Race to the Top. District of Columbia Report. Year 2: School Year 2011-2012. [State-Specific Summary Report

ERIC Educational Resources Information Center

US Department of Education, 2013

2013-01-01

This State-specific summary report serves as an assessment of the District of Columbia's Year 2 Race to the Top implementation, highlighting successes and accomplishments, identifying challenges, and providing lessons learned from implementation from approximately September 2011 through September 2012. Despite the delays, the Office of the State…

Race to the Top. Ohio Report. Year 2: School Year 2011-2012. [State-Specific Summary Report

ERIC Educational Resources Information Center

US Department of Education, 2013

2013-01-01

This State-specific summary report serves as an assessment of Ohio's Year 2 Race to the Top implementation, highlighting successes and accomplishments, identifying challenges, and providing lessons learned from implementation from approximately September 2011 through September 2012. During Year 2, Ohio built on its Year 1 successes. In its…

Race to the Top. Rhode Island Report. Year 1: School Year 2010-2011. [State-Specific Summary Report

ERIC Educational Resources Information Center

US Department of Education, 2012

2012-01-01

This State-specific summary report serves as an assessment of Rhode Island's Year 1 Race to the Top implementation, highlighting successes and accomplishments, identifying challenges, and providing lessons learned from implementation to date. According to the State, in Year 1, Rhode Island greatly increased statewide capacity to begin…

Race to the Top. District of Columbia Report. Year 4: School Year 2013-2014. [State-Specific Summary Report

ERIC Educational Resources Information Center

US Department of Education, 2015

2015-01-01

This State-specific summary report serves as an assessment of the District of Columbia's annual Race to the Top implementation. The Year 4 report for Phase 2 grantees highlights successes and accomplishments, identifies challenges, and provides lessons learned from implementation from approximately September 2013 through September 2014. Given that…

Race to the Top. Delaware Report. Year 1: School Year 2010-2011. [State-Specific Summary Report

ERIC Educational Resources Information Center

US Department of Education, 2012

2012-01-01

This State-specific summary report serves as an assessment of Delaware's Year 1 Race to the Top implementation, highlighting successes and accomplishments, identifying challenges, and providing lessons learned from implementation to date. Delaware created new structures at the State level to support both State and LEA (local education agency) Race…

Race to the Top. North Carolina. Year 1: School Year 2010-2011. [State-Specific Summary Report

ERIC Educational Resources Information Center

US Department of Education, 2012

2012-01-01

This State-specific summary report serves as an assessment of North Carolina's Year 1 Race to the Top implementation, highlighting successes and accomplishments, identifying challenges, and providing lessons learned from implementation to date. Delaware created new structures at the State level to support both State and LEA (local education…

Race to the Top. Tennessee Report. Year 4: School Year 2013-2014. [State-Specific Summary Report

ERIC Educational Resources Information Center

US Department of Education, 2015

2015-01-01

The State-specific summary report serves as an assessment of Tennessee's annual Race to the Top implementation. The Year 4 report for Phase 2 grantees highlights successes and accomplishments, identifies challenges, and provides lessons learned from implementation from approximately September 2013 through September 2014. Given that Delaware and…

Race to the Top. Rhode Island Report. Year 3: School Year 2012-2013. [State-Specific Summary Report

ERIC Educational Resources Information Center

US Department of Education, 2014

2014-01-01

This State-specific summary report serves as an assessment of Rhode Island's Year 3 Race to the Top implementation, highlighting successes and accomplishments, identifying challenges, and providing lessons learned from implementation from approximately September 2012 through September 2013. In Year 3, many initiatives that were in the development…

Race to the Top. North Carolina Report. Year 4: School Year 2013-2014. [State-Specific Summary Report

ERIC Educational Resources Information Center

US Department of Education, 2015

2015-01-01

This State-specific summary report serves as an assessment of North Carolina's annual Race to the Top implementation. The Year 4 report for Phase 2 grantees highlights successes and accomplishments, identifies challenges, and provides lessons learned from implementation from approximately September 2013 through September 2014. In year 4, North…

Race to the Top. Delaware Report. Year 4: School Year 2013-2014. [State-Specific Summary Report

ERIC Educational Resources Information Center

US Department of Education, 2015

2015-01-01

The State-specific summary report serves as an assessment of Delaware's annual Race to the Top implementation. The Year 4 report for Phase 2 grantees highlights successes and accomplishments, identifies challenges, and provides lessons learned from implementation from approximately September 2013 through September 2014. Given that Delaware and…

Race to the Top. New York Report. Year 1: School Year 2010-2011. [State-Specific Summary Report

ERIC Educational Resources Information Center

US Department of Education, 2012

2012-01-01

This State-specific summary report serves as an assessment of New York's Year 1 Race to the Top implementation, highlighting successes and accomplishments, identifying challenges, and providing lessons learned from implementation to date. New York significantly increased its capacity to provide support to its local educational agencies (LEAs). At…

Race to the Top. Delaware Report. Year 3: School Year 2012-2013. [State-Specific Summary Report

ERIC Educational Resources Information Center

US Department of Education, 2014

2014-01-01

The State-specific summary report serves as an assessment of Delaware's annual Race to the Top implementation. The Year 3 report for Phase 1 and 2 grantees highlights successes and accomplishments, identifies challenges, and provides lessons learned from implementation from approximately September 2012 through September 2013. Delaware made…

Race to the Top. North Carolina Report. Year 3: School Year 2012-2013. [State-Specific Summary Report

ERIC Educational Resources Information Center

US Department of Education, 2014

2014-01-01

This State-specific summary report serves as an assessment of North Carolina's annual Race to the Top implementation. The Year 3 report for Phase 1 and 2 grantees highlights successes and accomplishments, identifies challenges, and provides lessons learned from implementation from approximately September 2012 through September 2013. In Year 3,…

Race to the Top. New York Report. Year 3: School Year 2012-2013. [State-Specific Summary Report

ERIC Educational Resources Information Center

US Department of Education, 2014

2014-01-01

This State-specific summary report serves as an assessment of the New York's annual Race to the Top implementation. The Year 3 report for Phase 1 and 2 grantees highlights successes and accomplishments, identifies challenges, and provides lessons learned from implementation from approximately September 2012 through September 2013. In Year 3, the…

Race to the Top. District of Columbia Report. Year 3: School Year 2012-2013. [State-Specific Summary Report

ERIC Educational Resources Information Center

US Department of Education, 2014

2014-01-01

This State-specific summary report serves as an assessment of the District of Columbia's annual Race to the Top implementation. The Year 3 report for Phase 1 and 2 grantees highlights successes and accomplishments, identifies challenges, and provides lessons learned from implementation from approximately September 2012 through September 2013. In…

Race to the Top. Hawaii Report. Year 3: School Year 2012-2013. [State-Specific Summary Report

ERIC Educational Resources Information Center

US Department of Education, 2014

2014-01-01

This State-specific summary report serves as an assessment of Hawaii's Year 3 Race to the Top implementation. The Year 3 report for Phase 1 and 2 grantees highlights successes and accomplishments, identifies challenges, and provides lessons learned from implementation from approximately September 2012 through September 2013; the Year 2 report for…

Race to the Top. Ohio. State-Reported APR: Year One

ERIC Educational Resources Information Center

US Department of Education, 2012

2012-01-01

This paper describes Ohio's progress in implementing a comprehensive and coherent approach to education reform from the time of application through June 30, 2011. The sections presented in this report highlight key accomplishments made by Ohio to implement a comprehensive and coherent approach to education reform over the reporting period in the…

A top-down approach in control engineering third-level teaching: The case of hydrogen-generation

NASA Astrophysics Data System (ADS)

Setiawan, Eko; Habibi, M. Afnan; Fall, Cheikh; Hodaka, Ichijo

2017-09-01

This paper presents a top-down approach in control engineering third-level teaching. The paper shows the control engineering solution for the issue of practical implementation in order to motivate students. The proposed strategy only focuses on one technique of control engineering to lead student correctly. The proposed teaching steps are 1) defining the problem, 2) listing of acquired knowledge or required skill, 3) selecting of one control engineering technique, 4) arrangement the order of teaching: problem introduction, implementation of control engineering technique, explanation of system block diagram, model derivation, controller design, and 5) enrichment knowledge by the other control techniques. The approach presented highlights hardware implementation and the use of software simulation as a self-learning tool for students.

Highlights of Total Quality Management in the Department of Defense: Lessons Learned, Quality Measurements and Innovative Practices

DTIC Science & Technology

1991-09-26

Quality Management (TQM) through both quantitative and qualitative analyses. Interviews were conducted with top executives from ten exemplar organizations within the Department of Defense (DOD). Survey questionnaires on perceptions of quality practices were administered to a sample of 102 representing members of the executive steering committees at the same organizations. Research identifies lessons learned by top executives during TQM implementation, discusses measures of organization-wide quality management , specifies evaluation mechanisms to

Race to the Top. Maryland. State-Reported APR: Year One

ERIC Educational Resources Information Center

US Department of Education, 2012

2012-01-01

This paper describes Maryland's progress in implementing a comprehensive and coherent approach to education reform from the time of application through June 30, 2011. In particular, this report highlights key accomplishments over the reporting period in the four reform areas: standards and assessments, data systems to support instruction, great…

Closing the Gap: A Report on the Wingspread Conference "Beyond the Standards Horse Race: Implementation, Assessment, and Accountability--the Keys to Improving Student Achievement" (Racine, Wisconsin, November 2-4, 1999). Special Report.

ERIC Educational Resources Information Center

Duggan, Terri, Ed.; Holmes, Madelyn, Ed.

This report highlights results from the 1999 Wingspread Conference on improving student achievement, a gathering of educators, leaders, and policymakers that opened a dialogue about barriers to full implementation of high standards for all students. Participants discussed five papers that examined these issues from top to bottom--from the…

Race to the Top. Hawaii. State-Reported APR: Year One

ERIC Educational Resources Information Center

US Department of Education, 2012

2012-01-01

This paper describes Hawaii's progress in implementing a comprehensive and coherent approach to education reform from the time of application through June 30, 2011. In particular, it highlights key accomplishments over the reporting period in the four reform areas: standards and assessments, data systems to support instruction, great teachers and…

Race to the Top. Rhode Island. State-Reported APR: Year One

ERIC Educational Resources Information Center

US Department of Education, 2012

2012-01-01

This paper describes Rhode Island's progress in implementing a comprehensive and coherent approach to education reform from the time of application through June 30, 2011. In particular, this report highlights key accomplishments over the reporting period in the four reform areas: standards and assessments, data systems to support instruction,…

Race to the Top. New York. State-Reported APR: Year One

ERIC Educational Resources Information Center

US Department of Education, 2012

2012-01-01

This paper describes New York's progress in implementing a comprehensive and coherent approach to education reform from the time of application through June 30, 2011. In particular, this report highlights key accomplishments over the reporting period in the four reform areas: standards and assessments, data systems to support instruction, great…

Teacher Preparation in Ethiopia: A Critical Analysis of Reforms

ERIC Educational Resources Information Center

Semela, Tesfaye

2014-01-01

The purpose of this article is to provide a more comprehensive picture of teacher preparation in Ethiopia on top of a closer scrutiny of current teacher education reforms. In particular, it presents teacher education within the context of policy implementation over the last six decades by highlighting key reforms and how these reforms impacted the…

Implementation of School Uniform Policy and the Violation of Students' Human Rights in Schools

ERIC Educational Resources Information Center

Mahlangu, Vimbi Petrus

2017-01-01

The paper highlights the violations of students' human rights in schools. The problem is the incident that took place at a school in Pretoria in 2016 where Black girls protested against the School's Code of Conduct relating to hairstyle. Qualitative approach was used to collect information through a literature review and desk-top research methods.…

ARM Climate Research Facility Quarterly Value-Added Product Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sivaraman, C.

The purpose of this report is to provide a concise status update for Value-Added Products (VAPs) implemented by the Atmospheric Radiation Measurement (ARM) Climate Research Facility. The report is divided into the following sections: (1) new VAPs for which development has begun; (2) progress on existing VAPs; (3) future VAPs that have been recently approved; (4) other work that leads to a VAP; (5) top requested VAPs from the ARM Data Archive; and (6) a summary of VAP and data releases to production and evaluation. New information is highlighted in blue text. New information about processed data by the developermore » is highlighted in red text. The upcoming milestones and dates are highlighted in green.« less

Knowledge-Based Integrated Information Systems Engineering: Highlights and Bibliography. Volume 1.

DTIC Science & Technology

1987-12-01

of database technology, 0 communication technology and expert systems technology. , Organizational issues cover the process of making controlled... process of linking strategic goals, technical issues , and organizational aspects can be depicted as shown in Figure 2.2. At the top level, strategic...an integrated information system design and implementation in a short period of time [4]. 2.2.2 Emphasis on Process It was mentioned in Section 1.3

Highlights of a Report on Staffing and Organization of Top-Management Headquarters in the Department of Defense

DTIC Science & Technology

1976-01-01

isionmak ing, —th- role of the service secretaries, and —changing workload. GAO recomends that the Secretary of Defense grcduaily implement a system to...clarify Office of the Secretary of Defense decision points in service program review and evaluation, and strongly tr.dorse the role of the service...i n —itarn —r",m\\t .->-—-.i. • ., •— —_:——^... . --.,„, . OSD SUGGESTIONS FOR CONSOLIDAVION I each o indcpe percen indepe conduc

From strategy to action: how top managers' support increases middle managers' commitment to innovation implementation in health care organizations.

PubMed

Birken, Sarah A; Lee, Shoou-Yih Daniel; Weiner, Bryan J; Chin, Marshall H; Chiu, Michael; Schaefer, Cynthia T

2015-01-01

Evidence suggests that top managers' support influences middle managers' commitment to innovation implementation. What remains unclear is how top managers' support influences middle managers' commitment. Results may be used to improve dismal rates of innovation implementation. We used a mixed-method sequential design. We surveyed (n = 120) and interviewed (n = 16) middle managers implementing an innovation intended to reduce health disparities in 120 U.S. health centers to assess whether top managers' support directly influences middle managers' commitment; by allocating implementation policies and practices; or by moderating the influence of implementation policies and practices on middle managers' commitment. For quantitative analyses, multivariable regression assessed direct and moderated effects; a mediation model assessed mediating effects. We used template analysis to assess qualitative data. We found support for each hypothesized relationship: Results suggest that top managers increase middle managers' commitment by directly conveying to middle managers that innovation implementation is an organizational priority (β = 0.37, p = .09); allocating implementation policies and practices including performance reviews, human resources, training, and funding (bootstrapped estimate for performance reviews = 0.09; 95% confidence interval [0.03, 0.17]); and encouraging middle managers to leverage performance reviews and human resources to achieve innovation implementation. Top managers can demonstrate their support directly by conveying to middle managers that an initiative is an organizational priority, allocating implementation policies and practices such as human resources and funding to facilitate innovation implementation, and convincing middle managers that innovation implementation is possible using available implementation policies and practices. Middle managers may maximize the influence of top managers' support on their commitment by communicating with top managers about what kind of support would be most effective in increasing their commitment to innovation implementation.

From Strategy to Action: How Top Managers’ Support Increases Middle Managers’ Commitment to Innovation Implementation in Healthcare Organizations

PubMed Central

Lee, Shoou-Yih Daniel; Weiner, Bryan J.; Chin, Marshall H.; Chiu, Michael; Schaefer, Cynthia T.

2014-01-01

Background Evidence suggests that top managers’ support influences middle managers’ commitment to innovation implementation. What remains unclear is how top managers’ support influences middle managers’ commitment. Results may be used to improve dismal rates of innovation implementation. Methods We used a mixed-method sequential design. We surveyed (n = 120) and interviewed (n = 16) middle managers implementing an innovation intended to reduce health disparities in 120 US health centers to assess whether top managers’ support influences middle managers’ commitment directly, by allocating implementation policies and practices, or by moderating the influence of implementation policies and practices on middle managers’ commitment. For quantitative analyses, multivariable regression assessed direct and moderated effects; a mediation model assessed mediating effects. We used template analysis to assess qualitative data. Findings We found support for each hypothesized relationship: Results suggest that top managers increase middle managers’ commitment by directly conveying to middle managers that innovation implementation is an organizational priority (β = 0.37, p = 0.09); allocating implementation policies and practices including performance reviews, human resources, training, and funding (bootstrapped estimate for performance reviews = 0.09; 95 percent CI: 0.03, 0.17); and encouraging middle managers to leverage performance reviews and human resources to achieve innovation implementation. Practice Implications Top managers can demonstrate their support by directly conveying to middle managers that an initiative is an organizational priority, allocating implementation policies and practices such as human resources and funding to facilitate innovation implementation, and convincing middle managers that innovation implementation is possible using available implementation policies and practices. Middle managers may maximize the influence of top managers’ support on their commitment by communicating with top managers about what kind of support would be most effective in increasing their commitment to innovation implementation. PMID:24566252

Evaluating Postural Control and Ankle Laxity Between Taping and High-Top Cleats in High School Football Players.

PubMed

Pizac, Douglas A; Swanik, Charles B; Glutting, Joseph J; Kaminski, Thomas W

2018-03-01

Lateral ankle sprains are the most common injuries in high school sports. While ankle taping is a preferred method of external prophylactic support, its restrictive properties decline during exercise. The Under Armour ® Highlight cleat is marketed on the premise that it provides added support without the need for additional ankle taping. To determine if differences in ankle joint laxity and postural control exist between football players wearing the Under Armour ® Highlight cleat (Under Armour Inc, Baltimore, MD) as compared to a low/mid-top cleat with ankle tape. Crossover trial. Athletic training room and football practice field sideline. 32 interscholastic football players (15.8 ± 1.0 y; 178.9 ± 7.4 cm; 87.1 ± 21.4 kg). Ankle laxity was assessed using an instrumented ankle arthrometer (Blue Bay Research Inc, Milton, FL), while postural control testing was performed on the Tekscan MobileMat™ Balanced Error Scoring System (BESS; South Boston, MA). The 2 treatments included Under Armour ® Highlight cleats and a low/mid-top cleat with ankle tape applied to the nondominant ankle only. Measurements were taken before and immediately after practice. The independent variable was treatment (Highlight vs low/mid-top cleat with ankle tape). Dependent variables included ankle arthrometry measures of anterior displacement (mm), inversion/eversion rotation (deg), and the modified BESS error scores. A linear mixed-effects model was used for analysis. The low/mid-top cleat with tape condition had significantly higher inversion range-of-motion (ROM) and inversion/eversion rotation postexercise when compared to the Highlight cleat (P < 0.05). The results of this study provide some evidence that the Under Armour ® Highlight cleat restricts ankle ROM following a training session better than the taped low/mid-top cleat. Further study is warranted to determine if this high-top style of football cleat can reduce the incidence of ankle sprains and how it might compare to spat taping.

Understanding influential factors on implementing green supply chain management practices: An interpretive structural modelling analysis.

PubMed

Agi, Maher A N; Nishant, Rohit

2017-03-01

In this study, we establish a set of 19 influential factors on the implementation of Green Supply Chain Management (GSCM) practices and analyse the interaction between these factors and their effect on the implementation of GSCM practices using the Interpretive Structural Modelling (ISM) method and the "Matrice d'Impacts Croisés Multiplication Appliquée à un Classement" (MICMAC) analysis on data compiled from interviews with supply chain (SC) executives based in the Gulf countries (Middle East region). The study reveals a strong influence and driving power of the nature of the relationships between SC partners on the implementation of GSCM practices. We especially found that dependence, trust, and durability of the relationship with SC partners have a very high influence. In addition, the size of the company, the top management commitment, the implementation of quality management and the employees training and education exert a critical influence on the implementation of GSCM practices. Contextual elements such as the industry sector and region and their effect on the prominence of specific factors are also highlighted through our study. Finally, implications for research and practice are discussed. Copyright © 2016 Elsevier Ltd. All rights reserved.

Does evaluative pressure make you less or more distractible? Role of top-down attentional control over response selection.

PubMed

Normand, Alice; Bouquet, Cédric A; Croizet, Jean-Claude

2014-06-01

People's ability to resist cognitive distraction is crucial in many situations. The present research examines individuals' resistance to attentional distraction under conditions of evaluative pressure. In a series of 4 studies, participants had to complete various attentional tasks while believing their intelligence was or was not under the scrutiny of an experimenter. Using a spatial cuing paradigm, Studies 1 through 3 demonstrated that feeling evaluated led participants to implement stronger feature-based attentional control, which resulted in more (or less) distraction when irrelevant information matched (did not match) the searched-for target. Study 4 ruled out the possibility that the above effects were due to voluntary shifts of attention and demonstrated that the control settings implemented under evaluative pressure resulted in stronger goal-contingent response priming. Thus, the way individuals relate to the task-the performance context in which they are-induces strong attentional selection biases. Altogether, the present findings highlight an overlooked form of top-down modulation of attention based on performance self-relevance. Implications for both the current models of attentional control and the current hypotheses on the impact of evaluative pressure on cognition, as well as the consequences for more complex performances, are discussed. PsycINFO Database Record (c) 2014 APA, all rights reserved.

Evaluating the effectiveness of implementing quality management practices in the medical industry.

PubMed

Yeh, T-M; Lai, H-P

2015-01-01

To discuss the effectiveness of 30 quality management practices (QMP) including Strategic Management, Balanced ScoreCard, Knowledge Management, and Total Quality Management in the medical industry. A V-shaped performance evaluation matrix is applied to identify the top ten practices that are important but not easy to use or implement. Quality Function Deployment (QFD) is then utilized to find key factors to improve the implementation of the top ten tools. The questionnaires were sent to the nursing staff and administrators in a hospital through e-mail and posts. A total of 250 copies were distributed and 217 copies were valid. The importance, easiness, and achievement (i.e., implementation level) of 30 quality management practices were used. Key factors for QMP implementation were sequenced in order of importance as top management involvement, inter-department communication and coordination, teamwork, hospital-wide participation, education and training, consultant professionalism, continuous internal auditing, computerized process, and incentive compensation. Top management can implement the V-shaped performance matrix to determine whether quality management practices need improvement and if so, utilize QFD to find the key factors for improvement.

Editorial highlighting and highly cited papers

NASA Astrophysics Data System (ADS)

Antonoyiannakis, Manolis

Editorial highlighting-the process whereby journal editors select, at the time of publication, a small subset of papers that are ostensibly of higher quality, importance or interest-is by now a widespread practice among major scientific journal publishers. Depending on the venue, and the extent to which editorial resources are invested in the process, highlighted papers appear as News & Views, Research Highlights, Perspectives, Editors' Choice, IOP Select, Editors' Summary, Spotlight on Optics, Editors' Picks, Viewpoints, Synopses, Editors' Suggestions, etc. Here, we look at the relation between highlighted papers and highly influential papers, which we define at two levels: having received enough citations to be among the (i) top few percent of their journal, and (ii) top 1% of all physics papers. Using multiple linear regression and multilevel regression modeling we examine the parameters associated with highly influential papers. We briefly comment on cause and effect relationships between citedness and highlighting of papers.

Measurements of top quark properties at CDF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kraan, Aafke C.; /Pennsylvania U.

The top quark with its mass of about 172 GeV/c{sup 2} is the most massive fundamental particle observed by experiment. In this talk they highlight the most recent measurements of several top quark properties performed with the CDF detector based on data samples corresponding to integrated luminosities up to 1 fb{sup -1}. These results include a search for top quark pair production via new massive resonances, measurements of the helicity of the W boson from top-quark decay, and a direct limit on the lifetime of the top quark.

Green Power Partnership Top Partner Rankings

EPA Pesticide Factsheets

EPA's Green Power Partnership is a voluntary program designed to reduce the environmental impact of electricity generation by promoting renewable energy. Top Partner Rankings highlight the annual green power use of leading Green Power Partners.

Stimulus- and goal-driven control of eye movements: action videogame players are faster but not better.

PubMed

Heimler, Benedetta; Pavani, Francesco; Donk, Mieke; van Zoest, Wieske

2014-11-01

Action videogame players (AVGPs) have been shown to outperform nongamers (NVGPs) in covert visual attention tasks. These advantages have been attributed to improved top-down control in this population. The time course of visual selection, which permits researchers to highlight when top-down strategies start to control performance, has rarely been investigated in AVGPs. Here, we addressed specifically this issue through an oculomotor additional-singleton paradigm. Participants were instructed to make a saccadic eye movement to a unique orientation singleton. The target was presented among homogeneous nontargets and one additional orientation singleton that was more, equally, or less salient than the target. Saliency was manipulated in the color dimension. Our results showed similar patterns of performance for both AVGPs and NVGPs: Fast-initiated saccades were saliency-driven, whereas later-initiated saccades were more goal-driven. However, although AVGPs were faster than NVGPs, they were also less accurate. Importantly, a multinomial model applied to the data revealed comparable underlying saliency-driven and goal-driven functions for the two groups. Taken together, the observed differences in performance are compatible with the presence of a lower decision bound for releasing saccades in AVGPs than in NVGPs, in the context of comparable temporal interplay between the underlying attentional mechanisms. In sum, the present findings show that in both AVGPs and NVGPs, the implementation of top-down control in visual selection takes time to come about, and they argue against the idea of a general enhancement of top-down control in AVGPs.

Modeling the leadership attributes of top management in green innovation implementation

NASA Astrophysics Data System (ADS)

Ishak, Noormaizatul Akmar; Ramli, Mohammad Fadzli

2015-05-01

The implementation of green innovation in the companies is the interest of the governments all over the world. This has been the main focus of the Copenhagen Protocol and Kyoto Protocol that require all governments to preserve the nature through green initiatives. This paper proposes a mathematical model on the leadership attributes of the top management in ensuring green innovation implementation in their companies' strategies to reduce operational cost. With green innovation implementation in the Government-Linked Companies (GLCs), we identify the leadership attributes are tied up to the leadership style of the top managers in the companies. Through this model we have proved that green type leadership always contributes better in cost saving, therefore it is a more efficient leadership attribute for the GLCs especially.

Clinical course in women undergoing termination of pregnancy within the legal time limit in French-speaking Switzerland.

PubMed

Perrin, Eliane; Berthoud, Marianne; Pott, Murielle; Toledo Vera, Anna G; Perrenoud, David; Bianchi-Demicheli, Francesco

2011-10-19

In 2002, Swiss citizens voted to accept new laws legalising the termination of pregnancy (TOP) up to 12th week of pregnancy. As a result the cantons formulated rules of implementation. Health institutions then had to modify their procedures and practices. One of the objectives of these changes was to simplify the clinical course for women who decide to terminate a pregnancy. Have the various health institutions in French-speaking Switzerland attained this goal? Are there differences between cantons? Are there any other differences, and if so, which ones? Comparative study of cantonal rules of implementation. Study by questionnaire of what happened to 281 women having undergone a TOP in French-speaking Switzerland. Quantitative and qualitative method. The comparative legal study of the six cantonal rules of implementation showed differences between cantons. The clinical course for women are defined by four quantifiable facts: 1) the number of days delay between the woman's decision (first step) and TOP; 2) the number of appointments attended before TOP; 3) the method of TOP; 4) the cost of TOP. On average, the waiting time was 12 days and the number of appointments was 3. The average cost of TOP was 1360 CHF. The differences, sometimes quite large, are explained by the size of the institutions (large university hospitals; average-sized, non-university hospitals; private doctors' offices). The cantonal rules of implementation and the size of the health care institutions play an important role in these courses for women in French-speaking Switzerland.

A-Train Observations of Deep Convective Storm Tops

NASA Technical Reports Server (NTRS)

Setvak, Martin; Bedka, Kristopher; Lindsey, Daniel T.; Sokol, Alois; Charvat, Zdenek; Stastka, Jindrich; Wang, Pao K.

2013-01-01

The paper highlights simultaneous observations of tops of deep convective clouds from several space-borne instruments including the Moderate Resolution Imaging Spectroradiometer (MODIS) of the Aqua satellite, Cloud Profiling Radar (CPR) of the CloudSat satellite, and Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP) flown on the CALIPSO satellite. These satellites share very close orbits, thus together with several other satellites they are referred to as the "A-Train" constellation. Though the primary responsibility of these satellites and their instrumentation is much broader than observations of fine-scale processes atop convective storms, in this study we document how data from the A-Train can contribute to a better understanding and interpretation of various storm-top features, such as overshooting tops, cold-U/V and cold ring features with their coupled embedded warm areas, above anvil ice plumes and jumping cirrus. The relationships between MODIS multi-spectral brightness temperature difference (BTD) fields and cloud top signatures observed by the CPR and CALIOP are also examined in detail to highlight the variability in BTD signals across convective storm events.

Sustainable diversity. This year's Top 25 minority Executives in Healthcare highlights leadership diversity, but some question the true level of inclusion.

PubMed

Kirchheimer, Barbara

2008-04-07

While more minority candidates are moving into top healthcare positions, many challenges remain. One is to address true inclusion, an expert says. And Andrea Price, left, selected as one of Modem Healthcare's Top 25 Minority Executives in Healthcare, says minorities can have a hard time rising to top positions. "The industry needs to understand that everyone doesn't start off on the same playing field," she says.

A modified estimation distribution algorithm based on extreme elitism.

PubMed

Gao, Shujun; de Silva, Clarence W

2016-12-01

An existing estimation distribution algorithm (EDA) with univariate marginal Gaussian model was improved by designing and incorporating an extreme elitism selection method. This selection method highlighted the effect of a few top best solutions in the evolution and advanced EDA to form a primary evolution direction and obtain a fast convergence rate. Simultaneously, this selection can also keep the population diversity to make EDA avoid premature convergence. Then the modified EDA was tested by means of benchmark low-dimensional and high-dimensional optimization problems to illustrate the gains in using this extreme elitism selection. Besides, no-free-lunch theorem was implemented in the analysis of the effect of this new selection on EDAs. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Net Survey: "Top Ten Mistakes" in Academic Web Design.

ERIC Educational Resources Information Center

Petrik, Paula

2000-01-01

Highlights the top ten mistakes in academic Web design: (1) bloated graphics; (2) scaling images; (3) dense text; (4) lack of contrast; (5) font size; (6) looping animations; (7) courseware authoring software; (8) scrolling/long pages; (9) excessive download; and (10) the nothing site. Includes resources. (CMK)

Designing Inter-Organizational Networks to Implement Education Reform: An Analysis of State Race to the Top Applications

ERIC Educational Resources Information Center

Russell, Jennifer Lin; Meredith, Julie; Childs, Joshua; Stein, Mary Kay; Prine, Deanna Weber

2015-01-01

This study sought to understand the opportunities and challenges associated with the implementation of state designed Race to the Top (RttT) funded reform networks. Drawing on a conceptual framework developed from the networked governance literature, we analyzed the 12 state RttT grantees' applications. Our analysis revealed that states designed…

"We're Going to Make Lemonade out of Lemons": Urban Principals, Emotion, and Race to the Top Implementation

ERIC Educational Resources Information Center

Wieczorek, Douglas; Theoharis, George

2015-01-01

This study reports on four urban middle- and high school principals' emotionally shaped sense making of Race to the Top policies and their ability to balance the competing demands of teachers' emotional needs with the charge to implement mandated, accountability-driven, instructional, and evaluation changes in their schools. Despite the pressure…

Race to the Top. Hawaii Report. Year 4: School Year 2013-2014. [State-Specific Summary Report

ERIC Educational Resources Information Center

US Department of Education, 2015

2015-01-01

This State-specific summary report serves as an assessment of Hawaii's Year 4 Race to the Top implementation. Hawaii made tremendous progress over the course of the grant period in implementing its Strategic Plan and six priority strategies and creating an aligned organization focused on increasing student outcomes. Among some of the other…

Autism treatment survey: services received by children with autism spectrum disorders in public school classrooms.

PubMed

Hess, Kristen L; Morrier, Michael J; Heflin, L Juane; Ivey, Michelle L

2008-05-01

The Autism Treatment Survey was developed to identify strategies used in education of children with autism spectrum disorders (ASD) in Georgia. Respondents of the web-based survey included a representative sample of 185 teachers across the state, reporting on 226 children with ASD in grades preschool-12th. The top five strategies being used in Georgia (Gentle Teaching, sensory integration, cognitive behavioral modification, assistive technology, and Social Stories) are recognized as lacking a scientific basis for implementation. Analysis revealed the choice of strategies varied by grade level and classroom type (e.g., general education, special education). Results highlight clear implications for preservice and inservice educator training, and the need for continued research to document evidence-based strategy use in public schools for students with ASD.

What is Bottom-Up and What is Top-Down in Predictive Coding?

PubMed Central

Rauss, Karsten; Pourtois, Gilles

2013-01-01

Everyone knows what bottom-up is, and how it is different from top-down. At least one is tempted to think so, given that both terms are ubiquitously used, but only rarely defined in the psychology and neuroscience literature. In this review, we highlight the problems and limitations of our current understanding of bottom-up and top-down processes, and we propose a reformulation of this distinction in terms of predictive coding. PMID:23730295

A Top-down versus a Bottom-up Hidden-variables Description of the Stern-Gerlach Experiment

NASA Astrophysics Data System (ADS)

Arsenijević, M.; Jeknić-Dugić, J.; Dugić, M.

We employ the Stern-Gerlach experiment to highlight the basics of a minimalist, non-interpretational top-down approach to quantum foundations. Certain benefits of the "quantum structural studies" (QSS) highlightedhere are detected and discussed. While the top-down approach can be described without making any reference to the fundamental structure of a closed system, the hidden variables (HV) theory á la Bohm proves to be more subtle than it is typically regarded.

Evaluating the sub-national fidelity of national Initiatives in decentralized health systems: Integrated Primary Health Care Governance in Nigeria.

PubMed

Eboreime, Ejemai Amaize; Abimbola, Seye; Obi, Felix Abrahams; Ebirim, Obinna; Olubajo, Olalekan; Eyles, John; Nxumalo, Nonhlanhla Lynette; Mambulu, Faith Nankasa

2017-03-21

Policy making, translation and implementation in politically and administratively decentralized systems can be challenging. Beyond the mere sub-national acceptance of national initiatives, adherence to policy implementation processes is often poor, particularly in low and middle-income countries. In this study, we explore the implementation fidelity of integrated PHC governance policy in Nigeria's decentralized governance system and its implications on closing implementation gaps with respect to other top-down health policies and initiatives. Having engaged policy makers, we identified 9 core components of the policy (Governance, Legislation, Minimum Service Package, Repositioning, Systems Development, Operational Guidelines, Human Resources, Funding Structure, and Office Establishment). We evaluated the level and pattern of implementation at state level as compared to the national guidelines using a scorecard approach. Contrary to national government's assessment of level of compliance, we found that sub-national governments exercised significant discretion with respect to the implementation of core components of the policy. Whereas 35 and 32% of states fully met national criteria for the structural domains of "Office Establishment" and Legislation" respectively, no state was fully compliant to "Human Resource Management" and "Funding" requirements, which are more indicative of functionality. The pattern of implementation suggests that, rather than implementing to improve outcomes, state governments may be more interested in executing low hanging fruits in order to access national incentives. Our study highlights the importance of evaluating implementation fidelity in providing evidence of implementation gaps towards improving policy execution, particularly in decentralized health systems. This approach will help national policy makers identify more effective ways of supporting lower tiers of governance towards improvement of health systems and outcomes.

Integrating Top-down and Bottom-up Cybersecurity Guidance using XML

PubMed Central

Lubell, Joshua

2016-01-01

This paper describes a markup-based approach for synthesizing disparate information sources and discusses a software implementation of the approach. The implementation makes it easier for people to use two complementary, but differently structured, guidance specifications together: the (top-down) Cybersecurity Framework and the (bottom-up) National Institute of Standards and Technology Special Publication 800-53 security control catalog. An example scenario demonstrates how the software implementation can help a security professional select the appropriate safeguards for restricting unauthorized access to an Industrial Control System. The implementation and example show the benefits of this approach and suggest its potential application to disciplines other than cybersecurity. PMID:27795810

The Top 100 Bachelor's Degree Conferred

ERIC Educational Resources Information Center

Borden, Victor M. H.

2010-01-01

Each year in the Top 100 series, researchers highlight the institutions that confer the most degrees to students of color. In this edition, they focus on the most prevalent degree conferred: the bachelor's degree. Among the types of colleges and universities that they examine--those that have Title IV status (recognized by the U.S. Department of…

Top 10 Lessons Learned from Electronic Medical Record Implementation in a Large Academic Medical Center.

PubMed

Rizer, Milisa K; Kaufman, Beth; Sieck, Cynthia J; Hefner, Jennifer L; McAlearney, Ann Scheck

2015-01-01

Electronic medical record (EMR) implementation efforts face many challenges, including individual and organizational barriers and concerns about loss of productivity during the process. These issues may be particularly complex in large and diverse settings with multiple specialties providing inpatient and outpatient care. This case report provides an example of a successful EMR implementation that emphasizes the importance of flexibility and adaptability on the part of the implementation team. It also presents the top 10 lessons learned from this EMR implementation in a large midwestern academic medical center. Included are five overarching lessons related to leadership, initial approach, training, support, and optimization as well as five lessons related to the EMR system itself that are particularly important elements of a successful implementation.

Top 10 Lessons Learned from Electronic Medical Record Implementation in a Large Academic Medical Center

PubMed Central

Rizer, Milisa K.; Kaufman, Beth; Sieck, Cynthia J.; Hefner, Jennifer L.; McAlearney, Ann Scheck

2015-01-01

Electronic medical record (EMR) implementation efforts face many challenges, including individual and organizational barriers and concerns about loss of productivity during the process. These issues may be particularly complex in large and diverse settings with multiple specialties providing inpatient and outpatient care. This case report provides an example of a successful EMR implementation that emphasizes the importance of flexibility and adaptability on the part of the implementation team. It also presents the top 10 lessons learned from this EMR implementation in a large midwestern academic medical center. Included are five overarching lessons related to leadership, initial approach, training, support, and optimization as well as five lessons related to the EMR system itself that are particularly important elements of a successful implementation. PMID:26396558

Race to the Top - Early Learning Challenge: 2014 Annual Performance Report. Wisconsin

ERIC Educational Resources Information Center

Race to the Top - Early Learning Challenge, 2015

2015-01-01

This Race to the Top - Early Learning Challenge (RTT-ELC) annual performance report for the year 2014 describes Wisconsin's accomplishments, lessons learned, challenges, and strategies Wisconsin will implement to address those challenges. During the second year of the Race to the Top - Early Learning Challenge (RTT-ELC) in Wisconsin, there have…

A methodology for Manufacturing Execution Systems (MES) implementation

NASA Astrophysics Data System (ADS)

Govindaraju, Rajesri; Putra, Krisna

2016-02-01

Manufacturing execution system is information systems (IS) application that bridges the gap between IS at the top level, namely enterprise resource planning (ERP), and IS at the lower levels, namely the automation systems. MES provides a media for optimizing the manufacturing process as a whole in a real time basis. By the use of MES in combination with the implementation of ERP and other automation systems, a manufacturing company is expected to have high competitiveness. In implementing MES, functional integration -making all the components of the manufacturing system able to work well together, is the most difficult challenge. For this, there has been an industry standard that specifies the sub-systems of a manufacturing execution systems and defines the boundaries between ERP systems, MES, and other automation systems. The standard is known as ISA-95. Although the advantages from the use of MES have been stated in some studies, not much research being done on how to implement MES effectively. The purpose of this study is to develop a methodology describing how MES implementation project should be managed, utilising the support of ISA- 95 reference model in the system development process. A proposed methodology was developed based on a general IS development methodology. The developed methodology were then revisited based on the understanding about the specific charateristics of MES implementation project found in an Indonesian steel manufacturing company implementation case. The case study highlighted the importance of applying an effective requirement elicitation method during innitial system assessment process, managing system interfaces and labor division in the design process, and performing a pilot deployment before putting the whole system into operation.

A top-down design methodology and its implementation for VCSEL-based optical links design

NASA Astrophysics Data System (ADS)

Li, Jiguang; Cao, Mingcui; Cai, Zilong

2005-01-01

In order to find the optimal design for a given specification of an optical communication link, an integrated simulation of electronic, optoelectronic, and optical components of a complete system is required. It is very important to be able to simulate at both system level and detailed model level. This kind of model is feasible due to the high potential of Verilog-AMS language. In this paper, we propose an effective top-down design methodology and employ it in the development of a complete VCSEL-based optical links simulation. The principle of top-down methodology is that the development would proceed from the system to device level. To design a hierarchical model for VCSEL based optical links, the design framework is organized in three levels of hierarchy. The models are developed, and implemented in Verilog-AMS. Therefore, the model parameters are fitted to measured data. A sample transient simulation demonstrates the functioning of our implementation. Suggestions for future directions in top-down methodology used for optoelectronic systems technology are also presented.

Strategies for Success

ERIC Educational Resources Information Center

Tedrick, Lou; Sumsion, Zach; Smith, Mary; Cutshall, Charlie

2012-01-01

"Training" magazine taps 2012 Training Top 125 winners and Top 10 Hall of Famers to provide their learning and development best practices in each issue. This article looks at strategies to foster technology innovation and implementation and onboarding.

Top 10 Research Questions Related to Physical Activity in Preschool Children

ERIC Educational Resources Information Center

Pate, Russell R.; O'Neill, Jennifer R.; Brown, William H.; McIver, Kerry L.; Howie, Erin K.; Dowda, Marsha

2013-01-01

The purpose of this article was to highlight important research needs related to physical activity in 3-to 5-year-old children. We identified research needs in 3 major categories: health effects, patterns of physical activity, and interventions and policies. The top research needs include identifying the health effects of physical activity, the…

An Evaluation of Top Notch Fundamentals B: A Four Phase Study

ERIC Educational Resources Information Center

Ahmadi, Marzie

2016-01-01

Textbooks play an important role in educational contexts especially in EFL contexts their role are more highlighted. Textbook evaluation in any type, predictive or retrospective, is a necessary part of curriculum design and in this sense is a worthwhile means of conducting research. Recently, Top Notch series have become widely used in Iranian…

Barcode identification for transfusion safety.

PubMed

Murphy, M F; Kay, J D S

2004-09-01

Errors related to blood transfusion in hospitals may produce catastrophic consequences. This review addresses potential solutions to prevent patient misidentification including the use of new technology, such as barcoding. A small number of studies using new technology for the transfusion process in hospitals have shown promising results in preventing errors. The studies demonstrated improved transfusion safety and staff preference for new technology such as bedside handheld scanners to carry out pretransfusion bedside checking. They also highlighted the need for considerable efforts in the training of staff in the new procedures before their successful implementation. Improvements in hospital transfusion safety are a top priority for transfusion medicine, and will depend on a combined approach including a better understanding of the causes of errors, a reduction in the complexity of routine procedures taking advantage of new technology, improved staff training, and regular monitoring of practice. The use of new technology to improve the safety of transfusion is very promising. Further development of the systems is needed to enable staff to carry out bedside transfusion procedures quickly and accurately, and to increase their functionality to justify the cost of their wider implementation.

One size fits all? An assessment tool for solid waste management at local and national levels

DOE Office of Scientific and Technical Information (OSTI.GOV)

Broitman, Dani, E-mail: danib@techunix.technion.ac.il; Ayalon, Ofira; Kan, Iddo

2012-10-15

Highlights: Black-Right-Pointing-Pointer Waste management schemes are generally implemented at national or regional level. Black-Right-Pointing-Pointer Local conditions characteristics and constraints are often neglected. Black-Right-Pointing-Pointer We developed an economic model able to compare multi-level waste management options. Black-Right-Pointing-Pointer A detailed test case with real economic data and a best-fit scenario is described. Black-Right-Pointing-Pointer Most efficient schemes combine clear National directives with local level flexibility. - Abstract: As environmental awareness rises, integrated solid waste management (WM) schemes are increasingly being implemented all over the world. The different WM schemes usually address issues such as landfilling restrictions (mainly due to methane emissions and competingmore » land use), packaging directives and compulsory recycling goals. These schemes are, in general, designed at a national or regional level, whereas local conditions and constraints are sometimes neglected. When national WM top-down policies, in addition to setting goals, also dictate the methods by which they are to be achieved, local authorities lose their freedom to optimize their operational WM schemes according to their specific characteristics. There are a myriad of implementation options at the local level, and by carrying out a bottom-up approach the overall national WM system will be optimal on economic and environmental scales. This paper presents a model for optimizing waste strategies at a local level and evaluates this effect at a national level. This is achieved by using a waste assessment model which enables us to compare both the economic viability of several WM options at the local (single municipal authority) level, and aggregated results for regional or national levels. A test case based on various WM approaches in Israel (several implementations of mixed and separated waste) shows that local characteristics significantly influence WM costs, and therefore the optimal scheme is one under which each local authority is able to implement its best-fitting mechanism, given that national guidelines are kept. The main result is that strict national/regional WM policies may be less efficient, unless some type of local flexibility is implemented. Our model is designed both for top-down and bottom-up assessment, and can be easily adapted for a wide range of WM option comparisons at different levels.« less

Factors Influencing Implementation of OHSAS 18001 in Indian Construction Organizations: Interpretive Structural Modeling Approach

PubMed Central

Rajaprasad, Sunku Venkata Siva; Chalapathi, Pasupulati Venkata

2015-01-01

Background Construction activity has made considerable breakthroughs in the past two decades on the back of increases in development activities, government policies, and public demand. At the same time, occupational health and safety issues have become a major concern to construction organizations. The unsatisfactory safety performance of the construction industry has always been highlighted since the safety management system is neglected area and not implemented systematically in Indian construction organizations. Due to a lack of enforcement of the applicable legislation, most of the construction organizations are forced to opt for the implementation of Occupational Health Safety Assessment Series (OHSAS) 18001 to improve safety performance. Methods In order to better understand factors influencing the implementation of OHSAS 18001, an interpretive structural modeling approach has been applied and the factors have been classified using matrice d'impacts croises-multiplication appliqué a un classement (MICMAC) analysis. The study proposes the underlying theoretical framework to identify factors and to help management of Indian construction organizations to understand the interaction among factors influencing in implementation of OHSAS 18001. Results Safety culture, continual improvement, morale of employees, and safety training have been identified as dependent variables. Safety performance, sustainable construction, and conducive working environment have been identified as linkage variables. Management commitment and safety policy have been identified as the driver variables. Conclusion Management commitment has the maximum driving power and the most influential factor is safety policy, which states clearly the commitment of top management towards occupational safety and health. PMID:26929828

Investigating and Learning Lessons from Early Experiences of Implementing ePrescribing Systems into NHS Hospitals: A Questionnaire Study

PubMed Central

Cresswell, Kathrin; Coleman, Jamie; Slee, Ann; Williams, Robin; Sheikh, Aziz

2013-01-01

Background ePrescribing systems have significant potential to improve the safety and efficiency of healthcare, but they need to be carefully selected and implemented to maximise benefits. Implementations in English hospitals are in the early stages and there is a lack of standards guiding the procurement, functional specifications, and expected benefits. We sought to provide an updated overview of the current picture in relation to implementation of ePrescribing systems, explore existing strategies, and identify early lessons learned. Methods A descriptive questionnaire-based study, which included closed and free text questions and involved both quantitative and qualitative analysis of the data generated. Results We obtained responses from 85 of 108 NHS staff (78.7% response rate). At least 6% (n = 10) of the 168 English NHS Trusts have already implemented ePrescribing systems, 2% (n = 4) have no plans of implementing, and 34% (n = 55) are planning to implement with intended rapid implementation timelines driven by high expectations surrounding improved safety and efficiency of care. The majority are unclear as to which system to choose, but integration with existing systems and sophisticated decision support functionality are important decisive factors. Participants highlighted the need for increased guidance in relation to implementation strategy, system choice and standards, as well as the need for top-level management support to adequately resource the project. Although some early benefits were reported by hospitals that had already implemented, the hoped for benefits relating to improved efficiency and cost-savings remain elusive due to a lack of system maturity. Conclusions Whilst few have begun implementation, there is considerable interest in ePrescribing systems with ambitious timelines amongst those hospitals that are planning implementations. In order to ensure maximum chances of realising benefits, there is a need for increased guidance in relation to implementation strategy, system choice and standards, as well as increased financial resources to fund local activities. PMID:23335961

Report on the formal specification and partial verification of the VIPER microprocessor

NASA Technical Reports Server (NTRS)

Brock, Bishop; Hunt, Warren A., Jr.

1991-01-01

The VIPER microprocessor chip is partitioned into four levels of abstractions. At the highest level, VIPER is described with decreasingly abstract sets of functions in LCF-LSM. At the lowest level are the gate-level models in proprietary CAD languages. The block-level and gate-level specifications are also given in the ELLA simulation language. Among VIPER's deficiencies are the fact that there is no notion of external events in the top-level specification, and it is impossible to use the top-level specifications to prove abstract properties of programs running on VIPER computers. There is no complete proof that the gate-level specifications implement the top-level specifications. Cohn's proof that the major-state machine correctly implements the top-level specifications has no formal connection with any of the other proof attempts. None of the latter address resetting the machine, memory timeout, forced error, or single step modes.

Views of implementation approaches by top managers in health service organizations.

PubMed

Nutt, P C

1996-01-01

This study examined how top managers view the prospects of success and resistance when using four implementation approaches in participative and control cultures that foster climates more or less conducive to change. An accommodation approach was viewed as having the best prospect of success and of lowering resistance in a participative culture. Bargaining and incentive approaches were thought to have successful and low resistance outcomes, which were just below those of accommodation, in a control type of culture. A persuasion approach was thought to be the least effective implementation approach in a control-oriented culture. These preferences differ from prescriptions found in the implementation literature. Assuming that preferences influence behavior, implementation success could be improved if managers selected an implementation approach according to the demands of the situation. More research is needed to appreciate fully the rationale that lies behind the preferences uncovered in this research.

Top-down, bottom-up, and around the jungle gym: a social exchange and networks approach to engaging afterschool programs in implementing evidence-based practices.

PubMed

Smith, Emilie Phillips; Wise, Eileen; Rosen, Howard; Rosen, Alison; Childs, Sharon; McManus, Margaret

2014-06-01

This paper uses concepts from social networks and social exchange theories to describe the implementation of evidence-based practices in afterschool programs. The members of the LEGACY Together Afterschool Project team have been involved in conducting collaborative research to migrate a behavioral strategy that has been documented to reduce disruptive behaviors in classroom settings to a new setting-that of afterschool programs. We adapted the Paxis Institute's version of the Good Behavior Game to afterschool settings which differ from in-school settings, including more fluid attendance, multiple age groupings, diverse activities that may take place simultaneously, and differences in staff training and experience (Barrish et al. in J Appl Behav Anal 2(2):119-124, 1969; Embry et al. in The Pax Good Behavior Game. Hazelden, Center City, 2003; Hynes et al. in J Child Serv 4(3):4-20, 2009; Kellam et al. in Drug Alcohol Depend 95:S5-S28, 2008; Tingstrom et al. in Behav Modif 30(2):225-253, 2006). This paper presents the experiences of the three adult groups involved in the implementation process who give first-person accounts of implementation: (1) university-based scientist-practitioners, (2) community partners who trained and provided technical assistance/coaching, and (3) an afterschool program administrator. We introduce here the AIMS model used to frame the implementation process conceptualized by this town-gown collaborative team. AIMS builds upon previous work in implementation science using four phases in which the three collaborators have overlapping roles: approach/engagement, implementation, monitoring, and sustainability. Within all four phases principles of Social Exchange Theory and Social Network Theory are highlighted.

The opinions and experiences of Irish obstetric and gynaecology trainee doctors in relation to abortion services in Ireland.

PubMed

Aitken, Kara; Patek, Paul; Murphy, Mark E

2017-11-01

The provision of abortion services in the Republic of Ireland is legally restricted. Recent legislation that has been implemented allows for abortion if there is a real and substantial risk to the woman's life, but in general Irish women must travel abroad for abortion services. The aims of this study were to investigate the clinical experiences of Irish obstetric non-consultant hospital doctors (NCHDs) that work in this environment and to assess their attitudes towards termination of pregnancy (ToP). We conducted an online cross-sectional descriptive survey of 184 Irish obstetric NCHDs. Quantitate and qualitative analysis was performed. There was a 28% response rate. 88% of respondents thought that ToP should be permitted for fatal fetal abnormality if the parents choose, 96% if the woman's health is severely affected and 86% in cases of rape and incest. Over 90% of respondents believed a woman's health suffers because of the need to travel abroad to undergo a ToP. Physical, psychological and social reasons were explored. The research also highlights that obstetric trainees are actively involved in the provision of preabortion and postabortion care. The clinical experiences and opinions of the respondents suggest that the current legal availability of abortion in Ireland is insufficient to guide best clinical practice and does not represent the views of those that provide obstetric care. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

The association between implementation strategy use and the uptake of hepatitis C treatment in a national sample.

PubMed

Rogal, Shari S; Yakovchenko, Vera; Waltz, Thomas J; Powell, Byron J; Kirchner, JoAnn E; Proctor, Enola K; Gonzalez, Rachel; Park, Angela; Ross, David; Morgan, Timothy R; Chartier, Maggie; Chinman, Matthew J

2017-05-11

Hepatitis C virus (HCV) is a common and highly morbid illness. New medications that have much higher cure rates have become the new evidence-based practice in the field. Understanding the implementation of these new medications nationally provides an opportunity to advance the understanding of the role of implementation strategies in clinical outcomes on a large scale. The Expert Recommendations for Implementing Change (ERIC) study defined discrete implementation strategies and clustered these strategies into groups. The present evaluation assessed the use of these strategies and clusters in the context of HCV treatment across the US Department of Veterans Affairs (VA), Veterans Health Administration, the largest provider of HCV care nationally. A 73-item survey was developed and sent to all VA sites treating HCV via electronic survey, to assess whether or not a site used each ERIC-defined implementation strategy related to employing the new HCV medication in 2014. VA national data regarding the number of Veterans starting on the new HCV medications at each site were collected. The associations between treatment starts and number and type of implementation strategies were assessed. A total of 80 (62%) sites responded. Respondents endorsed an average of 25 ± 14 strategies. The number of treatment starts was positively correlated with the total number of strategies endorsed (r = 0.43, p < 0.001). Quartile of treatment starts was significantly associated with the number of strategies endorsed (p < 0.01), with the top quartile endorsing a median of 33 strategies, compared to 15 strategies in the lowest quartile. There were significant differences in the types of strategies endorsed by sites in the highest and lowest quartiles of treatment starts. Four of the 10 top strategies for sites in the top quartile had significant correlations with treatment starts compared to only 1 of the 10 top strategies in the bottom quartile sites. Overall, only 3 of the top 15 most frequently used strategies were associated with treatment. These results suggest that sites that used a greater number of implementation strategies were able to deliver more evidence-based treatment in HCV. The current assessment also demonstrates the feasibility of electronic self-reporting to evaluate ERIC strategies on a large scale. These results provide initial evidence for the clinical relevance of the ERIC strategies in a real-world implementation setting on a large scale. This is an initial step in identifying which strategies are associated with the uptake of evidence-based practices in nationwide healthcare systems.

Top Down Implementation Plan for system performance test software

NASA Technical Reports Server (NTRS)

Jacobson, G. N.; Spinak, A.

1982-01-01

The top down implementation plan used for the development of system performance test software during the Mark IV-A era is described. The plan is based upon the identification of the hierarchical relationship of the individual elements of the software design, the development of a sequence of functionally oriented demonstrable steps, the allocation of subroutines to the specific step where they are first required, and objective status reporting. The results are: determination of milestones, improved managerial visibility, better project control, and a successful software development.

Top ten challenges when interfacing a laboratory information system to an electronic health record: Experience at a large academic medical center.

PubMed

Petrides, Athena K; Tanasijevic, Milenko J; Goonan, Ellen M; Landman, Adam B; Kantartjis, Michalis; Bates, David W; Melanson, Stacy E F

2017-10-01

Recent U.S. government regulations incentivize implementation of an electronic health record (EHR) with computerized order entry and structured results display. Many institutions have also chosen to interface their EHR to their laboratory information system (LIS). Reported long-term benefits include increased efficiency and improved quality and safety. In order to successfully implement an interfaced EHR-LIS, institutions must plan years in advance and anticipate the impact of an integrated system. It can be challenging to fully understand the technical, workflow and resource aspects and adequately prepare for a potentially protracted system implementation and the subsequent stabilization. We describe the top ten challenges that we encountered in our clinical laboratories following the implementation of an interfaced EHR-LIS and offer suggestions on how to overcome these challenges. This study was performed at a 777-bed, tertiary care center which recently implemented an interfaced EHR-LIS. Challenges were recorded during EHR-LIS implementation and stabilization and the authors describe the top ten. Our top ten challenges were selection and harmonization of test codes, detailed training for providers on test ordering, communication with EHR provider champions during the build process, fluid orders and collections, supporting specialized workflows, sufficient reports and metrics, increased volume of inpatient venipunctures, adequate resources during stabilization, unanticipated changes to laboratory workflow and ordering specimens for anatomic pathology. A few suggestions to overcome these challenges include regular meetings with clinical champions, advanced considerations of reports and metrics that will be needed, adequate training of laboratory staff on new workflows in the EHR and defining all tests including anatomic pathology in the LIS. EHR-LIS implementations have many challenges requiring institutions to adapt and develop new infrastructures. This article should be helpful to other institutions facing or undergoing a similar endeavor. Copyright © 2017 Elsevier B.V. All rights reserved.

Uncovering middle managers' role in healthcare innovation implementation

PubMed Central

2012-01-01

Background Middle managers have received little attention in extant health services research, yet they may have a key role in healthcare innovation implementation. The gap between evidence of effective care and practice may be attributed in part to poor healthcare innovation implementation. Investigating middle managers' role in healthcare innovation implementation may reveal an opportunity for improvement. In this paper, we present a theory of middle managers' role in healthcare innovation implementation to fill the gap in the literature and to stimulate research that empirically examines middle managers' influence on innovation implementation in healthcare organizations. Discussion Extant healthcare innovation implementation research has primarily focused on the roles of physicians and top managers. Largely overlooked is the role of middle managers. We suggest that middle managers influence healthcare innovation implementation by diffusing information, synthesizing information, mediating between strategy and day-to-day activities, and selling innovation implementation. Summary Teamwork designs have become popular in healthcare organizations. Because middle managers oversee these team initiatives, their potential to influence innovation implementation has grown. Future research should investigate middle managers' role in healthcare innovation implementation. Findings may aid top managers in leveraging middle managers' influence to improve the effectiveness of healthcare innovation implementation. PMID:22472001

Uncovering middle managers' role in healthcare innovation implementation.

PubMed

Birken, Sarah A; Lee, Shoou-Yih Daniel; Weiner, Bryan J

2012-04-03

Middle managers have received little attention in extant health services research, yet they may have a key role in healthcare innovation implementation. The gap between evidence of effective care and practice may be attributed in part to poor healthcare innovation implementation. Investigating middle managers' role in healthcare innovation implementation may reveal an opportunity for improvement. In this paper, we present a theory of middle managers' role in healthcare innovation implementation to fill the gap in the literature and to stimulate research that empirically examines middle managers' influence on innovation implementation in healthcare organizations. Extant healthcare innovation implementation research has primarily focused on the roles of physicians and top managers. Largely overlooked is the role of middle managers. We suggest that middle managers influence healthcare innovation implementation by diffusing information, synthesizing information, mediating between strategy and day-to-day activities, and selling innovation implementation. Teamwork designs have become popular in healthcare organizations. Because middle managers oversee these team initiatives, their potential to influence innovation implementation has grown. Future research should investigate middle managers' role in healthcare innovation implementation. Findings may aid top managers in leveraging middle managers' influence to improve the effectiveness of healthcare innovation implementation.

Frontal top-down signals increase coupling of auditory low-frequency oscillations to continuous speech in human listeners.

PubMed

Park, Hyojin; Ince, Robin A A; Schyns, Philippe G; Thut, Gregor; Gross, Joachim

2015-06-15

Humans show a remarkable ability to understand continuous speech even under adverse listening conditions. This ability critically relies on dynamically updated predictions of incoming sensory information, but exactly how top-down predictions improve speech processing is still unclear. Brain oscillations are a likely mechanism for these top-down predictions [1, 2]. Quasi-rhythmic components in speech are known to entrain low-frequency oscillations in auditory areas [3, 4], and this entrainment increases with intelligibility [5]. We hypothesize that top-down signals from frontal brain areas causally modulate the phase of brain oscillations in auditory cortex. We use magnetoencephalography (MEG) to monitor brain oscillations in 22 participants during continuous speech perception. We characterize prominent spectral components of speech-brain coupling in auditory cortex and use causal connectivity analysis (transfer entropy) to identify the top-down signals driving this coupling more strongly during intelligible speech than during unintelligible speech. We report three main findings. First, frontal and motor cortices significantly modulate the phase of speech-coupled low-frequency oscillations in auditory cortex, and this effect depends on intelligibility of speech. Second, top-down signals are significantly stronger for left auditory cortex than for right auditory cortex. Third, speech-auditory cortex coupling is enhanced as a function of stronger top-down signals. Together, our results suggest that low-frequency brain oscillations play a role in implementing predictive top-down control during continuous speech perception and that top-down control is largely directed at left auditory cortex. This suggests a close relationship between (left-lateralized) speech production areas and the implementation of top-down control in continuous speech perception. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Frontal Top-Down Signals Increase Coupling of Auditory Low-Frequency Oscillations to Continuous Speech in Human Listeners

PubMed Central

Park, Hyojin; Ince, Robin A.A.; Schyns, Philippe G.; Thut, Gregor; Gross, Joachim

2015-01-01

Summary Humans show a remarkable ability to understand continuous speech even under adverse listening conditions. This ability critically relies on dynamically updated predictions of incoming sensory information, but exactly how top-down predictions improve speech processing is still unclear. Brain oscillations are a likely mechanism for these top-down predictions [1, 2]. Quasi-rhythmic components in speech are known to entrain low-frequency oscillations in auditory areas [3, 4], and this entrainment increases with intelligibility [5]. We hypothesize that top-down signals from frontal brain areas causally modulate the phase of brain oscillations in auditory cortex. We use magnetoencephalography (MEG) to monitor brain oscillations in 22 participants during continuous speech perception. We characterize prominent spectral components of speech-brain coupling in auditory cortex and use causal connectivity analysis (transfer entropy) to identify the top-down signals driving this coupling more strongly during intelligible speech than during unintelligible speech. We report three main findings. First, frontal and motor cortices significantly modulate the phase of speech-coupled low-frequency oscillations in auditory cortex, and this effect depends on intelligibility of speech. Second, top-down signals are significantly stronger for left auditory cortex than for right auditory cortex. Third, speech-auditory cortex coupling is enhanced as a function of stronger top-down signals. Together, our results suggest that low-frequency brain oscillations play a role in implementing predictive top-down control during continuous speech perception and that top-down control is largely directed at left auditory cortex. This suggests a close relationship between (left-lateralized) speech production areas and the implementation of top-down control in continuous speech perception. PMID:26028433

Research Priorities for Eight Areas of Adolescent Health in Low- and Middle-Income Countries.

PubMed

Nagata, Jason M; Ferguson, B Jane; Ross, David A

2016-07-01

To conduct an expert-led process for identifying research priorities for eight areas of adolescent health in low- and middle-income countries. Specific adolescent health areas included communicable diseases prevention and management, injuries and violence, mental health, noncommunicable diseases management, nutrition, physical activity, substance use, and health policy. We used a modified version of the Child Health and Nutrition Research Initiative methodology for reaching consensus on research priorities. In a three phase process, we (1) identified research and program experts with wide-ranging backgrounds and experiences from all geographic regions through systematic searches and key informants; (2) invited these experts to propose research questions related to descriptive epidemiology, interventions (discovery, development/testing, and delivery/implementation), and health policy/systems; and (3) asked the experts to prioritize the research questions based on five criteria: clarity, answerability, importance or impact, implementation, and equity. A total of 142 experts submitted 512 questions which were edited and reduced to 303 for scoring. Overall, the types of the top 10 research questions in each of the eight health areas included descriptive epidemiology (26%), interventions: discovery (11%), development/testing (25%), delivery (33%), and policy, health and social systems (5%). Across health areas, the top questions highlighted integration of health services, vulnerable populations, and different health platforms (such as primary care, schools, families/parents, and interactive media). Priority questions have been identified for research in eight key areas of adolescent health in low- and middle-income countries. These expert-generated questions may be used by donors, program managers, and researchers to prioritize and stimulate research in adolescent health. Copyright © 2016. Published by Elsevier Inc.

Experiences from First Top-Off Injection at the Stanford Synchrotron Radiation Lightsource

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bauer, J.M.; Liu, J.C.; Prinz, A.

2009-12-11

As the Stanford Synchrotron Radiation Lightsource (SSRL) of the SLAC National Accelerator Laboratory (SLAC) is moving toward Top-Off injection mode, SLAC's Radiation Protection Department is working with SSRL on minimizing the radiological hazards of this mode. One such hazard is radiation that is created inside the accelerator concrete enclosure by injected beam. Since during Top-Off injection the stoppers that would otherwise isolate the storage ring from the experimental area stay open, the stoppers no longer prevent such radiation from reaching the experimental area. The level of this stray radiation was measured in April 2008 during the first Top-Off injection tests.more » They revealed radiation dose rates of up to 18 microSv/h (1.8 millirem/h) outside the experimental hutches, significantly higher than our goal of 1 microSv/h (0.1 millirem/h). Non-optimal injection increased the measured dose rates by a factor two. Further tests in 2008 indicated that subsequent improvements by SSRL to the injection system have reduced the dose rates to acceptable levels. This presentation describes the studies performed before the Top-Off tests, the tests themselves and their major results (both under initial conditions and after improvements were implemented), and presents the controls being implemented for full and routine Top-Off injection.« less

[Cultivation strategy and path analysis on big brand Chinese medicine for small and medium-sized enterprises].

PubMed

Wang, Yong-Yan; Yang, Hong-Jun

2014-03-01

Small and medium-sized enterprises (SMEs) are important components in Chinese medicine industry. However, the lack of big brand is becoming an urgent problem which is critical to the survival of SMEs. This article discusses the concept and traits of Chinese medicine of big brand, from clinical, scientific and market value three aspects. Guided by market value, highlighting clinical value, aiming at the scientific value improvement of big brand cultivation, we put forward the key points in cultivation, aiming at obtaining branded Chinese medicine with widely recognized efficacy, good quality control system and mechanism well explained and meanwhile which can bring innovation improvement to theory of Chinese medicine. According to the characters of SMEs, we hold a view that to build multidisciplinary research union could be considered as basic path, and then, from top-level design, skill upgrading and application three stages to probe the implementation strategy.

Computer algorithms in the search for unrelated stem cell donors.

PubMed

Steiner, David

2012-01-01

Hematopoietic stem cell transplantation (HSCT) is a medical procedure in the field of hematology and oncology, most often performed for patients with certain cancers of the blood or bone marrow. A lot of patients have no suitable HLA-matched donor within their family, so physicians must activate a "donor search process" by interacting with national and international donor registries who will search their databases for adult unrelated donors or cord blood units (CBU). Information and communication technologies play a key role in the donor search process in donor registries both nationally and internationaly. One of the major challenges for donor registry computer systems is the development of a reliable search algorithm. This work discusses the top-down design of such algorithms and current practice. Based on our experience with systems used by several stem cell donor registries, we highlight typical pitfalls in the implementation of an algorithm and underlying data structure.

Improving clinician-carer communication for safer hospital care: a study of the 'TOP 5' strategy in patients with dementia.

PubMed

Luxford, Karen; Axam, Anne; Hasnip, Fiona; Dobrohotoff, John; Strudwick, Maureen; Reeve, Rebecca; Hou, Changhao; Viney, Rosalie

2015-06-01

To examine the impact of implementing a clinician-carer communication tool for hospitalized patients with dementia. Surveys were conducted with clinicians and carers about perceptions and experiences. Implementation process and costs were explored through surveys of local staff. Time series analysis was conducted on incident-reported falls, usage of non-regular anti-psychotics and one-to-one nursing. Twenty-one hospitals in Australia. Surveys were returned by 798 clinicians, 240 carers and 21 local liaison staff involved in implementation. Implementation of a communication tool over 12 months. The process of implementation was documented. Outcome measures included clinician and carer perceptions, safety indicators (incident-reported falls and usage of non-regular anti-psychotics), resource use and costs. Clinicians and carers reported high levels of acceptability and perceived benefits for patients. Clinicians rated confidence in caring for patients with dementia as being significantly higher after the introduction of TOP 5, (M = 2.93, SD = 0.65), than prior to TOP 5 (M = 2.74, SD = 0.75); F(1,712) = 11.21, P < 0.05. When analysed together, there was no change in incident-reported falls across all hospitals. At one hospital with a matched control ward, an average of 6.85 fewer falls incidents per month occurred in the intervention ward compared with the matched control ward (B = -6.85, P < 0.05). Our findings indicate that the use of a simple, low-cost communication strategy for patient care is associated with improvements in clinician and carer experience with potential implications for patient safety. Minimally, TOP 5 represents 'good practice' with a low risk of harm for patients. © The Author 2015. Published by Oxford University Press in association with the International Society for Quality in Health Care; all rights reserved.

Audience-contingent variation in action demonstrations for humans and computers.

PubMed

Herberg, Jonathan S; Saylor, Megan M; Ratanaswasd, Palis; Levin, Daniel T; Wilkes, D Mitchell

2008-09-01

People may exhibit two kinds of modifications when demonstrating action for others: modifications to facilitate bottom-up, or sensory-based processing; and modifications to facilitate top-down, or knowledge-based processing. The current study examined actors' production of such modifications in action demonstrations for audiences that differed in their capacity for intentional reasoning. Actors' demonstrations of complex actions for a non-anthropomorphic computer system and for people (adult and toddler) were compared. Evidence was found for greater highlighting of top-down modifications in the demonstrations for the human audiences versus the computer audience. Conversely, participants highlighted simple perceptual modifications for the computer audience, producing more punctuated and wider ranging motions. This study suggests that people consider differences in their audiences when demonstrating action. 2008 Cognitive Science Society, Inc.

Levels of the E2 interacting protein TopBP1 modulate papillomavirus maintenance stage replication

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kanginakudru, Sriramana, E-mail: skangina@iu.edu; DeSmet, Marsha, E-mail: mdesmet@iupui.edu; Thomas, Yanique, E-mail: ysthomas@umail.iu.edu

2015-04-15

The evolutionarily conserved DNA topoisomerase II beta-binding protein 1 (TopBP1) functions in DNA replication, DNA damage response, and cell survival. We analyzed the role of TopBP1 in human and bovine papillomavirus genome replication. Consistent with prior reports, TopBP1 co-localized in discrete nuclear foci and was in complex with papillomavirus E2 protein. Similar to E2, TopBP1 is recruited to the region of the viral origin of replication during G1/S and early S phase. TopBP1 knockdown increased, while over-expression decreased transient virus replication, without affecting cell cycle. Similarly, using cell lines harboring HPV-16 or HPV-31 genome, TopBP1 knockdown increased while over-expression reducedmore » viral copy number relative to genomic DNA. We propose a model in which TopBP1 serves dual roles in viral replication: it is essential for initiation of replication yet it restricts viral copy number. - Highlights: • Protein interaction study confirmed In-situ interaction between TopBP1 and E2. • TopBP1 present at papillomavirus ori in G1/S and early S phase of cell cycle. • TopBP1 knockdown increased, over-expression reduced virus replication. • TopBP1 protein level change did not influence cell survival or cell cycle. • TopBP1 displaced from papillomavirus ori after initiation of replication.« less

Analytics that Inform the University: Using Data You Already Have

ERIC Educational Resources Information Center

Dziuban, Charles; Moskal, Patsy; Cavanagh, Thomas; Watts, Andre

2012-01-01

The authors describe the University of Central Florida's top-down/bottom-up action analytics approach to using data to inform decision-making at the University of Central Florida. The top-down approach utilizes information about programs, modalities, and college implementation of Web initiatives. The bottom-up approach continuously monitors…

The Use of Assessment for Institutional Sensemaking by Top Administrative Officials

ERIC Educational Resources Information Center

Hegeman, Johnston Niven

2010-01-01

This study explored the relationship between the degree to which top administrators of four-year colleges and universities that have been effective in implementing and sustaining assessment view the use of assessment and seven components of institutional sensemaking at their institutions. The underlying premise is that outcomes assessment…

Race to the Top - Early Learning Challenge: 2015 Annual Performance Report. Maryland

ERIC Educational Resources Information Center

Race to the Top - Early Learning Challenge, 2016

2016-01-01

This Race to the Top - Early Learning Challenge (RTT-ELC) annual performance report for the year 2015 describes Maryland's accomplishments, lessons learned, challenges, and strategies Maryland will implement to address those challenges. Maryland's remarkable progress in increasing participation in their tiered quality rating and improvement…

Race to the Top - Early Learning Challenge: 2015 Annual Performance Report. Vermont

ERIC Educational Resources Information Center

Race to the Top - Early Learning Challenge, 2016

2016-01-01

This Race to the Top - Early Learning Challenge (RTT-ELC) annual performance report for the year 2015 describes Vermont's accomplishments, lessons learned, challenges, and strategies Vermont will implement to address those challenges. Vermont's remarkable progress in increasing participation in their tiered quality rating and improvement system,…

Race to the Top - Early Learning Challenge: 2015 Annual Performance Report. Pennsylvania

ERIC Educational Resources Information Center

Race to the Top - Early Learning Challenge, 2016

2016-01-01

This Race to the Top - Early Learning Challenge (RTT-ELC) annual performance report for the year 2015 describes Pennsylvania's accomplishments, lessons learned, challenges, and strategies Pennsylvania will implement to address those challenges. Pennsylvania's remarkable progress in increasing participation in their tiered quality rating and…

Race to the Top - Early Learning Challenge: 2015 Annual Performance Report. Minnesota

ERIC Educational Resources Information Center

Race to the Top - Early Learning Challenge, 2016

2016-01-01

This Race to the Top - Early Learning Challenge (RTT-ELC) annual performance report for the year 2015 describes Minnesota's accomplishments, lessons learned, challenges, and strategies Minnesota will implement to address those challenges. Minnesota's remarkable progress in increasing participation in their tiered quality rating and improvement…

How a "Top-Performing" Asian School System Formulates and Implements Policy: The Case of Singapore

ERIC Educational Resources Information Center

Tan, Cheng Yong; Dimmock, Clive

2014-01-01

This article analyses the paradox inherent in the "top-performing" yet tightly controlled Singapore education system. As government controls have increased in complexity, existing policymaking conceptual heuristics in accounting for centre-periphery relationships appear inadequate. It argues that more direct government control is being…

Replacement-ready? Succession planning tops health care administrators' priorities.

PubMed

Husting, P M; Alderman, M

2001-09-01

Nurses' increasing age coupled with health care's rapidly changing environment moves succession planning, originally only a business sector tool, to a top administrative priority. Through active support of your facility's executive leadership and a clear linkage to long range organization objectives, you can implement this progressive procedure.

Teacher Evaluation Initial Policy Implementation: Superintendent and Principal Perceptions

ERIC Educational Resources Information Center

Derrington, Mary Lynne

2014-01-01

This multi-site qualitative study examined the perspectives of K-12 superintendents and principals in four districts of a Southeastern state during the implementation of a new teacher evaluation system required by the Race to the Top federal grant. Specifically, these educators' viewpoints regarding this two-year implementation's impact are…

Managerial Receptivity and Implementation of Policies.

ERIC Educational Resources Information Center

Stevens, John M.; And Others

1980-01-01

Managerial receptivity to new policy, perceived emphasis by top level management, organizational size, work overload, perceptions of the importance of performance for promotion, and the manager's attitude toward change were important predictors for successful implementation. (Author)

Biospheric Monitoring and Ecological Forecasting using EOS/MODIS data, ecosystem modeling, planning and scheduling technologies

NASA Astrophysics Data System (ADS)

Nemani, R. R.; Votava, P.; Golden, K.; Hashimoto, H.; Jolly, M.; White, M.; Running, S.; Coughlan, J.

2003-12-01

The latest generation of NASA Earth Observing System satellites has brought a new dimension to continuous monitoring of the living part of the Earth System, the Biosphere. EOS data can now provide weekly global measures of vegetation productivity and ocean chlorophyll, and many related biophysical factors such as land cover changes or snowmelt rates. However, information with the highest economic value would be forecasting impending conditions of the biosphere that would allow advanced decision-making to mitigate dangers, or exploit positive trends. We have developed a software system called the Terrestrial Observation and Prediction System (TOPS) to facilitate rapid analysis of ecosystem states/functions by integrating EOS data with ecosystem models, surface weather observations and weather/climate forecasts. Land products from MODIS (Moderate Resolution Imaging Spectroradiometer) including land cover, albedo, snow, surface temperature, leaf area index are ingested into TOPS for parameterization of models and for verifying model outputs such as snow cover and vegetation phenology. TOPS is programmed to gather data from observing networks such as USDA soil moisture, AMERIFLUX, SNOWTEL to further enhance model predictions. Key technologies enabling TOPS implementation include the ability to understand and process heterogeneous-distributed data sets, automated planning and execution of ecosystem models, causation analysis for understanding model outputs. Current TOPS implementations at local (vineyard) to global scales (global net primary production) can be found at http://www.ntsg.umt.edu/tops.

CCR Magazines | Center for Cancer Research

Cancer.gov

The Center for Cancer Research (CCR) has two magazines, MILESTONES and LANDMARKS, that highlight our annual advances and top contributions to the understanding, detection, treatment and prevention of cancer over the years.

--No Title--

Science.gov Websites

mobile_icon{margin-right:5px;margin-left:8px}div#tools-main span i{margin-right:6px;float:left}div #tools-main i.icon-eere-arrow-header-link{margin:0 0 0 4px;vertical-align:center}div#tools-main div.highlight-box{margin-top:20px}div#tools-main div.highlight-box div{height:70px;width:33px;display:inline

Tailoring Enterprise Systems Engineering Policy for Project Scale and Complexity

NASA Technical Reports Server (NTRS)

Cox, Renee I.; Thomas, L. Dale

2014-01-01

Space systems are characterized by varying degrees of scale and complexity. Accordingly, cost-effective implementation of systems engineering also varies depending on scale and complexity. Recognizing that systems engineering and integration happen everywhere and at all levels of a given system and that the life cycle is an integrated process necessary to mature a design, the National Aeronautic and Space Administration's (NASA's) Marshall Space Flight Center (MSFC) has developed a suite of customized implementation approaches based on project scale and complexity. While it may be argued that a top-level system engineering process is common to and indeed desirable across an enterprise for all space systems, implementation of that top-level process and the associated products developed as a result differ from system to system. The implementation approaches used for developing a scientific instrument necessarily differ from those used for a space station. .

Role of Progesterone Receptor Isoforms in Regulation of Cell Adhesion and Apoptosis

DTIC Science & Technology

2002-06-01

repeatable) (figure 1 below). We used taxol to induce apoptosis instead of tumor necrosis factor (TNF) (as initially proposed in the grant) because...highlighted in red in Fig. 6A), monocyte chemotactic protein (MCP; open arrow in Fig. 6A and isolated in Fig. 6B, top) and bullous pemphigoid antigen...red. The open arrow indicates monocyte chemotactic protein (MCP) and closed arrow indi- cates bullous pemphigoid antigen (BPAG). B, top, isolated

Top 10 research questions related to physical activity in preschool children.

PubMed

Pate, Russell R; O'Neill, Jennifer R; Brown, William H; McIver, Kerry L; Howie, Erin K; Dowda, Marsha

2013-12-01

The purpose of this article was to highlight important research needs related to physical activity in 3- to 5-year-old children. We identified research needs in 3 major categories: health effects, patterns of physical activity, and interventions and policies. The top research needs include identifying the health effects of physical activity, the effects of physical activity on the development of healthy weight, the effects of physical activity on learning and behavior, and the health implications of sedentary behavior. Research questions concerning patterns of physical activity include determining the prevalence of 3- to 5-year-olds meeting the current physical activity guidelines; the social and environmental factors that influence physical activity in home, preschool, and community settings; and how physical activity tracks into later childhood, adolescence, and adulthood. Research questions about interventions and policies include identifying the most effective strategies to promote physical activity in home, child care, and community settings and to reach diverse populations of young children, identifying effective intervention implementation and dissemination strategies, and determining the effectiveness of national, state, local, and institutional policies for increasing physical activity. In conclusion, research is needed to establish a full understanding of the health implications of physical activity in 3- to 5-year-old children, to better understand the nature of physical activity behavior in this group, and to learn how to promote physical activity in young children.

Race to the Top - Early Learning Challenge: 2014 Annual Performance Report. Delaware

ERIC Educational Resources Information Center

Race to the Top - Early Learning Challenge, 2015

2015-01-01

This Race to the Top - Early Learning Challenge (RTT-ELC) annual performance report for the year 2014 describes Delaware's accomplishments, lessons learned, challenges, and strategies Delaware will implement to address those challenges. At the end of Year Three of the Early Learning Challenge Grant, Delaware continues to make significant progress…

Race to the Top - Early Learning Challenge: 2015 Annual Performance Report. New Jersey

ERIC Educational Resources Information Center

Race to the Top - Early Learning Challenge, 2016

2016-01-01

This Race to the Top - Early Learning Challenge (RTT-ELC) annual performance report for the year 2015 describes New Jersey's accomplishments, lessons learned, challenges, and strategies New Jersey will implement to address those challenges. New Jersey's remarkable progress in increasing participation in their tiered quality rating and improvement…

Crosslayer Survivability in Overlay-IP-WDM Networks

ERIC Educational Resources Information Center

Pacharintanakul, Peera

2010-01-01

As the Internet moves towards a three-layer architecture consisting of overlay networks on top of the IP network layer on top of WDM-based physical networks, incorporating the interaction between and among network layers is crucial for efficient and effective implementation of survivability. This dissertation has four major foci as follows:…

Teachers' Perceptions of Teaching in Workplace Simulations in Vocational Education

ERIC Educational Resources Information Center

Jossberger, Helen; Brand-Gruwel, Saskia; van de Wiel, Margje W.; Boshuizen, Henny P.

2015-01-01

In a large-scale top-down innovation operation in the Netherlands, workplace simulations have been implemented in vocational schools, where students are required to work independently and self-direct their learning. However, research has shown that the success of such large-scale top-down innovations depends on how well their execution in schools…

Photonics Academy: TOPS project

NASA Astrophysics Data System (ADS)

Tyson, Nick; Barwis, Vicky; Maghuk, Faris

2009-06-01

Technicians in Opto-Electronics Project (TOP) has five targets: one, to develop and pilot train with at least 10 learners; two, to implement a marketing plan; three, to raise awareness of the sector with young people to increase new entrants into the sector; four, to engage employers in development; and five, to provide information on leadership and management.

SOFIA - Stratospheric Observatory for Infrared Astronomy

NASA Technical Reports Server (NTRS)

Kunz, Nans; Bowers, Al

2007-01-01

This viewgraph presentation reviews the Stratospheric Observatory for Infrared Astronomy (SOFIA). The contents include: 1) Heritage & History; 2) Level 1 Requirements; 3) Top Level Overview of the Observatory; 4) Development Challenges; and 5) Highlight Photos.

Green Power Partnership Top 10 Federal Government

EPA Pesticide Factsheets

The U.S. EPA's Green Power Partnership is a voluntary program designed to reduce the environmental impact of electricity generation by promoting renewable energy. This page highlights federal agency efforts in procuring green power.

Nuclear safety policy working group recommendations on nuclear propulsion safety for the space exploration initiative

NASA Technical Reports Server (NTRS)

Marshall, Albert C.; Lee, James H.; Mcculloch, William H.; Sawyer, J. Charles, Jr.; Bari, Robert A.; Cullingford, Hatice S.; Hardy, Alva C.; Niederauer, George F.; Remp, Kerry; Rice, John W.

1993-01-01

An interagency Nuclear Safety Working Group (NSPWG) was chartered to recommend nuclear safety policy, requirements, and guidelines for the Space Exploration Initiative (SEI) nuclear propulsion program. These recommendations, which are contained in this report, should facilitate the implementation of mission planning and conceptual design studies. The NSPWG has recommended a top-level policy to provide the guiding principles for the development and implementation of the SEI nuclear propulsion safety program. In addition, the NSPWG has reviewed safety issues for nuclear propulsion and recommended top-level safety requirements and guidelines to address these issues. These recommendations should be useful for the development of the program's top-level requirements for safety functions (referred to as Safety Functional Requirements). The safety requirements and guidelines address the following topics: reactor start-up, inadvertent criticality, radiological release and exposure, disposal, entry, safeguards, risk/reliability, operational safety, ground testing, and other considerations.

Spatial processes decouple management from objectives in a heterogeneous landscape: predator control as a case study.

PubMed

Mahoney, Peter J; Young, Julie K; Hersey, Kent R; Larsen, Randy T; McMillan, Brock R; Stoner, David C

2018-04-01

Predator control is often implemented with the intent of disrupting top-down regulation in sensitive prey populations. However, ambiguity surrounding the efficacy of predator management, as well as the strength of top-down effects of predators in general, is often exacerbated by the spatially implicit analytical approaches used in assessing data with explicit spatial structure. Here, we highlight the importance of considering spatial context in the case of a predator control study in south-central Utah. We assessed the spatial match between aerial removal risk in coyotes (Canis latrans) and mule deer (Odocoileus hemionus) resource selection during parturition using a spatially explicit, multi-level Bayesian model. With our model, we were able to evaluate spatial congruence between management action (i.e., coyote removal) and objective (i.e., parturient deer site selection) at two distinct scales: the level of the management unit and the individual coyote removal. In the case of the former, our results indicated substantial spatial heterogeneity in expected congruence between removal risk and parturient deer site selection across large areas, and is a reflection of logistical constraints acting on the management strategy and differences in space use between the two species. At the level of the individual removal, we demonstrated that the potential management benefits of a removed coyote were highly variable across all individuals removed and in many cases, spatially distinct from parturient deer resource selection. Our methods and results provide a means of evaluating where we might anticipate an impact of predator control, while emphasizing the need to weight individual removals based on spatial proximity to management objectives in any assessment of large-scale predator control. Although we highlight the importance of spatial context in assessments of predator control strategy, we believe our methods are readily generalizable in any management or large-scale experimental framework where spatial context is likely an important driver of outcomes. © 2018 by the Ecological Society of America.

Screen printed silver top electrode for efficient inverted organic solar cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Junwoo; Duraisamy, Navaneethan; Lee, Taik-Min

2015-10-15

Highlights: • Screen printing of silver pattern. • X-ray diffraction pattern confirmed the face centered cubic structure of silver. • Uniform surface morphology of silver pattern with sheet resistance of 0.06 Ω/sq. • The power conversion efficiency of fabricated solar cell is found to be 2.58%. - Abstract: The present work is mainly focused on replacement of the vacuum process for top electrode fabrication in organic solar cells. Silver top electrode deposited through solution based screen printing on pre-deposited polymeric thin film. The solution based printing technology provides uniform top electrode without damaging the underlying organic layers. The surface crystallinitymore » and surface morphology of silver top electrode are examined through X-ray diffraction, field-emission scanning electron microscope and atomic force microscope. The purity of silver is examined through X-ray energy dispersive spectroscopy. The top electrode exhibits face centered cubic structure with homogeneous morphology. The sheet resistance of top electrode is found to be 0.06 Ω/sq and an average pattern thickness of ∼15 μm. The power conversion efficiency is 2.58%. Our work demonstrates that the solution based screen printing is a significant role in the replacement of vacuum process for the fabrication of top electrode in organic solar cells.« less

The roles of large top predators in coastal ecosystems: new insights from long term ecological research

USGS Publications Warehouse

Rosenblatt, Adam E.; Heithaus, Michael R.; Mather, Martha E.; Matich, Philip; Nifong, James C.; Ripple, William J.; Silliman, Brian R.

2013-01-01

During recent human history, human activities such as overhunting and habitat destruction have severely impacted many large top predator populations around the world. Studies from a variety of ecosystems show that loss or diminishment of top predator populations can have serious consequences for population and community dynamics and ecosystem stability. However, there are relatively few studies of the roles of large top predators in coastal ecosystems, so that we do not yet completely understand what could happen to coastal areas if large top predators are extirpated or significantly reduced in number. This lack of knowledge is surprising given that coastal areas around the globe are highly valued and densely populated by humans, and thus coastal large top predator populations frequently come into conflict with coastal human populations. This paper reviews what is known about the ecological roles of large top predators in coastal systems and presents a synthesis of recent work from three coastal eastern US Long Term Ecological Research (LTER) sites where long-term studies reveal what appear to be common themes relating to the roles of large top predators in coastal systems. We discuss three specific themes: (1) large top predators acting as mobile links between disparate habitats, (2) large top predators potentially affecting nutrient and biogeochemical dynamics through localized behaviors, and (3) individual specialization of large top predator behaviors. We also discuss how research within the LTER network has led to enhanced understanding of the ecological roles of coastal large top predators. Highlighting this work is intended to encourage further investigation of the roles of large top predators across diverse coastal aquatic habitats and to better inform researchers and ecosystem managers about the importance of large top predators for coastal ecosystem health and stability.

Assessing the suitability of a manometric test system for determining the biodegradability of volatile hydrocarbons.

PubMed

Brown, David M; Hughes, Christopher B; Spence, Michael; Bonte, Matthijs; Whale, Graham

2018-03-01

Manometric test systems, adapted from those used to measure biochemical oxygen demand (BOD), and the OxiTop ® test system in particular, are being increasingly used to determine the biodegradability of chemicals in accordance to OECD 301F guidelines. In this study, the suitability of the OxiTop ® test system for determining the biodegradability of volatile hydrophobic substances has been explored. Experiments in biotic and abiotic systems were conducted with readily biodegradable complex aliphatic hydrocarbons covering a range of volatilities. Results indicated that abiotic losses of test substances were occurring due to sorption of the test substance to plastic components used in the OxiTop ® system. A further 'plastic-free' biodegradation test system was designed using PreSens optical dissolved oxygen (DO) sensors. This significantly improved the measured biodegradation due to reduced abiotic losses and better retention of the test substance. These results highlight the importance of considering the physico-chemical properties of test substances when selecting test methods and equipment. They also highlight the value of incorporating chemical analysis and abiotic controls to improve the interpretation of biodegradation studies. Copyright © 2017. Published by Elsevier Ltd.

Race to the Top - Early Learning Challenge: 2014 Annual Performance Report Kentucky

ERIC Educational Resources Information Center

Race to the Top - Early Learning Challenge, 2015

2015-01-01

This Race to the Top - Early Learning Challenge (RTT-ELC) annual performance report for the year 2014 describes Kentucky's accomplishments, lessons learned, challenges, and strategies Kentucky will implement to address those challenges. In December of 2013, Kentucky received notice that they would join 19 other States as a winner of the Race to…

Implementing RtI with Gifted Students

ERIC Educational Resources Information Center

Coleman, Mary Ruth, Ed.; Johnsen, Susan K., Ed.

2012-01-01

"Implementing RtI With Gifted Students" shares how RtI can fit within the framework of gifted education programming models. This edited book will serve as a reference guide for those interested in learning more about RtI and how it might be effectively implemented to meet the needs of all gifted students. Chapters contributed by top gifted…

Exploring Strengths of Career Technical Education Deans: Implementing Change within Community Colleges

ERIC Educational Resources Information Center

Davis, Maria

2013-01-01

The purpose of this qualitative study was to explore how career technical education (CTE) deans implement crucial changes in their programs to keep up with industry standards required by external agencies, the Perkins grant, and the advancements of technology. Deans must make top-down, lateral, as well as vertical change to implement improvements…

Studying Implementation within a Continuous Continuous-Improvement Process: What Happens When We Design with Adaptations in Mind?

ERIC Educational Resources Information Center

Tichnor-Wagner, Ariel; Allen, Danielle; Socol, Allison Rose; Cohen-Vogel, Lora; Rutledge, Stacey A.; Xing, Qi W.

2018-01-01

Background/Context: This study examines the implementation of an academic and social-emotional learning innovation called Personalization for Academic and Social-Emotional Learning, or PASL. The innovation was designed, tested, and implemented using a continuous continuous-improvement model. The model emphasized a top-and-bottom process in which…

Community Evolution in International Migration Top1 Networks.

PubMed

Peres, Mihaela; Xu, Helian; Wu, Gang

2016-01-01

Focusing on each country's topmost destination/origin migration relation with other countries, this study builds top1 destination networks and top1 origin networks in order to understand their skeletal construction and community dynamics. Each top1 network covers approximately 50% of the complete migrant network stock for each decade between 1960 and 2000. We investigate the community structure by implementing the Girvan-Newman algorithm and compare the number of components and communities to illustrate their differences. We find that (i) both top1 networks (origin and destination) exhibited communities with a clear structure and a surprising evolution, although 80% edges persist between each decade; (ii) top1 destination networks focused on developed countries exhibiting shorter paths and preferring more advance countries, while top1 origin networks focused both on developed as well as more substantial developing nations that presented a longer path and more stable groups; (iii) only few countries have a decisive influence on community evolution of both top1 networks. USA took the leading position as a destination country in top1 destination networks, while China and India were the main Asian emigration countries in top1 origin networks; European countries and the Russian Federation played an important role in both.

Community Evolution in International Migration Top1 Networks

PubMed Central

Xu, Helian

2016-01-01

Focusing on each country’s topmost destination/origin migration relation with other countries, this study builds top1 destination networks and top1 origin networks in order to understand their skeletal construction and community dynamics. Each top1 network covers approximately 50% of the complete migrant network stock for each decade between 1960 and 2000. We investigate the community structure by implementing the Girvan-Newman algorithm and compare the number of components and communities to illustrate their differences. We find that (i) both top1 networks (origin and destination) exhibited communities with a clear structure and a surprising evolution, although 80% edges persist between each decade; (ii) top1 destination networks focused on developed countries exhibiting shorter paths and preferring more advance countries, while top1 origin networks focused both on developed as well as more substantial developing nations that presented a longer path and more stable groups; (iii) only few countries have a decisive influence on community evolution of both top1 networks. USA took the leading position as a destination country in top1 destination networks, while China and India were the main Asian emigration countries in top1 origin networks; European countries and the Russian Federation played an important role in both. PMID:26859406

Application of RF-MEMS-Based Split Ring Resonators (SRRs) to the Implementation of Reconfigurable Stopband Filters: A Review

PubMed Central

Martín, Ferran; Bonache, Jordi

2014-01-01

In this review paper, several strategies for the implementation of reconfigurable split ring resonators (SRRs) based on RF-MEMS switches are presented. Essentially three types of RF-MEMS combined with split rings are considered: (i) bridge-type RF-MEMS on top of complementary split ring resonators CSRRs; (ii) cantilever-type RF-MEMS on top of SRRs; and (iii) cantilever-type RF-MEMS integrated with SRRs (or RF-MEMS SRRs). Advantages and limitations of these different configurations from the point of view of their potential applications for reconfigurable stopband filter design are discussed, and several prototype devices are presented. PMID:25474378

Dark decay of the top quark

DOE PAGES

Kong, Kyoungchul; Lee, Hye -Sung; Park, Myeonghun

2014-04-01

We suggest top quark decays as a venue to search for light dark force carriers. Top quark is the heaviest particle in the standard model whose decays are relatively poorly measured, allowing sufficient room for exotic decay modes from new physics. A very light (GeV scale) dark gauge boson (Z') is a recently highlighted hypothetical particle that can address some astrophysical anomalies as well as the 3.6 σ deviation in the muon g-2 measurement. We present and study a possible scenario that top quark decays as t → b W + Z's. This is the same as the dominant topmore » quark decay (t → b W) accompanied by one or multiple dark force carriers. The Z' can be easily boosted, and it can decay into highly collimated leptons (lepton-jet) with large branching ratio. In addition, we discuss the implications for the Large Hadron Collider experiments including the analysis based on the lepton-jets.« less

Top down, bottom up structured programming and program structuring

NASA Technical Reports Server (NTRS)

Hamilton, M.; Zeldin, S.

1972-01-01

New design and programming techniques for shuttle software. Based on previous Apollo experience, recommendations are made to apply top-down structured programming techniques to shuttle software. New software verification techniques for large software systems are recommended. HAL, the higher order language selected for the shuttle flight code, is discussed and found to be adequate for implementing these techniques. Recommendations are made to apply the workable combination of top-down, bottom-up methods in the management of shuttle software. Program structuring is discussed relevant to both programming and management techniques.

First experience with the new .cern Top Level Domain

NASA Astrophysics Data System (ADS)

Alvarez, E.; Malo de Molina, M.; Salwerowicz, M.; Silva De Sousa, B.; Smith, T.; Wagner, A.

2017-10-01

In October 2015, CERN’s core website has been moved to a new address, http://home.cern, marking the launch of the brand new top-level domain .cern. In combination with a formal governance and registration policy, the IT infrastructure needed to be extended to accommodate the hosting of Web sites in this new top level domain. We will present the technical implementation in the framework of the CERN Web Services that allows to provide virtual hosting, a reverse proxy solution and that also includes the provisioning of SSL server certificates for secure communications.

Terrorism preparedness: Web-based resource management and the TOPOFF 3 exercise.

PubMed

Jacobs, Lenworth M; Burns, Karyl J

2006-03-01

The bombings of London on July 7, 2005 highlight the need for continued vigilance and readiness to respond to terrorist attacks. Trauma centers need to be at the core of preparedness activities. The State of Connecticut has taken a lead in preparedness and was selected as a site for the US Department of Homeland Security's Top Officials Three Exercise (TOPOFF 3), the largest and most extensive antiterrorism drill ever conducted. All 32 acute care hospitals in Connecticut took part in the drill. The simulated attacks were designed to test all aspects of emergency preparedness including the ability of hospitals to treat large numbers of victims and effectively monitor and implement mechanisms for surge capacity. In Connecticut, TOPOFF 3 tested the Bioterrorism Preparedness Web Application that was designed to be the primary communication and resource management tool during a terrorist event or public health emergency. This paper describes: 1) the impetus for the State of Connecticut Department of Public Health's Bioterrorism Preparedness Web Application; 2) the strategies used to ensure its readiness and appropriate utilization during a public health emergency; and 3) its use for communication and resource management by the Department of Public Health and the acute care hospitals during TOPOFF 3. The Bioterrorism Preparedness Web Application was successfully implemented and used during TOPOFF 3 to assess surge capacity and other resources. Careful development and implementation of the Web application, or any communication system, as well as training and regular practice are required to ensure effective use during a public health emergency.

Science for a wilder Anthropocene: Synthesis and future directions for trophic rewilding research.

PubMed

Svenning, Jens-Christian; Pedersen, Pil B M; Donlan, C Josh; Ejrnæs, Rasmus; Faurby, Søren; Galetti, Mauro; Hansen, Dennis M; Sandel, Brody; Sandom, Christopher J; Terborgh, John W; Vera, Frans W M

2016-01-26

Trophic rewilding is an ecological restoration strategy that uses species introductions to restore top-down trophic interactions and associated trophic cascades to promote self-regulating biodiverse ecosystems. Given the importance of large animals in trophic cascades and their widespread losses and resulting trophic downgrading, it often focuses on restoring functional megafaunas. Trophic rewilding is increasingly being implemented for conservation, but remains controversial. Here, we provide a synthesis of its current scientific basis, highlighting trophic cascades as the key conceptual framework, discussing the main lessons learned from ongoing rewilding projects, systematically reviewing the current literature, and highlighting unintentional rewilding and spontaneous wildlife comebacks as underused sources of information. Together, these lines of evidence show that trophic cascades may be restored via species reintroductions and ecological replacements. It is clear, however, that megafauna effects may be affected by poorly understood trophic complexity effects and interactions with landscape settings, human activities, and other factors. Unfortunately, empirical research on trophic rewilding is still rare, fragmented, and geographically biased, with the literature dominated by essays and opinion pieces. We highlight the need for applied programs to include hypothesis testing and science-based monitoring, and outline priorities for future research, notably assessing the role of trophic complexity, interplay with landscape settings, land use, and climate change, as well as developing the global scope for rewilding and tools to optimize benefits and reduce human-wildlife conflicts. Finally, we recommend developing a decision framework for species selection, building on functional and phylogenetic information and with attention to the potential contribution from synthetic biology.

Science for a wilder Anthropocene: Synthesis and future directions for trophic rewilding research

PubMed Central

Svenning, Jens-Christian; Pedersen, Pil B. M.; Donlan, C. Josh; Ejrnæs, Rasmus; Faurby, Søren; Galetti, Mauro; Hansen, Dennis M.; Sandel, Brody; Sandom, Christopher J.; Terborgh, John W.; Vera, Frans W. M.

2016-01-01

Trophic rewilding is an ecological restoration strategy that uses species introductions to restore top-down trophic interactions and associated trophic cascades to promote self-regulating biodiverse ecosystems. Given the importance of large animals in trophic cascades and their widespread losses and resulting trophic downgrading, it often focuses on restoring functional megafaunas. Trophic rewilding is increasingly being implemented for conservation, but remains controversial. Here, we provide a synthesis of its current scientific basis, highlighting trophic cascades as the key conceptual framework, discussing the main lessons learned from ongoing rewilding projects, systematically reviewing the current literature, and highlighting unintentional rewilding and spontaneous wildlife comebacks as underused sources of information. Together, these lines of evidence show that trophic cascades may be restored via species reintroductions and ecological replacements. It is clear, however, that megafauna effects may be affected by poorly understood trophic complexity effects and interactions with landscape settings, human activities, and other factors. Unfortunately, empirical research on trophic rewilding is still rare, fragmented, and geographically biased, with the literature dominated by essays and opinion pieces. We highlight the need for applied programs to include hypothesis testing and science-based monitoring, and outline priorities for future research, notably assessing the role of trophic complexity, interplay with landscape settings, land use, and climate change, as well as developing the global scope for rewilding and tools to optimize benefits and reduce human–wildlife conflicts. Finally, we recommend developing a decision framework for species selection, building on functional and phylogenetic information and with attention to the potential contribution from synthetic biology. PMID:26504218

Vessel traffic patterns in the Port of Kaohsiung and the management implications for preventing the introduction of non-indigenous aquatic species.

PubMed

Liu, Ta-Kang; Tsai, Tzung-Kuen

2011-03-01

Data on shipping traffic in one of the busiest seaports in the world, the Port of Kaohsiung, were analyzed to evaluate the implications for ballast water management. Results show that 67% of the arriving vessels were registered to a flag of convenience, which typically have a lower degree of environmental records. The top five donor countries historically suffer from harmful algal bloom problems. The short journey and busy trading between these countries and Taiwan lead to a higher risk of inoculation. In addition, only 1.4% of all vessels visited more than once every year during the 9-year span, indicating that the port authority encounters many new vessels each year. These findings could influence the design and application of ballast water management strategies as well as highlight the challenges in their implementation. We suggest that an analysis of vessel traffic patterns should be coupled with other useful vessel information to make risk assessment successful. Copyright © 2010. Published by Elsevier Ltd.

Survey of student attitudes towards digital simulation technologies at a dental school in China.

PubMed

Ren, Q; Wang, Y; Zheng, Q; Ye, L; Zhou, X D; Zhang, L L

2017-08-01

Digital simulation technologies have become widespread in healthcare education, especially in dentistry; these technologies include digital X-ray images, digital microscopes, virtual pathology slides and other types of simulation. This study aimed to assess students' attitudes towards digital simulation technologies at a large, top-ranked dental school in China, as well as find out how students compare the digital technologies with traditional training methods. In April 2015, a custom-designed questionnaire was distributed to a total of 389 students who had received digital technology and simulation-based training in West China Dental School during 2012-2014. Results of a cross-sectional survey show that most students accept digital simulation technology; they report that the technology is stimulating and facilitates self-directed and self-paced learning. These findings, together with the objective advantages of digital technology, suggest that digital simulation training offers significant potential for dental education, highlighting the need for further research and more widespread implementation. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

The Importance of Simulation Workflow and Data Management in the Accelerated Climate Modeling for Energy Project

NASA Astrophysics Data System (ADS)

Bader, D. C.

2015-12-01

The Accelerated Climate Modeling for Energy (ACME) Project is concluding its first year. Supported by the Office of Science in the U.S. Department of Energy (DOE), its vision is to be "an ongoing, state-of-the-science Earth system modeling, modeling simulation and prediction project that optimizes the use of DOE laboratory resources to meet the science needs of the nation and the mission needs of DOE." Included in the "laboratory resources," is a large investment in computational, network and information technologies that will be utilized to both build better and more accurate climate models and broadly disseminate the data they generate. Current model diagnostic analysis and data dissemination technologies will not scale to the size of the simulations and the complexity of the models envisioned by ACME and other top tier international modeling centers. In this talk, the ACME Workflow component plans to meet these future needs will be described and early implementation examples will be highlighted.

Democratizing molecular diagnostics for the developing world.

PubMed

Abou Tayoun, Ahmad N; Burchard, Paul R; Malik, Imran; Scherer, Axel; Tsongalis, Gregory J

2014-01-01

Infectious diseases that are largely treatable continue to pose a tremendous burden on the developing world despite the availability of highly potent drugs. The high mortality and morbidity rates of these diseases are largely due to a lack of affordable diagnostics that are accessible to resource-limited areas and that can deliver high-quality results. In fact, modified molecular diagnostics for infectious diseases were rated as the top biotechnology to improve health in developing countries. In this review, we describe the characteristics of accessible molecular diagnostic tools and discuss the challenges associated with implementing such tools at low infrastructure sites. We highlight our experience as part of the "Grand Challenge" project supported by the Gates Foundation for addressing global health inequities and describe issues and solutions associated with developing adequate technologies or molecular assays needed for broad access in the developing world. We believe that sharing this knowledge will facilitate the development of new molecular technologies that are extremely valuable for improving global health.

French vertical flow constructed wetlands: a need of a better understanding of the role of the deposit layer.

PubMed

Molle, Pascal

2014-01-01

French vertical flow constructed wetlands, treating directly raw wastewater, have become the main systems implemented for communities under 2,000 population equivalent in France. Like in sludge drying reed beds, an organic deposit layer is formed over time at the top surface of the filter. This deposit layer is a key factor in the performance of the system as it impacts hydraulic, gas transfers, filtration efficiency and water retention time. The paper discusses the role of this deposit layer on the hydraulic and biological behaviour of the system. It presents results from different studies to highlight the positive role of the layer but, as well, the difficulties in modelling this organic layer. As hydraulic, oxygen transfers, and biological activity are interlinked and impacted by the deposit layer, it seems essential to focus on its role (and its quantification) to find new developments of vertical flow constructed wetlands fed with raw wastewater.

Data analytics approach to create waste generation profiles for waste management and collection.

PubMed

Niska, Harri; Serkkola, Ari

2018-04-30

Extensive monitoring data on waste generation is increasingly collected in order to implement cost-efficient and sustainable waste management operations. In addition, geospatial data from different registries of the society are opening for free usage. Novel data analytics approaches can be built on the top of the data to produce more detailed, and in-time waste generation information for the basis of waste management and collection. In this paper, a data-based approach based on the self-organizing map (SOM) and the k-means algorithm is developed for creating a set of waste generation type profiles. The approach is demonstrated using the extensive container-level waste weighting data collected in the metropolitan area of Helsinki, Finland. The results obtained highlight the potential of advanced data analytic approaches in producing more detailed waste generation information e.g. for the basis of tailored feedback services for waste producers and the planning and optimization of waste collection and recycling. Copyright © 2018 Elsevier Ltd. All rights reserved.

Race to the Top - Early Learning Challenge: 2015 Annual Performance Report. New Mexico

ERIC Educational Resources Information Center

Race to the Top - Early Learning Challenge, 2016

2016-01-01

This Race to the Top - Early Learning Challenge (RTT-ELC) annual performance report for the year 2015 describes New Mexico's accomplishments, lessons learned, challenges, and strategies New Mexico will implement to address those challenges. New Mexico is pleased to report that at the end of Year Three of the RTT-ELC grant, the State continues to…

Race to the Top: Implementation and Relationship to Student Outcomes. NCEE 2017-4001

ERIC Educational Resources Information Center

Dragoset, Lisa; Thomas, Jaime; Herrmann, Mariesa; Deke, John; James-Burdumy, Susanne; Graczewski, Cheryl; Boyle, Andrea; Tanenbaum, Courtney; Giffin, Jessica; Upton, Rachel

2016-01-01

Race to the Top (RTT), one of the Obama administration's signature programs and one of the largest federal government investments in an education grant program, received $4.35 billion in funding as part of the American Recovery and Reinvestment Act of 2009. Through three rounds of competition in 2010 and 2011, RTT awarded grants to states that…

Improving Low-Achieving Schools: Building State Capacity to Support School Improvement through Race to the Top

ERIC Educational Resources Information Center

Childs, Joshua; Russell, Jennifer Lin

2017-01-01

Improving low-achieving schools is a critical challenge facing urban education. Recent national policy shifts have pressed states to take an expanded role in school improvement efforts. In 2009, a federal grant competition called Race to the Top (RttT) compelled states to improve their capacity to implement ambitious education reform agendas.…

State Requirements for Teacher Evaluation Policies Promoted by Race to the Top. NCEE Evaluation Brief. NCEE 2014-4016

ERIC Educational Resources Information Center

Hallgren, Kristin; James-Burdumy, Susanne; Perez-Johnson, Irma

2014-01-01

This brief describes the extent to which states required teacher evaluation policies aligned with the Race to the Top (RTT) initiative as of spring 2012. Although teacher evaluation policies appear to be rapidly evolving, documenting policy requirements in the early years of RTT implementation can help inform policymakers about the pace of policy…

What Would You Ideally Do if There Were No Targets? An Ethnographic Study of the Unintended Consequences of Top-Down Governance in Two Clinical Settings

ERIC Educational Resources Information Center

Allard, Jon; Bleakley, Alan

2016-01-01

Top-down policy directives, such as targets and their associated protocols, may be driven politically rather than clinically and can be described as macro-political texts. While targets supposedly provide incentives for healthcare services, they may unintentionally shape practices of accommodation rather than implementation, deflecting…

Microcomputers in Academic Departments: The Consequences of Implementing Distributive Desk-Top Computing to Faculty and Staff.

ERIC Educational Resources Information Center

Winans, Glen T.

This paper presents a descriptive review of how the Provost's Office of the College of Letters and Science at the University of California, Santa Barbara (UCSB) implemented 330 microcomputers in the 34 academic departments from July 1984 through June 1986. The decision to implement stand-alone microcomputers was based on four concerns: increasing…

Team Teaching among Mixed Messages: Implementing Two-Way Dual Language Bilingual Education at Third Grade in Texas

ERIC Educational Resources Information Center

Palmer, Deborah; Henderson, Kathryn; Wall, Dorothy; Zúñiga, Christian E.; Berthelsen, Stefan

2016-01-01

This article documents and interrogates top-down district-wide implementation of a two-way dual language bilingual education (DLBE) program in a large urban district. We carried out a language policy ethnography to explore the way two schools' teams of third grade teachers worked together to negotiate the intersection of DLBE implementation and…

DNA Topoisomerases of Leishmania parasites; druggable targets for drug discovery.

PubMed

Reguera, Rosa Mª; Elmahallawy, Ehab Kotb; Garcia-Estrada, Carlos; Carbajo-Andres, Ruben; Balana-Fouce, Rafael

2018-05-17

DNA topoisomerases (Top) are a group of isomerase enzymes responsible for controlling the topological problems caused by DNA double helix in the cell during the processes of replication, transcription and recombination. Interestingly, these enzymes have been known since long to be key molecular machines in several cellular processes through overwinding or underwinding of DNA in all-living organisms. Leishmania, a trypanosomatid parasite responsible for causing fatal diseases mostly in impoverished populations of low-income countries, have a set of six classes of Top enzymes. These are placed in the nucleus and the single mitochondrion and can be deadly targets of suitable drugs. Given the fact that there are clear differences in structure and expression between parasite and host enzymes, numerous studies have reported the therapeutic potential of Top inhibitors as antileishmanial drugs. In this regard, numerous compounds have been described as Top type IB and Top type II inhibitors in Leishmania parasites, such as camptothecin derivatives, indenoisoquinolines, indeno-1,5-naphthyridines, fluoroquinolones, antracyclines and podophyllotoxins. The aim of this review is to highlight several facts about Top and Top inhibitors as potential antileishmanial drugs, which may represent a promising strategy for the control of this disease of public health importance. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Other side of the coin for personalised medicine and healthcare: content analysis of ‘personalised’ practices in the literature

PubMed Central

Cesuroglu, Tomris; Syurina, Elena; Feron, Frans; Krumeich, Anja

2016-01-01

Objectives Various terms and definitions are used to describe personalised approaches to medicine and healthcare, but in ambiguous and inconsistent ways. They mostly have been defined in a top-down manner. However, actual practices might take different paths. Here, we aimed to provide a ‘practice-based’ perspective on the debate by analysing the content of ‘personalised’ practices published in the literature. Methods The search in PubMed and EMBASE (April 2014) using the terms frequently used for personalised approaches resulted in 5333 records. 2 independent researchers used different strategies for screening, resulting in 157 articles describing 88 ‘personalised’ practices that were implemented/presented on at least 1 individual/patient case. The content analysis was grounded on these data and did not have a priori analytical frameworks. Results ‘Personalised medicine/healthcare’ can be a commodity in the healthcare market, a way how health services are provided, or a keyword for emerging applications. It can help individuals/patients to gain control of their health, health professionals to provide better services, healthcare organisations to increase effectiveness and efficiency, or national health systems to increase performance. Country examples indicated that for integration of practices into health services, attitude towards innovations and health system and policy context is important. Categorisation based on the terms or the technologies used, if any, was not possible. Conclusions This study is the first to provide a comprehensive content analysis of the ‘personalised’ practices in the literature. Unlike the top-down definitions, our findings highlighted not the technologies but real-life issues faced by the practices. ‘Personalised medicine’ and ‘personalised healthcare’ can be differentiated by using the former for specific tools available and the latter for health services with a holistic approach, implemented in certain contexts. To realise integration of ‘personalised medicine/healthcare’ into real life, science, technology, health policy and practice, and society domains must work together. PMID:27412099

Public library consumer health information pilot project: results of a National Library of Medicine evaluation

PubMed Central

Wood, Fred B.; Lyon, Becky; Schell, Mary Beth; Kitendaugh, Paula; Cid, Victor H.; Siegel, Elliot R.

2000-01-01

In October 1998, the National Library of Medicine (NLM) launched a pilot project to learn about the role of public libraries in providing health information to the public and to generate information that would assist NLM and the National Network of Libraries of Medicine (NN/LM) in learning how best to work with public libraries in the future. Three regional medical libraries (RMLs), eight resource libraries, and forty-one public libraries or library systems from nine states and the District of Columbia were selected for participation. The pilot project included an evaluation component that was carried out in parallel with project implementation. The evaluation ran through September 1999. The results of the evaluation indicated that participating public librarians were enthusiastic about the training and information materials provided as part of the project and that many public libraries used the materials and conducted their own outreach to local communities and groups. Most libraries applied the modest funds to purchase additional Internet-accessible computers and/or upgrade their health-reference materials. However, few of the participating public libraries had health information centers (although health information was perceived as a top-ten or top-five topic of interest to patrons). Also, the project generated only minimal usage of NLM's consumer health database, known as MEDLINEplus, from the premises of the monitored libraries (patron usage from home or office locations was not tracked). The evaluation results suggested a balanced follow-up by NLM and the NN/LM, with a few carefully selected national activities, complemented by a package of targeted activities that, as of January 2000, are being planned, developed, or implemented. The results also highlighted the importance of building an evaluation component into projects like this one from the outset, to assure that objectives were met and that evaluative information was available on a timely basis, as was the case here. PMID:11055298

Public library consumer health information pilot project: results of a National Library of Medicine evaluation.

PubMed

Wood, F B; Lyon, B; Schell, M B; Kitendaugh, P; Cid, V H; Siegel, E R

2000-10-01

In October 1998, the National Library of Medicine (NLM) launched a pilot project to learn about the role of public libraries in providing health information to the public and to generate information that would assist NLM and the National Network of Libraries of Medicine (NN/LM) in learning how best to work with public libraries in the future. Three regional medical libraries (RMLs), eight resource libraries, and forty-one public libraries or library systems from nine states and the District of Columbia were selected for participation. The pilot project included an evaluation component that was carried out in parallel with project implementation. The evaluation ran through September 1999. The results of the evaluation indicated that participating public librarians were enthusiastic about the training and information materials provided as part of the project and that many public libraries used the materials and conducted their own outreach to local communities and groups. Most libraries applied the modest funds to purchase additional Internet-accessible computers and/or upgrade their health-reference materials. However, few of the participating public libraries had health information centers (although health information was perceived as a top-ten or top-five topic of interest to patrons). Also, the project generated only minimal usage of NLM's consumer health database, known as MEDLINEplus, from the premises of the monitored libraries (patron usage from home or office locations was not tracked). The evaluation results suggested a balanced follow-up by NLM and the NN/LM, with a few carefully selected national activities, complemented by a package of targeted activities that, as of January 2000, are being planned, developed, or implemented. The results also highlighted the importance of building an evaluation component into projects like this one from the outset, to assure that objectives were met and that evaluative information was available on a timely basis, as was the case here.

TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription.

PubMed

Gómez-Herreros, Fernando; Zagnoli-Vieira, Guido; Ntai, Ioanna; Martínez-Macías, María Isabel; Anderson, Rhona M; Herrero-Ruíz, Andrés; Caldecott, Keith W

2017-08-10

DNA double-strand breaks (DSBs) induced by abortive topoisomerase II (TOP2) activity are a potential source of genome instability and chromosome translocation. TOP2-induced DNA double-strand breaks are rejoined in part by tyrosyl-DNA phosphodiesterase 2 (TDP2)-dependent non-homologous end-joining (NHEJ), but whether this process suppresses or promotes TOP2-induced translocations is unclear. Here, we show that TDP2 rejoins DSBs induced during transcription-dependent TOP2 activity in breast cancer cells and at the translocation 'hotspot', MLL. Moreover, we find that TDP2 suppresses chromosome rearrangements induced by TOP2 and reduces TOP2-induced chromosome translocations that arise during gene transcription. Interestingly, however, we implicate TDP2-dependent NHEJ in the formation of a rare subclass of translocations associated previously with therapy-related leukemia and characterized by junction sequences with 4-bp of perfect homology. Collectively, these data highlight the threat posed by TOP2-induced DSBs during transcription and demonstrate the importance of TDP2-dependent non-homologous end-joining in protecting both gene transcription and genome stability.DNA double-strand breaks (DSBs) induced by topoisomerase II (TOP2) are rejoined by TDP2-dependent non-homologous end-joining (NHEJ) but whether this promotes or suppresses translocations is not clear. Here the authors show that TDP2 suppresses chromosome translocations from DSBs introduced during gene transcription.

Dermatologic Features of Classic Movie Villains: The Face of Evil.

PubMed

Croley, Julie Amthor; Reese, Vail; Wagner, Richard F

2017-06-01

Dichotomous dermatologic depictions of heroes and villains in movies have been used since the silent film age. To evaluate the hero-villain skin dichotomy in film by (1) identifying dermatologic findings of the all-time top 10 American film villains, (2) comparing these dermatologic findings to the all-time top 10 American film heroes quantitatively and qualitatively, and (3) analyzing dermatologic portrayals of film villains in depth. In this cross-sectional study, dermatologic findings for film heroes and villains in mainstream media were identified and compared quantitatively using a χ2 test with α < .05, as well as qualitatively. The all-time top 10 American film villains and heroes were obtained from the American Film Institute 100 Greatest Heroes and Villains List. Primary outcomes include identification and frequencies of dermatologic findings of the top 10 film villains and of the top 10 film heroes. Six (60%) of the all-time top 10 American film villains have dermatologic findings, including cosmetically significant alopecia (30%), periorbital hyperpigmentation (30%), deep rhytides on the face (20%), multiple facial scars (20%), verruca vulgaris on the face (20%), and rhinophyma (10%). The top 10 villains have a higher incidence of significant dermatologic findings than the top 10 heroes (60% vs 0%; P = .03). Dermatologic findings of the all-time top 10 American villains are used in film to highlight the dichotomy of good and evil, which may foster a tendency toward prejudice in our society directed at those with skin disease.

Jovian Cloud Tops

NASA Image and Video Library

2017-05-18

This enhanced color view of Jupiter's cloud tops was processed by citizen scientist Bjorn Jonsson using data from the JunoCam instrument on NASA's Juno spacecraft. The image highlights a massive counterclockwise rotating storm that appears as a white oval in the gas giant's southern hemisphere. Juno acquired this image on Feb. 2, 2017, at 6:13 a.m. PDT (9:13 a.m. EDT), as the spacecraft performed a close flyby of Jupiter. When the image was taken, the spacecraft was about 9,000 miles (14,500 kilometers) from the planet. https://photojournal.jpl.nasa.gov/catalog/PIA21391

Foodborne botulism associated with home-preserved turnip tops in Italy.

PubMed

Anniballi, Fabrizio; Chironna, Elisa; Astegiano, Sara; Fiore, Alfonsina; Auricchio, Bruna; Buonincontro, Giuseppina; Corvonato, Maria; Segala, Vincenzo; Mandarino, Giuseppina; De Medici, Dario; Decastelli, Lucia

2015-01-01

In Italy, foodborne botulism is a rare disease mainly due to home-preserved food. In the case reported here, clinical diagnosis was performed on the basis of clinical signs and referred consumption of home-preserved turnip tops in oil. Definitive diagnosis was performed by detection of botulinum toxin in sera and neuro-toxigenic organisms in stools and leftover food. This case report highlights the need of a high medical awareness, prompt clinical diagnosis, and synergic collaboration among the health authorities for a correct management of botulism as well as disease containment.

NASA Student Competitions

NASA Technical Reports Server (NTRS)

Ward, Elizabeth B.

2008-01-01

Topics covered include: I. Aeronautics Contest: a) High school and college students; b) Participation based on academic calendar; c) Vehicles and Systems; d) High School Division 2007 Highlights: 1) Top score for international teams..... girls from South Africa; 2) Top scores overall for individuals..... US and International were girls; f) Participating Countries: South Africa, India, Pakistan, Romania, Canada. II. Life and Work on the Moon: What images come to mind. a) Architecture; b) Industrial design; c) Computer Design; d) Fine arts. III. Next Generation Moon Buggy Contest: a) High School and College students; b) Real vehicles; c) Real missions.

80GHz waveform generator by optical Fourier synthesis of four spectral sidebands (Conference Presentation)

NASA Astrophysics Data System (ADS)

Fatome, Julien; Hammani, Kamal; Kibler, Bertrand; Finot, Christophe

2016-04-01

Versatile and easy to implement methods to generate arbitrary optical waveforms at high repetition rates are of considerable interest with applications in optical communications, all-optical signal processing, instrumentation systems and microwave signal manipulation. While shaping sinusoidal, Gaussian or hyperbolic secant intensity profiles is commonly achieved by means of modulators or mode-locked lasers, other pulse profiles such as parabolic, triangular or flat-top shapes still remain challenging to synthesize. In this context, several strategies were already explored. First, the linear pulse shaping is a common method to carve an initial ultrashort pulse train into the desired shape. The line-by-line shaping of a coherent frequency comb made of tens of spectral components was also investigated to generate more complex structures whereas Fourier synthesis of a few discrete frequencies spectrum was exploited to efficiently generate high-fidelity ultrafast periodic intensity profiles. Besides linear shaping techniques, several nonlinear methods were implemented to benefit from the adiabatic evolution of the intensity pulse profile upon propagation in optical fibers. Other examples of efficient methods are based on the photonic generation involving specific Mach-Zehnder modulators, microwave photonic filters as well as frequency-to-time conversion. In this contribution, we theoretically and experimentally demonstrate a new approach enabling the synthesis of periodic high-repetition rate pulses with various intensity profiles ranging from parabola to triangular and flat-top pulses. More precisely by linear phase and amplitude shaping of only four spectral lines is it possible to reach the targeted temporal profile. Indeed, tailoring the input symmetric spectrum only requires the determination of two physical parameters: the phase difference between the inner and outer spectral sidebands and the ratio between the amplitude of these sidebands. Therefore, a systematic bidimensional analysis provides the optimum parameters and also highlights that switching between the different waveforms is achieved by simply changing the spectral phase between the inner and outer sidebands. We successfully validate this concept with the generation of high-fidelity ultrafast periodic waveforms at 40 GHz by shaping with a liquid cristal on insulator a four sideband comb resulting from a phase-modulated continuous wave. In order to reach higher repetition rates, we also describe a new scenario to obtain the required initial spectrum by taking advantage of the four-wave mixing process occurring in a highly nonlinear fiber. This approach is experimentally implemented at a repetition rate of 80-GHz by use of intensity and phase measurements that stress that full-duty cycle, high-quality, triangular, parabolic or flat-top profiles are obtained in full agreement with numerical simulations. The reconfigurable property of this photonic waveform generator is confirmed. Finally, the generation of bunch of shaped pulses is investigated, as well as the impact of Brillouin backscattering.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bae, Soo Kyung; Gwak, Jungsug; Song, Im-Sook

Highlights: {yields} TopIn activates p53-dependent transcription in colon cancer cells. {yields} TopIn induces apoptosis in colon cancer cells. {yields} TopIn selectively inhibits topoisomerase I activity. {yields} TopIn does not affect the activity of BCRP and MDR-1. -- Abstract: The tumor suppressor p53 plays an important role in cellular emergency mechanisms through regulating the genes involved in cell cycle arrest and apoptosis. To identify small molecules that can activate p53-responsive transcription, we performed chemical screening using genetically engineered HCT116 reporter cells. We found that TopIn (7-phenyl-6H-[1,2,5]oxadiazolo[3,4-e]indole 3-oxide) efficiently activated p53-mediated transcriptional activity and induced phosphorylation of p53 at Ser15, thereby stabilizingmore » the p53 protein. Furthermore, TopIn upregulated the expression of p21{sup WAF1/CIP1}, a downstream target of p53, and suppressed cellular proliferation in various colon cancer cells. Additionally, TopIn induced DNA fragmentation, caspase-3/7 activation and poly ADP ribose polymerase cleavage, typical biochemical markers of apoptosis, in p53 wild-type and mutated colon cancer cells. Finally, we found that TopIn inhibited topoisomerase I activity, but not topoisomerase II, in vitro and induced the formation of the topoisomerase I-DNA complex in HCT116 colon cancer cells. Unlike camptothecin (CPT) and its derivative SN38, TopIn did not affect the activity of the ATP-binding cassette transporter breast cancer resistance protein (BCRP) or multidrug-resistant protein-1 (MDR-1). These results suggest that TopIn may present a promising new topoisomerase I-targeting anti-tumor therapeutics.« less

Trust in direct leaders and top leaders: A trickle-up model.

PubMed

Fulmer, C Ashley; Ostroff, Cheri

2017-04-01

Low levels of employee trust in top leaders pose challenges to organizations with respect to retention, performance, and profits. This research examines how trust in top leaders can be fostered through the relationships individuals have with their direct leaders. We propose a trickle-up model whereby trust in direct leaders exerts an upward influence on trust in top leaders. Drawing on the group value model, we predict that direct leaders' procedural justice serves as the key mechanism in facilitating the trickle-up process. Further, this process should be particularly strong for employees high on vertical collectivism, and the trickled-up trust in top leaders should exert a stronger impact on employees' overall performance in the organization than trust in direct leaders. Multiphase and multisource data from 336 individuals support these hypotheses. The findings advance our understanding of trust and leadership by highlighting that trust in leaders at different levels does not form independently and that trust in leaders trickles up across hierarchical levels. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Trade-Offs between the Top-Down and Bottom-Up School Education Management Models: The Implementation of School Development Planning in Western China

ERIC Educational Resources Information Center

Zhu, Zhiyong

2008-01-01

In the 1990s, numerous primary and secondary schools in China began experimental exploration and research on the implementation of school development planning (SDP). However, there has been a lack of self-criticism and reflection on the actual implementation situations and changes in SDP's concepts in the participating schools. This study assessed…

Race to the Top: Implementation and Relationship to Student Outcomes: Executive Summary. NCEE 2017-4000

ERIC Educational Resources Information Center

Dragoset, Lisa; Thomas, Jaime; Herrmann, Mariesa; Deke, John; James-Burdumy, Susanne; Graczewski, Cheryl; Boyle, Andrea; Tanenbaum, Courtney; Giffin, Jessica; Upton, Rachel

2016-01-01

Race to the Top (RTT), one of the Obama administration's signature programs and one of the largest federal government investments in an education grant program, received $4.35 billion in funding as part of the American Recovery and Reinvestment Act of 2009. Through three rounds of competition in 2010 and 2011, RTT awarded grants to states that…

Current and Future Education Leaders' Perceptions of Race to the Top's Teacher Evaluation and Compensation Components, before and after Implementation

ERIC Educational Resources Information Center

Smith, Orin; Windish, Daniel; Taylor, Rosemarye

2016-01-01

This longitudinal study examined the professional perceptions of educational leaders as to the fairness and impact of teacher evaluation and compensation reforms under Race to the Top. The study surveyed graduate students in education and educational leadership programs to assess changes in their perceptions from prior to RTTT implementation…

Volpe Center Annual Accomplishments: Advancing Transportation Innovation for the Public Good - January 2018

DOT National Transportation Integrated Search

2018-01-01

The Volpe Centers Annual Accomplishments highlights our best work of 2017 and illustrates the sustained impact of the Volpe Center in supporting the U.S. DOTs top priorities and strategic goals: safety, infrastructure, innovation, and accountab...

Warfighter Associate: Decision Aiding and Metrics for Mission Command

DTIC Science & Technology

2012-01-23

Distributions: highlights the Pareto Principle -- the top 20% of the mission-command staff is heavily involved in collaborations. • Our...developing “Command Web”, a web service to support thin- client functionality (Intelligent Presentation Services enables this) Thank you

Efficacy of Coaching Preschool Teachers to Manage Challenging Behavior

ERIC Educational Resources Information Center

Brock, Matthew E.; Beaman-Diglia, Lauren E.

2018-01-01

Many early educators cite behavior management as a top professional development need. Evidence-based practices exist to address severe challenging behavior, but promoting implementation of these practices remains a challenge. In this single-case design study, two preschool teachers received coaching focused on implementing three evidence-based…

High-Precision Differential Predictions for Top-Quark Pairs at the LHC

NASA Astrophysics Data System (ADS)

Czakon, Michal; Heymes, David; Mitov, Alexander

2016-02-01

We present the first complete next-to-next-to-leading order (NNLO) QCD predictions for differential distributions in the top-quark pair production process at the LHC. Our results are derived from a fully differential partonic Monte Carlo calculation with stable top quarks which involves no approximations beyond the fixed-order truncation of the perturbation series. The NNLO corrections improve the agreement between existing LHC measurements [V. Khachatryan et al. (CMS Collaboration), Eur. Phys. J. C 75, 542 (2015)] and standard model predictions for the top-quark transverse momentum distribution, thus helping alleviate one long-standing discrepancy. The shape of the top-quark pair invariant mass distribution turns out to be stable with respect to radiative corrections beyond NLO which increases the value of this observable as a place to search for physics beyond the standard model. The results presented here provide essential input for parton distribution function fits, implementation of higher-order effects in Monte Carlo generators, as well as top-quark mass and strong coupling determination.

High-Precision Differential Predictions for Top-Quark Pairs at the LHC.

PubMed

Czakon, Michal; Heymes, David; Mitov, Alexander

2016-02-26

We present the first complete next-to-next-to-leading order (NNLO) QCD predictions for differential distributions in the top-quark pair production process at the LHC. Our results are derived from a fully differential partonic Monte Carlo calculation with stable top quarks which involves no approximations beyond the fixed-order truncation of the perturbation series. The NNLO corrections improve the agreement between existing LHC measurements [V. Khachatryan et al. (CMS Collaboration), Eur. Phys. J. C 75, 542 (2015)] and standard model predictions for the top-quark transverse momentum distribution, thus helping alleviate one long-standing discrepancy. The shape of the top-quark pair invariant mass distribution turns out to be stable with respect to radiative corrections beyond NLO which increases the value of this observable as a place to search for physics beyond the standard model. The results presented here provide essential input for parton distribution function fits, implementation of higher-order effects in Monte Carlo generators, as well as top-quark mass and strong coupling determination.

Professional nurses' attitudes towards providing termination of pregnancy services in a tertiary hospital in the north west province of South Africa.

PubMed

Mokgethi, N E; Ehlers, V J; van der Merwe, M M

2006-03-01

The Choice on Termination of Pregnancy Act (no 92 of 1996) was implemented during 1997. This study attempted to investigate professional nurses' attitudes towards rendering termination of pregnancy (TOP) services at a tertiary hospital in the North West Province of South Africa. A quantitative descriptive research design was used to study professional nurses' attitudes towards providing TOP services. The research results, obtained from questionnaires completed by professional nurses, indicated that most professional nurses' attitudes included that women should be at least 16 years of age to access these services; women should not be able to access repeated TOPs; nurses would prefer to administer pills rather than to use vacuum aspirations; nurses should work in TOP services by choice only. TOP centers should have better equipment, more resources and more staff members. Nurses working in TOP services would appreciate receiving more support from their families, friends, managers and communities. Some professional nurses experienced guilt, depression, anxiety and religious conflicts as a result of providing TOP services. Despite the legalisation of TOPs, these services remained stigmatised. Professional nurses did not want to work in these services and also did not want to be associated with them.

Prioritizing critical success factors for reverse logistics implementation using fuzzy-TOPSIS methodology

NASA Astrophysics Data System (ADS)

Agrawal, Saurabh; Singh, Rajesh K.; Murtaza, Qasim

2016-03-01

Electronics industry is one of the fastest growing industries in the world. In India also, there are high turnovers and growing demand of electronics product especially after post liberalization in early nineties. These products generate e-waste which has become big environmental issue. Industries can handle these e-waste and product returns efficiently by developing reverse logistics (RL) system. A thorough study of critical success factors (CSFs) and their ordered implementation is essential for successful RL implementation. The aim of the study is to review the CSFs, and to prioritize them for RL implementation in Indian electronics industry. Twelve CSFs were identified through literature review, and discussion with the experts from the Indian electronics industry. Fuzzy-Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) approach is proposed for prioritizing these CSFs. Perusal of literature indicates that fuzzy-TOPSIS has not been applied earlier for prioritization of CSFs in Indian electronics industry. Five Indian electronics companies were selected for evaluation of this methodology. Results indicate that most of the identified factors are crucial for the RL implementation. Top management awareness, resource management, economic factors, and contracts terms and conditions are top four prioritized factor, and process capabilities and skilled workers is the least prioritized factor. The findings will be useful for successful RL implementation in Indian electronics industry.

Health care managers' views on and approaches to implementing models for improving care processes.

PubMed

Andreasson, Jörgen; Eriksson, Andrea; Dellve, Lotta

2016-03-01

To develop a deeper understanding of health-care managers' views on and approaches to the implementation of models for improving care processes. In health care, there are difficulties in implementing models for improving care processes that have been decided on by upper management. Leadership approaches to this implementation can affect the outcome. In-depth interviews with first- and second-line managers in Swedish hospitals were conducted and analysed using grounded theory. 'Coaching for participation' emerged as a central theme for managers in handling top-down initiated process development. The vertical approach in this coaching addresses how managers attempt to sustain unit integrity through adapting and translating orders from top management. The horizontal approach in the coaching refers to managers' strategies for motivating and engaging their employees in implementation work. Implementation models for improving care processes require a coaching leadership built on close manager-employee interaction, mindfulness regarding the pace of change at the unit level, managers with the competence to share responsibility with their teams and engaged employees with the competence to share responsibility for improving the care processes, and organisational structures that support process-oriented work. Implications for nursing management are the importance of giving nurse managers knowledge of change management. © 2015 John Wiley & Sons Ltd.

Internet Domain Names: Background and Policy Issues

DTIC Science & Technology

2010-04-05

was enacted to create a “ kids -friendly top level domain name” that would contain only age- appropriate content. The Dot Kids Implementation and...were introduced to require the Department of Commerce to compel ICANN to establish a mandatory top level domain name (such as . ) for material that...ICANN announced that it had entered into commercial and technical negotiations with a registry company (ICM Registry) to operate a new “. ” domain

A Robust Two-Dimensional Separation for Top-Down Tandem Mass Spectrometry of the Low-Mass Proteome

PubMed Central

Lee, Ji Eun; Kellie, John F.; Tran, John C.; Tipton, Jeremiah D.; Catherman, Adam D.; Thomas, Haylee M.; Ahlf, Dorothy R.; Durbin, Kenneth R.; Vellaichamy, Adaikkalam; Ntai, Ioanna; Marshall, Alan G.; Kelleher, Neil L.

2010-01-01

For fractionation of intact proteins by molecular weight (MW), a sharply improved two-dimensional (2D) separation is presented to drive reproducible and robust fractionation before top-down mass spectrometry of complex mixtures. The “GELFrEE” (i.e., gel-eluted liquid fraction entrapment electrophoresis) approach is implemented by use of Tris-glycine and Tris-tricine gel systems applied to human cytosolic and nuclear extracts from HeLa S3 cells, to achieve a MW-based fractionation of proteins from 5 to >100 kDa in 1 h. For top-down tandem mass spectroscopy (MS/MS) of the low-mass proteome (5–25 kDa), between 5 and 8 gel-elution (GE) fractions are sampled by nanocapillary-LC-MS/MS with 12 or 14.5 tesla Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometers. Single injections give about 40 detectable proteins, about half of which yield automated ProSight identifications. Reproducibility metrics of the system are presented, along with comparative analysis of protein targets in mitotic versus asynchronous cells. We forward this basic 2D approach to facilitate wider implementation of top-down mass spectrometry and a variety of other protein separation and/or characterization approaches. PMID:19747844

Dermatologic Features of Classic Movie Villains

PubMed Central

Reese, Vail; Wagner, Richard F.

2017-01-01

Importance Dichotomous dermatologic depictions of heroes and villains in movies have been used since the silent film age. Objective To evaluate the hero-villain skin dichotomy in film by (1) identifying dermatologic findings of the all-time top 10 American film villains, (2) comparing these dermatologic findings to the all-time top 10 American film heroes quantitatively and qualitatively, and (3) analyzing dermatologic portrayals of film villains in depth. Design, Setting, and Participants In this cross-sectional study, dermatologic findings for film heroes and villains in mainstream media were identified and compared quantitatively using a χ2 test with α < .05, as well as qualitatively. The all-time top 10 American film villains and heroes were obtained from the American Film Institute 100 Greatest Heroes and Villains List. Main Outcomes and Measures Primary outcomes include identification and frequencies of dermatologic findings of the top 10 film villains and of the top 10 film heroes. Results Six (60%) of the all-time top 10 American film villains have dermatologic findings, including cosmetically significant alopecia (30%), periorbital hyperpigmentation (30%), deep rhytides on the face (20%), multiple facial scars (20%), verruca vulgaris on the face (20%), and rhinophyma (10%). The top 10 villains have a higher incidence of significant dermatologic findings than the top 10 heroes (60% vs 0%; P = .03). Conclusions and Relevance Dermatologic findings of the all-time top 10 American villains are used in film to highlight the dichotomy of good and evil, which may foster a tendency toward prejudice in our society directed at those with skin disease. PMID:28384669

Effects of Top-Down and Bottom-Up Elementary School Standards Reform in an Underperforming California District

ERIC Educational Resources Information Center

Mason, Bryce; Mason, DeWayne A.; Mendez, Memo; Nelsen, Gregg; Orwig, Russ

2005-01-01

In this article we describe how an underperforming school district used research and theory on curriculum, assessment, implementation, and school and classroom organization to develop and implement district standards and improve the achievement of elementary school students. Key reforms included teachers developing essential curriculum standards,…

Classroom Modules for Nanotechnology Undergraduate Education: Development, Implementation and Evaluation

ERIC Educational Resources Information Center

Shabani, R.; Massi, L.; Zhai, L.; Seal, S.; Cho, H. J.

2011-01-01

In order to address the challenges and restrictions given by a traditional classroom lecture environment, the top-down and bottom-up nanotechnology teaching modules were developed, implemented and evaluated. Then based on the hypothesis that instructors could further develop students' interest in this emerging area through the introduction of the…

75 FR 64221 - Source Specific Federal Implementation Plan for Implementing Best Available Retrofit Technology...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-19

... combination of combustion and post-combustion controls. EPA approached the five factor analysis using a top... from fuel-bound nitrogen and high temperature combustion; (2) post- combustion add-on control to reduce... is a combination of a post- combustion add-on control, i.e., selective catalytic reduction (SCR), and...

Teachers' Agency, Efficacy, Engagement, and Emotional Resilience during Policy Innovation Implementation

ERIC Educational Resources Information Center

Wilcox, Kristen Campbell; Lawson, Hal A.

2018-01-01

This multiple case study investigated 143 teachers' responses to focus group questions about their experiences with the simultaneous implementation of three disruptive innovations as part of the U.S. Race-to-the-Top (RTTT) agenda: the Common Core Learning Standards, data-driven instruction, and annual professional performance reviews. We asked:…

Reforming the Japanese Preschool System: An Ethnographic Case Study of Policy Implementation

ERIC Educational Resources Information Center

Hayashi, Akiko; Tobin, Joseph

2017-01-01

This is an ethnographic study of how two Japanese kindergartens are implementing the "yohoichigenka" policy aimed at reforming the Japanese early childhood education system. The cases of these two kindergartens demonstrate what happens when a top-down mandate reaches the level of individual programs. The programs creatively find ways of…

Transitions in Classroom Technology: Instructor Implementation of Classroom Management Software

ERIC Educational Resources Information Center

Ackerman, David; Chung, Christina; Sun, Jerry Chih-Yuan

2014-01-01

The authors look at how business instructor needs are fulfilled by classroom management software (CMS), such as Moodle, and why instructors are sometimes slow to implement it. Instructors at different universities provided both qualitative and quantitative responses regarding their use of CMS. The results indicate that the top needs fulfilled by…

Implementing Marzano's Model: The Reality of Educational Leadership and School Reform

ERIC Educational Resources Information Center

Keaveny, Stacy M.

2013-01-01

Federal and state guidelines for school reform dominate the landscape of public education. Florida and its school districts, as a Race to the Top state, are in the process of fully implementing a value-added model of teacher evaluation. Effective school leaders are calling upon the theoretical framework of transformational, visionary and…

Top-down Proteomics: Technology Advancements and Applications to Heart Diseases

PubMed Central

Cai, Wenxuan; Tucholski, Trisha M.; Gregorich, Zachery R.; Ge, Ying

2016-01-01

Introduction Diseases of the heart are a leading cause of morbidity and mortality for both men and women worldwide, and impose significant economic burdens on the healthcare systems. Despite substantial effort over the last several decades, the molecular mechanisms underlying diseases of the heart remain poorly understood. Areas covered Altered protein post-translational modifications (PTMs) and protein isoform switching are increasingly recognized as important disease mechanisms. Top-down high-resolution mass spectrometry (MS)-based proteomics has emerged as the most powerful method for the comprehensive analysis of PTMs and protein isoforms. Here, we will review recent technology developments in the field of top-down proteomics, as well as highlight recent studies utilizing top-down proteomics to decipher the cardiac proteome for the understanding of the molecular mechanisms underlying diseases of the heart. Expert commentary Top-down proteomics is a premier method for the global and comprehensive study of protein isoforms and their PTMs, enabling the identification of novel protein isoforms and PTMs, characterization of sequence variations, and quantification of disease-associated alterations. Despite significant challenges, continuous development of top-down proteomics technology will greatly aid the dissection of the molecular mechanisms underlying diseases of the hearts for the identification of novel biomarkers and therapeutic targets. PMID:27448560

A to Z and In-between: New Magazines for Young Adults.

ERIC Educational Resources Information Center

Jones, Patrick

1994-01-01

Reviews magazines suitable for young adults. Highlights include considering appropriate demographics and/or local standards when selecting titles; top-selling magazines to middle school, high school, and public libraries; ordering information; adult magazines for consideration; tabloids; and "zines", or personal newsletters/small…

Physical principles for DNA tile self-assembly.

PubMed

Evans, Constantine G; Winfree, Erik

2017-06-19

DNA tiles provide a promising technique for assembling structures with nanoscale resolution through self-assembly by basic interactions rather than top-down assembly of individual structures. Tile systems can be programmed to grow based on logical rules, allowing for a small number of tile types to assemble large, complex assemblies that can retain nanoscale resolution. Such algorithmic systems can even assemble different structures using the same tiles, based on inputs that seed the growth. While programming and theoretical analysis of tile self-assembly often makes use of abstract logical models of growth, experimentally implemented systems are governed by nanoscale physical processes that can lead to very different behavior, more accurately modeled by taking into account the thermodynamics and kinetics of tile attachment and detachment in solution. This review discusses the relationships between more abstract and more physically realistic tile assembly models. A central concern is how consideration of model differences enables the design of tile systems that robustly exhibit the desired abstract behavior in realistic physical models and in experimental implementations. Conversely, we identify situations where self-assembly in abstract models can not be well-approximated by physically realistic models, putting constraints on physical relevance of the abstract models. To facilitate the discussion, we introduce a unified model of tile self-assembly that clarifies the relationships between several well-studied models in the literature. Throughout, we highlight open questions regarding the physical principles for DNA tile self-assembly.

Evaluation of a Fuel-Based Oil and Gas Inventory of Nitrogen Oxides with Top-Down Emissions

NASA Astrophysics Data System (ADS)

Mcdonald, B. C.; Gorchov Negron, A.; McKeen, S. A.; Peischl, J.; Gilman, J.; Ahmadov, R.; Frost, G. J.; Ryerson, T. B.; Thompson, C. R.; Trainer, M.

2017-12-01

Several studies have highlighted overestimates in anthropogenic emissions of nitrogen oxides (NOx) for the U.S., with particular attention on the mobile source sector. In this study, we explore whether there could be overestimates in the emissions of NOx from oil and gas production regions. We construct a bottom-up inventory using publicly available fuel use records of the industry and emission factors reported in the literature. We compare both the NEI 2011 and the fuel-based inventory with top-down emission fluxes derived by aircraft and ground-based field measurement campaigns by NOAA that occurred in 2012-13, including for basins located in Uintah, Haynesville, Marcellus, and Fayetteville. Compared to the top-down fluxes, the NEI overestimates NOx by a factor of 2 across the four basins. However, the discrepancies are not uniform, reflecting variability in oil and gas engine activity and NOx emission factors. We explore this variability with our fuel-based inventory and perform a Monte Carlo analysis to assess uncertainties in emissions. We find that on average the fuel-based inventory improves the agreement with the top-down emissions, and that the top-down emissions are within the uncertainties of our analysis.

The Teaching Gap

ERIC Educational Resources Information Center

Feldman, Sandra

2004-01-01

One of the most comprehensive studies to highlight the achievement gap between students in the United States and those in many other countries is the Third International Mathematics and Science Study (TIMSS). TIMSS showed that a handful of countries (with Japan near the top) consistently outperformed the others studied (including the United…

Programming Support Library (PSL). Users Manual.

DTIC Science & Technology

1978-05-01

which provides the tools to organize, implement, and control computer program develop- ment. This involves the support of the actual programming process...provides the tools toorganize, implement, and control computer program development. The system is designed specifically to support top-down development...Structured Programming are finding increasing application in the computing community. Structured programs are, however, difficult to write in

A Multicase Study: Exploring Human Resource Information System Implementation and Utilization in Multinational Corporations in Kenya

ERIC Educational Resources Information Center

Nzyoka Yongo, Cyd W.

2016-01-01

Implementation and utilization of human resource information system (HRIS) though a very desirable prospect for many organizations, still remains a daunting task for many. This has been daunting because of prohibitive costs, security risks, top management resistance, employee attitudes, and so forth. Trends globally show that, organizations that…

Diffusion of Courses with World Wide Web Features: Perceptions of Journalism and Mass Communication Program Administrators.

ERIC Educational Resources Information Center

Sutherland, Patrick J.

2003-01-01

Examines perceptions of top administrators concerning courses with Web features at Association of Schools of Journalism and Mass Communication (ASJMC) programs. Studies the imperatives and pressures to implement courses with Web features as well as resistances to implementation. Suggests that administrators perceive an extensive set of needs and…

Challenges of Implementing a Top-Down Curriculum Innovation in English Language Teaching: Perspectives of Form Iii English Language Teachers in Kenya

ERIC Educational Resources Information Center

Okoth, Teresa A.

2016-01-01

This study investigated the challenges Form III English language teachers face when implementing the revised integrated English language curriculum. A mixed-method descriptive design was used in Eldoret East SubCounty in Kenya. Data was collected through questionnaires, interviews and reflective conversations. Cluster, purposive and random…

Metaphors and Meaning: Principals' Perceptions of Teacher Evaluation Implementation

ERIC Educational Resources Information Center

Derrington, Mary Lynne

2013-01-01

This Southeastern state was awarded one of the first two Race to The Top (RTTT) grants the U. S. Department of Education funded. A key piece of the state's winning application was a legislative mandate to implement an intensive, quantitative, and accountability driven teacher evaluation system beginning with the 2011-2012 school year. The new law…

Automatic Polyp Detection via A Novel Unified Bottom-up and Top-down Saliency Approach.

PubMed

Yuan, Yixuan; Li, Dengwang; Meng, Max Q-H

2017-07-31

In this paper, we propose a novel automatic computer-aided method to detect polyps for colonoscopy videos. To find the perceptually and semantically meaningful salient polyp regions, we first segment images into multilevel superpixels. Each level corresponds to different sizes of superpixels. Rather than adopting hand-designed features to describe these superpixels in images, we employ sparse autoencoder (SAE) to learn discriminative features in an unsupervised way. Then a novel unified bottom-up and top-down saliency method is proposed to detect polyps. In the first stage, we propose a weak bottom-up (WBU) saliency map by fusing the contrast based saliency and object-center based saliency together. The contrast based saliency map highlights image parts that show different appearances compared with surrounding areas while the object-center based saliency map emphasizes the center of the salient object. In the second stage, a strong classifier with Multiple Kernel Boosting (MKB) is learned to calculate the strong top-down (STD) saliency map based on samples directly from the obtained multi-level WBU saliency maps. We finally integrate these two stage saliency maps from all levels together to highlight polyps. Experiment results achieve 0.818 recall for saliency calculation, validating the effectiveness of our method. Extensive experiments on public polyp datasets demonstrate that the proposed saliency algorithm performs favorably against state-of-the-art saliency methods to detect polyps.

Top predators negate the effect of mesopredators on prey physiology.

PubMed

Palacios, Maria M; Killen, Shaun S; Nadler, Lauren E; White, James R; McCormick, Mark I

2016-07-01

Predation theory and empirical evidence suggest that top predators benefit the survival of resource prey through the suppression of mesopredators. However, whether such behavioural suppression can also affect the physiology of resource prey has yet to be examined. Using a three-tier reef fish food web and intermittent-flow respirometry, our study examined changes in the metabolic rate of resource prey exposed to combinations of mesopredator and top predator cues. Under experimental conditions, the mesopredator (dottyback, Pseudochromis fuscus) continuously foraged and attacked resource prey (juveniles of the damselfish Pomacentrus amboinensis) triggering an increase in prey O2 uptake by 38 ± 12·9% (mean ± SE). The visual stimulus of a top predator (coral trout, Plectropomus leopardus) restricted the foraging activity of the mesopredator, indirectly allowing resource prey to minimize stress and maintain routine O2 uptake. Although not as strong as the effect of the top predator, the sight of a large non-predator species (thicklip wrasse, Hemigymnus melapterus) also reduced the impact of the mesopredator on prey metabolic rate. We conclude that lower trophic-level species can benefit physiologically from the presence of top predators through the behavioural suppression that top predators impose on mesopredators. By minimizing the energy spent on mesopredator avoidance and the associated stress response to mesopredator attacks, prey may be able to invest more energy in foraging and growth, highlighting the importance of the indirect, non-consumptive effects of top predators in marine food webs. © 2016 The Authors. Journal of Animal Ecology published by John Wiley & Sons Ltd on behalf of British Ecological Society.

Top predators affect the composition of naive protist communities, but only in their early-successional stage.

PubMed

Zander, Axel; Gravel, Dominique; Bersier, Louis-Félix; Gray, Sarah M

2016-02-01

Introduced top predators have the potential to disrupt community dynamics when prey species are naive to predation. The impact of introduced predators may also vary depending on the stage of community development. Early-succession communities are likely to have small-bodied and fast-growing species, but are not necessarily good at defending against predators. In contrast, late-succession communities are typically composed of larger-bodied species that are more predator resistant relative to small-bodied species. Yet, these aspects are greatly neglected in invasion studies. We therefore tested the effect of top predator presence on early- and late-succession communities that were either naive or non-naive to top predators. We used the aquatic community held within the leaves of Sarracenia purpurea. In North America, communities have experienced the S. purpurea top predator and are therefore non-naive. In Europe, this predator is not present and its niche has not been filled, making these communities top-predator naive. We collected early- and late-succession communities from two non-naive and two naive sites, which are climatically similar. We then conducted a common-garden experiment, with and without the presence of the top predator, in which we recorded changes in community composition, body size spectra, bacterial density, and respiration. We found that the top predator had no statistical effect on global measures of community structure and functioning. However, it significantly altered protist composition, but only in naive, early-succession communities, highlighting that the state of community development is important for understanding the impact of invasion.

Planning for Progress: States Reflect on Year One Implementation of ESSA

ERIC Educational Resources Information Center

Rentner, Diane Stark; Kober, Nancy; Frizzell, Matthew

2017-01-01

Based on a fall 2017 survey of officials from 45 state education agencies, this report highlights early state efforts to implement the Every Student Succeeds Act (ESSA). The report highlights states' views on ESSA's shift in control from the federal government to states and school districts regarding accountability and school improvement…

DNA Topoisomerase 1 Prevents R-loop Accumulation to Modulate Auxin-Regulated Root Development in Rice.

PubMed

Shafiq, Sarfraz; Chen, Chunli; Yang, Jing; Cheng, Lingling; Ma, Fei; Widemann, Emilie; Sun, Qianwen

2017-06-05

R-loop structures (RNA:DNA hybrids) have important functions in many biological processes, including transcriptional regulation and genome instability among diverse organisms. DNA topoisomerase 1 (TOP1), an essential manipulator of DNA topology during RNA transcription and DNA replication processes, can prevent R-loop accumulation by removing the positive and negative DNA supercoiling that is made by RNA polymerases during transcription. TOP1 is required for plant development, but little is known about its function in preventing co-transcriptional R-loop accumulation in various biological processes in plants. Here we show that knockdown of OsTOP1 strongly affects rice development, causing defects in root architecture and gravitropism, which are the consequences of misregulation of auxin signaling and transporter genes. We found that R-loops are naturally formed at rice auxin-related gene loci, and overaccumulate when OsTOP1 is knocked down or OsTOP1 protein activity is inhibited. OsTOP1 therefore sets the accurate expression levels of auxin-related genes by preventing the overaccumulation of inherent R-loops. Our data reveal R-loops as important factors in polar auxin transport and plant root development, and highlight that OsTOP1 functions as a key to link transcriptional R-loops with plant hormone signaling, provide new insights into transcriptional regulation of hormone signaling in plants. Copyright © 2017 The Author. Published by Elsevier Inc. All rights reserved.

Highlights from the Coordinating Research Council’s 2016 Air Quality Research Needs Workshop: Top 11 ResearchNeeds

EPA Science Inventory

The Coordinating Research Council (CRC) conducted an Air Quality Research Needs Workshop on February 9-10, 2016 at the Georgia Institute of Technology, in Atlanta, GA. The workshop brought together researchers from academia, government, and industry to brainstorm and prioritize ...

Returning Fire

ERIC Educational Resources Information Center

Gould, Jon B.

2007-01-01

Last December saw another predictable report from the Foundation for Individual Rights in Education (FIRE), a self-described watchdog group, highlighting how higher education is supposedly under siege from a politically correct plague of so-called hate-speech codes. In that report, FIRE declared that as many as 96 percent of top-ranked colleges…

Top Ten Trends in Enrollment Management. Synopsis: Higher Education Research Highlights.

ERIC Educational Resources Information Center

Wolff, Tracy L.; Bryant, Peter S.

This national survey of college and university enrollment management practices examines how current technology is being used to make enrollment management more efficient and cost-effective. The report finds that more enrollment managers use advanced tracking, research, and analysis systems to determine the most effective outreach methods; they…

No Room at the Top: Sex Discrimination in Higher Education.

ERIC Educational Resources Information Center

Sorgman, Margo

Data are presented on women in higher education, along with information on federal legislation to eliminate sex discrimination, issues concerning redressing employment discrimination, specific problems with legislative procedures and enforcement of legislation, and case studies that highlight some of the processes involved. Evidence is cited that…

Unique Challenges to (Federal) Enterprise Streaming

NASA Technical Reports Server (NTRS)

Walls, Bryan

2006-01-01

Enterprise streaming has different parameters than consumer Streaming. The government enterprise has some differences on top of that. I'd like to highlight some issues shared by the Federal government as a whole, with a closer look at streaming within NASA. Then we'll look at NASA's strategy for streaming.

A View from the Mountain Top: The Purple Mountain Observatory Library, China

ERIC Educational Resources Information Center

Zhang, Jian

2012-01-01

This paper discusses the author's experience directing the Purple Mountain Observatory Library, Chinese Academy of Sciences (CAS) in Nanjing, China. Routine collection development, management and preservation issues are described, and the unique challenges and opportunities involved in operating a remote observatory library are highlighted.

Blacks in Pop Music: A Short Story.

ERIC Educational Resources Information Center

Rickelman, Melinda

1991-01-01

A short history of black pop music includes artists who have changed pop music or culture and highlights from the 1920s into the 1980s, from Fats Waller to Michael Jackson. In black pop music, there is a direct line of influence from the sharecropper to the current Top 40. (SLD)

The scaling issue: scientific opportunities

NASA Astrophysics Data System (ADS)

Orbach, Raymond L.

2009-07-01

A brief history of the Leadership Computing Facility (LCF) initiative is presented, along with the importance of SciDAC to the initiative. The initiative led to the initiation of the Innovative and Novel Computational Impact on Theory and Experiment program (INCITE), open to all researchers in the US and abroad, and based solely on scientific merit through peer review, awarding sizeable allocations (typically millions of processor-hours per project). The development of the nation's LCFs has enabled available INCITE processor-hours to double roughly every eight months since its inception in 2004. The 'top ten' LCF accomplishments in 2009 illustrate the breadth of the scientific program, while the 75 million processor hours allocated to American business since 2006 highlight INCITE contributions to US competitiveness. The extrapolation of INCITE processor hours into the future brings new possibilities for many 'classic' scaling problems. Complex systems and atomic displacements to cracks are but two examples. However, even with increasing computational speeds, the development of theory, numerical representations, algorithms, and efficient implementation are required for substantial success, exhibiting the crucial role that SciDAC will play.

Process-Based Mission Assurance- Knowledge Management System

NASA Astrophysics Data System (ADS)

Kantzes, Zachary S.; Wander, Stephen; Otero, Suzanne; Vantine, William; Stuart, Richard

2005-12-01

The Process-Based Mission Assurance - Knowledge Management System (PBMA-KMS) implemented at the National Aeronautics and Space Administration (NASA) focuses on the practical application of the knowledge management (KM) theory and is based on a systems engineering management approach coupled to a continual improvement and risk management philosophy. Not to be confused with an Agency mandate, an intense focus has been placed on grassroots input to the future of the product. By providing emphasis to both Agency safety and mission success objectives and individual users' needs, the PBMA-KMS team has been able to be both reactive to Agency requirements and proactive to the needs of the community.PBMA-KMS is an excellent case study on how to use new approaches to facilitate and integrate safety into the culture of an organization. Principle discussion topics include: • Overarching themes,• Tactical approaches,• Highlights of key functionalities, and• Agency KM approach of managed Darwinism.PBMA-KMS can show how, by providing top-level guidance along with the necessary tools and support, the organization not only receives immediate value, but the long-ranging benefits of a more experienced, effective, and engaged workforce.

Race to the Top: States Implementing Teacher and Principal Evaluation Systems Despite Challenges. Report to the Chairman, Committee on Education and the Workforce, House of Representatives. GAO-13-777

ERIC Educational Resources Information Center

Scott, George A.

2013-01-01

The Department of Education (Education) created Race to The Top (RTT) under the American Recovery and Reinvestment Act of 2009 to provide incentives for states to reform K-12 education in areas such as improving the lowest performing schools and developing effective teachers and leaders. In 2010, Education awarded 12 states nearly $4 billion in…

Benchmarking Software Assurance Implementation

DTIC Science & Technology

2011-05-18

product The chicken#. (a.k.a. Process Focused Assessment ) – Management Systems ( ISO 9001, ISO 27001 , ISO 2000) – Capability Maturity Models (CMMI...Assurance PRM, RMM, Assurance for CMMI)) – Lifecycle Processes ( ISO /IEEE 15288, ISO /IEEE 12207) – COBIT, ITIL, MS SDL, OSAMM, BSIMM 5 The egg...a.k.a Product Focused Assessments) – SCAP - NIST-SCAP – ISO /OMG W3C – KDM, BPMN, RIF, XMI, RDF – OWASP Top 10 – SANS TOP 25 – Secure Code Check Lists

Pregnancy outcomes in prenatally diagnosed 47, XXX and 47, XYY syndromes: a 30-year French, retrospective, multicentre study.

PubMed

Gruchy, Nicolas; Blondeel, Eleonore; Le Meur, Nathalie; Joly-Hélas, Géraldine; Chambon, Pascal; Till, Marianne; Herbaux, Martine; Vigouroux-Castera, Adeline; Coussement, Aurélie; Lespinasse, James; Amblard, Florence; Jimenez Pocquet, Mélanie; Lebel-Roy, Camille; Carré-Pigeon, Frédérique; Flori, Elisabeth; Mugneret, Francine; Jaillard, Sylvie; Yardin, Catherine; Harbuz, Radu; Collonge-Rame, Marie-Agnès; Vago, Philippe; Valduga, Mylène; Leporrier, Nathalie; Vialard, François

2016-06-01

Sex chromosome aneuploidies are frequently detected fortuitously in a prenatal diagnosis. Most cases of 47, XXX and 47, XYY syndromes are diagnosed in this context, and parents are thus faced with an unexpected situation. The objective of the present study was to characterize a French cohort of prenatally diagnosed cases of 47, XXX and 47, XYY and to evaluate the termination of pregnancy (TOP) rate before and after France's implementation of multidisciplinary centres for prenatal diagnosis in 1997. This retrospective study identified respectively 291 and 175 cases of prenatally diagnosed 47, XXX and 47, XYY between 1976 and 2012. For each case, the indication, maternal age, karyotype and outcome were recorded. Most diagnoses of the two conditions were fortuitous. The occurrence of 47, XXX was associated with advanced maternal age. The overall TOP rate was higher for 47, XXX (22.9%) than for 47, XYY (14.6%), although this difference was not statistically significant. However, the TOP rates fell significantly after 1997 (from 41.1% to 11.8% for 47, XXX and from 25.8% to 6.7% for 47, XYY). The TOP rates after prenatal diagnoses of 47, XXX and 47, XYY fell significantly after 1997, following France's implementation of multidisciplinary centres for prenatal diagnosis. © 2016 John Wiley & Sons, Ltd. © 2016 John Wiley & Sons, Ltd.

Anything but engaged: user involvement in the context of a national electronic health record implementation.

PubMed

Cresswell, Kathrin; Morrison, Zoe; Crowe, Sarah; Robertson, Ann; Sheikh, Aziz

2011-01-01

The absence of meaningful end user engagement has repeatedly been highlighted as a key factor contributing to 'failed' implementations of electronic health records (EHRs), but achieving this is particularly challenging in the context of national scale initiatives. In 2002, the National Health Service (NHS) embarked on a so-called 'top-down' national implementation strategy aimed at introducing commercial, centrally procured, EHRs into hospitals throughout England. We aimed to examine approaches to, and experiences of, user engagement in the context of a large-scale EHR implementation across purposefully selected hospital care providers implementing early versions of nationally procured software. We conducted a qualitative, case-study based, socio-technically informed, longitudinal investigation, purposefully sampling and collecting data from four hospitals. Our data comprised a total of 123 semi-structured interviews with users and managers, 15 interviews with additional stakeholders, 43 hours of non-participant observations of meetings and system use, and relevant organisation-specific documents from each case study site. Analysis was thematic, building on an existing model of user engagement that was originally developed in the context of studying the implementation of relatively simple technologies in commercial settings. NVivo8 software was used to facilitate coding. Despite an enduring commitment to the vision of shared EHRs and an appreciation of their potential benefits, meaningful end user engagement was never achieved. Hospital staff were not consulted in systems choice, leading to frustration; they were then further alienated by the implementation of systems that they perceived as inadequately customised. Various efforts to achieve local engagement were attempted, but these were in effect risk mitigation strategies. We found the role of clinical champions to be important in these engagement efforts, but progress was hampered by the hierarchical structures within healthcare teams. As a result, engagement efforts focused mainly on clinical staff with inadequate consideration of management and administrative staff. This work has allowed us to further develop an existing model of user engagement from the commercial sector and adapt it to inform user engagement in the context of large-scale eHealth implementations. By identifying key points of possible engagement, disengagement and re-engagement, this model will we hope both help those planning similar large-scale EHR implementation efforts and act as a much needed catalyst to further research in this neglected field of enquiry.

Large-eddy Simulation of Stratocumulus-topped Atmospheric Boundary Layers with Dynamic Subgrid-scale Models

NASA Technical Reports Server (NTRS)

Senocak, Inane

2003-01-01

The objective of the present study is to evaluate the dynamic procedure in LES of stratocumulus topped atmospheric boundary layer and assess the relative importance of subgrid-scale modeling, cloud microphysics and radiation modeling on the predictions. The simulations will also be used to gain insight into the processes leading to cloud top entrainment instability and cloud breakup. In this report we document the governing equations, numerical schemes and physical models that are employed in the Goddard Cumulus Ensemble model (GCEM3D). We also present the subgrid-scale dynamic procedures that have been implemented in the GCEM3D code for the purpose of the present study.

Calibration of the Top-Quark Monte Carlo Mass.

PubMed

Kieseler, Jan; Lipka, Katerina; Moch, Sven-Olaf

2016-04-22

We present a method to establish, experimentally, the relation between the top-quark mass m_{t}^{MC} as implemented in Monte Carlo generators and the Lagrangian mass parameter m_{t} in a theoretically well-defined renormalization scheme. We propose a simultaneous fit of m_{t}^{MC} and an observable sensitive to m_{t}, which does not rely on any prior assumptions about the relation between m_{t} and m_{t}^{MC}. The measured observable is independent of m_{t}^{MC} and can be used subsequently for a determination of m_{t}. The analysis strategy is illustrated with examples for the extraction of m_{t} from inclusive and differential cross sections for hadroproduction of top quarks.

Challenges and Requirements for the Application of Industry 4.0: A Special Insight with the Usage of Cyber-Physical System

NASA Astrophysics Data System (ADS)

Mueller, Egon; Chen, Xiao-Li; Riedel, Ralph

2017-09-01

Considered as a top priority of industrial development, Industry 4.0 (or Industrie 4.0 as the German version) has being highlighted as the pursuit of both academy and practice in companies. In this paper, based on the review of state of art and also the state of practice in different countries, shortcomings have been revealed as the lacking of applicable framework for the implementation of Industrie 4.0. Therefore, in order to shed some light on the knowledge of the details, a reference architecture is developed, where four perspectives namely manufacturing process, devices, software and engineering have been highlighted. Moreover, with a view on the importance of Cyber-Physical systems, the structure of Cyber-Physical System are established for the in-depth analysis. Further cases with the usage of Cyber-Physical System are also arranged, which attempts to provide some implications to match the theoretical findings together with the experience of companies. In general, results of this paper could be useful for the extending on the theoretical understanding of Industrie 4.0. Additionally, applied framework and prototypes based on the usage of Cyber-Physical Systems are also potential to help companies to design the layout of sensor nets, to achieve coordination and controlling of smart machines, to realize synchronous production with systematic structure, and to extend the usage of information and communication technologies to the maintenance scheduling.

Top-Down Beta Enhances Bottom-Up Gamma

PubMed Central

Thompson, William H.

2017-01-01

Several recent studies have demonstrated that the bottom-up signaling of a visual stimulus is subserved by interareal gamma-band synchronization, whereas top-down influences are mediated by alpha-beta band synchronization. These processes may implement top-down control of stimulus processing if top-down and bottom-up mediating rhythms are coupled via cross-frequency interaction. To test this possibility, we investigated Granger-causal influences among awake macaque primary visual area V1, higher visual area V4, and parietal control area 7a during attentional task performance. Top-down 7a-to-V1 beta-band influences enhanced visually driven V1-to-V4 gamma-band influences. This enhancement was spatially specific and largest when beta-band activity preceded gamma-band activity by ∼0.1 s, suggesting a causal effect of top-down processes on bottom-up processes. We propose that this cross-frequency interaction mechanistically subserves the attentional control of stimulus selection. SIGNIFICANCE STATEMENT Contemporary research indicates that the alpha-beta frequency band underlies top-down control, whereas the gamma-band mediates bottom-up stimulus processing. This arrangement inspires an attractive hypothesis, which posits that top-down beta-band influences directly modulate bottom-up gamma band influences via cross-frequency interaction. We evaluate this hypothesis determining that beta-band top-down influences from parietal area 7a to visual area V1 are correlated with bottom-up gamma frequency influences from V1 to area V4, in a spatially specific manner, and that this correlation is maximal when top-down activity precedes bottom-up activity. These results show that for top-down processes such as spatial attention, elevated top-down beta-band influences directly enhance feedforward stimulus-induced gamma-band processing, leading to enhancement of the selected stimulus. PMID:28592697

Impact of oceanic submesoscale coherent structures on marine top predators: new tools and challenges

NASA Astrophysics Data System (ADS)

Tew-Kai, E.; Sudre, J.; Gremillet, D.; Yahia, H.; Rossi, V.; Hernandez-Garcia, E.; López, C.; Marsac, F.; Weimerskirch, H.; Garçon, V.

2011-12-01

In recent years it appears that meso- and submesoscale features (fronts, eddies, filaments) in surface ocean flow have a crucial influence on marine ecosystems. Their dynamics partly control the foraging behaviour and the movements of marine top. One of the challenges in ecology is to define critical habitats and understand the rules of habitat selection. Recently new tools for detection of coherent structures at submesoscale open the way for new studies never investigated before in marine ecology. Through two examples we highlight novel research on the importance of submesoscale structures for the spatial distribution of marine top predators. We studied two seabird populations with contrasting characteristics: Frigatebirds in the Mozambique Channel, and Cape gannets in the Benguela upwelling off southern Africa. Frigatebirds are mainly offshore birds while Cape gannets do not venture beyond the continental shelf. For these two studies, we used products derived from remote sensing data, to describe submesoscale coherent structures (<10km). In the first example, using Finite-Size Lyapunov Exponents (FSLE), we have identified Lagrangian coherent structures (LCSs) present in the surface flow of the Mozambique Channel resulting from an intense mesoscale activity. By comparing seabird satellite positions with LCSs locations, we demonstrate that frigatebirds track precisely these structures in the Mozambique Channel, providing the first evidence that a top predator is able to track these FSLE ridges to locate food patches. Although many questions remain unanswered, this work remains a pioneering on this topic. Despite the interest of FSLE, they are limited to offshore areas due to altimetry products limitation on continental shelves. However, many seabirds operate in coastal areas undergoing stronger anthropogenic pressures, such as Cape gannets off South Africa. The Benguela system is characterized by an upwelling inhabited by numerous fronts and filaments that very likely have a strong impact on seabird spatial distribution, and it was not possible to implement FSLE in this area. Thus, we used a newly developed method based on the singularity exponents calculated from remotely sensed data of ocean colour and SST, which delivers a precise picture of meso and submeso-scale structures off the coast. Preliminary results on understanding the rules of habitat selection by Cape gannets, and contribution to the conservation of this endangered species will be presented.

The State of Teacher Evaluation Reform: State Education Agency Capacity and the Implementation of New Teacher-Evaluation Systems

ERIC Educational Resources Information Center

McGuinn, Patrick

2012-01-01

The Obama administration's Race to the Top competitive grant program initiated an unprecedented wave of state teacher-evaluation reform across the country. To date, most of the scholarly analysis of this activity has focused on the design of the evaluation instruments or the implementation of the new evaluations by districts and schools. But…

Evaluation of Teachers and Leaders. State Implementation of College- and Career-Readiness Standards

ERIC Educational Resources Information Center

Anderson, Kimberly; Mira, Mary Elizabeth

2015-01-01

By 2012, all of the states in this study had started implementing new or revised teacher and leader evaluation systems. The systems include many and varying updates. In some cases, the updates were designed to meet conditions for a state's "Race to the Top" grant. In others, the updates were made to meet conditions for a state's waiver…

Sermons, Carrots or Sticks? Explaining Successful Policy Implementation in a Low Performance Institution

ERIC Educational Resources Information Center

Salazar-Morales, Diego Alonso

2018-01-01

This article explains how after 43 years of unsatisfactory outcomes, the Ministry of Education of Peru (MoE) suddenly ranked at the top of governmental performance tables. To do so, this study relies on implementation and major discussions of policy instrument theories to provide a comprehensive explanation of the reasons underlying the MoE's…

Evaluating Progress: State Education Agencies and the Implementation of New Teacher Evaluation Systems. WP #2015-09

ERIC Educational Resources Information Center

McGuinn, Patrick

2015-01-01

In a 2012 paper for the Center for American Progress, "The State of Evaluation Reform," Patrick McGuinn (Drew University) identified the opportunities and challenges facing education agencies in Race to the Top (RTTT) grant-winning states as they prepared for the implementation of new teacher evaluation systems. The 2012 study undertook…

Magnetic turbulence in a table-top laser-plasma relevant to astrophysical scenarios

NASA Astrophysics Data System (ADS)

Chatterjee, Gourab; Schoeffler, Kevin M.; Kumar Singh, Prashant; Adak, Amitava; Lad, Amit D.; Sengupta, Sudip; Kaw, Predhiman; Silva, Luis O.; Das, Amita; Kumar, G. Ravindra

2017-06-01

Turbulent magnetic fields abound in nature, pervading astrophysical, solar, terrestrial and laboratory plasmas. Understanding the ubiquity of magnetic turbulence and its role in the universe is an outstanding scientific challenge. Here, we report on the transition of magnetic turbulence from an initially electron-driven regime to one dominated by ion-magnetization in a laboratory plasma produced by an intense, table-top laser. Our observations at the magnetized ion scale of the saturated turbulent spectrum bear a striking resemblance with spacecraft measurements of the solar wind magnetic-field spectrum, including the emergence of a spectral kink. Despite originating from diverse energy injection sources (namely, electrons in the laboratory experiment and ion free-energy sources in the solar wind), the turbulent spectra exhibit remarkable parallels. This demonstrates the independence of turbulent spectral properties from the driving source of the turbulence and highlights the potential of small-scale, table-top laboratory experiments for investigating turbulence in astrophysical environments.

Resummed Differential Cross Sections for Top-Quark Pairs at the LHC.

PubMed

Pecjak, Benjamin D; Scott, Darren J; Wang, Xing; Yang, Li Lin

2016-05-20

We present state of the art resummation predictions for differential cross sections in top-quark pair production at the LHC. They are derived from a formalism which allows the simultaneous resummation of both soft and small-mass logarithms, which endanger the convergence of fixed-order perturbative series in the boosted regime, where the partonic center-of-mass energy is much larger than the mass to the top quark. We combine such a double resummation at next-to-next-to-leading logarithmic^{'} (NNLL^{'}) accuracy with standard soft-gluon resummation at next-to-next-to-leading logarithmic accuracy and with next-to-leading-order calculations, so that our results are applicable throughout the whole phase space. We find that the resummation effects on the differential distributions are significant, bringing theoretical predictions into better agreement with experimental data compared to fixed-order calculations. Moreover, such effects are not well described by the next-to-next-to-leading-order approximation of the resummation formula, especially in the high-energy tails of the distributions, highlighting the importance of all-orders resummation in dedicated studies of boosted top production.

Toward full exploitation of coherent and incoherent information in Sentinel-1 TOPS data for retrieving surface displacement: Application to the 2016 Kumamoto (Japan) earthquake

NASA Astrophysics Data System (ADS)

Jiang, Houjun; Feng, Guangcai; Wang, Teng; Bürgmann, Roland

2017-02-01

Sentinel-1's continuous observation program over all major plate boundary regions makes it well suited for earthquake studies. However, decorrelation due to large displacement gradients and limited azimuth resolution of the Terrain Observation by Progressive Scan (TOPS) data challenge acquiring measurements in the near field of many earthquake ruptures and prevent measurements of displacements in the along-track direction. Here we propose to fully exploit the coherent and incoherent information of TOPS data by using standard interferometric synthetic aperture radar (InSAR), split-bandwidth interferometry in range and azimuth, swath/burst-overlap interferometry, and amplitude cross correlation to map displacements in both the line-of-sight and the along-track directions. Application to the 2016 Kumamoto earthquake sequence reveals the coseismic displacements from the far field to the near field. By adding near-field constraints, the derived slip model reveals more shallow slip than obtained when only using far-field data from InSAR, highlighting the importance of exploiting all coherent and incoherent information in TOPS data.

Halal Logistics Implementation in Malaysia: A Practical View

NASA Astrophysics Data System (ADS)

Sham, Rohana; Zuraidah Rasi, Raja; Abdamia, Noranita; Mohamed, Suhana; Thahira Bibi, TKM

2017-08-01

Concept of halal is not only acceptable world wide by the Muslim society but also to the non Muslim. However, the implementing of halal logistics in daily operation experience a few difficulties especially on the implementation part. Although there are many academic research paper that highlight the issue of halal logistics and the critical success factor, until today, halal logistics in Malaysia is still experiencing a hiccup. This paper try to highlight a few simple ways of implementation of halal logistics that could enhance the total implementation concept at the very least cost to create benefit to all society. The Paper deals with a few aspect of possible implementation and practice to facilitate the halal logistics approach in daily operation. The main objective is to look at the possible method of implementation and critical success factors towards the implementation of halal logistics operation in daily goods movement in Malaysia.

Automated Discovery of Simulation Between Programs

DTIC Science & Technology

2014-10-18

relation. These relations enable the refinement-step of SimAbs. We have implemented SimAbs using UFO framework and Z3 SMT-solver and applied it to...step of SimAbs. We implemented SimAbs and AE-VAL on the top of the UFO framework [1, 15] and an SMT-solver Z3 [8], respectively. We have evaluated SimAbs...ut 6 Evaluation We have implemented SimAbs in the UFO framework, and evaluated it on the Software Verification Competition (SVCOMP’14) benchmarks and

A Web-based, secure, light weight clinical multimedia data capture and display system.

PubMed

Wang, S S; Starren, J

2000-01-01

Computer-based patient records are traditionally composed of textual data. Integration of multimedia data has been historically slow. Multimedia data such as image, audio, and video have been traditionally more difficult to handle. An implementation of a clinical system for multimedia data is discussed. The system implementation uses Java, Secure Socket Layer (SSL), and Oracle 8i. The system is on top of the Internet so it is architectural independent, cross-platform, cross-vendor, and secure. Design and implementations issues are discussed.

[How management teams use information and control systems to manage hospitals].

PubMed

Naranjo-Gil, David

2016-01-01

To analyze the relationship between the characteristics of top management teams and the different use of management information and control systems (MICS) to implement policies that encourage cooperation and activity coordination in public hospitals. Data were collected through a questionnaire sent to each member of the top management teams of 231 Spanish public hospitals (chief executive director, medical director, nursing director and director for financial and social issues). A total of 457 valid questionnaires were returned, composing 86 full top management teams (37.23%). Top management team diversity was positively related to the interactive use of MICS. Management teams composed of younger members and members with longer service used MICS interactively. Top management teams with a predominantly clinical education and experience used MICS interactively, while top teams with a predominantly administrative education and experience used MICS diagnostically. The results also showed that cooperation and coordination in hospitals were positively related to the interactive use of MICS and were negatively related to the diagnostic use of MICS. The interactive use of MICS is an important mediator in the relationship between top team diversity and policies focused on hospital decentralization. Top management teams with diverse characteristics (e.g. age, length of service, education and experience) use management information interactively to enhance activity coordination and resource allocation in hospitals. Copyright © 2016 SESPAS. Published by Elsevier Espana. All rights reserved.

Differential top-antitop cross-section measurements as a function of observables constructed from final-state particles using pp collisions at $$\\sqrt{s}=7 $$ TeV in the ATLAS detector

DOE PAGES

Aad, G.; Abbott, B.; Abdallah, J.; ...

2015-06-16

Various differential cross-sections are measured in top-quark pair (tt) events produced in proton-proton collisions at a centre-of-mass energy of √s = 7 TeV at the LHC with the ATLAS detect or. These differential cross-sections are presented in a data set corresponding to an integrated luminosity of 4.6 fb -1 . The differential cross-sections are presented in terms of kinematic variables, such as momentum, rapidity and invariant mass, of a top-quark proxy referred to as the pseudo-top-quark as well as the pseudo-top-quark pair system. The dependence of the measurement on theoretical models is minimal. The measurements are performed on tt eventsmore » in the lepton+jets channel, requiring exactly one charged lepton and at least four jets with at least two of them tagged as originating from a b-quark. The hadronic and leptonic pseudo-top-quarks are defined via the leptonic or hadronic decay mode of the W boson produced by the top-quark decay in events with a single charged lepton. Differential cross-section measurements of the pseudo-top-quark variables are compared with several Monte Carlo models that implement next-to-leading order or leading-order multi-leg matrix-element calculations.« less

Analysis of cloud top height and cloud coverage from satellites using the O2 A and B bands

NASA Technical Reports Server (NTRS)

Kuze, Akihiko; Chance, Kelly V.

1994-01-01

Cloud height and cloud coverage detection are important for total ozone retrieval using ultraviolet and visible scattered light. Use of the O2 A and B bands, around 761 and 687 nm, by a satellite-borne instrument of moderately high spectral resolution viewing in the nadir makes it possible to detect cloud top height and related parameters, including fractional coverage. The measured values of a satellite-borne spectrometer are convolutions of the instrument slit function and the atmospheric transmittance between cloud top and satellite. Studies here determine the optical depth between a satellite orbit and the Earth or cloud top height to high accuracy using FASCODE 3. Cloud top height and a cloud coverage parameter are determined by least squares fitting to calculated radiance ratios in the oxygen bands. A grid search method is used to search the parameter space of cloud top height and the coverage parameter to minimize an appropriate sum of squares of deviations. For this search, nonlinearity of the atmospheric transmittance (i.e., leverage based on varying amounts of saturation in the absorption spectrum) is important for distinguishing between cloud top height and fractional coverage. Using the above-mentioned method, an operational cloud detection algorithm which uses minimal computation time can be implemented.

A Measurement of the Top Quark Mass with the D0 Detector at s**(1/2) = 1.96-TeV using the Matrix Element Method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kroeninger, Kevin Alexander; /Bonn U.

2004-04-01

Using a data set of 158 and 169 pb{sup -1} of D0 Run-II data in the electron and muon plus jets channel, respectively, the top quark mass has been measured using the Matrix Element Method. The method and its implementation are described. Its performance is studied in Monte Carlo using ensemble tests and the method is applied to the Moriond 2004 data set.

Validation of Satellite-Based Objective Overshooting Cloud-Top Detection Methods Using CloudSat Cloud Profiling Radar Observations

NASA Technical Reports Server (NTRS)

Bedka, Kristopher M.; Dworak, Richard; Brunner, Jason; Feltz, Wayne

2012-01-01

Two satellite infrared-based overshooting convective cloud-top (OT) detection methods have recently been described in the literature: 1) the 11-mm infrared window channel texture (IRW texture) method, which uses IRW channel brightness temperature (BT) spatial gradients and thresholds, and 2) the water vapor minus IRW BT difference (WV-IRW BTD). While both methods show good performance in published case study examples, it is important to quantitatively validate these methods relative to overshooting top events across the globe. Unfortunately, no overshooting top database currently exists that could be used in such study. This study examines National Aeronautics and Space Administration CloudSat Cloud Profiling Radar data to develop an OT detection validation database that is used to evaluate the IRW-texture and WV-IRW BTD OT detection methods. CloudSat data were manually examined over a 1.5-yr period to identify cases in which the cloud top penetrates above the tropopause height defined by a numerical weather prediction model and the surrounding cirrus anvil cloud top, producing 111 confirmed overshooting top events. When applied to Moderate Resolution Imaging Spectroradiometer (MODIS)-based Geostationary Operational Environmental Satellite-R Series (GOES-R) Advanced Baseline Imager proxy data, the IRW-texture (WV-IRW BTD) method offered a 76% (96%) probability of OT detection (POD) and 16% (81%) false-alarm ratio. Case study examples show that WV-IRW BTD.0 K identifies much of the deep convective cloud top, while the IRW-texture method focuses only on regions with a spatial scale near that of commonly observed OTs. The POD decreases by 20% when IRW-texture is applied to current geostationary imager data, highlighting the importance of imager spatial resolution for observing and detecting OT regions.

MicroRNA-139 suppresses proliferation in luminal type breast cancer cells by targeting Topoisomerase II alpha

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hua, Wei; State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, 710032 Xi'an; Sa, Ke-Di

The classification of molecular subtypes of breast cancer improves the prognostic accuracy and therapeutic benefits in clinic. However, because of the complexity of breast cancer, more biomarkers and functional molecules need to be explored. Here, analyzing the data in a huge cohort of breast cancer patients, we found that Topoisomerase II alpha (TOP2a), an important target of chemotherapy is a biomarker for prognosis in luminal type breast cancer patients, but not in basal like or HER2 positive breast cancer patients. We identified that miR-139, a previous reported anti-metastatic microRNA targets 3’-untranslated region (3′UTR) of TOP2a mRNA. Further more, we revealedmore » that the forced expression of miR-139 reduces the TOP2a expression at both mRNA and protein levels. And our functional experiments showed that the ectopic expression of miR-139 remarkably inhibits proliferation in luminal type breast cancer cells, while exogenous TOP2a expression could rescue inhibition of cell proliferation mediated by miR-139. Collectively, our present study demonstrates the miR-139-TOP2a regulatory axis is important for proliferation in luminal type breast cancer cells. This functional link may help us to further understand the specificity of subtypes of breast cancer and optimize the strategy of cancer treatment. - Highlights: • High levels of TOP2a expression are closely associated with poor prognosis in luminal type breast cancer patients. • TOP2a is a novel target of miR-139. • Overexpression of miR-139 inhibits proliferation in luminal type breast cancer cells. • TOP2a is essential for miR-139-induced growth arrest in luminal type breast cancer cells.« less

Paying Your Way to the Top: Search Engine Advertising.

ERIC Educational Resources Information Center

Scott, David M.

2003-01-01

Explains how organizations can buy listings on major Web search engines, making it the fastest growing form of advertising. Highlights include two network models, Google and Overture; bidding on phrases to buy as links to use with ads; ad ranking; benefits for small businesses; and paid listings versus regular search results. (LRW)

Bridging Behavioral Assessment and Behavioral Intervention: Finding Your Inner Behavior Analyst

ERIC Educational Resources Information Center

Johnson, LeAnne D.; Monn, Emily

2015-01-01

The persistence of challenging behaviors for some children highlights a need and an opportunity to explore several key principles of behavioral intervention that are necessary for effective decision- making when more personalized interventions must be layered on top of high-quality universal supports. In the absence of expert support,…

Community College of Rhode Island: Annual Report, 1997.

ERIC Educational Resources Information Center

Abood, Nancy V.; LeBlanc, William; Racca, Susanne M.

This 1997 annual report describes major initiatives and outcomes for students, programs, faculty and staff, and finances at Community College of Rhode Island (CCRI). Highlighted are some of the steps the college has taken to address its priorities in meeting modern challenges. A message from the president reviews four top priorities for 1997,…

Elliptical Orbit [arrow right] 1/r[superscript 2] Force

ERIC Educational Resources Information Center

Prentis, Jeffrey; Fulton, Bryan; Hesse, Carol; Mazzino, Laura

2007-01-01

Newton's proof of the connection between elliptical orbits and inverse-square forces ranks among the "top ten" calculations in the history of science. This time-honored calculation is a highlight in an upper-level mechanics course. It would be worthwhile if students in introductory physics could prove the relation "elliptical orbit" [arrow right]…

High-light acclimation in Quercus robur L.seedlings upon over-topped a shaded environment

Treesearch

Anna M. Jensen; Emile S. Gardiner; Kevin C. Vaughn

2012-01-01

High developmental plasticity at the seedling-level during acclimation to the light environment may be an important determinant of seedling establishment and growth in temperate broadleaf forests, especially in dense understories where spatial light availability can vary greatly. Pedunculate oak (Quercus robur L.) seedlings were raised beneath a...

An interagency space nuclear propulsion safety policy for SEI - Issues and discussion

NASA Technical Reports Server (NTRS)

Marshall, A. C.; Sawyer, J. C., Jr.

1991-01-01

An interagency Nuclear Safety Policy Working Group (NSPWG) was chartered to recommend nuclear safety policy, requirements, and guidelines for the Space Exploration Initiative nuclear propulsion program to facilitate the implementation of mission planning and conceptual design studies. The NSPWG developed a top level policy to provide the guiding principles for the development and implementation of the nuclear propulsion safety program and the development of Safety Functional Requirements. In addition, the NSPWG reviewed safety issues for nuclear propulsion and recommended top level safety requirements and guidelines to address these issues. Safety topics include reactor start-up, inadvertent criticality, radiological release and exposure, disposal, entry, safeguards, risk/reliability, operational safety, ground testing, and other considerations. In this paper the emphasis is placed on the safety policy and the issues and considerations that are addressed by the NSPWG recommendations.

NSPWG-recommended safety requirements and guidelines for SEI nuclear propulsion

NASA Technical Reports Server (NTRS)

Marshall, Albert C.; Sawyer, J. C., Jr.; Bari, Robert A.; Brown, Neil W.; Cullingford, Hatice S.; Hardy, Alva C.; Lee, James H.; Mcculloch, William H.; Niederauer, George F.; Remp, Kerry

1992-01-01

An interagency Nuclear Safety Policy Working Group (NSPWG) was chartered to recommend nuclear safety policy, requirements, and guidelines for the Space Exploration Initiative (SEI) nuclear propulsion program to facilitate the implementation of mission planning and conceptual design studies. The NSPWG developed a top-level policy to provide the guiding principles for the development and implementation of the nuclear propulsion safety program and the development of safety functional requirements. In addition, the NSPWG reviewed safety issues for nuclear propulsion and recommended top-level safety requirements and guidelines to address these issues. Safety requirements were developed for reactor start-up, inadvertent criticality, radiological release and exposure, disposal, entry, and safeguards. Guidelines were recommended for risk/reliability, operational safety, flight trajectory and mission abort, space debris and meteoroids, and ground test safety. In this paper the specific requirements and guidelines will be discussed.

Experimental Pressure Distributions on Axisymmetric Cowls at Mach Numbers From 0.60 to 0.92

NASA Technical Reports Server (NTRS)

Re, Richard J.

2006-01-01

Pressure distributions on four nacelle cowl models of the same length and highlight area but different geometries external to the highlight are compared. The diameter ratio (ratio of highlight diameter to maximum diameter) of the four cowls was 0.854 and the length ratio (ratio of cowl length to maximum diameter) was 0.439. The cowls had the same internal geometry from the highlight to the throat with a contraction ratio (ratio of highlight area to throat area) of 1.250. Data for two other cowls which had a diameter ratio of 0.880, a length ratio of 0.400 and a contraction ratio 1.250 are also included. All the cowls had rows of static pressure orifices on the top and bottom surfaces. Mass-flow ratio was varied between 0.27 and 0.93. Some data were obtained between angles of attack from -2.1deg and 4.1deg. The test was conducted in the Langley 16-Foot Transonic Tunnel.

Broadband set-top box using MAP-CA processor

NASA Astrophysics Data System (ADS)

Bush, John E.; Lee, Woobin; Basoglu, Chris

2001-12-01

Advances in broadband access are expected to exert a profound impact in our everyday life. It will be the key to the digital convergence of communication, computer and consumer equipment. A common thread that facilitates this convergence comprises digital media and Internet. To address this market, Equator Technologies, Inc., is developing the Dolphin broadband set-top box reference platform using its MAP-CA Broadband Signal ProcessorT chip. The Dolphin reference platform is a universal media platform for display and presentation of digital contents on end-user entertainment systems. The objective of the Dolphin reference platform is to provide a complete set-top box system based on the MAP-CA processor. It includes all the necessary hardware and software components for the emerging broadcast and the broadband digital media market based on IP protocols. Such reference design requires a broadband Internet access and high-performance digital signal processing. By using the MAP-CA processor, the Dolphin reference platform is completely programmable, allowing various codecs to be implemented in software, such as MPEG-2, MPEG-4, H.263 and proprietary codecs. The software implementation also enables field upgrades to keep pace with evolving technology and industry demands.

Evaluation of Teachers and Leaders. State Implementation of Common Core State Standards

ERIC Educational Resources Information Center

Anderson, Kimberly; Mira, Mary Elizabeth

2014-01-01

By 2012, all of the states in this study had started implementing new or revised teacher and leader evaluation systems. There are many and varying updates to these systems, and some of them have been made to meet conditions for a state's federal "Race to the Top" (RTT) grant. Other updates have been made to meet conditions for a state's…

On the Frontline of CCSS Implementation: A National Study of Factors Influencing Teachers' Perceptions of Teaching Conditions and Job Satisfaction

ERIC Educational Resources Information Center

Endacott, Jason L.; Collet, Vicki; Goering, Christian Z.; Turner, Ronna; Denny, George S.; Wright, Ginney; Jennings-Davis, Jennifer

2016-01-01

The Common Core State Standards (CCSS) represent an unprecedented change in American education. As an increasingly integral part of the school accountability movement under No Child Left Behind and Race to the Top, responsibility for implementing CCSS rests largely with school leadership. One important factor in the success or failure of these…

Basomedial amygdala mediates top-down control of anxiety and fear.

PubMed

Adhikari, Avishek; Lerner, Talia N; Finkelstein, Joel; Pak, Sally; Jennings, Joshua H; Davidson, Thomas J; Ferenczi, Emily; Gunaydin, Lisa A; Mirzabekov, Julie J; Ye, Li; Kim, Sung-Yon; Lei, Anna; Deisseroth, Karl

2015-11-12

Anxiety-related conditions are among the most difficult neuropsychiatric diseases to treat pharmacologically, but respond to cognitive therapies. There has therefore been interest in identifying relevant top-down pathways from cognitive control regions in medial prefrontal cortex (mPFC). Identification of such pathways could contribute to our understanding of the cognitive regulation of affect, and provide pathways for intervention. Previous studies have suggested that dorsal and ventral mPFC subregions exert opposing effects on fear, as do subregions of other structures. However, precise causal targets for top-down connections among these diverse possibilities have not been established. Here we show that the basomedial amygdala (BMA) represents the major target of ventral mPFC in amygdala in mice. Moreover, BMA neurons differentiate safe and aversive environments, and BMA activation decreases fear-related freezing and high-anxiety states. Lastly, we show that the ventral mPFC-BMA projection implements top-down control of anxiety state and learned freezing, both at baseline and in stress-induced anxiety, defining a broadly relevant new top-down behavioural regulation pathway.

Cancer cachexia: global awareness and guideline implementation on the web.

PubMed

Mauri, Davide; Tsiara, Anna; Valachis, Antonis; Kalopita, Konstantina; Tsali, Lampriani; Tolis, Panagiotis; Polyzos, Nikolaos P

2013-06-01

Cancer cachexia is a common associate of cancer and has a negative impact on patients' survival. Nonetheless, cancer cachexia assessment and management are frequently less than satisfactory in daily practice. To scrutinise global cancer cachexia awareness and relative web guideline implementation among oncology societies. Systematical identification of scientific and policymaker oncology societies and their guideline implementation on cancer cachexia. Assessment of the general level of awareness on cancer cachexia and evaluation of intercontinental and national variations on guideline implementation. 144,000 web pages were scrutinised, and 275 oncology societies identified covering a large array of oncology setting (educational/clinical/research/policymaker); 71 were international (African, American, Asian, European, Oceania and Intercontinental), 110 belonged to the top 10 countries with the highest development index and 94 pertained to 10 countries with a long lasting tradition in medical oncology (not included in the top 10 high developed countries). Overall, only 10/275 web sites provided guidelines; six of them (2.2%) provided guidelines for physicians and four (0.7%) for patients. Half of the guidelines (4/10) were outdated. All guidelines for physicians reported references, while only one of the recommendations for patients reported references to support its sentences. Cancer cachexia global awareness appears extremely low; guideline implementation on the web was inconsistent for any category analysed (nation vs continent vs international vs society type vs physician vs patient oriented) and for updating.

The Northland fluoridation advocacy programme: an evaluation.

PubMed

Gowda, Sunitha; Thomas, David R

2008-12-01

On 20 July 2006, the Far North District Council resolved to fluoridate Kaitaia and Kaikohe. This was the first such initiative by any Territorial Local Authority (TLA) in New Zealand for 23 years, and resulted from a fluoridation advocacy programme. This paper describes the programme implementation, assesses its consistency with the principles of the Treaty of Waitangi, and critically examines the collaboration between the fluoride advocate and the key stakeholders. Process evaluation identified three main categories of programme implementation: policy advocacy, community action projects, and media advocacy. The collaboration of iwi, Maori health providers and the community suggests that the programme was consistent with the principles (partnership, participation and protection) ofthe Treaty ofWaitangi. Media advocacy played an important role in reflecting and engaging community views on fluoridation, and it influenced decision-making by the Far North District Council. The simultaneous, combined 'top-down and bottom-up' approach was an effective and successful strategy for fluoridation advocacy in the community. Less integrated approaches implemented on their own (such as the 'top down' approach in Whangarei and the 'bottom-up' approach in Dargaville) were not effective.

Alaska CVISN level one : top level design

DOT National Transportation Integrated Search

2000-06-02

Within the context of the National ITS Architecture, the Commercial Vehicle Information Systems Networks Program or CVISN is a dynamic program with flexible components and operating topologies, capable of adopting and implementing new and different c...

77 FR 38042 - TRICARE; Implementation of TRICARE Transitional Outpatient Payments

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-26

... amounts using a method similar to Medicare. TRICARE will pay an amount equal to 85 percent of the... TRICARE TOPs provision. The Patient Protection and Affordable Care Act (PPACA) extended the hold harmless...

A discussion of approaches to transforming care: contemporary strategies to improve patient safety.

PubMed

Burston, Sarah; Chaboyer, Wendy; Wallis, Marianne; Stanfield, Jane

2011-11-01

This article presents a discussion of three contemporary approaches to transforming care: Transforming Care at the Bedside, Releasing Time to Care: the Productive Ward and the work of the Studer Group(®). International studies of adverse events in hospitals have highlighted the need to focus on patient safety. The case for transformational change was identified and recently several approaches have been developed to effect this change. Despite limited evaluation, these approaches have spread and have been adopted outside their country of origin and contextual settings. Medline and CINAHL databases were searched for the years 1999-2009. Search terms included derivatives of 'transformation' combined with 'care', 'nursing', 'patient safety', 'Transforming Care at the Bedside', 'the Productive Ward' and 'Studer Group'. A comparison of the three approaches revealed similarities including: the foci of the approaches; interventions employed; and the outcomes measured. Key differences identified are the implementation models used, spread strategies and sustainability of the approaches. The approaches appear to be complementary and a hybrid of the approaches such as a blend of a top-down and bottom-up leadership strategy may offer more sustainable behavioural change. These approaches transform the way nurses do their work, how they work with others and how they view the care they provide to promote patient safety. All the approaches involve the implementation of multiple interventions occurring simultaneously to affect improvements in patient safety. The approaches are complementary and a hybrid approach may offer more sustainable outcomes. © 2011 Blackwell Publishing Ltd.

Assessing the accuracy of MISR and MISR-simulated cloud top heights using CloudSat- and CALIPSO-retrieved hydrometeor profiles

NASA Astrophysics Data System (ADS)

Hillman, Benjamin R.; Marchand, Roger T.; Ackerman, Thomas P.; Mace, Gerald G.; Benson, Sally

2017-03-01

Satellite retrievals of cloud properties are often used in the evaluation of global climate models, and in recent years satellite instrument simulators have been used to account for known retrieval biases in order to make more consistent comparisons between models and retrievals. Many of these simulators have seen little critical evaluation. Here we evaluate the Multiangle Imaging Spectroradiometer (MISR) simulator by using visible extinction profiles retrieved from a combination of CloudSat, CALIPSO, MODIS, and AMSR-E observations as inputs to the MISR simulator and comparing cloud top height statistics from the MISR simulator with those retrieved by MISR. Overall, we find that the occurrence of middle- and high-altitude topped clouds agrees well between MISR retrievals and the MISR-simulated output, with distributions of middle- and high-topped cloud cover typically agreeing to better than 5% in both zonal and regional averages. However, there are significant differences in the occurrence of low-topped clouds between MISR retrievals and MISR-simulated output that are due to differences in the detection of low-level clouds between MISR and the combined retrievals used to drive the MISR simulator, rather than due to errors in the MISR simulator cloud top height adjustment. This difference highlights the importance of sensor resolution and boundary layer cloud spatial structure in determining low-altitude cloud cover. The MISR-simulated and MISR-retrieved cloud optical depth also show systematic differences, which are also likely due in part to cloud spatial structure.

Top 10 Responses to the Commentaries on Dixon, Reed, Smith et al. (2015).

PubMed

Dixon, Mark R; Reed, Derek D; Smith, Tristram; Belisle, Jordan; Jackson, Rachel E

2015-10-01

In a previous article (Dixon et al. Behavior Analysis in Practice, 8 (1), 7-15, 2015), we put forward data suggesting that most behavior analytic faculty do not publish in major behavior analytic journals, and in only about 50 % of behavior analysis programs have faculty combined to produce ten or more empirical articles. Several commentaries followed the release of our article, with content that ranged from supporting our endeavors and confirming the dangerous position our field may be in to highlighting the need for further refinement in procedures used to rank the quality of behavior analysis graduate training programs. Presented in the present article are our "top 10" responses to these commentaries.

Public Health Information Systems: Priorities and Practices for Successful Deployments.

PubMed

Pearce, Martin

2016-01-01

A fast paced workshop designed for senior public health decision makers and clinical leaders implementing information systems to support delivery of public health programs. The tutorial will introduce public health information systems and provide best practices for implementing solutions related to immunization, communicable disease case management and outbreak management. Using a combination of formats, the tutorial will: • Highlight key functionality of public health information systems. • Review global crises currently exposing gaps and deficiencies in public health information. • Examine governance, planning, and implementation priorities. • Highlight considerations supporting implementations nationally and in special populations. • Provide real, actionable lessons learned to take away and apply in the real world.

Integrated Online Software for Libraries: An Overview of Today's Best-Selling IOLS. Options from the U.S. Perspective.

ERIC Educational Resources Information Center

Cibbarelli, Pamela

1996-01-01

Profiles the top-selling IOLS (integrated online library systems) software for libraries based on sales figures reported in the 1996 "Library Journal" annual survey of the library automation marketplace. Highlights include microcomputer-based systems and minicomputer-based systems, system components, MARC formats, and market sectors.…

2016 State of the State Addresses: Governors' Top Education Issues. Education Trends

ERIC Educational Resources Information Center

Auck, Alyssa; Railey, Hunter

2016-01-01

Each year, governors take the stage to highlight accomplishments and outline policy priorities for their states. In an effort to provide up-to-date information on education policy trends, Education Commission of the States tracks all education policy proposals and accomplishments featured by governors in these State of the State addresses. At the…

""Delicious" Politics"--The Use of Social Bookmarking in Politics Teaching

ERIC Educational Resources Information Center

Lightfoot, Simon

2012-01-01

This case study highlights the use of the social bookmarking site "Delicious" on a Level 2 module "Governing the EU." The nature of politics as a discipline is that it is constantly evolving such that new developments and policies emerge almost every day. It is therefore imperative that the students keep on top of these…

Illinois' Early Childhood Innovation Zones: A New Model for State Policy? IERC 2017-1. Research Highlights

ERIC Educational Resources Information Center

White, Bradford R.; Colaninno, Carol E.; Doll, Mimi; Lewandowski, Holly

2017-01-01

The Early Childhood Innovation Zones initiative was established by Illinois Action for Children (IAFC), with guidance from the Illinois Governor's Office for Early Childhood Development. Funded by a Race to the Top--Early Learning Challenge grant, this initiative supported capacity building efforts for organizations working with young children in…

A Graphical Journey of Innovative Organic Architectures that Have Improved Our Lives

ERIC Educational Resources Information Center

McGrath, Nicholas A.; Brichacek, Matthew; Njardarson, Jon T.

2010-01-01

A new free graphical teaching tool that highlights the beautiful organic architectures of the top selling pharmaceuticals is detailed on two posters. In addition to the multitude of teaching and data-mining opportunities these posters offer, they were also created to emphasize the central role organic chemists play in the development of new…

Degrees Conferred by Connecticut Institutions of Higher Education Highlights, 2007-08. Report

ERIC Educational Resources Information Center

Connecticut Department of Higher Education (NJ1), 2009

2009-01-01

This paper presents the degrees conferred by Connecticut institutions of higher education in 2007-08. Connecticut colleges and universities awarded 36,634 degrees in 2007-08 (up 1.6% over 2006-07), the state's seventh consecutive year of growth and a 28 percent increase since 1998. Once again, the top five degree-producing disciplines were…

Perceptions of Australia as a Postgraduate Research Destination. Go8 Backgrounder 11

ERIC Educational Resources Information Center

Group of Eight (NJ1), 2010

2010-01-01

In 2009 the Group of Eight (Go8) commissioned market research to examine the attitudes, perceptions and experiences of Australia as a destination for study at the Higher Research Degree level. This backgrounder highlights some of the positive aspects of the Australian experience. The top five aggregated strengths of Australia as a research…

Marketing and Student Recruitment Practices for Master's-Level Graduate Programs, 2012. Trends in Enrollment Management

ERIC Educational Resources Information Center

Noel-Levitz, Inc, 2012

2012-01-01

What's working in the area of marketing and recruiting for master's-level graduate programs? To find out, the National Association of Graduate Admissions Professionals (NAGAP) and Noel-Levitz conducted a national, Web-based poll to determine and report the most effective practices. Highlights from the findings: (1) Among the "top 10" most…

A Web-based, secure, light weight clinical multimedia data capture and display system.

PubMed Central

Wang, S. S.; Starren, J.

2000-01-01

Computer-based patient records are traditionally composed of textual data. Integration of multimedia data has been historically slow. Multimedia data such as image, audio, and video have been traditionally more difficult to handle. An implementation of a clinical system for multimedia data is discussed. The system implementation uses Java, Secure Socket Layer (SSL), and Oracle 8i. The system is on top of the Internet so it is architectural independent, cross-platform, cross-vendor, and secure. Design and implementations issues are discussed. Images Figure 2 Figure 3 PMID:11080014

Re-membering the body: applications of computational neuroscience to the top-down control of regeneration of limbs and other complex organs.

PubMed

Pezzulo, G; Levin, M

2015-12-01

A major goal of regenerative medicine and bioengineering is the regeneration of complex organs, such as limbs, and the capability to create artificial constructs (so-called biobots) with defined morphologies and robust self-repair capabilities. Developmental biology presents remarkable examples of systems that self-assemble and regenerate complex structures toward their correct shape despite significant perturbations. A fundamental challenge is to translate progress in molecular genetics into control of large-scale organismal anatomy, and the field is still searching for an appropriate theoretical paradigm for facilitating control of pattern homeostasis. However, computational neuroscience provides many examples in which cell networks - brains - store memories (e.g., of geometric configurations, rules, and patterns) and coordinate their activity towards proximal and distant goals. In this Perspective, we propose that programming large-scale morphogenesis requires exploiting the information processing by which cellular structures work toward specific shapes. In non-neural cells, as in the brain, bioelectric signaling implements information processing, decision-making, and memory in regulating pattern and its remodeling. Thus, approaches used in computational neuroscience to understand goal-seeking neural systems offer a toolbox of techniques to model and control regenerative pattern formation. Here, we review recent data on developmental bioelectricity as a regulator of patterning, and propose that target morphology could be encoded within tissues as a kind of memory, using the same molecular mechanisms and algorithms so successfully exploited by the brain. We highlight the next steps of an unconventional research program, which may allow top-down control of growth and form for numerous applications in regenerative medicine and synthetic bioengineering.

Convergence and Divergence in a Multi-Model Ensemble of Terrestrial Ecosystem Models in North America

NASA Astrophysics Data System (ADS)

Dungan, J. L.; Wang, W.; Hashimoto, H.; Michaelis, A.; Milesi, C.; Ichii, K.; Nemani, R. R.

2009-12-01

In support of NACP, we are conducting an ensemble modeling exercise using the Terrestrial Observation and Prediction System (TOPS) to evaluate uncertainties among ecosystem models, satellite datasets, and in-situ measurements. The models used in the experiment include public-domain versions of Biome-BGC, LPJ, TOPS-BGC, and CASA, driven by a consistent set of climate fields for North America at 8km resolution and daily/monthly time steps over the period of 1982-2006. The reference datasets include MODIS Gross Primary Production (GPP) and Net Primary Production (NPP) products, Fluxnet measurements, and other observational data. The simulation results and the reference datasets are consistently processed and systematically compared in the climate (temperature-precipitation) space; in particular, an alternative to the Taylor diagram is developed to facilitate model-data intercomparisons in multi-dimensional space. The key findings of this study indicate that: the simulated GPP/NPP fluxes are in general agreement with observations over forests, but are biased low (underestimated) over non-forest types; large uncertainties of biomass and soil carbon stocks are found among the models (and reference datasets), often induced by seemingly “small” differences in model parameters and implementation details; the simulated Net Ecosystem Production (NEP) mainly responds to non-respiratory disturbances (e.g. fire) in the models and therefore is difficult to compare with flux data; and the seasonality and interannual variability of NEP varies significantly among models and reference datasets. These findings highlight the problem inherent in relying on only one modeling approach to map surface carbon fluxes and emphasize the pressing necessity of expanded and enhanced monitoring systems to narrow critical structural and parametrical uncertainties among ecosystem models.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gao, Jingjing, E-mail: Jingjing@plan.aau.dk; Christensen, Per; Kørnøv, Lone

In the last decades, China has introduced a set of indicators to guide the Strategic Environmental Assessment (SEA) practice. The most recent indicator system proposed in 2009 is based on sector-specific guidelines and it found its justification in past negative experiences with more general guidelines (from 2003), which were mostly inspired by, or copied from, international experiences. Based on interviews with practitioners, researchers and administrators, we map and analyse the change in the national guidelines. This analysis is based on a description of the indicators that makes it possible to discern different aggregation levels of indicators and then trace themore » changes occurring under two sets of guidelines. The analysis also reveals the reasons and rationales behind the changes found in the guidelines. This analysis is inspired by implementation theory and a description of some of the more general trends in the development of SEA and other environmental policies in a recent Chinese context. Beside a more top-down, intentional approach specifying indicators for different sectors based on Chinese experiences from the preceding years, another significant change, following the new guidelines, is a more bottom-up approach which gives more discretion to practitioners. This entails a call for practitioners to make decisions on indicators, which involves an interpretation of the ones present in sector guidance. Highlights: • Focusing on the new Chinese national SEA guidelines proposed in 2009 • Mapping and analysing the most recent change in the indicator system • Revealing the reasons and rationales behind the changes found in the new guidelines • A top-down intention specifying indicators for different sectors • A bottom-up effect in giving discretion and interpretation of using indicators.« less

Silicon graphene Bragg gratings.

PubMed

Capmany, José; Domenech, David; Muñoz, Pascual

2014-03-10

We propose the use of interleaved graphene sections on top of a silicon waveguide to implement tunable Bragg gratings. The filter central wavelength and bandwidth can be controlled changing the chemical potential of the graphene sections. Apodization techniques are also presented.

78 FR 77109 - Agency Information Collection Activities; Comment Request; Race to the Top-District Annual...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-20

... implementing personalized learning environments, including narrative sections on progress and key performance... electronically through the Federal eRulemaking Portal at http://www.regulations.gov by selecting Docket ID number...

Business Ethics and Your Organisation.

ERIC Educational Resources Information Center

Drummond, John

1990-01-01

Good ethics are good business. Top management should be committed to a code of ethics based on a true participative process. The organization should be willing to commit resources for training to ensure proper implementation of the code. (SK)

Process for 3D chip stacking

DOEpatents

Malba, V.

1998-11-10

A manufacturable process for fabricating electrical interconnects which extend from a top surface of an integrated circuit chip to a sidewall of the chip using laser pantography to pattern three dimensional interconnects. The electrical interconnects may be of an L-connect or L-shaped type. The process implements three dimensional (3D) stacking by moving the conventional bond or interface pads on a chip to the sidewall of the chip. Implementation of the process includes: (1) holding individual chips for batch processing, (2) depositing a dielectric passivation layer on the top and sidewalls of the chips, (3) opening vias in the dielectric, (4) forming the interconnects by laser pantography, and (5) removing the chips from the holding means. The process enables low cost manufacturing of chips with bond pads on the sidewalls, which enables stacking for increased performance, reduced space, and higher functional per unit volume. 3 figs.

Process for 3D chip stacking

DOEpatents

Malba, Vincent

1998-01-01

A manufacturable process for fabricating electrical interconnects which extend from a top surface of an integrated circuit chip to a sidewall of the chip using laser pantography to pattern three dimensional interconnects. The electrical interconnects may be of an L-connect or L-shaped type. The process implements three dimensional (3D) stacking by moving the conventional bond or interface pads on a chip to the sidewall of the chip. Implementation of the process includes: 1) holding individual chips for batch processing, 2) depositing a dielectric passivation layer on the top and sidewalls of the chips, 3) opening vias in the dielectric, 4) forming the interconnects by laser pantography, and 5) removing the chips from the holding means. The process enables low cost manufacturing of chips with bond pads on the sidewalls, which enables stacking for increased performance, reduced space, and higher functional per unit volume.

Race to the Top: Education Could Better Support Grantees and Help Them Address Capacity Challenges. Report to the Ranking Member, Subcommittee on Labor, Health and Human Services, Education and Related Agencies, Committee on Appropriations, House of Representatives. GAO-15-295

ERIC Educational Resources Information Center

Nowicki, Jacqueline M.

2015-01-01

The Department of Education (Education) created Race To the Top (RTT) under the American Recovery and Reinvestment Act of 2009. From 2010 through 2011, Education awarded $4 billion in competitive grant funds to 19 states to reform core areas of K-12 education. RTT states also committed to building capacity to implement and sustain reforms. GAO and…

Scalable and reusable emulator for evaluating the performance of SS7 networks

NASA Astrophysics Data System (ADS)

Lazar, Aurel A.; Tseng, Kent H.; Lim, Koon Seng; Choe, Winston

1994-04-01

A scalable and reusable emulator was designed and implemented for studying the behavior of SS7 networks. The emulator design was largely based on public domain software. It was developed on top of an environment supported by PVM, the Parallel Virtual Machine, and managed by OSIMIS-the OSI Management Information Service platform. The emulator runs on top of a commercially available ATM LAN interconnecting engineering workstations. As a case study for evaluating the emulator, the behavior of the Singapore National SS7 Network under fault and unbalanced loading conditions was investigated.

Top 50 most cited articles on primary tumors of the spine.

PubMed

Alan, Nima; Cohen, Jonathan; Ozpinar, Alp; Agarwal, Nitin; Kanter, Adam S; Okonkwo, David O; Hamilton, D Kojo

2017-08-01

Citation analysis was performed in order to identify the top 50 most cited articles pertaining to the field of primary spinal tumors. This collection of articles highlights important trends in the neurosurgical literature. We searched the Thomson Reuters Web of Knowledge in order to identify articles pertaining to primary tumors of the spine. Impertinent articles were removed. The top 50 most cited articles were identified. Thereafter, article characteristics were determined including article type, article topic, level of evidence, and citation rate. The selected articles were published between 1951 and 2008. The most productive year was 1997 with 6 publications. The top 50 articles were published in twenty-two different journals, most commonly in Neurosurgery (12), Journal of Neurosurgery (8), and Spine (6). The most frequently cited article was by Tomita et al. written in 1997 which described total en bloc spondylectomy as a novel surgical technique in management of primary tumors of the vertebral column. We identified the 50 most-cited articles in the field of primary spinal tumors. This collection of articles serves as a reference for recognizing impactful studies in the field. Copyright © 2017. Published by Elsevier Ltd.

Incorporating anthropogenic effects into trophic ecology: predator-prey interactions in a human-dominated landscape.

PubMed

Dorresteijn, Ine; Schultner, Jannik; Nimmo, Dale G; Fischer, Joern; Hanspach, Jan; Kuemmerle, Tobias; Kehoe, Laura; Ritchie, Euan G

2015-09-07

Apex predators perform important functions that regulate ecosystems worldwide. However, little is known about how ecosystem regulation by predators is influenced by human activities. In particular, how important are top-down effects of predators relative to direct and indirect human-mediated bottom-up and top-down processes? Combining data on species' occurrence from camera traps and hunting records, we aimed to quantify the relative effects of top-down and bottom-up processes in shaping predator and prey distributions in a human-dominated landscape in Transylvania, Romania. By global standards this system is diverse, including apex predators (brown bear and wolf), mesopredators (red fox) and large herbivores (roe and red deer). Humans and free-ranging dogs represent additional predators in the system. Using structural equation modelling, we found that apex predators suppress lower trophic levels, especially herbivores. However, direct and indirect top-down effects of humans affected the ecosystem more strongly, influencing species at all trophic levels. Our study highlights the need to explicitly embed humans and their influences within trophic cascade theory. This will greatly expand our understanding of species interactions in human-modified landscapes, which compose the majority of the Earth's terrestrial surface. © 2015 The Author(s).

Top-down Mass Spectrometry of Cardiac Myofilament Proteins in Health and Disease

PubMed Central

Ying, Peng; Serife, Ayaz-Guner; Deyang, Yu; Ying, Ge

2014-01-01

Myofilaments are composed of thin and thick filaments which coordinate with each other to regulate muscle contraction and relaxation. Posttranslational modifications (PTMs) together with genetic variations and alternative splicing of the myofilament proteins play essential roles in regulating cardiac contractility in health and disease. Therefore, a comprehensive characterization of the myofilament proteins in physiological and pathological conditions is essential for better understanding the molecular basis of cardiac function and dysfunction. Due to the vast complexity and dynamic nature of proteins, it is challenging to obtain a holistic view of myofilament protein modifications. In recent years, top-down mass spectrometry (MS) has emerged as a powerful approach to study isoform composition and PTMs of proteins owing to its advantage of complete sequence coverage and its ability to identify PTMs and sequence variants without a priori knowledge. In this review, we will discuss the application of top-down MS to study cardiac myofilaments and highlight the insights it provides into the understanding of molecular mechanisms in contractile dysfunction of heart failure. Particularly, recent results of cardiac troponin and tropomyosin modifications will be elaborated. The limitations and perspectives on the use of top-down MS for myofilament protein characterization will also be briefly discussed. PMID:24945106

Top-down proteomics for the analysis of proteolytic events - Methods, applications and perspectives.

PubMed

Tholey, Andreas; Becker, Alexander

2017-11-01

Mass spectrometry based proteomics is an indispensable tool for almost all research areas relevant for the understanding of proteolytic processing, ranging from the identification of substrates, products and cleavage sites up to the analysis of structural features influencing protease activity. The majority of methods for these studies are based on bottom-up proteomics performing analysis at peptide level. As this approach is characterized by a number of pitfalls, e.g. loss of molecular information, there is an ongoing effort to establish top-down proteomics, performing separation and MS analysis both at intact protein level. We briefly introduce major approaches of bottom-up proteomics used in the field of protease research and highlight the shortcomings of these methods. We then discuss the present state-of-the-art of top-down proteomics. Together with the discussion of known challenges we show the potential of this approach and present a number of successful applications of top-down proteomics in protease research. This article is part of a Special Issue entitled: Proteolysis as a Regulatory Event in Pathophysiology edited by Stefan Rose-John. Copyright © 2017 Elsevier B.V. All rights reserved.

Incorporating anthropogenic effects into trophic ecology: predator–prey interactions in a human-dominated landscape

PubMed Central

Dorresteijn, Ine; Schultner, Jannik; Nimmo, Dale G.; Fischer, Joern; Hanspach, Jan; Kuemmerle, Tobias; Kehoe, Laura; Ritchie, Euan G.

2015-01-01

Apex predators perform important functions that regulate ecosystems worldwide. However, little is known about how ecosystem regulation by predators is influenced by human activities. In particular, how important are top-down effects of predators relative to direct and indirect human-mediated bottom-up and top-down processes? Combining data on species' occurrence from camera traps and hunting records, we aimed to quantify the relative effects of top-down and bottom-up processes in shaping predator and prey distributions in a human-dominated landscape in Transylvania, Romania. By global standards this system is diverse, including apex predators (brown bear and wolf), mesopredators (red fox) and large herbivores (roe and red deer). Humans and free-ranging dogs represent additional predators in the system. Using structural equation modelling, we found that apex predators suppress lower trophic levels, especially herbivores. However, direct and indirect top-down effects of humans affected the ecosystem more strongly, influencing species at all trophic levels. Our study highlights the need to explicitly embed humans and their influences within trophic cascade theory. This will greatly expand our understanding of species interactions in human-modified landscapes, which compose the majority of the Earth's terrestrial surface. PMID:26336169

On Variable Geometric Factor Systems for Top-Hat Electrostatic Space Plasma Analyzers

NASA Technical Reports Server (NTRS)

Kataria, Dhiren O.; Collinson, Glyn A.

2010-01-01

Even in the relatively small region of space that is the Earth's magnetosphere, ion and electron fluxes can vary by several orders of magnitude. Top-hat electrostatic analyzers currently do not possess the dynamic range required to sample plasma under all conditions. The purpose of this study was to compare, through computer simulation, three new electrostatic methods that would allow the sensitivity of a sensor to be varied through control of its geometric factor (GF) (much like an aperture on a camera). The methods studied were inner filter plates, split hemispherical analyzer (SHA) and top-cap electrode. This is the first discussion of the filter plate concept and also the first study where all three systems are studied within a common analyzer design, so that their relative merits could be fairly compared. Filter plates were found to have the important advantage that they facilitate the reduction in instrument sensitivity whilst keeping all other instrument parameters constant. However, it was discovered that filter plates have numerous disadvantages that make such a system impracticable for a top-hat electrostatic analyzer. It was found that both the top-cap electrode and SHA are promising variable geometric factor system (VGFS) concepts for implementation into a top-hat electrostatic analyzer, each with distinct advantages over the other.

Effects of dose and duration of Robot-Assisted Gait Training on walking ability of children affected by cerebral palsy.

PubMed

Peri, Elisabetta; Turconi, Anna Carla; Biffi, Emilia; Maghini, Cristina; Panzeri, Daniele; Morganti, Roberta; Pedrocchi, Alessandra; Gagliardi, Chiara

2017-08-09

Robot-Assisted Gait Training (RAGT) is a widespread approach for locomotion rehabilitation but information about intervention frequency and duration is still lacking. To evaluate the effect of frequency and duration of a RAGT on motor outcome of children affected by Cerebral Palsy (CP). Forty-four CP children (age 4-17) underwent one among four different intensive trainings with equal dose of intervention, combining Task-Oriented Physiotherapy (TOP) and RAGT: 40 sessions (4 sessions/week) over 10 weeks of sole TOP (group1) or RAGT (group2) or RAGT and TOP (2 + 2 sessions/week; group3); 40 sessions in shorter period (4 weeks) of RAGT and TOP (5 + 5 sessions/week; group4). Each child was assessed before, after the training and after 3 months with: Ashworth, gross motor function measure (GMFM)-88, GMFM-66, six minutes walking test and gait analysis. No differences among the 4 protocols were highlighted although both groups with exclusive physiotherapy and RAGT obtained significant improvements in GMFM-88, GMFM-E and GMFM-66 while the mixed approaches did not show significant changes. Single-treatment approaches seem to be more effective than mixed approaches, independently from the duration (4 or 10 weeks). RAGT seems to have similar effect with respect to the traditional TOP, at least over 10 weeks.

Clustering performances in the NBA according to players' anthropometric attributes and playing experience.

PubMed

Zhang, Shaoliang; Lorenzo, Alberto; Gómez, Miguel-Angel; Mateus, Nuno; Gonçalves, Bruno; Sampaio, Jaime

2018-04-20

The aim of this study was: (i) to group basketball players into similar clusters based on a combination of anthropometric characteristics and playing experience; and (ii) explore the distribution of players (included starters and non-starters) from different levels of teams within the obtained clusters. The game-related statistics from 699 regular season balanced games were analyzed using a two-step cluster model and a discriminant analysis. The clustering process allowed identifying five different player profiles: Top height and weight (HW) with low experience, TopHW-LowE; Middle HW with middle experience, MiddleHW-MiddleE; Middle HW with top experience, MiddleHW-TopE; Low HW with low experience, LowHW-LowE; Low HW with middle experience, LowHW-MiddleE. Discriminant analysis showed that TopHW-LowE group was highlighted by two-point field goals made and missed, offensive and defensive rebounds, blocks, and personal fouls; whereas the LowHW-LowE group made fewest passes and touches. The players from weaker teams were mostly distributed in LowHW-LowE group, whereas players from stronger teams were mainly grouped in LowHW-MiddleE group; and players that participated in the finals were allocated in the MiddleHW-MiddleE group. These results provide alternative references for basketball staff concerning the process of evaluating performance.

NLO Higgs+jet at Large Transverse Momenta Including Top Quark Mass Effects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Neumann, Tobias

We present a next-to-leading order calculation of H+jet in gluon fusion including the effect of a finite top quark massmore » $$m_t$$ at large transverse momenta. Using the recently published two-loop amplitudes in the high energy expansion and our previous setup that includes finite $$m_t$$ effects in a low energy expansion, we are able to obtain $$m_t$$-finite results for transverse momenta below 225 GeV and above 500 GeV with negligible remaining top quark mass uncertainty. The only remaining region that has to rely on the common leading order rescaling approach is the threshold region $$\\sqrt{\\hat s}\\simeq 2m_t$$. We demonstrate that this rescaling provides an excellent approximation in the high $$p_T$$ region. Our calculation settles the issue of top quark mass effects at large transverse momenta. It is implemented in the parton level Monte Carlo code MCFM and is publicly available immediately in version 8.2.« less

Measurement of normalized differential t\\overline{t} cross sections in the dilepton channel from pp collisions at √{s}=13 TeV

NASA Astrophysics Data System (ADS)

Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Ambrogi, F.; Asilar, E.; Bergauer, T.; Brandstetter, J.; Brondolin, E.; Dragicevic, M.; Erö, J.; Flechl, M.; Friedl, M.; Frühwirth, R.; Ghete, V. M.; Grossmann, J.; Hrubec, J.; Jeitler, M.; König, A.; Krammer, N.; Krätschmer, I.; Liko, D.; Madlener, T.; Mikulec, I.; Pree, E.; Rabady, D.; Rad, N.; Rohringer, H.; Schieck, J.; Schöfbeck, R.; Spanring, M.; Spitzbart, D.; Strauss, J.; Waltenberger, W.; Wittmann, J.; Wulz, C.-E.; Zarucki, M.; Chekhovsky, V.; Mossolov, V.; Suarez Gonzalez, J.; De Wolf, E. A.; Janssen, X.; Lauwers, J.; Van De Klundert, M.; Van Haevermaet, H.; Van Mechelen, P.; Van Remortel, N.; Van Spilbeeck, A.; Abu Zeid, S.; Blekman, F.; D'Hondt, J.; De Bruyn, I.; De Clercq, J.; Deroover, K.; Flouris, G.; Lowette, S.; Moortgat, S.; Moreels, L.; Olbrechts, A.; Python, Q.; Skovpen, K.; Tavernier, S.; Van Doninck, W.; Van Mulders, P.; Van Parijs, I.; Brun, H.; Clerbaux, B.; De Lentdecker, G.; Delannoy, H.; Fasanella, G.; Favart, L.; Goldouzian, R.; Grebenyuk, A.; Karapostoli, G.; Lenzi, T.; Luetic, J.; Maerschalk, T.; Marinov, A.; Randle-conde, A.; Seva, T.; Vander Velde, C.; Vanlaer, P.; Vannerom, D.; Yonamine, R.; Zenoni, F.; Zhang, F.; Cimmino, A.; Cornelis, T.; Dobur, D.; Fagot, A.; Gul, M.; Khvastunov, I.; Poyraz, D.; Roskas, C.; Salva, S.; Tytgat, M.; Verbeke, W.; Zaganidis, N.; Bakhshiansohi, H.; Bondu, O.; Brochet, S.; Bruno, G.; Caudron, A.; De Visscher, S.; Delaere, C.; Delcourt, M.; Francois, B.; Giammanco, A.; Jafari, A.; Komm, M.; Krintiras, G.; Lemaitre, V.; Magitteri, A.; Mertens, A.; Musich, M.; Piotrzkowski, K.; Quertenmont, L.; Vidal Marono, M.; Wertz, S.; Beliy, N.; Aldá Júnior, W. L.; Alves, F. L.; Alves, G. A.; Brito, L.; Correa Martins Junior, M.; Hensel, C.; Moraes, A.; Pol, M. E.; Rebello Teles, P.; Belchior Batista Das Chagas, E.; Carvalho, W.; Chinellato, J.; Custódio, A.; Da Costa, E. M.; Da Silveira, G. G.; De Jesus Damiao, D.; Fonseca De Souza, S.; Huertas Guativa, L. M.; Malbouisson, H.; Melo De Almeida, M.; Mora Herrera, C.; Mundim, L.; Nogima, H.; Santoro, A.; Sznajder, A.; Tonelli Manganote, E. J.; Torres Da Silva De Araujo, F.; Vilela Pereira, A.; Ahuja, S.; Bernardes, C. A.; Fernandez Perez Tomei, T. R.; Gregores, E. M.; Mercadante, P. G.; Moon, C. S.; Novaes, S. F.; Padula, Sandra S.; Romero Abad, D.; Ruiz Vargas, J. C.; Aleksandrov, A.; Hadjiiska, R.; Iaydjiev, P.; Misheva, M.; Rodozov, M.; Stoykova, S.; Sultanov, G.; Vutova, M.; Dimitrov, A.; Glushkov, I.; Litov, L.; Pavlov, B.; Petkov, P.; Fang, W.; Gao, X.; Ahmad, M.; Bian, J. G.; Chen, G. M.; Chen, H. S.; Chen, M.; Chen, Y.; Jiang, C. H.; Leggat, D.; Liu, Z.; Romeo, F.; Shaheen, S. M.; Spiezia, A.; Tao, J.; Wang, C.; Wang, Z.; Yazgan, E.; Zhang, H.; Zhao, J.; Ban, Y.; Chen, G.; Li, Q.; Liu, S.; Mao, Y.; Qian, S. J.; Wang, D.; Xu, Z.; Avila, C.; Cabrera, A.; Chaparro Sierra, L. F.; Florez, C.; González Hernández, C. F.; Ruiz Alvarez, J. D.; Courbon, B.; Godinovic, N.; Lelas, D.; Puljak, I.; Ribeiro Cipriano, P. M.; Sculac, T.; Antunovic, Z.; Kovac, M.; Brigljevic, V.; Ferencek, D.; Kadija, K.; Mesic, B.; Susa, T.; Ather, M. W.; Attikis, A.; Mavromanolakis, G.; Mousa, J.; Nicolaou, C.; Ptochos, F.; Razis, P. A.; Rykaczewski, H.; Finger, M.; Finger, M.; Carrera Jarrin, E.; Abdelalim, A. A.; Mohammed, Y.; Salama, E.; Dewanjee, R. K.; Kadastik, M.; Perrini, L.; Raidal, M.; Tiko, A.; Veelken, C.; Eerola, P.; Pekkanen, J.; Voutilainen, M.; Härkönen, J.; Järvinen, T.; Karimäki, V.; Kinnunen, R.; Lampén, T.; Lassila-Perini, K.; Lehti, S.; Lindén, T.; Luukka, P.; Tuominen, E.; Tuominiemi, J.; Tuovinen, E.; Talvitie, J.; Tuuva, T.; Besancon, M.; Couderc, F.; Dejardin, M.; Denegri, D.; Faure, J. L.; Ferri, F.; Ganjour, S.; Ghosh, S.; Givernaud, A.; Gras, P.; Hamel de Monchenault, G.; Jarry, P.; Kucher, I.; Locci, E.; Machet, M.; Malcles, J.; Negro, G.; Rander, J.; Rosowsky, A.; Sahin, M. Ö.; Titov, M.; Abdulsalam, A.; Antropov, I.; Baffioni, S.; Beaudette, F.; Busson, P.; Cadamuro, L.; Charlot, C.; Davignon, O.; Granier de Cassagnac, R.; Jo, M.; Lisniak, S.; Lobanov, A.; Martin Blanco, J.; Nguyen, M.; Ochando, C.; Ortona, G.; Paganini, P.; Pigard, P.; Regnard, S.; Salerno, R.; Sauvan, J. B.; Sirois, Y.; Stahl Leiton, A. G.; Strebler, T.; Yilmaz, Y.; Zabi, A.; Zghiche, A.; Agram, J.-L.; Andrea, J.; Bloch, D.; Brom, J.-M.; Buttignol, M.; Chabert, E. C.; Chanon, N.; Collard, C.; Conte, E.; Coubez, X.; Fontaine, J.-C.; Gelé, D.; Goerlach, U.; Jansová, M.; Le Bihan, A.-C.; Van Hove, P.; Gadrat, S.; Beauceron, S.; Bernet, C.; Boudoul, G.; Chierici, R.; Contardo, D.; Depasse, P.; El Mamouni, H.; Fay, J.; Finco, L.; Gascon, S.; Gouzevitch, M.; Grenier, G.; Ille, B.; Lagarde, F.; Laktineh, I. B.; Lethuillier, M.; Mirabito, L.; Pequegnot, A. L.; Perries, S.; Popov, A.; Sordini, V.; Vander Donckt, M.; Viret, S.; Khvedelidze, A.; Tsamalaidze, Z.; Autermann, C.; Beranek, S.; Feld, L.; Kiesel, M. K.; Klein, K.; Lipinski, M.; Preuten, M.; Schomakers, C.; Schulz, J.; Verlage, T.; Albert, A.; Brodski, M.; Dietz-Laursonn, E.; Duchardt, D.; Endres, M.; Erdmann, M.; Erdweg, S.; Esch, T.; Fischer, R.; Güth, A.; Hamer, M.; Hebbeker, T.; Heidemann, C.; Hoepfner, K.; Knutzen, S.; Merschmeyer, M.; Meyer, A.; Millet, P.; Mukherjee, S.; Olschewski, M.; Padeken, K.; Pook, T.; Radziej, M.; Reithler, H.; Rieger, M.; Scheuch, F.; Teyssier, D.; Thüer, S.; Flügge, G.; Kargoll, B.; Kress, T.; Künsken, A.; Lingemann, J.; Müller, T.; Nehrkorn, A.; Nowack, A.; Pistone, C.; Pooth, O.; Stahl, A.; Aldaya Martin, M.; Arndt, T.; Asawatangtrakuldee, C.; Beernaert, K.; Behnke, O.; Behrens, U.; Bin Anuar, A. A.; Borras, K.; Botta, V.; Campbell, A.; Connor, P.; Contreras-Campana, C.; Costanza, F.; Diez Pardos, C.; Eckerlin, G.; Eckstein, D.; Eichhorn, T.; Eren, E.; Gallo, E.; Garay Garcia, J.; Geiser, A.; Gizhko, A.; Grados Luyando, J. M.; Grohsjean, A.; Gunnellini, P.; Harb, A.; Hauk, J.; Hempel, M.; Jung, H.; Kalogeropoulos, A.; Kasemann, M.; Keaveney, J.; Kleinwort, C.; Korol, I.; Krücker, D.; Lange, W.; Lelek, A.; Lenz, T.; Leonard, J.; Lipka, K.; Lohmann, W.; Mankel, R.; Melzer-Pellmann, I.-A.; Meyer, A. B.; Mittag, G.; Mnich, J.; Mussgiller, A.; Ntomari, E.; Pitzl, D.; Placakyte, R.; Raspereza, A.; Roland, B.; Savitskyi, M.; Saxena, P.; Shevchenko, R.; Spannagel, S.; Stefaniuk, N.; Van Onsem, G. P.; Walsh, R.; Wen, Y.; Wichmann, K.; Wissing, C.; Zenaiev, O.; Bein, S.; Blobel, V.; Centis Vignali, M.; Draeger, A. R.; Dreyer, T.; Garutti, E.; Gonzalez, D.; Haller, J.; Hoffmann, M.; Junkes, A.; Klanner, R.; Kogler, R.; Kovalchuk, N.; Kurz, S.; Lapsien, T.; Marchesini, I.; Marconi, D.; Meyer, M.; Niedziela, M.; Nowatschin, D.; Pantaleo, F.; Peiffer, T.; Perieanu, A.; Scharf, C.; Schleper, P.; Schmidt, A.; Schumann, S.; Schwandt, J.; Sonneveld, J.; Stadie, H.; Steinbrück, G.; Stober, F. M.; Stöver, M.; Tholen, H.; Troendle, D.; Usai, E.; Vanelderen, L.; Vanhoefer, A.; Vormwald, B.; Akbiyik, M.; Barth, C.; Baur, S.; Butz, E.; Caspart, R.; Chwalek, T.; Colombo, F.; De Boer, W.; Dierlamm, A.; Freund, B.; Friese, R.; Giffels, M.; Gilbert, A.; Haitz, D.; Hartmann, F.; Heindl, S. M.; Husemann, U.; Kassel, F.; Kudella, S.; Mildner, H.; Mozer, M. U.; Müller, Th.; Plagge, M.; Quast, G.; Rabbertz, K.; Schröder, M.; Shvetsov, I.; Sieber, G.; Simonis, H. J.; Ulrich, R.; Wayand, S.; Weber, M.; Weiler, T.; Williamson, S.; Wöhrmann, C.; Wolf, R.; Anagnostou, G.; Daskalakis, G.; Geralis, T.; Giakoumopoulou, V. A.; Kyriakis, A.; Loukas, D.; Topsis-Giotis, I.; Kesisoglou, S.; Panagiotou, A.; Saoulidou, N.; Evangelou, I.; Foudas, C.; Kokkas, P.; Manthos, N.; Papadopoulos, I.; Paradas, E.; Strologas, J.; Triantis, F. A.; Csanad, M.; Filipovic, N.; Pasztor, G.; Bencze, G.; Hajdu, C.; Horvath, D.; Sikler, F.; Veszpremi, V.; Vesztergombi, G.; Zsigmond, A. J.; Beni, N.; Czellar, S.; Karancsi, J.; Makovec, A.; Molnar, J.; Szillasi, Z.; Bartók, M.; Raics, P.; Trocsanyi, Z. L.; Ujvari, B.; Choudhury, S.; Komaragiri, J. R.; Bahinipati, S.; Bhowmik, S.; Mal, P.; Mandal, K.; Nayak, A.; Sahoo, D. K.; Sahoo, N.; Swain, S. K.; Bansal, S.; Beri, S. B.; Bhatnagar, V.; Bhawandeep, U.; Chawla, R.; Dhingra, N.; Kalsi, A. K.; Kaur, A.; Kaur, M.; Kumar, R.; Kumari, P.; Mehta, A.; Mittal, M.; Singh, J. B.; Walia, G.; Kumar, Ashok; Shah, Aashaq; Bhardwaj, A.; Chauhan, S.; Choudhary, B. C.; Garg, R. B.; Keshri, S.; Kumar, A.; Malhotra, S.; Naimuddin, M.; Ranjan, K.; Sharma, R.; Sharma, V.; Bhardwaj, R.; Bhattacharya, R.; Bhattacharya, S.; Dey, S.; Dutt, S.; Dutta, S.; Ghosh, S.; Majumdar, N.; Modak, A.; Mondal, K.; Mukhopadhyay, S.; Nandan, S.; Purohit, A.; Roy, A.; Roy, D.; Roy Chowdhury, S.; Sarkar, S.; Sharan, M.; Thakur, S.; Behera, P. K.; Chudasama, R.; Dutta, D.; Jha, V.; Kumar, V.; Mohanty, A. K.; Netrakanti, P. K.; Pant, L. M.; Shukla, P.; Topkar, A.; Aziz, T.; Dugad, S.; Mahakud, B.; Mitra, S.; Mohanty, G. B.; Parida, B.; Sur, N.; Sutar, B.; Banerjee, S.; Bhattacharya, S.; Chatterjee, S.; Das, P.; Guchait, M.; Jain, Sa.; Kumar, S.; Maity, M.; Majumder, G.; Mazumdar, K.; Sarkar, T.; Wickramage, N.; Chauhan, S.; Dube, S.; Hegde, V.; Kapoor, A.; Kothekar, K.; Pandey, S.; Rane, A.; Sharma, S.; Chenarani, S.; Eskandari Tadavani, E.; Etesami, S. M.; Khakzad, M.; Mohammadi Najafabadi, M.; Naseri, M.; Paktinat Mehdiabadi, S.; Rezaei Hosseinabadi, F.; Safarzadeh, B.; Zeinali, M.; Felcini, M.; Grunewald, M.; Abbrescia, M.; Calabria, C.; Caputo, C.; Colaleo, A.; Creanza, D.; Cristella, L.; De Filippis, N.; De Palma, M.; Errico, F.; Fiore, L.; Iaselli, G.; Maggi, G.; Maggi, M.; Miniello, G.; My, S.; Nuzzo, S.; Pompili, A.; Pugliese, G.; Radogna, R.; Ranieri, A.; Selvaggi, G.; Sharma, A.; Silvestris, L.; Venditti, R.; Verwilligen, P.; Abbiendi, G.; Battilana, C.; Bonacorsi, D.; Braibant-Giacomelli, S.; Brigliadori, L.; Campanini, R.; Capiluppi, P.; Castro, A.; Cavallo, F. R.; Chhibra, S. S.; Codispoti, G.; Cuffiani, M.; Dallavalle, G. M.; Fabbri, F.; Fanfani, A.; Fasanella, D.; Giacomelli, P.; Guiducci, L.; Marcellini, S.; Masetti, G.; Navarria, F. L.; Perrotta, A.; Rossi, A. M.; Rovelli, T.; Siroli, G. P.; Tosi, N.; Albergo, S.; Costa, S.; Di Mattia, A.; Giordano, F.; Potenza, R.; Tricomi, A.; Tuve, C.; Barbagli, G.; Chatterjee, K.; Ciulli, V.; Civinini, C.; D'Alessandro, R.; Focardi, E.; Lenzi, P.; Meschini, M.; Paoletti, S.; Russo, L.; Sguazzoni, G.; Strom, D.; Viliani, L.; Benussi, L.; Bianco, S.; Fabbri, F.; Piccolo, D.; Primavera, F.; Calvelli, V.; Ferro, F.; Robutti, E.; Tosi, S.; Brianza, L.; Brivio, F.; Ciriolo, V.; Dinardo, M. E.; Fiorendi, S.; Gennai, S.; Ghezzi, A.; Govoni, P.; Malberti, M.; Malvezzi, S.; Manzoni, R. A.; Menasce, D.; Moroni, L.; Paganoni, M.; Pauwels, K.; Pedrini, D.; Pigazzini, S.; Ragazzi, S.; Tabarelli de Fatis, T.; Buontempo, S.; Cavallo, N.; Di Guida, S.; Esposito, M.; Fabozzi, F.; Fienga, F.; Iorio, A. O. M.; Khan, W. 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T.; Ligabue, F.; Lomtadze, T.; Martini, L.; Messineo, A.; Palla, F.; Rizzi, A.; Savoy-Navarro, A.; Spagnolo, P.; Tenchini, R.; Tonelli, G.; Venturi, A.; Verdini, P. G.; Barone, L.; Cavallari, F.; Cipriani, M.; Daci, N.; Del Re, D.; Diemoz, M.; Gelli, S.; Longo, E.; Margaroli, F.; Marzocchi, B.; Meridiani, P.; Organtini, G.; Paramatti, R.; Preiato, F.; Rahatlou, S.; Rovelli, C.; Santanastasio, F.; Amapane, N.; Arcidiacono, R.; Argiro, S.; Arneodo, M.; Bartosik, N.; Bellan, R.; Biino, C.; Cartiglia, N.; Cenna, F.; Costa, M.; Covarelli, R.; Degano, A.; Demaria, N.; Kiani, B.; Mariotti, C.; Maselli, S.; Migliore, E.; Monaco, V.; Monteil, E.; Monteno, M.; Obertino, M. M.; Pacher, L.; Pastrone, N.; Pelliccioni, M.; Pinna Angioni, G. L.; Ravera, F.; Romero, A.; Ruspa, M.; Sacchi, R.; Shchelina, K.; Sola, V.; Solano, A.; Staiano, A.; Traczyk, P.; Belforte, S.; Casarsa, M.; Cossutti, F.; Della Ricca, G.; Zanetti, A.; Kim, D. H.; Kim, G. N.; Kim, M. S.; Lee, J.; Lee, S.; Lee, S. W.; Oh, Y. D.; Sekmen, S.; Son, D. C.; Yang, Y. C.; Lee, A.; Kim, H.; Moon, D. H.; Oh, G.; Brochero Cifuentes, J. A.; Goh, J.; Kim, T. J.; Cho, S.; Choi, S.; Go, Y.; Gyun, D.; Ha, S.; Hong, B.; Jo, Y.; Kim, Y.; Lee, K.; Lee, K. S.; Lee, S.; Lim, J.; Park, S. K.; Roh, Y.; Almond, J.; Kim, J.; Kim, J. S.; Lee, H.; Lee, K.; Nam, K.; Oh, S. B.; Radburn-Smith, B. C.; Seo, S. h.; Yang, U. K.; Yoo, H. D.; Yu, G. B.; Choi, M.; Kim, H.; Kim, J. H.; Lee, J. S. H.; Park, I. C.; Ryu, G.; Choi, Y.; Hwang, C.; Lee, J.; Yu, I.; Dudenas, V.; Juodagalvis, A.; Vaitkus, J.; Ahmed, I.; Ibrahim, Z. A.; Md Ali, M. A. B.; Mohamad Idris, F.; Wan Abdullah, W. A. T.; Yusli, M. N.; Zolkapli, Z.; Castilla-Valdez, H.; De La Cruz-Burelo, E.; Heredia-De La Cruz, I.; Lopez-Fernandez, R.; Mejia Guisao, J.; Sanchez-Hernandez, A.; Carrillo Moreno, S.; Oropeza Barrera, C.; Vazquez Valencia, F.; Pedraza, I.; Salazar Ibarguen, H. A.; Uribe Estrada, C.; Morelos Pineda, A.; Krofcheck, D.; Butler, P. H.; Ahmad, A.; Ahmad, M.; Hassan, Q.; Hoorani, H. R.; Saddique, A.; Shah, M. A.; Shoaib, M.; Waqas, M.; Bialkowska, H.; Bluj, M.; Boimska, B.; Frueboes, T.; Górski, M.; Kazana, M.; Nawrocki, K.; Romanowska-Rybinska, K.; Szleper, M.; Zalewski, P.; Bunkowski, K.; Byszuk, A.; Doroba, K.; Kalinowski, A.; Konecki, M.; Krolikowski, J.; Misiura, M.; Olszewski, M.; Pyskir, A.; Walczak, M.; Bargassa, P.; Beirão Da Cruz E Silva, C.; Calpas, B.; Di Francesco, A.; Faccioli, P.; Gallinaro, M.; Hollar, J.; Leonardo, N.; Lloret Iglesias, L.; Nemallapudi, M. 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A.; Mersi, S.; Meschi, E.; Milenovic, P.; Moortgat, F.; Mulders, M.; Neugebauer, H.; Orfanelli, S.; Orsini, L.; Pape, L.; Perez, E.; Peruzzi, M.; Petrilli, A.; Petrucciani, G.; Pfeiffer, A.; Pierini, M.; Racz, A.; Reis, T.; Rolandi, G.; Rovere, M.; Sakulin, H.; Schäfer, C.; Schwick, C.; Seidel, M.; Selvaggi, M.; Sharma, A.; Silva, P.; Sphicas, P.; Steggemann, J.; Stoye, M.; Tosi, M.; Treille, D.; Triossi, A.; Tsirou, A.; Veckalns, V.; Veres, G. I.; Verweij, M.; Wardle, N.; Zeuner, W. D.; Bertl, W.; Deiters, K.; Erdmann, W.; Horisberger, R.; Ingram, Q.; Kaestli, H. C.; Kotlinski, D.; Langenegger, U.; Rohe, T.; Wiederkehr, S. A.; Bachmair, F.; Bäni, L.; Berger, P.; Bianchini, L.; Casal, B.; Dissertori, G.; Dittmar, M.; Donegà, M.; Grab, C.; Heidegger, C.; Hits, D.; Hoss, J.; Kasieczka, G.; Klijnsma, T.; Lustermann, W.; Mangano, B.; Marionneau, M.; Meinhard, M. T.; Meister, D.; Micheli, F.; Musella, P.; Nessi-Tedaldi, F.; Pandolfi, F.; Pata, J.; Pauss, F.; Perrin, G.; Perrozzi, L.; Quittnat, M.; Rossini, M.; Schönenberger, M.; Shchutska, L.; Starodumov, A.; Tavolaro, V. R.; Theofilatos, K.; Vesterbacka Olsson, M. L.; Wallny, R.; Zagozdzinska, A.; Zhu, D. H.; Aarrestad, T. K.; Amsler, C.; Caminada, L.; Canelli, M. F.; De Cosa, A.; Donato, S.; Galloni, C.; Hinzmann, A.; Hreus, T.; Kilminster, B.; Ngadiuba, J.; Pinna, D.; Rauco, G.; Robmann, P.; Salerno, D.; Seitz, C.; Zucchetta, A.; Candelise, V.; Doan, T. H.; Jain, Sh.; Khurana, R.; Konyushikhin, M.; Kuo, C. M.; Lin, W.; Pozdnyakov, A.; Yu, S. S.; Kumar, Arun; Chang, P.; Chao, Y.; Chen, K. F.; Chen, P. H.; Fiori, F.; Hou, W.-S.; Hsiung, Y.; Liu, Y. F.; Lu, R.-S.; Miñano Moya, M.; Paganis, E.; Psallidas, A.; Tsai, J. f.; Asavapibhop, B.; Kovitanggoon, K.; Singh, G.; Srimanobhas, N.; Adiguzel, A.; Boran, F.; Cerci, S.; Damarseckin, S.; Demiroglu, Z. 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R.; Williams, T.; Baber, M.; Bainbridge, R.; Breeze, S.; Buchmuller, O.; Bundock, A.; Casasso, S.; Citron, M.; Colling, D.; Corpe, L.; Dauncey, P.; Davies, G.; De Wit, A.; Della Negra, M.; Di Maria, R.; Dunne, P.; Elwood, A.; Futyan, D.; Haddad, Y.; Hall, G.; Iles, G.; James, T.; Lane, R.; Laner, C.; Lyons, L.; Magnan, A.-M.; Malik, S.; Mastrolorenzo, L.; Matsushita, T.; Nash, J.; Nikitenko, A.; Pela, J.; Pesaresi, M.; Raymond, D. M.; Richards, A.; Rose, A.; Scott, E.; Seez, C.; Shtipliyski, A.; Summers, S.; Tapper, A.; Uchida, K.; Vazquez Acosta, M.; Virdee, T.; Winterbottom, D.; Wright, J.; Zenz, S. C.; Cole, J. E.; Hobson, P. R.; Khan, A.; Kyberd, P.; Reid, I. D.; Symonds, P.; Teodorescu, L.; Turner, M.; Borzou, A.; Call, K.; Dittmann, J.; Hatakeyama, K.; Liu, H.; Pastika, N.; Bartek, R.; Dominguez, A.; Buccilli, A.; Cooper, S. I.; Henderson, C.; Rumerio, P.; West, C.; Arcaro, D.; Avetisyan, A.; Bose, T.; Gastler, D.; Rankin, D.; Richardson, C.; Rohlf, J.; Sulak, L.; Zou, D.; Benelli, G.; Cutts, D.; Garabedian, A.; Hakala, J.; Heintz, U.; Hogan, J. M.; Kwok, K. H. M.; Laird, E.; Landsberg, G.; Mao, Z.; Narain, M.; Pazzini, J.; Piperov, S.; Sagir, S.; Syarif, R.; Yu, D.; Band, R.; Brainerd, C.; Burns, D.; Calderon De La Barca Sanchez, M.; Chertok, M.; Conway, J.; Conway, R.; Cox, P. T.; Erbacher, R.; Flores, C.; Funk, G.; Gardner, M.; Ko, W.; Lander, R.; Mclean, C.; Mulhearn, M.; Pellett, D.; Pilot, J.; Shalhout, S.; Shi, M.; Smith, J.; Squires, M.; Stolp, D.; Tos, K.; Tripathi, M.; Wang, Z.; Bachtis, M.; Bravo, C.; Cousins, R.; Dasgupta, A.; Florent, A.; Hauser, J.; Ignatenko, M.; Mccoll, N.; Saltzberg, D.; Schnaible, C.; Valuev, V.; Bouvier, E.; Burt, K.; Clare, R.; Ellison, J.; Gary, J. W.; Ghiasi Shirazi, S. M. A.; Hanson, G.; Heilman, J.; Jandir, P.; Kennedy, E.; Lacroix, F.; Long, O. R.; Olmedo Negrete, M.; Paneva, M. I.; Shrinivas, A.; Si, W.; Wei, H.; Wimpenny, S.; Yates, B. R.; Branson, J. G.; Cerati, G. B.; Cittolin, S.; Derdzinski, M.; Gerosa, R.; Hashemi, B.; Holzner, A.; Klein, D.; Kole, G.; Krutelyov, V.; Letts, J.; Macneill, I.; Masciovecchio, M.; Olivito, D.; Padhi, S.; Pieri, M.; Sani, M.; Sharma, V.; Simon, S.; Tadel, M.; Vartak, A.; Wasserbaech, S.; Wood, J.; Würthwein, F.; Yagil, A.; Zevi Della Porta, G.; Amin, N.; Bhandari, R.; Bradmiller-Feld, J.; Campagnari, C.; Dishaw, A.; Dutta, V.; Franco Sevilla, M.; George, C.; Golf, F.; Gouskos, L.; Gran, J.; Heller, R.; Incandela, J.; Mullin, S. D.; Ovcharova, A.; Qu, H.; Richman, J.; Stuart, D.; Suarez, I.; Yoo, J.; Anderson, D.; Bendavid, J.; Bornheim, A.; Lawhorn, J. M.; Newman, H. B.; Nguyen, T.; Pena, C.; Spiropulu, M.; Vlimant, J. R.; Xie, S.; Zhang, Z.; Zhu, R. Y.; Andrews, M. B.; Ferguson, T.; Mudholkar, T.; Paulini, M.; Russ, J.; Sun, M.; Vogel, H.; Vorobiev, I.; Weinberg, M.; Cumalat, J. P.; Ford, W. T.; Jensen, F.; Johnson, A.; Krohn, M.; Leontsinis, S.; Mulholland, T.; Stenson, K.; Wagner, S. R.; Alexander, J.; Chaves, J.; Chu, J.; Dittmer, S.; Mcdermott, K.; Mirman, N.; Patterson, J. R.; Rinkevicius, A.; Ryd, A.; Skinnari, L.; Soffi, L.; Tan, S. M.; Tao, Z.; Thom, J.; Tucker, J.; Wittich, P.; Zientek, M.; Abdullin, S.; Albrow, M.; Apollinari, G.; Apresyan, A.; Apyan, A.; Banerjee, S.; Bauerdick, L. A. T.; Beretvas, A.; Berryhill, J.; Bhat, P. C.; Bolla, G.; Burkett, K.; Butler, J. N.; Canepa, A.; Cheung, H. W. K.; Chlebana, F.; Cremonesi, M.; Duarte, J.; Elvira, V. D.; Freeman, J.; Gecse, Z.; Gottschalk, E.; Gray, L.; Green, D.; Grünendahl, S.; Gutsche, O.; Harris, R. M.; Hasegawa, S.; Hirschauer, J.; Hu, Z.; Jayatilaka, B.; Jindariani, S.; Johnson, M.; Joshi, U.; Klima, B.; Kreis, B.; Lammel, S.; Lincoln, D.; Lipton, R.; Liu, M.; Liu, T.; Lopes De Sá, R.; Lykken, J.; Maeshima, K.; Magini, N.; Marraffino, J. M.; Maruyama, S.; Mason, D.; McBride, P.; Merkel, P.; Mrenna, S.; Nahn, S.; O'Dell, V.; Pedro, K.; Prokofyev, O.; Rakness, G.; Ristori, L.; Schneider, B.; Sexton-Kennedy, E.; Soha, A.; Spalding, W. J.; Spiegel, L.; Stoynev, S.; Strait, J.; Strobbe, N.; Taylor, L.; Tkaczyk, S.; Tran, N. V.; Uplegger, L.; Vaandering, E. W.; Vernieri, C.; Verzocchi, M.; Vidal, R.; Wang, M.; Weber, H. A.; Whitbeck, A.; Acosta, D.; Avery, P.; Bortignon, P.; Brinkerhoff, A.; Carnes, A.; Carver, M.; Curry, D.; Das, S.; Field, R. D.; Furic, I. K.; Konigsberg, J.; Korytov, A.; Kotov, K.; Ma, P.; Matchev, K.; Mei, H.; Mitselmakher, G.; Rank, D.; Sperka, D.; Terentyev, N.; Thomas, L.; Wang, J.; Wang, S.; Yelton, J.; Joshi, Y. R.; Linn, S.; Markowitz, P.; Martinez, G.; Rodriguez, J. L.; Ackert, A.; Adams, T.; Askew, A.; Hagopian, S.; Hagopian, V.; Johnson, K. F.; Kolberg, T.; Perry, T.; Prosper, H.; Santra, A.; Yohay, R.; Baarmand, M. M.; Bhopatkar, V.; Colafranceschi, S.; Hohlmann, M.; Noonan, D.; Roy, T.; Yumiceva, F.; Adams, M. R.; Apanasevich, L.; Berry, D.; Betts, R. R.; Cavanaugh, R.; Chen, X.; Evdokimov, O.; Gerber, C. E.; Hangal, D. A.; Hofman, D. J.; Jung, K.; Kamin, J.; Sandoval Gonzalez, I. D.; Tonjes, M. B.; Trauger, H.; Varelas, N.; Wang, H.; Wu, Z.; Zhang, J.; Bilki, B.; Clarida, W.; Dilsiz, K.; Durgut, S.; Gandrajula, R. P.; Haytmyradov, M.; Khristenko, V.; Merlo, J.-P.; Mermerkaya, H.; Mestvirishvili, A.; Moeller, A.; Nachtman, J.; Ogul, H.; Onel, Y.; Ozok, F.; Penzo, A.; Snyder, C.; Tiras, E.; Wetzel, J.; Yi, K.; Blumenfeld, B.; Cocoros, A.; Eminizer, N.; Fehling, D.; Feng, L.; Gritsan, A. V.; Maksimovic, P.; Roskes, J.; Sarica, U.; Swartz, M.; Xiao, M.; You, C.; Al-bataineh, A.; Baringer, P.; Bean, A.; Boren, S.; Bowen, J.; Castle, J.; Khalil, S.; Kropivnitskaya, A.; Majumder, D.; Mcbrayer, W.; Murray, M.; Royon, C.; Sanders, S.; Schmitz, E.; Stringer, R.; Tapia Takaki, J. D.; Wang, Q.; Ivanov, A.; Kaadze, K.; Maravin, Y.; Mohammadi, A.; Saini, L. K.; Skhirtladze, N.; Toda, S.; Rebassoo, F.; Wright, D.; Anelli, C.; Baden, A.; Baron, O.; Belloni, A.; Calvert, B.; Eno, S. C.; Ferraioli, C.; Hadley, N. J.; Jabeen, S.; Jeng, G. Y.; Kellogg, R. G.; Kunkle, J.; Mignerey, A. C.; Ricci-Tam, F.; Shin, Y. H.; Skuja, A.; Tonwar, S. C.; Abercrombie, D.; Allen, B.; Azzolini, V.; Barbieri, R.; Baty, A.; Bi, R.; Brandt, S.; Busza, W.; Cali, I. A.; D'Alfonso, M.; Demiragli, Z.; Gomez Ceballos, G.; Goncharov, M.; Hsu, D.; Iiyama, Y.; Innocenti, G. M.; Klute, M.; Kovalskyi, D.; Lai, Y. S.; Lee, Y.-J.; Levin, A.; Luckey, P. D.; Maier, B.; Marini, A. C.; Mcginn, C.; Mironov, C.; Narayanan, S.; Niu, X.; Paus, C.; Roland, C.; Roland, G.; Salfeld-Nebgen, J.; Stephans, G. S. F.; Tatar, K.; Velicanu, D.; Wang, J.; Wang, T. W.; Wyslouch, B.; Benvenuti, A. C.; Chatterjee, R. M.; Evans, A.; Hansen, P.; Kalafut, S.; Kubota, Y.; Lesko, Z.; Mans, J.; Nourbakhsh, S.; Ruckstuhl, N.; Rusack, R.; Turkewitz, J.; Acosta, J. G.; Oliveros, S.; Avdeeva, E.; Bloom, K.; Claes, D. R.; Fangmeier, C.; Gonzalez Suarez, R.; Kamalieddin, R.; Kravchenko, I.; Monroy, J.; Siado, J. E.; Snow, G. R.; Stieger, B.; Alyari, M.; Dolen, J.; Godshalk, A.; Harrington, C.; Iashvili, I.; Nguyen, D.; Parker, A.; Rappoccio, S.; Roozbahani, B.; Alverson, G.; Barberis, E.; Hortiangtham, A.; Massironi, A.; Morse, D. M.; Nash, D.; Orimoto, T.; Teixeira De Lima, R.; Trocino, D.; Wang, R.-J.; Wood, D.; Bhattacharya, S.; Charaf, O.; Hahn, K. A.; Mucia, N.; Odell, N.; Pollack, B.; Schmitt, M. H.; Sung, K.; Trovato, M.; Velasco, M.; Dev, N.; Hildreth, M.; Hurtado Anampa, K.; Jessop, C.; Karmgard, D. J.; Kellams, N.; Lannon, K.; Loukas, N.; Marinelli, N.; Meng, F.; Mueller, C.; Musienko, Y.; Planer, M.; Reinsvold, A.; Ruchti, R.; Smith, G.; Taroni, S.; Wayne, M.; Wolf, M.; Woodard, A.; Alimena, J.; Antonelli, L.; Bylsma, B.; Durkin, L. S.; Flowers, S.; Francis, B.; Hart, A.; Hill, C.; Ji, W.; Liu, B.; Luo, W.; Puigh, D.; Winer, B. L.; Wulsin, H. W.; Benaglia, A.; Cooperstein, S.; Driga, O.; Elmer, P.; Hardenbrook, J.; Hebda, P.; Lange, D.; Luo, J.; Marlow, D.; Mei, K.; Ojalvo, I.; Olsen, J.; Palmer, C.; Piroué, P.; Stickland, D.; Svyatkovskiy, A.; Tully, C.; Malik, S.; Norberg, S.; Barker, A.; Barnes, V. E.; Folgueras, S.; Gutay, L.; Jha, M. K.; Jones, M.; Jung, A. W.; Khatiwada, A.; Miller, D. H.; Neumeister, N.; Schulte, J. F.; Sun, J.; Wang, F.; Xie, W.; Cheng, T.; Parashar, N.; Stupak, J.; Adair, A.; Akgun, B.; Chen, Z.; Ecklund, K. M.; Geurts, F. J. M.; Guilbaud, M.; Li, W.; Michlin, B.; Northup, M.; Padley, B. P.; Roberts, J.; Rorie, J.; Tu, Z.; Zabel, J.; Bodek, A.; de Barbaro, P.; Demina, R.; Duh, Y. t.; Ferbel, T.; Galanti, M.; Garcia-Bellido, A.; Han, J.; Hindrichs, O.; Khukhunaishvili, A.; Lo, K. H.; Tan, P.; Verzetti, M.; Ciesielski, R.; Goulianos, K.; Mesropian, C.; Agapitos, A.; Chou, J. P.; Gershtein, Y.; Gómez Espinosa, T. A.; Halkiadakis, E.; Heindl, M.; Hughes, E.; Kaplan, S.; Kunnawalkam Elayavalli, R.; Kyriacou, S.; Lath, A.; Montalvo, R.; Nash, K.; Osherson, M.; Saka, H.; Salur, S.; Schnetzer, S.; Sheffield, D.; Somalwar, S.; Stone, R.; Thomas, S.; Thomassen, P.; Walker, M.; Foerster, M.; Heideman, J.; Riley, G.; Rose, K.; Spanier, S.; Thapa, K.; Bouhali, O.; Castaneda Hernandez, A.; Celik, A.; Dalchenko, M.; De Mattia, M.; Delgado, A.; Dildick, S.; Eusebi, R.; Gilmore, J.; Huang, T.; Kamon, T.; Mueller, R.; Pakhotin, Y.; Patel, R.; Perloff, A.; Perniè, L.; Rathjens, D.; Safonov, A.; Tatarinov, A.; Ulmer, K. A.; Akchurin, N.; Damgov, J.; De Guio, F.; Dudero, P. R.; Faulkner, J.; Gurpinar, E.; Kunori, S.; Lamichhane, K.; Lee, S. W.; Libeiro, T.; Peltola, T.; Undleeb, S.; Volobouev, I.; Wang, Z.; Greene, S.; Gurrola, A.; Janjam, R.; Johns, W.; Maguire, C.; Melo, A.; Ni, H.; Sheldon, P.; Tuo, S.; Velkovska, J.; Xu, Q.; Arenton, M. W.; Barria, P.; Cox, B.; Hirosky, R.; Ledovskoy, A.; Li, H.; Neu, C.; Sinthuprasith, T.; Sun, X.; Wang, Y.; Wolfe, E.; Xia, F.; Clarke, C.; Harr, R.; Karchin, P. E.; Sturdy, J.; Zaleski, S.; Buchanan, J.; Caillol, C.; Dasu, S.; Dodd, L.; Duric, S.; Gomber, B.; Grothe, M.; Herndon, M.; Hervé, A.; Hussain, U.; Klabbers, P.; Lanaro, A.; Levine, A.; Long, K.; Loveless, R.; Pierro, G. A.; Polese, G.; Ruggles, T.; Savin, A.; Smith, N.; Smith, W. H.; Taylor, D.; Woods, N.

2018-04-01

Normalized differential cross sections for top quark pair production are measured in the dilepton (e+e-, μ + μ -, and μ ∓e±) decay channels in proton-proton collisions at a center-of-mass energy of 13 TeV. The measurements are performed with data corresponding to an integrated luminosity of 2.1 fb-1 using the CMS detector at the LHC. The cross sections are measured differentially as a function of the kinematic properties of the leptons, jets from bottom quark hadronization, top quarks, and top quark pairs at the particle and parton levels. The results are compared to several Monte Carlo generators that implement calculations up to next-to-leading order in perturbative quantum chromodynamics interfaced with parton showering, and also to fixed-order theoretical calculations of top quark pair production up to next-to-next-to-leading order. [Figure not available: see fulltext.

Turn It Off: An Action Research Study of Top Management Influence on Energy Conservation in the Workplace

PubMed Central

Russell, Sally V.; Evans, Alice; Fielding, Kelly S.; Hill, Christopher

2016-01-01

This paper reports the results of an intervention study that aimed to encourage workplace energy conservation behavior by office-based employees. Taking a co-production approach we worked with the participating organization to design and implement an intervention that used the influence of top management commitment and prompts to encourage workplace energy reduction. Whilst past research has shown top management is related to workplace pro-environmental behavior, this study extends this work by examining a field-based intervention over a longitudinal period. The efficacy of the intervention was measured using observational and self-reported data over a period of 6 months. Results showed that there were significant changes in objective and self-reported energy conservation behavior, perceived top management commitment, organizational culture, norms, and knowledge regarding energy conservation behavior over the course of the study. The findings also demonstrated that the intervention was most successful for those behaviors where employees have individual responsibility. Implications for future research and practice are discussed. PMID:27047417

Measurement of normalized differential $$\\mathrm{t}\\overline{\\mathrm{t}}$$ cross sections in the dilepton channel from pp collisions at $$\\sqrt{s} =$$ 13 TeV

DOE PAGES

Sirunyan, Albert M; et al.

2017-08-25

Normalized differential cross sections for top quark pair production are measured in the dilepton (emore » $^+$e$^-$, $$\\mu^+\\mu^-$$, and $$\\mu^\\mp$$e$$^\\pm$$) decay channels in proton-proton collisions at a center-of-mass energy of 13 TeV. The measurements are performed with data corresponding to an integrated luminosity of 2.1 fb$$^{-1}$$ using the CMS detector at the LHC. The cross sections are measured differentially as a function of the kinematic properties of the leptons, jets from bottom quark hadronization, top quarks, and top quark pairs at the particle and parton levels. The results are compared to several Monte Carlo generators that implement calculations up to next-to-leading order in perturbative quantum chromodynamics interfaced with parton showering, and also to fixed-order theoretical calculations of top quark pair production up to next-to-next-to-leading order.« less

Turn It Off: An Action Research Study of Top Management Influence on Energy Conservation in the Workplace.

PubMed

Russell, Sally V; Evans, Alice; Fielding, Kelly S; Hill, Christopher

2016-01-01

This paper reports the results of an intervention study that aimed to encourage workplace energy conservation behavior by office-based employees. Taking a co-production approach we worked with the participating organization to design and implement an intervention that used the influence of top management commitment and prompts to encourage workplace energy reduction. Whilst past research has shown top management is related to workplace pro-environmental behavior, this study extends this work by examining a field-based intervention over a longitudinal period. The efficacy of the intervention was measured using observational and self-reported data over a period of 6 months. Results showed that there were significant changes in objective and self-reported energy conservation behavior, perceived top management commitment, organizational culture, norms, and knowledge regarding energy conservation behavior over the course of the study. The findings also demonstrated that the intervention was most successful for those behaviors where employees have individual responsibility. Implications for future research and practice are discussed.

International Review of the Development and Implementation of Energy Efficiency Standards and Labeling Programs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, Nan; Zheng, Nina; Fridley, David

2012-02-28

Appliance energy efficiency standards and labeling (S&L) programs have been important policy tools for regulating the efficiency of energy-using products for over 40 years and continue to expand in terms of geographic and product coverage. The most common S&L programs include mandatory minimum energy performance standards (MEPS) that seek to push the market for efficient products, and energy information and endorsement labels that seek to pull the market. This study seeks to review and compare some of the earliest and most well-developed S&L programs in three countries and one region: the U.S. MEPS and ENERGY STAR, Australia MEPS and Energymore » Label, European Union MEPS and Ecodesign requirements and Energy Label and Japanese Top Runner programs. For each program, key elements of S&L programs are evaluated and comparative analyses across the programs undertaken to identify best practice examples of individual elements as well as cross-cutting factors for success and lessons learned in international S&L program development and implementation. The international review and comparative analysis identified several overarching themes and highlighted some common factors behind successful program elements. First, standard-setting and programmatic implementation can benefit significantly from a legal framework that stipulates a specific timeline or schedule for standard-setting and revision, product coverage and legal sanctions for non-compliance. Second, the different MEPS programs revealed similarities in targeting efficiency gains that are technically feasible and economically justified as the principle for choosing a standard level, in many cases at a level that no product on the current market could reach. Third, detailed survey data such as the U.S. Residential Energy Consumption Survey (RECS) and rigorous analyses provide a strong foundation for standard-setting while incorporating the participation of different groups of stakeholders further strengthen the process. Fourth, sufficient program resources for program implementation and evaluation are critical to the effectiveness of standards and labeling programs and cost-sharing between national and local governments can help ensure adequate resources and uniform implementation. Lastly, check-testing and punitive measures are important forms of enforcement while the cancellation of registration or product sales-based fines have also proven effective in reducing non-compliance. The international comparative analysis also revealed the differing degree to which the level of government decentralization has influenced S&L programs and while no single country has best practices in all elements of standards and labeling development and implementation, national examples of best practices for specific elements do exist. For example, the U.S. has exemplified the use of rigorous analyses for standard-setting and robust data source with the RECS database while Japan's Top Runner standard-setting principle has motivated manufacturers to exceed targets. In terms of standards implementation and enforcement, Australia has demonstrated success with enforcement given its long history of check-testing and enforcement initiatives while mandatory information-sharing between EU jurisdictions on compliance results is another important enforcement mechanism. These examples show that it is important to evaluate not only the drivers of different paths of standards and labeling development, but also the country-specific context for best practice examples in order to understand how and why certain elements of specific S&L programs have been effective.« less

Personalization and Patient Involvement in Decision Support Systems: Current Trends

PubMed Central

Sacchi, L.; Lanzola, G.; Viani, N.

2015-01-01

Summary Objectives This survey aims at highlighting the latest trends (2012-2014) on the development, use, and evaluation of Information and Communication Technologies (ICT) based decision support systems (DSSs) in medicine, with a particular focus on patient-centered and personalized care. Methods We considered papers published on scientific journals, by querying PubMed and Web of Science™. Included studies focused on the implementation or evaluation of ICT-based tools used in clinical practice. A separate search was performed on computerized physician order entry systems (CPOEs), since they are increasingly embedding patient-tailored decision support. Results We found 73 papers on DSSs (53 on specific ICT tools) and 72 papers on CPOEs. Although decision support through the delivery of recommendations is frequent (28/53 papers), our review highlighted also DSSs only based on efficient information presentation (25/53). Patient participation in making decisions is still limited (9/53), and mostly focused on risk communication. The most represented medical area is cancer (12%). Policy makers are beginning to be included among stakeholders (6/73), but integration with hospital information systems is still low. Concerning knowledge representation/management issues, we identified a trend towards building inference engines on top of standard data models. Most of the tools (57%) underwent a formal assessment study, even if half of them aimed at evaluating usability and not effectiveness. Conclusions Overall, we have noticed interesting evolutions of medical DSSs to improve communication with the patient, consider the economic and organizational impact, and use standard models for knowledge representation. However, systems focusing on patient-centered care still do not seem to be available at large. PMID:26293857

Integration of a nationally procured electronic health record system into user work practices.

PubMed

Cresswell, Kathrin M; Worth, Allison; Sheikh, Aziz

2012-03-08

Evidence suggests that many small- and medium-scale Electronic Health Record (EHR) implementations encounter problems, these often stemming from users' difficulties in accommodating the new technology into their work practices. There is the possibility that these challenges may be exacerbated in the context of the larger-scale, more standardised, implementation strategies now being pursued as part of major national modernisation initiatives. We sought to understand how England's centrally procured and delivered EHR software was integrated within the work practices of users in selected secondary and specialist care settings. We conducted a qualitative longitudinal case study-based investigation drawing on sociotechnical theory in three purposefully selected sites implementing early functionality of a nationally procured EHR system. The complete dataset comprised semi-structured interview data from a total of 66 different participants, 38.5 hours of non-participant observation of use of the software in context, accompanying researcher field notes, and hospital documents (including project initiation and lessons learnt reports). Transcribed data were analysed thematically using a combination of deductive and inductive approaches, and drawing on NVivo8 software to facilitate coding. The nationally led "top-down" implementation and the associated focus on interoperability limited the opportunity to customise software to local needs. Lack of system usability led users to employ a range of workarounds unanticipated by management to compensate for the perceived shortcomings of the system. These had a number of knock-on effects relating to the nature of collaborative work, patterns of communication, the timeliness and availability of records (including paper) and the ability for hospital management to monitor organisational performance. This work has highlighted the importance of addressing potentially adverse unintended consequences of workarounds associated with the introduction of EHRs. This can be achieved with customisation, which is inevitably somewhat restricted in the context of attempts to implement national solutions. The tensions and potential trade-offs between achieving large-scale interoperability and local requirements is likely to be the subject of continuous debate in England and beyond with no easy answers in sight.

A comprehensive study on pavement edge line implementation : [tech summary].

DOT National Transportation Integrated Search

2014-04-01

Reducing the number of run-o -road (ROR) crashes is a top priority for rural two-lane highways, particularly narrow, rural two-lane : highways. Previous research conducted by the Louisiana Transportation Research Center has concluded that placing ...

Multidisciplinary Team Meetings appear to be effective in Inflammatory Bowel Disease Management: An audit of process and outcomes.

PubMed

Ferman, Mutaz; Lim, Amanda H; Hossain, Monowar; Siow, Glenn W; Andrews, Jane M

2018-05-14

Multidisciplinary team meetings (MDTMs) have proven efficacy in cancer management. Whilst widely implemented in inflammatory bowel disease (IBD) care, their value is yet to be investigated. We reviewed the performance of MDTMs for IBD patients. Retrospective review of MDTMs from March 2013 to July 2016. Each patient's first MDTM was considered. Data collected included: report production and location, disease factors, recommendation(s), implementation and barriers to implementation. The MDTM process was considered successful when at least top-level recommendations were implemented within 6 months. MDTM attendance included IBD gastroenterologist, surgeons, radiologist, nurses, dieticians, psychologists and clinical trial staff. Initial MDTM encounters for 166 patients were reviewed: 86 females; mean age 40 years; 140 (84.3%) with Crohn's disease; mean disease duration 10.8 years (interquartile range 15 years). Electronic reports were filed for all patients; hard copies in 84%. In 151/166 episodes, all (n=127) or top-line (n=24) recommendations were implemented, although there was a delay beyond 6 months in 5. Of 146 patients with a successful MDTM, 85 (58.2%) were in clinical remission at last review (median follow-up 27 months). Amongst patients with unsuccessful MDTMs (n=13), only 2 (15.4%) were in clinical remission at follow-up. Barriers to implementation included patients declining recommendations and loss to follow-up. The majority of MDTM encounters were successful from both a process and clinical outcome perspective. System opportunities to improve the process include ensuring 100% reports are available and addressing implementation delays. Patient factors to address include improved engagement and understanding reasons for declining recommendations. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Interorganizational transfer of technology - A study of adoption of NASA innovations

NASA Technical Reports Server (NTRS)

Chakrabarti, A. K.; Rubenstein, A. H.

1976-01-01

The paper describes a study on the effects of top management support, various techno-economic factors, organizational climate, and decision-making modes on the adoption of NASA innovations. Field research consisted of interviews and questionnaires directed to sixty-five organizations. Forty-five test cases where different decisions for adoption of ideas for new products or processes were made on NASA Tech Briefs were studied in relation to the effects of various factors on the degree of success of adoption, including: (1) the degree of general connection of the technology to the firm's existing operation, (2) the specificity of the relationship between the technology and some existing and recognized problem, (3) the degree of urgency of the problem to which the technology was related, (4) maturity of technology available to implement the technology, (5) availability of personnel and financial resources to implement the technology, (6) degree of top management interest, (7) the use of confrontation in joint-decision, (8) the use of smoothing in decision-making, and (9) the use of forcing in decision-making. It was found that top managements interest was important in the product cases only, and that the success of process innovations was dependent on the quality of information and the specificity of the relationship between the technology and some recognized existing problem.

Technology transfer from biomedical research to clinical practice: measuring innovation performance.

PubMed

Balas, E Andrew; Elkin, Peter L

2013-12-01

Studies documented 17 years of transfer time from clinical trials to practice of care. Launched in 2002, the National Institutes of Health (NIH) translational research initiative needs to develop metrics for impact assessment. A recent White House report highlighted that research and development productivity is declining as a result of increased research spending while the new drugs output is flat. The goal of this study was to develop an expanded model of research-based innovation and performance thresholds of transfer from research to practice. Models for transfer of research to practice have been collected and reviewed. Subsequently, innovation pathways have been specified based on common characteristics. An integrated, intellectual property transfer model is described. The central but often disregarded role of research innovation disclosure is highlighted. Measures of research transfer and milestones of progress have been identified based on the Association of University Technology Managers 2012 performance reports. Numeric milestones of technology transfer are recommended at threshold (top 50%), target (top 25%), and stretch goal (top 10%) performance levels. Transfer measures and corresponding target levels include research spending to disclosure (<$1.88 million), disclosure to patents (>0.81), patents to start-up (>0.1), patents to licenses (>2.25), and average per license income (>$48,000). Several limitations of measurement are described. Academic institutions should take strategic steps to bring innovation to the center of scholarly discussions. Research on research, particularly on pathways to disclosures, is needed to improve R&D productivity. Researchers should be informed about the technology transfer performance of their institution and regulations should better support innovators.

Is strategic asset management applicable to small and medium utilities?

PubMed

Alegre, Helena

2010-01-01

Urban water infrastructures provide essential services to modern societies and represent a major portion of the value of municipal physical assets. Managing these assets rationally is therefore fundamental for the sustainability of the services and to the economy of societies. "Asset Management" (AM) is a modern term for an old practice--assets have always been managed. In recent years, significant evolution occurred in terms of the AM formal approaches, of the monitoring and decision support tools and of the implementation success cases. However, most tools developed are too sophisticated and data seek for small utilities. The European R&D network COST Action C18 ( E-mail: www.costc18.org) identified key research problems related to the management of urban water infrastructures, currently not covered by on-going projects of the European Framework Program. The top 1 topic is "Efficient management of small community". This paper addresses challenges and opportunities for small and medium utilities with regard to infrastructure AM (IAM). To put this into context, the first sections discuss the need for IAM, highlight key recent developments, and present IAM drivers, as well as research and development gaps, priorities and products needed.

Teen pregnancy: an update.

PubMed

McCracken, Katherine A; Loveless, Meredith

2014-10-01

To provide clinicians with a review of recent research and clinically applicable tools regarding teen pregnancy. Teen pregnancy rates have declined but still remain a significant problem in the USA. Teen pregnancy prevention was identified by Centers for Disease Control and Prevention as one of its top six priorities, which is increasing research and intervention data. Long-acting contraceptive methods are acceptable to teens and have been shown to reduce teen birth rates. Pregnant teens need special attention to counseling on pregnancy options and reducing risk during pregnancy with regular prenatal care. Postpartum teens should be encouraged and supported to breastfeed, monitored for depression, and have access to reliable contraception to avoid repeat undesired pregnancy. This review highlights important issues for all providers caring for female adolescents and those who may encounter teen pregnancy. Foremost prevention of teen pregnancy by comprehensive sexual education and access to contraception is the priority. Educating patients and healthcare providers about safety and efficacy of long-acting reversible contraception is a good step to reducing undesired teen pregnancies. Rates of postpartum depression are greater in adolescents than in adults, and adolescent mothers need to be screened and monitored for depression. Strategies to avoid another undesired pregnancy shortly after delivery should be implemented.

Four top tier challenges for Space Weather Research for the next decade

NASA Astrophysics Data System (ADS)

Spann, James

2017-04-01

The science of space weather is that which (1) develops the knowledge and understanding to predict conditions in space that impact life and society, and (2) leads to operational solutions that protect assets and systems to the benefit of society. Advances over the past decades in this area of research have yielded amazing discoveries and significant strides toward fulfilling the promise of an operational solution to space weather, and have facilitated the enterprise to make its way into the realm of national and international policy. Even if the resources, technologies, and political will were available to take advantage of this progress, our current lack of understanding of space weather would prevent the implementation of a fully operational system. This talk will highlight four distinct areas of research that, if fully understood, could enable operational solutions to space weather impacts, given sufficient resources and political will. These areas are (a) trigger of solar variability, (b) acceleration of mass and energy in interplanetary space, (c) geoeffectiveness of solar wind, and (d) ionospheric variability. A brief description, technical challenges, and possible pathways to resolution will be offered for each of these areas.

Minding the Gap: Tapping the Potential of Women to Transform Business. GMAC® Research Report RR-16-01

ERIC Educational Resources Information Center

Bruggeman, Paula; Chan, Hillary

2016-01-01

This white paper, highlights the advancement of women in the workplace, in higher education, and in graduate business education, in particular, and discusses the barriers and obstacles that impede women from progressing to the top levels of business leadership. It offers some thoughts on how changing the gender dynamics in businesses and in…

How the World's Best Schools Stay on Top: Study's Key Findings Pinpoint Practices That Align with Learning Forward

ERIC Educational Resources Information Center

Killion, Joellen

2016-01-01

Key findings from a new study highlight how Learning Forward's long-standing position on professional learning correlates with practices in high-performing systems in Singapore, Shanghai, Hong Kong, and British Columbia. The purpose of this article is to share key findings from the study so that educators might apply them to strengthening…

Interolog interfaces in protein–protein docking

PubMed Central

Alsop, James D.

2015-01-01

ABSTRACT Proteins are essential elements of biological systems, and their function typically relies on their ability to successfully bind to specific partners. Recently, an emphasis of study into protein interactions has been on hot spots, or residues in the binding interface that make a significant contribution to the binding energetics. In this study, we investigate how conservation of hot spots can be used to guide docking prediction. We show that the use of evolutionary data combined with hot spot prediction highlights near‐native structures across a range of benchmark examples. Our approach explores various strategies for using hot spots and evolutionary data to score protein complexes, using both absolute and chemical definitions of conservation along with refinements to these strategies that look at windowed conservation and filtering to ensure a minimum number of hot spots in each binding partner. Finally, structure‐based models of orthologs were generated for comparison with sequence‐based scoring. Using two data sets of 22 and 85 examples, a high rate of top 10 and top 1 predictions are observed, with up to 82% of examples returning a top 10 hit and 35% returning top 1 hit depending on the data set and strategy applied; upon inclusion of the native structure among the decoys, up to 55% of examples yielded a top 1 hit. The 20 common examples between data sets show that more carefully curated interolog data yields better predictions, particularly in achieving top 1 hits. Proteins 2015; 83:1940–1946. © 2015 The Authors. Proteins: Structure, Function, and Bioinformatics Published by Wiley Periodicals, Inc. PMID:25740680

On the Modeling of Thermal Radiation at the Top Surface of a Vacuum Arc Remelting Ingot

NASA Astrophysics Data System (ADS)

Delzant, P.-O.; Baqué, B.; Chapelle, P.; Jardy, A.

2018-02-01

Two models have been implemented for calculating the thermal radiation emitted at the ingot top in the VAR process, namely, a crude model that considers only radiative heat transfer between the free surface and electrode tip and a more detailed model that describes all radiative exchanges between the ingot, electrode, and crucible wall using a radiosity method. From the results of the second model, it is found that the radiative heat flux at the ingot top may depend heavily on the arc gap length and the electrode radius, but remains almost unaffected by variations of the electrode height. Both radiation models have been integrated into a CFD numerical code that simulates the growth and solidification of a VAR ingot. The simulation of a Ti-6-4 alloy melt shows that use of the detailed radiation model leads to some significant modification of the simulation results compared with the simple model. This is especially true during the hot-topping phase, where the top radiation plays an increasingly important role compared with the arc energy input. Thus, while the crude model has the advantage of its simplicity, use of the detailed model should be preferred.

On the Modeling of Thermal Radiation at the Top Surface of a Vacuum Arc Remelting Ingot

NASA Astrophysics Data System (ADS)

Delzant, P.-O.; Baqué, B.; Chapelle, P.; Jardy, A.

2018-06-01

Two models have been implemented for calculating the thermal radiation emitted at the ingot top in the VAR process, namely, a crude model that considers only radiative heat transfer between the free surface and electrode tip and a more detailed model that describes all radiative exchanges between the ingot, electrode, and crucible wall using a radiosity method. From the results of the second model, it is found that the radiative heat flux at the ingot top may depend heavily on the arc gap length and the electrode radius, but remains almost unaffected by variations of the electrode height. Both radiation models have been integrated into a CFD numerical code that simulates the growth and solidification of a VAR ingot. The simulation of a Ti-6-4 alloy melt shows that use of the detailed radiation model leads to some significant modification of the simulation results compared with the simple model. This is especially true during the hot-topping phase, where the top radiation plays an increasingly important role compared with the arc energy input. Thus, while the crude model has the advantage of its simplicity, use of the detailed model should be preferred.

Progress 42 re-entry

NASA Image and Video Library

2011-10-29

ISS029-E-034092 (29 Oct. 2011) --- This unusual photograph, captured by one of the Expedition 29 crew members aboard the International Space Station, highlights the reentry plasma trail (center) of Progress 42P (M-10M) supply vehicle. Progress 42P docked at the space station on April 29, 2011, and was undocked and de-orbited approximately 183 days later on Oct. 29, 2011. The ISS was located over the southern Pacific Ocean when this image was taken. Light from the rising sun illuminates the curvature of the Earth limb (horizon line) at top, but does not completely overwhelm the airglow visible at image top left. Airglow is caused by light emitted at specific wavelengths by atoms and molecules excited by ultraviolet radiation in the upper atmosphere.

Top coat or no top coat for immersion lithography?

NASA Astrophysics Data System (ADS)

Stepanenko, N.; Kim, Hyun-Woo; Kishimura, S.; Van Den Heuvel, D.; Vandenbroeck, N.; Kocsis, M.; Foubert, P.; Maenhoudt, M.; Ercken, M.; Van Roey, F.; Gronheid, R.; Pollentier, I.; Vangoidsenhoven, D.; Delvaux, C.; Baerts, C.; O'Brien, S.; Fyen, W.; Wells, G.

2006-03-01

Since the moment immersion lithography appeared in the roadmaps of IC manufacturers, the question whether to use top coats has become one of the important topics for discussions. The top coats used in immersion lithography have proved to serve as good protectors from leaching of the resist components (PAGs, bases) into the water. However their application complicates the process and may lead to two side effects. First, top coats can affect the process window and resist profile depending on the material's refractive index, thickness, acidity, chemical interaction with the resist and the soaking time. Second, the top coat application may increase the total amount of defects on the wafer. Having an immersion resist which could work without the top coat would be a preferable solution. Still, it is quite challenging to make such a resist as direct water/resist interaction may also result in process window changes, CD variations, generation of additional defects. We have performed a systematic evaluation of a large number of immersion resist and top coat combinations, using the ASML XT:1250Di scanner at IMEC. The samples for the experiments were provided by all the leading resist and top coat suppliers. Particular attention was paid to how the resist and top coat materials from different vendors interacted with each other. Among the factors which could influence the total amount of defects or CD variations on the wafer were: the material's dynamic contact angle and its interaction with the scanner stage speed, top coat thickness and intermixing layer formation, water uptake and leaching. We have examined the importance of all mentioned factors, using such analytical techniques as Resist Development Analyser (RDA), Quartz Crystal Microbalance (QCM), Mass Spectroscopy (MS) and scatterometry. We have also evaluated the influence of the pre- and pos- exposure rinse processes on the defectivity. In this paper we will present the data on imaging and defectivity performance of the resists with and without the use of top coats. So far we can conclude that top coat/resist approach used in immersion lithography needs some more improvements (i.e. process, materials properties) in order to be implemented in high volume manufacturing.

Project-Based Management Development: "The Volvo Story."

ERIC Educational Resources Information Center

Branch, John; Smith, Bryan

1992-01-01

A modular group project-based approach to management development was implemented by Volvo Concessionaires (United Kingdom) in partnership with training consultants. Ingredients of its success included top-level commitment, investment in diagnosis and tailoring, and use of company-specific case studies. (SK)

Novel insights into the apoptosis mechanism of DNA topoisomerase I inhibitor isoliquiritigenin on HCC tumor cell

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Ze-xin; Li, Jian; Li, Yan

The inhibitory effect of DNA topoisomerase (Top I) by isoliquiritigenin(ISO) were investigated and their interaction mechanism was evaluated using methods including UV–vis absorption, fluorescence, coupled with molecular simulation, and using the MTT method of inhibition rate of HCC tumor cell SNU475 proliferation assay, finally, the interaction of ISO with calf thymus DNA was investigated by melting measurements and molecular docking studies. It was found that isoliquiritigenin reversibly inhibited DNA Top I in a competitive manner with the concentrations of ISO resulting in 50% activity lost (IC{sub 50}) were estimated to be 0.178 ± 0.12 mM. Isoliquiritigenin exhibited a strong ability to quench themore » intrinsic fluorescence of Top I through a static quenching procedure. The positive values of enthalpy change and entropy change suggested that the binding of isoliquiritigenin to Top I was driven mainly by hydrophobic interactions. The molecular docking results revealed isoliquiritigenin actually interacted with the primary amino acid residues on the active site of Top I, and the detection results of fluorescence staining and the inhibitory effect on the growth of HCC SUN475 showed that isoliquiritigenin induced the apoptosis cells increased gradually. The interaction of ISO with DNA can cause the denaturation temperature to be increased, which indicated that the stabilization of the DNA helix was increased in the presence of ISO, which indicated that the results provide strong evidence for intercalative binding of ISO with DNA. - Highlights: • ISO reversibly inhibits TOP I activity in an A dose dependent manner. • Hydrophobic interactions play a major role in ISO–TOP I interaction. • ISO has a high affinity close to the active site pocket of TOP I. • The binding of ISO to DNA induces the stability of the structure of DNA.« less

Lake size and fish diversity determine resource use and trophic position of a top predator in high-latitude lakes

PubMed Central

Eloranta, Antti P; Kahilainen, Kimmo K; Amundsen, Per-Arne; Knudsen, Rune; Harrod, Chris; Jones, Roger I

2015-01-01

Prey preference of top predators and energy flow across habitat boundaries are of fundamental importance for structure and function of aquatic and terrestrial ecosystems, as they may have strong effects on production, species diversity, and food-web stability. In lakes, littoral and pelagic food-web compartments are typically coupled and controlled by generalist fish top predators. However, the extent and determinants of such coupling remains a topical area of ecological research and is largely unknown in oligotrophic high-latitude lakes. We analyzed food-web structure and resource use by a generalist top predator, the Arctic charr Salvelinus alpinus (L.), in 17 oligotrophic subarctic lakes covering a marked gradient in size (0.5–1084 km2) and fish species richness (2–13 species). We expected top predators to shift from littoral to pelagic energy sources with increasing lake size, as the availability of pelagic prey resources and the competition for littoral prey are both likely to be higher in large lakes with multispecies fish communities. We also expected top predators to occupy a higher trophic position in lakes with greater fish species richness due to potential substitution of intermediate consumers (prey fish) and increased piscivory by top predators. Based on stable carbon and nitrogen isotope analyses, the mean reliance of Arctic charr on littoral energy sources showed a significant negative relationship with lake surface area, whereas the mean trophic position of Arctic charr, reflecting the lake food-chain length, increased with fish species richness. These results were supported by stomach contents data demonstrating a shift of Arctic charr from an invertebrate-dominated diet to piscivory on pelagic fish. Our study highlights that, because they determine the main energy source (littoral vs. pelagic) and the trophic position of generalist top predators, ecosystem size and fish diversity are particularly important factors influencing function and structure of food webs in high-latitude lakes. PMID:25937909

A distributed Clips implementation: dClips

NASA Technical Reports Server (NTRS)

Li, Y. Philip

1993-01-01

A distributed version of the Clips language, dClips, was implemented on top of two existing generic distributed messaging systems to show that: (1) it is easy to create a coarse-grained parallel programming environment out of an existing language if a high level messaging system is used; and (2) the computing model of a parallel programming environment can be changed easily if we change the underlying messaging system. dClips processes were first connected with a simple master-slave model. A client-server model with intercommunicating agents was later implemented. The concept of service broker is being investigated.

Identification of Drug Characteristics for Implementing Multiregional Clinical Trials Including Japan.

PubMed

Rokuda, Mitsuhiro; Matsumaru, Naoki; Tsukamoto, Katsura

2018-02-01

Multiregional clinical trials (MRCT) are a standard strategy used to improve global drug approval efficiency and the feasibility of clinical trials. Japan is the world's third largest drug market with a unique health care system, making it a key inclusion as an operational region for MRCT (MRCT-JP) for global drug development. We aimed to identify the factors required for efficient drug development by comprehensively reviewing the clinical trials of drugs approved in Japan to identify the factors associated with whether or not MRCT-JP is implemented. We surveyed the review reports and summaries of application data published by the Pharmaceuticals and Medical Devices Agency. We identified drugs for which the clinical trial data package included MRCT-JP and selected the same number of drugs for which the clinical trial data package did not include MRCT-JP from the most recent survey period for comparison. We also examined other publication information, in addition to the review reports, as necessary. The influence of each explanatory variable was analyzed by logistic regression analysis, with whether or not MRCT-JP was implemented as the explanatory variable. Statistical significance was set at 5%. In the survey period up to September 2017, 165 drugs developed with MRCT-JP were approved for manufacture and sale in Japan. "Respiratory system," "inhalation," "biological drug," and "under review" evaluation status for the United States, European Union, and other areas, "approved" evaluation status for the United States, "new ingredients," "priority review," "non-Japanese firm," and "Top 1-10" and "Top 11-20" drug sales rankings for pharmaceutical companies were identified as potential factors leading to the implementation of MRCT-JP. In contrast, "general anti-infectives for systemic use," "various," "external," "chemical compound," "unsubmitted" evaluation status for both the United States and European Union, and "Top 51+" drug sales rankings were potential factors for not implementing MRCT-JP. Therapeutic classification and agent type, in addition to capital type and United States and European Union evaluation status suggested by a previous study, were associated with implementing MRCT-JP. It is important to determine the best way to utilize MRCT-JP to maximize the value of products. Our findings were based on successful cases and may therefore be helpful for designing clinical development plans. Appropriate use of MRCT-JP will improve productivity in the pharmaceutical industry. Copyright © 2018 Elsevier HS Journals, Inc. All rights reserved.

Implementation Strategies for Educational Intranet Resources.

ERIC Educational Resources Information Center

Herson, Katie; Sosabowski, Michael; Lloyd, Andrew; Flowers, Stephen; Paine, Cameron; Newton, Becci

2000-01-01

Describes two alternative strategies for intranet implementation based on experiences at the University of Brighton (United Kingdom). Highlights include differing degrees of staff and student utilization; barriers to success; a unified strategy for effective intranet implementation; and how to manage organizational resistance to change.…

Implementation of an Automated System.

ERIC Educational Resources Information Center

Epstein, Susan Baerg

1983-01-01

Discussion of care and planning given to the implementation of an automated library system highlights informing the staff in the early stages, project management, involvement of the entire staff, the control log, time and money, where and when to go online, and implementation consultants. (EJS)

General purpose pulse shape analysis for fast scintillators implemented in digital readout electronics

NASA Astrophysics Data System (ADS)

Asztalos, Stephen J.; Hennig, Wolfgang; Warburton, William K.

2016-01-01

Pulse shape discrimination applied to certain fast scintillators is usually performed offline. In sufficiently high-event rate environments data transfer and storage become problematic, which suggests a different analysis approach. In response, we have implemented a general purpose pulse shape analysis algorithm in the XIA Pixie-500 and Pixie-500 Express digital spectrometers. In this implementation waveforms are processed in real time, reducing the pulse characteristics to a few pulse shape analysis parameters and eliminating time-consuming waveform transfer and storage. We discuss implementation of these features, their advantages, necessary trade-offs and performance. Measurements from bench top and experimental setups using fast scintillators and XIA processors are presented.

Policy implementation in practice: the case of national service frameworks in general practice.

PubMed

Checkland, Kath; Harrison, Stephen

2004-10-01

National Service Frameworks are an integral part of the government's drive to 'modernise' the NHS, intended to standardise both clinical care and the design of the services used to deliver that clinical care. This article uses evidence from qualitative case studies in three general practices to illustrate the difficulties associated with the implementation of such top-down guidelines and models of service. In these studies it was found that, while there had been little explicit activity directed at implementation overall, the National Service Framework for coronary heart disease had in general fared better than that for older people. Gunn's notion of 'perfect implementation' is used to make sense of the findings.

Organizational Factors that Affect the Implementation of Information Technology: Perspectives of Middle Managers in Iran.

PubMed

Barzekar, Hosein; Karami, Mahtab

2014-10-01

to examine the organizational factors affecting the application of information technology in hospitals. Since the organizational factors are one of the most important determinants of successful projects, by understanding their impact and identifying them it can help planning a systematic IT implementation. In this cross-sectional descriptive study 110 middle managers were chosen from teaching hospitals. Structured questionnaire was used for the data collection. There was a significant relationship between organization resource, organizational knowledge, process, management structure and values and goals with implementation of information technology. Findings showed that organizational factors had a considerable impact on implementation of information technology. Top managers must consider the important aspects of effective organizational factors.

Invited Article: Progress in coherent lithography using table-top extreme ultraviolet lasers

NASA Astrophysics Data System (ADS)

Li, W.; Urbanski, L.; Marconi, M. C.

2015-12-01

Compact (table top) lasers emitting at wavelengths below 50 nm had expanded the spectrum of applications in the extreme ultraviolet (EUV). Among them, the high-flux, highly coherent laser sources enabled lithographic approaches with distinctive characteristics. In this review, we will describe the implementation of a compact EUV lithography system capable of printing features with sub-50 nm resolution using Talbot imaging. This compact system is capable of producing consistent defect-free samples in a reliable and effective manner. Examples of different patterns and structures fabricated with this method will be presented.

Energy-efficient Public Procurement: Best Practice in Program Delivery

DOE Office of Scientific and Technical Information (OSTI.GOV)

Payne, Christopher; Weber, Andrew; Semple, Abby

2013-02-15

This document illustrates the key issues and considerations involved in implementing energy-efficient public procurement. Our primary sources of information have been our partners in the Super Efficient Equipment and Appliance Deployment (SEAD) Initiative Procurement Working Group. Where applicable, we have highlighted specific ways in which working group participants have successfully overcome barriers to delivering effective programs. The following key points emerge from this analysis of programs for energy-efficient public procurement. Lessons for both developed and developing programs are highlighted throughout the guide. 1. Policy: Policy provides the initiative to begin a transition from first cost to life-cycle cost based purchasingmore » methods and culture. Effective policy is well-communicated, establishes accountability from top to bottom of organizations and simplifies the processes necessary to comply. Flexibility and responsiveness are essential in policy development and implementation. Mandatory and voluntary policies may complement one another. 2. Procurement Criteria: Procurement staff must be confident that energy-efficient procurement criteria offer the best long-term value for their organization’s money and represent real environmental gains. Involving multiple stakeholders at the early stages of the criteria creation process can result in greater levels of cooperation from private industry. Criteria should make comparison of products easy for purchasers and require minimal additional calculations. Criteria will need to be regularly updated to reflect market developments. 3. Training: Resources for the creation of training programs are usually very limited, but well-targeted training is necessary in order for a program to be effective. Training must emphasize a process that is efficient for purchasers and simplifies compliance. Purchaser resources and policy must be well designed for training to be effective. Training program development is an excellent opportunity for collaboration amongst public authorities. 4. Procurement Processes: Many tools and guides intended to help buyers comply with energy-efficient procurement policy are designed without detailed knowledge of the procurement process. A deeper understanding of purchasing pathways allows resources to be better directed. Current research by national and international bodies aims to analyze purchasing pathways and can assist in developing future resources.« less

The case for refining bottom-up methane emission inventories using top-down measurements

NASA Astrophysics Data System (ADS)

Kelly, Bryce F. J.; Iverach, Charlotte P.; Ginty, Elisa; Bashir, Safdar; Lowry, Dave; Fisher, Rebecca E.; France, James L.; Nisbet, Euan G.

2017-04-01

Bottom-up global methane emission estimates are important for guiding policy development and mitigation strategies. Such inventories enable rapid and consistent proportioning of emissions by industrial sectors and land use at various scales from city to country to global. There has been limited use of top-down measurements to guide refining emission inventories. Here we compare the EDGAR gridmap data version 4.2 with over 5000 km of daytime ground level mobile atmospheric methane surveys in eastern Australia. The landscapes and industries surveyed include: urban environments, dryland farming, intensive livestock farming (both beef and lamb), irrigation agriculture, open cut and underground coal mining, and coal seam gas production. Daytime mobile methane surveys over a 2-year period show that at the landscape scale there is a high level of repeatability for the mole fraction of methane measured in the ground level atmosphere. Such consistency in the mole fraction of methane indicates that these data can be used as a proxy for flux. A scatter plot of the EDGAR emission gridmap Log[ton substance / 0.1 degree x 0.1 degree / year] versus the median mole fraction of methane / 0.1 degree x 0.1 degree in the ground level atmosphere highlights that the extent of elevated methane emissions associated with coal mining in the Hunter coalfields, which covers an area of 56 km by 24 km, has been under-represented in the EDGAR input data. Our results also show that methane emissions from country towns (population < 100,000) are underestimated in the EDGAR inventory. This is possibly due to poor information on the extent of urban gas leaks. Given the uncertainties associated with the base land use and industry data for each country, we generalise the Australian observations to the global inventory with caution. The extensive comparison of top-down measurements versus the EDGAR version 4.2 methane gridmaps highlights the need for adjustments to the base resource data and/or the emission factors applied for coal mining, especially emissions from underground-mine venting. Also, more detail is required on the areal extent and rate of leakage from the gas distribution systems. This is likely to be the case for many other countries. Our results highlight the value of mobile methane surveys for guiding the refinement of bottom-up emission estimates, and they also suggest the expansion of all forms of top-down emission estimates would result in reduced uncertainty in the global methane budget.

Kernel and System Procedures in Flex.

DTIC Science & Technology

1983-08-01

System procedures on which the operating system for the Flex computer is based. These are the low level rOCedures Whbich are used to implement the compilers, file-store* coummand interpreters etc on Flex. 168 ... System procedures on which the operating system for the Flex computer is based. These are the low level procedures which are used to implement the...privileged mode. They form the interface between the user and a particular operating system written on top of the Kernel.

Design and Implementation of a CMOS Chip for a Prolog

DTIC Science & Technology

1988-03-01

generation scheme . We use the P -circuit [9] with pre-conditioning and post- conditioning 12,3] circuits to generate the carry. The implementation of...system generates vertical microcode for a general purpose processor, the NCR 9300 sys- S tem, from W- code [7]. Three significant pieces of software are...calculation block generating the pro- pagate ( P ) and generate (G) signals needed for carry calculation, and a sum block supplying the final result. The top

A community hospital's journey into Lean Six Sigma.

PubMed

Stuenkel, Kurt; Faulkner, Taunya

2009-01-01

The implementation of Lean Six Sigma and 100-day workouts throughout the 304-bed Floyd Medical Center community hospital organization has led to sustainable results and a marked change in culture. The organization-wide learning of such an effort is deep and intehse, and to remain focused and successful it must be a priority of top management. The workout methodology can assist the organization to carry projects to completion and to achieve rapid implementation of desired improvements.

Incremental cost of implementing residual insecticide treatment with delthametrine on top of intensive routine Aedes aegypti control.

PubMed

Baly, Alberto; Gonzalez, Karelia; Cabrera, Pedro; Popa, Julio C; Toledo, Maria E; Hernandez, Claudia; Montada, Domingo; Vanlerberghe, Veerle; Van der Stuyft, Patrick

2016-05-01

Information on the cost of implementing residual insecticide treatment (RIT) for Aedes control is scarce. We evaluated the incremental cost on top of intensive conventional routine activities of the Aedes control programme (ACP) in the city of Santiago de Cuba, Cuba. We conducted the cost analysis study in 2011-2012, from the perspective of the ACP. Data sources were bookkeeping records, activity registers of the Provincial ACP Centre and the accounts of an RIT implementation study in 21 clusters of on average four house blocks comprising 5180 premises. The annual cost of the routine ACP activities was 19.66 US$ per household. RIT applications in rounds at 4-month intervals covering, on average, 97.2% and using 8.5 g of delthametrine annually per household, cost 3.06 US$ per household per year. Delthametrine comprised 66.5% of this cost; the additional cost for deploying RIT comprised 15.6% of the total ACP routine cost and 27% of the cost related to routine adult stage Aedes control. The incremental cost of implementing RIT is high. It should be weighed against the incremental effect on the burden caused by the array of pathogens transmitted by Aedes. The cost could be reduced if the insecticide became cheaper, by limiting the number of yearly applications or by targeting transmission hot spots. © 2016 John Wiley & Sons Ltd.

Implementing CORAL: An Electronic Resource Management System

ERIC Educational Resources Information Center

Whitfield, Sharon

2011-01-01

A 2010 electronic resource management survey conducted by Maria Collins of North Carolina State University and Jill E. Grogg of University of Alabama Libraries found that the top six electronic resources management priorities included workflow management, communications management, license management, statistics management, administrative…

Transcription profiling suggests that mitochondrial topoisomerase IB acts as a topological barrier and regulator of mitochondrial DNA transcription.

PubMed

Dalla Rosa, Ilaria; Zhang, Hongliang; Khiati, Salim; Wu, Xiaolin; Pommier, Yves

2017-12-08

Mitochondrial DNA (mtDNA) is essential for cell viability because it encodes subunits of the respiratory chain complexes. Mitochondrial topoisomerase IB (TOP1MT) facilitates mtDNA replication by removing DNA topological tensions produced during mtDNA transcription, but it appears to be dispensable. To test whether cells lacking TOP1MT have aberrant mtDNA transcription, we performed mitochondrial transcriptome profiling. To that end, we designed and implemented a customized tiling array, which enabled genome-wide, strand-specific, and simultaneous detection of all mitochondrial transcripts. Our technique revealed that Top1mt KO mouse cells process the mitochondrial transcripts normally but that protein-coding mitochondrial transcripts are elevated. Moreover, we found discrete long noncoding RNAs produced by H-strand transcription and encompassing the noncoding regulatory region of mtDNA in human and murine cells and tissues. Of note, these noncoding RNAs were strongly up-regulated in the absence of TOP1MT. In contrast, 7S DNA, produced by mtDNA replication, was reduced in the Top1mt KO cells. We propose that the long noncoding RNA species in the D-loop region are generated by the extension of H-strand transcripts beyond their canonical stop site and that TOP1MT acts as a topological barrier and regulator for mtDNA transcription and D-loop formation.

Apprenticeship - School Linkage Implementation Manual.

ERIC Educational Resources Information Center

Martin, Sharon T.; And Others

Developed to assist interested sponsors in implementing apprenticeship-school linkage projects, this guide is intended to organize the collective experiences of those who have implemented the demonstration projects to highlight the day-to-day mechanics involved. Section 1 overviews apprenticeship-school linkage. In section 2 factors are described…

Effect of advanced oxidation on N-nitrosodimethylamine (NDMA) formation and microbial ecology during pilot-scale biological activated carbon filtration.

PubMed

Li, Dong; Stanford, Ben; Dickenson, Eric; Khunjar, Wendell O; Homme, Carissa L; Rosenfeldt, Erik J; Sharp, Jonathan O

2017-04-15

Water treatment combining advanced oxidative processes with subsequent exposure to biological activated carbon (BAC) holds promise for the attenuation of recalcitrant pollutants. Here we contrast oxidation and subsequent biofiltration of treated wastewater effluent employing either ozone or UV/H 2 O 2 followed by BAC during pilot-scale implementation. Both treatment trains largely met target water quality goals by facilitating the removal of a suite of trace organics and bulk water parameters. N-nitrosodimethylamine (NDMA) formation was observed in ozone fed BAC columns during biofiltration and to a lesser extent in UV/H 2 O 2 fed columns and was most pronounced at 20 min of empty bed contact time (EBCT) when compared to shorter EBCTs evaluated. While microbial populations were highly similar in the upper reaches, deeper samples revealed a divergence within and between BAC filtration systems where EBCT was identified to be a significant environmental predictor for shifts in microbial populations. The abundance of Nitrospira in the top samples of both columns provides an explanation for the oxidation of nitrite and corresponding increases in nitrate concentrations during BAC transit and support interplay between nitrogen cycling with nitrosamine formation. The results of this study demonstrate that pretreatments using ozone versus UV/H 2 O 2 impart modest differences to the overall BAC microbial population structural and functional attributes, and further highlight the need to evaluate NDMA formation prior to full-scale implementation of BAC in potable reuse applications. Copyright © 2017 Elsevier Ltd. All rights reserved.

Highlights of Conference on Using Student Test Scores to Measure Teacher Performance: The State of the Art in Research and Practice

ERIC Educational Resources Information Center

Guarino, Cassandra; Reckase, Mark D.; Wooldridge, Jeffrey M.

2013-01-01

The push for accountability in public schooling has extended to the measurement of teacher performance, accelerated by federal efforts through Race to the Top. Currently, a large number of states and districts across the country are computing measures of teacher performance based on the standardized test scores of their students and using them to…

China in International Institutions: Challenges and Opportunities for Singapore

DTIC Science & Technology

2011-12-16

Thornton points out that the Chinese civil service is facing increasing competition from the private sector in attracting top graduates. 78 In...demographics and education system, Thornton highlights that China’s civil service faces challenges from the private sector in recruiting and retaining the... private and unofficial” 25 visit to Taiwan, China “expressed strong dissatisfaction with and protest against the visit” and threatened that

Top Down Proteomics Reveals Mature Proteoforms Expressed in Subcellular Fractions of the Echinococcus granulosus Preadult Stage.

PubMed

Lorenzatto, Karina R; Kim, Kyunggon; Ntai, Ioanna; Paludo, Gabriela P; Camargo de Lima, Jeferson; Thomas, Paul M; Kelleher, Neil L; Ferreira, Henrique B

2015-11-06

Echinococcus granulosus is the causative agent of cystic hydatid disease, a neglected zoonosis responsible for high morbidity and mortality. Several molecular mechanisms underlying parasite biology remain poorly understood. Here, E. granulosus subcellular fractions were analyzed by top down and bottom up proteomics for protein identification and characterization of co-translational and post-translational modifications (CTMs and PTMs, respectively). Nuclear and cytosolic extracts of E. granulosus protoscoleces were fractionated by 10% GELFrEE and proteins under 30 kDa were analyzed by LC-MS/MS. By top down analysis, 186 proteins and 207 proteoforms were identified, of which 122 and 52 proteoforms were exclusively detected in nuclear and cytosolic fractions, respectively. CTMs were evident as 71% of the proteoforms had methionine excised and 47% were N-terminal acetylated. In addition, in silico internal acetylation prediction coupled with top down MS allowed the characterization of 9 proteins differentially acetylated, including histones. Bottom up analysis increased the overall number of identified proteins in nuclear and cytosolic fractions to 154 and 112, respectively. Overall, our results provided the first description of the low mass proteome of E. granulosus subcellular fractions and highlighted proteoforms with CTMs and PTMS whose characterization may lead to another level of understanding about molecular mechanisms controlling parasitic flatworm biology.

Characteristics of Highly Cited Articles in Interventional Cardiology.

PubMed

Khan, Muhammad Shahzeb; Usman, Muhammad Shariq; Fatima, Kaneez; Hashmani, Nauman; Siddiqi, Tariq Jamal; Riaz, Haris; Khan, Abdur Rahman; Khosa, Faisal

2017-12-01

Citation classics have been published in many fields of medicine; however, none have focused on interventional cardiology. The goal of this study was to identify the top 100 articles in the field of interventional cardiology and highlight their important trends and characteristics. The Scopus database was used by 2 independent reviewers to extract the top 100 articles using a variety of keywords. We found articles published between 1953 and 2012. Majority (n = 78) of the top 100 articles were published between 1996 and 2010, and the United States was affiliated with the highest number of articles in our list (n = 68). Over half (n = 54) the articles were funded. Private funding was correlated with higher citations (p = 0.036). A third (n = 33) of the papers had authors with conflicts of interest; however, conflict of interest had no effect on citations (p = 0.837). Majority (n = 57) of the articles studied coronary angioplasty and stenting; followed by coronary angiography (n = 14). Women were underrepresented, with only 11 female first authors in the top 100 papers, and only 1 female in the list of top authors who had 5 or more publications. In conclusion, the following features define the typical highly cited article in interventional cardiology-a clinical trial conducted in the United States, which studies angioplasty, and has been published relatively recently in a high-impact journal by a male first author. Copyright © 2017 Elsevier Inc. All rights reserved.

Physical stress modifies top-down and bottom-up forcing on plant growth and reproduction in a coastal ecosystem.

PubMed

Daleo, Pedro; Alberti, Juan; Bruschetti, Carlos Martin; Pascual, Jesos; Iribarne, Oscar; Silliman, Brian R

2015-08-01

Bottom-up and top-down effects act together to exert strong control over plant growth and reproduction, but how physical stress modifies those interactive forces remains unclear. Even though empirical evidence is scarce, theory predicts that the importance of both top-down- and bottom-up forces may decrease as physical stress increases. Here, we experimentally evaluate in the field the separate and interactive effect of salinity, nutrient availability, and crab herbivory on plant above- and belowground biomass, as well as on sexual and clonal reproduction in the salt marsh plant Spartina densiflora. Results show that the outcome of the interaction between nutrient availability and herbivory is highly context dependent, not only varying with the abiotic context (i.e., with or without increased salinity stress), but also with the dependent variable considered. Contrary to theoretical predictions, our results show that, consistently across different measured variables, salinity stress did not cancel bottom-up (i.e., nutrients) or top-down (i.e., consumers) control, but has additive effects. Our results support emerging theory by highlighting that, under many conditions, physical stress can act additively with, or even stimulate, consumer control, especially in cases where the physical stress is only experienced by basal levels of the trophic chain. Abiotic stress, as well as bottom-up and top-down factors, can affect salt marsh structure and function not only by affecting biomass production but also by having other indirect effects, such as changing patterns in plant biomass allocation and reproduction.

What drives successful implementation of pollution prevention and cleaner technology strategy? The role of innovative capability.

PubMed

Bhupendra, Kumar Verma; Sangle, Shirish

2015-05-15

Firms that are dynamic and prepared to implement environmental strategies have a potential competitive advantage over their industry counterparts. Therefore, it is important to understand, what capabilities are required to implement proactive environmental strategies. The paper discusses the attributes of innovative capability required by firms in order to adopt pollution prevention and cleaner technology strategies. Empirical results show that process and behavioral innovativeness are required by firms to implement a pollution prevention strategy. In addition to process and behavioral innovativeness, firms need a top management with high risk-taking ability as well as market, product, and strategic innovativeness to implement a cleaner technology strategy. The paper proposes some important managerial implications on the basis of the above research findings. Copyright © 2015 Elsevier Ltd. All rights reserved.

Essentials of total quality management: a meta-analysis.

PubMed

Mosadeghrad, Ali Mohammad

2014-01-01

The purpose of this paper is to identify critical successful factors for Total Quality Management (TQM) implementation. A literature review was conducted to explore the critical successful factors for TQM implementation between 1980 and 2010. A successful TQM implementation need sufficient education and training, supportive leadership, consistent support of top management, customer focus, employee involvement, process management and continuous improvement of processes. The review was limited to articles written in English language during the past 30 years. From a practical point of view, the findings of this paper provide managers with a practical understanding of the factors that are likely to facilitate TQM implementation in organisations. Understanding the factors that are likely to promote TQM implementation would enable managers to develop more effective strategies that will enhance the chances of achieving business excellence.

ALBERMARLE PAMLICO IR 2002

EPA Science Inventory

The 2002 Albermarle Pamlico Implementation Review (IR) highlights recent successes and challenges with the estuary program. Various components within the IR include: CCMP implementation, outlining priority management actions, public involvement, stakeholder contribution, and limi...

Using IT Governance

ERIC Educational Resources Information Center

Brobst, Jan; Council, Chip

2005-01-01

The discussion in this article is intended to provide an examination of why top management, IT management, and internal auditors should be interested in IT governance. Some aspects of IT management will be described including implementation, auditing, availability, security, and alignment. One governance framework, COBIT, will be utilized as a…

Administrator Insights and Reflections: Technology Integration in Schools

ERIC Educational Resources Information Center

Berrett, Bryan; Murphy, Jennifer; Sullivan, Jamie

2012-01-01

There are numerous technology tools that educators utilize to support student learning. Often, technology is mandated from the top down with school administrators' responsible for overseeing the implementation. Innovative technological approaches to learning often meet resistance within schools. The pervasive culture in education is counteractive…

PAL: Positional Astronomy Library

NASA Astrophysics Data System (ADS)

Jenness, T.; Berry, D. S.

2016-06-01

The PAL library is a partial re-implementation of Pat Wallace's popular SLALIB library written in C using a Gnu GPL license and layered on top of the IAU's SOFA library (or the BSD-licensed ERFA) where appropriate. PAL attempts to stick to the SLA C API where possible.

Quality of Surface Water before Implementation of a Flood-Control Project in Chaska, Minnesota.

DTIC Science & Technology

1981-12-01

reports from 165 authors (Palmer, 1968). Scenedesmus , Oscillatoria, Chlamydomonas, and Ankistrodesmus, all identified in the samples, are in the top 10...SCENEDESMACEAE .... CRUCIGENIA dI 4 ...... 550 11 .... SCENEDESMUS 81 $1 .... 1100# 21 .TETRASPORALES ... COCCOMYXACEAE .. ELAKATOTHRIX ........ 160 3

Optical wireless communication in data centers

NASA Astrophysics Data System (ADS)

Arnon, Shlomi

2018-01-01

In the last decade data centers have become a crucial element in modern human society. However, to keep pace with internet data rate growth, new technologies supporting data center should develop. Integration of optical wireless communication (OWC) in data centers is one of the proposed technologies as augmented technology to the fiber network. One implementation of the OWC technology is deployment of optical wireless transceiver on top of the existing cable/fiber network as extension to the top of rack (TOR) switch; in this way, a dynamic and flexible network is created. Optical wireless communication could reduce energy consumption, increase the data rate, reduce the communication latency, increase flexibility and scalability, and reduce maintenance time and cost, in comparison to extra fiber network deployment. In this paper we review up to date literature in the field, propose an implementation scheme of OWC network, discuss ways to reduce energy consumption by parallel link communication and report preliminary measurement result of university data center environment.

Design of China Leading Energy Efficiency Program (LEP) for equipment and appliances and comparative study of international experience on super-efficient products

NASA Astrophysics Data System (ADS)

Liang, Xiuying; Zhu, Chunyan

2017-11-01

With rising global emphasizes on climate change and sustainable development, how to accelerate the transformation of energy efficiency has become an important question. Designing and implementing energy-efficiency policies for super-efficient products represents an important direction to achieve breakthroughs in the field of energy conservation. On December 31, 2014, China’s National Development and Reform Commission (NDRC) jointly six other ministerial agencies launched China Leading Energy Efficiency Program (LEP), which identifies top efficiency models for selected product categories. LEP sets the highest energy efficiency benchmark. Design of LEP took into consideration of how to best motivate manufacturers to accelerate technical innovation, promote high efficiency products. This paper explains core elements of LEP, such as objectives, selection criteria, implementation method and supportive policies. It also proposes recommendations to further improve LEP through international policy comparison with Japan’s Top Runner Program, U.S. Energy Star Most Efficient, and SEAD Global Efficiency Medal.

The influence of focused-attention meditation states on the cognitive control of sequence learning.

PubMed

Chan, Russell W; Immink, Maarten A; Lushington, Kurt

2017-10-01

Cognitive control processes influence how motor sequence information is utilised and represented. Since cognitive control processes are shared amongst goal-oriented tasks, motor sequence learning and performance might be influenced by preceding cognitive tasks such as focused-attention meditation (FAM). Prior to a serial reaction time task (SRTT), participants completed either a single-session of FAM, a single-session of FAM followed by delay (FAM+) or no meditation (CONTROL). Relative to CONTROL, FAM benefitted performance in early, random-ordered blocks. However, across subsequent sequence learning blocks, FAM+ supported the highest levels of performance improvement resulting in superior performance at the end of the SRTT. Performance following FAM+ demonstrated greater reliance on embedded sequence structures than FAM. These findings illustrate that increased top-down control immediately after FAM biases the implementation of stimulus-based planning. Introduction of a delay following FAM relaxes top-down control allowing for implementation of response-based planning resulting in sequence learning benefits. Copyright © 2017 Elsevier Inc. All rights reserved.

Critical challenges in ERP implementation: A qualitative case study in the Canadian oil and gas industry

NASA Astrophysics Data System (ADS)

Menon, Sreekumar A.

This exploratory qualitative single-case study examines critical challenges encountered during ERP implementation based on individual perspectives in four project roles: senior leaders, project managers, project team members, and business users, all specifically in Canadian oil and gas industry. Data was collected by interviewing participants belonging to these categories, and by analyzing project documentation about ERP implementation. The organization for the case study was a leading multinational oil and gas company having a substantial presence in the energy sector in Canada. The study results were aligned with the six management questions regarding critical challenges in ERP: (a) circumstances to implement ERP, (b) benefits and process improvements achieved, (c) best practices implemented, (d) critical challenges encountered, (e) strategies and mitigating actions used, and (f) recommendations to improve future ERP implementations. The study results highlight six key findings. First, the study provided valid circumstances for implementing ERP systems. Second, the study underscored the importance of benefits and process improvements in ERP implementation. Third, the study highlighted that adoption of best practices is crucial for ERP Implementation. Fourth, the study found that critical challenges are encountered in ERP Implementation and are significant during ERP implementation. Fifth, the study found that strategies and mitigating actions can overcome challenges in ERP implementation. Finally, the study provided ten major recommendations on how to improve future ERP implementations.

Basomedial amygdala mediates top–down control of anxiety and fear

PubMed Central

Adhikari, Avishek; Lerner, Talia N.; Finkelstein, Joel; Pak, Sally; Jennings, Joshua H.; Davidson, Thomas J.; Ferenczi, Emily; Gunaydin, Lisa A.; Mirzabekov, Julie J.; Ye, Li; Kim, Sung-Yon; Lei, Anna; Deisseroth, Karl

2016-01-01

Anxiety-related conditions are among the most difficult neuropsychiatric diseases to treat pharmacologically, but respond to cognitive therapies. There has therefore been interest in identifying relevant top-down pathways from cognitive control regions in medial prefrontal cortex (mPFC). Identification of such pathways could contribute to our understanding of the cognitive regulation of affect, and provide pathways for intervention. Previous studies have suggested that dorsal and ventral mPFC subregions exert opposing effects on fear, as do subregions of other structures. However, precise causal targets for top-down connections among these diverse possibilities have not been established. Here we show that the basomedial amygdala (BMA) represents the major target of ventral mPFC in amygdala in mice. Moreover, BMA neurons differentiate safe and aversive environments, and BMA activation decreases fear-related freezing and high-anxiety states. Lastly, we show that the ventral mPFC–BMA projection implements top-down control of anxiety state and learned freezing, both at baseline and in stress-induced anxiety, defining a broadly relevant new top-down behavioural regulation pathway. PMID:26536109

Trade-Wind Cloudiness and Climate

NASA Technical Reports Server (NTRS)

Randall, David A.

1997-01-01

Closed Mesoscale Cellular Convection (MCC) consists of mesoscale cloud patches separated by narrow clear regions. Strong radiative cooling occurs at the cloud top. A dry two-dimensional Bousinesq model is used to study the effects of cloud-top cooling on convection. Wide updrafts and narrow downdrafts are used to indicate the asymmetric circulations associated with the mesoscale cloud patches. Based on the numerical results, a conceptual model was constructed to suggest a mechanism for the formation of closed MCC over cool ocean surfaces. A new method to estimate the radioative and evaporative cooling in the entrainment layer of a stratocumulus-topped boundary layer has been developed. The method was applied to a set of Large-Eddy Simulation (LES) results and to a set of tethered-balloon data obtained during FIRE. We developed a statocumulus-capped marine mixed layer model which includes a parameterization of drizzle based on the use of a predicted Cloud Condensation Nuclei (CCN) number concentration. We have developed, implemented, and tested a very elaborate new stratiform cloudiness parameterization for use in GCMs. Finally, we have developed a new, mechanistic parameterization of the effects of cloud-top cooling on the entrainment rate.

Antimicrobial use surveillance in broiler chicken flocks in Canada, 2013-2015

PubMed Central

Irwin, Rebecca J.; Reid-Smith, Richard J.

2017-01-01

There is a paucity of data on the reason for and the quantity of antimicrobials used in broiler chickens in Canada. To address this, the Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS) implemented surveillance of antimicrobial use (AMU) and antimicrobial resistance (AMR) in broiler chicken flocks in 2013. Shortly after this (2014), the poultry industry banned the preventive use of ceftiofur in broiler chickens. The objectives of this analysis were to describe antimicrobial use (AMU) in Canadian broiler chickens between 2013 and 2015 (n = 378 flocks), compare these results to other animal species in Canada, to highlight the utility of farm surveillance data to evaluate the impact of a policy change, and to explore how different antimicrobial use metrics might affect data interpretation and communication. The surveillance data indicated that the poultry industry policy resulted in lower antimicrobial use and resistance, and they successfully captured information on when, where, why, and how much antimicrobials were being used. The majority of antimicrobials were administered via the feed (95%). The relative frequency of antimicrobial classes used in broiler chickens differed from those used in swine or in food animal production in general. Coccidiostats were the most frequently used antimicrobial classes (53% of total kg). Excluding coccidiostats, the top three most frequently used antimicrobial classes were bacitracin (53% of flocks), virginiamycin (25%) and avilamycin (21%), mainly used for the prevention of necrotic enteritis. Depending on the AMU metric utilized, the relative rankings of the top antimicrobials changed; hence the choice of the AMU metric is an important consideration for any AMU reporting. When using milligrams/Population Correction Unit (mg/PCU) the top three antimicrobial classes used were bacitracins (76 mg/PCU), trimethoprim-sulfonamides (24 mg/PCU), and penicillins (15 mg/PCU), whereas when using a number of Defined Daily Doses in animals using Canadian standards /1,000 chicken-days at risk (nDDDvetCA/1,000 CD) the ranking was bacitracins (223 nDDDvetCA/1,000 CD), streptogramins (118 nDDDvetCA/1,000 CD), and trimethoprim-sulfonamides (87 nDDDvetCA/1,000 CD). The median animal treatment days in feed for one cycle (ATD/cycle) during the three-year study were 34 ATD/cycle; this was equal to the mean age of the flocks at pre-harvest sampling day (days at risk), indicating that the studied flocks except those that were raised without antibiotics and organic, were fed with medicated rations throughout the observation period. Overall, more than half (59%) of antimicrobials used in broiler chickens were in classes not used in human medicine, such as ionophores and chemical coccidiostats aimed to prevent coccidiosis. Compared to grower-finisher pigs and in production animal species (national sales data), the mg/PCU of antimicrobials used in broiler chickens was relatively lower. The findings of this paper highlighted the importance of farm-level AMU surveillance in measuring the impact of interventions to reduce antimicrobials in poultry. PMID:28658278

Top-tagging at the energy frontier

NASA Astrophysics Data System (ADS)

Han, Zhenyu; Son, Minho; Tweedie, Brock

2018-02-01

At proposed future hadron colliders and in the coming years at the LHC, top quarks will be produced at genuinely multi-TeV energies. Top-tagging at such high energies forces us to confront several new issues in terms of detector capabilities and jet physics. Here, we explore these issues in the context of some simple JHU/CMS-type declustering algorithms and the N -subjettiness jet-shape variable τ32. We first highlight the complementarity between the two tagging approaches at particle level with respect to discriminating top-jets against gluons and quarks, using multivariate optimization scans. We then introduce a basic fast detector simulation, including electromagnetic calorimeter showering patterns determined from GEANT. We consider a number of tricks for processing the fast detector output back to an approximate particle-level picture. Re-optimizing the tagger parameters, we demonstrate that the inevitable losses in discrimination power at very high energies can typically be ameliorated. For example, percent-scale mistag rates might be maintained even in extreme cases where an entire top decay would sit inside of one hadronic calorimeter cell and tracking information is completely absent. We then study three novel physics effects that will come up in the multi-TeV energy regime: gluon radiation off of boosted top quarks, mistags originating from g →t t ¯ , and mistags originating from q →(W /Z )q collinear electroweak splittings with subsequent hadronic decays. The first effect, while nominally a nuisance, can actually be harnessed to slightly improve discrimination against gluons. The second effect can lead to effective O (1 ) enhancements of gluon mistag rates for tight working points. And the third effect, while conceptually interesting, we show to be of highly subleading importance at all energies.

National Computer Security Conference Proceedings (12th): Information Systems Security: Solutions for Today - Concepts for Tomorrow Held in Baltimore, Maryland on 10-13 October 1989

DTIC Science & Technology

1989-10-13

and other non -technical aspects of the system). System-wide Perspective. The systerm that is being designed and engineered must include not just the...specifications and is regarded as the lowest-level (implementation) of detail.-’ Ihis decomposition follows the typical "top down" design methodology ...formal verification process has contributed to the security and correctness of the TCB design and implementation. FORMUL METHODOLOGY DESCRIPTION The

Application guide for universal source encoding for space

NASA Technical Reports Server (NTRS)

Yeh, Pen-Shu; Miller, Warner H.

1993-01-01

Lossless data compression was studied for many NASA missions. The Rice algorithm was demonstrated to provide better performance than other available techniques on most scientific data. A top-level description of the Rice algorithm is first given, along with some new capabilities implemented in both software and hardware forms. Systems issues important for onboard implementation, including sensor calibration, error propagation, and data packetization, are addressed. The latter part of the guide provides twelve case study examples drawn from a broad spectrum of science instruments.

Patterning and templating for nanoelectronics.

PubMed

Galatsis, Kosmas; Wang, Kang L; Ozkan, Mihri; Ozkan, Cengiz S; Huang, Yu; Chang, Jane P; Monbouquette, Harold G; Chen, Yong; Nealey, Paul; Botros, Youssry

2010-02-09

The semiconductor industry will soon be launching 32 nm complementary metal oxide semiconductor (CMOS) technology node using 193 nm lithography patterning technology to fabricate microprocessors with more than 2 billion transistors. To ensure the survival of Moore's law, alternative patterning techniques that offer advantages beyond conventional top-down patterning are aggressively being explored. It is evident that most alternative patterning techniques may not offer compelling advantages to succeed conventional top-down lithography for silicon integrated circuits, but alternative approaches may well indeed offer functional advantages in realising next-generation information processing nanoarchitectures such as those based on cellular, bioinsipired, magnetic dot logic, and crossbar schemes. This paper highlights and evaluates some patterning methods from the Center on Functional Engineered Nano Architectonics in Los Angeles and discusses key benchmarking criteria with respect to CMOS scaling.

A Retrieval of Tropical Latent Heating Using the 3D Structure of Precipitation Features

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ahmed, Fiaz; Schumacher, Courtney; Feng, Zhe

Traditionally, radar-based latent heating retrievals use rainfall to estimate the total column-integrated latent heating and then distribute that heating in the vertical using a model-based look-up table (LUT). In this study, we develop a new method that uses size characteristics of radar-observed precipitating echo (i.e., area and mean echo-top height) to estimate the vertical structure of latent heating. This technique (named the Convective-Stratiform Area [CSA] algorithm) builds on the fact that the shape and magnitude of latent heating profiles are dependent on the organization of convective systems and aims to avoid some of the pitfalls involved in retrieving accurate rainfallmore » amounts and microphysical information from radars and models. The CSA LUTs are based on a high-resolution Weather Research and Forecasting model (WRF) simulation whose domain spans much of the near-equatorial Indian Ocean. When applied to S-PolKa radar observations collected during the DYNAMO/CINDY2011/AMIE field campaign, the CSA retrieval compares well to heating profiles from a sounding-based budget analysis and improves upon a simple rain-based latent heating retrieval. The CSA LUTs also highlight the fact that convective latent heating increases in magnitude and height as cluster area and echo-top heights grow, with a notable congestus signature of cooling at mid levels. Stratiform latent heating is less dependent on echo-top height, but is strongly linked to area. Unrealistic latent heating profiles in the stratiform LUT, viz., a low-level heating spike, an elevated melting layer, and net column cooling were identified and corrected for. These issues highlight the need for improvement in model parameterizations, particularly in linking microphysical phase changes to larger mesoscale processes.« less

Sequencing Larger Intact Proteins (30-70 kDa) with Activated Ion Electron Transfer Dissociation

NASA Astrophysics Data System (ADS)

Riley, Nicholas M.; Westphall, Michael S.; Coon, Joshua J.

2018-01-01

The analysis of intact proteins via mass spectrometry can offer several benefits to proteome characterization, although the majority of top-down experiments focus on proteoforms in a relatively low mass range (<30 kDa). Recent studies have focused on improving the analysis of larger intact proteins (up to 75 kDa), but they have also highlighted several challenges to be addressed. One major hurdle is the efficient dissociation of larger protein ions, which often to do not yield extensive fragmentation via conventional tandem MS methods. Here we describe the first application of activated ion electron transfer dissociation (AI-ETD) to proteins in the 30-70 kDa range. AI-ETD leverages infrared photo-activation concurrent to ETD reactions to improve sequence-informative product ion generation. This method generates more product ions and greater sequence coverage than conventional ETD, higher-energy collisional dissociation (HCD), and ETD combined with supplemental HCD activation (EThcD). Importantly, AI-ETD provides the most thorough protein characterization for every precursor ion charge state investigated in this study, making it suitable as a universal fragmentation method in top-down experiments. Additionally, we highlight several acquisition strategies that can benefit characterization of larger proteins with AI-ETD, including combination of spectra from multiple ETD reaction times for a given precursor ion, multiple spectral acquisitions of the same precursor ion, and combination of spectra from two different dissociation methods (e.g., AI-ETD and HCD). In all, AI-ETD shows great promise as a method for dissociating larger intact protein ions as top-down proteomics continues to advance into larger mass ranges. [Figure not available: see fulltext.

Bridging the Gap between Research and Practice: Implementation Science

ERIC Educational Resources Information Center

Olswang, Lesley B.; Prelock, Patricia A.

2015-01-01

Purpose: This article introduces implementation science, which focuses on research methods that promote the systematic application of research findings to practice. Method: The narrative defines implementation science and highlights the importance of moving research along the pipeline from basic science to practice as one way to facilitate…

The Plasma-Based Instruction in Ethiopia: Utopia or Dystopia?

ERIC Educational Resources Information Center

Abera, Berhanu

2013-01-01

This article highlights the utopian and dystopian viewpoints held on the plasma-based instruction in Ethiopian by looking into the existing literature works and by analyzing attitudes of implementing bodies and implementers towards the program. The article identified that though implementing bodies were enthusiastic in developing and expanding the…

The Process of Creating Integrated Home Care in Lithuania: from Idea to Reality

PubMed Central

Jurkuvienė, Ramunė; Butkevičienė, Rūta; Gajdosikienė, Indrė

2016-01-01

Background: The article presents an analysis of the formulation and implementation of a social innovation: integrated home care (IHC) in post-soviet Lithuania. From 1998 a series of top-down orders to implement IHC were issued, however, home nursing did not start. In 2011 the Ministry of Social Security and Labour began a process to develop integrated home care using new, collaborative processes. The result was 21 pilot projects with well-conceptualized IHC services. Method: Using data from focus groups, interviews, and recorded observations, the research team systematically documented the innovation process, including themes and deviations, employing Smale’s Innovation Trinity framework to organize the larger picture. Results: In the Lithuanian post-totalitarian context, top-down communication was found to be prevalent. Not only IHC, but also openness to change and dialogue at high levels were innovations. Patient-centered practice at local levels could only occur when a new attitude of mind was reached through dialogue with officials at higher levels and between peers. Conclusions: The enactment, rather than the mask of dialogue, participatory program development were critical in the success of IHC innovation. This is difficult to achieve in the light of antiquated public bureaucracies, but in this case, the Ministry team, rather than avoiding the expectation of top-down communication, made it into an asset through promotion of collaboration. PMID:28435419

Next-to-leading-order QCD corrections to Higgs boson production in association with a top quark pair and a jet.

PubMed

van Deurzen, H; Luisoni, G; Mastrolia, P; Mirabella, E; Ossola, G; Peraro, T

2013-10-25

We present the calculation of the cross section for Higgs boson production in association with a top quark pair plus one jet, at next-to-leading-order accuracy in QCD. All mass dependence is retained without recurring to any approximation. After including the complete next-to-leading-order QCD corrections, we observe a strong reduction in the scale dependence of the result. We also show distributions for the invariant mass of the top quark pair, with and without the additional jet, and for the transverse momentum and the pseudorapidity of the Higgs boson. Results for the virtual contributions are obtained with a novel reduction approach based on integrand decomposition via the Laurent expansion, as implemented in the library, NINJA. Cross sections and differential distributions are obtained with an automated setup which combines the GOSAM and SHERPA frameworks.

VA Health Care: Processes to Evaluate, Implement, and Monitor Organizational Structure Changes Needed

DTIC Science & Technology

2016-09-01

VA HEALTH CARE Processes to Evaluate , Implement, and Monitor Organizational Structure Changes Needed Report to...Accountability Office Highlights of GAO-16-803, a report to congressional requesters September 2016 VA HEALTH CARE Processes to Evaluate , Implement, and...recommended organizational structure changes are evaluated to determine appropriate actions and implemented. This is inconsistent with federal standards

Bridging the Gap Between Research and Practice: Implementation Science.

PubMed

Olswang, Lesley B; Prelock, Patricia A

2015-12-01

This article introduces implementation science, which focuses on research methods that promote the systematic application of research findings to practice. The narrative defines implementation science and highlights the importance of moving research along the pipeline from basic science to practice as one way to facilitate evidence-based service delivery. This review identifies challenges in developing and testing interventions in order to achieve widespread adoption in practice settings. A framework for conceptualizing implementation research is provided, including an example to illustrate the application of principles in speech-language pathology. Last, the authors reflect on the status of implementation research in the discipline of communication sciences and disorders. The extant literature highlights the value of implementation science for reducing the gap between research and practice in our discipline. While having unique principles guiding implementation research, many of the challenges and questions are similar to those facing any investigators who are attempting to design valid and reliable studies. This article is intended to invigorate interest in the uniqueness of implementation science among those pursuing both basic and applied research. In this way, it should help ensure the discipline's knowledge base is realized in practice and policy that affects the lives of individuals with communication disorders.

Assessing the influence of component processing and donor characteristics on quality of red cell concentrates using quality control data.

PubMed

Jordan, A; Chen, D; Yi, Q-L; Kanias, T; Gladwin, M T; Acker, J P

2016-07-01

Quality control (QC) data collected by blood services are used to monitor production and to ensure compliance with regulatory standards. We demonstrate how analysis of quality control data can be used to highlight the sources of variability within red cell concentrates (RCCs). We merged Canadian Blood Services QC data with manufacturing and donor records for 28 227 RCC between June 2011 and October 2014. Units were categorized based on processing method, bag manufacturer, donor age and donor sex, then assessed based on product characteristics: haemolysis and haemoglobin levels, unit volume, leucocyte count and haematocrit. Buffy-coat method (top/bottom)-processed units exhibited lower haemolysis than units processed using the whole-blood filtration method (top/top). Units from female donors exhibited lower haemolysis than male donations. Processing method influenced unit volume and the ratio of additive solution to residual plasma. Stored red blood cell characteristics are influenced by prestorage processing and donor factors. Understanding the relationship between processing, donors and RCC quality will help blood services to ensure the safety of transfused products. © 2016 International Society of Blood Transfusion.

Advances in top-down and bottom-up surface nanofabrication: techniques, applications & future prospects.

PubMed

Biswas, Abhijit; Bayer, Ilker S; Biris, Alexandru S; Wang, Tao; Dervishi, Enkeleda; Faupel, Franz

2012-01-15

This review highlights the most significant advances of the nanofabrication techniques reported over the past decade with a particular focus on the approaches tailored towards the fabrication of functional nano-devices. The review is divided into two sections: top-down and bottom-up nanofabrication. Under the classification of top-down, special attention is given to technical reports that demonstrate multi-directional patterning capabilities less than or equal to 100 nm. These include recent advances in lithographic techniques, such as optical, electron beam, soft, nanoimprint, scanning probe, and block copolymer lithography. Bottom-up nanofabrication techniques--such as, atomic layer deposition, sol-gel nanofabrication, molecular self-assembly, vapor-phase deposition and DNA-scaffolding for nanoelectronics--are also discussed. Specifically, we describe advances in the fabrication of functional nanocomposites and graphene using chemical and physical vapor deposition. Our aim is to provide a comprehensive platform for prominent nanofabrication tools and techniques in order to facilitate the development of new or hybrid nanofabrication techniques leading to novel and efficient functional nanostructured devices. Copyright © 2011 Elsevier B.V. All rights reserved.

The Most-Cited Works in Severe Traumatic Brain Injury: A Bibliometric Analysis of the 100 Most-Cited Articles.

PubMed

Li, Lei; Ma, Xiaoye; Pandey, Sajan; Deng, Xianyu; Chen, Songyu; Cui, Daming; Gao, Liang

2018-05-01

There is an abundance of works published on severe traumatic brain injury (sTBI). Bibliometric analyses aim to provide a macroscopic view of research activities regarding sTBI and are helpful in determining the most impactful studies within this field. We performed a generalized search using the database of Web of Science, organized the references by the number of citations, and reviewed full length-articles for the top-100 most-cited articles on sTBI. The articles were classified according to focus. The top-100 articles were cited on average 326.4 times per paper. The Journal of Neurosurgery published the greatest number of top-100 cited articles (9 of 100). Authors from the United States published the majority (67%) of the most-cited articles. The most popular categories were "reviews and guidelines" and "etiology and epidemiology." The present study provides a cross-sectional summary of the 100 most-cited articles on sTBI, highlighting areas of research needing further investigation and development. Copyright © 2018 Elsevier Inc. All rights reserved.

Organizational Factors that Affect the Implementation of Information Technology: Perspectives of Middle Managers in Iran

PubMed Central

Barzekar, Hosein; Karami, Mahtab

2014-01-01

ABSTRACT Objective: to examine the organizational factors affecting the application of information technology in hospitals. Since the organizational factors are one of the most important determinants of successful projects, by understanding their impact and identifying them it can help planning a systematic IT implementation. Methods: In this cross-sectional descriptive study 110 middle managers were chosen from teaching hospitals. Structured questionnaire was used for the data collection. Results: There was a significant relationship between organization resource, organizational knowledge, process, management structure and values and goals with implementation of information technology. Conclusion: Findings showed that organizational factors had a considerable impact on implementation of information technology. Top managers must consider the important aspects of effective organizational factors. PMID:25568582

Implementation and performance of parallel Prolog interpreter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wei, S.; Kale, L.V.; Balkrishna, R.

1988-01-01

In this paper, the authors discuss the implementation of a parallel Prolog interpreter on different parallel machines. The implementation is based on the REDUCE--OR process model which exploits both AND and OR parallelism in logic programs. It is machine independent as it runs on top of the chare-kernel--a machine-independent parallel programming system. The authors also give the performance of the interpreter running a diverse set of benchmark pargrams on parallel machines including shared memory systems: an Alliant FX/8, Sequent and a MultiMax, and a non-shared memory systems: Intel iPSC/32 hypercube, in addition to its performance on a multiprocessor simulation system.

Creating a Speech-Language Pathology Assistant Program.

ERIC Educational Resources Information Center

Hambrecht, Georgia, Ed.; Stimley, Mark, Ed.

This document consists of 11 short articles about the development of the Associate of Science degree program for speech-language pathology assistants (SLPAs) at Indiana State University. The three sections address the program's background, course planning, and program implementation, respectively. Individual articles are: (1) "Top 10 List of…

Safety Systems

ERIC Educational Resources Information Center

Halligan, Tom

2009-01-01

Colleges across the country are rising to the task by implementing safety programs, response strategies, and technologies intended to create a secure environment for teachers and students. Whether it is preparing and responding to a natural disaster, health emergency, or act of violence, more schools are making campus safety a top priority. At…

Keeping Cool in a Crisis

ERIC Educational Resources Information Center

Padgett, Raven

2006-01-01

Many schools are able to avoid disasters by creating a strong, deliberate crisis plan and knowing how to implement it effectively. Good crisis preparedness requires leadership from the top, a critical mass of trained staff members, careful planning, and excellent communication. This article discusses how to prepare for a crisis.

32 CFR 2400.29 - Accountability and control.

Code of Federal Regulations, 2010 CFR

2010-07-01

....29 National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY... serve as Top Secret Control Officer (TSCO) for the Office of Science and Technology Policy and will be...

32 CFR 2400.29 - Accountability and control.

Code of Federal Regulations, 2011 CFR

2011-07-01

....29 National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY... serve as Top Secret Control Officer (TSCO) for the Office of Science and Technology Policy and will be...

32 CFR 2400.29 - Accountability and control.

Code of Federal Regulations, 2012 CFR

2012-07-01

....29 National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY... serve as Top Secret Control Officer (TSCO) for the Office of Science and Technology Policy and will be...

32 CFR 2400.29 - Accountability and control.

Code of Federal Regulations, 2013 CFR

2013-07-01

....29 National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY... serve as Top Secret Control Officer (TSCO) for the Office of Science and Technology Policy and will be...

32 CFR 2400.29 - Accountability and control.

Code of Federal Regulations, 2014 CFR

2014-07-01

....29 National Defense Other Regulations Relating to National Defense OFFICE OF SCIENCE AND TECHNOLOGY POLICY REGULATIONS TO IMPLEMENT E.O. 12356; OFFICE OF SCIENCE AND TECHNOLOGY POLICY INFORMATION SECURITY... serve as Top Secret Control Officer (TSCO) for the Office of Science and Technology Policy and will be...

77 FR 39554 - Self-Regulatory Organizations; NYSE Arca, Inc.; Order Granting Approval of Proposed Rule Change...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-03

... investment objective by implementing a ``top-down'' portfolio management style. This management style begins...'' portfolio management style utilizes a tactical and globally diversified allocation strategy in an attempt to... open-end management investment company.\\4\\ The [[Page 39555

Implementation of a Precast Inverted T-Beam System in Virginia: Part I : Laboratory Investigations

DOT National Transportation Integrated Search

2017-10-01

The inverted T-beam system provides an accelerated bridge construction alternative for short-to-medium-span bridges. The system consists of adjacent precast inverted T-beams with a cast-in-place concrete topping. This bridge system is not expected to...

Wave induced coastal cliff top ground motions and infragravity wave dissipation under high energy wave conditions.

NASA Astrophysics Data System (ADS)

Earlie, C. S.; le Dantec, N.; Young, A.

2016-12-01

Coastal cliff erosion is a widespread problem that threatens property and infrastructure globally. The prediction of this risk calls for robust understanding of the processes and mechanisms involved in causing coastal cliff failure. Over the last decade, a number of geomorphological studies have highlighted the importance of the relationship between the offshore wave climate and cliff-toe water levels, and the resultant coastal response in terms of cliff-top ground motion and erosion. Field-based studies of instantaneous cliff response to direct wave impact have shown that wave-induced loading of the foreshore leads to cliff-top ground motions that may have the potential to weaken the integrity of the rocks and prepare them for failure. In order to understand wave-cliff interaction and how beach morphodynamics influences cliff-top ground motion and cliff erosion, two field experiments were carried out simultaneously at two locations in Northern Brittany (France). This three-month long winter field campaign (Jan-Mar 2016) included, for the first time, a comparison of cliff-top ground motion and cliff erosion at sites fronted by different beach morphologies (reflective/dissipative), along with monitoring of hydrodynamic forcing and beach topography. The magnitude of cliff-top displacements at both sites were dependent on tidal stage and free water surface elevation at the cliff toe, with the greatest contributions of cliff-top ground motions found at infragravity frequencies (0.05-0.005 Hz). Vertical displacements at infragravity and incident sea-swell (0.1-0.5 Hz) frequencies were greater at the dissipative site, apart from during spring high tide and energetic wave conditions, where displacements were two times that at the reflective site. Combining these wave-cliff interaction data with beach morphology and nearshore bathymetry will be key to understanding the spatial variability in cliff erosion under a variety of environmental settings and forcing conditions.

TOP2A and EZH2 Provide Early Detection of an Aggressive Prostate Cancer Subgroup.

PubMed

Labbé, David P; Sweeney, Christopher J; Brown, Myles; Galbo, Phillip; Rosario, Spencer; Wadosky, Kristine M; Ku, Sheng-Yu; Sjöström, Martin; Alshalalfa, Mohammed; Erho, Nicholas; Davicioni, Elai; Karnes, R Jeffrey; Schaeffer, Edward M; Jenkins, Robert B; Den, Robert B; Ross, Ashley E; Bowden, Michaela; Huang, Ying; Gray, Kathryn P; Feng, Felix Y; Spratt, Daniel E; Goodrich, David W; Eng, Kevin H; Ellis, Leigh

2017-11-15

Purpose: Current clinical parameters do not stratify indolent from aggressive prostate cancer. Aggressive prostate cancer, defined by the progression from localized disease to metastasis, is responsible for the majority of prostate cancer-associated mortality. Recent gene expression profiling has proven successful in predicting the outcome of prostate cancer patients; however, they have yet to provide targeted therapy approaches that could inhibit a patient's progression to metastatic disease. Experimental Design: We have interrogated a total of seven primary prostate cancer cohorts ( n = 1,900), two metastatic castration-resistant prostate cancer datasets ( n = 293), and one prospective cohort ( n = 1,385) to assess the impact of TOP2A and EZH2 expression on prostate cancer cellular program and patient outcomes. We also performed IHC staining for TOP2A and EZH2 in a cohort of primary prostate cancer patients ( n = 89) with known outcome. Finally, we explored the therapeutic potential of a combination therapy targeting both TOP2A and EZH2 using novel prostate cancer-derived murine cell lines. Results: We demonstrate by genome-wide analysis of independent primary and metastatic prostate cancer datasets that concurrent TOP2A and EZH2 mRNA and protein upregulation selected for a subgroup of primary and metastatic patients with more aggressive disease and notable overlap of genes involved in mitotic regulation. Importantly, TOP2A and EZH2 in prostate cancer cells act as key driving oncogenes, a fact highlighted by sensitivity to combination-targeted therapy. Conclusions: Overall, our data support further assessment of TOP2A and EZH2 as biomarkers for early identification of patients with increased metastatic potential that may benefit from adjuvant or neoadjuvant targeted therapy approaches. Clin Cancer Res; 23(22); 7072-83. ©2017 AACR . ©2017 American Association for Cancer Research.

Method to implement the CCD timing generator based on FPGA

NASA Astrophysics Data System (ADS)

Li, Binhua; Song, Qian; He, Chun; Jin, Jianhui; He, Lin

2010-07-01

With the advance of the PFPA technology, the design methodology of digital systems is changing. In recent years we develop a method to implement the CCD timing generator based on FPGA and VHDL. This paper presents the principles and implementation skills of the method. Taking a developed camera as an example, we introduce the structure, input and output clocks/signals of a timing generator implemented in the camera. The generator is composed of a top module and a bottom module. The bottom one is made up of 4 sub-modules which correspond to 4 different operation modes. The modules are implemented by 5 VHDL programs. Frame charts of the architecture of these programs are shown in the paper. We also describe implementation steps of the timing generator in Quartus II, and the interconnections between the generator and a Nios soft core processor which is the controller of this generator. Some test results are presented in the end.

Sales Trends in Price-Discounted Cigarettes, Large Cigars, Little Cigars, and Cigarillos-United States, 2011-2016.

PubMed

Wang, Teresa W; Falvey, Kyle; Gammon, Doris G; Loomis, Brett R; Kuiper, Nicole M; Rogers, Todd; King, Brian A

2017-12-15

Tobacco manufacturers continue to implement a range of pricing strategies to increase the affordability and consumption of tobacco products. To demonstrate the extent of retail- and brand-level price discounts at the point of sale, this study assessed national sales trends in price-discounted cigarettes, large cigars, little cigars, and cigarillos. Retail scanner data for tobacco product sales were obtained for convenience stores (C-store) and all-other-outlets-combined (AOC) from September 25, 2011, to January 9, 2016. The proportion of price-discounted sales, average nondiscounted unit price, and average discounted unit price were examined by product category and brand. JoinPoint regression was used to assess average monthly percentage change. Overall, price-discounted sales accounted for 11.3% of cigarette, 3.4% of large cigar, 4.1% of little cigar, and 3.9% of cigarillo sales. The average difference between nondiscounted and discounted prices was 25.5% (C-store) and 36.7% (AOC) for cigarettes; 11.0% (C-store) and 11.2% (AOC) for large cigars; 19.2% (C-store) and 9.6% (AOC) for little cigars; and 5.3% (C-store) and 14.7% (AOC) for cigarillos. Furthermore, price-discounted sales of top-selling tobacco brands comprised up to 36% of cigarette, 7.4% of large cigar, 7.7% of little cigar, and 4.2% of cigarillo unit sales. These findings highlight the use of price discounts by tobacco manufacturers to reduce the cost of cigarettes, large cigars, little cigars, and cigarillos to consumers. These sales patterns underscore the importance of sustained efforts to implement evidence-based strategies to increase prices and reduce availability and consumption of combustible tobacco in the United States. This study highlights the prevalence and provides a baseline of price-discounted cigarettes, large cigars, little cigars, and cigarillos. Surveillance of tobacco sales data, including state-level trends and additional product types, is critical for informing approaches to reduce tobacco consumption. These approaches include countering tobacco product price-discounting practices and raising and maintaining a high sales price for all tobacco products. The implementation of evidence-based population-level interventions, together with local, state, and federal regulation of tobacco products, could prevent tobacco initiation, increase tobacco cessation, and reduce overall tobacco use among US youth and adults. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Contact planarization of ensemble nanowires

NASA Astrophysics Data System (ADS)

Chia, A. C. E.; LaPierre, R. R.

2011-06-01

The viability of four organic polymers (S1808, SC200, SU8 and Cyclotene) as filling materials to achieve planarization of ensemble nanowire arrays is reported. Analysis of the porosity, surface roughness and thermal stability of each filling material was performed. Sonication was used as an effective method to remove the tops of the nanowires (NWs) to achieve complete planarization. Ensemble nanowire devices were fully fabricated and I-V measurements confirmed that Cyclotene effectively planarizes the NWs while still serving the role as an insulating layer between the top and bottom contacts. These processes and analysis can be easily implemented into future characterization and fabrication of ensemble NWs for optoelectronic device applications.

Contact planarization of ensemble nanowires.

PubMed

Chia, A C E; LaPierre, R R

2011-06-17

The viability of four organic polymers (S1808, SC200, SU8 and Cyclotene) as filling materials to achieve planarization of ensemble nanowire arrays is reported. Analysis of the porosity, surface roughness and thermal stability of each filling material was performed. Sonication was used as an effective method to remove the tops of the nanowires (NWs) to achieve complete planarization. Ensemble nanowire devices were fully fabricated and I-V measurements confirmed that Cyclotene effectively planarizes the NWs while still serving the role as an insulating layer between the top and bottom contacts. These processes and analysis can be easily implemented into future characterization and fabrication of ensemble NWs for optoelectronic device applications.

Nonparametric Bayesian Context Learning for Buried Threat Detection

DTIC Science & Technology

2012-01-01

scans of field-collected GPR data collected on dirt (top) and gravel (bottom) lanes at an Eastern US test site. . . . . . . . . . 47 2.11 Plot of ...partition the data into M components, they differ in the information used to partition the data. First, approaches that as- sume independence of observations...and the advantages and disadvantages of using each are discussed. Furthermore, the merits of incorporating spatial information are also highlighted

Advances in Induced Pluripotent Stem Cells, Genomics, Biomarkers, and Antiplatelet Therapy

PubMed Central

Barbato, Emanuele; Lara-Pezzi, Enrique; Stolen, Craig; Taylor, Angela; Barton, Paul J.; Bartunek, Jozef; Iaizzo, Paul; Judge, Daniel P.; Kirshenbaum, Lorrie; Blaxall, Burns C.; Terzic, Andre; Hall, Jennifer L.

2014-01-01

The Journal provides the clinician and scientist with the latest advances in discovery research, emerging technologies, pre-clinical research design and testing, and clinical trials. We highlight advances in areas of induced pluripotent stem cells, genomics, biomarkers, multi-modality imaging and antiplatelet biology and therapy. The top publications are critically discussed and presented along with anatomical reviews and FDA insight to provide context. PMID:24659088

Plate interface rheological switches during subduction infancy: Control on slab penetration and metamorphic sole formation

NASA Astrophysics Data System (ADS)

Agard, P.; Yamato, P.; Soret, M.; Prigent, C.; Guillot, S.; Plunder, A.; Dubacq, B.; Chauvet, A.; Monié, P.

2016-10-01

Subduction infancy corresponds to the first few million years following subduction initiation, when slabs start their descent into the mantle. It coincides with the transient (yet systematic) transfer of material from the top of the slab to the upper plate, as witnessed by metamorphic soles welded beneath obducted ophiolites. Combining structure-lithology-pressure-temperature-time data from metamorphic soles with flow laws derived from experimental rock mechanics, this study highlights two main successive rheological switches across the subduction interface (mantle wedge vs. basalts, then mantle wedge vs. sediments; at ∼800 °C and ∼600 °C, respectively), during which interplate mechanical coupling is maximized by the existence of transiently similar rheologies across the plate contact. We propose that these rheological switches hinder slab penetration and are responsible for slicing the top of the slab and welding crustal pieces (high- then low-temperature metamorphic soles) to the base of the mantle wedge during subduction infancy. This mechanism has implications for the rheological properties of the crust and mantle (and for transient episodes of accretion/exhumation of HP-LT rocks in mature subduction systems) and highlights the role of fluids in enabling subduction to overcome the early resistance to slab penetration.

Projections, plans, policies and politics in Prince George: reflections on five years of climate change adaptation in a northern Canadian community

NASA Astrophysics Data System (ADS)

Picketts, I. M.; Dery, S. J.; Curry, J.

2013-12-01

The City of Prince George, in central British Columbia, Canada, has partnered with academics and collaborators for over five years to address climate change adaptation at the local level. The first phase of research involved conducting a detailed overview of past climate trends and future projections for the region using the outputs of GCMs and downscaled RCMs. This information was communicated to senior local staff and community members, and feedback was applied to create a detailed adaptation strategy for the City, which identified priority impacts and outlined potential strategies to address them at the local level. The top priority impacts for Prince George are forest changes, increased flooding, and impacts to transportation infrastructure. During a second implementation phase of the project, eight local initiatives were completed focusing on: incorporating adaptation into a local sustainability plan and land use plan; exploring impacts related to forests, flooding and transportation infrastructure; and assessing trends and projections in freeze-thaw cycles and heavy rainfall events. This presentation will outline the adaptation initiatives undertaken in the City of Prince George during the second phase of research, and evaluate their effectiveness through reflections from interviews with local planners, engineers, managers, community champions and politicians. The initiatives deemed to be most successful - and most likely to be implemented - focus on topics that: are of high public concern; have clear cost implications; incorporate adaptation into policy; and/or incorporate adaptation into an ongoing project. Outcomes highlight challenges local researchers, practitioners and leaders face as they strive to implement proactive adaptation measures in policy and practice without strong support from policy and professional practices, and with a paucity of successful case study examples to build upon. Outcomes also reveal challenges as municipalities strive to do ';more with less' and work within the reality that adaptation is not generally a high public or political priority. Internal capacity and external support are vital for adaptation success at the local level.

Teamwork for Oversight of Processes and Systems (TOPS). Implementation guide for TOPS version 2.0, 10 August 1992

NASA Technical Reports Server (NTRS)

Strand, Albert A.; Jackson, Darryl J.

1992-01-01

As the nation redefines priorities to deal with a rapidly changing world order, both government and industry require new approaches for oversight of management systems, particularly for high technology products. Declining defense budgets will lead to significant reductions in government contract management personnel. Concurrently, defense contractors are reducing administrative and overhead staffing to control costs. These combined pressures require bold approaches for the oversight of management systems. In the Spring of 1991, the DPRO and TRW created a Process Action Team (PAT) to jointly prepare a Performance Based Management (PBM) system titled Teamwork for Oversight of Processes and Systems (TOPS). The primary goal is implementation of a performance based management system based on objective data to review critical TRW processes with an emphasis on continuous improvement. The processes are: Finance and Business Systems, Engineering and Manufacturing Systems, Quality Assurance, and Software Systems. The team established a number of goals: delivery of quality products to contractual terms and conditions; ensure that TRW management systems meet government guidance and good business practices; use of objective data to measure critical processes; elimination of wasteful/duplicative reviews and audits; emphasis on teamwork--all efforts must be perceived to add value by both sides and decisions are made by consensus; and synergy and the creation of a strong working trust between TRW and the DPRO. TOPS permits the adjustment of oversight resources when conditions change or when TRW systems performance indicate either an increase or decrease in surveillance is appropriate. Monthly Contractor Performance Assessments (CPA) are derived from a summary of supporting system level and process-level ratings obtained from objective process-level data. Tiered, objective, data-driven metrics are highly successful in achieving a cooperative and effective method of measuring performance. The teamwork-based culture developed by TOPS proved an unequaled success in removing adversarial relationships and creating an atmosphere of continuous improvement in quality processes at TRW. The new working relationship does not decrease the responsibility or authority of the DPRO to ensure contract compliance and it permits both parties to work more effectively to improve total quality and reduce cost. By emphasizing teamwork in developing a stronger approach to efficient management of the defense industrial base TOPS is a singular success.

Efficiently Selecting the Best Web Services

NASA Astrophysics Data System (ADS)

Goncalves, Marlene; Vidal, Maria-Esther; Regalado, Alfredo; Yacoubi Ayadi, Nadia

Emerging technologies and linking data initiatives have motivated the publication of a large number of datasets, and provide the basis for publishing Web services and tools to manage the available data. This wealth of resources opens a world of possibilities to satisfy user requests. However, Web services may have similar functionality and assess different performance; therefore, it is required to identify among the Web services that satisfy a user request, the ones with the best quality. In this paper we propose a hybrid approach that combines reasoning tasks with ranking techniques to aim at the selection of the Web services that best implement a user request. Web service functionalities are described in terms of input and output attributes annotated with existing ontologies, non-functionality is represented as Quality of Services (QoS) parameters, and user requests correspond to conjunctive queries whose sub-goals impose restrictions on the functionality and quality of the services to be selected. The ontology annotations are used in different reasoning tasks to infer service implicit properties and to augment the size of the service search space. Furthermore, QoS parameters are considered by a ranking metric to classify the services according to how well they meet a user non-functional condition. We assume that all the QoS parameters of the non-functional condition are equally important, and apply the Top-k Skyline approach to select the k services that best meet this condition. Our proposal relies on a two-fold solution which fires a deductive-based engine that performs different reasoning tasks to discover the services that satisfy the requested functionality, and an efficient implementation of the Top-k Skyline approach to compute the top-k services that meet the majority of the QoS constraints. Our Top-k Skyline solution exploits the properties of the Skyline Frequency metric and identifies the top-k services by just analyzing a subset of the services that meet the non-functional condition. We report on the effects of the proposed reasoning tasks, the quality of the top-k services selected by the ranking metric, and the performance of the proposed ranking techniques. Our results suggest that the number of services can be augmented by up two orders of magnitude. In addition, our ranking techniques are able to identify services that have the best values in at least half of the QoS parameters, while the performance is improved.

Teamwork for Oversight of Processes and Systems (TOPS). Implementation guide for TOPS version 2.0, 10 August 1992

NASA Astrophysics Data System (ADS)

Strand, Albert A.; Jackson, Darryl J.

As the nation redefines priorities to deal with a rapidly changing world order, both government and industry require new approaches for oversight of management systems, particularly for high technology products. Declining defense budgets will lead to significant reductions in government contract management personnel. Concurrently, defense contractors are reducing administrative and overhead staffing to control costs. These combined pressures require bold approaches for the oversight of management systems. In the Spring of 1991, the DPRO and TRW created a Process Action Team (PAT) to jointly prepare a Performance Based Management (PBM) system titled Teamwork for Oversight of Processes and Systems (TOPS). The primary goal is implementation of a performance based management system based on objective data to review critical TRW processes with an emphasis on continuous improvement. The processes are: Finance and Business Systems, Engineering and Manufacturing Systems, Quality Assurance, and Software Systems. The team established a number of goals: delivery of quality products to contractual terms and conditions; ensure that TRW management systems meet government guidance and good business practices; use of objective data to measure critical processes; elimination of wasteful/duplicative reviews and audits; emphasis on teamwork--all efforts must be perceived to add value by both sides and decisions are made by consensus; and synergy and the creation of a strong working trust between TRW and the DPRO. TOPS permits the adjustment of oversight resources when conditions change or when TRW systems performance indicate either an increase or decrease in surveillance is appropriate. Monthly Contractor Performance Assessments (CPA) are derived from a summary of supporting system level and process-level ratings obtained from objective process-level data. Tiered, objective, data-driven metrics are highly successful in achieving a cooperative and effective method of measuring performance. The teamwork-based culture developed by TOPS proved an unequaled success in removing adversarial relationships and creating an atmosphere of continuous improvement in quality processes at TRW. The new working relationship does not decrease the responsibility or authority of the DPRO to ensure contract compliance and it permits both parties to work more effectively to improve total quality and reduce cost. By emphasizing teamwork in developing a stronger approach to efficient management of the defense industrial base TOPS is a singular success.

A 'movement for improvement'? A qualitative study of the adoption of social movement strategies in the implementation of a quality improvement campaign.

PubMed

Waring, Justin; Crompton, Amanda

2017-09-01

Given the difficulties of implementing 'top-down' quality improvements, health service leaders have turned to methods that empower clinicians to co-produce 'bottom-up' improvements. This has involved the adoption of strategies and activities associated with social movements, with clinicians encouraged to participate in collective action towards the shared goal of improvement. This paper examines the adoption of social movement methods by hospital managers as a strategy for implementing a quality improvement 'campaign'. Our case study suggests that, despite the claim of empowering clinicians to develop 'bottom-up' improvements, the use of social movement methods can be more narrowly concerned with engaging clinicians in pre-determined programmes of 'top-down' change. It finds a prominent role for 'hybrid' clinical leaders and other staff representatives in the mobilisation of the campaign, especially for enrolling clinicians in change activities. The work of these 'hybrids' suggests some degree of creative mediation between clinical and managerial interests, but more often alignment with the aspirations of management. The study raises questions about the translation of social movement's theories as a strategy for managing change and re-inventing professionalism. © 2017 The Authors. Sociology of Health & Illness published by John Wiley & Sons Ltd on behalf of Foundation for SHIL.

Charting New Territory: Early Implementation of the Workforce Investment Act. Field Report Series.

ERIC Educational Resources Information Center

Buck, Maria L.

This report highlights issues for policymakers and provides guidance to states and localities implementing the Workforce Investment Act of 1998 (WIA) by describing the successes and struggles of five cities implementing the new legislation. It presents WIA's basic framework and discusses its impact on these four major audiences: employment and…

77 FR 24933 - Notice of Proposed Information Collection Requests; Office of the Secretary; Race to the Top...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-26

... on their progress in the four core education reform areas and in Science, Technology, Engineering..., and ensuring student preparation for success in college and careers; and implementing ambitious plans... reform areas and in Science, Technology, Engineering, and Mathematics. This reporting includes narrative...

Management by Objectives: When and How Does it Work?

ERIC Educational Resources Information Center

DeFee, Dallas T.

1977-01-01

According to the author, management by objectives (formal goal setting and review) depends a great deal on the kinds of goals the organization has and the commitment of top management to the process. He discusses its potential advantages and disadvantages, conditions for adopting it, and successful implementation. (JT)

Performance-Based Evaluation and School Librarians

ERIC Educational Resources Information Center

Church, Audrey P.

2015-01-01

Evaluation of instructional personnel is standard procedure in our Pre-K-12 public schools, and its purpose is to document educator effectiveness. With Race to the Top and No Child Left Behind waivers, states are required to implement performance-based evaluations that demonstrate student academic progress. This three-year study describes the…

Talent Management Programmes at British, American and Canadian Universities: Comparative Study

ERIC Educational Resources Information Center

Boichenko, Maryna

2015-01-01

The article deals with the peculiarities of talent management programmes implementation at the top British, American and Canadian universities. The essence of the main concepts of research--talent and talent management--has been revealed. Talent management is referred to as the systematic attraction, identification, development, engagement,…

The Changing Human Resources Function. Report Number 950.

ERIC Educational Resources Information Center

Freedman, Audrey

The role of the top human resources executive in major corporations has changed during the past decade into a directly involved business advisor, strategist, and implementer of business objectives. Intense competition has overridden previous human resources concerns and forced priorities toward internal, business-driven issues. Since cost-cutting…

How Best to Organize and Optimize the Analytical Effort Within the US Intelligence Community

DTIC Science & Technology

2010-03-19

less clear when addressing other features. Organizations such as EBay and Amazon are hybrids, while Al-Qaida offers a prime example of a...interaction amongst the many interagency tribes . Top leadership involvement would also be crucial in the implementation of the right policies and

Teacher Evaluation in the Arts Disciplines: Three State Perspectives

ERIC Educational Resources Information Center

Gates, Karol; Hansen, Deb; Tuttle, Lynn

2015-01-01

The purpose of this report is to provide insight into how state departments are implementing legislative requirements for educator evaluation, particularly the specific circumstances states encounter around arts education. Spotlights on Delaware, a first-round recipient of Race to the Top funding, and Colorado and Arizona, third-round recipients,…

Organizational Considerations for Advanced Manufacturing Technology

ERIC Educational Resources Information Center

DeRuntz, Bruce D.; Turner, Roger M.

2003-01-01

In the last several decades, the United States has experienced a decline in productivity, while the world has seen a maturation of the global marketplace. Nations have moved manufacturing strategy and process technology issues to the top of management priority lists. The issues surrounding manufacturing technologies and their implementations have…

TQM--Will It Work in Your Library?

ERIC Educational Resources Information Center

Butcher, Karyle

Scarce resources, changing customer expectation, and the changing role of top management are all factors that have contributed to the implementation of total quality management (TQM) in libraries. Instructional articles, conferences, and videos can alleviate some concerns of cost and time commitment. Many libraries already practice some of the…

Improving canopy sensor algorithms with soil and weather information

USDA-ARS?s Scientific Manuscript database

Nitrogen (N) need to support corn (Zea mays L.) production can be highly variable within fields. Canopy reflectance sensing for assessing crop N health has been implemented on many farmers’ fields to side-dress or top-dress variable-rate N application, but at times farmers report the performance of ...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Painter, J.; McCormick, P.; Krogh, M.

This paper presents the ACL (Advanced Computing Lab) Message Passing Library. It is a high throughput, low latency communications library, based on Thinking Machines Corp.`s CMMD, upon which message passing applications can be built. The library has been implemented on the Cray T3D, Thinking Machines CM-5, SGI workstations, and on top of PVM.

An International Academic Partnership through a Policy Implementation Lens: Top-Down, Bottom-Up or Somewhere in Between?

ERIC Educational Resources Information Center

Gieser, James D.

2015-01-01

Leaders of higher education institutions are eager to identify effective internationalization strategies in today's fast-paced, interconnected global environment. International academic partnerships are a common yet understudied strategy designed to take advantage of globalization's opportunities and to meet an institution's internationalization…

Improving Business-IT Alignment through Business Architecture

ERIC Educational Resources Information Center

Li, Chingmei

2010-01-01

The business and Information Technology (IT) alignment issue has become one of the Top-10 IT management issues since 1980. IT has continually strived to achieve alignment with business goals and objectives. These IT efforts include ERP implementation to benefit from the best practices; data center consolidation and server virtualization to keep…

Strategic service-line planning. Building competitive advantage.

PubMed

Greenspan, Elizabeth; Krentz, Susanna E; O'Neill, Molly K

2003-12-01

Service-line planning requires a healthcare organization to develop a business plan for each of its service lines. Successful service-line planning requires top leadership support, a willingness to allocate resources, the development of support mechanisms, the active support and involvement of physicians, and management commitment and accountability during implementation.

Evidence-Based Practice: The Psychology of EBP Implementation.

PubMed

Rousseau, Denise M; Gunia, Brian C

2016-01-01

Evidence-based practice (EBP) is an approach used in numerous professions that focuses attention on evidence quality in decision making and action. We review research on EBP implementation, identifying critical underlying psychological factors facilitating and impeding its use. In describing EBP and the forms of evidence it employs, we highlight the challenges individuals face in appraising evidence quality, particularly that of their personal experience. We next describe critical EBP competencies and the challenges underlying their acquisition: foundational competencies of critical thinking and domain knowledge, and functional competencies such as question formulation, evidence search and appraisal, and outcome evaluation. We then review research on EBP implementation across diverse fields from medicine to management and organize findings around three key contributors to EBP: practitioner ability, motivation, and opportunity to practice (AMO). Throughout, important links between psychology and EBP are highlighted, along with the contributions psychological research can make to further EBP development and implementation.

Lean practices for quality results: a case illustration.

PubMed

Hwang, Pauline; Hwang, David; Hong, Paul

2014-01-01

Increasingly, healthcare providers are implementing lean practices to achieve quality results. Implementing lean healthcare practices is unique compared to manufacturing and other service industries. The purpose of this paper is to present a model that identifies and defines the lean implementation key success factors in healthcare organisations. The model is based on an extant literature review and a case illustration that explores actual lean implementation in a major USA hospital located in a Midwestern city (approximately 300,000 people). An exploratory/descriptive study using observation and follow-up interviews was conducted to identify lean practices in the hospital. Lean practice key drivers include growing elderly populations, rising medical expenses, decreasing insurance coverage and decreasing management support. Effectively implementing lean practices to increase bottom-line results and improve organisational integrity requires sharing goals and processes among healthcare managers and professionals. An illustration explains the model and the study provides a sound foundation for empirical work. Practical implications are included. Lean practices minimise waste and unnecessary hospital stays while simultaneously enhancing customer values and deploying resources in supply systems. Leadership requires clear project targets based on sound front-end planning because initial implementation steps involve uncertainty and ambiguity (i.e. fuzzy front-end planning). Since top management support is crucial for implementing lean practices successfully, a heavyweight manager, who communicates well both with top managers and project team members, is an important success factor when implementing lean practices. Increasingly, green orientation and sustainability initiatives are phrases that replaced lean practices. Effective results; e.g. waste reduction, employee satisfaction and customer values are applicable to bigger competitive challenges arising both in specific organisations and inter-organisational networks. Healthcare managers are adopting business practices that improve efficiency and productivity while ensuring their healthcare mission and guaranteeing that customer values are achieved. Shared understanding about complex goals (e.g. reducing waste and enhancing customer value) at the front-end is crucial for implementing successful lean practices. In particular, this study shows that nursing practices, which are both labour intensive and technology enabled, are good candidates for lean practice.

Top-down proteomics reveals a unique protein S-thiolation switch in Salmonella Typimurium in response to infection-like conditions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ansong, Charles; Wu, Si; Meng, Da

Characterization of the mature protein complement in cells is crucial for a better understanding of cellular processes on a systems-wide scale. Bottom-up proteomic approaches often lead to loss of critical information about an endogenous protein’s actual state due to post translational modifications (PTMs) and other processes. Top-down approaches that involve analysis of the intact protein can address this concern but present significant analytical challenges related to the separation quality needed, measurement sensitivity, and speed that result in low throughput and limited coverage. Here we used single-dimension ultra high pressure liquid chromatography mass spectrometry to investigate the comprehensive ‘intact’ proteome ofmore » the Gram negative bacterial pathogen Salmonella Typhimurium. Top-down proteomics analysis revealed 563 unique proteins including 1665 proteoforms generated by PTMs, representing the largest microbial top-down dataset reported to date. Our analysis not only confirmed several previously recognized aspects of Salmonella biology and bacterial PTMs in general, but also revealed several novel biological insights. Of particular interest was differential utilization of the protein S-thiolation forms S-glutathionylation and S-cysteinylation in response to infection-like conditions versus basal conditions, which was corroborated by changes in corresponding biosynthetic pathways. This differential utilization highlights underlying metabolic mechanisms that modulate changes in cellular signaling, and represents to our knowledge the first report of S-cysteinylation in Gram negative bacteria. The demonstrated utility of our simple proteome-wide intact protein level measurement strategy for gaining biological insight should promote broader adoption and applications of top-down proteomics approaches.« less

Citation classics in nursing journals: the top 50 most frequently cited articles from 1956 to 2011.

PubMed

Wong, Eliza L Y; Tam, Wilson W S; Wong, Faye C Y; Cheung, Annie W L

2013-01-01

Assessing the impact of individual journal articles provides information for understanding trends in science and translation of findings on practice. Citation analysis is an important way to highlight the contributions of individual author/investigator and journals on nursing practice. The purpose of this study was to identify the most frequently cited articles published in nursing journals from 1956 to 2011. The Science Citation Index Expanded and Social Sciences Citation Index were searched for citations through 2011 to articles published in the 89 nursing journals listed on the Journal Citation Reports (2010 edition). The number of citations, topic, countries, and institutions of origin based on the first author affiliation, year of publication, study design, publishing journal, journal country, and journal impact factor were noted. The most frequently cited articles published in the 89 nursing journals from 1956 to 2011 were identified. The top 50 most frequently cited articles were published in 10 nursing journals between 1970 and 2005. The top cited article received 784 citations. The most common topics were methodology for qualitative studies, validation procedures for tool development, and nursing care and practices in cancer and mental health. The most common study designs were reviews including meta-analysis and instrument validation. Most of the top 50 cited articles were published from 1986 to 1995. The findings provide insights into priorities and trends in nursing research and translational science.

Are We There Yet? Human Factors Knowledge and Health Information Technology - the Challenges of Implementation and Impact.

PubMed

Turner, P; Kushniruk, A; Nohr, C

2017-08-01

Objective: To review the developments in human factors (HF) research on the challenges of health information technology (HIT) implementation and impact given the continuing incidence of usability problems and unintended consequences from HIT development and use. Methods: A search of PubMed/Medline and Web of Science® identified HF research published in 2015 and 2016. Electronic health records (EHRs) and patient-centred HIT emerged as significant foci of recent HF research. The authors selected prominent papers highlighting ongoing HF and usability challenges in these areas. This selective rather than systematic review of recent HF research highlights these key challenges and reflects on their implications on the future impact of HF research on HIT. Results: Research provides evidence of continued poor design, implementation, and usability of HIT, as well as technology-induced errors and unintended consequences. The paper highlights support for: (i) strengthening the evidence base on the benefits of HF approaches; (ii) improving knowledge translation in the implementation of HF approaches during HIT design, implementation, and evaluation; (iii) increasing transparency, governance, and enforcement of HF best practices at all stages of the HIT system development life cycle. Discussion and Conclusion: HF and usability approaches are yet to become embedded as integral components of HIT development, implementation, and impact assessment. As HIT becomes ever-more pervasive including with patients as end-users, there is a need to expand our conceptualisation of the problems to be addressed and the suite of tactics and strategies to be used to calibrate our pro-active involvement in its improvement. Georg Thieme Verlag KG Stuttgart.

Simplified models for Higgs physics: singlet scalar and vector-like quark phenomenology

DOE PAGES

Dolan, Matthew J.; Hewett, J. L.; Krämer, M.; ...

2016-07-08

Simplified models provide a useful tool to conduct the search and exploration of physics beyond the Standard Model in a model-independent fashion. In this study, we consider the complementarity of indirect searches for new physics in Higgs couplings and distributions with direct searches for new particles, using a simplified model which includes a new singlet scalar resonance and vector-like fermions that can mix with the SM top-quark. We fit this model to the combined ATLAS and CMS 125 GeV Higgs production and coupling measurements and other precision electroweak constraints, and explore in detail the effects of the new matter contentmore » upon Higgs production and kinematics. Finally, we highlight some novel features and decay modes of the top partner phenomenology, and discuss prospects for Run II.« less

Java, Indonesia

NASA Image and Video Library

1996-01-20

STS072-737-012 (11-20 Jan. 1996) --- The astronauts photographed this view of Java, an Indonesian island. Java lies between the Java Sea at top and the Indian Ocean at bottom (north is located at top center). A line of volcanoes on the southern edge of the island, trending from central to eastern areas, is highlighted by a ring of clouds. Off the southern coast of Java is the Java Trench where the Australian plate, to the south, is diving under the Eurasia plate to the north. According to anthropologists, Java has one of the highest populations in Indonesia because the soil is enriched by volcanic ash. Merapi volcano, at left edge, second volcano to the right, rises to 9,550 feet and erupts frequently. Madura Island, partially obscured by clouds, can be seen on the upper eastern end of Java.

Detecting, reporting, and analysis of priority diseases for routine public health surveillance in Liberia.

PubMed

Frimpong, Joseph Asamoah; Park, Meeyoung Mattie; Amo-Addae, Maame Pokuah; Adewuyi, Peter Adebayo; Nagbe, Thomas Knue

2017-01-01

An essential component of a public health surveillance system is its ability to detect priority diseases which fall within the mandate of public health officials at all levels. Early detection, reporting and response to public health events help to reduce the burden of mortality and morbidity on communities. Analysis of reliable surveillance data provides relevant information which can enable implementation of timely and appropriate public health interventions. To ensure that a resilient system is in place, the World Health Organization (WHO) has provided guidelines for detection, reporting and response to public health events in the Integrated Disease Surveillance and Response (IDSR) strategy. This case study provides training on detection, reporting and analysis of priority diseases for routine public health surveillance in Liberia and highlights potential errors and challenges which can hinder effective surveillance. Table-top exercises and group discussion lead participants through a simulated verification and analyses of summary case reports in the role of the District Surveillance Officer. This case study is intended for public health training in a classroom setting and can be accomplished within 2 hours 30 minutes. The target audience include residents in Frontline Epidemiology Training Programs (FETP-Frontline), Field Epidemiology and Laboratory Training Programs (FELTPs), and others who are interested in this topic.

Indoor air quality scenario in India-An outline of household fuel combustion

NASA Astrophysics Data System (ADS)

Rohra, Himanshi; Taneja, Ajay

2016-03-01

Most of the research around the world has been on outdoor air pollution, but in India we have a more severe problem of Indoor Air Pollution (IAP). The foremost factor cited for is burning of fossil fuels for cooking. Among the 70% of the country's rural population, about 80% households rely on biomass fuel making India to top the list of countries with largest population lacking access to cleaner fuel for cooking. 4 million deaths and 5% disability-adjusted life-years is an upshot of exposure to IAP from unhealthy cooking making it globally the most critical environmental risk factor. India alone bears the highest burden (28% needless deaths) among developing countries. Moreover, about ¼ of ambient PM2.5 in the country comes from household cookfuels. These considerations have prompted the discussion of the present knowledge on the disastrous health effects of pollutants emitted by biomass combustion in India. Additionally, Particulate Matter as an indoor air pollutant is highlighted with main focus on its spatial temporal variation and some recent Indian studies are further explored. As there are no specific norms for IAP in India, urgent need has arisen for implementing the strategies to create public awareness. Moreover improvement in ventilation and modification in the pattern of fuel will also contribute to eradicate this national health issue.

LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures.

PubMed

Duan, Qiaonan; Flynn, Corey; Niepel, Mario; Hafner, Marc; Muhlich, Jeremy L; Fernandez, Nicolas F; Rouillard, Andrew D; Tan, Christopher M; Chen, Edward Y; Golub, Todd R; Sorger, Peter K; Subramanian, Aravind; Ma'ayan, Avi

2014-07-01

For the Library of Integrated Network-based Cellular Signatures (LINCS) project many gene expression signatures using the L1000 technology have been produced. The L1000 technology is a cost-effective method to profile gene expression in large scale. LINCS Canvas Browser (LCB) is an interactive HTML5 web-based software application that facilitates querying, browsing and interrogating many of the currently available LINCS L1000 data. LCB implements two compacted layered canvases, one to visualize clustered L1000 expression data, and the other to display enrichment analysis results using 30 different gene set libraries. Clicking on an experimental condition highlights gene-sets enriched for the differentially expressed genes from the selected experiment. A search interface allows users to input gene lists and query them against over 100 000 conditions to find the top matching experiments. The tool integrates many resources for an unprecedented potential for new discoveries in systems biology and systems pharmacology. The LCB application is available at http://www.maayanlab.net/LINCS/LCB. Customized versions will be made part of the http://lincscloud.org and http://lincs.hms.harvard.edu websites. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

[Implementing strategies to improve the institutional governance of the Spanish National Health System].

PubMed

Repullo, José Ramón; Freire, José Manuel

2016-11-01

The 2008 economic crisis made the issue of good governance more present and visible, but the debate risks stalling in an academic and political discourse that barely exceeds the declarative. We acknowledge the existence of noteworthy documents from scientific medical societies and some institutional proposals that point towards promising changes. Viewing good governance as accountability, participation, transparency, intelligence and integrity, our objective is to identify the determinants of inaction and remove the barriers that prevent the adoption of rational and widely agreed-upon proposals. This led us: 1) to allocate the proposals to their appropriate governance level (macro, meso, micro and system environment) so as to more directly engage the agents of change; and 2) to highlight some decision nodes that can act as levers to catalyse selective transformations and to initiate the change processes. Taking into account the diversity of actors and scenarios, a top-down rational, integrated and reformist strategy for the whole Spanish National Health System does not seem likely or viable. Therefore, the purpose of this paper is to promote changes, setting a targeted and reasoned agenda to visualise key issues and to enable multilevel and multidimensional thinking and advocacy of health-sector and society stakeholders. Copyright © 2016 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

V L Ginzburg and the Atomic Project

NASA Astrophysics Data System (ADS)

Ritus, V. I.

2017-04-01

This paper is an expanded version of the author's talk presented at a session of the Physical Sciences Division of the Russian Academy of Sciences celebrating the 100th anniversary of V L Ginzburg's birth. Tamm's Special group was organized in June 1948 with the task to clarify the feasibility of constructing a hydrogen bomb. Having verified and confirmed the calculated results by Ya B Zel'dovich's group, the Tamm group proposed an original hydrogen bomb design, which, following A D Sakharov's idea, consisted of an atomic bomb surrounded spherically by nested uranium and heavy water layers: the heavy water, on V L Ginzburg's suggestion, was replaced by higher-calorie solid lithium-6 deuteride. The ionization implosion of deuterium by uranium, both heated by the atomic bomb's explosion, greatly accelerates nuclear reactions in deuterium and uranium and increases the total energy release. Upon their approval by the KB-11 top researchers, the Atomic project leadership, and the government, the proposals were implemented in the RDS-6s bomb, which was successfully tested on 12 August 1953. Lithium-6 deuteride turned out to be a convenient multipurpose nuclear fuel. The paper highlights the recognition by the leaders of the country and of the Atomic project that fundamental science plays a crucial role in promoting scientists' ideas and proposals.

Energy Efficiency of the Outotec® Ausmelt Process for Primary Copper Smelting

NASA Astrophysics Data System (ADS)

Wood, Jacob; Hoang, Joey; Hughes, Stephen

2017-03-01

The global, non-ferrous smelting industry has witnessed the continual development and evolution of processing technologies in a bid to reduce operating costs and improve the safety and environmental performance of processing plants. This is particularly true in the copper industry, which has seen a number of bath smelting technologies developed and implemented during the past 30 years. The Outotec® Ausmelt Top Submerged Lance Process is one such example, which has been widely adopted in the modernisation of copper processing facilities in China and Russia. Despite improvements in the energy efficiency of modern copper smelting and converting technologies, additional innovation and development is required to further reduce energy consumption, whilst still complying with stringent environmental regulations. In response to this challenge, the Ausmelt Process has undergone significant change and improvement over the course of its history, in an effort to improve its overall competitiveness, particularly with respect to energy efficiency and operating costs. This paper covers a number of recent advances to the technology and highlights the impacts of these developments in reducing energy consumptions for a range of different copper flowsheets. It also compares the energy efficiency of the Ausmelt Process against the Bottom Blown Smelting process, which has become widely adopted in China over the past 5-10 years.

Environmental Health: Opportunities for Greater Focus, Direction, and Top-Level Commitment to Children's Health at EPA. Testimony Before the Committee on Environment and Public Works, U.S. Senate. GAO-10-545T

ERIC Educational Resources Information Center

Stephenson, John B.

2010-01-01

This testimony discusses highlights of GAO's report about the Environmental Protection Agency's (EPA) efforts to institutionalize the protection of children's health. EPA's mission is to protect human health and the environment. As a result of mounting evidence about the special vulnerabilities of the developing fetus and child, the federal…

Decade of War, Volume 1. Enduring Lessons from the Past Decade of Operations

DTIC Science & Technology

2012-06-15

the incident took on political dimensions or was highlighted in the international news media .14 Conventional war features a hierarchical top-down...half of the decade. The proliferation of the internet, social media , and personal electronic devices caused the paradigm of communication to shift...unconstrained by the truth: for example, they could feed false information to the media through the use of news stringers on fast-dial from an

Lightcurve Photometry Opportunities: 2009 October-December

NASA Astrophysics Data System (ADS)

Warner, Brian D.; Harris, Alan W.; Pravec, Petr; Durech, Josef; Benner, Lance A. M.

2010-01-01

With a New Year come new things. For this regular article it means an “In Focus” section at the top that highlights particular topics or calls extra attention to listed targets so that they don’t get overlooked. We have trimmed the material in the standard text, keeping the essential elements and Internet web sites. For more background on the program details for each list, refer to previous issues, e.g., Minor Planet Bulletin 36, 188.

A high gain antenna system for airborne satellite communication applications

NASA Technical Reports Server (NTRS)

Maritan, M.; Borgford, M.

1990-01-01

A high gain antenna for commercial aviation satellites communication is discussed. Electromagnetic and practical design considerations as well as candidate systems implementation are presented. An evaluation of these implementation schemes is given, resulting in the selection of a simple top mounted aerodynamic phased array antenna with a remotely located beam steering unit. This concept has been developed into a popular product known as the Canadian Marconi Company CMA-2100. A description of the technical details is followed by a summary of results from the first production antennas.

Segregating Top-Down Selective Attention from Response Inhibition in a Spatial Cueing Go/NoGo Task: An ERP and Source Localization Study.

PubMed

Hong, Xiangfei; Wang, Yao; Sun, Junfeng; Li, Chunbo; Tong, Shanbao

2017-08-29

Successfully inhibiting a prepotent response tendency requires the attentional detection of signals which cue response cancellation. Although neuroimaging studies have identified important roles of stimulus-driven processing in the attentional detection, the effects of top-down control were scarcely investigated. In this study, scalp EEG was recorded from thirty-two participants during a modified Go/NoGo task, in which a spatial-cueing approach was implemented to manipulate top-down selective attention. We observed classical event-related potential components, including N2 and P3, in the attended condition of response inhibition. While in the ignored condition of response inhibition, a smaller P3 was observed and N2 was absent. The correlation between P3 and CNV during the foreperiod suggested an inhibitory role of P3 in both conditions. Furthermore, source analysis suggested that P3 generation was mainly localized to the midcingulate cortex, and the attended condition showed increased activation relative to the ignored condition in several regions, including inferior frontal gyrus, middle frontal gyrus, precentral gyrus, insula and uncus, suggesting that these regions were involved in top-down attentional control rather than inhibitory processing. Taken together, by segregating electrophysiological correlates of top-down selective attention from those of response inhibition, our findings provide new insights in understanding the neural mechanisms of response inhibition.

Top-down control of visual perception: attention in natural vision.

PubMed

Rolls, Edmund T

2008-01-01

Top-down perceptual influences can bias (or pre-empt) perception. In natural scenes, the receptive fields of neurons in the inferior temporal visual cortex (IT) shrink to become close to the size of objects. This facilitates the read-out of information from the ventral visual system, because the information is primarily about the object at the fovea. Top-down attentional influences are much less evident in natural scenes than when objects are shown against blank backgrounds, though are still present. It is suggested that the reduced receptive-field size in natural scenes, and the effects of top-down attention contribute to change blindness. The receptive fields of IT neurons in complex scenes, though including the fovea, are frequently asymmetric around the fovea, and it is proposed that this is the solution the IT uses to represent multiple objects and their relative spatial positions in a scene. Networks that implement probabilistic decision-making are described, and it is suggested that, when in perceptual systems they take decisions (or 'test hypotheses'), they influence lower-level networks to bias visual perception. Finally, it is shown that similar processes extend to systems involved in the processing of emotion-provoking sensory stimuli, in that word-level cognitive states provide top-down biasing that reaches as far down as the orbitofrontal cortex, where, at the first stage of affective representations, olfactory, taste, flavour, and touch processing is biased (or pre-empted) in humans.

Top-up operation at Pohang Light Source-II

NASA Astrophysics Data System (ADS)

Hwang, I.; Huang, J. Y.; Kim, M.; Lee, B.-J.; Kim, C.; Choi, J.-Y.; Kim, M.-H.; Lee, H. S.; Moon, D.; Lee, E. H.; Kim, D.-E.; Nam, S. H.; Shin, S.; Cho, Moohyun

2014-05-01

After three years of upgrading work, PLS-II (S. Shin, Commissioning of the PLS-II, JINST, January 2013) is now successfully operating. The top-up operation of the 3 GeV linear accelerator had to be delayed because of some challenges encountered, and PLS-II was run in decay mode at the beginning in March 2012. The main difficulties encountered in the top-up operation of PLS-II are different levels between the linear accelerator and the storage ring, the 14 narrow gap in-vacuum undulators in operation, and the full energy injection by 3 GeV linear accelerator. Large vertical emittance and energy jitter of the linac were the major obstacles that called for careful control of injected beam to reduce beam loss in the storage ring during injection. The following measures were taken to resolve these problems: (1) The high resolution Libera BPM (see http://www.i-tech.si) was implemented to measure the beam trajectory and energy. (2) Three slit systems were installed to filter the beam edge. (3) De-Qing circuit was applied to the modulator system to improve the energy stability of injected beam. As a result, the radiation by beam loss during injection is reduced drastically, and the top-up mode has been successfully operating since 19th March 2013. In this paper, we describe the experimental results of the PLS-II top-up operation and the improvement plan.

Extreme load alleviation using industrial implementation of active trailing edge flaps in a full design load basis

NASA Astrophysics Data System (ADS)

Barlas, Thanasis; Pettas, Vasilis; Gertz, Drew; Madsen, Helge A.

2016-09-01

The application of active trailing edge flaps in an industrial oriented implementation is evaluated in terms of capability of alleviating design extreme loads. A flap system with basic control functionality is implemented and tested in a realistic full Design Load Basis (DLB) for the DTU 10MW Reference Wind Turbine (RWT) model and for an upscaled rotor version in DTU's aeroelastic code HAWC2. The flap system implementation shows considerable potential in reducing extreme loads in components of interest including the blades, main bearing and tower top, with no influence on fatigue loads and power performance. In addition, an individual flap controller for fatigue load reduction in above rated power conditions is also implemented and integrated in the general controller architecture. The system is shown to be a technology enabler for rotor upscaling, by combining extreme and fatigue load reduction.

Flight elements: Fault detection and fault management

NASA Technical Reports Server (NTRS)

Lum, H.; Patterson-Hine, A.; Edge, J. T.; Lawler, D.

1990-01-01

Fault management for an intelligent computational system must be developed using a top down integrated engineering approach. An approach proposed includes integrating the overall environment involving sensors and their associated data; design knowledge capture; operations; fault detection, identification, and reconfiguration; testability; causal models including digraph matrix analysis; and overall performance impacts on the hardware and software architecture. Implementation of the concept to achieve a real time intelligent fault detection and management system will be accomplished via the implementation of several objectives, which are: Development of fault tolerant/FDIR requirement and specification from a systems level which will carry through from conceptual design through implementation and mission operations; Implementation of monitoring, diagnosis, and reconfiguration at all system levels providing fault isolation and system integration; Optimize system operations to manage degraded system performance through system integration; and Lower development and operations costs through the implementation of an intelligent real time fault detection and fault management system and an information management system.

Implementing Computer-Based Training for Library Staff.

ERIC Educational Resources Information Center

Bayne, Pauline S.; And Others

1994-01-01

Describes a computer-based training program for library staff developed at the University of Tennessee, Knoxville, that used HyperCard stacks on Macintosh computers. Highlights include staff involvement; evaluation of modules; trainee participation and feedback; staff recognition; administrative support; implementation plan; supervisory…

Pharmacy-based statewide naloxone distribution: A novel "top-down, bottom-up" approach.

PubMed

Morton, Kate J; Harrand, Brianna; Floyd, Carly Cloud; Schaefer, Craig; Acosta, Julie; Logan, Bridget Claire; Clark, Karen

To highlight New Mexico's multifaceted approach to widespread pharmacy naloxone distribution and to share the interventions as a tool for improving pharmacy-based naloxone practices in other states. New Mexico had the second highest drug overdose death rate in 2014 of which 53% were related to prescription opioids. Opioid overdose death is preventable through the use of naloxone, a safe and effective medication that reverses the effects of prescription opioids and heroin. Pharmacists can play an important role in providing naloxone to individuals who use prescription opioids. Not applicable. Not applicable. A multifaceted approach was utilized in New Mexico from the top down with legislative passage of provisions for a statewide standing order and New Mexico Department of Health support for pharmacy-based naloxone delivery. A bottom up approach was also initiated with the development and implementation of a training program for pharmacists and pharmacy technicians. Naloxone Medicaid claims were used to illustrate statewide distribution and utilization of the pharmacist statewide standing order for naloxone. Percent of pharmacies dispensing naloxone in each county were calculated. Trained pharmacy staff completed a program evaluation form. Questions about quality of instruction and ability of trainer to meet stated objectives were rated on a Likert scale. There were 808 naloxone Medicaid claims from 100 outpatient pharmacies during the first half of 2016, a 9-fold increase over 2014. The "A Dose of R x eality" training program evaluation indicated that participants felt the training was free from bias and met all stated objectives (4 out of 4 on Likert scale). A multi-pronged approach coupling state and community collaboration was successful in overcoming barriers and challenges associated with pharmacy naloxone distribution and ensured its success as an effective avenue for naloxone acquisition in urban and rural communities. Copyright © 2017 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Bench-top endomicroscope for visualization and imaging of nuclei using ultraviolet autofluorescence

NASA Astrophysics Data System (ADS)

Lin, Bevin

The long range goal of this research was to develop autofluorescence technology and instrumentation for transition towards an in vivo endomicroscopy imaging system. This approach would provide resolution sufficient to image nuclei for real-time categorization of normal and abnormal tissue implicative of disease progression. Esophageal adenocarcinoma was the chosen model to develop this diagnostic imaging system because the heterogeneous and multifocal nature of this disease makes early diagnosis extremely challenging during the window of time when the prognosis for survival is high. The asymptomatic character of this disease generally presents at a malignant stage when removal of the esophagus has become the standard treatment. The traditional gold standard of histologic diagnosis suffers from a slow turn-around-time from tissue removal to microscopic observation, compounded by error in random biopsy sampling and tissue-processing artifacts, in addition to significant variation in pathologist diagnosis. Optical biopsy has thus been developed to alleviate the problems associated with current standard video endoscopy and histopathology. Following tremendous research in the realm of optical biopsy, some traction has been gained using confocal endomicroscopy. However, current confocal methods require contrast agents and optical sectioning in order to provide images at a cellular level. We have developed a minimally invasive imaging system using autofluorescence that highlights the short photon penetration depth of ultraviolet excitation. This approach provides cellular level resolution with a clinically relevant field of view without requiring contrast agents or optical sectioning. Optical histopathology has been demonstrated using unprocessed ex vivo human gastrointestinal tissues providing diagnostic assessment in real-time, a function imperative for improved patient care and quality of life. This robust bench-top prototype endomicroscopy system is capable of rapid throughput, high sensitivity and specificity, provides a user friendly interface, and preserves distinct advantages in cost based on instrumentation simplicity. These advantages poise this ultraviolet autofluorescence endomicroscopy system for break-through clinical implementation.

Taking Action on Air Pollution Control in the Beijing-Tianjin-Hebei (BTH) Region: Progress, Challenges and Opportunities

PubMed Central

Wang, Li; Zhang, Fengying; Pilot, Eva; Yu, Jie; Holdaway, Jennifer; Yang, Linsheng; Li, Yonghua; Wang, Wuyi; Vardoulakis, Sotiris; Krafft, Thomas

2018-01-01

Due to rapid urbanization, industrialization and motorization, a large number of Chinese cities are affected by heavy air pollution. In order to explore progress, remaining challenges, and sustainability of air pollution control in the Beijing-Tianjin-Hebei (BTH) region after 2013, a mixed method analysis was undertaken. The quantitative analysis comprised an overview of air quality management in the BTH region. Semi-structured expert interviews were conducted with 12 stakeholders from various levels of government and research institutions who played substantial roles either in decision-making or in research and advising on air pollution control in the BTH region. The results indicated that with the stringent air pollution control policies, the air quality in BTH meets the targets of the Air Pollution Prevention and Control Action Plan. However, improvements vary across the region and for different pollutants. Although implementation has been decisive and was at least in parts effectively enforced, significant challenges remained with regard to industrial and traffic emission control, and national air quality limits continued to be significantly exceeded and competing development interests remained mainly unsolved. There were also concerns about the sustainability of the current air pollution control measures especially for industries due to the top-down enforcement, and the associated large burden of social cost including unemployment and social inequity resulting industrial restructuring. Better mechanisms for ensuring cross-sectoral coordination and for improved central-local government communication were suggested. Further suggestions were provided to improve the conceptual design and effective implementation of respective air pollution control strategies in BTH. Our study highlights some of the major hurdles that need to be addressed to succeed with a comprehensive air pollution control management for the Chinese mega-urban agglomerations. PMID:29425189

Taking Action on Air Pollution Control in the Beijing-Tianjin-Hebei (BTH) Region: Progress, Challenges and Opportunities.

PubMed

Wang, Li; Zhang, Fengying; Pilot, Eva; Yu, Jie; Nie, Chengjing; Holdaway, Jennifer; Yang, Linsheng; Li, Yonghua; Wang, Wuyi; Vardoulakis, Sotiris; Krafft, Thomas

2018-02-09

Due to rapid urbanization, industrialization and motorization, a large number of Chinese cities are affected by heavy air pollution. In order to explore progress, remaining challenges, and sustainability of air pollution control in the Beijing-Tianjin-Hebei (BTH) region after 2013, a mixed method analysis was undertaken. The quantitative analysis comprised an overview of air quality management in the BTH region. Semi-structured expert interviews were conducted with 12 stakeholders from various levels of government and research institutions who played substantial roles either in decision-making or in research and advising on air pollution control in the BTH region. The results indicated that with the stringent air pollution control policies, the air quality in BTH meets the targets of the Air Pollution Prevention and Control Action Plan. However, improvements vary across the region and for different pollutants. Although implementation has been decisive and was at least in parts effectively enforced, significant challenges remained with regard to industrial and traffic emission control, and national air quality limits continued to be significantly exceeded and competing development interests remained mainly unsolved. There were also concerns about the sustainability of the current air pollution control measures especially for industries due to the top-down enforcement, and the associated large burden of social cost including unemployment and social inequity resulting industrial restructuring. Better mechanisms for ensuring cross-sectoral coordination and for improved central-local government communication were suggested. Further suggestions were provided to improve the conceptual design and effective implementation of respective air pollution control strategies in BTH. Our study highlights some of the major hurdles that need to be addressed to succeed with a comprehensive air pollution control management for the Chinese mega-urban agglomerations.

Multiformat decoder for a DSP-based IP set-top box

NASA Astrophysics Data System (ADS)

Pescador, F.; Garrido, M. J.; Sanz, C.; Juárez, E.; Samper, D.; Antoniello, R.

2007-05-01

Internet Protocol Set-Top Boxes (IP STBs) based on single-processor architectures have been recently introduced in the market. In this paper, the implementation of an MPEG-4 SP/ASP video decoder for a multi-format IP STB based on a TMS320DM641 DSP is presented. An initial decoder for PC platform was fully tested and ported to the DSP. Using this code an optimization process was started achieving a 90% speedup. This process allows real-time MPEG-4 SP/ASP decoding. The MPEG-4 decoder has been integrated in an IP STB and tested in a real environment using DVD movies and TV channels with excellent results.

A Generic Mesh Data Structure with Parallel Applications

ERIC Educational Resources Information Center

Cochran, William Kenneth, Jr.

2009-01-01

High performance, massively-parallel multi-physics simulations are built on efficient mesh data structures. Most data structures are designed from the bottom up, focusing on the implementation of linear algebra routines. In this thesis, we explore a top-down approach to design, evaluating the various needs of many aspects of simulation, not just…

78 FR 53991 - Applications for New Awards; Race to the Top-Early Learning Challenge

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-30

... gaps for Children with High Needs.\\1\\ This program focuses on improving early learning and development... disadvantaged children in each age group of infants, toddlers, and preschoolers who are enrolled in high-quality... implement an integrated system of high-quality Early Learning and Development Programs and services. \\1...

Literacy at the Core of the Delaware World Language Immersion Programs

ERIC Educational Resources Information Center

Fulton-Archer, Lynn

2013-01-01

Certain aspects of the implementation of language immersion programs in Delaware are unique given the state's size, demographics, and role in national education initiatives including Race to the Top, Common Core, and Smarter Balance. The Delaware experience typifies what every state, district, or even school goes through as they try to provide…

Algorithm Visualization System for Teaching Spatial Data Algorithms

ERIC Educational Resources Information Center

Nikander, Jussi; Helminen, Juha; Korhonen, Ari

2010-01-01

TRAKLA2 is a web-based learning environment for data structures and algorithms. The system delivers automatically assessed algorithm simulation exercises that are solved using a graphical user interface. In this work, we introduce a novel learning environment for spatial data algorithms, SDA-TRAKLA2, which has been implemented on top of the…

75 FR 19495 - Overview Information; Race to the Top Fund; Notice Inviting Applications for New Awards for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-14

... graduation rates, and ensuring student preparation for success in college and careers; and implementing... assessments that prepare students for success in college and the workplace; (b) Building data systems that... rates at which students graduate from high school prepared for college and careers. Competitive...

Absorptive Capacity in Rural Schools: Bending Not Breaking during Disruptive Innovation Implementation

ERIC Educational Resources Information Center

Zuckerman, Sarah J.; Wicox, Kristen Campbell; Schiller, Kathryn S.; Durand, Francesca T.

2018-01-01

Rural schools have repeatedly been subjected to standardizing state and federal education policies that seek to minimize variance in instructional systems and increase the number of college- and career-ready graduates. The Race to the Top policy agenda combined standards-based and accountability-based reforms to meet these objectives and once…

3 CFR 13534 - Executive Order 13534 of March 11, 2010. National Export Initiative

Code of Federal Regulations, 2011 CFR

2011-01-01

... sustainable economic growth is the top priority for my Administration. A critical component of stimulating economic growth in the United States is ensuring that U.S. businesses can actively participate in... established an Export Promotion Cabinet to develop and coordinate the implementation of the NEI. The Export...

Factors Influencing EFL Novice Teachers' Adoption of Technologies in Classroom Practice

ERIC Educational Resources Information Center

Dinh, Huong Thi Bao

2009-01-01

A primary research conducted with 12 Vietnamese teachers of English using questionnaires and semi-structured interviews has revealed that big investment into technological infrastructure and the top-down approach of implementing technological change in English teaching are not a guarantee for the adoption of technology by English teachers in their…

Process Improvement Teams: A TQM Strategy for Improving Community College Systems.

ERIC Educational Resources Information Center

Needham, Robbie Lee; And Others

The three principle elements of Total Quality Management (TQM) are a focus on customers; an attitude of continuous improvement of a system; and the involvement of everyone within an organization. At Delaware County Community College (DCCC) in Media, Pennsylvania, the first phase of implementing TQM focused on educating top management for the…

Amalgamation, Expansion, Quality Assurance and Innovations: A Case Study on a Key University in China

ERIC Educational Resources Information Center

Zhang, Jingning

2010-01-01

The Chinese higher education reform policies since 1993 have been pursued in a centralized, top-down manner, which some theorists characterize as "centralized decentralization" or governmental "steering at distance." This case-study dissertation has two purposes. First, is to evaluate the implementation or the "situated…

Enhancing Deep Learning: Lessons from the Introduction of Learning Teams in Management Education in France

ERIC Educational Resources Information Center

Borredon, Liz; Deffayet, Sylvie; Baker, Ann C.; Kolb, David

2011-01-01

Drawing from the reflective teaching and learning practices recommended in influential publications on learning styles, experiential learning, deep learning, and dialogue, the authors tested the concept of "learning teams" in the framework of a leadership program implemented for the first time in a top French management school…

The Design and Implementation of INGRES.

ERIC Educational Resources Information Center

Stonebraker, Michael; And Others

The currently operational version of the INGRES data base management system gives a relational view of data, supports two high level, non-procedural data sublanguages, and runs as a collection of user processes on top of a UNIX operating system. The authors stress the design decisions and tradeoffs in relation to (1) structuring the system into…

The Impact of Performance Ratings on Job Satisfaction for Public School Teachers

ERIC Educational Resources Information Center

Koedel, Cory; Li, Jiaxi; Springer, Matthew G.; Tan, Li

2017-01-01

Spurred by the federal Race to the Top competition, the state of Tennessee implemented a comprehensive statewide educator evaluation system in 2011. The new system is designed to increase the rigor of evaluations and better differentiate teachers based on performance. The use of more differentiated ratings represents a significant shift in…

Critical Teacher Education and the Politics of Teacher Accreditation: Are We Practicing What We Preach?

ERIC Educational Resources Information Center

Aronson, Brittany; Anderson, Ashlee

2013-01-01

With this article, we challenge the successful implementation of critical perspectives in an increasingly neoliberal and neoconservative educational climate. Although many teacher education programs challenge teachers to be critical and to empower students, current top-down accountability practices and policy mandates do not allow teachers the…

77 FR 29429 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing of Proposed Rule Change Relating...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-17

... investment objective by implementing a ``top-down'' portfolio management style. This management style begins...'' portfolio management style utilizes a tactical and globally diversified allocation strategy in an attempt to... open-end management investment company.\\5\\ The investment adviser to the Fund is AdvisorShares...

The Relationship Factor: Making or Breaking Successful Transitions for Youth at Risk

ERIC Educational Resources Information Center

Powell, Norman W.; Marshall, Amy

2011-01-01

Whenever educators are asked to identify the major problems they face, behavior management is near the top of the list. Research shows that effective teachers are able to build relationships with students and implement well-developed classroom procedures (Holt, Hargrove, & Harris, 2011, p. 18). Yet schools give scant attention to developing…

LMS Lessons

ERIC Educational Resources Information Center

Freifeld, Lorri

2010-01-01

With technology changing every second of every day, it is no surprise a learning management system (LMS) quickly can become outdated. But it is no easy task to re-engineer a current LMS or find exactly the right new one to purchase. In this article, three 2010 Top Young Trainers share their experiences with implementing or re-engineering an…

Intentional Teaching with Technology

ERIC Educational Resources Information Center

Mooney, Eileen B.

2018-01-01

Top-down implementation of technology is one of the most pervasive phenomena of the last couple of decades in educational history. It is the subject of many books, articles, and blog posts on how to fix schools or why educational technology is not working in the classroom. The idea of providing teachers with technology so they can make students…

Exploring Possible Links between Professional Learning Communities and Complex Adaptive Systems

ERIC Educational Resources Information Center

Johnson, Eric

2013-01-01

Implementation of Professional Learning Communities (PLC), as described by DuFour (2006), has depended upon a balance between teacher buy-in and administrative fiat. The tension between the "bottom-up" character of the former and the "top-down" character of the latter presents a leadership challenge: meeting students' learning…

A Framework for Enhancing the Value of Research for Dissemination and Implementation

PubMed Central

Glasgow, Russell E.; Carpenter, Christopher R.; Grimshaw, Jeremy M.; Rabin, Borsika A.; Fernandez, Maria E.; Brownson, Ross C.

2015-01-01

A comprehensive guide that identifies critical evaluation and reporting elements necessary to move research into practice is needed. We propose a framework that highlights the domains required to enhance the value of dissemination and implementation research for end users. We emphasize the importance of transparent reporting on the planning phase of research in addition to delivery, evaluation, and long-term outcomes. We highlight key topics for which well-established reporting and assessment tools are underused (e.g., cost of intervention, implementation strategy, adoption) and where such tools are inadequate or lacking (e.g., context, sustainability, evolution) within the context of existing reporting guidelines. Consistent evaluation of and reporting on these issues with standardized approaches would enhance the value of research for practitioners and decision-makers. PMID:25393182

Achievements and perspectives of top-down proteomics.

PubMed

Armirotti, Andrea; Damonte, Gianluca

2010-10-01

Over the last years, top-down (TD) MS has gained a remarkable space in proteomics, rapidly trespassing the limit between a promising approach and a solid, established technique. Several research groups worldwide have implemented TD analysis in their routine work on proteomics, deriving structural information on proteins with the level of accuracy that is impossible to achieve with classical bottom-up approaches. Complete maps of PTMs and assessment of single aminoacid polymorphisms are only a few of the results that can be obtained with this technique. Despite some existing technical and economical limitations, TD analysis is at present the most powerful instrument for MS-based proteomics and its implementation in routine workflow is a rapidly approaching turning point in proteomics. In this review article, the state-of-the-art of TD approach is described along with its major advantages and drawbacks and the most recent trends in TD analysis are discussed. References for all the covered topics are reported in the text, with the aim to support both newcomers and mass spectrometrists already introduced to TD proteomics.

Advanced Design and Implementation of a Control Architecture for Long Range Autonomous Planetary Rovers

NASA Technical Reports Server (NTRS)

Martin-Alvarez, A.; Hayati, S.; Volpe, R.; Petras, R.

1999-01-01

An advanced design and implementation of a Control Architecture for Long Range Autonomous Planetary Rovers is presented using a hierarchical top-down task decomposition, and the common structure of each design is presented based on feedback control theory. Graphical programming is presented as a common intuitive language for the design when a large design team is composed of managers, architecture designers, engineers, programmers, and maintenance personnel. The whole design of the control architecture consists in the classic control concepts of cyclic data processing and event-driven reaction to achieve all the reasoning and behaviors needed. For this purpose, a commercial graphical tool is presented that includes the mentioned control capabilities. Messages queues are used for inter-communication among control functions, allowing Artificial Intelligence (AI) reasoning techniques based on queue manipulation. Experimental results show a highly autonomous control system running in real time on top the JPL micro-rover Rocky 7 controlling simultaneously several robotic devices. This paper validates the sinergy between Artificial Intelligence and classic control concepts in having in advanced Control Architecture for Long Range Autonomous Planetary Rovers.

Search for electroweak top quark production in the electron + jets channel in the D0 experiment at the Tevatron (in French)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Busato, Emmanuel

2005-04-01

The top quark, whose mass approaches the electroweak symmetry breaking scale, is by far the heaviest known elementary particle. New physics is therefore expected to have its most important effect in the top sector. The Tevatron is, currently, the only collider able to produce the top quark. Among all possible production processes in the standard model, the top-antitop pair production via strong interaction, first observed in 1995, is the one with the largest cross section. The production via electroweak interaction (known as single top production), more difficult to extract from the background because of a lower cross section and of a lower signal to background ratio, has never been observed. In this thesis, we have searched for these processes by studying proton-antiproton collisions atmore » $$\\sqrt{s}$$ =1.96 TeV produced by the Tevatron and detected with the DØ detector. The experimental study of the top quark is very sensitive to the quality of the data taken by the calorimeter. This detector showed, at the beginning of the Run II, rather important noise problems. Having identified the origin of the noise, new treatments at the offline level were implemented and their effects studied. It has been shown that these treatments reduce very significantly the effect of the noise in the reconstruction of physical quantities without notable degradation of the signal. Within the standard model, the top quark decays into W b with a branching ratio close to 100%. Leptonic decays of the into electron + neutrino have been used to identify the from the top decay. The main backgrounds to the single top signal ( +jets and QCD) are made essentially of light quark jets in the final state. Two ..-tagging algorithms have therefore been applied in order to improve the signal to background ratio. No evidence for electroweak top quark production has been found. Upper limits at the 95 % confidence level on the observed (expected) cross sections have be computed. They are found to be 14.3 (11.3) pb for the s-channel, 27.7 (21.5) pb for the t-channel and 28 (19.8) pb for the sum of the two channels.« less

Oman Drilling Project GT3 site survey: dynamics at the roof of an oceanic magma chamber

NASA Astrophysics Data System (ADS)

France, L.; Nicollet, C.; Debret, B.; Lombard, M.; Berthod, C.; Ildefonse, B.; Koepke, J.

2017-12-01

Oman Drilling Project (OmanDP) aims at bringing new constraints on oceanic crust accretion and evolution by drilling Holes in the whole ophiolite section (mantle and crust). Among those, operations at GT3 in the Sumail massif drilled 400 m to sample the dike - gabbro transition that corresponds to the top (gabbros) and roof (dikes) of the axial magma chamber, an interface where hydrothermal and magmatic system interacts. Previous studies based on oceanic crust formed at present day fast-spreading ridges and preserved in ophiolites have highlighted that this interface is a dynamic horizon where the axial melt lens that top the main magma chamber can intrude, reheat, and partially assimilate previously hydrothermally altered roof rocks. Here we present the preliminary results obtained in GT3 area that have allowed the community to choose the drilling site. We provide a geological and structural map of the area, together with new petrographic and chemical constraints on the dynamics of the dike - gabbro transition. Our new results allow us to quantify the dynamic processes, and to propose that 1/ the intrusive contact of the varitextured gabbro within the dikes highlights the intrusion of the melt lens top in the dike rooting zone, 2/ both dikes and previously crystallized gabbros are reheated, and recrystallized by underlying melt lens dynamics (up to 1050°C, largely above the hydrous solidus temperature of altered dikes and gabbros), 3/ the reheating range can be > 200°C, 4/ the melt lens depth variations for a given ridge position is > 200m, 5/ the reheating stage and associated recrystallization within the dikes occurred under hydrous conditions, 6/ the reheating stage is recorded at the root zone of the sheeted dike complex by one of the highest stable conductive thermal gradient ever recorded on Earth ( 3°C/m), 7/ local chemical variations in recrystallized dikes and gabbros are highlighted and used to quantify crystallization and anatectic processes, and the presence of trapped melt, 8/ melt lens cannibalism is attested by numerous assimilation figures close its roof. Besides providing a general context for future studies at OmanDP GT3 site, those new results allow us to quantify the dynamic processes that govern the layer 2 - layer 3 transition in ocean lithosphere.

An empirical analysis of strategy implementation process and performance of construction companies

NASA Astrophysics Data System (ADS)

Zaidi, F. I.; Zawawi, E. M. A.; Nordin, R. M.; Ahnuar, E. M.

2018-02-01

Strategy implementation is known as action stage where it is to be considered as the most difficult stage in strategic planning. Strategy implementation can influence the whole texture of a company including its performance. The aim of this research is to provide the empirical relationship between strategy implementation process and performance of construction companies. This research establishes the strategy implementation process and how it influences the performance of construction companies. This research used quantitative method approached via questionnaire survey. Respondents were G7 construction companies in Klang Valley, Selangor. Pearson correlation analysis indicate a strong positive relationship between strategy implementation process and construction companies’ performance. The most importance part of strategy implementation process is to provide sufficient training for employees which directly influence the construction companies’ profit growth and employees’ growth. This research results will benefit top management in the construction companies to conduct strategy implementation in their companies. This research may not reflect the whole construction industry in Malaysia. Future research may be resumed to small and medium grades contractors and perhaps in other areas in Malaysia.

A Story of a Journey in Implementing an E-Assessment System at a South African University

ERIC Educational Resources Information Center

Singh, U. G.; Wassermann, J. M.

2016-01-01

Following the challenges faced in the selection and implementation of e-assessment tools for student assessment, I undertook a journey of implementing an e-assessment system within the University of KwaZulu-Natal (UKZN). This article describes the path traversed and highlights the potholes and expressways on this road towards e-assessment…

A Method for Label-Free, Differential Top-Down Proteomics.

PubMed

Ntai, Ioanna; Toby, Timothy K; LeDuc, Richard D; Kelleher, Neil L

2016-01-01

Biomarker discovery in the translational research has heavily relied on labeled and label-free quantitative bottom-up proteomics. Here, we describe a new approach to biomarker studies that utilizes high-throughput top-down proteomics and is the first to offer whole protein characterization and relative quantitation within the same experiment. Using yeast as a model, we report procedures for a label-free approach to quantify the relative abundance of intact proteins ranging from 0 to 30 kDa in two different states. In this chapter, we describe the integrated methodology for the large-scale profiling and quantitation of the intact proteome by liquid chromatography-mass spectrometry (LC-MS) without the need for metabolic or chemical labeling. This recent advance for quantitative top-down proteomics is best implemented with a robust and highly controlled sample preparation workflow before data acquisition on a high-resolution mass spectrometer, and the application of a hierarchical linear statistical model to account for the multiple levels of variance contained in quantitative proteomic comparisons of samples for basic and clinical research.

Treatment of Dyslipidemia Using CRISPR/Cas9 Genome Editing.

PubMed

Chadwick, Alexandra C; Musunuru, Kiran

2017-07-01

Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated 9 (Cas9) has recently emerged as a top genome editing technology and has afforded investigators the ability to more easily study a number of diseases. This review discusses CRISPR/Cas9's advantages and limitations and highlights a few recent reports on genome editing applications for alleviating dyslipidemia through disruption of proprotein convertase subtilisin/kexin type 9 (PCSK9). Targeting of mouse Pcsk9 using CRISPR/Cas9 technology has yielded promising results for lowering total cholesterol levels, and several recent findings are highlighted in this review. Reported on-target mutagenesis efficiency is as high as 90% with a subsequent 40% reduction of blood cholesterol levels in mice, highlighting the potential for use as a therapeutic in human patients. The ability to characterize and treat diseases is becoming easier with the recent advances in genome editing technologies. In this review, we discuss how genome editing strategies can be of use for potential therapeutic applications.

Top down and bottom up selection drives variations in frequency and form of a visual signal.

PubMed

Yeh, Chien-Wei; Blamires, Sean J; Liao, Chen-Pan; Tso, I-Min

2015-03-30

The frequency and form of visual signals can be shaped by selection from predators, prey or both. When a signal simultaneously attracts predators and prey selection may favour a strategy that minimizes risks while attracting prey. Accordingly, varying the frequency and form of the silken decorations added to their web may be a way that Argiope spiders minimize predation while attracting prey. Nonetheless, the role of extraneous factors renders the influences of top down and bottom up selection on decoration frequency and form variation difficult to discern. Here we used dummy spiders and decorations to simulate four possible strategies that the spider Argiope aemula may choose and measured the prey and predator attraction consequences for each in the field. The strategy of decorating at a high frequency with a variable form attracted the most prey, while that of decorating at a high frequency with a fixed form attracted the most predators. These results suggest that mitigating the cost of attracting predators while maintaining prey attraction drives the use of variation in decoration form by many Argiope spp. when decorating frequently. Our study highlights the importance of considering top-down and bottom up selection pressure when devising evolutionary ecology experiments.

Proteomics in Heart Failure: Top-down or Bottom-up?

PubMed Central

Gregorich, Zachery R.; Chang, Ying-Hua; Ge, Ying

2014-01-01

Summary The pathophysiology of heart failure (HF) is diverse, owing to multiple etiologies and aberrations in a number of cellular processes. Therefore, it is essential to understand how defects in the molecular pathways that mediate cellular responses to internal and external stressors function as a system to drive the HF phenotype. Mass spectrometry (MS)-based proteomics strategies have great potential for advancing our understanding of disease mechanisms at the systems level because proteins are the effector molecules for all cell functions and, thus, are directly responsible for determining cell phenotype. Two MS-based proteomics strategies exist: peptide-based bottom-up and protein-based top-down proteomics—each with its own unique strengths and weaknesses for interrogating the proteome. In this review, we will discuss the advantages and disadvantages of bottom-up and top-down MS for protein identification, quantification, and the analysis of post-translational modifications, as well as highlight how both of these strategies have contributed to our understanding of the molecular and cellular mechanisms underlying HF. Additionally, the challenges associated with both proteomics approaches will be discussed and insights will be offered regarding the future of MS-based proteomics in HF research. PMID:24619480

Corporate compliance plans in health care organizations: a top-down perspective.

PubMed

Forgione, D A

1998-01-01

Recently, at an all-day professional meeting that was targeted at about 100 junior-level health care financial professionals, we covered a whole spectrum of subjects. We covered topics ranging from the Hill-Burton Act to Medicare managed care organizations (MCOs) and capitation; the Stark rules on physician self-referral; the financial incentives within various payment systems for physicians, hospitals, and other providers; Medicare fraud and abuse rules; and the need for well-designed corporate compliance plans. After responding to a number of the participants' questions, I could not help but be reminded of the students every semester who ask me, "Will this be on the test?" In other words, if there are no real teeth in the subject, then they have too many other urgent priorities demanding their attention to give the issue serious consideration. Perhaps this highlights the need for taking corporate compliance planning seriously--starting at the top levels of the organization. It is well documented that leadership attitudes filter downward in any organization. If change for the better is going to take place in the area of corporate compliance, it needs to begin with each of us as individuals, from the top down.

Designing, Developing, and Implementing Diversity Training: Guidelines for Practitioners.

ERIC Educational Resources Information Center

Kincaid, Tanna M.; Horner, Erin R.

1997-01-01

Discusses diversity in the workplace and offers guidelines for practitioners in designing, developing, and implementing diversity training. Highlights include linking the diversity initiative to the organization's mission, cultural climate assessments, reviewing policies and procedures, needs assessment, learner analysis, establishing objectives,…

A before-after study of multidisciplinary Out-of-Hours handover: combining management and frontline efforts to create sustainable improvement.

PubMed

Pennell, Christopher; Flynn, Lorna; Boulton, Belinda; Hughes, Tracey; Walker, Graham; McCulloch, Peter

2017-04-01

The importance of implementation strategy in systems improvement is increasingly recognized and both 'bottom-up' and 'top-down' approaches have significant barriers. A trial of a combined approach involving frontline and managerial staff therefore seems merited. We attempted to improve handover using a Human Factors-based approach integrated with a combined 'top and bottom' implementation strategy. A before-after study was conducted across 9 months. The study was set in a 236 bed district general hospital. Participants included any member of staff involved in Out of Hours handover. Existing processes were analysed using Human Factors methods. Changes made were based on this analysis and developed via facilitation between management and frontline staff. These included creating a single multidisciplinary handover, changing the venue, standardizing the meeting structure, developing an standard operating procedure for identifying unwell patients for handover and creating a clinical coordinator role. Meeting attendance, duration, start time efficiency, the type of patients handed over and the transfer of important information were measured pre- and post-intervention. We found improvement in handover start time (P = 0.002, r = 0) and multidisciplinary participation (P = 0.002, r = -0.534). Handover of unwell patients improved, but not significantly. Communication of plan (P < 0.001, r = 0.14) and pending tasks (P < 0.001, r = 0.30) improved, but diagnosis (P = 0.233, r = -0.05), history (P = 0.482, r = -0.03) and comorbidities (P = 0.19, r = -0.05) did not. The changes produced greater multidisciplinary participation, a broader focus and improved communication of plans and tasks outstanding. The 'top and bottom' implementation approach appeared valuable. Management involvement was essential for significant changes, while frontline staff involvement facilitated the design of context-specific practical solutions with staff buy-in. © The Author 2017. Published by Oxford University Press in association with the International Society for Quality in Health Care. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

A prototype table-top inverse-geometry volumetric CT system.

PubMed

Schmidt, Taly Gilat; Star-Lack, Josh; Bennett, N Robert; Mazin, Samuel R; Solomon, Edward G; Fahrig, Rebecca; Pelc, Norbert J

2006-06-01

A table-top volumetric CT system has been implemented that is able to image a 5-cm-thick volume in one circular scan with no cone-beam artifacts. The prototype inverse-geometry CT (IGCT) scanner consists of a large-area, scanned x-ray source and a detector array that is smaller in the transverse direction. The IGCT geometry provides sufficient volumetric sampling because the source and detector have the same axial, or slice direction, extent. This paper describes the implementation of the table-top IGCT scanner, which is based on the NexRay Scanning-Beam Digital X-ray system (NexRay, Inc., Los Gatos, CA) and an investigation of the system performance. The alignment and flat-field calibration procedures are described, along with a summary of the reconstruction algorithm. The resolution and noise performance of the prototype IGCT system are studied through experiments and further supported by analytical predictions and simulations. To study the presence of cone-beam artifacts, a "Defrise" phantom was scanned on both the prototype IGCT scanner and a micro CT system with a +/-5 cone angle for a 4.5-cm volume thickness. Images of inner ear specimens are presented and compared to those from clinical CT systems. Results showed that the prototype IGCT system has a 0.25-mm isotropic resolution and that noise comparable to that from a clinical scanner with equivalent spatial resolution is achievable. The measured MTF and noise values agreed reasonably well with theoretical predictions and computer simulations. The IGCT system was able to faithfully reconstruct the laminated pattern of the Defrise phantom while the micro CT system suffered severe cone-beam artifacts for the same object. The inner ear acquisition verified that the IGCT system can image a complex anatomical object, and the resulting images exhibited more high-resolution details than the clinical CT acquisition. Overall, the successful implementation of the prototype system supports the IGCT concept for single-rotation volumetric scanning free from cone-beam artifacts.

Probing the transition from shallow to deep convection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kuang, Zhiming; Gentine, Pierre

2016-05-01

In this funded project we highlighted the components necessary for the transition from shallow to deep convection. In particular we defined a prototype of shallow to deep convection, which is currently being implemented in the NASA GISS model. We also tried to highlight differences between land and oceanic convection.

Implementing enhanced recovery pathways: a literature review with realist synthesis.

PubMed

Coxon, Astrid; Nielsen, Karina; Cross, Jane; Fox, Chris

2017-10-01

Enhanced Recovery Pathways (ERPs) are an increasingly popular, evidenced-based approach to surgery, designed to improve patient outcomes and reduce costs. Despite evidence demonstrating the benefits of these pathways, implementation and adherence have been inconsistent. Using realist synthesis, this review explored the current literature surrounding the implementation of ERPs in the UK. Knowledge consolidation between authors and consulting with field experts helped to guide the search strategy. Relevant medical and social science databases were searched from 2000 to 2016, as well as a general web search. A total of 17 papers were identified, including original research, reviews, case studies and guideline documents. Full texts were analysed, cross-examined, and data extracted and synthesised. Several implementation strategies were identified, including the contexts in which these operated, the subsequent mechanisms of action that were triggered, and the outcome patterns they produced. Context-Mechanism-Outcome (CMO) configurations were generated, tested, and refined. These were grouped to develop two programme theories concerning ERP implementation, one related to the strategy of consulting with staff, the other with appointing a change agent to coordinate and drive the implementation process. These theories highlight instances in which implementation could be improved. Current literature in ERP research is primarily focussed on measuring patient outcomes and cost effectiveness, and as a result, important detail regarding the implementation process is often not reported or described robustly. This review not only provides recommendations for future improvements in ERP implementation, but also highlights specific areas of focus for furthering ERP implementation research.

Abundant Lysine Methylation and N-Terminal Acetylation in Sulfolobus islandicus Revealed by Bottom-Up and Top-Down Proteomics*

PubMed Central

Vorontsov, Egor A.; Rensen, Elena; Prangishvili, David; Krupovic, Mart; Chamot-Rooke, Julia

2016-01-01

Protein post-translational methylation has been reported to occur in archaea, including members of the genus Sulfolobus, but has never been characterized on a proteome-wide scale. Among important Sulfolobus proteins carrying such modification are the chromatin proteins that have been described to be methylated on lysine side chains, resembling eukaryotic histones in that aspect. To get more insight into the extent of this modification and its dynamics during the different growth steps of the thermoacidophylic archaeon S. islandicus LAL14/1, we performed a global and deep proteomic analysis using a combination of high-throughput bottom-up and top-down approaches on a single high-resolution mass spectrometer. 1,931 methylation sites on 751 proteins were found by the bottom-up analysis, with methylation sites on 526 proteins monitored throughout three cell culture growth stages: early-exponential, mid-exponential, and stationary. The top-down analysis revealed 3,978 proteoforms arising from 681 proteins, including 292 methylated proteoforms, 85 of which were comprehensively characterized. Methylated proteoforms of the five chromatin proteins (Alba1, Alba2, Cren7, Sul7d1, Sul7d2) were fully characterized by a combination of bottom-up and top-down data. The top-down analysis also revealed an increase of methylation during cell growth for two chromatin proteins, which had not been evidenced by bottom-up. These results shed new light on the ubiquitous lysine methylation throughout the S. islandicus proteome. Furthermore, we found that S. islandicus proteins are frequently acetylated at the N terminus, following the removal of the N-terminal methionine. This study highlights the great value of combining bottom-up and top-down proteomics for obtaining an unprecedented level of accuracy in detecting differentially modified intact proteoforms. The data have been deposited to the ProteomeXchange with identifiers PXD003074 and PXD004179. PMID:27555370

Climate-mediated changes in marine ecosystem regulation during El Niño.

PubMed

Lindegren, Martin; Checkley, David M; Koslow, Julian A; Goericke, Ralf; Ohman, Mark D

2018-02-01

The degree to which ecosystems are regulated through bottom-up, top-down, or direct physical processes represents a long-standing issue in ecology, with important consequences for resource management and conservation. In marine ecosystems, the role of bottom-up and top-down forcing has been shown to vary over spatio-temporal scales, often linked to highly variable and heterogeneously distributed environmental conditions. Ecosystem dynamics in the Northeast Pacific have been suggested to be predominately bottom-up regulated. However, it remains unknown to what extent top-down regulation occurs, or whether the relative importance of bottom-up and top-down forcing may shift in response to climate change. In this study, we investigate the effects and relative importance of bottom-up, top-down, and physical forcing during changing climate conditions on ecosystem regulation in the Southern California Current System (SCCS) using a generalized food web model. This statistical approach is based on nonlinear threshold models and a long-term data set (~60 years) covering multiple trophic levels from phytoplankton to predatory fish. We found bottom-up control to be the primary mode of ecosystem regulation. However, our results also demonstrate an alternative mode of regulation represented by interacting bottom-up and top-down forcing, analogous to wasp-waist dynamics, but occurring across multiple trophic levels and only during periods of reduced bottom-up forcing (i.e., weak upwelling, low nutrient concentrations, and primary production). The shifts in ecosystem regulation are caused by changes in ocean-atmosphere forcing and triggered by highly variable climate conditions associated with El Niño. Furthermore, we show that biota respond differently to major El Niño events during positive or negative phases of the Pacific Decadal Oscillation (PDO), as well as highlight potential concerns for marine and fisheries management by demonstrating increased sensitivity of pelagic fish to exploitation during El Niño. © 2017 John Wiley & Sons Ltd.

Highlights in bioethics through 40 years: a quantitative analysis of top-cited journal articles.

PubMed

Jin, Pingyue; Hakkarinen, Mark

2017-05-01

The field of bioethics is constantly evolving. To investigate trends in the field of bioethics, we conducted a quantitative analysis of the top-cited articles in bioethical journals over the past 40 years. Retrospective quantitative study of the 20 most cited bioethics articles published each year from 1975 to 2014 were conducted. Article samples were selected from a list of the most relevant 100 journals in the field of bioethics. In total, 800 top-cited articles between 1975 and 2014 in the domain of bioethics were retrieved and analysed. More than half of them were composed by single authors, but multiauthorship became more prevalent with time. The majority (84.5%) of these highly cited articles originated from the USA (65.3%), UK or Canada, though the proportion of other countries increased in recent years. Almost half (44.6%) of the highly cited articles belonged to the subfield of clinical ethics , but other subfields such as research ethics , public health ethics and neuroethics became more prominent. Overall, the distribution of Thesaurus keywords and subfields became more diverse over time, and the number of journals publishing top-cited articles doubled. Furthermore, the empirical ethics approach increased over time in our sample of top-cited articles. In sum, the forefront of bioethics is getting more diversified, collaborative and international. The presumed 'mainstream' becomes less dominant over time, as more highly cited articles come from new subfields, discuss new topics, use more Bioethics Thesaurus keywords, more authors participate and more countries other than the USA contribute to bioethics journals. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

A Scientific Analysis of the 100 Citation Classics of Valvular Heart Disease.

PubMed

Usman, Muhammad Shariq; Siddiqi, Tariq Jamal; Khan, Muhammad Shahzeb; Fatima, Kaneez; Butler, Javed; Manning, Warren J; Khosa, Faisal

2017-10-15

Bibliometric analyses can help researchers and research funding agencies determine which areas of medicine need appropriate research attention. Citation classics of several specialties and subspecialties have been published; however, a literature search did not turn up any in the field of valvular heart disease (VHD). The main objective of this analysis was to overcome this paucity by identifying the top 100 cited articles in VHD and to assess their characteristics. We chose Scopus as our database, from where relevant articles were extracted after a thorough search by 2 independent researchers. A list of the top 100 cited articles was prepared, after which a detailed analysis of the list was conducted. The top-cited articles were published in the 63-year era starting from 1951, with the most articles published in the 10-year interval of 2001 to 2010. The citations of the articles ranged from 438 to 2,717 with a median of 609.5. Manuscripts from our top-cited list originated from 25 different countries. Most of the articles in the top 100 list were published in high-impact journals, with about a third of the articles published in Circulation (n = 27). Our study also reveals that the current focus of researchers in the field is on transcatheter aortic valve replacement, and therefore, funding in this area is likely to result in impactful studies. In conclusion, our study highlights the characteristics of high-impact articles in the field of VHD, and this information may be useful for investigators planning to conduct studies in this area of medicine in the future. Copyright © 2017 Elsevier Inc. All rights reserved.

Recent highlights from IceCube

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kappes, A.; Collaboration: IceCube Collaboration

2014-11-18

The IceCube Neutrino Observatory, completed in December 2010, is located at the geographic South Pole and incorporates a one cubic kilometer neutrino detector buried in the deep ice and a one square kilometer air shower array, IceTop, sitting atop the glacial ice. This unique combination of neutrino and cosmic-ray detectors allows to investigate a wide variety of physics topics both in astrophysics and particle physics. Here, we discuss latest results from IceCube concentrating on astrophysical aspects.

KSC-03pd0077

NASA Image and Video Library

2003-01-15

KENNEDY SPACE CENTER, FLA. -- The late afternoon sun highlights the external tank and solid rocket booster on Space Shuttle Columbia after rollback of the Rotating Service Structure on Launch Pad 39A. Visible are the orbiter access arm with the White Room extended to Columbia's cockpit, and at the top, the gaseous oxygen vent arm and cap, called the "beanie cap." Columbia is scheduled for launch Jan. 16 at 10:39 a.m. EST on mission STS-107, a research mission.

KSC-03pd0074

NASA Image and Video Library

2003-01-15

KENNEDY SPACE CENTER, FLA. -- The late afternoon sun highlights the external tank and solid rocket booster on Space Shuttle Columbia after rollback of the Rotating Service Structure on Launch Pad 39A. Visible are the orbiter access arm with the White Room extended to Columbia's cockpit, and at the top, the gaseous oxygen vent arm and cap, called the "beanie cap." Columbia is scheduled for launch Jan. 16 at 10:39 a.m. EST on mission STS-107, a research mission.

ARM Climate Research Facility Quarterly Ingest Status Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koontz, A.; Sivaraman, C.

2016-10-01

The purpose of this report is to provide a concise status update for ingests maintained by the Atmospheric Radiation Measurement (ARM) Climate Research Facility. The report is divided into the following sections: (1) new ingests for which development has begun, (2) progress on existing ingests, (3) future ingests that have been recently approved, (4) other work that leads to an ingest, and (5) top requested ingests from the ARM Data Archive. New information is highlighted in blue text.

ARM Climate Research Facility Quarterly Ingest Status Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koontz, A.; Sivaraman, C.

2016-07-01

The purpose of this report is to provide a concise status update for ingests maintained by the Atmospheric Radiation Measurement (ARM) Climate Research Facility. The report is divided into the following sections: (1) new ingests for which development has begun, (2) progress on existing ingests, (3) future ingests that have been recently approved, (4) other work that leads to an ingest, and (5) top requested ingests from the ARM Data Archive. New information is highlighted in blue text.

Earth Observations taken by Expedition 26 crewmember

NASA Image and Video Library

2011-01-06

ISS026-E-015208 (6 Jan. 2011) --- Photographed by an Expedition 26 crew member on the International Space Station, this detailed photograph highlights the northern approach to Mount Everest from Tibet. Known as the northeast ridge route, climbers travel along the East Rongbuk Glacier (top right) to camp at the base of Changtse mountain. From this point at approximately 6,100 meters above sea level, the North Col--a sharp-edged pass carved by glaciers, center--is ascended to reach a series of progressively higher camps along the North Face of Everest, culminating in Camp VI at 8,230 meters above sea level. Climbers make their final push to the summit (not visible, just off the bottom edge of the image) from this altitude. While the near-nadir viewing angle--almost looking "straight down" from the International Space Station--tends to flatten the topography, crew members have also taken images that highlight the rugged nature of the area. Everest (or Sagarmatha in Nepali), located within the Himalaya mountain chain, is Earth’s highest mountain with its summit at 8,848 meters above sea level. Khumbutse mountain, visible at top left, has a summit elevation of 6,640 meters above sea level. Climbing to the summit of Everest requires much advance planning, conditioning, and situational awareness on the part of mountaineers to avoid potentially fatal consequences--as of 2010, there have been over 200 reported fatalities.

A Virtual Screening Approach For Identifying Plants with Anti H5N1 Neuraminidase Activity

PubMed Central

2016-01-01

Recent outbreaks of highly pathogenic and occasional drug-resistant influenza strains have highlighted the need to develop novel anti-influenza therapeutics. Here, we report computational and experimental efforts to identify influenza neuraminidase inhibitors from among the 3000 natural compounds in the Malaysian-Plants Natural-Product (NADI) database. These 3000 compounds were first docked into the neuraminidase active site. The five plants with the largest number of top predicted ligands were selected for experimental evaluation. Twelve specific compounds isolated from these five plants were shown to inhibit neuraminidase, including two compounds with IC50 values less than 92 μM. Furthermore, four of the 12 isolated compounds had also been identified in the top 100 compounds from the virtual screen. Together, these results suggest an effective new approach for identifying bioactive plant species that will further the identification of new pharmacologically active compounds from diverse natural-product resources. PMID:25555059

Attention distributed across sensory modalities enhances perceptual performance

PubMed Central

Mishra, Jyoti; Gazzaley, Adam

2012-01-01

This study investigated the interaction between top-down attentional control and multisensory processing in humans. Using semantically congruent and incongruent audiovisual stimulus streams, we found target detection to be consistently improved in the setting of distributed audiovisual attention versus focused visual attention. This performance benefit was manifested as faster reaction times for congruent audiovisual stimuli, and as accuracy improvements for incongruent stimuli, resulting in a resolution of stimulus interference. Electrophysiological recordings revealed that these behavioral enhancements were associated with reduced neural processing of both auditory and visual components of the audiovisual stimuli under distributed vs. focused visual attention. These neural changes were observed at early processing latencies, within 100–300 ms post-stimulus onset, and localized to auditory, visual, and polysensory temporal cortices. These results highlight a novel neural mechanism for top-down driven performance benefits via enhanced efficacy of sensory neural processing during distributed audiovisual attention relative to focused visual attention. PMID:22933811

A Paleozoological Perspective on White-Tailed Deer ( Odocoileus virginianus texana) Population Density and Body Size in Central Texas

NASA Astrophysics Data System (ADS)

Wolverton, Steve; Kennedy, James H.; Cornelius, John D.

2007-04-01

Archaeological and paleontological datasets are used in conservation to add time-depth to ecology. In central Texas, several top carnivores including prehistoric Native American hunters have been extirpated or have had their historic ranges restricted, which has resulted in pest-level white-tailed deer ( Odocoileus virginianus texana) populations in some areas. Differences in body size of deer between prehistory and modernity are expected, given that a lack of predation likely has increased intraspecific competition for forage among deer, resulting in smaller body size today. In fact, modern deer from settings without harvest pressure are significantly smaller than those from harvested areas and from prehistoric deer. From a natural history perspective, this research highlights potential evolutionary causes and effects of top-predator removal on deer populations and related components of biological communities in central Texas.

Highlights in asthma 2005.

PubMed

Heraghty, J L; Henderson, A J

2006-05-01

It is usual at the end of a year for top tens to feature large in our collective consciousness. These inevitably include the occasional controversial selection and without fail will overlook a number of gems, whether in the field of literature, art, or science. The approaches to such compilations include personal selections, convening expert committees through to letting the market decide. However, it is well recognised that experts can be wrong and markets distorted. A novel approach to identifying the key publications in the field of medicine, Faculty of 1000 Medicine (http://www.f1000medicine.com), uses faculty evaluations to assign ratings to published papers within topics and categories, bringing a flavour of the dynamism of post hoc peer review to biological sciences that exists in other fields of scholarship. Archives of Disease in Childhood has also developed a market led system of peer evaluation through its web based top ten most read articles feature.

Predictions penetrate perception: Converging insights from brain, behaviour and disorder

PubMed Central

O’Callaghan, Claire; Kveraga, Kestutis; Shine, James M; Adams, Reginald B.; Bar, Moshe

2018-01-01

It is argued that during ongoing visual perception, the brain is generating top-down predictions to facilitate, guide and constrain the processing of incoming sensory input. Here we demonstrate that these predictions are drawn from a diverse range of cognitive processes, in order to generate the richest and most informative prediction signals. This is consistent with a central role for cognitive penetrability in visual perception. We review behavioural and mechanistic evidence that indicate a wide spectrum of domains—including object recognition, contextual associations, cognitive biases and affective state—that can directly influence visual perception. We combine these insights from the healthy brain with novel observations from neuropsychiatric disorders involving visual hallucinations, which highlight the consequences of imbalance between top-down signals and incoming sensory information. Together, these lines of evidence converge to indicate that predictive penetration, be it cognitive, social or emotional, should be considered a fundamental framework that supports visual perception. PMID:27222169

FAA perspectives on historical wake turbulence R&D to recent operational implementations

DOT National Transportation Integrated Search

2017-06-03

A major intent of this presentation is to delineate why the many years of wake turbulence R&D are finally yielding beneficial operational implementations. It will highlight lessons learned from past R&D and going forward for NextGen and beyond.

New York City's Strategy for Improving High Schools: An Overview

ERIC Educational Resources Information Center

Alliance for Excellent Education, 2010

2010-01-01

As the nation has embraced the need to graduate every student ready for college and careers, high school reform has emerged at the top of the education agenda. Many local and state leaders are implementing strategies to address low performance and close achievement gaps. As federal policymakers look ahead to opportunities to support this…

Making Mobile Learning Work: Student Perceptions and Implementation Factors

ERIC Educational Resources Information Center

Tabor, Sharon W.

2016-01-01

Mobile devices are the constant companions of technology users of all ages. Studies show, how-ever, that making calls is a minimal part of our engagement with today's smart phones and that even texting has fallen off, leaving web browsing, gaming, and social media as top uses. A cross-disciplinary group of faculty at our university came together…

Sponsorshaping: How a Teacher Used Sponsors of Literacy for Pedagogical Purposes

ERIC Educational Resources Information Center

Dippre, Ryan

2016-01-01

Historically, the actions of classroom teachers have had a massive impact on the implementation of top-down reform efforts. However, a pedagogically-friendly construct for considering this impact has been lacking in studies of teacher practice. In this article, I draw on Deborah Brandt's concept of sponsors of literacy to build a construct for…

The National Mentoring Program in Israel--Challenges and Achievements

ERIC Educational Resources Information Center

Zorman, Rachel; Rachmel, Shlomit; Bashan, Zipi

2016-01-01

The National Mentoring Program was created in 2009 by the Division for Gifted and Outstanding Students in the Ministry of Education and is implemented by the Szold Institute. The program aims to cultivate future leaders in Israel. Highly gifted 10th and 11th graders are matched with top rate professionals in students' areas of interest. They work…

Engagement through Microblogging: Educator Professional Development via Twitter

ERIC Educational Resources Information Center

Carpenter, Jeffrey P.; Krutka, Daniel G.

2015-01-01

Traditional, top-down professional development (PD) can render teachers mere implementers of the ideas of others, but there is some hope that the participatory nature of social media such as Twitter might support more grassroots PD. To better understand Twitter's role in education, we conducted a survey of K-16 educators regarding their use of the…

The State Education Agency: At the Helm, Not the Oar

ERIC Educational Resources Information Center

Smarick, Andy; Squire, Juliet

2014-01-01

Never before has more been asked of State Education Agencies (SEAs), commonly known as state departments of education. In recent years, policymakers at the state and federal level have viewed the SEA as the default entity for implementing new and sweeping K-12 initiatives--everything from Race to the Top grants and SEA waivers to teacher…

The Effects of School Turnaround in Tennessee's Achievement School District and Innovation Zones

ERIC Educational Resources Information Center

Zimmer, Ron; Henry, Gary T.; Kho, Adam

2017-01-01

In recent years, the federal government has invested billions of dollars to reform chronically low-performing schools. To fulfill their federal Race to the Top grant agreement, Tennessee implemented three turnaround strategies that adhered to the federal restart and transformation models: (a) placed schools under the auspices of the Achievement…

Robotic Intelligence Kernel: Driver

DOE Office of Scientific and Technical Information (OSTI.GOV)

The INL Robotic Intelligence Kernel-Driver is built on top of the RIK-A and implements a dynamic autonomy structure. The RIK-D is used to orchestrate hardware for sensing and action as well as software components for perception, communication, behavior and world modeling into a single cognitive behavior kernel that provides intrinsic intelligence for a wide variety of unmanned ground vehicle systems.

Do Schools Respond to Pressure? Evidence from NCLB Implementation Details

ERIC Educational Resources Information Center

Wong, Vivian C.; Wing, Coady; Martin, David

2016-01-01

Over the last decade, accountability reform has been at the forefront of the domestic policy agenda. Although the Obama Administration was critical of some elements of No Child Left Behind (NCLB), its policies endorsed high-stakes testing and expanded the scope of the stakes. With the Race to the Top and an NCLB waiver process, the administration…

Onboard FPGA-based SAR processing for future spaceborne systems

NASA Technical Reports Server (NTRS)

Le, Charles; Chan, Samuel; Cheng, Frank; Fang, Winston; Fischman, Mark; Hensley, Scott; Johnson, Robert; Jourdan, Michael; Marina, Miguel; Parham, Bruce;

The Effectiveness of Public Participation in Developing and Implementing Tourism Plans for Two Peruvian Protected Areas

ERIC Educational Resources Information Center

De la Cruz-Novey, H. Alicia

2012-01-01

In the last two decades protected area management approaches have experienced a shift from top-down management models to more diverse governance approaches that involve various forms and degrees of participation from local populations. These new participatory approaches seek to reaffirm cultural values, maintain cultural landscapes, recognize the…

Utilizing BlueJ to Teach Polymorphism in an Advanced Object-Oriented Programming Course

ERIC Educational Resources Information Center

Alkazemi, Basem Y.; Grami, Grami M.

2012-01-01

Teaching Polymorphism can be best implemented by using a combination of bottom-up and top-down approaches. However, from our observation and students' self-reporting, the former seems to be the predominant in the Saudi context. We try to investigate whether applying a more balanced approach in teaching the comprehensive concept of Polymorphism…

Measuring Teacher Effectiveness: The Impact of Institutional Culture on Initial Implementation of New York's Annual Professional Performance Review

ERIC Educational Resources Information Center

Champ, Cheryl H.

2015-01-01

As part of the "American Reinvestment and Recovery Act of 2009," the U.S. Department of Education sponsored the "Race to the Top" competition to encourage education reforms anchored in improving teacher effectiveness as a driver for improving student-achievement outcomes and closing achievement gaps. The New York State…

EVALUATION OF SELECTED DNA-BASED TECHNOLOGY IN IMPAIRED WATERSHEDS IMPACTED BY FECAL CONTAMINATION FROM DIVERSE SOURCES

EPA Science Inventory

Fecal pollution of surface waters is a top reason for impairment, as listed by the U.S. Environmental Protection Agency’s report on the quality of the Nation's waters. To be able to develop and implement TMDLs in impaired aquatic resources, it is imperative to determine the sourc...

Reflection on the Education Policy Orientation in Post-May 31 Reform in Korea

ERIC Educational Resources Information Center

Lee, Chong Jae; Kim, Yong

2016-01-01

For the last 70 years, since the establishment of the Republic of Korea, Korean education has achieved universal expansion of educational opportunity from elementary to secondary to higher education. Planning, centralized policy making, top-down implementation, and administrative control had been the standards of the first few decades of Korean…