution, low-resolution, and super-resolution images to evaluate the effectiveness of super-resolution methods in disease classification. Our results indicated that the super-resolution method outperformed conventional image scaling methods in spatial resolution enhancement of tomato disease images. The results of disease classification showed that the accuracy attained was also better by a large margin with super-resolution images than with low-resolution images. These results indicated that our approach not only recovered the information lost in low-resolution images, but also exerted a beneficial influence on further image analysis. The proposed approach will accelerate image-based phenotyping and vigor diagnosis in the field, because it not only saves time to capture images of a crop in a cultivation field but also secures the accuracy of these images for further analysis. PMID:29113104

Culturing of avian embryos for time-lapse imaging.

PubMed

Rupp, Paul A; Rongish, Brenda J; Czirok, Andras; Little, Charles D

2003-02-01

Monitoring morphogenetic processes, at high resolution over time, has been a long-standing goal of many developmental cell biologists. It is critical to image cells in their natural environment whenever possible; however, imaging many warm-blooded vertebrates, especially mammals, is problematic. At early stages of development, birds are ideal for imaging, since the avian body plan is very similar to that of mammals. We have devised a culturing technique that allows for the acquisition of high-resolution differential interference contrast and epifluorescence images of developing avian embryos in a 4-D (3-D + time) system. The resulting information, from intact embryos, is derived from an area encompassing several millimeters, at micrometer resolution for up to 30 h.

A Dedicated Micro-Tomography Beamline For The Australian Synchrotron

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mayo, Sheridan C.; Stevenson, Andrew W.; Wilkins, Stephen W.

2010-07-23

A dedicated micro-tomography beamline is proposed for the Australian Synchrotron. It will enable high-resolution micro-tomography with resolution below a micron and supporting phase-contrast imaging modes. A key feature of the beamline will be high-throughput/high-speed operation enabling near real-time micro-tomography.

HESS Opinions: The need for process-based evaluation of large-domain hyper-resolution models

NASA Astrophysics Data System (ADS)

Melsen, Lieke A.; Teuling, Adriaan J.; Torfs, Paul J. J. F.; Uijlenhoet, Remko; Mizukami, Naoki; Clark, Martyn P.

2016-03-01

A meta-analysis on 192 peer-reviewed articles reporting on applications of the variable infiltration capacity (VIC) model in a distributed way reveals that the spatial resolution at which the model is applied has increased over the years, while the calibration and validation time interval has remained unchanged. We argue that the calibration and validation time interval should keep pace with the increase in spatial resolution in order to resolve the processes that are relevant at the applied spatial resolution. We identified six time concepts in hydrological models, which all impact the model results and conclusions. Process-based model evaluation is particularly relevant when models are applied at hyper-resolution, where stakeholders expect credible results both at a high spatial and temporal resolution.

HESS Opinions: The need for process-based evaluation of large-domain hyper-resolution models

NASA Astrophysics Data System (ADS)

Melsen, L. A.; Teuling, A. J.; Torfs, P. J. J. F.; Uijlenhoet, R.; Mizukami, N.; Clark, M. P.

2015-12-01

A meta-analysis on 192 peer-reviewed articles reporting applications of the Variable Infiltration Capacity (VIC) model in a distributed way reveals that the spatial resolution at which the model is applied has increased over the years, while the calibration and validation time interval has remained unchanged. We argue that the calibration and validation time interval should keep pace with the increase in spatial resolution in order to resolve the processes that are relevant at the applied spatial resolution. We identified six time concepts in hydrological models, which all impact the model results and conclusions. Process-based model evaluation is particularly relevant when models are applied at hyper-resolution, where stakeholders expect credible results both at a high spatial and temporal resolution.

Toward seamless high-resolution flash flood forecasting over Europe based on radar nowcasting and NWP: An evaluation with case studies

NASA Astrophysics Data System (ADS)

Park, Shinju; Berenguer, Marc; Sempere-Torres, Daniel; Baugh, Calum; Smith, Paul

2017-04-01

Flash floods induced by heavy rain are one of the hazardous natural events that significantly affect human lives. Because flash floods are characterized by their rapid onset, forecasting flash flood to lead an effective response requires accurate rainfall predictions with high spatial and temporal resolution and adequate representation of the hydrologic and hydraulic processes within a catchment that determine rainfall-runoff accumulations. We present extreme flash flood cases which occurred throughout Europe in 2015-2016 that were identified and forecasted by two real-time approaches: 1) the European Rainfall-Induced Hazard Assessment System (ERICHA) and 2) the European Runoff Index based on Climatology (ERIC). ERICHA is based on the nowcasts of accumulated precipitation generated from the pan-European radar composites produced by the EUMETNET project OPERA. It has the advantage of high-resolution precipitation inputs and rapidly updated forecasts (every 15 minutes), but limited forecast lead time (up to 8 hours). ERIC, on the other hand, provides 5-day forecasts based on the COSMO-LEPS NWP simulations updated 2 times a day but is only produced at a 7 km resolution. We compare the products from both systems and focus on showing the advantages, limitations and complementarities of ERICHA and ERIC for seamless high-resolution flash flood forecasting.

Molecular simultaneous detection of Cherry necrotic rusty mottle virus and Cherry green ring mottle virus by real-time RT-PCR and high resolution melting analysis

USDA-ARS?s Scientific Manuscript database

In this study, real-time RT-PCR assays were combined with high resolution melting (HRM) analysis for the simultaneous detection of Cherry necrotic rusty mottle virus (CNRMV) and Cherry green ring mottle virus (CGRMV) infection in sweet cherry trees. Detection of CNRMV and CGRMV was performed using a...

Evaluation of real-time high-resolution MM5 predictions over the Great Lakes region

Treesearch

Shiyuan Zhong; Hee-Jin In; Xindi Bian; Joseph Charney; Warren Heilman; Brian Potter

2005-01-01

Real-time high-resolution mesoscale predictions using the fifth-generation Pennsylvania State University–NCAR Mesoscale Model (MM5) over the Great Lakes region are evaluated for the 2002/03 winter and 2003 summer seasons using surface and upper-air observations, with a focus on near-surface and boundary layer properties that are important for applications such as air...

Rapid high-resolution four-dimensional NMR spectroscopy using the filter diagonalization method and its advantages for detailed structural elucidation of oligosaccharides.

PubMed

Armstrong, Geoffrey S; Mandelshtam, Vladimir A; Shaka, A J; Bendiak, Brad

2005-03-01

Four-dimensional nuclear magnetic resonance spectroscopy with high resolution of signals in the indirect dimensions is reported as an implementation of the filter diagonalization method (FDM). Using an oligosaccharide derivatized with 13C-labeled acetyl isotags, a four-dimensional constant-time pulse sequence was tailored for conjoint use with the FDM. Results demonstrate that high resolution in all dimensions can be achieved using a relatively short experimental time period (19 h), even though the spectrum is highly congested in the direct and all three indirect dimensions. The combined use of isotags, constant-time pulse sequences, and FDM permits rapid isolation of sugar ring proton spin systems in multiple dimensions and enables all endocyclic J-couplings to be simply measured, the key goal to assigning sugar stereochemistry and anomeric configuration. A general method for rapid, unambiguous elucidation of spin systems in oligosaccharides has been a long-sought goal of carbohydrate NMR, and isotags combined with the FDM now enable this to be easily performed. Additional general advantages of the FDM program for generating high-resolution 2D slices in any dimension from a 4D spectrum are emphasized.

Coastal and Inland Water Applications of High Resolution Optical Satellite Data from Landsat-8 and Sentinel-2

NASA Astrophysics Data System (ADS)

Vanhellemont, Q.

2016-02-01

Since the launch of Landsat-8 (L8) in 2013, a joint NASA/USGS programme, new applications of high resolution imagery for coastal and inland waters have become apparent. The optical imaging instrument on L8, the Operational Land Imager (OLI), is much improved compared to its predecessors on L5 and L7, especially with regards to SNR and digitization, and is therefore well suited for retrieving water reflectances and derived parameters such as turbidity and suspended sediment concentration. In June 2015, the European Space Agency (ESA) successfully launched a similar instrument, the MultiSpectral Imager (MSI), on board of Sentinel-2A (S2A). Imagery from both L8 and S2A are free of charge and publicly available (S2A starting at the end of 2015). Atmospheric correction schemes and processing software is under development in the EC-FP7 HIGHROC project. The spatial resolution of these instruments (10-60 m) is a great improvement over typical moderate resolution ocean colour sensors such as MODIS and MERIS (0.25 - 1 km). At higher resolution, many more lakes, rivers, ports and estuaries are spatially resolved, and can thus now be studied using satellite data, unlocking potential for mandatory monitoring e.g. under European Directives such as the Marine Strategy Framework Directive and the Water Framework Directive. We present new applications of these high resolution data, such as monitoring of offshore constructions, wind farms, sediment transport, dredging and dumping, shipping and fishing activities. The spatial variability at sub moderate resolution (0.25 - 1 km) scales can be assessed, as well as the impact of sub grid scale variability (including ships and platforms used for validation) on the moderate pixel retrieval. While the daily revisit time of the moderate resolution sensors is vastly superior to those of the high resolution satellites, at the equator respectively 16 and 10 days for L8 and S2A, the low revisit times can be partially mitigated by combining data streams. Time-series of L8 and S2A imagery are presented to show the power of combining the two satellite missions. With the launch of Sentinel-2B (expected mid-2016), the time-series will be extended with another high resolution sensor. S2B will be on the same orbit as S2A, spaced 180 degrees apart, bringing the S2A+B combined revisit time down to 5 days.

A High Space-Time Resolution Dataset Linking Meteorological Forcing and Hydro-Sedimentary Response in a Mesoscale Mediterranean Catchment (Auzon) of the Ardèche Region, France

NASA Astrophysics Data System (ADS)

Nord, G.; Braud, I.; Boudevillain, B.; Gérard, S.; Molinié, G.; Vandervaere, J. P.; Huza, J.; Le Coz, J.; Dramais, G.; Legout, C.; Berne, A.; Grazioli, J.; Raupach, T.; Van Baelen, J.; Wijbrans, A.; Delrieu, G.; Andrieu, J.; Caliano, M.; Aubert, C.; Teuling, R.; Le Boursicaud, R.; Branger, F.; Vincendon, B.; Horner, I.

2014-12-01

A comprehensive hydrometeorological dataset is presented spanning the period 1 Jan 2011-31 Dec 2014 to improve the understanding and simulation of the hydrological processes leading to flash floods in a mesoscale catchment (Auzon, 116 km2) of the Mediterranean region. The specificity of the dataset is its high space-time resolution, especially concerning rainfall and the hydrological response which is particularly adapted to the highly spatially variable rainfall events that may occur in this region. This type of dataset is rare in scientific literature because of the quantity and type of sensors for meteorology and surface hydrology. Rainfall data include continuous precipitation measured by rain-gages (5 min time step for the research network of 21 rain-gages and 1h time step for the operational network of 9 rain-gages), S-band Doppler dual-polarization radar (1 km2, 5 min resolution), and disdrometers (11 sensors working at 1 min time step). During the special observation period (SOP-1) and enhanced observation period (Sep-Dec 2012, Sep-Dec 2013) of the HyMeX (Hydrological Cycle in the Mediterranean Experiment) project, two X-band radars provided precipitation measurements at very fine spatial and temporal scales (1 ha, 5 min). Meteorological data are taken from the operational surface weather observation stations of Meteo France at the hourly time resolution (6 stations in the region of interest). The monitoring of surface hydrology and suspended sediment is multi-scale and based on nested catchments. Three hydrometric stations measure water discharge and additional physico-chemical variables at a 2-10 min time resolution. Two experimental plots monitor overland flow and erosion at 1 min time resolution on a hillslope with vineyard. A network of 11 gauges continuously measures water level and temperature in headwater subcatchments at a time resolution of 2-5 min. A network of soil moisture sensors enable the continuous measurement of soil volumetric water content at 20 min time resolution at 9 sites. Additionally, opportunistic observations (soil moisture measurements and stream gauging) were performed during floods between 2012 and 2014. The data are appropriate for understanding rainfall variability, improving areal rainfall estimations and progress in distributed hydrological modelling.

A High Space-Time Resolution Dataset Linking Meteorological Forcing and Hydro-Sedimentary Response in a Mesoscale Mediterranean Catchment (Auzon) of the Ardèche Region, France

NASA Astrophysics Data System (ADS)

Nord, G.; Braud, I.; Boudevillain, B.; Gérard, S.; Molinié, G.; Vandervaere, J. P.; Huza, J.; Le Coz, J.; Dramais, G.; Legout, C.; Berne, A.; Grazioli, J.; Raupach, T.; Van Baelen, J.; Wijbrans, A.; Delrieu, G.; Andrieu, J.; Caliano, M.; Aubert, C.; Teuling, R.; Le Boursicaud, R.; Branger, F.; Vincendon, B.; Horner, I.

2015-12-01

A comprehensive hydrometeorological dataset is presented spanning the period 1 Jan 2011-31 Dec 2014 to improve the understanding and simulation of the hydrological processes leading to flash floods in a mesoscale catchment (Auzon, 116 km2) of the Mediterranean region. The specificity of the dataset is its high space-time resolution, especially concerning rainfall and the hydrological response which is particularly adapted to the highly spatially variable rainfall events that may occur in this region. This type of dataset is rare in scientific literature because of the quantity and type of sensors for meteorology and surface hydrology. Rainfall data include continuous precipitation measured by rain-gages (5 min time step for the research network of 21 rain-gages and 1h time step for the operational network of 9 rain-gages), S-band Doppler dual-polarization radar (1 km2, 5 min resolution), and disdrometers (11 sensors working at 1 min time step). During the special observation period (SOP-1) and enhanced observation period (Sep-Dec 2012, Sep-Dec 2013) of the HyMeX (Hydrological Cycle in the Mediterranean Experiment) project, two X-band radars provided precipitation measurements at very fine spatial and temporal scales (1 ha, 5 min). Meteorological data are taken from the operational surface weather observation stations of Meteo France at the hourly time resolution (6 stations in the region of interest). The monitoring of surface hydrology and suspended sediment is multi-scale and based on nested catchments. Three hydrometric stations measure water discharge and additional physico-chemical variables at a 2-10 min time resolution. Two experimental plots monitor overland flow and erosion at 1 min time resolution on a hillslope with vineyard. A network of 11 gauges continuously measures water level and temperature in headwater subcatchments at a time resolution of 2-5 min. A network of soil moisture sensors enable the continuous measurement of soil volumetric water content at 20 min time resolution at 9 sites. Additionally, opportunistic observations (soil moisture measurements and stream gauging) were performed during floods between 2012 and 2014. The data are appropriate for understanding rainfall variability, improving areal rainfall estimations and progress in distributed hydrological modelling.

Microdome-gooved Gd(2)O(2)S:Tb scintillator for flexible and high resolution digital radiography.

PubMed

Jung, Phill Gu; Lee, Chi Hoon; Bae, Kong Myeong; Lee, Jae Min; Lee, Sang Min; Lim, Chang Hwy; Yun, Seungman; Kim, Ho Kyung; Ko, Jong Soo

2010-07-05

A flexible microdome-grooved Gd(2)O(2)S:Tb scintillator is simulated, fabricated, and characterized for digital radiography applications. According to Monte Carlo simulation results, the dome-grooved structure has a high spatial resolution, which is verified by X-ray image performance of the scintillator. The proposed scintillator has lower X-ray sensitivity than a nonstructured scintillator but almost two times higher spatial resolution at high spatial frequency. Through evaluation of the X-ray performance of the fabricated scintillators, we confirm that the microdome-grooved scintillator can be applied to next-generation flexible digital radiography systems requiring high spatial resolution.

Length-extension resonator as a force sensor for high-resolution frequency-modulation atomic force microscopy in air.

PubMed

Beyer, Hannes; Wagner, Tino; Stemmer, Andreas

2016-01-01

Frequency-modulation atomic force microscopy has turned into a well-established method to obtain atomic resolution on flat surfaces, but is often limited to ultra-high vacuum conditions and cryogenic temperatures. Measurements under ambient conditions are influenced by variations of the dew point and thin water layers present on practically every surface, complicating stable imaging with high resolution. We demonstrate high-resolution imaging in air using a length-extension resonator operating at small amplitudes. An additional slow feedback compensates for changes in the free resonance frequency, allowing stable imaging over a long period of time with changing environmental conditions.

Assessment of prediction skill in equatorial Pacific Ocean in high resolution model of CFS

NASA Astrophysics Data System (ADS)

Arora, Anika; Rao, Suryachandra A.; Pillai, Prasanth; Dhakate, Ashish; Salunke, Kiran; Srivastava, Ankur

2018-01-01

The effect of increasing atmospheric resolution on prediction skill of El Niño southern oscillation phenomenon in climate forecast system model is explored in this paper. Improvement in prediction skill for sea surface temperature (SST) and winds at all leads compared to low resolution model in the tropical Indo-Pacific basin is observed. High resolution model is able to capture extreme events reasonably well. As a result, the signal to noise ratio is improved in the high resolution model. However, spring predictability barrier (SPB) for summer months in Nino 3 and Nino 3.4 region is stronger in high resolution model, in spite of improvement in overall prediction skill and dynamics everywhere else. Anomaly correlation coefficient of SST in high resolution model with observations in Nino 3.4 region targeting boreal summer months when predicted at lead times of 3-8 months in advance decreased compared its lower resolution counterpart. It is noted that higher variance of winds predicted in spring season over central equatorial Pacific compared to observed variance of winds results in stronger than normal response on subsurface ocean, hence increases SPB for boreal summer months in high resolution model.

Portable, Battery Operated Capillary Electrophoresis with Optical Isomer Resolution Integrated with Ionization Source for Mass Spectrometry

NASA Astrophysics Data System (ADS)

Moini, Mehdi; Rollman, Christopher M.

2016-03-01

We introduce a battery operated capillary electrophoresis electrospray ionization (CE/ESI) source for mass spectrometry with optical isomer separation capability. The source fits in front of low or high resolution mass spectrometers similar to a nanospray source with about the same weight and size. The source has two high voltage power supplies (±25 kV HVPS) capable of operating in forward or reverse polarity modes and powered by a 12 V rechargeable lithium ion battery with operation time of ~10 h. In ultrafast CE mode, in which short narrow capillaries (≤15 μm i.d., 15-25 cm long) and field gradients ≥1000 V/cm are used, peak widths at the base are <1 s wide. Under these conditions, the source provides high resolution separation, including optical isomer resolution in ~1 min. Using a low resolution mass spectrometer (LTQ Velos) with a scan time of 0.07 s/scan, baseline separation of amino acids and their optical isomers were achieved in ~1 min. Moreover, bovine serum albumin (BSA) was analyzed in ~1 min with 56% coverage using the data-dependent MS/MS. Using a high resolution mass spectrometer (Thermo Orbitrap Elite) with 15,000 resolution, the fastest scan time achieved was 0.15 s, which was adequate for CE-MS analysis when optical isomer separation is not required or when the optical isomers were well separated. Figures of merit including a detection limit of 2 fmol and linear dynamic range of two orders of magnitude were achieved for amino acids.

Transit time spreads in biased paracentric hemispherical deflection analyzers

NASA Astrophysics Data System (ADS)

Sise, Omer; Zouros, Theo J. M.

2016-02-01

The biased paracentric hemispherical deflection analyzers (HDAs) are an alternative to conventional (centric) HDAs maintaining greater dispersion, lower angular aberrations, and hence better energy resolution without the use of any additional fringing field correctors. In the present work, the transit time spread of the biased paracentric HDA is computed over a wide range of analyzer parameters. The combination of high energy resolution with good time resolution and simplicity of design makes the biased paracentric analyzers very promising for both coincidence and singles spectroscopy applications.

Satellite image fusion based on principal component analysis and high-pass filtering.

PubMed

Metwalli, Mohamed R; Nasr, Ayman H; Allah, Osama S Farag; El-Rabaie, S; Abd El-Samie, Fathi E

2010-06-01

This paper presents an integrated method for the fusion of satellite images. Several commercial earth observation satellites carry dual-resolution sensors, which provide high spatial resolution or simply high-resolution (HR) panchromatic (pan) images and low-resolution (LR) multi-spectral (MS) images. Image fusion methods are therefore required to integrate a high-spectral-resolution MS image with a high-spatial-resolution pan image to produce a pan-sharpened image with high spectral and spatial resolutions. Some image fusion methods such as the intensity, hue, and saturation (IHS) method, the principal component analysis (PCA) method, and the Brovey transform (BT) method provide HR MS images, but with low spectral quality. Another family of image fusion methods, such as the high-pass-filtering (HPF) method, operates on the basis of the injection of high frequency components from the HR pan image into the MS image. This family of methods provides less spectral distortion. In this paper, we propose the integration of the PCA method and the HPF method to provide a pan-sharpened MS image with superior spatial resolution and less spectral distortion. The experimental results show that the proposed fusion method retains the spectral characteristics of the MS image and, at the same time, improves the spatial resolution of the pan-sharpened image.

Reconstruction of full high-resolution HSQC using signal split in aliased spectra.

PubMed

Foroozandeh, Mohammadali; Jeannerat, Damien

2015-11-01

Resolution enhancement is a long-sought goal in NMR spectroscopy. In conventional multidimensional NMR experiments, such as the (1) H-(13) C HSQC, the resolution in the indirect dimensions is typically 100 times lower as in 1D spectra because it is limited by the experimental time. Reducing the spectral window can significantly increase the resolution but at the cost of ambiguities in frequencies as a result of spectral aliasing. Fortunately, this information is not completely lost and can be retrieved using methods in which chemical shifts are encoded in the aliased spectra and decoded after processing to reconstruct high-resolution (1) H-(13) C HSQC spectrum with full spectral width and a resolution similar to that of 1D spectra. We applied a new reconstruction method, RHUMBA (reconstruction of high-resolution using multiplet built on aliased spectra), to spectra obtained from the differential evolution for non-ambiguous aliasing-HSQC and the new AMNA (additional modulation for non-ambiguous aliasing)-HSQC experiments. The reconstructed spectra significantly facilitate both manual and automated spectral analyses and structure elucidation based on heteronuclear 2D experiments. The resolution is enhanced by two orders of magnitudes without the usual complications due to spectral aliasing. Copyright © 2015 John Wiley & Sons, Ltd.

In vivo High Angular Resolution Diffusion-Weighted Imaging of Mouse Brain at 16.4 Tesla

PubMed Central

Alomair, Othman I.; Brereton, Ian M.; Smith, Maree T.; Galloway, Graham J.; Kurniawan, Nyoman D.

2015-01-01

Magnetic Resonance Imaging (MRI) of the rodent brain at ultra-high magnetic fields (> 9.4 Tesla) offers a higher signal-to-noise ratio that can be exploited to reduce image acquisition time or provide higher spatial resolution. However, significant challenges are presented due to a combination of longer T 1 and shorter T 2/T2* relaxation times and increased sensitivity to magnetic susceptibility resulting in severe local-field inhomogeneity artefacts from air pockets and bone/brain interfaces. The Stejskal-Tanner spin echo diffusion-weighted imaging (DWI) sequence is often used in high-field rodent brain MRI due to its immunity to these artefacts. To accurately determine diffusion-tensor or fibre-orientation distribution, high angular resolution diffusion imaging (HARDI) with strong diffusion weighting (b >3000 s/mm2) and at least 30 diffusion-encoding directions are required. However, this results in long image acquisition times unsuitable for live animal imaging. In this study, we describe the optimization of HARDI acquisition parameters at 16.4T using a Stejskal-Tanner sequence with echo-planar imaging (EPI) readout. EPI segmentation and partial Fourier encoding acceleration were applied to reduce the echo time (TE), thereby minimizing signal decay and distortion artefacts while maintaining a reasonably short acquisition time. The final HARDI acquisition protocol was achieved with the following parameters: 4 shot EPI, b = 3000 s/mm2, 64 diffusion-encoding directions, 125×150 μm2 in-plane resolution, 0.6 mm slice thickness, and 2h acquisition time. This protocol was used to image a cohort of adult C57BL/6 male mice, whereby the quality of the acquired data was assessed and diffusion tensor imaging (DTI) derived parameters were measured. High-quality images with high spatial and angular resolution, low distortion and low variability in DTI-derived parameters were obtained, indicating that EPI-DWI is feasible at 16.4T to study animal models of white matter (WM) diseases. PMID:26110770

Time series evapotranspiration maps at a regional scale: A methodology, evaluation, and their use in water resources management

NASA Astrophysics Data System (ADS)

Gowda, P. H.

2016-12-01

Evapotranspiration (ET) is an important process in ecosystems' water budget and closely linked to its productivity. Therefore, regional scale daily time series ET maps developed at high and medium resolutions have large utility in studying the carbon-energy-water nexus and managing water resources. There are efforts to develop such datasets on a regional to global scale but often faced with the limitations of spatial-temporal resolution tradeoffs in satellite remote sensing technology. In this study, we developed frameworks for generating high and medium resolution daily ET maps from Landsat and MODIS (Moderate Resolution Imaging Spectroradiometer) data, respectively. For developing high resolution (30-m) daily time series ET maps with Landsat TM data, the series version of Two Source Energy Balance (TSEB) model was used to compute sensible and latent heat fluxes of soil and canopy separately. Landsat 5 (2000-2011) and Landsat 8 (2013-2014) imageries for row 28/35 and 27/36 covering central Oklahoma was used. MODIS data (2001-2014) covering Oklahoma and Texas Panhandle was used to develop medium resolution (250-m), time series daily ET maps with SEBS (Surface Energy Balance System) model. An extensive network of weather stations managed by Texas High Plains ET Network and Oklahoma Mesonet was used to generate spatially interpolated inputs of air temperature, relative humidity, wind speed, solar radiation, pressure, and reference ET. A linear interpolation sub-model was used to estimate the daily ET between the image acquisition days. Accuracy assessment of daily ET maps were done against eddy covariance data from two grassland sites at El Reno, OK. Statistical results indicated good performance by modeling frameworks developed for deriving time series ET maps. Results indicated that the proposed ET mapping framework is suitable for deriving daily time series ET maps at regional scale with Landsat and MODIS data.

Ultra-high resolution coded wavefront sensor.

PubMed

Wang, Congli; Dun, Xiong; Fu, Qiang; Heidrich, Wolfgang

2017-06-12

Wavefront sensors and more general phase retrieval methods have recently attracted a lot of attention in a host of application domains, ranging from astronomy to scientific imaging and microscopy. In this paper, we introduce a new class of sensor, the Coded Wavefront Sensor, which provides high spatio-temporal resolution using a simple masked sensor under white light illumination. Specifically, we demonstrate megapixel spatial resolution and phase accuracy better than 0.1 wavelengths at reconstruction rates of 50 Hz or more, thus opening up many new applications from high-resolution adaptive optics to real-time phase retrieval in microscopy.

Spatial resolution limitation of liquid crystal spatial light modulator

NASA Astrophysics Data System (ADS)

Wang, Xinghua; Wang, Bin; McManamon, Paul F., III; Pouch, John J.; Miranda, Felix A.; Anderson, James E.; Bos, Philip J.

2004-10-01

The effect of fringing electric fields in a liquid crystal (LC) Optical Phased Array (OPA), also referred to as a spatial light modulator (SLM), is a governing factor that determines the diffraction efficiency (DE) of the LC OPA for high resolution spatial phase modulation. In this article, the fringing field effect in a high resolution LC OPA is studied by accurate modeling the DE of the LC blazed gratings by LC director simulation and Finite Difference Time Domain (FDTD) simulation. Influence factors that contribute significantly to the DE are discussed. Such results provide fundamental understanding for high resolution LC devices.

A multi-purpose readout electronics for CdTe and CZT detectors for x-ray imaging applications

NASA Astrophysics Data System (ADS)

Yue, X. B.; Deng, Z.; Xing, Y. X.; Liu, Y. N.

2017-09-01

A multi-purpose readout electronics based on the DPLMS digital filter has been developed for CdTe and CZT detectors for X-ray imaging applications. Different filter coefficients can be synthesized optimized either for high energy resolution at relatively low counting rate or for high rate photon-counting with reduced energy resolution. The effects of signal width constraints, sampling rate and length were numerical studied by Mento Carlo simulation with simple CRRC shaper input signals. The signal width constraint had minor effect and the ENC was only increased by 6.5% when the signal width was shortened down to 2 τc. The sampling rate and length depended on the characteristic time constants of both input and output signals. For simple CR-RC input signals, the minimum number of the filter coefficients was 12 with 10% increase in ENC when the output time constant was close to the input shaping time. A prototype readout electronics was developed for demonstration, using a previously designed analog front ASIC and a commercial ADC card. Two different DPLMS filters were successfully synthesized and applied for high resolution and high counting rate applications respectively. The readout electronics was also tested with a linear array CdTe detector. The energy resolutions of Am-241 59.5 keV peak were measured to be 6.41% in FWHM for the high resolution filter and to be 13.58% in FWHM for the high counting rate filter with 160 ns signal width constraint.

Detection of grapes in natural environment using HOG features in low resolution images

NASA Astrophysics Data System (ADS)

Škrabánek, Pavel; Majerík, Filip

2017-07-01

Detection of grapes in real-life images has importance in various viticulture applications. A grape detector based on an SVM classifier, in combination with a HOG descriptor, has proven to be very efficient in detection of white varieties in high-resolution images. Nevertheless, the high time complexity of such utilization was not suitable for its real-time applications, even when a detector of a simplified structure was used. Thus, we examined possibilities of the simplified version application on images of lower resolutions. For this purpose, we designed a method aimed at search for a detector’s setting which gives the best time complexity vs. performance ratio. In order to provide precise evaluation results, we formed new extended datasets. We discovered that even applied on low-resolution images, the simplified detector, with an appropriate setting of all tuneable parameters, was competitive with other state of the art solutions. We concluded that the detector is qualified for real-time detection of grapes in real-life images.

Final Report: High Spectral Resolution Atmospheric Emitted Radiance Studies with the ARM UAV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Revercomb, Henry E.

1999-12-31

The active participation in the Atmospheric Radiation Measurement (ARM) Unmanned Airborne Vehicle (UAV) science team that was anticipated in the grant proposal was indefinitely delayed after the first year due to a programmatic decision to exclude the high spectral resolution observations from the existing ARM UAV program. However, this report shows that substantial progress toward the science objectives of this grant have made with the help of separate funding from NASA and other agencies. In the four year grant period (including time extensions), a new high spectral resolution instrument has been flown and has successfully demonstrated the ability to obtainmore » measurements of the type needed in the conduct of this grant. In the near term, the third water vapor intensive observing period (WVIOP-3) in October 2000 will provide an opportunity to bring the high spectral resolution observations of upwelling radiance into the ARM program to complement the downwelling radiance observations from the existing ARM AERI instruments. We look forward to a time when the ARM-UAV program is able to extend its scope to include the capability for making these high spectral resolution measurements from a UAV platform.« less

Timing performance of the CMS ECAL and prospects for the future

NASA Astrophysics Data System (ADS)

del Re, Daniele

2015-02-01

The CMS electromagnetic calorimeter (ECAL) is made of about 75000 scintillating lead tungstate crystals arranged in a barrel and two endcaps. The scintillation light is read out by avalanche photodiodes in the barrel and vacuum phototriodes in the endcaps, at which point the scintillation pulse is amplified and sampled at 40 MHz by the on-detector electronics. The fast signal from the crystal scintillation enables energy as well as time measurements from the data collected in proton-proton collisions with high energy electrons and photons. The stability of the time measurement required to maintain the energy resolution is on the order of 1 ns. The single-channel time resolution of ECAL measured at beam tests for high energy showers is better than 100 ps. The time resolution achieved with the data collected in proton-proton collisions at the LHC is presented. The time precision achieved is used in important physics measurements and also allows the study of subtle calorimetric effects, such as the time response of different crystals belonging to the same electromagnetic shower. In addition, we present prospects for the high luminosity phase of the LHC, where we expect an average of 140 concurrent interactions per bunch crossing (pile-up). It is currently being studied how precision time could be exploited for pileup mitigation and for the assignment of the collision vertex for photons. In this respect, a detailed understanding of the time performance and of the limiting factors in time resolution will be important.

Patch-Based Super-Resolution of MR Spectroscopic Images: Application to Multiple Sclerosis

PubMed Central

Jain, Saurabh; Sima, Diana M.; Sanaei Nezhad, Faezeh; Hangel, Gilbert; Bogner, Wolfgang; Williams, Stephen; Van Huffel, Sabine; Maes, Frederik; Smeets, Dirk

2017-01-01

Purpose: Magnetic resonance spectroscopic imaging (MRSI) provides complementary information to conventional magnetic resonance imaging. Acquiring high resolution MRSI is time consuming and requires complex reconstruction techniques. Methods: In this paper, a patch-based super-resolution method is presented to increase the spatial resolution of metabolite maps computed from MRSI. The proposed method uses high resolution anatomical MR images (T1-weighted and Fluid-attenuated inversion recovery) to regularize the super-resolution process. The accuracy of the method is validated against conventional interpolation techniques using a phantom, as well as simulated and in vivo acquired human brain images of multiple sclerosis subjects. Results: The method preserves tissue contrast and structural information, and matches well with the trend of acquired high resolution MRSI. Conclusions: These results suggest that the method has potential for clinically relevant neuroimaging applications. PMID:28197066

High-resolution, time-resolved MRA provides superior definition of lower-extremity arterial segments compared to 2D time-of-flight imaging.

PubMed

Thornton, F J; Du, J; Suleiman, S A; Dieter, R; Tefera, G; Pillai, K R; Korosec, F R; Mistretta, C A; Grist, T M

2006-08-01

To evaluate a novel time-resolved contrast-enhanced (CE) projection reconstruction (PR) magnetic resonance angiography (MRA) method for identifying potential bypass graft target vessels in patients with Class II-IV peripheral vascular disease. Twenty patients (M:F = 15:5, mean age = 58 years, range = 48-83 years), were recruited from routine MRA referrals. All imaging was performed on a 1.5 T MRI system with fast gradients (Signa LX; GE Healthcare, Waukesha, WI). Images were acquired with a novel technique that combined undersampled PR with a time-resolved acquisition to yield an MRA method with high temporal and spatial resolution. The method is called PR hyper time-resolved imaging of contrast kinetics (PR-hyperTRICKS). Quantitative and qualitative analyses were used to compare two-dimensional (2D) time-of-flight (TOF) and PR-hyperTRICKS in 13 arterial segments per lower extremity. Statistical analysis was performed with the Wilcoxon signed-rank test. Fifteen percent (77/517) of the vessels were scored as missing or nondiagnostic with 2D TOF, but were scored as diagnostic with PR-hyperTRICKS. Image quality was superior with PR-hyperTRICKS vs. 2D TOF (on a four-point scale, mean rank = 3.3 +/- 1.2 vs. 2.9 +/- 1.2, P < 0.0001). PR-hyperTRICKS produced images with high contrast-to-noise ratios (CNR) and high spatial and temporal resolution. 2D TOF images were of inferior quality due to moderate spatial resolution, inferior CNR, greater flow-related artifacts, and absence of temporal resolution. PR-hyperTRICKS provides superior preoperative assessment of lower limb ischemia compared to 2D TOF.

High-speed MCP anodes for high time resolution low-energy charged particle spectrometers

NASA Astrophysics Data System (ADS)

Saito, Yoshifumi; Yokota, Shoichiro; Asamura, Kazushi; Krieger, Amanda

2017-02-01

The time resolution of low-energy charged particle measurements is becoming higher and higher. In order to realize high time resolution measurements, a 1-D circular delay line anode has been developed as a high-speed microchannel plate (MCP) anode. The maximum count rate of the 1-D circular delay line anode is around 1 × 107/s/360°, which is much higher than the widely used resistive anode, whose maximum count rate is around 1 × 106/s/360°. In order to achieve much higher speeds, an MCP anode with application-specific integrated circuit (ASIC) has been developed. We have decided to adopt an anode configuration in which a discrete anode is formed on a ceramic substrate, and a bare ASIC chip is installed on the back of the ceramic. It has been found that the anode can detect at a high count rate of 2 × 108/s/360°. Developments in both delay line and discrete anodes, as well as readout electronics, will be reviewed.

A Miniature Fiber-Optic Sensor for High-Resolution and High-Speed Temperature Sensing in Ocean Environment

DTIC Science & Technology

2015-11-05

the SMF is superior when it comes to remote sensing in far and deep ocean. As an initial test , the real-time temperature structure within the water...4 ℃. The high resolution guarantees the visualization of subtle variation in the local water. To test the response time of the proposed sensor, the... Honey , "Optical trubulence in the sea," in Underwater Photo-optical Instrumentation Applications SPIE, 49-55 (1972). [6] J. D. Nash, D. R. Caldwell, M

High-performance electronics for time-of-flight PET systems

NASA Astrophysics Data System (ADS)

Choong, W.-S.; Peng, Q.; Vu, C. Q.; Turko, B. T.; Moses, W. W.

2013-01-01

We have designed and built a high-performance readout electronics system for time-of-flight positron emission tomography (TOF PET) cameras. The electronics architecture is based on the electronics for a commercial whole-body PET camera (Siemens/CPS Cardinal electronics), modified to improve the timing performance. The fundamental contributions in the electronics that can limit the timing resolution include the constant fraction discriminator (CFD), which converts the analog electrical signal from the photo-detector to a digital signal whose leading edge is time-correlated with the input signal, and the time-to-digital converter (TDC), which provides a time stamp for the CFD output. Coincident events are identified by digitally comparing the values of the time stamps. In the Cardinal electronics, the front-end processing electronics are performed by an Analog subsection board, which has two application-specific integrated circuits (ASICs), each servicing a PET block detector module. The ASIC has a built-in CFD and TDC. We found that a significant degradation in the timing resolution comes from the ASIC's CFD and TDC. Therefore, we have designed and built an improved Analog subsection board that replaces the ASIC's CFD and TDC with a high-performance CFD (made with discrete components) and TDC (using the CERN high-performance TDC ASIC). The improved Analog subsection board is used in a custom single-ring LSO-based TOF PET camera. The electronics system achieves a timing resolution of 60 ps FWHM. Prototype TOF detector modules are read out with the electronics system and give coincidence timing resolutions of 259 ps FWHM and 156 ps FWHM for detector modules coupled to LSO and LaBr3 crystals respectively.

Rapid Diagnosis of Tuberculosis by Real-Time High-Resolution Imaging of Mycobacterium tuberculosis Colonies.

PubMed

Ghodbane, Ramzi; Asmar, Shady; Betzner, Marlena; Linet, Marie; Pierquin, Joseph; Raoult, Didier; Drancourt, Michel

2015-08-01

Culture remains the cornerstone of diagnosis for pulmonary tuberculosis, but the fastidiousness of Mycobacterium tuberculosis may delay culture-based diagnosis for weeks. We evaluated the performance of real-time high-resolution imaging for the rapid detection of M. tuberculosis colonies growing on a solid medium. A total of 50 clinical specimens, including 42 sputum specimens, 4 stool specimens, 2 bronchoalveolar lavage fluid specimens, and 2 bronchial aspirate fluid specimens were prospectively inoculated into (i) a commercially available Middlebrook broth and evaluated for mycobacterial growth indirectly detected by measuring oxygen consumption (standard protocol) and (ii) a home-made solid medium incubated in an incubator featuring real-time high-resolution imaging of colonies (real-time protocol). Isolates were identified by Ziehl-Neelsen staining and matrix-assisted laser desorption ionization-time of flight mass spectrometry. Use of the standard protocol yielded 14/50 (28%) M. tuberculosis isolates, which is not significantly different from the 13/50 (26%) M. tuberculosis isolates found using the real-time protocol (P = 1.00 by Fisher's exact test), and the contamination rate of 1/50 (2%) was not significantly different from the contamination rate of 2/50 (4%) using the real-time protocol (P = 1.00). The real-time imaging protocol showed a 4.4-fold reduction in time to detection, 82 ± 54 h versus 360 ± 142 h (P < 0.05). These preliminary data give the proof of concept that real-time high-resolution imaging of M. tuberculosis colonies is a new technology that shortens the time to growth detection and the laboratory diagnosis of pulmonary tuberculosis. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

High-performance electronics for time-of-flight PET systems.

PubMed

Choong, W-S; Peng, Q; Vu, C Q; Turko, B T; Moses, W W

2013-01-01

We have designed and built a high-performance readout electronics system for time-of-flight positron emission tomography (TOF PET) cameras. The electronics architecture is based on the electronics for a commercial whole-body PET camera (Siemens/CPS Cardinal electronics), modified to improve the timing performance. The fundamental contributions in the electronics that can limit the timing resolution include the constant fraction discriminator (CFD), which converts the analog electrical signal from the photo-detector to a digital signal whose leading edge is time-correlated with the input signal, and the time-to-digital converter (TDC), which provides a time stamp for the CFD output. Coincident events are identified by digitally comparing the values of the time stamps. In the Cardinal electronics, the front-end processing electronics are performed by an Analog subsection board, which has two application-specific integrated circuits (ASICs), each servicing a PET block detector module. The ASIC has a built-in CFD and TDC. We found that a significant degradation in the timing resolution comes from the ASIC's CFD and TDC. Therefore, we have designed and built an improved Analog subsection board that replaces the ASIC's CFD and TDC with a high-performance CFD (made with discrete components) and TDC (using the CERN high-performance TDC ASIC). The improved Analog subsection board is used in a custom single-ring LSO-based TOF PET camera. The electronics system achieves a timing resolution of 60 ps FWHM. Prototype TOF detector modules are read out with the electronics system and give coincidence timing resolutions of 259 ps FWHM and 156 ps FWHM for detector modules coupled to LSO and LaBr 3 crystals respectively.

Example-Based Super-Resolution Fluorescence Microscopy.

PubMed

Jia, Shu; Han, Boran; Kutz, J Nathan

2018-04-23

Capturing biological dynamics with high spatiotemporal resolution demands the advancement in imaging technologies. Super-resolution fluorescence microscopy offers spatial resolution surpassing the diffraction limit to resolve near-molecular-level details. While various strategies have been reported to improve the temporal resolution of super-resolution imaging, all super-resolution techniques are still fundamentally limited by the trade-off associated with the longer image acquisition time that is needed to achieve higher spatial information. Here, we demonstrated an example-based, computational method that aims to obtain super-resolution images using conventional imaging without increasing the imaging time. With a low-resolution image input, the method provides an estimate of its super-resolution image based on an example database that contains super- and low-resolution image pairs of biological structures of interest. The computational imaging of cellular microtubules agrees approximately with the experimental super-resolution STORM results. This new approach may offer potential improvements in temporal resolution for experimental super-resolution fluorescence microscopy and provide a new path for large-data aided biomedical imaging.

A depth-encoding PET detector that uses light sharing and single-ended readout with silicon photomultipliers

NASA Astrophysics Data System (ADS)

Kuang, Zhonghua; Yang, Qian; Wang, Xiaohui; Fu, Xin; Ren, Ning; Sang, Ziru; Wu, San; Zheng, Yunfei; Zhang, Xianming; Hu, Zhanli; Du, Junwei; Liang, Dong; Liu, Xin; Zheng, Hairong; Yang, Yongfeng

2018-02-01

Detectors with depth-encoding capability and good timing resolution are required to develop high-performance whole-body or total-body PET scanners. In this work, depth-encoding PET detectors that use light sharing between two discrete crystals and single-ended readout with silicon photomultipliers (SiPMs) were manufactured and evaluated. The detectors consisted of two unpolished 3  ×  3  ×  20 mm3 LYSO crystals with different coupling materials between them and were read out by Hamamatsu 3  ×  3 mm2 SiPMs with one-to-one coupling. The ratio of the energy of one SiPM to the total energy of two SiPMs was used to measure the depth of interaction (DOI). Detectors with different coupling materials in-between the crystals were measured in the singles mode in an effort to obtain detectors that can provide good DOI resolution. The DOI resolution and energy resolution of three types of detector were measured and the timing resolution was measured for the detector with the best DOI and energy resolution. The optimum detector, with 5 mm optical glue, a 9 mm triangular ESR and a 6 mm rectangular ESR in-between the unpolished crystals, provides a DOI resolution of 2.65 mm, an energy resolution of 10.0% and a timing resolution of 427 ps for events of E  >  400 keV. The detectors simultaneously provide good DOI and timing resolution, and show great promise for the development of high-performance whole-body and total-body PET scanners.

Novel crystal timing calibration method based on total variation

NASA Astrophysics Data System (ADS)

Yu, Xingjian; Isobe, Takashi; Watanabe, Mitsuo; Liu, Huafeng

2016-11-01

A novel crystal timing calibration method based on total variation (TV), abbreviated as ‘TV merge’, has been developed for a high-resolution positron emission tomography (PET) system. The proposed method was developed for a system with a large number of crystals, it can provide timing calibration at the crystal level. In the proposed method, the timing calibration process was formulated as a linear problem. To robustly optimize the timing resolution, a TV constraint was added to the linear equation. Moreover, to solve the computer memory problem associated with the calculation of the timing calibration factors for systems with a large number of crystals, the merge component was used for obtaining the crystal level timing calibration values. Compared with other conventional methods, the data measured from a standard cylindrical phantom filled with a radioisotope solution was sufficient for performing a high-precision crystal-level timing calibration. In this paper, both simulation and experimental studies were performed to demonstrate the effectiveness and robustness of the TV merge method. We compare the timing resolutions of a 22Na point source, which was located in the field of view (FOV) of the brain PET system, with various calibration techniques. After implementing the TV merge method, the timing resolution improved from 3.34 ns at full width at half maximum (FWHM) to 2.31 ns FWHM.

Whole-animal imaging with high spatio-temporal resolution

NASA Astrophysics Data System (ADS)

Chhetri, Raghav; Amat, Fernando; Wan, Yinan; Höckendorf, Burkhard; Lemon, William C.; Keller, Philipp J.

2016-03-01

We developed isotropic multiview (IsoView) light-sheet microscopy in order to image fast cellular dynamics, such as cell movements in an entire developing embryo or neuronal activity throughput an entire brain or nervous system, with high resolution in all dimensions, high imaging speeds, good physical coverage and low photo-damage. To achieve high temporal resolution and high spatial resolution at the same time, IsoView microscopy rapidly images large specimens via simultaneous light-sheet illumination and fluorescence detection along four orthogonal directions. In a post-processing step, these four views are then combined by means of high-throughput multiview deconvolution to yield images with a system resolution of ≤ 450 nm in all three dimensions. Using IsoView microscopy, we performed whole-animal functional imaging of Drosophila embryos and larvae at a spatial resolution of 1.1-2.5 μm and at a temporal resolution of 2 Hz for up to 9 hours. We also performed whole-brain functional imaging in larval zebrafish and multicolor imaging of fast cellular dynamics across entire, gastrulating Drosophila embryos with isotropic, sub-cellular resolution. Compared with conventional (spatially anisotropic) light-sheet microscopy, IsoView microscopy improves spatial resolution at least sevenfold and decreases resolution anisotropy at least threefold. Compared with existing high-resolution light-sheet techniques, such as lattice lightsheet microscopy or diSPIM, IsoView microscopy effectively doubles the penetration depth and provides subsecond temporal resolution for specimens 400-fold larger than could previously be imaged.

FALCON: fast and unbiased reconstruction of high-density super-resolution microscopy data

NASA Astrophysics Data System (ADS)

Min, Junhong; Vonesch, Cédric; Kirshner, Hagai; Carlini, Lina; Olivier, Nicolas; Holden, Seamus; Manley, Suliana; Ye, Jong Chul; Unser, Michael

2014-04-01

Super resolution microscopy such as STORM and (F)PALM is now a well known method for biological studies at the nanometer scale. However, conventional imaging schemes based on sparse activation of photo-switchable fluorescent probes have inherently slow temporal resolution which is a serious limitation when investigating live-cell dynamics. Here, we present an algorithm for high-density super-resolution microscopy which combines a sparsity-promoting formulation with a Taylor series approximation of the PSF. Our algorithm is designed to provide unbiased localization on continuous space and high recall rates for high-density imaging, and to have orders-of-magnitude shorter run times compared to previous high-density algorithms. We validated our algorithm on both simulated and experimental data, and demonstrated live-cell imaging with temporal resolution of 2.5 seconds by recovering fast ER dynamics.

FALCON: fast and unbiased reconstruction of high-density super-resolution microscopy data

PubMed Central

Min, Junhong; Vonesch, Cédric; Kirshner, Hagai; Carlini, Lina; Olivier, Nicolas; Holden, Seamus; Manley, Suliana; Ye, Jong Chul; Unser, Michael

2014-01-01

Super resolution microscopy such as STORM and (F)PALM is now a well known method for biological studies at the nanometer scale. However, conventional imaging schemes based on sparse activation of photo-switchable fluorescent probes have inherently slow temporal resolution which is a serious limitation when investigating live-cell dynamics. Here, we present an algorithm for high-density super-resolution microscopy which combines a sparsity-promoting formulation with a Taylor series approximation of the PSF. Our algorithm is designed to provide unbiased localization on continuous space and high recall rates for high-density imaging, and to have orders-of-magnitude shorter run times compared to previous high-density algorithms. We validated our algorithm on both simulated and experimental data, and demonstrated live-cell imaging with temporal resolution of 2.5 seconds by recovering fast ER dynamics. PMID:24694686

Impacts of high resolution data on traveler compliance levels in emergency evacuation simulations

DOE PAGES

Lu, Wei; Han, Lee D.; Liu, Cheng; ...

2016-05-05

In this article, we conducted a comparison study of evacuation assignment based on Traffic Analysis Zones (TAZ) and high resolution LandScan USA Population Cells (LPC) with detailed real world roads network. A platform for evacuation modeling built on high resolution population distribution data and activity-based microscopic traffic simulation was proposed. This platform can be extended to any cities in the world. The results indicated that evacuee compliance behavior affects evacuation efficiency with traditional TAZ assignment, but it did not significantly compromise the performance with high resolution LPC assignment. The TAZ assignment also underestimated the real travel time during evacuation. Thismore » suggests that high data resolution can improve the accuracy of traffic modeling and simulation. The evacuation manager should consider more diverse assignment during emergency evacuation to avoid congestions.« less

Note: Tandem Kirkpatrick-Baez microscope with sixteen channels for high-resolution laser-plasma diagnostics

NASA Astrophysics Data System (ADS)

Yi, Shengzhen; Zhang, Zhe; Huang, Qiushi; Zhang, Zhong; Wang, Zhanshan; Wei, Lai; Liu, Dongxiao; Cao, Leifeng; Gu, Yuqiu

2018-03-01

Multi-channel Kirkpatrick-Baez (KB) microscopes, which have better resolution and collection efficiency than pinhole cameras, have been widely used in laser inertial confinement fusion to diagnose time evolution of the target implosion. In this study, a tandem multi-channel KB microscope was developed to have sixteen imaging channels with the precise control of spatial resolution and image intervals. This precise control was created using a coarse assembly of mirror pairs with high-accuracy optical prisms, followed by precise adjustment in real-time x-ray imaging experiments. The multilayers coated on the KB mirrors were designed to have substantially the same reflectivity to obtain a uniform brightness of different images for laser-plasma temperature analysis. The study provides a practicable method to achieve the optimum performance of the microscope for future high-resolution applications in inertial confinement fusion experiments.

Real-time and quantitative isotropic spatial resolution susceptibility imaging for magnetic nanoparticles

NASA Astrophysics Data System (ADS)

Pi, Shiqiang; Liu, Wenzhong; Jiang, Tao

2018-03-01

The magnetic transparency of biological tissue allows the magnetic nanoparticle (MNP) to be a promising functional sensor and contrast agent. The complex susceptibility of MNPs, strongly influenced by particle concentration, excitation magnetic field and their surrounding microenvironment, provides significant implications for biomedical applications. Therefore, magnetic susceptibility imaging of high spatial resolution will give more detailed information during the process of MNP-aided diagnosis and therapy. In this study, we present a novel spatial magnetic susceptibility extraction method for MNPs under a gradient magnetic field, a low-frequency drive magnetic field, and a weak strength high-frequency magnetic field. Based on this novel method, a magnetic particle susceptibility imaging (MPSI) of millimeter-level spatial resolution (<3 mm) was achieved using our homemade imaging system. Corroborated by the experimental results, the MPSI shows real-time (1 s per frame acquisition) and quantitative abilities, and isotropic high resolution.

Flash chemistry: flow microreactor synthesis based on high-resolution reaction time control.

PubMed

Yoshida, Jun-ichi

2010-10-01

This article addresses a fascinating aspect of flash chemistry, high-resolution reaction-time control by virtue of a flow microreactor system, and its applications. The length of time that the solution remains inside the reactor is called the residence time. The residence time between the addition of a reagent and that of a quenching agent or the next reagent in a flow microreactor is the reaction time, and the reaction time can be greatly reduced by adjusting the length of a reaction channel in a flow microreactor. This feature is quite effective for conducting reactions involving short-lived reactive intermediates. A reactive species can be generated and transferred to another location to be used in the next reaction before it decomposes by adjusting the residence time in the millisecond to second timescale. The principle of such high-resolution reaction-time control, which can be achieved only by flow microreactors, and its applications to synthetic reactions including Swern-Moffatt-type oxidation, as well as the generation and reactions of aryllithium compounds bearing electrophilic substituents, such as alkoxycarbonyl groups, are presented. Integration of such reactions using integrated flow microreactor systems is also demonstrated. © 2010 The Japan Chemical Journal Forum and Wiley Periodicals, Inc.

DMI's Baltic Sea Coastal operational forecasting system

NASA Astrophysics Data System (ADS)

Murawski, Jens; Berg, Per; Weismann Poulsen, Jacob

2017-04-01

Operational forecasting is challenged with bridging the gap between the large scales of the driving weather systems and the local, human scales of the model applications. The limit of what can be represented by local model has been continuously shifted to higher and higher spatial resolution, with the aim to better resolve the local dynamic and to make it possible to describe processes that could only be parameterised in older versions, with the ultimate goal to improve the quality of the forecast. Current hardware trends demand a str onger focus on the development of efficient, highly parallelised software and require a refactoring of the code with a solid focus on portable performance. The gained performance can be used for running high resolution model with a larger coverage. Together with the development of efficient two-way nesting routines, this has made it possible to approach the near-coastal zone with model applications that can run in a time effective way. Denmarks Meteorological Institute uses the HBM(1) ocean circulation model for applications that covers the entire Baltic Sea and North Sea with an integrated model set-up that spans the range of horizontal resolution from 1nm for the entire Baltic Sea to approx. 200m resolution in local fjords (Limfjord). For the next model generation, the high resolution set-ups are going to be extended and new high resolution domains in coastal zones are either implemented or tested for operational use. For the first time it will be possible to cover large stretches of the Baltic coastal zone with sufficiently high resolution to model the local hydrodynamic adequately. (1) HBM stands for HIROMB-BOOS-Model, whereas HIROMB stands for "High Resolution Model for the Baltic Sea" and BOOS stands for "Baltic Operational Oceanography System".

Remote sensing in support of high-resolution terrestrial carbon monitoring and modeling

NASA Astrophysics Data System (ADS)

Hurtt, G. C.; Zhao, M.; Dubayah, R.; Huang, C.; Swatantran, A.; ONeil-Dunne, J.; Johnson, K. D.; Birdsey, R.; Fisk, J.; Flanagan, S.; Sahajpal, R.; Huang, W.; Tang, H.; Armstrong, A. H.

2014-12-01

As part of its Phase 1 Carbon Monitoring System (CMS) activities, NASA initiated a Local-Scale Biomass Pilot study. The goals of the pilot study were to develop protocols for fusing high-resolution remotely sensed observations with field data, provide accurate validation test areas for the continental-scale biomass product, and demonstrate efficacy for prognostic terrestrial ecosystem modeling. In Phase 2, this effort was expanded to the state scale. Here, we present results of this activity focusing on the use of remote sensing in high-resolution ecosystem modeling. The Ecosystem Demography (ED) model was implemented at 90 m spatial resolution for the entire state of Maryland. We rasterized soil depth and soil texture data from SSURGO. For hourly meteorological data, we spatially interpolated 32-km 3-hourly NARR into 1-km hourly and further corrected them at monthly level using PRISM data. NLCD data were used to mask sand, seashore, and wetland. High-resolution 1 m forest/non-forest mapping was used to define forest fraction of 90 m cells. Three alternative strategies were evaluated for initialization of forest structure using high-resolution lidar, and the model was used to calculate statewide estimates of forest biomass, carbon sequestration potential, time to reach sequestration potential, and sensitivity to future forest growth and disturbance rates, all at 90 m resolution. To our knowledge, no dynamic ecosystem model has been run at such high spatial resolution over such large areas utilizing remote sensing and validated as extensively. There are over 3 million 90 m land cells in Maryland, greater than 43 times the ~73,000 half-degree cells in a state-of-the-art global land model.

High Resolution PET Imaging Probe for the Detection, Molecular Characterization, and Treatment Monitoring of Prostate cancer

DTIC Science & Technology

2011-07-01

impact on overall probe performance, including spatial resolution, energy resolution and timing resolution. We will show that 1 mm3 voxels will...ring, description of a strategy to remove scattered events, followed by characterization of impact of timing properties of the probe. In summary, the...described by the total distance d¼d1+d2 and a¼ d1=ðd1þd2Þ. We also want to account for impact angles, y1 and y2, defined versus line perpendicular to

Timing capabilities of garnet crystals for detection of high energy charged particles

NASA Astrophysics Data System (ADS)

Lucchini, M. T.; Gundacker, S.; Lecoq, P.; Benaglia, A.; Nikl, M.; Kamada, K.; Yoshikawa, A.; Auffray, E.

2017-04-01

Particle detectors at future collider experiments will operate at high collision rates and thus will have to face high pile up and a harsh radiation environment. Precision timing capabilities can help in the reconstruction of physics events by mitigating pile up effects. In this context, radiation tolerant, scintillating crystals coupled to silicon photomultipliers (SiPMs) can provide a flexible and compact option for the implementation of a precision timing layer inside large particle detectors. In this paper, we compare the timing performance of aluminum garnet crystals (YAG: Ce, LuAG: Ce, GAGG: Ce) and the improvements of their time resolution by means of codoping with Mg2+ ions. The crystals were read out using SiPMs from Hamamatsu glued to the rear end of the scintillator and their timing performance was evaluated by measuring the coincidence time resolution (CTR) of 150 GeV charged pions traversing a pair of crystals. The influence of crystal properties, such as density, light yield and decay kinetics on the timing performance is discussed. The best single detector time resolutions are in the range of 23-30 ps (sigma) and only achieved by codoping the garnet crystals with divalent ions, such as Mg2+. The much faster scintillation decay in the co-doped samples as compared to non co-doped garnets explains the higher timing performance. Samples of LSO: Ce, Ca and LYSO:Ce crystals have also been used as reference time device and showed a time resolution at the level of 17 ps, in agreement with previous results.

High-speed, random-access fluorescence microscopy: I. High-resolution optical recording with voltage-sensitive dyes and ion indicators.

PubMed

Bullen, A; Patel, S S; Saggau, P

1997-07-01

The design and implementation of a high-speed, random-access, laser-scanning fluorescence microscope configured to record fast physiological signals from small neuronal structures with high spatiotemporal resolution is presented. The laser-scanning capability of this nonimaging microscope is provided by two orthogonal acousto-optic deflectors under computer control. Each scanning point can be randomly accessed and has a positioning time of 3-5 microseconds. Sampling time is also computer-controlled and can be varied to maximize the signal-to-noise ratio. Acquisition rates up to 200k samples/s at 16-bit digitizing resolution are possible. The spatial resolution of this instrument is determined by the minimal spot size at the level of the preparation (i.e., 2-7 microns). Scanning points are selected interactively from a reference image collected with differential interference contrast optics and a video camera. Frame rates up to 5 kHz are easily attainable. Intrinsic variations in laser light intensity and scanning spot brightness are overcome by an on-line signal-processing scheme. Representative records obtained with this instrument by using voltage-sensitive dyes and calcium indicators demonstrate the ability to make fast, high-fidelity measurements of membrane potential and intracellular calcium at high spatial resolution (2 microns) without any temporal averaging.

High-speed, random-access fluorescence microscopy: I. High-resolution optical recording with voltage-sensitive dyes and ion indicators.

PubMed Central

Bullen, A; Patel, S S; Saggau, P

1997-01-01

The design and implementation of a high-speed, random-access, laser-scanning fluorescence microscope configured to record fast physiological signals from small neuronal structures with high spatiotemporal resolution is presented. The laser-scanning capability of this nonimaging microscope is provided by two orthogonal acousto-optic deflectors under computer control. Each scanning point can be randomly accessed and has a positioning time of 3-5 microseconds. Sampling time is also computer-controlled and can be varied to maximize the signal-to-noise ratio. Acquisition rates up to 200k samples/s at 16-bit digitizing resolution are possible. The spatial resolution of this instrument is determined by the minimal spot size at the level of the preparation (i.e., 2-7 microns). Scanning points are selected interactively from a reference image collected with differential interference contrast optics and a video camera. Frame rates up to 5 kHz are easily attainable. Intrinsic variations in laser light intensity and scanning spot brightness are overcome by an on-line signal-processing scheme. Representative records obtained with this instrument by using voltage-sensitive dyes and calcium indicators demonstrate the ability to make fast, high-fidelity measurements of membrane potential and intracellular calcium at high spatial resolution (2 microns) without any temporal averaging. Images FIGURE 6 PMID:9199810

LYSO based precision timing calorimeters

NASA Astrophysics Data System (ADS)

Bornheim, A.; Apresyan, A.; Ronzhin, A.; Xie, S.; Duarte, J.; Spiropulu, M.; Trevor, J.; Anderson, D.; Pena, C.; Hassanshahi, M. H.

2017-11-01

In this report we outline the study of the development of calorimeter detectors using bright scintillating crystals. We discuss how timing information with a precision of a few tens of pico seconds and below can significantly improve the reconstruction of the physics events under challenging high pileup conditions to be faced at the High-Luminosity LHC or a future hadron collider. The particular challenge in measuring the time of arrival of a high energy photon lies in the stochastic component of the distance of initial conversion and the size of the electromagnetic shower. We present studies and measurements from test beams for calorimeter based timing measurements to explore the ultimate timing precision achievable for high energy photons of 10 GeV and above. We focus on techniques to measure the timing with a high precision in association with the energy of the photon. We present test-beam studies and results on the timing performance and characterization of the time resolution of LYSO-based calorimeters. We demonstrate time resolution of 30 ps is achievable for a particular design.

Real-time and sub-wavelength ultrafast coherent diffraction imaging in the extreme ultraviolet.

PubMed

Zürch, M; Rothhardt, J; Hädrich, S; Demmler, S; Krebs, M; Limpert, J; Tünnermann, A; Guggenmos, A; Kleineberg, U; Spielmann, C

2014-12-08

Coherent Diffraction Imaging is a technique to study matter with nanometer-scale spatial resolution based on coherent illumination of the sample with hard X-ray, soft X-ray or extreme ultraviolet light delivered from synchrotrons or more recently X-ray Free-Electron Lasers. This robust technique simultaneously allows quantitative amplitude and phase contrast imaging. Laser-driven high harmonic generation XUV-sources allow table-top realizations. However, the low conversion efficiency of lab-based sources imposes either a large scale laser system or long exposure times, preventing many applications. Here we present a lensless imaging experiment combining a high numerical aperture (NA = 0.8) setup with a high average power fibre laser driven high harmonic source. The high flux and narrow-band harmonic line at 33.2 nm enables either sub-wavelength spatial resolution close to the Abbe limit (Δr = 0.8λ) for long exposure time, or sub-70 nm imaging in less than one second. The unprecedented high spatial resolution, compactness of the setup together with the real-time capability paves the way for a plethora of applications in fundamental and life sciences.

A Compressed Sensing Based Method for Reducing the Sampling Time of A High Resolution Pressure Sensor Array System

PubMed Central

Sun, Chenglu; Li, Wei; Chen, Wei

2017-01-01

For extracting the pressure distribution image and respiratory waveform unobtrusively and comfortably, we proposed a smart mat which utilized a flexible pressure sensor array, printed electrodes and novel soft seven-layer structure to monitor those physiological information. However, in order to obtain high-resolution pressure distribution and more accurate respiratory waveform, it needs more time to acquire the pressure signal of all the pressure sensors embedded in the smart mat. In order to reduce the sampling time while keeping the same resolution and accuracy, a novel method based on compressed sensing (CS) theory was proposed. By utilizing the CS based method, 40% of the sampling time can be decreased by means of acquiring nearly one-third of original sampling points. Then several experiments were carried out to validate the performance of the CS based method. While less than one-third of original sampling points were measured, the correlation degree coefficient between reconstructed respiratory waveform and original waveform can achieve 0.9078, and the accuracy of the respiratory rate (RR) extracted from the reconstructed respiratory waveform can reach 95.54%. The experimental results demonstrated that the novel method can fit the high resolution smart mat system and be a viable option for reducing the sampling time of the pressure sensor array. PMID:28796188

High resolution humidity, temperature and aerosol profiling with MeteoSwiss Raman lidar

NASA Astrophysics Data System (ADS)

Dinoev, Todor; Arshinov, Yuri; Bobrovnikov, Sergei; Serikov, Ilya; Calpini, Bertrand; van den Bergh, Hubert; Parlange, Marc B.; Simeonov, Valentin

2010-05-01

Meteorological services rely, in part, on numerical weather prediction (NWP). Twice a day radiosonde observations of water vapor provide the required data for assimilation but this time resolution is insufficient to resolve certain meteorological phenomena. High time resolution temperature profiles from microwave radiometers are available as well but have rather low vertical resolution. The Raman LIDARs are able to provide temperature and humidity profiles with high time and range resolution, suitable for NWP model assimilation and validation. They are as well indispensible tools for continuous aerosol profiling for high resolution atmospheric boundary layer studies. To improve the database available for direct meteorological applications the Swiss meteo-service (MeteoSwiss), the Swiss Federal Institute of Technology in Lausanne (EPFL) and the Swiss National Science Foundation (SNSF) initiated a project to design and build an automated Raman lidar for day and night vertical profiling of tropospheric water vapor with the possibility to further upgrade it with an aerosol and temperature channels. The project was initiated in 2004 and RALMO (Raman Lidar for meteorological observations) was inaugurated in August 2008 at MeteoSwiss aerological station at Payerne. RALMO is currently operational and continuously profiles water vapor mixing ratio, aerosol backscatter ratio and aerosol extinction. The instrument is a fully automated, self-contained, eye-safe Raman lidar operated at 355 nm. Narrow field-of-view multi-telescope receiver and narrow band detection allow day and night-time vertical profiling of the atmospheric humidity. The rotational-vibrational Raman lidar responses from water vapor and nitrogen are spectrally separated by a high-throughput fiber coupled diffraction grating polychromator. The elastic backscatter and pure-rotational Raman lidar responses (PRR) from oxygen and nitrogen are spectrally isolated by a double grating polychromator and are used to derive vertical profiles of aerosol backscatter ratio and aerosol extinction at 355 nm. Set of Stokes and anti-Stokes PRR lines are separated by the polychromator to derive temperature profiles. The humidity profiles have vertical resolution from 15 m (within the boundary layer) to 100-450 m (within the free troposphere), time resolution of 30 min and 5 km vertical range at daytime and 10 km at night-time. The aerosol backscatter ratio and extinction profiles have similar resolution with vertical range of approximately 10 km. The temperature profiles are derived from PRR lidar signals, simultaneously recorded in analog and photon counting mode, allowing vertical range of approximately 10 km. Vaisala RS-92 and Snow-White chilled mirror hygrometer radiosondes were used for calibration of the water vapor and temperature channels. Continuous temperature profiles were obtained and were coupled with the available water vapor mixing ratio profiles to obtain relative humidity time series. Lidar derived aerosol backscatter ratio profiles will be used for estimation of the boundary layer height and validation of NWP model results. Optical thickness time series are currently compared to independent measurements from a collocated sun photometer to assess the performance of the aerosol channel.

Applications of High-Resolution LiDAR Data for the Christina River Basin CZO

NASA Astrophysics Data System (ADS)

Hicks, N. S.; Aufdenkampe, A. K.; Hicks, S. D.

2011-12-01

High-resolution LiDAR data allows for fine scale geomorphic assessment over relatively large spatial extents. Previously available DEMs with a resolution of ten meters or more did not provide adequate resolution for geomorphic characterization of small streams and watersheds or the identification of changes in stream morphology over time. High-resolution LiDAR data for a portion of the Christina River Basin Critical Zone Observatory (CRB-CZO) was obtained during both leaf-off and leaf-on time periods in 2010. Topographic data from these flights is being analyzed with the intent of geomorphic applications such as stream morphology, sediment transport studies, and the evaluation of alluvial deposits. These data and resultant products will also be used in hydrologic and biogeochemical modeling and in biologic and biogeochemical studies of these streams, which are long-term study sites. The LiDAR data also facilitate informed instrument placement and will be used for vegetation studies. The LiDAR data for the CRB-CZO has been used to create a variety of LiDAR based topographic data products including TINs and 0.5-m DEMs. LiDAR derived slope and elevation products were combined with LiDAR intensity images to identify stream channel boundaries and stream centerlines for third through first-order streams. High-resolution slope data also aided in floodplain characterization of these small streams. These high precision stream channel and floodplain characterizations would not have been otherwise possible without extensive field surveying. Future LiDAR flights will allow for the identification of changes in channel morphology over time in low order basins. These characterizations are of particular interest in comparisons between forested and meadow reaches, and in studying the effects of changes in land-use on channel morphology. High-resolution LiDAR data allow for the generation of surface characterizations of importance to a wide range of interdisciplinary researchers.

Robust Hydrological Forecasting for High-resolution Distributed Models Using a Unified Data Assimilation Approach

NASA Astrophysics Data System (ADS)

Hernandez, F.; Liang, X.

2017-12-01

Reliable real-time hydrological forecasting, to predict important phenomena such as floods, is invaluable to the society. However, modern high-resolution distributed models have faced challenges when dealing with uncertainties that are caused by the large number of parameters and initial state estimations involved. Therefore, to rely on these high-resolution models for critical real-time forecast applications, considerable improvements on the parameter and initial state estimation techniques must be made. In this work we present a unified data assimilation algorithm called Optimized PareTo Inverse Modeling through Inverse STochastic Search (OPTIMISTS) to deal with the challenge of having robust flood forecasting for high-resolution distributed models. This new algorithm combines the advantages of particle filters and variational methods in a unique way to overcome their individual weaknesses. The analysis of candidate particles compares model results with observations in a flexible time frame, and a multi-objective approach is proposed which attempts to simultaneously minimize differences with the observations and departures from the background states by using both Bayesian sampling and non-convex evolutionary optimization. Moreover, the resulting Pareto front is given a probabilistic interpretation through kernel density estimation to create a non-Gaussian distribution of the states. OPTIMISTS was tested on a low-resolution distributed land surface model using VIC (Variable Infiltration Capacity) and on a high-resolution distributed hydrological model using the DHSVM (Distributed Hydrology Soil Vegetation Model). In the tests streamflow observations are assimilated. OPTIMISTS was also compared with a traditional particle filter and a variational method. Results show that our method can reliably produce adequate forecasts and that it is able to outperform those resulting from assimilating the observations using a particle filter or an evolutionary 4D variational method alone. In addition, our method is shown to be efficient in tackling high-resolution applications with robust results.

Getting to the point: Rapid point selection and variable density InSAR time series for urban deformation monitoring

NASA Astrophysics Data System (ADS)

Spaans, K.; Hooper, A. J.

2017-12-01

The short revisit time and high data acquisition rates of current satellites have resulted in increased interest in the development of deformation monitoring and rapid disaster response capability, using InSAR. Fast, efficient data processing methodologies are required to deliver the timely results necessary for this, and also to limit computing resources required to process the large quantities of data being acquired. Contrary to volcano or earthquake applications, urban monitoring requires high resolution processing, in order to differentiate movements between buildings, or between buildings and the surrounding land. Here we present Rapid time series InSAR (RapidSAR), a method that can efficiently update high resolution time series of interferograms, and demonstrate its effectiveness over urban areas. The RapidSAR method estimates the coherence of pixels on an interferogram-by-interferogram basis. This allows for rapid ingestion of newly acquired images without the need to reprocess the earlier acquired part of the time series. The coherence estimate is based on ensembles of neighbouring pixels with similar amplitude behaviour through time, which are identified on an initial set of interferograms, and need be re-evaluated only occasionally. By taking into account scattering properties of points during coherence estimation, a high quality coherence estimate is achieved, allowing point selection at full resolution. The individual point selection maximizes the amount of information that can be extracted from each interferogram, as no selection compromise has to be reached between high and low coherence interferograms. In other words, points do not have to be coherent throughout the time series to contribute to the deformation time series. We demonstrate the effectiveness of our method over urban areas in the UK. We show how the algorithm successfully extracts high density time series from full resolution Sentinel-1 interferograms, and distinguish clearly between buildings and surrounding vegetation or streets. The fact that new interferograms can be processed separately from the remainder of the time series helps manage the high data volumes, both in space and time, generated by current missions.

Analysis of bovine milk caseins on organic monolithic columns: an integrated capillary liquid chromatography-high resolution mass spectrometry approach for the study of time-dependent casein degradation.

PubMed

Pierri, Giuseppe; Kotoni, Dorina; Simone, Patrizia; Villani, Claudio; Pepe, Giacomo; Campiglia, Pietro; Dugo, Paola; Gasparrini, Francesco

2013-10-25

Casein proteins constitute approximately 80% of the proteins present in bovine milk and account for many of its nutritional and technological properties. The analysis of the casein fraction in commercially available pasteurized milk and the study of its time-dependent degradation is of considerable interest in the agro-food industry. Here we present new analytical methods for the study of caseins in fresh and expired bovine milk, based on the use of lab-made capillary organic monolithic columns. An integrated capillary high performance liquid chromatography and high-resolution mass spectrometry (Cap-LC-HRMS) approach was developed, exploiting the excellent resolution, permeability and biocompatibility of organic monoliths, which is easily adaptable to the analysis of intact proteins. The resolution obtained on the lab-made Protein-Cap-RP-Lauryl-γ-Monolithic column (270 mm × 0.250 mm length × internal diameter, L × I.D.) in the analysis of commercial standard caseins (αS-CN, β-CN and κ-CN) through Cap-HPLC-UV was compared to the one observe using two packed capillary C4 columns, the ACE C4 (3 μm, 150 mm × 0.300 mm, L × I.D.) and the Jupiter C4 column (5 μm, 150 mm × 0.300 mm, L × I.D.). Thanks to the higher resolution observed, the monolithic capillary column was chosen for the successive degradation studies of casein fractions extracted from bovine milk 1-4 weeks after expiry date. The comparison of the UV chromatographic profiles of skim, semi-skim and whole milk showed a major stability of whole milk towards time-dependent degradation of caseins, which was further sustained by high-resolution analysis on a 50-cm long monolithic column using a 120-min time gradient. Contemporarily, the exact monoisotopic and average molecular masses of intact αS-CN and β-CN protein standards were obtained through high resolution mass spectrometry and used for casein identification in Cap-LC-HRMS analysis. Finally, the proteolytic degradation of β-CN in skim milk and the contemporary formation of low-molecular-weight proteose-peptones (PP) with exact monoisotopic Mr between 9444.0989 Da and 14098.9861 Da was confirmed through the deconvolution of high resolution mass spectra and literature data. Copyright © 2013 Elsevier B.V. All rights reserved.

Coupling high-resolution hydraulic and hydrologic models for flash flood forecasting and inundation mapping in urban areas - A case study for the City of Fort Worth

NASA Astrophysics Data System (ADS)

Nazari, B.; Seo, D.; Cannon, A.

2013-12-01

With many diverse features such as channels, pipes, culverts, buildings, etc., hydraulic modeling in urban areas for inundation mapping poses significant challenges. Identifying the practical extent of the details to be modeled in order to obtain sufficiently accurate results in a timely manner for effective emergency management is one of them. In this study we assess the tradeoffs between model complexity vs. information content for decision making in applying high-resolution hydrologic and hydraulic models for real-time flash flood forecasting and inundation mapping in urban areas. In a large urban area such as the Dallas-Fort Worth Metroplex (DFW), there exists very large spatial variability in imperviousness depending on the area of interest. As such, one may expect significant sensitivity of hydraulic model results to the resolution and accuracy of hydrologic models. In this work, we present the initial results from coupling of high-resolution hydrologic and hydraulic models for two 'hot spots' within the City of Fort Worth for real-time inundation mapping.

PEPSI-feed: linking PEPSI to the Vatican Advanced Technology Telescope using a 450m long fibre

NASA Astrophysics Data System (ADS)

Sablowski, D. P.; Weber, M.; Woche, M.; Ilyin, I.; Järvinen, A.; Strassmeier, K. G.; Gabor, P.

2016-07-01

Limited observing time at large telescopes equipped with the most powerful spectrographs makes it almost impossible to gain long and well-sampled time-series observations. Ditto, high-time-resolution observations of bright targets with high signal-to-noise are rare. By pulling an optical fibre of 450m length from the Vatican Advanced Technology Telescope (VATT) to the Large Binocular Telescope (LBT) to connect the Potsdam Echelle Polarimetric and Spectroscopic Instrument (PEPSI) to the VATT, allows for ultra-high resolution time-series measurements of bright targets. This article presents the fibre-link in detail from the technical point-of-view, demonstrates its performance from first observations, and sketches current applications.

Beyond the resolution limit: subpixel resolution in animals and now in silicon

NASA Astrophysics Data System (ADS)

Wilcox, M. J.

2007-09-01

Automatic acquisition of aerial threats at thousands of kilometers distance requires high sensitivity to small differences in contrast and high optical quality for subpixel resolution, since targets occupy much less surface area than a single pixel. Targets travel at high speed and break up in the re-entry phase. Target/decoy discrimination at the earliest possible time is imperative. Real time performance requires a multifaceted approach with hyperspectral imaging and analog processing allowing feature extraction in real time. Hyperacuity Systems has developed a prototype chip capable of nonlinear increase in resolution or subpixel resolution far beyond either pixel size or spacing. Performance increase is due to a biomimetic implementation of animal retinas. Photosensitivity is not homogeneous across the sensor surface, allowing pixel parsing. It is remarkably simple to provide this profile to detectors and we showed at least three ways to do so. Individual photoreceptors have a Gaussian sensitivity profile and this nonlinear profile can be exploited to extract high-resolution. Adaptive, analog circuitry provides contrast enhancement, dynamic range setting with offset and gain control. Pixels are processed in parallel within modular elements called cartridges like photo-receptor inputs in fly eyes. These modular elements are connected by a novel function for a cell matrix known as L4. The system is exquisitely sensitive to small target motion and operates with a robust signal under degraded viewing conditions, allowing detection of targets smaller than a single pixel or at greater distance. Therefore, not only is instantaneous feature extraction possible but also subpixel resolution. Analog circuitry increases processing speed with more accurate motion specification for target tracking and identification.

A time-accurate high-resolution TVD scheme for solving the Navier-Stokes equations

NASA Technical Reports Server (NTRS)

Kim, Hyun Dae; Liu, Nan-Suey

1992-01-01

A total variation diminishing (TVD) scheme has been developed and incorporated into an existing time-accurate high-resolution Navier-Stokes code. The accuracy and the robustness of the resulting solution procedure have been assessed by performing many calculations in four different areas: shock tube flows, regular shock reflection, supersonic boundary layer, and shock boundary layer interactions. These numerical results compare well with corresponding exact solutions or experimental data.

Space- and time-resolved raman and breakdown spectroscopy: advanced lidar techniques

NASA Astrophysics Data System (ADS)

Silviu, Gurlui; Marius Mihai, Cazacu; Adrian, Timofte; Oana, Rusu; Georgiana, Bulai; Dimitriu, Dan

2018-04-01

DARLIOES - the advanced LIDAR is based on space- and time-resolved RAMAN and breakdown spectroscopy, to investigate chemical and toxic compounds, their kinetics and physical properties at high temporal (2 ns) and spatial (1 cm) resolution. The high spatial and temporal resolution are needed to resolve a large variety of chemical troposphere compounds, emissions from aircraft, the self-organization space charges induced light phenomena, temperature and humidity profiles, ice nucleation, etc.

The 7BM beamline at the APS: a facility for time-resolved fluid dynamics measurements

PubMed Central

Kastengren, Alan; Powell, Christopher F.; Arms, Dohn; Dufresne, Eric M.; Gibson, Harold; Wang, Jin

2012-01-01

In recent years, X-ray radiography has been used to probe the internal structure of dense sprays with microsecond time resolution and a spatial resolution of 15 µm even in high-pressure environments. Recently, the 7BM beamline at the Advanced Photon Source (APS) has been commissioned to focus on the needs of X-ray spray radiography measurements. The spatial resolution and X-ray intensity at this beamline represent a significant improvement over previous time-resolved X-ray radiography measurements at the APS. PMID:22713903

Very high resolution time-lapse photography for plant and ecosystems research

USDA-ARS?s Scientific Manuscript database

Very high resolution gigapixel photography increasingly is being used to support a broad range of ecosystem and physical process research because it offers an inexpensive means of simultaneously collecting information at a range of spatial scales. Recently, methods have been developed to incorporate...

A pulse-front-tilt–compensated streaked optical spectrometer with high throughput and picosecond time resolution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Katz, J., E-mail: jkat@lle.rochester.edu; Boni, R.; Rivlis, R.

A high-throughput, broadband optical spectrometer coupled to the Rochester optical streak system equipped with a Photonis P820 streak tube was designed to record time-resolved spectra with 1-ps time resolution. Spectral resolution of 0.8 nm is achieved over a wavelength coverage range of 480 to 580 nm, using a 300-groove/mm diffraction grating in conjunction with a pair of 225-mm-focal-length doublets operating at an f/2.9 aperture. Overall pulse-front tilt across the beam diameter generated by the diffraction grating is reduced by preferentially delaying discrete segments of the collimated input beam using a 34-element reflective echelon optic. The introduced delay temporally aligns themore » beam segments and the net pulse-front tilt is limited to the accumulation across an individual sub-element. The resulting spectrometer design balances resolving power and pulse-front tilt while maintaining high throughput.« less

Integrating Windblown Dust Forecasts with Public Safety and Health Systems

NASA Astrophysics Data System (ADS)

Sprigg, W. A.

2014-12-01

Experiments in real-time prediction of desert dust emissions and downstream plume concentrations (~ 3.5 km near-surface spatial resolution) succeed to the point of challenging public safety and public health services to beta test a dust storm warning and advisory system in lowering risks of highway and airline accidents and illnesses such as asthma and valley fever. Key beta test components are: high-resolution models of dust emission, entrainment and diffusion, integrated with synoptic weather observations and forecasts; satellite-based detection and monitoring of soil properties on the ground and elevated above; high space and time resolution for health surveillance and transportation advisories.

4D electron microscopy: principles and applications.

PubMed

Flannigan, David J; Zewail, Ahmed H

2012-10-16

The transmission electron microscope (TEM) is a powerful tool enabling the visualization of atoms with length scales smaller than the Bohr radius at a factor of only 20 larger than the relativistic electron wavelength of 2.5 pm at 200 keV. The ability to visualize matter at these scales in a TEM is largely due to the efforts made in correcting for the imperfections in the lens systems which introduce aberrations and ultimately limit the achievable spatial resolution. In addition to the progress made in increasing the spatial resolution, the TEM has become an all-in-one characterization tool. Indeed, most of the properties of a material can be directly mapped in the TEM, including the composition, structure, bonding, morphology, and defects. The scope of applications spans essentially all of the physical sciences and includes biology. Until recently, however, high resolution visualization of structural changes occurring on sub-millisecond time scales was not possible. In order to reach the ultrashort temporal domain within which fundamental atomic motions take place, while simultaneously retaining high spatial resolution, an entirely new approach from that of millisecond-limited TEM cameras had to be conceived. As shown below, the approach is also different from that of nanosecond-limited TEM, whose resolution cannot offer the ultrafast regimes of dynamics. For this reason "ultrafast electron microscopy" is reserved for the field which is concerned with femtosecond to picosecond resolution capability of structural dynamics. In conventional TEMs, electrons are produced by heating a source or by applying a strong extraction field. Both methods result in the stochastic emission of electrons, with no control over temporal spacing or relative arrival time at the specimen. The timing issue can be overcome by exploiting the photoelectric effect and using pulsed lasers to generate precisely timed electron packets of ultrashort duration. The spatial and temporal resolutions achievable with short intense pulses containing a large number of electrons, however, are limited to tens of nanometers and nanoseconds, respectively. This is because Coulomb repulsion is significant in such a pulse, and the electrons spread in space and time, thus limiting the beam coherence. It is therefore not possible to image the ultrafast elementary dynamics of complex transformations. The challenge was to retain the high spatial resolution of a conventional TEM while simultaneously enabling the temporal resolution required to visualize atomic-scale motions. In this Account, we discuss the development of four-dimensional ultrafast electron microscopy (4D UEM) and summarize techniques and applications that illustrate the power of the approach. In UEM, images are obtained either stroboscopically with coherent single-electron packets or with a single electron bunch. Coulomb repulsion is absent under the single-electron condition, thus permitting imaging, diffraction, and spectroscopy, all with high spatiotemporal resolution, the atomic scale (sub-nanometer and femtosecond). The time resolution is limited only by the laser pulse duration and energy carried by the electron packets; the CCD camera has no bearing on the temporal resolution. In the regime of single pulses of electrons, the temporal resolution of picoseconds can be attained when hundreds of electrons are in the bunch. The applications given here are selected to highlight phenomena of different length and time scales, from atomic motions during structural dynamics to phase transitions and nanomechanical oscillations. We conclude with a brief discussion of emerging methods, which include scanning ultrafast electron microscopy (S-UEM), scanning transmission ultrafast electron microscopy (ST-UEM) with convergent beams, and time-resolved imaging of biological structures at ambient conditions with environmental cells.

High spatial resolution imaging for structural health monitoring based on virtual time reversal

NASA Astrophysics Data System (ADS)

Cai, Jian; Shi, Lihua; Yuan, Shenfang; Shao, Zhixue

2011-05-01

Lamb waves are widely used in structural health monitoring (SHM) of plate-like structures. Due to the dispersion effect, Lamb wavepackets will be elongated and the resolution for damage identification will be strongly affected. This effect can be automatically compensated by the time reversal process (TRP). However, the time information of the compensated waves is also removed at the same time. To improve the spatial resolution of Lamb wave detection, virtual time reversal (VTR) is presented in this paper. In VTR, a changing-element excitation and reception mechanism (CERM) rather than the traditional fixed excitation and reception mechanism (FERM) is adopted for time information conservation. Furthermore, the complicated TRP procedure is replaced by simple signal operations which can make savings in the hardware cost for recording and generating the time-reversed Lamb waves. After the effects of VTR for dispersive damage scattered signals are theoretically analyzed, the realization of VTR involving the acquisition of the transfer functions of damage detecting paths under step pulse excitation is discussed. Then, a VTR-based imaging method is developed to improve the spatial resolution of the delay-and-sum imaging with a sparse piezoelectric (PZT) wafer array. Experimental validation indicates that the damage scattered wavepackets of A0 mode in an aluminum plate are partly recompressed and focalized with their time information preserved by VTR. Both the single damage and the dual adjacent damages in the plate can be clearly displayed with high spatial resolution by the proposed VTR-based imaging method.

Max CAPR: high-resolution 3D contrast-enhanced MR angiography with acquisition times under 5 seconds.

PubMed

Haider, Clifton R; Borisch, Eric A; Glockner, James F; Mostardi, Petrice M; Rossman, Phillip J; Young, Phillip M; Riederer, Stephen J

2010-10-01

High temporal and spatial resolution is desired in imaging of vascular abnormalities having short arterial-to-venous transit times. Methods that exploit temporal correlation to reduce the observed frame time demonstrate temporal blurring, obfuscating bolus dynamics. Previously, a Cartesian acquisition with projection reconstruction-like (CAPR) sampling method has been demonstrated for three-dimensional contrast-enhanced angiographic imaging of the lower legs using two-dimensional sensitivity-encoding acceleration and partial Fourier acceleration, providing 1mm isotropic resolution of the calves, with 4.9-sec frame time and 17.6-sec temporal footprint. In this work, the CAPR acquisition is further undersampled to provide a net acceleration approaching 40 by eliminating all view sharing. The tradeoff of frame time and temporal footprint in view sharing is presented and characterized in phantom experiments. It is shown that the resultant 4.9-sec acquisition time, three-dimensional images sets have sufficient spatial and temporal resolution to clearly portray arterial and venous phases of contrast passage. It is further hypothesized that these short temporal footprint sequences provide diagnostic quality images. This is tested and shown in a series of nine contrast-enhanced MR angiography patient studies performed with the new method.

Combining endoscopic ultrasound with Time-Of-Flight PET: The EndoTOFPET-US Project

NASA Astrophysics Data System (ADS)

Frisch, Benjamin

2013-12-01

The EndoTOFPET-US collaboration develops a multimodal imaging technique for endoscopic exams of the pancreas or the prostate. It combines the benefits of high resolution metabolic imaging with Time-Of-Flight Positron Emission Tomography (TOF PET) and anatomical imaging with ultrasound (US). EndoTOFPET-US consists of a PET head extension for a commercial US endoscope and a PET plate outside the body in coincidence with the head. The high level of miniaturization and integration creates challenges in fields such as scintillating crystals, ultra-fast photo-detection, highly integrated electronics, system integration and image reconstruction. Amongst the developments, fast scintillators as well as fast and compact digital SiPMs with single SPAD readout are used to obtain the best coincidence time resolution (CTR). Highly integrated ASICs and DAQ electronics contribute to the timing performances of EndoTOFPET. In view of the targeted resolution of around 1 mm in the reconstructed image, we present a prototype detector system with a CTR better than 240 ps FWHM. We discuss the challenges in simulating such a system and introduce reconstruction algorithms based on graphics processing units (GPU).

Sub-nanosecond time-resolved near-field scanning magneto-optical microscope.

PubMed

Rudge, J; Xu, H; Kolthammer, J; Hong, Y K; Choi, B C

2015-02-01

We report on the development of a new magnetic microscope, time-resolved near-field scanning magneto-optical microscope, which combines a near-field scanning optical microscope and magneto-optical contrast. By taking advantage of the high temporal resolution of time-resolved Kerr microscope and the sub-wavelength spatial resolution of a near-field microscope, we achieved a temporal resolution of ∼50 ps and a spatial resolution of <100 nm. In order to demonstrate the spatiotemporal magnetic imaging capability of this microscope, the magnetic field pulse induced gyrotropic vortex dynamics occurring in 1 μm diameter, 20 nm thick CoFeB circular disks has been investigated. The microscope provides sub-wavelength resolution magnetic images of the gyrotropic motion of the vortex core at a resonance frequency of ∼240 MHz.

Optic for an endoscope/borescope having high resolution and narrow field of view

DOEpatents

Stone, Gary F.; Trebes, James E.

2003-10-28

An optic having optimized high spatial resolution, minimal nonlinear magnification distortion while at the same time having a limited chromatic focal shift or chromatic aberrations. The optic located at the distal end of an endoscopic inspection tool permits a high resolution, narrow field of view image for medical diagnostic applications, compared to conventional optics for endoscopic instruments which provide a wide field of view, low resolution image. The image coverage is over a narrow (<20 degrees) field of view with very low optical distortion (<5% pin cushion or barrel distortion. The optic is also optimized for best color correction as well as to aid medical diagnostics.

Research relative to high resolution camera on the advanced X-ray astrophysics facility

NASA Technical Reports Server (NTRS)

1986-01-01

The HRC (High Resolution Camera) is a photon counting instrument to be flown on the Advanced X-Ray Astrophysics Facility (AXAF). It is a large field of view, high angular resolution, detector for the x-ray telescope. The HRC consists of a CsI coated microchannel plate (MCP) acting as a soft x-ray photocathode, followed by a second MCP for high electronic gain. The MCPs are readout by a crossed grid of resistively coupled wires to provide high spatial resolution along with timing and pulse height data. The instrument will be used in two modes, as a direct imaging detector with a limiting sensitivity of 10 to the -15 ergs sq cm sec in a 10 to the 5th second exposure, and as a readout for an objective transmission grating providing spectral resolution of several hundreds to thousands.

The Advanced Pair Telescope (APT) Mission Concept

NASA Technical Reports Server (NTRS)

Hunter, Stanley; Buckley, James H.

2008-01-01

We present a mission concept for the Advanced Pair Telescope (APT), a high-energy gamma-ray instrument with an order of magnitude improvement in sensitivity, 6 sr field of view, and angular resolution a factor of 3-10 times that of GLAST. With its very wide instantaneous field-of-view and large effective area, this instrument would be capable of detecting GRBs at very large redshifts, would enable a very high resolution study of SNRs and PWN, and could provide hour-scale temporal resolution of transients from many AGN and galactic sources. The APT instrument will consist of a Xe time-projection-chamber tracker that bridges the energy regime between Compton scattering and pair production and will provide an unprecedented improvement in angular resolution; a thick scintillating-fiber trackerlcalorimeter that will provide sensitivity and energy resolution to higher energies and will possess a factor of 10 improvement in geometric factor over GLAST; and an anticoincidence detector using scintillator-tiles to reject charged particles. After the anticipated 10-years of GLAST operation , the APT instrument would provide continued coverage of the critial high-energy gamma-ray band (between 30 MeV to 100 GeV), providing an essential component of broad-band multiwavelength studies of the high-energy universe.

Telepathology. Long-distance diagnosis.

PubMed

Weinstein, R S; Bloom, K J; Rozek, L S

1989-04-01

Telepathology is defined as the practice of pathology at a distance, by visualizing an image on a video monitor rather than viewing a specimen directly through a microscope. Components of a telepathology system include the following: (1) a workstation equipped with a high-resolution video camera attached to a remote-controlled light microscope; (2) a pathologist workstation incorporating controls for manipulating the robotic microscope as well as a high-resolution video monitor; and (3) a telecommunications link. Progress has been made in designing and constructing telepathology workstations and fully motorized, computer-controlled light microscopes suitable for telepathology. In addition, components such as video signal digital encoders and decoders that produce remarkably stable, high-color fidelity, and high-resolution images have been incorporated into the workstations. Resolution requirements for the video microscopy component of telepathology have been formally examined in receiver operator characteristic (ROC) curve analyses. Test-of-concept demonstrations have been completed with the use of geostationary satellites as the broadband communication linkages for 750-line resolution video. Potential benefits of telepathology include providing a means of conveniently delivering pathology services in real-time to remote sites or underserviced areas, time-sharing of pathologists' services by multiple institutions, and increasing accessibility to specialty pathologists.

Rotating single-shot acquisition (RoSA) with composite reconstruction for fast high-resolution diffusion imaging.

PubMed

Wen, Qiuting; Kodiweera, Chandana; Dale, Brian M; Shivraman, Giri; Wu, Yu-Chien

2018-01-01

To accelerate high-resolution diffusion imaging, rotating single-shot acquisition (RoSA) with composite reconstruction is proposed. Acceleration was achieved by acquiring only one rotating single-shot blade per diffusion direction, and high-resolution diffusion-weighted (DW) images were reconstructed by using similarities of neighboring DW images. A parallel imaging technique was implemented in RoSA to further improve the image quality and acquisition speed. RoSA performance was evaluated by simulation and human experiments. A brain tensor phantom was developed to determine an optimal blade size and rotation angle by considering similarity in DW images, off-resonance effects, and k-space coverage. With the optimal parameters, RoSA MR pulse sequence and reconstruction algorithm were developed to acquire human brain data. For comparison, multishot echo planar imaging (EPI) and conventional single-shot EPI sequences were performed with matched scan time, resolution, field of view, and diffusion directions. The simulation indicated an optimal blade size of 48 × 256 and a 30 ° rotation angle. For 1 × 1 mm 2 in-plane resolution, RoSA was 12 times faster than the multishot acquisition with comparable image quality. With the same acquisition time as SS-EPI, RoSA provided superior image quality and minimum geometric distortion. RoSA offers fast, high-quality, high-resolution diffusion images. The composite image reconstruction is model-free and compatible with various diffusion computation approaches including parametric and nonparametric analyses. Magn Reson Med 79:264-275, 2018. © 2017 International Society for Magnetic Resonance in Medicine. © 2017 International Society for Magnetic Resonance in Medicine.

Non-periodic multi-slit masking for a single counter rotating 2-disc chopper and channeling guides for high resolution and high intensity neutron TOF spectroscopy

NASA Astrophysics Data System (ADS)

Bartkowiak, M.; Hofmann, T.; Stüßer, N.

2017-02-01

Energy resolution is an important design goal for time-of-flight instruments and neutron spectroscopy. For high-resolution applications, it is required that the burst times of choppers be short, going down to the μs-range. To produce short pulses while maintaining high neutron flux, we propose beam masks with more than two slits on a counter-rotating 2-disc chopper, behind specially adapted focusing multi-channel guides. A novel non-regular arrangement of the slits ensures that the beam opens only once per chopper cycle, when the masks are congruently aligned. Additionally, beam splitting and intensity focusing by guides before and after the chopper position provide high intensities even for small samples. Phase-space analysis and Monte Carlo simulations on examples of four-slit masks with adapted guide geometries show the potential of the proposed setup.

Up Close and Personal

NASA Image and Video Library

2014-05-08

This image is one of the highest-resolution MDIS observations to date! Many craters of varying degradation states are visible, as well as gentle terrain undulations. Very short exposure times are needed to make these low-altitude observations while the spacecraft is moving quickly over the surface; thus the images are slightly noisier than typical MDIS images. This image was acquired as a high-resolution targeted observation. Targeted observations are images of a small area on Mercury's surface at resolutions much higher than the 200-meter/pixel morphology base map. It is not possible to cover all of Mercury's surface at this high resolution, but typically several areas of high scientific interest are imaged in this mode each week. Date acquired: March 15, 2014 Image Mission Elapsed Time (MET): 37173522 Image ID: 5936740 Instrument: Narrow Angle Camera (NAC) of the Mercury Dual Imaging System (MDIS) Center Latitude: 71.91° Center Longitude: 232.7° E Resolution: 5 meters/pixel Scale: The image is approximately 8.3 km (5.2 mi.) across. Incidence Angle: 79.4° Emission Angle: 4.0° Phase Angle: 83.4° http://photojournal.jpl.nasa.gov/catalog/PIA18370

Comparison of mosaicking techniques for airborne images from consumer-grade cameras

USDA-ARS?s Scientific Manuscript database

Images captured from airborne imaging systems have the advantages of relatively low cost, high spatial resolution, and real/near-real-time availability. Multiple images taken from one or more flight lines could be used to generate a high-resolution mosaic image, which could be useful for diverse rem...

Low-cost camera modifications and methodologies for very-high-resolution digital images

USDA-ARS?s Scientific Manuscript database

Aerial color and color-infrared photography are usually acquired at high altitude so the ground resolution of the photographs is < 1 m. Moreover, current color-infrared cameras and manned aircraft flight time are expensive, so the objective is the development of alternative methods for obtaining ve...

High-Resolution Mesoscale Simulations of the 6-7 May 2000 Missouri Flash Flood: Impact of Model Initialization and Land Surface Treatment

NASA Technical Reports Server (NTRS)

Baker, R. David; Wang, Yansen; Tao, Wei-Kuo; Wetzel, Peter; Belcher, Larry R.

2004-01-01

High-resolution mesoscale model simulations of the 6-7 May 2000 Missouri flash flood event were performed to test the impact of model initialization and land surface treatment on timing, intensity, and location of extreme precipitation. In this flash flood event, a mesoscale convective system (MCS) produced over 340 mm of rain in roughly 9 hours in some locations. Two different types of model initialization were employed: 1) NCEP global reanalysis with 2.5-degree grid spacing and 12-hour temporal resolution, and 2) Eta reanalysis with 40- km grid spacing and $hour temporal resolution. In addition, two different land surface treatments were considered. A simple land scheme. (SLAB) keeps soil moisture fixed at initial values throughout the simulation, while a more sophisticated land model (PLACE) allows for r interactive feedback. Simulations with high-resolution Eta model initialization show considerable improvement in the intensity of precipitation due to the presence in the initialization of a residual mesoscale convective vortex (hlCV) from a previous MCS. Simulations with the PLACE land model show improved location of heavy precipitation. Since soil moisture can vary over time in the PLACE model, surface energy fluxes exhibit strong spatial gradients. These surface energy flux gradients help produce a strong low-level jet (LLJ) in the correct location. The LLJ then interacts with the cold outflow boundary of the MCS to produce new convective cells. The simulation with both high-resolution model initialization and time-varying soil moisture test reproduces the intensity and location of observed rainfall.

Assessing the quality of rainfall data when aiming to achieve flood resilience

NASA Astrophysics Data System (ADS)

Hoang, C. T.; Tchiguirinskaia, I.; Schertzer, D.; Lovejoy, S.

2012-04-01

A new EU Floods Directive entered into force five years ago. This Directive requires Member States to coordinate adequate measures to reduce flood risk. European flood management systems require reliable rainfall statistics, e.g. the Intensity-duration-Frequency curves for shorter and shorter durations and for a larger and larger range of return periods. Preliminary studies showed that the number of floods was lower when using low time resolution data of high intensity rainfall events, compared to estimates obtained with the help of higher time resolution data. These facts suggest that a particular attention should be paid to the rainfall data quality in order to adequately investigate flood risk aiming to achieve flood resilience. The potential consequences of changes in measuring and recording techniques have been somewhat discussed in the literature with respect to a possible introduction of artificial inhomogeneities in time series. In this paper, we discuss how to detect another artificiality: most of the rainfall time series have a lower recording frequency than that is assumed, furthermore the effective high-frequency limit often depends on the recording year due to algorithm changes. This question is particularly important for operational hydrology, because an error on the effective recording high frequency introduces biases in the corresponding statistics. In this direction, we developed a first version of a SERQUAL procedure to automatically detect the effective time resolution of highly mixed data. Being applied to the 166 rainfall time series in France, the SERQUAL procedure has detected that most of them have an effective hourly resolution, rather than a 5 minutes resolution. Furthermore, series having an overall 5 minute resolution do not have it for all years. These results raise serious concerns on how to benchmark stochastic rainfall models at a sub-hourly resolution, which are particularly desirable for operational hydrology. Therefore, database quality must be checked before use. Due to the fact that the multiple scales and possible scaling behaviour of hydrological data are particularly important for many applications, including flood resilience research, this paper first investigates the sensitivity of the scaling estimates and methods to the deficit of short duration rainfall data, and consequently propose a few simple criteria for a reliable evaluation of the data quality. Then we showed that our procedure SERQUAL enable us to extract high quality sub-series from longer time series that will be much more reliable to calibrate and/or validate short duration quantiles and hydrological models.

High Resolution PET Imaging Probe for the Detection, Molecular Characterization and Treatment Monitoring of Prostate Cancer

DTIC Science & Technology

2012-07-01

Jitter results from electronic noise and from the fact that the shape of the detector signal used for timing can vary considerably depending on the...photomultiplier technology, several “probe” detectors were developed. It was predicted, and subsequently shown, that probes having good position...high spatial resolution for prostate imaging. Practical proof-of-concept detectors with good depth-of-interactions resolution have been developed and

GLAST Burst Monitor Signal Processing System

NASA Astrophysics Data System (ADS)

Bhat, P. Narayana; Briggs, Michael; Connaughton, Valerie; Diehl, Roland; Fishman, Gerald; Greiner, Jochen; Kippen, R. Marc; von Kienlin, Andreas; Kouveliotou, Chryssa; Lichti, Giselher; Meegan, Charles; Paciesas, William; Persyn, Steven; Preece, Robert; Steinle, Helmut; Wilson-Hodge, Colleen

2007-07-01

The onboard Data Processing Unit (DPU), designed and built by Southwest Research Institute, performs the high-speed data acquisition for GBM. The analog signals from each of the 14 detectors are digitized by high-speed multichannel analog data acquisition architecture. The streaming digital values resulting from a periodic (period of 104.2 ns) sampling of the analog signal by the individual ADCs are fed to a Field-Programmable Gate Array (FPGA). Real-time Digital Signal Processing (DSP) algorithms within the FPGA implement functions like filtering, thresholding, time delay and pulse height measurement. The spectral data with a 12-bit resolution are formatted according to the commandable look-up-table (LUT) and then sent to the High-Speed Science-Date Bus (HSSDB, speed=1.5 MB/s) to be telemetered to ground. The DSP offers a novel feature of a commandable & constant event deadtime. The ADC non-linearities have been calibrated so that the spectral data can be corrected during analysis. The best temporal resolution is 2 μs for the pre-burst & post-trigger time-tagged events (TTE) data. The time resolution of the binned data types is commandable from 64 msec to 1.024 s for the CTIME data (8 channel spectral resolution) and 1.024 to 32.768 s for the CSPEC data (128 channel spectral resolution). The pulse pile-up effects have been studied by Monte Carlo simulations. For a typical GRB, the possible shift in the Epeak value at high-count rates (~100 kHz) is ~1% while the change in the single power-law index could be up to 5%.

A multi-temporal analysis approach for land cover mapping in support of nuclear incident response

NASA Astrophysics Data System (ADS)

Sah, Shagan; van Aardt, Jan A. N.; McKeown, Donald M.; Messinger, David W.

2012-06-01

Remote sensing can be used to rapidly generate land use maps for assisting emergency response personnel with resource deployment decisions and impact assessments. In this study we focus on constructing accurate land cover maps to map the impacted area in the case of a nuclear material release. The proposed methodology involves integration of results from two different approaches to increase classification accuracy. The data used included RapidEye scenes over Nine Mile Point Nuclear Power Station (Oswego, NY). The first step was building a coarse-scale land cover map from freely available, high temporal resolution, MODIS data using a time-series approach. In the case of a nuclear accident, high spatial resolution commercial satellites such as RapidEye or IKONOS can acquire images of the affected area. Land use maps from the two image sources were integrated using a probability-based approach. Classification results were obtained for four land classes - forest, urban, water and vegetation - using Euclidean and Mahalanobis distances as metrics. Despite the coarse resolution of MODIS pixels, acceptable accuracies were obtained using time series features. The overall accuracies using the fusion based approach were in the neighborhood of 80%, when compared with GIS data sets from New York State. The classifications were augmented using this fused approach, with few supplementary advantages such as correction for cloud cover and independence from time of year. We concluded that this method would generate highly accurate land maps, using coarse spatial resolution time series satellite imagery and a single date, high spatial resolution, multi-spectral image.

THOR Ion Mass Spectrometer instrument - IMS

NASA Astrophysics Data System (ADS)

Retinò, Alessandro; Kucharek, Harald; Saito, Yoshifumi; Fraenz, Markus; Verdeil, Christophe; Leblanc, Frederic; Techer, Jean-Denis; Jeandet, Alexis; Macri, John; Gaidos, John; Granoff, Mark; Yokota, Shoichiro; Fontaine, Dominique; Berthomier, Matthieu; Delcourt, Dominique; Kistler, Lynn; Galvin, Antoniette; Kasahara, Satoshi; Kronberg, Elena

2016-04-01

Turbulence Heating ObserveR (THOR) is the first mission ever flown in space dedicated to plasma turbulence. Specifically, THOR will study how turbulent fluctuations at kinetic scales heat and accelerate particles in different turbulent environments within the near-Earth space. To achieve this goal, THOR payload is being designed to measure electromagnetic fields and particle distribution functions with unprecedented resolution and accuracy. Here we present the Ion Mass Spectrometer (IMS) instrument that will measure the full three-dimensional distribution functions of near-Earth main ion species (H+, He+, He++ and O+) at high time resolution (~ 150 ms for H+ , ~ 300 ms for He++) with energy resolution down to ~ 10% in the range 10 eV/q to 30 keV/q and angular resolution ~ 10°. Such high time resolution is achieved by mounting multiple sensors around the spacecraft body, in similar fashion to the MMS/FPI instrument. Each sensor combines a top-hat electrostatic analyzer with deflectors at the entrance together with a time-of-flight section to perform mass selection. IMS electronics includes a fast sweeping high voltage board that is required to make measurements at high cadence. Ion detection includes Micro Channel Plates (MCP) combined with Application-Specific Integrated Circuits (ASICs) for charge amplification, discrimination and time-to-digital conversion (TDC). IMS is being designed to address many of THOR science requirements, in particular ion heating and acceleration by turbulent fluctuations in foreshock, shock and magnetosheath regions. The IMS instrument is being designed and will be built by an international consortium of scientific institutes with main hardware contributions from France, USA, Japan and Germany.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Foxley, Sean, E-mail: sean.foxley@ndcn.ox.ac.uk; Karczmar, Gregory S.; Domowicz, Miriam

Purpose: Widely used MRI methods show brain morphology both in vivo and ex vivo at very high resolution. Many of these methods (e.g., T{sub 2}{sup *}-weighted imaging, phase-sensitive imaging, or susceptibility-weighted imaging) are sensitive to local magnetic susceptibility gradients produced by subtle variations in tissue composition. However, the spectral resolution of commonly used methods is limited to maintain reasonable run-time combined with very high spatial resolution. Here, the authors report on data acquisition at increased spectral resolution, with 3-dimensional high spectral and spatial resolution MRI, in order to analyze subtle variations in water proton resonance frequency and lineshape that reflectmore » local anatomy. The resulting information compliments previous studies based on T{sub 2}{sup *} and resonance frequency. Methods: The proton free induction decay was sampled at high resolution and Fourier transformed to produce a high-resolution water spectrum for each image voxel in a 3D volume. Data were acquired using a multigradient echo pulse sequence (i.e., echo-planar spectroscopic imaging) with a spatial resolution of 50 × 50 × 70 μm{sup 3} and spectral resolution of 3.5 Hz. Data were analyzed in the spectral domain, and images were produced from the various Fourier components of the water resonance. This allowed precise measurement of local variations in water resonance frequency and lineshape, at the expense of significantly increased run time (16–24 h). Results: High contrast T{sub 2}{sup *}-weighted images were produced from the peak of the water resonance (peak height image), revealing a high degree of anatomical detail, specifically in the hippocampus and cerebellum. In images produced from Fourier components of the water resonance at −7.0 Hz from the peak, the contrast between deep white matter tracts and the surrounding tissue is the reverse of the contrast in water peak height images. This indicates the presence of a shoulder in the water resonance that is not present at +7.0 Hz and may be specific to white matter anatomy. Moreover, a frequency shift of 6.76 ± 0.55 Hz was measured between the molecular and granular layers of the cerebellum. This shift is demonstrated in corresponding spectra; water peaks from voxels in the molecular and granular layers are consistently 2 bins apart (7.0 Hz, as dictated by the spectral resolution) from one another. Conclusions: High spectral and spatial resolution MR imaging has the potential to accurately measure the changes in the water resonance in small voxels. This information can guide optimization and interpretation of more commonly used, more rapid imaging methods that depend on image contrast produced by local susceptibility gradients. In addition, with improved sampling methods, high spectral and spatial resolution data could be acquired in reasonable run times, and used for in vivo scans to increase sensitivity to variations in local susceptibility.« less

High resolution gamma-ray spectroscopy at high count rates with a prototype High Purity Germanium detector

NASA Astrophysics Data System (ADS)

Cooper, R. J.; Amman, M.; Vetter, K.

2018-04-01

High-resolution gamma-ray spectrometers are required for applications in nuclear safeguards, emergency response, and fundamental nuclear physics. To overcome one of the shortcomings of conventional High Purity Germanium (HPGe) detectors, we have developed a prototype device capable of achieving high event throughput and high energy resolution at very high count rates. This device, the design of which we have previously reported on, features a planar HPGe crystal with a reduced-capacitance strip electrode geometry. This design is intended to provide good energy resolution at the short shaping or digital filter times that are required for high rate operation and which are enabled by the fast charge collection afforded by the planar geometry crystal. In this work, we report on the initial performance of the system at count rates up to and including two million counts per second.

Imaging performance of a LaBr3-based PET scanner

PubMed Central

Daube-Witherspoon, M E; Surti, S; Perkins, A; Kyba, C C M; Wiener, R; Werner, M E; Kulp, R; Karp, J S

2010-01-01

A prototype time-of-flight (TOF) PET scanner based on cerium-doped lanthanum bromide [LaBr3 (5% Ce)] has been developed. LaBr3 has high light output, excellent energy resolution, and fast timing properties that have been predicted to lead to good image quality. Intrinsic performance measurements of spatial resolution, sensitivity, and scatter fraction demonstrate good conventional PET performance; the results agree with previous simulation studies. Phantom measurements show the excellent image quality achievable with the prototype system. Phantom measurements and corresponding simulations show a faster and more uniform convergence rate, as well as more uniform quantification, for TOF reconstruction of the data, which have 375-ps intrinsic timing resolution, compared to non-TOF images. Measurements and simulations of a hot and cold sphere phantom show that the 7% energy resolution helps to mitigate residual errors in the scatter estimate because a high energy threshold (>480 keV) can be used to restrict the amount of scatter accepted without a loss of true events. Preliminary results with incorporation of a model of detector blurring in the iterative reconstruction algorithm show improved contrast recovery but also point out the importance of an accurate resolution model of the tails of LaBr3’s point spread function. The LaBr3 TOF-PET scanner has demonstrated the impact of superior timing and energy resolutions on image quality. PMID:19949259

Estimating Soil Moisture at High Spatial Resolution with Three Radiometric Satellite Products: A Study from a South-Eastern Australian Catchment

NASA Astrophysics Data System (ADS)

Senanayake, I. P.; Yeo, I. Y.; Tangdamrongsub, N.; Willgoose, G. R.; Hancock, G. R.; Wells, T.; Fang, B.; Lakshmi, V.

2017-12-01

Long-term soil moisture datasets at high spatial resolution are important in agricultural, hydrological, and climatic applications. The soil moisture estimates can be achieved using satellite remote sensing observations. However, the satellite soil moisture data are typically available at coarse spatial resolutions ( several tens of km), therefore require further downscaling. Different satellite soil moisture products have to be conjointly employed in developing a consistent time-series of high resolution soil moisture, while the discrepancies amongst different satellite retrievals need to be resolved. This study aims to downscale three different satellite soil moisture products, the Soil Moisture and Ocean Salinity (SMOS, 25 km), the Soil Moisture Active Passive (SMAP, 36 km) and the SMAP-Enhanced (9 km), and to conduct an inter-comparison of the downscaled results. The downscaling approach is developed based on the relationship between the diurnal temperature difference and the daily mean soil moisture content. The approach is applied to two sub-catchments (Krui and Merriwa River) of the Goulburn River catchment in the Upper Hunter region (NSW, Australia) to estimate soil moisture at 1 km resolution for 2015. The three coarse spatial resolution soil moisture products and their downscaled results will be validated with the in-situ observations obtained from the Scaling and Assimilation of Soil Moisture and Streamflow (SASMAS) network. The spatial and temporal patterns of the downscaled results will also be analysed. This study will provide the necessary insights for data selection and bias corrections to maintain the consistency of a long-term high resolution soil moisture dataset. The results will assist in developing a time-series of high resolution soil moisture data over the south-eastern Australia.

Ultra high resolution imaging of the human head at 8 tesla: 2K x 2K for Y2K.

PubMed

Robitaille, P M; Abduljalil, A M; Kangarlu, A

2000-01-01

To acquire ultra high resolution MRI images of the human brain at 8 Tesla within a clinically acceptable time frame. Gradient echo images were acquired from the human head of normal subjects using a transverse electromagnetic resonator operating in quadrature and tuned to 340 MHz. In each study, a group of six images was obtained containing a total of 208 MB of unprocessed information. Typical acquisition parameters were as follows: matrix = 2,000 x 2,000, field of view = 20 cm, slice thickness = 2 mm, number of excitations (NEX) = 1, flip angle = 45 degrees, TR = 750 ms, TE = 17 ms, receiver bandwidth = 69.4 kHz. This resulted in a total scan time of 23 minutes, an in-plane resolution of 100 microm, and a pixel volume of 0.02 mm3. The ultra high resolution images acquired in this study represent more than a 50-fold increase in in-plane resolution relative to conventional 256 x 256 images obtained with a 20 cm field of view and a 5 mm slice thickness. Nonetheless, the ultra high resolution images could be acquired both with adequate image quality and signal to noise. They revealed numerous small venous structures throughout the image plane and provided reasonable delineation between gray and white matter. The elevated signal-to-noise ratio observed in ultra high field magnetic resonance imaging can be utilized to acquire images with a level of resolution approaching the histological level under in vivo conditions. However, brain motion is likely to degrade the useful resolution. This situation may be remedied in part with cardiac gating. Nonetheless, these images represent a significant advance in our ability to examine small anatomical features with noninvasive imaging methods.

Development of a spatio-temporal disaggregation method (DisNDVI) for generating a time series of fine resolution NDVI images

NASA Astrophysics Data System (ADS)

Bindhu, V. M.; Narasimhan, B.

2015-03-01

Normalized Difference Vegetation Index (NDVI), a key parameter in understanding the vegetation dynamics, has high spatial and temporal variability. However, continuous monitoring of NDVI is not feasible at fine spatial resolution (<60 m) owing to the long revisit time needed by the satellites to acquire the fine spatial resolution data. Further, the study attains significance in the case of humid tropical regions of the earth, where the prevailing atmospheric conditions restrict availability of fine resolution cloud free images at a high temporal frequency. As an alternative to the lack of high resolution images, the current study demonstrates a novel disaggregation method (DisNDVI) which integrates the spatial information from a single fine resolution image and temporal information in terms of crop phenology from time series of coarse resolution images to generate estimates of NDVI at fine spatial and temporal resolution. The phenological variation of the pixels captured at the coarser scale provides the basis for relating the temporal variability of the pixel with the NDVI available at fine resolution. The proposed methodology was tested over a 30 km × 25 km spatially heterogeneous study area located in the south of Tamil Nadu, India. The robustness of the algorithm was assessed by an independent comparison of the disaggregated NDVI and observed NDVI obtained from concurrent Landsat ETM+ imagery. The results showed good spatial agreement across the study area dominated with agriculture and forest pixels, with a root mean square error of 0.05. The validation done at the coarser scale showed that disaggregated NDVI spatially averaged to 240 m compared well with concurrent MODIS NDVI at 240 m (R2 > 0.8). The validation results demonstrate the effectiveness of DisNDVI in improving the spatial and temporal resolution of NDVI images for utility in fine scale hydrological applications such as crop growth monitoring and estimation of evapotranspiration.

High-resolution time series of Pseudomonas aeruginosa gene expression and rhamnolipid secretion through growth curve synchronization.

PubMed

van Ditmarsch, Dave; Xavier, João B

2011-06-17

Online spectrophotometric measurements allow monitoring dynamic biological processes with high-time resolution. Contrastingly, numerous other methods require laborious treatment of samples and can only be carried out offline. Integrating both types of measurement would allow analyzing biological processes more comprehensively. A typical example of this problem is acquiring quantitative data on rhamnolipid secretion by the opportunistic pathogen Pseudomonas aeruginosa. P. aeruginosa cell growth can be measured by optical density (OD600) and gene expression can be measured using reporter fusions with a fluorescent protein, allowing high time resolution monitoring. However, measuring the secreted rhamnolipid biosurfactants requires laborious sample processing, which makes this an offline measurement. Here, we propose a method to integrate growth curve data with endpoint measurements of secreted metabolites that is inspired by a model of exponential cell growth. If serial diluting an inoculum gives reproducible time series shifted in time, then time series of endpoint measurements can be reconstructed using calculated time shifts between dilutions. We illustrate the method using measured rhamnolipid secretion by P. aeruginosa as endpoint measurements and we integrate these measurements with high-resolution growth curves measured by OD600 and expression of rhamnolipid synthesis genes monitored using a reporter fusion. Two-fold serial dilution allowed integrating rhamnolipid measurements at a ~0.4 h-1 frequency with high-time resolved data measured at a 6 h-1 frequency. We show how this simple method can be used in combination with mutants lacking specific genes in the rhamnolipid synthesis or quorum sensing regulation to acquire rich dynamic data on P. aeruginosa virulence regulation. Additionally, the linear relation between the ratio of inocula and the time-shift between curves produces high-precision measurements of maximum specific growth rates, which were determined with a precision of ~5.4%. Growth curve synchronization allows integration of rich time-resolved data with endpoint measurements to produce time-resolved quantitative measurements. Such data can be valuable to unveil the dynamic regulation of virulence in P. aeruginosa. More generally, growth curve synchronization can be applied to many biological systems thus helping to overcome a key obstacle in dynamic regulation: the scarceness of quantitative time-resolved data.

High resolution present climate and surface mass balance (SMB) of Svalbard modelled by MAR and implementation of a new online SMB downscaling method

NASA Astrophysics Data System (ADS)

Lang, C.; Fettweis, X.; Kittel, C.; Erpicum, M.

2017-12-01

We present the results of high resolution simulations of the climate and SMB of Svalbard with the regional climate model MAR forced by ERA-40 then ERA-Interim, as well as an online downscaling method allowing us to model the SMB and its components at a resolution twice as high (2.5 vs 5 km here) using only about 25% more CPU time. Spitsbergen, the largest island in Svalbard, has a very hilly topography and a high spatial resolution is needed to correctly represent the local topography and the complex pattern of ice distribution and precipitation. However, high resolution runs with an RCM fully coupled to an energy balance module like MAR require a huge amount of computation time. The hydrostatic equilibrium hypothesis used in MAR also becomes less valid as the spatial resolution increases. We therefore developed in MAR a method to run the snow module at a resolution twice as high as the atmospheric module. Near-surface temperature and humidity are corrected on a grid with a resolution twice as high, as a function of their local gradients and the elevation difference between the corresponding pixels in the 2 grids. We compared the results of our runs at 5 km and with SMB downscaled at 2.5 km over 1960 — 2016 and compared those to previous 10 km runs. On Austfonna, where the slopes are gentle, the agreement between observations and the 5 km SMB is better than with the 10 km SMB. It is again improved at 2.5 km but the gain is relatively small, showing the interest of our method rather than running a time consuming classic 2.5 km resolution simulation. On Spitsbergen, we show that a spatial resolution of 2.5 km is still not enough to represent the complex pattern of topography, precipitation and SMB. Due to a change in the summer atmospheric circulation, from a westerly flow over Svalbard to a northwesterly flow bringing colder air, the SMB of Svalbard was stable between 2006 and 2012, while several melt records were broken in Greenland, due to conditions more anticyclonic than usual. In 2013, the reverse situation happened and a southwesterly atmospheric circulation brought warmer air over Svalbard. The SMB broke the last 55 years' record. In 2016, the temperature was higher than average and a new record melt was broken despite a northwesterly flow. The northerly flow still mitigated the warming over Svalbard, which was much lower than most regions of the Arctic.

Acceleration of high resolution temperature based optimization for hyperthermia treatment planning using element grouping.

PubMed

Kok, H P; de Greef, M; Bel, A; Crezee, J

2009-08-01

In regional hyperthermia, optimization is useful to obtain adequate applicator settings. A speed-up of the previously published method for high resolution temperature based optimization is proposed. Element grouping as described in literature uses selected voxel sets instead of single voxels to reduce computation time. Elements which achieve their maximum heating potential for approximately the same phase/amplitude setting are grouped. To form groups, eigenvalues and eigenvectors of precomputed temperature matrices are used. At high resolution temperature matrices are unknown and temperatures are estimated using low resolution (1 cm) computations and the high resolution (2 mm) temperature distribution computed for low resolution optimized settings using zooming. This technique can be applied to estimate an upper bound for high resolution eigenvalues. The heating potential of elements was estimated using these upper bounds. Correlations between elements were estimated with low resolution eigenvalues and eigenvectors, since high resolution eigenvectors remain unknown. Four different grouping criteria were applied. Constraints were set to the average group temperatures. Element grouping was applied for five patients and optimal settings for the AMC-8 system were determined. Without element grouping the average computation times for five and ten runs were 7.1 and 14.4 h, respectively. Strict grouping criteria were necessary to prevent an unacceptable exceeding of the normal tissue constraints (up to approximately 2 degrees C), caused by constraining average instead of maximum temperatures. When strict criteria were applied, speed-up factors of 1.8-2.1 and 2.6-3.5 were achieved for five and ten runs, respectively, depending on the grouping criteria. When many runs are performed, the speed-up factor will converge to 4.3-8.5, which is the average reduction factor of the constraints and depends on the grouping criteria. Tumor temperatures were comparable. Maximum exceeding of the constraint in a hot spot was 0.24-0.34 degree C; average maximum exceeding over all five patients was 0.09-0.21 degree C, which is acceptable. High resolution temperature based optimization using element grouping can achieve a speed-up factor of 4-8, without large deviations from the conventional method.

High-resolution ultrasound imaging and noninvasive optoacoustic monitoring of blood variables in peripheral blood vessels

NASA Astrophysics Data System (ADS)

Petrov, Irene Y.; Petrov, Yuriy; Prough, Donald S.; Esenaliev, Rinat O.

2011-03-01

Ultrasound imaging is being widely used in clinics to obtain diagnostic information non-invasively and in real time. A high-resolution ultrasound imaging platform, Vevo (VisualSonics, Inc.) provides in vivo, real-time images with exceptional resolution (up to 30 microns) using high-frequency transducers (up to 80 MHz). Recently, we built optoacoustic systems for probing radial artery and peripheral veins that can be used for noninvasive monitoring of total hemoglobin concentration, oxyhemoglobin saturation, and concentration of important endogenous and exogenous chromophores (such as ICG). In this work we used the high-resolution ultrasound imaging system Vevo 770 for visualization of the radial artery and peripheral veins and acquired corresponding optoacoustic signals from them using the optoacoustic systems. Analysis of the optoacoustic data with a specially developed algorithm allowed for measurement of blood oxygenation in the blood vessels as well as for continuous, real-time monitoring of arterial and venous blood oxygenation. Our results indicate that: 1) the optoacoustic technique (unlike pure optical approaches and other noninvasive techniques) is capable of accurate peripheral venous oxygenation measurement; and 2) peripheral venous oxygenation is dependent on skin temperature and local hemodynamics. Moreover, we performed for the first time (to the best of our knowledge) a comparative study of optoacoustic arterial oximetry and a standard pulse oximeter in humans and demonstrated superior performance of the optoacoustic arterial oximeter, in particular at low blood flow.

A compact high resolution flat panel PET detector based on the new 4-side buttable MPPC for biomedical applications.

PubMed

Wang, Qiang; Wen, Jie; Ravindranath, Bosky; O'Sullivan, Andrew W; Catherall, David; Li, Ke; Wei, Shouyi; Komarov, Sergey; Tai, Yuan-Chuan

2015-09-11

Compact high-resolution panel detectors using virtual pinhole (VP) PET geometry can be inserted into existing clinical or pre-clinical PET systems to improve regional spatial resolution and sensitivity. Here we describe a compact panel PET detector built using the new Though Silicon Via (TSV) multi-pixel photon counters (MPPC) detector. This insert provides high spatial resolution and good timing performance for multiple bio-medical applications. Because the TSV MPPC design eliminates wire bonding and has a package dimension which is very close to the MPPC's active area, it is 4-side buttable. The custom designed MPPC array (based on Hamamatsu S12641-PA-50(x)) used in the prototype is composed of 4 × 4 TSV-MPPC cells with a 4.46 mm pitch in both directions. The detector module has 16 × 16 lutetium yttrium oxyorthosilicate (LYSO) crystal array, with each crystal measuring 0.92 × 0.92 × 3 mm 3 with 1.0 mm pitch. The outer diameter of the detector block is 16.8 × 16.8 mm 2 . Thirty-two such blocks will be arranged in a 4 × 8 array with 1 mm gaps to form a panel detector with detection area around 7 cm × 14 cm in the full-size detector. The flood histogram acquired with Ge-68 source showed excellent crystal separation capability with all 256 crystals clearly resolved. The detector module's mean, standard deviation, minimum (best) and maximum (worst) energy resolution were 10.19%, +/-0.68%, 8.36% and 13.45% FWHM, respectively. The measured coincidence time resolution between the block detector and a fast reference detector (around 200 ps single photon timing resolution) was 0.95 ns. When tested with Siemens Cardinal electronics the performance of the detector blocks remain consistent. These results demonstrate that the TSV-MPPC is a promising photon sensor for use in a flat panel PET insert composed of many high resolution compact detector modules.

Image Quality in High-resolution and High-cadence Solar Imaging

NASA Astrophysics Data System (ADS)

Denker, C.; Dineva, E.; Balthasar, H.; Verma, M.; Kuckein, C.; Diercke, A.; González Manrique, S. J.

2018-03-01

Broad-band imaging and even imaging with a moderate bandpass (about 1 nm) provides a photon-rich environment, where frame selection (lucky imaging) becomes a helpful tool in image restoration, allowing us to perform a cost-benefit analysis on how to design observing sequences for imaging with high spatial resolution in combination with real-time correction provided by an adaptive optics (AO) system. This study presents high-cadence (160 Hz) G-band and blue continuum image sequences obtained with the High-resolution Fast Imager (HiFI) at the 1.5-meter GREGOR solar telescope, where the speckle-masking technique is used to restore images with nearly diffraction-limited resolution. The HiFI employs two synchronized large-format and high-cadence sCMOS detectors. The median filter gradient similarity (MFGS) image-quality metric is applied, among others, to AO-corrected image sequences of a pore and a small sunspot observed on 2017 June 4 and 5. A small region of interest, which was selected for fast-imaging performance, covered these contrast-rich features and their neighborhood, which were part of Active Region NOAA 12661. Modifications of the MFGS algorithm uncover the field- and structure-dependency of this image-quality metric. However, MFGS still remains a good choice for determining image quality without a priori knowledge, which is an important characteristic when classifying the huge number of high-resolution images contained in data archives. In addition, this investigation demonstrates that a fast cadence and millisecond exposure times are still insufficient to reach the coherence time of daytime seeing. Nonetheless, the analysis shows that data acquisition rates exceeding 50 Hz are required to capture a substantial fraction of the best seeing moments, significantly boosting the performance of post-facto image restoration.

MR-based source localization for MR-guided HDR brachytherapy

NASA Astrophysics Data System (ADS)

Beld, E.; Moerland, M. A.; Zijlstra, F.; Viergever, M. A.; Lagendijk, J. J. W.; Seevinck, P. R.

2018-04-01

For the purpose of MR-guided high-dose-rate (HDR) brachytherapy, a method for real-time localization of an HDR brachytherapy source was developed, which requires high spatial and temporal resolutions. MR-based localization of an HDR source serves two main aims. First, it enables real-time treatment verification by determination of the HDR source positions during treatment. Second, when using a dummy source, MR-based source localization provides an automatic detection of the source dwell positions after catheter insertion, allowing elimination of the catheter reconstruction procedure. Localization of the HDR source was conducted by simulation of the MR artifacts, followed by a phase correlation localization algorithm applied to the MR images and the simulated images, to determine the position of the HDR source in the MR images. To increase the temporal resolution of the MR acquisition, the spatial resolution was decreased, and a subpixel localization operation was introduced. Furthermore, parallel imaging (sensitivity encoding) was applied to further decrease the MR scan time. The localization method was validated by a comparison with CT, and the accuracy and precision were investigated. The results demonstrated that the described method could be used to determine the HDR source position with a high accuracy (0.4–0.6 mm) and a high precision (⩽0.1 mm), at high temporal resolutions (0.15–1.2 s per slice). This would enable real-time treatment verification as well as an automatic detection of the source dwell positions.

Shot-noise-limited monitoring and phase locking of the motion of a single trapped ion.

PubMed

Bushev, P; Hétet, G; Slodička, L; Rotter, D; Wilson, M A; Schmidt-Kaler, F; Eschner, J; Blatt, R

2013-03-29

We perform a high-resolution real-time readout of the motion of a single trapped and laser-cooled Ba+ ion. By using an interferometric setup, we demonstrate a shot-noise-limited measurement of thermal oscillations with a resolution of 4 times the standard quantum limit. We apply the real-time monitoring for phase control of the ion motion through a feedback loop, suppressing the photon recoil-induced phase diffusion. Because of the spectral narrowing in the phase-locked mode, the coherent ion oscillation is measured with a resolution of about 0.3 times the standard quantum limit.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barbosa, F.; Somov, A. S.; Somov, S. V.

Here, silicon photomultipliers (SiPMs) are used in detectors of the GlueX experiment devoted to studying the nature of confinement. These detectors are operable at counting rates as high as 2 MHz with a time resolution (FWHM) of approximately 0.3 ns and a number of excited pixels of up to 10 4. For SiPMs that operate under these conditions, the measured dependences of the recovery time and the time resolution are presented as functions of the number of excited pixels and the excitation frequency. Using a picosecond laser, the time resolution has been measured for an array of 4 × 4more » SiPMs, which was specially developed for the experiment.« less

A Paired Comparison of Initial and Recurrent Concussions Sustained by US High School Athletes Within a Single Athletic Season.

PubMed

Currie, Dustin W; Comstock, R Dawn; Fields, Sarah K; Cantu, Robert C

To compare initial and recurrent concussions regarding average number of days between concussions, acute concussion symptoms and symptom resolution time, and return to play time. High school athletes sustaining multiple concussions linked within sport seasons drawn from a large sports injury surveillance study. Retrospective analysis of longitudinal surveillance data. Number of days between concussions, number of symptoms endorsed, specific symptoms endorsed, symptom resolution time, return to play time. Median time between initial and recurrent concussions was 21 days (interquartile range = 10-43 days). Loss of consciousness, the only significant symptom difference, occurred more frequently in recurrent (6.8%) than initial (1.7%) concussions (P = .04). No significant difference was found in the number of symptoms (P = .84) or symptom resolution time (P = .74). Recurrent concussions kept athletes from play longer than initial concussions (P < .0001); 26.6% of recurrent concussions were season ending. We found that athletes' initial and recurrent concussions had similar symptom presentations and resolution time. Despite these similarities, athletes were restricted from returning to play for longer periods following a recurrent concussion, indicating clinicians are managing recurrent concussions more conservatively. It is probable that concussion recognition and management are superior now compared with when previous studies were published, possibly improving recurrent concussion outcomes.

A High Resolution Scale-of-four

DOE R&D Accomplishments Database

Fitch, V.

1949-08-25

A high resolution scale-of-four has been developed to be used in conjunction with the nuclear particle detection devices in applications where the counting rate is unusually high. Specifically, it is intended to precede the commercially available medium resolution scaling circuits and so decrease the resolving time of the counting system. The circuit will function reliably on continuously recurring pulses separated by less than 0.1 microseconds. It will resolve two pulses (occurring at a moderate repetition rate) which are spaced at 0.04 microseconds. A five-volt input signal is sufficient to actuate the device.

Integrating Eddy Covariance, Penman-Monteith and METRIC based Evapotranspiration estimates to generate high resolution space-time ET over the Brazos River Basin

NASA Astrophysics Data System (ADS)

Mbabazi, D.; Mohanty, B.; Gaur, N.

2017-12-01

Evapotranspiration (ET) is an important component of the water and energy balance and accounts for 60 -70% of precipitation losses. However, accurate estimates of ET are difficult to quantify at varying spatial and temporal scales. Eddy covariance methods estimate ET at high temporal resolutions but without capturing the spatial variation in ET within its footprint. On the other hand, remote sensing methods using Landsat imagery provide ET with high spatial resolution but low temporal resolution (16 days). In this study, we used both eddy covariance and remote sensing methods to generate high space-time resolution ET. Daily, monthly and seasonal ET estimates were obtained using the eddy covariance (EC) method, Penman-Monteith (PM) and Mapping Evapotranspiration with Internalized Calibration (METRIC) models to determine cotton and native prairie ET dynamics in the Brazos river basin characterized by varying hydro-climatic and geological gradients. Daily estimates of spatially distributed ET (30 m resolution) were generated using spatial autocorrelation and temporal interpolations between the EC flux variable footprints and METRIC ET for the 2016 and 2017 growing seasons. A comparison of the 2016 and 2017 preliminary daily ET estimates showed similar ET dynamics/trends among the EC, PM and METRIC methods, and 5-20% differences in seasonal ET estimates. This study will improve the spatial estimates of EC ET and temporal resolution of satellite derived ET thus providing better ET data for water use management.

Study of Saturn Electrostatic Discharges in a Wide Range of Timec SCALES

NASA Astrophysics Data System (ADS)

Mylostna, K.; Zakharenko, V.; Konovalenko, A.; Kolyadin, V.; Zarka, P.; Griemeier, J.-M.; Litvinenko, G.; Sidorchuk, M.; Rucker, H.; Fischer, G.; Cecconi, B.; Coffre, A.; Denis, L.; Nikolaenko, V.; Shevchenko, V.

Saturn Electrostatic discharges (SED) are sporadic broadband impulsive radio bursts associated with lightning in Saturnian atmosphere. After 25 years of space investigations in 2006 the first successful observations of SED on the UTR-2 radio telescope were carried out [1]. Since 2007 a long-term program of ED search and study in the Solar system has started. As a part of this program the unique observations with high time resolution were taken in 2010. New possibilities of UTR-2 radio telescope allowed to provide a long-period observations and study with high temporal resolution. This article presents the results of SED study in a wide range of time scales: from seconds to microseconds. For the first time there were obtained a low frequency spectrum of SED. We calculated flux densities of individual bursts at the maximum achievable time resolution. Flux densities of most intensive bursts reach 4200 Jy.

Static Time-of-Flight Secondary Ion Mass Spectrometry (SIMS) | Materials

Science.gov Websites

-Flight Secondary Ion Mass Spectrometry (SIMS) Image of high mass resolution and mass accuracy provided by TOF SIMS We used the high mass resolution and mass accuracy of TOF SIMS to study surface cleanliness acidic wash resulted in contamination by Fe and other metals. Without high mass accuracy, the CaO signal

A Subsystem Test Bed for Chinese Spectral Radioheliograph

NASA Astrophysics Data System (ADS)

Zhao, An; Yan, Yihua; Wang, Wei

2014-11-01

The Chinese Spectral Radioheliograph is a solar dedicated radio interferometric array that will produce high spatial resolution, high temporal resolution, and high spectral resolution images of the Sun simultaneously in decimetre and centimetre wave range. Digital processing of intermediate frequency signal is an important part in a radio telescope. This paper describes a flexible and high-speed digital down conversion system for the CSRH by applying complex mixing, parallel filtering, and extracting algorithms to process IF signal at the time of being designed and incorporates canonic-signed digit coding and bit-plane method to improve program efficiency. The DDC system is intended to be a subsystem test bed for simulation and testing for CSRH. Software algorithms for simulation and hardware language algorithms based on FPGA are written which use less hardware resources and at the same time achieve high performances such as processing high-speed data flow (1 GHz) with 10 MHz spectral resolution. An experiment with the test bed is illustrated by using geostationary satellite data observed on March 20, 2014. Due to the easy alterability of the algorithms on FPGA, the data can be recomputed with different digital signal processing algorithms for selecting optimum algorithm.

High-spatial-resolution nanoparticle x-ray fluorescence tomography

NASA Astrophysics Data System (ADS)

Larsson, Jakob C.; Vâgberg, William; Vogt, Carmen; Lundström, Ulf; Larsson, Daniel H.; Hertz, Hans M.

2016-03-01

X-ray fluorescence tomography (XFCT) has potential for high-resolution 3D molecular x-ray bio-imaging. In this technique the fluorescence signal from targeted nanoparticles (NPs) is measured, providing information about the spatial distribution and concentration of the NPs inside the object. However, present laboratory XFCT systems typically have limited spatial resolution (>1 mm) and suffer from long scan times and high radiation dose even at high NP concentrations, mainly due to low efficiency and poor signal-to-noise ratio. We have developed a laboratory XFCT system with high spatial resolution (sub-100 μm), low NP concentration and vastly decreased scan times and dose, opening up the possibilities for in-vivo small-animal imaging research. The system consists of a high-brightness liquid-metal-jet microfocus x-ray source, x-ray focusing optics and an energy-resolving photon-counting detector. By using the source's characteristic 24 keV line-emission together with carefully matched molybdenum nanoparticles the Compton background is greatly reduced, increasing the SNR. Each measurement provides information about the spatial distribution and concentration of the Mo nanoparticles. A filtered back-projection method is used to produce the final XFCT image.

Study of high resolution x-ray spectrometer concepts for NIF experiments

NASA Astrophysics Data System (ADS)

Hill, K. W.; Bitter, M.; Delgado-Aparicio, L.; Efthimion, P.; Gao, L.; Maddox, J.; Pablant, N. A.; Beiersdorfer, P.; Chen, H.; Coppari, F.; Ma, T.; Nora, R.; Scott, H.; Schneider, M.; Mancini, R.

2015-11-01

Options have been investigated for DIM-insertable (Diagnostic Instrument Manipulator) high resolution (E/ ΔE ~ 3000 - 5000) Bragg crystal x-ray spectrometers for experiments on the NIF. Of interest are time integrated Cu K- and Ta L-edge absorption spectra and time resolved Kr He- β emission from compressed symcaps for inference of electron temperature from dielectronic satellites and electron density from Stark broadening. Cylindrical and conical von Hamos, Johann, and advanced high throughput designs have been studied. Predicted x-ray intensities, spectrometer throughputs, spectral resolution, and spatial focusing properties, as well as lab evaluations of some spectrometer candidates will be presented. Performed under the auspices of the US DOE by PPPL under contract DE-AC02-09CH11466 and by LLNL under contract DE-AC52-07NA27344.

Recent applications of gas chromatography with high-resolution mass spectrometry.

PubMed

Špánik, Ivan; Machyňáková, Andrea

2018-01-01

Gas chromatography coupled to high-resolution mass spectrometry is a powerful analytical method that combines excellent separation power of gas chromatography with improved identification based on an accurate mass measurement. These features designate gas chromatography with high-resolution mass spectrometry as the first choice for identification and structure elucidation of unknown volatile and semi-volatile organic compounds. Gas chromatography with high-resolution mass spectrometry quantitative analyses was previously focused on the determination of dioxins and related compounds using magnetic sector type analyzers, a standing requirement of many international standards. The introduction of a quadrupole high-resolution time-of-flight mass analyzer broadened interest in this method and novel applications were developed, especially for multi-target screening purposes. This review is focused on the development and the most interesting applications of gas chromatography coupled to high-resolution mass spectrometry towards analysis of environmental matrices, biological fluids, and food safety since 2010. The main attention is paid to various approaches and applications of gas chromatography coupled to high-resolution mass spectrometry for non-target screening to identify contaminants and to characterize the chemical composition of environmental, food, and biological samples. The most interesting quantitative applications, where a significant contribution of gas chromatography with high-resolution mass spectrometry over the currently used methods is expected, will be discussed as well. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Tablet disintegration studied by high-resolution real-time magnetic resonance imaging.

PubMed

Quodbach, Julian; Moussavi, Amir; Tammer, Roland; Frahm, Jens; Kleinebudde, Peter

2014-01-01

The present work employs recent advances in high-resolution real-time magnetic resonance imaging (MRI) to investigate the disintegration process of tablets containing disintegrants. A temporal resolution of 75 ms and a spatial resolution of 80 × 80 µm with a section thickness of only 600 µm were achieved. The histograms of MRI videos were quantitatively analyzed with MATLAB. The mechanisms of action of six commercially available disintegrants, the influence of relative tablet density, and the impact of disintegrant concentration were examined. Crospovidone seems to be the only disintegrant acting by a shape memory effect, whereas the others mainly swell. A higher relative density of tablets containing croscarmellose sodium leads to a more even distribution of water within the tablet matrix but hardly impacts the disintegration kinetics. Increasing the polacrilin potassium disintegrant concentration leads to a quicker and more thorough disintegration process. Real-time MRI emerges as valuable tool to visualize and investigate the process of tablet disintegration.

High spatial resolution distributed fiber system for multi-parameter sensing based on modulated pulses.

PubMed

Zhang, Jingdong; Zhu, Tao; Zhou, Huan; Huang, Shihong; Liu, Min; Huang, Wei

2016-11-28

We demonstrate a cost-effective distributed fiber sensing system for the multi-parameter detection of the vibration, the temperature, and the strain by integrating phase-sensitive optical time domain reflectometry (φ-OTDR) and Brillouin optical time domain reflectometry (B-OTDR). Taking advantage of the fast changing property of the vibration and the static properties of the temperature and the strain, both the width and intensity of the laser pulses are modulated and injected into the single-mode sensing fiber proportionally, so that three concerned parameters can be extracted simultaneously by only one photo-detector and one data acquisition channel. A data processing method based on Gaussian window short time Fourier transform (G-STFT) is capable of achieving high spatial resolution in B-OTDR. The experimental results show that up to 4.8kHz vibration sensing with 3m spatial resolution at 10km standard single-mode fiber can be realized, as well as the distributed temperature and stress profiles along the same fiber with 80cm spatial resolution.

Three-dimensional laser microvision.

PubMed

Shimotahira, H; Iizuka, K; Chu, S C; Wah, C; Costen, F; Yoshikuni, Y

2001-04-10

A three-dimensional (3-D) optical imaging system offering high resolution in all three dimensions, requiring minimum manipulation and capable of real-time operation, is presented. The system derives its capabilities from use of the superstructure grating laser source in the implementation of a laser step frequency radar for depth information acquisition. A synthetic aperture radar technique was also used to further enhance its lateral resolution as well as extend the depth of focus. High-speed operation was made possible by a dual computer system consisting of a host and a remote microcomputer supported by a dual-channel Small Computer System Interface parallel data transfer system. The system is capable of operating near real time. The 3-D display of a tunneling diode, a microwave integrated circuit, and a see-through image taken by the system operating near real time are included. The depth resolution is 40 mum; lateral resolution with a synthetic aperture approach is a fraction of a micrometer and that without it is approximately 10 mum.

High resolution physical mapping of single gene fragments on pachytene chromosome 4 and 7 of Rosa.

PubMed

Kirov, Ilya V; Van Laere, Katrijn; Khrustaleva, Ludmila I

2015-07-02

Rosaceae is a family containing many economically important fruit and ornamental species. Although fluorescence in situ hybridization (FISH)-based physical mapping of plant genomes is a valuable tool for map-based cloning, comparative genomics and evolutionary studies, no studies using high resolution physical mapping have been performed in this family. Previously we proved that physical mapping of single-copy genes as small as 1.1 kb is possible on mitotic metaphase chromosomes of Rosa wichurana using Tyramide-FISH. In this study we aimed to further improve the physical map of Rosa wichurana by applying high resolution FISH to pachytene chromosomes. Using high resolution Tyramide-FISH and multicolor Tyramide-FISH, 7 genes (1.7-3 kb) were successfully mapped on pachytene chromosomes 4 and 7 of Rosa wichurana. Additionally, by using multicolor Tyramide-FISH three closely located genes were simultaneously visualized on chromosome 7. A detailed map of heterochromatine/euchromatine patterns of chromosome 4 and 7 was developed with indication of the physical position of these 7 genes. Comparison of the gene order between Rosa wichurana and Fragaria vesca revealed a poor collinearity for chromosome 7, but a perfect collinearity for chromosome 4. High resolution physical mapping of short probes on pachytene chromosomes of Rosa wichurana was successfully performed for the first time. Application of Tyramide-FISH on pachytene chromosomes allowed the mapping resolution to be increased up to 20 times compared to mitotic metaphase chromosomes. High resolution Tyramide-FISH and multicolor Tyramide-FISH might become useful tools for further physical mapping of single-copy genes and for the integration of physical and genetic maps of Rosa wichurana and other members of the Rosaceae.

Detection of high energy muons with sub-20 ps timing resolution using L(Y)SO crystals and SiPM readout

NASA Astrophysics Data System (ADS)

Benaglia, A.; Gundacker, S.; Lecoq, P.; Lucchini, M. T.; Para, A.; Pauwels, K.; Auffray, E.

2016-09-01

Precise timing capability will be a key aspect of particle detectors at future high energy colliders, as the time information can help in the reconstruction of physics events at the high collision rate expected there. Other than being used in detectors for PET, fast scintillating crystals coupled to compact Silicon Photomultipliers (SiPMs) constitute a versatile system that can be exploited to realize an ad-hoc timing device to be hosted in a larger high energy physics detector. In this paper, we present the timing performance of LYSO:Ce and LSO:Ce codoped 0.4% Ca crystals coupled to SiPMs, as measured with 150 GeV muons at the CERN SPS H2 extraction line. Small crystals, with lengths ranging from 5 mm up to 30 mm and transverse size of 2 × 2mm2 or 3 × 3mm2 , were exposed to a 150 GeV muon beam. SiPMs from two different companies (Hamamatsu and FBK) were used to detect the light produced in the crystals. The best coincidence time resolution value of (14.5 ± 0.5) ps , corresponding to a single-detector time resolution of about 10 ps, is demonstrated for 5 mm long LSO:Ce,Ca crystals coupled to FBK SiPMs, when time walk corrections are applied.

Determination of atomic positions from time resolved high resolution transmission electron microscopy images.

PubMed

Hussaini, Zahra; Lin, Pin Ann; Natarajan, Bharath; Zhu, Wenhui; Sharma, Renu

2018-03-01

For many reaction processes, such as catalysis, phase transformations, nanomaterial synthesis etc., nanoscale observations at high spatial (sub-nanometer) and temporal (millisecond) resolution are required to characterize and comprehend the underlying factors that favor one reaction over another. The combination of such spatial and temporal resolution (up to 600 µs), while rich in information, produces a large number of snapshots, each of which must be analyzed to obtain the structural (and thereby chemical) information. Here we present a methodology for automated quantitative measurement of real-time atomic position fluctuations in a nanoparticle. We leverage a combination of several image processing algorithms to precisely identify the positions of the atomic columns in each image. A geometric model is then used to measure the time-evolution of distances and angles between neighboring atomic columns to identify different phases and quantify local structural fluctuations. We apply this technique to determine the atomic-level fluctuations in the relative fractions of metal and metal-carbide phases in a cobalt catalyst nanoparticle during single-walled carbon nanotube (SWCNT) growth. These measurements provided a means to obtain the number of carbon atoms incorporated into and released from the catalyst particle, thereby helping resolve carbon reaction pathways during SWCNT growth. Further we demonstrate the use of this technique to measure the reaction kinetics of iron oxide reduction. Apart from reducing the data analysis time, the statistical approach allows us to measure atomic distances with sub-pixel resolution. We show that this method can be applied universally to measure atomic positions with a precision of 0.01 nm from any set of atomic-resolution video images. With the advent of high time-resolution direct detection cameras, we anticipate such methods will be essential in addressing the metrology problem of quantifying large datasets of time-resolved images in future. Published by Elsevier B.V.

Design of a high speed, high resolution thermometry system for 1.5 GHz superconducting radio frequency cavities

NASA Astrophysics Data System (ADS)

Knobloch, Jens; Muller, Henry; Padamsee, Hasan

1994-11-01

Presented in this paper are the description and the test results of a new stationary thermometry system used to map the temperature of the outer surface of 1.5 GHz superconducting single-cell cavities during operation at 1.6 K. The system comprises 764 removable carbon thermometers whose signals are multiplexed and scanned by a Macintosh computer. A complete temperature map can be obtained in as little as 0.1 s at a temperature resolution of about 0.2 mK. Alternatively, it has been demonstrated that if the acquisition time is increased to several seconds, then a temperature resolution on the order of 30 μK is possible. To our knowledge, these are the fastest acquisition times so far achieved with L-band cavities at these resolutions.

High resolution time interval counter

DOEpatents

Condreva, Kenneth J.

1994-01-01

A high resolution counter circuit measures the time interval between the occurrence of an initial and a subsequent electrical pulse to two nanoseconds resolution using an eight megahertz clock. The circuit includes a main counter for receiving electrical pulses and generating a binary word--a measure of the number of eight megahertz clock pulses occurring between the signals. A pair of first and second pulse stretchers receive the signal and generate a pair of output signals whose widths are approximately sixty-four times the time between the receipt of the signals by the respective pulse stretchers and the receipt by the respective pulse stretchers of a second subsequent clock pulse. Output signals are thereafter supplied to a pair of start and stop counters operable to generate a pair of binary output words representative of the measure of the width of the pulses to a resolution of two nanoseconds. Errors associated with the pulse stretchers are corrected by providing calibration data to both stretcher circuits, and recording start and stop counter values. Stretched initial and subsequent signals are combined with autocalibration data and supplied to an arithmetic logic unit to determine the time interval in nanoseconds between the pair of electrical pulses being measured.

High resolution time interval counter

DOEpatents

Condreva, K.J.

1994-07-26

A high resolution counter circuit measures the time interval between the occurrence of an initial and a subsequent electrical pulse to two nanoseconds resolution using an eight megahertz clock. The circuit includes a main counter for receiving electrical pulses and generating a binary word--a measure of the number of eight megahertz clock pulses occurring between the signals. A pair of first and second pulse stretchers receive the signal and generate a pair of output signals whose widths are approximately sixty-four times the time between the receipt of the signals by the respective pulse stretchers and the receipt by the respective pulse stretchers of a second subsequent clock pulse. Output signals are thereafter supplied to a pair of start and stop counters operable to generate a pair of binary output words representative of the measure of the width of the pulses to a resolution of two nanoseconds. Errors associated with the pulse stretchers are corrected by providing calibration data to both stretcher circuits, and recording start and stop counter values. Stretched initial and subsequent signals are combined with autocalibration data and supplied to an arithmetic logic unit to determine the time interval in nanoseconds between the pair of electrical pulses being measured. 3 figs.

A near-infrared SETI experiment: A multi-time resolution data analysis

NASA Astrophysics Data System (ADS)

Tallis, Melisa; Maire, Jerome; Wright, Shelley; Drake, Frank D.; Duenas, Andres; Marcy, Geoffrey W.; Stone, Remington P. S.; Treffers, Richard R.; Werthimer, Dan; NIROSETI

2016-06-01

We present new post-processing routines which are used to detect very fast optical and near-infrared pulsed signals using the latest NIROSETI (Near-Infrared Optical Search for Extraterrestrial Intelligence) instrument. NIROSETI was commissioned in 2015 at Lick Observatory and searches for near-infrared (0.95 to 1.65μ) nanosecond pulsed laser signals transmitted by distant civilizations. Traditional optical SETI searches rely on analysis of coincidences that occur between multiple detectors at a fixed time resolution. We present a multi-time resolution data analysis that extends our search from the 1ns to 1ms range. This new feature greatly improves the versatility of the instrument and its search parameters for near-infrared SETI. We aim to use these algorithms to assist us in our search for signals that have varying duty cycles and pulse widths. We tested the fidelity and robustness of our algorithms using both synthetic embedded pulsed signals, as well as data from a near-infrared pulsed laser installed on the instrument. Applications of NIROSETI are widespread in time domain astrophysics, especially for high time resolution transients, and astronomical objects that emit short-duration high-energy pulses such as pulsars.

Development of depth encoding small animal PET detectors using dual-ended readout of pixelated scintillator arrays with SiPMs.

PubMed

Kuang, Zhonghua; Sang, Ziru; Wang, Xiaohui; Fu, Xin; Ren, Ning; Zhang, Xianming; Zheng, Yunfei; Yang, Qian; Hu, Zhanli; Du, Junwei; Liang, Dong; Liu, Xin; Zheng, Hairong; Yang, Yongfeng

2018-02-01

The performance of current small animal PET scanners is mainly limited by the detector performance and depth encoding detectors are required to develop PET scanner to simultaneously achieve high spatial resolution and high sensitivity. Among all depth encoding PET detector approaches, dual-ended readout detector has the advantage to achieve the highest depth of interaction (DOI) resolution and spatial resolution. Silicon photomultiplier (SiPM) is believed to be the photodetector of the future for PET detector due to its excellent properties as compared to the traditional photodetectors such as photomultiplier tube (PMT) and avalanche photodiode (APD). The purpose of this work is to develop high resolution depth encoding small animal PET detector using dual-ended readout of finely pixelated scintillator arrays with SiPMs. Four lutetium-yttrium oxyorthosilicate (LYSO) arrays with 11 × 11 crystals and 11.6 × 11.6 × 20 mm 3 outside dimension were made using ESR, Toray and BaSO 4 reflectors. The LYSO arrays were read out with Hamamatsu 4 × 4 SiPM arrays from both ends. The SiPM array has a pixel size of 3 × 3 mm 2 , 0.2 mm gap in between the pixels and a total active area of 12.6 × 12.6 mm 2 . The flood histograms, DOI resolution, energy resolution and timing resolution of the four detector modules were measured and compared. All crystals can be clearly resolved from the measured flood histograms of all four arrays. The BaSO 4 arrays provide the best and the ESR array provides the worst flood histograms. The DOI resolution obtained from the DOI profiles of the individual crystals of the four array is from 2.1 to 2.35 mm for events with E > 350 keV. The DOI ratio variation among crystals is bigger for the BaSO 4 arrays as compared to both the ESR and Toray arrays. The BaSO 4 arrays provide worse detector based DOI resolution. The photopeak amplitude of the Toray array had the maximum change with depth, it provides the worst energy resolution of 21.3%. The photopeak amplitude of the BaSO 4 array with 80 μm reflector almost doesn't change with depth, it provides the best energy resolution of 12.9%. A maximum timing shift of 1.37 ns to 1.61 ns among the corner and the center crystals in the four arrays was obtained due to the use of resistor network readout. A crystal based timing resolution of 0.68 ns to 0.83 ns and a detector based timing resolution of 1.26 ns to 1.45 ns were obtained for the four detector modules. Four high resolution depth encoding small animal PET detectors were developed using dual-ended readout of pixelated scintillator arrays with SiPMs. The performance results show that those detectors can be used to build a small animal PET scanner to simultaneously achieve uniform high spatial resolution and high sensitivity. © 2017 American Association of Physicists in Medicine.

Assessment and Prediction of Natural Hazards from Satellite Imagery

PubMed Central

Gillespie, Thomas W.; Chu, Jasmine; Frankenberg, Elizabeth; Thomas, Duncan

2013-01-01

Since 2000, there have been a number of spaceborne satellites that have changed the way we assess and predict natural hazards. These satellites are able to quantify physical geographic phenomena associated with the movements of the earth’s surface (earthquakes, mass movements), water (floods, tsunamis, storms), and fire (wildfires). Most of these satellites contain active or passive sensors that can be utilized by the scientific community for the remote sensing of natural hazards over a number of spatial and temporal scales. The most useful satellite imagery for the assessment of earthquake damage comes from high-resolution (0.6 m to 1 m pixel size) passive sensors and moderate resolution active sensors that can quantify the vertical and horizontal movement of the earth’s surface. High-resolution passive sensors have been used to successfully assess flood damage while predictive maps of flood vulnerability areas are possible based on physical variables collected from passive and active sensors. Recent moderate resolution sensors are able to provide near real time data on fires and provide quantitative data used in fire behavior models. Limitations currently exist due to atmospheric interference, pixel resolution, and revisit times. However, a number of new microsatellites and constellations of satellites will be launched in the next five years that contain increased resolution (0.5 m to 1 m pixel resolution for active sensors) and revisit times (daily ≤ 2.5 m resolution images from passive sensors) that will significantly improve our ability to assess and predict natural hazards from space. PMID:25170186

Studies on fast triggering and high precision tracking with Resistive Plate Chambers

NASA Astrophysics Data System (ADS)

Aielli, G.; Ball, R.; Bilki, B.; Chapman, J. W.; Cardarelli, R.; Dai, T.; Diehl, E.; Dubbert, J.; Ferretti, C.; Feng, H.; Francis, K.; Guan, L.; Han, L.; Hou, S.; Levin, D.; Li, B.; Liu, L.; Paolozzi, L.; Repond, J.; Roloff, J.; Santonico, R.; Song, H. Y.; Wang, X. L.; Wu, Y.; Xia, L.; Xu, L.; Zhao, T.; Zhao, Z.; Zhou, B.; Zhu, J.

2013-06-01

We report on studies of fast triggering and high precision tracking using Resistive Plate Chambers (RPCs). Two beam tests were carried out with the 180 GeV/c muon beam at CERN using glass RPCs with gas gaps of 1.15 mm and equipped with readout strips with 1.27 mm pitch. This is the first beam test of RPCs with fine-pitch readout strips that explores precision tracking and triggering capabilities. RPC signals were acquired with precision timing and charge integrating readout electronics at both ends of the strips. The time resolution was measured to be better than 600 ps and the average spatial resolution was found to be 220 μm using charge information and 287 μm only using signal arrival time information. The dual-ended readout allows the determination of the average and the difference of the signal arrival times. The average time was found to be independent of the incident particle position along the strip and is useful for triggering purposes. The time difference yielded a determination of the hit position with a precision of 7.5 mm along the strip. These results demonstrate the feasibility using RPCs for fast and high-resolution triggering and tracking.

The robustness of T2 value as a trabecular structural index at multiple spatial resolutions of 7 Tesla MRI.

PubMed

Lee, D K; Song, Y K; Park, B W; Cho, H P; Yeom, J S; Cho, G; Cho, H

2018-04-15

To evaluate the robustness of MR transverse relaxation times of trabecular bone from spin-echo and gradient-echo acquisitions at multiple spatial resolutions of 7 T. The effects of MRI resolutions to T 2 and T2* of trabecular bone were numerically evaluated by Monte Carlo simulations. T 2 , T2*, and trabecular structural indices from multislice multi-echo and UTE acquisitions were measured in defatted human distal femoral condyles on a 7 T scanner. Reference structural indices were extracted from high-resolution microcomputed tomography images. For bovine knee trabecular samples with intact bone marrow, T 2 and T2* were measured by degrading spatial resolutions on a 7 T system. In the defatted trabecular experiment, both T 2 and T2* values showed strong ( |r| > 0.80) correlations with trabecular spacing and number, at a high spatial resolution of 125 µm 3 . The correlations for MR image-segmentation-derived structural indices were significantly degraded ( |r| < 0.50) at spatial resolutions of 250 and 500 µm 3 . The correlations for T2* rapidly dropped ( |r| < 0.50) at a spatial resolution of 500 µm 3 , whereas those for T 2 remained consistently high ( |r| > 0.85). In the bovine trabecular experiments with intact marrow, low-resolution (approximately 1 mm 3 , 2 minutes) T 2 values did not shorten ( |r| > 0.95 with respect to approximately 0.4 mm 3 , 11 minutes) and maintained consistent correlations ( |r| > 0.70) with respect to trabecular spacing (turbo spin echo, 22.5 minutes). T 2 measurements of trabeculae at 7 T are robust with degrading spatial resolution and may be preferable in assessing trabecular spacing index with reduced scan time, when high-resolution 3D micro-MRI is difficult to obtain. © 2018 International Society for Magnetic Resonance in Medicine.

Triple Quadrupole Versus High Resolution Quadrupole-Time-of-Flight Mass Spectrometry for Quantitative LC-MS/MS Analysis of 25-Hydroxyvitamin D in Human Serum

NASA Astrophysics Data System (ADS)

Geib, Timon; Sleno, Lekha; Hall, Rabea A.; Stokes, Caroline S.; Volmer, Dietrich A.

2016-08-01

We describe a systematic comparison of high and low resolution LC-MS/MS assays for quantification of 25-hydroxyvitamin D3 in human serum. Identical sample preparation, chromatography separations, electrospray ionization sources, precursor ion selection, and ion activation were used; the two assays differed only in the implemented final mass analyzer stage; viz. high resolution quadrupole-quadrupole-time-of-flight (QqTOF) versus low resolution triple quadrupole instruments. The results were assessed against measured concentration levels from a routine clinical chemiluminescence immunoassay. Isobaric interferences prevented the simple use of TOF-MS spectra for extraction of accurate masses and necessitated the application of collision-induced dissociation on the QqTOF platform. The two mass spectrometry assays provided very similar analytical figures of merit, reflecting the lack of relevant isobaric interferences in the MS/MS domain, and were successfully applied to determine the levels of 25-hydroxyvitamin D for patients with chronic liver disease.

Analysis of the precipitation and streamflow extremes in Northern Italy using high resolution reanalysis dataset Express-Hydro

NASA Astrophysics Data System (ADS)

Silvestro, Francesco; Parodi, Antonio; Campo, Lorenzo

2017-04-01

The characterization of the hydrometeorological extremes, both in terms of rainfall and streamflow, in a given region plays a key role in the environmental monitoring provided by the flood alert services. In last years meteorological simulations (both near real-time and historical reanalysis) were available at increasing spatial and temporal resolutions, making possible long-period hydrological reanalysis in which the meteo dataset is used as input in distributed hydrological models. In this work, a very high resolution meteorological reanalysis dataset, namely Express-Hydro (CIMA, ISAC-CNR, GAUSS Special Project PR45DE), was employed as input in the hydrological model Continuum in order to produce long time series of streamflows in the Liguria territory, located in the Northern part of Italy. The original dataset covers the whole Europe territory in the 1979-2008 period, at 4 km of spatial resolution and 3 hours of time resolution. Analyses in terms of comparison between the rainfall estimated by the dataset and the observations (available from the local raingauges network) were carried out, and a bias correction was also performed in order to better match the observed climatology. An extreme analysis was eventually carried on the streamflows time series obtained by the simulations, by comparing them with the results of the same hydrological model fed with the observed time series of rainfall. The results of the analysis are shown and discussed.

Assimilation of SMOS (and SMAP) Retrieved Soil Moisture into the Land Information System

NASA Technical Reports Server (NTRS)

Blankenship, Clay; Zavodsky, Bradley; Case, Jonathan; Stano, Geoffrey

2016-01-01

Goal: Accurate, high-resolution (approx.3 km) soil moisture in near-real time. Situational awareness (drought assessment, flood and fire threat). Local modeling applications (to improve sfc-PBL exchanges) Method: Assimilate satellite soil moisture retrievals into a land surface model. Combines high-resolution geophysical model data with latest satellite observations.

Method to determine thermal profiles of nanoscale circuitry

DOEpatents

Zettl, Alexander K; Begtrup, Gavi E

2013-04-30

A platform that can measure the thermal profiles of devices with nanoscale resolution has been developed. The system measures the local temperature by using an array of nanoscale thermometers. This process can be observed in real time using a high resolution imagining technique such as electron microscopy. The platform can operate at extremely high temperatures.

LYSO based precision timing calorimeters

DOE PAGES

Bornheim, A.; Apresyan, A.; Ronzhin, A.; ...

2017-11-01

In this report we outline the study of the development of calorimeter detectors using bright scintillating crystals. We discuss how timing information with a precision of a few tens of pico seconds and below can significantly improve the reconstruction of the physics events under challenging high pileup conditions to be faced at the High-Luminosity LHC or a future hadron collider. The particular challenge in measuring the time of arrival of a high energy photon lies in the stochastic component of the distance of initial conversion and the size of the electromagnetic shower. We present studies and measurements from test beamsmore » for calorimeter based timing measurements to explore the ultimate timing precision achievable for high energy photons of 10 GeV and above. We focus on techniques to measure the timing with a high precision in association with the energy of the photon. We present test-beam studies and results on the timing performance and characterization of the time resolution of LYSO-based calorimeters. We demonstrate time resolution of 30 ps is achievable for a particular design.« less

Quantification of polychlorinated dibenzo-p-dioxins and dibenzofurans by direct injection of sample extract into the comprehensive multidimensional gas chromatograph/high-resolution time-of-flight mass spectrometer.

PubMed

Shunji, Hashimoto; Yoshikatsu, Takazawa; Akihiro, Fushimi; Hiroyasu, Ito; Kiyoshi, Tanabe; Yasuyuki, Shibata; Masa-aki, Ubukata; Akihiko, Kusai; Kazuo, Tanaka; Hideyuki, Otsuka; Katsunori, Anezaki

2008-01-18

Polychlorinated dibenzo-p-dioxins and dibenzofurans in crude extracts of fly ash and flue gas from municipal waste incinerators were quantified using a comprehensive multidimensional gas chromatograph (GC x GC) coupled to a high-resolution time-of-flight mass spectrometer (HR-TOFMS). For identification and quantification, we developed our own program to prepare 3D chromatograms of selected mass numbers from the data of the GC x GC/HR-TOFMS. Isolation of all congeners with a TCDD toxic equivalency factor from the other isomers by only one injection was confirmed. The instrumental detection limit of TCDD on the GC x GC/HR-TOFMS was 0.9 pg by the relative calibration method. Quantification of these substances in the crude extracts was achieved by direct injection to the GC x GC/HR-TOFMS. The results agree with the values obtained using a generic gas chromatography/high-resolution mass spectrometry (GC/HRMS) system. It was confirmed that measurement by high-resolution TOFMS and GC x GC effectively reduces interference from other chemicals.

Compressed Sensing for Resolution Enhancement of Hyperpolarized 13C Flyback 3D-MRSI

PubMed Central

Hu, Simon; Lustig, Michael; Chen, Albert P.; Crane, Jason; Kerr, Adam; Kelley, Douglas A.C.; Hurd, Ralph; Kurhanewicz, John; Nelson, Sarah J.; Pauly, John M.; Vigneron, Daniel B.

2008-01-01

High polarization of nuclear spins in liquid state through dynamic nuclear polarization has enabled the direct monitoring of 13C metabolites in vivo at very high signal to noise, allowing for rapid assessment of tissue metabolism. The abundant SNR afforded by this hyperpolarization technique makes high resolution 13C 3D-MRSI feasible. However, the number of phase encodes that can be fit into the short acquisition time for hyperpolarized imaging limits spatial coverage and resolution. To take advantage of the high SNR available from hyperpolarization, we have applied compressed sensing to achieve a factor of 2 enhancement in spatial resolution without increasing acquisition time or decreasing coverage. In this paper, the design and testing of compressed sensing suited for a flyback 13C 3D-MRSI sequence are presented. The key to this design was the undersampling of spectral k-space using a novel blipped scheme, thus taking advantage of the considerable sparsity in typical hyperpolarized 13C spectra. Phantom tests validated the accuracy of the compressed sensing approach and initial mouse experiments demonstrated in vivo feasibility. PMID:18367420

Evaluation of high resolution ultrasound as a tool for assessing the 3D volume of blood clots during in vitro thrombolysis.

PubMed

Auboire, Laurent; Escoffre, Jean-Michel; Fouan, Damien; Jacquet, Jean-René; Ossant, Frédéric; Grégoire, Jean-Marc; Bouakaz, Ayache

2017-07-24

Thrombosis is a major cause of several diseases, i.e. myocardial infarction, cerebral stroke and pulmonary embolism. Thrombolytic therapies are required to induce fast and efficient recanalization of occluded vessels. To evaluate the in vitro efficacy of these thrombolytic strategies, measuring clot dissolution is essential. This study aimed to evaluate and validate high resolution ultrasound as a tool to assess the exact volume of clots in 3D and in real time during in vitro thrombolytic drug testing. This new method was validated by measuring the effects of concentration range of recombinant tissue type plasminogen activator on a blood clot during complete occlusion or 70% stenosis of a vessel. This study shows that high resolution ultrasound imaging allows for a real-time assessment of the 3D volume of a blood clot with negligible inter- and intra-operator variabilities. The conclusions drawn from this study demonstrate the promising potential of high resolution ultrasound imaging for the in vitro assessment of new thrombolytic drugs.

An electron beam linear scanning mode for industrial limited-angle nano-computed tomography.

PubMed

Wang, Chengxiang; Zeng, Li; Yu, Wei; Zhang, Lingli; Guo, Yumeng; Gong, Changcheng

2018-01-01

Nano-computed tomography (nano-CT), which utilizes X-rays to research the inner structure of some small objects and has been widely utilized in biomedical research, electronic technology, geology, material sciences, etc., is a high spatial resolution and non-destructive research technique. A traditional nano-CT scanning model with a very high mechanical precision and stability of object manipulator, which is difficult to reach when the scanned object is continuously rotated, is required for high resolution imaging. To reduce the scanning time and attain a stable and high resolution imaging in industrial non-destructive testing, we study an electron beam linear scanning mode of nano-CT system that can avoid mechanical vibration and object movement caused by the continuously rotated object. Furthermore, to further save the scanning time and study how small the scanning range could be considered with acceptable spatial resolution, an alternating iterative algorithm based on ℓ 0 minimization is utilized to limited-angle nano-CT reconstruction problem with the electron beam linear scanning mode. The experimental results confirm the feasibility of the electron beam linear scanning mode of nano-CT system.

T85C polymorphisms of the dihydropyrimidine dehydrogenase gene detected in gastric cancer tissues by high-resolution melting curve analysis.

PubMed

Fang, Weijia; Xu, Nong; Jin, Dazhi; Chen, Yu; Chen, Xiaogang; Zheng, Yi; Shen, Hong; Yuan, Ying; Zheng, Shusen

2012-01-01

Dihydropyrimidine dehydrogenase is a key enzyme acting on the metabolic pathway of medications for gastric cancer. High-resolution melting curve technology, which was developed recently, can distinguish the wild-type dihydropyrimidine dehydrogenase gene from multiple polymorphisms by fluorescent quantitative polymerase chain reaction products in a direct and effective manner. T85C polymorphisms of dihydropyrimidine dehydrogenase in the peripheral blood of 112 Chinese gastric cancer patients were detected by real-time polymerase chain reaction combined with high-resolution melting curve technology. Primer design, along with the reaction system and conditions, was optimized based on the GenBank sequence. Seventy nine cases of wild-type (TT, [70.5%]), 29 cases of heterozygous (TC, [25.9%]), and 4 cases of homozygous mutant (CC, [3.6%]) were observed. The result was completely consistent with the results of the sequencing. Real-time polymerase chain reaction combined with high-resolution melting curve technology is a rapid, simple, reliable, direct-viewing, and convenient method for the detection and screening of polymorphisms.

An electron beam linear scanning mode for industrial limited-angle nano-computed tomography

NASA Astrophysics Data System (ADS)

Wang, Chengxiang; Zeng, Li; Yu, Wei; Zhang, Lingli; Guo, Yumeng; Gong, Changcheng

2018-01-01

Nano-computed tomography (nano-CT), which utilizes X-rays to research the inner structure of some small objects and has been widely utilized in biomedical research, electronic technology, geology, material sciences, etc., is a high spatial resolution and non-destructive research technique. A traditional nano-CT scanning model with a very high mechanical precision and stability of object manipulator, which is difficult to reach when the scanned object is continuously rotated, is required for high resolution imaging. To reduce the scanning time and attain a stable and high resolution imaging in industrial non-destructive testing, we study an electron beam linear scanning mode of nano-CT system that can avoid mechanical vibration and object movement caused by the continuously rotated object. Furthermore, to further save the scanning time and study how small the scanning range could be considered with acceptable spatial resolution, an alternating iterative algorithm based on ℓ0 minimization is utilized to limited-angle nano-CT reconstruction problem with the electron beam linear scanning mode. The experimental results confirm the feasibility of the electron beam linear scanning mode of nano-CT system.

Time-efficient high-resolution whole-brain three-dimensional macromolecular proton fraction mapping

PubMed Central

Yarnykh, Vasily L.

2015-01-01

Purpose Macromolecular proton fraction (MPF) mapping is a quantitative MRI method that reconstructs parametric maps of a relative amount of macromolecular protons causing the magnetization transfer (MT) effect and provides a biomarker of myelination in neural tissues. This study aimed to develop a high-resolution whole-brain MPF mapping technique utilizing a minimal possible number of source images for scan time reduction. Methods The described technique is based on replacement of an actually acquired reference image without MT saturation by a synthetic one reconstructed from R1 and proton density maps, thus requiring only three source images. This approach enabled whole-brain three-dimensional MPF mapping with isotropic 1.25×1.25×1.25 mm3 voxel size and scan time of 20 minutes. The synthetic reference method was validated against standard MPF mapping with acquired reference images based on data from 8 healthy subjects. Results Mean MPF values in segmented white and gray matter appeared in close agreement with no significant bias and small within-subject coefficients of variation (<2%). High-resolution MPF maps demonstrated sharp white-gray matter contrast and clear visualization of anatomical details including gray matter structures with high iron content. Conclusions Synthetic reference method improves resolution of MPF mapping and combines accurate MPF measurements with unique neuroanatomical contrast features. PMID:26102097

High temporal resolution aerosol retrieval using Geostationary Ocean Color Imager: application and initial validation

NASA Astrophysics Data System (ADS)

Zhang, Yuhuan; Li, Zhengqiang; Zhang, Ying; Hou, Weizhen; Xu, Hua; Chen, Cheng; Ma, Yan

2014-01-01

The Geostationary Ocean Color Imager (GOCI) provides multispectral imagery of the East Asia region hourly from 9:00 to 16:00 local time (GMT+9) and collects multispectral imagery at eight spectral channels (412, 443, 490, 555, 660, 680, 745, and 865 nm) with a spatial resolution of 500 m. Thus, this technology brings significant advantages to high temporal resolution environmental monitoring. We present the retrieval of aerosol optical depth (AOD) in northern China based on GOCI data. Cross-calibration was performed against Moderate Resolution Imaging Spectrometer (MODIS) data in order to correct the land calibration bias of the GOCI sensor. AOD retrievals were then accomplished using a look-up table (LUT) strategy with assumptions of a quickly varying aerosol and a slowly varying surface with time. The AOD retrieval algorithm calculates AOD by minimizing the surface reflectance variations of a series of observations in a short period of time, such as several days. The monitoring of hourly AOD variations was implemented, and the retrieved AOD agreed well with AErosol RObotic NETwork (AERONET) ground-based measurements with a good R2 of approximately 0.74 at validation sites at the cities of Beijing and Xianghe, although intercept bias may be high in specific cases. The comparisons with MODIS products also show a good agreement in AOD spatial distribution. This work suggests that GOCI imagery can provide high temporal resolution monitoring of atmospheric aerosols over land, which is of great interest in climate change studies and environmental monitoring.

Two-photon imaging of spatially extended neuronal network dynamics with high temporal resolution.

PubMed

Lillis, Kyle P; Eng, Alfred; White, John A; Mertz, Jerome

2008-07-30

We describe a simple two-photon fluorescence imaging strategy, called targeted path scanning (TPS), to monitor the dynamics of spatially extended neuronal networks with high spatiotemporal resolution. Our strategy combines the advantages of mirror-based scanning, minimized dead time, ease of implementation, and compatibility with high-resolution low-magnification objectives. To demonstrate the performance of TPS, we monitor the calcium dynamics distributed across an entire juvenile rat hippocampus (>1.5mm), at scan rates of 100 Hz, with single cell resolution and single action potential sensitivity. Our strategy for fast, efficient two-photon microscopy over spatially extended regions provides a particularly attractive solution for monitoring neuronal population activity in thick tissue, without sacrificing the signal-to-noise ratio or high spatial resolution associated with standard two-photon microscopy. Finally, we provide the code to make our technique generally available.

Spread-Spectrum Beamforming and Clutter Filtering for Plane-Wave Color Doppler Imaging.

PubMed

Mansour, Omar; Poepping, Tamie L; Lacefield, James C

2016-07-21

Plane-wave imaging is desirable for its ability to achieve high frame rates, allowing the capture of fast dynamic events and continuous Doppler data. In most implementations of plane-wave imaging, multiple low-resolution images from different plane wave tilt angles are compounded to form a single high-resolution image, thereby reducing the frame rate. Compounding improves the lateral beam profile in the high-resolution image, but it also acts as a low-pass filter in slow time that causes attenuation and aliasing of signals with high Doppler shifts. This paper introduces a spread-spectrum color Doppler imaging method that produces high-resolution images without the use of compounding, thereby eliminating the tradeoff between beam quality, maximum unaliased Doppler frequency, and frame rate. The method uses a long, random sequence of transmit angles rather than a linear sweep of plane wave directions. The random angle sequence randomizes the phase of off-focus (clutter) signals, thereby spreading the clutter power in the Doppler spectrum, while keeping the spectrum of the in-focus signal intact. The ensemble of randomly tilted low-resolution frames also acts as the Doppler ensemble, so it can be much longer than a conventional linear sweep, thereby improving beam formation while also making the slow-time Doppler sampling frequency equal to the pulse repetition frequency. Experiments performed using a carotid artery phantom with constant flow demonstrate that the spread-spectrum method more accurately measures the parabolic flow profile of the vessel and outperforms conventional plane-wave Doppler in both contrast resolution and estimation of high flow velocities. The spread-spectrum method is expected to be valuable for Doppler applications that require measurement of high velocities at high frame rates.

An 18-ps TDC using timing adjustment and bin realignment methods in a Cyclone-IV FPGA

NASA Astrophysics Data System (ADS)

Cao, Guiping; Xia, Haojie; Dong, Ning

2018-05-01

The method commonly used to produce a field-programmable gate array (FPGA)-based time-to-digital converter (TDC) creates a tapped delay line (TDL) for time interpolation to yield high time precision. We conduct timing adjustment and bin realignment to implement a TDC in the Altera Cyclone-IV FPGA. The former tunes the carry look-up table (LUT) cell delay by changing the LUT's function through low-level primitives according to timing analysis results, while the latter realigns bins according to the timing result obtained by timing adjustment so as to create a uniform TDL with bins of equivalent width. The differential nonlinearity and time resolution can be improved by realigning the bins. After calibration, the TDC has a 18 ps root-mean-square timing resolution and a 45 ps least-significant bit resolution.

Averaging scheme for atomic resolution off-axis electron holograms.

PubMed

Niermann, T; Lehmann, M

2014-08-01

All micrographs are limited by shot-noise, which is intrinsic to the detection process of electrons. For beam insensitive specimen this limitation can in principle easily be circumvented by prolonged exposure times. However, in the high-resolution regime several instrumental instabilities limit the applicable exposure time. Particularly in the case of off-axis holography the holograms are highly sensitive to the position and voltage of the electron-optical biprism. We present a novel reconstruction algorithm to average series of off-axis holograms while compensating for specimen drift, biprism drift, drift of biprism voltage, and drift of defocus, which all might cause problematic changes from exposure to exposure. We show an application of the algorithm utilizing also the possibilities of double biprism holography, which results in a high quality exit-wave reconstruction with 75 pm resolution at a very high signal-to-noise ratio. Copyright © 2014 Elsevier Ltd. All rights reserved.

Improving resolution of crosswell seismic section based on time-frequency analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Luo, H.; Li, Y.

1994-12-31

According to signal theory, to improve resolution of seismic section is to extend high-frequency band of seismic signal. In cross-well section, sonic log can be regarded as a reliable source providing high-frequency information to the trace near the borehole. In such case, what to do is to introduce this high-frequency information into the whole section. However, neither traditional deconvolution algorithms nor some new inversion methods such as BCI (Broad Constraint Inversion) are satisfied because of high-frequency noise and nonuniqueness of inversion results respectively. To overcome their disadvantages, this paper presents a new algorithm based on Time-Frequency Analysis (TFA) technology whichmore » has been increasingly received much attention as an useful signal analysis too. Practical applications show that the new method is a stable scheme to improve resolution of cross-well seismic section greatly without decreasing Signal to Noise Ratio (SNR).« less

Reconstruction of high temporal resolution Thomson scattering data during a modulated electron cyclotron resonance heating using conditional averaging

NASA Astrophysics Data System (ADS)

Kobayashi, T.; Ida, K.; Itoh, K.; Yoshinuma, M.; Moon, C.; Inagaki, S.; Yamada, I.; Funaba, H.; Yasuhara, R.; Tsuchiya, H.; Ohdachi, S.; Yoshimura, Y.; Igami, H.; Shimozuma, T.; Kubo, S.; Tsujimura, T. I.

2016-04-01

This paper provides a software application of the sampling scope concept for fusion research. The time evolution of Thomson scattering data is reconstructed with a high temporal resolution during a modulated electron cyclotron resonance heating (MECH) phase. The amplitude profile and the delay time profile of the heat pulse propagation are obtained from the reconstructed signal for discharges having on-axis and off-axis MECH depositions. The results are found to be consistent with the MECH deposition.

Reconstruction of high temporal resolution Thomson scattering data during a modulated electron cyclotron resonance heating using conditional averaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kobayashi, T., E-mail: kobayashi.tatsuya@LHD.nifs.ac.jp; Yoshinuma, M.; Ohdachi, S.

2016-04-15

This paper provides a software application of the sampling scope concept for fusion research. The time evolution of Thomson scattering data is reconstructed with a high temporal resolution during a modulated electron cyclotron resonance heating (MECH) phase. The amplitude profile and the delay time profile of the heat pulse propagation are obtained from the reconstructed signal for discharges having on-axis and off-axis MECH depositions. The results are found to be consistent with the MECH deposition.

Reconstruction of high temporal resolution Thomson scattering data during a modulated electron cyclotron resonance heating using conditional averaging.

PubMed

Kobayashi, T; Ida, K; Itoh, K; Yoshinuma, M; Moon, C; Inagaki, S; Yamada, I; Funaba, H; Yasuhara, R; Tsuchiya, H; Ohdachi, S; Yoshimura, Y; Igami, H; Shimozuma, T; Kubo, S; Tsujimura, T I

2016-04-01

This paper provides a software application of the sampling scope concept for fusion research. The time evolution of Thomson scattering data is reconstructed with a high temporal resolution during a modulated electron cyclotron resonance heating (MECH) phase. The amplitude profile and the delay time profile of the heat pulse propagation are obtained from the reconstructed signal for discharges having on-axis and off-axis MECH depositions. The results are found to be consistent with the MECH deposition.

Low sidelobe level and high time resolution for metallic ultrasonic testing with linear-chirp-Golay coded excitation

NASA Astrophysics Data System (ADS)

Zhang, Jiaying; Gang, Tie; Ye, Chaofeng; Cong, Sen

2018-04-01

Linear-chirp-Golay (LCG)-coded excitation combined with pulse compression is proposed in this paper to improve the time resolution and suppress sidelobe in ultrasonic testing. The LCG-coded excitation is binary complementary pair Golay signal with linear-chirp signal applied on every sub pulse. Compared with conventional excitation which is a common ultrasonic testing method using a brief narrow pulse as exciting signal, the performances of LCG-coded excitation, in terms of time resolution improvement and sidelobe suppression, are studied via numerical and experimental investigations. The numerical simulations are implemented using Matlab K-wave toolbox. It is seen from the simulation results that time resolution of LCG excitation is 35.5% higher and peak sidelobe level (PSL) is 57.6 dB lower than linear-chirp excitation with 2.4 MHz chirp bandwidth and 3 μs time duration. In the B-scan experiment, time resolution of LCG excitation is higher and PSL is lower than conventional brief pulse excitation and chirp excitation. In terms of time resolution, LCG-coded signal has better performance than chirp signal. Moreover, the impact of chirp bandwidth on LCG-coded signal is less than that on chirp signal. In addition, the sidelobe of LCG-coded signal is lower than that of chirp signal with pulse compression.

Application of spatially resolved high resolution crystal spectrometry to inertial confinement fusion plasmas.

PubMed

Hill, K W; Bitter, M; Delgado-Aparacio, L; Pablant, N A; Beiersdorfer, P; Schneider, M; Widmann, K; Sanchez del Rio, M; Zhang, L

2012-10-01

High resolution (λ∕Δλ ∼ 10 000) 1D imaging x-ray spectroscopy using a spherically bent crystal and a 2D hybrid pixel array detector is used world wide for Doppler measurements of ion-temperature and plasma flow-velocity profiles in magnetic confinement fusion plasmas. Meter sized plasmas are diagnosed with cm spatial resolution and 10 ms time resolution. This concept can also be used as a diagnostic of small sources, such as inertial confinement fusion plasmas and targets on x-ray light source beam lines, with spatial resolution of micrometers, as demonstrated by laboratory experiments using a 250-μm (55)Fe source, and by ray-tracing calculations. Throughput calculations agree with measurements, and predict detector counts in the range 10(-8)-10(-6) times source x-rays, depending on crystal reflectivity and spectrometer geometry. Results of the lab demonstrations, application of the technique to the National Ignition Facility (NIF), and predictions of performance on NIF will be presented.

Smoothing and gap-filling of high resolution multi-spectral time series: Example of Landsat data

NASA Astrophysics Data System (ADS)

Vuolo, Francesco; Ng, Wai-Tim; Atzberger, Clement

2017-05-01

This paper introduces a novel methodology for generating 15-day, smoothed and gap-filled time series of high spatial resolution data. The approach is based on templates from high quality observations to fill data gaps that are subsequently filtered. We tested our method for one large contiguous area (Bavaria, Germany) and for nine smaller test sites in different ecoregions of Europe using Landsat data. Overall, our results match the validation dataset to a high degree of accuracy with a mean absolute error (MAE) of 0.01 for visible bands, 0.03 for near-infrared and 0.02 for short-wave-infrared. Occasionally, the reconstructed time series are affected by artefacts due to undetected clouds. Less frequently, larger uncertainties occur as a result of extended periods of missing data. Reliable cloud masks are highly warranted for making full use of time series.

Fast ultra-wideband microwave spectral scanning utilizing photonic wavelength- and time-division multiplexing.

PubMed

Li, Yihan; Kuse, Naoya; Fermann, Martin

2017-08-07

A high-speed ultra-wideband microwave spectral scanning system is proposed and experimentally demonstrated. Utilizing coherent dual electro-optical frequency combs and a recirculating optical frequency shifter, the proposed system realizes wavelength- and time-division multiplexing at the same time, offering flexibility between scan speed and size, weight and power requirements (SWaP). High-speed spectral scanning spanning from ~1 to 8 GHz with ~1.2 MHz spectral resolution is achieved experimentally within 14 µs. The system can be easily scaled to higher bandwidth coverage, faster scanning speed or finer spectral resolution with suitable hardware.

Three-dimensional optical coherence tomography of the embryonic murine cardiovascular system

NASA Astrophysics Data System (ADS)

Luo, Wei; Marks, Daniel L.; Ralston, Tyler S.; Boppart, Stephen A.

2006-03-01

Optical coherence tomography (OCT) is an emerging high-resolution real-time biomedical imaging technology that has potential as a novel investigational tool in developmental biology and functional genomics. In this study, murine embryos and embryonic hearts are visualized with an OCT system capable of 2-µm axial and 15-µm lateral resolution and with real-time acquisition rates. We present, to our knowledge, the first sets of high-resolution 2- and 3-D OCT images that reveal the internal structures of the mammalian (murine) embryo (E10.5) and embryonic (E14.5 and E17.5) cardiovascular system. Strong correlations are observed between OCT images and corresponding hematoxylin- and eosin-stained histological sections. Real-time in vivo embryonic (E10.5) heart activity is captured by spectral-domain optical coherence tomography, processed, and displayed at a continuous rate of five frames per second. With the ability to obtain not only high-resolution anatomical data but also functional information during cardiovascular development, the OCT technology has the potential to visualize and quantify changes in murine development and in congenital and induced heart disease, as well as enable a wide range of basic in vitro and in vivo research studies in functional genomics.

EUNIS; Extreme-Ultraviolet Normal-Incidence Spectrometer

NASA Technical Reports Server (NTRS)

Thomas, Roger J.; Davila, Joseph M.; Fisher, Richard R. (Technical Monitor)

2001-01-01

GSFC is in the process of assembling an Extreme-Ultraviolet Normal Incidence Spectrometer called EUNIS, to be flown as a sounding rocket payload. The instrument builds on the many technical innovations pioneered by our highly successful SERTS experiment, which has now flown a total of ten times, most recently last summer. The new design will have somewhat improved spatial and spectral resolutions, as well as two orders of magnitude greater sensitivity, permitting high signal/noise EUV spectroscopy with a temporal resolution near 1 second for the first time ever. In order to achieve such high time cadence, a novel detector system is being developed, based on Active-Pixel-Sensor electronics, a key component of our design.

Fast high resolution reconstruction in multi-slice and multi-view cMRI

NASA Astrophysics Data System (ADS)

Velasco Toledo, Nelson; Romero Castro, Eduardo

2015-01-01

Cardiac magnetic resonance imaging (cMRI) is an useful tool in diagnosis, prognosis and research since it functionally tracks the heart structure. Although useful, this imaging technique is limited in spatial resolution because heart is a constant moving organ, also there are other non controled conditions such as patient movements and volumetric changes during apnea periods when data is acquired, those conditions limit the time to capture high quality information. This paper presents a very fast and simple strategy to reconstruct high resolution 3D images from a set of low resolution series of 2D images. The strategy is based on an information reallocation algorithm which uses the DICOM header to relocate voxel intensities in a regular grid. An interpolation method is applied to fill empty places with estimated data, the interpolation resamples the low resolution information to estimate the missing information. As a final step a gaussian filter that denoises the final result. A reconstructed image evaluation is performed using as a reference a super-resolution reconstructed image. The evaluation reveals that the method maintains the general heart structure with a small loss in detailed information (edge sharpening and blurring), some artifacts related with input information quality are detected. The proposed method requires low time and computational resources.

Above-real-time training (ARTT) improves transfer to a simulated flight control task.

PubMed

Donderi, D C; Niall, Keith K; Fish, Karyn; Goldstein, Benjamin

2012-06-01

The aim of this study was to measure the effects of above-real-time-training (ARTT) speed and screen resolution on a simulated flight control task. ARTT has been shown to improve transfer to the criterion task in some military simulation experiments. We tested training speed and screen resolution in a project, sponsored by Defence Research and Development Canada, to develop components for prototype air mission simulators. For this study, 54 participants used a single-screen PC-based flight simulation program to learn to chase and catch an F-18A fighter jet with another F-18A while controlling the chase aircraft with a throttle and side-stick controller. Screen resolution was varied between participants, and training speed was varied factorially across two sessions within participants. Pretest and posttest trials were at high resolution and criterion (900 knots) speed. Posttest performance was best with high screen resolution training and when one ARTT training session was followed by a session of criterion speed training. ARTT followed by criterion training improves performance on a visual-motor coordination task. We think that ARTT influences known facilitators of transfer, including similarity to the criterion task and contextual interference. Use high-screen resolution, start with ARTT, and finish with criterion speed training when preparing a mission simulation.

Integrating real-time and manual monitored data to predict hillslope soil moisture dynamics with high spatio-temporal resolution using linear and non-linear models

USDA-ARS?s Scientific Manuscript database

Spatio-temporal variability of soil moisture (') is a challenge that remains to be better understood. A trade-off exists between spatial coverage and temporal resolution when using the manual and real-time ' monitoring methods. This restricted the comprehensive and intensive examination of ' dynamic...

High resolution time of arrival estimation for a cooperative sensor system

NASA Astrophysics Data System (ADS)

Morhart, C.; Biebl, E. M.

2010-09-01

Distance resolution of cooperative sensors is limited by the signal bandwidth. For the transmission mainly lower frequency bands are used which are more narrowband than classical radar frequencies. To compensate this resolution problem the combination of a pseudo-noise coded pulse compression system with superresolution time of arrival estimation is proposed. Coded pulsecompression allows secure and fast distance measurement in multi-user scenarios which can easily be adapted for data transmission purposes (Morhart and Biebl, 2009). Due to the lack of available signal bandwidth the measurement accuracy degrades especially in multipath scenarios. Superresolution time of arrival algorithms can improve this behaviour by estimating the channel impulse response out of a band-limited channel view. For the given test system the implementation of a MUSIC algorithm permitted a two times better distance resolution as the standard pulse compression.

High-Resolution Time-Lapse Monitoring of Unsaturated Flow using Automated GPR Data Collection

NASA Astrophysics Data System (ADS)

Mangel, A. R.; Moysey, S. M.; Lytle, B. A.; Bradford, J. H.

2015-12-01

High-resolution ground-penetrating radar (GPR) data provide the detailed information required to image subsurface structures. Recent advances in GPR monitoring now also make it possible to study transient hydrologic processes, but high-speed data acquisition is critical for this application. We therefore highlight the capabilities of our automated system to acquire time-lapse, high-resolution multifold GPR data during infiltration of water into soils. The system design allows for fast acquisition of constant-offset (COP) and common-midpoint profiles (CMP) to monitor unsaturated flow at multiple locations. Qualitative interpretation of the unprocessed COPs can provide substantial information regarding the hydrologic response of the system, such as the complexities of patterns associated with the wetting of the soil and geophysical evidence of non-uniform propagation of a wetting front. While we find that unprocessed images are informative, we show that the spatial variability of velocity introduced by infiltration events can complicate the images and that migration of the data is an effective tool to improve interpretability of the time-lapse images. The ability of the system to collect high density CMP data also introduces the potential for improving the velocity model along with the image via reflection tomography in the post-migrated domain. We show that for both simulated and empirical time-lapse GPR profiles we can resolve a propagating wetting front in the soil that is in good agreement with the response of in-situ soil moisture measurements. The data from these experiments illustrate the importance of high-speed, high-resolution GPR data acquisition for obtaining insight about the dynamics of hydrologic events. Continuing research is aimed at improving the quantitative analysis of surface-based GPR monitoring data for identifying preferential flow in soils.

Multi-beam laser altimeter

NASA Technical Reports Server (NTRS)

Bufton, Jack L.; Harding, David J.; Ramos-Izquierdo, Luis

1993-01-01

Laser altimetry provides a high-resolution, high-accuracy method for measurement of the elevation and horizontal variability of Earth-surface topography. The basis of the measurement is the timing of the round-trip propagation of short-duration pulses of laser radiation between a spacecraft and the Earth's surface. Vertical resolution of the altimetry measurement is determined primarily by laser pulsewidth, surface-induced spreading in time of the reflected pulse, and the timing precision of the altimeter electronics. With conventional gain-switched pulses from solid-state lasers and sub-nsec resolution electronics, sub-meter vertical range resolution is possible from orbital attitudes of several hundred kilometers. Horizontal resolution is a function of laser beam footprint size at the surface and the spacing between successive laser pulses. Laser divergence angle and altimeter platform height above the surface determine the laser footprint size at the surface, while laser pulse repetition-rate, laser transmitter beam configuration, and altimeter platform velocity determine the space between successive laser pulses. Multiple laser transitters in a singlaltimeter instrument provide across-track and along-track coverage that can be used to construct a range image of the Earth's surface. Other aspects of the multi-beam laser altimeter are discussed.

Real Time Monitoring of Flooding from Microwave Satellite Observations

NASA Technical Reports Server (NTRS)

Galantowicz, John F.; Frey, Herb (Technical Monitor)

2002-01-01

We have developed a new method for making high-resolution flood extent maps (e.g., at the 30-100 m scale of digital elevation models) in real-time from low-resolution (20-70 km) passive microwave observations. The method builds a "flood-potential" database from elevations and historic flood imagery and uses it to create a flood-extent map consistent with the observed open water fraction. Microwave radiometric measurements are useful for flood monitoring because they sense surface water in clear-or-cloudy conditions and can provide more timely data (e.g., compared to radars) from relatively wide swath widths and an increasing number of available platforms (DMSP, ADEOS-II, Terra, NPOESS, GPM). The chief disadvantages for flood mapping are the radiometers' low resolution and the need for local calibration of the relationship between radiances and open-water fraction. We present our method for transforming microwave sensor-scale open water fraction estimates into high-resolution flood extent maps and describe 30-day flood map sequences generated during a retrospective study of the 1993 Great Midwest Flood. We discuss the method's potential improvement through as yet unimplemented algorithm enhancements and expected advancements in microwave radiometry (e.g., improved resolution and atmospheric correction).

The silicon drift detector for the IXO high-time resolution spectrometer

NASA Astrophysics Data System (ADS)

Lechner, Peter; Amoros, Carine; Barret, Didier; Bodin, Pierre; Boutelier, Martin; Eckhardt, Rouven; Fiorini, Carlo; Kendziorra, Eckhard; Lacombe, Karine; Niculae, Adrian; Pouilloux, Benjamin; Pons, Roger; Rambaud, Damien; Ravera, Laurent; Schmid, Christian; Soltau, Heike; Strüder, Lothar; Tenzer, Christoph; Wilms, Jörn

2010-07-01

The High Time Resolution Spectrometer (HTRS) is one of six scientific payload instruments of the International X-ray Observatory (IXO). HTRS is dedicated to the physics of matter at extreme density and gravity and will observe the X-rays generated in the inner accretion flows around the most compact massive objects, i.e. black holes and neutron stars. The study of their timing signature and in addition the simultaneous spectroscopy of the gravitationally shifted and broadened iron line allows for probing general relativity in the strong field regime and understanding the inner structure of neutron stars. As the sources to be observed by HTRS are the brightest in the X-ray sky and the studies require good photon statistics the instrument design is driven by the capability to operate at extremely high count rates. The HTRS instrument is based on a monolithic array of Silicon Drift Detectors (SDDs) with 31 cells in a circular envelope and a sensitive volume of 4.5 cm2 × 450 μm. The SDD principle uses fast signal charge collection on an integrated amplifier by a focusing internal electrical field. It combines a large sensitive area and a small capacitance, thus facilitating good energy resolution and high count rate capability. The HTRS is specified to provide energy spectra with a resolution of 150 eV (FWHM at 6 keV) at high time resolution of 10 μsec and with high count rate capability up to a goal of 2.106 counts per second, corresponding to a 12 Crab equivalent source. As the HTRS is a non-imaging instrument and will target only point sources it is placed on axis but out of focus so that the spot is spread over the array of 31 SDD cells. The SDD array is logically organized in four independent 'quadrants', a dedicated 8-channel quadrant readout chip is in development.

Correlation spectrometer for filtering of (quasi) elastic neutron scattering with variable resolution

NASA Astrophysics Data System (ADS)

Magazù, Salvatore; Mezei, Ferenc; Migliardo, Federica

2018-05-01

In a variety of applications of inelastic neutron scattering spectroscopy the goal is to single out the elastic scattering contribution from the total scattered spectrum as a function of momentum transfer and sample environment parameters. The elastic part of the spectrum is defined in such a case by the energy resolution of the spectrometer. Variable elastic energy resolution offers a way to distinguish between elastic and quasi-elastic intensities. Correlation spectroscopy lends itself as an efficient, high intensity approach for accomplishing this both at continuous and pulsed neutron sources. On the one hand, in beam modulation methods the Liouville theorem coupling between intensity and resolution is relaxed and time-of-flight velocity analysis of the neutron velocity distribution can be performed with 50 % duty factor exposure for all available resolutions. On the other hand, the (quasi)elastic part of the spectrum generally contains the major part of the integrated intensity at a given detector, and thus correlation spectroscopy can be applied with most favorable signal to statistical noise ratio. The novel spectrometer CORELLI at SNS is an example for this type of application of the correlation technique at a pulsed source. On a continuous neutron source a statistical chopper can be used for quasi-random time dependent beam modulation and the total time-of-flight of the neutron from the statistical chopper to detection is determined by the analysis of the correlation between the temporal fluctuation of the neutron detection rate and the statistical chopper beam modulation pattern. The correlation analysis can either be used for the determination of the incoming neutron velocity or for the scattered neutron velocity, depending of the position of the statistical chopper along the neutron trajectory. These two options are considered together with an evaluation of spectrometer performance compared to conventional spectroscopy, in particular for variable resolution elastic neutron scattering (RENS) studies of relaxation processes and the evolution of mean square displacements. A particular focus of our analysis is the unique feature of correlation spectroscopy of delivering high and resolution independent beam intensity, thus the same statistical chopper scan contains both high intensity and high resolution information at the same time, and can be evaluated both ways. This flexibility for variable resolution data handling represents an additional asset for correlation spectroscopy in variable resolution work. Changing the beam width for the same statistical chopper allows us to additionally trade resolution for intensity in two different experimental runs, similarly for conventional single slit chopper spectroscopy. The combination of these two approaches is a capability of particular value in neutron spectroscopy studies requiring variable energy resolution, such as the systematic study of quasi-elastic scattering and mean square displacement. Furthermore the statistical chopper approach is particularly advantageous for studying samples with low scattering intensity in the presence of a high, sample independent background.

High-resolution photo-mosaic time-series imagery for monitoring human use of an artificial reef.

PubMed

Wood, Georgina; Lynch, Tim P; Devine, Carlie; Keller, Krystle; Figueira, Will

2016-10-01

Successful marine management relies on understanding patterns of human use. However, obtaining data can be difficult and expensive given the widespread and variable nature of activities conducted. Remote camera systems are increasingly used to overcome cost limitations of conventional labour-intensive methods. Still, most systems face trade-offs between the spatial extent and resolution over which data are obtained, limiting their application. We trialed a novel methodology, CSIRO Ruggedized Autonomous Gigapixel System (CRAGS), for time series of high-resolution photo-mosaic (HRPM) imagery to estimate fine-scale metrics of human activity at an artificial reef located 1.3 km from shore. We compared estimates obtained using the novel system to those produced with a web camera that concurrently monitored the site. We evaluated the effect of day type (weekday/weekend) and time of day on each of the systems and compared to estimates obtained from binocular observations. In general, both systems delivered similar estimates for the number of boats observed and to those obtained by binocular counts; these results were also unaffected by the type of day (weekend vs. weekday). CRAGS was able to determine additional information about the user type and party size that was not possible with the lower resolution webcam system. However, there was an effect of time of day as CRAGS suffered from poor image quality in early morning conditions as a result of fixed camera settings. Our field study provides proof of concept of use of this new cost-effective monitoring tool for the remote collection of high-resolution large-extent data on patterns of human use at high temporal frequency.

GLAST Burst Monitor Signal Processing System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhat, P. Narayana; Briggs, Michael; Connaughton, Valerie

The onboard Data Processing Unit (DPU), designed and built by Southwest Research Institute, performs the high-speed data acquisition for GBM. The analog signals from each of the 14 detectors are digitized by high-speed multichannel analog data acquisition architecture. The streaming digital values resulting from a periodic (period of 104.2 ns) sampling of the analog signal by the individual ADCs are fed to a Field-Programmable Gate Array (FPGA). Real-time Digital Signal Processing (DSP) algorithms within the FPGA implement functions like filtering, thresholding, time delay and pulse height measurement. The spectral data with a 12-bit resolution are formatted according to the commandablemore » look-up-table (LUT) and then sent to the High-Speed Science-Date Bus (HSSDB, speed=1.5 MB/s) to be telemetered to ground. The DSP offers a novel feature of a commandable and constant event deadtime. The ADC non-linearities have been calibrated so that the spectral data can be corrected during analysis. The best temporal resolution is 2 {mu}s for the pre-burst and post-trigger time-tagged events (TTE) data. The time resolution of the binned data types is commandable from 64 msec to 1.024 s for the CTIME data (8 channel spectral resolution) and 1.024 to 32.768 s for the CSPEC data (128 channel spectral resolution). The pulse pile-up effects have been studied by Monte Carlo simulations. For a typical GRB, the possible shift in the Epeak value at high-count rates ({approx}100 kHz) is {approx}1% while the change in the single power-law index could be up to 5%.« less

Large Observatory for x-ray Timing (LOFT-P): a Probe-class mission concept study

NASA Astrophysics Data System (ADS)

Wilson-Hodge, Colleen A.; Ray, Paul S.; Chakrabarty, Deepto; Feroci, Marco; Alvarez, Laura; Baysinger, Michael; Becker, Chris; Bozzo, Enrico; Brandt, Soren; Carson, Billy; Chapman, Jack; Dominguez, Alexandra; Fabisinski, Leo; Gangl, Bert; Garcia, Jay; Griffith, Christopher; Hernanz, Margarita; Hickman, Robert; Hopkins, Randall; Hui, Michelle; Ingram, Luster; Jenke, Peter; Korpela, Seppo; Maccarone, Tom; Michalska, Malgorzata; Pohl, Martin; Santangelo, Andrea; Schanne, Stephane; Schnell, Andrew; Stella, Luigi; van der Klis, Michiel; Watts, Anna; Winter, Berend; Zane, Silvia

2016-07-01

LOFT-P is a mission concept for a NASA Astrophysics Probe-Class (<$1B) X-ray timing mission, based on the LOFT M-class concept originally proposed to ESAs M3 and M4 calls. LOFT-P requires very large collecting area, high time resolution, good spectral resolution, broad-band spectral coverage (2-30 keV), highly flexible scheduling, and an ability to detect and respond promptly to time-critical targets of opportunity. It addresses science questions such as: What is the equation of state of ultra dense matter? What are the effects of strong gravity on matter spiraling into black holes? It would be optimized for sub-millisecond timing of bright Galactic X-ray sources including X-ray bursters, black hole binaries, and magnetars to study phenomena at the natural timescales of neutron star surfaces and black hole event horizons and to measure mass and spin of black holes. These measurements are synergistic to imaging and high-resolution spectroscopy instruments, addressing much smaller distance scales than are possible without very long baseline X-ray interferometry, and using complementary techniques to address the geometry and dynamics of emission regions. LOFT-P would have an effective area of >6 m2, > 10x that of the highly successful Rossi X-ray Timing Explorer (RXTE). A sky monitor (2-50 keV) acts as a trigger for pointed observations, providing high duty cycle, high time resolution monitoring of the X-ray sky with 20 times the sensitivity of the RXTE All-Sky Monitor, enabling multi-wavelength and multimessenger studies. A probe-class mission concept would employ lightweight collimator technology and large-area solid-state detectors, segmented into pixels or strips, technologies which have been recently greatly advanced during the ESA M3 Phase A study of LOFT. Given the large community interested in LOFT (>800 supporters*, the scientific productivity of this mission is expected to be very high, similar to or greater than RXTE ( 2000 refereed publications). We describe the results of a study, recently completed by the MSFC Advanced Concepts Office, that demonstrates that such a mission is feasible within a NASA probe-class mission budget.

Beam modulation: A novel ToF-technique for high resolution diffraction at the Beamline for European Materials Engineering Research (BEER)

NASA Astrophysics Data System (ADS)

Rouijaa, M.; Kampmann, R.; Šaroun, J.; Fenske, J.; Beran, P.; Müller, M.; Lukáš, P.; Schreyer, A.

2018-05-01

The Beamline for European Materials Engineering Research (BEER) is under construction at the European Spallation Source (ESS) in Lund, Sweden. A basic requirement on BEER is to make best use of the long ESS pulse (2.86 ms) for engineering investigations. High-resolution diffraction, however, demands timing resolution up to 0.1% corresponding to a pulse length down to about 70 μs for the case of thermal neutrons (λ ∼ 1.8 Å). Such timing resolution can be achieved by pulse shaping techniques cutting a short section out of the long pulse, and thus paying for resolution by strong loss of intensity. In contrast to this, BEER proposes a novel operation mode called pulse modulation technique based on a new chopper design, which extracts several short pulses out of the long ESS pulse, and hence leads to a remarkable gain of intensity compared to nowadays existing conventional pulse shaping techniques. The potential of the new technique can be used with full advantage for investigating strains and textures of highly symmetric materials. Due to its instrument design and the high brilliance of the ESS pulse, BEER is expected to become the European flagship for engineering research for strain mapping and texture analysis.

Three-Dimensional Terahertz Coded-Aperture Imaging Based on Single Input Multiple Output Technology.

PubMed

Chen, Shuo; Luo, Chenggao; Deng, Bin; Wang, Hongqiang; Cheng, Yongqiang; Zhuang, Zhaowen

2018-01-19

As a promising radar imaging technique, terahertz coded-aperture imaging (TCAI) can achieve high-resolution, forward-looking, and staring imaging by producing spatiotemporal independent signals with coded apertures. In this paper, we propose a three-dimensional (3D) TCAI architecture based on single input multiple output (SIMO) technology, which can reduce the coding and sampling times sharply. The coded aperture applied in the proposed TCAI architecture loads either purposive or random phase modulation factor. In the transmitting process, the purposive phase modulation factor drives the terahertz beam to scan the divided 3D imaging cells. In the receiving process, the random phase modulation factor is adopted to modulate the terahertz wave to be spatiotemporally independent for high resolution. Considering human-scale targets, images of each 3D imaging cell are reconstructed one by one to decompose the global computational complexity, and then are synthesized together to obtain the complete high-resolution image. As for each imaging cell, the multi-resolution imaging method helps to reduce the computational burden on a large-scale reference-signal matrix. The experimental results demonstrate that the proposed architecture can achieve high-resolution imaging with much less time for 3D targets and has great potential in applications such as security screening, nondestructive detection, medical diagnosis, etc.

3D detectors with high space and time resolution

NASA Astrophysics Data System (ADS)

Loi, A.

2018-01-01

For future high luminosity LHC experiments it will be important to develop new detector systems with increased space and time resolution and also better radiation hardness in order to operate in high luminosity environment. A possible technology which could give such performances is 3D silicon detectors. This work explores the possibility of a pixel geometry by designing and simulating different solutions, using Sentaurus Tecnology Computer Aided Design (TCAD) as design and simulation tool, and analysing their performances. A key factor during the selection was the generated electric field and the carrier velocity inside the active area of the pixel.

Applications of nanopipettes in bionanotechnology.

PubMed

Ying, Liming

2009-08-01

At present, technical hurdles remain in probing biochemical processes in living cells and organisms at nanometre spatial resolution, millisecond time resolution and with high specificity and single-molecule sensitivity. Owing to its unique shape, size and electrical properties, the nanopipette has been used to obtain high-resolution topographic images of live cells under physiological conditions, and to create nanoscale features by controlled delivery of biomolecules. In the present paper, I discuss recent progress in the development of a family of new methods for nanosensing and nanomanipulation using nanopipettes.

High resolution, wide field of view, real time 340GHz 3D imaging radar for security screening

NASA Astrophysics Data System (ADS)

Robertson, Duncan A.; Macfarlane, David G.; Hunter, Robert I.; Cassidy, Scott L.; Llombart, Nuria; Gandini, Erio; Bryllert, Tomas; Ferndahl, Mattias; Lindström, Hannu; Tenhunen, Jussi; Vasama, Hannu; Huopana, Jouni; Selkälä, Timo; Vuotikka, Antti-Jussi

2017-05-01

The EU FP7 project CONSORTIS (Concealed Object Stand-Off Real-Time Imaging for Security) is developing a demonstrator system for next generation airport security screening which will combine passive and active submillimeter wave imaging sensors. We report on the development of the 340 GHz 3D imaging radar which achieves high volumetric resolution over a wide field of view with high dynamic range and a high frame rate. A sparse array of 16 radar transceivers is coupled with high speed mechanical beam scanning to achieve a field of view of 1 x 1 x 1 m3 and a 10 Hz frame rate.

APES: Acute Precipitating Electron Spectrometer - A High Time Resolution Monodirectional Magnetic Deflection Electron Spectrometer

NASA Technical Reports Server (NTRS)

Michell, R. G.; Samara, M.; Grubbs, G., II; Ogasawara, K.; Miller, G.; Trevino, J. A.; Webster, J.; Stange, J.

2016-01-01

We present a description of the Acute Precipitating Electron Spectrometer (APES) that was designed and built for the Ground-to-Rocket Electron Electrodynamics Correlative Experiment (GREECE) auroral sounding rocket mission. The purpose was to measure the precipitating electron spectrum with high time resolution, on the order of milliseconds. The trade-off made in order to achieve high time resolution was to limit the aperture to only one look direction. The energy selection was done by using a permanent magnet to separate the incoming electrons, such that the different energies would fall onto different regions of the microchannel plate and therefore be detected by different anodes. A rectangular microchannel plate (MCP) was used (15 mm x 100 mm), and there was a total of 50 discrete anodes under the MCP, each one 15 mm x 1.5 mm, with a 0.5 mm spacing between anodes. The target energy range of APES was 200 eV to 30 keV.

High-resolution clustered pinhole (131)Iodine SPECT imaging in mice.

PubMed

van der Have, Frans; Ivashchenko, Oleksandra; Goorden, Marlies C; Ramakers, Ruud M; Beekman, Freek J

2016-08-01

High-resolution pre-clinical (131)I SPECT can facilitate development of new radioiodine therapies for cancer. To this end, it is important to limit resolution-degrading effects of pinhole edge penetration by the high-energy γ-photons of iodine. Here we introduce, optimize and validate (131)I SPECT performed with a dedicated high-energy clustered multi-pinhole collimator. A SPECT-CT system (VECTor/CT) with stationary gamma-detectors was equipped with a tungsten collimator with clustered pinholes. Images were reconstructed with pixel-based OSEM, using a dedicated (131)I system matrix that models the distance- and energy-dependent resolution and sensitivity of each pinhole, as well as the intrinsic detector blurring and variable depth of interaction in the detector. The system performance was characterized with phantoms and in vivo static and dynamic (131)I-NaI scans of mice. Reconstructed image resolution reached 0.6mm, while quantitative accuracy measured with a (131)I filled syringe reaches an accuracy of +3.6±3.5% of the gold standard value. In vivo mice scans illustrated a clear shape of the thyroid and biodistribution of (131)I within the animal. Pharmacokinetics of (131)I was assessed with 15-s time frames from the sequence of dynamic images and time-activity curves of (131)I-NaI. High-resolution quantitative and fast dynamic (131)I SPECT in mice is possible by means of a high-energy collimator and optimized system modeling. This enables analysis of (131)I uptake even within small organs in mice, which can be highly valuable for development and optimization of targeted cancer therapies. Copyright © 2016 Elsevier Inc. All rights reserved.

High-Resolution Land Use and Land Cover Mapping

USGS Publications Warehouse

,

1999-01-01

As the Nation?s population grows, quantifying, monitoring, and managing land use becomes increasingly important. The U.S. Geological Survey (USGS) has a long heritage of leadership and innovation in land use and land cover (LULC) mapping that has been the model both nationally and internationally for over 20 years. At present, the USGS is producing high-resolution LULC data for several watershed and urban areas within the United States. This high-resolution LULC mapping is part of an ongoing USGS Land Cover Characterization Program (LCCP). The four components of the LCCP are global (1:2,000,000-scale), national (1:100,000-scale), urban (1:24,000-scale), and special projects (various scales and time periods). Within the urban and special project components, the USGS Rocky Mountain Mapping Center (RMMC) is collecting historical as well as contemporary high-resolution LULC data. RMMC?s high-resolution LULC mapping builds on the heritage and success of previous USGS LULC programs and provides LULC information to meet user requirements.

Per-Pixel Coded Exposure for High-Speed and High-Resolution Imaging Using a Digital Micromirror Device Camera

PubMed Central

Feng, Wei; Zhang, Fumin; Qu, Xinghua; Zheng, Shiwei

2016-01-01

High-speed photography is an important tool for studying rapid physical phenomena. However, low-frame-rate CCD (charge coupled device) or CMOS (complementary metal oxide semiconductor) camera cannot effectively capture the rapid phenomena with high-speed and high-resolution. In this paper, we incorporate the hardware restrictions of existing image sensors, design the sampling functions, and implement a hardware prototype with a digital micromirror device (DMD) camera in which spatial and temporal information can be flexibly modulated. Combined with the optical model of DMD camera, we theoretically analyze the per-pixel coded exposure and propose a three-element median quicksort method to increase the temporal resolution of the imaging system. Theoretically, this approach can rapidly increase the temporal resolution several, or even hundreds, of times without increasing bandwidth requirements of the camera. We demonstrate the effectiveness of our method via extensive examples and achieve 100 fps (frames per second) gain in temporal resolution by using a 25 fps camera. PMID:26959023

Per-Pixel Coded Exposure for High-Speed and High-Resolution Imaging Using a Digital Micromirror Device Camera.

PubMed

Feng, Wei; Zhang, Fumin; Qu, Xinghua; Zheng, Shiwei

2016-03-04

High-speed photography is an important tool for studying rapid physical phenomena. However, low-frame-rate CCD (charge coupled device) or CMOS (complementary metal oxide semiconductor) camera cannot effectively capture the rapid phenomena with high-speed and high-resolution. In this paper, we incorporate the hardware restrictions of existing image sensors, design the sampling functions, and implement a hardware prototype with a digital micromirror device (DMD) camera in which spatial and temporal information can be flexibly modulated. Combined with the optical model of DMD camera, we theoretically analyze the per-pixel coded exposure and propose a three-element median quicksort method to increase the temporal resolution of the imaging system. Theoretically, this approach can rapidly increase the temporal resolution several, or even hundreds, of times without increasing bandwidth requirements of the camera. We demonstrate the effectiveness of our method via extensive examples and achieve 100 fps (frames per second) gain in temporal resolution by using a 25 fps camera.

High sensitivity far infrared laser diagnostics for the C-2U advanced beam-driven field-reversed configuration plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deng, B. H., E-mail: bdeng@trialphaenergy.com; Beall, M.; Schroeder, J.

2016-11-15

A high sensitivity multi-channel far infrared laser diagnostics with switchable interferometry and polarimetry operation modes for the advanced neutral beam-driven C-2U field-reversed configuration (FRC) plasmas is described. The interferometer achieved superior resolution of 1 × 10{sup 16} m{sup −2} at >1.5 MHz bandwidth, illustrated by measurement of small amplitude high frequency fluctuations. The polarimetry achieved 0.04° instrument resolution and 0.1° actual resolution in the challenging high density gradient environment with >0.5 MHz bandwidth, making it suitable for weak internal magnetic field measurements in the C-2U plasmas, where the maximum Faraday rotation angle is less than 1°. The polarimetry resolution datamore » is analyzed, and high resolution Faraday rotation data in C-2U is presented together with direct evidences of field reversal in FRC magnetic structure obtained for the first time by a non-perturbative method.« less

A streak camera based fiber optic pulsed polarimetry technique for magnetic sensing to sub-mm resolution.

PubMed

Smith, R J; Weber, T E

2016-11-01

The technique of fiber optic pulsed polarimetry, which provides a distributed (local) measurement of the magnetic field along an optical fiber, has been improved to the point where, for the first time, photocathode based optical detection of backscatter is possible with sub-mm spatial resolutions. This has been realized through the writing of an array of deterministic fiber Bragg gratings along the fiber, a so-called backscatter-tailored optical fiber, producing a 34 000-fold increase in backscatter levels over Rayleigh. With such high backscatter levels, high repetition rate lasers are now sufficiently bright to allow near continuous field sensing in both space and time with field resolutions as low as 0.005 T and as high as 170 T over a ∼mm interval given available fiber materials.

Harmonium: A pulse preserving source of monochromatic extreme ultraviolet (30-110 eV) radiation for ultrafast photoelectron spectroscopy of liquids.

PubMed

Ojeda, J; Arrell, C A; Grilj, J; Frassetto, F; Mewes, L; Zhang, H; van Mourik, F; Poletto, L; Chergui, M

2016-03-01

A tuneable repetition rate extreme ultraviolet source (Harmonium) for time resolved photoelectron spectroscopy of liquids is presented. High harmonic generation produces 30-110 eV photons, with fluxes ranging from ∼2 × 10(11) photons/s at 36 eV to ∼2 × 10(8) photons/s at 100 eV. Four different gratings in a time-preserving grating monochromator provide either high energy resolution (0.2 eV) or high temporal resolution (40 fs) between 30 and 110 eV. Laser assisted photoemission was used to measure the temporal response of the system. Vibrational progressions in gas phase water were measured demonstrating the ∼0.2 eV energy resolution.

A High-Resolution Speleothem Record From Florida of Atmospheric Teleconnections Since 1,500 Years Ago

NASA Astrophysics Data System (ADS)

Polk, J. S.; van Beynen, P.; Asmerom, Y.

2008-12-01

Understanding atmospheric teleconnections between tropical, subtropical, and higher-latitude regions of the North Atlantic Ocean is necessary to better evaluate the anthropogenic contribution to climate change. Here, we present a precisely dated, high- resolution speleothem record of stable isotopes and trace elements from Florida spanning the last 1,500 years. By using a multi-proxy approach, the different climatic influences were deconvolved, including the NAO, ENSO, PDO, and ITCZ, which all can affect our region. Further comparison using time-series analysis between our data and other high-resolution records covering this same period reveal differing influences of these teleconnections on geographic regions. Our record shows both the influence of changing rainfall above the cave and the influence of sea surface temperatures on atmospheric convection caused by atmospheric-oceanic variability over time.

MWIR imaging spectrometer with digital time delay integration for remote sensing and characterization of solar system objects

NASA Astrophysics Data System (ADS)

Kendrick, Stephen E.; Harwit, Alex; Kaplan, Michael; Smythe, William D.

2007-09-01

An MWIR TDI (Time Delay and Integration) Imager and Spectrometer (MTIS) instrument for characterizing from orbit the moons of Jupiter and Saturn is proposed. Novel to this instrument is the planned implementation of a digital TDI detector array and an innovative imaging/spectroscopic architecture. Digital TDI enables a higher SNR for high spatial resolution surface mapping of Titan and Enceladus and for improved spectral discrimination and resolution at Europa. The MTIS imaging/spectroscopic architecture combines a high spatial resolution coarse wavelength resolution imaging spectrometer with a hyperspectral sensor to spectrally decompose a portion of the data adjacent to the data sampled in the imaging spectrometer. The MTIS instrument thus maps with high spatial resolution a planetary object while spectrally decomposing enough of the data that identification of the constituent materials is highly likely. Additionally, digital TDI systems have the ability to enable the rejection of radiation induced spikes in high radiation environments (Europa) and the ability to image in low light levels (Titan and Enceladus). The ability to image moving objects that might be missed utilizing a conventional TDI system is an added advantage and is particularly important for characterizing atmospheric effects and separating atmospheric and surface components. This can be accomplished with on-orbit processing or collecting and returning individual non co-added frames.

Imaging of patients with hippocampal sclerosis at 7 Tesla: initial results.

PubMed

Breyer, Tobias; Wanke, Isabel; Maderwald, Stefan; Woermann, Friedrich G; Kraff, Oliver; Theysohn, Jens M; Ebner, Alois; Forsting, Michael; Ladd, Mark E; Schlamann, Marc

2010-04-01

Focal epilepsies potentially can be cured by neurosurgery; other treatment options usually remain symptomatic. High-resolution magnetic resonance (MR) imaging is the central imaging strategy in the evaluation of focal epilepsy. The most common substrate of temporal epilepsies is hippocampal sclerosis (HS), which cannot always be sufficiently characterized with current MR field strengths. Therefore, the purpose of our study was to demonstrate the feasibility of high-resolution MR imaging at 7 Tesla in patients with focal epilepsy resulting from a HS and to improve image resolution at 7 Tesla in patients with HS. Six patients with known HS were investigated with T1-, T2-, T2(*)-, and fluid-attenuated inversion recovery-weighted sequences at 7 Tesla with an eight-channel transmit-receive head coil. Total imaging time did not exceed 90 minutes per patient. High-resolution imaging at 7 Tesla is feasible and reveals high resolution of intrahippocampal structures in vivo. HS was confirmed in all patients. The maximum non-interpolated in-plane resolution reached 0.2 x 0.2 mm(2) in T2(*)-weighted images. The increased susceptibility effects at 7 Tesla revealed identification of intrahippocampal structures in more detail than at 1.5 Tesla, but otherwise led to stronger artifacts. Imaging revealed regional differences in hippocampal atrophy between patients. The scan volume was limited because of specific absorption rate restrictions, scanning time was reasonable. High-resolution imaging at 7 Tesla is promising in presurgical epilepsy imaging. "New" contrasts may further improve detection of even very small intrahippocampal structural changes. Therefore, further investigations will be necessary to demonstrate the potential benefit for presurgical selection of patients with various lesion patterns in mesial temporal epilepsies resulting from a unilateral HS. Copyright 2010 AUR. Published by Elsevier Inc. All rights reserved.

High Resolution Global Climate Modeling with GEOS-5: Intense Precipitation, Convection and Tropical Cyclones on Seasonal Time-Scales.

NASA Technical Reports Server (NTRS)

Putnam, WilliamM.

2011-01-01

In 2008 the World Modeling Summit for Climate Prediction concluded that "climate modeling will need-and is ready-to move to fundamentally new high-resolution approaches to capitalize on the seamlessness of the weather-climate continuum." Following from this, experimentation with very high-resolution global climate modeling has gained enhanced priority within many modeling groups and agencies. The NASA Goddard Earth Observing System model (GEOS-5) has been enhanced to provide a capability for the execution at the finest horizontal resolutions POS,SIOle with a global climate model today. Using this high-resolution, non-hydrostatic version of GEOS-5, we have developed a unique capability to explore the intersection of weather and climate within a seamless prediction system. Week-long weather experiments, to mUltiyear climate simulations at global resolutions ranging from 3.5- to 14-km have demonstrated the predictability of extreme events including severe storms along frontal systems, extra-tropical storms, and tropical cyclones. The primary benefits of high resolution global models will likely be in the tropics, with better predictions of the genesis stages of tropical cyclones and of the internal structure of their mature stages. Using satellite data we assess the accuracy of GEOS-5 in representing extreme weather phenomena, and their interaction within the global climate on seasonal time-scales. The impacts of convective parameterization and the frequency of coupling between the moist physics and dynamics are explored in terms of precipitation intensity and the representation of deep convection. We will also describe the seasonal variability of global tropical cyclone activity within a global climate model capable of representing the most intense category 5 hurricanes.

Droplet Image Super Resolution Based on Sparse Representation and Kernel Regression

NASA Astrophysics Data System (ADS)

Zou, Zhenzhen; Luo, Xinghong; Yu, Qiang

2018-02-01

Microgravity and containerless conditions, which are produced via electrostatic levitation combined with a drop tube, are important when studying the intrinsic properties of new metastable materials. Generally, temperature and image sensors can be used to measure the changes of sample temperature, morphology and volume. Then, the specific heat, surface tension, viscosity changes and sample density can be obtained. Considering that the falling speed of the material sample droplet is approximately 31.3 m/s when it reaches the bottom of a 50-meter-high drop tube, a high-speed camera with a collection rate of up to 106 frames/s is required to image the falling droplet. However, at the high-speed mode, very few pixels, approximately 48-120, will be obtained in each exposure time, which results in low image quality. Super-resolution image reconstruction is an algorithm that provides finer details than the sampling grid of a given imaging device by increasing the number of pixels per unit area in the image. In this work, we demonstrate the application of single image-resolution reconstruction in the microgravity and electrostatic levitation for the first time. Here, using the image super-resolution method based on sparse representation, a low-resolution droplet image can be reconstructed. Employed Yang's related dictionary model, high- and low-resolution image patches were combined with dictionary training, and high- and low-resolution-related dictionaries were obtained. The online double-sparse dictionary training algorithm was used in the study of related dictionaries and overcome the shortcomings of the traditional training algorithm with small image patch. During the stage of image reconstruction, the algorithm of kernel regression is added, which effectively overcomes the shortcomings of the Yang image's edge blurs.

Droplet Image Super Resolution Based on Sparse Representation and Kernel Regression

NASA Astrophysics Data System (ADS)

Zou, Zhenzhen; Luo, Xinghong; Yu, Qiang

2018-05-01

Microgravity and containerless conditions, which are produced via electrostatic levitation combined with a drop tube, are important when studying the intrinsic properties of new metastable materials. Generally, temperature and image sensors can be used to measure the changes of sample temperature, morphology and volume. Then, the specific heat, surface tension, viscosity changes and sample density can be obtained. Considering that the falling speed of the material sample droplet is approximately 31.3 m/s when it reaches the bottom of a 50-meter-high drop tube, a high-speed camera with a collection rate of up to 106 frames/s is required to image the falling droplet. However, at the high-speed mode, very few pixels, approximately 48-120, will be obtained in each exposure time, which results in low image quality. Super-resolution image reconstruction is an algorithm that provides finer details than the sampling grid of a given imaging device by increasing the number of pixels per unit area in the image. In this work, we demonstrate the application of single image-resolution reconstruction in the microgravity and electrostatic levitation for the first time. Here, using the image super-resolution method based on sparse representation, a low-resolution droplet image can be reconstructed. Employed Yang's related dictionary model, high- and low-resolution image patches were combined with dictionary training, and high- and low-resolution-related dictionaries were obtained. The online double-sparse dictionary training algorithm was used in the study of related dictionaries and overcome the shortcomings of the traditional training algorithm with small image patch. During the stage of image reconstruction, the algorithm of kernel regression is added, which effectively overcomes the shortcomings of the Yang image's edge blurs.

Megahertz-resolution programmable microwave shaper.

PubMed

Li, Jilong; Dai, Yitang; Yin, Feifei; Li, Wei; Li, Ming; Chen, Hongwei; Xu, Kun

2018-04-15

A novel microwave shaper is proposed and demonstrated, of which the microwave spectral transfer function could be fully programmable with high resolution. We achieve this by bandwidth-compressed mapping a programmable optical wave-shaper, which has a lower frequency resolution of tens of gigahertz, to a microwave one with resolution of tens of megahertz. This is based on a novel technology of "bandwidth scaling," which employs bandwidth-stretched electronic-to-optical conversion and bandwidth-compressed optical-to-electronic conversion. We demonstrate the high resolution and full reconfigurability experimentally. Furthermore, we show the group delay variation could be greatly enlarged after mapping; this is then verified by the experiment with an enlargement of 194 times. The resolution improvement and group delay magnification significantly distinguish our proposal from previous optics-to-microwave spectrum mapping.

Paleoecology and high-resolution paleohydrology of a kettle peatland in upper Michigan

NASA Astrophysics Data System (ADS)

Booth, Robert K.; Jackson, Stephen T.; Gray, Catherine E. D.

2004-01-01

We investigated the developmental and hydrological history of a Sphagnum-dominated, kettle peatland in Upper Michigan using testate amoebae, plant macrofossils, and pollen. Our primary objective was to determine if the paleohydrological record of the peatland represents a record of past climate variability at subcentennial to millennial time scales. To assess the role of millennial-scale climate variability on peatland paleohydrology, we compared the timing of peatland and upland vegetation changes. To investigate the role of higher-frequency climate variability on peatland paleohydrology, we used testate amoebae to reconstruct a high-resolution, hydrologic history of the peatland for the past 5100 years, and compared this record to other regional records of paleoclimate and vegetation. Comparisons revealed coherent patterns of hydrological, vegetational, and climatic changes, suggesting that peatland paleohydrology responded to climate variability at millennial to sub-centennial time scales. Although ombrotrophic peatlands have been the focus of most high-resolution peatland paleoclimate research, paleohydrological records from Sphagnum-dominated, closed-basin peatlands record high-frequency and low-magnitude climatic changes and thus represent a significant source of unexplored paleoclimate data.

Fast front-end electronics for semiconductor tracking detectors: Trends and perspectives

NASA Astrophysics Data System (ADS)

Rivetti, Angelo

2014-11-01

In the past few years, extensive research efforts pursued by both the industry and the academia have lead to major improvements in the performance of Analog to Digital Converters (ADCs) and Time to Digital Converters (TDCs). ADCs achieving 8-10 bit resolution, 50-100 MHz conversion frequency and less than 1 mW power consumption are the today's standard, while TDCs have reached sub-picosecond time resolution. These results have been made possible by architectural upgrades combined with the use of ultra deep submicron CMOS technologies with minimum feature size of 130 nm or smaller. Front-end ASICs in which a prompt digitization is followed by signal conditioning in the digital domain can now be envisaged also within the tight power budget typically available in high density tracking systems. Furthermore, tracking detectors embedding high resolution timing capabilities are gaining interest. In the paper, ADC's and TDC's developments which are of particular relevance for the design front-end electronics for semiconductor trackers are discussed along with the benefits and challenges of exploiting such high performance building blocks in implementing the next generation of ASICs for high granularity particle detectors.

A High-Resolution Capability for Large-Eddy Simulation of Jet Flows

NASA Technical Reports Server (NTRS)

DeBonis, James R.

2011-01-01

A large-eddy simulation (LES) code that utilizes high-resolution numerical schemes is described and applied to a compressible jet flow. The code is written in a general manner such that the accuracy/resolution of the simulation can be selected by the user. Time discretization is performed using a family of low-dispersion Runge-Kutta schemes, selectable from first- to fourth-order. Spatial discretization is performed using central differencing schemes. Both standard schemes, second- to twelfth-order (3 to 13 point stencils) and Dispersion Relation Preserving schemes from 7 to 13 point stencils are available. The code is written in Fortran 90 and uses hybrid MPI/OpenMP parallelization. The code is applied to the simulation of a Mach 0.9 jet flow. Four-stage third-order Runge-Kutta time stepping and the 13 point DRP spatial discretization scheme of Bogey and Bailly are used. The high resolution numerics used allows for the use of relatively sparse grids. Three levels of grid resolution are examined, 3.5, 6.5, and 9.2 million points. Mean flow, first-order turbulent statistics and turbulent spectra are reported. Good agreement with experimental data for mean flow and first-order turbulent statistics is shown.

High-resolution, large dynamic range fiber-optic thermometer with cascaded Fabry-Perot cavities.

PubMed

Liu, Guigen; Sheng, Qiwen; Hou, Weilin; Han, Ming

2016-11-01

The paradox between a large dynamic range and a high resolution commonly exists in nearly all kinds of sensors. Here, we propose a fiber-optic thermometer based on dual Fabry-Perot interferometers (FPIs) made from the same material (silicon), but with different cavity lengths, which enables unambiguous recognition of the dense fringes associated with the thick FPI over the free-spectral range determined by the thin FPI. Therefore, the sensor combines the large dynamic range of the thin FPI and the high resolution of the thick FPI. To verify this new concept, a sensor with one 200 μm thick silicon FPI cascaded by another 10 μm thick silicon FPI was fabricated. A temperature range of -50°C to 130°C and a resolution of 6.8×10^-3°C were demonstrated using a simple average wavelength tracking demodulation. Compared to a sensor with only the thick silicon FPI, the dynamic range of the hybrid sensor was more than 10 times larger. Compared to a sensor with only the thin silicon FPI, the resolution of the hybrid sensor was more than 18 times higher.

3D near-infrared imaging based on a single-photon avalanche diode array sensor

NASA Astrophysics Data System (ADS)

Mata Pavia, Juan; Charbon, Edoardo; Wolf, Martin

2011-07-01

An imager for optical tomography was designed based on a detector with 128×128 single-photon pixels that included a bank of 32 time-to-digital converters. Due to the high spatial resolution and the possibility of performing time resolved measurements, a new contact-less setup has been conceived in which scanning of the object is not necessary. This enables one to perform high-resolution optical tomography with much higher acquisition rate, which is fundamental in clinical applications. The setup has a resolution of 97ps and operates with a laser source with an average power of 3mW. This new imaging system generated a high amount of data that could not be processed by established methods, therefore new concepts and algorithms were developed to take full advantage of it. Images were generated using a new reconstruction algorithm that combined general inverse problem methods with Fourier transforms in order to reduce the complexity of the problem. Simulations show that the potential resolution of the new setup is in the order of millimeters. Experiments have been performed to confirm this potential. Images derived from the measurements demonstrate that we have already reached a resolution of 5mm.

High Spectral Resolution Lidar for atmospheric temperature profiling.

NASA Astrophysics Data System (ADS)

Razenkov, I.; Eloranta, E. W.

2017-12-01

The High Spectral Resolution Lidar (HSRL) designed at the University of Wisconsin-Madison is equipped with two iodine absorption filters with different line widths (1.8 GHz and 2.85 GHz). The filters are implemented to discriminate between Mie and Rayleigh backscattering and to resolve temperature sensitive changes in Rayleigh spectrum for atmospheric temperature profile measurements. This measurement capability makes the instrument intrinsically and absolutely calibrated. HSRL has a shared transmitter-receiver telescope and operates in the eye-safe mode with the product of laser average power and telescope aperture less than 0.025 𝑊𝑚2 at 532 nm. With this low-power prototype instrument we have achieved temperature profile measurements extending above tropopause with a time resolution of several hours. Further instrument optimizations will reduce systematic measurement errors and will improve a signal-to-noise ratio providing temperature data comparable to a standard radiosonde with higher time resolution.

Hypernuclear Spectroscopy with Electron Beam at JLab Hall C

NASA Astrophysics Data System (ADS)

Fujii, Y.; Chiba, A.; Doi, D.; Gogami, T.; Hashimoto, O.; Kanda, H.; Kaneta, M.; Kawama, D.; Maeda, K.; Maruta, T.; Matsumura, A.; Nagao, S.; Nakamura, S. N.; Shichijo, A.; Tamura, H.; Taniya, N.; Yamamoto, T.; Yokota, K.; Kato, S.; Sato, Y.; Takahashi, T.; Noumi, H.; Motoba, T.; Hiyama, E.; Albayrak, I.; Ates, O.; Chen, C.; Christy, M.; Keppel, C.; Kohl, M.; Li, Y.; Liyanage, A.; Tang, L.; Walton, T.; Ye, Z.; Yuan, L.; Zhu, L.; Baturin, P.; Boeglin, W.; Dhamija, S.; Markowitz, P.; Raue, B.; Reinhold, J.; Hungerford, Ed. V.; Ent, R.; Fenker, H.; Gaskell, D.; Horn, T.; Jones, M.; Smith, G.; Vulcan, W.; Wood, S. A.; Johnston, C.; Simicevic, N.; Wells, S.; Samanta, C.; Hu, B.; Shen, J.; Wang, W.; Zhang, X.; Zhang, Y.; Feng, J.; Fu, Y.; Zhou, J.; Zhou, S.; Jiang, Y.; Lu, H.; Yan, X.; Ye, Y.; Gan, L.; Ahmidouch, A.; Danagoulian, S.; Gasparian, A.; Elaasar, M.; Wesselmann, F. R.; Asaturyan, A.; Margaryan, A.; Mkrtchyan, A.; Mkrtchyan, H.; Tadevosyan, V.; Androic, D.; Furic, M.; Petkovic, T.; Seva, T.; Niculescu, G.; Niculescu, I.; López, V. M. Rodríguez; Cisbani, E.; Cusanno, F.; Garibaldi, F.; Uuciuoli, G. M.; de Leo, R.; Maronne, S.

2010-10-01

Hypernuclear spectroscopy with electron beam at JLab Hall C has been studied since 2000. The first experiment, JLab E89-009, demonstrated the possibility of the (e,e'K+) reaction for hypernuclear spectroscopy by achieving an energy resolution of better than 1 MeV (FWHM). The second experiment, JLab E01-011 employed a newly constructed high resolution kaon spectrometer and introduced a vertically tilted electron arm setup to avoid electrons from bremsstrahlung and Moeller scattering. The setup allowed us to have 10 times yield rate and 4 times better signal to accidental ratio with expected energy resolution of 400 keV (FWHM). The third experiment, JLab E05-11B will be performed in 2009 with employing newly constructed high resolution electron spectrometer and a new charge-separation magnet. With the fully customized third generation experimental setup, we can study a variety of targets up to medium-heavy ones such as 52Cr.

Hypernuclear Spectroscopy with Electron Beam at JLab Hall C

NASA Astrophysics Data System (ADS)

Fujii, Y.; Chiba, A.; Doi, D.; Gogami, T.; Hashimoto, O.; Kanda, H.; Kaneta, M.; Kawama, D.; Maeda, K.; Maruta, T.; Matsumura, A.; Nagao, S.; Nakamura, S. N.; Shichijo, A.; Tamura, H.; Taniya, N.; Yamamoto, T.; Yokota, K.; Kato, S.; Sato, Y.; Takahashi, T.; Noumi, H.; Motoba, T.; Hiyama, E.; Albayrak, I.; Ates, O.; Chen, C.; Christy, M.; Keppel, C.; Kohl, M.; Li, Y.; Liyanage, A.; Tang, L.; Walton, T.; Ye, Z.; Yuan, L.; Zhu, L.; Baturin, P.; Boeglin, W.; Dhamija, S.; Markowitz, P.; Raue, B.; Reinhold, J.; Hungerford, Ed. V.; Ent, R.; Fenker, H.; Gaskell, D.; Horn, T.; Jones, M.; Smith, G.; Vulcan, W.; Wood, S. A.; Johnston, C.; Simicevic, N.; Wells, S.; Samanta, C.; Hu, B.; Shen, J.; Wang, W.; Zhang, X.; Zhang, Y.; Feng, J.; Fu, Y.; Zhou, J.; Zhou, S.; Jiang, Y.; Lu, H.; Yan, X.; Ye, Y.; Gan, L.; Ahmidouch, A.; Danagoulian, S.; Gasparian, A.; Elaasar, M.; Wesselmann, F. R.; Asaturyan, A.; Margaryan, A.; Mkrtchyan, A.; Mkrtchyan, H.; Tadevosyan, V.; Androic, D.; Furic, M.; Petkovic, T.; Seva, T.; Niculescu, G.; Niculescu, I.; Rodríguez López, V. M.; Cisbani, E.; Cusanno, F.; Garibaldi, F.; Uuciuoli, G. M.; de Leo, R.; Maronne, S.

Hypernuclear spectroscopy with electron beam at JLab Hall C has been studied since 2000. The first experiment, JLab E89-009, demonstrated the possibility of the (e, e‧ K+) reaction for hypernuclear spectroscopy by achieving an energy resolution of better than 1 MeV (FWHM). The second experiment, JLab E01-011 employed a newly constructed high resolution kaon spectrometer and introduced a vertically tilted electron arm setup to avoid electrons from bremsstrahlung and Moeller scattering. The setup allowed us to have 10 times yield rate and 4 times better signal to accidental ratio with expected energy resolution of 400 keV (FWHM). The third experiment, JLab E05-115 will be performed in 2009 with employing newly constructed high resolution electron spectrometer and a new charge-separation magnet. With the fully customized third generation experimental setup, we can study a variety of targets up to medium-heavy ones such as 52Cr.

Proxy-to-proxy calibration: Increasing the temporal resolution of quantitative climate reconstructions

PubMed Central

von Gunten, Lucien; D'Andrea, William J.; Bradley, Raymond S.; Huang, Yongsong

2012-01-01

High-resolution paleoclimate reconstructions are often restricted by the difficulties of sampling geologic archives in great detail and the analytical costs of processing large numbers of samples. Using sediments from Lake Braya Sø, Greenland, we introduce a new method that provides a quantitative high-resolution paleoclimate record by combining measurements of the alkenone unsaturation index () with non-destructive scanning reflectance spectroscopic measurements in the visible range (VIS-RS). The proxy-to-proxy (PTP) method exploits two distinct calibrations: the in situ calibration of to lake water temperature and the calibration of scanning VIS-RS data to down core data. Using this approach, we produced a quantitative temperature record that is longer and has 5 times higher sampling resolution than the original time series, thereby allowing detection of temperature variability in frequency bands characteristic of the AMO over the past 7,000 years. PMID:22934132

Mapping land cover change over continental Africa using Landsat and Google Earth Engine cloud computing.

PubMed

Midekisa, Alemayehu; Holl, Felix; Savory, David J; Andrade-Pacheco, Ricardo; Gething, Peter W; Bennett, Adam; Sturrock, Hugh J W

2017-01-01

Quantifying and monitoring the spatial and temporal dynamics of the global land cover is critical for better understanding many of the Earth's land surface processes. However, the lack of regularly updated, continental-scale, and high spatial resolution (30 m) land cover data limit our ability to better understand the spatial extent and the temporal dynamics of land surface changes. Despite the free availability of high spatial resolution Landsat satellite data, continental-scale land cover mapping using high resolution Landsat satellite data was not feasible until now due to the need for high-performance computing to store, process, and analyze this large volume of high resolution satellite data. In this study, we present an approach to quantify continental land cover and impervious surface changes over a long period of time (15 years) using high resolution Landsat satellite observations and Google Earth Engine cloud computing platform. The approach applied here to overcome the computational challenges of handling big earth observation data by using cloud computing can help scientists and practitioners who lack high-performance computational resources.

Mapping land cover change over continental Africa using Landsat and Google Earth Engine cloud computing

PubMed Central

Holl, Felix; Savory, David J.; Andrade-Pacheco, Ricardo; Gething, Peter W.; Bennett, Adam; Sturrock, Hugh J. W.

2017-01-01

Quantifying and monitoring the spatial and temporal dynamics of the global land cover is critical for better understanding many of the Earth’s land surface processes. However, the lack of regularly updated, continental-scale, and high spatial resolution (30 m) land cover data limit our ability to better understand the spatial extent and the temporal dynamics of land surface changes. Despite the free availability of high spatial resolution Landsat satellite data, continental-scale land cover mapping using high resolution Landsat satellite data was not feasible until now due to the need for high-performance computing to store, process, and analyze this large volume of high resolution satellite data. In this study, we present an approach to quantify continental land cover and impervious surface changes over a long period of time (15 years) using high resolution Landsat satellite observations and Google Earth Engine cloud computing platform. The approach applied here to overcome the computational challenges of handling big earth observation data by using cloud computing can help scientists and practitioners who lack high-performance computational resources. PMID:28953943

High-resolution low-dose scanning transmission electron microscopy.

PubMed

Buban, James P; Ramasse, Quentin; Gipson, Bryant; Browning, Nigel D; Stahlberg, Henning

2010-01-01

During the past two decades instrumentation in scanning transmission electron microscopy (STEM) has pushed toward higher intensity electron probes to increase the signal-to-noise ratio of recorded images. While this is suitable for robust specimens, biological specimens require a much reduced electron dose for high-resolution imaging. We describe here protocols for low-dose STEM image recording with a conventional field-emission gun STEM, while maintaining the high-resolution capability of the instrument. Our findings show that a combination of reduced pixel dwell time and reduced gun current can achieve radiation doses comparable to low-dose TEM.

Analysis of high-resolution foreign exchange data of USD-JPY for 13 years

NASA Astrophysics Data System (ADS)

Mizuno, Takayuki; Kurihara, Shoko; Takayasu, Misako; Takayasu, Hideki

2003-06-01

We analyze high-resolution foreign exchange data consisting of 20 million data points of USD-JPY for 13 years to report firm statistical laws in distributions and correlations of exchange rate fluctuations. A conditional probability density analysis clearly shows the existence of trend-following movements at time scale of 8-ticks, about 1 min.

Super-Resolution Image Reconstruction by Nonlocal Means Applied to High-Angle Annular Darkfield Scanning Transmission Electron Microscopy (HAADF-STEM)

DTIC Science & Technology

2009-10-06

When talking about superresolution we always mean to recover the level of resolution set by the microscope, but by using a time series of low...on low resolution possibly very noisy data, is not feasible. Thus, standard superresolution concepts as described above that are based on registration

Sirenum Fossae Trough

NASA Technical Reports Server (NTRS)

2000-01-01

[figure removed for brevity, see original site]

The Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) orbits the red planet twelve times each day. The number of pictures that MOC can take varies from orbit to orbit, depending upon whether the data are being stored in MGS's onboard tape recorder for playback at a later time, or whether the data are being sent directly back to Earth via a real-time radio link. More data can be acquired during orbits with real-time downlink.

During real-time orbits, the MOC team often will take a few random or semi-random pictures in between the carefully-selected, hand-targeted images. On rare occasions, one of these random pictures will surprise the MOC team. The picture shown here is an excellent example, because the high resolution view (top) is centered so nicely on a trough and an adjacent, shallow crater that it is as if someone very carefully selected the target for MOC. The high-resolution view covers an area only 1.1 km (0.7 mi) wide by 2.3 km (1.4 mi) long. Hitting a target such as this with such a small image is very difficult to do, on purpose, because there are small uncertainties in the predicted orbit, the maps used to select targets, and the minor adjustments of spacecraft pointing at any given moment. Nevertheless, a very impressive image was received.

The high resolution view crosses one of the troughs of the Sirenum Fossae near 31.2oS, 152.3oW. The context image (above) was acquired at the same time as the high resolution view on July 23, 2000. The small white box shows the location of the high resolution picture. The lines running diagonally across the context image from upper right toward lower left are the Sirenum Fossae troughs, formed by faults that are radial to the volcanic region of Tharsis. Both pictures are illuminated from the upper left. The scene shows part of the martian southern hemisphere nearly autumn.

High frequency resolution terahertz time-domain spectroscopy

NASA Astrophysics Data System (ADS)

Sangala, Bagvanth Reddy

2013-12-01

A new method for the high frequency resolution terahertz time-domain spectroscopy is developed based on the characteristic matrix method. This method is useful for studying planar samples or stack of planar samples. The terahertz radiation was generated by optical rectification in a ZnTe crystal and detected by another ZnTe crystal via electro-optic sampling method. In this new characteristic matrix based method, the spectra of the sample and reference waveforms will be modeled by using characteristic matrices. We applied this new method to measure the optical constants of air. The terahertz transmission through the layered systems air-Teflon-air-Quartz-air and Nitrogen gas-Teflon-Nitrogen gas-Quartz-Nitrogen gas was modeled by the characteristic matrix method. A transmission coefficient is derived from these models which was optimized to fit the experimental transmission coefficient to extract the optical constants of air. The optimization of an error function involving the experimental complex transmission coefficient and the theoretical transmission coefficient was performed using patternsearch algorithm of MATLAB. Since this method takes account of the echo waveforms due to reflections in the layered samples, this method allows analysis of longer time-domain waveforms giving rise to very high frequency resolution in the frequency-domain. We have presented the high frequency resolution terahertz time-domain spectroscopy of air and compared the results with the literature values. We have also fitted the complex susceptibility of air to the Lorentzian and Gaussian functions to extract the linewidths.

Multi-GPU Accelerated Admittance Method for High-Resolution Human Exposure Evaluation.

PubMed

Xiong, Zubiao; Feng, Shi; Kautz, Richard; Chandra, Sandeep; Altunyurt, Nevin; Chen, Ji

2015-12-01

A multi-graphics processing unit (GPU) accelerated admittance method solver is presented for solving the induced electric field in high-resolution anatomical models of human body when exposed to external low-frequency magnetic fields. In the solver, the anatomical model is discretized as a three-dimensional network of admittances. The conjugate orthogonal conjugate gradient (COCG) iterative algorithm is employed to take advantage of the symmetric property of the complex-valued linear system of equations. Compared against the widely used biconjugate gradient stabilized method, the COCG algorithm can reduce the solving time by 3.5 times and reduce the storage requirement by about 40%. The iterative algorithm is then accelerated further by using multiple NVIDIA GPUs. The computations and data transfers between GPUs are overlapped in time by using asynchronous concurrent execution design. The communication overhead is well hidden so that the acceleration is nearly linear with the number of GPU cards. Numerical examples show that our GPU implementation running on four NVIDIA Tesla K20c cards can reach 90 times faster than the CPU implementation running on eight CPU cores (two Intel Xeon E5-2603 processors). The implemented solver is able to solve large dimensional problems efficiently. A whole adult body discretized in 1-mm resolution can be solved in just several minutes. The high efficiency achieved makes it practical to investigate human exposure involving a large number of cases with a high resolution that meets the requirements of international dosimetry guidelines.

Fiber optic cable-based high-resolution, long-distance VGA extenders

NASA Astrophysics Data System (ADS)

Rhee, Jin-Geun; Lee, Iksoo; Kim, Heejoon; Kim, Sungjoon; Koh, Yeon-Wan; Kim, Hoik; Lim, Jiseok; Kim, Chur; Kim, Jungwon

2013-02-01

Remote transfer of high-resolution video information finds more applications in detached display applications for large facilities such as theaters, sports complex, airports, and security facilities. Active optical cables (AOCs) provide a promising approach for enhancing both the transmittable resolution and distance that standard copper-based cables cannot reach. In addition to the standard digital formats such as HDMI, the high-resolution, long-distance transfer of VGA format signals is important for applications where high-resolution analog video ports should be also supported, such as military/defense applications and high-resolution video camera links. In this presentation we present the development of a compressionless, high-resolution (up to WUXGA, 1920x1200), long-distance (up to 2 km) VGA extenders based on serialized technique. We employed asynchronous serial transmission and clock regeneration techniques, which enables lower cost implementation of VGA extenders by removing the necessity for clock transmission and large memory at the receiver. Two 3.125-Gbps transceivers are used in parallel to meet the required maximum video data rate of 6.25 Gbps. As the data are transmitted asynchronously, 24-bit pixel clock time stamp is employed to regenerate video pixel clock accurately at the receiver side. In parallel to the video information, stereo audio and RS-232 control signals are transmitted as well.

Towards high-resolution 4D flow MRI in the human aorta using kt-GRAPPA and B1+ shimming at 7T.

PubMed

Schmitter, Sebastian; Schnell, Susanne; Uğurbil, Kâmil; Markl, Michael; Van de Moortele, Pierre-François

2016-08-01

To evaluate the feasibility of aortic 4D flow magnetic resonance imaging (MRI) at 7T with improved spatial resolution using kt-GRAPPA acceleration while restricting acquisition time and to address radiofrequency (RF) excitation heterogeneities with B1+ shimming. 4D flow MRI data were obtained in the aorta of eight subjects using a 16-channel transmit/receive coil array at 7T. Flow quantification and acquisition time were compared for a kt-GRAPPA accelerated (R = 5) and a standard GRAPPA (R = 2) accelerated protocol. The impact of different dynamic B1+ shimming strategies on flow quantification was investigated. Two kt-GRAPPA accelerated protocols with 1.2 × 1.2 × 1.2 mm(3) and 1.8 × 1.8 × 2.4 mm(3) spatial resolution were compared. Using kt-GRAPPA, we achieved a 4.3-fold reduction in net acquisition time resulting in scan times of about 10 minutes. No significant effect on flow quantification was observed compared to standard GRAPPA with R = 2. Optimizing the B1+ fields for the aorta impacted significantly (P <  0.05) the flow quantification while specific B1+ settings were required for respiration navigators. The high-resolution protocol yielded similar flow quantification, but allowed the depiction of branching vessels. 7T in combination with B1+ shimming allows for high-resolution 4D flow MRI acquisitions in the human aorta, while kt-GRAPPA limits total scan times without affecting flow quantification. J. Magn. Reson. Imaging 2016;44:486-499. © 2016 Wiley Periodicals, Inc.

High-resolution dynamic pressure sensor array based on piezo-phototronic effect tuned photoluminescence imaging.

PubMed

Peng, Mingzeng; Li, Zhou; Liu, Caihong; Zheng, Qiang; Shi, Xieqing; Song, Ming; Zhang, Yang; Du, Shiyu; Zhai, Junyi; Wang, Zhong Lin

2015-03-24

A high-resolution dynamic tactile/pressure display is indispensable to the comprehensive perception of force/mechanical stimulations such as electronic skin, biomechanical imaging/analysis, or personalized signatures. Here, we present a dynamic pressure sensor array based on pressure/strain tuned photoluminescence imaging without the need for electricity. Each sensor is a nanopillar that consists of InGaN/GaN multiple quantum wells. Its photoluminescence intensity can be modulated dramatically and linearly by small strain (0-0.15%) owing to the piezo-phototronic effect. The sensor array has a high pixel density of 6350 dpi and exceptional small standard deviation of photoluminescence. High-quality tactile/pressure sensing distribution can be real-time recorded by parallel photoluminescence imaging without any cross-talk. The sensor array can be inexpensively fabricated over large areas by semiconductor product lines. The proposed dynamic all-optical pressure imaging with excellent resolution, high sensitivity, good uniformity, and ultrafast response time offers a suitable way for smart sensing, micro/nano-opto-electromechanical systems.

TH-EF-BRA-11: Feasibility of Super-Resolution Time-Resolved 4DMRI for Multi-Breath Volumetric Motion Simulation in Radiotherapy Planning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, G; Zakian, K; Deasy, J

Purpose: To develop a novel super-resolution time-resolved 4DMRI technique to evaluate multi-breath, irregular and complex organ motion without respiratory surrogate for radiotherapy planning. Methods: The super-resolution time-resolved (TR) 4DMRI approach combines a series of low-resolution 3D cine MRI images acquired during free breathing (FB) with a high-resolution breath-hold (BH) 3DMRI via deformable image registration (DIR). Five volunteers participated in the study under an IRB-approved protocol. The 3D cine images with voxel size of 5×5×5 mm{sup 3} at two volumes per second (2Hz) were acquired coronally using a T1 fast field echo sequence, half-scan (0.8) acceleration, and SENSE (3) parallel imaging.more » Phase-encoding was set in the lateral direction to minimize motion artifacts. The BH image with voxel size of 2×2×2 mm{sup 3} was acquired using the same sequence within 10 seconds. A demons-based DIR program was employed to produce super-resolution 2Hz 4DMRI. Registration quality was visually assessed using difference images between TR 4DMRI and 3D cine and quantitatively assessed using average voxel correlation. The fidelity of the 3D cine images was assessed using a gel phantom and a 1D motion platform by comparing mobile and static images. Results: Owing to voxel intensity similarity using the same MRI scanning sequence, accurate DIR between FB and BH images is achieved. The voxel correlations between 3D cine and TR 4DMRI are greater than 0.92 in all cases and the difference images illustrate minimal residual error with little systematic patterns. The 3D cine images of the mobile gel phantom preserve object geometry with minimal scanning artifacts. Conclusion: The super-resolution time-resolved 4DMRI technique has been achieved via DIR, providing a potential solution for multi-breath motion assessment. Accurate DIR mapping has been achieved to map high-resolution BH images to low-resolution FB images, producing 2Hz volumetric high-resolution 4DMRI. Further validation and improvement are still required prior to clinical applications. This study is in part supported by the NIH (U54CA137788/U54CA132378).« less

Note: Large active area solid state photon counter with 20 ps timing resolution and 60 fs detection delay stability

NASA Astrophysics Data System (ADS)

Prochazka, Ivan; Kodet, Jan; Eckl, Johann; Blazej, Josef

2017-10-01

We are reporting on the design, construction, and performance of a photon counting detector system, which is based on single photon avalanche diode detector technology. This photon counting device has been optimized for very high timing resolution and stability of its detection delay. The foreseen application of this detector is laser ranging of space objects, laser time transfer ground to space and fundamental metrology. The single photon avalanche diode structure, manufactured on silicon using K14 technology, is used as a sensor. The active area of the sensor is circular with 200 μm diameter. Its photon detection probability exceeds 40% in the wavelength range spanning from 500 to 800 nm. The sensor is operated in active quenching and gating mode. A new control circuit was optimized to maintain high timing resolution and detection delay stability. In connection to this circuit, timing resolution of the detector is reaching 20 ps FWHM. In addition, the temperature change of the detection delay is as low as 70 fs/K. As a result, the detection delay stability of the device is exceptional: expressed in the form of time deviation, detection delay stability of better than 60 fs has been achieved. Considering the large active area aperture of the detector, this is, to our knowledge, the best timing performance reported for a solid state photon counting detector so far.

High-Resolution NMR Reveals Secondary Structure and Folding of Amino Acid Transporter from Outer Chloroplast Membrane

PubMed Central

Zook, James D.; Molugu, Trivikram R.; Jacobsen, Neil E.; Lin, Guangxin; Soll, Jürgen; Cherry, Brian R.; Brown, Michael F.; Fromme, Petra

2013-01-01

Solving high-resolution structures for membrane proteins continues to be a daunting challenge in the structural biology community. In this study we report our high-resolution NMR results for a transmembrane protein, outer envelope protein of molar mass 16 kDa (OEP16), an amino acid transporter from the outer membrane of chloroplasts. Three-dimensional, high-resolution NMR experiments on the 13C, 15N, 2H-triply-labeled protein were used to assign protein backbone resonances and to obtain secondary structure information. The results yield over 95% assignment of N, HN, CO, Cα, and Cβ chemical shifts, which is essential for obtaining a high resolution structure from NMR data. Chemical shift analysis from the assignment data reveals experimental evidence for the first time on the location of the secondary structure elements on a per residue basis. In addition T 1Z and T2 relaxation experiments were performed in order to better understand the protein dynamics. Arginine titration experiments yield an insight into the amino acid residues responsible for protein transporter function. The results provide the necessary basis for high-resolution structural determination of this important plant membrane protein. PMID:24205117

High Resolution Live Cell Raman Imaging Using Subcellular Organelle-Targeting SERS-Sensitive Gold Nanoparticles with Highly Narrow Intra-Nanogap

PubMed Central

Kang, Jeon Woong; So, Peter T. C.; Dasari, Ramachandra R.; Lim, Dong-Kwon

2015-01-01

We report a method to achieve high speed and high resolution live cell Raman images using small spherical gold nanoparticles with highly narrow intra-nanogap structures responding to NIR excitation (785 nm) and high-speed confocal Raman microscopy. The three different Raman-active molecules placed in the narrow intra-nanogap showed a strong and uniform Raman intensity in solution even under transient exposure time (10 ms) and low input power of incident laser (200 μW), which lead to obtain high-resolution single cell image within 30 s without inducing significant cell damage. The high resolution Raman image showed the distributions of gold nanoparticles for their targeted sites such as cytoplasm, mitochondria, or nucleus. The high speed Raman-based live cell imaging allowed us to monitor rapidly changing cell morphologies during cell death induced by the addition of highly toxic KCN solution to cells. These results strongly suggest that the use of SERS-active nanoparticle can greatly improve the current temporal resolution and image quality of Raman-based cell images enough to obtain the detailed cell dynamics and/or the responses of cells to potential drug molecules. PMID:25646716

A homemade high-resolution orthogonal-injection time-of-flight mass spectrometer with a heated capillary inlet

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guo Changjuan; Huang Zhengxu; Gao Wei

2008-01-15

We describe a homemade high-resolution orthogonal-injection time-of-flight (O-TOF) mass spectrometer combing a heated capillary inlet. The O-TOF uses a heated capillary tube combined with a radio-frequency only quadrupole (rf-only quadrupole) as an interface to help the ion transmission from the atmospheric pressure to the low-pressure regions. The principle, configuration of the O-TOF, and the performance of the instrument are introduced in this paper. With electrospray ion source, the performances of the mass resolution, the sensitivity, the mass range, and the mass accuracy are described. We also include our results obtained by coupling atmospheric pressure matrix-assisted laser deporption ionization with thismore » instrument.« less

Note: Near infrared spectral and transient measurements of PbS quantum dots luminescence.

PubMed

Parfenov, P S; Litvin, A P; Ushakova, E V; Fedorov, A V; Baranov, A V; Berwick, K

2013-11-01

We describe an experimental setup for the characterization of luminescence from nanostructures. The setup is intended for steady-state and time-resolved luminescence measurements in the near-infrared region. The setup allows us to study spectral luminescence properties in the spectral range of 0.8-2.0 μm with high spectral resolution and kinetic luminescence properties between 0.8 and 1.7 μm with a time resolution of 3 ns. The capabilities of the system are illustrated by taking luminescence measurements from PbS quantum dots. We established the size dependencies of the optical properties of the PbS quantum dots over a wide spectral range. Finally, the energy transfer process was studied with a high temporal and spectral resolution.

High-resolution differential mode delay measurement for a multimode optical fiber using a modified optical frequency domain reflectometer.

PubMed

Ahn, T-J; Kim, D

2005-10-03

A novel differential mode delay (DMD) measurement technique for a multimode optical fiber based on optical frequency domain reflectometry (OFDR) has been proposed. We have obtained a high-resolution DMD value of 0.054 ps/m for a commercial multimode optical fiber with length of 50 m by using a modified OFDR in a Mach-Zehnder interferometer structure with a tunable external cavity laser and a Mach-Zehnder interferometer instead of Michelson interferometer. We have also compared the OFDR measurement results with those obtained using a traditional time-domain measurement method. DMD resolution with our proposed OFDR technique is more than an order of magnitude better than a result obtainable with a conventional time-domain method.

Enabling high grayscale resolution displays and accurate response time measurements on conventional computers.

PubMed

Li, Xiangrui; Lu, Zhong-Lin

2012-02-29

Display systems based on conventional computer graphics cards are capable of generating images with 8-bit gray level resolution. However, most experiments in vision research require displays with more than 12 bits of luminance resolution. Several solutions are available. Bit++ (1) and DataPixx (2) use the Digital Visual Interface (DVI) output from graphics cards and high resolution (14 or 16-bit) digital-to-analog converters to drive analog display devices. The VideoSwitcher (3) described here combines analog video signals from the red and blue channels of graphics cards with different weights using a passive resister network (4) and an active circuit to deliver identical video signals to the three channels of color monitors. The method provides an inexpensive way to enable high-resolution monochromatic displays using conventional graphics cards and analog monitors. It can also provide trigger signals that can be used to mark stimulus onsets, making it easy to synchronize visual displays with physiological recordings or response time measurements. Although computer keyboards and mice are frequently used in measuring response times (RT), the accuracy of these measurements is quite low. The RTbox is a specialized hardware and software solution for accurate RT measurements. Connected to the host computer through a USB connection, the driver of the RTbox is compatible with all conventional operating systems. It uses a microprocessor and high-resolution clock to record the identities and timing of button events, which are buffered until the host computer retrieves them. The recorded button events are not affected by potential timing uncertainties or biases associated with data transmission and processing in the host computer. The asynchronous storage greatly simplifies the design of user programs. Several methods are available to synchronize the clocks of the RTbox and the host computer. The RTbox can also receive external triggers and be used to measure RT with respect to external events. Both VideoSwitcher and RTbox are available for users to purchase. The relevant information and many demonstration programs can be found at http://lobes.usc.edu/.

Gain-guided soliton fiber laser with high-quality rectangle spectrum for ultrafast time-stretch microscopy.

PubMed

Hu, Song; Yao, Jian; Liu, Meng; Luo, Ai-Ping; Luo, Zhi-Chao; Xu, Wen-Cheng

2016-05-16

The ultrafast time-stretch microscopy has been proposed to enhance the temporal resolution of a microscopy system. The optical source is a key component for ultrafast time-stretch microscopy system. Herein, we reported on the gain-guided soliton fiber laser with high-quality rectangle spectrum for ultrafast time-stretch microscopy. By virtue of the excellent characteristics of the gain-guided soliton, the output power and the 3-dB bandwidth of the stable mode-locked soliton could be up to 3 mW and 33.7 nm with a high-quality rectangle shape, respectively. With the proposed robust optical source, the ultrafast time-stretch microscopy with the 49.6 μm resolution and a scan rate of 11 MHz was achieved without the external optical amplification. The obtained results demonstrated that the gain-guided soliton fiber laser could be used as an alternative high-quality optical source for ultrafast time-stretch microscopy and will introduce some applications in fields such as biology, chemical, and optical sensing.

New high resolution Random Telegraph Noise (RTN) characterization method for resistive RAM

NASA Astrophysics Data System (ADS)

Maestro, M.; Diaz, J.; Crespo-Yepes, A.; Gonzalez, M. B.; Martin-Martinez, J.; Rodriguez, R.; Nafria, M.; Campabadal, F.; Aymerich, X.

2016-01-01

Random Telegraph Noise (RTN) is one of the main reliability problems of resistive switching-based memories. To understand the physics behind RTN, a complete and accurate RTN characterization is required. The standard equipment used to analyse RTN has a typical time resolution of ∼2 ms which prevents evaluating fast phenomena. In this work, a new RTN measurement procedure, which increases the measurement time resolution to 2 μs, is proposed. The experimental set-up, together with the recently proposed Weighted Time Lag (W-LT) method for the analysis of RTN signals, allows obtaining a more detailed and precise information about the RTN phenomenon.

High-resolution distributed temperature sensing with the multiphoton-timing technique

NASA Astrophysics Data System (ADS)

Höbel, M.; Ricka, J.; Wüthrich, M.; Binkert, Th.

1995-06-01

We report on a multiphoton-timing distributed temperature sensor (DTS) based on the concept of distributed anti-Stokes Raman thermometry. The sensor combines the advantage of very high spatial resolution (40 cm) with moderate measurement times. In 5 min it is possible to determine the temperature of as many as 4000 points along an optical fiber with an accuracy Delta T less than 2 deg C. The new feature of the DTS system is the combination of a fast single-photon avalanche diode with specially designed real-time signal-processing electronics. We discuss various parameters that affect the operation of analog and photon-timing DTS systems. Particular emphasis is put on the consequences of the nonideal behavior of sensor components and the corresponding correction procedures.

Super-resolution Time-Lapse Seismic Waveform Inversion

NASA Astrophysics Data System (ADS)

Ovcharenko, O.; Kazei, V.; Peter, D. B.; Alkhalifah, T.

2017-12-01

Time-lapse seismic waveform inversion is a technique, which allows tracking changes in the reservoirs over time. Such monitoring is relatively computationally extensive and therefore it is barely feasible to perform it on-the-fly. Most of the expenses are related to numerous FWI iterations at high temporal frequencies, which is inevitable since the low-frequency components can not resolve fine scale features of a velocity model. Inverted velocity changes are also blurred when there is noise in the data, so the problem of low-resolution images is widely known. One of the problems intensively tackled by computer vision research community is the recovering of high-resolution images having their low-resolution versions. Usage of artificial neural networks to reach super-resolution from a single downsampled image is one of the leading solutions for this problem. Each pixel of the upscaled image is affected by all the pixels of its low-resolution version, which enables the workflow to recover features that are likely to occur in the corresponding environment. In the present work, we adopt machine learning image enhancement technique to improve the resolution of time-lapse full-waveform inversion. We first invert the baseline model with conventional FWI. Then we run a few iterations of FWI on a set of the monitoring data to find desired model changes. These changes are blurred and we enhance their resolution by using a deep neural network. The network is trained to map low-resolution model updates predicted by FWI into the real perturbations of the baseline model. For supervised training of the network we generate a set of random perturbations in the baseline model and perform FWI on the noisy data from the perturbed models. We test the approach on a realistic perturbation of Marmousi II model and demonstrate that it outperforms conventional convolution-based deblurring techniques.

Quantitative 3D high resolution transmission ultrasound tomography: creating clinically relevant images (Conference Presentation)

NASA Astrophysics Data System (ADS)

Wiskin, James; Klock, John; Iuanow, Elaine; Borup, Dave T.; Terry, Robin; Malik, Bilal H.; Lenox, Mark

2017-03-01

There has been a great deal of research into ultrasound tomography for breast imaging over the past 35 years. Few successful attempts have been made to reconstruct high-resolution images using transmission ultrasound. To this end, advances have been made in 2D and 3D algorithms that utilize either time of arrival or full wave data to reconstruct images with high spatial and contrast resolution suitable for clinical interpretation. The highest resolution and quantitative accuracy result from inverse scattering applied to full wave data in 3D. However, this has been prohibitively computationally expensive, meaning that full inverse scattering ultrasound tomography has not been considered clinically viable. Here we show the results of applying a nonlinear inverse scattering algorithm to 3D data in a clinically useful time frame. This method yields Quantitative Transmission (QT) ultrasound images with high spatial and contrast resolution. We reconstruct sound speeds for various 2D and 3D phantoms and verify these values with independent measurements. The data are fully 3D as is the reconstruction algorithm, with no 2D approximations. We show that 2D reconstruction algorithms can introduce artifacts into the QT breast image which are avoided by using a full 3D algorithm and data. We show high resolution gross and microscopic anatomic correlations comparing cadaveric breast QT images with MRI to establish imaging capability and accuracy. Finally, we show reconstructions of data from volunteers, as well as an objective visual grading analysis to confirm clinical imaging capability and accuracy.

Daily High-Resolution Flood Maps of Africa: 1992-present with Near Real Time Updates

NASA Astrophysics Data System (ADS)

Picton, J.; Galantowicz, J. F.; Root, B.

2016-12-01

The ability to characterize past and current flood extents frequently, accurately, and at high resolution is needed for many applications including risk assessment, wetlands monitoring, and emergency management. However, remote sensing methods have not been capable of meeting all of these requirements simultaneously. Cloud cover too often obscures the surface for visual and infrared sensors and observations from radar sensors are too infrequent to create consistent historical databases or monitor evolving events. Lower-resolution (10-50 km) passive microwave sensors, such as SSM/I, AMSR-E, and AMSR2, are sensitive to water cover, acquire useful data during clear and cloudy conditions, have revisit periods of up to twice daily, and provide a continuous record of data from 1992 to the present. What they lack most is the resolution needed to map flood extent. We will present results from a flood mapping system capable of producing high-resolution (90-m) flood extent depictions from lower resolution microwave data. The system uses the strong sensitivity of microwave data to surface water coverage combined with land surface and atmospheric data to derive daily flooded fraction estimates on a sensor-footprint basis. The system downscales flooded fraction to make high-resolution Boolean flood extent depictions that are spatially continuous and consistent with the lower resolution data. The downscaling step is based on a relative floodability (RF) index derived from higher-resolution topographic and hydrological data. We process RF to create a flooded fraction threshold map that relates each 90-m grid point to the surrounding terrain at the microwave scale. We have derived daily, 90-m resolution flood maps for Africa covering 1992-present using SSM/I, AMSR-E, and AMSR2 data and we are now producing new daily maps in near real time. The flood maps are being used by the African Risk Capacity (ARC) Agency to underpin an intergovernmental river flood insurance program in Africa. We will present results showing daily flood extents during major events and discuss: validation of the flood maps against MODIS-derived maps; analyses of minimum detectable flood size; aggregate analyses of flood extent over time; flood map use in ARC's insurance model; and results applying the system to the Americas.

Unravelling earth flow dynamics with 3-D time series derived from UAV-SfM models

NASA Astrophysics Data System (ADS)

Clapuyt, François; Vanacker, Veerle; Schlunegger, Fritz; Van Oost, Kristof

2017-12-01

Accurately assessing geo-hazards and quantifying landslide risks in mountainous environments are gaining importance in the context of the ongoing global warming. For an in-depth understanding of slope failure mechanisms, accurate monitoring of the mass movement topography at high spatial and temporal resolutions remains essential. The choice of the acquisition framework for high-resolution topographic reconstructions will mainly result from the trade-off between the spatial resolution needed and the extent of the study area. Recent advances in the development of unmanned aerial vehicle (UAV)-based image acquisition combined with the structure-from-motion (SfM) algorithm for three-dimensional (3-D) reconstruction make the UAV-SfM framework a competitive alternative to other high-resolution topographic techniques. In this study, we aim at gaining in-depth knowledge of the Schimbrig earthflow located in the foothills of the Central Swiss Alps by monitoring ground surface displacements at very high spatial and temporal resolution using the efficiency of the UAV-SfM framework. We produced distinct topographic datasets for three acquisition dates between 2013 and 2015 in order to conduct a comprehensive 3-D analysis of the landslide. Therefore, we computed (1) the sediment budget of the hillslope, and (2) the horizontal and (3) the three-dimensional surface displacements. The multitemporal UAV-SfM based topographic reconstructions allowed us to quantify rates of sediment redistribution and surface movements. Our data show that the Schimbrig earthflow is very active, with mean annual horizontal displacement ranging between 6 and 9 m. Combination and careful interpretation of high-resolution topographic analyses reveal the internal mechanisms of the earthflow and its complex rotational structure. In addition to variation in horizontal surface movements through time, we interestingly showed that the configuration of nested rotational units changes through time. Although there are major changes in the internal structure of the earthflow in the 2013-2015 period, the sediment budget of the drainage basin is nearly in equilibrium. As a consequence, our data show that the time lag between sediment mobilization by landslides and enhanced sediment fluxes in the river network can be considerable.

High-resolution multiphoton microscopy with a low-power continuous wave laser pump.

PubMed

Chen, Xiang-Dong; Li, Shen; Du, Bo; Dong, Yang; Wang, Ze-Hao; Guo, Guang-Can; Sun, Fang-Wen

2018-02-15

Multiphoton microscopy (MPM) has been widely used for three-dimensional biological imaging. Here, based on the photon-induced charge state conversion process, we demonstrated a low-power high-resolution MPM with a nitrogen vacancy (NV) center in diamond. Continuous wave green and orange lasers were used to pump and detect the two-photon charge state conversion, respectively. The power of the laser for multiphoton excitation was 40 μW. Both the axial and lateral resolutions were improved approximately 1.5 times compared with confocal microscopy. The results can be used to improve the resolution of the NV center-based quantum sensing and biological imaging.

High resolution separations of charge variants and disulfide isomers of monoclonal antibodies and antibody drug conjugates using ultra-high voltage capillary electrophoresis with high electric field strength.

PubMed

Henley, W Hampton; He, Yan; Mellors, J Scott; Batz, Nicholas G; Ramsey, J Michael; Jorgenson, James W

2017-11-10

Ultra-high voltage capillary electrophoresis with high electric field strength has been applied to the separation of the charge variants, drug conjugates, and disulfide isomers of monoclonal antibodies. Samples composed of many closely related species are difficult to resolve and quantify using traditional analytical instrumentation. High performance instrumentation can often save considerable time and effort otherwise spent on extensive method development. Ideally, the resolution obtained for a given CE buffer system scales with the square root of the applied voltage. Currently available commercial CE instrumentation is limited to an applied voltage of approximately 30kV and a maximum electric field strength of 1kV/cm due to design limitations. The instrumentation described here is capable of safely applying potentials of at least 120kV with electric field strengths over 2000V/cm, potentially doubling the resolution of the best conventional CE buffer/capillary systems while decreasing analysis time in some applications. Separations of these complex mixtures using this new instrumentation demonstrate the potential of ultra-high voltage CE to identify the presence of previously unresolved components and to reduce analysis time for complex mixtures of antibody variants and drug conjugates. Copyright © 2017 Elsevier B.V. All rights reserved.

Super resolution reconstruction of infrared images based on classified dictionary learning

NASA Astrophysics Data System (ADS)

Liu, Fei; Han, Pingli; Wang, Yi; Li, Xuan; Bai, Lu; Shao, Xiaopeng

2018-05-01

Infrared images always suffer from low-resolution problems resulting from limitations of imaging devices. An economical approach to combat this problem involves reconstructing high-resolution images by reasonable methods without updating devices. Inspired by compressed sensing theory, this study presents and demonstrates a Classified Dictionary Learning method to reconstruct high-resolution infrared images. It classifies features of the samples into several reasonable clusters and trained a dictionary pair for each cluster. The optimal pair of dictionaries is chosen for each image reconstruction and therefore, more satisfactory results is achieved without the increase in computational complexity and time cost. Experiments and results demonstrated that it is a viable method for infrared images reconstruction since it improves image resolution and recovers detailed information of targets.

Basilar artery atherosclerotic plaques in paramedian and lacunar pontine infarctions: a high-resolution MRI study.

PubMed

Klein, Isabelle F; Lavallée, Philippa C; Mazighi, Mikael; Schouman-Claeys, Elisabeth; Labreuche, Julien; Amarenco, Pierre

2010-07-01

Pontine infarction is most often related to basilar artery atherosclerosis when the lesion abuts on the basal surface (paramedian pontine infarction), whereas small medial pontine lesion is usually attributed to small vessel lipohyalinosis. A previous study has found that high-resolution MRI can detect basilar atherosclerotic plaques in up to 70% of patient with paramedian pontine infarction, even in patients with normal angiograms, but none has evaluated the presence of basilar artery plaque by high-resolution MRI in patients with small medial pontine lesion in the medial part of the pons. Consecutive patients with pontine infarction underwent basilar angiography using time-of-flight and contrast-enhanced 3-dimensional MR angiography to assess the presence of basilar artery stenosis and high-resolution MRI to assess the presence of atherosclerotic plaque. Basilar artery angiogram was scored as "normal," "irregular," or "stenosed" >or=30%" and basilar artery by high-resolution MRI was scored as "normal" or "presence of plaque." Medial pontine infarcts were divided into paramedian pontine infarction and small medial pontine lesion groups. Forty-one patients with pontine infarction were included, 26 with paramedian pontine infarction and 15 with small medial pontine lesion. High-resolution MRI detected basilar artery atherosclerosis in 42% of patients with a pontine infarction and normal basilar angiograms. Among patients with paramedian pontine infarction, 65% had normal basilar angiograms but 77% had basilar artery atherosclerosis detected on high-resolution MRI. Among patients with small medial pontine lesion, 46% had normal basilar angiograms but 73% had basilar artery plaques detected on by high-resolution MRI. This study suggests that medial pontine lacunes may be due to a penetrating artery disease secondary to basilar artery atherosclerosis. High-resolution MRI could help precise stroke subtyping.

Sensitivity of The High-resolution Wam Model With Respect To Time Step

NASA Astrophysics Data System (ADS)

Kasemets, K.; Soomere, T.

The northern part of the Baltic Proper and its subbasins (Bothnian Sea, the Gulf of Finland, Moonsund) serve as a challenge for wave modellers. In difference from the southern and the eastern parts of the Baltic Sea, their coasts are highly irregular and contain many peculiarities with the characteristic horizontal scale of the order of a few kilometres. For example, the northern coast of the Gulf of Finland is extremely ragged and contains a huge number of small islands. Its southern coast is more or less regular but has up to 50m high cliff that is frequently covered by high forests. The area also contains numerous banks that have water depth a couple of meters and that may essentially modify wave properties near the banks owing to topographical effects. This feature suggests that a high-resolution wave model should be applied for the region in question, with a horizontal resolution of an order of 1 km or even less. According to the Courant-Friedrich-Lewy criterion, the integration time step for such models must be of the order of a few tens of seconds. A high-resolution WAM model turns out to be fairly sensitive with respect to the particular choice of the time step. In our experiments, a medium-resolution model for the whole Baltic Sea was used, with the horizontal resolution 3 miles (3' along latitudes and 6' along longitudes) and the angular resolution 12 directions. The model was run with steady wind blowing 20 m/s from different directions and with two time steps (1 and 3 minutes). For most of the wind directions, the rms. difference of significant wave heights calculated with differ- ent time steps did not exceed 10 cm and typically was of the order of a few per cents. The difference arose within a few tens of minutes and generally did not increase in further computations. However, in the case of the north wind, the difference increased nearly monotonously and reached 25-35 cm (10-15%) within three hours of integra- tion whereas mean of significant wave heights over the whole Baltic Sea was 2.4 m (1 minute) and 2.04 m (3 minutes), respectively. The most probable reason of such difference is that the WAM model with a relatively large time step poorly describes wave field evolution in the Aland area with extremely ragged bottom topography and coastal line. In earlier studies, it has been reported that the WAM model frequently underestimates wave heights in the northern Baltic Proper by 20-30% in the case of strong north storms (Tuomi et al, Report series of the Finnish Institute of Marine Re- search, 1999). The described results suggest that a part of this underestimation may be removed through a proper choice of the time step.

Rayleigh-wave mode separation by high-resolution linear radon transform

USGS Publications Warehouse

Luo, Y.; Xia, J.; Miller, R.D.; Xu, Y.; Liu, J.; Liu, Q.

2009-01-01

Multichannel analysis of surface waves (MASW) method is an effective tool for obtaining vertical shear wave profiles from a single non-invasive measurement. One key step of the MASW method is generation of a dispersion image and extraction of a reliable dispersion curve from raw multichannel shot records. Because different Rayleigh-wave modes normally interfere with each other in the time and space domain, it is necessary to perform mode separation and reconstruction to increase the accuracy of phase velocities determined from a dispersion image. In this paper, we demonstrate the effectiveness of high-resolution linear Radon transform (LRT) as a means of separating and reconstructing multimode, dispersive Rayleigh-wave energy. We first introduce high-resolution LRT methods and Rayleigh-wave mode separation using high-resolution LRT. Next, we use synthetic data and a real-world example to demonstrate the effectiveness of Rayleigh-wave mode separation using high-resolution LRT. Our synthetic and real-world results demonstrate that (1) high-resolution LRT successfully separates and reconstructs multimode dispersive Rayleigh-wave energy with high resolution allowing the multimode energy to be more accurately determined. The horizontal resolution of the Rayleigh-wave method can be increased by extraction of dispersion curves from a pair of traces in the mode-separated shot gather and (2) multimode separation and reconstruction expand the usable frequency range of higher mode dispersive energy, which increases the depth of investigation and provides a means for accurately determining cut-off frequencies. ?? 2009 The Authors Journal compilation ?? 2009 RAS.

Architecture and applications of a high resolution gated SPAD image sensor

PubMed Central

Burri, Samuel; Maruyama, Yuki; Michalet, Xavier; Regazzoni, Francesco; Bruschini, Claudio; Charbon, Edoardo

2014-01-01

We present the architecture and three applications of the largest resolution image sensor based on single-photon avalanche diodes (SPADs) published to date. The sensor, fabricated in a high-voltage CMOS process, has a resolution of 512 × 128 pixels and a pitch of 24 μm. The fill-factor of 5% can be increased to 30% with the use of microlenses. For precise control of the exposure and for time-resolved imaging, we use fast global gating signals to define exposure windows as small as 4 ns. The uniformity of the gate edges location is ∼140 ps (FWHM) over the whole array, while in-pixel digital counting enables frame rates as high as 156 kfps. Currently, our camera is used as a highly sensitive sensor with high temporal resolution, for applications ranging from fluorescence lifetime measurements to fluorescence correlation spectroscopy and generation of true random numbers. PMID:25090572

Particle acceleration due to shocks in the interplanetary field: High time resolution data and simulation results

NASA Technical Reports Server (NTRS)

Kessel, R. L.; Armstrong, T. P.; Nuber, R.; Bandle, J.

1985-01-01

Data were examined from two experiments aboard the Explorer 50 (IMP 8) spacecraft. The Johns Hopkins University/Applied Lab Charged Particle Measurement Experiment (CPME) provides 10.12 second resolution ion and electron count rates as well as 5.5 minute or longer averages of the same, with data sampled in the ecliptic plane. The high time resolution of the data allows for an explicit, point by point, merging of the magnetic field and particle data and thus a close examination of the pre- and post-shock conditions and particle fluxes associated with large angle oblique shocks in the interplanetary field. A computer simulation has been developed wherein sample particle trajectories, taken from observed fluxes, are allowed to interact with a planar shock either forward or backward in time. One event, the 1974 Day 312 shock, is examined in detail.

Deep-tissue focal fluorescence imaging with digitally time-reversed ultrasound-encoded light

PubMed Central

Wang, Ying Min; Judkewitz, Benjamin; DiMarzio, Charles A.; Yang, Changhuei

2012-01-01

Fluorescence imaging is one of the most important research tools in biomedical sciences. However, scattering of light severely impedes imaging of thick biological samples beyond the ballistic regime. Here we directly show focusing and high-resolution fluorescence imaging deep inside biological tissues by digitally time-reversing ultrasound-tagged light with high optical gain (~5×105). We confirm the presence of a time-reversed optical focus along with a diffuse background—a corollary of partial phase conjugation—and develop an approach for dynamic background cancellation. To illustrate the potential of our method, we image complex fluorescent objects and tumour microtissues at an unprecedented depth of 2.5 mm in biological tissues at a lateral resolution of 36 μm×52 μm and an axial resolution of 657 μm. Our results set the stage for a range of deep-tissue imaging applications in biomedical research and medical diagnostics. PMID:22735456

Beamline P02.1 at PETRA III for high-resolution and high-energy powder diffraction

PubMed Central

Dippel, Ann-Christin; Liermann, Hanns-Peter; Delitz, Jan Torben; Walter, Peter; Schulte-Schrepping, Horst; Seeck, Oliver H.; Franz, Hermann

2015-01-01

Powder X-ray diffraction techniques largely benefit from the superior beam quality provided by high-brilliance synchrotron light sources in terms of photon flux and angular resolution. The High Resolution Powder Diffraction Beamline P02.1 at the storage ring PETRA III (DESY, Hamburg, Germany) combines these strengths with the power of high-energy X-rays for materials research. The beamline is operated at a fixed photon energy of 60 keV (0.207 Å wavelength). A high-resolution monochromator generates the highly collimated X-ray beam of narrow energy bandwidth. Classic crystal structure determination in reciprocal space at standard and non-ambient conditions are an essential part of the scientific scope as well as total scattering analysis using the real space information of the pair distribution function. Both methods are complemented by in situ capabilities with time-resolution in the sub-second regime owing to the high beam intensity and the advanced detector technology for high-energy X-rays. P02.1’s efficiency in solving chemical and crystallographic problems is illustrated by presenting key experiments that were carried out within these fields during the early stage of beamline operation. PMID:25931084

Controlled power delivery for super-resolution imaging of biological samples using digital micromirror device

NASA Astrophysics Data System (ADS)

Valiya Peedikakkal, Liyana; Cadby, Ashley

2017-02-01

Localization based super resolution images of a biological sample is generally achieved by using high power laser illumination with long exposure time which unfortunately increases photo-toxicity of a sample, making super resolution microscopy, in general, incompatible with live cell imaging. Furthermore, the limitation of photobleaching reduces the ability to acquire time lapse images of live biological cells using fluorescence microscopy. Digital Light Processing (DLP) technology can deliver light at grey scale levels by flickering digital micromirrors at around 290 Hz enabling highly controlled power delivery to samples. In this work, Digital Micromirror Device (DMD) is implemented in an inverse Schiefspiegler telescope setup to control the power and pattern of illumination for super resolution microscopy. We can achieve spatial and temporal patterning of illumination by controlling the DMD pixel by pixel. The DMD allows us to control the power and spatial extent of the laser illumination. We have used this to show that we can reduce the power delivered to the sample to allow for longer time imaging in one area while achieving sub-diffraction STORM imaging in another using higher power densities.

High time resolution measurements of rocket potential changes induced by electron beam emission

NASA Technical Reports Server (NTRS)

Raitt, W. J.; Myers, N. B.; Williamson, P. R.; Banks, P. M.; Kawashima, N.

1984-01-01

The transient charging and photon emission from the vacuum chamber testing of the Cooperative High Altitude Rocket Gun Experiment are studied. Graphs of the mother-daughter voltage versus time and high time resolution data related to the return current to the vehicle are examined. It is observed that for average sounding rocket densities of 10 to the -6th torr the slope of the voltage rise of the rocket begins to flatten 40 microsec after the onset of electron beam emission, and for higher gas pressure the rocket reaches a maximum voltage of 25 or 30 microsec after the onset of electron beam emission. The data reveal that the return current mechanism for the higher gas pressure is through the sheath.

Sensitivity and resolution in frequency comb spectroscopy of buffer gas cooled polyatomic molecules

NASA Astrophysics Data System (ADS)

Changala, P. Bryan; Spaun, Ben; Patterson, David; Doyle, John M.; Ye, Jun

2016-12-01

We discuss the use of cavity-enhanced direct frequency comb spectroscopy in the mid-infrared region with buffer gas cooling of polyatomic molecules for high-precision rovibrational absorption spectroscopy. A frequency comb coupled to an optical enhancement cavity allows us to collect high-resolution, broad-bandwidth infrared spectra of translationally and rotationally cold (10-20 K) gas-phase molecules with high absorption sensitivity and fast acquisition times. The design and performance of the combined apparatus are discussed in detail. Recorded rovibrational spectra in the CH stretching region of several organic molecules, including vinyl bromide (CH_2CHBr), adamantane (C_{10}H_{16}), and diamantane (C_{14}H_{20}) demonstrate the resolution and sensitivity of this technique, as well as the intrinsic challenges faced in extending the frontier of high-resolution spectroscopy to large complex molecules.

Turbulence imaging and applications using beam emission spectroscopy on DIII-D (invited)

NASA Astrophysics Data System (ADS)

McKee, G. R.; Fenzi, C.; Fonck, R. J.; Jakubowski, M.

2003-03-01

Two-dimensional measurements of density fluctuations are obtained in the radial and poloidal plane of the DIII-D tokamak with the Beam Emission Spectroscopy (BES) diagnostic system. The goals are to visualize the spatial structure and time evolution of turbulent eddies, as well as to obtain the 2D statistical properties of turbulence. The measurements are obtained with an array of localized BES spatial channels configured to image a midplane region of the plasma. 32 channels have been deployed, each with a spatial resolution of about 1 cm in the radial and poloidal directions, thus providing measurements of turbulence in the wave number range 0

Imaging the small animal cardiovascular system in real-time with multispectral optoacoustic tomography

NASA Astrophysics Data System (ADS)

Taruttis, Adrian; Herzog, Eva; Razansky, Daniel; Ntziachristos, Vasilis

2011-03-01

Multispectral Optoacoustic Tomography (MSOT) is an emerging technique for high resolution macroscopic imaging with optical and molecular contrast. We present cardiovascular imaging results from a multi-element real-time MSOT system recently developed for studies on small animals. Anatomical features relevant to cardiovascular disease, such as the carotid arteries, the aorta and the heart, are imaged in mice. The system's fast acquisition time, in tens of microseconds, allows images free of motion artifacts from heartbeat and respiration. Additionally, we present in-vivo detection of optical imaging agents, gold nanorods, at high spatial and temporal resolution, paving the way for molecular imaging applications.

High-resolution frequency domain second harmonic optical coherence tomography

NASA Astrophysics Data System (ADS)

Su, Jianping; Tomov, I. V.; Jiang, Yi; Chen, Zhongping

2007-02-01

We used continuum generated in an 8.5 cm long fiber by a femtosecond Yb fiber laser to improve threefold the axial resolution of frequency domain SH-OCT to 12μm. The acquisition time was shortened by more than two orders of magnitude compared to time domain SH-OCT. The system was applied to image biological tissue of fish scales, pig leg tendon and rabbit eye sclera. Highly organized collagen fibrils can be visualized in the recorded images. Polarization dependence on second harmonic has been used to obtain polarization resolved images.

Robust high-resolution quantification of time signals encoded by in vivo magnetic resonance spectroscopy

NASA Astrophysics Data System (ADS)

Belkić, Dževad; Belkić, Karen

2018-01-01

This paper on molecular imaging emphasizes improving specificity of magnetic resonance spectroscopy (MRS) for early cancer diagnostics by high-resolution data analysis. Sensitivity of magnetic resonance imaging (MRI) is excellent, but specificity is insufficient. Specificity is improved with MRS by going beyond morphology to assess the biochemical content of tissue. This is contingent upon accurate data quantification of diagnostically relevant biomolecules. Quantification is spectral analysis which reconstructs chemical shifts, amplitudes and relaxation times of metabolites. Chemical shifts inform on electronic shielding of resonating nuclei bound to different molecular compounds. Oscillation amplitudes in time signals retrieve the abundance of MR sensitive nuclei whose number is proportional to metabolite concentrations. Transverse relaxation times, the reciprocal of decay probabilities of resonances, arise from spin-spin coupling and reflect local field inhomogeneities. In MRS single voxels are used. For volumetric coverage, multi-voxels are employed within a hybrid of MRS and MRI called magnetic resonance spectroscopic imaging (MRSI). Common to MRS and MRSI is encoding of time signals and subsequent spectral analysis. Encoded data do not provide direct clinical information. Spectral analysis of time signals can yield the quantitative information, of which metabolite concentrations are the most clinically important. This information is equivocal with standard data analysis through the non-parametric, low-resolution fast Fourier transform and post-processing via fitting. By applying the fast Padé transform (FPT) with high-resolution, noise suppression and exact quantification via quantum mechanical signal processing, advances are made, presented herein, focusing on four areas of critical public health importance: brain, prostate, breast and ovarian cancers.

A compact high resolution flat panel PET detector based on the new 4-side buttable MPPC for biomedical applications

PubMed Central

Wang, Qiang; Wen, Jie; Ravindranath, Bosky; O’Sullivan, Andrew W.; Catherall, David; Li, Ke; Wei, Shouyi; Komarov, Sergey; Tai, Yuan-Chuan

2015-01-01

Compact high-resolution panel detectors using virtual pinhole (VP) PET geometry can be inserted into existing clinical or pre-clinical PET systems to improve regional spatial resolution and sensitivity. Here we describe a compact panel PET detector built using the new Though Silicon Via (TSV) multi-pixel photon counters (MPPC) detector. This insert provides high spatial resolution and good timing performance for multiple bio-medical applications. Because the TSV MPPC design eliminates wire bonding and has a package dimension which is very close to the MPPC’s active area, it is 4-side buttable. The custom designed MPPC array (based on Hamamatsu S12641-PA-50(x)) used in the prototype is composed of 4 × 4 TSV-MPPC cells with a 4.46 mm pitch in both directions. The detector module has 16 × 16 lutetium yttrium oxyorthosilicate (LYSO) crystal array, with each crystal measuring 0.92 × 0.92 × 3 mm3 with 1.0 mm pitch. The outer diameter of the detector block is 16.8 × 16.8 mm2. Thirty-two such blocks will be arranged in a 4 × 8 array with 1 mm gaps to form a panel detector with detection area around 7 cm × 14 cm in the full-size detector. The flood histogram acquired with Ge-68 source showed excellent crystal separation capability with all 256 crystals clearly resolved. The detector module’s mean, standard deviation, minimum (best) and maximum (worst) energy resolution were 10.19%, +/−0.68%, 8.36% and 13.45% FWHM, respectively. The measured coincidence time resolution between the block detector and a fast reference detector (around 200 ps single photon timing resolution) was 0.95 ns. When tested with Siemens Cardinal electronics the performance of the detector blocks remain consistent. These results demonstrate that the TSV-MPPC is a promising photon sensor for use in a flat panel PET insert composed of many high resolution compact detector modules. PMID:26085702

3.0-T functional brain imaging: a 5-year experience.

PubMed

Scarabino, T; Giannatempo, G M; Popolizio, T; Tosetti, M; d'Alesio, V; Esposito, F; Di Salle, F; Di Costanzo, A; Bertolino, A; Maggialetti, A; Salvolini, U

2007-02-01

The aim of this paper is to illustrate the technical, methodological and diagnostic features of functional imaging (comprising spectroscopy, diffusion, perfusion and cortical activation techniques) and its principal neuroradiological applications on the basis of the experience gained by the authors in the 5 years since the installation of a high-field magnetic resonance (MR) magnet. These MR techniques are particularly effective at 3.0 Tesla (T) owing to their high signal, resolution and sensitivity, reduced scanning times and overall improved diagnostic ability. In particular, the high-field strength enhances spectroscopic analysis due to a greater signal-to-noise ratio (SNR) and improved spectral, space and time resolution, resulting in the ability to obtain high-resolution spectroscopic studies not only of the more common metabolites, but also--and especially--of those which, due to their smaller concentrations, are difficult to detect using 1.5-T systems. All of these advantages can be obtained with reduced acquisition times. In diffusion studies, the high-field strength results in greater SNR, because 3.0-T magnets enable increased spatial resolution, which enhances accuracy. They also allow exploration in greater detail of more complex phenomena (such as diffusion tensor and tractography), which are not clearly depicted on 1.5-T systems. The most common perfusion study (with intravenous injection of a contrast agent) benefits from the greater SNR and higher magnetic susceptibility by achieving dramatically improved signal changes, and thus greater reliability, using smaller doses of contrast agent. Functional MR imaging (fMRI) is without doubt the modality in which high-field strength has had the greatest impact. Images acquired with the blood-oxygen-level-dependent (BOLD) technique benefit from the greater SNR afforded by 3.0-T magnets and from their stronger magnetic susceptibility effects, providing higher signal and spatial resolution. This enhances reliability of the localisation of brain functions, making it possible to map additional areas, even in the millimetre and submillimetre scale. The data presented and results obtained to date show that 3.0-T morphofunctional imaging can become the standard for high-resolution investigation of brain disease.

High resolution extensometer based on optical encoder for measurement of small landslide displacements

NASA Astrophysics Data System (ADS)

Afandi, M. I.; Adinanta, H.; Setiono, A.; Qomaruddin; Widiyatmoko, B.

2018-03-01

There are many ways to measure landslide displacement using sensors such as multi-turn potentiometer, fiber optic strain sensor, GPS, geodetic measurement, ground penetrating radar, etc. The proposed way is to use an optical encoder that produces pulse signal with high stability of measurement resolution despite voltage source instability. The landslide measurement using extensometer based on optical encoder has the ability of high resolution for wide range measurement and for a long period of time. The type of incremental optical encoder provides information about the pulse and direction of a rotating shaft by producing quadrature square wave cycle per increment of shaft movement. The result of measurement using 2,000 pulses per resolution of optical encoder has been obtained. Resolution of extensometer is 36 μm with speed limit of about 3.6 cm/s. System test in hazard landslide area has been carried out with good reliability for small landslide displacement monitoring.

IMART software for correction of motion artifacts in images collected in intravital microscopy

PubMed Central

Dunn, Kenneth W; Lorenz, Kevin S; Salama, Paul; Delp, Edward J

2014-01-01

Intravital microscopy is a uniquely powerful tool, providing the ability to characterize cell and organ physiology in the natural context of the intact, living animal. With the recent development of high-resolution microscopy techniques such as confocal and multiphoton microscopy, intravital microscopy can now characterize structures at subcellular resolution and capture events at sub-second temporal resolution. However, realizing the potential for high resolution requires remarkable stability in the tissue. Whereas the rigid structure of the skull facilitates high-resolution imaging of the brain, organs of the viscera are free to move with respiration and heartbeat, requiring additional apparatus for immobilization. In our experience, these methods are variably effective, so that many studies are compromised by residual motion artifacts. Here we demonstrate the use of IMART, a software tool for removing motion artifacts from intravital microscopy images collected in time series or in three dimensions. PMID:26090271

Radar/radiometer facilities for precipitation measurements

NASA Technical Reports Server (NTRS)

Hodge, D. B.; Taylor, R. C.

1973-01-01

The OSU ElectroScience Laboratory Radar/Radiometer Facilities are described. This instrumentation includes a high-resolution radar/radiometer system, a fully automated low-resolution radar system, and a small surveillance radar system. The high-resolution radar/radiometer system operates at 3, 9, and 15 GHz using two 9.1 m and one 4.6 m parabolic antennas, respectively. The low-resolution and surveillance radars operate at 9 and 15 GHz, respectively. Both the high- and low-resolution systems are interfaced to real-time digital processing and recording systems. This capability was developed for the measurement of the temporal and spatial characteristics of precipitation in conjunction with millimeter wavelength propagation studies utilizing the Advanced Technology Satellites. Precipitation characteristics derived from these measurements could also be of direct benefit in such diverse areas as: the atmospheric sciences, meteorology, water resources, flood control and warning, severe storm warning, agricultural crop studies, and urban and regional planning.

High resolution propagation-based imaging system for in vivo dynamic computed tomography of lungs in small animals

NASA Astrophysics Data System (ADS)

Preissner, M.; Murrie, R. P.; Pinar, I.; Werdiger, F.; Carnibella, R. P.; Zosky, G. R.; Fouras, A.; Dubsky, S.

2018-04-01

We have developed an x-ray imaging system for in vivo four-dimensional computed tomography (4DCT) of small animals for pre-clinical lung investigations. Our customized laboratory facility is capable of high resolution in vivo imaging at high frame rates. Characterization using phantoms demonstrate a spatial resolution of slightly below 50 μm at imaging rates of 30 Hz, and the ability to quantify material density differences of at least 3%. We benchmark our system against existing small animal pre-clinical CT scanners using a quality factor that combines spatial resolution, image noise, dose and scan time. In vivo 4DCT images obtained on our system demonstrate resolution of important features such as blood vessels and small airways, of which the smallest discernible were measured as 55–60 μm in cross section. Quantitative analysis of the images demonstrate regional differences in ventilation between injured and healthy lungs.

Development of High-Resolution Dynamic Dust Source Function - A Case Study with a Strong Dust Storm in a Regional Model

NASA Technical Reports Server (NTRS)

Kim, Dongchul; Chin, Mian; Kemp, Eric M.; Tao, Zhining; Peters-Lidard, Christa D.; Ginoux, Paul

2017-01-01

A high-resolution dynamic dust source has been developed in the NASA Unified-Weather Research and Forecasting (NU-WRF) model to improve the existing coarse static dust source. In the new dust source map, topographic depression is in 1-km resolution and surface bareness is derived using the Normalized Difference Vegetation Index (NDVI) data from Moderate Resolution Imaging Spectroradiometer (MODIS). The new dust source better resolves the complex topographic distribution over the Western United States where its magnitude is higher than the existing, coarser resolution static source. A case study is conducted with an extreme dust storm that occurred in Phoenix, Arizona in 0203 UTC July 6, 2011. The NU-WRF model with the new high-resolution dynamic dust source is able to successfully capture the dust storm, which was not achieved with the old source identification. However the case study also reveals several challenges in reproducing the time evolution of the short-lived, extreme dust storm events.

Development of High-Resolution Dynamic Dust Source Function -A Case Study with a Strong Dust Storm in a Regional Model

PubMed Central

Kim, Dongchul; Chin, Mian; Kemp, Eric M.; Tao, Zhining; Peters-Lidard, Christa D.; Ginoux, Paul

2018-01-01

A high-resolution dynamic dust source has been developed in the NASA Unified-Weather Research and Forecasting (NU-WRF) model to improve the existing coarse static dust source. In the new dust source map, topographic depression is in 1-km resolution and surface bareness is derived using the Normalized Difference Vegetation Index (NDVI) data from Moderate Resolution Imaging Spectroradiometer (MODIS). The new dust source better resolves the complex topographic distribution over the Western United States where its magnitude is higher than the existing, coarser resolution static source. A case study is conducted with an extreme dust storm that occurred in Phoenix, Arizona in 02-03 UTC July 6, 2011. The NU-WRF model with the new high-resolution dynamic dust source is able to successfully capture the dust storm, which was not achieved with the old source identification. However the case study also reveals several challenges in reproducing the time evolution of the short-lived, extreme dust storm events. PMID:29632432

Development of High-Resolution Dynamic Dust Source Function -A Case Study with a Strong Dust Storm in a Regional Model.

PubMed

Kim, Dongchul; Chin, Mian; Kemp, Eric M; Tao, Zhining; Peters-Lidard, Christa D; Ginoux, Paul

2017-06-01

A high-resolution dynamic dust source has been developed in the NASA Unified-Weather Research and Forecasting (NU-WRF) model to improve the existing coarse static dust source. In the new dust source map, topographic depression is in 1-km resolution and surface bareness is derived using the Normalized Difference Vegetation Index (NDVI) data from Moderate Resolution Imaging Spectroradiometer (MODIS). The new dust source better resolves the complex topographic distribution over the Western United States where its magnitude is higher than the existing, coarser resolution static source. A case study is conducted with an extreme dust storm that occurred in Phoenix, Arizona in 02-03 UTC July 6, 2011. The NU-WRF model with the new high-resolution dynamic dust source is able to successfully capture the dust storm, which was not achieved with the old source identification. However the case study also reveals several challenges in reproducing the time evolution of the short-lived, extreme dust storm events.

Improving PET spatial resolution and detectability for prostate cancer imaging

NASA Astrophysics Data System (ADS)

Bal, H.; Guerin, L.; Casey, M. E.; Conti, M.; Eriksson, L.; Michel, C.; Fanti, S.; Pettinato, C.; Adler, S.; Choyke, P.

2014-08-01

Prostate cancer, one of the most common forms of cancer among men, can benefit from recent improvements in positron emission tomography (PET) technology. In particular, better spatial resolution, lower noise and higher detectability of small lesions could be greatly beneficial for early diagnosis and could provide a strong support for guiding biopsy and surgery. In this article, the impact of improved PET instrumentation with superior spatial resolution and high sensitivity are discussed, together with the latest development in PET technology: resolution recovery and time-of-flight reconstruction. Using simulated cancer lesions, inserted in clinical PET images obtained with conventional protocols, we show that visual identification of the lesions and detectability via numerical observers can already be improved using state of the art PET reconstruction methods. This was achieved using both resolution recovery and time-of-flight reconstruction, and a high resolution image with 2 mm pixel size. Channelized Hotelling numerical observers showed an increase in the area under the LROC curve from 0.52 to 0.58. In addition, a relationship between the simulated input activity and the area under the LROC curve showed that the minimum detectable activity was reduced by more than 23%.

Modeling fire behavior on tropical islands with high-resolution weather data

Treesearch

John W. Benoit; Francis M. Fujioka; David R. Weise

2009-01-01

In this study, we consider fire behavior simulation in tropical island scenarios such as Hawaii and Puerto Rico. The development of a system to provide real-time fire behavior prediction in Hawaii is discussed. This involves obtaining fuels and topography information at a fine scale, as well as supplying daily high-resolution weather forecast data for the area of...

Parallel Spectral Acquisition with an Ion Cyclotron Resonance Cell Array.

PubMed

Park, Sung-Gun; Anderson, Gordon A; Navare, Arti T; Bruce, James E

2016-01-19

Mass measurement accuracy is a critical analytical figure-of-merit in most areas of mass spectrometry application. However, the time required for acquisition of high-resolution, high mass accuracy data limits many applications and is an aspect under continual pressure for development. Current efforts target implementation of higher electrostatic and magnetic fields because ion oscillatory frequencies increase linearly with field strength. As such, the time required for spectral acquisition of a given resolving power and mass accuracy decreases linearly with increasing fields. Mass spectrometer developments to include multiple high-resolution detectors that can be operated in parallel could further decrease the acquisition time by a factor of n, the number of detectors. Efforts described here resulted in development of an instrument with a set of Fourier transform ion cyclotron resonance (ICR) cells as detectors that constitute the first MS array capable of parallel high-resolution spectral acquisition. ICR cell array systems consisting of three or five cells were constructed with printed circuit boards and installed within a single superconducting magnet and vacuum system. Independent ion populations were injected and trapped within each cell in the array. Upon filling the array, all ions in all cells were simultaneously excited and ICR signals from each cell were independently amplified and recorded in parallel. Presented here are the initial results of successful parallel spectral acquisition, parallel mass spectrometry (MS) and MS/MS measurements, and parallel high-resolution acquisition with the MS array system.

Optical Imaging with a High Resolution Microendoscope to Identify Cholesteatoma of the Middle Ear

PubMed Central

Levy, Lauren L.; Jiang, Nancy; Smouha, Eric; Richards-Kortum, Rebecca; Sikora, Andrew G.

2013-01-01

Objective High resolution optical imaging is an imaging modality which allows visualization of structural changes in epithelial tissue in real time. Our prior studies using contrast-enhanced microendoscopy to image squamous cell carcinoma in the head and neck demonstrated that the contrast agent, proflavine, has high affinity for keratinized tissue. Thus, high-resolution microendoscopy with proflavine provides a potential mechanism to identify ectopic keratin production, such as that associated with cholesteatoma formation and distinguish between uninvolved mucosa and residual keratin at the time of surgery. Study Design Ex vivo imaging of histopathologically-confirmed samples of cholesteatoma and uninvolved middle-ear epithelium. Methods Seven separate specimens collected from patients who underwent surgical treatment for cholesteatoma were imaged ex vivo with the fiberoptic endoscope after surface staining with proflavine. Following imaging, the specimens were submitted for hematoxylin &eosin staining to allow histopathological correlation. Results Cholesteatoma and surrounding middle ear epithelium have distinct imaging characteristics. Keratin-bearing areas of cholesteatoma lack nuclei and appear as confluent hyperfluorescence, while nuclei are easily visualized in specimens containing normal middle ear epithelium. Hyperfluorescence and loss of cellular detail is the imaging hallmark of keratin allowing for discrimination of cholesteatoma from normal middle ear epithelium. Conclusions This study demonstrates the feasibility of high-resolution optical imaging to discriminate cholesteatoma from uninvolved middle ear mucosa, based on the unique staining properties of keratin. Use of real-time imaging may facilitate more complete extirpation of cholesteatoma by identifying areas of residual disease. PMID:23299781

Spatiotemporal analysis of turbulent jets enabled by 100-kHz, 100-ms burst-mode particle image velocimetry

NASA Astrophysics Data System (ADS)

Miller, Joseph D.; Jiang, Naibo; Slipchenko, Mikhail N.; Mance, Jason G.; Meyer, Terrence R.; Roy, Sukesh; Gord, James R.

2016-12-01

100-kHz particle image velocimetry (PIV) is demonstrated using a double-pulsed, burst-mode laser with a burst duration up to 100 ms. This enables up to 10,000 time-sequential vector fields for capturing a temporal dynamic range spanning over three orders of magnitude in high-speed turbulent flows. Pulse doublets with inter-pulse spacing of 2 µs and repetition rate of 100 kHz are generated using a fiber-based oscillator and amplified through an all-diode-pumped, burst-mode amplifier. A physics-based model of pulse doublet amplification in the burst-mode amplifier is developed and used to accurately predict oscillator pulse width and pulse intensity inputs required to generate equal-energy pulse doublets at 532 nm for velocity measurements. The effect of PIV particle response and high-speed-detector limitations on the spatial and temporal resolution are estimated in subsonic turbulent jets. An effective spatial resolution of 266-275 µm and temporal resolution of 10 µs are estimated from the 8 × 8 pixel correlation window and inter-doublet time spacing, respectively. This spatiotemporal resolution is sufficient for quantitative assessment of integral time and length scales in highly turbulent jets with Reynolds numbers in the range 15,000-50,000. The temporal dynamic range of the burst-mode PIV measurement is 1200, limited by the 85-ms high-energy portion of the burst and 30-kHz high-frequency noise limit.

Characterization of Chemical Composition of Pericarpium Citri Reticulatae Volatile Oil by Comprehensive Two-Dimensional Gas Chromatography with High-Resolution Time-of-Flight Mass Spectrometry.

PubMed

Qin, Kunming; Zheng, Lijuan; Cai, Hao; Cao, Gang; Lou, Yajing; Lu, Tulin; Shu, Yachun; Zhou, Wei; Cai, Baochang

2013-01-01

Pericarpium Citri Reticulatae (Chenpi in Chinese) has been widely used as an herbal medicine in Korea, China, and Japan. Chenpi extracts are used to treat indigestion and inflammatory syndromes of the respiratory tract such as bronchitis and asthma. This thesis will analyze chemical compositions of Chenpi volatile oil, which was performed by comprehensive two-dimensional gas chromatography with high-resolution time-of-flight mass spectrometry (GC × GC-HR-TOFMS). One hundred and sixty-seven components were tentatively identified, and terpene compounds are the main components of Chenpi volatile oil, a significant larger number than in previous studies. The majority of the eluted compounds, which were identified, were well separated as a result of high-resolution capability of the GC × GC method, which significantly reduces, the coelution. β -Elemene is tentatively qualified by means of GC × GC in tandem with high-resolution TOFMS detection, which plays an important role in enhancing the effects of many anticancer drugs and in reducing the side effects of chemotherapy. This study suggests that GC × GC-HR-TOFMS is suitable for routine characterization of chemical composition of volatile oil in herbal medicines.

STROBE-X: X-ray Timing & Spectroscopy on Dynamical Timescales from Milliseconds to Years

NASA Technical Reports Server (NTRS)

Wilson-Hodge, Colleen A.; Ray, P. S.; Maccarone, T; Chakrabarty, D.; Gendreau, K.; Arzoumanian, Z.; Jenke, P.; Ballantyne, D.; Bozzo, E.; Brandt, S.;

STROBE-X: X-Ray Timing Spectroscopy on Dynamical Timescales from Microseconds to Years

NASA Technical Reports Server (NTRS)

Wilson-Hodge, Colleen A.; Ray, P. S.; Gendreau, K.; Arzoumanian, Z.; Chakrabarty, D.; Remillard, R.; Feroci, M.; Maccarone, T.; Wood, K.; Jenke, P.

2017-01-01

We describe a probe-class mission concept that provides an unprecedented view of the X-ray sky, performing timing and 0.2-30 keV spectroscopy over timescales from microseconds to years. The Spectroscopic Time-Resolving Observatory for Broadband Energy X-rays (STROBE-X) comprises three primary instruments. The first uses an array of lightweight optics (3-m focal length) that concentrate incident photons onto solid state detectors with CCD-level (85-130 eV) energy resolution, 100 ns time resolution, and low background rates to cover the 0.2-12 keV band. This technology is scaled up from NICER, with enhanced optics to take advantage of the longer focal length of STROBE-X. The second uses large-area collimated silicon drift detectors, developed for ESA's LOFT, to cover the 2-30 keV band. These two instruments each provide an order of magnitude improvement in effective area compared with its predecessor (NICER and RXTE, respectively). Finally, a sensitive sky monitor triggers pointed observations, provides high duty cycle, high time resolution, high spectral resolution monitoring of the X-ray sky with approx. 20 times the sensitivity of the RXTE ASM, and enables multi-wavelength and multi-messenger studies on a continuous, rather than scanning basis.For the first time, the broad coverage provides simultaneous study of thermal components, non-thermal components, iron lines, and reflection features from a single platform for accreting black holes at all scales. The enormous collecting area allows detailed studies of the dense matter equation of state using both thermal emission from rotation-powered pulsars and harder emission from X-ray burst oscillations. The combination of the wide-field monitor and the sensitive pointed instruments enables observations of potential electromagnetic counterparts to LIGO and neutrino events. Additional extragalactic science, such as high quality spectroscopy of clusters of galaxies and unprecedented timing investigations of active galactic nuclei, is also obtained.

STROBE-X: X-ray Timing & Spectroscopy on Dynamical Timescales from Microseconds to Years

NASA Astrophysics Data System (ADS)

Wilson-Hodge, Colleen A.; Ray, Paul S.; Gendreau, Keith; Chakrabarty, Deepto; Feroci, Marco; Maccarone, Thomas J.; Arzoumanian, Zaven; Remillard, Ronald A.; Wood, Kent; Griffith, Christopher; Jenke, Peter

2017-08-01

We describe a probe-class mission concept that provides an unprecedented view of the X-ray sky, performing timing and 0.2-30 keV spectroscopy over timescales from microseconds to years. The Spectroscopic Time-Resolving Observatory for Broadband Energy X-rays (STROBE-X) comprises three primary instruments. The first uses an array of lightweight optics (3-m focal length) that concentrate incident photons onto solid state detectors with CCD-level (85-130 eV) energy resolution, 100 ns time resolution, and low background rates to cover the 0.2-12 keV band. This technology is scaled up from NICER, with enhanced optics to take advantage of the longer focal length of STROBE-X. The second uses large-area collimated silicon drift detectors, developed for ESA's LOFT, to cover the 2-30 keV band. These two instruments each provide an order of magnitude improvement in effective area compared with its predecessor (NICER and RXTE, respectively). Finally, a sensitive sky monitor triggers pointed observations, provides high duty cycle, high time resolution, high spectral resolution monitoring of the X-ray sky with ~20 times the sensitivity of the RXTE ASM, and enables multi-wavelength and multi-messenger studies on a continuous, rather than scanning basis.For the first time, the broad coverage provides simultaneous study of thermal components, non-thermal components, iron lines, and reflection features from a single platform for accreting black holes at all scales. The enormous collecting area allows detailed studies of the dense matter equation of state using both thermal emission from rotation-powered pulsars and harder emission from X-ray burst oscillations. The combination of the wide-field monitor and the sensitive pointed instruments enables observations of potential electromagnetic counterparts to LIGO and neutrino events. Additional extragalactic science, such as high quality spectroscopy of clusters of galaxies and unprecedented timing investigations of active galactic nuclei, is also obtained.

High-resolution Rainfall Mapping in Dallas-Fort Worth (DFW) Urban Network of Radars at Multiple Frequencies

NASA Astrophysics Data System (ADS)

Chandra, Chandrasekar V.; Chen*, Haonan

2015-04-01

Urban flash flood is one of the most commonly encountered hazardous weather phenomena. Unfortunately, the rapid urbanization has made the densely populated areas even more vulnerable to flood risks. Hence, accurate and timely monitoring of rainfall at high spatiotemporal resolution is critical to severe weather warning and civil defense, especially in urban areas. However, it is still challenging to produce high-resolution products based on the large S-band National Weather Service (NWS) Next-Generation Weather Radar (NEXRAD), due to the sampling limitations and Earth curvature effect. Since 2012, the U.S. National Science Foundation Engineering Research Center (NSF-ERC) for Collaborative Adaptive Sensing of the Atmosphere (CASA) has initiated the development of Dallas-Fort Worth (DFW) radar remote sensing network for urban weather hazards mitigation. The DFW urban radar network consists of a combination of high-resolution X-band radars and a standard NWS NEXRAD radar operating at S-band frequency. High-resolution quantitative precipitation estimation (QPE) is one of the major research goals in the deployment of this urban radar network. It has been shown in the literature that the dual-polarization radar techniques can improve the QPE accuracy over traditional single-polarization radars by rendering more measurements to enhance the data quality, providing more information about rain drop size distribution (DSD), and implying more characteristics of different hydrometeor types. This paper will present the real-time dual-polarization CASA DFW QPE system, which is developed via fusion of observations from both the high-resolution X band radar network and the S-band NWS radar. The specific dual-polarization rainfall algorithms at different frequencies (i.e., S- and X-band) will be described in details. In addition, the fusion methodology combining observations at different temporal resolution will be presented. In order to demonstrate the capability of rainfall estimation of the CASA DFW QPE system, rainfall measurements from ground rain gauges will be used for evaluation purposes. This high-resolution QPE system is used for urban flash flood forecasting when coupled with hydrological models.

Developing Local Scale, High Resolution, Data to Interface with Numerical Storm Models

NASA Astrophysics Data System (ADS)

Witkop, R.; Becker, A.; Stempel, P.

2017-12-01

High resolution, physical storm models that can rapidly predict storm surge, inundation, rainfall, wind velocity and wave height at the intra-facility scale for any storm affecting Rhode Island have been developed by Researchers at the University of Rhode Island's (URI's) Graduate School of Oceanography (GSO) (Ginis et al., 2017). At the same time, URI's Marine Affairs Department has developed methods that inhere individual geographic points into GSO's models and enable the models to accurately incorporate local scale, high resolution data (Stempel et al., 2017). This combination allows URI's storm models to predict any storm's impacts on individual Rhode Island facilities in near real time. The research presented here determines how a coastal Rhode Island town's critical facility managers (FMs) perceive their assets as being vulnerable to quantifiable hurricane-related forces at the individual facility scale and explores methods to elicit this information from FMs in a format usable for incorporation into URI's storm models.

High-speed X-ray microscopy by use of high-resolution zone plates and synchrotron radiation.

PubMed

Hou, Qiyue; Wang, Zhili; Gao, Kun; Pan, Zhiyun; Wang, Dajiang; Ge, Xin; Zhang, Kai; Hong, Youli; Zhu, Peiping; Wu, Ziyu

2012-09-01

X-ray microscopy based on synchrotron radiation has become a fundamental tool in biology and life sciences to visualize the morphology of a specimen. These studies have particular requirements in terms of radiation damage and the image exposure time, which directly determines the total acquisition speed. To monitor and improve these key parameters, we present a novel X-ray microscopy method using a high-resolution zone plate as the objective and the matching condenser. Numerical simulations based on the scalar wave field theory validate the feasibility of the method and also indicate the performance of X-ray microscopy is optimized most with sub-10-nm-resolution zone plates. The proposed method is compatible with conventional X-ray microscopy techniques, such as computed tomography, and will find wide applications in time-resolved and/or dose-sensitive studies such as living cell imaging.

Development of high resolution simulations of the atmospheric environment using the MASS model

NASA Technical Reports Server (NTRS)

Kaplan, Michael L.; Zack, John W.; Karyampudi, V. Mohan

1989-01-01

Numerical simulations were performed with a very high resolution (7.25 km) version of the MASS model (Version 4.0) in an effort to diagnose the vertical wind shear and static stability structure during the Shuttle Challenger disaster which occurred on 28 January 1986. These meso-beta scale simulations reveal that the strongest vertical wind shears were concentrated in the 200 to 150 mb layer at 1630 GMT, i.e., at about the time of the disaster. These simulated vertical shears were the result of two primary dynamical processes. The juxtaposition of both of these processes produced a shallow (30 mb deep) region of strong vertical wind shear, and hence, low Richardson number values during the launch time period. Comparisons with the Cape Canaveral (XMR) rawinsonde indicates that the high resolution MASS 4.0 simulation more closely emulated nature than did previous simulations of the same event with the GMASS model.

Development of Residual Gas Profile Monitors at GSI

NASA Astrophysics Data System (ADS)

Giacomini, T.; Barabin, S.; Forck, P.; Liakin, D.; Skachkov, V.

2004-11-01

Beam profile measurements at modern ion synchrotrons and storage rings require high timing performances on a turn-by-turn basis. High spatial resolutions are essential for cold beams and beamwidth measurings. The currently used RGM supported very interesting measurements and applications. Due to the readout technology the spatial and time resolution is limited. To meet the expanded demands a more comprehensive device is under development. It will be an all-purpose residual gas monitor to cover the wide range of beam currents and transversal particle distributions. Due to the fast profile detection it will operate on primary electrons after residual gas ionization. A magnetic field of 100 mT binds them to the ionization point inside 0.1-mm orbits. The high-resolution mode will be read out by a digital CCD camera with an upstream MCP-phosphor screen assembly. It is planned to read out the fast turn-by-turn mode by an array of 100 photodiodes with a resolution of 1 mm. Every photodiode is equipped with an amplifier-digitizer device providing a frame rate of ˜ 10 MSamples/s.

Mixel camera--a new push-broom camera concept for high spatial resolution keystone-free hyperspectral imaging.

PubMed

Høye, Gudrun; Fridman, Andrei

2013-05-06

Current high-resolution push-broom hyperspectral cameras introduce keystone errors to the captured data. Efforts to correct these errors in hardware severely limit the optical design, in particular with respect to light throughput and spatial resolution, while at the same time the residual keystone often remains large. The mixel camera solves this problem by combining a hardware component--an array of light mixing chambers--with a mathematical method that restores the hyperspectral data to its keystone-free form, based on the data that was recorded onto the sensor with large keystone. A Virtual Camera software, that was developed specifically for this purpose, was used to compare the performance of the mixel camera to traditional cameras that correct keystone in hardware. The mixel camera can collect at least four times more light than most current high-resolution hyperspectral cameras, and simulations have shown that the mixel camera will be photon-noise limited--even in bright light--with a significantly improved signal-to-noise ratio compared to traditional cameras. A prototype has been built and is being tested.

High resolution hard X-ray spectra of solar and cosmic sources. Ph.D. Thesis

NASA Technical Reports Server (NTRS)

Schwartz, R. A.

1984-01-01

High resolution hard X-ray observations of a large solar flare and the Crab Nebula were obtained during balloon flights using an array of cooled germanium planar detectors. In addition, high time resolution high sensitivity measurements were obtained with a 300 square cm NaI/CsI phoswich scintillator. The Crab spectrum from both flights was searched without finding evidence of line emission below 200 keV. In particular, for the 73 keV line previously reported a 3 sigma upper limit for a narrow (1 keV FWHM) line .0019 and .0014 ph square cm/sec for the 1979 and 1980 flights, respectively was obtained.

High-resolution mapping based on an Unmanned Aerial Vehicle (UAV) to capture paleoseismic offsets along the Altyn-Tagh fault, China.

PubMed

Gao, Mingxing; Xu, Xiwei; Klinger, Yann; van der Woerd, Jerome; Tapponnier, Paul

2017-08-15

The recent dramatic increase in millimeter- to centimeter- resolution topographic datasets obtained via multi-view photogrammetry raises the possibility of mapping detailed offset geomorphology and constraining the spatial characteristics of active faults. Here, for the first time, we applied this new method to acquire high-resolution imagery and generate topographic data along the Altyn Tagh fault, which is located in a remote high elevation area and shows preserved ancient earthquake surface ruptures. A digital elevation model (DEM) with a resolution of 0.065 m and an orthophoto with a resolution of 0.016 m were generated from these images. We identified piercing markers and reconstructed offsets based on both the orthoimage and the topography. The high-resolution UAV data were used to accurately measure the recent seismic offset. We obtained the recent offset of 7 ± 1 m. Combined with the high resolution satellite image, we measured cumulative offsets of 15 ± 2 m, 20 ± 2 m, 30 ± 2 m, which may be due to multiple paleo-earthquakes. Therefore, UAV mapping can provide fine-scale data for the assessment of the seismic hazards.

Retinal optical coherence tomography at 1 μm with dynamic focus control and axial motion tracking

NASA Astrophysics Data System (ADS)

Cua, Michelle; Lee, Sujin; Miao, Dongkai; Ju, Myeong Jin; Mackenzie, Paul J.; Jian, Yifan; Sarunic, Marinko V.

2016-02-01

High-resolution optical coherence tomography (OCT) retinal imaging is important to noninvasively visualize the various retinal structures to aid in better understanding of the pathogenesis of vision-robbing diseases. However, conventional OCT systems have a trade-off between lateral resolution and depth-of-focus. In this report, we present the development of a focus-stacking OCT system with automatic focus optimization for high-resolution, extended-focal-range clinical retinal imaging by incorporating a variable-focus liquid lens into the sample arm optics. Retinal layer tracking and selection was performed using a graphics processing unit accelerated processing platform for focus optimization, providing real-time layer-specific en face visualization. After optimization, multiple volumes focused at different depths were acquired, registered, and stitched together to yield a single, high-resolution focus-stacked dataset. Using this system, we show high-resolution images of the retina and optic nerve head, from which we extracted clinically relevant parameters such as the nerve fiber layer thickness and lamina cribrosa microarchitecture.

Retinal optical coherence tomography at 1 μm with dynamic focus control and axial motion tracking.

PubMed

Cua, Michelle; Lee, Sujin; Miao, Dongkai; Ju, Myeong Jin; Mackenzie, Paul J; Jian, Yifan; Sarunic, Marinko V

2016-02-01

High-resolution optical coherence tomography (OCT) retinal imaging is important to noninvasively visualize the various retinal structures to aid in better understanding of the pathogenesis of vision-robbing diseases. However, conventional OCT systems have a trade-off between lateral resolution and depth-of-focus. In this report, we present the development of a focus-stacking OCT system with automatic focus optimization for high-resolution, extended-focal-range clinical retinal imaging by incorporating a variable-focus liquid lens into the sample arm optics. Retinal layer tracking and selection was performed using a graphics processing unit accelerated processing platform for focus optimization, providing real-time layer-specific en face visualization. After optimization, multiple volumes focused at different depths were acquired, registered, and stitched together to yield a single, high-resolution focus-stacked dataset. Using this system, we show high-resolution images of the retina and optic nerve head, from which we extracted clinically relevant parameters such as the nerve fiber layer thickness and lamina cribrosa microarchitecture.

Rayleigh-wave dispersive energy imaging using a high-resolution linear radon transform

USGS Publications Warehouse

Luo, Y.; Xia, J.; Miller, R.D.; Xu, Y.; Liu, J.; Liu, Q.

2008-01-01

Multichannel Analysis of Surface Waves (MASW) analysis is an efficient tool to obtain the vertical shear-wave profile. One of the key steps in the MASW method is to generate an image of dispersive energy in the frequency-velocity domain, so dispersion curves can be determined by picking peaks of dispersion energy. In this paper, we propose to image Rayleigh-wave dispersive energy by high-resolution linear Radon transform (LRT). The shot gather is first transformed along the time direction to the frequency domain and then the Rayleigh-wave dispersive energy can be imaged by high-resolution LRT using a weighted preconditioned conjugate gradient algorithm. Synthetic data with a set of linear events are presented to show the process of generating dispersive energy. Results of synthetic and real-world examples demonstrate that, compared with the slant stacking algorithm, high-resolution LRT can improve the resolution of images of dispersion energy by more than 50%. ?? Birkhaueser 2008.

The 'fine structure' of nutrient dynamics in rivers: ten years of study using high-frequency monitoring

NASA Astrophysics Data System (ADS)

Jordan, Phil; Melland, Alice; Shore, Mairead; Mellander, Per-Erik; Shortle, Ger; Ryan, David; Crockford, Lucy; Macintosh, Katrina; Campbell, Julie; Arnscheidt, Joerg; Cassidy, Rachel

2014-05-01

A complete appraisal of material fluxes in flowing waters is really only possibly with high time resolution data synchronous with measurements of discharge. Defined by Kirchner et al. (2004; Hydrological Processes, 18/7) as the high-frequency wave of the future and with regard to disentangling signal noise from process pattern, this challenge has been met in terms of nutrient flux monitoring by automated bankside analysis. In Ireland over a ten-year period, time-series nutrient data collected on a sub-hourly basis in rivers have been used to distinguish fluxes from different catchment sources and pathways and to provide more certain temporal pictures of flux for the comparative definition of catchment nutrient dynamics. In catchments where nutrient fluxes are particularly high and exhibit a mix of extreme diffuse and point source influences, high time resolution data analysis indicates that there are no satisfactory statistical proxies for seasonal or annual flux predictions that use coarse datasets. Or at least exposes the limits of statistical approaches to catchment scale and hydrological response. This has profound implications for catchment monitoring programmes that rely on modelled relationships. However, using high resolution monitoring for long term assessments of catchment mitigation measures comes with further challenges. Sustaining continuous wet chemistry analysis at river stations is resource intensive in terms of capital, maintenance and quality assurance. Furthermore, big data capture requires investment in data management systems and analysis. These two institutional challenges are magnified when considering the extended time period required to identify the influences of land-based nutrient control measures on water based systems. Separating the 'climate signal' from the 'source signal' in river nutrient flux data is a major analysis challenge; more so when tackled with anything but higher resolution data. Nevertheless, there is scope to lower costs in bankside analysis through technology development, and the scientific advantages of these data are clear and exciting. When integrating its use with policy appraisal, it must be made clear that the advances in river process understanding from high resolution monitoring data capture come as a package with the ability to make more informed decisions through an investment in better information.

Full-field OCT: ex vivo and in vivo biological imaging applications

NASA Astrophysics Data System (ADS)

Grieve, Katharine; Dubois, Arnaud; Moneron, Gael; Guyot, Elvire; Boccara, Albert C.

2005-04-01

We present results of studies in embryology and ophthalmology performed using our ultrahigh-resolution full-field OCT system. We also discuss recent developments to our ultrashort acquisition time full-field optical coherence tomography system designed to allow in vivo biological imaging. Preliminary results of high-speed imaging in biological samples are presented. The core of the experimental setup is the Linnik interferometer, illuminated by a white light source. En face tomographic images are obtained in real-time without scanning by computing the difference of two phase-opposed interferometric images recorded by high-resolution CCD cameras. An isotropic spatial resolution of ~1 μm is achieved thanks to the short source coherence length and the use of high numerical aperture microscope objectives. A detection sensitivity of ~90 dB is obtained by means of image averaging and pixel binning. In ophthalmology, reconstructed xz images from rat ocular tissue are presented, where cellular-level structures in the retina are revealed, demonstrating the unprecedented resolution of our instrument. Three-dimensional reconstructions of the mouse embryo allowing the study of the establishment of the anterior-posterior axis are shown. Finally we present the first results of embryonic imaging using the new rapid acquisition full-field OCT system, which offers an acquisition time of 10 μs per frame.

High time resolution characteristics of intermediate ion distributions upstream of the earth's bow shock

NASA Technical Reports Server (NTRS)

Potter, D. W.

1985-01-01

High time resolution particle data upstream of the bow shock during time intervals that have been identified as having intermediate ion distributions often show high amplitude oscillations in the ion fluxes of energy 2 and 6 keV. These ion oscillations, observed with the particle instruments of the University of California, Berkeley, on the ISEE 1 and 2 spacecraft, are at the same frequency (about 0.04 Hz) as the magnetic field oscillations. Typically, the 6-keV ion flux increases then the 2-keV flux increases followed by a decrease in the 2-keV flux and then the 6-keV flux decreases. This process repeats many times. Although there is no entirely satisfactory explanation, the presence of these ion flux oscillations suggests that distributions often are misidentified as intermediate ion distributions.

A micron resolution optical scanner for characterization of silicon detectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shukla, R. A.; Dugad, S. R., E-mail: dugad@cern.ch; Gopal, A. V.

2014-02-15

The emergence of high position resolution (∼10 μm) silicon detectors in recent times have highlighted the urgent need for the development of new automated optical scanners of micron level resolution suited for characterizing microscopic features of these detectors. More specifically, for the newly developed silicon photo-multipliers (SiPM) that are compact, possessing excellent photon detection efficiency with gain comparable to photo-multiplier tube. In a short time, since their invention the SiPMs are already being widely used in several high-energy physics and astrophysics experiments as the photon readout element. The SiPM is a high quantum efficiency, multi-pixel photon counting detector with fastmore » timing and high gain. The presence of a wide variety of photo sensitive silicon detectors with high spatial resolution requires their performance evaluation to be carried out by photon beams of very compact spot size. We have designed a high resolution optical scanner that provides a monochromatic focused beam on a target plane. The transverse size of the beam was measured by the knife-edge method to be 1.7 μm at 1 − σ level. Since the beam size was an order of magnitude smaller than the typical feature size of silicon detectors, this optical scanner can be used for selective excitation of these detectors. The design and operational details of the optical scanner, high precision programmed movement of target plane (0.1 μm) integrated with general purpose data acquisition system developed for recording static and transient response photo sensitive silicon detector are reported in this paper. Entire functionality of scanner is validated by using it for selective excitation of individual pixels in a SiPM and identifying response of active and dead regions within SiPM. Results from these studies are presented in this paper.« less

Longitudinal Plasmoid in High-Speed Vortex Gas Flow Created by Capacity HF Discharge

DTIC Science & Technology

2010-10-28

interferometer with high space resolution, PIV method, FTIR spectrometer, optical spectrometer, pressure sensors with high time resolution, IR pyrometer and...of strong LP-vortex interaction. Intensive acoustic waves are created by CHFD in swirl flow in this regime. 38. Study of control of a longitudinal...quartz tube, 4- HF ball electrode, 5- Tesla’s transformer, 6- microwave interferometer, 7- video camera, 8-optical pyrometer , 9-pressure sensor, 10

Circuit for high resolution decoding of multi-anode microchannel array detectors

NASA Technical Reports Server (NTRS)

Kasle, David B. (Inventor)

1995-01-01

A circuit for high resolution decoding of multi-anode microchannel array detectors consisting of input registers accepting transient inputs from the anode array; anode encoding logic circuits connected to the input registers; midpoint pipeline registers connected to the anode encoding logic circuits; and pixel decoding logic circuits connected to the midpoint pipeline registers is described. A high resolution algorithm circuit operates in parallel with the pixel decoding logic circuit and computes a high resolution least significant bit to enhance the multianode microchannel array detector's spatial resolution by halving the pixel size and doubling the number of pixels in each axis of the anode array. A multiplexer is connected to the pixel decoding logic circuit and allows a user selectable pixel address output according to the actual multi-anode microchannel array detector anode array size. An output register concatenates the high resolution least significant bit onto the standard ten bit pixel address location to provide an eleven bit pixel address, and also stores the full eleven bit pixel address. A timing and control state machine is connected to the input registers, the anode encoding logic circuits, and the output register for managing the overall operation of the circuit.

Xenon detector with high energy resolution for gamma-ray line emission registration

NASA Astrophysics Data System (ADS)

Novikov, Alexander S.; Ulin, Sergey E.; Chernysheva, Irina V.; Dmitrenko, Valery V.; Grachev, Victor M.; Petrenko, Denis V.; Shustov, Alexander E.; Uteshev, Ziyaetdin M.; Vlasik, Konstantin F.

2014-09-01

A description of the xenon detector (XD) for gamma-ray line emission registration is presented. The detector provides high energy resolution and is able to operate under extreme environmental conditions (wide temperature range and unfavorable acoustic action). Resistance to acoustic noise as well as improvement in energy resolution has been achieved by means of real-time digital pulse processing. Another important XD feature is the ionization chamber's thin wall with composite housing, which significantly decreases the mass of the device and expands its energy range, especially at low energies.

Impaired temporal, not just spatial, resolution in amblyopia.

PubMed

Spang, Karoline; Fahle, Manfred

2009-11-01

In amblyopia, neuronal deficits deteriorate spatial vision including visual acuity, possibly because of a lack of use-dependent fine-tuning of afferents to the visual cortex during infancy; but temporal processing may deteriorate as well. Temporal, rather than spatial, resolution was investigated in patients with amblyopia by means of a task based on time-defined figure-ground segregation. Patients had to indicate the quadrant of the visual field where a purely time-defined square appeared. The results showed a clear decrease in temporal resolution of patients' amblyopic eyes compared with the dominant eyes in this task. The extent of this decrease in figure-ground segregation based on time of motion onset only loosely correlated with the decrease in spatial resolution and spanned a smaller range than did the spatial loss. Control experiments with artificially induced blur in normal observers confirmed that the decrease in temporal resolution was not simply due to the acuity loss. Amblyopia not only decreases spatial resolution, but also temporal factors such as time-based figure-ground segregation, even at high stimulus contrasts. This finding suggests that the realm of neuronal processes that may be disturbed in amblyopia is larger than originally thought.

Evaluation of registration accuracy between Sentinel-2 and Landsat 8

NASA Astrophysics Data System (ADS)

Barazzetti, Luigi; Cuca, Branka; Previtali, Mattia

2016-08-01

Starting from June 2015, Sentinel-2A is delivering high resolution optical images (ground resolution up to 10 meters) to provide a global coverage of the Earth's land surface every 10 days. The planned launch of Sentinel-2B along with the integration of Landsat images will provide time series with an unprecedented revisit time indispensable for numerous monitoring applications, in which high resolution multi-temporal information is required. They include agriculture, water bodies, natural hazards to name a few. However, the combined use of multi-temporal images requires an accurate geometric registration, i.e. pixel-to-pixel correspondence for terrain-corrected products. This paper presents an analysis of spatial co-registration accuracy for several datasets of Sentinel-2 and Landsat 8 images distributed all around the world. Images were compared with digital correlation techniques for image matching, obtaining an evaluation of registration accuracy with an affine transformation as geometrical model. Results demonstrate that sub-pixel accuracy was achieved between 10 m resolution Sentinel-2 bands (band 3) and 15 m resolution panchromatic Landsat images (band 8).

Testing the limits of Paleozoic chronostratigraphic correlation via high-resolution (13Ccarb) biochemostratigraphy across the Llandovery–Wenlock (Silurian) boundary: Is a unified Phanerozoic time scale achievable?

USGS Publications Warehouse

Cramer, Bradley D.; Loydell, David K.; Samtleben, Christian; Munnecke, Axel; Kaljo, Dimitri; Mannik, Peep; Martma, Tonu; Jeppsson, Lennart; Kleffner, Mark A.; Barrick, James E.; Johnson, Craig A.; Emsbo, Poul; Joachimski, Michael M.; Bickert, Torsten; Saltzman, Matthew R.

2010-01-01

The resolution and fidelity of global chronostratigraphic correlation are direct functions of the time period under consideration. By virtue of deep-ocean cores and astrochronology, the Cenozoic and Mesozoic time scales carry error bars of a few thousand years (k.y.) to a few hundred k.y. In contrast, most of the Paleozoic time scale carries error bars of plus or minus a few million years (m.y.), and chronostratigraphic control better than ??1 m.y. is considered "high resolution." The general lack of Paleozoic abyssal sediments and paucity of orbitally tuned Paleozoic data series combined with the relative incompleteness of the Paleozoic stratigraphic record have proven historically to be such an obstacle to intercontinental chronostratigraphic correlation that resolving the Paleozoic time scale to the level achieved during the Mesozoic and Cenozoic was viewed as impractical, impossible, or both. Here, we utilize integrated graptolite, conodont, and carbonate carbon isotope (??13Ccarb) data from three paleocontinents (Baltica, Avalonia, and Laurentia) to demonstrate chronostratigraphic control for upper Llando very through middle Wenlock (Telychian-Sheinwoodian, ~436-426 Ma) strata with a resolution of a few hundred k.y. The interval surrounding the base of the Wenlock Series can now be correlated globally with precision approaching 100 k.y., but some intervals (e.g., uppermost Telychian and upper Shein-woodian) are either yet to be studied in sufficient detail or do not show sufficient biologic speciation and/or extinction or carbon isotopic features to delineate such small time slices. Although producing such resolution during the Paleozoic presents an array of challenges unique to the era, we have begun to demonstrate that erecting a Paleozoic time scale comparable to that of younger eras is achievable. ?? 2010 Geological Society of America.

Submicron-resolution photoacoustic microscopy of endogenous light-absorbing biomolecules

NASA Astrophysics Data System (ADS)

Zhang, Chi

Photoacoustic imaging in biomedicine has the unique advantage of probing endogenous light absorbers at various length scales with a 100% relative sensitivity. Among the several modalities of photoacoustic imaging, optical-resolution photoacoustic microscopy (OR-PAM) can achieve high spatial resolution, on the order of optical wavelength, at <1 mm depth in biological tissue (the optical ballistic regime). OR-PAM has been applied successfully to structural and functional imaging of blood vasculature and red blood cells in vivo. Any molecules which absorb sufficient light at certain wavelengths can potentially be imaged by PAM. Compared with pure optical imaging, which typically targets fluorescent markers, label-free PAM avoids the major concerns that the fluorescent labeling probes may disturb the function of biomolecules and may have an insufficient density. This dissertation aims to advance label-free OR-PAM to the subcellular scale. The first part of this dissertation describes the technological advancement of PAM yielding high spatial resolution in 3D. The lateral resolution was improved by using optical objectives with high numerical apertures for optical focusing. The axial resolution was improved by using broadband ultrasonic transducers for ultrasound detection. We achieved 220 nm lateral resolution in transmission mode, 0.43 microm lateral resolution in reflection mode, 7.6 microm axial resolution in normal tissue, and 5.8 microm axial resolution with silicone oil immersion/injection. The achieved lateral resolution and axial resolution were the finest reported at the time. With high-resolution in 3D, PAM was demonstrated to resolve cellular and subcellular structures in vivo, such as red blood cells and melanosomes in melanoma cells. Compared with previous PAM systems, our high-resolution PAM could resolve capillaries in mouse ears more clearly. As an example application, we demonstrated intracellular temperature imaging, assisted by fluorescence signal detection, with sub-degree temperature resolution and sub-micron lateral resolution. The second part of this dissertation describes the exploration of endogenous light-absorbing biomolecules for PAM. We demonstrated cytochromes and myoglobin as new absorption contrasts for PAM and identified the corresponding optimal wavelengths for imaging. Fixed fibroblasts on slides and mouse ear sections were imaged by PAM at 422 nm and 250 nm wavelengths to reveal cytoplasms and nuclei, respectively, as confirmed by standard hematoxylin and eosin (H&E) histology. By imaging a blood-perfused mouse heart at 532 nm down to 150 microm in depth, we derived the myocardial sheet thickness and the cleavage height from an undehydrated heart for the first time. The findings promote PAM at new wavelengths and open up new possibilities for characterizing biological tissue. Of particular interest, dual-wavelength PAM around 250 nm and 420 nm wavelengths is analogous to H&E histology. The last part of this dissertation describes the development of sectioning photoacoustic microscopy (SPAM), based on the advancement in spatial resolution and new contrasts for PAM, with applications in brain histology. Label-free SPAM, assisted by a microtome, acquires serial distortion-free images of a specimen on the surface. By exciting cell nuclei at 266 nm wavelength with high resolution, SPAM could pinpoint cell nuclei sensitively and specifically in the mouse brain section, as confirmed by H&E histology. SPAM was demonstrated to generate high-resolution 3D images, highlighting cell nuclei, of formalin-fixed paraffin-embedded mouse brains without tissue staining or clearing. SPAM can potentially serve as a high-throughput and minimal-artifact substitute for histology, probe many other biomolecules and cells, and become a universal tool for animal or human whole-organ microscopy, with diverse applications in life sciences.

Monolithic echo-less photoconductive switches as a high-resolution detector for terahertz time-domain spectroscopy

NASA Astrophysics Data System (ADS)

Maussang, K.; Palomo, J.; Manceau, J.-M.; Colombelli, R.; Sagnes, I.; Li, L. H.; Linfield, E. H.; Davies, A. G.; Mangeney, J.; Tignon, J.; Dhillon, S. S.

2017-04-01

Interdigitated photoconductive (iPC) switches are powerful and convenient devices for time-resolved spectroscopy, with the ability to operate both as sources and detectors of terahertz (THz) frequency pulses. However, reflection of the emitted or detected radiation within the device substrate itself can lead to echoes that inherently limit the spectroscopic resolution achievable for their use in time-domain spectroscopy (TDS) systems. In this work, we demonstrate a design of low-temperature-grown-GaAs (LT-GaAs) iPC switches for THz pulse detection that suppresses such unwanted echoes. This is realized through the growth of a buried multilayer LT-GaAs structure that retains its ultrafast properties, which, after wafer bonding to a metal-coated host substrate, results in an iPC switch with a metal plane buried at a subwavelength depth below the LT-GaAs surface. Using this device as a detector, and coupling it to an echo-less iPC source, enables echo-free THz-TDS and high-resolution spectroscopy, with a resolution limited only by the temporal length of the measurement governed by the mechanical delay line used. As a proof-of-principle, the 212-221 and the 101-212 rotational lines of water vapor have been spectrally resolved, demonstrating a spectral resolution below 10 GHz.

First high-statistics and high-resolution recoil-ion data from the WITCH retardation spectrometer

NASA Astrophysics Data System (ADS)

Finlay, P.; Breitenfeldt, M.; Porobić, T.; Wursten, E.; Ban, G.; Beck, M.; Couratin, C.; Fabian, X.; Fléchard, X.; Friedag, P.; Glück, F.; Herlert, A.; Knecht, A.; Kozlov, V. Y.; Liénard, E.; Soti, G.; Tandecki, M.; Traykov, E.; Van Gorp, S.; Weinheimer, Ch.; Zákoucký, D.; Severijns, N.

2016-07-01

The first high-statistics and high-resolution data set for the integrated recoil-ion energy spectrum following the β^+ decay of 35Ar has been collected with the WITCH retardation spectrometer located at CERN-ISOLDE. Over 25 million recoil-ion events were recorded on a large-area multichannel plate (MCP) detector with a time-stamp precision of 2ns and position resolution of 0.1mm due to the newly upgraded data acquisition based on the LPC Caen FASTER protocol. The number of recoil ions was measured for more than 15 different settings of the retardation potential, complemented by dedicated background and half-life measurements. Previously unidentified systematic effects, including an energy-dependent efficiency of the main MCP and a radiation-induced time-dependent background, have been identified and incorporated into the analysis. However, further understanding and treatment of the radiation-induced background requires additional dedicated measurements and remains the current limiting factor in extracting a beta-neutrino angular correlation coefficient for 35Ar decay using the WITCH spectrometer.

A high-sensitivity search for extraterrestrial intelligence at lambda 18 cm

NASA Technical Reports Server (NTRS)

Tarter, J.; Cuzzi, J.; Black, D.; Clark, T.

1980-01-01

A targeted high-sensitivity search for narrow-band signals near a wavelength of 18 cm has been conducted using the 91-m radiotelescope of the National Radio Astronomy Observatory. The search included 201 nearby solar-type stars and achieved a frequency resolution of 5.5 Hz over a 1.4-MHz bandwidth. This high spectral resolution was obtained through a non-real-time reduction procedure using a Mark I VLBI recording terminal in conjunction with the CDC 7600 computational facility at the NASA-Ames Research Center. This is the first high-resolution search for narrow-band signals in this wavelength regime. To date it is the most sensitive search per unit observing time of any search strategy which does not postulate a unique magic frequency. Data show no evidence for narrow-band signals due to extraterrestrial intelligence at a 12-standard-deviation upper limit on signal strength of 1.1 x 10 to the -23rd W/sq m.

Urban-hazard risk analysis: mapping of heat-related risks in the elderly in major Italian cities.

PubMed

Morabito, Marco; Crisci, Alfonso; Gioli, Beniamino; Gualtieri, Giovanni; Toscano, Piero; Di Stefano, Valentina; Orlandini, Simone; Gensini, Gian Franco

2015-01-01

Short-term impacts of high temperatures on the elderly are well known. Even though Italy has the highest proportion of elderly citizens in Europe, there is a lack of information on spatial heat-related elderly risks. Development of high-resolution, heat-related urban risk maps regarding the elderly population (≥ 65). A long time-series (2001-2013) of remote sensing MODIS data, averaged over the summer period for eleven major Italian cities, were downscaled to obtain high spatial resolution (100 m) daytime and night-time land surface temperatures (LST). LST was estimated pixel-wise by applying two statistical model approaches: 1) the Linear Regression Model (LRM); 2) the Generalized Additive Model (GAM). Total and elderly population density data were extracted from the Joint Research Centre population grid (100 m) from the 2001 census (Eurostat source), and processed together using "Crichton's Risk Triangle" hazard-risk methodology for obtaining a Heat-related Elderly Risk Index (HERI). The GAM procedure allowed for improved daytime and night-time LST estimations compared to the LRM approach. High-resolution maps of daytime and night-time HERI levels were developed for inland and coastal cities. Urban areas with the hazardous HERI level (very high risk) were not necessarily characterized by the highest temperatures. The hazardous HERI level was generally localized to encompass the city-centre in inland cities and the inner area in coastal cities. The two most dangerous HERI levels were greater in the coastal rather than inland cities. This study shows the great potential of combining geospatial technologies and spatial demographic characteristics within a simple and flexible framework in order to provide high-resolution urban mapping of daytime and night-time HERI. In this way, potential areas for intervention are immediately identified with up-to-street level details. This information could support public health operators and facilitate coordination for heat-related emergencies.

Urban-Hazard Risk Analysis: Mapping of Heat-Related Risks in the Elderly in Major Italian Cities

PubMed Central

Morabito, Marco; Crisci, Alfonso; Gioli, Beniamino; Gualtieri, Giovanni; Toscano, Piero; Di Stefano, Valentina; Orlandini, Simone; Gensini, Gian Franco

2015-01-01

Background Short-term impacts of high temperatures on the elderly are well known. Even though Italy has the highest proportion of elderly citizens in Europe, there is a lack of information on spatial heat-related elderly risks. Objectives Development of high-resolution, heat-related urban risk maps regarding the elderly population (≥65). Methods A long time-series (2001–2013) of remote sensing MODIS data, averaged over the summer period for eleven major Italian cities, were downscaled to obtain high spatial resolution (100 m) daytime and night-time land surface temperatures (LST). LST was estimated pixel-wise by applying two statistical model approaches: 1) the Linear Regression Model (LRM); 2) the Generalized Additive Model (GAM). Total and elderly population density data were extracted from the Joint Research Centre population grid (100 m) from the 2001 census (Eurostat source), and processed together using “Crichton’s Risk Triangle” hazard-risk methodology for obtaining a Heat-related Elderly Risk Index (HERI). Results The GAM procedure allowed for improved daytime and night-time LST estimations compared to the LRM approach. High-resolution maps of daytime and night-time HERI levels were developed for inland and coastal cities. Urban areas with the hazardous HERI level (very high risk) were not necessarily characterized by the highest temperatures. The hazardous HERI level was generally localized to encompass the city-centre in inland cities and the inner area in coastal cities. The two most dangerous HERI levels were greater in the coastal rather than inland cities. Conclusions This study shows the great potential of combining geospatial technologies and spatial demographic characteristics within a simple and flexible framework in order to provide high-resolution urban mapping of daytime and night-time HERI. In this way, potential areas for intervention are immediately identified with up-to-street level details. This information could support public health operators and facilitate coordination for heat-related emergencies. PMID:25985204

SMART-X: Square Meter, Arcsecond Resolution Telescope for X-rays

NASA Astrophysics Data System (ADS)

Vikhlinin, Alexey; SMART-X Collaboration

2013-04-01

SMART-X is a concept for a next-generation X-ray observatory with large-area, 0.5" angular resolution grazing incidence adjustable X-ray mirrors, high-throughput critical angle transmission gratings, and X-ray microcalorimeter and CMOS-based imager in the focal plane. High angular resolution is enabled by new technology based on controlling the shape of mirror segments using thin film piezo actuators deposited on the back surface. Science applications include observations of growth of supermassive black holes since redshifts of ~10, ultra-deep surveys over 10's of square degrees, galaxy assembly at z=2-3, as well as new opportunities in the high-resolution X-ray spectroscopy and time domains. We also review the progress in technology development, tests, and mission design over the past year.

Investigation of image distortion due to MCP electronic readout misalignment and correction via customized GUI application

NASA Astrophysics Data System (ADS)

Vitucci, G.; Minniti, T.; Tremsin, A. S.; Kockelmann, W.; Gorini, G.

2018-04-01

The MCP-based neutron counting detector is a novel device that allows high spatial resolution and time-resolved neutron radiography and tomography with epithermal, thermal and cold neutrons. Time resolution is possible by the high readout speeds of ~ 1200 frames/sec, allowing high resolution event counting with relatively high rates without spatial resolution degradation due to event overlaps. The electronic readout is based on a Timepix sensor, a CMOS pixel readout chip developed at CERN. Currently, a geometry of a quad Timepix detector is used with an active format of 28 × 28 mm2 limited by the size of the Timepix quad (2 × 2 chips) readout. Measurements of a set of high-precision micrometers test samples have been performed at the Imaging and Materials Science & Engineering (IMAT) beamline operating at the ISIS spallation neutron source (U.K.). The aim of these experiments was the full characterization of the chip misalignment and of the gaps between each pad in the quad Timepix sensor. Such misalignment causes distortions of the recorded shape of the sample analyzed. We present in this work a post-processing image procedure that considers and corrects these effects. Results of the correction will be discussed and the efficacy of this method evaluated.

Operation Sun Beam, Shot Small Boy. Project Officer's report - Project 7. 10. Spectral analysis with high-time resolution of the thermal-radiation pulse

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mahoney, J.J.; Harris, L.H.; Hennecke, H.J.

1985-09-01

The primary objective of this project was to investigate the spectral irradiance and luminosity versus time for the first thermal pulse at Shot Small Boy. This was accomplished by use of spectral filters with narrow band passes, phototubes, and magnetic tape recorders with high time resolution at two locations. The measured elapsed time to the first thermal maximum was from 50 to 110 microseconds, depending on wavelength. A graph of radiant thermal power versus time was obtained for the thermal pulse. The delineation of the first thermal pulse, especially the rise portion, is considered to be more definite than hasmore » been obtained previously. The resolution time of the instrumentation was approximately 50 microseconds. Secondary objectives were to measure the total luminosity versus time and also to measure the atmospheric attenuation. These objectives were accomplished by making measurements at two distances, 2.5 and 3.5 miles, from ground zero. In the case of the total luminosity measurements, a system of filters with a spectral transmittance approximating the sensitivity response of the average human eye was used. The results are tabulated in the report.« less

Statistical Examination of the Resolution of a Block-Scale Urban Drainage Model

NASA Astrophysics Data System (ADS)

Goldstein, A.; Montalto, F. A.; Digiovanni, K. A.

2009-12-01

Stormwater drainage models are utilized by cities in order to plan retention systems to prevent combined sewage overflows and design for development. These models aggregate subcatchments and ignore small pipelines providing a coarse representation of a sewage network. This study evaluates the importance of resolution by comparing two models developed on a neighborhood scale for predicting the total quantity and peak flow of runoff to observed runoff measured at the site. The low and high resolution models were designed for a 2.6 ha block in Bronx, NYC in EPA Stormwater Management Model (SWMM) using a single catchment and separate subcatchments based on surface cover, respectively. The surface covers represented included sidewalks, street, buildings, and backyards. Characteristics for physical surfaces and the infrastructure in the high resolution mode were determined from site visits, sewer pipe maps, aerial photographs, and GIS data-sets provided by the NYC Department of City Planning. Since the low resolution model was depicted at a coarser scale, generalizations were assumed about the overall average characteristics of the catchment. Rainfall and runoff data were monitored over a four month period during the summer rainy season. A total of 53 rain fall events were recorded but only 29 storms produced significant amount of runoffs to be evaluated in the simulations. To determine which model was more accurate at predicting the observed runoff, three characteristics for each storm were compared: peak runoff, total runoff, and time to peak. Two statistical tests were used to determine the significance of the results: the percent difference for each storm and the overall Chi-squared Goodness of Fit distribution for both the low and high resolution model. These tests will evaluate if there is a statistical difference depending on the resolution of scale of the stormwater model. The scale of representation is being evaluated because it could have a profound impact on how low-impact development strategies are assessed. Rerouting flows to delay the time of entry into the combined sewage is the primary goal of stormwater source controls which may be better differentiated in a high resolution as opposed to low resolution model. The preliminary hypothesis is that the low resolution model simplifies watershed by defining attributes uniformly across the watershed. In the high resolution model, the physical flow can be more accurate depicted by connected the various subcatchments. For example, the runoff from buildings can directly be routed to the backyard. The main drawback to the high resolution model is the risk of adding uncertainty due to the number of parameters.

Quantitative measurement of zinc secretion from pancreatic islets with high temporal resolution using droplet-based microfluidics.

PubMed

Easley, Christopher J; Rocheleau, Jonathan V; Head, W Steven; Piston, David W

2009-11-01

We assayed glucose-stimulated insulin secretion (GSIS) from live, murine islets of Langerhans in microfluidic devices by the downstream formation of aqueous droplets. Zinc ions, which are cosecreted with insulin from beta-cells, were quantitatively measured from single islets with high temporal resolution using a fluorescent indicator, FluoZin-3. Real-time storage of secretions into droplets (volume of 0.470 +/- 0.009 nL) effectively preserves the temporal chemical information, allowing reconstruction of the secretory time record. The use of passive flow control within the device removes the need for syringe pumps, requiring only a single hand-held syringe. Under stimulatory glucose levels (11 mM), bursts of zinc as high as approximately 800 fg islet(-1) min(-1) were measured. Treatment with diazoxide effectively blocked zinc secretion, as expected. High temporal resolution reveals two major classes of oscillations in secreted zinc, with predominate periods at approximately 20-40 s and approximately 5-10 min. The more rapid oscillation periods match closely with those of intraislet calcium oscillations, while the slower oscillations are consistent with insulin pulses typically measured in bulk islet experiments or in the bloodstream. This droplet sampling technique should be widely applicable to time-resolved cellular secretion measurements, either in real-time or for postprocessing.

Quantitative measurement of zinc secretion from pancreatic islets with high temporal resolution using droplet-based microfluidics

PubMed Central

Easley, Christopher J.; Rocheleau, Jonathan V.; Head, W. Steven; Piston, David W.

2009-01-01

We assayed glucose-stimulated insulin secretion (GSIS) from live, murine islets of Langerhans in microfluidic devices by the downstream formation of aqueous droplets. Zinc ions, which are co-secreted with insulin from β-cells, were quantitatively measured from single islets with high temporal resolution using a fluorescent indicator, FluoZin-3. Real-time storage of secretions into droplets (volume of 0.470 ± 0.009 nL) effectively preserves the temporal chemical information, allowing reconstruction of the secretory time record. The use of passive flow control within the device removes the need for syringe pumps, requiring only a single handheld syringe. Under stimulatory glucose levels (11 mM), bursts of zinc as high as ~800 fg islet−1 min−1 were measured. Treatment with diazoxide effectively blocked zinc secretion, as expected. High temporal resolution reveals two major classes of oscillations in secreted zinc, with predominate periods at ~20-40 s and ~ 5-10 min. The more rapid oscillation periods match closely with those of intraislet calcium oscillations, while the slower oscillations are consistent with insulin pulses typically measured in bulk islet experiments or in the bloodstream. This droplet sampling technique should be widely applicable to time-resolved cellular secretion measurements, either in real-time or for post-processing. PMID:19874061

An efficient photogrammetric stereo matching method for high-resolution images

NASA Astrophysics Data System (ADS)

Li, Yingsong; Zheng, Shunyi; Wang, Xiaonan; Ma, Hao

2016-12-01

Stereo matching of high-resolution images is a great challenge in photogrammetry. The main difficulty is the enormous processing workload that involves substantial computing time and memory consumption. In recent years, the semi-global matching (SGM) method has been a promising approach for solving stereo problems in different data sets. However, the time complexity and memory demand of SGM are proportional to the scale of the images involved, which leads to very high consumption when dealing with large images. To solve it, this paper presents an efficient hierarchical matching strategy based on the SGM algorithm using single instruction multiple data instructions and structured parallelism in the central processing unit. The proposed method can significantly reduce the computational time and memory required for large scale stereo matching. The three-dimensional (3D) surface is reconstructed by triangulating and fusing redundant reconstruction information from multi-view matching results. Finally, three high-resolution aerial date sets are used to evaluate our improvement. Furthermore, precise airborne laser scanner data of one data set is used to measure the accuracy of our reconstruction. Experimental results demonstrate that our method remarkably outperforms in terms of time and memory savings while maintaining the density and precision of the 3D cloud points derived.

The investigation of Martian dune fields using very high resolution photogrammetric measurements and time series analysis

NASA Astrophysics Data System (ADS)

Kim, J.; Park, M.; Baik, H. S.; Choi, Y.

2016-12-01

At the present time, arguments continue regarding the migration speeds of Martian dune fields and their correlation with atmospheric circulation. However, precisely measuring the spatial translation of Martian dunes has rarely conducted only a very few times Therefore, we developed a generic procedure to precisely measure the migration of dune fields with recently introduced 25-cm resolution High Resolution Imaging Science Experimen (HIRISE) employing a high-accuracy photogrammetric processor and sub-pixel image correlator. The processor was designed to trace estimated dune migration, albeit slight, over the Martian surface by 1) the introduction of very high resolution ortho images and stereo analysis based on hierarchical geodetic control for better initial point settings; 2) positioning error removal throughout the sensor model refinement with a non-rigorous bundle block adjustment, which makes possible the co-alignment of all images in a time series; and 3) improved sub-pixel co-registration algorithms using optical flow with a refinement stage conducted on a pyramidal grid processor and a blunder classifier. Moreover, volumetric changes of Martian dunes were additionally traced by means of stereo analysis and photoclinometry. The established algorithms have been tested using high-resolution HIRISE images over a large number of Martian dune fields covering whole Mars Global Dune Database. Migrations over well-known crater dune fields appeared to be almost static for the considerable temporal periods and were weakly correlated with wind directions estimated by the Mars Climate Database (Millour et al. 2015). Only over a few Martian dune fields, such as Kaiser crater, meaningful migration speeds (>1m/year) compared to phtotogrammetric error residual have been measured. Currently a technical improved processor to compensate error residual using time series observation is under developing and expected to produce the long term migration speed over Martian dune fields where constant HIRISE image acquisitions are available. ACKNOWLEDGEMENTS: The research leading to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007-2013) under iMars grant agreement Nr. 607379.

Phonon spectroscopy with sub-meV resolution by femtosecond x-ray diffuse scattering

DOE PAGES

Zhu, Diling; Robert, Aymeric; Henighan, Tom; ...

2015-08-10

We present a reconstruction of the transverse acoustic phonon dispersion of germanium from femtosecond time-resolved x-ray diffuse scattering measurements at the Linac Coherent Light Source. We demonstrate an energy resolution of 0.3 meV with a momentum resolution of 0.01 nm -1 using 10-keV x rays with a bandwidth of ~ 1 eV. This high resolution was achieved simultaneously for a large section of reciprocal space including regions closely following three of the principal symmetry directions. The phonon dispersion was reconstructed with less than 3 h of measurement time, during which neither the x-ray energy, the sample orientation, nor the detectormore » position were scanned. In conclusion, these results demonstrate how time-domain measurements can complement conventional frequency domain inelastic-scattering techniques.« less

Using High Spatial Resolution to Improve BOLD fMRI Detection at 3T

PubMed Central

Claise, Béatrice; Jean, Betty

2015-01-01

For different functional magnetic resonance imaging experiments using blood oxygenation level-dependent (BOLD) contrast, the acquisition of T 2*-weighted scans at a high spatial resolution may be advantageous in terms of time-course signal-to-noise ratio and of BOLD sensitivity when the regions are prone to susceptibility artifacts. In this study, we explore this solution by examining how spatial resolution influences activations elicited when appetizing food pictures are viewed. Twenty subjects were imaged at 3 T with two different voxel volumes, 3.4 μl and 27 μl. Despite the diminution of brain coverage, we found that high-resolution acquisition led to a better detection of activations. Though known to suffer to different degrees from susceptibility artifacts, the activations detected by high spatial resolution were notably consistent with those reported in published activation likelihood estimation meta-analyses, corresponding to taste-responsive regions. Furthermore, these regions were found activated bilaterally, in contrast with previous findings. Both the reduction of partial volume effect, which improves BOLD contrast, and the mitigation of susceptibility artifact, which boosts the signal to noise ratio in certain regions, explained the better detection noted with high resolution. The present study provides further evidences that high spatial resolution is a valuable solution for human BOLD fMRI, especially for studying food-related stimuli. PMID:26550990

Magnetic resonance imaging with an optical atomic magnetometer

PubMed Central

Xu, Shoujun; Yashchuk, Valeriy V.; Donaldson, Marcus H.; Rochester, Simon M.; Budker, Dmitry; Pines, Alexander

2006-01-01

We report an approach for the detection of magnetic resonance imaging without superconducting magnets and cryogenics: optical atomic magnetometry. This technique possesses a high sensitivity independent of the strength of the static magnetic field, extending the applicability of magnetic resonance imaging to low magnetic fields and eliminating imaging artifacts associated with high fields. By coupling with a remote-detection scheme, thereby improving the filling factor of the sample, we obtained time-resolved flow images of water with a temporal resolution of 0.1 s and spatial resolutions of 1.6 mm perpendicular to the flow and 4.5 mm along the flow. Potentially inexpensive, compact, and mobile, our technique provides a viable alternative for MRI detection with substantially enhanced sensitivity and time resolution for various situations where traditional MRI is not optimal. PMID:16885210

Space telescope scientific instruments

NASA Technical Reports Server (NTRS)

Leckrone, D. S.

1979-01-01

The paper describes the Space Telescope (ST) observatory, the design concepts of the five scientific instruments which will conduct the initial observatory observations, and summarizes their astronomical capabilities. The instruments are the wide-field and planetary camera (WFPC) which will receive the highest quality images, the faint-object camera (FOC) which will penetrate to the faintest limiting magnitudes and achieve the finest angular resolution possible, and the faint-object spectrograph (FOS), which will perform photon noise-limited spectroscopy and spectropolarimetry on objects substantially fainter than those accessible to ground-based spectrographs. In addition, the high resolution spectrograph (HRS) will provide higher spectral resolution with greater photometric accuracy than previously possible in ultraviolet astronomical spectroscopy, and the high-speed photometer will achieve precise time-resolved photometric observations of rapidly varying astronomical sources on short time scales.

TDC-based readout electronics for real-time acquisition of high resolution PET bio-images

NASA Astrophysics Data System (ADS)

Marino, N.; Saponara, S.; Ambrosi, G.; Baronti, F.; Bisogni, M. G.; Cerello, P.,; Ciciriello, F.; Corsi, F.; Fanucci, L.; Ionica, M.; Licciulli, F.; Marzocca, C.; Morrocchi, M.; Pennazio, F.; Roncella, R.; Santoni, C.; Wheadon, R.; Del Guerra, A.

2013-02-01

Positron emission tomography (PET) is a clinical and research tool for in vivo metabolic imaging. The demand for better image quality entails continuous research to improve PET instrumentation. In clinical applications, PET image quality benefits from the time of flight (TOF) feature. Indeed, by measuring the photons arrival time on the detectors with a resolution less than 100 ps, the annihilation point can be estimated with centimeter resolution. This leads to better noise level, contrast and clarity of detail in the images either using analytical or iterative reconstruction algorithms. This work discusses a silicon photomultiplier (SiPM)-based magnetic-field compatible TOF-PET module with depth of interaction (DOI) correction. The detector features a 3D architecture with two tiles of SiPMs coupled to a single LYSO scintillator on both its faces. The real-time front-end electronics is based on a current-mode ASIC where a low input impedance, fast current buffer allows achieving the required time resolution. A pipelined time to digital converter (TDC) measures and digitizes the arrival time and the energy of the events with a timestamp of 100 ps and 400 ps, respectively. An FPGA clusters the data and evaluates the DOI, with a simulated z resolution of the PET image of 1.4 mm FWHM.

Quantifying human-environment interactions using videography in the context of infectious disease transmission.

PubMed

Julian, Timothy R; Bustos, Carla; Kwong, Laura H; Badilla, Alejandro D; Lee, Julia; Bischel, Heather N; Canales, Robert A

2018-05-08

Quantitative data on human-environment interactions are needed to fully understand infectious disease transmission processes and conduct accurate risk assessments. Interaction events occur during an individual's movement through, and contact with, the environment, and can be quantified using diverse methodologies. Methods that utilize videography, coupled with specialized software, can provide a permanent record of events, collect detailed interactions in high resolution, be reviewed for accuracy, capture events difficult to observe in real-time, and gather multiple concurrent phenomena. In the accompanying video, the use of specialized software to capture humanenvironment interactions for human exposure and disease transmission is highlighted. Use of videography, combined with specialized software, allows for the collection of accurate quantitative representations of human-environment interactions in high resolution. Two specialized programs include the Virtual Timing Device for the Personal Computer, which collects sequential microlevel activity time series of contact events and interactions, and LiveTrak, which is optimized to facilitate annotation of events in real-time. Opportunities to annotate behaviors at high resolution using these tools are promising, permitting detailed records that can be summarized to gain information on infectious disease transmission and incorporated into more complex models of human exposure and risk.

Real-time haptic cutting of high-resolution soft tissues.

PubMed

Wu, Jun; Westermann, Rüdiger; Dick, Christian

2014-01-01

We present our systematic efforts in advancing the computational performance of physically accurate soft tissue cutting simulation, which is at the core of surgery simulators in general. We demonstrate a real-time performance of 15 simulation frames per second for haptic soft tissue cutting of a deformable body at an effective resolution of 170,000 finite elements. This is achieved by the following innovative components: (1) a linked octree discretization of the deformable body, which allows for fast and robust topological modifications of the simulation domain, (2) a composite finite element formulation, which thoroughly reduces the number of simulation degrees of freedom and thus enables to carefully balance simulation performance and accuracy, (3) a highly efficient geometric multigrid solver for solving the linear systems of equations arising from implicit time integration, (4) an efficient collision detection algorithm that effectively exploits the composition structure, and (5) a stable haptic rendering algorithm for computing the feedback forces. Considering that our method increases the finite element resolution for physically accurate real-time soft tissue cutting simulation by an order of magnitude, our technique has a high potential to significantly advance the realism of surgery simulators.

Impact of resolution on aerosol radiative feedbacks with in online-coupled chemistry/climate simulations (WRF-Chem) for EURO-CORDEX compliant domains

NASA Astrophysics Data System (ADS)

López-Romero, Jose Maria; Baró, Rocío; Palacios-Peña, Laura; Jerez, Sonia; Jiménez-Guerrero, Pedro; Montávez, Juan Pedro

2016-04-01

Several studies have shown that a high spatial resolution in atmospheric model runs improves the simulation of some meteorological variables, such as precipitation, particularly extreme events and in regions with complex orography [1]. However, increasing model spatial resolution makes the computational time rise exponentially. Hence, very high resolution experiments on large domains can hamper the execution of climatic runs. This problem shoots up when using online-coupled chemistry climate models, making a careful evaluation of improvements versus costs mandatory. Under this umbrella, the objective of this work is to investigate the sensitivity of aerosol radiative feedbacks from online-coupled chemistry regional model simulations to the spatial resolution. For that, the WRF-Chem [2] model is used for a case study to simulate the episode occurring between July 25th and August 15th of 2010. It is characterized by a high loading of atmospheric aerosol particles coming mainly from wildfires over large European regions (Russia, Iberian Peninsula). Three spatial resolutions are used defined for Euro-Cordex compliant domains [3]: 0.44°, 0.22° and 0.11°. Anthropogenic emissions come from TNO databases [4]. The analysis focuses on air quality variables (mainly PM10, PM2.5), meteorological variables (temperature, radiation) and other aerosol optical properties (aerosol optical depth). The CPU time ratio for the different domains is 1 (0.44°), 4(0.22°) and 28(0.11°) (normalized times). Comparison among simulations and observations are analyzed. Preliminary results show the difficulty to justify the much larger computational cost of high-resolution experiments when comparing with observations from a meteorological point of view, despite the finer spatio-temporal detail of the obtained pollutant fields. [1] Prein, A. F. (2014, December). Precipitation in the EURO-CORDEX 0.11° and 0.44° simulations: high resolution, high benefits?. In AGU Fall Meeting Abstracts (Vol. 1, p. 3893). [2] Grell, G. A., Peckham, S. E., Schmitz, R., McKeen, S. A., Frost, G., Skamarock, W. C., & Eder, B. (2005). Fully coupled "online" chemistry within the WRF model. Atmospheric Environment, 39(37), 6957-6975. [3] Jacob, D., Petersen, J., Eggert, B., Alias, A., Christensen, O. B., Bouwer, L. M., ... & Georgopoulou, E. (2014). EURO-CORDEX: new high-resolution climate change projections for European impact research. Regional Environmental Change, 14(2), 563-578. [4] Pouliot, G., Denier van der Gon, H., Kuenen, J., Makar, P., Zhang, J., Moran, M., 2015. Analysis of the emission inventories and model-ready emission datasets of Europe and North America for phase 2 of the AQMEII project. Atmos. Environ. 115, 345-360.

First Optical Observations of Interhemispheric Electron Reflections Within Pulsating Aurora

NASA Technical Reports Server (NTRS)

Samara, M.; Michell, R. G.; Khazanov, G. V.

2017-01-01

A case study of a pulsating auroral event imaged optically at high time resolution presents direct observational evidence in agreement with the interhemispheric electron bouncing predicted by the Super Thermal Electron Transport model. Pulsation-on times are identified and subsequent equally spaced fainter pulsations are also noted and can be explained by a portion/percentage of the primary precipitating electrons reflecting upward from the ionosphere, traveling to the opposite hemisphere and reflecting upward again. The high time resolution of these data, combined with the short duration of the pulsation-on time (approx. 1 s) and the relatively long spacing between pulsations (approx. 6 to 9 s) made it possible to observe the faint optical pulses caused by the reflected electrons coming from the opposite hemisphere.

Fast 3D Surface Extraction 2 pages (including abstract)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sewell, Christopher Meyer; Patchett, John M.; Ahrens, James P.

Ocean scientists searching for isosurfaces and/or thresholds of interest in high resolution 3D datasets required a tedious and time-consuming interactive exploration experience. PISTON research and development activities are enabling ocean scientists to rapidly and interactively explore isosurfaces and thresholds in their large data sets using a simple slider with real time calculation and visualization of these features. Ocean Scientists can now visualize more features in less time, helping them gain a better understanding of the high resolution data sets they work with on a daily basis. Isosurface timings (512{sup 3} grid): VTK 7.7 s, Parallel VTK (48-core) 1.3 s, PISTONmore » OpenMP (48-core) 0.2 s, PISTON CUDA (Quadro 6000) 0.1 s.« less

Side readout of long scintillation crystal elements with digital SiPM for TOF-DOI PET.

PubMed

Yeom, Jung Yeol; Vinke, Ruud; Levin, Craig S

2014-12-01

Side readout of scintillation light from crystal elements in positron emission tomography (PET) is an alternative to conventional end-readout configurations, with the benefit of being able to provide accurate depth-of-interaction (DOI) information and good energy resolution while achieving excellent timing resolution required for time-of-flight PET. This paper explores different readout geometries of scintillation crystal elements with the goal of achieving a detector that simultaneously achieves excellent timing resolution, energy resolution, spatial resolution, and photon sensitivity. The performance of discrete LYSO scintillation elements of different lengths read out from the end/side with digital silicon photomultipliers (dSiPMs) has been assessed. Compared to 3 × 3 × 20 mm(3) LYSO crystals read out from their ends with a coincidence resolving time (CRT) of 162 ± 6 ps FWHM and saturated energy spectra, a side-readout configuration achieved an excellent CRT of 144 ± 2 ps FWHM after correcting for timing skews within the dSiPM and an energy resolution of 11.8% ± 0.2% without requiring energy saturation correction. Using a maximum likelihood estimation method on individual dSiPM pixel response that corresponds to different 511 keV photon interaction positions, the DOI resolution of this 3 × 3 × 20 mm(3) crystal side-readout configuration was computed to be 0.8 mm FWHM with negligible artifacts at the crystal ends. On the other hand, with smaller 3 × 3 × 5 mm(3) LYSO crystals that can also be tiled/stacked to provide DOI information, a timing resolution of 134 ± 6 ps was attained but produced highly saturated energy spectra. The energy, timing, and DOI resolution information extracted from the side of long scintillation crystal elements coupled to dSiPM have been acquired for the first time. The authors conclude in this proof of concept study that such detector configuration has the potential to enable outstanding detector performance in terms of timing, energy, and DOI resolution.

Side readout of long scintillation crystal elements with digital SiPM for TOF-DOI PET

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yeom, Jung Yeol, E-mail: yeomjy@kumoh.ac.kr, E-mail: cslevin@stanford.edu; Vinke, Ruud; Levin, Craig S., E-mail: yeomjy@kumoh.ac.kr, E-mail: cslevin@stanford.edu

Purpose: Side readout of scintillation light from crystal elements in positron emission tomography (PET) is an alternative to conventional end-readout configurations, with the benefit of being able to provide accurate depth-of-interaction (DOI) information and good energy resolution while achieving excellent timing resolution required for time-of-flight PET. This paper explores different readout geometries of scintillation crystal elements with the goal of achieving a detector that simultaneously achieves excellent timing resolution, energy resolution, spatial resolution, and photon sensitivity. Methods: The performance of discrete LYSO scintillation elements of different lengths read out from the end/side with digital silicon photomultipliers (dSiPMs) has been assessed.more » Results: Compared to 3 × 3 × 20 mm{sup 3} LYSO crystals read out from their ends with a coincidence resolving time (CRT) of 162 ± 6 ps FWHM and saturated energy spectra, a side-readout configuration achieved an excellent CRT of 144 ± 2 ps FWHM after correcting for timing skews within the dSiPM and an energy resolution of 11.8% ± 0.2% without requiring energy saturation correction. Using a maximum likelihood estimation method on individual dSiPM pixel response that corresponds to different 511 keV photon interaction positions, the DOI resolution of this 3 × 3 × 20 mm{sup 3} crystal side-readout configuration was computed to be 0.8 mm FWHM with negligible artifacts at the crystal ends. On the other hand, with smaller 3 × 3 × 5 mm{sup 3} LYSO crystals that can also be tiled/stacked to provide DOI information, a timing resolution of 134 ± 6 ps was attained but produced highly saturated energy spectra. Conclusions: The energy, timing, and DOI resolution information extracted from the side of long scintillation crystal elements coupled to dSiPM have been acquired for the first time. The authors conclude in this proof of concept study that such detector configuration has the potential to enable outstanding detector performance in terms of timing, energy, and DOI resolution.« less

Mapping paddy rice planting area in cold temperate climate region through analysis of time series Landsat 8 (OLI), Landsat 7 (ETM+) and MODIS imagery

NASA Astrophysics Data System (ADS)

Qin, Yuanwei; Xiao, Xiangming; Dong, Jinwei; Zhou, Yuting; Zhu, Zhe; Zhang, Geli; Du, Guoming; Jin, Cui; Kou, Weili; Wang, Jie; Li, Xiangping

2015-07-01

Accurate and timely rice paddy field maps with a fine spatial resolution would greatly improve our understanding of the effects of paddy rice agriculture on greenhouse gases emissions, food and water security, and human health. Rice paddy field maps were developed using optical images with high temporal resolution and coarse spatial resolution (e.g., Moderate Resolution Imaging Spectroradiometer (MODIS)) or low temporal resolution and high spatial resolution (e.g., Landsat TM/ETM+). In the past, the accuracy and efficiency for rice paddy field mapping at fine spatial resolutions were limited by the poor data availability and image-based algorithms. In this paper, time series MODIS and Landsat ETM+/OLI images, and the pixel- and phenology-based algorithm are used to map paddy rice planting area. The unique physical features of rice paddy fields during the flooding/open-canopy period are captured with the dynamics of vegetation indices, which are then used to identify rice paddy fields. The algorithm is tested in the Sanjiang Plain (path/row 114/27) in China in 2013. The overall accuracy of the resulted map of paddy rice planting area generated by both Landsat ETM+ and OLI is 97.3%, when evaluated with areas of interest (AOIs) derived from geo-referenced field photos. The paddy rice planting area map also agrees reasonably well with the official statistics at the level of state farms (R2 = 0.94). These results demonstrate that the combination of fine spatial resolution images and the phenology-based algorithm can provide a simple, robust, and automated approach to map the distribution of paddy rice agriculture in a year.

Design and performance evaluation of a high resolution IRI-microPET preclinical scanner

NASA Astrophysics Data System (ADS)

Islami rad, S. Z.; Peyvandi, R. Gholipour; lehdarboni, M. Askari; Ghafari, A. A.

2015-05-01

PET for small animal, IRI-microPET, was designed and built at the NSTRI. The scanner is made of four detectors positioned on a rotating gantry at a distance 50 mm from the center. Each detector consists of a 10×10 crystal matrix of 2×2×10 mm3 directly coupled to a PS-PMT. A position encoding circuit for specific PS-PMT has been designed, built and tested with a PD-MFS-2MS/s-8/14 data acquisition board. After implementing reconstruction algorithms (FBP, MLEM and SART) on sinograms, images quality and system performance were evaluated by energy resolution, timing resolution, spatial resolution, scatter fraction, sensitivity, RMS contrast and SNR parameters. The energy spectra were obtained for the crystals with an energy window of 300-700 keV. The energy resolution in 511 keV averaged over all modules, detectors, and crystals, was 23.5%. A timing resolution of 2.4 ns FWHM obtained by coincidence timing spectrum was measured with crystal LYSO. The radial and tangential resolutions for 18F (1.15-mm inner diameter) at the center of the field of view were 1.81 mm and 1.90 mm, respectively. At a radial offset of 5 mm, the FWHM values were 1.96 and 2.06 mm. The system scatter fraction was 7.1% for the mouse phantom. The sensitivity was measured for different energy windows, leading to a sensitivity of 1.74% at the center of FOV. Also, images quality was evaluated by RMS contrast and SNR factors, and the results show that the reconstructed images by MLEM algorithm have the best RMS contrast, and SNR. The IRI-microPET presents high image resolution, low scatter fraction values and improved SNR for animal studies.

Mapping paddy rice planting area in cold temperate climate region through analysis of time series Landsat 8 (OLI), Landsat 7 (ETM+) and MODIS imagery.

PubMed

Qin, Yuanwei; Xiao, Xiangming; Dong, Jinwei; Zhou, Yuting; Zhu, Zhe; Zhang, Geli; Du, Guoming; Jin, Cui; Kou, Weili; Wang, Jie; Li, Xiangping

2015-07-01

Accurate and timely rice paddy field maps with a fine spatial resolution would greatly improve our understanding of the effects of paddy rice agriculture on greenhouse gases emissions, food and water security, and human health. Rice paddy field maps were developed using optical images with high temporal resolution and coarse spatial resolution (e.g., Moderate Resolution Imaging Spectroradiometer (MODIS)) or low temporal resolution and high spatial resolution (e.g., Landsat TM/ETM+). In the past, the accuracy and efficiency for rice paddy field mapping at fine spatial resolutions were limited by the poor data availability and image-based algorithms. In this paper, time series MODIS and Landsat ETM+/OLI images, and the pixel- and phenology-based algorithm are used to map paddy rice planting area. The unique physical features of rice paddy fields during the flooding/open-canopy period are captured with the dynamics of vegetation indices, which are then used to identify rice paddy fields. The algorithm is tested in the Sanjiang Plain (path/row 114/27) in China in 2013. The overall accuracy of the resulted map of paddy rice planting area generated by both Landsat ETM+ and OLI is 97.3%, when evaluated with areas of interest (AOIs) derived from geo-referenced field photos. The paddy rice planting area map also agrees reasonably well with the official statistics at the level of state farms ( R 2 = 0.94). These results demonstrate that the combination of fine spatial resolution images and the phenology-based algorithm can provide a simple, robust, and automated approach to map the distribution of paddy rice agriculture in a year.

High-resolution spatiotemporal strain mapping reveals non-uniform deformation in micropatterned elastomers

NASA Astrophysics Data System (ADS)

Aksoy, B.; Rehman, A.; Bayraktar, H.; Alaca, B. E.

2017-04-01

Micropatterns are generated on a vast selection of polymeric substrates for various applications ranging from stretchable electronics to cellular mechanobiological systems. When these patterned substrates are exposed to external loading, strain field is primarily affected by the presence of microfabricated structures and similarly by fabrication-related defects. The capturing of such nonhomogeneous strain fields is of utmost importance in cases where study of the mechanical behavior with a high spatial resolution is necessary. Image-based non-contact strain measurement techniques are favorable and have recently been extended to scanning tunneling microscope and scanning electron microscope images for the characterization of mechanical properties of metallic materials, e.g. steel and aluminum, at the microscale. A similar real-time analysis of strain heterogeneity in elastomers is yet to be achieved during the entire loading sequence. The available measurement methods for polymeric materials mostly depend on cross-head displacement or precalibrated strain values. Thus, they suffer either from the lack of any real-time analysis, spatiotemporal distribution or high resolution in addition to a combination of these factors. In this work, these challenges are addressed by integrating a tensile stretcher with an inverted optical microscope and developing a subpixel particle tracking algorithm. As a proof of concept, the patterns with a critical dimension of 200 µm are generated on polydimethylsiloxane substrates and strain distribution in the vicinity of the patterns is captured with a high spatiotemporal resolution. In the field of strain measurement, there is always a tradeoff between minimum measurable strain value and spatial resolution. Current noncontact techniques on elastomers can deliver a strain resolution of 0.001% over a minimum length of 5 cm. More importantly, inhomogeneities within this quite large region cannot be captured. The proposed technique can overcome this challenge and provides a displacement measurement resolution of 116 nm and a strain resolution of 0.04% over a gage length of 300 µm. Similarly, the ability to capture inhomogeneities is demonstrated by mapping strain around a thru-hole. The robustness of the technique is also evaluated, where no appreciable change in strain measurement is observed despite the significant variations imposed on the measurement mesh. The proposed approach introduces critical improvements for the determination of displacement and strain gradients in elastomers regarding the real-time nature of strain mapping with a microscale spatial resolution.

Digital timing: sampling frequency, anti-aliasing filter and signal interpolation filter dependence on timing resolution.

PubMed

Cho, Sanghee; Grazioso, Ron; Zhang, Nan; Aykac, Mehmet; Schmand, Matthias

2011-12-07

The main focus of our study is to investigate how the performance of digital timing methods is affected by sampling rate, anti-aliasing and signal interpolation filters. We used the Nyquist sampling theorem to address some basic questions such as what will be the minimum sampling frequencies? How accurate will the signal interpolation be? How do we validate the timing measurements? The preferred sampling rate would be as low as possible, considering the high cost and power consumption of high-speed analog-to-digital converters. However, when the sampling rate is too low, due to the aliasing effect, some artifacts are produced in the timing resolution estimations; the shape of the timing profile is distorted and the FWHM values of the profile fluctuate as the source location changes. Anti-aliasing filters are required in this case to avoid the artifacts, but the timing is degraded as a result. When the sampling rate is marginally over the Nyquist rate, a proper signal interpolation is important. A sharp roll-off (higher order) filter is required to separate the baseband signal from its replicates to avoid the aliasing, but in return the computation will be higher. We demonstrated the analysis through a digital timing study using fast LSO scintillation crystals as used in time-of-flight PET scanners. From the study, we observed that there is no significant timing resolution degradation down to 1.3 Ghz sampling frequency, and the computation requirement for the signal interpolation is reasonably low. A so-called sliding test is proposed as a validation tool checking constant timing resolution behavior of a given timing pick-off method regardless of the source location change. Lastly, the performance comparison for several digital timing methods is also shown.

Random phase detection in multidimensional NMR.

PubMed

Maciejewski, Mark W; Fenwick, Matthew; Schuyler, Adam D; Stern, Alan S; Gorbatyuk, Vitaliy; Hoch, Jeffrey C

2011-10-04

Despite advances in resolution accompanying the development of high-field superconducting magnets, biomolecular applications of NMR require multiple dimensions in order to resolve individual resonances, and the achievable resolution is typically limited by practical constraints on measuring time. In addition to the need for measuring long evolution times to obtain high resolution, the need to distinguish the sign of the frequency constrains the ability to shorten measuring times. Sign discrimination is typically accomplished by sampling the signal with two different receiver phases or by selecting a reference frequency outside the range of frequencies spanned by the signal and then sampling at a higher rate. In the parametrically sampled (indirect) time dimensions of multidimensional NMR experiments, either method imposes an additional factor of 2 sampling burden for each dimension. We demonstrate that by using a single detector phase at each time sample point, but randomly altering the phase for different points, the sign ambiguity that attends fixed single-phase detection is resolved. Random phase detection enables a reduction in experiment time by a factor of 2 for each indirect dimension, amounting to a factor of 8 for a four-dimensional experiment, albeit at the cost of introducing sampling artifacts. Alternatively, for fixed measuring time, random phase detection can be used to double resolution in each indirect dimension. Random phase detection is complementary to nonuniform sampling methods, and their combination offers the potential for additional benefits. In addition to applications in biomolecular NMR, random phase detection could be useful in magnetic resonance imaging and other signal processing contexts.

On the timing performance of thin planar silicon sensors

NASA Astrophysics Data System (ADS)

Akchurin, N.; Ciriolo, V.; Currás, E.; Damgov, J.; Fernández, M.; Gallrapp, C.; Gray, L.; Junkes, A.; Mannelli, M.; Martin Kwok, K. H.; Meridiani, P.; Moll, M.; Nourbakhsh, S.; Pigazzini, S.; Scharf, C.; Silva, P.; Steinbrueck, G.; de Fatis, T. Tabarelli; Vila, I.

2017-07-01

We report on the signal timing capabilities of thin silicon sensors when traversed by multiple simultaneous minimum ionizing particles (MIP). Three different planar sensors, with depletion thicknesses 133, 211, and 285 μm, have been exposed to high energy muons and electrons at CERN. We describe signal shape and timing resolution measurements as well as the response of these devices as a function of the multiplicity of MIPs. We compare these measurements to simulations where possible. We achieve better than 20 ps timing resolution for signals larger than a few tens of MIPs.

Evacuee Compliance Behavior Analysis using High Resolution Demographic Information

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lu, Wei; Han, Lee; Liu, Cheng

2014-01-01

The purpose of this study is to examine whether evacuee compliance behavior with route assignments from different resolutions of demographic data would impact the evacuation performance. Most existing evacuation strategies assume that travelers will follow evacuation instructions, while in reality a certain percent of evacuees do not comply with prescribed instructions. In this paper, a comparison study of evacuation assignment based on Traffic Analysis Zones (TAZ) and high resolution LandScan USA Population Cells (LPC) were conducted for the detailed road network representing Alexandria, Virginia. A revised platform for evacuation modeling built on high resolution demographic data and activity-based microscopic trafficmore » simulation is proposed. The results indicate that evacuee compliance behavior affects evacuation efficiency with traditional TAZ assignment, but it does not significantly compromise the efficiency with high resolution LPC assignment. The TAZ assignment also underestimates the real travel time during evacuation, especially for high compliance simulations. This suggests that conventional evacuation studies based on TAZ assignment might not be effective at providing efficient guidance to evacuees. From the high resolution data perspective, traveler compliance behavior is an important factor but it does not impact the system performance significantly. The highlight of evacuee compliance behavior analysis should be emphasized on individual evacuee level route/shelter assignments, rather than the whole system performance.« less

Enhancement of Temporal Resolution and BOLD Sensitivity in Real-Time fMRI using Multi-Slab Echo-Volumar Imaging

PubMed Central

Posse, Stefan; Ackley, Elena; Mutihac, Radu; Rick, Jochen; Shane, Matthew; Murray-Krezan, Cristina; Zaitsev, Maxim; Speck, Oliver

2012-01-01

In this study, a new approach to high-speed fMRI using multi-slab echo-volumar imaging (EVI) is developed that minimizes geometrical image distortion and spatial blurring, and enables nonaliased sampling of physiological signal fluctuation to increase BOLD sensitivity compared to conventional echo-planar imaging (EPI). Real-time fMRI using whole brain 4-slab EVI with 286 ms temporal resolution (4 mm isotropic voxel size) and partial brain 2-slab EVI with 136 ms temporal resolution (4×4×6 mm3 voxel size) was performed on a clinical 3 Tesla MRI scanner equipped with 12-channel head coil. Four-slab EVI of visual and motor tasks significantly increased mean (visual: 96%, motor: 66%) and maximum t-score (visual: 263%, motor: 124%) and mean (visual: 59%, motor: 131%) and maximum (visual: 29%, motor: 67%) BOLD signal amplitude compared with EPI. Time domain moving average filtering (2 s width) to suppress physiological noise from cardiac and respiratory fluctuations further improved mean (visual: 196%, motor: 140%) and maximum (visual: 384%, motor: 200%) t-scores and increased extents of activation (visual: 73%, motor: 70%) compared to EPI. Similar sensitivity enhancement, which is attributed to high sampling rate at only moderately reduced temporal signal-to-noise ratio (mean: − 52%) and longer sampling of the BOLD effect in the echo-time domain compared to EPI, was measured in auditory cortex. Two-slab EVI further improved temporal resolution for measuring task-related activation and enabled mapping of five major resting state networks (RSNs) in individual subjects in 5 min scans. The bilateral sensorimotor, the default mode and the occipital RSNs were detectable in time frames as short as 75 s. In conclusion, the high sampling rate of real-time multi-slab EVI significantly improves sensitivity for studying the temporal dynamics of hemodynamic responses and for characterizing functional networks at high field strength in short measurement times. PMID:22398395

Fabrication and characterization of a 0.5-mm lutetium oxyorthosilicate detector array for high-resolution PET applications.

PubMed

Stickel, Jennifer R; Qi, Jinyi; Cherry, Simon R

2007-01-01

With the increasing use of in vivo imaging in mouse models of disease, there are many interesting applications that demand imaging of organs and tissues with submillimeter resolution. Though there are other contributing factors, the spatial resolution in small-animal PET is still largely determined by the detector pixel dimensions. In this work, a pair of lutetium oxyorthosilicate (LSO) arrays with 0.5-mm pixels was coupled to multichannel photomultiplier tubes and evaluated for use as high-resolution PET detectors. Flood histograms demonstrated that most crystals were clearly identifiable. Energy resolution varied from 22% to 38%. The coincidence timing resolution was 1.42-ns full width at half maximum (FWHM). The intrinsic spatial resolution was 0.68-mm FWHM as measured with a 30-gauge needle filled with (18)F. The improvement in spatial resolution in a tomographic setting is demonstrated using images of a line source phantom reconstructed with filtered backprojection and compared with images obtained from 2 dedicated small-animal PET scanners. Finally, a projection image of the mouse foot is shown to demonstrate the application of these 0.5-mm LSO detectors to a biologic task. A pair of highly pixelated LSO detections has been constructed and characterized for use as high-spatial-resolution PET detectors. It appears that small-animal PET systems capable of a FWHM spatial resolution of 600 microm or less are feasible and should be pursued.

Achieving subpixel resolution with time-correlated transient signals in pixelated CdZnTe gamma-ray sensors using a focused laser beam (Conference Presentation)

NASA Astrophysics Data System (ADS)

Ocampo Giraldo, Luis A.; Bolotnikov, Aleksey E.; Camarda, Giuseppe S.; Cui, Yonggang; De Geronimo, Gianluigi; Gul, Rubi; Fried, Jack; Hossain, Anwar; Unlu, Kenan; Vernon, Emerson; Yang, Ge; James, Ralph B.

2017-05-01

High-resolution position-sensitive detectors have been proposed to correct response non-uniformities in Cadmium Zinc Telluride (CZT) crystals by virtually subdividing the detectors area into small voxels and equalizing responses from each voxel. 3D pixelated detectors coupled with multichannel readout electronics are the most advanced type of CZT devices offering many options in signal processing and enhancing detector performance. One recent innovation proposed for pixelated detectors is to use the induced (transient) signals from neighboring pixels to achieve high sub-pixel position resolution while keeping large pixel sizes. The main hurdle in achieving this goal is the relatively low signal induced on the neighboring pixels because of the electrostatic shielding effect caused by the collecting pixel. In addition, to achieve high position sensitivity one should rely on time-correlated transient signals, which means that digitized output signals must be used. We present the results of our studies to measure the amplitude of the pixel signals so that these can be used to measure positions of the interaction points. This is done with the processing of digitized correlated time signals measured from several adjacent pixels taking into account rise-time and charge-sharing effects. In these measurements we used a focused pulsed laser to generate a 10-micron beam at one milliwatt (650-nm wavelength) over the detector surface while the collecting pixel was moved in cardinal directions. The results include measurements that present the benefits of combining conventional pixel geometry with digital pulse processing for the best approach in achieving sub-pixel position resolution with the pixel dimensions of approximately 2 mm. We also present the sub-pixel resolution measurements at comparable energies from various gamma emitting isotopes.

Basic performance evaluation of a Si-PM array-based LGSO phoswich DOI block detector for a high-resolution small animal PET system.

PubMed

Yamamoto, Seiichi

2013-07-01

The silicon photomultiplier (Si-PM) is a promising photodetector for PET. However, it remains unclear whether Si-PM can be used for a depth-of-interaction (DOI) detector based on the decay time differences of the scintillator where pulse shape analysis is used. For clarification, we tested the Hamamatsu 4 × 4 Si-PM array (S11065-025P) combined with scintillators that used different decay times to develop DOI block detectors using the pulse shape analysis. First, Ce-doped Gd(2)SiO(5) (GSO) scintillators of 0.5 mol% Ce were arranged in a 4 × 4 matrix and were optically coupled to the center of each pixel of the Si-PM array for measurement of the energy resolution as well as its gain variations according to the temperature. Then two types of Ce-doped Lu(1.9)Gd(0.1)Si0(5) (LGSO) scintillators, 0.025 mol% Ce (decay time: ~31 ns) and 0.75 mol% Ce (decay time: ~46 ns), were optically coupled in the DOI direction, arranged in a 11 × 7 matrix, and optically coupled to a Si-PM array for testing of the possibility of a high-resolution DOI detector. The energy resolution of the Si-PM array-based GSO block detector was 18 ± 4.4 % FWHM for a Cs-137 gamma source (662 keV). Less than 1 mm crystals were clearly resolved in the position map of the LGSO DOI block detector. The peak-to-valley ratio (P/V) derived from the pulse shape spectra of the LGSO DOI block detector was 2.2. These results confirmed that Si-PM array-based DOI block detectors are promising for high-resolution small animal PET systems.

Comprehensive blood plasma lipidomics by liquid chromatography/quadrupole time-of-flight mass spectrometry.

PubMed

Sandra, Koen; Pereira, Alberto Dos Santos; Vanhoenacker, Gerd; David, Frank; Sandra, Pat

2010-06-18

A lipidomics strategy, combining high resolution reversed-phase liquid chromatography (RPLC) with high resolution quadrupole time-of-flight mass spectrometry (QqTOF), is described. The method has carefully been assessed in both a qualitative and a quantitative fashion utilizing human blood plasma. The inherent low technical variability associated with the lipidomics method allows to measure 65% of the features with an intensity RSD value below 10%. Blood plasma lipid spike-in experiments demonstrate that relative concentration differences smaller than 25% can readily be revealed by means of a t-test. Utilizing an advanced identification strategy, it is shown that the detected features mainly originate from (lyso-)phospholipids, sphingolipids, mono-, di- and triacylglycerols and cholesterol esters. The high resolution offered by the up-front RPLC step further allows to discriminate various isomeric species associated with the different lipid classes. The added value of utilizing a Jetstream electrospray ionization (ESI) source over a regular ESI source in lipidomics is for the first time demonstrated. In addition, the application of ultra high performance LC (UHPLC) up to 1200bar to extend the peak capacity or increase productivity is discussed. Copyright (c) 2010 Elsevier B.V. All rights reserved.

Ultra high spatial and temporal resolution breast imaging at 7T.

PubMed

van de Bank, B L; Voogt, I J; Italiaander, M; Stehouwer, B L; Boer, V O; Luijten, P R; Klomp, D W J

2013-04-01

There is a need to obtain higher specificity in the detection of breast lesions using MRI. To address this need, Dynamic Contrast-Enhanced (DCE) MRI has been combined with other structural and functional MRI techniques. Unfortunately, owing to time constraints structural images at ultra-high spatial resolution can generally not be obtained during contrast uptake, whereas the relatively low spatial resolution of functional imaging (e.g. diffusion and perfusion) limits the detection of small lesions. To be able to increase spatial as well as temporal resolution simultaneously, the sensitivity of MR detection needs to increase as well as the ability to effectively accelerate the acquisition. The required gain in signal-to-noise ratio (SNR) can be obtained at 7T, whereas acceleration can be obtained with high-density receiver coil arrays. In this case, morphological imaging can be merged with DCE-MRI, and other functional techniques can be obtained at higher spatial resolution, and with less distortion [e.g. Diffusion Weighted Imaging (DWI)]. To test the feasibility of this concept, we developed a unilateral breast coil for 7T. It comprises a volume optimized dual-channel transmit coil combined with a 30-channel receive array coil. The high density of small coil elements enabled efficient acceleration in any direction to acquire ultra high spatial resolution MRI of close to 0.6 mm isotropic detail within a temporal resolution of 69 s, high spatial resolution MRI of 1.5 mm isotropic within an ultra high temporal resolution of 6.7 s and low distortion DWI at 7T, all validated in phantoms, healthy volunteers and a patient with a lesion in the right breast classified as Breast Imaging Reporting and Data System (BI-RADS) IV. Copyright © 2012 John Wiley & Sons, Ltd.

The High Time Resolution Universe surveys for pulsars and fast transients

NASA Astrophysics Data System (ADS)

Keith, Michael J.

2013-03-01

The High Time Resolution Universe survey for pulsars and transients is the first truly all-sky pulsar survey, taking place at the Parkes Radio Telescope in Australia and the Effelsberg Radio Telescope in Germany. Utilising multibeam receivers with custom built all-digital recorders the survey targets the fastest millisecond pulsars and radio transients on timescales of 64 μs to a few seconds. The new multibeam digital filter-bank system at has a factor of eight improvement in frequency resolution over previous Parkes multibeam surveys, allowing us to probe further into the Galactic plane for short duration signals. The survey is split into low, mid and high Galactic latitude regions. The mid-latitude portion of the southern hemisphere survey is now completed, discovering 107 previously unknown pulsars, including 26 millisecond pulsars. To date, the total number of discoveries in the combined survey is 135 and 29 MSPs These discoveries include the first magnetar to be discovered by it's radio emission, unusual low-mass binaries, gamma-ray pulsars and pulsars suitable for pulsar timing array experiments.

New developments in super-resolution for GaoFen-4

NASA Astrophysics Data System (ADS)

Li, Feng; Fu, Jie; Xin, Lei; Liu, Yuhong; Liu, Zhijia

2017-10-01

In this paper, the application of super resolution (SR, restoring a high spatial resolution image from a series of low resolution images of the same scene) techniques to GaoFen(GF)-4, which is the most advanced geostationaryorbit earth observing satellite in China, remote sensing images is investigated and tested. SR has been a hot research area for decades, but one of the barriers of applying SR in remote sensing community is the time slot between those low resolution (LR) images acquisition. In general, the longer the time slot, the less reliable the reconstruction. GF-4 has the unique advantage of capturing a sequence of LR of the same region in minutes, i.e. working as a staring camera from the point view of SR. This is the first experiment of applying super resolution to a sequence of low resolution images captured by GF-4 within a short time period. In this paper, we use Maximum a Posteriori (MAP) to solve the ill-conditioned problem of SR. Both the wavelet transform and the curvelet transform are used to setup a sparse prior for remote sensing images. By combining several images of both the BeiJing and DunHuang regions captured by GF-4 our method can improve spatial resolution both visually and numerically. Experimental tests show that lots of detail cannot be observed in the captured LR images, but can be seen in the super resolved high resolution (HR) images. To help the evaluation, Google Earth image can also be referenced. Moreover, our experimental tests also show that the higher the temporal resolution, the better the HR images can be resolved. The study illustrates that the application for SR to geostationary-orbit based earth observation data is very feasible and worthwhile, and it holds the potential application for all other geostationary-orbit based earth observing systems.

SNSMIL, a real-time single molecule identification and localization algorithm for super-resolution fluorescence microscopy

PubMed Central

Tang, Yunqing; Dai, Luru; Zhang, Xiaoming; Li, Junbai; Hendriks, Johnny; Fan, Xiaoming; Gruteser, Nadine; Meisenberg, Annika; Baumann, Arnd; Katranidis, Alexandros; Gensch, Thomas

2015-01-01

Single molecule localization based super-resolution fluorescence microscopy offers significantly higher spatial resolution than predicted by Abbe’s resolution limit for far field optical microscopy. Such super-resolution images are reconstructed from wide-field or total internal reflection single molecule fluorescence recordings. Discrimination between emission of single fluorescent molecules and background noise fluctuations remains a great challenge in current data analysis. Here we present a real-time, and robust single molecule identification and localization algorithm, SNSMIL (Shot Noise based Single Molecule Identification and Localization). This algorithm is based on the intrinsic nature of noise, i.e., its Poisson or shot noise characteristics and a new identification criterion, QSNSMIL, is defined. SNSMIL improves the identification accuracy of single fluorescent molecules in experimental or simulated datasets with high and inhomogeneous background. The implementation of SNSMIL relies on a graphics processing unit (GPU), making real-time analysis feasible as shown for real experimental and simulated datasets. PMID:26098742

UWB Tracking Algorithms: AOA and TDOA

NASA Technical Reports Server (NTRS)

Ni, Jianjun David; Arndt, D.; Ngo, P.; Gross, J.; Refford, Melinda

2006-01-01

Ultra-Wideband (UWB) tracking prototype systems are currently under development at NASA Johnson Space Center for various applications on space exploration. For long range applications, a two-cluster Angle of Arrival (AOA) tracking method is employed for implementation of the tracking system; for close-in applications, a Time Difference of Arrival (TDOA) positioning methodology is exploited. Both AOA and TDOA are chosen to utilize the achievable fine time resolution of UWB signals. This talk presents a brief introduction to AOA and TDOA methodologies. The theoretical analysis of these two algorithms reveal the affecting parameters impact on the tracking resolution. For the AOA algorithm, simulations show that a tracking resolution less than 0.5% of the range can be achieved with the current achievable time resolution of UWB signals. For the TDOA algorithm used in close-in applications, simulations show that the (sub-inch) high tracking resolution is achieved with a chosen tracking baseline configuration. The analytical and simulated results provide insightful guidance for the UWB tracking system design.

Object-based land cover classification and change analysis in the Baltimore metropolitan area using multitemporal high resolution remote sensing data

Treesearch

Weiqi Zhou; Austin Troy; Morgan Grove

2008-01-01

Accurate and timely information about land cover pattern and change in urban areas is crucial for urban land management decision-making, ecosystem monitoring and urban planning. This paper presents the methods and results of an object-based classification and post-classification change detection of multitemporal high-spatial resolution Emerge aerial imagery in the...

Explorer of Enceladus and Titan (E2T): Investigating ocean worlds' evolution and habitability in the solar system

NASA Astrophysics Data System (ADS)

Mitri, Giuseppe; Postberg, Frank; Soderblom, Jason M.; Wurz, Peter; Tortora, Paolo; Abel, Bernd; Barnes, Jason W.; Berga, Marco; Carrasco, Nathalie; Coustenis, Athena; Paul de Vera, Jean Pierre; D'Ottavio, Andrea; Ferri, Francesca; Hayes, Alexander G.; Hayne, Paul O.; Hillier, Jon K.; Kempf, Sascha; Lebreton, Jean-Pierre; Lorenz, Ralph D.; Martelli, Andrea; Orosei, Roberto; Petropoulos, Anastassios E.; Reh, Kim; Schmidt, Juergen; Sotin, Christophe; Srama, Ralf; Tobie, Gabriel; Vorburger, Audrey; Vuitton, Véronique; Wong, Andre; Zannoni, Marco

2018-06-01

Titan, with its organically rich and dynamic atmosphere and geology, and Enceladus, with its active plume, both harbouring global subsurface oceans, are prime environments in which to investigate the habitability of ocean worlds and the conditions for the emergence of life. We present a space mission concept, the Explorer of Enceladus and Titan (E2T), which is dedicated to investigating the evolution and habitability of these Saturnian satellites. E2T is proposed as a medium-class mission led by ESA in collaboration with NASA in response to ESA's M5 Cosmic Vision Call. E2T proposes a focused payload that would provide in-situ composition investigations and high-resolution imaging during multiple flybys of Enceladus and Titan using a solar-electric powered spacecraft in orbit around Saturn. The E2T mission would provide high-resolution mass spectrometry of the plume currently emanating from Enceladus' south polar terrain and of Titan's changing upper atmosphere. In addition, high-resolution infrared (IR) imaging would detail Titan's geomorphology at 50-100 m resolution and the temperature of the fractures on Enceladus' south polar terrain at meter resolution. These combined measurements of both Titan and Enceladus would enable the E2T mission scenario to achieve two major scientific goals: 1) Study the origin and evolution of volatile-rich ocean worlds; and 2) Explore the habitability and potential for life in ocean worlds. E2T's two high-resolution time-of-flight mass spectrometers would enable resolution of the ambiguities in chemical analysis left by the NASA/ESA/ASI Cassini-Huygens mission regarding the identification of low-mass organic species, detect high-mass organic species for the first time, further constrain trace species such as the noble gases, and clarify the evolution of solid and volatile species. The high-resolution IR camera would reveal the geology of Titan's surface and the energy dissipated by Enceladus' fractured south polar terrain and plume in detail unattainable by the Cassini mission.

Dynamic measurements of thermophysical properties of metals and alloys at high temperatures by subsecond pulse heating techniques

NASA Technical Reports Server (NTRS)

Cezairliyan, Ared

1993-01-01

Rapid (subsecond) heating techniques developed at the National Institute of Standards and Technology for the measurements of selected thermophysical and related properties of metals and alloys at high temperatures (above 1000 C) are described. The techniques are based on rapid resistive self-heating of the specimen from room temperature to the desired high temperature in short times and measuring the relevant experimental quantities, such as electrical current through the specimen, voltage across the specimen, specimen temperature, length, etc., with appropriate time resolution. The first technique, referred to as the millisecond-resolution technique, is for measurements on solid metals and alloys in the temperature range 1000 C to the melting temperature of the specimen. It utilizes a heavy battery bank for the energy source, and the total heating time of the specimen is typically in the range of 100-1000 ms. Data are recorded digitally every 0.5 ms with a full-scale resolution of about one part in 8000. The properties that can be measured with this system are as follows: specific heat, enthalpy, thermal expansion, electrical resistivity, normal spectral emissivity, hemispherical total emissivity, temperature and energy of solid-solid phase transformations, and melting temperature (solidus). The second technique, referred to as the microsecond-resolution technique, is for measurements on liquid metals and alloys in the temperature range 1200 to 6000 C. It utilizes a capacitor bank for the energy source, and the total heating time of the specimen is typically in the range 50-500 micro-s. Data are recorded digitally every 0.5 micro-s with a full-scale resolution of about one part in 4000. The properties that can be measured with this system are: melting temperature (solidus and liquidus), heat of fusion, specific heat, enthalpy, and electrical resistivity. The third technique is for measurements of the surface tension of liquid metals and alloys at their melting temperature. It utilizes a modified millisecond-resolution heating system designed for use in a microgravity environment.

SU-F-I-55: Performance Evaluation of Digital PET/CT: Medical Physics Basis for the Clinical Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, J; Knopp, MV; Miller, M

2016-06-15

Purpose: Replacement of conventional PMT-based detector with next generation digital photon counting (DPC) detector is a technology leap for PET imaging. This study evaluated the performance and characteristics of the DPC system and its stability within a 1 year time window following its installation focusing on the medical physics basis for clinical applications. Methods: A digital PET/CT scanner using 1:1 coupling of 23,040 crystal: detector elements was introduced and became operational at OSU. We tested and evaluated system performance and characteristics using NEMA NU2-2012. System stabilities in timing resolution, energy resolution, detector temperature and humidity (T&H) were monitored over 1-yr.more » Timing, energy and spatial resolution were characterized across clinically relevant count rate range. CQIE uniformity PET and NEMA IEC-Body PET with hot spheres varying with sizes and contrasts were performed. PET reconstructed in standard(4mm), High(2mm) and Ultra-High(1mm) definitions were evaluated. Results: NEMA results showed PET spatial resolution (mm-FWHM) from 4.01&4.14 at 1cm to 5.82&6.17 at 20cm in transverse & axial. 322±3ps timing and 11.0% energy resolution were measured. 5.7kcps/MBq system sensitivity with 24kcps/MBq effective sensitivity was obtained. The peak-NECR was ∼171kcps with the effective peak-NECR >650kcps@50kBq/mL. Scatter fraction was ∼30%, and the maximum trues was >900kcps. NEMA IQ demonstrated hot sphere contrast ranging from ∼62%±2%(10mm) to ∼88%±2%(22mm), cold sphere contrast of ∼86%±2%(28mm) and ∼89%±3%(37mm) and excellent uniformity. Monitoring 1-yr stability, it revealed ∼1% change in timing, ±0.4% change in energy resolution, and <10% variations in T&H. CQIE PET gave <3% SUV variances in axial. 60%–100% recovery coefficients across sphere sizes and contrast levels were achieved. Conclusion: Characteristics and stability of the next generation DPC PET detector system over an 1-yr time window was excellent and better than prior experiences. It demonstrated improved and robust system characteristics and performance in spatial resolution, sensitivity, timing and energy resolution, count rate and image quality. Michael Miller is an employee of Philips Healthcare.« less

Observations of volcanic hotspots with TET-1

NASA Astrophysics Data System (ADS)

Zakšek, Klemen; Hort, Matthias; Lorenz, Eckehard

2016-04-01

The most important source of uncertainties in thermal monitoring of active volcanoes from space stems from the lack of dedicated satellite instruments. Considering the currently available technology, we usually have to make a compromises between spatial and temporal resolution - if the data is available at high temporal resolution (from geostationary instruments), it is impossible to provide high spatial resolution data. The most promising solution seems to be a constellation of small satellites, for they can provide data at high spatial resolution and provide a short revisit time as there is a high number of satellites in the constellation. It is also difficult to provide narrow spectral channels at high radiometric accuracy for monitoring high and low temperatures at the same time. Instruments designed for meteorological applications are usually used in remote sensing of volcanic thermal anomalies. These instruments contain a mid-infrared channel, which provides crucial data for monitoring active volcanoes. However, the settings of meteorological instruments are optimized for monitoring low temperatures, which results in often saturated data over active volcanoes. The volcanological community can partially overcome the gap between the available meteorological satellites and its requirements with the small satellite TET-1 German abbreviation for "Technologie-Erprobungsträger 1" meaning Technology Experiment Carrier). TET-1 is the first satellite within the FireBird constellation. This consists of two small satellites which are predominantly dedicated to investigating high temperature events. They were built and are operated by the German Aerospace Center. TET-1 was launched in June 2012. Here we present the first results obtained from TET-1 data. The data were retrieved over several volcanoes: Etna, Stromboli, Bárdarbunga, etc. We show that using TET-1 data, it is possible to better constrain the time averaged lava discharge from other satellite data sources.

Accurate Finite Difference Algorithms

NASA Technical Reports Server (NTRS)

Goodrich, John W.

1996-01-01

Two families of finite difference algorithms for computational aeroacoustics are presented and compared. All of the algorithms are single step explicit methods, they have the same order of accuracy in both space and time, with examples up to eleventh order, and they have multidimensional extensions. One of the algorithm families has spectral like high resolution. Propagation with high order and high resolution algorithms can produce accurate results after O(10(exp 6)) periods of propagation with eight grid points per wavelength.

Quantifying the Uncertainty in High Spatial and Temporal Resolution Synthetic Land Surface Reflectance at Pixel Level Using Ground-Based Measurements

NASA Astrophysics Data System (ADS)

Kong, J.; Ryu, Y.

2017-12-01

Algorithms for fusing high temporal frequency and high spatial resolution satellite images are widely used to develop dense time-series land surface observations. While many studies have revealed that the synthesized frequent high spatial resolution images could be successfully applied in vegetation mapping and monitoring, validation and correction of fused images have not been focused than its importance. To evaluate the precision of fused image in pixel level, in-situ reflectance measurements which could account for the pixel-level heterogeneity are necessary. In this study, the synthetic images of land surface reflectance were predicted by the coarse high-frequency images acquired from MODIS and high spatial resolution images from Landsat-8 OLI using the Flexible Spatiotemporal Data Fusion (FSDAF). Ground-based reflectance was measured by JAZ Spectrometer (Ocean Optics, Dunedin, FL, USA) on rice paddy during five main growth stages in Cheorwon-gun, Republic of Korea, where the landscape heterogeneity changes through the growing season. After analyzing the spatial heterogeneity and seasonal variation of land surface reflectance based on the ground measurements, the uncertainties of the fused images were quantified at pixel level. Finally, this relationship was applied to correct the fused reflectance images and build the seasonal time series of rice paddy surface reflectance. This dataset could be significant for rice planting area extraction, phenological stages detection, and variables estimation.

Evaluation of a Mesoscale Convective System in Variable-Resolution CESM

NASA Astrophysics Data System (ADS)

Payne, A. E.; Jablonowski, C.

2017-12-01

Warm season precipitation over the Southern Great Plains (SGP) follows a well observed diurnal pattern of variability, peaking at night-time, due to the eastward propagation of mesoscale convection systems that develop over the eastern slopes of the Rockies in the late afternoon. While most climate models are unable to adequately capture the organization of convection and characteristic pattern of precipitation over this region, models with high enough resolution to explicitly resolve convection show improvement. However, high resolution simulations are computationally expensive and, in the case of regional climate models, are subject to boundary conditions. Newly developed variable resolution global climate models strike a balance between the benefits of high-resolution regional climate models and the large-scale dynamics of global climate models and low computational cost. Recently developed parameterizations that are insensitive to the model grid scale provide a way to improve model performance. Here, we present an evaluation of the newly available Cloud Layers Unified by Binormals (CLUBB) parameterization scheme in a suite of variable-resolution CESM simulations with resolutions ranging from 110 km to 7 km within a regionally refined region centered over the SGP Atmospheric Radiation Measurement (ARM) site. Simulations utilize the hindcast approach developed by the Department of Energy's Cloud-Associated Parameterizations Testbed (CAPT) for the assessment of climate models. We limit our evaluation to a single mesoscale convective system that passed over the region on May 24, 2008. The effects of grid-resolution on the timing and intensity of precipitation, as well as, on the transition from shallow to deep convection are assessed against ground-based observations from the SGP ARM site, satellite observations and ERA-Interim reanalysis.

Determining seagrass abundance in southern New England waters using high resolution remotely sensed imagery

EPA Science Inventory

Advances in understanding the optics of shallow water environments, submerged vegetation canopies and seagrass physiology, combined with improved spatial resolution of remote sensing platforms, now enable eelgrass ecosystems to be monitored at a variety of time scales from earth-...

Ultrafast Bilateral DCE-MRI of the Breast with Conventional Fourier Sampling: Preliminary Evaluation of Semi-quantitative Analysis.

PubMed

Pineda, Federico D; Medved, Milica; Wang, Shiyang; Fan, Xiaobing; Schacht, David V; Sennett, Charlene; Oto, Aytekin; Newstead, Gillian M; Abe, Hiroyuki; Karczmar, Gregory S

2016-09-01

The study aimed to evaluate the feasibility and advantages of a combined high temporal and high spatial resolution protocol for dynamic contrast-enhanced magnetic resonance imaging of the breast. Twenty-three patients with enhancing lesions were imaged at 3T. The acquisition protocol consisted of a series of bilateral, fat-suppressed "ultrafast" acquisitions, with 6.9- to 9.9-second temporal resolution for the first minute following contrast injection, followed by four high spatial resolution acquisitions with 60- to 79.5-second temporal resolution. All images were acquired with standard uniform Fourier sampling. A filtering method was developed to reduce noise and detect significant enhancement in the high temporal resolution images. Time of arrival (TOA) was defined as the time at which each voxel first satisfied all the filter conditions, relative to the time of initial arterial enhancement. Ultrafast images improved visualization of the vasculature feeding and draining lesions. A small percentage of the entire field of view (<6%) enhanced significantly in the 30 seconds following contrast injection. Lesion conspicuity was highest in early ultrafast images, especially in cases with marked parenchymal enhancement. Although the sample size was relatively small, the average TOA for malignant lesions was significantly shorter than the TOA for benign lesions. Significant differences were also measured in other parameters descriptive of early contrast media uptake kinetics (P < 0.05). Ultrafast imaging in the first minute of dynamic contrast-enhanced magnetic resonance imaging of the breast has the potential to add valuable information on early contrast dynamics. Ultrafast imaging could allow radiologists to confidently identify lesions in the presence of marked background parenchymal enhancement. Copyright © 2016 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.

High Resolution PTR-TOFMS: A New Instrument for Organic Compound Measurements

NASA Astrophysics Data System (ADS)

Hansel, A.; Graus, M.; Mueller, M.; Wisthaler, A.

2007-12-01

Over the last decade proton transfer reaction mass spectrometry (PTR-MS) has become very popular in many scientific fields. PTR-MS allows for the quantitative detection of volatile organic compounds (VOCs) at pptv-level virtually in real time. Monitoring of VOCs with a time resolution of typically a second per compound has, for instance, enabled the tracking of pollution plumes by air-borne measurements, thus revealing the photo- chemical fate of pollutants. It has also been employed in direct eddy covariant flux measurements. This rapidity, however, has been achieved at the cost of the number of compounds to be analyzed and compound selectivity. Conventional PTR-MS can, for example, not distinguish between hydrocarbons and their oxygenated isobaric species, e.g. between naphthalene and octanal or between isoprene and furan. In a mass range up to 200 Dalton, such a task would require a mass resolving power of 5500. The use of a time of flight (TOF) instead of a quadrupole mass analyzer in PTR-MS provides a sufficient high mass resolution to identify the atomic composition of product ions by their exact mass and their characteristic isotope patterns. In addition PTR-TOF-MS can record full mass spectra within a fraction of a second which is a dramatically increase in duty cycle. At the University of Innsbruck a high resolution PTR-TOFMS has recently been developed, coupling a PTR-ion source and a high resolution TOFMS. We achieved a mass resolving power of 6000 (FWHM), and a detection limit of tens to a few hundreds of pptv if integrating mass spectra for one minute. First results and future directions will be discussed in this paper.

High resolution modeling in urban hydrology: comparison between two modeling approaches and their sensitivity to high rainfall variability

NASA Astrophysics Data System (ADS)

Ichiba, Abdellah; Gires, Auguste; Tchiguirinskaia, Ioulia; Bompard, Philippe; Schertzer, Daniel

2015-04-01

Urban water management is becoming increasingly complex, due to the rapid increase of impervious areas, and the potential effects of climate change. The large amount of water generated in a very short period of time and the limited capacity of sewer systems increase the vulnerability of urban environments to flooding risk and make it necessary to implement specific devices in order to handle the volume of water generated. This complex situation in urban environments makes the use of hydrological models as well as the implementation of more accurate and reliable tools for flow and rainfall measurements essential for a good pluvial network management, the use of decision support tools such as real-time radar forecasting system, the developpement of general public communication and warning systems, and the implementation of management strategy participate on limiting the flood damages. The very high spatial variability characteristic of urban environments makes it necessary to integrate the variability of physical properties and precipitation at fine scales in modeling processes, suggesting a high resolution modeling approach. In this paper we suggest a comparison between two modeling approaches and their sensitivity to small-scale rainfall variability on a 2.15 km2 urban area located in the County of Val-de-Marne (South-East of Paris, France). The first model used in this study is CANOE, which is a semi-distributed model widely used in France by practitioners for urban hydrology and urban water management. Two configurations of this model are be used in this study, the first one integrate 9 sub-catchments with sizes range from (1ha to 76ha), in the second configuration, the spatial resolution of this model has been improved with 45 sub-catchments with sizes range from (1ha to 14ha), the aim is to see how the semi-distributed model resolution affects it sensitivity to rainfall variability. The second model is Multi-Hydro fully distributed model developed at the Ecole des Ponts ParisTech. It is an interacting core between open source software packages, each of them representing a portion of the water cycle in urban environment. Multi-Hydro has been set up at two resolutions, 10m and 5m. The validation of these two models is performed using 5 rainfall events that occurred between 2010 and 2013. Radar data comes from the Météo-France radar mosaic and the resolution is 1 km in space and 5 min in time. Raingauge and flow measurements data comes from the General Council of Val-de-Marne County. In this validation part, the hydrological responses given by two models and the different configurations are compared to flow measurements. It appears that CANOE gives better results than Multi-Hydro model, especially when using raingauge data. For some events, we noticed that model responses given when using raingauge and radar data are different, suggesting a sign of sensitivity to the spatial variability of rainfall. 10 high-resolution rainfall events are used in the second part to study the sensitivity of each modeling approach to high rainfall variability. Radar data was available at four spatial resolutions (100, 200, 500 and 1000m) and two temporal resolutions (1min and 5min), for each event, two rainfall directions (parallel and perpendicular) are used, meaning that 16 hydrological responses are simulated for each event and the variability within it analyzed. First results suggest that the fully distributed model is more sensitive to high rainfall variability than the semi-distributed one, the increase of both hydrological model spatial resolution improves their sensitivity to rainfall variability. This study highlights some technical challenges facing the high-resolution modeling, especially the difficulty to obtain reliable input data at an acceptable resolution and also the high computation time noticed particularly for the semi-distributed model making it difficult to use it in real time. The authors greatly acknowledge partial financial support from the project RainGain (http://www.raingain.eu) of the EU Interreg program.

A quartz-based micro catalytic methane sensor by high resolution screen printing

NASA Astrophysics Data System (ADS)

Lu, Wenshuai; Jing, Gaoshan; Bian, Xiaomeng; Yu, Hongyan; Cui, Tianhong

2016-02-01

A micro catalytic methane sensor was proposed and fabricated on a bulk fused quartz substrate using a high resolution screen printing technique for the first time, with reduced power consumption and optimized sensitivity. The sensor was designed by the finite element method and quartz was chosen as the substrate material and alumina support with optimized dimensions. Fabrication of the sensor consisted of two MEMS processes, lift-off and high resolution screen printing, with the advantages of high yield and uniformity. When the sensor’s regional working temperature changes from 250 °C to 470 °C, its sensitivity increases, as well as the power consumption. The highest sensitivity can reach 1.52 mV/% CH4. A temperature of 300 °C was chosen as the optimized working temperature, and the sensor’s sensitivity, power consumption, nonlinearity and response time are 0.77 mV/% CH4, 415 mW, 2.6%, and 35 s, respectively. This simple, but highly uniform fabrication process and the reliable performance of this sensor may lead to wide applications for methane detection.

Quantifying Surface Water Dynamics at 30 Meter Spatial Resolution in the North American High Northern Latitudes 1991-2011

NASA Technical Reports Server (NTRS)

Carroll, Mark; Wooten, Margaret; DiMiceli, Charlene; Sohlberg, Robert; Kelly, Maureen

2016-01-01

The availability of a dense time series of satellite observations at moderate (30 m) spatial resolution is enabling unprecedented opportunities for understanding ecosystems around the world. A time series of data from Landsat was used to generate a series of three maps at decadal time step to show how surface water has changed from 1991 to 2011 in the high northern latitudes of North America. Previous attempts to characterize the change in surface water in this region have been limited in either spatial or temporal resolution, or both. This series of maps was generated for the NASA Arctic and Boreal Vulnerability Experiment (ABoVE), which began in fall 2015. These maps show a nominal extent of surface water by using multiple observations to make a single map for each time step. This increases the confidence that any detected changes are related to climate or ecosystem changes not simply caused by short duration weather events such as flood or drought. The methods and comparison to other contemporary maps of the region are presented here. Initial verification results indicate 96% producer accuracy and 54% user accuracy when compared to 2-m resolution World View-2 data. All water bodies that were omitted were one Landsat pixel or smaller, hence below detection limits of the instrument.

Agent-based Large-Scale Emergency Evacuation Using Real-Time Open Government Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lu, Wei; Liu, Cheng; Bhaduri, Budhendra L

The open government initiatives have provided tremendous data resources for the transportation system and emergency services in urban areas. This paper proposes a traffic simulation framework using high temporal resolution demographic data and real time open government data for evacuation planning and operation. A comparison study using real-world data in Seattle, Washington is conducted to evaluate the framework accuracy and evacuation efficiency. The successful simulations of selected area prove the concept to take advantage open government data, open source data, and high resolution demographic data in emergency management domain. There are two aspects of parameters considered in this study: usermore » equilibrium (UE) conditions of traffic assignment model (simple Non-UE vs. iterative UE) and data temporal resolution (Daytime vs. Nighttime). Evacuation arrival rate, average travel time, and computation time are adopted as Measure of Effectiveness (MOE) for evacuation performance analysis. The temporal resolution of demographic data has significant impacts on urban transportation dynamics during evacuation scenarios. Better evacuation performance estimation can be approached by integrating both Non-UE and UE scenarios. The new framework shows flexibility in implementing different evacuation strategies and accuracy in evacuation performance. The use of this framework can be explored to day-to-day traffic assignment to support daily traffic operations.« less

Time-Resolved Molecular Characterization of Limonene/Ozone Aerosol using High-Resolution Electrospray Ionization Mass Spectrometry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bateman, Adam P.; Nizkorodov, Serguei; Laskin, Julia

2009-09-09

Molecular composition of limonene/O3 secondary organic aerosol (SOA) was investigated using high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) as a function of reaction time. SOA was generated by ozonation of D-limonene in a reaction chamber and sampled at different time intervals using a cascade impactor. The SOA samples were extracted into acetonitrile and analyzed using a HR-ESI-MS instrument with a resolving power of 100,000 (m/Δm). The resulting mass spectra provided detailed information about the extent of oxidation inferred from the O:C ratios, double bond equivalency (DBE) factors, and aromaticity indexes (AI) in hundreds of identified individual SOA species.

Ultrafast compression of graphite observed with sub-ps time resolution diffraction on LCLS

NASA Astrophysics Data System (ADS)

Armstrong, Michael; Goncharov, A.; Crowhurst, J.; Zaug, J.; Radousky, H.; Grivickas, P.; Bastea, S.; Goldman, N.; Stavrou, E.; Belof, J.; Gleason, A.; Lee, H. J.; Nagler, R.; Holtgrewe, N.; Walter, P.; Pakaprenka, V.; Nam, I.; Granados, E.; Presher, C.; Koroglu, B.

2017-06-01

We will present ps time resolution pulsed x-ray diffraction measurements of rapidly compressed highly oriented pyrolytic graphite along its basal plane at the Materials under Extreme Conditions (MEC) sector of the Linac Coherent Light Source (LCLS). These experiments explore the possibility of rapid (<100 ps time scale) material transformations occurring under very highly anisotropic compression conditions. Under such conditions, non-equilibrium mechanisms may play a role in the transformation process. We will present experimental results and simulations which explore this possibility. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Security, LLC under Contract DE-AC52-07NA27344.

The High Time Resolution Universe

NASA Astrophysics Data System (ADS)

Bailes, Matthew; Possenti, Andrea; Johnston, Simon; Kramer, Michael; Burgay, Marta; Bhat, Ramesh; Keith, Michael; Burke-Spolaor, Sarah; van Straten, Willem; Stappers, Benjamin; Bates, Samuel

2008-04-01

The Parkes multibeam surveys heralded a new era in pulsar surveys, more than doubling the number of pulsars known. However, at high time resolution, they were severely limited by the analogue backend system, which limited the volume of sky they could effectively survey to just the local 2-3 kpc. Here we propose to use a new digital backend coupled with Australia's most powerful (16 Tflop) supercomputing cluster to conduct three ambitious surveys for millisecond and relativistic pulsars with the Parkes telescope. We hope to discover over 200 new millisecond and relativistic pulsars that will define the recycled pulsar period distribution, supply pulsars for the timing array and aid in our understanding of binary evolution.

Fast Timing for High-Rate Environments with Micromegas

NASA Astrophysics Data System (ADS)

Papaevangelou, Thomas; Desforge, Daniel; Ferrer-Ribas, Esther; Giomataris, Ioannis; Godinot, Cyprien; Diaz, Diego Gonzalez; Gustavsson, Thomas; Kebbiri, Mariam; Oliveri, Eraldo; Resnati, Filippo; Ropelewski, Leszek; Tsiledakis, Georgios; Veenhof, Rob; White, Sebastian

2018-02-01

The current state of the art in fast timing resolution for existing experiments is of the order of 100 ps on the time of arrival of both charged particles and electromagnetic showers. Current R&D on charged particle timing is approaching the level of 10 ps but is not primarily directed at sustained performance at high rates and under high radiation (as would be needed for HL-LHC pileup mitigation). We demonstrate aMicromegas based solution to reach this level of performance. The Micromegas acts as a photomultiplier coupled to a Cerenkovradiator front window, which produces sufficient UV photons to convert the ˜100 ps single-photoelectron jitter into a timing response of the order of 10-20 ps per incident charged particle. A prototype has been built in order to demonstrate this performance. The first laboratory tests with a pico-second laser have shown a time resolution of the order of 27 ps for ˜50 primary photoelectrons, using a bulk Micromegas readout.

A novel super-resolution camera model

NASA Astrophysics Data System (ADS)

Shao, Xiaopeng; Wang, Yi; Xu, Jie; Wang, Lin; Liu, Fei; Luo, Qiuhua; Chen, Xiaodong; Bi, Xiangli

2015-05-01

Aiming to realize super resolution(SR) to single image and video reconstruction, a super resolution camera model is proposed for the problem that the resolution of the images obtained by traditional cameras behave comparatively low. To achieve this function we put a certain driving device such as piezoelectric ceramics in the camera. By controlling the driving device, a set of continuous low resolution(LR) images can be obtained and stored instantaneity, which reflect the randomness of the displacements and the real-time performance of the storage very well. The low resolution image sequences have different redundant information and some particular priori information, thus it is possible to restore super resolution image factually and effectively. The sample method is used to derive the reconstruction principle of super resolution, which analyzes the possible improvement degree of the resolution in theory. The super resolution algorithm based on learning is used to reconstruct single image and the variational Bayesian algorithm is simulated to reconstruct the low resolution images with random displacements, which models the unknown high resolution image, motion parameters and unknown model parameters in one hierarchical Bayesian framework. Utilizing sub-pixel registration method, a super resolution image of the scene can be reconstructed. The results of 16 images reconstruction show that this camera model can increase the image resolution to 2 times, obtaining images with higher resolution in currently available hardware levels.

Note: Fully integrated time-to-amplitude converter in Si-Ge technology.

PubMed

Crotti, M; Rech, I; Ghioni, M

2010-10-01

Over the past years an always growing interest has arisen about the measurement technique of time-correlated single photon counting TCSPC), since it allows the analysis of extremely fast and weak light waveforms with a picoseconds resolution. Consequently, many applications exploiting TCSPC have been developed in several fields such as medicine and chemistry. Moreover, the development of multianode PMT and of single photon avalanche diode arrays led to the realization of acquisition systems with several parallel channels to employ the TCSPC technique in even more applications. Since TCSPC basically consists of the measurement of the arrival time of a photon, the most important part of an acquisition chain is the time measurement block, which must have high resolution and low differential nonlinearity, and in order to realize multidimensional systems, it has to be integrated to reduce both cost and area. In this paper we present a fully integrated time-to-amplitude converter, built in 0.35 μm Si-Ge technology, characterized by a good time resolution (60 ps), low differential nonlinearity (better than 3% peak to peak), high counting rate (16 MHz), low and constant power dissipation (40 mW), and low area occupation (1.38×1.28 mm(2)).

Rapid simultaneous high-resolution mapping of myelin water fraction and relaxation times in human brain using BMC-mcDESPOT.

PubMed

Bouhrara, Mustapha; Spencer, Richard G

2017-02-15

A number of central nervous system (CNS) diseases exhibit changes in myelin content and magnetic resonance longitudinal, T 1 , and transverse, T 2 , relaxation times, which therefore represent important biomarkers of CNS pathology. Among the methods applied for measurement of myelin water fraction (MWF) and relaxation times, the multicomponent driven equilibrium single pulse observation of T 1 and T 2 (mcDESPOT) approach is of particular interest. mcDESPOT permits whole brain mapping of multicomponent T 1 and T 2 , with data acquisition accomplished within a clinically realistic acquisition time. Unfortunately, previous studies have indicated the limited performance of mcDESPOT in the setting of the modest signal-to-noise range of high-resolution mapping, required for the depiction of small structures and to reduce partial volume effects. Recently, we showed that a new Bayesian Monte Carlo (BMC) analysis substantially improved determination of MWF from mcDESPOT imaging data. However, our previous study was limited in that it did not discuss determination of relaxation times. Here, we extend the BMC analysis to the simultaneous determination of whole-brain MWF and relaxation times using the two-component mcDESPOT signal model. Simulation analyses and in-vivo human brain studies indicate the overall greater performance of this approach compared to the stochastic region contraction (SRC) algorithm, conventionally used to derive parameter estimates from mcDESPOT data. SRC estimates of the transverse relaxation time of the long T 2 fraction, T 2,l , and the longitudinal relaxation time of the short T 1 fraction, T 1,s , clustered towards the lower and upper parameter search space limits, respectively, indicating failure of the fitting procedure. We demonstrate that this effect is absent in the BMC analysis. Our results also showed improved parameter estimation for BMC as compared to SRC for high-resolution mapping. Overall we find that the combination of BMC analysis and mcDESPOT, BMC-mcDESPOT, shows excellent performance for accurate high-resolution whole-brain mapping of MWF and bi-component transverse and longitudinal relaxation times within a clinically realistic acquisition time. Published by Elsevier Inc.

Enhanced spectral resolution by high-dimensional NMR using the filter diagonalization method and "hidden" dimensions.

PubMed

Meng, Xi; Nguyen, Bao D; Ridge, Clark; Shaka, A J

2009-01-01

High-dimensional (HD) NMR spectra have poorer digital resolution than low-dimensional (LD) spectra, for a fixed amount of experiment time. This has led to "reduced-dimensionality" strategies, in which several LD projections of the HD NMR spectrum are acquired, each with higher digital resolution; an approximate HD spectrum is then inferred by some means. We propose a strategy that moves in the opposite direction, by adding more time dimensions to increase the information content of the data set, even if only a very sparse time grid is used in each dimension. The full HD time-domain data can be analyzed by the filter diagonalization method (FDM), yielding very narrow resonances along all of the frequency axes, even those with sparse sampling. Integrating over the added dimensions of HD FDM NMR spectra reconstitutes LD spectra with enhanced resolution, often more quickly than direct acquisition of the LD spectrum with a larger number of grid points in each of the fewer dimensions. If the extra-dimensions do not appear in the final spectrum, and are used solely to boost information content, we propose the moniker hidden-dimension NMR. This work shows that HD peaks have unmistakable frequency signatures that can be detected as single HD objects by an appropriate algorithm, even though their patterns would be tricky for a human operator to visualize or recognize, and even if digital resolution in an HD FT spectrum is very coarse compared with natural line widths.

Enhanced spectral resolution by high-dimensional NMR using the filter diagonalization method and “hidden” dimensions

PubMed Central

Meng, Xi; Nguyen, Bao D.; Ridge, Clark; Shaka, A. J.

2009-01-01

High-dimensional (HD) NMR spectra have poorer digital resolution than low-dimensional (LD) spectra, for a fixed amount of experiment time. This has led to “reduced-dimensionality” strategies, in which several LD projections of the HD NMR spectrum are acquired, each with higher digital resolution; an approximate HD spectrum is then inferred by some means. We propose a strategy that moves in the opposite direction, by adding more time dimensions to increase the information content of the data set, even if only a very sparse time grid is used in each dimension. The full HD time-domain data can be analyzed by the Filter Diagonalization Method (FDM), yielding very narrow resonances along all of the frequency axes, even those with sparse sampling. Integrating over the added dimensions of HD FDM NMR spectra reconstitutes LD spectra with enhanced resolution, often more quickly than direct acquisition of the LD spectrum with a larger number of grid points in each of the fewer dimensions. If the extra dimensions do not appear in the final spectrum, and are used solely to boost information content, we propose the moniker hidden-dimension NMR. This work shows that HD peaks have unmistakable frequency signatures that can be detected as single HD objects by an appropriate algorithm, even though their patterns would be tricky for a human operator to visualize or recognize, and even if digital resolution in an HD FT spectrum is very coarse compared with natural line widths. PMID:18926747

Note: All-digital CMOS MOS-capacitor-based pulse-shrinking mechanism suitable for time-to-digital converters

NASA Astrophysics Data System (ADS)

Chen, Chun-Chi; Hwang, Chorng-Sii; Lin, You-Ting; Liu, Keng-Chih

2015-12-01

This paper presents an all-digital CMOS pulse-shrinking mechanism suitable for time-to-digital converters (TDCs). A simple MOS capacitor is used as a pulse-shrinking cell to perform time attenuation for time resolving. Compared with a previous pulse-shrinking mechanism, the proposed mechanism provides an appreciably improved temporal resolution with high linearity. Furthermore, the use of a binary-weighted pulse-shrinking unit with scaled MOS capacitors is proposed for achieving a programmable resolution. A TDC involving the proposed mechanism was fabricated using a TSMC (Taiwan Semiconductor Manufacturing Company) 0.18-μm CMOS process, and it has a small area of nearly 0.02 mm2 and an integral nonlinearity error of ±0.8 LSB for a resolution of 24 ps.

Time-resolved lidar fluorosensor for sea pollution detection

NASA Technical Reports Server (NTRS)

Ferrario, A.; Pizzolati, P. L.; Zanzottera, E.

1986-01-01

A contemporary time and spectral analysis of oil fluorescence is useful for the detection and the characterization of oil spills on the sea surface. Nevertheless the fluorosensor lidars, which were realized up to now, have only partial capability to perform this double analysis. The main difficulties are the high resolution required (of the order of 1 nanosecond) and the complexity of the detection system for the recording of a two-dimensional matrix of data for each laser pulse. An airborne system whose major specifications were: time range, 30 to 75 ns; time resolution, 1 ns; spectral range, 350 to 700 nm; and spectral resolution, 10 nm was designed and constructed. The designed system of a short pulse ultraviolet laser source and a streak camera based detector are described.

A high space-time resolution dataset linking meteorological forcing and hydro-sedimentary response in a mesoscale Mediterranean catchment (Auzon) of the Ardèche region, France

NASA Astrophysics Data System (ADS)

Nord, Guillaume; Boudevillain, Brice; Berne, Alexis; Branger, Flora; Braud, Isabelle; Dramais, Guillaume; Gérard, Simon; Le Coz, Jérôme; Legoût, Cédric; Molinié, Gilles; Van Baelen, Joel; Vandervaere, Jean-Pierre; Andrieu, Julien; Aubert, Coralie; Calianno, Martin; Delrieu, Guy; Grazioli, Jacopo; Hachani, Sahar; Horner, Ivan; Huza, Jessica; Le Boursicaud, Raphaël; Raupach, Timothy H.; Teuling, Adriaan J.; Uber, Magdalena; Vincendon, Béatrice; Wijbrans, Annette

2017-03-01

A comprehensive hydrometeorological dataset is presented spanning the period 1 January 2011-31 December 2014 to improve the understanding of the hydrological processes leading to flash floods and the relation between rainfall, runoff, erosion and sediment transport in a mesoscale catchment (Auzon, 116 km2) of the Mediterranean region. Badlands are present in the Auzon catchment and well connected to high-gradient channels of bedrock rivers which promotes the transfer of suspended solids downstream. The number of observed variables, the various sensors involved (both in situ and remote) and the space-time resolution ( ˜ km2, ˜ min) of this comprehensive dataset make it a unique contribution to research communities focused on hydrometeorology, surface hydrology and erosion. Given that rainfall is highly variable in space and time in this region, the observation system enables assessment of the hydrological response to rainfall fields. Indeed, (i) rainfall data are provided by rain gauges (both a research network of 21 rain gauges with a 5 min time step and an operational network of 10 rain gauges with a 5 min or 1 h time step), S-band Doppler dual-polarization radars (1 km2, 5 min resolution), disdrometers (16 sensors working at 30 s or 1 min time step) and Micro Rain Radars (5 sensors, 100 m height resolution). Additionally, during the special observation period (SOP-1) of the HyMeX (Hydrological Cycle in the Mediterranean Experiment) project, two X-band radars provided precipitation measurements at very fine spatial and temporal scales (1 ha, 5 min). (ii) Other meteorological data are taken from the operational surface weather observation stations of Météo-France (including 2 m air temperature, atmospheric pressure, 2 m relative humidity, 10 m wind speed and direction, global radiation) at the hourly time resolution (six stations in the region of interest). (iii) The monitoring of surface hydrology and suspended sediment is multi-scale and based on nested catchments. Three hydrometric stations estimate water discharge at a 2-10 min time resolution. Two of these stations also measure additional physico-chemical variables (turbidity, temperature, conductivity) and water samples are collected automatically during floods, allowing further geochemical characterization of water and suspended solids. Two experimental plots monitor overland flow and erosion at 1 min time resolution on a hillslope with vineyard. A network of 11 sensors installed in the intermittent hydrographic network continuously measures water level and water temperature in headwater subcatchments (from 0.17 to 116 km2) at a time resolution of 2-5 min. A network of soil moisture sensors enables the continuous measurement of soil volumetric water content at 20 min time resolution at 9 sites. Additionally, concomitant observations (soil moisture measurements and stream gauging) were performed during floods between 2012 and 2014. Finally, this dataset is considered appropriate for understanding the rainfall variability in time and space at fine scales, improving areal rainfall estimations and progressing in distributed hydrological and erosion modelling. DOI of the referenced dataset: doi:10.6096/MISTRALS-HyMeX.1438.

Real-time bilinear rotation decoupling in absorptive mode J-spectroscopy: Detecting low-intensity metabolite peak close to high-intensity metabolite peak with convenience.

PubMed

Verma, Ajay; Baishya, Bikash

2016-05-01

"Pure shift" NMR spectra display singlet peak per chemical site. Thus, high resolution is offered at the cost of valuable J-coupling information. In the present work, real-time BIRD (BIlinear Rotation Decoupling) is applied to the absorptive-mode 2D J-spectroscopy to provide pure shift spectrum in the direct dimension and J-coupling information in the indirect dimension. Quite often in metabolomics, proton NMR spectra from complex bio-fluids display tremendous signal overlap. Although conventional J-spectroscopy in principle overcomes this problem by separating the multiplet information from chemical shift information, however, only magnitude mode of the experiment is practical, sacrificing much of the potential high resolution that could be achieved. Few J-spectroscopy methods have been reported so far that produce high-resolution pure shift spectrum along with J-coupling information for crowded spectral regions. In the present work, high-quality J-resolved spectrum from important metabolomic mixture such as tissue extract from rat cortex is demonstrated. Many low-intensity metabolite peaks which are obscured by the broad dispersive tails from high-intensity metabolite peaks in regular magnitude mode J-spectrum can be clearly identified in real-time BIRD J-resolved spectrum. The general practice of removing such spectral overlap is tedious and time-consuming as it involves repeated sample preparation to change the pH of the tissue extract sample and subsequent spectra recording. Copyright © 2016 Elsevier Inc. All rights reserved.

Real-time bilinear rotation decoupling in absorptive mode J-spectroscopy: Detecting low-intensity metabolite peak close to high-intensity metabolite peak with convenience

NASA Astrophysics Data System (ADS)

Verma, Ajay; Baishya, Bikash

2016-05-01

;Pure shift; NMR spectra display singlet peak per chemical site. Thus, high resolution is offered at the cost of valuable J-coupling information. In the present work, real-time BIRD (BIlinear Rotation Decoupling) is applied to the absorptive-mode 2D J-spectroscopy to provide pure shift spectrum in the direct dimension and J-coupling information in the indirect dimension. Quite often in metabolomics, proton NMR spectra from complex bio-fluids display tremendous signal overlap. Although conventional J-spectroscopy in principle overcomes this problem by separating the multiplet information from chemical shift information, however, only magnitude mode of the experiment is practical, sacrificing much of the potential high resolution that could be achieved. Few J-spectroscopy methods have been reported so far that produce high-resolution pure shift spectrum along with J-coupling information for crowded spectral regions. In the present work, high-quality J-resolved spectrum from important metabolomic mixture such as tissue extract from rat cortex is demonstrated. Many low-intensity metabolite peaks which are obscured by the broad dispersive tails from high-intensity metabolite peaks in regular magnitude mode J-spectrum can be clearly identified in real-time BIRD J-resolved spectrum. The general practice of removing such spectral overlap is tedious and time-consuming as it involves repeated sample preparation to change the pH of the tissue extract sample and subsequent spectra recording.

High-resolution absorption measurements of NH3 at high temperatures: 2100-5500 cm-1

NASA Astrophysics Data System (ADS)

Barton, Emma J.; Yurchenko, Sergei N.; Tennyson, Jonathan; Clausen, Sønnik; Fateev, Alexander

2017-03-01

High-resolution absorption spectra of NH3 in the region 2100-5500 cm-1 at 1027 °C and approximately atmospheric pressure (1045±3 mbar) are measured. An NH3 concentration of 10% in volume fraction is used in the measurements. Spectra are recorded in a high-temperature gas-flow cell using a Fourier Transform Infrared (FTIR) spectrometer at a nominal resolution of 0.09 cm-1. The spectra are analysed by comparison to a variational line list, BYTe, and experimental energy levels determined using the MARVEL procedure. 2308 lines have been assigned to 45 different bands, of which 1755 and 15 have been assigned or observed for the first time in this work.

High-resolution AM LCD development for avionic applications

NASA Astrophysics Data System (ADS)

Lamberth, Larry S.; Laddu, Ravindra R.; Harris, Doug; Sarma, Kalluri R.; Li, Wang-Yang; Chien, C. C.; Chu, C. Y.; Lee, C. S.; Kuo, Chen-Lung

2003-09-01

For the first time, an avionic grade MVA AM LCD with wide viewing angle has been developed for use in either landscape or portrait mode. The development of a high resolution Multi-domain Vertical Alignment (MVA) Active Matrix Liquid Crystal Display (AM LCD) is described. Challenges met in this development include achieving the required performance with high luminance and sunlight readability while meeting stringent optical (image quality) and environmental performance requirements of avionics displays. In this paper the optical and environmental performance of this high resolution 14.1" MVA-AM-LCD are discussed and some performance comparisons to conventional AM-LCDs are documented. This AM LCD has found multiple Business Aviation and Military display applications and cockpit pictures are presented.

Space-time development of electromagnetic and hadronic showers and perspectives for novel calorimetric techniques

DOE PAGES

Benaglia, Andrea; Auffray, Etiennette; Lecoq, Paul; ...

2016-04-20

The performance of hadronic calorimeters will be a key parameter at the next generation of High Energy Physics accelerators. A detector combining fine granularity with excellent timing information would prove beneficial for the reconstruction of both jets and electromagnetic particles with high energy resolution. In this work, the space and time structure of high energy showers is studied by means of a Geant4-based simulation toolkit. In particular, the relevant time scales of the different physics phenomena contributing to the energy loss are investigated. A correlation between the fluctuations of the energy deposition of high energy hadrons and the time developmentmore » of the showers is observed, which allows for an event-by-event correction to be computed to improve the energy resolution of the calorimeter. Lastly, these studies are intended to set the basic requirements for the development of a new-concept, total absorption time-imaging calorimeter, which seems now within reach thanks to major technological advancements in the production of fast scintillating materials and compact photodetectors.« less

High-resolution frequency-domain second-harmonic optical coherence tomography

NASA Astrophysics Data System (ADS)

Su, Jianping; Tomov, Ivan V.; Jiang, Yi; Chen, Zhongping

2007-04-01

We used continuum generated in an 8.5 cm long fiber by a femtosecond Yb fiber laser to improve threefold the axial resolution of frequency domain second-harmonic optical coherence tomography (SH-OCT) to 12 μm. The acquisition time was shortened by more than 2 orders of magnitude compared to the time-domain SH-OCT. The system was applied to image biological tissue of fish scales, pig leg tendon, and rabbit eye sclera. Highly organized collagen fibrils can be visualized in the recorded images. Polarization dependence on the SH has been used to obtain polarization resolved images.

Evaluation of High-Resolution Melting Curve Analysis of Ligation-Mediated Real-Time PCR, a Rapid Method for Epidemiological Typing of ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter Species) Pathogens

PubMed Central

Ryberg, Anna; Billström, Hanna; Hällgren, Anita; Nilsson, Lennart E.; Marklund, Britt-Inger; Olsson-Liljequist, Barbro; Schön, Thomas

2014-01-01

A single-tube method, ligation-mediated real-time PCR high-resolution melt analysis (LMqPCR HRMA), was modified for the rapid typing of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. (ESKAPE) pathogens. A 97% agreement (60/62 isolates) was achieved in comparison to pulsed-field gel electrophoresis (PFGE) results, which indicates that LMqPCR HRMA is a rapid and accurate screening tool for monitoring nosocomial outbreaks. PMID:25232168

CINCH (confocal incoherent correlation holography) super resolution fluorescence microscopy based upon FINCH (Fresnel incoherent correlation holography).

PubMed

Siegel, Nisan; Storrie, Brian; Bruce, Marc; Brooker, Gary

2015-02-07

FINCH holographic fluorescence microscopy creates high resolution super-resolved images with enhanced depth of focus. The simple addition of a real-time Nipkow disk confocal image scanner in a conjugate plane of this incoherent holographic system is shown to reduce the depth of focus, and the combination of both techniques provides a simple way to enhance the axial resolution of FINCH in a combined method called "CINCH". An important feature of the combined system allows for the simultaneous real-time image capture of widefield and holographic images or confocal and confocal holographic images for ready comparison of each method on the exact same field of view. Additional GPU based complex deconvolution processing of the images further enhances resolution.

Downscaling Land Surface Temperature in an Urban Area: A Case Study for Hamburg, Germany

NASA Astrophysics Data System (ADS)

Bechtel, Benjamin; Zakšek, Klemen

2013-04-01

Land surface temperature (LST) is an important parameter for the urban radiation and heat balance and a boundary condition for the atmospheric urban heat island (UHI). The increase in urban surface temperatures compared to the surrounding area (surface urban heat island, SUHI) has been described and analysed with satellite-based measurements for several decades. Besides continuous progress in the development of new sensors, an operational monitoring is still severely limited by physical constraints regarding the spatial and temporal resolution of the satellite data. Essentially, two measurement concepts must be distinguished: Sensors on geostationary platforms have high temporal (several times per hour) and poor spatial resolution (~ 5 km) while those on low earth orbiters have high spatial (~ 100-1000 m) resolution and a long return period (one day to several weeks). To enable an observation with high temporal and spatial resolution, a downscaling scheme for LST from the Spinning Enhanced Visible Infra-Red Imager (SEVIRI) sensor onboard the geostationary meteorological Meteosat 9 to spatial resolutions between 100 and 1000 m was developed and tested for Hamburg in this case study. Therefore, various predictor sets (including parameters derived from multi-temporal thermal data, NDVI, and morphological parameters) were tested. The relationship between predictors and LST was empirically calibrated in the low resolution domain and then transferred to the high resolution domain. The downscaling was validated with LST data from the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) for the same time. Aggregated parameters from multi-temporal thermal data (in particular annual cycle parameters and principal components) proved particularly suitable. The results for the highest resolution of 100 m showed a high explained variance (R² = 0.71) and relatively low root mean square errors (RMSE = 2.2 K). Larger predictor sets resulted in higher errors, because they tended to overfit. As expected the results were better for coarser spatial resolutions (R² = 0.80, RMSE = 1.8 K for 500 m). These results are similar or slightly better than in previous studies, although we are not aware of any study with a comparably large downscaling factor. A considerable percentage of the error is systematic due to the different viewing geometry of the sensors (the high resolution LST was overestimated about 1.3 K). The study shows that downscaling of SEVIRI LST is possible up to a resolution of 100 m for urban areas and that multi-temporal thermal data are particularly suitable as predictors.

Ultra-long high-sensitivity Φ-OTDR for high spatial resolution intrusion detection of pipelines.

PubMed

Peng, Fei; Wu, Han; Jia, Xin-Hong; Rao, Yun-Jiang; Wang, Zi-Nan; Peng, Zheng-Pu

2014-06-02

An ultra-long phase-sensitive optical time domain reflectometry (Φ-OTDR) that can achieve high-sensitivity intrusion detection over 131.5km fiber with high spatial resolution of 8m is presented, which is the longest Φ-OTDR reported to date, to the best of our knowledge. It is found that the combination of distributed Raman amplification with heterodyne detection can extend the sensing distance and enhances the sensitivity substantially, leading to the realization of ultra-long Φ-OTDR with high sensitivity and spatial resolution. Furthermore, the feasibility of applying such an ultra-long Φ-OTDR to pipeline security monitoring is demonstrated and the features of intrusion signal can be extracted with improved SNR by using the wavelet detrending/denoising method proposed.

Coherence Conversion for Optimized Resolution in Optical Measurements - Example of Femtosecond Time Resolution Using the Transverse Coherence of 100-Picosecond X-Rays

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adams, Bernhard W.

2015-01-01

A way is proposed to obtain a femtosecond time resolution over a picosecond range in x-ray spectroscopic measurements where the light source and the detector are much slower than that. It is based on the invariance of the modulus of the Fourier transform to object translations. The method geometrically correlates time in the sample with x-ray amplitudes over a spatial coordinate, and then takes the optical Fourier transform through far-field diffraction. Thus, explicitly time-invariant intensities that encode the time evolution of the sample can be measured with a slow detector. This corresponds to a phase-space transformation that converts the transversemore » coherence to become effective in the longitudinal direction. Because synchrotron-radiation sources have highly anisotropic coherence properties with about $10^5$ longitudinal electromagnetic-field modes at 1 eV bandwidth, but only tens to hundreds transverse modes, coherence conversion can drastically improve the time resolution. Reconstruction of the femtosecond time evolution in the sample from the Fourier intensities is subject to a phase ambiguity that is well-known in crystallography. However, a way is presented to resolve it that is not available in that discipline. Finally, data from a demonstration experiment are presented. The same concept can be used to obtain attosecond time resolution with an x-ray free-electron laser.« less

Variability along the Atlantic water pathway in the forced Norwegian Earth System Model

NASA Astrophysics Data System (ADS)

Langehaug, H. R.; Sandø, A. B.; Årthun, M.; Ilıcak, M.

2018-03-01

The growing attention on mechanisms that can provide predictability on interannual-to-decadal time scales, makes it necessary to identify how well climate models represent such mechanisms. In this study we use a high (0.25° horizontal grid) and a medium (1°) resolution version of a forced global ocean-sea ice model, utilising the Norwegian Earth System Model, to assess the impact of increased ocean resolution. Our target is the simulation of temperature and salinity anomalies along the pathway of warm Atlantic water in the subpolar North Atlantic and the Nordic Seas. Although the high resolution version has larger biases in general at the ocean surface, the poleward propagation of thermohaline anomalies is better resolved in this version, i.e., the time for an anomaly to travel northward is more similar to observation based estimates. The extent of these anomalies can be rather large in both model versions, as also seen in observations, e.g., stretching from Scotland to northern Norway. The easternmost branch into the Nordic and Barents Seas, carrying warm Atlantic water, is also improved by higher resolution, both in terms of mean heat transport and variability in thermohaline properties. A more detailed assessment of the link between the North Atlantic Ocean circulation and the thermohaline anomalies at the entrance of the Nordic Seas reveals that the high resolution is more consistent with mechanisms that are previously published. This suggests better dynamics and variability in the subpolar region and the Nordic Seas in the high resolution compared to the medium resolution. This is most likely due a better representation of the mean circulation in the studied region when using higher resolution. As the poleward propagation of ocean heat anomalies is considered to be a key source of climate predictability, we recommend that similar methodology presented herein should be performed on coupled climate models that are used for climate prediction.

T-2 in Coherent Optics: Collision, Dephasing Time, or Reciprocal Linewidth.

ERIC Educational Resources Information Center

Nettel, Stephen J.; Lempicki, Alexander

1979-01-01

Discusses how the frequency domain (line widths) and time domain (coherent optical transients) are related to the concept of transverse relaxation time in the study of high resolution optical spectroscopy. (HM)

Structural Characterisation of Acetogenins from Annona muricata by Supercritical Fluid Chromatography Coupled to High-Resolution Tandem Mass Spectrometry.

PubMed

Laboureur, Laurent; Bonneau, Natacha; Champy, Pierre; Brunelle, Alain; Touboul, David

2017-11-01

Acetogenins are plant polyketides known to be cytotoxic and proposed as antitumor candidates. They are also suspected to be alimentary neurotoxins. Their occurrence as complex mixtures renders their dereplication and structural identification difficult using liquid chromatography coupled to tandem mass spectrometry and efforts are required to improve the methodology. To develop a supercritical fluid chromatography (SFC) high-resolution tandem mass spectrometry method, involving lithium post-column cationisation, for the structural characterisation of Annonaceous acetogenins in crude extracts. The seeds of Annona muricata L. were extracted with methanol. Supercritical fluid chromatography of the extract, using a 2-ethylpyridine stationary phase column, was monitored using a high-resolution quadrupole time-of-flight mass spectrometer. Lithium iodide was added post-column in the make-up solvent. For comparison, the same extract was analysed using high-pressure liquid chromatography coupled to the same mass spectrometer, with a column based on solid core particles. Sensitivity was similar for both HPLC and SFC approaches. Retention behaviour and fragmentation pathways of three different isomer groups are described. A previously unknown group of acetogenins was also evidenced for the first time. The use of SFC-MS/MS allows the reduction of the time of analysis, of environmental impact and an increase in the chromatographic resolution, compared to liquid chromatography. This new methodology enlightened a new group of acetogenins, isomers of montanacin-D. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

Solving phase appearance/disappearance two-phase flow problems with high resolution staggered grid and fully implicit schemes by the Jacobian-free Newton–Krylov Method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zou, Ling; Zhao, Haihua; Zhang, Hongbin

2016-04-01

The phase appearance/disappearance issue presents serious numerical challenges in two-phase flow simulations. Many existing reactor safety analysis codes use different kinds of treatments for the phase appearance/disappearance problem. However, to our best knowledge, there are no fully satisfactory solutions. Additionally, the majority of the existing reactor system analysis codes were developed using low-order numerical schemes in both space and time. In many situations, it is desirable to use high-resolution spatial discretization and fully implicit time integration schemes to reduce numerical errors. In this work, we adapted a high-resolution spatial discretization scheme on staggered grid mesh and fully implicit time integrationmore » methods (such as BDF1 and BDF2) to solve the two-phase flow problems. The discretized nonlinear system was solved by the Jacobian-free Newton Krylov (JFNK) method, which does not require the derivation and implementation of analytical Jacobian matrix. These methods were tested with a few two-phase flow problems with phase appearance/disappearance phenomena considered, such as a linear advection problem, an oscillating manometer problem, and a sedimentation problem. The JFNK method demonstrated extremely robust and stable behaviors in solving the two-phase flow problems with phase appearance/disappearance. No special treatments such as water level tracking or void fraction limiting were used. High-resolution spatial discretization and second- order fully implicit method also demonstrated their capabilities in significantly reducing numerical errors.« less

Reference-free, high-resolution measurement method of timing jitter spectra of optical frequency combs

PubMed Central

Kwon, Dohyeon; Jeon, Chan-Gi; Shin, Junho; Heo, Myoung-Sun; Park, Sang Eon; Song, Youjian; Kim, Jungwon

2017-01-01

Timing jitter is one of the most important properties of femtosecond mode-locked lasers and optical frequency combs. Accurate measurement of timing jitter power spectral density (PSD) is a critical prerequisite for optimizing overall noise performance and further advancing comb applications both in the time and frequency domains. Commonly used jitter measurement methods require a reference mode-locked laser with timing jitter similar to or lower than that of the laser-under-test, which is a demanding requirement for many laser laboratories, and/or have limited measurement resolution. Here we show a high-resolution and reference-source-free measurement method of timing jitter spectra of optical frequency combs using an optical fibre delay line and optical carrier interference. The demonstrated method works well for both mode-locked oscillators and supercontinua, with 2 × 10−9 fs2/Hz (equivalent to −174 dBc/Hz at 10-GHz carrier frequency) measurement noise floor. The demonstrated method can serve as a simple and powerful characterization tool for timing jitter PSDs of various comb sources including mode-locked oscillators, supercontinua and recently emerging Kerr-frequency combs; the jitter measurement results enabled by our method will provide new insights for understanding and optimizing timing noise in such comb sources. PMID:28102352

Atomic-resolution transmission electron microscopy of electron beam–sensitive crystalline materials

NASA Astrophysics Data System (ADS)

Zhang, Daliang; Zhu, Yihan; Liu, Lingmei; Ying, Xiangrong; Hsiung, Chia-En; Sougrat, Rachid; Li, Kun; Han, Yu

2018-02-01

High-resolution imaging of electron beam–sensitive materials is one of the most difficult applications of transmission electron microscopy (TEM). The challenges are manifold, including the acquisition of images with extremely low beam doses, the time-constrained search for crystal zone axes, the precise image alignment, and the accurate determination of the defocus value. We develop a suite of methods to fulfill these requirements and acquire atomic-resolution TEM images of several metal organic frameworks that are generally recognized as highly sensitive to electron beams. The high image resolution allows us to identify individual metal atomic columns, various types of surface termination, and benzene rings in the organic linkers. We also apply our methods to other electron beam–sensitive materials, including the organic-inorganic hybrid perovskite CH3NH3PbBr3.