Scaled CMOS Reliability and Considerations for Spacecraft Systems: Bottom-Up and Top-Down Perspective

NASA Technical Reports Server (NTRS)

White, Mark

2012-01-01

New space missions will increasingly rely on more advanced technologies because of system requirements for higher performance, particularly in instruments and high-speed processing. Component-level reliability challenges with scaled CMOS in spacecraft systems from a bottom-up perspective have been presented. Fundamental Front-end and Back-end processing reliability issues with more aggressively scaled parts have been discussed. Effective thermal management from system-level to the componentlevel (top-down) is a key element in overall design of reliable systems. Thermal management in space systems must consider a wide range of issues, including thermal loading of many different components, and frequent temperature cycling of some systems. Both perspectives (top-down and bottom-up) play a large role in robust, reliable spacecraft system design.

Thermionic Energy Conversion (TEC) topping thermoelectrics

NASA Technical Reports Server (NTRS)

Morris, J. F.

1981-01-01

Performance expectations for thermionic and thermoelectric energy conversion systems are reviewed. It is noted that internal radiation effects diminish thermoelectric figures of merit significantly at 1000 K and substantially at 2000 K; the effective thermal conductivity contribution of intrathermoelectric radiative dissipation increases with the third power of temperature. It is argued that a consideration of thermoelectric power generation with high temperature heat sources should include utilization of thermionic energy conversion (TEC) topping thermoelectrics. However TEC alone or TEC topping more efficient conversion systems like steam or gas turbines, combined cycles, or Stirling engines would be more desirable generally.

Thermal barrier coating life prediction model

NASA Technical Reports Server (NTRS)

Hillery, R. V.; Pilsner, B. H.

1985-01-01

This is the first report of the first phase of a 3-year program. Its objectives are to determine the predominant modes of degradation of a plasma sprayed thermal barrier coating system, then to develop and verify life prediction models accounting for these degradation modes. The first task (Task I) is to determine the major failure mechanisms. Presently, bond coat oxidation and bond coat creep are being evaluated as potential TBC failure mechanisms. The baseline TBC system consists of an air plasma sprayed ZrO2-Y2O3 top coat, a low pressure plasma sprayed NiCrAlY bond coat, and a Rene'80 substrate. Pre-exposures in air and argon combined with thermal cycle tests in air and argon are being utilized to evaluate bond coat oxidation as a failure mechanism. Unexpectedly, the specimens pre-exposed in argon failed before the specimens pre-exposed in air in subsequent thermal cycles testing in air. Four bond coats with different creep strengths are being utilized to evaluate the effect of bond coat creep on TBC degradation. These bond coats received an aluminide overcoat prior to application of the top coat to reduce the differences in bond coat oxidation behavior. Thermal cycle testing has been initiated. Methods have been selected for measuring tensile strength, Poisson's ratio, dynamic modulus and coefficient of thermal expansion both of the bond coat and top coat layers.

Numerical investigations of failure in EB-PVD thermal barrier coating systems

NASA Astrophysics Data System (ADS)

Glynn, Michael L.

Thermal barrier coating (TBC) systems are used in high temperature applications in turbine engines. TBCs are applied on superalloy substrates and are multilayered coatings comprised of a metallic bond coat, a thermally grown oxide (TGO) and a ceramic top coat. They provide thermal protection for the superalloy substrate and are considered to hold the greatest potential for increased operating temperatures. Failure of the TBC system most commonly occurs as a result of large scale buckling and spallation. The buckling is a consequence of many small-scale delaminations that arise in the top coat above local imperfections in the TGO, and durability of the TBC system is governed by a sequence of crack nucleation, propagation and coalescence. The numerical investigations that are employed in this dissertation are used to determine the stress development near the imperfections and are based on microstructural observations and measured material properties of TBC test buttons supplied by GE Aircraft Engines. The test buttons were subject to thermal cycling at GE and cycled to different percentages of TBC life. Numerical simulations of two different types of TBC tests are used to show that the top coat out-of-plane stress increases with a decrease of the substrate radius of curvature and a decrease in the heating rate. An inherent scaling parameter in the TBC system is identified and used to demonstrate that the stress developed in the top coat is governed by the evolution of an imperfection in the TGO. The effect of a martensitic phase transformation in the bond coat, related to a change in bond coat chemistry, is shown to significantly increase the top coat out-of-plane tensile stress. Finally, a subsurface crack is simulated in the top coat and used to determine the influence of the bond coat on failure of the TBC system. While the bond coat inelastic properties are the most important factors in determining the extent of the crack opening displacement, the bond coat martensitic phase transformation governs when the crack propagates. The crack propagates during heat-up when the martensitic phase transformation is included, and it propagates during cool-down when the transformation is not included.

Sequences within the 5' untranslated region regulate the levels of a kinetoplast DNA topoisomerase mRNA during the cell cycle.

PubMed Central

Pasion, S G; Hines, J C; Ou, X; Mahmood, R; Ray, D S

1996-01-01

Gene expression in trypanosomatids appears to be regulated largely at the posttranscriptional level and involves maturation of mRNA precursors by trans splicing of a 39-nucleotide miniexon sequence to the 5' end of the mRNA and cleavage and polyadenylation at the 3' end of the mRNA. To initiate the identification of sequences involved in the periodic expression of DNA replication genes in trypanosomatids, we have mapped splice acceptor sites in the 5' flanking region of the TOP2 gene, which encodes the kinetoplast DNA topoisomerase, and have carried out deletion analysis of this region on a plasmid-encoded TOP2 gene. Block deletions within the 5' untranslated region (UTR) identified two regions (-608 to -388 and -387 to -186) responsible for periodic accumulation of the mRNA. Deletion of one or the other of these sequences had no effect on periodic expression of the mRNA, while deletion of both regions resulted in constitutive expression of the mRNA throughout the cell cycle. Subcloning of these sequences into the 5' UTR of a construct lacking both regions of the TOP2 5' UTR has shown that an octamer consensus sequence present in the 5' UTR of the TOP2, RPA1, and DHFR-TS mRNAs is required for normal cycling of the TOP2 mRNA. Mutation of the consensus octamer sequence in the TOP2 5' UTR in a plasmid construct containing only a single consensus octamer and that shows normal cycling of the plasmid-encoded TOP2 mRNA resulted in substantial reduction of the cycling of the mRNA level. These results imply a negative regulation of TOP2 mRNA during the cell cycle by a mechanism involving redundant elements containing one or more copies of a conserved octamer sequence within the 5' UTR of TOP2 mRNA. PMID:8943327

Sequences within the 5' untranslated region regulate the levels of a kinetoplast DNA topoisomerase mRNA during the cell cycle.

PubMed

Pasion, S G; Hines, J C; Ou, X; Mahmood, R; Ray, D S

1996-12-01

Gene expression in trypanosomatids appears to be regulated largely at the posttranscriptional level and involves maturation of mRNA precursors by trans splicing of a 39-nucleotide miniexon sequence to the 5' end of the mRNA and cleavage and polyadenylation at the 3' end of the mRNA. To initiate the identification of sequences involved in the periodic expression of DNA replication genes in trypanosomatids, we have mapped splice acceptor sites in the 5' flanking region of the TOP2 gene, which encodes the kinetoplast DNA topoisomerase, and have carried out deletion analysis of this region on a plasmid-encoded TOP2 gene. Block deletions within the 5' untranslated region (UTR) identified two regions (-608 to -388 and -387 to -186) responsible for periodic accumulation of the mRNA. Deletion of one or the other of these sequences had no effect on periodic expression of the mRNA, while deletion of both regions resulted in constitutive expression of the mRNA throughout the cell cycle. Subcloning of these sequences into the 5' UTR of a construct lacking both regions of the TOP2 5' UTR has shown that an octamer consensus sequence present in the 5' UTR of the TOP2, RPA1, and DHFR-TS mRNAs is required for normal cycling of the TOP2 mRNA. Mutation of the consensus octamer sequence in the TOP2 5' UTR in a plasmid construct containing only a single consensus octamer and that shows normal cycling of the plasmid-encoded TOP2 mRNA resulted in substantial reduction of the cycling of the mRNA level. These results imply a negative regulation of TOP2 mRNA during the cell cycle by a mechanism involving redundant elements containing one or more copies of a conserved octamer sequence within the 5' UTR of TOP2 mRNA.

Experimental study of microstructure changes due to low cycle fatigue of a steel nanocrystallised by Surface Mechanical Attrition Treatment (SMAT)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun, Z.

Electron Backscatter Diffraction technique is used to characterize the microstructure of 316L steel generated by Surface Mechanical Attrition Treatment (SMAT) before and after low cycle fatigue tests. A grain size gradient is generated from the top surface to the interior of the samples after SMAT so that three main regions can be distinguished below the treated surface: (i) the ultra-fine grain area within 5 μm under the top surface with preferably oriented grains, (ii) the intermediate area where the original grains are partially transformed, and (iii) the edge periphery area where the original grains are just mechanically deformed with themore » presence of plastic slips. Fatigue tests show that cyclic loading does not change the grain orientation spread and does not activate any plastic slip in the ultra-fine grain top surface area induced by SMAT. On the opposite, in the plastically SMAT affected region including the intermediate area and the edge periphery area, new slip systems are activated by low cycle fatigue while the grain orientation spread is increased. These results represent a first very interesting step towards the characterization and understanding of mechanical mechanisms involved during the fatigue of a grain size gradient material. - Highlights: •LCF tests are carried out on specimens processed by SMAT. •EBSD is used to investigate microstructural changes induced by LCF. •A grain size gradient is generated by SMAT from surface to the bulk of the fatigue samples. •New slip systems are activated by LCF and GOS is increased in plastically deformed region. •However, these phenomena are not observed in the top surface ultra-fine grain area.« less

Levels of the E2 interacting protein TopBP1 modulate papillomavirus maintenance stage replication

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kanginakudru, Sriramana, E-mail: skangina@iu.edu; DeSmet, Marsha, E-mail: mdesmet@iupui.edu; Thomas, Yanique, E-mail: ysthomas@umail.iu.edu

2015-04-15

The evolutionarily conserved DNA topoisomerase II beta-binding protein 1 (TopBP1) functions in DNA replication, DNA damage response, and cell survival. We analyzed the role of TopBP1 in human and bovine papillomavirus genome replication. Consistent with prior reports, TopBP1 co-localized in discrete nuclear foci and was in complex with papillomavirus E2 protein. Similar to E2, TopBP1 is recruited to the region of the viral origin of replication during G1/S and early S phase. TopBP1 knockdown increased, while over-expression decreased transient virus replication, without affecting cell cycle. Similarly, using cell lines harboring HPV-16 or HPV-31 genome, TopBP1 knockdown increased while over-expression reducedmore » viral copy number relative to genomic DNA. We propose a model in which TopBP1 serves dual roles in viral replication: it is essential for initiation of replication yet it restricts viral copy number. - Highlights: • Protein interaction study confirmed In-situ interaction between TopBP1 and E2. • TopBP1 present at papillomavirus ori in G1/S and early S phase of cell cycle. • TopBP1 knockdown increased, over-expression reduced virus replication. • TopBP1 protein level change did not influence cell survival or cell cycle. • TopBP1 displaced from papillomavirus ori after initiation of replication.« less

Implications of near-term coal power plant retirement for SO2 and NOX and life cycle GHG emissions.

PubMed

Venkatesh, Aranya; Jaramillo, Paulina; Griffin, W Michael; Matthews, H Scott

2012-09-18

Regulations monitoring SO(2), NO(X), mercury, and other metal emissions in the U.S. will likely result in coal plant retirement in the near-term. Life cycle assessment studies have previously estimated the environmental benefits of displacing coal with natural gas for electricity generation, by comparing systems that consist of individual natural gas and coal power plants. However, such system comparisons may not be appropriate to analyze impacts of coal plant retirement in existing power fleets. To meet this limitation, simplified economic dispatch models for PJM, MISO, and ERCOT regions are developed in this study to examine changes in regional power plant dispatch that occur when coal power plants are retired. These models estimate the order in which existing power plants are dispatched to meet electricity demand based on short-run marginal costs, with cheaper plants being dispatched first. Five scenarios of coal plant retirement are considered: retiring top CO(2) emitters, top NO(X) emitters, top SO(2) emitters, small and inefficient plants, and old and inefficient plants. Changes in fuel use, life cycle greenhouse gas emissions (including uncertainty), and SO(2) and NO(X) emissions are estimated. Life cycle GHG emissions were found to decrease by less than 4% in almost all scenarios modeled. In addition, changes in marginal damage costs due to SO(2), and NO(X) emissions are estimated using the county level marginal damage costs reported in the Air Pollution Emissions Experiments and Policy (APEEP) model, which are a proxy for measuring regional impacts of SO(2) and NO(X) emissions. Results suggest that location specific parameters should be considered within environmental policy frameworks targeting coal plant retirement, to account for regional variability in the benefits of reducing the impact of SO(2) and NO(X) emissions.

How interactions between top-down and bottom-up controls on carbon cycling affect fluxes within and from lakes

NASA Astrophysics Data System (ADS)

Sadro, S.; Piovia-Scott, J.; Nelson, C.; Sickman, J. O.; Knapp, R.

2017-12-01

While the role of inland waters in global carbon cycling has grown clearer in recent decades, the extent to which top-down and bottom-up mechanisms interact to regulate dynamics at the catchment scale is not well understood. The degree to which lakes process, export, or store terrestrial carbon is influenced by hydrological variability, variation in the magnitude of terrestrial organic matter (t-OM) entering a system, the efficiency with which such material is metabolized by bacterioplankton, the extent to which it is incorporated into secondary consumer biomass, and by the effects of food-web structure, such as the presence or absence of top predators. However, how these processes interact to mediate carbon fluxes between terrestrial, aquatic, and atmospheric reservoirs remains unclear. We develop a conceptual model that explores how interactions among these factors ultimately affects carbon dynamics using data from lakes located in the Sierra Nevada mountains of California. The Sierra are an excellent system for studies of carbon cycling because elevation-induced landscape gradients in soil development and vegetation cover provide large natural variation in terrestrial inputs to lakes, while variation in confounding factors such as lake morphometry or trophic state is comparatively small. Dissolved organic carbon concentrations increase 100 fold in lakes spanning the alpine to montane elevation gradient found in the Sierra, and fluorescence characteristics reflect an increasingly terrestrial signature with decreasing elevation. Bacterioplankton make up a large proportion of total ecosystem metabolism in these systems, and their metabolic efficiency is tightly coupled to the composition of dissolved organic matter. Stable isotope food web data (δ13C, Δ14C, and δ2H) and measurements of pCO2 from lakes indicate the magnitude of allochthony, rates if carbon cycling, and ecosystem heterotrophy all increase with the increasingly terrestrial signature of dissolved organic matter. However, the role of food web structure in mediating these dynamics remains unclear.

Advanced regenerative absorption refrigeration cycles

DOEpatents

Dao, Kim

1990-01-01

Multi-effect regenerative absorption cycles which provide a high coefficient of performance (COP) at relatively high input temperatures. An absorber-coupled double-effect regenerative cycle (ADR cycle) (10) is provided having a single-effect absorption cycle (SEA cycle) (11) as a topping subcycle and a single-effect regenerative absorption cycle (1R cycle) (12) as a bottoming subcycle. The SEA cycle (11) includes a boiler (13), a condenser (21), an expansion device (28), an evaporator (31), and an absorber (40), all operatively connected together. The 1R cycle (12) includes a multistage boiler (48), a multi-stage resorber (51), a multisection regenerator (49) and also uses the condenser (21), expansion device (28) and evaporator (31) of the SEA topping subcycle (11), all operatively connected together. External heat is applied to the SEA boiler (13) for operation up to about 500 degrees F., with most of the high pressure vapor going to the condenser (21) and evaporator (31) being generated by the regenerator (49). The substantially adiabatic and isothermal functioning of the SER subcycle (12) provides a high COP. For higher input temperatures of up to 700 degrees F., another SEA cycle (111) is used as a topping subcycle, with the absorber (140) of the topping subcycle being heat coupled to the boiler (13) of an ADR cycle (10). The 1R cycle (12) itself is an improvement in that all resorber stages (50b-f) have a portion of their output pumped to boiling conduits (71a-f) through the regenerator (49), which conduits are connected to and at the same pressure as the highest pressure stage (48a) of the 1R multistage boiler (48).

Bond Coat Engineering Influence on the Evolution of the Microstructure, Bond Strength, and Failure of TBCs Subjected to Thermal Cycling

NASA Astrophysics Data System (ADS)

Lima, R. S.; Nagy, D.; Marple, B. R.

2015-01-01

Different types of thermal spray systems, including HVOF (JP5000 and DJ2600-hybrid), APS (F4-MB and Axial III), and LPPS (Oerlikon Metco system) were employed to spray CoNiCrAlY bond coats (BCs) onto Inconel 625 substrates. The chemical composition of the BC powder was the same in all cases; however, the particle size distribution of the powder employed with each torch was that specifically recommended for the torch. For optimization purposes, these BCs were screened based on initial evaluations of roughness, porosity, residual stress, relative oxidation, and isothermal TGO growth. A single type of standard YSZ top coat was deposited via APS (F4MB) on all the optimized BCs. The TBCs were thermally cycled by employing a furnace cycle test (FCT) (1080 °C-1 h—followed by forced air cooling). Samples were submitted to 10, 100, 400, and 1400 cycles as well as being cycled to failure. The behavior of the microstructures, bond strength values (ASTM 633), and the TGO evolution of these TBCs, were investigated for the as-sprayed and thermally cycled samples. During FCT, the TBCs found to be both the best and poorest performing and had their BCs deposited via HVOF. The results showed that engineering low-oxidized BCs does not necessarily lead to an optimal TBC performance. Moreover, the bond strength values decrease significantly only when the TBC is about to fail (top coat spall off) and the as-sprayed bond strength values cannot be used as an indicator of TBC performance.

Moving Up the CMMI Capability and Maturity Levels Using Simulation

DTIC Science & Technology

2008-01-01

Alternative Process Tools, Including NPV and ROI 6 Figure 3: Top-Level View of the Full Life-Cycle Version of the IEEE 12207 PSIM, Including IV&V Layer 19...Figure 4: Screenshot of the Incremental Version Model 19 Figure 5: IEEE 12207 PSIM Showing the Top-Level Life-Cycle Phases 22 Figure 6: IEEE 12207 ...Software Detailed Design for the IEEE 12207 Life- Cycle Process 24 Figure 8: Incremental Life Cycle PSIM Configured for a Specific Project Using SEPG

Triple effect absorption cycles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Erickson, D.C.; Potnis, S.V.; Tang, J.

1996-12-31

Triple effect absorption chillers can achieve 50% COP improvement over double-effect systems. However, to translate this potential into cost-effective hardware, the most promising embodiments must be identified. In this study, 12 generic triple effect cycles and 76 possible hermetic loop arrangements of those 12 generic cycles were identified. The generic triple effect cycles were screened based on their pressure and solubility field requirements, generic COPs, risk involved in the component design, and number of components in a high corrosive environment. This screening identified four promising arrangements: Alkitrate Topping cycle, Pressure Staged Envelope cycle, High Pressure Overlap cycle, and Dual Loopmore » cycle. All of these arrangements have a very high COP ({approximately} 1.8), however the development risk and cost involved is different for each arrangement. Therefore, the selection of a particular arrangement will depend upon the specific situation under consideration.« less

Advanced tracking systems design and analysis

NASA Technical Reports Server (NTRS)

Potash, R.; Floyd, L.; Jacobsen, A.; Cunningham, K.; Kapoor, A.; Kwadrat, C.; Radel, J.; Mccarthy, J.

1989-01-01

The results of an assessment of several types of high-accuracy tracking systems proposed to track the spacecraft in the National Aeronautics and Space Administration (NASA) Advanced Tracking and Data Relay Satellite System (ATDRSS) are summarized. Tracking systems based on the use of interferometry and ranging are investigated. For each system, the top-level system design and operations concept are provided. A comparative system assessment is presented in terms of orbit determination performance, ATDRSS impacts, life-cycle cost, and technological risk.

Monthly Covariability of Amazonian Convective Cloud Properties and Radiative Diurnal Cycle

NASA Technical Reports Server (NTRS)

Dodson, J. Brant; Taylor, Patrick C.

2016-01-01

The diurnal cycle of convective clouds greatly influences the top-of-atmosphere radiative energy balance in convectively active regions of Earth, through both direct presence and the production of anvil and stratiform clouds. CloudSat and CERES data are used to further examine these connections by determining the sensitivity of monthly anomalies in the radiative diurnal cycle to monthly anomalies in multiple cloud variables. During months with positive anomalies in convective frequency, the longwave diurnal cycle is shifted and skewed earlier in the day by the increased longwave cloud forcing during the afternoon from mature deep convective cores and associated anvils. This is consistent with previous studies using reanalysis data to characterize anomalous convective instability. Contrary to this, months with positive anomalies in convective cloud top height (commonly associated with more intense convection) shifts the longwave diurnal cycle later in the day. The contrary results are likely an effect of the inverse relationships between cloud top height and frequency. The albedo diurnal cycle yields inconsistent results when using different cloud variables.

Potassium topping cycles for stationary power. [conceptual analysis

NASA Technical Reports Server (NTRS)

Rossbach, R. J.

1975-01-01

A design study was made of the potassium topping cycle powerplant for central station use. Initially, powerplant performance and economics were studied parametrically by using an existing steam plant as the bottom part of the cycle. Two distinct powerplants were identified which had good thermodynamic and economic performance. Conceptual designs were made of these two powerplants in the 1200 MWe size, and capital and operating costs were estimated for these powerplants. A technical evaluation of these plants was made including conservation of fuel resources, environmental impact, technology status, and degree of development risk. It is concluded that the potassium topping cycle could have a significant impact on national goals such as air and water pollution control and conservation of natural resources because of its higher energy conversion efficiency.

Three-dimensional knee joint kinematics during golf swing and stationary cycling after total knee arthroplasty.

PubMed

Hamai, Satoshi; Miura, Hiromasa; Higaki, Hidehiko; Shimoto, Takeshi; Matsuda, Shuichi; Okazaki, Ken; Iwamoto, Yukihide

2008-12-01

The expectation of returning to sports activities after total knee arthroplasty (TKA) has become more important to patients than ever. To our knowledge, no studies have been published evaluating the three-dimensional knee joint kinematics during sports activity after TKA. Continuous X-ray images of the golf swing and stationary cycling were taken using a large flat panel detector for four and eight post-arthroplasty knees, respectively. The implant flexion and axial rotation angles were determined using a radiographic-based, image-matching technique. Both the golf swing from the set-up position to the top of the backswing, and the stationary cycling from the top position of the crank to the bottom position of the crank, produced progressive axial rotational motions (p = 0.73). However, the golf swing from the top of the backswing to the end of the follow-through produced significantly larger magnitudes of rotational motions in comparison to stationary cycling (p < 0.01). Excessive internal-external rotations generated from the top of the backswing to the end of the follow-through could contribute to accelerated polyethylene wear. However, gradual rotational movements were consistently demonstrated during the stationary cycling. Therefore, stationary cycling is recommended rather than playing golf for patients following a TKA who wish to remain physically active.

High efficiency Dual-Cycle Conversion System using Kr-85.

PubMed

Prelas, Mark A; Tchouaso, Modeste Tchakoua

2018-04-26

This paper discusses the use of one of the safest isotopes known isotopes, Kr-85, as a candidate fuel source for deep space missions. This isotope comes from 0.286% of fission events. There is a vast quantity of Kr-85 stored in spent fuel and it is continually being produced by nuclear reactors. In using Kr-85 with a novel Dual Cycle Conversion System (DCCS) it is feasible to boost the system efficiency from 26% to 45% over a single cycle device while only increasing the system mass by less than 1%. The Kr-85 isotope is the ideal fuel for a Photon Intermediate Direct Energy Conversion (PIDEC) system. PIDEC is an excellent choice for the top cycle in a DCCS. In the top cycle, ionization and excitation of the Kr-85:Cl gas mixture (99% Kr and 1% Cl) from beta particles creates KrCl* excimer photons which are efficiently absorbed by diamond photovoltaic cells on the walls of the pressure vessels. The benefit of using the DCCS is that Kr-85 is capable of operating at high temperatures in the primary cycle and the residual heat can then be converted into electrical power in the bottom cycle which uses a Stirling Engine. The design of the DCCS begins with a spherical pressure vessel of radius 13.7 cm with 3.7 cm thick walls and is filled with a Kr-85:Cl gas mixture. The inner wall has diamond photovoltaic cells attached to it and there is a sapphire window between the diamond photovoltaic cells and the Kr-85:Cl gas mixture which shields the photovoltaic cells from beta particles. The DCCS without a gamma ray shield has specific power of 6.49 W/kg. A removable 6 cm thick tungsten shield is used to safely limit the radiation exposure levels of personnel. A shadow shield remains in the payload to protect the radiation sensitive components in the flight package. The estimated specific power of the unoptimized system design in this paper is about 2.33 W/kg. The specific power of an optimized system should be higher. The Kr-85 isotope is relatively safe because it will disperse quickly in case of an accident and if it enters the lungs there is no significant biological half-life. Copyright © 2018 Elsevier Ltd. All rights reserved.

Performance Benefits for Wave Rotor-Topped Gas Turbine Engines

NASA Technical Reports Server (NTRS)

Jones, Scott M.; Welch, Gerard E.

1996-01-01

The benefits of wave rotor-topping in turboshaft engines, subsonic high-bypass turbofan engines, auxiliary power units, and ground power units are evaluated. The thermodynamic cycle performance is modeled using a one-dimensional steady-state code; wave rotor performance is modeled using one-dimensional design/analysis codes. Design and off-design engine performance is calculated for baseline engines and wave rotor-topped engines, where the wave rotor acts as a high pressure spool. The wave rotor-enhanced engines are shown to have benefits in specific power and specific fuel flow over the baseline engines without increasing turbine inlet temperature. The off-design steady-state behavior of a wave rotor-topped engine is shown to be similar to a conventional engine. Mission studies are performed to quantify aircraft performance benefits for various wave rotor cycle and weight parameters. Gas turbine engine cycles most likely to benefit from wave rotor-topping are identified. Issues of practical integration and the corresponding technical challenges with various engine types are discussed.

Tailoring Enterprise Systems Engineering Policy for Project Scale and Complexity

NASA Technical Reports Server (NTRS)

Cox, Renee I.; Thomas, L. Dale

2014-01-01

Space systems are characterized by varying degrees of scale and complexity. Accordingly, cost-effective implementation of systems engineering also varies depending on scale and complexity. Recognizing that systems engineering and integration happen everywhere and at all levels of a given system and that the life cycle is an integrated process necessary to mature a design, the National Aeronautic and Space Administration's (NASA's) Marshall Space Flight Center (MSFC) has developed a suite of customized implementation approaches based on project scale and complexity. While it may be argued that a top-level system engineering process is common to and indeed desirable across an enterprise for all space systems, implementation of that top-level process and the associated products developed as a result differ from system to system. The implementation approaches used for developing a scientific instrument necessarily differ from those used for a space station. .

Energy Conversion Alternatives Study (ECAS), Westinghouse phase 1. Volume 9: Closed-cycle MHD. [energy conversion efficiency of electric power plants using magnetohydrodynamics

NASA Technical Reports Server (NTRS)

Tsu, T. C.

1976-01-01

A closed-cycle MHD system for an electric power plant was studied. It consists of 3 interlocking loops, an external heating loop, a closed-cycle cesium seeded argon nonequilibrium ionization MHD loop, and a steam bottomer. A MHD duct maximum temperature of 2366 K (3800 F), a pressure of 0.939 MPa (9.27 atm) and a Mach number of 0.9 are found to give a topping cycle efficiency of 59.3%; however when combined with an integrated gasifier and optimistic steam bottomer the coal to bus bar efficiency drops to 45.5%. A 1978 K (3100 F) cycle has an efficiency of 55.1% and a power plant efficiency of 42.2%. The high cost of the external heating loop components results in a cost of electricity of 21.41 mills/MJ (77.07 mills/kWh) for the high temperature system and 19.0 mills/MJ (68.5 mills/kWh) for the lower temperature system. It is, therefore, thought that this cycle may be more applicable to internally heated systems such as some futuristic high temperature gas cooled reactor.

Simulated performance of biomass gasification based combined power and refrigeration plant for community scale application

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chattopadhyay, S., E-mail: suman.mech09@gmail.com; Mondal, P., E-mail: mondal.pradip87@gmail.com; Ghosh, S., E-mail: sudipghosh.becollege@gmail.com

Thermal performance analysis and sizing of a biomass gasification based combined power and refrigeration plant (CPR) is reported in this study. The plant is capable of producing 100 kWe of electrical output while simultaneously producing a refrigeration effect, varying from 28-68 ton of refrigeration (TR). The topping gas turbine cycle is an indirectly heated all-air cycle. A combustor heat exchanger duplex (CHX) unit burns producer gas and transfer heat to air. This arrangement avoids complex gas cleaning requirements for the biomass-derived producer gas. The exhaust air of the topping GT is utilized to run a bottoming ammonia absorption refrigeration (AAR)more » cycle via a heat recovery steam generator (HRSG), steam produced in the HRSG supplying heat to the generator of the refrigeration cycle. Effects of major operating parameters like topping cycle pressure ratio (r{sub p}) and turbine inlet temperature (TIT) on the energetic performance of the plant are studied. Energetic performance of the plant is evaluated via energy efficiency, required biomass consumption and fuel energy savings ratio (FESR). The FESR calculation method is significant for indicating the savings in fuel of a combined power and process heat plant instead of separate plants for power and process heat. The study reveals that, topping cycle attains maximum power efficiency of 30%in pressure ratio range of 8-10. Up to a certain value of pressure ratio the required air flow rate through the GT unit decreases with increase in pressure ratio and then increases with further increase in pressure ratio. The capacity of refrigeration of the AAR unit initially decreases up to a certain value of topping GT cycle pressure ratio and then increases with further increase in pressure ratio. The FESR is found to be maximized at a pressure ratio of 9 (when TIT=1100°C), the maximum value being 53%. The FESR is higher for higher TIT. The heat exchanger sizing is also influenced by the topping cycle pressure ratio and GT-TIT.« less

Design of the NASA Lewis 4-Port Wave Rotor Experiment

NASA Technical Reports Server (NTRS)

Wilson, Jack

1997-01-01

Pressure exchange wave rotors, used in a topping stage, are currently being considered as a possible means of increasing the specific power, and reducing the specific fuel consumption of gas turbine engines. Despite this interest, there is very little information on the performance of a wave rotor operating on the cycle (i.e., set of waves) appropriate for use in a topping stage. One such cycle, which has the advantage of being relatively easy to incorporate into an engine, is the four-port cycle. Consequently, an experiment to measure the performance of a four-port wave rotor for temperature ratios relevant to application as a topping cycle for a gas turbine engine has been designed and built at NASA Lewis. The design of the wave rotor is described, together with the constraints on the experiment.

Jet engine performance enhancement through use of a wave-rotor topping cycle

NASA Technical Reports Server (NTRS)

Wilson, Jack; Paxson, Daniel E.

1993-01-01

A simple model is used to calculate the thermal efficiency and specific power of simple jet engines and jet engines with a wave-rotor topping cycle. The performance of the wave rotor is based on measurements from a previous experiment. Applied to the case of an aircraft flying at Mach 0.8, the calculations show that an engine with a wave rotor topping cycle may have gains in thermal efficiency of approximately 1 to 2 percent and gains in specific power of approximately 10 to 16 percent over a simple jet engine with the same overall compression ratio. Even greater gains are possible if the wave rotor's performance can be improved.

A technical analysis for cogeneration systems with potential applications in twelve California industrial plants. [energy saving heat-electricity utility systems

NASA Technical Reports Server (NTRS)

Moretti, V. C.; Davis, H. S.; Slonski, M. L.

1978-01-01

In a study sponsored by the State of California Energy Resources Conservation and Development Commission, 12 industrial plants in five utility districts were surveyed to assess the potential applications of the cogeneration of heat and electricity in California industry. Thermodynamic calculations were made for each plant in determining the energy required to meet the existing electrical and steam demands. The present systems were then compared to conceptual cogeneration systems specified for each plant. Overall energy savings were determined for the cogeneration applications. Steam and gas turbine topping cycle systems were considered as well as bottoming cycle systems. Types of industries studied were: pulp and paper, timber, cement, petroleum refining, enhanced oil recovery, foods processing, steel and glass

Computer Modeling and Optimization of OBOGS with Contaminants

DTIC Science & Technology

1988-02-15

respect to system parameters such as cycle time and bed and valve dimensions. _-- 20. DISTRIBUTION /AVAILABILITY OF ABSTRACT 21. ABSTRACT SECURITY...schematic (Solenoid valves are numbered 1 to 4 from the top) ..................................................... 46 Figure 12: Dual bed apparatus...most basic continuous PSA system is shown in Figure 1. Here a switching valve imposes supply pressure on Bed #1 and exhaust pressure on Bed #2. As the

Mortality and business cycles by level of development: evidence from Mexico.

PubMed

Gonzalez, Fidel; Quast, Troy

2010-12-01

We investigate the relationship between mortality and business cycles within Mexico, where development varies significantly. We exploit this variation by separately analyzing the top ten and bottom ten developed states for the period 1993-2004. We find that while overall mortality is procyclical nationally and in the top ten states, it is countercyclical in the bottom ten. Further, we show that in the top ten states mortality due to non communicable conditions is procyclical, while in the bottom ten mortality due to non communicable conditions and infectious and parasitic diseases are countercyclical. Our results suggest that the relationship between mortality and business cycles may vary by level of development. Copyright © 2010 Elsevier Ltd. All rights reserved.

Performance analysis of a bio-gasification based combined cycle power plant employing indirectly heated humid air turbine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mukherjee, S., E-mail: sankha.deepp@gmail.com; Mondal, P., E-mail: mondal.pradip87@gmail.com; Ghosh, S., E-mail: sudipghosh.becollege@gmail.com

Rapid depletion of fossil fuel has forced mankind to look into alternative fuel resources. In this context, biomass based power generation employing gas turbine appears to be a popular choice. Bio-gasification based combined cycle provides a feasible solution as far as grid-independent power generation is concerned for rural electrification projects. Indirectly heated gas turbine cycles are promising alternatives as they avoid downstream gas cleaning systems. Advanced thermodynamic cycles have become an interesting area of study to improve plant efficiency. Water injected system is one of the most attractive options in this field of applications. This paper presents a theoretical modelmore » of a biomass gasification based combined cycle that employs an indirectly heated humid air turbine (HAT) in the topping cycle. Maximum overall electrical efficiency is found to be around 41%. Gas turbine specific air consumption by mass is minimum when pressure ratio is 6. The study reveals that, incorporation of the humidification process helps to improve the overall performance of the plant.« less

Modeling of heat and mass transfer processes for the gap-lyophilization system using the mannitol-trehalose-NaCl formulation.

PubMed

Kuu, Wei Y; Doty, Mark J; Nisipeanu, Eugen; Rebbeck, Christine L; Cho, Yong K; Smit, Mark H

2014-09-01

Gap freezing (GF) is a new concept that was developed to reduce the primary drying time using an alternative freezing process. The purpose of this investigation was to determine the gap-tray heat transfer coefficient, Kgtr , and to investigate the effect of gap lyophilization on cycle reduction of a mannitol-trehalose-NaCl (MTN) formulation. The values of Kgtr were measured using the product temperature profiles in three different configurations: (1) shelf freezing followed by shelf drying (denoted as SF-SD), (2) GF followed by SD (denoted as GF-SD), and (3) GF followed by gap drying (denoted as GF-GD). For the lyophilization cycle using shelf drying (SF-SD), 80% of the heat transferred during primary drying was from the bottom shelf to the vial, versus 20% via radiation from the top shelf. For the lyophilization cycle using gap drying (GF-GD), only 37% of the heat transferred during primary drying was from the bottom shelf to the vial versus 63% via radiation from the top shelf. Furthermore, GF in conjunction with annealing significantly reduces the dry layer resistance of the MTN formulation, which is the opposite of what was observed with a conventional freezing cycle. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.

MHD conversion of solar energy. [space electric power system

NASA Technical Reports Server (NTRS)

Lau, C. V.; Decher, R.

1978-01-01

Low temperature plasmas wherein an alkali metal vapor is a component are uniquely suited to simultaneously absorb solar radiation by coupling to the resonance lines and produce electrical power by the MHD interaction. This work is an examination of the possibility of developing space power systems which take advantage of concentrated solar power to produce electricity. It is shown that efficient cycles in which expansion work takes place at nearly constant top cycle temperature can be devised. The power density of the solar MHD generator is lower than that of conventional MHD generators because of the relatively high seed concentration required for radiation absorption and the lower flow velocity permitted to avoid total pressure losses due to heating.

TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint

PubMed Central

Cescutti, Rachele; Negrini, Simona; Kohzaki, Masaoki; Halazonetis, Thanos D

2010-01-01

TopBP1 is a checkpoint protein that colocalizes with ATR at sites of DNA replication stress. In this study, we show that TopBP1 also colocalizes with 53BP1 at sites of DNA double-strand breaks (DSBs), but only in the G1-phase of the cell cycle. Recruitment of TopBP1 to sites of DNA replication stress was dependent on BRCT domains 1–2 and 7–8, whereas recruitment to sites of DNA DSBs was dependent on BRCT domains 1–2 and 4–5. The BRCT domains 4–5 interacted with 53BP1 and recruitment of TopBP1 to sites of DNA DSBs in G1 was dependent on 53BP1. As TopBP1 contains a domain important for ATR activation, we examined whether it contributes to the G1 cell cycle checkpoint. By monitoring the entry of irradiated G1 cells into S-phase, we observed a checkpoint defect after siRNA-mediated depletion of TopBP1, 53BP1 or ATM. Thus, TopBP1 may mediate the checkpoint function of 53BP1 in G1. PMID:20871591

TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint.

PubMed

Cescutti, Rachele; Negrini, Simona; Kohzaki, Masaoki; Halazonetis, Thanos D

2010-11-03

TopBP1 is a checkpoint protein that colocalizes with ATR at sites of DNA replication stress. In this study, we show that TopBP1 also colocalizes with 53BP1 at sites of DNA double-strand breaks (DSBs), but only in the G1-phase of the cell cycle. Recruitment of TopBP1 to sites of DNA replication stress was dependent on BRCT domains 1-2 and 7-8, whereas recruitment to sites of DNA DSBs was dependent on BRCT domains 1-2 and 4-5. The BRCT domains 4-5 interacted with 53BP1 and recruitment of TopBP1 to sites of DNA DSBs in G1 was dependent on 53BP1. As TopBP1 contains a domain important for ATR activation, we examined whether it contributes to the G1 cell cycle checkpoint. By monitoring the entry of irradiated G1 cells into S-phase, we observed a checkpoint defect after siRNA-mediated depletion of TopBP1, 53BP1 or ATM. Thus, TopBP1 may mediate the checkpoint function of 53BP1 in G1.

Sex difference in top performers from Ironman to double deca iron ultra-triathlon

PubMed Central

Knechtle, Beat; Zingg, Matthias A; Rosemann, Thomas; Rüst, Christoph A

2014-01-01

This study investigated changes in performance and sex difference in top performers for ultra-triathlon races held between 1978 and 2013 from Ironman (3.8 km swim, 180 km cycle, and 42 km run) to double deca iron ultra-triathlon distance (76 km swim, 3,600 km cycle, and 844 km run). The fastest men ever were faster than the fastest women ever for split and overall race times, with the exception of the swimming split in the quintuple iron ultra-triathlon (19 km swim, 900 km cycle, and 210.1 km run). Correlation analyses showed an increase in sex difference with increasing length of race distance for swimming (r2=0.67, P=0.023), running (r2=0.77, P=0.009), and overall race time (r2=0.77, P=0.0087), but not for cycling (r2=0.26, P=0.23). For the annual top performers, split and overall race times decreased across years nonlinearly in female and male Ironman triathletes. For longer distances, cycling split times decreased linearly in male triple iron ultra-triathletes, and running split times decreased linearly in male double iron ultra-triathletes but increased linearly in female triple and quintuple iron ultra-triathletes. Overall race times increased nonlinearly in female triple and male quintuple iron ultra-triathletes. The sex difference decreased nonlinearly in swimming, running, and overall race time in Ironman triathletes but increased linearly in cycling and running and nonlinearly in overall race time in triple iron ultra-triathletes. These findings suggest that women reduced the sex difference nonlinearly in shorter ultra-triathlon distances (ie, Ironman), but for longer distances than the Ironman, the sex difference increased or remained unchanged across years. It seems very unlikely that female top performers will ever outrun male top performers in ultratriathlons. The nonlinear change in speed and sex difference in Ironman triathlon suggests that female and male Ironman triathletes have reached their limits in performance. PMID:25114605

Development of standardized air-blown coal gasifier/gas turbine concepts for future electric power systems, Volume 4. Appendix C: Design and performance of standardized fixed bed air-blown gasifier IGCC systems for future electric power generation: Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-02-01

This appendix is a compilation of work done to predict overall cycle performance from gasifier to generator terminals. A spreadsheet has been generated for each case to show flows within a cycle. The spreadsheet shows gaseous or solid composition of flow, temperature of flow, quantity of flow, and heat heat content of flow. Prediction of steam and gas turbine performance was obtained by the computer program GTPro. Outputs of all runs for each combined cycle reviewed has been added to this appendix. A process schematic displaying all flows predicted through GTPro and the spreadsheet is also added to this appendix.more » The numbered bubbles on the schematic correspond to columns on the top headings of the spreadsheet.« less

Building biological foundries for next-generation synthetic biology.

PubMed

Chao, Ran; Yuan, YongBo; Zhao, HuiMin

2015-07-01

Synthetic biology is an interdisciplinary field that takes top-down approaches to understand and engineer biological systems through design-build-test cycles. A number of advances in this relatively young field have greatly accelerated such engineering cycles. Specifically, various innovative tools were developed for in silico biosystems design, DNA de novo synthesis and assembly, construct verification, as well as metabolite analysis, which have laid a solid foundation for building biological foundries for rapid prototyping of improved or novel biosystems. This review summarizes the state-of-the-art technologies for synthetic biology and discusses the challenges to establish such biological foundries.

Heat Exchanger Design in Combined Cycle Engines

NASA Astrophysics Data System (ADS)

Webber, H.; Feast, S.; Bond, A.

Combined cycle engines employing both pre-cooled air-breathing and rocket modes of operation are the most promising propulsion system for achieving single stage to orbit vehicles. The air-breathing phase is purely for augmentation of the mission velocity required in the rocket phase and as such must be mass effective, re-using the components of the rocket cycle, whilst achieving adequate specific impulse. This paper explains how the unique demands placed on the air-breathing cycle results in the need for sophisticated thermodynamics and the use of a series of different heat exchangers to enable precooling and high pressure ratio compression of the air for delivery to the rocket combustion chambers. These major heat exchanger roles are; extracting heat from incoming air in the precooler, topping up cycle flow temperatures to maintain constant turbine operating conditions and extracting rejected heat from the power cycle via regenerator loops for thermal capacity matching. The design solutions of these heat exchangers are discussed.

Highly efficient 6-stroke engine cycle with water injection

DOEpatents

Szybist, James P; Conklin, James C

2012-10-23

A six-stroke engine cycle having improved efficiency. Heat is recovered from the engine combustion gases by using a 6-stroke engine cycle in which combustion gases are partially vented proximate the bottom-dead-center position of the fourth stroke cycle, and water is injected proximate the top-dead-center position of the fourth stroke cycle.

Power Generation Potential and Cost of a Roof Top Solar PV System in Kathmandu, Nepal

NASA Astrophysics Data System (ADS)

Sanjel, N.; Zhand, A.

2017-12-01

The paper presents a comparative study of the 3 most used solar PV module technologies in Nepal, which are Si-mono-crystalline, Si-poly-crystalline and Si-amorphous. The aim of the paper is to present and discuss the recorded Global Solar Radiation, received in the Kathmandu valley by three different, Si-mono-crystalline, Si-poly-crystalline and Si-amorphous calibrated solar cell pyranometers and to propose the best-suited solar PV module technology for roof top solar PV systems inside the Kathmandu valley. Data recorded over the course of seven months, thus covering most of the seasonal meteorological conditions determining Kathmandu valley's global solar radiation reception are presented. The results indicate that the Si-amorphous pyranometer captured 1.56% more global solar radiation than the Si-mono-crystalline and 18.4% more than Si-poly-crystalline pyranometer over the course of seven months. Among the three pyranometer technologies the maximum and minimum cell temperature was measured by the Si-mono-crystalline pyranometer. Following the technical data and discussion, an economical analysis, using the versatile software tool PVSYST V5.01is used to calculate the life cycle costs of a 1kW roof top solar PV RAPS system, with battery storage, and a 1kW roof top solar PV grid connected system with no energy storage facility, through simulations, using average recorded global solar radiation data for the KTM valley and investigated market values for each solar PV module and peripheral equipment costs.

Residual Stresses Modeled in Thermal Barrier Coatings

NASA Technical Reports Server (NTRS)

Freborg, A. M.; Ferguson, B. L.; Petrus, G. J.; Brindley, W. J.

1998-01-01

Thermal barrier coating (TBC) applications continue to increase as the need for greater engine efficiency in aircraft and land-based gas turbines increases. However, durability and reliability issues limit the benefits that can be derived from TBC's. A thorough understanding of the mechanisms that cause TBC failure is a key to increasing, as well as predicting, TBC durability. Oxidation of the bond coat has been repeatedly identified as one of the major factors affecting the durability of the ceramic top coat during service. However, the mechanisms by which oxidation facilitates TBC failure are poorly understood and require further characterization. In addition, researchers have suspected that other bond coat and top coat factors might influence TBC thermal fatigue life, both separately and through interactions with the mechanism of oxidation. These other factors include the bond coat coefficient of thermal expansion, the bond coat roughness, and the creep behavior of both the ceramic and bond coat layers. Although it is difficult to design an experiment to examine these factors unambiguously, it is possible to design a computer modeling "experiment" to examine the action and interaction of these factors, as well as to determine failure drivers for TBC's. Previous computer models have examined some of these factors separately to determine their effect on coating residual stresses, but none have examined all the factors concurrently. The purpose of this research, which was performed at DCT, Inc., in contract with the NASA Lewis Research Center, was to develop an inclusive finite element model to characterize the effects of oxidation on the residual stresses within the TBC system during thermal cycling as well as to examine the interaction of oxidation with the other factors affecting TBC life. The plasma sprayed, two-layer thermal barrier coating that was modeled incorporated a superalloy substrate, a NiCrAlY bond coat, and a ZrO2-8 wt % Y2O3 ceramic top coat. We examined the effect on stress during burner rig thermal cycling of the following independent variables: creep in the bond coat and top coat, oxidation, bond coat coefficient of thermal expansion, number of thermal cycles, and interfacial roughness. All these factors were suspected of influencing TBC failure. The model showed that all the material properties studied had a significant effect on the coating's residual stresses if the interface of the bond coat was rough. Bond coat expansion, bond coat oxidation, and bond coat creep had the highest effect on coating stresses, and these were highly interactive. The model also showed that the mechanism of stress generation during thermal cycling changed with the number of thermal cycles. Bond coat and top coat creep dominated stress generation during early thermal cycles, greatly increasing delamination stresses at the peaks of the bond coat. Therefore, creep is the prime driver for delamination cracking early in life, but cracking is limited to the bond coat peak region. Oxidation of the bond coat, on the other hand, tended to dominate stress generation during later cycles by greatly increasing delamination stresses over bond coat valleys. These results indicate that oxidation is the driver for the continued cracking necessary to cause ceramic layer spallation.

Life-cycle energy production and emissions mitigation by comprehensive biogas-digestate utilization.

PubMed

Chen, Shaoqing; Chen, Bin; Song, Dan

2012-06-01

In the context of global energy shortages and climate change, developing biogas plants with links to agricultural system has become an important strategy for cleaner rural energy and renewable agriculture. In this study, a life-cycle energy and environmental assessment was performed for a biogas-digestate utilization system in China. The results suggest that biogas utilization (heating, illumination, and fuel) and comprehensive digestate reuse are of equal importance in the total energy production of the system, and they also play an important role in systemic greenhouse gas mitigation. Improvement can be achieved in both energy production and emissions mitigation when the ratio of the current three biogas utilization pathways is adjusted. Regarding digestate reuse, a tradeoff between energy and environmental performance can be obtained by focusing on the substitution for top-dressing, base fertilizers, and the application to seed soaking. Copyright © 2012 Elsevier Ltd. All rights reserved.

METHOD OF AND APPARATUS FOR WITHDRAWING LIGHT ISOTOPIC PRODUCT FROM A LIQUID THERMAL DIFFUSION PLANT

DOEpatents

Dole, M.

1959-09-22

An improved process and apparatus are described for removing enriched product from the columns of a thermal diffusion plant for separation of isotopes. In the removal cycle, light product at the top cf the diffusion columns is circulated through the column tops and a shipping cylinder connected thereto unttl the concertation of enriched product in the cylinder reaches the desired point. During the removal, circulation through the bottoms is blocked bv freezing. in the diffusion cycle, the bottom portion is unfrozen, fresh feed is distributed to the bottoms of the columns, ard heavy product is withdrawn from the bottoms, while the tops of the columns are blocked by freezing.

The Influence of Eccentricity Cycles on Exoplanet Habitability

NASA Astrophysics Data System (ADS)

Baskin, N. J. K.; Fabrycky, D. C.; Abbot, D. S.

2015-12-01

In our search for habitable exoplanets, it is important to understand how planetary habitability is influenced by orbital configurations that differ from those of the terrestrial planets in our Solar system. In particular, observational surveys have revealed the prevalence of planetary systems around binary stars. Within these systems, the gravitational influence of a companion star can induce libration in the eccentricity of the planet's orbit (referred to as Kozai Cycles) on timescales as short as thousands of years. The resulting fluctuations in stellar flux at the top of the atmosphere can potentially induce dramatic variations in surface temperatures, with direct implications for the planet's habitability prospects. We investigate this research problem using two steps. First, we utilize the MERCURY N-body integrator in order to calculate the eccentricity of a hypothetical Earth-analogue under the gravitational influence of a stellar companion. Second, we run a coupled Global Climate Model (GCM) at various stages of a cycle provided by the MERCURY runs in order to examine if the increase in insolation renders the planet uninhabitable. This work will allow us to better understand how Kozai cycles influence the boundaries of a planet's habitable zone.

Embryo quality is the main factor affecting cumulative live birth rate after elective single embryo transfer in fresh stimulation cycles.

PubMed

Niinimäki, Maarit; Veleva, Zdravka; Martikainen, Hannu

2015-11-01

The study was aimed to evaluate which factors affect the cumulative live birth rate after elective single embryo transfer in women younger than 36 years. Additionally, number of children in women with more than one delivery per ovum pick-up after fresh elective single embryo transfer and subsequent frozen embryo transfers was assessed. Retrospective cohort study analysing data of a university hospital's infertility clinic in 2001-2010. A total of 739 IVF/ICSI cycles with elective single embryo transfer were included. Analyses were made per ovum pick-up including fresh and subsequent frozen embryo transfers. Factors affecting cumulative live birth rates were examined in uni- and multivariate analyses. A secondary endpoint was the number of children born after all treatments. In the fresh cycles, the live birth rate was 29.2% and the cumulative live birth rate was 51.3%, with a twin rate of 3.4%. In the multivariate analysis, having two (odds ratio (OR) 1.73; 95% confidence interval (CI) 1.12-2.67) or ≥3 top embryos (OR 2.66; 95% CI 1.79-3.95) was associated with higher odds for live birth after fresh and frozen embryo cycles. Age, body mass index, duration of infertility, diagnosis or total gonadotropin dose were not associated with the cumulative live birth rate. In cycles with one top embryo, the cumulative live birth rate was 40.2%, whereas it was 64.1% in those with at least three top embryos. Of women who had a live birth in the fresh cycle, 20.4% had more than one child after all frozen embryo transfers. Among women with three or more top embryos after ovum pick-up, 16.1% gave birth to more than one child. The cumulative live birth rate in this age group varies from 40% to 64% and is dependent on the quality of embryos. Women with three or more top embryos have good chance of having more than one child per ovum pick-up without elevated risk of multiple pregnancies. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Top 10 revenue cycle mistakes.

PubMed

Stuller, Elizabeth

2005-01-01

Hospitals looking to gain and maintain strong revenue cycle performance should avoid common mistakes, such as not verifying insurance coverage in advance and placing sole responsibility for correct documentation on physicians.

A novel setup for wafer curvature measurement at very high heating rates.

PubMed

Islam, T; Zechner, J; Bernardoni, M; Nelhiebel, M; Pippan, R

2017-02-01

The curvature evolution of a thin film layer stack containing a top Al layer is measured during temperature cycles with very high heating rates. The temperature cycles are generated by means of programmable electrical power pulses applied to miniaturized polysilicon heater systems embedded inside a semiconductor chip and the curvature is measured by a fast wafer curvature measurement setup. Fast temperature cycles with heating duration of 100 ms are created to heat the specimen up to 270 °C providing an average heating rate of 2500 K/s. As a second approach, curvature measurement utilizing laser scanning Doppler vibrometry is also demonstrated which verifies the results obtained from the fast wafer curvature measurement setup. Film stresses calculated from the measured curvature values compare well to literature results, indicating that the new method can be used to measure curvature during fast temperature cycling.

Liquid metal magnetohydrodynamics (LMMHD) technology transfer feasibility study. Volume 1: Summary

NASA Technical Reports Server (NTRS)

Phen, R. L.; Hays, L. G.; Alper, M. E.

1973-01-01

The potential application of liquid metal magnetohydrodynamics (LMMHD) to central station utility power generation through the period to 1990 is examined. Included are: (1) a description of LMMHD and a review of its development status, (2) LMMHD preliminary design for application to central station utility power generation, (3) evaluation of LMMHD in comparison with conventional and other advanced power generation systems and (4) a technology development plan. One of the major conclusions found is that the most economic and technically feasible application of LMMHD is a topping cycle to a steam plant, taking advantage of high temperatures available but not usable by the steam cycle.

The Cloud Top Distribution and Diurnal Variation of Clouds Over East Asia: Preliminary Results From Advanced Himawari Imager

NASA Astrophysics Data System (ADS)

Chen, Dandan; Guo, Jianping; Wang, Hongqing; Li, Jian; Min, Min; Zhao, Wenhui; Yao, Dan

2018-04-01

Clouds, as one of the most uncertain factors in climate system, have been intensively studied as satellites with advanced instruments emerged in recent years. However, few studies examine the vertical distributions of cloud top and their temporal variations over East Asia based on geostationary satellite data. In this study, the vertical structures of cloud top and its diurnal variations in summer of 2016 are analyzed using the Advanced Himawari Imager/Himawari-8 cloud products. Results show that clouds occur most frequently over the southern Tibetan Plateau and the Bay of Bengal. We find a steep gradient of cloud occurrence frequency extending from southwest to northeast China and low-value centers over the eastern Pacific and the Inner Mongolia Plateau. The vertical structures of cloud top are highly dependent on latitude, in addition to the nonnegligible roles of both terrain and land-sea thermal contrast. In terms of the diurnal cycle, clouds tend to occur more often in the afternoon, peaking around 1700 local time over land and ocean. The amplitude of cloud diurnal variation over ocean is much smaller than that over land, and complex terrain tends to be linked to larger amplitude. In vertical, the diurnal cycle of cloud frequency exhibits bimodal pattern over both land and ocean. The high-level peaks occur at almost the same altitude over land and ocean. In contrast, the low-level peaks over ocean mainly reside in the boundary layer, much lower than those over land, which could be indicative of the frequent occurrence of marine boundary layer clouds.

Development of standardized air-blown coal gasifier/gas turbine concepts for future electric power systems, Volume 4

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-02-01

This appendix is a compilation of work done to predict overall cycle performance from gasifier to generator terminals. A spreadsheet has been generated for each case to show flows within a cycle. The spreadsheet shows gaseous or solid composition of flow, temperature of flow, quantity of flow, and heat heat content of flow. Prediction of steam and gas turbine performance was obtained by the computer program GTPro. Outputs of all runs for each combined cycle reviewed has been added to this appendix. A process schematic displaying all flows predicted through GTPro and the spreadsheet is also added to this appendix.more » The numbered bubbles on the schematic correspond to columns on the top headings of the spreadsheet.« less

Bright field segmentation tomography (BFST) for use as surface identification in stereomicroscopy

NASA Astrophysics Data System (ADS)

Thiesse, Jacqueline R.; Namati, Eman; de Ryk, Jessica; Hoffman, Eric A.; McLennan, Geoffrey

2004-07-01

Stereomicroscopy is an important method for use in image acquisition because it provides a 3D image of an object when other microscopic techniques can only provide the image in 2D. One challenge that is being faced with this type of imaging is determining the top surface of a sample that has otherwise indistinguishable surface and planar characteristics. We have developed a system that creates oblique illumination and in conjunction with image processing, the top surface can be viewed. The BFST consists of the Leica MZ12 stereomicroscope with a unique attached lighting source. The lighting source consists of eight light emitting diodes (LED's) that are separated by 45-degree angles. Each LED in this system illuminates with a 20-degree viewing angle once per cycle with a shadow over the rest of the sample. Subsequently, eight segmented images are taken per cycle. After the images are captured they are stacked through image addition to achieve the full field of view, and the surface is then easily identified. Image processing techniques, such as skeletonization can be used for further enhancement and measurement. With the use of BFST, advances can be made in detecting surface features from metals to tissue samples, such as in the analytical assessment of pulmonary emphysema using the technique of mean linear intercept.

Improved SCR ac Motor Controller for Battery Powered Urban Electric Vehicles

NASA Technical Reports Server (NTRS)

Latos, T. S.

1982-01-01

An improved ac motor controller, which when coupled to a standard ac induction motor and a dc propulsion battery would provide a complete electric vehicle power train with the exception of the mechanical transmission and drive wheels was designed. In such a system, the motor controller converts the dc electrical power available at the battery terminals to ac electrical power for the induction motor in response to the drivers commands. The performance requirements of a hypothetical electric vehicle with an upper weight bound of 1590 kg (3500 lb) were used to determine the power rating of the controller. Vehicle acceleration capability, top speed, and gradeability requisites were contained in the Society of Automotive Engineers (SAE) Schedule 227a(d) driving cycle. The important capabilities contained in this driving cycle are a vehicle acceleration requirement of 0 to 72.4 kmph (0 to 45 mph) in 28 seconds a top speed of 88.5 kmph (55 mph), and the ability to negotiate a 10% grade at 48 kmph (30 mph). A 10% grade is defined as one foot of vertical rise per 10 feet of horizontal distance.

Closed Brayton Cycle Power Conversion Unit for Fission Surface Power Phase I Final Report

NASA Technical Reports Server (NTRS)

Fuller, Robert L.

2010-01-01

A Closed Brayton cycle power conversion system has been developed to support the NASA fission surface power program. The goal is to provide electricity from a small nuclear reactor heat source for surface power production for lunar and Mars environments. The selected media for a heat source is NaK 78 with water as a cooling source. The closed Brayton cycle power was selected to be 12 kWe output from the generator terminals. A heat source NaK temperature of 850 K plus or minus 25 K was selected. The cold source water was selected at 375 K plus or minus 25 K. A vacuum radiation environment of 200 K is specified for environmental operation. The major components of the system are the power converter, the power controller, and the top level data acquisition and control unit. The power converter with associated sensors resides in the vacuum radiation environment. The power controller and data acquisition system reside in an ambient laboratory environment. Signals and power are supplied across the pressure boundary electrically with hermetic connectors installed on the vacuum vessel. System level analyses were performed on working fluids, cycle design parameters, heater and cooling temperatures, and heat exchanger options that best meet the needs of the power converter specification. The goal is to provide a cost effective system that has high thermal-to-electric efficiency in a compact, lightweight package.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fang, Ming; Albrecht, Bruce A.; Ghate, Virendra P.

This study first illustrates the utility of using the Doppler spectrum width from millimetrewavelength radar to calculate the energy dissipation rate and then to use the energy dissipation rate to study turbulence structure in a continental stratocumulus cloud. It is shown that the turbulence kinetic energy dissipation rate calculated from the radar-measured Doppler spectrum width agrees well with that calculated from the Doppler velocity power spectrum. During the 16-h stratocumulus cloud event, the small-scale turbulence contributes 40%of the total velocity variance at cloud base, 50% at normalized cloud depth=0.8 and 70% at cloud top, which suggests that small-scale turbulence playsmore » a critical role near the cloud top where the entrainment and cloud-top radiative cooling act. The 16-h mean vertical integral length scale decreases from about 160 m at cloud base to 60 m at cloud top, and this signifies that the larger scale turbulence dominates around cloud base whereas the small-scale turbulence dominates around cloud top. The energy dissipation rate, total variance and squared spectrum width exhibit diurnal variations, but unlike marine stratocumulus they are high during the day and lowest around sunset at all levels; energy dissipation rates increase at night with the intensification of the cloud-top cooling. In the normalized coordinate system, the averaged coherent structure of updrafts is characterized by low energy dissipation rates in the updraft core and higher energy dissipation rates surround the updraft core at the top and along the edges. In contrast, the energy dissipation rate is higher inside the downdraft core indicating that the downdraft core is more turbulent. The turbulence around the updraft is weaker at night and stronger during the day; the opposite is true around the downdraft. This behaviour indicates that the turbulence in the downdraft has a diurnal cycle similar to that observed in marine stratocumuluswhereas the turbulence diurnal cycle in the updraft is reversed. For both updraft and downdraft, the maximum energy dissipation rate occurs at a cloud depth=0.8 where the maximum reflectivity and air acceleration or deceleration are observed. Resolved turbulence dominates near cloud base whereas unresolved turbulence dominates near cloud top. Similar to the unresolved turbulence, the resolved turbulence described by the radial velocity variance is higher in the downdraft than in the updraft. The impact of the surface heating on the resolved turbulence in the updraft decreases with height and diminishes around the cloud top. In both updrafts and downdrafts, the resolved turbulence increases with height and reaches a maximum at cloud depth=0.4 and then decreases to the cloud top; the resolved turbulence near cloud top, just as the unresolved turbulence, is mostly due to the cloud-top radiative cooling.« less

Engine system assessment study using Martian propellants

NASA Technical Reports Server (NTRS)

Pelaccio, Dennis; Jacobs, Mark; Scheil, Christine; Collins, John

1992-01-01

A top-level feasibility study was conducted that identified and characterized promising chemical propulsion system designs which use two or more of the following propellant combinations: LOX/H2, LOX/CH4, and LOX/CO. The engine systems examined emphasized the usage of common subsystem/component hardware where possible. In support of this study, numerous mission scenarios were characterized that used various combinations of Earth, lunar, and Mars propellants to establish engine system requirements to assess the promising engine system design concept examined, and to determine overall exploration leverage of such systems compared to state-of-the-art cryogenic (LOX/H2) propulsion systems. Initially in the study, critical propulsion system technologies were assessed. Candidate expander and gas generator cycle LOX/H2/CO, LOX/H2/CH4, and LOX/CO/CH4 engine system designs were parametrically evaluated. From this evaluation baseline, tripropellant Mars Transfer Vehicle (MTV) LOX cooled and bipropellant Lunar Excursion Vehicle (LEV) and Mars Excursion Vehicle (MEV) engine systems were identified. Representative tankage designs for a MTV were also investigated. Re-evaluation of the missions using the baseline engine design showed that in general the slightly lower performance, smaller, lower weight gas generator cycle-based engines required less overall mission Mars and in situ propellant production (ISPP) infrastructure support compared to the larger, heavier, higher performing expander cycle engine systems.

Landscape cultivation alters δ30Si signature in terrestrial ecosystems

PubMed Central

Vandevenne, Floor I.; Delvaux, Claire; Hughes, Harold J.; André, Luc; Ronchi, Benedicta; Clymans, Wim; Barão, Lúcia; Govers, Gerard; Meire, Patrick; Struyf, Eric

2015-01-01

Despite increasing recognition of the relevance of biological cycling for Si cycling in ecosystems and for Si export from soils to fluvial systems, effects of human cultivation on the Si cycle are still relatively understudied. Here we examined stable Si isotope (δ30Si) signatures in soil water samples across a temperate land use gradient. We show that – independent of geological and climatological variation – there is a depletion in light isotopes in soil water of intensive croplands and managed grasslands relative to native forests. Furthermore, our data suggest a divergence in δ30Si signatures along the land use change gradient, highlighting the imprint of vegetation cover, human cultivation and intensity of disturbance on δ30Si patterns, on top of more conventionally acknowledged drivers (i.e. mineralogy and climate). PMID:25583031

Indian Ocean Surface Circulations and Their Connection to Indian Ocean Dipole, Identified From Ocean Surface Currents Analysis Real Time (OSCAR) Data

DTIC Science & Technology

2008-06-01

31 1. Seasonal Development .......................................................................32 2. Winter Monsoon...summary of the monsoon system in the Indian Ocean. The top part indicates the wind cycle; the lower part shows the major currents that develop in...energy interests in the Indian Ocean’s waters. The rapid economic progress in developing nations, such as India and South Africa, also adds up their

Advanced power cycles and configurations for solar towers: Modeling and optimization of the decoupled solar combined cycle concept

NASA Astrophysics Data System (ADS)

García-Barberena, Javier; Olcoz, Asier; Sorbet, Fco. Javier

2017-06-01

CSP technologies are essential to allow large shares of renewables into the grid due to their unique ability to cope with the large variability of the energy resource by means of technically and economically feasible thermal energy storage (TES) systems. However, there is still the need and sought to achieve technological breakthroughs towards cost reductions and increased efficiencies. For this, research on advanced power cycles, like the Decoupled Solar Combined Cycle (DSCC) is, are regarded as a key objective. The DSCC concept is, basically, a Combined Brayton-Rankine cycle in which the bottoming cycle is decoupled from the operation of the topping cycle by means of an intermediate storage system. According to this concept, one or several solar towers driving a solar air receiver and a Gas Turbine (Brayton cycle) feed through their exhaust gasses a single storage system and bottoming cycle. This general concept benefits from a large flexibility in its design. On the one hand, different possible schemes related to number and configuration of solar towers, storage systems media and configuration, bottoming cycles, etc. are possible. On the other, within a specific scheme a large number of design parameters can be optimized, including the solar field size, the operating temperatures and pressures of the receiver, the power of the Brayton and Rankine cycles, the storage capacity and others. Heretofore, DSCC plants have been analyzed by means of simple steady-state models with pre-stablished operating parameters in the power cycles. In this work, a detailed transient simulation model for DSCC plants has been developed and is used to analyze different DSCC plant schemes. For each of the analyzed plant schemes, a sensitivity analysis and selection of the main design parameters is carried out. Results show that an increase in annual solar to electric efficiency of 30% (from 12.91 to 16.78) can be achieved by using two bottoming Rankine cycles at two different temperatures, enabling low temperature heat recovery from the receiver and Gas Turbine exhaust gasses.

An integrated approach to system design, reliability, and diagnosis

NASA Technical Reports Server (NTRS)

Patterson-Hine, F. A.; Iverson, David L.

1990-01-01

The requirement for ultradependability of computer systems in future avionics and space applications necessitates a top-down, integrated systems ingeneering approach for design, implementation, testing, and operation. The functional analyses of hardware and software systems must be combined by models that are flexible enough to represent their interactions and behavior. The information contained in these models must be accessible throughout all phases of the system life cycle in order to maintain consistency and accuracy in design and operational decisions. One approach being taken by researchers at Ames Research Center is the creation of an object-oriented environment that integrates information about system components required in the reliability evaluation with behavioral information useful for diagnostic algorithms.

NASA systems engineering handbook

NASA Astrophysics Data System (ADS)

Shishko, Robert; Aster, Robert; Chamberlain, Robert G.; McDuffee, Patrick; Pieniazek, Les; Rowell, Tom; Bain, Beth; Cox, Renee I.; Mooz, Harold; Polaski, Lou

1995-06-01

This handbook brings the fundamental concepts and techniques of systems engineering to NASA personnel in a way that recognizes the nature of NASA systems and environment. It is intended to accompany formal NASA training courses on systems engineering and project management when appropriate, and is designed to be a top-level overview. The concepts were drawn from NASA field center handbooks, NMI's/NHB's, the work of the NASA-wide Systems Engineering Working Group and the Systems Engineering Process Improvement Task team, several non-NASA textbooks and guides, and material from independent systems engineering courses taught to NASA personnel. Five core chapters cover systems engineering fundamentals, the NASA Project Cycle, management issues in systems engineering, systems analysis and modeling, and specialty engineering integration. It is not intended as a directive.

Enterprise systems' life cycle in pursuit of resilient smart factory for emerging aircraft industry: a synthesis of Critical Success Factors'(CSFs), theory, knowledge gaps, and implications

NASA Astrophysics Data System (ADS)

Rashid, Asif; Masood, Tariq; Erkoyuncu, John Ahmet; Tjahjono, Benny; Khan, Nawar; Shami, Muiz-ud-din

2018-02-01

The research aims to investigate business value critical success factors (CSFs) of enterprise systems (ES) through their life cycle in pursuit of resilient smart factory for emerging aircraft industry. This article provides an extensive literature analysis of past 22 years based on conscientious criteria of authors: (i) who have published strategic content relevant to CSFs, (ii) received more than 300 citations and (iii) concurrently published two or more papers relevant to ES CSFs. The most cited strategic CSFs were termed as classical CSFs. The 22 CSFs were identified, validated and synthesised for better understanding of success across life cycle by aircraft industry experts. The top 10 empirically verified CSFs have numerous differences with past generic classical CSFs. This article canvases real insights of two distinct views: process and variance approaches of the ES CSFs. The process approach, which is a neglected research area, facilitates the researchers for identification of ES life cycle process coupled with a view of resource deployment when it is needed the most. While the variance approach facilitates practitioners and researchers in finding out which resource (CSF) is relatively more important. The significant findings for ES life cycle can help the practitioners and researchers to make rational decisions throughout the ES life cycle.

Urbanization and the Carbon Cycle: Synthesis of Ongoing Research

NASA Astrophysics Data System (ADS)

Gurney, K. R.; Duren, R. M.; Hutyra, L.; Ehleringer, J. R.; Patarasuk, R.; Song, Y.; Huang, J.; Davis, K.; Kort, E. A.; Shepson, P. B.; Turnbull, J. C.; Lauvaux, T.; Rao, P.; Eldering, A.; Miller, C. E.; Wofsy, S.; McKain, K.; Mendoza, D. L.; Lin, J. C.; Sweeney, C.; Miles, N. L.; Richardson, S.; Cambaliza, M. O. L.

2015-12-01

Given the explosive growth in urbanization and its dominant role in current and future global greenhouse gas emissions, urban areas have received increasing research attention from the carbon cycle science community. The emerging focus is driven by the increasingly dense atmospheric observing capabilities - ground and space-based - in addition to the rising profile of cities within international climate change policymaking. Dominated by anthropogenic emissions, urban carbon cycle research requires a cross-disciplinary perspective with contributions from disciplines such as engineering, economics, social theory, and atmospheric science. We review the recent results from a sample of the active urban carbon research efforts including the INFLUX experiment (Indianapolis), the Megacity carbon project (Los Angeles), Salt Lake City, and Boston. Each of these efforts represent unique approaches in pursuit of different scientific and policy questions and assist in setting priorities for future research. From top-down atmospheric measurement systems to bottom-up estimation, these research efforts offer a view of the challenges and opportunities in urban carbon cycle research.

Induced natural convection thermal cycling device

DOEpatents

Heung, Leung Kit [Aiken, SC

2002-08-13

A device for separating gases, especially isotopes, by thermal cycling of a separation column using a pressure vessel mounted vertically and having baffled sources for cold and heat. Coils at the top are cooled with a fluid such as liquid nitrogen. Coils at the bottom are either electrical resistance coils or a tubular heat exchange. The sources are shrouded with an insulated "top hat" and simultaneously opened and closed at the outlets to cool or heat the separation column. Alternatively, the sources for cold and heat are mounted separately outside the vessel and an external loop is provided for each circuit.

21. VIEW EAST OF GENERATOR IN SOUTH END OF GRANITEVILLE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

21. VIEW EAST OF GENERATOR IN SOUTH END OF GRANITEVILLE MILL BASEMENT. A LEFFEL HYDRAULIC VERTICAL SHAFT TYPE F TURBINE CAPABLE OF PRODUCING 615HP AT 327RPM WITH 40 FEET OF HEAD PRESSURE SITS BELOW THE GENERATOR SHOWN AT LEFT CENTER OF THE PHOTOGRAPH. THIS IS COUPLED TO THE WESTINGHOUSE THREE-PHASE, 60 CYCLE ALTERNATING CURRENT GENERATOR IN THE PHOTO. THE GENERATOR DELIVERED 583 KVA AT 600 VOLTS. IT WAS RATED AT 640 AMPHERES. EXCITATION POWER WAS PROVIDED BY A SMALLER GENERATOR MOUNTED VERTICALLY ON TOP OF THE SHAFT COMMON TO BOTH GENERATORS. THE EXCITER, AT TOP LEFT CENTER, PROVIDED 125 VOLTS AT 60 AMPERES. CONTROL PANEL IS AT THE RIGHT OF THE PHOTO. THIS SYSTEM RAN UNTIL THE EARLY 1990s. - Graniteville Mill, Marshall Street, Graniteville, Aiken County, SC

The COMPASS Tokamak Plasma Control Software Performance

NASA Astrophysics Data System (ADS)

Valcarcel, Daniel F.; Neto, André; Carvalho, Ivo S.; Carvalho, Bernardo B.; Fernandes, Horácio; Sousa, Jorge; Janky, Filip; Havlicek, Josef; Beno, Radek; Horacek, Jan; Hron, Martin; Panek, Radomir

2011-08-01

The COMPASS tokamak has began operation at the IPP Prague in December 2008. A new control system has been built using an ATCA-based real-time system developed at IST Lisbon. The control software is implemented on top of the MARTe real-time framework attaining control cycles as short as 50 μs, with a jitter of less than 1 μs. The controlled parameters, important for the plasma performance, are the plasma current, position of the plasma current center, boundary shape and horizontal and vertical velocities. These are divided in two control cycles: slow at 500 μs and fast at 50 μs. The project has two phases. First, the software implements a digital controller, similar to the analog one used during the COMPASS-D operation in Culham. In the slow cycle, the plasma current and position are measured and controlled with PID and feedforward controllers, respectively, the shaping magnetic field is preprogrammed. The vertical instability and horizontal equilibrium are controlled with the faster 50-μs cycle PID controllers. The second phase will implement a plasma-shape reconstruction algorithm and controller, aiming at optimized plasma performance. The system was designed to be as modular as possible by breaking the functional requirements of the control system into several independent and specialized modules. This splitting enabled tuning the execution of each system part and to use the modules in a variety of applications with different time constraints. This paper presents the design and overall performance of the COMPASS control software.

Assimilation of GOES satellite-based convective initiation and cloud growth observations into the Rapid Refresh and HRRR systems to improve aviation forecast guidance

NASA Astrophysics Data System (ADS)

Mecikalski, John; Smith, Tracy; Weygandt, Stephen

2014-05-01

Latent heating profiles derived from GOES satellite-based cloud-top cooling rates are being assimilated into a retrospective version of the Rapid Refresh system (RAP) being run at the Global Systems Division. Assimilation of these data may help reduce the time lag for convection initiation (CI) in both the RAP model forecasts and in 3-km High Resolution Rapid Refresh (HRRR) model runs that are initialized off of the RAP model grids. These data may also improve both the location and organization of developing convective storm clusters, especially in the nested HRRR runs. These types of improvements are critical for providing better convective storm guidance around busy hub airports and aviation corridor routes, especially in the highly congested Ohio Valley - Northeast - Mid-Atlantic region. Additional work is focusing on assimilating GOES-R CI algorithm cloud-top cooling-based latent heating profiles directly into the HRRR model. Because of the small-scale nature of the convective phenomena depicted in the cloud-top cooling rate data (on the order of 1-4 km scale), direct assimilation of these data in the HRRR may be more effective than assimilation in the RAP. The RAP is an hourly assimilation system developed at NOAA/ESRL and was implemented at NCEP as a NOAA operational model in May 2012. The 3-km HRRR runs hourly out to 15 hours as a nest within the ESRL real-time experimental RAP. The RAP and HRRR both use the WRF ARW model core, and the Gridpoint Statistical Interpolation (GSI) is used within an hourly cycle to assimilate a wide variety of observations (including radar data) to initialize the RAP. Within this modeling framework, the cloud-top cooling rate-based latent heating profiles are applied as prescribed heating during the diabatic forward model integration part of the RAP digital filter initialization (DFI). No digital filtering is applied on the 3-km HRRR grid, but similar forward model integration with prescribed heating is used to assimilate information from radar reflectivity, lightning flash density and the satellite based cloud-top cooling rate data. In the current HRRR configuration, 4 15-min cycles of latent heating are applied during a pre-forecast hour of integration. This is followed by a final application of GSI at 3-km to fit the latest conventional observation data. At the conference, results from a 5-day retrospective period (July 5-10, 2012) will be shown, focusing on assessment of data impact for both the RAP and HRRR, as well as the sensitivity to various assimilation parameters, including assumed heating strength. Emphasis will be given to documenting the forecast impacts for aviation applications in the Eastern U.S.

NASA Systems Engineering Handbook

NASA Technical Reports Server (NTRS)

Hirshorn, Steven R.; Voss, Linda D.; Bromley, Linda K.

2017-01-01

The update of this handbook continues the methodology of the previous revision: a top-down compatibility with higher level Agency policy and a bottom-up infusion of guidance from the NASA practitioners in the field. This approach provides the opportunity to obtain best practices from across NASA and bridge the information to the established NASA systems engineering processes and to communicate principles of good practice as well as alternative approaches rather than specify a particular way to accomplish a task. The result embodied in this handbook is a top-level implementation approach on the practice of systems engineering unique to NASA. Material used for updating this handbook has been drawn from many sources, including NPRs, Center systems engineering handbooks and processes, other Agency best practices, and external systems engineering textbooks and guides. This handbook consists of six chapters: (1) an introduction, (2) a systems engineering fundamentals discussion, (3) the NASA program project life cycles, (4) systems engineering processes to get from a concept to a design, (5) systems engineering processes to get from a design to a final product, and (6) crosscutting management processes in systems engineering. The chapters are supplemented by appendices that provide outlines, examples, and further information to illustrate topics in the chapters. The handbook makes extensive use of boxes and figures to define, refine, illustrate, and extend concepts in the chapters.

Wave rotor demonstrator engine assessment

NASA Technical Reports Server (NTRS)

Snyder, Philip H.

1996-01-01

The objective of the program was to determine a wave rotor demonstrator engine concept using the Allison 250 series engine. The results of the NASA LERC wave rotor effort were used as a basis for the wave rotor design. A wave rotor topped gas turbine engine was identified which incorporates five basic requirements of a successful demonstrator engine. Predicted performance maps of the wave rotor cycle were used along with maps of existing gas turbine hardware in a design point study. The effects of wave rotor topping on the engine cycle and the subsequent need to rematch compressor and turbine sections in the topped engine were addressed. Comparison of performance of the resulting engine is made on the basis of wave rotor topped engine versus an appropriate baseline engine using common shaft compressor hardware. The topped engine design clearly demonstrates an impressive improvement in shaft horsepower (+11.4%) and SFC (-22%). Off design part power engine performance for the wave rotor topped engine was similarly improved including that at engine idle conditions. Operation of the engine at off design was closely examined with wave rotor operation at less than design burner outlet temperatures and rotor speeds. Challenges identified in the development of a demonstrator engine are discussed. A preliminary design was made of the demonstrator engine including wave rotor to engine transition ducts. Program cost and schedule for a wave rotor demonstrator engine fabrication and test program were developed.

Unsteady surface pressure measurements on a slender delta wing undergoing limit cycle wing rock

NASA Technical Reports Server (NTRS)

Arena, Andrew S., Jr.; Nelson, Robert C.

1991-01-01

An experimental investigation of slender wing limit cycle motion known as wing rock was investigated using two unique experimental systems. Dynamic roll moment measurements and visualization data on the leading edge vortices were obtained using a free to roll apparatus that incorporates an airbearing spindle. In addition, both static and unsteady surface pressure data was measured on the top and bottom surfaces of the model. To obtain the unsteady surface pressure data a new computer controller drive system was developed to accurately reproduce the free to roll time history motions. The data from these experiments include, roll angle time histories, vortex trajectory data on the position of the vortices relative to the model's surface, and surface pressure measurements as a function of roll angle when the model is stationary or undergoing a wing rock motion. The roll time history data was numerically differentiated to determine the dynamic roll moment coefficient. An analysis of these data revealed that the primary mechanism for the limit cycle behavior was a time lag in the position of the vortices normal to the wing surface.

Stability and Bifurcation Analysis of a Three-Species Food Chain Model with Fear

NASA Astrophysics Data System (ADS)

Panday, Pijush; Pal, Nikhil; Samanta, Sudip; Chattopadhyay, Joydev

In the present paper, we investigate the impact of fear in a tri-trophic food chain model. We propose a three-species food chain model, where the growth rate of middle predator is reduced due to the cost of fear of top predator, and the growth rate of prey is suppressed due to the cost of fear of middle predator. Mathematical properties such as equilibrium analysis, stability analysis, bifurcation analysis and persistence have been investigated. We also describe the global stability analysis of the equilibrium points. Our numerical simulations reveal that cost of fear in basal prey may exhibit bistability by producing unstable limit cycles, however, fear in middle predator can replace unstable limit cycles by a stable limit cycle or a stable interior equilibrium. We observe that fear can stabilize the system from chaos to stable focus through the period-halving phenomenon. We conclude that chaotic dynamics can be controlled by the fear factors. We apply basic tools of nonlinear dynamics such as Poincaré section and maximum Lyapunov exponent to identify the chaotic behavior of the system.

Force-velocity relationship in cycling revisited: benefit of two-dimensional pedal forces analysis.

PubMed

Dorel, Sylvain; Couturier, Antoine; Lacour, Jean-René; Vandewalle, Henry; Hautier, Christophe; Hug, François

2010-06-01

Maximal cycling exercise has been widely used to describe the power-velocity characteristics of lower-limb extensor muscles. This study investigated the contribution of each functional sector (i.e., extension, flexion, and transitions sectors) on the total force produced over a complete pedaling cycle. We also examined the ratio of effective force to the total pedal force, termed index of mechanical effectiveness (IE), in explaining differences in power between subjects. Two-dimensional pedal forces and crank angles were measured during a cycling force-velocity test performed by 14 active men. Mean values of forces, power output, and IE over four functional angular sectors were assessed: top = 330 degrees -30 degrees , downstroke = 30 degrees -150 degrees , bottom = 150 degrees -210 degrees , and upstroke = 210 degrees -330 degrees . Linear and quadratic force-velocity and power-velocity relationships were obtained for downstroke and upstroke. Maximal power output (Pmax) generated over these two sectors represented, respectively, 73.6% +/- 2.6% and 10.3% +/- 1.8% of Pmax assessed over the entire cycle. In the whole group, Pmax over the complete cycle was significantly related to Pmax during the downstroke and upstroke. IE significantly decreased with pedaling rate, especially in bottom and upstroke. There were significant relationships between power output and IE for top and upstroke when the pedaling rate was below or around the optimal value and in all the sectors at very high cadences. Although data from force-velocity test primarily characterize the muscular function involved in the downstroke phase, they also reflect the flexor muscles' ability to actively pull on the pedal during the upstroke. IE influences the power output in the upstroke phase and near the top dead center, and IE accounts for differences in power between subjects at high pedaling rates.

Repeated sedimentation and exposure of glacial Lake Missoula sediments: A lake-level history at Garden Gulch, Montana, USA

NASA Astrophysics Data System (ADS)

Smith, Larry N.

2017-01-01

Glaciolacustrine sediments record lake transgression, regression, and subaerial modification of the silty lake-bottom of glacial Lake Missoula in the Clark Fork River valley. The sequence preserved at Garden Gulch, MT documents lake-level fluctuations at >65% of its full-pool volume. Twelve sedimentary cycles fine upwards from (1) very fine-grained sandy silt to (2) silt with climbing ripples to (3) rhythmically laminated silt and some clay. The cycles are fine-grained turbidites capped locally by thin layers of angular gravel derived from local bedrock outcrops. The gravels appear to be the toes of mass wasting lobes carried onto the exposed lakebed surface during repeated lake-level lowerings. Periglacial wedges, small rotational faults, involutions, and clastic dikes deform the tops of eleven cycles. The wedges are 10-30 cm wide, penetrate 30-70 cm deep, are spaced <1 m apart, and contain vertically oriented gravel and massive to laminated sediment. Wedges split and taper in plan view. A few thin silt-filled dikes, which branch and taper downwards from wedges, are interpreted as filled frost cracks. One 10-20 cm-wide sand-filled dike protrudes upward from a sand bed; it is interpreted as a liquefaction feature consistent with a filling and draining lake. The deformed cycle tops preserve evidence of periglacial cold, subaerial exposure, seasonal frost heave, and the incipient formation of sorted polygons. The lowest five cycles are thicker and display more periglacial modification at their tops than the upper seven cycles. The Garden Gulch section may represent as few as seven and as many as twelve substantial fillings and partial to complete drainings of glacial Lake Missoula.

Energy and cost savings results for advanced technology systems from the Cogeneration Technology Alternatives Study /CTAS/

NASA Technical Reports Server (NTRS)

Sagerman, G. D.; Barna, G. J.; Burns, R. K.

1979-01-01

The Cogeneration Technology Alternatives Study (CTAS), a program undertaken to identify the most attractive advanced energy conversion systems for industrial cogeneration applications in the 1985-2000 time period, is described, and preliminary results are presented. Two cogeneration options are included in the analysis: a topping application, in which fuel is input to the energy conversion system which generates electricity and waste heat from the conversion system is used to provide heat to the process, and a bottoming application, in which fuel is burned to provide high temperature process heat and waste heat from the process is used as thermal input to the energy conversion system which generates energy. Steam turbines, open and closed cycle gas turbines, combined cycles, diesel engines, Stirling engines, phosphoric acid and molten carbonate fuel cells and thermionics are examined. Expected plant level energy savings, annual energy cost savings, and other results of the economic analysis are given, and the sensitivity of these results to the assumptions concerning fuel prices, price of purchased electricity and the potential effects of regional energy use characteristics is discussed.

Novel, Integrated Reactor / Power Conversion System (LMR-AMTEC)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pablo Rubiolo, Principal Investigator

2003-03-21

The main features of this project were the development of a long life (up to 10 years) Liquid Metal Reactor (LMR) and a static conversion subsystem comprising an Alkali Metal Thermal-to-Electric (AMTEC) topping cycle and a ThermoElectric (TE) Bottom cycle. Various coupling options of the LMR with the energy conversion subsystem were explored and, base in the performances found in this analysis, an Indirect Coupling (IC) between the LMR and the AMTEC/TE converters with Alkali Metal Boilers (AMB) was chosen as the reference design. The performance model of the fully integrated sodium-and potassium-AMTEC/TE converters shows that a combined conversion efficiencymore » in excess of 30% could be achieved by the plant. (B204)« less

NASA Systems Engineering Handbook

NASA Technical Reports Server (NTRS)

Shishko, Robert; Aster, Robert; Chamberlain, Robert G.; Mcduffee, Patrick; Pieniazek, Les; Rowell, Tom; Bain, Beth; Cox, Renee I.; Mooz, Harold; Polaski, Lou

1995-01-01

This handbook brings the fundamental concepts and techniques of systems engineering to NASA personnel in a way that recognizes the nature of NASA systems and environment. It is intended to accompany formal NASA training courses on systems engineering and project management when appropriate, and is designed to be a top-level overview. The concepts were drawn from NASA field center handbooks, NMI's/NHB's, the work of the NASA-wide Systems Engineering Working Group and the Systems Engineering Process Improvement Task team, several non-NASA textbooks and guides, and material from independent systems engineering courses taught to NASA personnel. Five core chapters cover systems engineering fundamentals, the NASA Project Cycle, management issues in systems engineering, systems analysis and modeling, and specialty engineering integration. It is not intended as a directive. Superseded by: NASA/SP-2007-6105 Rev 1 (20080008301).

On the Home Front: Early Care and Education a Top Priority for Military Families

ERIC Educational Resources Information Center

Coleman, Alice

2011-01-01

Military parents with young children report that the need for early care and education services, including high-quality pre-kindergarten, tops their list of day-to-day needs. Frequent relocations and the cycle of deployment--preparation, separation and reunification--all cause disruptions that can have profound emotional and educational…

Warming shifts top-down and bottom-up control of pond food web structure and function

PubMed Central

Shurin, Jonathan B.; Clasen, Jessica L.; Greig, Hamish S.; Kratina, Pavel; Thompson, Patrick L.

2012-01-01

The effects of global and local environmental changes are transmitted through networks of interacting organisms to shape the structure of communities and the dynamics of ecosystems. We tested the impact of elevated temperature on the top-down and bottom-up forces structuring experimental freshwater pond food webs in western Canada over 16 months. Experimental warming was crossed with treatments manipulating the presence of planktivorous fish and eutrophication through enhanced nutrient supply. We found that higher temperatures produced top-heavy food webs with lower biomass of benthic and pelagic producers, equivalent biomass of zooplankton, zoobenthos and pelagic bacteria, and more pelagic viruses. Eutrophication increased the biomass of all organisms studied, while fish had cascading positive effects on periphyton, phytoplankton and bacteria, and reduced biomass of invertebrates. Surprisingly, virus biomass was reduced in the presence of fish, suggesting the possibility for complex mechanisms of top-down control of the lytic cycle. Warming reduced the effects of eutrophication on periphyton, and magnified the already strong effects of fish on phytoplankton and bacteria. Warming, fish and nutrients all increased whole-system rates of net production despite their distinct impacts on the distribution of biomass between producers and consumers, plankton and benthos, and microbes and macrobes. Our results indicate that warming exerts a host of indirect effects on aquatic food webs mediated through shifts in the magnitudes of top-down and bottom-up forcing. PMID:23007089

Global Ocean Forecast System 3.1 Validation Test

DTIC Science & Technology

2017-05-04

number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 5d. PROJECT NUMBER 5e. TASK...cycle with the Navy Coupled Ocean Data Assimilation. Additionally it uses Improved Synthetic Ocean Profiles to project surface information downward into...are retained, with the additional 9 layers all located near the surface such that at least the top 14 layers are always sigma -z levels so that water

ANDRILL Borehole AND-1B: Well Log Analysis of Lithofacies and Glacimarine Cycles.

NASA Astrophysics Data System (ADS)

Jackolski, C. L.; Williams, T.; Powell, R. D.; Jarrard, R.; Morin, R. H.; Talarico, F. M.; Niessen, F.; Kuhn, G.

2008-12-01

During the 2006-2007 austral summer, the Antarctic geological drilling program ANDRILL recovered cores of sedimentary rock from a 1285-m-deep borehole below the McMurdo Ice Shelf. Well logging instruments were deployed to a depth of 1017 mbsf after core recovery. This study focuses on two intervals of the AND-1B borehole: upper HQ (238-343 mbsf; Pliocene) and NQ (698-1017 mbsf; upper Miocene), which were logged with natural gamma ray, induction resistivity and magnetic susceptibility tools. To understand how the well logs fit into a more complete physical properties data set, we performed factor and cluster analyses on a suite of well logs and core logs in the upper HQ and NQ intervals. In both intervals, factor analysis groups resistivity and core P-velocity into a factor that we interpret as being inversely proportional to porosity. It also groups natural gamma and potassium (from the XRF core scanner) into a factor that we interpret as a particle-size or lithology index. An additional factor in the NQ interval, influenced by clast number and magnetic susceptibility, distinguishes subglacial diamictites from other lithofacies. The factors in each interval (2 in HQ, 3 in NQ) are used as input to cluster analysis. The results are log data objectively organized into clusters, or electrofacies. We compare these electrofacies to the lithofacies, well logs and unconformity-bounded glacimarine cycles of AND-1B. Patterns in the glacimarine cycles are observed in the well logs and electrofacies. In the NQ glacimarine sediments, an electrofacies pattern is produced between subglacial diamictites at the bottom of each sequence and the glacial retreat facies above. Subglacial diamictites have higher values for the additional NQ factor, corresponding to clast number and magnetic susceptibility, than the muds and sands that form the retreat facies. Differences in the porosity factor are not observed in any electrofacies pattern in the NQ interval, but subtle patterns in the resistivity well log are observed. Subglacial diamictites have greater resistivities than most retreat facies. In the HQ interval, there is only one glacimarine cycle that resembles those in the NQ interval, and most of the interval is subglacial or ice-proximal diamictite. There are only two and a half cycles in the HQ interval, but they contain an incipient electrofacies pattern. In the lower two cycles, the potassium/gamma factor is low at the bottom and high toward the top, and porosity, as indicated by the porosity factor, is low at the bottom and high toward the top. Throughout most of the HQ interval, potassium and natural gamma correlate with porosity. Two exceptions are the lower half of the top cycle, in which resistivity increases toward the top, and the two diatomite beds at the top of the two lower cycles, in which potassium/gamma is low and porosity is very high.

Covariability in the Monthly Mean Convective and Radiative Diurnal Cycles in the Amazon

NASA Technical Reports Server (NTRS)

Dodson, Jason B.; Taylor, Patrick C.

2015-01-01

The diurnal cycle of convective clouds greatly influences the radiative energy balance in convectively active regions of Earth, through both direct presence, and the production of anvil and stratiform clouds. Previous studies show that the frequency and properties of convective clouds can vary on monthly timescales as a result of variability in the monthly mean atmospheric state. Furthermore, the radiative budget in convectively active regions also varies by up to 7 Wm-2 in convectively active regions. These facts suggest that convective clouds connect atmospheric state variability and radiation variability beyond clear sky effects alone. Previous research has identified monthly covariability between the diurnal cycle of CERES-observed top-of-atmosphere radiative fluxes and multiple atmospheric state variables from reanalysis over the Amazon region. ASVs that enhance (reduce) deep convection, such as CAPE (LTS), tend to shift the daily OLR and cloud albedo maxima earlier (later) in the day by 2-3 hr. We first test the analysis method using multiple reanalysis products for both the dry and wet seasons to further investigate the robustness of the preliminary results. We then use CloudSat data as an independent cloud observing system to further evaluate the relationships of cloud properties to variability in radiation and atmospheric states. While CERES can decompose OLR variability into clear sky and cloud effects, it cannot determine what variability in cloud properties lead to variability in the radiative cloud effects. Cloud frequency, cloud top height, and cloud microphysics all contribute to the cloud radiative effect, all of which are observable by CloudSat. In addition, CloudSat can also observe the presence and variability of deep convective cores responsible for the production of anvil clouds. We use these capabilities to determine the covariability of convective cloud properties and the radiative diurnal cycle.

The effects of sea level and palaeotopography on lithofacies distribution and geometries in heterozoan carbonates, south-eastern Spain

USGS Publications Warehouse

Johnson, C.L.; Franseen, E.K.; Goldstein, R.H.

2005-01-01

This study utilized three-dimensional exposures to evaluate how sea-level position and palaeotopography control the facies and geometries of heterozoan carbonates. Heterozoan carbonates were deposited on top of a Neogene volcanic substrate characterized by palaeotopographic highs, palaeovalleys, and straits that were formed by subaerial erosion, possibly original volcanic topography, and faults prior to carbonate deposition. The depositional sequence that is the focus of this study (DS1B) consists of 7-10 fining upward cycles that developed in response to relative sea-level fluctuations. A complete cycle has a basal erosion surface overlain by deposits of debrisflows and high-density turbidity currents, which formed during relative sea-level fall. Overlying tractive deposits most likely formed during the lowest relative position of sea level. Overlying these are debrites grading upward to high-density turbidites and low-density turbidites that formed during relative sea-level rise. The tops of the cycles consist of hemipelagic deposits that formed during the highest relative position of sea level. The cycles fine upward because upslope carbonate production decreased as relative sea level rose due to less surface area available for shallow-water carbonate production and partial drowning of substrates. The cycles are dominated by two end-member types of facies associations and stratal geometries that formed in response to fluctuating sea-level position over variable substrate palaeotopography. One end-member is termed 'flank flow cycle' because this type of cycle indicates dominant sediment transport down the flanks of palaeovalleys. Those cycles drape the substrate, have more debrites, high-density turbidites and erosion on palaeovalley flanks, and in general, the lithofacies fine down the palaeovalley flanks into the palaeovalley axes. The second end-member is termed 'axial flow cycle' because it indicates a dominance of sediment transport down the axes of palaeovalleys. Those cycles are characterized by debrites and high-density turbidites in palaeovalley axes, and lap out of strata against the flanks of palaeovalleys. Where and when an axial flow cycle or flank flow cycle developed appears to be related to the intersection of sea level with areas of gentle or steep substrate slopes, during an overall relative rise in sea level. Results from this study provide a model for similar systems that must combine carbonate principles for sediment production, palaeotopographic controls, and physical principles of sediment remobilization into deep water. ?? 2005 International Association of Sedimentologists.

40 CFR 97.402 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... fossil- or other-fuel-fired combustion device used to produce heat and to transfer heat to recirculating... the sequential use of energy. Cogeneration unit means a stationary, fossil-fuel-fired boiler or stationary, fossil-fuel-fired combustion turbine that is a topping-cycle unit or a bottoming-cycle unit: (1...

40 CFR 97.402 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... fossil- or other-fuel-fired combustion device used to produce heat and to transfer heat to recirculating... the sequential use of energy. Cogeneration unit means a stationary, fossil-fuel-fired boiler or stationary, fossil-fuel-fired combustion turbine that is a topping-cycle unit or a bottoming-cycle unit: (1...

40 CFR 97.402 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... fossil- or other-fuel-fired combustion device used to produce heat and to transfer heat to recirculating... the sequential use of energy. Cogeneration unit means a stationary, fossil-fuel-fired boiler or stationary, fossil-fuel-fired combustion turbine that is a topping-cycle unit or a bottoming-cycle unit: (1...

Leading Teams of Higher Education Administrators: Integrating Goal Setting, Team Role, and Team Life Cycle Theories

ERIC Educational Resources Information Center

Posthuma, Richard; Al-Riyami, Said

2012-01-01

Leaders of higher education institutions can create top management teams of academic administrators to guide and improve their organizations. This study illustrates how the leadership of top management teams can be accomplished successfully through a combination of goal setting (Doran, 1981; Locke & Latham, 1990), understanding of team roles…

PBO H2O: Plate Boundary Observatory Studies of the Water Cycle

NASA Astrophysics Data System (ADS)

Larson, K. M.; Small, E. E.; Chew, C. C.; Nievinski, F. G.; Pratt, J.; McCreight, J. L.; Braun, J.; Boniface, K.; Evans, S. G.

2013-12-01

The EarthScope Plate Boundary Observatory was built to measure the deformation of the North American continent. PBO stations can also be used to measure ground displacements at much higher frequencies (5-Hz) for studies of fault slip during large earthquakes and for warnings of volcanic eruptions. There is also a long history of using atmospheric delays on the GPS signals to estimate precipitable water vapor (for weather and climate studies) and total electron content (space weather studies). Recently the PBO H2O research group has demonstrated that GPS signals that reflect from the nearby environment can be used for water cycle research. These GPS reflections measure how much water is in the top layer of the soil, how much snow is on its surface, and water content of nearby vegetation. Observing and monitoring spatial and temporal changes in the water cycle is critical for both understanding and predicting Earth's climate. Since GPS reflections encompass an area of ~1000 m^2, they provide a spatial footprint that complements satellite systems which sense much larger areas and in situ systems that sense regions < 1 m^2. Water cycle products are produced from PBO data each day and updated on the PBO H2O website.

Parametric analysis of closed cycle magnetohydrodynamic (MHD) power plants

NASA Technical Reports Server (NTRS)

Owens, W.; Berg, R.; Murthy, R.; Patten, J.

1981-01-01

A parametric analysis of closed cycle MHD power plants was performed which studied the technical feasibility, associated capital cost, and cost of electricity for the direct combustion of coal or coal derived fuel. Three reference plants, differing primarily in the method of coal conversion utilized, were defined. Reference Plant 1 used direct coal fired combustion while Reference Plants 2 and 3 employed on site integrated gasifiers. Reference Plant 2 used a pressurized gasifier while Reference Plant 3 used a ""state of the art' atmospheric gasifier. Thirty plant configurations were considered by using parametric variations from the Reference Plants. Parametric variations include the type of coal (Montana Rosebud or Illinois No. 6), clean up systems (hot or cold gas clean up), on or two stage atmospheric or pressurized direct fired coal combustors, and six different gasifier systems. Plant sizes ranged from 100 to 1000 MWe. Overall plant performance was calculated using two methodologies. In one task, the channel performance was assumed and the MHD topping cycle efficiencies were based on the assumed values. A second task involved rigorous calculations of channel performance (enthalpy extraction, isentropic efficiency and generator output) that verified the original (task one) assumptions. Closed cycle MHD capital costs were estimated for the task one plants; task two cost estimates were made for the channel and magnet only.

Preliminary assessment of a potassium-steam-gas vapor cycle for better fuel economy and reduced thermal pollution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fraas, A.P.

1971-08-01

The facts of fuel supply limitations, environmental quality demands, and spiraling electric generating costs strongly favor development of electric power plants that simultaneously run at higher efficiency, i.e., higher temperature, use to advantage clean fuels, and have as low a capital cost as possible. Both fuel supply and thermal pollution considerations that are becoming progressively more important strongly favor the development of a higher temperature, and more efficient, thermodynamic cycle for electric power plants. About 200,000 hr of operation of boiling potassium systems, including over 15,000 hr of potassium vapor turbine operation under the space power plant program, suggest thatmore » a potassium vapor topping cycle with a turbine inlet temperature of approximately 1500/sup 0/F merits consideration. A design study has been carried out to indicate the size, cost, and development problems of the new types of equipment required. The results indicate that a potassium vapor cycle superimposed on a conventional 1050/sup 0/F steam cycle would give an overall thermal efficiency of about 54% as compared to only 40% from a conventional steam cycle. Thus the proposed system would have a fuel consumption only 75% and a heat rejection rate only 50% that of a conventional plant. The system requires clean fuel, and takes advantage of the present trend toward eliminating SO/sub 2/, NO/sub x/ and ash emissions. Surprisingly, at first sight, the assessment at this stage shows that the capital cost may be less than that of a conventional plant. The main reason for this is use of pressurized combustion, which leads to a much smaller combustor, and thin tube walls to contain potassium at about the same pressure.« less

Heat transfer and phase transitions of water in multi-layer cryolithozone-surface systems

NASA Astrophysics Data System (ADS)

Khabibullin, I. L.; Nigametyanova, G. A.; Nazmutdinov, F. F.

2018-01-01

A mathematical model for calculating the distribution of temperature and the dynamics of the phase transfor-mations of water in multilayer systems on permafrost-zone surface is proposed. The model allows one to perform calculations in the annual cycle, taking into account the distribution of temperature on the surface in warm and cold seasons. A system involving four layers, a snow or land cover, a top layer of soil, a layer of thermal-insulation materi-al, and a mineral soil, is analyzed. The calculations by the model allow one to choose the optimal thickness and com-position of the layers which would ensure the stability of structures built on the permafrost-zone surface.

Polarization fatigue of organic ferroelectric capacitors

PubMed Central

Zhao, Dong; Katsouras, Ilias; Li, Mengyuan; Asadi, Kamal; Tsurumi, Junto; Glasser, Gunnar; Takeya, Jun; Blom, Paul W. M.; de Leeuw, Dago M.

2014-01-01

The polarization of the ferroelectric polymer P(VDF-TrFE) decreases upon prolonged cycling. Understanding of this fatigue behavior is of great technological importance for the implementation of P(VDF-TrFE) in random-access memories. However, the origin of fatigue is still ambiguous. Here we investigate fatigue in thin-film capacitors by systematically varying the frequency and amplitude of the driving waveform. We show that the fatigue is due to delamination of the top electrode. The origin is accumulation of gases, expelled from the capacitor, under the impermeable top electrode. The gases are formed by electron-induced phase decomposition of P(VDF-TrFE), similar as reported for inorganic ferroelectric materials. When the gas barrier is removed and the waveform is adapted, a fatigue-free ferroelectric capacitor based on P(VDF-TrFE) is realized. The capacitor can be cycled for more than 108 times, approaching the programming cycle endurance of its inorganic ferroelectric counterparts. PMID:24861542

Managed Development Environment Successes for MSFC's VIPA Team

NASA Technical Reports Server (NTRS)

Finckenor, Jeff; Corder, Gary; Owens, James; Meehan, Jim; Tidwell, Paul H.

2005-01-01

This paper outlines the best practices of the Vehicle Design Team for VIPA. The functions of the VIPA Vehicle Design (VVD) discipline team are to maintain the controlled reference geometry and provide linked, simplified geometry for each of the other discipline analyses. The core of the VVD work, and the approach for VVD s first task of controlling the reference geometry, involves systems engineering, top-down, layout-based CAD modeling within a Product Data Manager (PDM) development environment. The top- down approach allows for simple control of very large, integrated assemblies and greatly enhances the ability to generate trade configurations and reuse data. The second VVD task, model simplification for analysis, is handled within the managed environment through application of the master model concept. In this approach, there is a single controlling, or master, product definition dataset. Connected to this master model are reference datasets with live geometric and expression links. The referenced models can be for drawings, manufacturing, visualization, embedded analysis, or analysis simplification. A discussion of web based interaction, including visualization, between the design and other disciplines is included. Demonstrated examples are cited, including the Space Launch Initiative development cycle, the Saturn V systems integration and verification cycle, an Orbital Space Plane study, and NASA Exploration Office studies of Shuttle derived and clean sheet launch vehicles. The VIPA Team has brought an immense amount of detailed data to bear on program issues. A central piece of that success has been the Managed Development Environment and the VVD Team approach to modeling.

Project Interface Requirements Process Including Shuttle Lessons Learned

NASA Technical Reports Server (NTRS)

Bauch, Garland T.

2010-01-01

Most failures occur at interfaces between organizations and hardware. Processing interface requirements at the start of a project life cycle will reduce the likelihood of costly interface changes/failures later. This can be done by adding Interface Control Documents (ICDs) to the Project top level drawing tree, providing technical direction to the Projects for interface requirements, and by funding the interface requirements function directly from the Project Manager's office. The interface requirements function within the Project Systems Engineering and Integration (SE&I) Office would work in-line with the project element design engineers early in the life cycle to enhance communications and negotiate technical issues between the elements. This function would work as the technical arm of the Project Manager to help ensure that the Project cost, schedule, and risk objectives can be met during the Life Cycle. Some ICD Lessons Learned during the Space Shuttle Program (SSP) Life Cycle will include the use of hardware interface photos in the ICD, progressive life cycle design certification by analysis, test, & operations experience, assigning interface design engineers to Element Interface (EI) and Project technical panels, and linking interface design drawings with project build drawings

Lifting the Markov blankets of socio-cultural evolution. A comment on "Answering Schrödinger's question: A free-energy formulation" by Maxwell James Désormeau Ramstead et al.

NASA Astrophysics Data System (ADS)

Leydesdorff, Loet

2018-03-01

Ramstead et al. [8] claim an encompassing ontology which can be used as a heuristics for studying life, mind, and society both empirically and in terms of computer simulations. The systems levels are self-organizing into a hierarchy; "Markov blankets" close the various levels for one another. Homo sapiens sapiens is placed at the top of this hierarchy as "the world's most complex living systems." Humans are said to generate "(epi)genetically-specified expectations that have been shaped by selection to guide action-perception cycles toward adaptive or unsurprising states."

Cell module and fuel conditioner development

NASA Technical Reports Server (NTRS)

Feret, J. M.

1981-01-01

A phosphoric acid fuel cell (PAFC) stack design having a 10 kW power rating for operation at higher than atmospheric pressure based on the existing Mark II design configuration is described. Functional analysis, trade studies and thermodynamic cycle analysis for requirements definition and system operating parameter selection purposes were performed. Fuel cell materials and components, and performance testing and evaluation of the repeating electrode components were characterized. The state of the art manufacturing technology for all fuel cell components and the fabrication of short stacks of various sites were established. A 10 kW PAFC stack design for higher pressure operation utilizing the top down systems engineering aproach was developed.

Optimization of wave rotors for use as gas turbine engine topping cycles

NASA Technical Reports Server (NTRS)

Wilson, Jack; Paxson, Daniel E.

1995-01-01

Use of a wave rotor as a topping cycle for a gas turbine engine can improve specific power and reduce specific fuel consumption. Maximum improvement requires the wave rotor to be optimized for best performance at the mass flow of the engine. The optimization is a trade-off between losses due to friction and passage opening time, and rotational effects. An experimentally validated, one-dimensional CFD code, which includes these effects, has been used to calculate wave rotor performance, and find the optimum configuration. The technique is described, and results given for wave rotors sized for engines with sea level mass flows of 4, 26, and 400 lb/sec.

The impact of land use on carbon and climate in the preindustrial Holocene: What have we learned and what are the priorities for future research?

NASA Astrophysics Data System (ADS)

Ellis, E. C.; Kaplan, J. O.

2015-12-01

Did humans affect global climate over the before the Industrial Era? While this question is hotly debated, the co-evolution of humans and the natural environment over the last 11,700 years had an undisputed role in influencing the development and present state of terrestrial ecosystems. Yet we still have a very incomplete picture of human-environment interactions over the Holocene. In order to address this lack of understanding, both bottom-up and top-down approaches have been used to reconstruct past human impact on the global carbon cycle and climate. Top-down approaches rely on the analysis of the concentrations and isotopic signature of trace gases trapped in polar ice to identify human contributions to atmospheric composition. Bottom-up approaches combine historical and archaeological data to reconstruct land use, and using these reconstructions drive earth system models that simulate carbon cycling and climate. Recently a number of studies, both top-down and bottom-up, have shed new light on the role of land use influencing the carbon cycle and climate over the preindustrial Holocene. Ice core studies generally suggested that late Holocene CO2 was driven by natural fluctuations in climate and ocean circulation. The evidence from bottom-up studies is more nuanced. Most scenarios of Holocene anthropogenic land cover change (ALCC) tend to agree in the net magnitude of deforestation at AD 1850. But ALCC scenarios vary widely in the timing of deforestation over the course of the preindustrial Holocene. These differences lead to multiple plausible explanations to the atmospheric composition record, including scenarios that allow for a substantial amount of anthropogenic deforestation in preindustrial time. Uncertainty in our understanding of preindustrial ALCC also leads to large differences in the estimated importance of land use on climate earlier in the Holocene. For example, modelling experiments performed for Europe representing conditions at the peak of the Roman Empire show potentially large impacts of land use on regional climate. The wide variety of results gained so far from ALCC and climate modelling experiments shows that the question of "how much did humans influence the state of the Earth System before the Industrial Revolution?" is far from being resolved.

RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription.

PubMed

Baranello, Laura; Wojtowicz, Damian; Cui, Kairong; Devaiah, Ballachanda N; Chung, Hye-Jung; Chan-Salis, Ka Yim; Guha, Rajarshi; Wilson, Kelli; Zhang, Xiaohu; Zhang, Hongliang; Piotrowski, Jason; Thomas, Craig J; Singer, Dinah S; Pugh, B Franklin; Pommier, Yves; Przytycka, Teresa M; Kouzine, Fedor; Lewis, Brian A; Zhao, Keji; Levens, David

2016-04-07

We report a mechanism through which the transcription machinery directly controls topoisomerase 1 (TOP1) activity to adjust DNA topology throughout the transcription cycle. By comparing TOP1 occupancy using chromatin immunoprecipitation sequencing (ChIP-seq) versus TOP1 activity using topoisomerase 1 sequencing (TOP1-seq), a method reported here to map catalytically engaged TOP1, TOP1 bound at promoters was discovered to become fully active only after pause-release. This transition coupled the phosphorylation of the carboxyl-terminal-domain (CTD) of RNA polymerase II (RNAPII) with stimulation of TOP1 above its basal rate, enhancing its processivity. TOP1 stimulation is strongly dependent on the kinase activity of BRD4, a protein that phosphorylates Ser2-CTD and regulates RNAPII pause-release. Thus the coordinated action of BRD4 and TOP1 overcame the torsional stress opposing transcription as RNAPII commenced elongation but preserved negative supercoiling that assists promoter melting at start sites. This nexus between transcription and DNA topology promises to elicit new strategies to intercept pathological gene expression. Copyright © 2016 Elsevier Inc. All rights reserved.

V/STOL Tandem Fan transition section model test. [in the Lewis Research Center 10-by-10 foot wind tunnel

NASA Technical Reports Server (NTRS)

Simpkin, W. E.

1982-01-01

An approximately 0.25 scale model of the transition section of a tandem fan variable cycle engine nacelle was tested in the NASA Lewis Research Center 10-by-10 foot wind tunnel. Two 12-inch, tip-turbine driven fans were used to simulate a tandem fan engine. Three testing modes simulated a V/STOL tandem fan airplane. Parallel mode has two separate propulsion streams for maximum low speed performance. A front inlet, fan, and downward vectorable nozzle forms one stream. An auxilliary top inlet provides air to the aft fan - supplying the core engine and aft vectorable nozzle. Front nozzle and top inlet closure, and removal of a blocker door separating the two streams configures the tandem fan for series mode operations as a typical aircraft propulsion system. Transition mode operation is formed by intermediate settings of the front nozzle, blocker door, and top inlet. Emphasis was on the total pressure recovery and flow distortion at the aft fan face. A range of fan flow rates were tested at tunnel airspeeds from 0 to 240 knots, and angles-of-attack from -10 to 40 deg for all three modes. In addition to the model variables for the three modes, model variants of the top inlet were tested in the parallel mode only. These lip variables were: aft lip boundary layer bleed holes, and Three position turning vane. Also a bellmouth extension of the top inlet side lips was tested in parallel mode.

Glacioeustasy, meteoric diagenesis, and the carbon cycle during the Middle Carboniferous

NASA Astrophysics Data System (ADS)

Dyer, Blake; Maloof, Adam C.; Higgins, John A.

2015-10-01

Middle Carboniferous carbonates in the western U.S. have undergone Pleistocene Bahamas-style meteoric diagenesis that may be associated with expanding late Paleozoic ice sheets. Fourteen stratigraphic sections from carbonate platforms illustrate the regional distribution and variable intensity of physical and chemical diagenesis just below the Middle Carboniferous unconformity. These sections contain top-negative carbon isotope excursions that terminate in regional exposure surfaces that are associated with some combination of karst towers, desiccation cracks, fabric destructive recrystallization, or extensive root systems. The timing of the diagenesis is synchronous with similarly scaled top-negative carbon isotope excursions observed by others in England, Kazakhstan, and China. The mass flux of negative carbon required to generate similar isotopic profiles across the areal extent of Middle Carboniferous platform carbonates is a significant component of the global carbon cycle. We present a simple carbon box model to illustrate that the δ13C of dissolved inorganic carbon in the ocean could be elevated by ˜1.4‰ as isotopically light carbon from the weathering of terrestrial organic matter reacts with exposed platforms before reaching the ocean and atmosphere. These results represent an improvement on global biogeochemical models that have struggled to provide a congruent solution to the high δ13C of the late Paleozoic icehouse.

Numerical Assessment of Four-Port Through-Flow Wave Rotor Cycles with Passage Height Variation

NASA Technical Reports Server (NTRS)

Paxson, D. E.; Lindau, Jules W.

1997-01-01

The potential for improved performance of wave rotor cycles through the use of passage height variation is examined. A Quasi-one-dimensional CFD code with experimentally validated loss models is used to determine the flowfield in the wave rotor passages. Results indicate that a carefully chosen passage height profile can produce substantial performance gains. Numerical performance data are presented for a specific profile, in a four-port, through-flow cycle design which yielded a computed 4.6% increase in design point pressure ratio over a comparably sized rotor with constant passage height. In a small gas turbine topping cycle application, this increased pressure ratio would reduce specific fuel consumption to 22% below the un-topped engine; a significant improvement over the already impressive 18% reductions predicted for the constant passage height rotor. The simulation code is briefly described. The method used to obtain rotor passage height profiles with enhanced performance is presented. Design and off-design results are shown using two different computational techniques. The paper concludes with some recommendations for further work.

The study of operating an air conditioning system using Maisotsenko-Cycle

NASA Astrophysics Data System (ADS)

Khan, Mohammad S.; Tahan, Sami; Toufic El-Achkar, Mohamad; Abou Jamus, Saleh

2018-03-01

The project aims to design and build an air conditioning system that runs on the Maisotsenko cycle. The system is required to condition and cool down ambient air for a small residential space with the reduction in the use of electricity and eliminating the use of commercial refrigerants. This project can operate at its optimum performance in remote areas like oil diggers and other projects that run in the desert or any site that would not have a very high relative humidity level. The Maisotsenko cycle is known as the thermodynamic concept that captures energy from the air by using the psychometric renewable energy available in the latent heat in water evaporating in air. The heat and mass exchanger design was based on choosing a material that would-be water resistant and breathable, which was found to be layers of cardboard placed on top of each other and thus creating channels for air to pass through. Aiming for this design eliminates any high power electrical equipment such as compressors, condensers and evaporators that would be used in an AC system with the exception of a 600 W blower and a 10 W fan, thus making it a more environmentally friendly project. Moreover, the project is limited by the ambient temperature and humidity, as the model operates at an optimum when the relative humidity is lower.

Physical subdivision and description of the water-bearing sediments of the Santa Clara Valley, California

USGS Publications Warehouse

Wentworth, Carl M.; Jachens, Robert C.; Williams, Robert A.; Tinsley, John C.; Hanson, Randall T.

2015-01-01

Maps and cross sections show the elevations of cycle boundaries and the underlying bedrock surface, the varying thicknesses of the cycles and of their fine tops and coarse bottoms, and the aggregate thickness of coarse layers in those bottom intervals. Coarse sediment is more abundant toward some parts of the basin margin and in the southern part of the basin. Cycle boundary surfaces are relatively smooth, and their shapes are consistent with having been intercycle topographic surfaces. The underlying bedrock surface has a relief of more than 1,200 feet and deepens toward the center of the basin and the west edge of the fault-bounded Evergreen Basin, which is concealed beneath the east side of the Quaternary basin. The absence of consistent abrupt changes in thicknesses or boundary elevations across the basin or in cross section indicates that the interior of the basin is largely unfaulted, with the Silver Creek strand of the San Andreas system at the west edge of the Evergreen Basin being the sole exception. The east and west margins of the Santa Clara Basin, in contrast, are marked by reverse and thrust fault systems.

A case study of the carbon footprint of milk from high-performing confinement and grass-based dairy farms.

PubMed

O'Brien, D; Capper, J L; Garnsworthy, P C; Grainger, C; Shalloo, L

2014-03-01

Life-cycle assessment (LCA) is the preferred methodology to assess carbon footprint per unit of milk. The objective of this case study was to apply an LCA method to compare carbon footprints of high-performance confinement and grass-based dairy farms. Physical performance data from research herds were used to quantify carbon footprints of a high-performance Irish grass-based dairy system and a top-performing United Kingdom (UK) confinement dairy system. For the US confinement dairy system, data from the top 5% of herds of a national database were used. Life-cycle assessment was applied using the same dairy farm greenhouse gas (GHG) model for all dairy systems. The model estimated all on- and off-farm GHG sources associated with dairy production until milk is sold from the farm in kilograms of carbon dioxide equivalents (CO2-eq) and allocated emissions between milk and meat. The carbon footprint of milk was calculated by expressing GHG emissions attributed to milk per tonne of energy-corrected milk (ECM). The comparison showed that when GHG emissions were only attributed to milk, the carbon footprint of milk from the Irish grass-based system (837 kg of CO2-eq/t of ECM) was 5% lower than the UK confinement system (884 kg of CO2-eq/t of ECM) and 7% lower than the US confinement system (898 kg of CO2-eq/t of ECM). However, without grassland carbon sequestration, the grass-based and confinement dairy systems had similar carbon footprints per tonne of ECM. Emission algorithms and allocation of GHG emissions between milk and meat also affected the relative difference and order of dairy system carbon footprints. For instance, depending on the method chosen to allocate emissions between milk and meat, the relative difference between the carbon footprints of grass-based and confinement dairy systems varied by 3 to 22%. This indicates that further harmonization of several aspects of the LCA methodology is required to compare carbon footprints of contrasting dairy systems. In comparison to recent reports that assess the carbon footprint of milk from average Irish, UK, and US dairy systems, this case study indicates that top-performing herds of the respective nations have carbon footprints 27 to 32% lower than average dairy systems. Although differences between studies are partly explained by methodological inconsistency, the comparison suggests that potential exists to reduce the carbon footprint of milk in each of the nations by implementing practices that improve productivity. Copyright © 2014 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants

PubMed Central

2011-01-01

Background Genetic alterations in human topoisomerase II alpha (TOP2A) are linked to cancer susceptibility. TOP2A decatenates chromosomes and thus is necessary for multiple aspects of cell division including DNA replication, chromosome condensation and segregation. Topoisomerase II alpha is also required for embryonic development in mammals, as mouse Top2a knockouts result in embryonic lethality as early as the 4-8 cell stage. The purpose of this study was to determine whether the extended developmental capability of zebrafish top2a mutants arises from maternal expression of top2a or compensation from its top2b paralogue. Results Here, we describe bloody minded (blm), a novel mutant of zebrafish top2a. In contrast to mouse Top2a nulls, zebrafish top2a mutants survive to larval stages (4-5 day post fertilization). Developmental analyses demonstrate abundant expression of maternal top2a but not top2b. Inhibition or poisoning of maternal topoisomerase II delays embryonic development by extending the cell cycle M-phase. Zygotic top2a and top2b are co-expressed in the zebrafish CNS, but endogenous or ectopic top2b RNA appear unable to prevent the blm phenotype. Conclusions We conclude that maternal top2a enables zebrafish development before the mid-zygotic transition (MZT) and that zebrafish top2a and top2b are not functionally redundant during development after activation of the zygotic genome. PMID:22111588

A Gigantic Jet Observed Over an Mesoscale Convective System in Midlatitude Region

NASA Astrophysics Data System (ADS)

Yang, Jing; Sato, Mitsuteru; Liu, Ningyu; Lu, Gaopeng; Wang, Yu; Wang, Zhichao

2018-01-01

Gigantic jets (GJs) are mostly observed over summer tropical or tropical-like thunderstorms. This study reports observation of a GJ over a mesoscale convective system (MCS) in the midlatitude region in eastern China. The GJ is observed over a relatively weak radar reflectivity region ahead of the leading line, and the maximum radar echo top along the GJ azimuth was lower than the tropopause in the same region, significantly different from past studies that indicate summer GJs are usually associated with convective surges or overshooting tops. Also different from most of previous observations showing GJ-producing summer thunderstorms only produced GJ type of transient luminous events during their life cycles, two sprites were also captured in a time window of 15 min containing the GJ, indicating that the MCS provides favorable conditions not only for the GJ but also for the sprites. The balloon-borne soundings of the MCS show that there were large wind shears in the middle and upper levels of the thundercloud, which may have played important roles for the GJ production.

Understanding reproducibility of human IVF traits to predict next IVF cycle outcome.

PubMed

Wu, Bin; Shi, Juanzi; Zhao, Wanqiu; Lu, Suzhen; Silva, Marta; Gelety, Timothy J

2014-10-01

Evaluating the failed IVF cycle often provides useful prognostic information. Before undergoing another attempt, patients experiencing an unsuccessful IVF cycle frequently request information about the probability of future success. Here, we introduced the concept of reproducibility and formulae to predict the next IVF cycle outcome. The experimental design was based on the retrospective review of IVF cycle data from 2006 to 2013 in two different IVF centers and statistical analysis. The reproducibility coefficients (r) of IVF traits including number of oocytes retrieved, oocyte maturity, fertilization, embryo quality and pregnancy were estimated using the interclass correlation coefficient between the repeated IVF cycle measurements for the same patient by variance component analysis. The formulae were designed to predict next IVF cycle outcome. The number of oocytes retrieved from patients and their fertilization rate had the highest reproducibility coefficients (r = 0.81 ~ 0.84), which indicated a very close correlation between the first retrieval cycle and subsequent IVF cycles. Oocyte maturity and number of top quality embryos had middle level reproducibility (r = 0.38 ~ 0.76) and pregnancy rate had a relative lower reproducibility (r = 0.23 ~ 0.27). Based on these parameters, the next outcome for these IVF traits might be accurately predicted by the designed formulae. The introduction of the concept of reproducibility to our human IVF program allows us to predict future IVF cycle outcomes. The traits of oocyte numbers retrieved, oocyte maturity, fertilization, and top quality embryos had higher or middle reproducibility, which provides a basis for accurate prediction of future IVF outcomes. Based on this prediction, physicians may counsel their patients or change patient's stimulation plans, and laboratory embryologists may improve their IVF techniques accordingly.

TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells

PubMed Central

Pedersen, Rune Troelsgaard; Kruse, Thomas; Nilsson, Jakob

2015-01-01

Genome integrity is critically dependent on timely DNA replication and accurate chromosome segregation. Replication stress delays replication into G2/M, which in turn impairs proper chromosome segregation and inflicts DNA damage on the daughter cells. Here we show that TopBP1 forms foci upon mitotic entry. In early mitosis, TopBP1 marks sites of and promotes unscheduled DNA synthesis. Moreover, TopBP1 is required for focus formation of the structure-selective nuclease and scaffold protein SLX4 in mitosis. Persistent TopBP1 foci transition into 53BP1 nuclear bodies (NBs) in G1 and precise temporal depletion of TopBP1 just before mitotic entry induced formation of 53BP1 NBs in the next cell cycle, showing that TopBP1 acts to reduce transmission of DNA damage to G1 daughter cells. Based on these results, we propose that TopBP1 maintains genome integrity in mitosis by controlling chromatin recruitment of SLX4 and by facilitating unscheduled DNA synthesis. PMID:26283799

Corrosion/Erosion Behavior of Silicon Nitride and Silicon Carbide Ceramics - Gas Turbine Experience

DTIC Science & Technology

1979-04-01

C-0138. As part of a program to utilize ceramics in helical expander Brayton cycle turbomachines for coal-fired topping cycles, Myers el a1.7 have...Meyers et al., Reference 7). 7. MEYERS, B., LANDINGHAM, R., MOHR, P., and TAYLOR , K. An Adiabatic Coal-Fired 1350 C Expander in Proceedings: Workshop on

Fuel cell-gas turbine hybrid system design part II: Dynamics and control

NASA Astrophysics Data System (ADS)

McLarty, Dustin; Brouwer, Jack; Samuelsen, Scott

2014-05-01

Fuel cell gas turbine hybrid systems have achieved ultra-high efficiency and ultra-low emissions at small scales, but have yet to demonstrate effective dynamic responsiveness or base-load cost savings. Fuel cell systems and hybrid prototypes have not utilized controls to address thermal cycling during load following operation, and have thus been relegated to the less valuable base-load and peak shaving power market. Additionally, pressurized hybrid topping cycles have exhibited increased stall/surge characteristics particularly during off-design operation. This paper evaluates additional control actuators with simple control methods capable of mitigating spatial temperature variation and stall/surge risk during load following operation of hybrid fuel cell systems. The novel use of detailed, spatially resolved, physical fuel cell and turbine models in an integrated system simulation enables the development and evaluation of these additional control methods. It is shown that the hybrid system can achieve greater dynamic response over a larger operating envelope than either individual sub-system; the fuel cell or gas turbine. Results indicate that a combined feed-forward, P-I and cascade control strategy is capable of handling moderate perturbations and achieving a 2:1 (MCFC) or 4:1 (SOFC) turndown ratio while retaining >65% fuel-to-electricity efficiency, while maintaining an acceptable stack temperature profile and stall/surge margin.

Geostationary earth climate sensor: Scientific utility and feasibility, phase A

NASA Technical Reports Server (NTRS)

Campbell, G. Garrett; Vonderharr, T. H.; Evert, T.; Kidder, Stanley Q.; Purdom, James F. W.

1991-01-01

The possibility of accurate broad band radiation budget measurements from a GEO platform will provide a unique opportunity for viewing radiation processes in the atmosphere-ocean system. The CSU/TRW team has prepared a Phase 1 instrument design study demonstrating that measurements of radiation budget are practical from geosynchronous orbit with proven technology. This instrument concept is the Geostationary Earth Climate Sensor (GECS). A range of resolutions down to 20 km at the top of the atmosphere are possible, depending upon the scientific goals of the experiment. These tradeoffs of resolution and measurement repeat cycles are examined for scientific utility. The design of a flexible instrument is shown to be possible to meet the two goals: long-term, systematic monitoring of the diurnal cycles of radiation budget; and high time and space resolution studies of regional radiation features.

Design concept of a cryogenic distillation column cascade for a ITER scale fusion reactor

NASA Astrophysics Data System (ADS)

Yamanishi, Toshihiko; Enoeda, Mikio; Okuno, Kenji

1994-07-01

A column cascade has been proposed for the fuel cycle of a ITER scale fusion reactor. The proposed cascade consists of three columns and has significant features: either top or bottom product is prior to the other for each column; it is avoided to withdraw side streams as products or feeds of down stream columns; and there is no recycle steam between the columns. In addition, the product purity of the cascade can be maintained against the changes of flow rates and compositions of feed streams just by adjusting the top and bottom flow rates. The control system has been designed for each column in the cascade. A key component in the prior product stream was selected, and the analysis method of this key component was proposed. The designed control system never brings instability as long as the concentration of the key component is measured with negligible time lag. The time lag for the measurement considerably affects the stability of the control system. A significant conclusion by the simulation in this work is that permissible time for the measurement is about 0.5 hour to obtain stable control. Hence, the analysis system using the gas chromatography is valid for control of the columns.

Environmental analysis of the logistics of agricultural products from roof top greenhouses in Mediterranean urban areas.

PubMed

Sanyé-Mengual, Esther; Cerón-Palma, Ileana; Oliver-Solà, Jordi; Montero, Juan Ignacio; Rieradevall, Joan

2013-01-15

As urban populations increase so does the amount of food transported to cities worldwide, and innovative agro-urban systems are being developed to integrate agricultural production into buildings; for example, by using roof top greenhouses (RTGs). This paper aims to quantify and compare, through a life cycle assessment, the environmental impact of the current linear supply system with a RTG system by using a case study for the production of tomatoes. The main results indicate that a change from the current linear system to the RTG system could result in a reduction, per kilogram of tomatoes (the functional unit), in the range of 44.4-75.5% for the different impact categories analysed, and savings of up to 73.5% in energy requirements. These savings are associated with re-utilisation of packaging systems (55.4-85.2%), minimisation of transport requirements (7.6-15.6%) and reduction of the loss of product during transportation and retail stages (7.3-37%). The RTG may become a strategic factor in the design of low-carbon cities in Mediterranean areas. Short-term implementation in the city of Barcelona could result in savings of 66.1 tonnes of CO₂ eq. ha(-1) when considering the global warming potential, and of 71.03 t ha(-1) when considering that the transformation from woodland to agricultural land is avoided. Copyright © 2012 Society of Chemical Industry.

Vial freeze-drying, part 1: new insights into heat transfer characteristics of tubing and molded vials.

PubMed

Hibler, Susanne; Wagner, Christophe; Gieseler, Henning

2012-03-01

In order to optimize a freeze-drying cycle, information regarding the heat transfer characteristics of the container system is imperative. Two most recently developed tubing (TopLyo™) and molded (EasyLyo™) vial designs were compared with a standard serum tubing and molded vial, a polymer vial (TopPac™), and an amber molded EasyLyo™. In addition, the impact of methodology on the determination of reliable vial heat transfer coefficient (K(v) ) data is examined in detail. All K(v) s were gravimetrically determined by sublimation tests with pure water at 50, 100, 200, and 400 mTorr. In contrast to the traditional assumption that molded vials exhibit inefficient heat transfer characteristics, these vials showed a very similar performance compared with their serum tubing counterparts in the relevant pressure range for freeze-drying. At 100 mTorr, the TopLyo™ center vials show only 4% higher K(v) values than the EasyLyo™ center vials. All glass vials outmatch the polymer vial in terms of heat transfer, up to 30% elevated heat transfer for the TopLyo™ center vials at 400 mTorr. Sublimation tests have demonstrated to be a valuable tool to investigate the heat transfer characteristics of vials, but results are dependent on methodology. New developments in molded vial manufacturing lead to improved heat transfer performance. Copyright © 2011 Wiley Periodicals, Inc.

Semantic Data Integration and Ontology Use within the Global Earth Observation System of Systems (GEOSS) Global Water Cycle Data Integration System

NASA Astrophysics Data System (ADS)

Pozzi, W.; Fekete, B.; Piasecki, M.; McGuinness, D.; Fox, P.; Lawford, R.; Vorosmarty, C.; Houser, P.; Imam, B.

2008-12-01

The inadequacies of water cycle observations for monitoring long-term changes in the global water system, as well as their feedback into the climate system, poses a major constraint on sustainable development of water resources and improvement of water management practices. Hence, The Group on Earth Observations (GEO) has established Task WA-08-01, "Integration of in situ and satellite data for water cycle monitoring," an integrative initiative combining different types of satellite and in situ observations related to key variables of the water cycle with model outputs for improved accuracy and global coverage. This presentation proposes development of the Rapid, Integrated Monitoring System for the Water Cycle (Global-RIMS)--already employed by the GEO Global Terrestrial Network for Hydrology (GTN-H)--as either one of the main components or linked with the Asian system to constitute the modeling system of GEOSS for water cycle monitoring. We further propose expanded, augmented capability to run multiple grids to embrace some of the heterogeneous methods and formats of the Earth Science, Hydrology, and Hydraulic Engineering communities. Different methodologies are employed by the Earth Science (land surface modeling), the Hydrological (GIS), and the Hydraulic Engineering Communities; with each community employing models that require different input data. Data will be routed as input variables to the models through web services, allowing satellite and in situ data to be integrated together within the modeling framework. Semantic data integration will provide the automation to enable this system to operate in near-real-time. Multiple data collections for ground water, precipitation, soil moisture satellite data, such as SMAP, and lake data will require multiple low level ontologies, and an upper level ontology will permit user-friendly water management knowledge to be synthesized. These ontologies will have to have overlapping terms mapped and linked together. so that they can cover an even wider net of data sources. The goal is to develop the means to link together the upper level and lower level ontologies and to have these registered within the GEOSS Registry. Actual operational ontologies that would link to models or link to data collections containing input variables required by models would have to be nested underneath this top level ontology, analogous to the mapping that has been carried out among ontologies within GEON.

A kinetic clutch governs uncoiling by type IB topoisomerases

NASA Astrophysics Data System (ADS)

Neuman, Keir

2013-03-01

Type IB topoisomerases (Top1B) are essential enzymes that relax excessive DNA supercoiling associated with replication and transcription and are important drug targets for cancer chemotherapy. The natural compound camptothecin (CPT) and the cancer chemotherapeutics derived from it, irinotecan and topotecan, are highly specific inhibitors of human nuclear Type IB topoisomerase (nTop1). We employed a magnetic-tweezers based single-molecule DNA supercoil relaxation assay to measure the torque dependence of human nuclear Top1 relaxation (nTop1) and inhibition by CPT. For comparison, we examined the human mitochondrial (Top1mt) topoisomerase and an N-terminal deletion mutant of nTop1 (Top68). Despite substantial sequence homology in their core domains, nTop1 and Top1mt exhibit dramatic differences in sensitivity to torque and CPT, with Top68 betraying intermediate characteristics. In particular, nTop1 displays nearly torque-independent religation probability, distinguishing it from other Top1B enzymes studied to date. Kinetic modeling reveals a hitherto unobserved torque-independent transition linking the DNA rotation and religation phases of the enzymatic cycle. The parameters of this transition determine the torque sensitivity of religation, and the efficiency of CPT binding. This ``kinetic clutch'' mechanism explains the molecular basis of CPT sensitivity and more generally provides a framework with which to interpret Top1B activity and inhibition.

Analysis of the Diurnal Cycle of Precipitation and its Relation to Cloud Radiative Forcing Using TRMM Products

NASA Technical Reports Server (NTRS)

Randall, David A.; Fowler, Laura D.; Lin, Xin

1998-01-01

In order to improve our understanding of the interactions between clouds, radiation, and the hydrological cycle simulated in the Colorado State University General Circulation Model (CSU GCM), we focused our research on the analysis of the diurnal cycle of precipitation, top-of-the-atmosphere and surface radiation budgets, and cloudiness using 10-year long Atmospheric Model Intercomparison Project (AMIP) simulations. Comparisons the simulated diurnal cycle were made against the diurnal cycle of Earth Radiation Budget Experiment (ERBE) radiation budget and International Satellite Cloud Climatology Project (ISCCP) cloud products. This report summarizes our major findings over the Amazon Basin.

Field-cycling NMR experiments in an ultra-wide magnetic field range: relaxation and coherent polarization transfer.

PubMed

Zhukov, Ivan V; Kiryutin, Alexey S; Yurkovskaya, Alexandra V; Grishin, Yuri A; Vieth, Hans-Martin; Ivanov, Konstantin L

2018-05-09

An experimental method is described allowing fast field-cycling Nuclear Magnetic Resonance (NMR) experiments over a wide range of magnetic fields from 5 nT to 10 T. The method makes use of a hybrid technique: the high field range is covered by positioning the sample in the inhomogeneous stray field of the NMR spectrometer magnet. For fields below 2 mT a magnetic shield is mounted on top of the spectrometer; inside the shield the magnetic field is controlled by a specially designed coil system. This combination allows us to measure T1-relaxation times and nuclear Overhauser effect parameters over the full range in a routine way. For coupled proton-carbon spin systems relaxation with a common T1 is found at low fields, where the spins are "strongly coupled". In some cases, experiments at ultralow fields provide access to heteronuclear long-lived spin states. Efficient coherent polarization transfer is seen for proton-carbon spin systems at ultralow fields as follows from the observation of quantum oscillations in the polarization evolution. Applications to analysis and the manipulation of heteronuclear spin systems are discussed.

Eruption cycles in a basaltic andesite system: insights from numerical modeling

NASA Astrophysics Data System (ADS)

Smekens, J. F.; Clarke, A. B.; De'Michieli Vitturi, M.

2015-12-01

Persistently active explosive volcanoes are characterized by short explosive bursts, which often occur at periodic intervals numerous times per day, spanning years to decades. Many of these systems present relatively evolved compositions (andesite to rhyolite), and their cyclic activity has been the subject of extensive work (e.g., Soufriere Hills Volcano, Montserrat). However, the same periodic behavior can also be observed at open systems of more mafic compositions, such as Semeru in Indonesia or Karymsky in Kamchatka for example. In this work, we use DOMEFLOW, a 1D transient numerical model of magma ascent, to identify the conditions that lead to and control periodic eruptions in basaltic andesite systems, where the viscosity of the liquid phase can be drastically lower. Periodic behavior occurs for a very narrow range of conditions, for which the mass balance between magma flux and open-system gas escape repeatedly generates a viscous plug, pressurizes the magma beneath the plug, and then explosively disrupts it. The characteristic timescale and magnitude of the eruptive cycles are controlled by the overall viscosity of the magmatic mixture, with higher viscosities leading to longer cycles and lower flow rates at the top of the conduit. Cyclic eruptions in basaltic andesite systems are observed for higher crystal contents, smaller conduit radii, and over a wider range of chamber pressures than the andesitic system, all of which are the direct consequence of a decrease in viscosity of the melt phase, and in turn in the intensity of the viscous forces generated by the system. Results suggest that periodicity can exist in more mafic systems with relatively lower chamber pressures than andesite and rhyolite systems, and may explain why more mafic magmas sometimes remain active for decades.

Evaluation of double-layer density modulated Si thin films as Li-ion battery anodes

NASA Astrophysics Data System (ADS)

Taha Demirkan, Muhammed; Yurukcu, Mesut; Dursun, Burcu; Demir-Cakan, Rezan; Karabacak, Tansel

2017-10-01

Double-layer density modulated silicon thin films which contain alternating low and high density Si film layers were fabricated by magnetron sputtering. Two different samples consisting of alternating layers of high-density/low-density and low-density/high-density Si thin film layers were investigated as anode electrodes in Li-ion batteries. Si thin film in which the terminating layer at the top is low density Si layer-quoted as low-density/high-density film (LD/HD)- exhibits better performance than Si thin film that has high density layer at the top, -quoted as high-density/low-density (HD/LD). A highly stabilized cycling performance with the specific charge capacities of 2000 mAh g-1 at the 150th cycle at C/2 current density, and 1200 mAh g-1 at the 240th cycle at 10 C current density were observed for the LD/HD Si anode in the presence of fluoroethylene carbonate (FEC) electrolyte additive.

Top-Down Strategy to Synthesize Mesoporous Dual Carbon Armored MnO Nanoparticles for Lithium-Ion Battery Anodes.

PubMed

Zhang, Wei; Li, Jiannian; Zhang, Jie; Sheng, Jinzhi; He, Ting; Tian, Meiyue; Zhao, Yufeng; Xie, Changjun; Mai, Liqiang; Mu, Shichun

2017-04-12

To overcome inferior rate capability and cycle stability of MnO-based materials as a lithium-ion battery anode associated with the pulverization and gradual aggregation during the conversion process, we constructed robust mesoporous N-doped carbon (N-C) protected MnO nanoparticles on reduced graphene oxide (rGO) (MnO@N-C/rGO) by a simple top-down incorporation strategy. Such dual carbon protection endows MnO@N-C/rGO with excellent structural stability and enhanced charge transfer kinetics. At 100 mA g -1 , it exhibits superior rate capability as high as 864.7 mAh g -1 , undergoing the deep charge/discharge for 70 cycles and outstanding cyclic stability (after 1300 cyclic tests at 2000 mA g -1 ; 425.0 mAh g -1 remains, accompanying merely 0.004% capacity decay per cycle). This facile method provides a novel strategy for synthesis of porous electrodes by making use of highly insulating materials.

Effect of coating thickness on microstructure and low temperature cyclic thermal fatigue behavior of thermal barrier coating (Al2O3)

NASA Astrophysics Data System (ADS)

Verma, Vijay; Patel, Sachin; Swarnkar, Vikas; K, Rajput S.

2018-03-01

Effect of coating thickness on low temperature cyclic thermal fatigue behaviour of Al2O3 thermal barrier coating (TBC) was concluded through the cyclic furnace thermal fatigue test (CFTF). Detonation gun (Thermal Spray) process was used for bond coating of NiCr and top coating of Al2O3 on Aluminium Alloy 6061 substrate. Top coating was done at two level of thickness to investigate the effect of coating thickness on low temperature cyclic thermal fatigue. The top coat of thickness 100μm-150μm was considered as thin TBC while the top coat of thickness 250μm-300μm was considered as thick TBC. The thickness of bond coat was taken as 120μm constant for both level of Al2O3 top coating. During CFTF test appearance of any crack on coated surface was adapted as main criterion of coating failure. Crack initiation was observed at edges and corner of thin thermal barrier coating after 60 number of thermal fatigue cycles while in case of thick thermal barrier coating these crack initiation was observed after 72 cycles of cyclic thermal fatigue test. During the study, it was observed that thick thermal barrier coating survived for long duration in comparison of thin TBC. Hence it can be concluded that application of thick TBC is more favourable to improve thermal durability of any component.

Population Change as Related to Long-Term Cycles in Residential Construction in the United States.

DTIC Science & Technology

1981-03-01

Research Paper Long-Term Cycles FPL 392 March 1 in Residential Construction in the United States , mllmill - -N ABSTRACT Major demographic changes have...ferent from what they are now. This paper analyzes the potential impact of changing population growth rates and the age structure of the population...United StatesPuiChangeDepartment of AgriculturePo ua inCng Forest Service Forest Lrouato as Related toP ductsLaboratory, Research Paper LongnTerm Cycles

Systems-Wide Analysis of Acclimation Responses to Long-Term Heat Stress and Recovery in the Photosynthetic Model Organism Chlamydomonas reinhardtii[W][OPEN

PubMed Central

Hemme, Dorothea; Veyel, Daniel; Mühlhaus, Timo; Sommer, Frederik; Jüppner, Jessica; Unger, Ann-Katrin; Sandmann, Michael; Fehrle, Ines; Schönfelder, Stephanie; Steup, Martin; Geimer, Stefan; Kopka, Joachim; Giavalisco, Patrick; Schroda, Michael

2014-01-01

We applied a top-down systems biology approach to understand how Chlamydomonas reinhardtii acclimates to long-term heat stress (HS) and recovers from it. For this, we shifted cells from 25 to 42°C for 24 h and back to 25°C for ≥8 h and monitored abundances of 1856 proteins/protein groups, 99 polar and 185 lipophilic metabolites, and cytological and photosynthesis parameters. Our data indicate that acclimation of Chlamydomonas to long-term HS consists of a temporally ordered, orchestrated implementation of response elements at various system levels. These comprise (1) cell cycle arrest; (2) catabolism of larger molecules to generate compounds with roles in stress protection; (3) accumulation of molecular chaperones to restore protein homeostasis together with compatible solutes; (4) redirection of photosynthetic energy and reducing power from the Calvin cycle to the de novo synthesis of saturated fatty acids to replace polyunsaturated ones in membrane lipids, which are deposited in lipid bodies; and (5) when sinks for photosynthetic energy and reducing power are depleted, resumption of Calvin cycle activity associated with increased photorespiration, accumulation of reactive oxygen species scavengers, and throttling of linear electron flow by antenna uncoupling. During recovery from HS, cells appear to focus on processes allowing rapid resumption of growth rather than restoring pre-HS conditions. PMID:25415976

Reducing dislocations in semiconductors utilizing repeated thermal cycling during multistage epitaxial growth

DOEpatents

Fan, John C. C.; Tsaur, Bor-Yeu; Gale, Ronald P.; Davis, Frances M.

1992-02-25

Dislocation densities are reduced in growing semiconductors from the vapor phase by employing a technique of interrupting growth, cooling the layer so far deposited, and then repeating the process until a high quality active top layer is achieved. The method of interrupted growth, coupled with thermal cycling, permits dislocations to be trapped in the initial stages of epitaxial growth.

Reducing dislocations in semiconductors utilizing repeated thermal cycling during multistage epitaxial growth

DOEpatents

Fan, John C. C.; Tsaur, Bor-Yeu; Gale, Ronald P.; Davis, Frances M.

1986-12-30

Dislocation densities are reduced in growing semiconductors from the vapor phase by employing a technique of interrupting growth, cooling the layer so far deposited, and then repeating the process until a high quality active top layer is achieved. The method of interrupted growth, coupled with thermal cycling, permits dislocations to be trapped in the initial stages of epitaxial growth.

Calcein represses human papillomavirus 16 E1-E2 mediated DNA replication via blocking their binding to the viral origin of replication.

PubMed

Das, Dipon; Smith, Nathan W; Wang, Xu; Richardson, Stacie L; Hartman, Matthew C T; Morgan, Iain M

2017-08-01

Human papillomaviruses are causative agents in several human diseases ranging from genital warts to ano-genital and oropharyngeal cancers. Currently only symptoms of HPV induced disease are treated; there are no antivirals available that directly target the viral life cycle. Previously, we determined that the cellular protein TopBP1 interacts with the HPV16 replication/transcription factor E2. This E2-TopBP1 interaction is essential for optimal E1-E2 DNA replication and for the viral life cycle. The drug calcein disrupts the interaction of TopBP1 with itself and other host proteins to promote cell death. Here we demonstrate that calcein blocks HPV16 E1-E2 DNA replication via blocking the viral replication complex forming at the origin of replication. This occurs at non-toxic levels of calcein and demonstrates specificity as it does not block the ability of E2 to regulate transcription. We propose that calcein or derivatives could be developed as an anti-HPV therapeutic. Copyright © 2017 Elsevier Inc. All rights reserved.

Thermodynamic Study of Multi Pressure HRSG in Gas/Steam Combined Cycle Power Plant

NASA Astrophysics Data System (ADS)

Sharma, Meeta; Singh, Onkar

2018-01-01

Combined cycle power plants have a combination of gas based topping cycle and steam based bottoming cycle through the use of Heat Recovery Steam Generator (HRSG). These HRSG may be either of single pressure (SP) or dual pressure (DP) or multiple pressure type. Here in this study thermodynamic analysis is carried out for optimal performance of HRSG using different types of HRSG layout for combined cycle efficiency improvement. Performance of single pressure HRSG and dual pressure HRSG, utilized in gas/steam combined cycle is analyzed and presented here. In comparison to single pressure, dual pressure HRSG offers 10 to 15% higher reduction in stack temperature due to greater heat recovery and thus improved plant efficiency.

Thermomechanical piston pump development

NASA Technical Reports Server (NTRS)

Sabelman, E. E.

1971-01-01

A thermally powered reciprocating pump has been devised to replace or augment an electric pump for the transport of temperature-control fluid on the Thermoelectric Outer Planet Spacecraft (TOPS). The thermally powered pump operates cyclically by extracting heat energy from the fluid by means of a vapor-pressure expansion system and by using the heat to perform the mechanical work of pumping. A feasibility test unit has been constructed to provide an output of 7 cu in during a 10- to 100-second cycle. It operates with a fluid input temperature of 200 to 300 F and a heat sink temperature of 0 to 30 F.

Recycling of the High Valence States of Heme Proteins by Cysteine Residues of Thimet-Oligopeptidase

PubMed Central

Ferreira, Juliana C.; Icimoto, Marcelo Y.; Marcondes, Marcelo F.; Oliveira, Vitor; Nascimento, Otaciro R.; Nantes, Iseli L.

2013-01-01

The peptidolytic enzyme THIMET-oligopeptidase (TOP) is able to act as a reducing agent in the peroxidase cycle of myoglobin (Mb) and horseradish peroxidase (HRP). The TOP-promoted recycling of the high valence states of the peroxidases to the respective resting form was accompanied by a significant decrease in the thiol content of the peptidolytic enzyme. EPR (electron paramagnetic resonance) analysis using DBNBS spin trapping revealed that TOP also prevented the formation of tryptophanyl radical in Mb challenged by H2O2. The oxidation of TOP thiol groups by peroxidases did not promote the inactivating oligomerization observed in the oxidation promoted by the enzyme aging. These findings are discussed towards a possible occurrence of these reactions in cells. PMID:24223886

Diagnosing and Assessing Uncertainties of the Carbon Cycle in Terrestrial Ecosystem Models from a Multi-Model Ensemble Experiment

NASA Astrophysics Data System (ADS)

Wang, W.; Dungan, J. L.; Hashimoto, H.; Michaelis, A.; Milesi, C.; Ichii, K.; Nemani, R. R.

2009-12-01

We are conducting an ensemble modeling exercise using the Terrestrial Observation and Prediction System (TOPS) to characterize structural uncertainty in carbon fluxes and stocks estimates from different ecosystem models. The experiment uses public-domain versions of Biome-BGC, LPJ, TOPS-BGC, and CASA, driven by a consistent set of climate fields for North America at 8km resolution and daily/monthly time steps over the period of 1982-2006. A set of diagnostics is developed to characterize the behavior of the models in the climate (temperature-precipitation) space, and to evaluate the simulated carbon cycle in an integrated way. The key findings of this study include that: (relative) optimal primary production is generally found in climate regions where the relationship between annual temperature (T, oC) and precipitation (P, mm) is defined by P = 50*T+500; the ratios between NPP and GPP are close to 50% on average, yet can vary between models and in different climate regions; the allocation of carbon to leaf growth represents a positive feedback to the primary production, and different approaches to constrain this process have significant impacts on the simulated carbon cycle; substantial differences in biomass stocks may be induced by small differences in the tissue turnover rate and the plant mortality; the mean residence time of soil carbon pools is strongly influenced by schemes of temperature regulations; non-respiratory disturbances (e.g., fires) are the main driver for NEP, yet its magnitudes vary between models. Overall, these findings indicate that although the structures of the models are similar, the uncertainties among them can be large, highlighting the problem inherent in relying on only one modeling approach to map surface carbon fluxes or to assess vegetation-climate interactions.

Conceptual Model-Based Systems Biology: Mapping Knowledge and Discovering Gaps in the mRNA Transcription Cycle

PubMed Central

Somekh, Judith; Choder, Mordechai; Dori, Dov

2012-01-01

We propose a Conceptual Model-based Systems Biology framework for qualitative modeling, executing, and eliciting knowledge gaps in molecular biology systems. The framework is an adaptation of Object-Process Methodology (OPM), a graphical and textual executable modeling language. OPM enables concurrent representation of the system's structure—the objects that comprise the system, and behavior—how processes transform objects over time. Applying a top-down approach of recursively zooming into processes, we model a case in point—the mRNA transcription cycle. Starting with this high level cell function, we model increasingly detailed processes along with participating objects. Our modeling approach is capable of modeling molecular processes such as complex formation, localization and trafficking, molecular binding, enzymatic stimulation, and environmental intervention. At the lowest level, similar to the Gene Ontology, all biological processes boil down to three basic molecular functions: catalysis, binding/dissociation, and transporting. During modeling and execution of the mRNA transcription model, we discovered knowledge gaps, which we present and classify into various types. We also show how model execution enhances a coherent model construction. Identification and pinpointing knowledge gaps is an important feature of the framework, as it suggests where research should focus and whether conjectures about uncertain mechanisms fit into the already verified model. PMID:23308089

MHD retrofit of steam power plants. Feasibility study. Summary and conclusions, Part I

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1979-07-01

The US Department of Energy Division of Magnetohydrodynamics (DOE/MHD) initiated this study to evaluate the feasibility of a retrofit option to reduce the time and cost of commercializing MHD. The MHD retrofit option will integrate a nominal 260 megawatt thermal (MWt) MHD topping cycle into an existing or scheduled private utility steam plant; this facility will test both the MHD system and the combined operation of the MHD/steam plant. The 260 MWt input level was determined to be the size which could most effectively demonstrate and verify the engineering design and operational characteristics of a coal-fired, open-cycle, MHD power plant.more » Details are presented. A goal of the MHD program is to have operational by the year 2003 a commercial size, fully integrated MHD plant. This would be accomplished by demonstrating commercial scale, baseload performance of a fully integrated, MHD/steam power plant. (WHK)« less

Microscale characterization of metallic coatings for a high strength high conductivity copper alloy

NASA Astrophysics Data System (ADS)

Jain, Piyush

NiCrAlY overlay coatings are being considered by NASA's Glenn Research Center to prevent blanching and reduce thermo-mechanical fatigue of rocket engine combustion chamber liners made of GRCop-84 (Cu-8%Cr-4%Nb) for reusable launch vehicles (RLVs). However, their successful application depends upon their integrity to the GRCop-84 during multiple firings of rocket engines. This study focuses on determining the adhesion of NiCrAlY coatings and their microstructural stability on GRCop-84 as a function of thermal cycling. Specimens were prepared by depositing NiCrAlY top coat on GRCop-84 by vacuum plasma spaying with a thin layer of Cu-26Cr as a bond coat. A thermal cycling rig was built to thermally cycle the NiCrAlY/Cu-26Cr/GRCop-84 specimens from RT to 600°C in an argon environment, with 10 minutes hold at 600°C, and 4 minutes hold at RT. Samples were cut from the coupons in as-received condition (AR), after 100 thermal cycles (TC-100), and after 300 thermal cycles (TC-300) for characterization. A newly developed interfacial microsample testing technique was employed to determine the adhesion of the coatings on GRCop-84, where bowtie shaped microsamples having interfaces normal to the tensile axis were tested. Interfacial microsamples of NiCrAlY/Cu-26Cr/GRCop-84 in all the conditions (AR, TC-100, and TC-300) failed cohesively in the substrate at a UTS of 380+/-5 MPa and their interfaces remained intact. The microstructural characterization revealed that microstructure of the NiCrAlY/Cu-26Cr/GRCop-84 specimens does not degrade as a function of thermal cycling. Constitutive properties of NiCrAlY, Cu-26Cr, and GRCop-84 were measured by testing monolithic samples and were used to build the finite element model (FEM) of the interfacial microsamples. The FE model analyzed the local stress-strain in the interfacial microsamples during the testing and confirmed the strength of the interfaces to be higher than 380+/-5 MPa. Depleted zones, devoid of Cr2Nb particles, were observed in the substrate near the interface, which has been attributed to uncontrolled processing parameters during the coating deposition. The interfacial microsamples containing depleted zones, failed at 335+/-25 MPa in AR condition exhibiting cohesive-adhesive failure, and at 360+/-15 MPa in TC-300 condition exhibiting adhesive failure. All these results suggested that the presence of depleted zone decreases the adhesion of the coating and should be avoided in future coatings deposition. Adhesion of two top coats, NiCrAlY (with the Cu-26Cr bond coat) and the Cu-26Cr (without any bond coat), were found to be lower on the grit blasted GRCop-84 than on the polished GRCop-84. The adhesion of both the top coats on polished GRCop-84 was measured to be 380+/-5 MPa with cohesive failure in the substrate, while the adhesion of NiCrAlY top coat on the grit blasted GRCop-84 was measured to be 142+/-35 MPa with cohesive failure in the Cu-26Cr bond coat, and the adhesion of Cu-26Cr top coat on the grit blasted GRCop-84 was measured to be 360+/-25 MPa with cohesive failure in the Cu-26Cr top coat. The microstructural characterization revealed that the reason of lower strength of top coats on the grit blasted GRCop-84 was the porosity present in the coatings on the grit blasted GRCop-84, while the coatings on the polished GRCop-84 did not have any measurable porosity.

Skylab 2 Solar Physics Experiment

NASA Technical Reports Server (NTRS)

1973-01-01

Skylab 2 Solar Physics Experiment. This black and white view of a solar flare was taken from the skylab remote solar experiment module mounted on top of the vehicle and worked automatically without any interaction from the crew. Solar flares or sunspots are eruptions on the sun's surface and appear to occur in cycles. When these cycles occur, there is worldwide electromagnetic interference affecting radio and television transmission.

Endurance and Cycle-to-cycle Uniformity Improvement in Tri-Layered CeO2/Ti/CeO2 Resistive Switching Devices by Changing Top Electrode Material

PubMed Central

Rana, Anwar Manzoor; Akbar, Tahira; Ismail, Muhammad; Ahmad, Ejaz; Hussain, Fayyaz; Talib, Ijaz; Imran, Muhammad; Mehmood, Khalid; Iqbal, Khalid; Nadeem, M. Younus

2017-01-01

Resistance switching characteristics of CeO2/Ti/CeO2 tri-layered films sandwiched between Pt bottom electrode and two different top electrodes (Ti and TaN) with different work functions have been investigated. RRAM memory cells composed of TaN/CeO2/Ti/CeO2/Pt reveal better resistive switching performance instead of Ti/CeO2/Ti/CeO2/Pt memory stacks. As compared to the Ti/CeO2 interface, much better ability of TaN/CeO2 interface to store and exchange plays a key role in the RS performance improvement, including lower forming/SET voltages, large memory window (~102) and no significant data degradation during endurance test of >104 switching cycles. The formation of TaON thinner interfacial layer between TaN TE and CeO2 film is found to be accountable for improved resistance switching behavior. Partial charge density of states is analyzed using density functional theory. It is found that the conductive filaments formed in CeO2 based devices is assisted by interstitial Ti dopant. Better stability and reproducibility in cycle-to-cycle (C2C) resistance distribution and Vset/Vreset uniformity were achieved due to the modulation of current conduction mechanism from Ohmic in low field region to Schottky emission in high field region. PMID:28079056

Thick solid electrolyte interphases grown on silicon nanocone anodes during slow cycling and their negative effects on the performance of Li-ion batteries.

PubMed

Luo, Fei; Chu, Geng; Xia, Xiaoxiang; Liu, Bonan; Zheng, Jieyun; Li, Junjie; Li, Hong; Gu, Changzhi; Chen, Liquan

2015-05-07

Thickness, homogeneity and coverage of the surface passivation layer on Si anodes for Li-ion batteries have decisive influences on their cyclic performance and coulombic efficiency, but related information is difficult to obtain, especially during cycling. In this work, a well-defined silicon nanocone (SNC) on silicon wafer sample has been fabricated as a model electrode in lithium ion batteries to investigate the growth of surface species on the SNC electrode during cycling using ex situ scanning electronic microscopy. It is observed that an extra 5 μm thick layer covers the top of the SNCs after 25 cycles at 0.1 C. This top layer has been proven to be a solid electrolyte interphase (SEI) layer by designing a solid lithium battery. It is noticed that the SEI layer is much thinner at a high rate of 1 C. The cyclic performance of the SNCs at 1 C looks much better than that of the same electrode at 0.1 C in the half cell. Our findings clearly demonstrate that the formation of the thick SEI on the naked nanostructured Si anode during low rate cycling is a serious problem for practical applications. An in depth understanding of this problem may provide valuable guidance in designing Si-based anode materials.

Multiple attractors and boundary crises in a tri-trophic food chain.

PubMed

Boer, M P; Kooi, B W; Kooijman, S A

2001-02-01

The asymptotic behaviour of a model of a tri-trophic food chain in the chemostat is analysed in detail. The Monod growth model is used for all trophic levels, yielding a non-linear dynamical system of four ordinary differential equations. Mass conservation makes it possible to reduce the dimension by 1 for the study of the asymptotic dynamic behaviour. The intersections of the orbits with a Poincaré plane, after the transient has died out, yield a two-dimensional Poincaré next-return map. When chaotic behaviour occurs, all image points of this next-return map appear to lie close to a single curve in the intersection plane. This motivated the study of a one-dimensional bi-modal, non-invertible map of which the graph resembles this curve. We will show that the bifurcation structure of the food chain model can be understood in terms of the local and global bifurcations of this one-dimensional map. Homoclinic and heteroclinic connecting orbits and their global bifurcations are discussed also by relating them to their counterparts for a two-dimensional map which is invertible like the next-return map. In the global bifurcations two homoclinic or two heteroclinic orbits collide and disappear. In the food chain model two attractors coexist; a stable limit cycle where the top-predator is absent and an interior attractor. In addition there is a saddle cycle. The stable manifold of this limit cycle forms the basin boundary of the interior attractor. We will show that this boundary has a complicated structure when there are heteroclinic orbits from a saddle equilibrium to this saddle limit cycle. A homoclinic bifurcation to a saddle limit cycle will be associated with a boundary crisis where the chaotic attractor disappears suddenly when a bifurcation parameter is varied. Thus, similar to a tangent local bifurcation for equilibria or limit cycles, this homoclinic global bifurcation marks a region in the parameter space where the top-predator goes extinct. The 'Paradox of Enrichment' says that increasing the concentration of nutrient input can cause destabilization of the otherwise stable interior equilibrium of a bi-trophic food chain. For a tri-trophic food chain enrichment of the environment can even lead to extinction of the highest trophic level.

Periodic expression of nuclear and mitochondrial DNA replication genes during the trypanosomatid cell cycle.

PubMed

Pasion, S G; Brown, G W; Brown, L M; Ray, D S

1994-12-01

In trypanosomatids, DNA replication in the nucleus and in the single mitochondrion (or kinetoplast) initiates nearly simultaneously, suggesting that the DNA synthesis (S) phases of the nucleus and the mitochondrion are coordinately regulated. To investigate the basis for the temporal link between nuclear and mitochondrial DNA synthesis phases the expression of the genes encoding DNA ligase I, the 51 and 28 kDa subunits of replication protein A, dihydrofolate reductase and the mitochondrial type II topoisomerase were analyzed during the cell cycle progression of synchronous cultures of Crithidia fasciculata. These DNA replication genes were all expressed periodically, with peak mRNA levels occurring just prior to or at the peak of DNA synthesis in the synchronized cultures. A plasmid clone (pdN-1) in which TOP2, the gene encoding the mitochondrial topoisomerase, was disrupted by the insertion of a NEO drug-resistance cassette was found to express both a truncated TOP2 mRNA and a truncated topoisomerase polypeptide. The truncated mRNA was also expressed periodically coordinate with the expression of the endogenous TOP2 mRNA indicating that cis elements necessary for periodic expression are contained within cloned sequences. The expression of both TOP2 and nuclear DNA replication genes at the G1/S boundary suggests that regulated expression of these genes may play a role in coordinating nuclear and mitochondrial S phases in trypanosomatids.

Cell module and fuel conditioner development

NASA Technical Reports Server (NTRS)

Feret, J. M.

1982-01-01

The efforts performed to develop a phosphoric acid fuel cell (PAFC) stack design having a 10 kW power rating for operation at higher than atmospheric pressure based on the existing Mark II design configuration are described. The work involves: (1) Performance of pertinent functional analysis, trade studies and thermodynamic cycle analysis for requirements definition and system operating parameter selection purposes, (2) characterization of fuel cell materials and components, and performance testing and evaluation of the repeating electrode components, (3) establishment of the state-of-the-art manufacturing technology for all fuel cell components at Westinghouse and the fabrication of short stacks of various sites, and (4) development of a 10 kW PAFC stack design for higher pressure operation utilizing the top down systems engineering approach.

Effects of predation efficiencies on the dynamics of a tritrophic food chain.

PubMed

Cassinari, Maria Paola; Groppi, Maria; Tebaldi, Claudio

2007-07-01

In this paper the dynamics of a tritrophic food chain (resource, consumer, top predator) is investigated, with particular attention not only to equilibrium states but also to cyclic behaviours that the system may exhibit. The analysis is performed in terms of two bifurcation parameters, denoted by p and q, which measure the efficiencies of the interaction processes. The persistence of the system is discussed, characterizing in the (p; q) plane the regions of existence and stability of biologically significant steady states and those of existence of limit cycles. The bifurcations occurring are discussed, and their implications with reference to biological control problems are considered. Examples of the rich dynamics exhibited by the model, including a chaotic regime, are described.

Internal Solitary Waves Induced by Flow Over a Ridge: With Applications to the Northern South China Sea

DTIC Science & Technology

2009-02-24

0.0061 rad s ’ (3.5 cycles h ’) in dark blue to 0.0079 rad s (4.5 cycles h ’) in dark red. Two ridges are present in the Luzon Strait: the east...02019 Figure 8. Monthly mean buoyancy frequency at 400 m in the Luzon Strait. The color varies progressively from dark blue at 3.5 cycles h...8217 (0.0061 rads ’) to dark red at 4.5 cycles h ’ (0.0079 rads ’). The islands at top and bottom of Figure 8 are Taiwan and Luzon, respectively. between April

In situ monitoring using Lab on Chip devices, with particular reference to dissolved silica.

NASA Astrophysics Data System (ADS)

Turner, G. S. C.; Loucaides, S.; Slavik, G. J.; Owsianka, D. R.; Beaton, A.; Nightingale, A.; Mowlem, M. C.

2016-02-01

In situ sensors are attractive alternatives to discrete sampling of natural waters, offering the potential for sustained long term monitoring and eliminating the need for sample handling. This can reduce sample contamination and degradation. In addition, sensors can be clustered into multi-parameter observatories and networked to provide both spatial and time series coverage. High resolution, low cost, and long term monitoring are the biggest advantages of these technologies to oceanographers. Microfluidic technology miniaturises bench-top assay systems into portable devices, known as a `lab on a chip' (LOC). The principle advantages of this technology are low power consumption, simplicity, speed, and stability without compromising on quality (accuracy, precision, selectivity, sensitivity). We have successfully demonstrated in situ sensors based on this technology for the measurement of pH, nitrate and nitrite. Dissolved silica (dSi) is an important macro-nutrient supporting a major fraction of oceanic primary production carried out by diatoms. The biogeochemical Si cycle is undergoing significant modifications due to human activities, which affects availability of dSi, and consequently primary production. Monitoring dSi concentrations is therefore critical in increasing our understanding of the biogeochemical Si cycle to predict and manage anthropogenic perturbations. The standard bench top air segmented flow technique utilising the reduction of silicomolybdic acid with spectrophotometric detection has been miniaturised into a LOC system; the target limit of detection is 1 nM, with ± 5% accuracy and 3% precision. Results from the assay optimisation are presented along with reagent shelf life to demonstrate the robustness of the chemistry. Laboratory trials of the sensor using ideal solutions and environmental samples in environmentally relevant conditions (temperature, pressure) are discussed, along with an overview of our current LOC analytical capabilities.

TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cells.

PubMed

Jeon, Yoon; Ko, Eun; Lee, Kyung Yong; Ko, Min Ji; Park, Seo Young; Kang, Jeeheon; Jeon, Chang Hwan; Lee, Ho; Hwang, Deog Su

2011-02-18

TopBP1 plays important roles in chromosome replication, DNA damage response, and other cellular regulatory functions in vertebrates. Although the roles of TopBP1 have been studied mostly in cancer cell lines, its physiological function remains unclear in mice and untransformed cells. We generated conditional knock-out mice in which exons 5 and 6 of the TopBP1 gene are flanked by loxP sequences. Although TopBP1-deficient embryos developed to the blastocyst stage, no homozygous mutant embryos were recovered at E8.5 or beyond, and completely resorbed embryos were frequent at E7.5, indicating that mutant embryos tend to die at the peri-implantation stage. This finding indicated that TopBP1 is essential for cell proliferation during early embryogenesis. Ablation of TopBP1 in TopBP1(flox/flox) mouse embryonic fibroblasts and 3T3 cells using Cre recombinase-expressing retrovirus arrests cell cycle progression at the G(1), S, and G(2)/M phases. The TopBP1-ablated mouse cells exhibit phosphorylation of H2AX and Chk2, indicating that the cells contain DNA breaks. The TopBP1-ablated mouse cells enter cellular senescence. Although RNA interference-mediated knockdown of TopBP1 induced cellular senescence in human primary cells, it induced apoptosis in cancer cells. Therefore, TopBP1 deficiency in untransformed mouse and human primary cells induces cellular senescence rather than apoptosis. These results indicate that TopBP1 is essential for cell proliferation and maintenance of chromosomal integrity.

TeleOperator/telePresence System (TOPS) Concept Verification Model (CVM) development

NASA Technical Reports Server (NTRS)

Shimamoto, Mike S.

1993-01-01

The development of an anthropomorphic, undersea manipulator system, the TeleOperator/telePresence System (TOPS) Concept Verification Model (CVM) is described. The TOPS system's design philosophy, which results from NRaD's experience in undersea vehicles and manipulator systems development and operations, is presented. The TOPS design approach, task teams, manipulator, and vision system development and results, conclusions, and recommendations are presented.

Neocortical dynamics due to axon propagation delays in cortico-cortical fibers: EEG traveling and standing waves with implications for top-down influences on local networks and white matter disease

PubMed Central

Nunez, Paul L.; Srinivasan, Ramesh

2013-01-01

The brain is treated as a nested hierarchical complex system with substantial interactions across spatial scales. Local networks are pictured as embedded within global fields of synaptic action and action potentials. Global fields may act top-down on multiple networks, acting to bind remote networks. Because of scale-dependent properties, experimental electrophysiology requires both local and global models that match observational scales. Multiple local alpha rhythms are embedded in a global alpha rhythm. Global models are outlined in which cm-scale dynamic behaviors result largely from propagation delays in cortico-cortical axons and cortical background excitation level, controlled by neuromodulators on long time scales. The idealized global models ignore the bottom-up influences of local networks on global fields so as to employ relatively simple mathematics. The resulting models are transparently related to several EEG and steady state visually evoked potentials correlated with cognitive states, including estimates of neocortical coherence structure, traveling waves, and standing waves. The global models suggest that global oscillatory behavior of self-sustained (limit-cycle) modes lower than about 20 Hz may easily occur in neocortical/white matter systems provided: Background cortical excitability is sufficiently high; the strength of long cortico-cortical axon systems is sufficiently high; and the bottom-up influence of local networks on the global dynamic field is sufficiently weak. The global models provide "entry points" to more detailed studies of global top-down influences, including binding of weakly connected networks, modulation of gamma oscillations by theta or alpha rhythms, and the effects of white matter deficits. PMID:24505628

Top-level dynamics and the regulated gene response of feed-forward loop transcriptional motifs.

PubMed

Mayo, Michael; Abdelzaher, Ahmed; Perkins, Edward J; Ghosh, Preetam

2014-09-01

Feed-forward loops are hierarchical three-node transcriptional subnetworks, wherein a top-level protein regulates the activity of a target gene via two paths: a direct-regulatory path, and an indirect route, whereby the top-level proteins act implicitly through an intermediate transcription factor. Using a transcriptional network of the model bacterium Escherichia coli, we confirmed that nearly all types of feed-forward loop were significantly overrepresented in the bacterial network. We then used mathematical modeling to study their dynamics by manipulating the rise times of the top-level protein concentration, termed the induction time, through alteration of the protein destruction rates. Rise times of the regulated proteins exhibited two qualitatively different regimes, depending on whether top-level inductions were "fast" or "slow." In the fast regime, rise times were nearly independent of rapid top-level inductions, indicative of biological robustness, and occurred when RNA production rate-limits the protein yield. Alternatively, the protein rise times were dependent upon slower top-level inductions, greater than approximately one bacterial cell cycle. An equation is given for this crossover, which depends upon three parameters of the direct-regulatory path: transcriptional cooperation at the DNA-binding site, a protein-DNA dissociation constant, and the relative magnitude of the top-level protien concentration.

Hurricane Wilma

Atmospheric Science Data Center

2014-05-15

... Information on cloud top heights at different stages in the life cycle of the rapidly intensifying Hurricane Wilma may prove useful for ... NASA's Jet Propulsion Laboratory, Pasadena, CA, for NASA's Science Mission Directorate, Washington, D.C. The Terra spacecraft is managed ...

Incorporating ecogeomorphic feedbacks to better understand resiliency in streams: A review and directions forward

NASA Astrophysics Data System (ADS)

Atkinson, Carla L.; Allen, Daniel C.; Davis, Lisa; Nickerson, Zachary L.

2018-03-01

Decades of interdisciplinary research show river form and function depends on interactions between the living and nonliving world, but a dominant paradigm underlying ecogeomorphic work consists of a top-down, unidirectional approach with abiotic forces driving biotic systems. Stream form and location within the stream network does dictate the habitat and resources available for organisms and overall community structure. Yet this traditional hierarchal framework on its own is inadequate in communicating information regarding the influence of biological systems on fluvial geomorphology that lead to changes in channel morphology, sediment cycling, and system-scale functions (e.g., sediment yield, biogeochemical nutrient cycling). Substantial evidence that organisms influence fluvial geomorphology exists, specifically the ability of aquatic vegetation and lotic animals to modify flow velocities and sediment deposition and transport - thus challenging the traditional hierarchal framework. Researchers recognize the need for ecogeomorphic frameworks that conceptualize feedbacks between organisms, sediment transport, and geomorphic structure. Furthermore, vital ecosystem processes, such as biogeochemical nutrient cycling represent the conversations that are occurring between geomorphological and biological systems. Here we review and synthesize selected case studies highlighting the role organisms play in moderating geomorphic processes and likely interact with these processes to have an impact on an essential ecosystem process, biogeochemical nutrient recycling. We explore whether biophysical interactions can provide information essential to improving predictions of system-scale river functions, specifically sediment transport and biogeochemical cycling, and discuss tools used to study these interactions. We suggest that current conceptual frameworks should acknowledge that hydrologic, geomorphologic, and ecologic processes operate on different temporal scales, generating bidirectional feedback loops over space and time. Hydro- and geomorphologic processes, operating episodically during bankfull conditions, influence ecological processes (e.g., biogeochemical cycling) occurring over longer time periods during base-flow conditions. This ecological activity generates the antecedent conditions that influence the hydro- and geomorphologic processes occurring during the next high flow event, creating a bidirectional feedback. This feedback should enhance the resiliency of fluvial landforms and ecosystem processes, allowing physical and biological processes to pull and push against each other over time.

Interactive chemistry management system (ICMS); Field demonstration results at United Illuminating

DOE Office of Scientific and Technical Information (OSTI.GOV)

Noto, F.A.; Farrell, D.M.; Lombard, E.V.

1988-01-01

The authors report on a field demonstration of the interactive chemistry management system (ICMS) performed in the late summer of 1987 at the New Haven Harbor Station of United Illuminating Co. This demonstration was the first installation of the ICMS at an actual plant site. The ICMS is a computer-based system designed to monitor, diagnose, and provide optional automatic control of water and steam chemistry throughout the steam generator cycle. It is one of the diagnostic modules that comprises CE-TOPS (combustion engineering total on-line performance system), which continuously monitors operating conditions and suggests priority actions to increase operation efficiency, extendmore » the performance life of boiler components and reduce maintenance costs. By reducing the number of forced outages through early identification of potentially detrimental conditions, diagnosis of possible causes, and execution of corrective actions, improvements in unit availability and reliability will result.« less

Biomechanical Effects of a Dynamic Topping off Instrumentation in a Long Rigid Pedicle Screw Construct.

PubMed

Reichl, Michael; Kueny, Rebecca A; Danyali, Reza; Obid, Peter; Übeyli, Hüseyin; Püschel, Klaus; Morlock, Michael M; Huber, Gerd; Niemeyer, Thomas; Richter, Alexander

2017-05-01

Biomechanical ex vivo study. To determine if topping off instrumentation can reduce the hypermobility in the adjacent segments when compared with the classic rigid spinal instrumentation. Long rigid instrumentation might increase the mechanical load in the adjacent segments, the resulting hypermobility, and the risk for adjacent segment disease. Topping off instrumentation intends to reduce the hypermobility at the adjacent level by more evenly distributing segmental motion and, thereby, potentially mitigating adjacent level disease. Eight human spines (Th12-L5) were divided into 2 groups. In the rigid group, a 3-segment metal rod instrumentation (L2-L5) was performed. The hybrid group included a 2-segment metal rod instrumentation (L3-L5) with a dynamic topping off instrumentation (L2-L3). Each specimen was tested consecutively in 3 different configurations: native (N=8), 2-segment rod instrumentation (L3-L5, N=8), 3-segment instrumentation (rigid: N=4, hybrid: N=4). For each configuration the range of motion (ROM) of the whole spine and each level was measured by a motion capture system during 5 cycles of extension-flexion (angle controlled to ±5 degrees, 0.1 Hz frequency, no preload). In comparison with the intact spine, both the rigid 3-segment instrumentation and the hybrid instrumentation significantly reduced the ROM in the instrumented segments (L2-L5) while increasing the movement in the adjacent segment L1-L2 (P=0.002, η=0.82) and in Th12-L1 (P<0.001, η=0.90). There were no ROM differences between the rigid and hybrid instrumentation in all segments. Introducing the dynamic topping off did not impart any significant difference in the segmental motion when compared with the rigid instrumentation. Therefore, the current biomechanical study could not show a benefit of using this specific topping off instrumentation to solve the problem of adjacent segment disease.

Characteristics of Precipitation, Cloud, and Latent Heating Associated with the Madden-Julian Oscillation

NASA Technical Reports Server (NTRS)

Lau, K-M.; Wu, H-T.

2010-01-01

This study investigates the evolution of cloud and rainfall structures associated with Madden Julian oscillation (MJO) using Tropical Rainfall Measuring Mission (TRMM) data. Two complementary indices are used to define MJO phases. Joint probability distribution functions (PDFs) of cloud-top temperature and radar echo-top height are constructed for each of the eight MJO phases. The genesis stage of MJO convection over the western Pacific (phases 1 and 2) features a bottom-heavy PDF, characterized by abundant warm rain, low clouds, suppressed deep convection, and higher sea surface temperature (SST). As MJO convection develops (phases 3 and 4), a transition from the bottom-heavy to top-heavy PDF occurs. The latter is associated with the development of mixed-phase rain and middle-to-high clouds, coupled with rapid SST cooling. At the MJO convection peak (phase 5), a top-heavy PDF contributed by deep convection with mixed-phase and ice-phase rain and high echo-top heights (greater than 5 km) dominates. The decaying stage (phases 6 and 7) is characterized by suppressed SST, reduced total rain, increased contribution from stratiform rain, and increased nonraining high clouds. Phase 7, in particular, signals the beginning of a return to higher SST and increased warm rain. Phase 8 completes the MJO cycle, returning to a bottom-heavy PDF and SST conditions similar to phase 1. The structural changes in rain and clouds at different phases of MJO are consistent with corresponding changes in derived latent heating profiles, suggesting the importance of a diverse mix of warm, mixed-phase, and ice-phase rain associated with low-level, congestus, and high clouds in constituting the life cycle and the time scales of MJO.

Upper Ocean Measurements from Profiling Floats in the Arabian Sea During NASCar

DTIC Science & Technology

2015-09-30

top-level goals] OBJECTIVES The work proposed here is designed to examine the seasonal evolution of the upper ocean in the northern Arabian...Sea over several seasonal cycles, with the specific objectives of (1) Documenting the spatial variations in the seasonal cycle of the upper ocean...circulation of the Arabian Sea and the seasonal and spatial evolution of the surface mixed layer, and would be used in conjunction with HYCOM model

Microphysical effects determine macrophysical response for aerosol impacts on deep convective clouds

NASA Astrophysics Data System (ADS)

Fan, Jiwen; Leung, L. Ruby; Rosenfeld, Daniel; Chen, Qian; Li, Zhanqing; Zhang, Jinqiang; Yan, Hongru

2013-11-01

Deep convective clouds (DCCs) play a crucial role in the general circulation, energy, and hydrological cycle of our climate system. Aerosol particles can influence DCCs by altering cloud properties, precipitation regimes, and radiation balance. Previous studies reported both invigoration and suppression of DCCs by aerosols, but few were concerned with the whole life cycle of DCC. By conducting multiple monthlong cloud-resolving simulations with spectral-bin cloud microphysics that capture the observed macrophysical and microphysical properties of summer convective clouds and precipitation in the tropics and midlatitudes, this study provides a comprehensive view of how aerosols affect cloud cover, cloud top height, and radiative forcing. We found that although the widely accepted theory of DCC invigoration due to aerosol's thermodynamic effect (additional latent heat release from freezing of greater amount of cloud water) may work during the growing stage, it is microphysical effect influenced by aerosols that drives the dramatic increase in cloud cover, cloud top height, and cloud thickness at the mature and dissipation stages by inducing larger amounts of smaller but longer-lasting ice particles in the stratiform/anvils of DCCs, even when thermodynamic invigoration of convection is absent. The thermodynamic invigoration effect contributes up to ∼27% of total increase in cloud cover. The overall aerosol indirect effect is an atmospheric radiative warming (3-5 Wṡm-2) and a surface cooling (-5 to -8 Wṡm-2). The modeling findings are confirmed by the analyses of ample measurements made at three sites of distinctly different environments.

Microphysical effects determine macrophysical response for aerosol impacts on deep convective clouds.

PubMed

Fan, Jiwen; Leung, L Ruby; Rosenfeld, Daniel; Chen, Qian; Li, Zhanqing; Zhang, Jinqiang; Yan, Hongru

2013-11-26

Deep convective clouds (DCCs) play a crucial role in the general circulation, energy, and hydrological cycle of our climate system. Aerosol particles can influence DCCs by altering cloud properties, precipitation regimes, and radiation balance. Previous studies reported both invigoration and suppression of DCCs by aerosols, but few were concerned with the whole life cycle of DCC. By conducting multiple monthlong cloud-resolving simulations with spectral-bin cloud microphysics that capture the observed macrophysical and microphysical properties of summer convective clouds and precipitation in the tropics and midlatitudes, this study provides a comprehensive view of how aerosols affect cloud cover, cloud top height, and radiative forcing. We found that although the widely accepted theory of DCC invigoration due to aerosol's thermodynamic effect (additional latent heat release from freezing of greater amount of cloud water) may work during the growing stage, it is microphysical effect influenced by aerosols that drives the dramatic increase in cloud cover, cloud top height, and cloud thickness at the mature and dissipation stages by inducing larger amounts of smaller but longer-lasting ice particles in the stratiform/anvils of DCCs, even when thermodynamic invigoration of convection is absent. The thermodynamic invigoration effect contributes up to ~27% of total increase in cloud cover. The overall aerosol indirect effect is an atmospheric radiative warming (3-5 W m(-2)) and a surface cooling (-5 to -8 W m(-2)). The modeling findings are confirmed by the analyses of ample measurements made at three sites of distinctly different environments.

Ceramic thermal barrier coating for rapid thermal cycling applications

DOEpatents

Scharman, Alan J.; Yonushonis, Thomas M.

1994-01-01

A thermal barrier coating for metal articles subjected to rapid thermal cycling includes a metallic bond coat deposited on the metal article, at least one MCrAlY/ceramic layer deposited on the bond coat, and a ceramic top layer deposited on the MCrAlY/ceramic layer. The M in the MCrAlY material is Fe, Ni, Co, or a mixture of Ni and Co. The ceramic in the MCrAlY/ceramic layer is mullite or Al.sub.2 O.sub.3. The ceramic top layer includes a ceramic with a coefficient of thermal expansion less than about 5.4.times.10.sup.-6 .degree.C.sup.-1 and a thermal conductivity between about 1 J sec.sup.-1 m.sup.-1 .degree.C.sup.-1 and about 1.7 J sec.sup.-1 m.sup.-1 .degree.C.sup.-1.

Optical spectrum measurement of a cell-adhered microcavity for the cell-cycle analysis applications

NASA Astrophysics Data System (ADS)

Saito, Ryusuke; Terakawa, Mitsuhiro; Tanabe, Takasumi

2015-03-01

We build a setup and demonstrate successful measurement of the transmittance spectrum of a whispering gallery mode silica optical microcavity in which NIH 3T3 cells adhered on the top surface to achieve real-time and label-free measurement of the cell cycle. Label-free measurement is expected to prevent the cells to exhibit secondary effect. We build a system that enables the control of the gap distance between the microcavity and the tapered fiber, both of which are placed in the cell culture medium. The optimization of the tapered fiber diameter is the key to measure the spectrum of a microcavity in liquid. A swept wavelength laser light at a wavelength of 766 to 780 nm is used for the measurement. The cavity exhibit a Q of 1 . 0 ×106 in air, where the value is 1 . 0 ×105 in the medium and drops to 3 . 1 ×104 after the cell-adhesion. Still the Q of the microcavity is sufficiently high to detect the change at the cavity surface. Indeed we observe slight spectrum shift toward a longer wavelength, which we believe is due to the adherence of NIH 3T3 cells on the silica microcavity.The successful measurement of the transmittance spectrum of a microcavity in cell culture medium is the first step to realize the analysis of the cell-cycle based on microcavity system.

Carbon and Nitrogen Isotopes from Top Predator Amino Acids Reveal Rapidly Shifting Ocean Biochemistry in the Outer California Current

PubMed Central

Ruiz-Cooley, Rocio I.; Koch, Paul L.; Fiedler, Paul C.; McCarthy, Matthew D.

2014-01-01

Climatic variation alters biochemical and ecological processes, but it is difficult both to quantify the magnitude of such changes, and to differentiate long-term shifts from inter-annual variability. Here, we simultaneously quantify decade-scale isotopic variability at the lowest and highest trophic positions in the offshore California Current System (CCS) by measuring δ15N and δ13C values of amino acids in a top predator, the sperm whale (Physeter macrocephalus). Using a time series of skin tissue samples as a biological archive, isotopic records from individual amino acids (AAs) can reveal the proximate factors driving a temporal decline we observed in bulk isotope values (a decline of ≥1 ‰) by decoupling changes in primary producer isotope values from those linked to the trophic position of this toothed whale. A continuous decline in baseline (i.e., primary producer) δ15N and δ13C values was observed from 1993 to 2005 (a decrease of ∼4‰ for δ15N source-AAs and 3‰ for δ13C essential-AAs), while the trophic position of whales was variable over time and it did not exhibit directional trends. The baseline δ15N and δ13C shifts suggest rapid ongoing changes in the carbon and nitrogen biogeochemical cycling in the offshore CCS, potentially occurring at faster rates than long-term shifts observed elsewhere in the Pacific. While the mechanisms forcing these biogeochemical shifts remain to be determined, our data suggest possible links to natural climate variability, and also corresponding shifts in surface nutrient availability. Our study demonstrates that isotopic analysis of individual amino acids from a top marine mammal predator can be a powerful new approach to reconstructing temporal variation in both biochemical cycling and trophic structure. PMID:25329915

Carbon and nitrogen isotopes from top predator amino acids reveal rapidly shifting ocean biochemistry in the outer California Current.

PubMed

Ruiz-Cooley, Rocio I; Koch, Paul L; Fiedler, Paul C; McCarthy, Matthew D

2014-01-01

Climatic variation alters biochemical and ecological processes, but it is difficult both to quantify the magnitude of such changes, and to differentiate long-term shifts from inter-annual variability. Here, we simultaneously quantify decade-scale isotopic variability at the lowest and highest trophic positions in the offshore California Current System (CCS) by measuring δ15N and δ13C values of amino acids in a top predator, the sperm whale (Physeter macrocephalus). Using a time series of skin tissue samples as a biological archive, isotopic records from individual amino acids (AAs) can reveal the proximate factors driving a temporal decline we observed in bulk isotope values (a decline of ≥1 ‰) by decoupling changes in primary producer isotope values from those linked to the trophic position of this toothed whale. A continuous decline in baseline (i.e., primary producer) δ15N and δ13C values was observed from 1993 to 2005 (a decrease of ∼4‰ for δ15N source-AAs and 3‰ for δ13C essential-AAs), while the trophic position of whales was variable over time and it did not exhibit directional trends. The baseline δ15N and δ13C shifts suggest rapid ongoing changes in the carbon and nitrogen biogeochemical cycling in the offshore CCS, potentially occurring at faster rates than long-term shifts observed elsewhere in the Pacific. While the mechanisms forcing these biogeochemical shifts remain to be determined, our data suggest possible links to natural climate variability, and also corresponding shifts in surface nutrient availability. Our study demonstrates that isotopic analysis of individual amino acids from a top marine mammal predator can be a powerful new approach to reconstructing temporal variation in both biochemical cycling and trophic structure.

Stratocumulus Cloud Top Radiative Cooling and Cloud Base Updraft Speeds

NASA Astrophysics Data System (ADS)

Kazil, J.; Feingold, G.; Balsells, J.; Klinger, C.

2017-12-01

Cloud top radiative cooling is a primary driver of turbulence in the stratocumulus-topped marine boundary. A functional relationship between cloud top cooling and cloud base updraft speeds may therefore exist. A correlation of cloud top radiative cooling and cloud base updraft speeds has been recently identified empirically, providing a basis for satellite retrieval of cloud base updraft speeds. Such retrievals may enable analysis of aerosol-cloud interactions using satellite observations: Updraft speeds at cloud base co-determine supersaturation and therefore the activation of cloud condensation nuclei, which in turn co-determine cloud properties and precipitation formation. We use large eddy simulation and an off-line radiative transfer model to explore the relationship between cloud-top radiative cooling and cloud base updraft speeds in a marine stratocumulus cloud over the course of the diurnal cycle. We find that during daytime, at low cloud water path (CWP < 50 g m-2), cloud base updraft speeds and cloud top cooling are well-correlated, in agreement with the reported empirical relationship. During the night, in the absence of short-wave heating, CWP builds up (CWP > 50 g m-2) and long-wave emissions from cloud top saturate, while cloud base heating increases. In combination, cloud top cooling and cloud base updrafts become weakly anti-correlated. A functional relationship between cloud top cooling and cloud base updraft speed can hence be expected for stratocumulus clouds with a sufficiently low CWP and sub-saturated long-wave emissions, in particular during daytime. At higher CWPs, in particular at night, the relationship breaks down due to saturation of long-wave emissions from cloud top.

The Top Chron C27n Event in the Western Atlantic: Evidence for a transient perturbation of the carbon cycle in the Late Danian?

NASA Astrophysics Data System (ADS)

Schulte, Peter; Bornemann, André; Speijer, Robert P.

2010-05-01

The Paleocene to early Eocene is punctuated by several transient, ˜20-200 ky lasting hyperthermal events of which the Paleocene-Eocene Thermal Maximum (PETM) was the most prominent one. Abrupt shallowing of the lysocline/CCD, negative carbon isotope excursions, and benthic faunal turnover all imply a major perturbation of the ocean system during these events. Our recent research at the Southern Tethyan shelf suggests the presence of an additional hyperthermal event associated with sea-level fluctuations, the Latest Danian Event (LDE; Speijer, 2003; Bornemann et al., 2009). At Zumaia, Northern Spain, a negative ~0.5 per mil carbon isotope excursion is present in the uppermost Danian that may correlate to the LDE (Arenillas et al. 2008). Moreover, cyclostratigraphic studies have shown that several deep-sea sites are characterized by a prominent peak in both Fe and MS data at cycle Pc100-38 in the uppermost Danian: this applies to all Walvis Ridge (Atlantic) and Shatsky Rise (Pacific) sites as well as Site 1001 in the Caribbean Sea (Top Chron C27n Event; Westerhold et al., 2007). These results suggest that the LDE in the Tethys and the Top Chron C27n Event in the Atlantic may be correlative. We have conducted mineralogical, geochemical, and micropaleontological investigations to characterize this event in the Western Atlantic. Our first results from ODP Leg 165 Site 1001 show that the Top Chron 27n Event shown by Westerhold el al. (2008) corresponds to a ~12 cm thick clay layer. Mineralogical analyses reveal a sharp ~50% drop of the carbonate content in the clay layer and a disproportionally high increase of the phyllosilicate content in the insoluble residue compared to the quartz and illite content. Bulk rock isotope analyses show an abrupt negative ~0.6 per mil carbon isotope excursion at the onset of the clay layer, followed by a 1-m thick interval where carbon isotopes shows a tailing back to pre-event values. The magnitude and pattern of the carbon isotope excursion is very similar to the results for the LDE in the Tethys and at Zumaia. In conclusion, our results demonstrate a supra-regional transient perturbation of the carbon cycle during the LDE in the Tethyan realm, the Atlantic, and possibly the Pacific Ocean. Arenillas, I. et al., 2008, Terra Nova v. 20, p. 38-44. Bornemann, A. et al., 2009, Journal of the Geological Society, London v. 166, p. 1135-1142. Speijer, R.P., 2003, GSA Special Paper v. 369, p. 275-290. Westerhold, T. et al., 2007, Palaeogeography, Palaeoclimatology, Palaeoecology v. 257, p. 377-403.

George Hoyt Whipple and the Impact of Liver on Anemia

Science.gov Websites

Nobel Prize for his discovery that liver fed to anemic dogs reverses the effects of the anemia. This Effects of Ionizing Radiation Cycle, DOE Technical Report, 1952 Top Additional Web Pages: George H

Premenstrual Syndrome (PMS)

MedlinePlus

... PMS? top No one knows for sure what causes PMS, but it seems to be linked to the changes in hormone levels that happen during your menstrual cycle . PMS is not caused by anxiety or depression . They can make your PMS symptoms worse, though, ...

Top-mounted inlet system feasibility for transonic-supersonic fighter aircraft. [V/STOL aircraft

NASA Technical Reports Server (NTRS)

Williams, T. L.; Hunt, B. L.; Smeltzer, D. B.; Nelms, W. P.

1981-01-01

The more salient findings are presented of recent top inlet performance evaluations aimed at assessing the feasibility of top-mounted inlet systems for transonic-supersonic fighter aircraft applications. Top inlet flow field and engine-inlet performance test data show the influence of key aircraft configuration variables-inlet longitudinal position, wing leading-edge extension planform area, canopy-dorsal integration, and variable incidence canards-on top inlet performance over the Mach range of 0.6 to 2.0. Top inlet performance data are compared with those or more conventional inlet/airframe integrations in an effort to assess the viability of top-mounted inlet systems relative to conventional inlet installations.

Clomiphene citrate is associated with favorable cycle characteristics but impaired outcomes of obese women with polycystic ovarian syndrome undergoing ovarian stimulation for in vitro fertilization

PubMed Central

Jiang, Shutian; Kuang, Yanping

2017-01-01

Abstract The aim of this study was to explore the effect of clomiphene citrate (CC) on the cycle characteristics and outcomes of obese women with polycystic ovarian syndrome (PCOS) undergoing ovarian stimulation for in vitro fertilization (IVF). This is a retrospective cohort study, and it was conducted at the tertiary-care academic medical center. This study included 174 obese PCOS patients undergoing IVF. In the study group (n = 90), CC and human menopausal gonadotropin (HMG) were administered simultaneously beginning on cycle day 3, while in control group (n = 84) HMG was used only. Both of the 2 groups used medroxyprogesterone acetate (MPA) for preventing premature luteinizing hormone (LH) surges. Ovulation was cotriggered by a GnRH agonist and hCG when dominant follicles matured. The primary outcome measure was the number of oocytes retrieved. Secondary outcomes included the number of top-quality embryos, maturation rate, fertilization rate, cleavage rate, incidence of premature LH surge, and OHSS. The study group received obviously lower total HMG dose [1650 (975–4800) vs 2025 (1350–3300) IU, P = 2.038E–4] but similar HMG duration. While the antral follicle count (AFC) is higher in study group, the number of oocytes retrieved and top-quality embryos are remarkably less [5 (0–30) vs 13 (0–42), P = 6.333E–5; 2 (0–14) vs 3.5 (0–15), P = .003; respectively]. The mature oocyte rate is higher in study group (P = .036). No significant differences were detected in fertilization rate and cleavage rate between 2 groups. CC has a positive influence on cycle characteristics, but might be correlated with the impaired IVF outcomes (less oocytes retrieved and top quality embryos, lower oocyte retrieval rate) in obese PCOS patients undergoing IVF, when HMG and MPA are used simultaneously. PMID:28796038

A miniature bidirectional telemetry system for in vivo gastric slow wave recordings.

PubMed

Farajidavar, Aydin; O'Grady, Gregory; Rao, Smitha M N; Cheng, Leo K; Abell, Thomas; Chiao, J-C

2012-06-01

Stomach contractions are initiated and coordinated by an underlying electrical activity (slow waves), and electrical dysrhythmias accompany motility diseases. Electrical recordings taken directly from the stomach provide the most valuable data, but face technical constraints. Serosal or mucosal electrodes have cables that traverse the abdominal wall, or a natural orifice, causing discomfort and possible infection, and restricting mobility. These problems motivated the development of a wireless system. The bidirectional telemetric system constitutes a front-end transponder, a back-end receiver and a graphical userinter face. The front-end module conditions the analogue signals, then digitizes and loads the data into a radio for transmission. Data receipt at the backend is acknowledged via a transceiver function. The system was validated in a bench-top study, then validated in vivo using serosal electrodes connected simultaneously to a commercial wired system. The front-end module was 35 × 35 × 27 mm3 and weighed 20 g. Bench-top tests demonstrated reliable communication within a distance range of 30 m, power consumption of 13.5 mW, and 124 h operation when utilizing a 560 mAh, 3 V battery. In vivo,slow wave frequencies were recorded identically with the wireless and wired reference systems (2.4 cycles min−1), automated activation time detection was modestly better for the wireless system (5% versus 14% FP rate), and signal amplitudes were modestly higher via the wireless system (462 versus 3 86μV; p<0.001). This telemetric system for slow wave acquisition is reliable,power efficient, readily portable and potentially implantable. The device will enable chronic monitoring and evaluation of slow wave patterns in animals and patients.0967-3334/

A miniature bidirectional telemetry system for in-vivo gastric slow wave recordings

PubMed Central

Farajidavar, Aydin; O’Grady, Gregory; Rao, Smitha M.N.; Cheng, Leo K; Abell, Thomas; Chiao, J.-C.

2012-01-01

Stomach contractions are initiated and coordinated by an underlying electrical activity (slow waves), and electrical dysrhythmias accompany motility diseases. Electrical recordings taken directly from the stomach provide the most valuable data, but face technical constraints. Serosal or mucosal electrodes have cables that traverse the abdominal wall, or a natural orifice, causing discomfort and possible infection, and restricting mobility. These problems motivated the development of a wireless system. The bidirectional telemetric system constitutes a front-end transponder, a back-end receiver and a graphical user interface. The front-end module conditions the analog signals, then digitizes and loads the data into a radio for transmission. Data receipt at the back-end is acknowledged via a transceiver function. The system was validated in a bench-top study, then validated in-vivo using serosal electrodes connected simultaneously to a commercial wired system. The front-end module was 35×35×27 mm3 and weighed 20 g. Bench-top tests demonstrated reliable communication within a distance range of 30 m, power consumption of 13.5 mW, and 124-hour operation when utilizing a 560-mAh, 3-V battery. In-vivo, slow wave frequencies were recorded identically with the wireless and wired reference systems (2.4 cycles/min), automated activation time detection was modestly better for the wireless system (5% vs 14% false positive rate), and signal amplitudes were modestly higher via the wireless system (462 vs 386 μV; p<0.001). This telemetric system for slow wave acquisition is reliable, power efficient, readily portable and potentially implantable. The device will enable chronic monitoring and evaluation of slow wave patterns in animals and patients. PMID:22635054

Predator-driven elemental cycling: the impact of predation and risk effects on ecosystem stoichiometry.

PubMed

Leroux, Shawn J; Schmitz, Oswald J

2015-11-01

Empirical evidence is beginning to show that predators can be important drivers of elemental cycling within ecosystems by propagating indirect effects that determine the distribution of elements among trophic levels as well as determine the chemical content of organic matter that becomes decomposed by microbes. These indirect effects can be propagated by predator consumptive effects on prey, nonconsumptive (risk) effects, or a combination of both. Currently, there is insufficient theory to predict how such predator effects should propagate throughout ecosystems. We present here a theoretical framework for exploring predator effects on ecosystem elemental cycling to encourage further empirical quantification. We use a classic ecosystem trophic compartment model as a basis for our analyses but infuse principles from ecological stoichiometry into the analyses of elemental cycling. Using a combined analytical-numerical approach, we compare how predators affect cycling through consumptive effects in which they control the flux of nutrients up trophic chains; through risk effects in which they change the homeostatic elemental balance of herbivore prey which accordingly changes the element ratio herbivores select from plants; and through a combination of both effects. Our analysis reveals that predators can have quantitatively important effects on elemental cycling, relative to a model formalism that excludes predator effects. Furthermore, the feedbacks due to predator nonconsumptive effects often have the quantitatively strongest impact on whole ecosystem elemental stocks, production and efficiency rates, and recycling fluxes by changing the stoichiometric balance of all trophic levels. Our modeling framework predictably shows how bottom-up control by microbes and top-down control by predators on ecosystems become interdependent when top predator effects permeate ecosystems.

Particle transport in DIII-D plasmas

NASA Astrophysics Data System (ADS)

Kress, Peter; Mordijck, Saskia

2017-10-01

By analyzing the plasma opacity and density evolution during the ELM cycle in DIII-D H-mode plasmas in which the amount of gas fueling was altered, we find evidence for an inward particle pinch at the plasma edge which seems to become more pronounced at higher density. Furthermore, at the plasma edge we find a correlation between the pedestal density and opacity, which measures neutral penetration depth. The changes in edge opacity during an ELM cycle were calculated by using a detailed time history of measured plasma profiles. At the same time, the density evolution during an ELM cycle was investigated. We find that if the edge density increases through an increase in gas fueling, then opacity increases and neutral fueling penetration depth decreases. We also find that density at the top of the pedestal recovers faster following an ELM when the overall density level is higher, leading to a hollow profile inside of the pedestal top. All these results indicate that there must be an inward particle pinch in the pedestal which will be crucial in the fueling of future burning plasma devices. Supported by US DOE DE-SC0007880, DIII-D Grant Number DE-FC02-04ER54698.

Non-iterative characterization of few-cycle laser pulses using flat-top gates.

PubMed

Selm, Romedi; Krauss, Günther; Leitenstorfer, Alfred; Zumbusch, Andreas

2012-03-12

We demonstrate a method for broadband laser pulse characterization based on a spectrally resolved cross-correlation with a narrowband flat-top gate pulse. Excellent phase-matching by collinear excitation in a microscope focus is exploited by degenerate four-wave mixing in a microscope slide. Direct group delay extraction of an octave spanning spectrum which is generated in a highly nonlinear fiber allows for spectral phase retrieval. The validity of the technique is supported by the comparison with an independent second-harmonic fringe-resolved autocorrelation measurement for an 11 fs laser pulse.

Flat-topped broadband rugate filters.

PubMed

Imenes, Anne G; McKenzie, David R

2006-10-20

A method of creating rugate interference filters that have flat-topped reflectance across an extended spectral region is presented. The method applies known relations from the classical coupled wave theory to develop a set of equations that gives the spatial frequency distribution of rugate cycles to achieve constant reflectance across a given spectral region. Two examples of the application of this method are discussed: a highly reflective coating for eye protection against harmful laser radiation incident from normal to 45 degrees , and a spectral beam splitter for efficient solar power conversion.

Annual Cycle of Cloud Forcing of Surface Radiation Budget

NASA Technical Reports Server (NTRS)

Wilber, Anne C.; Smith, G. Louis; Stackhouse, Paul W., Jr.; Gupta, Shashi K.

2006-01-01

The climate of the Earth is determined by its balance of radiation. The incoming and outgoing radiation fluxes are strongly modulated by clouds, which are not well understood. The Earth Radiation Budget Experiment (Barkstrom and Smith, 1986) provided data from which the effects of clouds on radiation at the top of the atmosphere (TOA) could be computed (Ramanathan, 1987). At TOA, clouds increase the reflected solar radiation, tending to cool the planet, and decrease the OLR, causing the planet to retain its heat (Ramanathan et al., 1989; Harrison et al., 1990). The effects of clouds on radiation fluxes are denoted cloud forcing. These shortwave and longwave forcings counter each other to various degrees, so that in the tropics the result is a near balance. Over mid and polar latitude oceans, cloud forcing at TOA results in large net loss of radiation. Here, there are large areas of stratus clouds and cloud systems associated with storms. These systems are sensitive to surface temperatures and vary strongly with the annual cycle. During winter, anticyclones form over the continents and move to the oceans during summer. This movement of major cloud systems causes large changes of surface radiation, which in turn drives the surface temperature and sensible and latent heat released to the atmosphere.

Nano-porous electrode systems by colloidal lithography for sensitive electrochemical detection: fabrication technology and properties

NASA Astrophysics Data System (ADS)

Lohmüller, Theobald; Müller, Ulrich; Breisch, Stefanie; Nisch, Wilfried; Rudorf, Ralf; Schuhmann, Wolfgang; Neugebauer, Sebastian; Kaczor, Markus; Linke, Stephan; Lechner, Sebastian; Spatz, Joachim; Stelzle, Martin

2008-11-01

A porous metal-insulator-metal sensor system was developed with the ultimate goal of enhancing the sensitivity of electrochemical sensors by taking advantage of redox cycling of electro active molecules between closely spaced electrodes. The novel fabrication technology is based on thin film deposition in combination with colloidal self-assembly and reactive ion etching to create micro- or nanopores. This cost effective approach is advantageous compared to common interdigitated electrode arrays (IDA) since it does not require high definition lithography technology. Spin-coating and random particle deposition, combined with a new sublimation process are discussed as competing strategies to generate monolayers of colloidal spheres. Metal-insulator-metal layer systems with low leakage currents < 10 pA and an insulator thickness as low as 100 nm were obtained at high yield (typically > 90%). We also discuss possible causes of sensor failure with respect to critical fabrication processes. Short circuits which could occur during or as a result of the pore etching process were investigated in detail. Infrared microscopy in combination with focused ion beam etching/SEM were used to reveal a defect mechanism creating interconnects and increased leakage current between the top and bottom electrodes. Redox cycling provides for amplification factors of >100. A general applicability for electrochemical diagnostic assays is therefore anticipated.

Preparation and Thermoelectric Characteristics of ITO/PtRh:PtRh Thin Film Thermocouple

NASA Astrophysics Data System (ADS)

Zhao, Xiaohui; Wang, Hongmin; Zhao, Zixiang; Zhang, Wanli; Jiang, Hongchuan

2017-12-01

Thin film thermocouples (TFTCs) can provide more precise in situ temperature measurement for aerospace propulsion systems without disturbance of gas flow and surface temperature distribution of the hot components. ITO /PtRh:PtRh TFTC with multilayer structure was deposited on alumina ceramic substrate by magnetron sputtering. After annealing, the TFTC was statically calibrated for multiple cycles with temperature up to 1000 °C. The TFTC with excellent stability and repeatability was realized for the negligible variation of EMF in different calibration cycles. It is believed that owing to oxygen diffusion barriers by the oxidation of top PtRh layer and Schottky barriers formed at the grain boundaries of ITO, the variation of the carrier concentration of ITO film is minimized. Meanwhile, the life time of TFTC is more than 30 h in harsh environment. This makes ITO/PtRh:PtRh TFTC a promising candidate for precise surface temperature measurement of hot components of aeroengines.

Aligned carbon nanotube/zinc oxide nanowire hybrids as high performance electrodes for supercapacitor applications

NASA Astrophysics Data System (ADS)

Al-Asadi, Ahmed S.; Henley, Luke Alexander; Wasala, Milinda; Muchharla, Baleeswaraiah; Perea-Lopez, Nestor; Carozo, Victor; Lin, Zhong; Terrones, Mauricio; Mondal, Kanchan; Kordas, Krisztian; Talapatra, Saikat

2017-03-01

Carbon nanotube/metal oxide based hybrids are envisioned as high performance electrochemical energy storage electrodes since these systems can provide improved performances utilizing an electric double layer coupled with fast faradaic pseudocapacitive charge storage mechanisms. In this work, we show that high performance supercapacitor electrodes with a specific capacitance of ˜192 F/g along with a maximum energy density of ˜3.8 W h/kg and a power density of ˜ 28 kW/kg can be achieved by synthesizing zinc oxide nanowires (ZnO NWs) directly on top of aligned multi-walled carbon nanotubes (MWCNTs). In comparison to pristine MWCNTs, these constitute a 12-fold of increase in specific capacitance as well as corresponding power and energy density values. These electrodes also possess high cycling stability and were able to retain ˜99% of their specific capacitance value over 2000 charging discharging cycles. These findings indicate potential use of a MWCNT/ZnO NW hybrid material for future electrochemical energy storage applications.

Preparation and Thermoelectric Characteristics of ITO/PtRh:PtRh Thin Film Thermocouple.

PubMed

Zhao, Xiaohui; Wang, Hongmin; Zhao, Zixiang; Zhang, Wanli; Jiang, Hongchuan

2017-12-15

Thin film thermocouples (TFTCs) can provide more precise in situ temperature measurement for aerospace propulsion systems without disturbance of gas flow and surface temperature distribution of the hot components. ITO/PtRh:PtRh TFTC with multilayer structure was deposited on alumina ceramic substrate by magnetron sputtering. After annealing, the TFTC was statically calibrated for multiple cycles with temperature up to 1000 °C. The TFTC with excellent stability and repeatability was realized for the negligible variation of EMF in different calibration cycles. It is believed that owing to oxygen diffusion barriers by the oxidation of top PtRh layer and Schottky barriers formed at the grain boundaries of ITO, the variation of the carrier concentration of ITO film is minimized. Meanwhile, the life time of TFTC is more than 30 h in harsh environment. This makes ITO/PtRh:PtRh TFTC a promising candidate for precise surface temperature measurement of hot components of aeroengines.

Tank waste remediation system functions and requirements document

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carpenter, K.E

1996-10-03

This is the Tank Waste Remediation System (TWRS) Functions and Requirements Document derived from the TWRS Technical Baseline. The document consists of several text sections that provide the purpose, scope, background information, and an explanation of how this document assists the application of Systems Engineering to the TWRS. The primary functions identified in the TWRS Functions and Requirements Document are identified in Figure 4.1 (Section 4.0) Currently, this document is part of the overall effort to develop the TWRS Functional Requirements Baseline, and contains the functions and requirements needed to properly define the top three TWRS function levels. TWRS Technicalmore » Baseline information (RDD-100 database) included in the appendices of the attached document contain the TWRS functions, requirements, and architecture necessary to define the TWRS Functional Requirements Baseline. Document organization and user directions are provided in the introductory text. This document will continue to be modified during the TWRS life-cycle.« less

The implications of dust ice nuclei effect on cloud top temperature in a complex mesoscale convective system.

PubMed

Li, Rui; Dong, Xue; Guo, Jingchao; Fu, Yunfei; Zhao, Chun; Wang, Yu; Min, Qilong

2017-10-23

Mineral dust is the most important natural source of atmospheric ice nuclei (IN) which may significantly mediate the properties of ice cloud through heterogeneous nucleation and lead to crucial impacts on hydrological and energy cycle. The potential dust IN effect on cloud top temperature (CTT) in a well-developed mesoscale convective system (MCS) was studied using both satellite observations and cloud resolving model (CRM) simulations. We combined satellite observations from passive spectrometer, active cloud radar, lidar, and wind field simulations from CRM to identify the place where ice cloud mixed with dust particles. For given ice water path, the CTT of dust-mixed cloud is warmer than that in relatively pristine cloud. The probability distribution function (PDF) of CTT for dust-mixed clouds shifted to the warmer end and showed two peaks at about -45 °C and -25 °C. The PDF for relatively pristine cloud only show one peak at -55 °C. Cloud simulations with different microphysical schemes agreed well with each other and showed better agreement with satellite observations in pristine clouds, but they showed large discrepancies in dust-mixed clouds. Some microphysical schemes failed to predict the warm peak of CTT related to heterogeneous ice formation.

Real-time investigation of human topoisomerase I reaction kinetics using an optical sensor: a fast method for drug screening and determination of active enzyme concentrations

NASA Astrophysics Data System (ADS)

Kristoffersen, Emil L.; Jørgensen, Line A.; Franch, Oskar; Etzerodt, Michael; Frøhlich, Rikke; Bjergbæk, Lotte; Stougaard, Magnus; Ho, Yi-Ping; Knudsen, Birgitta R.

2015-05-01

Human DNA topoisomerase I (hTopI) is a nuclear enzyme that catalyzes relaxation of super helical tension that arises in the genome during essential DNA metabolic processes. This is accomplished through a common reaction mechanism shared among the type IB topoisomerase enzymes, including eukaryotic and poxvirus topoisomerase I. The mechanism of hTopI is specifically targeted in cancer treatment using camptothecin derivatives. These drugs convert the hTopI activity into a cellular poison, and hence the cytotoxic effects of camptothecin derivatives correlate with the hTopI activity. Therefore, fast and reliable techniques for high throughput measurements of hTopI activity are of high clinical interest. Here we demonstrate potential applications of a fluorophore-quencher based DNA sensor designed for measurement of hTopI cleavage-ligation activities, which are the catalytic steps affected by camptothecin. The kinetic analysis of the hTopI reaction with the DNA sensor exhibits a characteristic burst profile. This is the result of a two-step ping-pong reaction mechanism, where a fast first reaction, the one creating the signal, is followed by a slower second reaction necessary for completion of the catalytic cycle. Hence, the burst profile holds information about two reactions in the enzymatic mechanism. Moreover, it allows the amount of active enzyme in the reaction to be determined. The presented results pave the way for future high throughput drug screening and the potential of measuring active hTopI concentrations in clinical samples for individualized treatment.Human DNA topoisomerase I (hTopI) is a nuclear enzyme that catalyzes relaxation of super helical tension that arises in the genome during essential DNA metabolic processes. This is accomplished through a common reaction mechanism shared among the type IB topoisomerase enzymes, including eukaryotic and poxvirus topoisomerase I. The mechanism of hTopI is specifically targeted in cancer treatment using camptothecin derivatives. These drugs convert the hTopI activity into a cellular poison, and hence the cytotoxic effects of camptothecin derivatives correlate with the hTopI activity. Therefore, fast and reliable techniques for high throughput measurements of hTopI activity are of high clinical interest. Here we demonstrate potential applications of a fluorophore-quencher based DNA sensor designed for measurement of hTopI cleavage-ligation activities, which are the catalytic steps affected by camptothecin. The kinetic analysis of the hTopI reaction with the DNA sensor exhibits a characteristic burst profile. This is the result of a two-step ping-pong reaction mechanism, where a fast first reaction, the one creating the signal, is followed by a slower second reaction necessary for completion of the catalytic cycle. Hence, the burst profile holds information about two reactions in the enzymatic mechanism. Moreover, it allows the amount of active enzyme in the reaction to be determined. The presented results pave the way for future high throughput drug screening and the potential of measuring active hTopI concentrations in clinical samples for individualized treatment. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr01474c

Evolution of the lithium morphology from cycling of thin film solid state batteries

DOE PAGES

Dudney, Nancy J.

2017-03-11

Thin film batteries with a Lipon electrolyte and Li metal anode can be cycled thousands of times. During this time there is a gradual redistribution of the lithium at the top surface; the morphology that develops depends on a number of factors but is largely driven by dewetting. In this work, this redistribution is characterized as functions of the cycle number, duty cycle, cathode composition, and protective coating over the lithium. Observations of wrinkled and pitted surfaces are discussed considering the effects of defects and diffusion in the lithium and influences of film stresses and surface energy. In conclusion, similarmore » processes may impact solid state lithium batteries with higher energy per active area.« less

Evolution of the lithium morphology from cycling of thin film solid state batteries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dudney, Nancy J.

Thin film batteries with a Lipon electrolyte and Li metal anode can be cycled thousands of times. During this time there is a gradual redistribution of the lithium at the top surface; the morphology that develops depends on a number of factors but is largely driven by dewetting. In this work, this redistribution is characterized as functions of the cycle number, duty cycle, cathode composition, and protective coating over the lithium. Observations of wrinkled and pitted surfaces are discussed considering the effects of defects and diffusion in the lithium and influences of film stresses and surface energy. In conclusion, similarmore » processes may impact solid state lithium batteries with higher energy per active area.« less

User interface techniques in the counseling module of TOPS (Transportation Operational Personal Property Standard)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yow, T.G.

The Transportation Operational Personal Property Standard System (TOPS) is an automated information management system to help administer the personal property transporation program for the Department of Defense (DOD). TOPS was fielded at four prototype sites in the late summer of 1988. Prototype testing is currently underway, with system deployment scheduled for 1989. When fully deployed, TOPS will save DOD both time and money and help ensure that all shipments made by armed services personnel are handled quickly and efficiently. The success of the TOPS system depends upon several key factors. Of course, TOPS must give transportation clerks at military personalmore » property shipping offices a tool with which they can perform their jobs with greater ease, speed, and correctness. However, before TOPS can achieve success in the field, it must first find acceptance from the transportation clerks themselves. The purpose of this document is to examine the user interface techniques used in the Counseling module of TOPS to ensure user acceptance and data base integrity, both key elements in the ultimate success of TOPS. 6 refs., 12 figs.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bae, Soo Kyung; Gwak, Jungsug; Song, Im-Sook

Highlights: {yields} TopIn activates p53-dependent transcription in colon cancer cells. {yields} TopIn induces apoptosis in colon cancer cells. {yields} TopIn selectively inhibits topoisomerase I activity. {yields} TopIn does not affect the activity of BCRP and MDR-1. -- Abstract: The tumor suppressor p53 plays an important role in cellular emergency mechanisms through regulating the genes involved in cell cycle arrest and apoptosis. To identify small molecules that can activate p53-responsive transcription, we performed chemical screening using genetically engineered HCT116 reporter cells. We found that TopIn (7-phenyl-6H-[1,2,5]oxadiazolo[3,4-e]indole 3-oxide) efficiently activated p53-mediated transcriptional activity and induced phosphorylation of p53 at Ser15, thereby stabilizingmore » the p53 protein. Furthermore, TopIn upregulated the expression of p21{sup WAF1/CIP1}, a downstream target of p53, and suppressed cellular proliferation in various colon cancer cells. Additionally, TopIn induced DNA fragmentation, caspase-3/7 activation and poly ADP ribose polymerase cleavage, typical biochemical markers of apoptosis, in p53 wild-type and mutated colon cancer cells. Finally, we found that TopIn inhibited topoisomerase I activity, but not topoisomerase II, in vitro and induced the formation of the topoisomerase I-DNA complex in HCT116 colon cancer cells. Unlike camptothecin (CPT) and its derivative SN38, TopIn did not affect the activity of the ATP-binding cassette transporter breast cancer resistance protein (BCRP) or multidrug-resistant protein-1 (MDR-1). These results suggest that TopIn may present a promising new topoisomerase I-targeting anti-tumor therapeutics.« less

Experiments on water detritiation and cryogenic distillation at TLK; Impact on ITER fuel cycle subsystems interfaces

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cristescu, I.; Cristescu, I. R.; Doerr, L.

2008-07-15

The ITER Isotope Separation System (ISS) and Water Detritiation System (WDS) should be integrated in order to reduce potential chronic tritium emissions from the ISS. This is achieved by routing the top (protium) product from the ISS to a feed point near the bottom end of the WDS Liquid Phase Catalytic Exchange (LPCE) column. This provides an additional barrier against ISS emissions and should mitigate the memory effects due to process parameter fluctuations in the ISS. To support the research activities needed to characterize the performances of various components for WDS and ISS processes under various working conditions and configurationsmore » as needed for ITER design, an experimental facility called TRENTA representative of the ITER WDS and ISS protium separation column, has been commissioned and is in operation at TLK The experimental program on TRENTA facility is conducted to provide the necessary design data related to the relevant ITER operating modes. The operation availability and performances of ISS-WDS have impact on ITER fuel cycle subsystems with consequences on the design integration. The preliminary experimental data on TRENTA facility are presented. (authors)« less

Nitrogen-Doped Mesoporous Carbon: A Top-Down Strategy to Promote Sulfur Immobilization for Lithium-Sulfur Batteries.

PubMed

Zhao, Xiaohui; Liu, Ying; Manuel, James; Chauhan, Ghanshyam S; Ahn, Hyo-Jun; Kim, Ki-Won; Cho, Kwon-Koo; Ahn, Jou-Hyeon

2015-10-12

The loss of active sulfur material is a challenge in the application of lithium-sulfur (Li-S) batteries. To immobilize sulfur, a nitrogen-doped mesoporous carbon (PMC) was synthesized with polyaniline (PANi) as the carbon source, which was used for development of Li-S batteries. The nitrogen content and pore system of the PMCs were modulated by varying the pyrolysis temperature to impart good electrochemical properties to the Li-S cells. As a result, the optimal capacity reversibility was obtained with the PMC synthesized at 700 °C that consisted of 12.8 % nitrogen. The enhanced cycle performance of Li-S cells was also validated at high sulfur contents up to 70 % and high C-rates up to 2 C. Furthermore, such sulfur/PMC cathodes could alleviate volume expansion during the discharge process. The results suggest that our synthesized nitrogen-doped PMCs prepared by this top-down strategy are promising materials to immobilize active sulfur in Li-S batteries. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Altered invertase activities of symptomatic tissues on Beet severe curly top virus (BSCTV) infected Arabidopsis thaliana.

PubMed

Park, Jungan; Kim, Soyeon; Choi, Eunseok; Auh, Chung-Kyun; Park, Jong-Bum; Kim, Dong-Giun; Chung, Young-Jae; Lee, Taek-Kyun; Lee, Sukchan

2013-09-01

Arabidopsis thaliana infected with Beet severe curly top virus (BSCTV) exhibits systemic symptoms such as stunting of plant growth, callus induction on shoot tips, and curling of leaves and shoot tips. The regulation of sucrose metabolism is essential for obtaining the energy required for viral replication and the development of symptoms in BSCTV-infected A. thaliana. We evaluated the changed transcript level and enzyme activity of invertases in the inflorescence stems of BSCTV-infected A. thaliana. These results were consistent with the increased pattern of ribulose-1,5-bisphosphate carboxylase/oxygenase activity and photosynthetic pigment concentration in virus-infected plants to supply more energy for BSCTV multiplication. The altered gene expression of invertases during symptom development was functionally correlated with the differential expression patterns of D-type cyclins, E2F isoforms, and invertase-related genes. Taken together, our results indicate that sucrose sensing by BSCTV infection may regulate the expression of sucrose metabolism and result in the subsequent development of viral symptoms in relation with activation of cell cycle regulation.

Accidental Beam Losses and Protection in the LHC

NASA Astrophysics Data System (ADS)

Schmidt, R.; Working Group On Machine Protection

2005-06-01

At top energy (proton momentum 7 TeV/c) with nominal beam parameters, each of the two LHC proton beams has a stored energy of 350 MJ threatening to damage accelerator equipment in case of accidental beam loss. It is essential that the beams are properly extracted onto the dump blocks in case of failure since these are the only elements that can withstand full beam impact. Although the energy stored in the beams at injection (450 GeV/c) is about 15 times smaller compared to top energy, the beams must still be properly extracted in case of large accidental beam losses. Failures must be detected at a sufficiently early stage and initiate a beam dump. Quenches and power converter failures will be detected by monitoring the correct functioning of the hardware systems. In addition, safe operation throughout the cycle requires the use of beam loss monitors, collimators and absorbers. Ideas of detection of fast beam current decay, monitoring of fast beam position changes and monitoring of fast magnet current changes are discussed, to provide the required redundancy for machine protection.

Evaluation of the FEERv1.0 Global Top-Down Biomass Burning Emissions Inventory over Africa

NASA Astrophysics Data System (ADS)

Ellison, L.; Ichoku, C. M.

2014-12-01

With the advent of the Fire Energetics and Emissions Research (FEER) global top-down biomass burning emissions product from NASA Goddard Space Flight Center, a subsequent effort is going on to analyze and evaluate some of the main (particulate and gaseous) constituents of this emissions inventory against other inventories of biomass burning emissions over the African continent. There is consistent and continual burning during the dry season in NSSA of many small slash-and-burn fires that, though may be relatively small fires individually, collectively contribute 20-25% of the global total carbon emissions from biomass burning. As a top-down method of estimating biomass-burning emissions, FEERv1.0 is able to yield higher and more realistic emissions than previously obtainable using bottom-up methods. Results of such comparisons performed in detail over Africa will be discussed in this presentation. This effort is carried out in conjunction with a NASA-funded interdisciplinary research project investigating the effects of biomass burning on the regional climate system in Northern Sub-Saharan Africa (NSSA). Essentially, that project aims to determine how fires may have affected the severe droughts that plagued the NSSA region in recent history. Therefore, it is imperative that the biomass burning emissions input data over Africa be as accurate as possible in order to obtain a confident understanding of their interactions and feedbacks with the hydrological cycle in NSSA.

High-energy ultra-short pulse thin-disk lasers: new developments and applications

NASA Astrophysics Data System (ADS)

Michel, Knut; Klingebiel, Sandro; Schultze, Marcel; Tesseit, Catherine Y.; Bessing, Robert; Häfner, Matthias; Prinz, Stefan; Sutter, Dirk; Metzger, Thomas

2016-03-01

We report on the latest developments at TRUMPF Scientific Lasers in the field of ultra-short pulse lasers with highest output energies and powers. All systems are based on the mature and industrialized thin-disk technology of TRUMPF. Thin Yb:YAG disks provide a reliable and efficient solution for power and energy scaling to Joule- and kW-class picosecond laser systems. Due to its efficient one dimensional heat removal, the thin-disk exhibits low distortions and thermal lensing even when pumped under extremely high pump power densities of 10kW/cm². Currently TRUMPF Scientific Lasers develops regenerative amplifiers with highest average powers, optical parametric amplifiers and synchronization schemes. The first few-ps kHz multi-mJ thin-disk regenerative amplifier based on the TRUMPF thindisk technology was developed at the LMU Munich in 20081. Since the average power and energy have continuously been increased, reaching more than 300W (10kHz repetition rate) and 200mJ (1kHz repetition rate) at pulse durations below 2ps. First experiments have shown that the current thin-disk technology supports ultra-short pulse laser solutions >1kW of average power. Based on few-picosecond thin-disk regenerative amplifiers few-cycle optical parametric chirped pulse amplifiers (OPCPA) can be realized. These systems have proven to be the only method for scaling few-cycle pulses to the multi-mJ energy level. OPA based few-cycle systems will allow for many applications such as attosecond spectroscopy, THz spectroscopy and imaging, laser wake field acceleration, table-top few-fs accelerators and laser-driven coherent X-ray undulator sources. Furthermore, high-energy picosecond sources can directly be used for a variety of applications such as X-ray generation or in atmospheric research.

Impact on Water Heater Performance of Heating Methods that Promote Tank Temperature Stratification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gluesenkamp, Kyle R; BushPE, John D

2016-01-01

During heating of a water heater tank, the vertical temperature stratification of the water can be increased or decreased, depending on the method of heating. Methods that increase stratification during heating include (1) removing cold water from the tank bottom, heating it, and re-introducing it to the tank top at relatively low flow rate, (2) using a heat exchanger wrapped around the tank, through which heating fluid (with finite specific heat) flows from top to bottom, and (3) using an immersed heat element that is relatively high in the tank. Using such methods allows for improved heat pump water heatermore » (HPWH) cycle efficiencies when the heat pump can take advantage of the lower temperatures that exist lower in the tank, and accommodate the resulting glide. Transcritical cycles are especially well-suited to capitalize on this opportunity, and other HPWH configurations (that have been proposed elsewhere) may benefit as well. This work provides several stratification categories of heat pump water heater tank configurations relevant to their stratification potential. To illustrate key differences among categories, it also compiles available experimental data for (a) single pass pumped flow, (b) multi-pass pumped flow, and (c) top-down wrapped tank with transcritical refrigerant.« less

The Effect of Interface Roughness and Oxide Film Thickness on the Inelastic Response of Thermal Barrier Coatings to Thermal Cycling

NASA Technical Reports Server (NTRS)

Pindera, Marek-Jerzy; Aboudi, Jacob; Arnold, Steven M.

1999-01-01

The effects of interfacial roughness and oxide film thickness on thermally-induced stresses in plasma-sprayed thermal barrier coatings subjected to thermal cycling are investigated using the recently developed higher-order theory for functionally graded materials. The higher-order theory is shown to be a viable alternative to the finite-element approach, capable of modeling different interfacial roughness architectures in the presence of an aluminum oxide layer and capturing the high stress gradients that occur at the top coat/bond coat interface. The oxide layer thickness is demonstrated to have a substantially greater effect on the evolution of residual stresses than local variations in interfacial roughness. Further, the location of delamination initiation in the top coat is predicted to change with increasing oxide layer thickness. This result can be used to optimize the thickness of a pre-oxidized layer introduced at the top coat/bond coat interface in order to enhance TBC durability as suggested by some researchers. The results of our investigation also support a recently proposed hypothesis regarding delamination initiation and propagation in the presence of an evolving bond coat oxidation, while pointing to the importance of interfacial roughness details and specimen geometry in modeling this phenomenon.

The effect of environment on thermal barrier coating lifetime

DOE PAGES

Pint, Bruce A.; Unocic, Kinga A.; Haynes, James Allen

2016-03-15

While the water vapor content of the combustion gas in natural gas-fired land-based turbines is ~10%, it can be 20–85% with coal-derived (syngas or H 2) fuels or innovative turbine concepts for more efficient carbon capture. Additional concepts envisage working fluids with high CO 2 contents to facilitate carbon capture and sequestration. To investigate the effects of changes in the gas composition on thermal barrier coating (TBC) lifetime, furnace cycling tests (1-h and 100-h cycles) were performed in air with 10, 50, and 90 vol. % water vapor and CO 2-10% H 2O and compared to prior results in drymore » air or O 2. Two types of TBCs were investigated: (1) diffusion bond coatings (Pt-diffusion or Pt-modified aluminide) with commercial electron-beam physical vapor-deposited yttria-stabilized zirconia (YSZ) top coatings on second-generation superalloy N5 and N515 substrates and (2) high-velocity oxygen fuel (HVOF) sprayed MCrAlYHfSi bond coatings with air plasma-sprayed YSZ top coatings on superalloys X4, 1483, or 247 substrates. For both types of coatings exposed in 1-h cycles, the addition of water vapor resulted in a decrease in coating lifetime, except for Pt-diffusion coatings which were unaffected by the environment. In 100-h cycles, environment was less critical, perhaps because coating failure was chemical (i.e., due to interdiffusion) rather than mechanical. As a result, in both 1-h and 100-h cycles, CO 2 did not appear to have any negative effect on coating lifetime.« less

Low Fatigue in Epitaxial Pb(Zr0.2Ti0.8)O3 on Si Substrates with LaNiO3 Electrodes by RF Sputtering

NASA Astrophysics Data System (ADS)

Wang, Chun; Kryder, Mark H.

2009-09-01

Epitaxial PZT (001) thin films with a LaNiO3 bottom electrode were deposited by radio-frequency (RF) sputtering onto Si(001) single-crystal substrates with SrTiO3/TiN buffer layers. Pb(Zr0.2Ti0.8)O3 (PZT) samples were shown to consist of a single perovskite phase and to have an (001) orientation. The orientation relationship was determined to be PZT(001)[110]∥LaNiO3(001)[110]∥SrTiO3 (001)[110]∥TiN(001)[110]∥Si(001)[110]. Atomic force microscope (AFM) measurements showed the PZT films to have smooth surfaces with a roughness of 1.15 nm. The microstructure of the multilayer was studied using transmission electron microscopy (TEM). Electrical measurements were conducted using both Pt and LaNiO3 as top electrodes. The measured remanent polarization P r and coercive field E c of the PZT thin film with Pt top electrodes were 23 μC/cm2 and 75 kV/cm, and were 25 μC/cm2 and 60 kV/cm for the PZT film with LaNiO3 top electrodes. No obvious fatigue after 1010 switching cycles indicated good electrical endurance of the PZT films using LaNiO3 electrodes, compared with the PZT film with Pt top electrodes showing a significant polarization loss after 108 cycles. These PZT films with LaNiO3 electrodes could be potential recording media for probe-based high-density data storage.

Internal combustion engine using premixed combustion of stratified charges

DOEpatents

Marriott, Craig D [Rochester Hills, MI; Reitz, Rolf D [Madison, WI

2003-12-30

During a combustion cycle, a first stoichiometrically lean fuel charge is injected well prior to top dead center, preferably during the intake stroke. This first fuel charge is substantially mixed with the combustion chamber air during subsequent motion of the piston towards top dead center. A subsequent fuel charge is then injected prior to top dead center to create a stratified, locally richer mixture (but still leaner than stoichiometric) within the combustion chamber. The locally rich region within the combustion chamber has sufficient fuel density to autoignite, and its self-ignition serves to activate ignition for the lean mixture existing within the remainder of the combustion chamber. Because the mixture within the combustion chamber is overall premixed and relatively lean, NO.sub.x and soot production are significantly diminished.

Airborne Antenna System for Minimum-Cycle-Slip GPS Reception

NASA Technical Reports Server (NTRS)

Wright, C. Wayne

2009-01-01

A system that includes a Global Positioning System (GPS) antenna and associated apparatus for keeping the antenna aimed upward has been developed for use aboard a remote-sensing-survey airplane. The purpose served by the system is to enable minimum- cycle-slip reception of GPS signals used in precise computation of the trajectory of the airplane, without having to restrict the airplane to maneuvers that increase the flight time needed to perform a survey. Cycle slip signifies loss of continuous track of the phase of a signal. Minimum-cycle-slip reception is desirable because maintaining constant track of the phase of the carrier signal from each available GPS satellite is necessary for surveying to centimeter or subcentimeter precision. Even a loss of signal for as short a time as a nanosecond can cause cycle slip. Cycle slips degrade the quality and precision of survey data acquired during a flight. The two principal causes of cycle slip are weakness of signals and multipath propagation. Heretofore, it has been standard practice to mount a GPS antenna rigidly on top of an airplane, and the radiation pattern of the antenna is typically hemispherical, so that all GPS satellites above the horizon are viewed by the antenna during level flight. When the airplane must be banked for a turn or other maneuver, the reception hemisphere becomes correspondingly tilted; hence, the antenna no longer views satellites that may still be above the Earth horizon but are now below the equatorial plane of the tilted reception hemisphere. Moreover, part of the reception hemisphere (typically, on the inside of a turn) becomes pointed toward ground, with a consequent increase in received noise and, therefore, degradation of GPS measurements. To minimize the likelihood of loss of signal and cycle slip, bank angles of remote-sensing survey airplanes have generally been limited to 10 or less, resulting in skidding or slipping uncoordinated turns. An airplane must be banked in order to make a coordinated turn. For small-radius, short-time coordinated turns, it is necessary to employ banks as steep as 45 , and turns involving such banks are times and for confining airplanes as closely as possible to areas to be surveyed. The idea underlying the design is that if the antenna can be kept properly aimed, then the incidence of cycle slips caused by loss or weakness of signals can be minimized. The system includes an articulating GPS antenna and associated electronic circuitry mounted under a radome atop an airplane. The electronic circuitry includes a microprocessor-based interface-circuit-and-data-translation module. The system receives data on the current attitude of the airplane from the inertial navigation system of the airplane. The microprocessor decodes the attitude data and uses them to compute commands for the GPS-antenna-articulating mechanism to tilt the antenna, relative to the airplane, in opposition to the roll or bank of the airplane to keep the antenna pointed toward the zenith. The system was tested aboard the hurricane- hunting airplane of the National Oceanic and Atmospheric Administration (NOAA) [see figure] during an 11-hour flight to observe the landfall of Hurricane Bret in late summer of 1999. No bank-angle restrictions were imposed during the flight. Post-flight analysis of the GPS trajectory data revealed that no cycle slip had occurred.considered normal maneuvers. These steep banks are highly desirable for minimizing flight

Old-growth forests can accumulate carbon in soils

USGS Publications Warehouse

Zhou, G.; Liu, S.; Li, Z.; Zhang, Dongxiao; Tang, X.; Zhou, C.; Yan, J.; Mo, J.

2006-01-01

Old-growth forests have traditionally been considered negligible as carbon sinks because carbon uptake has been thought to be balanced by respiration. We show that the top 20-centimeter soil layer in preserved old-growth forests in southern China accumulated atmospheric carbon at an unexpectedly high average rate of 0.61 megagrams of carbon hectare-1 year-1 from 1979 to 2003. This study suggests that the carbon cycle processes in the belowground system of these forests are changing in response to the changing environment. The result directly challenges the prevailing belief in ecosystem ecology regarding carbon budget in old-growth forests and supports the establishment of a new, nonequilibrium conceptual framework to study soil carbon dynamics.

Modeling Oxidation Induced Stresses in Thermal Barrier Coatings

NASA Technical Reports Server (NTRS)

Ferguson, B. L.; Freborg, A. M.; Petrus, G. J.; Brindley, William J.

1998-01-01

The use of thermal barrier coatings (TBC's) in gas turbines has increased dramatically in recent years, due mainly to the need for component protection from ever increasing service temperatures. Oxidation of the bond coat has been identified as an important contributing factor to spallation of the ceramic top coat during service. Additional variables found to influence TBC thermal cycle life include bond coat coefficient of thermal expansion, creep behavior of both the ceramic and bond coat layers, and modulus of elasticity. The purpose of this work was to characterize the effects of oxidation on the stress states within the TBC system, as well as to examine the interaction of oxidation with other factors affecting TBC life.

Thermodynamic and design considerations of organic Rankine cycles in combined application with a solar thermal gas turbine

NASA Astrophysics Data System (ADS)

Braun, R.; Kusterer, K.; Sugimoto, T.; Tanimura, K.; Bohn, D.

2013-12-01

Concentrated Solar Power (CSP) technologies are considered to provide a significant contribution for the electric power production in the future. Different kinds of technologies are presently in operation or under development, e.g. parabolic troughs, central receivers, solar dish systems and Fresnel reflectors. This paper takes the focus on central receiver technologies, where the solar radiation is concentrated by a field of heliostats in a receiver on the top of a tall tower. To get this CSP technology ready for the future, the system costs have to reduce significantly. The main cost driver in such kind of CSP technologies are the huge amount of heliostats. To reduce the amount of heliostats, and so the investment costs, the efficiency of the energy conversion cycle becomes an important issue. An increase in the cycle efficiency results in a decrease of the solar heliostat field and thus, in a significant cost reduction. The paper presents the results of a thermodynamic model of an Organic Rankine Cycle (ORC) for combined cycle application together with a solar thermal gas turbine. The gas turbine cycle is modeled with an additional intercooler and recuperator and is based on a typical industrial gas turbine in the 2 MW class. The gas turbine has a two stage radial compressor and a three stage axial turbine. The compressed air is preheated within a solar receiver to 950°C before entering the combustor. A hybrid operation of the gas turbine is considered. In order to achieve a further increase of the overall efficiency, the combined operation of the gas turbine and an Organic Rankine Cycle is considered. Therefore an ORC has been set up, which is thermally connected to the gas turbine cycle at two positions. The ORC can be coupled to the solar-thermal gas turbine cycle at the intercooler and after the recuperator. Thus, waste heat from different cycle positions can be transferred to the ORC for additional production of electricity. Within this investigation different working fluids and ORC conditions have been analyzed in order to evaluate the best configuration. The investigations have been performed by application of improved thermodynamic and process analysis tools, which consider the real gas behavior of the analyzed fluids. The results show that by combined operation of the solar thermal gas turbine and the ORC, the combined cycle efficiency is approximately 4%-points higher than in the solar-thermal gas turbine cycle.

TOPS: Toward Other Planetary Systems. A report by the solar system exploration division

NASA Technical Reports Server (NTRS)

1995-01-01

This report describes a general plan and the pertinent technological requirements for TOPS (Toward Other Planetary Systems), a staged program to ascertain the prevalence and character of other planetary systems and to construct a definitive picture of the formation of stars and their planets. The first stages focus on discovering and studying a significant number of fully formed planetary systems, as well as expanding current studies of protoplanetary systems. As the TOPS Program evolves, emphasis will shift toward intensive study of the discovered systems and of individual planets. Early stages of the TOPS Program can be undertaken with ground-based observations and space missions comparable in scale to those now being performed. In the long term, however, TOPS will become an ambitious program that challenges our capabilities and provides impetus for major space initiatives and new technologies.

Relating rainfall characteristics to cloud top temperatures at different scales

NASA Astrophysics Data System (ADS)

Klein, Cornelia; Belušić, Danijel; Taylor, Christopher

2017-04-01

Extreme rainfall from mesoscale convective systems (MCS) poses a threat to lives and livelihoods of the West African population through increasingly frequent devastating flooding and loss of crops. However, despite the significant impact of such extreme events, the dominant processes favouring their occurrence are still under debate. In the data-sparse West African region, rainfall radar data from the Tropical Rainfall Measuring Mission (TRMM) gives invaluable information on the distribution and frequency of extreme rainfall. The TRMM 2A25 product provides a 15-year dataset of snapshots of surface rainfall from 2-4 overpasses per day. Whilst this sampling captures the overall rainfall characteristics, it is neither long nor frequent enough to diagnose changes in MCS properties, which may be linked to the trend towards rainfall intensification in the region. On the other hand, Meteosat geostationary satellites provide long-term sub-hourly records of cloud top temperatures, raising the possibility of combining these with the high-quality rainfall data from TRMM. In this study, we relate TRMM 2A25 rainfall to Meteosat Second Generation (MSG) cloud top temperatures, which are available from 2004 at 15 minutes intervals, to get a more detailed picture of the structure of intense rainfall within the life cycle of MCS. We find TRMM rainfall intensities within an MCS to be strongly coupled with MSG cloud top temperatures: the probability for extreme rainfall increases from <10% for minimum temperatures warmer than -40°C to over 70% when temperatures drop below -70°C, confirming the potential in analysing cloud-top temperatures as a proxy for extreme rain. The sheer size of MCS raises the question which scales of sub-cloud structures are more likely to be associated with extreme rain than others. In the end, this information could help to associate scale changes in cloud top temperatures with processes that affect the probability of extreme rain. We use 2D continuous wavelets to decompose cloud top temperatures into power spectra at scales between 15 and 200km. From these, cloud sub-structures are identified as circular areas of respective scale with local power maxima in their centre. These areas are then mapped onto coinciding TRMM rainfall, allowing us to assign rainfall fields to sub-cloud features of different scales. We find a higher probability for extreme rainfall for cloud features above a scale of 30km, with features 100km contributing most to the number of extreme rainfall pixels. Over the average diurnal cycle, the number of smaller cloud features between 15-60km shows an increase between 15 - 1700UTC, gradually developing into larger ones. The maximum of extreme rainfall pixels around 1900UTC coincides with a peak for scales 100km, suggesting a dominant role of these scales for intense rain for the analysed cloud type. Our results demonstrate the suitability of 2D wavelet decomposition for the analysis of sub-cloud structures and their relation to rainfall characteristics, and help us to understand long-term changes in the properties of MCS.

Managing System of Systems Requirements with a Requirements Screening Group

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ronald R. Barden

2012-07-01

Figuring out an effective and efficient way to manage not only your Requirement’s Baseline, but also the development of all your individual requirements during a Program’s/Project’s Conceptual and Development Life Cycle Stages can be both daunting and difficult. This is especially so when you are dealing with a complex and large System of Systems (SoS) Program with potentially thousands and thousands of Top Level Requirements as well as an equal number of lower level System, Subsystem and Configuration Item requirements that need to be managed. This task is made even more overwhelming when you have to add in integration withmore » multiple requirements’ development teams (e.g., Integrated Product Development Teams (IPTs)) and/or numerous System/Subsystem Design Teams. One solution for tackling this difficult activity on a recent large System of Systems Program was to develop and make use of a Requirements Screening Group (RSG). This group is essentially a Team made up of co-chairs from the various Stakeholders with an interest in the Program of record that are enabled and accountable for Requirements Development on the Program/Project. The RSG co-chairs, often with the help of individual support team, work together as a Program Board to monitor, make decisions on, and provide guidance on all Requirements Development activities during the Conceptual and Development Life Cycle Stages of a Program/Project. In addition, the RSG can establish and maintain the Requirements Baseline, monitor and enforce requirements traceability across the entire Program, and work with other elements of the Program/Project to ensure integration and coordination.« less

Microphysical effects determine macrophysical response for aerosol impacts on deep convective clouds

PubMed Central

Fan, Jiwen; Leung, L. Ruby; Rosenfeld, Daniel; Chen, Qian; Li, Zhanqing; Zhang, Jinqiang; Yan, Hongru

2013-01-01

Deep convective clouds (DCCs) play a crucial role in the general circulation, energy, and hydrological cycle of our climate system. Aerosol particles can influence DCCs by altering cloud properties, precipitation regimes, and radiation balance. Previous studies reported both invigoration and suppression of DCCs by aerosols, but few were concerned with the whole life cycle of DCC. By conducting multiple monthlong cloud-resolving simulations with spectral-bin cloud microphysics that capture the observed macrophysical and microphysical properties of summer convective clouds and precipitation in the tropics and midlatitudes, this study provides a comprehensive view of how aerosols affect cloud cover, cloud top height, and radiative forcing. We found that although the widely accepted theory of DCC invigoration due to aerosol’s thermodynamic effect (additional latent heat release from freezing of greater amount of cloud water) may work during the growing stage, it is microphysical effect influenced by aerosols that drives the dramatic increase in cloud cover, cloud top height, and cloud thickness at the mature and dissipation stages by inducing larger amounts of smaller but longer-lasting ice particles in the stratiform/anvils of DCCs, even when thermodynamic invigoration of convection is absent. The thermodynamic invigoration effect contributes up to ∼27% of total increase in cloud cover. The overall aerosol indirect effect is an atmospheric radiative warming (3–5 W⋅m−2) and a surface cooling (−5 to −8 W⋅m−2). The modeling findings are confirmed by the analyses of ample measurements made at three sites of distinctly different environments. PMID:24218569

Silicon algae with carbon topping as thin-film anodes for lithium-ion microbatteries by a two-step facile method

NASA Astrophysics Data System (ADS)

Biserni, E.; Xie, M.; Brescia, R.; Scarpellini, A.; Hashempour, M.; Movahed, P.; George, S. M.; Bestetti, M.; Li Bassi, A.; Bruno, P.

2015-01-01

Silicon-based electrodes for Li-ion batteries (LIB) attract much attention because of their high theoretical capacity. However, their large volume change during lithiation results in poor cycling due to mechanical cracking. Moreover, silicon can hardly form a stable solid electrolyte interphase (SEI) layer with common electrolytes. We present a safe, innovative strategy to prepare nanostructured silicon-carbon anodes in a two-step process. The nanoporosity of Si films accommodates the volume expansion while a disordered graphitic C layer on top promotes the formation of a stable SEI. This approach shows its promises: carbon-coated porous silicon anodes perform in a very stable way, reaching the areal capacity of ∼175 μAh cm-2, and showing no decay for at least 1000 cycles. With requiring only a two-step deposition process at moderate temperatures, this novel very simple cell concept introduces a promising way to possibly viable up-scaled production of next-generation nanostructured Si anodes for lithium-ion microbatteries.

The life cycle of a tornadic cloud as seen from a geosynchronous satellite

NASA Technical Reports Server (NTRS)

Hung, R. J.; Dodge, J. C.; Smith, R. E.

1983-01-01

The life span of a severe storm is on the order of a few hours. Rapid-scan infrared and visible observations from geosynchronous satellites can be useful for studying the life cycle of a severe convective storm. By using artificial colors for pixels representing blackbody temperatures of the cloud top, convective storms can be observed throughout their life cycles. In this paper clouds associated with a tornadic storm, the Ringwood, OK tornado on May 29, 1977, are compared with those without a tornadic storm to illustrate how the infrared and visible observations from a geosynchronous satellite can be used to study the differences in their life cycles. The instability of the air mass and the meteorological background are discussed based on balloon observations.

SU-E-T-266: Development of Evaluation System of Optimal Synchrotron Controlling Parameter for Spot Scanning Proton Therapy with Multiple Gate Irradiations in One Operation Cycle

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yamada, T; Fujii, Y; Hitachi Ltd., Hitachi-shi, Ibaraki

2015-06-15

Purpose: We have developed a gated spot scanning proton beam therapy system with real-time tumor-tracking. This system has the ability of multiple-gated irradiation in a single synchrotron operation cycle controlling the wait-time for consecutive gate signals during a flat-top phase so that the decrease in irradiation efficiency induced by irregular variation of gate signal is reduced. Our previous studies have shown that a 200 ms wait-time is appropriate to increase the average irradiation efficiency, but the optimal wait-time can vary patient by patient and day by day. In this research, we have developed an evaluation system of the optimal wait-timemore » in each irradiation based on the log data of the real-time-image gated proton beam therapy (RGPT) system. Methods: The developed system consists of logger for operation of RGPT system and software for evaluation of optimal wait-time. The logger records timing of gate on/off, timing and the dose of delivered beam spots, beam energy and timing of X-ray irradiation. The evaluation software calculates irradiation time in the case of different wait-time by simulating the multiple-gated irradiation operation using several timing information. Actual data preserved in the log data are used for gate on and off time, spot irradiation time, and time moving to the next spot. Design values are used for the acceleration and deceleration times. We applied this system to a patient treated with the RGPT system. Results: The evaluation system found the optimal wait-time of 390 ms that reduced the irradiation time by about 10 %. The irradiation time with actual wait-time used in treatment was reproduced with accuracy of 0.2 ms. Conclusion: For spot scanning proton therapy system with multiple-gated irradiation in one synchrotron operation cycle, an evaluation system of the optimal wait-time in each irradiation based on log data has been developed. Funding Support: Japan Society for the Promotion of Science (JSPS) through the FIRST Program.« less

Relationship among soil surface properties, hydrology and nitrogen cycling along a climatological gradient in drylands

NASA Astrophysics Data System (ADS)

Zaady, E.; Segoli, M.; Eldridge, D. J.; Groffman, P. M.; Boeken, B.; Shachak, M.

2009-04-01

Primary production and nutrient cycling in dryland systems are limited by water supply. There are two groups of primary producers, high biomass production plants and low biomass producing organisms found in biological soil crusts (BSC's), which control energy flow, nutrient cycling and hydrology. Biological or biogenic soil crusts are common in the world's drylands, from dry sub-humid to hyper-arid systems. The crusts are formed by communities of microphytes, mainly cyanobacteria, green algae, mosses, and lichens. The extracellular polysaccharide materials produced by the crust organisms attach soil particles, creating a solid horizontal layer of crust. Biological soil crusts modify soil quality by (1) aggregating soil particles, thereby reducing wind and water erosion; (2) reducing water infiltration, causing overland water run-off; and (3) N fixation and C sequestration. Dryland landscapes are two phase mosaic composed of BSC and high production patches. Development or loss of BSC may trigger changes in the spatial distribution of the patch types and therefore transitions between functional and degraded ecosystem states. We present a conceptual model depicting the function of each patch type and the link between them. Taking into account the contrast between low and high vegetation cover of dryland systems and their role in controlling soil nitrogen and water flows. The model describes the functioning of dryland systems with low biomass producing crust organisms cover, low rainfall, low top soil water and production, which cause low infiltration rate, low N uptake, nitrate accumulation, high evaporation and runoff. This leads to leaching of nitrates, oxygen depletion with high anaerobic conditions, high denitrification rates and N loss, resulting in low plant cover and soil organic matter i.e., degraded soil. It also depicts the functioning of the high production plants under low rainfall regimes resulting in low rates of N and energy flows. The model shows that when the two patches are combined into a source-sink system there is a synergetic effect increasing productivity and diversity, and N cycling and hydrology. The strength of the synergism depends on the climatological gradient. Correspondence to: Eli Zaady (Email: zaadye@volcani.agri.gov.il).

[Effect of spermatozoa from different sources on normal fertilization of oocytes and embryo quality and development in intracytoplasmic sperm injection cycles].

PubMed

Xie, Duo; Qiu, Zhuolin; Luo, Chen; Chu, Qingjun; Quan, Song

2014-06-01

To evaluate the impact of spermatozoa from different sources on normal fertilization of oocytes, embryo quality and embryo developmental potential in intracytoplasmic sperm injection (ICSI) cycles. A retrospective analysis was conducted among 197 patients undergoing ICSI cycles in our center. The patients were classified into 3 groups according to the sources of semen, namely ejaculated spermatozoa group (n=102), percutaneous epididymal sperm aspiration (PESA) group (n=68), and testicular sperm aspiration (TESA) group (n=27). The ejaculated spermatozoa group was further classified into oligoasthenoteratozoospermia (n=67) and cryptozoospermia (n=35) subgroups. The normal fertilization, high-quality embryo, implantation and clinical pregnancy rates were compared among the groups; the rate of high-quality blastocyst formation in in-vitro culture of non-top quality embryos was also observed. The patients with PESA showed significantly higher normal fertilization rate (75.6%) than those in oligoasthenoteratozoospermia (64.8%), cryptozoospermia (62.1%), and TESA (61.6%) groups (P<0.05). No significant differences were found in the high-quality embryo, implantation, and clinical pregnancy rates among the groups (P>0.05). The rate of high-quality blastocyst formation in the in-vitro culture of non-top quality embryos was also comparable among the groups (P>0.05). Although spermatozoa obtained with by PESA is associated with a higher normal fertilization rate, the sources of spermatozoa do not significantly affect the embryonic quality and developmental potential in ICSI cycles.

A Modified Through-Flow Wave Rotor Cycle with Combustor Bypass Ducts

NASA Technical Reports Server (NTRS)

Paxson Daniel E.; Nalim, M. Razi

1998-01-01

A wave rotor cycle is described which avoids the inherent problem of combustor exhaust gas recirculation (EGR) found in four-port, through-flow wave rotor cycles currently under consideration for topping gas turbine engines. The recirculated hot gas is eliminated by the judicious placement of a bypass duct which transfers gas from one end of the rotor to the other. The resulting cycle, when analyzed numerically, yields an absolute mean rotor temperature 18% below the already impressive value of the conventional four-port cycle (approximately the turbine inlet temperature). The absolute temperature of the gas leading to the combustor is also reduced from the conventional four-port design by 22%. The overall design point pressure ratio of this new bypass cycle is approximately the same as the conventional four-port cycle. This paper will describe the EGR problem and the bypass cycle solution including relevant wave diagrams. Performance estimates of design and off-design operation of a specific wave rotor will be presented. The results were obtained using a one-dimensional numerical simulation and design code.

Compact, ultra-low vibration, closed-cycle helium recycler for uninterrupted operation of MEG with SQUID magnetometers

NASA Astrophysics Data System (ADS)

Wang, Chao; Sun, Limin; Lichtenwalter, Ben; Zerkle, Brent; Okada, Yoshio

2016-06-01

A closed-cycle helium recycler was developed for continuous uninterrupted operation for magnetometer-based whole-head magnetoencephalography (MEG) systems. The recycler consists of a two stage 4 K pulse-tube cryocooler and is mounted on the roof of a magnetically shielded room (MSR). A flexible liquid helium (LHe) return line on the recycler is inserted into the fill port of the MEG system in the MSR through a slotted opening in the ceiling. The helium vapor is captured through a line that returns the gas to the top of the recycler assembly. A high-purity helium gas cylinder connected to the recycler assembly supplies the gas, which, after it is liquefied, increases the level of LHe in the MEG system during the start-up phase. No storage tank for evaporated helium gas nor a helium gas purifier is used. The recycler is capable of liquefying helium with a rate of ∼17 L/d after precooling the MEG system. It has provided a fully maintenance-free operation under computer control for 7 months without refill of helium. Although the recycler is used for single-orientation operation at this initial testing site, it is designed to operate at ±20° orientations, allowing the MEG system to be tilted for supine and reclining positions. Vibration of the recycler is dampened to an ultra-low level by using several vibration isolation methods, which enables uninterrupted operation during MEG measurements. Recyclers similar to this system may be quite useful even for MEG systems with 100% magnetometers.

Studying Microbial Mat Functioning Amidst "Unexpected Diversity": Methodological Approaches and Initial Results from Metatranscriptomes of Mats Over Diel cycles, iTags from Long Term Manipulations, and Biogeochemical Cycling in Simplified Microbial Mats Constructed from Cultures

NASA Astrophysics Data System (ADS)

Bebout, B.; Bebout, L. E.; Detweiler, A. M.; Everroad, R. C.; Lee, J.; Pett-Ridge, J.; Weber, P. K.

2014-12-01

Microbial mats are famously amongst the most diverse microbial ecosystems on Earth, inhabiting some of the most inclement environments known, including hypersaline, dry, hot, cold, nutrient poor, and high UV environments. The high microbial diversity of microbial mats makes studies of microbial ecology notably difficult. To address this challenge, we have been using a combination of metagenomics, metatranscriptomics, iTags and culture-based simplified microbial mats to study biogeochemical cycling (H2 production, N2 fixation, and fermentation) in microbial mats collected from Elkhorn Slough, Monterey Bay, California. Metatranscriptomes of microbial mats incubated over a diel cycle have revealed that a number of gene systems activate only during the day in Cyanobacteria, while the remaining appear to be constitutive. The dominant cyanobacterium in the mat (Microcoleus chthonoplastes) expresses several pathways for nitrogen scavenging undocumented in cultured strains, as well as the expression of two starch storage and utilization cycles. Community composition shifts in response to long term manipulations of mats were assessed using iTags. Changes in community diversity were observed as hydrogen fluxes increased in response to a lowering of sulfate concentrations. To produce simplified microbial mats, we have isolated members of 13 of the 15 top taxa from our iTag libraries into culture. Simplified microbial mats and simple co-cultures and consortia constructed from these isolates reproduce many of the natural patterns of biogeochemical cycling in the parent natural microbial mats, but against a background of far lower overall diversity, simplifying studies of changes in gene expression (over the short term), interactions between community members, and community composition changes (over the longer term), in response to environmental forcing.

Beam-based compensation of extracted-beam displacement caused by field ringing of pulsed kicker magnets in the 3 GeV rapid cycling synchrotron of the Japan Proton Accelerator Research Complex

NASA Astrophysics Data System (ADS)

Harada, Hiroyuki; Saha, Pranab Kumar; Tamura, Fumihiko; Meigo, Shin-ichiro; Hotchi, Hideaki; Hayashi, Naoki; Kinsho, Michikazu; Hasegawa, Kazuo

2017-09-01

Commissioned in October 2007, the 3 GeV rapid cycling synchrotron (RCS) of the Japan Proton Accelerator Research Complex was designed for a high-intensity output beam power of 1 MW. The RCS extracts 3 GeV proton beams of two bunches by using eight pulsed kicker magnets and three DC septum magnets with 25 Hz repetition. These beams are delivered to a materials and life science experimental facility (MLF) and a 50 GeV main ring synchrotron (MR). However, the flat-top fields of the kicker magnets experience ringing that displaces the position of the extracted beam. This displacement is a major issue from the viewpoint of target integrity at the MLF and emittance growth at MR injection. To understand the flat-top uniformity of the total field of all the kickers, the uniformity was measured as the displacement of the extracted beams by using a shorter bunched beam and scanning the entire trigger timing of the kickers. The beam displacement of the first bunch exceeded the required range. Therefore, we performed beam-based measurements kicker by kicker to understand each field-ringing effect, and then we understood the characteristics (strength and temporal structure) of each ringing field. We managed to cancel out the ringing by using all the beam-based measurement data and optimizing each trigger timing. As a result, the field-ringing effect of the kickers was successfully compensated by optimizing the trigger timing of each kicker without hardware upgrades or improvements to the kicker system. By developing an automatic monitoring and correction system, we now have a higher stability of extracted beams during routine user operation. In this paper, we report our procedure for ringing compensation and present supporting experimental results.

Imaging Seismic Source Variations Using Back-Projection Methods at El Tatio Geyser Field, Northern Chile

NASA Astrophysics Data System (ADS)

Kelly, C. L.; Lawrence, J. F.

2014-12-01

During October 2012, 51 geophones and 6 broadband seismometers were deployed in an ~50x50m region surrounding a periodically erupting columnar geyser in the El Tatio Geyser Field, Chile. The dense array served as the seismic framework for a collaborative project to study the mechanics of complex hydrothermal systems. Contemporaneously, complementary geophysical measurements (including down-hole temperature and pressure, discharge rates, thermal imaging, water chemistry, and video) were also collected. Located on the western flanks of the Andes Mountains at an elevation of 4200m, El Tatio is the third largest geyser field in the world. Its non-pristine condition makes it an ideal location to perform minutely invasive geophysical studies. The El Jefe Geyser was chosen for its easily accessible conduit and extremely periodic eruption cycle (~120s). During approximately 2 weeks of continuous recording, we recorded ~2500 nighttime eruptions which lack cultural noise from tourism. With ample data, we aim to study how the source varies spatially and temporally during each phase of the geyser's eruption cycle. We are developing a new back-projection processing technique to improve source imaging for diffuse signals. Our method was previously applied to the Sierra Negra Volcano system, which also exhibits repeating harmonic and diffuse seismic sources. We back-project correlated seismic signals from the receivers back to their sources, assuming linear source to receiver paths and a known velocity model (obtained from ambient noise tomography). We apply polarization filters to isolate individual and concurrent geyser energy associated with P and S phases. We generate 4D, time-lapsed images of the geyser source field that illustrate how the source distribution changes through the eruption cycle. We compare images for pre-eruption, co-eruption, post-eruption and quiescent periods. We use our images to assess eruption mechanics in the system (i.e. top-down vs. bottom-up) and determine variations in source depth and distribution in the conduit and larger geyser field over many eruption cycles.

Sex hormones affect language lateralisation but not cognitive control in normally cycling women.

PubMed

Hodgetts, Sophie; Weis, Susanne; Hausmann, Markus

2015-08-01

This article is part of a Special Issue "Estradiol and Cognition". Natural fluctuations of sex hormones during the menstrual cycle have been shown to modulate language lateralisation. Using the dichotic listening (DL) paradigm, a well-established measurement of language lateralisation, several studies revealed that the left hemispheric language dominance was stronger when levels of estradiol were high. A recent study (Hjelmervik et al., 2012) showed, however, that high levels of follicular estradiol increased lateralisation only in a condition that required participants to cognitively control (top-down) the stimulus-driven (bottom-up) response. This finding suggested that sex hormones modulate lateralisation only if cognitive control demands are high. The present study investigated language lateralisation in 73 normally cycling women under three attention conditions that differed in cognitive control demands. Saliva estradiol and progesterone levels were determined by luminescence immunoassays. Women were allocated to a high or low estradiol group. The results showed a reduced language lateralisation when estradiol and progesterone levels were high. The effect was independent of the attention condition indicating that estradiol marginally affected cognitive control. The findings might suggest that high levels of estradiol especially reduce the stimulus-driven (bottom-up) aspect of lateralisation rather than top-down cognitive control. Copyright © 2015 Elsevier Inc. All rights reserved.

Frequency modulation of neural oscillations according to visual task demands.

PubMed

Wutz, Andreas; Melcher, David; Samaha, Jason

2018-02-06

Temporal integration in visual perception is thought to occur within cycles of occipital alpha-band (8-12 Hz) oscillations. Successive stimuli may be integrated when they fall within the same alpha cycle and segregated for different alpha cycles. Consequently, the speed of alpha oscillations correlates with the temporal resolution of perception, such that lower alpha frequencies provide longer time windows for perceptual integration and higher alpha frequencies correspond to faster sampling and segregation. Can the brain's rhythmic activity be dynamically controlled to adjust its processing speed according to different visual task demands? We recorded magnetoencephalography (MEG) while participants switched between task instructions for temporal integration and segregation, holding stimuli and task difficulty constant. We found that the peak frequency of alpha oscillations decreased when visual task demands required temporal integration compared with segregation. Alpha frequency was strategically modulated immediately before and during stimulus processing, suggesting a preparatory top-down source of modulation. Its neural generators were located in occipital and inferotemporal cortex. The frequency modulation was specific to alpha oscillations and did not occur in the delta (1-3 Hz), theta (3-7 Hz), beta (15-30 Hz), or gamma (30-50 Hz) frequency range. These results show that alpha frequency is under top-down control to increase or decrease the temporal resolution of visual perception.

Stratigraphy and depositional history of the West Franklin Limestone (Pennsylvanian) in the southernmost part of the Illinois Basin, western Kentucky

DOE Office of Scientific and Technical Information (OSTI.GOV)

King, N.R.

1994-04-01

The West Franklin Limestone in the subsurface of Webster and Union Counties, Kentucky includes 7.5--18m of strata deposited during portions of four depositional cycles in the latest Desmoinesian and earliest Missourian (Pennsylvanian). These cycles began with marine flooding and deposition of limestone, followed by progradation of siliciclastics in three of the four cycles, and ended with emergence. The basal West Franklin is micritic limestone (0.5--3m) that rests on rooted mudstone. Overlying the limestone are siliciclastics (1.5--7m) dominated by red and green claystone that is rooted at the top. Next is a middle limestone zone that includes either a paleokarsted micriticmore » limestone, or a thin bioclastic micritic limestone bed associated with phosphatic shale and locally a second bioclastic micritic limestone. Above that is another siliciclastic interval (4--9m) capped by rooted mudstone and locally a thin coal. The overlying micritic limestone (1.5--2.5m) marks the top of the West Franklin. Depositional events included: (1) marine flooding of an emergent shelf producing the basal limestone; (2) progradation of siliciclastics followed by emergence and paleosol development; (3) marine flooding producing a second limestone; (4) emergence and karstification of erosional remnants of the second limestone; (5) renewed marine flooding depositing shell hash'' limestones and phosphatic shale; (6) progradation of siliciclastics culminating in emergency; and (7) marine flooding producing the upper limestone. Thus, two flooding-emergence cycles are represented by the middle limestone zone. The second, locally-developed shell-hash'' limestone in the middle zone was deposited during the regressive phase of a depositional cycle. All of the other limestones were deposited during transgression.« less

40 CFR 97.602 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... trimmings. Boiler means an enclosed fossil- or other-fuel-fired combustion device used to produce heat and... electricity through the sequential use of energy. Cogeneration unit means a stationary, fossil-fuel-fired boiler or stationary, fossil-fuel-fired combustion turbine that is a topping-cycle unit or a bottoming...

40 CFR 97.702 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... trimmings. Boiler means an enclosed fossil- or other-fuel-fired combustion device used to produce heat and... electricity through the sequential use of energy. Cogeneration unit means a stationary, fossil-fuel-fired boiler or stationary, fossil-fuel-fired combustion turbine that is a topping-cycle unit or a bottoming...

40 CFR 97.702 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... trimmings. Boiler means an enclosed fossil- or other-fuel-fired combustion device used to produce heat and... electricity through the sequential use of energy. Cogeneration unit means a stationary, fossil-fuel-fired boiler or stationary, fossil-fuel-fired combustion turbine that is a topping-cycle unit or a bottoming...

40 CFR 97.602 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... trimmings. Boiler means an enclosed fossil- or other-fuel-fired combustion device used to produce heat and... electricity through the sequential use of energy. Cogeneration unit means a stationary, fossil-fuel-fired boiler or stationary, fossil-fuel-fired combustion turbine that is a topping-cycle unit or a bottoming...

40 CFR 97.602 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... trimmings. Boiler means an enclosed fossil- or other-fuel-fired combustion device used to produce heat and... electricity through the sequential use of energy. Cogeneration unit means a stationary, fossil-fuel-fired boiler or stationary, fossil-fuel-fired combustion turbine that is a topping-cycle unit or a bottoming...

40 CFR 97.702 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... trimmings. Boiler means an enclosed fossil- or other-fuel-fired combustion device used to produce heat and... electricity through the sequential use of energy. Cogeneration unit means a stationary, fossil-fuel-fired boiler or stationary, fossil-fuel-fired combustion turbine that is a topping-cycle unit or a bottoming...

EVOLUTION OF THE NOCTURNAL INVERSION LAYER AT AN URBAN AND NONURBAN LOCATION

EPA Science Inventory

The evolutionary cycle of the nocturnal radiation inversion layer from formation until dissipation under fair weather conditions was investigated by time-series analyses of observations of inversion base and top heights, and inversion strength at an urban and a nonurban site in S...

Feasibility Study of Supercritical Light Water Cooled Reactors for Electric Power Production, Nuclear Energy Research Initiative Project 2001-001, Westinghouse Electric Co. Grant Number: DE-FG07-02SF22533, Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Philip E. MacDonald

2005-01-01

The supercritical water-cooled reactor (SCWR) is one of the six reactor technologies selected for research and development under the Generation IV program. SCWRs are promising advanced nuclear systems because of their high thermal efficiency (i.e., about 45% versus about 33% efficiency for current Light Water Reactors [LWRs]) and considerable plant simplification. SCWRs are basically LWRs operating at higher pressure and temperatures with a direct once-through cycle. Operation above the critical pressure eliminates coolant boiling, so the coolant remains single-phase throughout the system. Thus, the need for a pressurizer, steam generators, steam separators, and dryers is eliminated. The main mission ofmore » the SCWR is generation of low-cost electricity. It is built upon two proven technologies: LWRs, which are the most commonly deployed power generating reactors in the world, and supercritical fossil-fired boilers, a large number of which are also in use around the world. The reference SCWR design for the U.S. program is a direct cycle system operating at 25.0 MPa, with core inlet and outlet temperatures of 280 and 500 C, respectively. The coolant density decreases from about 760 kg/m3 at the core inlet to about 90 kg/m3 at the core outlet. The inlet flow splits with about 10% of the inlet flow going down the space between the core barrel and the reactor pressure vessel (the downcomer) and about 90% of the inlet flow going to the plenum at the top of the rector pressure vessel, to then flow down through the core in special water rods to the inlet plenum. Here it mixes with the feedwater from the downcomer and flows upward to remove the heat in the fuel channels. This strategy is employed to provide good moderation at the top of the core. The coolant is heated to about 500 C and delivered to the turbine. The purpose of this NERI project was to assess the reference U.S. Generation IV SCWR design and explore alternatives to determine feasibility. The project was organized into three tasks: Task 1. Fuel-cycle Neutronic Analysis and Reactor Core Design Task 2. Fuel Cladding and Structural Material Corrosion and Stress Corrosion Cracking Task 3. Plant Engineering and Reactor Safety Analysis. moderator rods. materials.« less

Trajectory correction propulsion for TOPS

NASA Technical Reports Server (NTRS)

Long, H. R.; Bjorklund, R. A.

1972-01-01

A blowdown-pressurized hydrazine propulsion system was selected to provide trajectory correction impulse for outer planet flyby spacecraft as the result of cost/mass/reliability tradeoff analyses. Present hydrazine component and system technology and component designs were evaluated for application to the Thermoelectric Outer Planet Spacecraft (TOPS); while general hydrazine technology was adequate, component design changes were deemed necessary for TOPS-type missions. A prototype hydrazine propulsion system was fabricated and fired nine times for a total of 1600 s to demonstrate the operation and performance of the TOPS propulsion configuration. A flight-weight trajectory correction propulsion subsystem (TCPS) was designed for the TOPS based on actual and estimated advanced components.

Error Cost Escalation Through the Project Life Cycle

NASA Technical Reports Server (NTRS)

Stecklein, Jonette M.; Dabney, Jim; Dick, Brandon; Haskins, Bill; Lovell, Randy; Moroney, Gregory

2004-01-01

It is well known that the costs to fix errors increase as the project matures, but how fast do those costs build? A study was performed to determine the relative cost of fixing errors discovered during various phases of a project life cycle. This study used three approaches to determine the relative costs: the bottom-up cost method, the total cost breakdown method, and the top-down hypothetical project method. The approaches and results described in this paper presume development of a hardware/software system having project characteristics similar to those used in the development of a large, complex spacecraft, a military aircraft, or a small communications satellite. The results show the degree to which costs escalate, as errors are discovered and fixed at later and later phases in the project life cycle. If the cost of fixing a requirements error discovered during the requirements phase is defined to be 1 unit, the cost to fix that error if found during the design phase increases to 3 - 8 units; at the manufacturing/build phase, the cost to fix the error is 7 - 16 units; at the integration and test phase, the cost to fix the error becomes 21 - 78 units; and at the operations phase, the cost to fix the requirements error ranged from 29 units to more than 1500 units

A hardware implementation of the discrete Pascal transform for image processing

NASA Astrophysics Data System (ADS)

Goodman, Thomas J.; Aburdene, Maurice F.

2006-02-01

The discrete Pascal transform is a polynomial transform with applications in pattern recognition, digital filtering, and digital image processing. It already has been shown that the Pascal transform matrix can be decomposed into a product of binary matrices. Such a factorization leads to a fast and efficient hardware implementation without the use of multipliers, which consume large amounts of hardware. We recently developed a field-programmable gate array (FPGA) implementation to compute the Pascal transform. Our goal was to demonstrate the computational efficiency of the transform while keeping hardware requirements at a minimum. Images are uploaded into memory from a remote computer prior to processing, and the transform coefficients can be offloaded from the FPGA board for analysis. Design techniques like as-soon-as-possible scheduling and adder sharing allowed us to develop a fast and efficient system. An eight-point, one-dimensional transform completes in 13 clock cycles and requires only four adders. An 8x8 two-dimensional transform completes in 240 cycles and requires only a top-level controller in addition to the one-dimensional transform hardware. Finally, through minor modifications to the controller, the transform operations can be pipelined to achieve 100% utilization of the four adders, allowing one eight-point transform to complete every seven clock cycles.

Unexpected dominance of parent-material strontium in a tropical forest on highly weathered soils

USGS Publications Warehouse

Bern, C.R.; Townsend, A.R.; Farmer, G.L.

2005-01-01

Controls over nutrient supply are key to understanding the structure and functioning of terrestrial ecosystems. Conceptual models once held that in situ mineral weathering was the primary long-term control over the availability of many plant nutrients, including the base cations calcium (Ca), magnesium (Mg), and potassium (K). Recent evidence has shown that atmospheric sources of these "rock-derived" nutrients can dominate actively cycling ecosystem pools, especially in systems on highly weathered soils. Such studies have relied heavily on the use of strontium isotopes as a proxy for base-cation cycling. Here we show that vegetation and soil-exchangeable pools of strontium in a tropical rainforest on highly weathered soils are still dominated by local rock sources. This pattern exists despite substantial atmospheric inputs of Sr, Ca, K, and Mg, and despite nearly 100% depletion of these elements from the top 1 m of soil. We present a model demonstrating that modest weathering inputs, resulting from tectonically driven erosion, could maintain parent-material dominance of actively cycling Sr. The majority of tropical forests are on highly weathered soils, but our results suggest that these forests may still show considerable variation in their primary sources of essential nutrients. ?? 2005 by the Ecological Society of America.

Coupling Computer-Aided Process Simulation and ...

EPA Pesticide Factsheets

A methodology is described for developing a gate-to-gate life cycle inventory (LCI) of a chemical manufacturing process to support the application of life cycle assessment in the design and regulation of sustainable chemicals. The inventories were derived by first applying process design and simulation of develop a process flow diagram describing the energy and basic material flows of the system. Additional techniques developed by the U.S. Environmental Protection Agency for estimating uncontrolled emissions from chemical processing equipment were then applied to obtain a detailed emission profile for the process. Finally, land use for the process was estimated using a simple sizing model. The methodology was applied to a case study of acetic acid production based on the Cativa tm process. The results reveal improvements in the qualitative LCI for acetic acid production compared to commonly used databases and top-down methodologies. The modeling techniques improve the quantitative LCI results for inputs and uncontrolled emissions. With provisions for applying appropriate emission controls, the proposed method can provide an estimate of the LCI that can be used for subsequent life cycle assessments. As part of its mission, the Agency is tasked with overseeing the use of chemicals in commerce. This can include consideration of a chemical's potential impact on health and safety, resource conservation, clean air and climate change, clean water, and sustainable

Device for thermal transfer and power generation

DOEpatents

Weaver, Stanton Earl [Northville, NY; Arik, Mehmet [Niskayuna, NY

2011-04-19

A system is provided. The system includes a device that includes top and bottom thermally conductive substrates positioned opposite to one another, wherein a top surface of the bottom thermally conductive substrate is substantially atomically flat and a thermal blocking layer disposed between the top and bottom thermally conductive substrates. The device also includes top and bottom electrodes separated from one another between the top and bottom thermally conductive substrates to define a tunneling path, wherein the top electrode is disposed on the thermal blocking layer and the bottom electrode is disposed on the bottom thermally conductive substrate.

Top-down control of methane emission and nitrogen cycling by waterfowl.

PubMed

Winton, R Scott; Richardson, Curtis J

2017-01-01

Aquatic herbivores impose top-down control on the structure of wetland ecosystems, but the biogeochemical consequences of herbivory on methane (CH 4 ) and nitrogen (N) are poorly known. To investigate the top-down effects of waterfowl on wetland biogeochemistry, we implemented exclosure experiments in a major waterfowl overwintering wetland in the southeastern United States over two growing seasons. We found that herbivory inhibited the oxidation of CH 4 , leading to a mean increase in emission by 230% over control plots, and prevented nitrification, as indicated by low nitrate availability and undetectable emissions of nitrous oxide. Herbivory reduced belowground biomass of macrophytes, retarding the subsequent spring emergence of aerenchymous stems, effectively starving wetland soils of oxygen necessary for CH 4 oxidation and nitrification. The recognition that important populations of aquatic herbivores may influence the capacity for wetlands to emit greenhouse gases and cycle N is particularly salient in the context of climate change and nutrient pollution mitigation goals. For example, our results suggest that (1) annual emissions of 23 Gg CH 4 /yr from ~57 000 ha of publicly owned waterfowl impoundments in the southeastern United States could be tripled by overgrazing and that (2) waterfowl impoundments may export as much N as agricultural fields. We discuss potential implications for habitat management in the context of historic wetland loss and waterfowl population recovery. © 2016 by the Ecological Society of America.

Dynamic hybrid life cycle assessment of energy and carbon of multicrystalline silicon photovoltaic systems.

PubMed

Zhai, Pei; Williams, Eric D

2010-10-15

This paper advances the life cycle assessment (LCA) of photovoltaic systems by expanding the boundary of the included processes using hybrid LCA and accounting for the technology-driven dynamics of embodied energy and carbon emissions. Hybrid LCA is an extended method that combines bottom-up process-sum and top-down economic input-output (EIO) methods. In 2007, the embodied energy was 4354 MJ/m(2) and the energy payback time (EPBT) was 2.2 years for a multicrystalline silicon PV system under 1700 kWh/m(2)/yr of solar radiation. These results are higher than those of process-sum LCA by approximately 60%, indicating that processes excluded in process-sum LCA, such as transportation, are significant. Even though PV is a low-carbon technology, the difference between hybrid and process-sum results for 10% penetration of PV in the U.S. electrical grid is 0.13% of total current grid emissions. Extending LCA from the process-sum to hybrid analysis makes a significant difference. Dynamics are characterized through a retrospective analysis and future outlook for PV manufacturing from 2001 to 2011. During this decade, the embodied carbon fell substantially, from 60 g CO(2)/kWh in 2001 to 21 g/kWh in 2011, indicating that technological progress is realizing reductions in embodied environmental impacts as well as lower module price.

Debugging expert systems using a dynamically created hypertext network

NASA Technical Reports Server (NTRS)

Boyle, Craig D. B.; Schuette, John F.

1991-01-01

The labor intensive nature of expert system writing and debugging motivated this study. The hypothesis is that a hypertext based debugging tool is easier and faster than one traditional tool, the graphical execution trace. HESDE (Hypertext Expert System Debugging Environment) uses Hypertext nodes and links to represent the objects and their relationships created during the execution of a rule based expert system. HESDE operates transparently on top of the CLIPS (C Language Integrated Production System) rule based system environment and is used during the knowledge base debugging process. During the execution process HESDE builds an execution trace. Use of facts, rules, and their values are automatically stored in a Hypertext network for each execution cycle. After the execution process, the knowledge engineer may access the Hypertext network and browse the network created. The network may be viewed in terms of rules, facts, and values. An experiment was conducted to compare HESDE with a graphical debugging environment. Subjects were given representative tasks. For speed and accuracy, in eight of the eleven tasks given to subjects, HESDE was significantly better.

Hydrologic influence on redox dynamics in estuarine environments

NASA Astrophysics Data System (ADS)

Michael, H. A.; Kim, K. H.; Guimond, J. A.; Heiss, J.; Ullman, W. J.; Seyfferth, A.

2017-12-01

Redox conditions in coastal aquifers control reactions that impact nutrient cycling, contaminant release, and carbon budgets, with implications for water resources and ecosystem health. Hydrologic changes can shift redox boundaries and inputs of reactants, especially in dynamic coastal systems subject to fluctuations on tidal, lunar, and longer timescales. We present two examples of redox shifts in estuarine systems in Delaware, USA: a beach aquifer and a saltmarsh. Beach aquifers are biogeochemical hot spots due to mixing between fresh groundwater and infiltrating seawater. At Cape Henlopen, DE, geochemical measurements identified reactions in the intertidal aquifer that include cycling of carbon, nitrogen, iron, and sulfur. Measurements and modeling illustrate that redox potential as well as the locations of redox reactions shift on tidal to seasonal timescales and in response to changing beach and aquifer properties, impacting overall rates of reactions such as denitrification that reduces N loads to coastal waters. In the St. Jones National Estuarine Research Reserve, tidal fluctuations in channels cause periodic groundwater-surface water exchange, water table movement, and intermittent flooding that varies spatially across the saltmarsh. These changes create shifts in redox potential that are greatest near channels and in the top 20 cm of sediments. The magnitude of redox change depends on hydrologic setting (near channels or in marsh interior), hydrologic conditions (tidal stage, seasonal shifts), as well as prevalence of macropores created by crab burrows that change seasonally with crab activity. These shifts correspond to changes in porewater chemistry that have implications for nutrient cycling and carbon export to the ocean. Understanding hydrologic influence on redox geochemistry is critical for predicting how these systems and their ecosystem services may change in the future in response to anthropogenic and climate change.

Mitigating Groundwater Depletion in North China Plain with Cropping System that Alternate Deep and Shallow Rooted Crops

PubMed Central

Yang, Xiao-Lin; Chen, Yuan-Quan; Steenhuis, Tammo S.; Pacenka, Steven; Gao, Wang-Sheng; Ma, Li; Zhang, Min; Sui, Peng

2017-01-01

In the North China Plain, groundwater tables have been dropping at unsustainable rates of 1 m per year due to irrigation of a double cropping system of winter wheat and summer maize. To reverse the trend, we examined whether alternative crop rotations could save water. Moisture contents were measured weekly at 20 cm intervals in the top 180 cm of soil as part of a 12-year field experiment with four crop rotations: sweet potato→ cotton→ sweet potato→ winter wheat-summer maize (SpCSpWS, 4-year cycle); peanuts → winter wheat-summer maize (PWS, 2-year cycle); ryegrass–cotton→ peanuts→ winter wheat-summer maize (RCPWS, 3-year cycle); and winter wheat-summer maize (WS, each year). We found that, compared to WS, the SpCSpWS annual evapotranspiration was 28% lower, PWS was 19% lower and RCPWS was 14% lower. The yield per unit of water evaporated improved for wheat within any alternative rotation compared to WS, increasing up to 19%. Average soil moisture contents at the sowing date of wheat in the SpCSpWS, PWS, and RCPWS rotations were 7, 4, and 10% higher than WS, respectively. The advantage of alternative rotations was that a deep rooted crop of winter wheat reaching down to 180 cm followed shallow rooted crops (sweet potato and peanut drawing soil moisture from 0 to 120 cm). They benefited from the sequencing and vertical complementarity of soil moisture extraction. Thus, replacing the traditional crop rotation with cropping system that involves rotating with annual shallow rooted crops is promising for reducing groundwater depletion in the North China Plain. PMID:28642779

Tropical Cyclone Diurnal Cycle as Observed by TRMM

NASA Technical Reports Server (NTRS)

Leppert, Kenneth D., II; Cecil, D. J.

2015-01-01

Using infrared satellite data, previous work has shown a consistent diurnal cycle in the pattern of cold cloud tops around mature tropical cyclones. In particular, an increase in the coverage by cold cloud tops often occurs in the inner core of the storm around the time of sunset and subsequently propagates outward to several hundred kilometers over the course of the following day. This consistent cycle may have important implications for structure and intensity changes of tropical cyclones and the forecasting of such changes. Because infrared satellite measurements are primarily sensitive to cloud top, the goal of this study is to use passive and active microwave measurements from the Tropical Rainfall Measurement Mission (TRMM) Microwave Imager (TMI) and Precipitation Radar (PR), respectively, to examine and better understand the tropical cyclone diurnal cycle throughout a larger depth of the storm's clouds. The National Hurricane Center's best track dataset was used to extract all PR and TMI pixels within 1000 km of each tropical cyclone that occurred in the Atlantic basin between 1998-2011. Then the data was composited according to radius (100-km bins from 0-1000 km) and local standard time (LST; 3-hr bins). Specifically, PR composites involved finding the percentage of pixels with reflectivity greater than or equal to 20 dBZ at various heights (i.e., 2-14 km in increments of 2 km) as a function of radius and time. The 37- and 85- GHz TMI channels are especially sensitive to scattering by precipitation-sized ice in the mid to upper portions of clouds. Hence, the percentage of 37- and 85-GHz polarization corrected temperatures less than various thresholds were calculated using data from all storms as a function of radius and time. For 37 GHz, thresholds of 260 K, 265 K, 270 K, and 275 K were used, and for 85 GHz, thresholds of 200-270 K in increments of 10 K were utilized. Note that convection forced by the interactions of a tropical cyclone with land (e.g., due to frictional convergence) may disrupt the natural convective cycle of a cyclone. Hence, only data pertaining to storms whose centers were greater than 300 km from land were included in the composites. Early results suggest the presence of a diurnal cycle in the PR composites of all Atlantic basin tropical cyclones from a height of 2-12 km from approximately 0-400 km radius, but the cycle is most apparent above 6 km. At a height of 8 km, there is a peak (minimum) in the percentage of PR pixels greater than or equal to 20 dBZ near 0 (21) LST in the inner core with some indication that this signal propagates outward with time. In contrast, the 37- and 85-GHz composites show little indication of a diurnal cycle at any radii, regardless of the threshold used. Ongoing work with this project will involve sub-setting the composites according to storm intensity to see if the diurnal cycle varies with storm strength. Moderate to strong vertical wind shear often leads to asymmetries in tropical cyclone convection and may disrupt the cyclone's natural diurnal cycle. Therefore, wind shear thresholds will be applied to the composites to determine if the diurnal cycle becomes more apparent in a low shear environment. Finally, other work to be completed will involve developing composites for other tropical cyclone basins, including the East Pacific, Northwest Pacific, South Pacific, and Indian Ocean.

Final Technical Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

de Szoeke, Simon P.

The investigator and DOE-supported student [1] retrieved vertical air velocity and microphysical fall velocity retrieval for VOCALS and CAP-MBL homogeneous clouds. [2] Calculated in-cloud and cloud top dissipation calculation and diurnal cycle computed for VOCALS. [3] Compared CAP-MBL Doppler cloud radar scenes with (Remillard et al. 2012) automated classification.

Top-Down Protein Identification of Proteasome Proteins with nanoLC FT-ICR MS Employing Data-Independent Fragmentation Methods

PubMed Central

Lakshmanan, Rajeswari; Wolff, Jeremy J.; Alvarado, Rudy; Loo, Joseph A.

2014-01-01

A comparison of different data-independent fragmentation methods combined with liquid chromatography (LC) coupled to high resolution Fourier-transform ion cyclotron resonance (FT-ICR) tandem mass spectrometry (MS) is presented for top-down MS of protein mixtures. Proteins composing the 20S and 19S proteasome complex and their post-translational modifications were identified using a 15-Tesla FT-ICR mass spectrometer. The data-independent fragmentation modes with LC timescales allowed for higher duty cycle measurements that better suit on-line LC-FT-ICR-MS. Protein top-down dissociation was effected by funnel-skimmer collisionally activated dissociation (FS-CAD) and CASI (Continuous Accumulation of Selected Ions)-CAD. The N-terminus for 9 out of the 14 20S proteasome proteins were found to be modified, and the α3 protein was found to be phosphorylated; these results are consistent with previous reports. Mass measurement accuracy with the LC-FT-ICR system for the 20–30 kDa 20S proteasome proteins was 1 ppm. The intact mass of the 100 kDa Rpn1 subunit from the 19S proteasome complex regulatory particle was measured with a deviation of 17 ppm. The CASI-CAD technique is a complementary tool for intact protein fragmentation and is an effective addition to the growing inventory of dissociation methods which are compatible with on-line protein separation coupled to FT-ICR MS. PMID:24478249

Utilization of waste materials, non-refined materials, and renewable energy in in situ remediation and their sustainability benefits.

PubMed

Favara, Paul; Gamlin, Jeff

2017-12-15

In the ramp-up to integrating sustainability into remediation, a key industry focus area has been to reduce the environmental footprint of treatment processes. The typical approach to integrating sustainability into remediation projects has been a top-down approach, which involves developing technology options and then applying sustainability thinking to the technology, after it has been conceptualized. A bottom-up approach allows for systems thinking to be included in remedy selection and could potentially result in new or different technologies being considered. When using a bottom-up approach, there is room to consider the utilization of waste materials, non-refined materials, and renewable energy in remediation technology-all of which generally have a smaller footprint than processed materials and traditional forms of energy. By integrating more systems thinking into remediation projects, practitioners can think beyond the traditional technologies typically used and how technologies are deployed. To compare top-down and bottom-up thinking, a traditional technology that is considered very sustainable-enhanced in situ bioremediation-is compared to a successful, but infrequently deployed technology-subgrade biogeochemical reactors. Life Cycle Assessment is used for the evaluation and shows the footprint of the subgrade biogeochemical reactor to be lower in all seven impact categories evaluated, sometimes to a significant degree. Copyright © 2017 Elsevier Ltd. All rights reserved.

Assessing the Importance of Prior Biospheric Fluxes on Inverse Model Estimates of CO2

NASA Astrophysics Data System (ADS)

Philip, S.; Johnson, M. S.; Potter, C. S.; Genovese, V. B.

2017-12-01

Atmospheric mixing ratios of carbon dioxide (CO2) are largely controlled by anthropogenic emissions and biospheric sources/sinks. The processes controlling terrestrial biosphere-atmosphere carbon exchange are currently not fully understood, resulting in models having significant differences in the quantification of biospheric CO2 fluxes. Currently, atmospheric chemical transport models (CTM) and global climate models (GCM) use multiple different biospheric CO2 flux models resulting in large differences in simulating the global carbon cycle. The Orbiting Carbon Observatory 2 (OCO-2) satellite mission was designed to allow for the improved understanding of the processes involved in the exchange of carbon between terrestrial ecosystems and the atmosphere, and therefore allowing for more accurate assessment of the seasonal/inter-annual variability of CO2. OCO-2 provides much-needed CO2 observations in data-limited regions allowing for the evaluation of model simulations of greenhouse gases (GHG) and facilitating global/regional estimates of "top-down" CO2 fluxes. We conduct a 4-D Variation (4D-Var) data assimilation with the GEOS-Chem (Goddard Earth Observation System-Chemistry) CTM using 1) OCO-2 land nadir and land glint retrievals and 2) global in situ surface flask observations to constrain biospheric CO2 fluxes. We apply different state-of-the-science year-specific CO2 flux models (e.g., NASA-CASA (NASA-Carnegie Ames Stanford Approach), CASA-GFED (Global Fire Emissions Database), Simple Biosphere Model version 4 (SiB-4), and LPJ (Lund-Postdam-Jena)) to assess the impact of "a priori" flux predictions to "a posteriori" estimates. We will present the "top-down" CO2 flux estimates for the year 2015 using OCO-2 and in situ observations, and a complete indirect evaluation of the a priori and a posteriori flux estimates using independent in situ observations. We will also present our assessment of the variability of "top-down" CO2 flux estimates when using different biospheric CO2 flux models. This work will improve our understanding of the global carbon cycle, specifically, how OCO-2 observations can be used to constrain biospheric CO2 flux model estimates.

Self-induced redox cycling coupled luminescence on nanopore recessed disk-multiscale bipolar electrodes

DOE PAGES

Ma, Chaoxiong; Zaino III, Lawrence P.; Bohn, Paul W.

2015-03-25

Self-induced redox cycling at nanopore ring-disk electrodes is coupled, through a bipolar electrode, to a remote fluorigenic reporter reaction. We present a new configuration for coupling fluorescence microscopy and voltammetry using self-induced redox cycling for ultrasensitive electrochemical measurements. An array of nanopores, each supporting a recessed disk electrode separated by 100 nm in depth from a planar multiscale bipolar top electrode, was fabricated using multilayer deposition, nanosphere lithography, and reactive-ion etching. Self-induced redox cycling was induced on the disk electrode producing ~30× current amplification, which was independently confirmed by measuring induced electrogenerated chemiluminescence from Ru(bpy) 3 2/3+/tri-n-propylamine on the floatingmore » bipolar electrode. In this design, redox cycling occurs between the recessed disk and the top planar portion of a macroscopic thin film bipolar electrode in each nanopore. Electron transfer also occurs on a remote (mm-distance) portion of the planar bipolar electrode to maintain electroneutrality. This couples the electrochemical reactions of the target redox pair in the nanopore array with a reporter, such as a potential-switchable fluorescent indicator, in the cell at the distal end of the bipolar electrode. Oxidation or reduction of reversible analytes on the disk electrodes were accompanied by reduction or oxidation, respectively, on the nanopore portion of the bipolar electrode and then monitored by the accompanying oxidation of dihydroresorufin or reduction of resorufin at the remote end of the bipolar electrode, respectively. In both cases, changes in fluorescence intensity were triggered by the reaction of the target couple on the disk electrode, while recovery was largely governed by diffusion of the fluorescent indicator. Reduction of 1 nM of Ru(NH 3) 6 3+ on the nanoelectrode array was detected by monitoring the fluorescence intensity of resorufin, demonstrating high sensitivity fluorescence-mediated electrochemical sensing coupled to self-induced redox cycling.« less

Self-induced redox cycling coupled luminescence on nanopore recessed disk-multiscale bipolar electrodes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ma, Chaoxiong; Zaino III, Lawrence P.; Bohn, Paul W.

Self-induced redox cycling at nanopore ring-disk electrodes is coupled, through a bipolar electrode, to a remote fluorigenic reporter reaction. We present a new configuration for coupling fluorescence microscopy and voltammetry using self-induced redox cycling for ultrasensitive electrochemical measurements. An array of nanopores, each supporting a recessed disk electrode separated by 100 nm in depth from a planar multiscale bipolar top electrode, was fabricated using multilayer deposition, nanosphere lithography, and reactive-ion etching. Self-induced redox cycling was induced on the disk electrode producing ~30× current amplification, which was independently confirmed by measuring induced electrogenerated chemiluminescence from Ru(bpy) 3 2/3+/tri-n-propylamine on the floatingmore » bipolar electrode. In this design, redox cycling occurs between the recessed disk and the top planar portion of a macroscopic thin film bipolar electrode in each nanopore. Electron transfer also occurs on a remote (mm-distance) portion of the planar bipolar electrode to maintain electroneutrality. This couples the electrochemical reactions of the target redox pair in the nanopore array with a reporter, such as a potential-switchable fluorescent indicator, in the cell at the distal end of the bipolar electrode. Oxidation or reduction of reversible analytes on the disk electrodes were accompanied by reduction or oxidation, respectively, on the nanopore portion of the bipolar electrode and then monitored by the accompanying oxidation of dihydroresorufin or reduction of resorufin at the remote end of the bipolar electrode, respectively. In both cases, changes in fluorescence intensity were triggered by the reaction of the target couple on the disk electrode, while recovery was largely governed by diffusion of the fluorescent indicator. Reduction of 1 nM of Ru(NH 3) 6 3+ on the nanoelectrode array was detected by monitoring the fluorescence intensity of resorufin, demonstrating high sensitivity fluorescence-mediated electrochemical sensing coupled to self-induced redox cycling.« less

Enhancements for a Dynamic Data Warehousing and Mining System for Large-scale HSCB Data

DTIC Science & Technology

2016-07-20

Intelligent Automation Incorporated Enhancements for a Dynamic Data Warehousing and Mining ...Page | 2 Intelligent Automation Incorporated Monthly Report No. 4 Enhancements for a Dynamic Data Warehousing and Mining System Large-Scale HSCB...including Top Videos, Top Users, Top Words, and Top Languages, and also applied NER to the text associated with YouTube posts. We have also developed UI for

Enhancements for a Dynamic Data Warehousing and Mining System for Large-Scale HSCB Data

DTIC Science & Technology

2016-07-20

Intelligent Automation Incorporated Enhancements for a Dynamic Data Warehousing and Mining ...Page | 2 Intelligent Automation Incorporated Monthly Report No. 4 Enhancements for a Dynamic Data Warehousing and Mining System Large-Scale HSCB...including Top Videos, Top Users, Top Words, and Top Languages, and also applied NER to the text associated with YouTube posts. We have also developed UI for

False Color Image of Volcano Sapas Mons

NASA Technical Reports Server (NTRS)

1991-01-01

This false-color image shows the volcano Sapas Mons, which is located in the broad equatorial rise called Atla Regio (8 degrees north latitude and 188 degrees east longitude). The area shown is approximately 650 kilometers (404 miles) on a side. Sapas Mons measures about 400 kilometers (248 miles) across and 1.5 kilometers (0.9 mile) high. Its flanks show numerous overlapping lava flows. The dark flows on the lower right are thought to be smoother than the brighter ones near the central part of the volcano. Many of the flows appear to have been erupted along the flanks of the volcano rather than from the summit. This type of flank eruption is common on large volcanoes on Earth, such as the Hawaiian volcanoes. The summit area has two flat-topped mesas, whose smooth tops give a relatively dark appearance in the radar image. Also seen near the summit are groups of pits, some as large as one kilometer (0.6 mile) across. These are thought to have formed when underground chambers of magma were drained through other subsurface tubes and lead to a collapse at the surface. A 20 kilometer-diameter (12-mile diameter) impact crater northeast of the volcano is partially buried by the lava flows. Little was known about Atla Regio prior to Magellan. The new data, acquired in February 1991, show the region to be composed of at least five large volcanoes such as Sapas Mons, which are commonly linked by complex systems of fractures or rift zones. If comparable to similar features on Earth, Atla Regio probably formed when large volumes of molten rock upwelled from areas within the interior of Venus known as'hot spots.' Magellan is a NASA spacecraft mission to map the surface of Venus with imaging radar. The basic scientific instrument is a synthetic aperture radar, or SAR, which can look through the thick clouds perpetually shielding the surface of Venus. Magellan is in orbit around Venus which completes one turn around its axis in 243 Earth days. That period of time, one Venus day, is the length of a Magellan mapping cycle. The spacecraft completed its first mapping cycle and primary mission on May 15, 1991, and immediately began its second cycle. During the first cycle, Magellan mapped more than 80 percent of the planet's surface and the current and subsequent cycles of equal duration will provide complete mapping of Venus. Magellan was launched May 4, 1989, aboard the space shuttle Atlantis and went into orbit around Venus August 10, 1990.

Temperature distributions and thermal stresses in a graded zirconia/metal gas path seal system for aircraft gas turbine engines

NASA Technical Reports Server (NTRS)

Taylor, C. M.; Bill, R. C.

1978-01-01

A ceramic/metallic aircraft gas turbine outer gas path seal designed for improved engine performance was studied. Transient temperature and stress profiles in a test seal geometry were determined by numerical analysis. During a simulated engine deceleration cycle from sea-level takeoff to idle conditions, the maximum seal temperature occurred below the seal surface, therefore the top layer of the seal was probably subjected to tensile stresses exceeding the modulus of rupture. In the stress analysis both two- and three-dimensional finite element computer programs were used. Predicted trends of the simpler and more easily usable two-dimensional element programs were borne out by the three-dimensional finite element program results.

International Space Station Passive Thermal Control System Analysis, Top Ten Lessons-Learned

NASA Technical Reports Server (NTRS)

Iovine, John

2011-01-01

The International Space Station (ISS) has been on-orbit for over 10 years, and there have been numerous technical challenges along the way from design to assembly to on-orbit anomalies and repairs. The Passive Thermal Control System (PTCS) management team has been a key player in successfully dealing with these challenges. The PTCS team performs thermal analysis in support of design and verification, launch and assembly constraints, integration, sustaining engineering, failure response, and model validation. This analysis is a significant body of work and provides a unique opportunity to compile a wealth of real world engineering and analysis knowledge and the corresponding lessons-learned. The analysis lessons encompass the full life cycle of flight hardware from design to on-orbit performance and sustaining engineering. These lessons can provide significant insight for new projects and programs. Key areas to be presented include thermal model fidelity, verification methods, analysis uncertainty, and operations support.

Hysteresis in column systems

NASA Astrophysics Data System (ADS)

Ivanyi, P.; Ivanyi, A.

2015-02-01

In this paper one column of a telescopic construction of a bell tower is investigated. The hinges at the support of the column and at the connecting joint between the upper and lower columns are modelled with rotational springs. The characteristics of the springs are assumed to be non-linear and the hysteresis property of them is represented with the Preisach hysteresis model. The mass of the columns and the bell with the fly are concentrated to the top of the column. The tolling process is simulated with a cycling load. The elements of the column are considered completely rigid. The time iteration of the non-linear equations of the motion is evaluated by the Crank-Nicolson schema and the implemented non-linear hysteresis is handled by the fix-point technique. The numerical simulation of the dynamic system is carried out under different combination of soft, medium and hard hysteresis properties of hinges.

Near-infrared light-responsive dynamic wrinkle patterns.

PubMed

Li, Fudong; Hou, Honghao; Yin, Jie; Jiang, Xuesong

2018-04-01

Dynamic micro/nanopatterns provide an effective approach for on-demand tuning of surface properties to realize a smart surface. We report a simple yet versatile strategy for the fabrication of near-infrared (NIR) light-responsive dynamic wrinkles by using a carbon nanotube (CNT)-containing poly(dimethylsiloxane) (PDMS) elastomer as the substrate for the bilayer systems, with various functional polymers serving as the top stiff layers. The high photon-to-thermal energy conversion of CNT leads to the NIR-controlled thermal expansion of the elastic CNT-PDMS substrate, resulting in dynamic regulation of the applied strain (ε) of the bilayer system by the NIR on/off cycle to obtain a reversible wrinkle pattern. The switchable surface topological structures can transfer between the wrinkled state and the wrinkle-free state within tens of seconds via NIR irradiation. As a proof-of-concept application, this type of NIR-driven dynamic wrinkle pattern was used in smart displays, dynamic gratings, and light control electronics.

Life cycle assessment to evaluate the environmental impact of biochar implementation in conservation agriculture in Zambia.

PubMed

Sparrevik, Magnus; Field, John L; Martinsen, Vegard; Breedveld, Gijs D; Cornelissen, Gerard

2013-02-05

Biochar amendment to soil is a potential technology for carbon storage and climate change mitigation. It may, in addition, be a valuable soil fertility enhancer for agricultural purposes in sandy and/or weathered soils. A life cycle assessment including ecological, health and resource impacts has been conducted for field sites in Zambia to evaluate the overall impacts of biochar for agricultural use. The life cycle impacts from conservation farming using cultivation growth basins and precision fertilization with and without biochar addition were in the present study compared to conventional agricultural methods. Three different biochar production methods were evaluated: traditional earth-mound kilns, improved retort kilns, and micro top-lit updraft (TLUD) gasifier stoves. The results confirm that the use of biochar in conservation farming is beneficial for climate change mitigation purposes. However, when including health impacts from particle emissions originating from biochar production, conservation farming plus biochar from earth-mound kilns generally results in a larger negative effect over the whole life cycle than conservation farming without biochar addition. The use of cleaner technologies such as retort kilns or TLUDs can overcome this problem, mainly because fewer particles and less volatile organic compounds, methane and carbon monoxide are emitted. These results emphasize the need for a holistic view on biochar use in agricultural systems. Of special importance is the biochar production technique which has to be evaluated from both environmental/climate, health and social perspectives.

TRMM precipitation analysis of extreme storms in South America: Bias and climatological contribution

NASA Astrophysics Data System (ADS)

Rasmussen, K. L.; Houze, R.; Zuluaga, M. D.; Choi, S. L.; Chaplin, M.

2013-12-01

The TRMM (Tropical Rainfall Measuring Mission) satellite was designed both to measure spatial and temporal variation of tropical rainfall around the globe and to understand the factors controlling the precipitation. TRMM observations have led to the realization that storms just east of the Andes in southeastern South America are among the most intense deep convection in the world. For a complete perspective of the impact of intense precipitation systems on the hydrologic cycle in South America, it is necessary to assess the contribution from various forms of extreme storms to the climatological rainfall. However, recent studies have suggested that the TRMM Precipitation Radar (PR) algorithm significantly underestimates surface rainfall in deep convection over land. Prior to investigating the climatological behavior, this research first investigates the range of the rain bias in storms containing four different types of extreme radar echoes: deep convective cores, deep and wide convective cores, wide convective cores, and broad stratiform regions over South America. The TRMM PR algorithm exhibits bias in all four extreme echo types considered here when the algorithm rates are compared to a range of conventional Z-R relations. Storms with deep convective cores, defined as high reflectivity echo volumes that extend above 10 km in altitude, show the greatest underestimation, and the bias is unrelated to their echo top height. The bias in wide convective cores, defined as high reflectivity echo volumes that extend horizontally over 1,000 km2, relates to the echo top, indicating that storms with significant mixed phase and ice hydrometeors are similarly affected by assumptions in the TRMM PR algorithm. The subtropical region tends to have more intense precipitating systems than the tropics, but the relationship between the TRMM PR rain bias and storm type is the same regardless of the climatological regime. The most extreme storms are typically not collocated with regions of high climatological precipitation. A quantitative approach that accounts for the previously described bias using TRMM PR data is employed to investigate the role of the most extreme precipitating systems on the hydrological cycle in South America. These data are first used to investigate the relative contribution of precipitation from the TRMM-identified echo cores to each separate storm in which the convective cores are embedded. The second part of the study assesses how much of the climatological rainfall in South America is accounted for by storms containing deep convective, wide convective, and broad stratiform echo components. Systems containing these echoes produce very different hydrologic responses. From a hydrologic and climatological viewpoint, this empirical knowledge is critical, as the type of runoff and flooding that may occur depends on the specific character of the convective storm and has broad implications for the hydrological cycle in this region.

Where biomedicalisation and magic meet: Therapeutic innovations of elite sports injury in British professional football and cycling.

PubMed

Faulkner, Alex; McNamee, Michael; Coveney, Catherine; Gabe, Jonathan

2017-04-01

Injury is a conspicuous feature of the practice and public spectacle of contemporary elite sports. The paper argues that the 'biomedicalisation' thesis (medico-industrial nexus, techno-scientific drivers, medical optimisation, biologisation, the rise of evidence and health surveillance) goes some way to capturing the use in elite sports injury of some highly specialised mainstream therapies and some highly maverick biological therapies, which are described. Nevertheless, these main strands of biomedicalisation do not capture the full range of these phenomena in the contexts of sports medicine and athletes' practices in accessing innovative, controversial therapies. Drawing on multi-method qualitative research on top-level professional football and cycling in the UK, 2014-2016, we argue that concepts of 'magic' and faith-based healing, mediated by notions of networking behaviour and referral systems, furnish a fuller explanation. We touch on the concept of 'medical pluralism', concluding that this should be revised in order to take account of belief-based access to innovative bio-therapies amongst elite sportspeople and organisations. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Context-dependent consumer control in New England tidal wetlands.

PubMed

Moore, Alexandria

2018-01-01

Recent studies in coastal wetlands have indicated that consumers may play an important role in regulating large-scale ecosystem processes. Predator removal experiments have shown significant differences in above-ground biomass production in the presence of higher level consumers, or predators. These results indicate that predators play an important role in regulating biomass production, but the extent to which this regulation impacts additional ecosystem functions, such as nutrient cycling and organic matter accumulation, is unclear. This study evaluated the impact that consumers have on large-scale ecosystem processes within southern New England tidal wetlands and contributes to the general understanding of trophic control in these systems. I established enclosure cages within three coastal wetlands and manipulated the presence of green crab predators to assess how trophic interactions affect ecosystem functions. Findings suggest that although these consumers may exert some top-down effects, other environmental factors, such as other consumers not studied here or bottom-up interactions, may variably play a larger role in the maintenance of ecosystem processes within the region. These results indicate that the loss of top-down control as an important mechanism influencing ecosystem functions may not hold for all wetlands along the full extent of the New England coastline.

Context-dependent consumer control in New England tidal wetlands

PubMed Central

2018-01-01

Recent studies in coastal wetlands have indicated that consumers may play an important role in regulating large-scale ecosystem processes. Predator removal experiments have shown significant differences in above-ground biomass production in the presence of higher level consumers, or predators. These results indicate that predators play an important role in regulating biomass production, but the extent to which this regulation impacts additional ecosystem functions, such as nutrient cycling and organic matter accumulation, is unclear. This study evaluated the impact that consumers have on large-scale ecosystem processes within southern New England tidal wetlands and contributes to the general understanding of trophic control in these systems. I established enclosure cages within three coastal wetlands and manipulated the presence of green crab predators to assess how trophic interactions affect ecosystem functions. Findings suggest that although these consumers may exert some top-down effects, other environmental factors, such as other consumers not studied here or bottom-up interactions, may variably play a larger role in the maintenance of ecosystem processes within the region. These results indicate that the loss of top-down control as an important mechanism influencing ecosystem functions may not hold for all wetlands along the full extent of the New England coastline. PMID:29771961

Bottom-up meets top-down: tailored raspberry-like Fe3O4-Pt nanocrystal superlattices.

PubMed

Qiu, Fen; Vervuurt, René H J; Verheijen, Marcel A; Zaia, Edmond W; Creel, Erin B; Kim, Youngsang; Urban, Jeffrey J; Bol, Ageeth A

2018-03-29

Supported catalysts are widely used in industry and can be optimized by tuning the composition, chemical structure, and interface of the nanoparticle catalyst and oxide support. Here we firstly combine a bottom up colloidal synthesis method with a top down atomic layer deposition (ALD) process to achieve a raspberry-like Pt-decorated Fe3O4 (Fe3O4-Pt) nanoparticle superlattices. This nanocomposite ensures the precision of the catalyst/support interface, improving the catalytic efficiency of the Fe3O4-Pt nanocomposite system. The morphology of the hybrid nanocomposites resulting from different cycles of ALD was monitored by scanning transmission electron microscopy, giving insight into the nucleation and growth mechanism of the ALD process. X-ray photoelectron spectroscopy studies confirm the anticipated electron transfer from Fe3O4 to Pt through the nanocomposite interface. Photocurrent measurement further suggests that Fe3O4 superlattices with controlled decoration of Pt have substantial promise for energy-efficient photoelectrocatalytic oxygen evolution reaction. This work opens a new avenue for designing supported catalyst architectures via precisely controlled decoration of single component superlattices with noble metals.

An operational global-scale ocean thermal analysis system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clancy, R. M.; Pollak, K.D.; Phoebus, P.A.

1990-04-01

The Optimum Thermal Interpolation System (OTIS) is an ocean thermal analysis system designed for operational use at FNOC. It is based on the optimum interpolation of the assimilation technique and functions in an analysis-prediction-analysis data assimilation cycle with the TOPS mixed-layer model. OTIS provides a rigorous framework for combining real-time data, climatology, and predictions from numerical ocean prediction models to produce a large-scale synoptic representation of ocean thermal structure. The techniques and assumptions used in OTIS are documented and results of operational tests of global scale OTIS at FNOC are presented. The tests involved comparisons of OTIS against an existingmore » operational ocean thermal structure model and were conducted during February, March, and April 1988. Qualitative comparison of the two products suggests that OTIS gives a more realistic representation of subsurface anomalies and horizontal gradients and that it also gives a more accurate analysis of the thermal structure, with improvements largest below the mixed layer. 37 refs.« less

Investigation of failure mechanism of thermal barrier coatings (TBCs) deposited by EB-PVD technique

NASA Astrophysics Data System (ADS)

Shahid, M. R.; Abbas, Musharaf

2013-06-01

Failure mechanism of thermal barrier coatings (TBCs) prepared by electron beam physical vapor deposition (EB-PVD) technique owing to formation of micro cracks was investigated. The TBCs were deposited on the Ni-based super alloy IN-100 and the micro cracks were observed within the top ceramic coat of thermally cycled TBCs at 1050°C. It was observed that these cracks propagate in the ceramic coat in the direction normal to interface while no cracks were observed in the bond coat. SEM/EDS studies revealed that some non-uniform oxides were formed on the interface between ceramic top and metallic bond coat just below the cracks. Study proposed that the cracks were initiated due to stress owing to big difference in Pilling-Bed worth ratio of non-uniform oxides as well as thermal stress, which caused the formation of cracks in top ceramic coat leading to failure of TBCs

Adaptive engine injection for emissions reduction

DOEpatents

Reitz, Rolf D. : Sun, Yong

2008-12-16

NOx and soot emissions from internal combustion engines, and in particular compression ignition (diesel) engines, are reduced by varying fuel injection timing, fuel injection pressure, and injected fuel volume between low and greater engine loads. At low loads, fuel is injected during one or more low-pressure injections occurring at low injection pressures between the start of the intake stroke and approximately 40 degrees before top dead center during the compression stroke. At higher loads, similar injections are used early in each combustion cycle, in addition to later injections which preferably occur between about 90 degrees before top dead center during the compression stroke, and about 90 degrees after top dead center during the expansion stroke (and which most preferably begin at or closely adjacent the end of the compression stroke). These later injections have higher injection pressure, and also lower injected fuel volume, than the earlier injections.

Enhanced dielectric constant and fatigue-resistance of PbZr0.4Ti0.6O3 capacitor with magnetic intermetallic FePt top electrode

NASA Astrophysics Data System (ADS)

Liu, B. T.; Zhao, J. W.; Li, X. H.; Zhou, Y.; Bian, F.; Wang, X. Y.; Zhao, Q. X.; Wang, Y. L.; Guo, Q. L.; Wang, L. X.; Zhang, X. Y.

2010-06-01

Both FePt/PbZr0.4Ti0.6O3(PZT)/Pt and Pt/PZT/Pt ferroelectric capacitors have been fabricated on Si substrates. It is found that up to 109 switching cycles, the FePt/PZT/Pt capacitor, measured at 50 kHz, with polarization decreased by 57%, is superior to the Pt/PZT/Pt capacitor by 82%, indicating that an intermetallic FePt top electrode can also improve the fatigue-resistance of a PZT capacitor. Maximum dielectric constants are 980 and 770 for PZT capacitors with FePt and Pt, respectively. This is attributed to the interface effect between PZT film and the top electrode since the interfacial capacitance of FePt/PZT is 3.5 times as large as that of Pt/PZT interface.

Sedimentary architecture and depositional controls of a Pliocene river-dominated delta in the semi-isolated Dacian Basin, Black Sea

NASA Astrophysics Data System (ADS)

Jorissen, Elisabeth L.; de Leeuw, Arjan; van Baak, Christiaan G. C.; Mandic, Oleg; Stoica, Marius; Abels, Hemmo A.; Krijgsman, Wout

2018-06-01

Sedimentological facies models for (semi-)isolated basins are less well developed than those for marine environments, but are critical for our understanding of both present-day and ancient deltaic sediment records in restricted depositional environments. This study considers an 835 m thick sedimentary succession of mid-Pliocene age, which accumulated in the Dacian Basin, a former embayment of the Black Sea. Detailed sedimentological and palaeontological analyses reveal a regression from distal prodelta deposits with brackish water faunas to delta-top deposits with freshwater faunas. Sediments contain frequent hyperpycnal plumes and an enrichment in terrestrial organic material, ichnofossils and in situ brackish and freshwater faunas. Deltaic progradation created thin, sharply-based sand bodies formed by multiple terminal distributary channels, covering a wide depositional area. The system experienced frequent delta-lobe switching, resulting in numerous thin parasequences. Parasequences are overlain by erosive reddish oxidized sand beds, enriched in broken, abraded brackish and freshwater shells. These beds were formed after sediment starvation, on top of abandoned delta lobes during each flooding event. A robust magnetostratigraphic time frame allowed for comparison between the observed sedimentary cyclicity and the amplitude and frequency of astronomical forcing cycles. Our results indicate that parasequence frequencies are significantly higher than the number of time equivalent astronomical cycles. This suggests that delta-lobe switching was due to autogenic processes. We consider the observed facies architecture typical for a delta prograding on a low-gradient slope into a shallow, brackish, protected, semi-isolated basin. Furthermore, in the absence of significant wave and tidal influence, sediment progradation in such a protected depositional setting shaped a delta, strongly river-dominated.

The role of N2O derived from crop-based biofuels, and from agriculture in general, in Earth's climate

PubMed Central

Smith, Keith A.; Mosier, Arvin R.; Crutzen, Paul J.; Winiwarter, Wilfried

2012-01-01

In earlier work, we compared the amount of newly fixed nitrogen (N, as synthetic fertilizer and biologically fixed N) entering agricultural systems globally to the total emission of nitrous oxide (N2O). We obtained an N2O emission factor (EF) of 3–5%, and applied it to biofuel production. For ‘first-generation’ biofuels, e.g. biodiesel from rapeseed and bioethanol from corn (maize), that require N fertilizer, N2O from biofuel production could cause (depending on N uptake efficiency) as much or more global warming as that avoided by replacement of fossil fuel by the biofuel. Our subsequent calculations in a follow-up paper, using published life cycle analysis (LCA) models, led to broadly similar conclusions. The N2O EF applies to agricultural crops in general, not just to biofuel crops, and has made possible a top-down estimate of global emissions from agriculture. Independent modelling by another group using bottom-up IPCC inventory methodology has shown good agreement at the global scale with our top-down estimate. Work by Davidson showed that the rate of accumulation of N2O in the atmosphere in the late nineteenth and twentieth centuries was greater than that predicted from agricultural inputs limited to fertilizer N and biologically fixed N (Davidson, E. A. 2009 Nat. Geosci. 2, 659–662.). However, by also including soil organic N mineralized following land-use change and NOx deposited from the atmosphere in our estimates of the reactive N entering the agricultural cycle, we have now obtained a good fit between the observed atmospheric N2O concentrations from 1860 to 2000 and those calculated on the basis of a 4 per cent EF for the reactive N. PMID:22451102

Effect of freeze-thaw cycles on greenhouse gas fluxes from peat soils

NASA Astrophysics Data System (ADS)

Oh, H. D.; Rezanezhad, F.; Markelov, I.; McCarter, C. P. R.; Van Cappellen, P.

2017-12-01

The ongoing displacement of climate zones by global warming is increasing the frequency and intensity of freeze-thaw cycles in middle and high latitude regions, many of which are dominated by organic soils such as peat. Repeated freezing and thawing of soils changes their physical properties, geochemistry, and microbial community structure, which together govern the biogeochemical cycling of carbon and nutrients. In this presentation, we focus on how freeze-thaw cycles influence greenhouse gas fluxes from peat using a newly developed experimental soil column system that simulates realistic soil temperature profiles during freeze-thaw cycles. We measured the surface and subsurface changes to gas and aqueous phase chemistry to delineate the diffusion pathways and quantify soil greenhouse gas fluxes during freeze-thaw cycles using sulfur hexafluoride (SF6) as a conservative tracer. Three peat columns were assembled inside a temperature controlled chamber with different soil structures. All three columns were packed with 40 cm of undisturbed, slightly decomposed peat, where the soil of two columns had an additional 10 cm layer on top (one with loose Sphagnum moss and one with an impermeable plug). The results indicate that the release of SF6 and CO2 gas from the soil surface was influenced by the recurrent development of a physical ice barrier, which prevented gas exchange between the soil and atmosphere during freezing conditions. With the onset of thawing a pulse of SF6 and CO2 occurred, resulting in a flux of 3.24 and 2095.52 µmol/m2h, respectively, due to the build-up of gases in the liquid-phase pore space during freezing. Additionally, we developed a model to determine the specific diffusion coefficients for each peat column. These data allow us to better predict how increased frequency and intensity of freeze-thaw cycles will affect greenhouse gas emissions in northern peat soils.

Late Mississippian (Chesterian) carbonate to carbonate-clastic cycles in the eastern Illinois Basin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, L.B.; Read, J.F.

1994-03-01

Late Mississippian (Chesterian) rocks of the eastern Illinois Basin in Kentucky and Indiana show depositional cycles (3--20 meters thick) composed of a range of facies deposited during the transition from carbonate-dominated deposition of the Middle Mississippian to the predominantly siliciclastic regime of the Pennsylvanian. Within the basal Ste. Genevieve Formation (30--70 meters thick) there are five predominantly carbonate cycles. Cycle bases vary from thin calcareous sandstone near the northern clastic source to ooid-quartz dolomitic pelletal grainstone and mudstone further south. Massive cross-bedded and channeled ooid-skeletal grainstones represent the cycle tops and are commonly capped by caliche and subaerial breccia, particularlymore » where there was no subsequent siliciclastic deposition. The cycles are interpreted to be driven by fourth-order (400 k.y.) glacio-eustatic sea-level fluctuations based on coincidence of the calculated cycle period with the long-term eccentricity signal, the Late Mississippian onset of Gondwana glaciation and cycle correlation over more than 100 kilometers. The breccia and caliche formed during lowstands, the siliciclastics, eolianites and dolomitic pelletal grainstones are transgressive facies and the ooid-skeletal grainstones represent sea-level highstands.« less

18 CFR 292.205 - Criteria for qualifying cogeneration facilities.

Code of Federal Regulations, 2010 CFR

2010-04-01

... standard. For any topping-cycle cogeneration facility, the useful thermal energy output of the facility... thermal energy output, during the 12-month period beginning with the date the facility first produces... total energy input of natural gas and oil to the facility; or (B) If the useful thermal energy output is...

77 FR 13593 - PowerSmith Cogeneration Project, LP; Notice of Request for Waiver

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-07

...] PowerSmith Cogeneration Project, LP; Notice of Request for Waiver Take notice that on February 27, 2012... CFR 292.205(c), PowerSmith Cogeneration Project, LP (PowerSmith) filed a Request for Waiver, for... Regulations for the topping- cycle cogeneration facility owned and operated by PowerSmith located in Oklahoma...

Data Curation

ERIC Educational Resources Information Center

Mallon, Melissa, Ed.

2012-01-01

In their Top Trends of 2012, the Association of College and Research Libraries (ACRL) named data curation as one of the issues to watch in academic libraries in the near future (ACRL, 2012, p. 312). Data curation can be summarized as "the active and ongoing management of data through its life cycle of interest and usefulness to scholarship,…

Workload Estimates for Combat Engineers in the Desert.

DTIC Science & Technology

1986-04-01

11111_!2 4 MICROCOP RES LU I N !ESICHR 111112 5 l *. ff APPENDIX B-8 BUILD A PROTECTIVE POSITION FOR A 155-MM TOWED HOWITZER 1. Terrain. Sandy Desert...the repeated cycles of dissolving calcium, silicon, and ferric compounds in the soil, followed by rapid evapora- tion. The result is a cemented top

Thermionic combustor application to combined gas and steam turbine power plants

NASA Astrophysics Data System (ADS)

Miskolczy, G.; Wang, C. C.; Lieb, D. P.; Margulies, A. E.; Fusegni, L. J.; Lovell, B. J.

A design for the insertion of thermionic converters into the wall of a conventional combustor to produce electricity in a topping cycle is described, and a study for applications in gas and steam generators of 70 and 30 MW is evaluated for engineering and economic feasibility. Waste heat from the thermionic elements is used to preheat the combustor air; the heat absorbed by the elements plus further quenching of the exhaust gases with ammonia is projected to reduce NO(x) emissions to acceptable levels. Schematics, flow diagrams, and components of a computer model for cost projections are provided. It was found that temperatures around the emitters must be maintained above 1,600 K, with maximum efficiency and allowable temperature at 1,800 K, while collectors generate maximally at 950 K, with a corresponding work function of 1.5 eV. Cost sensitive studies indicate an installed price of $475/kW for the topping cycle, with improvements in thermionic converter characteristics bringing the cost to $375/kW at a busbar figure of 500 mills/kWh.

Soil Carbon Cycling - More than Changes in Soil Organic Carbon Stocks

NASA Astrophysics Data System (ADS)

Lorenz, K.

2015-12-01

Discussions about soil carbon (C) sequestration generally focus on changes in soil organic carbon (SOC) stocks. Global SOC mass in the top 1 m was estimated at about 1325 Pg C, and at about 3000 Pg C when deeper soil layers were included. However, both inorganically and organically bound carbon forms are found in soil but estimates on global soil inorganic carbon (SIC) mass are even more uncertain than those for SOC. Globally, about 947 Pg SIC may be stored in the top 1 m, and especially in arid and semi-arid regions SIC stocks can be many times great than SOC stocks. Both SIC and SOC stocks are vulnerable to management practices, and stocks may be enhanced, for example, by optimizing net primary production (NPP) by fertilization and irrigation (especially optimizing belowground NPP for enhancing SOC stocks), adding organic matter (including black C for enhancing SOC stocks), and reducing soil disturbance. Thus, studies on soil C stocks, fluxes, and vulnerability must look at both SIC and SOC stocks in soil profiles to address large scale soil C cycling.

Changes in soil nitrogen cycling under Norway spruce logging residues on a clear-cut

NASA Astrophysics Data System (ADS)

Smolander, Aino; Lindroos, Antti-Jussi; Kitunen, Veikko

2016-04-01

In Europe, forest biomass is increasingly being used as a source of energy to replace fossil fuels. In practice, this means that logging residues, consisting of green branches and stem tops, are more commonly harvested. In 2012 logging residues were harvested from about one third of clear-cuts in Finland. Our aim was to study how logging residues affect soil organic matter quality, in particular soil N cycling processes and composition of certain groups of plant secondary compounds, tannins and terpenes. Compounds in these groups were of interest because they are abundant in logging residues, and they have been shown to control soil N cycling. In connection with clear-cutting a Norway spruce stand in southern Finland, we established a controlled field experiment by building logging residue piles (40 kg/m2) on study plots. The piles consisted of fresh spruce branches and tops with green foliage. Control plots with no residues were included (0 kg/m2). Changes in soil organic matter properties have now been monitored for three growing seasons. Logging residues affected organic layer properties strongly. For example, they increased net nitrification and nitrate concentrations. There were also increases in the concentrations of certain terpenes and condensed tannins due to the residues. The significance of logging residues on soil processes and properties will be shown.

The Behavioral Type of a Top Predator Drives the Short-Term Dynamic of Intraguild Predation.

PubMed

Michalko, Radek; Pekár, Stano

2017-03-01

Variation in behavior among individual top predators (i.e., the behavioral type) can strongly shape pest suppression in intraguild predation (IGP). However, the effect of a top predator's behavioral type-namely, foraging aggressiveness (number of killed divided by prey time) and prey choosiness (preference degree for certain prey type)-on the dynamic of IGP may interact with the relative abundances of top predator, mesopredator, and pest. We investigated the influence of the top predator's behavioral type on the dynamic of IGP in a three-species system with a top predator spider, a mesopredator spider, and a psyllid pest using a simulation model. The model parameters were estimated from laboratory experiments and field observations. The top predator's behavioral type altered the food-web dynamics in a context-dependent manner. The system with an aggressive/nonchoosy top predator, without prey preferences between pest and mesopredator, suppressed the pest more when the top predator to mesopredator abundance ratio was high. In contrast, the system with a timid/choosy top predator that preferred the pest to the mesopredator was more effective when the ratio was low. Our results show that the behavioral types and abundances of interacting species need to be considered together when studying food-web dynamics, because they evidently interact. To improve biocontrol efficiency of predators, research on the alteration of their behavioral types is needed.

On the sensitivity of the diurnal cycle in the Amazon to convective intensity

PubMed Central

Taylor, Patrick C.; Dodson, Jason B.; Tawfik, Ahmed B.

2016-01-01

Abstract Climate and reanalysis models contain large water and energy budget errors over tropical land related to the misrepresentation of diurnally forced moist convection. Motivated by recent work suggesting that the water and energy budget is influenced by the sensitivity of the convective diurnal cycle to atmospheric state, this study investigates the relationship between convective intensity, the convective diurnal cycle, and atmospheric state in a region of frequent convection—the Amazon. Daily, 3‐hourly satellite observations of top of atmosphere (TOA) fluxes from Clouds and the Earth's Radiant Energy System Ed3a SYN1DEG and precipitation from Tropical Rainfall Measuring Mission 3B42 data sets are collocated with twice daily Integrated Global Radiosonde Archive observations from 2002 to 2012 and hourly flux tower observations. Percentiles of daily minimum outgoing longwave radiation are used to define convective intensity regimes. The results indicate a significant increase in the convective diurnal cycle amplitude with increased convective intensity. The TOA flux diurnal phase exhibits 1–3 h shifts with convective intensity, and precipitation phase is less sensitive. However, the timing of precipitation onset occurs 2–3 h earlier and the duration lasts 3–5 h longer on very convective compared to stable days. While statistically significant changes are found between morning atmospheric state and convective intensity, variations in upper and lower tropospheric humidity exhibit the strongest relationships with convective intensity and diurnal cycle characteristics. Lastly, convective available potential energy (CAPE) is found to vary with convective intensity but does not explain the variations in Amazonian convection, suggesting that a CAPE‐based convective parameterization will not capture the observed behavior without incorporating the sensitivity of convection to column humidity. PMID:27867784

Specificity protein 1 regulates topoisomerase IIβ expression in SH-SY5Y cells during neuronal differentiation.

PubMed

Guo, Hui; Cao, Cuili; Chi, Xueqian; Zhao, Junxia; Liu, Xia; Zhou, Najing; Han, Shuo; Yan, Yongxin; Wang, Yanling; Xu, Yannan; Yan, Yunli; Cui, Huixian; Sun, Hongxia

2014-10-01

Topoisomerase IIβ (top IIβ) is a nuclear enzyme with an essential role in neural development. The regulation of top IIβ gene expression during neural differentiation is poorly understood. Functional analysis of top IIβ gene structure displayed a GC box sequence in its transcription promoter, which binds the nuclear transcription factor specificity protein 1 (Sp1). Sp1 regulates gene expression via multiple mechanisms and is essential for early embryonic development. This study seeks to determine whether Sp1 regulates top IIβ gene expression during neuronal differentiation. For this purpose, human neuroblastoma SH-SY5Y cells were induced to neuronal differentiation in the presence of all-trans retinoic acid (RA) for 5 days. After incubation with 10 μM RA for 3-5 days, a majority of the cells exited the cell cycle to become postmitotic neurons, characterized by the presence of longer neurite outgrowths and expression of the neuronal marker microtubule-associated protein-2 (MAP2). Elevated Sp1 and top IIβ mRNA and protein levels were detected and found to be positively correlated with the differentiation stage. Chromatin immunoprecipitation assay demonstrated an increased recruitment of Sp1 to the top IIβ promoter after RA treatment. Mithramycin A, a compound that interferes with Sp1 binding to GC-rich DNA sequences, downregulated the expression of top IIβ, resulting in reduced expression of MAP2 and decreased neurite length compared with the control group. Our results indicate that Sp1 regulates top IIβ expression by binding to the GC box of the gene promoter during neuronal differentiation in SH-SY5Y cells. © 2014 Wiley Periodicals, Inc.

Measurement of Atmospheric CO2 Column Concentrations to Cloud Tops With a Pulsed Multi-Wavelength Airborne Lidar

NASA Technical Reports Server (NTRS)

Mao, Jianping; Ramanathan, Anand; Abshire, James B.; Kawa, Stephan R.; Riris, Haris; Allan, Graham R.; Rodriguez, Michael R.; Hasselbrack, William E.; Sun, Xiaoli; Numata, Kenji;

Measurement of atmospheric CO2 column concentrations to cloud tops with a pulsed multi-wavelength airborne lidar

NASA Astrophysics Data System (ADS)

Mao, Jianping; Ramanathan, Anand; Abshire, James B.; Kawa, Stephan R.; Riris, Haris; Allan, Graham R.; Rodriguez, Michael; Hasselbrack, William E.; Sun, Xiaoli; Numata, Kenji; Chen, Jeff; Choi, Yonghoon; Yang, Mei Ying Melissa

2018-01-01

We have measured the column-averaged atmospheric CO2 mixing ratio to a variety of cloud tops by using an airborne pulsed multi-wavelength integrated-path differential absorption (IPDA) lidar. Airborne measurements were made at altitudes up to 13 km during the 2011, 2013 and 2014 NASA Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) science campaigns flown in the United States West and Midwest and were compared to those from an in situ sensor. Analysis of the lidar backscatter profiles shows the average cloud top reflectance was ˜ 5 % for the CO2 measurement at 1572.335 nm except to cirrus clouds, which had lower reflectance. The energies for 1 µs wide laser pulses reflected from cloud tops were sufficient to allow clear identification of CO2 absorption line shape and then to allow retrievals of atmospheric column CO2 from the aircraft to cloud tops more than 90 % of the time. Retrievals from the CO2 measurements to cloud tops had minimal bias but larger standard deviations when compared to those made to the ground, depending on cloud top roughness and reflectance. The measurements show this new capability helps resolve CO2 horizontal and vertical gradients in the atmosphere. When used with nearby full-column measurements to ground, the CO2 measurements to cloud tops can be used to estimate the partial-column CO2 concentration below clouds, which should lead to better estimates of surface carbon sources and sinks. This additional capability of the range-resolved CO2 IPDA lidar technique provides a new benefit for studying the carbon cycle in future airborne and space-based CO2 missions.

Sequence architecture of the Palaeocene Transitional Facies and Response to Tectonic Evolution and Sea Level Change in the Lishui Depression, East China Sea

NASA Astrophysics Data System (ADS)

Li, D.

2016-12-01

The Lishui Depression (LD) is a polycyclic rift basin located in the southwestern of the East China Sea Shelf Basin. From bottom to top, the Palaeocene strata sequentially comprise the Yueguifeng (YGF), Lingfeng (LF) and Mingyuefeng Formations (MYF). The YGF clastic deposits were produced by a continental lacustrine. The LF and MYF were a set of coal-bearing strata formed by marine transgressive-regressive cycles. The Palaeocene depositional cycle is divided into two second-order sequences, namely SQII1 (YGF, 66.5-60Ma) and SQII2 (LF and MYF, 60-53Ma), which can be interpreted as the initial rifting sequence and the strong rifting sequence respectively that controlled by episodic tectonic subsidence, namely Yandang and Oujiang movements. The SQII1 includes only one third-order sequence, namely SQIII1, which is constituted by lake transgressive systems tract (LTST) and lake regressive systems tract (LRST). The SQII2 can be subdivided into four third-order sequences, namely SQIII2 (Lower LF, 60-57Ma), SQIII3 (Upper LF, 57-55Ma), SQIII4 (Lower MYF, 55-54.5Ma) and SQIII5 (Upper MYF, 54.5-53Ma). In the SQIII2 period, LD suffered massive transgression and the sustained high relative sea level led to the only development of transgressive systems tract (TST) and highstand systems tract (HST). In the SQIII3 period, the relative sea level declined and simultaneously two sets of incised valley were recognized on the seismic reflection with no lowstand fan developed. So the SQIII3 is considered to be composed of basin margin systems tract (BMST, similar to the shelf margin systems tract), TST and HST. Early SQIII4 (55Ma ), the relative sea level started global rapid declining and the LST of LD developed a completed system of prograding wedge, incised valley and basin floor fan. While the TST developed a retrograding marine sediments and the HST was characterized by a typical foreset parasequences. In SQIII5 period, the global sea level continuously rose and the sedimentary cycle of LD was only composed of TST and HST.

An Intercomparison Between Radar Reflectivity and the IR Cloud Classification Technique for the TOGA-COARE Area

NASA Technical Reports Server (NTRS)

Carvalho, L. M. V.; Rickenbach, T.

1999-01-01

Satellite infrared (IR) and visible (VIS) images from the Tropical Ocean Global Atmosphere - Coupled Ocean Atmosphere Response Experiment (TOGA-COARE) experiment are investigated through the use of Clustering Analysis. The clusters are obtained from the values of IR and VIS counts and the local variance for both channels. The clustering procedure is based on the standardized histogram of each variable obtained from 179 pairs of images. A new approach to classify high clouds using only IR and the clustering technique is proposed. This method allows the separation of the enhanced convection in two main classes: convective tops, more closely related to the most active core of the storm, and convective systems, which produce regions of merged, thick anvil clouds. The resulting classification of different portions of cloudiness is compared to the radar reflectivity field for intensive events. Convective Systems and Convective Tops are followed during their life cycle using the IR clustering method. The areal coverage of precipitation and features related to convective and stratiform rain is obtained from the radar for each stage of the evolving Mesoscale Convective Systems (MCS). In order to compare the IR clustering method with a simple threshold technique, two IR thresholds (Tir) were used to identify different portions of cloudiness, Tir=240K which roughly defines the extent of all cloudiness associated with the MCS, and Tir=220K which indicates the presence of deep convection. It is shown that the IR clustering technique can be used as a simple alternative to identify the actual portion of convective and stratiform rainfall.

An integrative top-down and bottom-up qualitative model construction framework for exploration of biochemical systems.

PubMed

Wu, Zujian; Pang, Wei; Coghill, George M

Computational modelling of biochemical systems based on top-down and bottom-up approaches has been well studied over the last decade. In this research, after illustrating how to generate atomic components by a set of given reactants and two user pre-defined component patterns, we propose an integrative top-down and bottom-up modelling approach for stepwise qualitative exploration of interactions among reactants in biochemical systems. Evolution strategy is applied to the top-down modelling approach to compose models, and simulated annealing is employed in the bottom-up modelling approach to explore potential interactions based on models constructed from the top-down modelling process. Both the top-down and bottom-up approaches support stepwise modular addition or subtraction for the model evolution. Experimental results indicate that our modelling approach is feasible to learn the relationships among biochemical reactants qualitatively. In addition, hidden reactants of the target biochemical system can be obtained by generating complex reactants in corresponding composed models. Moreover, qualitatively learned models with inferred reactants and alternative topologies can be used for further web-lab experimental investigations by biologists of interest, which may result in a better understanding of the system.

Energy Beam Highways Through the Skies

NASA Technical Reports Server (NTRS)

Myrabo, Leik N.

1996-01-01

The emergence of Energy Beam Flight Transportation Systems could dramatically change the way we travel in the 21st Century. A framework for formulating 'Highways of Light' and the top level architectures that invoke radically new Space Power Grid infrastructure, are introduced. Basically, such flight systems, hereafter called Lightcraft, would employ off-board energy beam sources (either laser or microwave) to energize on-board dependent 'motors' -- instead of the traditional autonomous 'engines' with their on-board energy sources (e.g., chemical fuels). Extreme reductions in vehicle dry mass appear feasible with the use of off-board power and a high degree of on-board artificial intelligence. Such vehicles may no longer need airports for refueling (since they require no propellant), and could possibly pick up travelers at their homes -- before motoring over to one of many local boost stations, for the flight out. With off-board power, hyper-energetic acceleration performance and boost-glide trajectories become feasible. Hypersonic MS airbreathing propulsion can enable boosts up to twice escape velocity, which will cut trip times to the moon down to 5.5 hours. The predominant technological, environmental and social factors that will result from such transportation systems will be stressed. This presentation first introduces the remote source siting options for the space power system infrastructure, and then provides three representative laser/microwave Lightcraft options (derived from historical Case Studies): i.e., 'Acorn', 'Toy Top', and 'Disc.' Next the gamut of combined-cycle engine options developed for these Lightcraft are examined -- to illuminate the 'emerging technologies' that must be harnessed to produce flight hardware. Needed proof-of concept experiments are identified, along with the Macro-Level Issues that can springboard these revolutionary concepts into hardware reality.

Carbon Fluxes and Transport Along the Terrestrial Aquatic Continuum

NASA Astrophysics Data System (ADS)

Butman, D. E.; Kolka, R.; Fennel, K.; Stackpoole, S. M.; Trettin, C.; Windham-Myers, L.

2017-12-01

Terrestrial wetlands, inland surface waters, tidal wetlands and estuaries, and the coastal ocean are distinct aquatic ecosystems that integrate carbon (C) fluxes and processing among the major earth system components: the continents, oceans, and atmosphere. The development of the 2nd State of the Carbon Cycle Report (SOCCR2) noted that incorporating the C cycle dynamics for these ecosystems was necessary to reconcile some of the gaps associated with the North American C budget. We present major C stocks and fluxes for Canada, Mexico and the United States. North America contains nearly 42% of the global terrestrial wetland area. Terrestrial wetlands, defined as soils that are seasonally or permanently inundated or saturated, contain significant C stocks equivalent to 174,000 Tg C in the top 40 cm of soil. While terrestrial wetlands are a C sink of approximately 64 Tg C yr-1, they also emit 21 Tg of CH4 yr-1. Inland waters are defined as lakes, reservoirs, rivers, and streams. Carbon fluxes, which include lateral C export to the coast, riverine and lacustrine CO2 emissions, and C burial in lakes and reservoirs are estimated at 507 Tg yr-1. Estuaries and tidal wetlands assimilate C and nutrients from uplands and rivers, and their total C stock is 1,323 Tg C in the top 1 m of soils and sediment. Accounting for soil accretion, lateral C flux, and CO2 assimilation and emission, tidal wetlands and estuaries are net sinks with a total flux equal to 6 Tg C yr-1. The coastal ocean and sea shelfs, defined as non-estuarine waters within 200 nautical miles (370 km) of the coast, function as net sinks, with the air-sea exchange of CO2 estimated at 150 Tg C yr-1. In total, fluxes from these four aquatic ecosystems are equal to a loss of 302 Tg C yr-1. Including these four discrete fluxes in this assessment demonstrates the importance of linking hydrology and biogeochemical cycling to evaluate the impacts of climate change and human activities on carbon fluxes across the terrestrial-aquatic continuum.

Top shield temperatures, C and K Reactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agar, J.D.

1964-12-28

A modification program is now in progress at the C and K Reactors consisting of an extensive renovation of the graphite channels in the vertical safety rod ststems. The present VSR channels are being enlarged by a graphite coring operation and channel sleeves will be installed in the larger channels. One problem associated with the coring operation is the danger of damaging top thermal shield cooling tubes located close to the VSR channels to such an extent that these tubes will have to be removed from service. If such a condition should exist at one or a number of locationsmore » in the top shield of the reactors after reactor startup, the question remains -- what would the resulting temperatures be of the various components of the top shields? This study was initiated to determine temperature distributions in the top shield complex at the C and K Reactors for various top thermal shield coolant system conditions. Since the top thermal shield cooling system at C Reactor is different than those at the K Reactors, the study was conducted separately for the two different systems.« less

Advanced Rigid Ablative TPS

NASA Technical Reports Server (NTRS)

Gasch, Matthew J.

2011-01-01

NASA Exploration Systems Mission Directorate s (ESMD) Entry, Descent, and Landing (EDL) Technology Development Project (TDP) and the NASA Aeronautics Research Mission Directorate s (ARMD) Hypersonics Project are developing new advanced rigid ablators in an effort to substantially increase reliability, decrease mass, and reduce life cycle cost of rigid aeroshell-based entry systems for multiple missions. Advanced Rigid Ablators combine ablation resistant top layers capable of high heat flux entry and enable high-speed EDL with insulating mass-efficient bottom that, insulate the structure and lower the areal weight. These materials may benefit Commercial Orbital Transportation Services (COTS) vendors and may potentially enable new NASA missions for higher velocity returns (e.g. asteroid, Mars). The materials have been thermally tested to 400-450 W/sq cm at the Laser Hardened Materials Evaluation Lab (LHMEL), Hypersonics Materials Evaluation Test System (HyMETS) and in arcjet facilities. Tested materials exhibit much lower backface temperatures and reduced recession over the baseline materials (PICA). Although the EDL project is ending in FY11, NASA in-house development of advanced ablators will continue with a focus on varying resin systems and fiber/resin interactions.

Cogeneration Technology Alternatives Study (CTAS) Volume 5: Analytical approach and results

NASA Technical Reports Server (NTRS)

1980-01-01

Data and information in the area of advanced energy conversion systems for industrial cogeneration applications in the 1985 to 2000 time period are provided. Six current and thirty-six advanced energy conversion systems were defined and combined with appropriate balance of plant equipment. Twenty-six industrial processes were selected from among the high energy consuming industries to serve as a framework for the study. Each conversion system was analyzed as a cogenerator with each industrial plant. Fuel consumption, costs, and environmental intrusion were evaluated and compared to corresponding traditional values. Various cogeneration strategies were analyzed and both topping and bottoming (using industrial by-product heat) applications were included. The advanced energy conversion technologies indicated reduced fuel consumption, costs, and emissions. Typically fuel energy savings of 10 to 25 percent were predicted compared to traditional on site furnaces and utility electricity. Gas turbines and combined cycles indicated high overall annual cost savings. Steam turbines and gas turbines produced high estimated returns. In some applications, diesels were most efficient. The advanced technologies used coal derived fuels, or coal with advanced fluid bed combustion or on site gasification systems.

Lunar base heat pump, phase 1

NASA Technical Reports Server (NTRS)

Goldman, Jeffrey H.; Harvey, A.; Lovell, T.; Walker, David H.

1994-01-01

This report describes the Phase 1 process and analysis used to select a refrigerant and thermodynamic cycle as the basis of a vapor compression heat pump requiring a high temperature lift, then to perform a preliminary design to implement the selected concept, including major component selection. Use of a vapor compression heat pump versus other types was based on prior work performed for the Electric Power Research Institute. A high lift heat pump is needed to enable a thermal control system to remove heat down to 275 K from a habitable volume when the external thermal environment is severe. For example, a long-term lunar base habitat will reject heat from a space radiator to a 325 K environment. The first step in the selection process was to perform an optimization trade study, quantifying the effect of radiator operating temperature and heat pump efficiency on total system mass; then, select the radiator operating temperature corresponding to the lowest system mass. Total system mass included radiators, all heat pump components, and the power supply system. The study showed that lunar night operation, with no temperature lift, dictated the radiator size. To operate otherwise would require a high mass penalty to store power. With the defined radiation surface, and heat pump performances assumed to be from 40 percent to 60 percent of the Carnot ideal, the optimum heat rejection temperature ranged from 387 K to 377 K, as a function of heat pump performance. Refrigerant and thermodynamic cycles were then selected to best meet the previously determined design conditions. The system was then adapted as a ground-based prototype lifting temperature to 360 K (versus 385 K for flight unit) and using readily available commercial-grade components. Over 40 refrigerants, separated into wet and dry compression behavioral types, were considered in the selection process. Refrigerants were initially screened for acceptable critical temperature. The acceptable refrigerants were analyzed in ideal single and two-stage thermodynamic cycles. Top candidates were analyzed assuming realistic component limits and system pressure drops, and were evaluated for other considerations such as safety, environmental impact, and commercial availability. A maximum coefficient of performance (COP) of 56 percent of the Carnot ideal was achievable for a three-stage CFC-11 cycle operating under the flight conditions above. The program was completed by defining a control scheme and by researching and selecting the major components, compressor and heat exchangers, that could be used to implement the thermodynamic cycle selected. Special attention was paid to using similar technologies for the SIRF and flight heat pumps resulting in the commercially available equivalent of the flight unit. A package concept was generated for the components selected and mass and volume estimated.

Critical Zone Services as Environmental Assessment Criteria in Intensively Managed Agricultural Landscapes

NASA Astrophysics Data System (ADS)

Richardson, M.; Kumar, P.

2016-12-01

The critical zone (CZ) includes the biophysical processes occurring from the top of the vegetation canopy to the weathering zone below the groundwater table. CZ services provide a measure for the goods and benefits derived from CZ processes. In intensively managed landscapes (IML), the provisioning, supporting, and regulating services are altered through anthropogenic energy inputs to derive more productivity, as agricultural products, from these landscapes than would be possible under natural conditions. However, the energy or cost equivalents of alterations to CZ functions within landscape profiles are unknown. The valuation of CZ services in energy or monetary terms provides a more concrete tool for characterizing seemingly abstract environmental damages from agricultural production systems. A multi-layer canopy-root-soil model is combined with nutrient and water flux models to simulate the movement of nutrients throughout the soil system. This data enables the measurement of agricultural anthropogenic impacts to the CZ's nutrient cycling supporting services and atmospheric stabilizing regulating services defined by the flux of carbon and nutrients. Such measurements include soil carbon storage, soil carbon respiration, nitrate leaching, and nitrous oxide flux into the atmosphere. Additionally, the socioeconomic values of corn feed and ethanol define the primary productivity supporting services of each crop use.In the debate between feed production and corn-based ethanol production, measured nutrient CZ services can cost up to four times more than traditionally estimated CO2 equivalences for the entire bioenergy production system. Energy efficiency in addition to environmental impacts demonstrate how the inclusion of CZ services is necessary in accounting for the entire life cycle of agricultural production systems. These results conclude that feed production systems are more energy efficient and less environmentally costly than corn-based ethanol systems.

32 CFR 2001.46 - Transmission.

Code of Federal Regulations, 2010 CFR

2010-07-01

... between the U.S., Puerto Rico, or a U.S. possession or trust territory. (1) Top Secret. Top Secret... an authorized government agency courier service; a designated courier or escort with Top Secret clearance; electronic means over approved communications systems. Under no circumstances will Top Secret...

Variations in trace metal and halogen ratios in magmatic gases through an eruptive cycle of the Pu'u O'o vent, Kilauea, Hawaii: July-August 1985

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, T.L.; Zoller, W.H.; Crowe, B.M.

1990-08-10

Particle and gas samples were obtained before and after eruptive episode 35 in July and August 1985 at the fuming Pu'u O'o vent, Kilauea volcano, Hawaii. The sampling system employed consisted of a particle filter followed by four {sup 7}LiOH treated filters to collect acidic gases. The filters were analyzed using instrumental neutron activation analysis (INAA). The results indicate that Br/Cl and Re/Cl ratios do not fluctuate through an eruption cycle but the F/Cl, F/Br and metal/Cl ratios (In and Cd) do change through the cycle. An inverse relationship between F/Cl and metal/Cl was observed. The changes are probably duemore » to influxes of relatively undegassed magma during the repose period releasing fume with lower F/Cl, F/BR and higher metal/Cl ratios. As the magma in the Pu'u O'o conduit gradually degasses either before or several days after an eruptive episode, F/Cl and F/Br ratios increase and the metal/Cl ratios decrease. One sample collected on July 24, two days before eruptive episode 35, did not follow this general trend. This can be explained by a gas pulse from a deeper, less degassed portion of magma making its way to the top of the conduit.« less

A systematic study on drug-response associated genes using baseline gene expressions of the Cancer Cell Line Encyclopedia

NASA Astrophysics Data System (ADS)

Liu, Xiaoming; Yang, Jiasheng; Zhang, Yi; Fang, Yun; Wang, Fayou; Wang, Jun; Zheng, Xiaoqi; Yang, Jialiang

2016-03-01

We have studied drug-response associated (DRA) gene expressions by applying a systems biology framework to the Cancer Cell Line Encyclopedia data. More than 4,000 genes are inferred to be DRA for at least one drug, while the number of DRA genes for each drug varies dramatically from almost 0 to 1,226. Functional enrichment analysis shows that the DRA genes are significantly enriched in genes associated with cell cycle and plasma membrane. Moreover, there might be two patterns of DRA genes between genders. There are significantly shared DRA genes between male and female for most drugs, while very little DRA genes tend to be shared between the two genders for a few drugs targeting sex-specific cancers (e.g., PD-0332991 for breast cancer and ovarian cancer). Our analyses also show substantial difference for DRA genes between young and old samples, suggesting the necessity of considering the age effects for personalized medicine in cancers. Lastly, differential module and key driver analyses confirm cell cycle related modules as top differential ones for drug sensitivity. The analyses also reveal the role of TSPO, TP53, and many other immune or cell cycle related genes as important key drivers for DRA network modules. These key drivers provide new drug targets to improve the sensitivity of cancer therapy.

"Variations in trace metal and halogen ratios in magmatic gases through an eruptive. Cycle of the Pu'u O'o Vent, Kilauea, Hawaii: July-August 1985""

NASA Astrophysics Data System (ADS)

Miller, Theresa L.; Zoller, William H.; Crowe, Bruce M.; Finnegan, David L.

1990-08-01

Particle and gas samples were obtained before and after eruptive episode 35 in July and August 1985 at the fuming Pu'u O'o vent, Kilauea volcano, Hawaii. The sampling system employed consisted of a particle filter followed by four 7LiOH treated filters to collect acidic gases. The filters were analyzed using instrumental neutron activation analysis (INAA). The results indicate that Br/Cl and Re/Cl ratios do not fluctuate through an eruption cycle but the F/Cl, F/Br and metal/Cl ratios (In and Cd) do change through the cycle. An inverse relationship between F/Cl and metal/Cl was observed. The changes are probably due to influxes of relatively undegassed magma during the repose period releasing fume with lower F/Cl, F/Br and higher metal/Cl ratios. As the magma in the Pu'u O'o conduit gradually degasses either before or several days after an eruptive episode, F/Cl and F/Br ratios increase and the metal/Cl ratios decrease. One sample collected on July 24, two days before eruptive episode 35, did not follow this general trend. This can be explained by a gas pulse from a deeper, less degassed portion of magma making its way to the top of the conduit.

Novel carbon-ion fuel cells. Quarterly technical report No. 9, October 1, 1995--December 31, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cocks, F.H.

1995-12-31

This report presents research to develop an entirely new, fundamentally different class of fuel cell using a solid electrolyte that transports carbon ions. This fuel cell would use solid carbon dissolved in molten metal as a fuel reservoir and anode; expensive gaseous or liquid fuel would not be required. Thermodynamic factors favor a carbon-ion fuel cell over other fuel cell designs: a combination of enthalpy, entropy, and Gibbs free energy makes the reaction of solid carbon and oxygen very efficient, and the entropy change allows this efficiency to slightly increase at high temperatures. The high temperature exhaust of the fuelmore » cell would make it useful as a ``topping cycle``, to be followed by conventional steam turbine systems.« less

Microwave-assisted extraction of coumarin and related compounds from Melilotus officinalis (L.) Pallas as an alternative to Soxhlet and ultrasound-assisted extraction.

PubMed

Martino, Emanuela; Ramaiola, Ilaria; Urbano, Mariangela; Bracco, Francesco; Collina, Simona

2006-09-01

Soxhlet extraction, ultrasound-assisted extraction (USAE) and microwaves-assisted extraction (MAE) in closed system have been investigated to determine the content of coumarin, o-coumaric and melilotic acids in flowering tops of Melilotus officinalis. The extracts were analyzed with an appropriate HPLC procedure. The reproducibility of extraction and of chromatographic analysis was proved. Taking into account the extraction yield, the cost and the time, we studied the effects of extraction variables on the yield of the above-mentioned compounds. Better results were obtained with MAE (50% v/v aqueous ethanol, two heating cycles of 5 min, 50 degrees C). On the basis of the ratio extraction yield/extraction time, we therefore propose MAE as the most efficient method.

Transient change in the shape of premixed burner flame with the superposition of pulsed dielectric barrier discharge

NASA Astrophysics Data System (ADS)

Zaima, Kazunori; Sasaki, Koichi

2016-08-01

We investigated the transient phenomena in a premixed burner flame with the superposition of a pulsed dielectric barrier discharge (DBD). The length of the flame was shortened by the superposition of DBD, indicating the activation of combustion chemical reactions with the help of the plasma. In addition, we observed the modulation of the top position of the unburned gas region and the formations of local minimums in the axial distribution of the optical emission intensity of OH. These experimental results reveal the oscillation of the rates of combustion chemical reactions as a response to the activation by pulsed DBD. The cycle of the oscillation was 0.18-0.2 ms, which could be understood as the eigenfrequency of the plasma-assisted combustion reaction system.

A graphene barristor using nitrogen profile controlled ZnO Schottky contacts.

PubMed

Hwang, Hyeon Jun; Chang, Kyoung Eun; Yoo, Won Beom; Shim, Chang Hoo; Lee, Sang Kyung; Yang, Jin Ho; Kim, So-Young; Lee, Yongsu; Cho, Chunhum; Lee, Byoung Hun

2017-02-16

We have successfully demonstrated a graphene-ZnO:N Schottky barristor. The barrier height between graphene and ZnO:N could be modulated by a buried gate electrode in the range of 0.5-0.73 eV, and an on-off ratio of up to 10 7 was achieved. By using a nitrogen-doped ZnO film as a Schottky contact material, the stability problem of previously reported graphene barristors could be greatly alleviated and a facile route to build a top-down processed graphene barristor was realized with a very low heat cycle. This device will be instrumental when implementing logic functions in systems requiring high-performance logic devices fabricated with a low temperature fabrication process such as back-end integrated logic devices or flexible devices on soft substrates.

High-power closed-cycle 4He cryostat with top-loading sample exchange

NASA Astrophysics Data System (ADS)

Piegsa, F. M.; van den Brandt, B.; Kirch, K.

2017-10-01

We report on the development of a versatile cryogen-free laboratory cryostat based upon a commercial pulse tube cryocooler. It provides enough cooling power for continuous recondensation of circulating 4He gas at a condensation pressure of approximately 250 mbar. Moreover, the cryostat allows for exchange of different cryostat-inserts as well as fast and easy ;wet; top-loading of samples directly into the 1 K pot with a turn-over time of less than 75 min. Starting from room temperature and using a 4He cryostat-insert, a base temperature of 1.0 K is reached within approximately seven hours and a cooling power of 250 mW is established at 1.24 K.

Satellite remote sensing and cloud modeling of St. Anthony, Minnesota storm clouds and dew point depression

NASA Technical Reports Server (NTRS)

Hung, R. J.; Tsao, Y. D.

1988-01-01

Rawinsonde data and geosynchronous satellite imagery were used to investigate the life cycles of St. Anthony, Minnesota's severe convective storms. It is found that the fully developed storm clouds, with overshooting cloud tops penetrating above the tropopause, collapsed about three minutes before the touchdown of the tornadoes. Results indicate that the probability of producing an outbreak of tornadoes causing greater damage increases when there are higher values of potential energy storage per unit area for overshooting cloud tops penetrating the tropopause. It is also found that there is less chance for clouds with a lower moisture content to be outgrown as a storm cloud than clouds with a higher moisture content.

Testing of Unmanned Ground Vehicle (UGV) Systems

DTIC Science & Technology

2009-02-12

Emissions - Intra-system EMC TOP 1-2-51253 TOP 1-2-51154 TOP 2-2-61355 Determines whether the item tested meets the electromagnetic radiation ...effects, static electricity, and lightning criteria and the maximum electromagnetic radiation environment to which the test item may be exposed...Form 298 (Rev. 8-98) Prescribed by ANSI Std. Z39-18 2-2-540 Testing of Unmanned Ground Vehicle (UGV) Systems 5c. PROGRAM ELEMENT NUMBER 5d

Evaluation of seismic reflection data in the Davis and Lavender Canyons study area, Paradox Basin, Utah. [Faults, folds, joints, and collapse structures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kitcho, C.A.; Wong, I.G.; Turcotte, F.T.

1986-08-01

Seismic reflection data purchased from petroleum industry brokers and acquired through group speculative surveys were interpreted for information on the regional subsurface geologic structure and stratigraphy within and surrounding the Davis and Lavender Canyons study area in the Paradox Basin of southeastern Utah. Structures of interest were faults, folds, joints, and collapse structures related to salt dissolution. The seismic reflection data were used to interpret stratigraphy by identifying continuous and discontinuous reflectors on the seismic profiles. Thickening and thinning of strata and possible areas of salt flowage or dissolution could be identified from the seismic data. Identifiable reflectors included themore » tops of the Precambrian and Mississippian, a distinctive interbed close to the middle of the Pennsylvanian Paradox salt formation (probably the interval between Salt Cycles 10 and 13), and near the top of the Paradox salt. Of the 56 faults identified from the seismic reflection interpretation, 33 trend northwest, west-northwest, or west, and most affect only the deeper part of the stratigraphic section. These faults are part of the deep structural system found throughout the Paradox Basin, including the fold and fault belt in the northeast part of the basin. The faults bound basement Precambrian blocks that experienced minor activity during Mississippian and early Pennsylvanian deposition, and showed major displacement during early Paradox salt deposition as the Paradox Basin subsided. Based on the seismic data, most of these faults appear to have an upward terminus between the top of the Mississippian and the salt interbed reflector.« less

Participation and performance trends in ‘Ultraman Hawaii’ from 1983 to 2012

PubMed Central

2013-01-01

Background Participation and performance trends have been investigated in a single stage Ironman triathlon such as the ‘Ironman Hawaii,’ but not for a multi-stage ultra-triathlon such as the ‘Ultraman Hawaii’ covering a total distance of 515 km. The aims of this study were to analyze (1) changes in participation and performance, (2) sex-related differences in overall and split time performances, and (3) the age of peak performance in Ultraman Hawaii. Methods Age and race times including split times for 98 women and 570 men who successfully finished Ultraman Hawaii (day 1 with 10-km swimming and 145-km cycling, day 2 with 276-km cycling, and day 3 with 84-km running) between 1983 and 2012 were analyzed. Changes in variables over time of annual winners and annual top three women and men were investigated using simple linear regression analyses. Results The number of female finishers increased (r2 = 0.26, p < 0.01), while the number of male finishers remained stable (r2 = 0.03, p > 0.05). Overall race times decreased for both female (r2 = 0.28, p < 0.01) and male (r2 = 0.14, p < 0.05) winners and for both the annual top three women (r2 = 0.36, p < 0.01) and men (r2 = 0.14, p = 0.02). The sex difference in performance decreased over time from 24.3% to 11.5% (r2 = 0.39, p < 0.01). For the split disciplines, the time performance in cycling on day 1 (r2 = 0.20, p < 0.01) and day 2 decreased significantly for men (r2 = 0.41, p < 0.01) but for women only on day 2 (r2 = 0.45, p < 0.01). Split times showed no changes in swimming and running. The age of the annual winners increased from 28 to 47 years for men (r2 = 0.35, p < 0.01) while it remained stable at 32 ± 6 years for women (r2 < 0.01, p > 0.05). The age of the annual top three finishers increased from 33 ± 6 years to 48 ± 3 years for men (p < 0.01) and from 29 ± 7 years to 49 ± 2 years for women (p < 0.01). Conclusions Both the annual top three women and men improved performance in Ultraman Hawaii during the 1983–2012 period although the age of the annual top three women and men increased. The sex-related difference in performance decreased over time to reach approximately 12% similar to the reports of other endurance and ultra-endurance events. Further investigations are required to better understand the limiting factors of the multi-activities ultra-endurance events taking place over several days. PMID:23916227

Turnover at the Top: Superintendent Vacancies and the Urban School

ERIC Educational Resources Information Center

Buchanan, Bruce

2006-01-01

The leadership turnover in America's largest school districts has increased so rapidly that the average urban superintendent tenure is only about two years. In fact, many urban superintendents are hired knowing that they will either be terminated or forced to resign in a short period of time. This cycle has created a class of superintendents who…

Chemical and mineral control of soil carbon turnover in abandoned tropical pastures

Treesearch

Erika Marin-Spiotta; Christopher W. Swanston; Margaret S. Torn; Whendee L. Silver; Sarah D. Burton

2008-01-01

We investigated changes in soil carbon (C) cycling with reforestation across a long-term, replicated chronosequence of tropical secondary forests regrowing on abandoned pastures. We applied CP MAS 13C NMR spectroscopy and radiocarbon modeling to soil density fractions from the top 10 cm to track changes in C chemistry and turnover during...

Science and Engineering Doctorate Recipients Entering the Labor Market: Income Disparities for Underrepresented Minorities

ERIC Educational Resources Information Center

Campbell, Throy Alexander; Adamuti-Trache, Maria

2016-01-01

This study discusses the issue of earning disparities experienced by underrepresented minorities, by examining how earning gaps manifest even at the top of the education degree hierarchy--science and engineering doctorate recipients. The study uses four cycles of data (2003, 2006, 2008, 2010) from the National Science Foundation's Survey of…

75 FR 62144 - Porcelain-on-Steel Cooking Ware From China and Taiwan; Top-of-the-Stove Stainless Steel Cooking...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-07

... changes, if any, in the supply and demand conditions or business cycle for the Domestic Like Product that...-3088. Limited disclosure of business proprietary information (BPI) under an administrative protective... Merchandise. If you are a domestic producer, union/worker group, or trade/business association; import/export...

Mixing of biogenic siliceous and terrigenous clastic sediments: South Belridge field and Beta field, California

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schwartz, D.E.

1990-05-01

The intermixing and interbedding of biogenically derived siliceous sediment with terrigenous clastic sediment in reservoirs of upper Miocene age provides both reservoir rock and seal and influences productivity by affecting porosity and permeability. Miocene reservoirs commonly contain either biogenic-dominated cyclic diatomite, porcelanite, or chert (classic Monterey Formation) or clastic-dominated submarine fan sequences with interbedded or intermixed siliceous members of biogenic origin. Biogenic-clastic cycles, 30-180 ft thick, at South Belridge field were formed by episodic influx of clastic sediment from distant submarine fans mixing with slowly accumulating diatomaceous ooze. The cycles consist of basal silt and pelletized massive diatomaceous mudstone, overlainmore » by burrowed, faintly bedded clayey diatomite and topped by laminated diatomite. Cycle tops have higher porosity and permeability, lower grain density, and higher oil saturation than clay and silt-rich portions of the cycles. Submarine fan sediments forming reservoirs at the Beta field are comprised of interbedded sands and silts deposited in a channelized middle fan to outer fan setting. Individual turbidites display fining-upward sequences, with oil-bearing sands capped by wet micaceous silts. Average sands are moderately to poorly sorted, fine- to medium-grained arkosic arenites. Sands contain pore-filling carbonate and porcelaneous cements. Porcelaneous cement consists of a mixture of opal-A, opal-CT, and chert with montmorillonite and minor zeolite. This cement is an authigenic material precipitated in intergranular pore space. The origin of the opal is biogenic, with recrystallization of diatom frustules (opal-A) into opal-CT lepispheres and quartz crystals. Porcelaneous cement comprises 4-21% of the bulk volume of the rock. Seventy percent of the bulk volume of the cement is micropore space.« less

Carbonate Platform Development and Stromatolite Morphogenesis: Constraints on Environmental and Biological Evolution

NASA Technical Reports Server (NTRS)

Grotzinger, John P.

2003-01-01

Work has been completed on the digital mapping of a terminal Proterozoic reef complex in Namibia. This complex formed an isolated carbonate platform developed downdip on a carbonate ramp of the Nama Group. The stratigraphic evolution of the platform was digitally reconstructed from an extensive dataset that was compiled by using digital surveying technologies. The platform comprises three accommodation cycles in which each subsequent cycle experienced progressively greater influence of a long-term accommodation increase. Aggradation and progradation during the first cycle resulted in a flat, uniform, sheet-like platform. The coarsening and shallowing-upward sequence representing the first cycle is dominated by columnar stromatolitic thrombolites and massive dolostones with interbedded mudstone-grainstone at the base of the sequence grading into cross-bedded dolostones. The second cycle features aggradation, formation of a distinct margin containing thrombolite mounds and domes, and the development of a bucket geometry. Columnar stromatolitic thrombolites dominate the platform interior. The final stage of platform development shows a deepening trend with initial aggradation and formation of well-bedded, thin deposits in the interior and mound development at the margins. While the interior drowned, the platform margin kept up with rising sea level and a complex pinnacle reef formed containing fused and coalesced thrombolite mounds flanked by bioclastic grainstones (containing Cloudina and Namacalathus fossils) and collapse breccias. A set of isolated large thrombolite mounds flanked by shales indicate the final stage of the carbonate platform. During a progressive increase in accommodation, a flat-topped isolated carbonate platform becomes aerially less extensive by either backstepping or formation of smaller pinnacles or a combination of both. The overall geometric evolution of the studied platform from flat-topped to bucket with elevated margins is recorded in many Proterozoic and Phanerozoic isolated carbonate platforms with similar dimensions. The terminal Proterozoic, microbial-dominated, isolated carbonate platform of this study clearly illustrates that the answer to accommodation changes was already familiar among carbonate platforms before the dawn of metazoan-dominated platforms.

Solar Signals in CMIP-5 Simulations: The Stratospheric Pathway

NASA Technical Reports Server (NTRS)

Mitchell, D.M.; Misios, S.; Gray, L. J.; Tourpali, K.; Matthes, K.; Hood, L.; Schmidt, H.; Chiodo, G.; Thieblemont, R.; Rozanov, E.;

Dynamics of a vertical-flow windrow vermicomposting system.

PubMed

Hanc, Ales; Castkova, Tereza; Kuzel, Stanislav; Cajthaml, Tomas

2017-11-01

Large-scale vermicomposting under outdoor conditions may differ from small-scale procedures in the laboratory. The present study evaluated changes in selected properties of a large-scale vertical-flow windrow vermicomposting system with continuous feeding with household biowaste. The windrow profile was divided into five layers of differing thickness and age after more than 12 months of vermicomposting. The top layer (0-30 cm, age <3 months) was characterised by partially decomposed organic matter with a high pH value and an elevated carbon/nitrogen (C/N) ratio. The earthworm biomass was 15 g kg -1 with a population density of 125 earthworms per kilogram predominantly found in clusters. The greatest amount of fungi (3.5 µg g -1 dw) and bacteria (62 µg g -1 dw) (expressed as phospholipid fatty acid analysis) was found in this layer. Thus, the top layer could be used for an additional cycle of windrow vermicomposting and for the preparation of aqueous extracts to protect plants against diseases. The lower layers (graduated by 30 cm and by 3 months of age) were mature as reflected by the low content of ammonia nitrogen, ratio of ammonia to nitrate nitrogen and dissolved organic carbon, and high ion-exchange capacity and its ratio to carbon. These layers were characterised by elevated values for electrical conductivity, total content of nutrients, available magnesium content, and a relatively large bacterial/fungal ratio. On the basis of the observed properties, the bottom layers were predetermined as effective fertilisers.

Impacts of convection on high-temperature aquifer thermal energy storage

NASA Astrophysics Data System (ADS)

Beyer, Christof; Hintze, Meike; Bauer, Sebastian

2016-04-01

Seasonal subsurface heat storage is increasingly used in order to overcome the temporal disparities between heat production from renewable sources like solar thermal installations or from industrial surplus heat and the heat demand for building climatisation or hot water supply. In this context, high-temperature aquifer thermal energy storage (ATES) is a technology to efficiently store and retrieve large amounts of heat using groundwater wells in an aquifer to inject or withdraw hot or cold water. Depending on the local hydrogeology and temperature amplitudes during high-temperature ATES, density differences between the injected hot water and the ambient groundwater may induce significant convective flow components in the groundwater flow field. As a consequence, stored heat may accumulate at the top of the storage aquifer which reduces the heat recovery efficiency of the ATES system. Also, an accumulation of heat at the aquifer top will induce increased emissions of heat to overlying formations with potential impacts on groundwater quality outside of the storage. This work investigates the impacts of convective heat transport on the storage efficiency of a hypothetical high-temperature ATES system for seasonal heat storage as well as heat emissions to neighboring formations by numerical scenario simulations. The coupled groundwater flow and heat transport code OpenGeoSys is used to simulate a medium scale ATES system operating in a sandy aquifer of 20 m thickness with an average groundwater temperature of 10°C and confining aquicludes at top and bottom. Seasonal heat storage by a well doublet (i.e. one fully screened "hot" and "cold" well, respectively) is simulated over a period of 10 years with biannual injection / withdrawal cycles at pumping rates of 15 m³/h and for different scenarios of the temperature of the injected water (20, 35, 60 and 90 °C). Simulation results show, that for the simulated system significant convective heat transport sets in when injection temperatures exceed 35°C. Convection results in an accumulation of heat below the upper confining layer. The consequential increase of the heat plume contact area with this formation results in increased conductive heat transfer. Also, thermal gradients between the heat plume and the ambient groundwater increase with injection temperature, which increases heat conduction within the aquifer. Both effects reduce the thermal recovery of the ATES system. At the end of the 10th injection / withdrawal cycle the efficiency of thermal recovery thus reaches about 76 % for the 20°C scenario, 74% for 35°C, 71 % for 60°C and 66 % for the 90 °C scenario. Sensitivity analysis indicates that permeability in horizontal and vertical directions are controlling factors for the extent of convective heat displacement. Also, heat plume dimensions are influenced by permeability, and to a lesser extent by heat capacity and porosity of the aquifer. The planning of high-temperature ATES at a specific site hence requires a careful investigation of hydraulic and heat transport properties. Acknowledgments: This work is part of the ANGUS+ project (www.angusplus.de) and funded by the German Federal Ministry of Education and Research (BMBF) as part of the energy storage initiative "Energiespeicher".

Be discs in coplanar circular binaries: Phase-locked variations of emission lines

NASA Astrophysics Data System (ADS)

Panoglou, Despina; Faes, Daniel M.; Carciofi, Alex C.; Okazaki, Atsuo T.; Baade, Dietrich; Rivinius, Thomas; Borges Fernandes, Marcelo

2018-01-01

In this paper, we present the first results of radiative transfer calculations on decretion discs of binary Be stars. A smoothed particle hydrodynamics code computes the structure of Be discs in coplanar circular binary systems for a range of orbital and disc parameters. The resulting disc configuration consists of two spiral arms, and this can be given as input into a Monte Carlo code, which calculates the radiative transfer along the line of sight for various observational coordinates. Making use of the property of steady disc structure in coplanar circular binaries, observables are computed as functions of the orbital phase. Some orbital-phase series of line profiles are given for selected parameter sets under various viewing angles, to allow comparison with observations. Flat-topped profiles with and without superimposed multiple structures are reproduced, showing, for example, that triple-peaked profiles do not have to be necessarily associated with warped discs and misaligned binaries. It is demonstrated that binary tidal effects give rise to phase-locked variability of the violet-to-red (V/R) ratio of hydrogen emission lines. The V/R ratio exhibits two maxima per cycle; in certain cases those maxima are equal, leading to a clear new V/R cycle every half orbital period. This study opens a way to identifying binaries and to constraining the parameters of binary systems that exhibit phase-locked variations induced by tidal interaction with a companion star.

Plasma shaping and its impact on the pedestal of ASDEX Upgrade: edge stability and inter-ELM dynamics at varied triangularity

NASA Astrophysics Data System (ADS)

Laggner, F. M.; Wolfrum, E.; Cavedon, M.; Dunne, M. G.; Birkenmeier, G.; Fischer, R.; Willensdorfer, M.; Aumayr, F.; The EUROfusion MST1 Team; The ASDEX Upgrade Team

2018-04-01

The plasma shape, in particular the triangularity (δ), impacts on the pedestal stability. A scan of δ including a variation of heating power (P heat) and gas puff was performed to study the behaviour of edge localised modes (ELMs) and the pre-ELM pedestal stability for different plasma shapes. Generally, at higher δ the pedestal top electron density (n e) is enhanced and the ELM repetition frequency (f ELM) is reduced. For all δ, the pedestal top n e is already fully established to its pre-ELM value during the initial recovery phase of the n e pedestal, which takes place immediately after the ELM crash. The lowering of the f ELM with increasing δ is related to longer pedestal recovery phases, especially the last pre-ELM phase with clamped pedestal gradients (after the recovery phases of the n e and electron temperature (T e) pedestal) is extended. In all investigated discharge intervals, the pre-ELM pedestal profiles are in agreement with peeling-ballooning (PB) theory. Over the investigated range of δ, two well-separated f ELM bands are observed in several discharge intervals. Their occurrence is linked to the inter-ELM pedestal stability. In both kinds of ELM cycles the pedestal evolves similarly, however, the ‘fast’ ELM cycle occurs before the global plasma stored energy (W MHD) increases, which then provides a stabilising effect on the pedestal, extending the inter-ELM period in the case of the ‘slow’ ELM cycle. At the end of a ‘fast’ ELM cycle the n e profile is radially shifted inwards relative to the n e profile at the end of a ‘slow’ ELM cycle, leading to a reduced pressure gradient. The appearance of two f ELM bands suggests that the pedestal becomes more likely PB unstable in certain phases of the inter-ELM evolution. Such a behaviour is possible because the evolution of the global plasma is not rigidly coupled to the evolution of the pedestal structure on the timescales of an ELM cycle.

Plasmon absorption modulator systems and methods

DOEpatents

Kekatpure, Rohan Deodatta; Davids, Paul

2014-07-15

Plasmon absorption modulator systems and methods are disclosed. A plasmon absorption modulator system includes a semiconductor substrate, a plurality of quantum well layers stacked on a top surface of the semiconductor substrate, and a metal layer formed on a top surface of the stack of quantum well layers. A method for modulating plasmonic current includes enabling propagation of the plasmonic current along a metal layer, and applying a voltage across the stack of quantum well layers to cause absorption of a portion of energy of the plasmonic current by the stack of quantum well layers. A metamaterial switching system includes a semiconductor substrate, a plurality of quantum well layers stacked on a top surface of the semiconductor substrate, and at least one metamaterial structure formed on a top surface of the stack of quantum well layers.

Generation of flat-top pulsed magnetic fields with feedback control approach.

PubMed

Kohama, Yoshimitsu; Kindo, Koichi

2015-10-01

We describe the construction of a simple, compact, and cost-effective feedback system that produces flat-top field profiles in pulsed magnetic fields. This system is designed for use in conjunction with a typical capacitor-bank driven pulsed magnet and was tested using a 60-T pulsed magnet. With the developed feedback controller, we have demonstrated flat-top magnetic fields as high as 60.64 T with an excellent field stability of ±0.005 T. The result indicates that the flat-top pulsed magnetic field produced features high field stability and an accessible field strength. These features make this system useful for improving the resolution of data with signal averaging.

A novel Brassica-rhizotron system to unravel the dynamic changes in root system architecture of oilseed rape under phosphorus deficiency.

PubMed

Yuan, Pan; Ding, Guang-Da; Cai, Hong-Mei; Jin, Ke-Mo; Broadley, Martin Roger; Xu, Fang-Sen; Shi, Lei

2016-08-01

An important adaptation of plants to phosphorus (P) deficiency is to alter root system architecture (RSA) to increase P acquisition from the soil, but soil-based observations of RSA are technically challenging, especially in mature plants. The aim of this study was to investigate the root development and RSA of oilseed rape (Brassica napus L.) under low and high soil P conditions during an entire growth cycle. A new large Brassica-rhizotron system (approx. 118-litre volume) was developed to study the RSA dynamics of B. napus 'Zhongshuang11' in soils, using top-soils supplemented with low P (LP) or high P (HP) for a full plant growth period. Total root length (TRL), root tip number (RTN), root length density (RLD), biomass and seed yield traits were measured. TRL and RTN increased more rapidly in HP than LP plants from seedling to flowering stages. Both traits declined from flowering to silique stages, and then increased slightly in HP plants; in contrast, root senescence was observed in LP plants. RSA parameters measured from the polycarbonate plates were empirically consistent with analyses of excavated roots. Seed yield and shoot dry weights were closely associated positively with root dry weights, TRL, RLD and RTN at both HP and LP. The Brassica-rhizotron system is an effective method for soil-based root phenotyping across an entire growth cycle. Given that root senescence is likely to occur earlier under low P conditions, crop P deficiency is likely to affect late water and nitrogen uptake, which is critical for efficient resource use and optimal crop yields. © The Author 2016. Published by Oxford University Press on behalf of the Annals of Botany Company. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Bottom-up assessment of the Net Ecosystem Carbon Balance of Russian forests in 2010 for comparison to Top-down estimates.

NASA Astrophysics Data System (ADS)

Maksyutov, S. S.; Shvidenko, A.; Shchepashchenko, D.

2014-12-01

The verified full carbon assessment of Russian forests (FCA) is based on an Integrated Land Information System (ILIS) that includes a multi-layer and multi-scale GIS with basic resolution of 1 km and corresponding attributive databases. The ILIS aggregates all available information about ecosystems and landscapes, sets of empirical and semi-empirical data and aggregations, data of different inventories and surveys, and multi-sensor remote sensing data. The ILIS serves as an information base for application of the landscape-ecosystem approach (LEA) of the FCA and as a systems design for comparison and mutual constraints with other methods of study of carbon cycling of forest ecosystems (eddy covariance; process models; inverse modeling; and multi-sensor application of remote sensing). The LEA is based on a complimentary use of the flux-based method with some elements of the pool-based method. Introduction of climatic parameters of individual years in the LEA, as well as some process-based elements, allows providing a substantial decrease of the uncertainties of carbon cycling yearly indicators of forest ecosystems. Major carbon pools (live biomass, coarse woody debris, soil organic carbon) are estimated based on data on areas, distribution and major biometric characteristics of Russian forests presented in form of the ILIS for the country. The major fluxes accounted for include Net Primary Production (NPP), Soil Heterotrophic Respiration (SHR), as well as fluxes caused by decomposition of Coarse Woody Debris (CWD), harvest and use of forest products, fluxes caused by natural disturbances (fire, insect outbreaks, impacts of unfavorable environment) and lateral fluxes to hydrosphere and lithosphere. Use of landscape-ecosystem approach resulted in the NECB at 573±140 Tg C yr-1 (CI 0.9). While the total carbon sink is high, large forest areas, particularly on permafrost, serve as a carbon source. The ratio between net primary production and soil heterotrophic respiration, together with natural and human-induced disturbances are major drivers of the magnitude and spatial distribution of the NECB of forest ecosystems. We also present comparison to the recent top-down estimates of the Siberian carbon sink.

Wave-Rotor-Enhanced Gas Turbine Engine Demonstrator

NASA Technical Reports Server (NTRS)

Welch, Gerard E.; Paxson, Daniel E.; Wilson, Jack; Synder, Philip H.

1999-01-01

The U.S. Army Research Laboratory, NASA Glenn Research Center, and Rolls-Royce Allison are working collaboratively to demonstrate the benefits and viability of a wave-rotor-topped gas turbine engine. The self-cooled wave rotor is predicted to increase the engine overall pressure ratio and peak temperature by 300% and 25 to 30%. respectively, providing substantial improvements in engine efficiency and specific power. Such performance improvements would significantly reduce engine emissions and the fuel logistics trails of armed forces. Progress towards a planned demonstration of a wave-rotor-topped Rolls-Royce Allison model 250 engine has included completion of the preliminary design and layout of the engine, the aerodynamic design of the wave rotor component and prediction of its aerodynamic performance characteristics in on- and off-design operation and during transients, and the aerodynamic design of transition ducts between the wave rotor and the high pressure turbine. The topping cycle increases the burner entry temperature and poses a design challenge to be met in the development of the demonstrator engine.

Performance Enhancement of One and Two-Shaft Industrial Turboshaft Engines Topped With Wave Rotors

NASA Astrophysics Data System (ADS)

Fatsis, Antonios

2018-05-01

Wave rotors are rotating equipment designed to exchange energy between high and low enthalpy fluids by means of unsteady pressure waves. In turbomachinery, they can be used as topping devices to gas turbines aiming to improve performance. The integration of a wave rotor into a ground power unit is far more attractive than into an aeronautical application, since it is not accompanied by any inconvenience concerning the over-weight and extra dimensioning. Two are the most common types of ground industrial gas turbines: The one-shaft and the two-shaft engines. Cycle analysis for both types of gas turbine engines topped with a four-port wave rotor is calculated and their performance is compared to the performance of the baseline engine accordingly. It is concluded that important benefits are obtained in terms of specific work and specific fuel consumption, especially compared to baseline engines with low compressor pressure ratio and low turbine inlet temperature.

Sequence Stratigraphic Framework Analysis of Putaohua Oil Reservoir in Chaochang Area of Songliao Basin

NASA Astrophysics Data System (ADS)

Chang, Yan; Liu, Dameng; Yao, Yanbin

2018-01-01

The regional structure of the Changchang area in the Songliao Basin is located on the Chaoyangou terrace and Changchunling anticline belt in the central depression of the northern part of the Songliao Basin, across the two secondary tectonic units of the Chaoyanggou terrace and Changchunling anticline. However, with the continuous development of oil and gas, the unused reserves of Fuyu oil reservoir decreased year by year, and the oil field faced a serious shortage of reserve reserves. At the same time, during the evaluation process, a better oil-bearing display was found during the drilling and test oil in the Putao depression to the Chaoyanggou terraces, the Yudong-Taipingchuan area, and in the process of drilling and testing oil in the Putaohua reservoir. Zhao41, Zhao18-1, Shu38 and other exploration wells to obtain oil oil, indicating that the area has a further evaluation of the potential. Based on the principle of stratification, the Putao area was divided into three parts by using the core, logging and logging. It is concluded that the middle and western strata of the study area are well developed, including three sequences, one cycle from bottom to top (three small layers), two cycles (one small layer), three cycles (two small layers) Rhythm is positive-anti-positive. From the Midwest to the southeastern part of the strata, the strata are overtaken, the lower strata are missing, and the top rhythms become rhythmic.

Global climatology of planetary boundary layer top obtained from multi-satellite GPS RO observations

NASA Astrophysics Data System (ADS)

Basha, Ghouse; Kishore, P.; Ratnam, M. Venkat; Ravindra Babu, S.; Velicogna, Isabella; Jiang, Jonathan H.; Ao, Chi O.

2018-05-01

Accurate estimation of the planetary boundary layer (PBL) top is essential for air quality prediction, weather forecast, and assessment of regional and global climate models. In this article, the long-term climatology of seasonal, global distribution of PBL is presented by using global positioning system radio occultation (GPSRO) based payloads such as Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC), Communication/Navigation Outage Forecast System (C/NOFS), TerraSAR-X, and The Gravity Recovery and Climate Experiment (GRACE) from the year 2006-2015. We used Wavelet Covariance Transform (WCT) technique for precise PBL top identification. The derived PBL top from GPSRO data is rigorously evaluated with GPS radiosonde data over Gadanki. Significant seasonal variation is noticed in both radiosonde and GPSRO observations. Further, we compared the PBL obtained GPS RO with global radiosonde network and observed very good correlation. The number of occultations reaching down to 500 m and retrieval rate of PBL top from WCT method is very high in mid-latitudes compared to tropical latitudes. The global distribution of PBL top shows significant seasonal variation with higher during summer followed by spring, fall, and minimum in winter. In the vicinity of Inter Tropical Convergence Zone (ITCZ), the PBL top is high over eastern Pacific compared to other regions. The ERA-Interim reanalysis data underestimate the PBL top compared to GPS RO observations due to different measurement techniques. The seasonal variation of global averaged PBL top over land and ocean shows contrasting features at different latitude bands.

Construction and analysis of circular RNA molecular regulatory networks in liver cancer.

PubMed

Ren, Shuangchun; Xin, Zhuoyuan; Xu, Yinyan; Xu, Jianting; Wang, Guoqing

2017-01-01

Liver cancer is the sixth most prevalent cancer, and the third most frequent cause of cancer-related deaths. Circular RNAs (circRNAs), a kind of special endogenous ncRNAs, have been coming back to the forefront of cancer genomics research. In this study, we used a systems biology approach to construct and analyze the circRNA molecular regulatory networks in the context of liver cancer. We detected a total of 127 differentially expressed circRNAs and 3,235 differentially expressed mRNAs. We selected the top-5 upregulated circRNAs to construct a circRNA-miRNA-mRNA network. We enriched the pathways and gene ontology items and determined their participation in cancer-related pathways such as p53 signaling pathway and pathways involved in angiogenesis and cell cycle. Quantitative real-time PCR was performed to verify the top-five circRNAs. ROC analysis showed circZFR, circFUT8, circIPO11 could significantly distinguish the cancer samples, with an AUC of 0.7069, 0.7575, and 0.7103, respectively. Our results suggest the circRNA-miRNA-mRNA network may help us further understand the molecular mechanisms of tumor progression in liver cancer, and reveal novel biomarkers and therapeutic targets.

Satellite-based trends of solar radiation and cloud parameters in Europe

NASA Astrophysics Data System (ADS)

Pfeifroth, Uwe; Bojanowski, Jedrzej S.; Clerbaux, Nicolas; Manara, Veronica; Sanchez-Lorenzo, Arturo; Trentmann, Jörg; Walawender, Jakub P.; Hollmann, Rainer

2018-04-01

Solar radiation is the main driver of the Earth's climate. Measuring solar radiation and analysing its interaction with clouds are essential for the understanding of the climate system. The EUMETSAT Satellite Application Facility on Climate Monitoring (CM SAF) generates satellite-based, high-quality climate data records, with a focus on the energy balance and water cycle. Here, multiple of these data records are analyzed in a common framework to assess the consistency in trends and spatio-temporal variability of surface solar radiation, top-of-atmosphere reflected solar radiation and cloud fraction. This multi-parameter analysis focuses on Europe and covers the time period from 1992 to 2015. A high correlation between these three variables has been found over Europe. An overall consistency of the climate data records reveals an increase of surface solar radiation and a decrease in top-of-atmosphere reflected radiation. In addition, those trends are confirmed by negative trends in cloud cover. This consistency documents the high quality and stability of the CM SAF climate data records, which are mostly derived independently from each other. The results of this study indicate that one of the main reasons for the positive trend in surface solar radiation since the 1990's is a decrease in cloud coverage even if an aerosol contribution cannot be completely ruled out.

DIRECT-CYCLE, BOILING-WATER NUCLEAR REACTOR

DOEpatents

Harrer, J.M.; Fromm, L.W. Jr.; Kolba, V.M.

1962-08-14

A direct-cycle boiling-water nuclear reactor is described that employs a closed vessel and a plurality of fuel assemblies, each comprising an outer tube closed at its lower end, an inner tube, fuel rods in the space between the tubes and within the inner tube. A body of water lying within the pressure vessel and outside the fuel assemblies is converted to saturated steam, which enters each fuel assembly at the top and is converted to superheated steam in the fuel assembly while it is passing therethrough first downward through the space between the inner and outer tubes of the fuel assembly and then upward through the inner tube. (AEC)

Top Four Trends in Student Information Systems

ERIC Educational Resources Information Center

Weathers, Robert

2013-01-01

The modern student information systems (SIS) is a powerful administrative tool with robust functionality. As such, it is essential that school and district administrators consider the top trends in modern student information systems before going forward with system upgrades or new purchases. These trends, described herein, are: (1) Support for…

Hot-water aquifer storage: A field test

NASA Astrophysics Data System (ADS)

Parr, A. D.; Molz, F. J.; Andersen, P. F.

1980-03-01

The basic water injection cycle used in a large-scale field study of heat storage in a confined aquifer near Mobile, Alabama is described. Water was pumped from an upper semi-confined aquifer, passed through a boiler where it was heated to a temperature of about 55 C, and injected into a medium sand confined aquifer. The injection well has a 6-inch (15-cm) partially-penetrating steel screen. The top of the storage formation is about 40 meters below the surface and the formation thickness is about 21 meters. In the first cycle, after a storage period of 51 days, the injection well was pumped until the temperature of the recovered water dropped to 33 c. At that point 55,300 cubic meters of water had been withdrawn and 66 percent of the injected energy had been recovered. The recovery period for the second cycle continued until the water temperature was 27.5 C and 100,100 cubic meters of water was recovered. At the end of the cycle about 90 percent of the energy injected during the cycle had been recovered.

Farming in a fish tank.

PubMed

Youth, H

1992-01-01

Water, fish, and vegetables are all things that most developing countries do not have enough of. There is a method of food production called aquaculture that integrates fish and vegetable growing and conserves and purifies water at the same time. A working system that grows vegetables and fish for regional supermarkets in Massachusetts is a gravity fed system. At the top of the system is a 3,000 gallon fish rearing tank that measures 12 feet in diameter. Water trickles out of the tank and fish wastes are captured which can be composted and used in farm fields. The water goes into a bio filter that contains bacteria which convert harmful ammonia generated from fish waste into beneficial nitrate. Then the water flows into 100 foot long hydroponic tanks where lettuce grows. A 1/6 horsepower pump return the purified water to the fish tank and completes the cycle. The key to success is maintaining a balance between the fish nutrients and waste and the plants nutrients and waste. The system is estimated to produce 35,000 heads of lettuce and 2 tons of fish annually which translates into $23,500. The system could be adapted to developing countries with several modifications to reduce the start up cost.

Monitoring industrial wastewater by online GC-MS with direct aqueous injection.

PubMed

Wortberg, M; Ziemer, W; Kugel, M; Müller, H; Neu, H-J

2006-03-01

An online GC-MS-system for automated monitoring of crude wastewater at a complex chemical production site is presented. The modular system is, in principal, based on commercial equipment, but utilizes a special, two-stage injector, which consists of a splitless vaporization chamber on top of a PTV injector filled with Tenax. This set-up enables direct injection of wastewater. Almost 140 volatile and semi-volatile compounds are calibrated down to 1 mg L(-1), which is sufficient for analysis of the influent of the wastewater-treatment plant. Two instruments analyze alternately, every 20 min, and the instrument cycle time is 40 min. The quantitative results are transferred to a database which is connected to a process-control system. Depending on the nature and concentration of a compound, an alarm can be generated and the wastewater stream can be diverted into an "off spec tank" if necessary. The GC-MS-system operates quasi-continuously with a system availability >98%. Data quality is automatically controlled in each run and by daily analysis of a quality-control sample. The development of a novel stacked PTV-PTV injector design to expand the range of analytes to selected basic compounds is described.

Chemical and mineral control of soil carbon turnover in abandoned tropical pastures.

Treesearch

Erika Marín-Spiotta; Christopher W. Swanston; Margaret S. Torn; Whendee L. Silver; Sarah D. Burton

2007-01-01

We investigated changes in soil carbon (C) cycling with reforestation across a long-term, replicated chronosequence of tropical secondary forests regrowing on abandoned pastures. We applied CP MAS 13C NMR spectroscopy and radiocarbon modeling to soil density fractions from the top 10 cm to track changes in C chemistry and turnover during secondary forest establishment...

Smart Armor Conceptual Design

DTIC Science & Technology

1992-04-30

Figure 111.2.16 Stress Contour After 800 Cycles With Smart Actuation... . . . . . . . . 37 Figure 111.3.1 A Schematic of an Electrostatic Micromotor ...43 Figure 111.3.2 Top and Cross-Sectional Views of a Micromotor ..... . ............ ... 44 Figure 111.3.3 Shape Memory Alloy...as a Micromotor . ... 45 Figure 111.3.4 A Typical Induced Drive Mechanism ........ .. 46 Figure 111.3.5 Ceramic Plate. . . . . ............. 47 Figure

Selective Reverberation Cancellation via Adaptive Beamforming

DTIC Science & Technology

1985-12-01

pteropods , euphausiids and fish. The diurnal migrating cycle of the DSL and its frequency-selective backscattering properties have been studied inten...1976]. It is characterized by large fluctuations of temperature and salinity. In addition to the usual seasonal variations 72 in the top ~30m...a period of two years has revealed multiple scattering layers with substantial seasonal variations [Anderson, 1981]. The maximum measured volume

Assignment Problem for the U.S. Marine Corps: Regional, Culture, and Language Familiarization Program

DTIC Science & Technology

2013-12-01

patients. The top trading cycle is popular in market design because it can be Pareto efficient and strategy proof when making assignments such as...29 1. Results for Group 1: Platoons 1 and 2 .............................................29 2...Results for Group 2: Platoons 3 and 4 .............................................31 3. Results for Group 3: Platoons 5 and 6

Plasticity mechanism for copper extrusion in through-silicon vias for three-dimensional interconnects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jiang, Tengfei; Spinella, Laura; Im, Jay

2013-11-18

In this paper, we demonstrated the plasticity mechanism for copper (Cu) extrusion in through-silicon via structures under thermal cycling. The local plasticity was directly observed by synchrotron x-ray micro-diffraction near the top of the via with the amount increasing with the peak temperature. The Cu extrusion was confirmed by Atomic Force Microscopy (AFM) measurements and found to be consistent with the observed Cu plasticity behavior. A simple analytical model elucidated the role of plasticity during thermal cycling, and finite element analyses were carried out to confirm the plasticity mechanism as well as the effect of the via/Si interface. The modelmore » predictions were able to account for the via extrusions observed in two types of experiments, with one representing a nearly free sliding interface and the other a strongly bonded interface. Interestingly, the AFM extrusion profiles seemed to contour with the local grain structures near the top of the via, suggesting that the grain structure not only affects the yield strength of the Cu and thus its plasticity but could also be important in controlling the pop-up behavior and the statistics for a large ensemble of vias.« less

Ecosystem development of Haizhou Bay Ecological Restoration Area from 2003 to 2013

NASA Astrophysics Data System (ADS)

Wang, Teng; Li, Yunkai; Xie, Bin; Zhang, Hu; Zhang, Shuo

2017-12-01

Two Ecopath mass-balance models were implemented for evaluating the structure and function of Haizhou Bay Ecological Restoration Area ecosystem using 14 ecological indicators in two distinctive years (2003 and 2013). The results showed that the size of HZERA ecosystem became larger as total biomass was increased in last decade, especially in primary producer and zooplankton groups. Total system throughput increased from 7496.00 t km-2 yr-1 to 9547.54 t km-2 yr-1. The P/R (production/respiration) ratio decreased over the decade. Finn's cycling index and Finn's mean path length increased over the decade. No keystone species (KS) occurred during ten years; however, evidences of top-down control in 2003 and 2013 models were demonstrated by high KS value belonging to Lophius litulon group in food web. Drawing upon Odum's theory of ecosystem maturity, the structured, web-like ecosystem of 2013 model had developed into a highly mature system compared with that of 2003 model.

Feasibility of flywheel energy storage systems for applications in future space missions

NASA Technical Reports Server (NTRS)

Santo, G. Espiritu; Gill, S. P.; Kotas, J. F.; Paschall, R.

1995-01-01

The objective of this study was to examine the overall feasibility of deploying electromechanical flywheel systems in space used for excess energy storage. Results of previous Rocketdyne studies have shown that the flywheel concept has a number of advantages over the NiH2 battery, including higher specific energy, longer life and high roundtrip efficiency. Based on this prior work, this current study was broken into four subtasks. The first subtask investigated the feasibility of replacing the NiH2 battery orbital replacement unit (ORU) on the international space station (ISSA) with a flywheel ORU. In addition, a conceptual design of a generic flywheel demonstrator experiment implemented on the ISSA was completed. An assessment of the life cycle cost benefits of replacing the station battery energy storage ORU's with flywheel ORU's was performed. A fourth task generated a top-level development plan for critical flywheel technologies, the flywheel demonstrator experiments and its evolution into the production unit flywheel replacement ORU.

Near-infrared light–responsive dynamic wrinkle patterns

PubMed Central

Hou, Honghao; Yin, Jie

2018-01-01

Dynamic micro/nanopatterns provide an effective approach for on-demand tuning of surface properties to realize a smart surface. We report a simple yet versatile strategy for the fabrication of near-infrared (NIR) light–responsive dynamic wrinkles by using a carbon nanotube (CNT)–containing poly(dimethylsiloxane) (PDMS) elastomer as the substrate for the bilayer systems, with various functional polymers serving as the top stiff layers. The high photon-to-thermal energy conversion of CNT leads to the NIR-controlled thermal expansion of the elastic CNT-PDMS substrate, resulting in dynamic regulation of the applied strain (ε) of the bilayer system by the NIR on/off cycle to obtain a reversible wrinkle pattern. The switchable surface topological structures can transfer between the wrinkled state and the wrinkle-free state within tens of seconds via NIR irradiation. As a proof-of-concept application, this type of NIR-driven dynamic wrinkle pattern was used in smart displays, dynamic gratings, and light control electronics. PMID:29740615

Eddy Flux Tower in Ankasa Park : a new facility for the study of the carbon cycle of primary tropical forests in Africa

NASA Astrophysics Data System (ADS)

Stefani, P.; Belelli Marchesini, L.; Consalvo, C.; Forgione, A.; Bombelli, A.; Grieco, E.; Mazzenga, F.; Vittorini, E.; Papale, D.; Valentini, R.

2009-04-01

An Eddy Covariance station for the monitoring of CO2 and energy fluxes over a primary tropical forest in Ghana is operative as part of the CarboAfrica eddy covariance network. The facility, located in the Ankasa Conservation area (05° 16' 11.2''N; 02° 41' 41.55'' W), includes a 65 m tall steel tower equipped with a system enabling the measurements of fluxes at the top of the structure, of CO2, air temperature and humidity along a vertical profile and of relevant physical parameters of the forest ecosystem. The Ankasa flux tower is the first in the African continent collecting data on CO2 exchanges over a tropical primary forest, and from its activity a breakthrough in the understanding of the carbon cycling in this kind of environment is expected. Moreover the knowledge gained on the carbon balance of this primary forest can be used as a reference to thoroughly evaluate the impacts of deforestation, beyond the decrease of carbon stocks. The analysis of preliminary data collected in the first week of August 2008 shows a daily uptake of 1.33±0.73 gC m-2 d-1 (mean±s.e.) and highlights the large magnitude of the storage of CO2 within the canopy space causing a discrepancy between the CO2 flux observed at the top of the tower (Fc) and the overall net ecosystem exchange (NEE). During night-time NEE reveals a respiration rate up to 4 times higher than Fc while in the first hours after dawn assimilation of CO2 in the canopy space is sensed at the top level of measurement with about 3 hours of delay. Associated to the tower site, a field campaign to estimate biomass and biodiversity was carried out. Two transects were demarcated for a total surface of 2 ha. Each transect measuring 1000 m x 10 m, they were divided into 10 subplots and intersected each other at the centre and they were perpendicular to one another. The point of intersection is located on the tower where they are located all the instrumentation for monitoring carbon fluxes. All the data is still being processed but the first analysis has already highlighted the high biodiversity that characterizes Ankasa forest.

AlGaAs top solar cell for mechanical attachment in a multi-junction tandem concentrator solar cell stack

NASA Technical Reports Server (NTRS)

Dinetta, L. C.; Hannon, M. H.; Mcneely, J. B.; Barnett, A. M.

1991-01-01

The AstroPower self-supporting, transparent AlGaAs top solar cell can be stacked upon any well-developed bottom solar cell for improved system performance. This is an approach to improve the performance and scale of space photovoltaic power systems. Mechanically stacked tandem solar cell concentrator systems based on the AlGaAs top concentrator solar cell can provide near term efficiencies of 36 percent (AMO, 100x). Possible tandem stack efficiencies greater than 38 percent (100x, AMO) are feasible with a careful selection of materials. In a three solar cell stack, system efficiencies exceed 41 percent (100x, AMO). These device results demonstrate a practical solution for a state-of-the-art top solar cell for attachment to an existing, well-developed solar cell.

Influence of Finishing and Polishing Techniques and Abrasion on Transmittance and Roughness of Composite Resins.

PubMed

Carneiro, Pma; Ramos, T M; de Azevedo, C S; de Lima, E; de Souza, Shj; Turbino, M L; Cesar, P F; Matos, A B

The aim of this study was to evaluate the influence of finishing and polishing systems and toothbrush abrasion on transmittance (T) and surface roughness (Ra) of three composite resins (Filtek Z350 XT, Tetric N-Ceram, and IPS Empress Direct). Eighteen resin disks (10 mm diameter × 2 mm thick) finished by polyester strips had initial surface smoothness recorded, representing phase 1 (P1). Specimens were divided into three groups (n=6) according to the finishing/polishing instrument used (OneGloss, TopGloss, and Sof-Lex) to compose phase 2 samples (P2). Then specimens were subjected to 514 cycles of toothbrush simulation using a toothpaste slurry, with a constant load applied to soft bristles, and were then washed (phase 3=P3). After each phase, the specimens were examined by an optical profiler and spectrophotometer to measure Ra and T. Data were analyzed by analysis of variance, Tukey and Pearson tests. T values were statistically influenced by composite resin ( p=0.000) and phase of measurement ( p=0.000) factors, while the finishing/polishing system used ( p=0.741) did not affect T. On the other hand, Ra values were statistically affected by the factor finishing/polishing system ( p=0.000), but not by composite resin ( p=0.100) and phase of measurement ( p=0.451). Tetric N-Ceram and Empress Direct presented higher values of roughness when polished by OneGloss, while TopGloss and Sof-Lex showed a lower roughness. It can be concluded that composite resins transmitted more light after dental abrasion. Transmittance of composite resins was not modified by the distinct roughness created by finishing/polishing instruments.

Conflicting drainage patterns in the Matera Horst Area, southern Italy

NASA Astrophysics Data System (ADS)

Beneduce, P.; Festa, V.; Francioso, R.; Schiattarella, M.; Tropeano, M.

The Matera Horst (“ Murgia materana”) is included in the Apulian plateau, basically formed by Mesozoic shallow-water carbonates. The zone is located in a present-day temperate belt and form a flat-topped morphostructural large element inside the foreland area of the southern Apennines. This horst is bordered by high-angle faults and surrounded by downthrown blocks covered by Plio-Quaternary marine and alluvial sediments. The structural high experienced several morphological cycles from Miocene to Quaternary. In particular, three evolutionary stages can be recognized at least. The first stage is currently represented by relics of a flat erosional landscape at the top of the relieves. The second one is testified by gentle slopes with wide glacis at the foothills, locally covered by coarse waste deposits. During the third stage a series of marine terraces formed and a drainage system developed creating both bland valleys and well-defined channels and gorges. The latter streams deeply carve the Cretaceous limestone of the Matera Horst for they represent the morphological response to the tectonic uplift of the area and clearly post-date the former features. Since the fluvial net took place on Pleistocene covers, later widely eroded, it is possible to conclude that the major part of the Matera Horst drainage system represents a good example of superimposition. However, low order streams and segments of major rivers appear to be structurally controlled, as suggested by comparison with the fracture system. Further, also open synclines and gently steeped flexures may locally exert a driving control on minor streams. These apparently conflicting genetic hypotheses can be explained by the role of exhumation of inherited structures of the bedrock in add to a constant interplay between tectonics, erosion and drainage evolution during Quaternary times.

Sensitivity of Numerical Simulations of a Mesoscale Convective System to Ice Hydrometeors in Bulk Microphysical Parameterization

NASA Astrophysics Data System (ADS)

Pu, Zhaoxia; Lin, Chao; Dong, Xiquan; Krueger, Steven K.

2018-01-01

Mesoscale convective systems (MCSs) and their associated cloud properties are the important factors that influence the aviation activities, yet they present a forecasting challenge in numerical weather prediction. In this study, the sensitivity of numerical simulations of an MCS over the US Southern Great Plains to ice hydrometeors in bulk microphysics (MP) schemes has been investigated using the Weather Research and Forecasting (WRF) model. It is found that the simulated structure, life cycle, cloud coverage, and precipitation of the convective system as well as its associated cold pools are sensitive to three selected MP schemes, namely, the WRF single-moment 6-class (WSM6), WRF double-moment 6-class (WDM6, with the double-moment treatment of warm-rain only), and Morrison double-moment (MORR, with the double-moment representation of both warm-rain and ice) schemes. Compared with observations, the WRF simulation with WSM6 only produces a less organized convection structure with a short lifetime, while WDM6 can produce the structure and length of the MCS very well. Both simulations heavily underestimate the precipitation amount, the height of the radar echo top, and stratiform cloud fractions. With MORR, the model performs well in predicting the lifetime, cloud coverage, echo top, and precipitation amount of the convection. Overall results demonstrate the importance of including double-moment representation of ice hydrometeors along with warm-rain. Additional experiments are performed to further examine the role of ice hydrometeors in numerical simulations of the MCS. Results indicate that replacing graupel with hail in the MORR scheme improves the prediction of the convective structure, especially in the convective core region.

An integrated approach to system design, reliability, and diagnosis

NASA Technical Reports Server (NTRS)

Patterson-Hine, F. A.; Iverson, David L.

1990-01-01

The requirement for ultradependability of computer systems in future avionics and space applications necessitates a top-down, integrated systems engineering approach for design, implementation, testing, and operation. The functional analyses of hardware and software systems must be combined by models that are flexible enough to represent their interactions and behavior. The information contained in these models must be accessible throughout all phases of the system life cycle in order to maintain consistency and accuracy in design and operational decisions. One approach being taken by researchers at Ames Research Center is the creation of an object-oriented environment that integrates information about system components required in the reliability evaluation with behavioral information useful for diagnostic algorithms. Procedures have been developed at Ames that perform reliability evaluations during design and failure diagnoses during system operation. These procedures utilize information from a central source, structured as object-oriented fault trees. Fault trees were selected because they are a flexible model widely used in aerospace applications and because they give a concise, structured representation of system behavior. The utility of this integrated environment for aerospace applications in light of our experiences during its development and use is described. The techniques for reliability evaluation and failure diagnosis are discussed, and current extensions of the environment and areas requiring further development are summarized.

An integrated approach to system design, reliability, and diagnosis

NASA Astrophysics Data System (ADS)

Patterson-Hine, F. A.; Iverson, David L.

1990-12-01

The requirement for ultradependability of computer systems in future avionics and space applications necessitates a top-down, integrated systems engineering approach for design, implementation, testing, and operation. The functional analyses of hardware and software systems must be combined by models that are flexible enough to represent their interactions and behavior. The information contained in these models must be accessible throughout all phases of the system life cycle in order to maintain consistency and accuracy in design and operational decisions. One approach being taken by researchers at Ames Research Center is the creation of an object-oriented environment that integrates information about system components required in the reliability evaluation with behavioral information useful for diagnostic algorithms. Procedures have been developed at Ames that perform reliability evaluations during design and failure diagnoses during system operation. These procedures utilize information from a central source, structured as object-oriented fault trees. Fault trees were selected because they are a flexible model widely used in aerospace applications and because they give a concise, structured representation of system behavior. The utility of this integrated environment for aerospace applications in light of our experiences during its development and use is described. The techniques for reliability evaluation and failure diagnosis are discussed, and current extensions of the environment and areas requiring further development are summarized.

The process of processing: exploring the validity of Neisser's perceptual cycle model with accounts from critical decision-making in the cockpit.

PubMed

Plant, Katherine L; Stanton, Neville A

2015-01-01

The perceptual cycle model (PCM) has been widely applied in ergonomics research in domains including road, rail and aviation. The PCM assumes that information processing occurs in a cyclical manner drawing on top-down and bottom-up influences to produce perceptual exploration and actions. However, the validity of the model has not been addressed. This paper explores the construct validity of the PCM in the context of aeronautical decision-making. The critical decision method was used to interview 20 helicopter pilots about critical decision-making. The data were qualitatively analysed using an established coding scheme, and composite PCMs for incident phases were constructed. It was found that the PCM provided a mutually exclusive and exhaustive classification of the information-processing cycles for dealing with critical incidents. However, a counter-cycle was also discovered which has been attributed to skill-based behaviour, characteristic of experts. The practical applications and future research questions are discussed. Practitioner Summary: This paper explores whether information processing, when dealing with critical incidents, occurs in the manner anticipated by the perceptual cycle model. In addition to the traditional processing cycle, a reciprocal counter-cycle was found. This research can be utilised by those who use the model as an accident analysis framework.

Fracture strength of three all-ceramic systems: Top-Ceram compared with IPS-Empress and In-Ceram.

PubMed

Quran, Firas Al; Haj-Ali, Reem

2012-03-01

The purpose of this study was to investigate the fracture loads and mode of failure of all-ceramic crowns fabricated using Top-Ceram and compare it with all-ceramic crowns fabricated from well-established systems: IPS-Empress II, In-Ceram. Thirty all-ceramic crowns were fabricated; 10 IPS-Empress II, 10 In-Ceram alumina and 10 Top-Ceram. Instron testing machine was used to measure the loads required to introduce fracture of each crown. Mean fracture load for In-Ceram alumina [941.8 (± 221.66) N] was significantly (p > 0.05) higher than those of Top-Ceram and IPS-Empress II. There was no statistically significant difference between Top-Ceram and IPS-Empress II mean fracture loads; 696.20 (+222.20) and 534 (+110.84) N respectively. Core fracture pattern was highest seen in Top- Ceram specimens.

On Variable Geometric Factor Systems for Top-Hat Electrostatic Space Plasma Analyzers

NASA Technical Reports Server (NTRS)

Kataria, Dhiren O.; Collinson, Glyn A.

2010-01-01

Even in the relatively small region of space that is the Earth's magnetosphere, ion and electron fluxes can vary by several orders of magnitude. Top-hat electrostatic analyzers currently do not possess the dynamic range required to sample plasma under all conditions. The purpose of this study was to compare, through computer simulation, three new electrostatic methods that would allow the sensitivity of a sensor to be varied through control of its geometric factor (GF) (much like an aperture on a camera). The methods studied were inner filter plates, split hemispherical analyzer (SHA) and top-cap electrode. This is the first discussion of the filter plate concept and also the first study where all three systems are studied within a common analyzer design, so that their relative merits could be fairly compared. Filter plates were found to have the important advantage that they facilitate the reduction in instrument sensitivity whilst keeping all other instrument parameters constant. However, it was discovered that filter plates have numerous disadvantages that make such a system impracticable for a top-hat electrostatic analyzer. It was found that both the top-cap electrode and SHA are promising variable geometric factor system (VGFS) concepts for implementation into a top-hat electrostatic analyzer, each with distinct advantages over the other.

Materials development and evaluation for the ceramic helical expander

DOE Office of Scientific and Technical Information (OSTI.GOV)

Landingham, R.L.; Taylor, R.W.

The supporting role of the materials program for the ceramic helical expander program is described. The materials problems for this rotory expander in an extremely severe environment-a direct coal-fired Brayton topping cycle is defined. Readily available materials and methods for possible solution to these material problems as well as initiating some longer-range studies to improve reliability were evaluated. A preliminary screening of materials in hot coal-fired environments to select candidate materials and coating was made. More detailed evaluations of these candidate materials-reaction-bonded silicon nitride (RBSN) and Si--Al--O--N (Sialon) system- and coatings-chemical-vapor-deposited silicon nitride (CVD-Si/sub 3/N/sub 4/) and CVD-Sialon need tomore » be performed. Termination of the helical expander program abruptly stopped the materials program during this evaluation.« less

Materials development and evaluation for the ceramic helical expander

DOE Office of Scientific and Technical Information (OSTI.GOV)

Landingham, R.L.; Taylor, R.W.

The supporting role of the materials program for the ceramic helical expander program is described. The materials problems for this rotory expander in an extremely severe environment - a direct coal-fired Brayton topping cycle is defined. Readily available materials and methods are evaluated for possible solution to these material problems as well as initiating some longer-range studies to improve reliability. A preliminary screening of materials in hot coal-fired environments to select candidate materials and coating, was made, but there is a need to perform more detailed evaluations of these candidate materials-reaction-bonded silicon nitride (RBSN) and Si--Al--O--N (Sialon) system- and coatings-chemical-vapor-depositedmore » silicon nitride (CVD-Si/sub 3/N/sub 4/) and CVD-Sialon. Termination of the helical expander program abruptly stopped the materials program during this evaluation.« less

Work function determination of promising electrode materials for thermionic energy converters

NASA Technical Reports Server (NTRS)

Jacobson, D.; Storms, E.; Skaggs, B.; Kouts, T.; Jaskie, J.; Manda, M.

1976-01-01

The work function determinations of candidate materials for low temperature (1400 K) thermionics through vacuum emission tests are discussed. Two systems, a vacuum emission test vehicle and a thermionic emission microscope are used for emission measurements. Some nickel and cobalt based super alloys were preliminarily examined. High temperature physical properties and corrosion behavior of some super alloy candidates are presented. The corrosion behavior of sodium is of particular interest since topping cycles might use sodium heat transfer loops. A Marchuk tube was designed for plasma discharge studies with the carbide and possibly some super alloy samples. A series of metal carbides and other alloys were fabricated and tested in a special high temperature mass spectrometer. This information coupled with work function determinations was evaluated in an attempt to learn how electron bonding occurs in transition alloys.

Hydraulic accumulator-compressor for geopressured enhanced oil recovery

DOEpatents

Goldsberry, Fred L.

1988-01-01

A hydraulic accumulator-compressor vessel using geothermal brine under pressure as a piston to compress waste (CO.sub.2 rich) gas is used in a system having a plurality of gas separators in tandem to recover pipeline quality gas from geothermal brine. A first high pressure separator feeds gas to a membrance separator which separates low pressure waste gas from high pressure quality gas. A second separator produces low pressure waste gas. Waste gas from both separators is combined and fed into the vessel through a port at the top as the vessel is drained for another compression cycle. High pressure brine is then admitted into the vessel through a port at the bottom of the vessel. Check valves control the flow of low pressure waste gas into the vessel and high pressure waste gas out of the vessel.

Probing and controlling terahertz-driven structural dynamics with surface sensitivity

DOE PAGES

Bowlan, Pamela Renee; Bowlan, J.; Trugman, S. A.; ...

2017-03-17

Intense, single-cycle terahertz (THz) pulses are powerful tools to understand and control material properties through low-energy resonances, such as phonons. Combining this with optical second harmonic generation (SHG) makes it possible to observe the resulting ultrafast structural changes with surface sensitivity. This makes SHG an ideal method to probe phonon dynamics in topological insulators (TI), materials with unique surface transport properties. Here, we resonantly excite a phonon mode in the TI Bi 2Se 3with THz pulses and use SHG to separate the resulting symmetry changes at the surface from the bulk. Furthermore, we coherently control the lattice vibrations with amore » pair of THz pulses. Lastly, our work demonstrates a versatile, table-top tool to probe and control phonon dynamics in a range of systems, particularly at surfaces and interfaces.« less

The roles of large top predators in coastal ecosystems: new insights from long term ecological research

USGS Publications Warehouse

Rosenblatt, Adam E.; Heithaus, Michael R.; Mather, Martha E.; Matich, Philip; Nifong, James C.; Ripple, William J.; Silliman, Brian R.

2013-01-01

During recent human history, human activities such as overhunting and habitat destruction have severely impacted many large top predator populations around the world. Studies from a variety of ecosystems show that loss or diminishment of top predator populations can have serious consequences for population and community dynamics and ecosystem stability. However, there are relatively few studies of the roles of large top predators in coastal ecosystems, so that we do not yet completely understand what could happen to coastal areas if large top predators are extirpated or significantly reduced in number. This lack of knowledge is surprising given that coastal areas around the globe are highly valued and densely populated by humans, and thus coastal large top predator populations frequently come into conflict with coastal human populations. This paper reviews what is known about the ecological roles of large top predators in coastal systems and presents a synthesis of recent work from three coastal eastern US Long Term Ecological Research (LTER) sites where long-term studies reveal what appear to be common themes relating to the roles of large top predators in coastal systems. We discuss three specific themes: (1) large top predators acting as mobile links between disparate habitats, (2) large top predators potentially affecting nutrient and biogeochemical dynamics through localized behaviors, and (3) individual specialization of large top predator behaviors. We also discuss how research within the LTER network has led to enhanced understanding of the ecological roles of coastal large top predators. Highlighting this work is intended to encourage further investigation of the roles of large top predators across diverse coastal aquatic habitats and to better inform researchers and ecosystem managers about the importance of large top predators for coastal ecosystem health and stability.

KENNEDY SPACE CENTER, FLA. - Crawler-transporter (CT) number 2 nears the launch pad with a Mobile Launcher Platform (MLP) on top. After recent modifications to the cab and muffler system, the CT was taken on a test run. The CT moves Space Shuttle vehicles, situated on the MLP, between the VAB and launch pad. Moving on four double-tracked crawlers, the CT uses a laser guidance system and a leveling system for the journey that keeps the top of a Space Shuttle vertical within plus- or minus-10 minutes of arc. The system enables the CT-MLP-Shuttle to negotiate the ramp leading to the launch pads and keep the load level. Unloaded, the CT weighs 6 million pounds. Seen on top of the MLP are two tail service masts that support the fluid, gas and electrical requirements of the orbiter’s liquid oxygen and liquid hydrogen aft umbilicals.

NASA Image and Video Library

2003-08-19

KENNEDY SPACE CENTER, FLA. - Crawler-transporter (CT) number 2 nears the launch pad with a Mobile Launcher Platform (MLP) on top. After recent modifications to the cab and muffler system, the CT was taken on a test run. The CT moves Space Shuttle vehicles, situated on the MLP, between the VAB and launch pad. Moving on four double-tracked crawlers, the CT uses a laser guidance system and a leveling system for the journey that keeps the top of a Space Shuttle vertical within plus- or minus-10 minutes of arc. The system enables the CT-MLP-Shuttle to negotiate the ramp leading to the launch pads and keep the load level. Unloaded, the CT weighs 6 million pounds. Seen on top of the MLP are two tail service masts that support the fluid, gas and electrical requirements of the orbiter’s liquid oxygen and liquid hydrogen aft umbilicals.

Core-top calibration of B/Ca in Pacific Ocean Neogloboquadrina incompta and Globigerina bulloides as a surface water carbonate system proxy

NASA Astrophysics Data System (ADS)

Quintana Krupinski, Nadine B.; Russell, Ann D.; Pak, Dorothy K.; Paytan, Adina

2017-05-01

Practical methods for reconstructing past ocean carbonate chemistry are needed to study past periods of ocean acidification and improve understanding of the marine carbonate system's role in the global climate cycles. Planktic foraminiferal B/Ca may fill this role, but requires better understanding and improved proxy calibrations. We used Pacific Ocean core-top sediments to generate new calibrations of the B/Ca proxy for past carbonate system parameters in two upwelling/subpolar species of asymbiotic planktic foraminifera (Globigerina bulloides and Neogloboquadrina incompta). Both species show significant positive correlation of B/Ca with calcite saturation (Ωcalcite) and carbonate ion concentration ([3 2-CO]) across a broad range of environmental conditions. This suggests a calcification rate control on B/Ca incorporation (as Ωcalcite regulates calcification rate), in agreement with recent inorganic calcite studies. This is also consistent with a surface entrapment model of trace element incorporation into CaCO3. In neither species is B/Ca significantly correlated with pH, suggesting that pH does not directly regulate boron incorporation, and that calculation of pH directly from foraminiferal B/Ca is not suitable. Correlations between B/Ca and [B(OH)4-], [B(OH)4-/HCO3-], and [B(OH)4-]/DIC) are weaker than with Ωcalcite. Boron partition coefficients (KD =[ B / Ca ] solid /[ B4 -(OH) /HCO-3 ] seawater) show little or no correlation with [CO32-] or temperature and vary widely, providing no support for application of KD to calculate carbonate system parameters from B/Ca. We also discuss potential effects of depth-related dissolution, temperature, and salinity on B/Ca. These empirical calibrations linking foraminiferal calcite B/Ca with Ωcalcite provide a strong tool for reconstructing the past ocean carbonate system and improve our understanding of the proxy's geochemical basis.

Quantitative controls on location and architecture of carbonate depositional sequences: Upper miocene, cabo de gata region, SE Spain

USGS Publications Warehouse

Franseen, E.K.; Goldstein, R.H.; Farr, M.R.

1997-01-01

Sequence stratigraphy, pinning-point relative sea-level curves, and magnetostratigraphy provide the quantitative data necessary to understand how rates of sea-level change and different substrate paleoslopes are dominant controls on accumulation rate, carbonate depositional sequence location, and internal architecture. Five third-order (1-10 my) and fourth-order (0.1-1.0 my) upper Miocene carbonate depositional sequences (DS1A, DS1B, DS2, DS3, TCC) formed with superimposed higher-frequency sea-level cycles in an archipelago setting in SE Spain. Overall, our study indicates when areas of high substrate slope (> 15??) are in shallow water, independent of climate, the location and internal architecture of carbonate deposits are not directly linked to sea-level position but, instead, are controlled by location of gently sloping substrates and processes of bypass. In contrast, if carbonate sediments are generated where substrates of low slope ( 15.6 cm/ky to ??? 2 cm/ky and overall relative sea level rose at rates of 17-21.4 cm/ky. Higher frequency sea-level rates were about 111 to more than 260 cm/ky, producing onlapping, fining- (deepening-) upward cycles. Decreasing accumulation rates resulted from decreasing surface area for shallow-water sediment production, drowning of shallow-water substrates, and complex sediment dispersal related to the archipelago setting. Typical systems tract and parasequence development should not be expected in "bypass ramp" settings; facies of onlapping strata do not track base level and are likely to be significantly different compared to onlapping strata associated with coastal onlap. Basal and upper DS2 reef megabreccias (indicating the transition from cool to warmer climatic conditions) were eroded from steep upslope positions and redeposited downslope onto areas of gentle substrate during rapid sea-level falls (> 22.7 cm/ky) of short duration. Such rapid sea-level falls and presence of steep slopes are not conducive to formation of forced regressive systems tracts composed of down-stepping reef clinoforms. The DS3 reefal platform formed where shallow water coincided with gently sloping substrates created by earlier deposition. Slow progradation (0.39-1.45 km/my) is best explained by the lack of an extensive bank top, progressively falling sea level, and low productivity resulting from siliciclastic debris and excess nutrients shed from nearby volcanic islands. Although DS3 strata were deposited during a third-order relative sea-level cycle, a typical transgressive systems tract is not recognizable, indicating that the initial relative rise in sea level was too rapid (??? 19 cm/ky). Downstepping reefs, forming a forced regressive systems tract, were deposited during the relative sea-level fall at the end of DS3, indicating that relatively slow rates of fall (10 cm/ky or less) over favorable paleoslope conditions are conducive to generation of forced regressive systems tracts consisting of downstepping reef clinoforms. The TCC sequence consists of four shallow-water sedimentary cycles that were deposited during a 400 ky to 100 ky time span. Such shallow-water cycles, typical of many platforms, form only where shallow water intersects gently sloping substrates. The relative thicknesses of cycles (< 2 m to 15 m thick), magnitudes of relative sea-level fluctuations associated with each cycle (25-30 m), high rates of relative sea-level fluctuations (minimum of 25-120 cm/ky), and the widespread distribution of similar TCC cycles in the Mediterranean and elsewhere are supportive of a glacio-eustatic

Quantitative controls on location and architecture of carbonate depositional sequences: upper miocene, cabo de gata region, se Spain

USGS Publications Warehouse

Franseen, E.K.; Goldstein, R.H.; Farr, M.R.

1998-01-01

Sequence stratigraphy, pinning-point relative sea-level curves, and magnetostratigraphy provide the quantitative data necessary to understand how rates of sea-level change and different substrate paleoslopes are dominant controls on accumulation rate, carbonate depositional sequence location, and internal architecture. Five third-order (1-10 my) and fourth-order (0.1-1.0 my) upper Miocene carbonate depositional sequences (DS1A, DS1B, DS2, DS3, TCC) formed with superimposed higher-frequency sea-level cycles in an archipelago setting in SE Spain. Overall, our study indicates when areas of high substrate slope (> 15??) are in shallow water, independent of climate, the location and internal architecture of carbonate deposits are not directly linked to sea-level position but, instead, are controlled by location of gently sloping substrates and processes of bypass. In contrast, if carbonate sediments are generated where substrates of low slope ( 15.6 cm/ky to ??? 2 cm/ky and overall relative sea level rose at rates of 17-21.4 cm/ky. Higher frequency sea-level rates were about 111 to more than 260 cm/ky, producing onlapping, fining- (deepening-) upward cycles. Decreasing accumulation rates resulted from decreasing surface area for shallow-water sediment production, drowning of shallow-water substrates, and complex sediment dispersal related to the archipelago setting. Typical systems tract and parasequence development should not be expected in "bypass ramp" settings; facies of onlapping strata do not track base level and are likely to be significantly different compared to onlapping strata associated with coastal onlap. Basal and upper DS2 reef megabreccias (indicating the transition from cool to warmer climatic conditions) were eroded from steep upslope positions and redeposited downslope onto areas of gentle substrate during rapid sea-level falls (> 22.7 cm/ky) of short duration. Such rapid sea-level falls and presence of steep slopes are not conducive to formation of forced regressive systems tracts composed of downstepping reef clinoforms. The DS3 reefal platform formed where shallow water coincided with gently sloping substrates created by earlier deposition. Slow progradation (0.39-1.45 km/my) is best explained by the lack of an extensive bank top, progressively falling sea level, and low productivity resulting from siliciclastic debris and excess nutrients shed from nearby volcanic islands. Although DS3 strata were deposited during a third-order relative sea-level cycle, a typical transgresse??e systems tract is not recognizable, indicating that the initial relative rise in sea level was too rapid (??? 19 cm/ky). Downstepping reefs, forming a forced regressive systems tract, were deposited during the relative sea-level fall at the end of DS3, indicating that relatively slow rates of fall (10 cm/ky or less) over favorable paleoslope conditions are conducive to generation of forced regressive systems tracts consisting of downstepping reef clinoforms. The TCC sequence consists of four shallow -water sedimentary cycles that were deposited during a 400 ky to 100 ky time span. Such shallow-water cycles, typical of many platforms, form only where shallow water intersects gently sloping substrates. The relative thicknesses of cycles (< 2 m to 15 m thick), magnitudes of relative sea-level fluctuations associated with each cycle (25-30 m), high rates of relative sea-level fluctuations (minimum of 25-120 cm/ky), and the widespread distribution of similar TCC cycles in the Mediterranean and elsewhere are supportive of a glacio-eustati

Degradation of thermal barrier coatings on an Integrated Gasification Combined Cycle (IGCC) simulated film-cooled turbine vane pressure surface due to particulate fly ash deposition

NASA Astrophysics Data System (ADS)

Luo, Kevin

Coal synthesis gas (syngas) can introduce contaminants into the flow of an Integrated Gasification Combined Cycle (IGCC) industrial gas turbine which can form molten deposits onto components of the first stage of a turbine. Research is being conducted at West Virginia University (WVU) to study the effects of particulate deposition on thermal barrier coatings (TBC) employed on the airfoils of an IGCC turbine hot section. WVU had been working with U.S. Department of Energy, National Energy Technology Laboratory (NETL) to simulate deposition on the pressure side of an IGCC turbine first stage vane to study the effects on film cooling. To simulate the particulate deposition, TBC coated, angled film-cooled test articles were subjected to accelerated deposition injected into the flow of a combustor facility with a pressure of approximately 4 atm and a gas temperature of 1560 K. The particle characteristics between engine conditions and laboratory are matched using the Stokes number and particulate loading. To investigate the degradation on the TBC from the particulate deposition, non-destructive evaluations were performed using a load-based multiple-partial unloading micro-indentation technique and were followed by scanning electron microscopy (SEM) evaluation and energy dispersive X-ray spectroscopy (EDS) examinations. The micro-indentation technique used in the study was developed by Kang et al. and can quantitatively evaluate the mechanical properties of materials. The indentation results found that the Young's Modulus of the ceramic top coat is higher in areas with deposition formation due to the penetration of the fly ash. The increase in the modulus of elasticity has been shown to result in a reduction of strain tolerance of the 7% yttria-stabilized zirconia (7YSZ) TBC coatings. The increase in the Young's modulus of the ceramic top coat is due to the stiffening of the YSZ columnar microstructure from the cooled particulate fly ash. SEM evaluation was used to evaluate the microstructure of the layers within the TBC system, and the SEM micrographs showed that the TBC/fly ash deposition interaction zone made the YSZ coating more susceptible to delamination and promoted a dissolution-reprecipitation mechanism that changes the YSZ morphology and composition. EDS examination provided elemental maps which showed a shallow infiltration depth of the fly ash deposits and an elemental distribution spectrum analysis showed yttria migration from the YSZ top coating into the molten deposition. This preliminary work should lead to future studies in gas turbine material coating systems and their interaction with simulated fly ash and potentially CMAS or volcanic ash deposition.

78 FR 54561 - Airworthiness Directives; Piper Aircraft, Inc. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-05

... for Lycoming and Piper Exhaust System Parts, for the entry ``tail pipe assembly, top'' in the third...-31-350, tail pipe assembly, top. This document corrects that error. In all other respects, the... exhaust system, expanding the inspection scope to include the entirety of each airplane exhaust system...

Soil carbon dynamics

NASA Astrophysics Data System (ADS)

Trumbore, Susan; Barbosa de Camargo, Plínio

The amount of organic carbon (C) stored in the upper meter of mineral soils in the Amazon Basin (˜40 Pg C) represents ˜3% of the estimated global store of soil carbon. Adding surface detrital C stocks and soil carbon deeper than 1 m can as much as quadruple this estimate. The potential for Amazon soil carbon to respond to changes in land use, climate, or atmospheric composition depends on the form and dynamics of soil carbon. Much (˜30% in the top ˜10 cm but >85% in soils to 1 m depth) of the carbon in mineral soils of the Oxisols and Ultisols that are the predominant soil types in the Amazon Basin is in forms that are strongly stabilized, with mean ages of centuries to thousands of years. Measurable changes in soil C stocks that accompany land use/land cover change occur in the upper meter of soil, although the presence of deep roots in forests systems drives an active C cycle at depths >1 m. Credible estimates of the potential for changes in Amazon soil C stocks with future land use and climate change are much smaller than predictions of aboveground biomass change. Soil organic matter influences fertility and other key soil properties, and thus is important independent of its role in the global C cycle. Most work on C dynamics is limited to upland soils, and more is needed to investigate C dynamics in poorly drained soils. Work is also needed to relate cycles of C with water, N, P, and other elements.

Genome-wide differential gene expression in immortalized DF-1 chicken embryo fibroblast cell line

PubMed Central

2011-01-01

Background When compared to primary chicken embryo fibroblast (CEF) cells, the immortal DF-1 CEF line exhibits enhanced growth rates and susceptibility to oxidative stress. Although genes responsible for cell cycle regulation and antioxidant functions have been identified, the genome-wide transcription profile of immortal DF-1 CEF cells has not been previously reported. Global gene expression in primary CEF and DF-1 cells was performed using a 4X44K chicken oligo microarray. Results A total of 3876 differentially expressed genes were identified with a 2 fold level cutoff that included 1706 up-regulated and 2170 down-regulated genes in DF-1 cells. Network and functional analyses using Ingenuity Pathways Analysis (IPA, Ingenuity® Systems, http://www.ingenuity.com) revealed that 902 of 3876 differentially expressed genes were classified into a number of functional groups including cellular growth and proliferation, cell cycle, cellular movement, cancer, genetic disorders, and cell death. Also, the top 5 gene networks with intermolecular connections were identified. Bioinformatic analyses suggested that DF-1 cells were characterized by enhanced molecular mechanisms for cell cycle progression and proliferation, suppressing cell death pathways, altered cellular morphogenesis, and accelerated capacity for molecule transport. Key molecules for these functions include E2F1, BRCA1, SRC, CASP3, and the peroxidases. Conclusions The global gene expression profiles provide insight into the cellular mechanisms that regulate the unique characteristics observed in immortal DF-1 CEF cells. PMID:22111699

Spacecube V2.0 Micro Single Board Computer

NASA Technical Reports Server (NTRS)

Petrick, David J. (Inventor); Geist, Alessandro (Inventor); Lin, Michael R. (Inventor); Crum, Gary R. (Inventor)

2017-01-01

A single board computer system radiation hardened for space flight includes a printed circuit board having a top side and bottom side; a reconfigurable field programmable gate array (FPGA) processor device disposed on the top side; a connector disposed on the top side; a plurality of peripheral components mounted on the bottom side; and wherein a size of the single board computer system is not greater than approximately 7 cm.times.7 cm.

Test Operations Procedure (TOP) 03-2-827 Test Procedures for Video Target Scoring Using Calibration Lights

DTIC Science & Technology

2016-04-04

Final 3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE Test Operations Procedure (TOP) 03-2-827 Test Procedures for Video Target Scoring Using...ABSTRACT This Test Operations Procedure (TOP) describes typical equipment and procedures to setup and operate a Video Target Scoring System (VTSS) to...lights. 15. SUBJECT TERMS Video Target Scoring System, VTSS, witness screens, camera, target screen, light pole 16. SECURITY

Propagation of flat-topped multi-Gaussian beams through a double-lens system with apertures.

PubMed

Gao, Yanqi; Zhu, Baoqiang; Liu, Daizhong; Lin, Zunqi

2009-07-20

A general model for different apertures and flat-topped laser beams based on the multi-Gaussian function is developed. The general analytical expression for the propagation of a flat-topped beam through a general double-lens system with apertures is derived using the above model. Then, the propagation characteristics of the flat-topped beam through a spatial filter are investigated by using a simplified analytical expression. Based on the Fluence beam contrast and the Fill factor, the influences of a pinhole size on the propagation of the flat-topped multi-Gaussian beam (FMGB) through the spatial filter are illustrated. An analytical expression for the propagation of the FMGB through the spatial filter with a misaligned pinhole is presented, and the influences of the pinhole offset are evaluated.

Evaluation of rheological parameters of the axial system using the Transfer Vibration through Spine (TVS) method.

PubMed

Panska, Sarka; Piglova, Tereza; Zeman, Josef; Marsik, Frantisek; Lopot, Frantisek; Jelen, Karel

2016-09-01

The human motion system reacts to both hypo and hyperactivity loads by changes to the rheological properties of tissues. This study deals with changes to the axial system (AS) compartment. Using the appropriate methodologies and mathematical-physical methods, these changes can be identified and quantified. This study describes the noninvasive TVS (Transfer Vibration through Spine) method, which was applied to assess the AS selected mechanical properties in various modes. A pilot study was conducted on a top-level twelve-year-old girl-gymnast. The data detection was carried out in three cycles, before and after a peak 3.5 hour training session and the next day, after resting, just before the next training. Specifically, the values of selected rheological parameters, the AS damping coefficient b and viscosity μ, were obtained. The dynamics of their changes, in the stated load cycles, has also been shown. The damping coefficient b fell from the value of 0.626 to 0.324 before training and increased to 0.394 after resting. The viscosity coefficient μ showed a similar trend, namely falling from the value of 9.85 [Pa.s] to 2.15 [Pa.s] and then increasing to 3.8 [Pa.s] . With its computational solution, the TVS method,is a diagnostic apparatus making it possible to classify AS properties, both quantitatively and qualitatively, or its chosen segments and their changes, respectively. It can be used in classifying, preventing and treating the consequences of extreme motion and relaxing modes. The TVS application also makes it possible to control AS states over therapeutic, recovery, ergonomic and other loading modes of the human locomotion system.

Constellation Program Life-cycle Cost Analysis Model (LCAM)

NASA Technical Reports Server (NTRS)

Prince, Andy; Rose, Heidi; Wood, James

2008-01-01

The Constellation Program (CxP) is NASA's effort to replace the Space Shuttle, return humans to the moon, and prepare for a human mission to Mars. The major elements of the Constellation Lunar sortie design reference mission architecture are shown. Unlike the Apollo Program of the 1960's, affordability is a major concern of United States policy makers and NASA management. To measure Constellation affordability, a total ownership cost life-cycle parametric cost estimating capability is required. This capability is being developed by the Constellation Systems Engineering and Integration (SE&I) Directorate, and is called the Lifecycle Cost Analysis Model (LCAM). The requirements for LCAM are based on the need to have a parametric estimating capability in order to do top-level program analysis, evaluate design alternatives, and explore options for future systems. By estimating the total cost of ownership within the context of the planned Constellation budget, LCAM can provide Program and NASA management with the cost data necessary to identify the most affordable alternatives. LCAM is also a key component of the Integrated Program Model (IPM), an SE&I developed capability that combines parametric sizing tools with cost, schedule, and risk models to perform program analysis. LCAM is used in the generation of cost estimates for system level trades and analyses. It draws upon the legacy of previous architecture level cost models, such as the Exploration Systems Mission Directorate (ESMD) Architecture Cost Model (ARCOM) developed for Simulation Based Acquisition (SBA), and ATLAS. LCAM is used to support requirements and design trade studies by calculating changes in cost relative to a baseline option cost. Estimated costs are generally low fidelity to accommodate available input data and available cost estimating relationships (CERs). LCAM is capable of interfacing with the Integrated Program Model to provide the cost estimating capability for that suite of tools.

Top Contributors to the School Psychology Literature: 1996-2005

ERIC Educational Resources Information Center

Roberts, Gabrielle A.; Davis, Kim S.; Zanger, Dinorah; Gerrard-Morris, Aimee; Robinson, Daniel H.

2006-01-01

S.G. Little (1997) reported the top contributors to the school psychology literature from 1987 to 1995. The present study represents a follow-up by examining the top contributors from 1996 to 2005. Similar to Little, a list of the top 50 contributors was developed using a point system that assigned more credit based on fewer coauthors and higher…

Top-down causation by information control: from a philosophical problem to a scientific research programme

PubMed Central

Auletta, G; Ellis, G.F.R; Jaeger, L

2008-01-01

It has been claimed that different types of causes must be considered in biological systems, including top-down as well as same-level and bottom-up causation, thus enabling the top levels to be causally efficacious in their own right. To clarify this issue, the important distinctions between information and signs are introduced here and the concepts of information control and functional equivalence classes in those systems are rigorously defined and used to characterize when top-down causation by feedback control happens, in a way that is testable. The causally significant elements we consider are equivalence classes of lower level processes, realized in biological systems through different operations having the same outcome within the context of information control and networks. PMID:18319208

40 CFR 63.7823 - What test methods and other procedures must I use to demonstrate initial compliance with the...

Code of Federal Regulations, 2012 CFR

2012-07-01

... subpart for BOPF shops: (1) For an existing BOPF shop: (i) Using a certified observer, determine the... consecutive observations recorded at 15-second intervals. (2) For a new BOPF shop housing a bottom-blown BOPF... average opacities for each steel production cycle. (3) For a new BOPF shop housing a top-blown BOPF: (i...

40 CFR 63.7823 - What test methods and other procedures must I use to demonstrate initial compliance with the...

Code of Federal Regulations, 2013 CFR

2013-07-01

... subpart for BOPF shops: (1) For an existing BOPF shop: (i) Using a certified observer, determine the... consecutive observations recorded at 15-second intervals. (2) For a new BOPF shop housing a bottom-blown BOPF... average opacities for each steel production cycle. (3) For a new BOPF shop housing a top-blown BOPF: (i...

40 CFR 63.7823 - What test methods and other procedures must I use to demonstrate initial compliance with the...

Code of Federal Regulations, 2014 CFR

2014-07-01

... subpart for BOPF shops: (1) For an existing BOPF shop: (i) Using a certified observer, determine the... consecutive observations recorded at 15-second intervals. (2) For a new BOPF shop housing a bottom-blown BOPF... average opacities for each steel production cycle. (3) For a new BOPF shop housing a top-blown BOPF: (i...

La Gocciolina (The Little Drop of Water).

ERIC Educational Resources Information Center

Palandra, Maria

This primary level reader in Italian intended for use in a bilingual education setting, is about the life cycle of a drop of water. The drop of water is personified and the story tells of its adventures as it travels from the top of the lake to the bottom, its meeting with the inhabitants of the lake, and its trip to the clouds. After deciding not…

[Discussion on research thinking of traditional Chinese medicine standardization system based on whole process quality control].

PubMed

Dong, Ling; Sun, Yu; Pei, Wen-Xuan; Dai, Jun-Dong; Wang, Zi-Yu; Pan, Meng; Chen, Jiang-Peng; Wang, Yun

2017-12-01

The concept of "Quality by design" indicates that good design for the whole life cycle of pharmaceutical production enables the drug to meet the expected quality requirements. Aiming at the existing problems of the traditional Chinese medicine (TCM) industry, the TCM standardization system was put forward in this paper from the national strategic level, under the guidance by the idea of quality control in international manufacturing industry and with considerations of TCM industry's own characteristics and development status. The connotation of this strategy was to establish five interrelated systems: multi-indicators system based on tri-indicators system, quality standard and specification system of TCM herbal materials and decoction pieces, quality traceability system, data monitoring system based on whole-process quality control, and whole-process quality management system of TCM, and achieve the whole process systematic and scientific study in TCM industry through "top-level design-implement in steps-system integration" workflow. This article analyzed the correlation between the quality standards of all links, established standard operating procedures of each link and whole process, and constructed a high standard overall quality management system for TCM industry chains, in order to provide a demonstration for the establishment of TCM whole-process quality control system and provide systematic reference and basis for standardization strategy in TCM industry. Copyright© by the Chinese Pharmaceutical Association.

The combined effects of eustasy, tectonism, and clastic influx on the development of Pennsylvanian cyclic carbonates, southern Sangre de Cristo Mountains, New Mexico

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gong Shouyeh; Humphrey, J.D.

1991-03-01

Pennsylvania cyclothems are well documented on stable continental shelves and the cyclicity has generally been attributed to glacio-eustasy. As a contrast, Atokan-Desmoinesian cyclic carbonates of the southern Sangre de Cristo Mountains developed in a tectonically active foreland basin, formed by thrusting along the Picuris-Pecos fault during early Pennsylvanian time. Strata exposed in two sections (Dalton Bluff, 260 m; Johnson Mesa, 340 m) are characterized by (1) shallowing-upward cycles, (2) cycles of variable thickness (5-20 m), (3) incomplete cycles, (4) cycles interrupted by terrigenous clastic input, and (5) noncyclic intervals. Allocyclic mechanisms alone cannot fully explain these observations; the authors hereinmore » propose that a complex interplay among eustasy, tectonism, and clastic sediment supply were responsible for the observed cycles. Lithofacies analysis indicates that location within the foreland basin played a significant role in cycle attributes. In the deeper portions of the basin (e.g., Dalton Bluff), an idealized cycle, from base to top consists of (1) shale/marl facies, (2) brachiopod wackestone facies, (3) phylloid algal facies, and (4) marine clastic facies. No evidence for subaerial exposure of cycle caps is noted. In contrast, in shallow portions of the basin near the forebulge (e.g., Johnson Mesa) the marine clastic facies is substituted by crinoidal grainstone/packstone facies that is capped by subaerial exposure surface. Each of the two cycles displays an overall grand (lower order) shallowing-upward cycle. This grand cycle developed as sediments infilled the initially starved foreland basin.« less

A novel thermal management system for improving discharge/charge performance of Li-ion battery packs under abuse

NASA Astrophysics Data System (ADS)

Arora, Shashank; Kapoor, Ajay; Shen, Weixiang

2018-02-01

Parasitic load, which describes electrical energy consumed by battery thermal management system (TMS), is an important design criterion for battery packs. Passive TMSs using phase change materials (PCMs) are thus generating much interest. However, PCMs suffer from low thermal conductivities. Most current thermal conductivity enhancement techniques involve addition of foreign particles to PCMs. Adding foreign particles increases effective thermal conductivity of PCM-systems but at expense of their latent heat capacity. This paper presents an alternate approach for improving thermal performance of PCM-based TMSs. The introduced technique involves placing battery cells in a vertically inverted position within the battery-pack. It is demonstrated through experiments that inverted cell-layout facilitates build-up of convection current in the pack, which in turn minimises thermal variations within the PCM matrix by enabling PCM mass transfer between the top and the bottom regions of the battery pack. The proposed system is found capable of maintaining tight control over battery cell temperature even during abusive usage, defined as high-rate repetitive cycling with minimal rest periods. In addition, this novel TMS can recover waste heat from PCM-matrix through thermoelectric devices, thereby resulting in a negative parasitic load for TMS.

NPRL-Z-1, as a new topoisomerase II poison, induces cell apoptosis and ROS generation in human renal carcinoma cells.

PubMed

Wu, Szu-Ying; Pan, Shiow-Lin; Xiao, Zhi-Yan; Hsu, Jui-Ling; Chen, Mei-Chuan; Lee, Kuo-Hsiung; Teng, Che-Ming

2014-01-01

NPRL-Z-1 is a 4β-[(4"-benzamido)-amino]-4'-O-demethyl-epipodophyllotoxin derivative. Previous reports have shown that NPRL-Z-1 possesses anticancer activity. Here NPRL-Z-1 displayed cytotoxic effects against four human cancer cell lines (HCT 116, A549, ACHN, and A498) and exhibited potent activity in A498 human renal carcinoma cells, with an IC50 value of 2.38 µM via the MTT assay. We also found that NPRL-Z-1 induced cell cycle arrest in G1-phase and detected DNA double-strand breaks in A498 cells. NPRL-Z-1 induced ataxia telangiectasia-mutated (ATM) protein kinase phosphorylation at serine 1981, leading to the activation of DNA damage signaling pathways, including Chk2, histone H2AX, and p53/p21. By ICE assay, the data suggested that NPRL-Z-1 acted on and stabilized the topoisomerase II (TOP2)-DNA complex, leading to TOP2cc formation. NPRL-Z-1-induced DNA damage signaling and apoptotic death was also reversed by TOP2α or TOP2β knockdown. In addition, NPRL-Z-1 inhibited the Akt signaling pathway and induced reactive oxygen species (ROS) generation. These results demonstrated that NPRL-Z-1 appeared to be a novel TOP2 poison and ROS generator. Thus, NPRL-Z-1 may present a significant potential anticancer candidate against renal carcinoma.

Sex Difference in Draft-Legal Ultra-Distance Events - A Comparison between Ultra-Swimming and Ultra-Cycling.

PubMed

Salihu, Lejla; Rüst, Christoph Alexander; Rosemann, Thomas; Knechtle, Beat

2016-04-30

Recent studies reported that the sex difference in performance in ultra-endurance sports such as swimming and cycling changed over the years. However, the aspect of drafting in draft-legal ultra-endurance races has not yet been investigated. This study investigates the sex difference in ultra-swimming and ultra-cycling draft-legal races where drafting - swimming or cycling behind other participants to save energy and have more power at the end of the race to overtake them, is allowed. The change in performance of the annual best and the annual three best in an ultra-endurance swimming race (16-km 'Faros Swim Marathon') over 38 years and in a 24-h ultra-cycling race ('World Cycling Race') over 13 years were compared and analysed with respect to sex difference. Furthermore, performances of the fastest female and male finishers ever were compared. In the swimming event, the sex difference of the annual best male and female decreased non-significantly (P = 0.262) from 5.3% (1976) to 1.0% (2013). The sex gap of speed in the annual three fastest swimmers decreased significantly (P = 0.043) from 5.9 ± 1.6% (1979) to 4.7 ± 3.1% (2013). In the cycling event, the difference in cycling speed between the annual best male and female decreased significantly (P = 0.026) from 33.31% (1999) to 10.89% (2011). The sex gap of speed in the annual three fastest decreased significantly (P = 0.001) from 32.9 ± 0.6% (1999) to 16.4 ± 5.9% (2011). The fastest male swimmer ever (swimming speed 5.3 km/h, race time: 03:01:55 h:min:s) was 1.5% faster than the fastest female swimmer (swimming speed 5.2 km/h, race time: 03:04:09 h:min:s). The three fastest male swimmers ever (mean 5.27 ± 0.13 km/h) were 4.4% faster than the three fastest female swimmers (mean 5.05 ± 0.20 km/h) (P < 0.05). In the cycling event, the best male ever (cycling speed 45.8 km/h) was 26.4% faster than the best female (cycling speed 36.1 km/h). The three fastest male cyclists ever (45.9 km/h) (mean 45.85 ± 0.05 km/h) were 32.1% faster (P < 0.05) than the three fastest female cyclists ever (34.7 km/h) (mean 34.70 ± 1.87 km/h). In summary, in draft-legal ultra-distance events such as swimming and cycling, the sex difference in the annual top and annual top three swimmers and cyclists decreased (i.e. non-linearly in swimmers and linearly in cyclists) over the years. The sex difference of the fastest athletes ever was smaller in swimming (1.5%) than in cycling (26.4%). This finding is different from reports about races where drafting was not possible or even prohibited and where the sex difference remained stable over years.

Candidate genes and pathogenesis investigation for sepsis-related acute respiratory distress syndrome based on gene expression profile.

PubMed

Wang, Min; Yan, Jingjun; He, Xingxing; Zhong, Qiang; Zhan, Chengye; Li, Shusheng

2016-04-18

Acute respiratory distress syndrome (ARDS) is a potentially devastating form of acute inflammatory lung injury as well as a major cause of acute respiratory failure. Although researchers have made significant progresses in elucidating the pathophysiology of this complex syndrome over the years, the absence of a universal detail disease mechanism up until now has led to a series of practical problems for a definitive treatment. This study aimed to predict some genes or pathways associated with sepsis-related ARDS based on a public microarray dataset and to further explore the molecular mechanism of ARDS. A total of 122 up-regulated DEGs and 91 down-regulated differentially expressed genes (DEGs) were obtained. The up- and down-regulated DEGs were mainly involved in functions like mitotic cell cycle and pathway like cell cycle. Protein-protein interaction network of ARDS analysis revealed 20 hub genes including cyclin B1 (CCNB1), cyclin B2 (CCNB2) and topoisomerase II alpha (TOP2A). A total of seven transcription factors including forkhead box protein M1 (FOXM1) and 30 target genes were revealed in the transcription factor-target gene regulation network. Furthermore, co-cited genes including CCNB2-CCNB1 were revealed in literature mining for the relations ARDS related genes. Pathways like mitotic cell cycle were closed related with the development of ARDS. Genes including CCNB1, CCNB2 and TOP2A, as well as transcription factors like FOXM1 might be used as the novel gene therapy targets for sepsis related ARDS.

Effects of the interception of litterfall by the understory on carbon cycling in eucalyptus plantations of South China.

PubMed

Yang, Long; Wang, Jun; Huang, Yuhui; Hui, Dafeng; Wen, Meili

2014-01-01

For the purposes of forest restoration, carbon (C) fixation, and economic improvement, eucalyptus (Eucalyptus urophylla) has been widely planted in South China. The understory of eucalyptus plantations is often occupied by a dense community of the fern Dicranopteris dichotoma, which intercepts tree canopy leaf litter before it reaches the ground. To understand the effects of this interception of litterfall on C cycling in eucalyptus plantations, we quantified the mass of intercepted litter and the influences of litterfall interception on litter decomposition and soil respiration. The total mass of E. urophylla litterfall collected on the understory was similar to that collected by the traditional litter trap method. All of the eucalyptus litterfall is intercepted by the D. dichotoma canopy. Of the litterfall that was intercepted by D. dichotoma, 20-40% and 60-80% was intercepted by the top (50-100 cm) and bottom (0-50 cm) of the understory canopy, respectively. Intercepted litterfall decomposed faster at the bottom of understory canopy (at the base of the plants) than at the top, and decomposition was slower on the soil surface in the absence of understory than on any location in the understory canopy. Soil respiration was highest when both the understory and litter were present and was lowest when both the understory and litter were absent. These results indicate that litterfall interception changed carbon flow between aboveground and belowground through litter decomposition and soil respiration, which changed carbon cycling in eucalyptus plantations. The effects of the understory on litter decomposition and soil respiration should be considered in ecosystem carbon models.

Heterogeneous Concurrent Modeling and Design in Java (Volume 1: Introduction to Ptolemy II)

DTIC Science & Technology

2008-04-01

Code 79 2.8.4. Lifecycle Management Actors 79 2.9. Domains 80 2.9.1. SDF and Multirate Systems 81 2.9.2. Data-Dependent Rates 82 2.9.3. Discrete-Event...and we added modeling capabilities for wireless systems. We also introduced lifecycle management actors and dynamically evaluated higher-order...top.setName( "DiningPhilosophers"); Manager manager = new Manager (" Manager "); top.setManager( manager ); new CSPDirector(top

Biospheric Monitoring and Ecological Forecasting using EOS/MODIS data, ecosystem modeling, planning and scheduling technologies

NASA Astrophysics Data System (ADS)

Nemani, R. R.; Votava, P.; Golden, K.; Hashimoto, H.; Jolly, M.; White, M.; Running, S.; Coughlan, J.

2003-12-01

The latest generation of NASA Earth Observing System satellites has brought a new dimension to continuous monitoring of the living part of the Earth System, the Biosphere. EOS data can now provide weekly global measures of vegetation productivity and ocean chlorophyll, and many related biophysical factors such as land cover changes or snowmelt rates. However, information with the highest economic value would be forecasting impending conditions of the biosphere that would allow advanced decision-making to mitigate dangers, or exploit positive trends. We have developed a software system called the Terrestrial Observation and Prediction System (TOPS) to facilitate rapid analysis of ecosystem states/functions by integrating EOS data with ecosystem models, surface weather observations and weather/climate forecasts. Land products from MODIS (Moderate Resolution Imaging Spectroradiometer) including land cover, albedo, snow, surface temperature, leaf area index are ingested into TOPS for parameterization of models and for verifying model outputs such as snow cover and vegetation phenology. TOPS is programmed to gather data from observing networks such as USDA soil moisture, AMERIFLUX, SNOWTEL to further enhance model predictions. Key technologies enabling TOPS implementation include the ability to understand and process heterogeneous-distributed data sets, automated planning and execution of ecosystem models, causation analysis for understanding model outputs. Current TOPS implementations at local (vineyard) to global scales (global net primary production) can be found at http://www.ntsg.umt.edu/tops.

Development of an Open Rotor Cycle Model in NPSS Using a Multi-Design Point Approach

NASA Technical Reports Server (NTRS)

Hendricks, Eric S.

2011-01-01

NASA's Environmentally Responsible Aviation Project and Subsonic Fixed Wing Project are focused on developing concepts and technologies which may enable dramatic reductions to the environmental impact of future generation subsonic aircraft (Refs. 1 and 2). The open rotor concept (also referred to as the Unducted Fan or advanced turboprop) may allow the achievement of this objective by reducing engine emissions and fuel consumption. To evaluate its potential impact, an open rotor cycle modeling capability is needed. This paper presents the initial development of an open rotor cycle model in the Numerical Propulsion System Simulation (NPSS) computer program which can then be used to evaluate the potential benefit of this engine. The development of this open rotor model necessitated addressing two modeling needs within NPSS. First, a method for evaluating the performance of counter-rotating propellers was needed. Therefore, a new counter-rotating propeller NPSS component was created. This component uses propeller performance maps developed from historic counter-rotating propeller experiments to determine the thrust delivered and power required. Second, several methods for modeling a counter-rotating power turbine within NPSS were explored. These techniques used several combinations of turbine components within NPSS to provide the necessary power to the propellers. Ultimately, a single turbine component with a conventional turbine map was selected. Using these modeling enhancements, an open rotor cycle model was developed in NPSS using a multi-design point approach. The multi-design point (MDP) approach improves the engine cycle analysis process by making it easier to properly size the engine to meet a variety of thrust targets throughout the flight envelope. A number of design points are considered including an aerodynamic design point, sea-level static, takeoff and top of climb. The development of this MDP model was also enabled by the selection of a simple power management scheme which schedules propeller blade angles with the freestream Mach number. Finally, sample open rotor performance results and areas for further model improvements are presented.

Early Diagenesis of Trace Elements in Modern Fjord Sediments of the High Arctic

NASA Astrophysics Data System (ADS)

Herbert, L.; Riedinger, N.; Aller, R. C.; Jørgensen, B. B.; Wehrmann, L.

2017-12-01

Marine sediments are critical repositories for elements that are only available at trace concentrations in seawater, such as Fe, Mn, Co, Ni, As, Mo, and U. The behavior of these trace elements in the sediment is governed by a dynamic interplay of diagenetic reactions involving organic carbon, Fe and Mn oxides, and sulfur phases. In the Arctic fjords of Svalbard, glacial meltwater delivers large amounts of reactive Fe and Mn oxides to the sediment, while organic carbon is deposited episodically and diluted by lithogenic material. These conditions result in pronounced Fe and Mn cycling, which in turn drives other diagenetic processes such as rapid sulfide oxidation. These conditions make the Svalbard fjords ideal sites for investigating trace element diagenesis because they allow resolution of the interconnections between Fe and Mn dynamics and trace element cycling. In August 2016, we collected sediment cores from three Svalbard fjords and analyzed trace elements in the pore water and solid sediment over the top meter. Initial results reveal the dynamic nature of these fjords, which are dominated by non-steady state processes and episodic events such as meltwater pulses and phytoplankton blooms. Within this system, the distribution of As appears to be strongly linked to the Fe cycle, while Co and Ni follow Mn; thus, these three elements may be released from the sediment through diffusion and bioturbation along with Fe and Mn. The pore water profiles of U and Mo indicate removal processes that are independent from Fe or Mn, and which are rather unexpected given the apparent diagenetic conditions. Our results will help elucidate the processes controlling trace element cycling in a dynamic, glacially impacted environment and will ultimately contribute to our understanding of the role of fjords in the biogeochemical cycling of trace elements in a rapidly changing Arctic Ocean.

Top-down models in biology: explanation and control of complex living systems above the molecular level.

PubMed

Pezzulo, Giovanni; Levin, Michael

2016-11-01

It is widely assumed in developmental biology and bioengineering that optimal understanding and control of complex living systems follows from models of molecular events. The success of reductionism has overshadowed attempts at top-down models and control policies in biological systems. However, other fields, including physics, engineering and neuroscience, have successfully used the explanations and models at higher levels of organization, including least-action principles in physics and control-theoretic models in computational neuroscience. Exploiting the dynamic regulation of pattern formation in embryogenesis and regeneration requires new approaches to understand how cells cooperate towards large-scale anatomical goal states. Here, we argue that top-down models of pattern homeostasis serve as proof of principle for extending the current paradigm beyond emergence and molecule-level rules. We define top-down control in a biological context, discuss the examples of how cognitive neuroscience and physics exploit these strategies, and illustrate areas in which they may offer significant advantages as complements to the mainstream paradigm. By targeting system controls at multiple levels of organization and demystifying goal-directed (cybernetic) processes, top-down strategies represent a roadmap for using the deep insights of other fields for transformative advances in regenerative medicine and systems bioengineering. © 2016 The Author(s).

Top-down models in biology: explanation and control of complex living systems above the molecular level

PubMed Central

2016-01-01

It is widely assumed in developmental biology and bioengineering that optimal understanding and control of complex living systems follows from models of molecular events. The success of reductionism has overshadowed attempts at top-down models and control policies in biological systems. However, other fields, including physics, engineering and neuroscience, have successfully used the explanations and models at higher levels of organization, including least-action principles in physics and control-theoretic models in computational neuroscience. Exploiting the dynamic regulation of pattern formation in embryogenesis and regeneration requires new approaches to understand how cells cooperate towards large-scale anatomical goal states. Here, we argue that top-down models of pattern homeostasis serve as proof of principle for extending the current paradigm beyond emergence and molecule-level rules. We define top-down control in a biological context, discuss the examples of how cognitive neuroscience and physics exploit these strategies, and illustrate areas in which they may offer significant advantages as complements to the mainstream paradigm. By targeting system controls at multiple levels of organization and demystifying goal-directed (cybernetic) processes, top-down strategies represent a roadmap for using the deep insights of other fields for transformative advances in regenerative medicine and systems bioengineering. PMID:27807271

Knowledge-Based Aircraft Automation: Managers Guide on the use of Artificial Intelligence for Aircraft Automation and Verification and Validation Approach for a Neural-Based Flight Controller

NASA Technical Reports Server (NTRS)

Broderick, Ron

1997-01-01

The ultimate goal of this report was to integrate the powerful tools of artificial intelligence into the traditional process of software development. To maintain the US aerospace competitive advantage, traditional aerospace and software engineers need to more easily incorporate the technology of artificial intelligence into the advanced aerospace systems being designed today. The future goal was to transition artificial intelligence from an emerging technology to a standard technology that is considered early in the life cycle process to develop state-of-the-art aircraft automation systems. This report addressed the future goal in two ways. First, it provided a matrix that identified typical aircraft automation applications conducive to various artificial intelligence methods. The purpose of this matrix was to provide top-level guidance to managers contemplating the possible use of artificial intelligence in the development of aircraft automation. Second, the report provided a methodology to formally evaluate neural networks as part of the traditional process of software development. The matrix was developed by organizing the discipline of artificial intelligence into the following six methods: logical, object representation-based, distributed, uncertainty management, temporal and neurocomputing. Next, a study of existing aircraft automation applications that have been conducive to artificial intelligence implementation resulted in the following five categories: pilot-vehicle interface, system status and diagnosis, situation assessment, automatic flight planning, and aircraft flight control. The resulting matrix provided management guidance to understand artificial intelligence as it applied to aircraft automation. The approach taken to develop a methodology to formally evaluate neural networks as part of the software engineering life cycle was to start with the existing software quality assurance standards and to change these standards to include neural network development. The changes were to include evaluation tools that can be applied to neural networks at each phase of the software engineering life cycle. The result was a formal evaluation approach to increase the product quality of systems that use neural networks for their implementation.

Temporal variation of the cloud top height over the tropical Pacific observed by geostationary satellites

NASA Astrophysics Data System (ADS)

Nishi, N.; Hamada, A.

2012-12-01

Stratiform clouds (nimbostratus and cirriform clouds) in the upper troposphere accompanied with cumulonimbus activity cover large part of the tropical region and largely affect the radiation and water vapor budgets there. Recently new satellites (CloudSat and CALIPSO) can give us the information of cloud height and cloud ice amount even over the open ocean. However, their coverage is limited just below the satellite paths; it is difficult to capture the whole shape and to trace the lifecycle of each cloud system by using just these datasets. We made, as a complementary product, a dataset of cloud top height and visible optical thickness with one-hour resolution over the wide region, by using infrared split-window data of the geostationary satellites (AGU fall meeting 2011) and released on the internet (http://database.rish.kyoto-u.ac.jp/arch/ctop/). We made lookup tables for estimating cloud top height only with geostationary infrared observations by comparing them with the direct cloud observation by CloudSat (Hamada and Nishi, 2010, JAMC). We picked out the same-time observations by MTSAT and CloudSat and regressed the cloud top height observation of CloudSat back onto 11μm brightness temperature (Tb) and the difference between the 11μm Tb and 12μm Tb. We will call our estimated cloud top height as "CTOP" below. The area of our coverage is 85E-155W (MTSAT2) and 80E-160W(MTSAT1R), and 20S-20N. The accuracy of the estimation with the IR split-window observation is the best in the upper tropospheric height range. We analyzed the formation and maintenance of the cloud systems whose top height is in the upper troposphere with our CTOP analysis, CloudSat 2B-GEOPROF, and GSMaP (Global Satellite Mapping of Precipitation) precipitation data. Most of the upper tropospheric stratiform clouds have their cloud top within 13-15 km range. The cloud top height decreases slowly when dissipating but still has high value to the end. However, we sometimes observe that a little lower cloud top height (6-10 km) is kept within one-two days. A typical example is observed on 5 January 2011 in a dissipating cloud system with 1000-km scale. This cluster located between 0-10N just west of the International Date Line and moved westward with keeping relatively lower cloud top (6-10 km) over one day. This top height is lower than the ubiquitous upper-tropospheric stratiform clouds but higher than the so-called 'congestus cloud' whose top height is around 0C. CloudSat data show the presence of convective rainfall. It suggests that this cloud system continuously kept making new anvil clouds in a little lower height than usual. We examined the seasonal variation of the distribution of cloud systems with a little lower cloud top height (6-11 km) during 2010-11. The number of such cloud systems is not constant with seasons but frequently increased in some specific seasons. Over the equatorial ocean region (east of 150E), they were frequently observed during the northern winter.

Bottom-up processes drive reproductive success in an apex predator.

PubMed

Schmidt, Joshua H; McIntyre, Carol L; Roland, Carl A; MacCluskie, Margaret C; Flamme, Melanie J

2018-02-01

One of the central goals of the field of population ecology is to identify the drivers of population dynamics, particularly in the context of predator-prey relationships. Understanding the relative role of top-down versus bottom-up drivers is of particular interest in understanding ecosystem dynamics. Our goal was to explore predator-prey relationships in a boreal ecosystem in interior Alaska through the use of multispecies long-term monitoring data. We used 29 years of field data and a dynamic multistate site occupancy modeling approach to explore the trophic relationships between an apex predator, the golden eagle, and cyclic populations of the two primary prey species available to eagles early in the breeding season, snowshoe hare and willow ptarmigan. We found that golden eagle reproductive success was reliant on prey numbers, but also responded prior to changes in the phase of the snowshoe hare population cycle and failed to respond to variation in hare cycle amplitude. There was no lagged response to ptarmigan populations, and ptarmigan populations recovered quickly from the low phase. Together, these results suggested that eagle reproduction is largely driven by bottom-up processes, with little evidence of top-down control of either ptarmigan or hare populations. Although the relationship between golden eagle reproductive success and prey abundance had been previously established, here we established prey populations are likely driving eagle dynamics through bottom-up processes. The key to this insight was our focus on golden eagle reproductive parameters rather than overall abundance. Although our inference is limited to the golden eagle-hare-ptarmigan relationships we studied, our results suggest caution in interpreting predator-prey abundance patterns among other species as strong evidence for top-down control.

Acoustic emission and fatigue damage induced in plasma-sprayed hydroxyapatite coating layers.

PubMed

Laonapakul, Teerawat; Otsuka, Yuichi; Nimkerdphol, Achariya Rakngarm; Mutoh, Yoshiharu

2012-04-01

In order to improve the adhesive strength of hydroxyapatite (HAp) coatings, grit blasting with Al(2)O(3) powder and then wet blasting with HAp/Ti mixed powders was carried out on a commercially pure Ti (cp-Ti) substrate. Subsequently, an HAp/Ti bond coat layer and HAp top coat layer were deposited by plasma spraying. Fatigue tests of the HAp-coated specimens were carried out under four-point bending. Acoustic emission (AE) signals during the entire fatigue test were monitored to investigate the fatigue cracking behavior of the HAp-coated specimens. The HAp-coated specimens could survive up to 10(7) cycles without spallation of the HAp coating layers at the stress amplitude of 120 MPa. The HAp-coated specimens without HAp/Ti bond coat layer showed shorter fatigue life and easy crack nucleation compared to the HAp-coated specimens with HAp/Ti bond coat layer. The delamination and spallation of the HAp top coat with HAp/Ti bond coat on cp-Ti was not observed until the crack propagated into the cp-Ti during the final fracture stage of the fatigue cycle. Therefore, the HAp/Ti bond coat layer was found to greatly improve the fatigue damage resistance of the HAp coating layer. Three stages of the fatigue failure behavior of the HAp top coat with HAp/Ti bond coat on a cp-Ti substrate can be clearly estimated by the AE monitoring technique. These stages are cracks nucleating and propagating in the coating layer, cracks propagating in the substrate, and cracks propagating unstably to final fracture. Copyright © 2011 Elsevier Ltd. All rights reserved.

Adjuvant docetaxel and cyclophosphamide plus trastuzumab in patients with HER2-amplified early stage breast cancer: a single-group, open-label, phase 2 study.

PubMed

Jones, Stephen E; Collea, Rufus; Paul, Devchand; Sedlacek, Scot; Favret, Anne M; Gore, Ira; Lindquist, Deborah L; Holmes, Frankie Ann; Allison, Mary Ann K; Brooks, Barry D; Portillo, Raul M; Vukelja, Svetislava J; Steinberg, Michael S; Stokoe, Christopher; Crockett, Maria W; Wang, Yunfei; Asmar, Lina; Robert, Nicholas J; O'Shaughnessy, Joyce

2013-10-01

Previous results suggest that docetaxel plus cyclophosphamide improves disease-free survival (DFS) and overall survival compared with doxorubicin plus cyclophosphamide in early stage breast cancer. We assessed the addition of 1 year of trastuzumab to a non-anthracycline regimen, docetaxel plus cyclophosphamide, in patients with HER2-amplified early stage breast cancer and examined whether this regimen was equally effective in patients with TOP2A-amplified and TOP2A-non-amplified disease. This was an open-label, single-group, phase 2 study. Eligible patients were aged 18-75 years; had Eastern Cooperative Oncology Group performance status of 1 or less; HER2-amplified early stage breast cancer; operable, histologically confirmed, invasive carcinoma of the breast; adequate tumour specimen available for FISH analysis of TOP2A status; and adequate haematological, renal, hepatic, and cardiac function. Patients received four 21-day cycles of intravenous docetaxel 75 mg/m(2), plus intravenous cyclophosphamide 600 mg/m(2), plus intravenous trastuzumab 4 mg/kg (loading dose) on day 1 and 2 mg/kg on days 1, 8, and 15 during chemotherapy, followed by trastuzumab 6 mg/kg every three weeks for the remainder of 1 year. The primary endpoint was 2-year DFS in TOP2A-amplified and TOP2A-non-amplified patients; the primary analysis was done by intention to treat. This study is registered with ClinicalTrials.gov, number NCT00493649. 493 patients were enrolled between June 15, 2007, and Aug 5, 2009. After a median follow-up of 36·1 months (IQR 35·5-36·7), 2-year DFS was 97·8% (95% CI 94·2-99·2) and 2-year overall survival was 99·5% (95% CI 96·2-99·9) for the 190 patients with TOP2A-amplified disease; 2-year DFS was 97·9% (95% CI 94·9-99·1) and 2-year overall survival was 98·8% (95% CI 96·2-99·6) for the 248 patients with TOP2A-non-amplified disease; 55 patients were not assessable for TOP2A status. In the 486 patients who received at least one dose of study drug, the most common adverse events of any grade were fatigue (284 patients, 58·4%), neutropenia (250, 51·4%), and nausea (217, 44·7%). The most common grade 3-4 toxic effects were neutropenia (229, 47·1%), febrile neutropenia (30, 6·2%), fatigue (21, 4·3%), and diarrhoea (16, 3·3%). Cardiac dysfunction occurred in 29 (6·0%) patients (12 [2·5%] grade 1, 15 [3·1%] grade 2, and two [0·4%] grade 3). 23 patients had at least one study-related serious adverse event. 16 patients stopped trastuzumab because of cardiac dysfunction. A short, four-cycle regimen of docetaxel and cyclophosphamide combined with trastuzumab could be an option for adjuvant treatment of women with lower risk HER2-amplified early breast cancer, irrespective of TOP2A status. Sanofi. Copyright © 2013 Elsevier Ltd. All rights reserved.

CVISN guide to top-level design : preliminary version P1.1

DOT National Transportation Integrated Search

1999-06-25

The CVISN (Commercial Vehicle Information Systems and Networks) guide to top-level design shows the initial steps in the process of deploying CVISN in a state. For purposes of these guides, top-level design encompasses setting the scope of the projec...

Algorithm for cellular reprogramming.

PubMed

Ronquist, Scott; Patterson, Geoff; Muir, Lindsey A; Lindsly, Stephen; Chen, Haiming; Brown, Markus; Wicha, Max S; Bloch, Anthony; Brockett, Roger; Rajapakse, Indika

2017-11-07

The day we understand the time evolution of subcellular events at a level of detail comparable to physical systems governed by Newton's laws of motion seems far away. Even so, quantitative approaches to cellular dynamics add to our understanding of cell biology. With data-guided frameworks we can develop better predictions about, and methods for, control over specific biological processes and system-wide cell behavior. Here we describe an approach for optimizing the use of transcription factors (TFs) in cellular reprogramming, based on a device commonly used in optimal control. We construct an approximate model for the natural evolution of a cell-cycle-synchronized population of human fibroblasts, based on data obtained by sampling the expression of 22,083 genes at several time points during the cell cycle. To arrive at a model of moderate complexity, we cluster gene expression based on division of the genome into topologically associating domains (TADs) and then model the dynamics of TAD expression levels. Based on this dynamical model and additional data, such as known TF binding sites and activity, we develop a methodology for identifying the top TF candidates for a specific cellular reprogramming task. Our data-guided methodology identifies a number of TFs previously validated for reprogramming and/or natural differentiation and predicts some potentially useful combinations of TFs. Our findings highlight the immense potential of dynamical models, mathematics, and data-guided methodologies for improving strategies for control over biological processes. Copyright © 2017 the Author(s). Published by PNAS.

Decreasing Turnaround Time and Increasing Patient Satisfaction in a Safety Net Hospital-Based Pediatrics Clinic Using Lean Six Sigma Methodologies.

PubMed

Jayasinha, Yasangi

2016-01-01

Increasingly, health care quality indicators are focusing on patient-centeredness as an indicator of performance. The National Quality Forum lists assessment of patient experience, often conducted using patient surveys, as a top priority. We developed a patient-reported time stamp data collection tool that was used to collect cycle times in a safety net hospital-based outpatient pediatrics clinic. Data were collected using patient-reported survey to obtain cycle times in Pediatric clinic, as well as qualitative and quantitative patient satisfaction data. Several rapid-cycle improvements were performed using Lean Six Sigma methodologies to reduce cycle time by eliminating waste and revise unnecessary processes to improve operational effectiveness and patient and staff satisfaction. A total of 94 surveys were collected and revealed average cycle time of 113 minutes. Our measured patient satisfaction rating was 87%. Discharge and check-in processes were identified as the least efficient and were targeted for intervention. Following implementation, the overall cycle time was decreased from 113 to 90 minutes. Patient satisfaction ratings increased from 87% to 95%. We demonstrate that using Lean Six Sigma tools can be invaluable to clinical restructuring and redesign and results in measurable, improved outcomes in care delivery.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Polat, B. D.; Eryilmaz, O. L.; Keles, O

Compositionally graded and non-graded composite SiCu thin films were deposited by magnetron sputtering technique on Cu disks for investigation of their potentials in lithium ion battery applications. The compositionally graded thin film electrodes with 30 at.% Cu delivered a 1400 mAh g-1 capacity with 80% Coulombic efficiency in the first cycle and still retained its capacity at around 600 mAh g-1 (with 99.9% Coulombic efficiency) even after 100 cycles. On the other hand, the non-graded thin film electrodes with 30 at.% Cu exhibited 1100 mAh g-1 as the first discharge capacity with 78% Coulombic efficiency but the cycle life ofmore » this film degraded very quickly, delivering only 250 mAh g-1 capacity after 100th cycles. Not only the Cu content but also the graded film thickness were believed to be the main contributors to the much superior performance of the compositionally graded SiCu films. We also believe that the Cu-rich region of the graded film helped reduce internal stress build-up and thus prevented film delamination during cycling. In particular, the decrease of Cu content from interface region to the top of the coating reduced the possibility of stress build-up across the film during cycling, thus leading to a high electrochemical performance.« less

Top-down beta oscillatory signaling conveys behavioral context in early visual cortex.

PubMed

Richter, Craig G; Coppola, Richard; Bressler, Steven L

2018-05-03

Top-down modulation of sensory processing is a critical neural mechanism subserving numerous important cognitive roles, one of which may be to inform lower-order sensory systems of the current 'task at hand' by conveying behavioral context to these systems. Accumulating evidence indicates that top-down cortical influences are carried by directed interareal synchronization of oscillatory neuronal populations, with recent results pointing to beta-frequency oscillations as particularly important for top-down processing. However, it remains to be determined if top-down beta-frequency oscillations indeed convey behavioral context. We measured spectral Granger Causality (sGC) using local field potentials recorded from microelectrodes chronically implanted in visual areas V1/V2, V4, and TEO of two rhesus macaque monkeys, and applied multivariate pattern analysis to the spatial patterns of top-down sGC. We decoded behavioral context by discriminating patterns of top-down (V4/TEO-to-V1/V2) beta-peak sGC for two different task rules governing correct responses to identical visual stimuli. The results indicate that top-down directed influences are carried to visual cortex by beta oscillations, and differentiate task demands even before visual stimulus processing. They suggest that top-down beta-frequency oscillatory processes coordinate processing of sensory information by conveying global knowledge states to early levels of the sensory cortical hierarchy independently of bottom-up stimulus-driven processing.

Positive pacing in elite IRONMAN triathletes.

PubMed

Angehrn, Nicole; Rüst, Christoph A.; Nikolaidis, Pantelis T.; Rosemann, Thomas; Knechtle, Beat

2016-12-31

Pacing is known to influence athletic performance. For the Ironman triathlon program, a positive pacing strategy, i.e., the continuous decrease of speed over time was recommended. By analyzing split times, we assessed the pacing strategies of the top 100 finishers of the cycling part of 13 Ironman races and of the running part of 11 Ironman races taking place in 2014. Furthermore, sex-associated differences in performance and pacing strategies were calculated. We analyzed 7,687 cycling and 11,894 running split times of 1,392 triathletes (1,263 men, 129 women). Changes in speed were assessed using mixed-effects regression analyses. A continuous decrease in speed was observed during cycling in 10/13 races, and during running in 11/11 races. In 6/13 races, women decreased their speed during cycling significantly more than men. The running part showed no significant difference of changes in speed between the sexes. In summary, in the Ironman races evaluated, a positive pacing strategy was adopted in most races. Women were slower than men in 6/13 cycling races, but there was no difference between men and women in the run splits. Women used the same pacing strategy as men.

Granule size control and targeting in pulsed spray fluid bed granulation.

PubMed

Ehlers, Henrik; Liu, Anchang; Räikkönen, Heikki; Hatara, Juha; Antikainen, Osmo; Airaksinen, Sari; Heinämäki, Jyrki; Lou, Honxiang; Yliruusi, Jouko

2009-07-30

The primary aim of the study was to investigate the effects of pulsed liquid feed on granule size. The secondary aim was to increase knowledge of this technique in granule size targeting. Pulsed liquid feed refers to the pump changing between on- and off-positions in sequences, called duty cycles. One duty cycle consists of one on- and off-period. The study was performed with a laboratory-scale top-spray fluid bed granulator with duty cycle length and atomization pressure as studied variables. The liquid feed rate, amount and inlet air temperature were constant. The granules were small, indicating that the powder has only undergone ordered mixing, nucleation and early growth. The effect of atomizing pressure on granule size depends on inlet air relative humidity, with premature binder evaporation as a reason. The duty cycle length was of critical importance to the end product attributes, by defining the extent of intermittent drying and rewetting. By varying only the duty cycle length, it was possible to control granule nucleation and growth, with a wider granule size target range in increased relative humidity. The present study confirms that pulsed liquid feed in fluid bed granulation is a useful tool in end product particle size targeting.

Top-gate organic depletion and inversion transistors with doped channel and injection contact

NASA Astrophysics Data System (ADS)

Liu, Xuhai; Kasemann, Daniel; Leo, Karl

2015-03-01

Organic field-effect transistors constitute a vibrant research field and open application perspectives in flexible electronics. For a commercial breakthrough, however, significant performance improvements are still needed, e.g., stable and high charge carrier mobility and on-off ratio, tunable threshold voltage, as well as integrability criteria such as n- and p-channel operation and top-gate architecture. Here, we show pentacene-based top-gate organic transistors operated in depletion and inversion regimes, realized by doping source and drain contacts as well as a thin layer of the transistor channel. By varying the doping concentration and the thickness of the doped channel, we control the position of the threshold voltage without degrading on-off ratio or mobility. Capacitance-voltage measurements show that an inversion channel can indeed be formed, e.g., an n-doped channel can be inverted to a p-type inversion channel with highly p-doped contacts. The Cytop polymer dielectric minimizes hysteresis, and the transistors can be biased for prolonged cycles without a shift of threshold voltage, indicating excellent operation stability.

49 CFR 214.109 - Scaffolding.

Code of Federal Regulations, 2012 CFR

2012-10-01

... pounds applied within two inches of the top edge, in any outward or downward direction, at any point along the top edge. (3) Top edge height of toprails, or equivalent guardrail system member, shall be 42..., solid panels, and equivalent structural members shall be capable of withstanding, without failure, a...

49 CFR 214.109 - Scaffolding.

Code of Federal Regulations, 2013 CFR

2013-10-01

... pounds applied within two inches of the top edge, in any outward or downward direction, at any point along the top edge. (3) Top edge height of toprails, or equivalent guardrail system member, shall be 42..., solid panels, and equivalent structural members shall be capable of withstanding, without failure, a...

49 CFR 214.109 - Scaffolding.

Code of Federal Regulations, 2014 CFR

2014-10-01

... pounds applied within two inches of the top edge, in any outward or downward direction, at any point along the top edge. (3) Top edge height of toprails, or equivalent guardrail system member, shall be 42..., solid panels, and equivalent structural members shall be capable of withstanding, without failure, a...

49 CFR 214.109 - Scaffolding.

Code of Federal Regulations, 2011 CFR

2011-10-01

... pounds applied within two inches of the top edge, in any outward or downward direction, at any point along the top edge. (3) Top edge height of toprails, or equivalent guardrail system member, shall be 42..., solid panels, and equivalent structural members shall be capable of withstanding, without failure, a...

KENNEDY SPACE CENTER, FLA. - Crawler-transporter (CT) number 2, moves away from the Vehicle Assembly Building with a Mobile Launcher Platform (MLP) on top on a test run to the launch pad. The CT recently underwent modifications to the cab. The CT moves Space Shuttle vehicles, situated on the MLP, between the VAB and launch pad. Moving on four double-tracked crawlers, the CT uses a laser guidance system and a leveling system for the journey that keeps the top of a Space Shuttle vertical within plus- or minus-10 minutes of arc. The system enables the CT-MLP-Shuttle to negotiate the ramp leading to the launch pads and keep the load level. Unloaded, the CT weighs 6 million pounds. Seen on top of the MLP are two tail service masts that support the fluid, gas and electrical requirements of the orbiter’s liquid oxygen and liquid hydrogen aft umbilicals.

NASA Image and Video Library

2003-08-18

KENNEDY SPACE CENTER, FLA. - Crawler-transporter (CT) number 2, moves away from the Vehicle Assembly Building with a Mobile Launcher Platform (MLP) on top on a test run to the launch pad. The CT recently underwent modifications to the cab. The CT moves Space Shuttle vehicles, situated on the MLP, between the VAB and launch pad. Moving on four double-tracked crawlers, the CT uses a laser guidance system and a leveling system for the journey that keeps the top of a Space Shuttle vertical within plus- or minus-10 minutes of arc. The system enables the CT-MLP-Shuttle to negotiate the ramp leading to the launch pads and keep the load level. Unloaded, the CT weighs 6 million pounds. Seen on top of the MLP are two tail service masts that support the fluid, gas and electrical requirements of the orbiter’s liquid oxygen and liquid hydrogen aft umbilicals.

The Dusty Dynamics Within a Regional Mars Dust Storm

NASA Astrophysics Data System (ADS)

Rafkin, Scot C. R.; Pla-Garcia, Jorge; Leung, Cecilia

2017-10-01

There have never been in situ observations at or near the active lifting center of a regional dust storm on Mars. In the absence of in situ data, it is common to employ numerical models to provide guidance on the physical processes and conditions operating in an unobserved location or weather system. Consequently, the Mars Regional Atmospheric Modeling System (MRAMS) is employed to study the structure and dynamics of a simulated large regional storm using a fully interactive dust cycle. The simulations provide the first ever glimpse of the conditions that might occur inside one of these storms.The simulated storm shows extremely complex structure with narrow lifting centers and a variety of deep dust transport circulations. The active lifting centers are broadly into a mesoscale system in much the same way that thunderstorms on Earth can organize into mesoscale convective structures. In many of the active dusty plumes, the mixing ratio of dust peaks near the surface and drops off with height. Once lifted, the largest dust tends to sediment out while the smaller dust continues to be advected upward by the plume. This size-sorting process combined with entrainment of less dusty air tends to drive the mixing ratio profile to a maximum near the surface. In dusty plumes near the surface, the air temperature is as much as 20K colder than nearby areas. This is due to solar absorption higher in the dust column limiting direct heating deeper into the atmosphere. Overall, within the plume, there is an inversion, and although the top of the plume is warmer than below, it is near neutral buoyancy compared to the less dusty air on either side. Apparently, adiabatic cooling nearly offsets the expected positive heating perturbation at the top of the dusty plume. A very strong low level just forms in the vicinity of the storm, accompanied by system-wide negative pressure deficits and circulation patterns strongly suggestive of the wind-enhanced interaction of radiation and dust (WEIRD) feedback mechanism.

The oak woodland bird conservation plan: a strategy for protecting and managing oak woodland habitats and associated birds in California

Treesearch

Steve Zack; Mary K. Chase; Geoffrey R. Geupel

2002-01-01

Over 330 species of birds, mammals, reptiles, and amphibians depend on oak woodlands in California at some stage in their life cycle. California oak woodlands may rank among the top three habitat types in North America for bird richness. Oak woodlands are able to sustain such abundant wildlife primarily because they produce acorns, a high quality and frequently copious...

40 CFR 246.200-5 - Recommended procedures: Methods of separation and collection.

Code of Federal Regulations, 2012 CFR

2012-07-01

... designed to recover high grades of office paper at the source of generation, i.e., the desk, are the... recommended system is the desk-top system because it is designed to maximize recovery of high value material... desk-top system has been designed to minimize these problems. (d) The precise method of separation and...

40 CFR 246.200-5 - Recommended procedures: Methods of separation and collection.

Code of Federal Regulations, 2013 CFR

2013-07-01

... designed to recover high grades of office paper at the source of generation, i.e., the desk, are the... recommended system is the desk-top system because it is designed to maximize recovery of high value material... desk-top system has been designed to minimize these problems. (d) The precise method of separation and...

40 CFR 246.200-5 - Recommended procedures: Methods of separation and collection.

Code of Federal Regulations, 2011 CFR

2011-07-01

... designed to recover high grades of office paper at the source of generation, i.e., the desk, are the... recommended system is the desk-top system because it is designed to maximize recovery of high value material... desk-top system has been designed to minimize these problems. (d) The precise method of separation and...

40 CFR 246.200-5 - Recommended procedures: Methods of separation and collection.

Code of Federal Regulations, 2010 CFR

2010-07-01

... designed to recover high grades of office paper at the source of generation, i.e., the desk, are the... recommended system is the desk-top system because it is designed to maximize recovery of high value material... desk-top system has been designed to minimize these problems. (d) The precise method of separation and...

40 CFR 246.200-5 - Recommended procedures: Methods of separation and collection.

Code of Federal Regulations, 2014 CFR

2014-07-01

... designed to recover high grades of office paper at the source of generation, i.e., the desk, are the... recommended system is the desk-top system because it is designed to maximize recovery of high value material... desk-top system has been designed to minimize these problems. (d) The precise method of separation and...

VoroTop: Voronoi cell topology visualization and analysis toolkit

NASA Astrophysics Data System (ADS)

Lazar, Emanuel A.

2018-01-01

This paper introduces a new open-source software program called VoroTop, which uses Voronoi topology to analyze local structure in atomic systems. Strengths of this approach include its abilities to analyze high-temperature systems and to characterize complex structure such as grain boundaries. This approach enables the automated analysis of systems and mechanisms previously not possible.

APS TBC performance on directionally-solidified superalloy substrates with HVOF NiCoCrAlYHfSi bond coatings

DOE PAGES

Lance, Michael J.; Unocic, Kinga A.; Haynes, James A.; ...

2015-09-04

Directionally-solidified (DS) superalloy components with advanced thermal barrier coatings (TBC) to lower the metal operating temperature have the potential to replace more expensive single crystal superalloys for large land-based turbines. In order to assess relative TBC performance, furnace cyclic testing was used with superalloys 1483, X4 and Hf-rich DS 247 substrates and high velocity oxygen fuel (HVOF)-NiCoCrAlYHfSi bond coatings at 1100 °C with 1-h cycles in air with 10% H 2O. With these coating and test conditions, there was no statistically-significant effect of substrate alloy on the average lifetime of the air plasma sprayed (APS) yttria-stabilized zirconia (YSZ) top coatingsmore » on small coupons. Using photo-stimulated luminescence piezospectroscopy maps at regular cycling intervals, the residual compressive stress in the α-Al 2O 3 scale underneath the YSZ top coating and on a bare bond coating was similar for all three substrates and delaminations occurred at roughly the same rate and frequency. As a result, x-ray fluorescence (XRF) measurements collected from the bare bond coating surface revealed higher Ti interdiffusion occurring with the 1483 substrate, which contained the highest Ti content.« less

Combinatorial modification of human histone H4 quantitated by two-dimensional liquid chromatography coupled with top down mass spectrometry.

PubMed

Pesavento, James J; Bullock, Courtney R; LeDuc, Richard D; Mizzen, Craig A; Kelleher, Neil L

2008-05-30

Quantitative proteomics has focused heavily on correlating protein abundances, ratios, and dynamics by developing methods that are protein expression-centric (e.g. isotope coded affinity tag, isobaric tag for relative and absolute quantification, etc.). These methods effectively detect changes in protein abundance but fail to provide a comprehensive perspective of the diversity of proteins such as histones, which are regulated by post-translational modifications. Here, we report the characterization of modified forms of HeLa cell histone H4 with a dynamic range >10(4) using a strictly Top Down mass spectrometric approach coupled with two dimensions of liquid chromatography. This enhanced dynamic range enabled the precise characterization and quantitation of 42 forms uniquely modified by combinations of methylation and acetylation, including those with trimethylated Lys-20, monomethylated Arg-3, and the novel dimethylated Arg-3 (each <1% of all H4 forms). Quantitative analyses revealed distinct trends in acetylation site occupancy depending on Lys-20 methylation state. Because both modifications are dynamically regulated through the cell cycle, we simultaneously investigated acetylation and methylation kinetics through three cell cycle phases and used these data to statistically assess the robustness of our quantitative analysis. This work represents the most comprehensive analysis of histone H4 forms present in human cells reported to date.

Flexible, transparent and high-power triboelectric generator with asymmetric graphene/ITO electrodes.

PubMed

Song, Xinbo; Chen, Yuanfu; Li, Pingjian; Liu, Jingbo; Qi, Fei; Zheng, Binjie; Zhou, Jinhao; Hao, Xin; Zhang, Wanli

2016-07-29

The reported flexible and transparent triboelectric generator (FTTG) can only output ultralow power density (∼2 μW cm(-2)), which has seriously hindered its further development and application. The low power density of FTTG is mainly limited by the transparent material and the electrode structure. Herein, for the first time, a FTTG with a superior power density of 60.7 μW cm(-2) has been fabricated by designing asymmetric electrodes where graphene and indium tin oxide (ITO) act as top and bottom electrodes respectively. Moreover, the performance of FTTG with graphene/ITO (G/I) asymmetric electrodes (GI-FTTG) almost remains unchanged even after 700 cycles, indicating excellent mechanical stability. The excellent performance of GI-FTTG can be attributed to the suitable materials and unique asymmetric electrode structure: the extraordinary flexibility of the graphene top electrode ensures the GI-FTTG excellent mechanical robustness and stability even after longer cycles, and the bottom electrode with very low sheet resistance guarantees lower internal resistance and higher production rate of induction charges to obtain higher output power density. It shows that light-emitting diodes (LED) can be easily powered by GI-FTTG, which demonstrates that the GI-FTTG is very promising for harvesting electrical energy from human activities by using flexible and transparent devices.

Tune variations in the Large Hadron Collider

NASA Astrophysics Data System (ADS)

Aquilina, N.; Giovannozzi, M.; Lamont, M.; Sammut, N.; Steinhagen, R.; Todesco, E.; Wenninger, J.

2015-04-01

The horizontal and vertical betatron tunes of the Large Hadron Collider (LHC) mainly depend on the strength of the quadrupole magnets, but are also affected by the quadrupole component in the main dipoles. In case of systematic misalignments, the sextupole component from the main dipoles and sextupole corrector magnets also affect the tunes due to the feed down effect. During the first years of operation of the LHC, the tunes have been routinely measured and corrected through either a feedback or a feed forward system. In this paper, the evolution of the tunes during injection, ramp and flat top are reconstructed from the beam measurements and the settings of the tune feedback loop and of the feed forward corrections. This gives the obtained precision of the magnetic model of the machine with respect to quadrupole and sextupole components. Measurements at the injection plateau show an unexpected large decay whose origin is not understood. This data is discussed together with the time constants and the dependence on previous cycles. We present results of dedicated experiments that show that this effect does not originate from the decay of the main dipole component. During the ramp, the tunes drift by about 0.022. It is shown that this is related to the precision of tracking the quadrupole field in the machine and this effect is reduced to about 0.01 tune units during flat top.

Effects of nitrogen and biochar amendment on soil methane concentration profiles and diffusion in a rice-wheat annual rotation system

NASA Astrophysics Data System (ADS)

Xu, Xin; Wu, Zhen; Dong, Yubing; Zhou, Ziqiang; Xiong, Zhengqin

2016-12-01

The CH4 emissions from soil were influenced by the changeable CH4 concentrations and diffusions in soil profiles, but that have been subjected to nitrogen (N) and biochar amendment over seasonal and annual time frames. Accordingly, a two-year field experiment was conducted in southeastern China to determine the amendment effects on CH4 concentrations and diffusive effluxes as measured by a multilevel sampling probe in paddy soil during two cycles of rice-wheat rotations. The results showed that the top 7-cm soil layers were the primary CH4 production sites during the rice-growing seasons. This layer acted as the source of CH4 generation and diffusion, and the deeper soil layers and the wheat season soil acted as the sink. N fertilization significantly increased the CH4 concentration and diffusive effluxes in the top 7-cm layers during the 2013 and 2014 rice seasons. Following biochar amendment, the soil CH4 concentrations significantly decreased during the rice season in 2014, relative to the single N treatment. Moreover, 40 t ha-1 biochar significantly decreased the diffusive effluxes during the rice seasons in both years. Therefore, our results showed that biochar amendment is a good strategy for reducing the soil profile CH4 concentrations and diffusive effluxes induced by N in paddy fields.

Illumination design for semiconductor backlight inspection and application extensions

NASA Astrophysics Data System (ADS)

Zhou, Wei; Rutherford, Todd; Hart, Darcy

2013-09-01

High speed strobe based illumination scheme is one of the most critical factors for high throughput semiconductor defect inspection applications. HB LEDs are always the first and best options for such applications due to numerous unique advantages such as excellent spatial and temporal stability, fast responding time, large and linear intensity dynamic range and no heat issue for the extremely low duty cycle applications. For some applications where a large area is required to be illuminated simultaneously, it remains a great challenge to efficiently package a large amount of HB-LEDs in a highly confined 3D space, to generate a seamless illuminated area with high luminance efficiency and spatial uniformity. A novel 3D structured collimation lens is presented in this paper. The non-circular edge shape reduces the intensity drop at the channel boundaries, while the secondary curvatures on the top of the collimator lens efficiently guides the light into desired angular space. The number of the edges and the radius of the top surface curvature are control parameters for the system level performance and the manufacture cost trade-off. The proposed 3D structured LED collimation lens also maintains the benefits of traditional LED collimation lens such as coupling efficiency and mold manufacture capability. The applications can be extended into other non-illumination area like parallelism measurement and solar panel concentrator etc.

Effects of nitrogen and biochar amendment on soil methane concentration profiles and diffusion in a rice-wheat annual rotation system.

PubMed

Xu, Xin; Wu, Zhen; Dong, Yubing; Zhou, Ziqiang; Xiong, Zhengqin

2016-12-08

The CH 4 emissions from soil were influenced by the changeable CH 4 concentrations and diffusions in soil profiles, but that have been subjected to nitrogen (N) and biochar amendment over seasonal and annual time frames. Accordingly, a two-year field experiment was conducted in southeastern China to determine the amendment effects on CH 4 concentrations and diffusive effluxes as measured by a multilevel sampling probe in paddy soil during two cycles of rice-wheat rotations. The results showed that the top 7-cm soil layers were the primary CH 4 production sites during the rice-growing seasons. This layer acted as the source of CH 4 generation and diffusion, and the deeper soil layers and the wheat season soil acted as the sink. N fertilization significantly increased the CH 4 concentration and diffusive effluxes in the top 7-cm layers during the 2013 and 2014 rice seasons. Following biochar amendment, the soil CH 4 concentrations significantly decreased during the rice season in 2014, relative to the single N treatment. Moreover, 40 t ha -1 biochar significantly decreased the diffusive effluxes during the rice seasons in both years. Therefore, our results showed that biochar amendment is a good strategy for reducing the soil profile CH 4 concentrations and diffusive effluxes induced by N in paddy fields.

Enhanced oil recovery system

DOEpatents

Goldsberry, Fred L.

1989-01-01

All energy resources available from a geopressured geothermal reservoir are used for the production of pipeline quality gas using a high pressure separator/heat exchanger and a membrane separator, and recovering waste gas from both the membrane separator and a low pressure separator in tandem with the high pressure separator for use in enhanced oil recovery, or in powering a gas engine and turbine set. Liquid hydrocarbons are skimmed off the top of geothermal brine in the low pressure separator. High pressure brine from the geothermal well is used to drive a turbine/generator set before recovering waste gas in the first separator. Another turbine/generator set is provided in a supercritical binary power plant that uses propane as a working fluid in a closed cycle, and uses exhaust heat from the combustion engine and geothermal energy of the brine in the separator/heat exchanger to heat the propane.

Synergetic use of Aerosol Robotic Network (AERONET) and Moderate Image Spectrometer (MODIS)

NASA Technical Reports Server (NTRS)

Kaufman, Y.

2004-01-01

I shall describe several distinct modes in which AERONET data are used in conjunction with MODIS data to evaluate the global aerosol system and its impact on climate. These includes: 1) Evaluation of the aerosol diurnal cycle not available from MODIS, and the relationship between the aerosol properties derived from MODIS and the daily average of these properties; 2) Climatology of the aerosol size distribution and single scattering albedo. The climatology is used to formulate the assumptions used in the MODIS look up tables used in the inversion of MODIS data; 3) Measurement of the aerosol effect on irradiation of the surface, this is used in conjunction with the MODIS evaluation of the aerosol effect at the TOA; and 4) Assessment of the aerosol baseline on top off which the satellite data are used to find the amount of dust or anthropogenic aerosol.

Extraction and Analysis of Display Data

NASA Technical Reports Server (NTRS)

Land, Chris; Moye, Kathryn

2008-01-01

The Display Audit Suite is an integrated package of software tools that partly automates the detection of Portable Computer System (PCS) Display errors. [PCS is a lap top computer used onboard the International Space Station (ISS).] The need for automation stems from the large quantity of PCS displays (6,000+, with 1,000,000+ lines of command and telemetry data). The Display Audit Suite includes data-extraction tools, automatic error detection tools, and database tools for generating analysis spread sheets. These spread sheets allow engineers to more easily identify many different kinds of possible errors. The Suite supports over 40 independent analyses, 16 NASA Tech Briefs, November 2008 and complements formal testing by being comprehensive (all displays can be checked) and by revealing errors that are difficult to detect via test. In addition, the Suite can be run early in the development cycle to find and correct errors in advance of testing.

Scenic Byways, Transportation & Public Facilities, State of Alaska

Science.gov Websites

Sterling Highway: north segment Sterling Highway: south segment Taylor & Top of the World Highways Highway Taylor Highway & Top of the World Highway Alaska Railroad Prince of Wales Island Road System Highway - northern segment Taylor & Top of the World Highways Alaska Railroad Alaska Railroad Parks

Diagnostic Systems Plan for the Advanced Light Source Top-OffUpgrade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barry, Walter; Chin, Mike; Robin, David

2005-05-10

The Advanced Light Source (ALS) will soon be upgraded to enable top-off operations [1], in which electrons are quasi-continuously injected to produce constant stored beam current. The upgrade is structured in two phases. First, we will upgrade our injector from 1.5 GeV to 1.9 GeV to allow full energy injection and will start top-off operations. In the second phase, we will upgrade the Booster Ring (BR) with a bunch cleaning system to allow high bunch purity top-off injection. A diagnostics upgrade will be crucial for success in both phases of the top-off project, and our plan for it is describedmore » in this paper. New booster ring diagnostics will include updated beam position monitor (BPM) electronics, a tune monitoring system, and a new scraper. Two new synchrotron light monitors and a beam stop will be added to the booster-to-storage ring transfer line (BTS), and all the existing beam current monitors along the accelerator chain will be integrated into a single injection efficiency monitoring application. A dedicated bunch purity monitor will be installed in the storage ring (SR). Together, these diagnostic upgrades will enable smooth commissioning of the full energy injector and a quick transition to high quality top-off operation at the ALS.« less

Rectification of the Diurnal Cycle and the Impact of Islands on the Tropical Climate

NASA Astrophysics Data System (ADS)

Cronin, T. W.; Emanuel, K.

2012-12-01

Tropical islands are observed to be rainier than nearby ocean areas, and rainfall over the islands of the Maritime Continent plays an important role in the atmospheric general circulation. Convective heating over tropical islands is also strongly modulated by the diurnal cycle of solar insolation and surface enthalpy fluxes, and convective parameterizations in general circulation models are known to reproduce the phase and amplitude of the observed diurnal cycle of convection rather poorly. Connecting these ideas suggests that poor representation of the diurnal cycle of convection and precipitation over tropical islands in climate models may be a significant source of model biases. Here, we explore how a highly idealized island, which differs only in heat capacity from the surrounding ocean, could rectify the diurnal cycle and impact the tropical climate, especially the spatial distribution of rainfall. We perform simulations of radiative-convective equilibrium with the System for Atmospheric Modeling cloud-system-resolving model, with interactive surface temperature and a varied surface heat capacity. For the case of relatively small-scale simulations, where a shallow (~5 cm) slab-ocean "swamp island" surface is embedded in a deeper (~1 m) slab-ocean domain, the precipitation rate over the island is more than double the domain average value, with island rainfall occurring primarily in a strong regular convective event each afternoon. In addition to this island precipitation enhancement, the upper troposphere also warms with the inclusion of a low- heat capacity island. We discuss two radiative mechanisms that contribute to both island precipitation enhancement and free tropospheric warming, by producing a top-of-atmosphere radiative surplus over the island. The first radiative mechanism is a clear-sky effect, related to nonlinearities in the surface energy budget, and differences in how surface energy balance is achieved over surfaces of different heat capacities. The second radiative mechanism is a cloudy-sky effect, related to the timing of clouds with respect to solar forcing, as well as to the mean cloud fraction and height. We also discuss an advective mechanism for island precipitation enhancement, related to both the moist static energy convergence by the diurnally-reversing land/sea breeze, and the enhanced variability of moist static energy in the island subcloud layer. Preliminary results from larger-domain equatorial beta-channel simulations are also discussed, with potentially greater applicability to the impacts of islands on the large-scale tropical circulation.

Top-down Proteomics in Health and Disease: Challenges and Opportunities

PubMed Central

Gregorich, Zachery R.; Ge, Ying

2014-01-01

Proteomics is essential for deciphering how molecules interact as a system and for understanding the functions of cellular systems in human disease; however, the unique characteristics of the human proteome, which include a high dynamic range of protein expression and extreme complexity due to a plethora of post-translational modifications (PTMs) and sequence variations, make such analyses challenging. An emerging “top-down” mass spectrometry (MS)-based proteomics approach, which provides a “bird’s eye” view of all proteoforms, has unique advantages for the assessment of PTMs and sequence variations. Recently, a number of studies have showcased the potential of top-down proteomics for unraveling of disease mechanisms and discovery of new biomarkers. Nevertheless, the top-down approach still faces significant challenges in terms of protein solubility, separation, and the detection of large intact proteins, as well as the under-developed data analysis tools. Consequently, new technological developments are urgently needed to advance the field of top-down proteomics. Herein, we intend to provide an overview of the recent applications of top-down proteomics in biomedical research. Moreover, we will outline the challenges and opportunities facing top-down proteomics strategies aimed at understanding and diagnosing human diseases. PMID:24723472

TOP500 Sublist for November 2001

DOE Office of Scientific and Technical Information (OSTI.GOV)

Strohmaier, Erich; Meuer, Hans W.; Dongarra, Jack J.

2001-11-09

18th Edition of TOP500 List of World's Fastest Supercomputers Released MANNHEIM, GERMANY; KNOXVILLE, TENN.; BERKELEY, CALIF. In what has become a much-anticipated event in the world of high-performance computing, the 18th edition of the TOP500 list of the world's fastest supercomputers was released today (November 9, 2001). The latest edition of the twice-yearly ranking finds IBM as the leader in the field, with 32 percent in terms of installed systems and 37 percent in terms of total performance of all the installed systems. In a surprise move Hewlett-Packard captured the second place with 30 percent of the systems. Most ofmore » these systems are smaller in size and as a consequence HP's share of installed performance is smaller with 15 percent. This is still enough for second place in this category. SGI, Cray and Sun follow in the number of TOP500 systems with 41 (8 percent), 39 (8 percent), and 31 (6 percent) respectively. In the category of installed performance Cray Inc. keeps the third position with 11 percent ahead of SGI (8 percent) and Compaq (8 percent).« less

In situ analysis of capacity fade in thin-film anodes for high performance Li-ion all-solid-state batteries

NASA Astrophysics Data System (ADS)

Leite, Marina S.; Gong, Chen; Ruzmetov, Dmitry; Talin, A. Alec

There is still a pressing need to understand how the solid-interfaces in Li-ion all-solid-batteries form, including their chemical composition and electrical characteristics. In order to resolve the origin of the degradation mechanism in Al anodes, we combine in situ scanning electron microscopy in ultra-high vacuum with electrochemical cycling, in addition to ex situ characterization of the morphological, chemical, and electrical changes of the Al anodes upon lithiation. An AlLi alloy capped by a stable Al-Li-O is formed on the top surface of the anode, trapping Li, which results in the capacity fade, from 48.0 to 41.5 μ.Ah/cm2 in two cycles. The addition of a Cu capping layer is insufficient to prevent the device degradation because of the fast Li diffusion within Al. Yet, Si present extremely stable cycling: >92% of capacity retention after 100 cycles, with average Coulombic efficiency of 98%. Our in situ measurements represent a new platform for probing the real-time degradation of electrodes in all-solid-state batteries for energy storage devices.

Comparison of pharmacological activity of macitentan and bosentan in preclinical models of systemic and pulmonary hypertension.

PubMed

Iglarz, Marc; Bossu, Alexandre; Wanner, Daniel; Bortolamiol, Céline; Rey, Markus; Hess, Patrick; Clozel, Martine

2014-11-24

The endothelin (ET) system is a tissular system, as the production of ET isoforms is mostly autocrine or paracrine. Macitentan is a novel dual ETA/ETB receptor antagonist with enhanced tissue distribution and sustained receptor binding properties designed to achieve a more efficacious ET receptor blockade. To determine if these features translate into improved efficacy in vivo, a study was designed in which rats with either systemic or pulmonary hypertension and equipped with telemetry were given macitentan on top of maximally effective doses of another dual ETA/ETB receptor antagonist, bosentan, which does not display sustained receptor occupancy and shows less tissue distribution. After establishing dose-response curves of both compounds in conscious, hypertensive Dahl salt-sensitive and pulmonary hypertensive bleomycin-treated rats, macitentan was administered on top of the maximal effective dose of bosentan. In hypertensive rats, macitentan 30 mg/kg further decreased mean arterial blood pressure (MAP) by 19 mm Hg when given on top of bosentan 100 mg/kg (n=9, p<0.01 vs. vehicle). Conversely, bosentan given on top of macitentan failed to induce an additional MAP decrease. In pulmonary hypertensive rats, macitentan 30 mg/kg further decreased mean pulmonary artery pressure (MPAP) by 4 mm Hg on top of bosentan (n=8, p<0.01 vs. vehicle), whereas a maximal effective dose of bosentan given on top of macitentan did not cause any additional MPAP decrease. The add-on effect of macitentan on top of bosentan in two pathological models confirms that this novel compound can achieve a superior blockade of ET receptors and provides evidence for greater maximal efficacy. Copyright © 2014. Published by Elsevier Inc.

ACS from development to operations

NASA Astrophysics Data System (ADS)

Caproni, Alessandro; Colomer, Pau; Jeram, Bogdan; Sommer, Heiko; Chiozzi, Gianluca; Mañas, Miguel M.

2016-08-01

The ALMA Common Software (ACS), provides the infrastructure of the distributed software system of ALMA and other projects. ACS, built on top of CORBA and Data Distribution Service (DDS) middleware, is based on a Component- Container paradigm and hides the complexity of the middleware allowing the developer to focus on domain specific issues. The transition of the ALMA observatory from construction to operations brings with it that ACS effort focuses primarily on scalability, stability and robustness rather than on new features. The transition came together with a shorter release cycle and a more extensive testing. For scalability, the most problematic area has been the CORBA notification service, used to implement the publisher subscriber pattern because of the asynchronous nature of the paradigm: a lot of effort has been spent to improve its stability and recovery from run time errors. The original bulk data mechanism, implemented using the CORBA Audio/Video Streaming Service, showed its limitations and has been replaced with a more performant and scalable DDS implementation. Operational needs showed soon the difference between releases cycles for Online software (i.e. used during observations) and Offline software, which requires much more frequent releases. This paper attempts to describe the impact the transition from construction to operations had on ACS, the solution adopted so far and a look into future evolution.

Use of Atmospheric Budget to Reduce Uncertainty in Estimated Water Availability over South Asia from Different Reanalyses

NASA Astrophysics Data System (ADS)

Sebastian, Dawn Emil; Pathak, Amey; Ghosh, Subimal

2016-07-01

Disagreements across different reanalyses over South Asia result into uncertainty in assessment of water availability, which is computed as the difference between Precipitation and Evapotranspiration (P-E). Here, we compute P-E directly from atmospheric budget with divergence of moisture flux for different reanalyses and find improved correlation with observed values of P-E, acquired from station and satellite data. We also find reduced closure terms for water cycle computed with atmospheric budget, analysed over South Asian landmass, when compared to that obtained with individual values of P and E. The P-E value derived with atmospheric budget is more consistent with energy budget, when we use top-of-atmosphere radiation for the same. For analysing water cycle, we use runoff from Global Land Data Assimilation System, and water storage from Gravity Recovery and Climate Experiment. We find improvements in agreements across different reanalyses, in terms of inter-annual cross correlation when atmospheric budget is used to estimate P-E and hence, emphasize to use the same for estimations of water availability in South Asia to reduce uncertainty. Our results on water availability with reduced uncertainty over highly populated monsoon driven South Asia will be useful for water management and agricultural decision making.

Use of Atmospheric Budget to Reduce Uncertainty in Estimated Water Availability over South Asia from Different Reanalyses.

PubMed

Sebastian, Dawn Emil; Pathak, Amey; Ghosh, Subimal

2016-07-08

Disagreements across different reanalyses over South Asia result into uncertainty in assessment of water availability, which is computed as the difference between Precipitation and Evapotranspiration (P-E). Here, we compute P-E directly from atmospheric budget with divergence of moisture flux for different reanalyses and find improved correlation with observed values of P-E, acquired from station and satellite data. We also find reduced closure terms for water cycle computed with atmospheric budget, analysed over South Asian landmass, when compared to that obtained with individual values of P and E. The P-E value derived with atmospheric budget is more consistent with energy budget, when we use top-of-atmosphere radiation for the same. For analysing water cycle, we use runoff from Global Land Data Assimilation System, and water storage from Gravity Recovery and Climate Experiment. We find improvements in agreements across different reanalyses, in terms of inter-annual cross correlation when atmospheric budget is used to estimate P-E and hence, emphasize to use the same for estimations of water availability in South Asia to reduce uncertainty. Our results on water availability with reduced uncertainty over highly populated monsoon driven South Asia will be useful for water management and agricultural decision making.

Use of Atmospheric Budget to Reduce Uncertainty in Estimated Water Availability over South Asia from Different Reanalyses

PubMed Central

Sebastian, Dawn Emil; Pathak, Amey; Ghosh, Subimal

2016-01-01

Disagreements across different reanalyses over South Asia result into uncertainty in assessment of water availability, which is computed as the difference between Precipitation and Evapotranspiration (P–E). Here, we compute P–E directly from atmospheric budget with divergence of moisture flux for different reanalyses and find improved correlation with observed values of P–E, acquired from station and satellite data. We also find reduced closure terms for water cycle computed with atmospheric budget, analysed over South Asian landmass, when compared to that obtained with individual values of P and E. The P–E value derived with atmospheric budget is more consistent with energy budget, when we use top-of-atmosphere radiation for the same. For analysing water cycle, we use runoff from Global Land Data Assimilation System, and water storage from Gravity Recovery and Climate Experiment. We find improvements in agreements across different reanalyses, in terms of inter-annual cross correlation when atmospheric budget is used to estimate P–E and hence, emphasize to use the same for estimations of water availability in South Asia to reduce uncertainty. Our results on water availability with reduced uncertainty over highly populated monsoon driven South Asia will be useful for water management and agricultural decision making. PMID:27388837

Pressurized Pepsin Digestion in Proteomics: An Automatable Alternative to Trypsin for Integrated Top-down Bottom-up Proteomics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lopez-Ferrer, Daniel; Petritis, Konstantinos; Robinson, Errol W.

2011-02-01

Integrated top-down bottom-up proteomics combined with online digestion has great potential to improve the characterization of protein isoforms in biological systems and is amendable to highthroughput proteomics experiments. Bottom-up proteomics ultimately provides the peptide sequences derived from the tandem MS analyses of peptides after the proteome has been digested. Top-down proteomics conversely entails the MS analyses of intact proteins for more effective characterization of genetic variations and/or post-translational modifications (PTMs). Herein, we describe recent efforts towards efficient integration of bottom-up and top-down LCMS based proteomic strategies. Since most proteomic platforms (i.e. LC systems) operate in acidic environments, we exploited themore » compatibility of the pepsin (i.e. the enzyme’s natural acidic activity) for the integration of bottom-up and top-down proteomics. Pressure enhanced pepsin digestions were successfully performed and characterized with several standard proteins in either an offline mode using a Barocycler or an online mode using a modified high pressure LC system referred to as a fast online digestion system (FOLDS). FOLDS was tested using pepsin and a whole microbial proteome, and the results compared against traditional trypsin digestions on the same platform. Additionally, FOLDS was integrated with a RePlay configuration to demonstrate an ultra-rapid integrated bottom-up top-down proteomic strategy employing a standard mixture of proteins and a monkey pox virus proteome.« less

The effects of urbanization on trophic interactions in a desert landscape

USDA-ARS?s Scientific Manuscript database

Background/Question/Methods: Trophic systems can be affected through top-down (predators) and bottom-up (resources) impacts. Human activity can alter trophic systems by causing predators to avoid areas (top-down) or by providing increased resources through irrigation and decorative plants that attra...

Regional, Intraseasonal, and Diurnal Variability of Convection associated with the Boreal Summer Intraseasonal Oscillation over and around the South China Sea

NASA Astrophysics Data System (ADS)

Xu, W.; Rutledge, S. A.

2017-12-01

Weather forecasting and climate models have difficulty in simulating the BSISO due to incomplete understanding of the underlying multiscale physical processes, which also motivates the PISTON field campaign to be held in the SCS in 2018. In preparation for PISTON, this study investigates the regional, intraseasonal, and diurnal variability of BSISO-associated convection over the SCS and surrounding landmasses using long-term satellite data. The SCS is characterized by suppressed precipitation and weak southerlies during inactive BSISO phases (BSISO-1 index, phases 1-3), while a substantial northwest-southeast oriented rainband and strong low-level westerlies dominate active BSISO phases (phases 5-7). In general, convective intensity (e.g., radar echo-top height) and lightning activity are in phase with rainfall over the SCS. However, convective intensity and lightning are out of phase with rainfall over landmasses along the BSISO rainband (e.g., Indochina and Philippines). During active BSISO phases, convective systems over both land and ocean are characterized by larger size, colder cloud tops (IR), and greater fraction of stratiform precipitation. Convection over the SCS during active BSISO phases has taller precipitation echoes (20-dBZ echo top heights), higher lightning density, stronger microwave ice scattering signatures, and more robust mixed-phase microphysics (larger 30/40 dBZ echo volume above the freezing level). These same parameters maximize over land masses of Indochina and the Philippines during BSISO inactive periods. Statistics of environmental conditions suggest that the peak convection over land is due to stronger surface heating (thus higher CAPE) during inactive phases, whereas larger sea surface heat fluxes (leading to higher CAPE) during active phases enhances convective intensity over the SCS. On the other hand, mesoscale organization, convective intensity, and microphysical properties of precipitation systems to the south and north of the BSISO key rainband region have only negligible intraseasonal variability. Land convection shows a strong diurnal cycle (maximizing at afternoon and early evening) across all BSISO phases, while offshore convection peaks at midnight and early morning times during inactive BSISO phases.

TU-H-CAMPUS-IeP2-03: Development of 3D Printed Coronary Phantoms for In-Vitro CT-FFR Validation Using Data from 320- Detector Row Coronary CT Angiography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ionita, C; Rudin, S; Bednarek, D

Purpose: To validate Computed Tomography Fractional Flow Reserve (CT-FFR) measurements with accurate 3D printed coronary phantoms. Methods: DICOM data from four phases in two patients imaged with a standard 320 × 0.5mm coronary CT acquisition (70–80% cardiac cycle) underwent semi-automated segmentation using a research workstation. Both patients had a >50% stenosis from the clinical image interpretation. Each volume was saved as a Stereo Lithographic (STL) file with 250 micron resolution. The 3D geometries were qualitatively assessed; the best of the four phases was 3D printed using a Stratasys Eden260V printer in Tango+, a rubber-like material that roughly emulates mechanical propertiesmore » of human vasculature. We connected the model to a programmable pump and measured the pressure drop using pressure sensors embedded proximal and distal to the arterial stenosis. Next, the STL files used for the 3D printed models were uploaded in the ANSYS meshing tool (ICEM CFD 16.1). A standard meshing process was applied and the meshed geometry was directly imported in the ANSYS Fluent for Computational Flow Dynamics simulations. The CFD simulations were used to calculate the CT-FFR and compared to the bench top FFR measured in the 3D printed phantoms. Results: FFR-CT measurements and phantoms were completed in within an hour after the segmentation. Patient 1 had a 60% stenosis that resulted in a CT-FFR of 0.68. The second case had a 50% stenosis and a CT-FFR of 0.75. The average bench top FFR measurements were 0.72 and 0.80, respectively. Conclusion: This pilot investigation demonstrated the use of a bench-top coronary model for CT-FFR validation. The measurements and the CFD simulations agreed within 6%. Project supported by Support: Toshiba America Medical Systems Corp.and NIH grant R01-EB002873. Project supported by Toshiba America Medical Systems Corp.and partial support from NIH grant R01-EB002873.« less

Stable wafer-carrier system

DOEpatents

Rozenzon, Yan; Trujillo, Robert T; Beese, Steven C

2013-10-22

One embodiment of the present invention provides a wafer-carrier system used in a deposition chamber for carrying wafers. The wafer-carrier system includes a base susceptor and a top susceptor nested inside the base susceptor with its wafer-mounting side facing the base susceptor's wafer-mounting side, thereby forming a substantially enclosed narrow channel. The base susceptor provides an upward support to the top susceptor.

75 FR 33666 - Parts and Accessories Necessary for Safe Operation; Applications for an Exemption From Con-Way...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-14

...), and Iteris, Inc. (Iteris) regarding the placement of lane departure warning system sensors at the top... mounting of the lane departure warning system sensors near the top of the windshield, and within the swept... departure warning system would be used to alert a driver when he or she unintentionally drifts out of their...

Investigation of early timber–concrete composite bridges in the United States

Treesearch

James P. Wacker; Alfredo Dias; Travis K. Hosteng

2017-01-01

The use of timber–concrete composite (TCC) bridges in the United States dates back to circa 1925. Two different TCC systems were constructed during this early period. The first system included a longitudinal nail-laminated deck composite with a concrete deck top layer. The second system included sawn timber stringers supporting a concrete deck top layer. Records...

A Numerical Investigation of the Startup Transient in a Wave Rotor

NASA Technical Reports Server (NTRS)

Paxson, Daniel E.

1996-01-01

The startup process is investigated for a hypothetical four-port wave rotor, envisioned as a topping cycle for a small gas turbine engine. The investigation is conducted numerically using a multi-passage, one-dimensional CFD-based wave rotor simulation in combination with lumped volume models for the combustor, exhaust valve plenum, and rotor center cavity components. The simulation is described and several startup transients are presented which illustrate potential difficulties for the specific cycle design investigated. In particular it is observed that, prior to combustor light-off, or just after, the flow through the combustor loop is reversed from the design direction. The phenomenon is demonstrated and several possible modifications techniques are discussed which avoid or overcome the problem.

Gravity wave initiated convection

NASA Astrophysics Data System (ADS)

Hung, R. J.

1990-09-01

The vertical velocity of convection initiated by gravity waves was investigated. In one particular case, the convective motion-initiated and supported by the gravity wave-induced activity (excluding contributions made by other mechanisms) reached its maximum value about one hour before the production of the funnel clouds. In another case, both rawinsonde and geosynchronous satellite imagery were used to study the life cycles of severe convective storms. Cloud modelling with input sounding data and rapid-scan imagery from GOES were used to investigate storm cloud formation, development and dissipation in terms of growth and collapse of cloud tops, as well as, the life cycles of the penetration of overshooting turrets above the tropopause. The results based on these two approaches are presented and discussed.

Elite triathletes in 'Ironman Hawaii' get older but faster.

PubMed

Gallmann, Dalia; Knechtle, Beat; Rüst, Christoph Alexander; Rosemann, Thomas; Lepers, Romuald

2014-02-01

The age of peak performance has been well investigated for elite athletes in endurance events such as marathon running, but not for ultra-endurance (>6 h) events such as an Ironman triathlon covering 3.8 km swimming, 180 km cycling and 42 km running. The aim of this study was to analyze the changes in the age and performances of the annual top ten women and men at the Ironman World Championship the 'Ironman Hawaii' from 1983 to 2012. Age and performances of the annual top ten women and men in overall race time and in each split discipline were analyzed. The age of the annual top ten finishers increased over time from 26 ± 5 to 35 ± 5 years (r (2) = 0.35, P < 0.01) for women and from 27 ± 2 to 34 ± 3 years (r (2) = 0.28, P < 0.01) for men. Overall race time of the annual top ten finishers decreased across years from 671 ± 16 to 566 ± 8 min (r (2) = 0.44, P < 0.01) for women and from 583 ± 24 to 509 ± 6 min (r (2) = 0.41, P < 0.01) for men. To conclude, the age of annual top ten female and male triathletes in the 'Ironman Hawaii' increased over the last three decades while their performances improved. These findings suggest that the maturity of elite long-distance triathletes has changed during this period and raises the question of the upper limits of the age of peak performance in elite ultra-endurance performance.

Human Planetary Landing System (HPLS) Capability Roadmap NRC Progress Review

NASA Technical Reports Server (NTRS)

Manning, Rob; Schmitt, Harrison H.; Graves, Claude

2005-01-01

Capability Roadmap Team. Capability Description, Scope and Capability Breakdown Structure. Benefits of the HPLS. Roadmap Process and Approach. Current State-of-the-Art, Assumptions and Key Requirements. Top Level HPLS Roadmap. Capability Presentations by Leads. Mission Drivers Requirements. "AEDL" System Engineering. Communication & Navigation Systems. Hypersonic Systems. Super to Subsonic Decelerator Systems. Terminal Descent and Landing Systems. A Priori In-Situ Mars Observations. AEDL Analysis, Test and Validation Infrastructure. Capability Technical Challenges. Capability Connection Points to other Roadmaps/Crosswalks. Summary of Top Level Capability. Forward Work.

Multiscale design and life-cycle based sustainability assessment of polymer nanocomposite coatings

NASA Astrophysics Data System (ADS)

Uttarwar, Rohan G.

In recent years, nanocoatings with exceptionally improved and new performance properties have found numerous applications in the automotive, aerospace, ship-making, chemical, electronics, steel, construction, and many other industries. Especially the formulations providing multiple functionalities to cured paint films are believed to dominate the coatings market in the near future. It has shifted the focus of research towards building sustainable coating recipes which can deliver multiple functionalities through applied films. The challenge to this exciting area of research arrives from the insufficient knowledge about structure-property correlations of nanocoating materials and their design complexity. Experimental efforts have been successful in developing certain types of nanopaints exhibiting improved properties. However, multifunctional nanopaint design optimality is extremely difficult to address if not impossible solely through experiments. In addition to this, the environmental implications and societal risks associated with this growing field of nanotechnology raise several questions related to its sustainable development. This research focuses on the study of a multiscale sustainable nanocoating design which can have the application from novel function envisioning and idea refinement point of view, to knowledge discovery and design solution derivation, and further to performance testing in industrial applications. The nanocoating design is studied using computational simulations of nano- to macro- scale models and sustainability assessment study over the life-cycle. Computational simulations aim at integrating top-down, goals/means, inductive systems engineering and bottom-up, cause and effect, deductive systems engineering approaches for material development. The in-silico paint resin system is a water-dispersible acrylic polymer with hydrophilic nanoparticles incorporated into it. The nano-scale atomistic and micro-scale coarse-grained (CG) level simulations are performed using molecular dynamics methodology to study several structural and morphological features such as effect of polymer molecular weight, polydispersity, rheology, nanoparticle volume fraction, size, shape and chemical nature on the bulk mechanical and self-cleaning properties of the coating film. At macro-scale, a paint spray system which is used for automotive coating application is studied by using CFD-based simulation methodology to generate crucial information about the effects of nanocoating technology on environmental emissions and coating film quality. The cradle-to-grave life-cycle based sustainability assessment study address all the critical issues related to economic benefits, environmental implications and societal effects of nanocoating technology through case studies of automotive coating systems. It is accomplished by identifying crucial correlations among measurable parameters at different stages and developing sustainability indicator matrices for analysis of each stage of life-cycle. The findings from the research can have great potential to draft useful conclusions in favor of future development of coating systems with novel functionalities and improved sustainability.

WebTOP: A 3D Interactive System for Teaching and Learning Optics

ERIC Educational Resources Information Center

Mzoughi, Taha; Herring, S. Davis; Foley, John T.; Morris, Matthew J.; Gilbert, Peter J.

2007-01-01

WebTOP is a three-dimensional, Web-based, interactive computer graphics system that helps instructors teach and students learn about waves and optics. Current subject areas include waves, geometrical optics, reflection and refraction, polarization, interference, diffraction, lasers, and scattering. Some of the topics covered are suited for…

How a "Top-Performing" Asian School System Formulates and Implements Policy: The Case of Singapore

ERIC Educational Resources Information Center

Tan, Cheng Yong; Dimmock, Clive

2014-01-01

This article analyses the paradox inherent in the "top-performing" yet tightly controlled Singapore education system. As government controls have increased in complexity, existing policymaking conceptual heuristics in accounting for centre-periphery relationships appear inadequate. It argues that more direct government control is being…

49 CFR 179.102-3 - Materials poisonous by inhalation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... top fitting protection system and nozzle capable of sustaining, without failure, a rollover accident... geometric center of the loaded tank car as a transverse vector. Failure is deemed to occur when the deformed... any top fitting in the case of an accident where any top fitting would be sheared off. The tank nozzle...

49 CFR 179.102-3 - Materials poisonous by inhalation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... top fitting protection system and nozzle capable of sustaining, without failure, a rollover accident... geometric center of the loaded tank car as a transverse vector. Failure is deemed to occur when the deformed... any top fitting in the case of an accident where any top fitting would be sheared off. The tank nozzle...

49 CFR 179.102-3 - Materials poisonous by inhalation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... top fitting protection system and nozzle capable of sustaining, without failure, a rollover accident... geometric center of the loaded tank car as a transverse vector. Failure is deemed to occur when the deformed... any top fitting in the case of an accident where any top fitting would be sheared off. The tank nozzle...

49 CFR 179.102-3 - Materials poisonous by inhalation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... top fitting protection system and nozzle capable of sustaining, without failure, a rollover accident... geometric center of the loaded tank car as a transverse vector. Failure is deemed to occur when the deformed... any top fitting in the case of an accident where any top fitting would be sheared off. The tank nozzle...

Passive cooling system for top entry liquid metal cooled nuclear reactors

DOEpatents

Boardman, Charles E.; Hunsbedt, Anstein; Hui, Marvin M.

1992-01-01

A liquid metal cooled nuclear fission reactor plant having a top entry loop joined satellite assembly with a passive auxiliary safety cooling system for removing residual heat resulting from fuel decay during shutdown, or heat produced during a mishap. This satellite type reactor plant is enhanced by a backup or secondary passive safety cooling system which augments the primary passive auxiliary cooling system when in operation, and replaces the primary cooling system when rendered inoperative.

The Atmospheric Infrared Sounder- An Overview

NASA Technical Reports Server (NTRS)

Larnbrigtsen, Bjorn; Fetzer, Eric; Lee, Sung-Yung; Irion, Fredrick; Hearty, Thomas; Gaiser, Steve; Pagano, Thomas; Aumann, Hartmut; Chahine, Moustafa

2004-01-01

The Atmospheric Infrared Sounder (AIRS) was launched in May 2002. Along with two companion microwave sensors, it forms the AIRS Sounding Suite. This system is the most advanced atmospheric sounding system to date, with measurement accuracies far surpassing those available on current weather satellites. The data products are calibrated radiances from all three sensors and a number of derived geophysical parameters, including vertical temperature and humidity profiles, surface temperature, cloud fraction, cIoud top pressure, and profiles of ozone. These products are generated under cloudy as well as clear conditions. An ongoing calibration validation effort has confirmed that the system is very accurate and stable, and many of the geophysical parameters have been validated. AIRS is in some cases more accurate than any other source and can therefore be difficult to validate, but this offers interesting new research opportunities. The applications for the AIRS products range from numerical weather prediction to atmospheric research - where the AIRS water vapor products near the surface and in the mid to upper troposphere will make it possible to characterize and model phenomena that are key for short-term atmospheric processes, such as weather patterns, to long-term processes, such as interannual cycles (e.g., El Nino) and climate change.

Sedimentology and lithostratigraphy of a late Wisconsinan outer shelf delta, research consortium boring in Main Pass Block 303, Mississippi delta area

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberts, H.H.; Bouma, A.H.; Coleman, J.M.

A 92 m continuous boring was collected in Main Pass Area, Block 303, to better understand deltaic sedimentation and facies architecture in relationship to glacio eustatic cycles. The boring was also used to calibrate sequence stratigraphy with lithology and chronostratigraphy. The boring spans six isotope stages, covering parts of the last three sea-level cycles. The basal part (92-81 m; glacial isotope Stage 6) is interpreted as a mudflow composed of a rapidly deposited shale with distorted bedding, gas-related structures, and C-13 depleted diagenetic carbonates. This glacial stage is overlain by transgressive systems tract shelf shales capped by a 4-m thickmore » nodular calcareous shale/shelly limestone, representing the interglacial isotope Stage 5 condensed section as well as part of an outer shelf high stand systems tract. Isotope Stage 4 (60-55 m), a lowstand, appears to be condensed or missing, according to benthic foraminifera and oxygen isotope data, possibly constituting a parasequence boundary. The ensuing early Stage 3 transgression (53-45 m) and maximum flooding surface at 43 m precede a distinct progradational deltaic event (43-18 m). There is no clear sedimentary record of the latter part of Stage 3. This midshelf delta has a fauna-poor, rapidly deposited prodelta shale at the base overlain by alternating thin clays, silts, and sands of the distal bar facies and topped by a thick distributary mouth bar sand with numerous layers of redistributed organics. The Stage 2 glacial maximum appears represented by an erosional contact between the fine deltaic sands and the coarse sandy and fine gravelly transgressive system tract channel deposits. There are about 3 m of Stage 1 bioturbated silts and shelly sands capping the section.« less

Biogeochemical cycling in terrestrial ecosystems of the Caatinga Biome.

PubMed

Menezes, R S C; Sampaio, E V S B; Giongo, V; Pérez-Marin, A M

2012-08-01

The biogeochemical cycles of C, N, P and water, the impacts of land use in the stocks and flows of these elements and how they can affect the structure and functioning of Caatinga were reviewed. About half of this biome is still covered by native secondary vegetation. Soils are deficient in nutrients, especially N and P. Average concentrations of total soil P and C in the top layer (0-20 cm) are 196 mg kg(-1) and 9.3 g kg(-1), corresponding to C stocks around 23 Mg ha(-1). Aboveground biomass of native vegetation varies from 30 to 50 Mg ha(-1), and average root biomass from 3 to 12 Mg ha(-1). Average annual productivities and biomass accumulation in different land use systems vary from 1 to 7 Mg ha(-1) year(-1). Biological atmospheric N2 fixation is estimated to vary from 3 to 11 kg N ha(-1) year-1 and 21 to 26 kg N ha(-1) year(-1) in mature and secondary Caatinga, respectively. The main processes responsible for nutrient and water losses are fire, soil erosion, runoff and harvest of crops and animal products. Projected climate changes in the future point to higher temperatures and rainfall decreases. In face of the high intrinsic variability, actions to increase sustainability should improve resilience and stability of the ecosystems. Land use systems based on perennial species, as opposed to annual species, may be more stable and resilient, thus more adequate to face future potential increases in climate variability. Long-term studies to investigate the potential of the native biodiversity or adapted exotic species to design sustainable land use systems should be encouraged.

Durable superhydrophobic surfaces made by intensely connecting a bipolar top layer to the substrate with a middle connecting layer.

PubMed

Zhi, Jinghui; Zhang, Li-Zhi

2017-08-30

This study reported a simple fabrication method for a durable superhydrophobic surface. The superhydrophobic top layer of the durable superhydrophobic surface was connected intensely to the substrate through a middle connecting layer. Glycidoxypropyltrimethoxysilane (KH-560) after hydrolysis was used to obtain a hydrophilic middle connecting layer. It could be adhered to the hydrophilic substrate by covalent bonds. Ring-open reaction with octadecylamine let the KH-560 middle layer form a net-like structure. The net-like sturcture would then encompass and station the silica particles that were used to form the coarse micro structures, intensely to increase the durability. The top hydrophobic layer with nano-structures was formed on the KH-560 middle layer. It was obtained by a bipolar nano-silica solution modified by hexamethyldisilazane (HMDS). This layer was connected to the middle layer intensely by the polar Si hydroxy groups, while the non-polar methyl groups on the surface, accompanied by the micro and nano structures, made the surface rather hydrophobic. The covalently interfacial interactions between the substrate and the middle layer, and between the middle layer and the top layer, strengthened the durability of the superhydrophobic surface. The abrasion test results showed that the superhydrophobic surface could bear 180 abrasion cycles on 1200 CW sandpaper under 2 kPa applied pressure.

[How management teams use information and control systems to manage hospitals].

PubMed

Naranjo-Gil, David

2016-01-01

To analyze the relationship between the characteristics of top management teams and the different use of management information and control systems (MICS) to implement policies that encourage cooperation and activity coordination in public hospitals. Data were collected through a questionnaire sent to each member of the top management teams of 231 Spanish public hospitals (chief executive director, medical director, nursing director and director for financial and social issues). A total of 457 valid questionnaires were returned, composing 86 full top management teams (37.23%). Top management team diversity was positively related to the interactive use of MICS. Management teams composed of younger members and members with longer service used MICS interactively. Top management teams with a predominantly clinical education and experience used MICS interactively, while top teams with a predominantly administrative education and experience used MICS diagnostically. The results also showed that cooperation and coordination in hospitals were positively related to the interactive use of MICS and were negatively related to the diagnostic use of MICS. The interactive use of MICS is an important mediator in the relationship between top team diversity and policies focused on hospital decentralization. Top management teams with diverse characteristics (e.g. age, length of service, education and experience) use management information interactively to enhance activity coordination and resource allocation in hospitals. Copyright © 2016 SESPAS. Published by Elsevier Espana. All rights reserved.

Stirling Microregenerators Fabricated and Tested

NASA Technical Reports Server (NTRS)

Moran, Matthew E.

2004-01-01

A mesoscale Stirling refrigerator patented by the NASA Glenn Research Center is currently under development. This refrigerator has a predicted efficiency of 30 percent of Carnot and potential uses in electronics, sensors, optical and radiofrequency systems, microarrays, and microsystems. The mesoscale Stirling refrigerator is most suited to volume-limited applications that require cooling below the ambient or sink temperature. Primary components of the planar device include two diaphragm actuators that replace the pistons found in traditional-scale Stirling machines and a microregenerator that stores and releases thermal energy to the working gas during the Stirling cycle. Diaphragms are used to eliminate frictional losses and bypass leakage concerns associated with pistons, while permitting reversal of the hot and cold sides of the device during operation to allow precise temperature control. Three candidate microregenerators were fabricated under NASA grants for initial evaluation: two constructed of porous ceramic, which were fabricated by Johns Hopkins Applied Physics Laboratory, and one made of multiple layers of nickel and photoresist, which was fabricated by Polar Thermal Technologies. The candidate regenerators are being tested by Johns Hopkins Applied Physics in a custom piezoelectric-actuated test apparatus designed to produce the Stirling refrigeration cycle. In parallel with the regenerator testing, Johns Hopkins is using deep reactive ion etching to fabricate electrostatically driven, comb-drive diaphragm actuators. These actuators will drive the Stirling cycle in the prototype device. The top photograph shows the porous ceramic microregenerators. Two microregenerators were fabricated with coarse pores and two with fine pores. The bottom photograph shows the test apparatus parts for evaluating the microregenerators, including the layered nickel-and-photoresist regenerator fabricated using LIGA techniques.

Thermal stress analysis of ceramic gas-path seal components for aircraft turbines

NASA Technical Reports Server (NTRS)

Kennedy, F. E.; Bill, R. C.

1979-01-01

Stress and temperature distributions were evaluated numerically for a blade-tip seal system proposed for gas turbine applications. The seal consists of an abradable ceramic layer on metallic backing with intermediate layers between the ceramic layer and metal substrate. The most severe stresses in the seal, as far as failure is concerned, are tensile stresses at the top of the ceramic layer and shear and normal stresses at the layer interfaces. All these stresses reach their maximum values during the deceleration phase of a test engine cycle. A parametric study was carried out to evaluate the influence of various design parameters on these critical stress values. The influences of material properties and geometric parameters of the ceramic, intermediate, and backing layers were investigated. After the parametric study was completed, a seal system was designed which incorporated materials with beneficial elastic and thermal properties in each layer of the seal. An analysis of the proposed seal design shows an appreciable decrease in the magnitude of the maximum critical stresses over those obtained with earlier configurations.

Statistical Analyses of Satellite Cloud Object Data from CERES. Part II; Tropical Convective Cloud Objects During 1998 El Nino and Validation of the Fixed Anvil Temperature Hypothesis

NASA Technical Reports Server (NTRS)

Xu, Kuan-Man; Wong, Takmeng; Wielicki, Bruce a.; Parker, Lindsay; Lin, Bing; Eitzen, Zachary A.; Branson, Mark

2006-01-01

Characteristics of tropical deep convective cloud objects observed over the tropical Pacific during January-August 1998 are examined using the Tropical Rainfall Measuring Mission/ Clouds and the Earth s Radiant Energy System single scanner footprint (SSF) data. These characteristics include the frequencies of occurrence and statistical distributions of cloud physical properties. Their variations with cloud-object size, sea surface temperature (SST), and satellite precessing cycle are analyzed in detail. A cloud object is defined as a contiguous patch of the Earth composed of satellite footprints within a single dominant cloud-system type. It is found that statistical distributions of cloud physical properties are significantly different among three size categories of cloud objects with equivalent diameters of 100 - 150 km (small), 150 - 300 km (medium), and > 300 km (large), respectively, except for the distributions of ice particle size. The distributions for the larger-size category of cloud objects are more skewed towards high SSTs, high cloud tops, low cloud-top temperature, large ice water path, high cloud optical depth, low outgoing longwave (LW) radiation, and high albedo than the smaller-size category. As SST varied from one satellite precessing cycle to another, the changes in macrophysical properties of cloud objects over the entire tropical Pacific were small for the large-size category of cloud objects, relative to those of the small- and medium-size categories. This result suggests that the fixed anvil temperature hypothesis of Hartmann and Larson may be valid for the large-size category. Combining with the result that a higher percentage of the large-size category of cloud objects occurs during higher SST subperiods, this implies that macrophysical properties of cloud objects would be less sensitive to further warming of the climate. On the other hand, when cloud objects are classified according to SSTs where large-scale dynamics plays important roles, statistical characteristics of cloud microphysical properties, optical depth and albedo are not sensitive to the SST, but those of cloud macrophysical properties are strongly dependent upon the SST. Frequency distributions of vertical velocity from the European Center for Medium-range Weather Forecasts model that is matched to each cloud object are used to interpret some of the findings in this study.

A User Oriented Review of the Literature on the Effects of Sleep Loss, Work-Rest Schedules, and Recovery on Performance

DTIC Science & Technology

1974-12-01

Martin , 0. E. and Alluisi, E. A., "Human Performance as a Function of the Work-Rest Cycle: A Review of Selected Studies," National Academy.of Sciences...WilKinson, R. T., "One Stress on Top of Another," New So0eety, 12 JOly 1972, 72-75 52. Wilkinson, R. T., "Sleep Deprivation-Eight Questions," MRC

Integrating Recycled Glass Cullet in Asphalt Roof Shingles to Mitigate Heat Island Effect

DTIC Science & Technology

2014-05-01

polymer, 39.3% bituminous composition, 57.5% trap rock dust stabilizer. Using recycled rubber, the formula is 3.2% elastomeric polymer, 37.2...and then rock or slag granules with similar gradation for the headlap granules. Ideal top surface materials are either igneous or metamorphic ...inherently opaque, and must be resistant to multiple heat-thaw cycles. The granules most widely used are crushed slate, basalt, and trap rock (Pagen

Top quark pair production and top quark properties at CDF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moon, Chang-Seong

2016-06-02

We present the most recent measurements of top quark pairs production and top quark properties in proton-antiproton collisions with center-of-mass energy of 1.96 TeV using CDF II detector at the Tevatron. The combination of top pair production cross section measurements and the direct measurement of top quark width are reported. The test of Standard Model predictions for top quark decaying intomore » $b$-quarks, performed by measuring the ratio $R$ between the top quark branching fraction to $b$-quark and the branching fraction to any type of down quark is shown. The extraction of the CKM matrix element $$|V_{tb}|$$ from the ratio $R$ is discussed. We also present the latest measurements on the forward-backward asymmetry ($$A_{FB}$$) in top anti-top quark production. With the full CDF Run II data set, the measurements are performed in top anti-top decaying to final states that contain one or two charged leptons (electrons or muons). In addition, we combine the results of the leptonic forward-backward asymmetry in $$t\\bar t$$ system between the two final states. All the results show deviations from the next-to-leading order (NLO) standard model (SM) calculation.« less

Cyclic photochemical re-growth of gold nanoparticles: Overcoming the mask-erosion limit during reactive ion etching on the nanoscale

PubMed Central

Seidenstücker, Axel; Plettl, Alfred; Ziemann, Paul

2013-01-01

Summary The basic idea of using hexagonally ordered arrays of Au nanoparticles (NP) on top of a given substrate as a mask for the subsequent anisotropic etching in order to fabricate correspondingly ordered arrays of nanopillars meets two serious obstacles: The position of the NP may change during the etching process and, thus, the primary pattern of the mask deteriorates or is completely lost. Furthermore, the NP are significantly eroded during etching and, consequently, the achievable pillar height is strongly restricted. The present work presents approaches on how to get around both problems. For this purpose, arrays of Au NPs (starting diameter 12 nm) are deposited on top of silica substrates by applying diblock copolymer micelle nanolithography (BCML). It is demonstrated that evaporated octadecyltrimethoxysilane (OTMS) layers act as stabilizer on the NP position, which allows for an increase of their size up to 50 nm by an electroless photochemical process. In this way, ordered arrays of silica nanopillars are obtained with maximum heights of 270 nm and aspect ratios of 5:1. Alternatively, the NP position can be fixed by a short etching step with negligible mask erosion followed by cycles of growing and reactive ion etching (RIE). In that case, each cycle is started by photochemically re-growing the Au NP mask and thereby completely compensating for the erosion due to the previous cycle. As a result of this mask repair method, arrays of silica nanopillar with heights up to 680 nm and aspect ratios of 10:1 are fabricated. Based on the given recipes, the approach can be applied to a variety of materials like silicon, silicon oxide, and silicon nitride. PMID:24367758

Longwave Band-by-band Cloud Radiative Effect and its Application in GCM Evaluation

NASA Technical Reports Server (NTRS)

Huang, Xianglei; Cole, Jason N. S.; He, Fei; Potter, Gerald L.; Oreopoulos, Lazaros; Lee, Dongmin; Suarez, Max; Loeb, Norman G.

2012-01-01

The cloud radiative effect (CRE) of each longwave (LW) absorption band of a GCM fs radiation code is uniquely valuable for GCM evaluation because (1) comparing band-by-band CRE avoids the compensating biases in the broadband CRE comparison and (2) the fractional contribution of each band to the LW broadband CRE (f(sub CRE)) is sensitive to cloud top height but largely insensitive to cloud fraction, presenting thus a diagnostic metric to separate the two macroscopic properties of clouds. Recent studies led by the first author have established methods to derive such band ]by ]band quantities from collocated AIRS and CERES observations. We present here a study that compares the observed band-by-band CRE over the tropical oceans with those simulated by three different atmospheric GCMs (GFDL AM2, NASA GEOS-5, and CCCma CanAM4) forced by observed SST. The models agree with observation on the annual ]mean LW broadband CRE over the tropical oceans within +/-1W/sq m. However, the differences among these three GCMs in some bands can be as large as or even larger than +/-1W/sq m. Observed seasonal cycles of f(sub CRE) in major bands are shown to be consistent with the seasonal cycle of cloud top pressure for both the amplitude and the phase. However, while the three simulated seasonal cycles of f(sub CRE) agree with observations on the phase, the amplitudes are underestimated. Simulated interannual anomalies from GFDL AM2 and CCCma CanAM4 are in phase with observed anomalies. The spatial distribution of f(sub CRE) highlights the discrepancies between models and observation over the low-cloud regions and the compensating biases from different bands.

Vertical profile of fog microphysics : a case study

NASA Astrophysics Data System (ADS)

Burnet, Frédéric; Brilouet, Pierre-Etienne; Mazoyer, Marie; Bourrianne, Thierry; Etcheberry, Jean-Michel; Gaillard, Brigitte; Legain, Dominique; Tzanos, Diane; Barrié, Joel; Barrau, Sébastien; Defoy, Stephan

2016-04-01

The occurrence and development of fogs result from the non-linear interaction of competing radiative, thermodynamic, microphysical and dynamical processes and the forecasting of their life cycle still remains a challenging issue. Several field campaigns have been carried out at the SIRTA observatory in the Paris suburb area (France). These experiments have shown that fog events exhibit large differences of the microphysical properties and various evolutions during their life cycle. To better understand relationships between the different processes and to validate numerical simulations it is necessary however to document the vertical profile of the fog microphysics. A CDP (Cloud Droplet Spectrometer) from DMT (Droplet Measurement Technology, Boulder, CO) has been modified to allow measurements of the droplet size distribution in fog layers with a tethered balloon. This instrumental set-up has been used during a field campaign during the winter 2013-214 in the Landes area in the South West of France. To validate the vertical profiles provided by the modified CDP, a mast was equipped with microphysical instruments at 2 altitude levels with an another CDP at 24 m and a Fog Monitor FM100 at 42 m. The instrumental set-up deployed during this campaign is presented. Data collected during a fog event that occurred during the night of 5-6 March 2014 are analysed. We show that microphysical properties such as droplet number concentration, LWC and mean droplet size, exhibit different time evolution during the fog life cycle depending on the altitude level. Droplet size distribution measurements are also investigated. They reveal sharp variations along the vertical close to the top of the fog layer. In addition it is shown that the shape of the size distributions at the top follows a time evolution typical of a quasi-adiabatic droplet growth.

Plasma-free atomic layer deposition of Ru thin films using H{sub 2} molecules as a nonoxidizing reactant

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lee, Seung-Joon; Kim, Soo-Hyun, E-mail: soohyun@ynu.ac.kr; Saito, Masayuki

2016-05-15

The ruthenium (Ru) thin films were grown by atomic layer deposition (ALD) using a sequential supply of dicarbonyl-bis(5-methyl-2,4-hexanediketonato) Ru(II) (C{sub 16}H{sub 22}O{sub 6}Ru) and H{sub 2} as a reactant at a substrate temperature of 250 °C. Deposition was possible using H{sub 2} molecules without a plasma by increasing the chamber pressure to above 10 Torr. Specifically, high-quality Ru films with a low resistivity of ∼40 μΩ cm and few amount of oxygen (∼1.2 at. %) were obtained under a chamber pressure of 300 Torr though the oxygen was contained in the precursor. Under the optimized conditions, self-limited film growth with regard to the precursormore » and reactant pulsing times was confirmed under elevated chamber pressures. The ALD-Ru process proposed in this study showed one of the highest growth rates of 0.12 nm/cycle on a thermally grown SiO{sub 2} substrate, as well as a very low number of incubation cycles (approximately 12 cycles). Cross-sectional view transmission electron microscopy showed that no interfacial oxide had formed during the deposition of the ALD-Ru films on a W surface using H{sub 2} molecules, whereas ∼7 nm thick interfacial oxide was formed when O{sub 2} molecules were used as a reactant. The step coverage of the ALD-Ru film onto very small-sized trenches (aspect ratio: ∼4.5 and the top opening size of 25 nm) and holes (aspect ratio: ∼40 and top opening size of 40 nm) was excellent (∼100%).« less

Effects of the Interception of Litterfall by the Understory on Carbon Cycling in Eucalyptus Plantations of South China

PubMed Central

Huang, Yuhui; Hui, Dafeng; Wen, Meili

2014-01-01

For the purposes of forest restoration, carbon (C) fixation, and economic improvement, eucalyptus (Eucalyptus urophylla) has been widely planted in South China. The understory of eucalyptus plantations is often occupied by a dense community of the fern Dicranopteris dichotoma, which intercepts tree canopy leaf litter before it reaches the ground. To understand the effects of this interception of litterfall on C cycling in eucalyptus plantations, we quantified the mass of intercepted litter and the influences of litterfall interception on litter decomposition and soil respiration. The total mass of E. urophylla litterfall collected on the understory was similar to that collected by the traditional litter trap method. All of the eucalyptus litterfall is intercepted by the D. dichotoma canopy. Of the litterfall that was intercepted by D. dichotoma, 20–40% and 60–80% was intercepted by the top (50–100 cm) and bottom (0–50 cm) of the understory canopy, respectively. Intercepted litterfall decomposed faster at the bottom of understory canopy (at the base of the plants) than at the top, and decomposition was slower on the soil surface in the absence of understory than on any location in the understory canopy. Soil respiration was highest when both the understory and litter were present and was lowest when both the understory and litter were absent. These results indicate that litterfall interception changed carbon flow between aboveground and belowground through litter decomposition and soil respiration, which changed carbon cycling in eucalyptus plantations. The effects of the understory on litter decomposition and soil respiration should be considered in ecosystem carbon models. PMID:24959853

ATM Expression Predicts Veliparib and Irinotecan Sensitivity in Gastric Cancer by Mediating P53-Independent Regulation of Cell Cycle and Apoptosis.

PubMed

Subhash, Vinod Vijay; Tan, Shi Hui; Yeo, Mei Shi; Yan, Fui Leng; Peethala, Praveen C; Liem, Natalia; Krishnan, Vaidehi; Yong, Wei Peng

2016-12-01

Identification of synthetically lethal cellular targets and synergistic drug combinations is important in cancer chemotherapy as they help to overcome treatment resistance and increase efficacy. The Ataxia Telangiectasia Mutated (ATM) kinase is a nuclear protein that plays a major role in the initiation of DNA repair signaling and cell-cycle check points during DNA damage. Although ATM was shown to be associated with poor prognosis in gastric cancer, its implications as a predictive biomarker for cancer chemotherapy remain unexplored. The present study evaluated ATM-induced synthetic lethality and its role in sensitization of gastric cancer cells to PARP and TOP1 inhibitors, veliparib (ABT-888) and irinotecan (CPT-11), respectively. ATM expression was detected in a panel of gastric cell lines, and the IC 50 against each inhibitors was determined. The combinatorial effect of ABT-888 and CPT-11 in gastric cancer cells was also determined both in vitro and in vivo ATM deficiency was found to be associated with enhanced sensitivity to ABT-888 and CPT-11 monotherapy, hence suggesting a mechanism of synthetic lethality. Cells with high ATM expression showed reduced sensitivity to monotherapy; however, they showed a higher therapeutic effect with ABT-888 and CPT-11 combinatorial therapy. Furthermore, ATM expression was shown to play a major role in cellular homeostasis by regulating cell-cycle progression and apoptosis in a P53-independent manner. The present study highlights the clinical utility of ATM expression as a predictive marker for sensitivity of gastric cancer cells to PARP and TOP1 inhibition and provides a deeper mechanistic insight into ATM-dependent regulation of cellular processes. Mol Cancer Ther; 15(12); 3087-96. ©2016 AACR. ©2016 American Association for Cancer Research.

Radiotherapy Treatment Planning for Testicular Seminoma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilder, Richard B., E-mail: richardbwilder@yahoo.com; Buyyounouski, Mark K.; Efstathiou, Jason A.

2012-07-15

Virtually all patients with Stage I testicular seminoma are cured regardless of postorchiectomy management. For patients treated with adjuvant radiotherapy, late toxicity is a major concern. However, toxicity may be limited by radiotherapy techniques that minimize radiation exposure of healthy normal tissues. This article is an evidence-based review that provides radiotherapy treatment planning recommendations for testicular seminoma. The minority of Stage I patients who choose adjuvant treatment over surveillance may be considered for (1) para-aortic irradiation to 20 Gy in 10 fractions, or (2) carboplatin chemotherapy consisting of area under the curve, AUC = 7 Multiplication-Sign 1-2 cycles. Two-dimensional radiotherapymore » based on bony anatomy is a simple and effective treatment for Stage IIA or IIB testicular seminoma. Centers with expertise in vascular and nodal anatomy may consider use of anteroposterior-posteroanterior fields based on three-dimensional conformal radiotherapy instead. For modified dog-leg fields delivering 20 Gy in 10 fractions, clinical studies support placement of the inferior border at the top of the acetabulum. Clinical and nodal mapping studies support placement of the superior border of all radiotherapy fields at the top of the T12 vertebral body. For Stage IIA and IIB patients, an anteroposterior-posteroanterior boost is then delivered to the adenopathy with a 2-cm margin to the block edge. The boost dose consists of 10 Gy in 5 fractions for Stage IIA and 16 Gy in 8 fractions for Stage IIB. Alternatively, bleomycin, etoposide, and cisplatin chemotherapy for 3 cycles or etoposide and cisplatin chemotherapy for 4 cycles may be delivered to Stage IIA or IIB patients (e.g., if they have a horseshoe kidney, inflammatory bowel disease, or a history of radiotherapy).« less

Development of a Geologic Exploration Model foe the Permo-Pennsylvanian Petroleum System in South-Central Montana

DOE Office of Scientific and Technical Information (OSTI.GOV)

David A. Lopez

2007-06-30

Eolian sands are the main Pennsylvanian Tensleep Sandstone reservoir rocks, and were deposited in a near-shore environment interbedded with near-shore marine and sabkha calcareous and dolomitic rocks. Within the Tensleep, numerous cycles are characterized by basal marine or sabkha calcareous sandstone or dolomitic sandstone overlain by porous and permeable eolian sandstone, which in turn is capped by marine sandstone. The cycles represent the interplay of near-shore marine, sabkha, and eolian environments. On the west side of the project area, both the lower and upper Tensleep are present and the total thickness reaches a maximum of about 240 ft. The lowermore » Tensleep is 100 to 120 ft thick and consists of a sequence of repeating cycles of limey shallow marine sandstone, sandy limestone, and sandy dolomite. The upper Tensleep is generally characterized by cycles of sandy limestone or dolomite, overlain by light-colored, eolian dune sandstone capped by marine limey sandstone. In the central and eastern parts of the project area, only the lower Tensleep is present, but here eolian sandstones are in cycles much like those in the west in the upper Tensleep. The lower Tensleep is quite variable in thickness, ranging from about 25 ft to over 200 ft. Oil accumulations in the Tensleep are best described as structurally modified paleostratigraphic accumulations. At Frannie Field, the irregular oil column can be explained by a post-Tensleep channel scour on the west flank of the anticline. On the Powder River Basin side of the project area, the Soap Creek and Lodge Grass Fields produce from the Permo-Pennsylvanian system. In these two fields, erosional remnants of eolian sandstone control the production, similar to the situation at Frannie Field. At Soap Creek the trap is enhanced by structural closure. In the Lodge Grass area, Tensleep oil is trapped in preserved dunes in the footwall of a Laramide reverse fault. Oil generation and migration was early. Two hypotheses have been presented: migration occurred (1) before mid-Jurassic erosion produced a major regional unconformity or (2) about 82 million years ago. Migration pre-Laramide occurred because oil in both the Bighorn Basin and the Powder River Basin are part of the same petroleum system. Geochemical analyses of oils from producing fields across the region show the oils are all similar and have the same source and generation history. No Phosphoria source rocks exist in the project area of south-central Montana, requiring that oil migrated from distant source areas, probably in central and southwestern Wyoming. Oil shows and production in the Tensleep are absent in the northern part of the project area. This appears to be controlled by the merging of the top of the Tensleep Sandstone and the Jurassic unconformity (top of the Triassic Chugwater Formation). There should be potential for the discovery of oil in Tensleep stratigraphic traps or combination traps everywhere south of the Jurassic-Pennsylvanian Isopach zero contour except where the Tensleep has been exposed by uplift and erosion. Known Tensleep fields in south-central Montana are generally small in area, which agrees with outcrop studies that show eolian dune sequences are generally quite small in lateral extent, on the order of 10 to 40 acres. Although existing fields are small in area, they are very productive; individual wells will probably make 300,000 to 500,000 barrels of oil. In the project area, hydrodynamic considerations are important. All the existing Tensleep fields have active water drives. In many cases, the reservoir pressure today is as it was when initially discovered. In areas of high structural complexity, such as the Lodge Grass-Crow Agency fault and the Lake Basin fault zone, significant structural closure may be necessary to trap oil because of the strong hydrodynamic influence exerted by the underlying Madison Formation aquifer.« less

Test Operations Procedure (TOP) 01-1-020 Tropical Regions Environmental Considerations

DTIC Science & Technology

2013-02-08

and Soldier systems tests. 1.3 Purpose. This is an overview TOP and is organized to provide background information on the humid tropical region...processes that foul materiel and interfere with equipment and systems under test. Military testing at present and in the future requires much greater...accordance with the Holdridge Life Zone Classification System18. This system is based on the theory that vegetation structure (type) is directly

Reorganization of neuronal circuits of the central olfactory system during postprandial sleep

PubMed Central

Yamaguchi, Masahiro; Manabe, Hiroyuki; Murata, Koshi; Mori, Kensaku

2013-01-01

Plastic changes in neuronal circuits often occur in association with specific behavioral states. In this review, we focus on an emerging view that neuronal circuits in the olfactory system are reorganized along the wake-sleep cycle. Olfaction is crucial to sustaining the animals' life, and odor-guided behaviors have to be newly acquired or updated to successfully cope with a changing odor world. It is therefore likely that neuronal circuits in the olfactory system are highly plastic and undergo repeated reorganization in daily life. A remarkably plastic feature of the olfactory system is that newly generated neurons are continually integrated into neuronal circuits of the olfactory bulb (OB) throughout life. New neurons in the OB undergo an extensive selection process, during which many are eliminated by apoptosis for the fine tuning of neuronal circuits. The life and death decision of new neurons occurs extensively during a short time window of sleep after food consumption (postprandial sleep), a typical daily olfactory behavior. We review recent studies that explain how olfactory information is transferred between the OB and the olfactory cortex (OC) along the course of the wake-sleep cycle. Olfactory sensory input is effectively transferred from the OB to the OC during waking, while synchronized top-down inputs from the OC to the OB are promoted during the slow-wave sleep. We discuss possible neuronal circuit mechanisms for the selection of new neurons in the OB, which involves the encoding of olfactory sensory inputs and memory trace formation during waking and internally generated activities in the OC and OB during subsequent sleep. The plastic changes in the OB and OC are well coordinated along the course of olfactory behavior during wakefulness and postbehavioral rest and sleep. We therefore propose that the olfactory system provides an excellent model in which to understand behavioral state-dependent plastic mechanisms of the neuronal circuits in the brain. PMID:23966911

AlGaAs top solar cell for mechanical attachment in a multi-junction tandem concentrator solar cell stack

NASA Technical Reports Server (NTRS)

Dinetta, L. C.; Hannon, M. H.; Cummings, J. R.; Mcneeley, J. B.; Barnett, Allen M.

1990-01-01

Free-standing, transparent, tunable bandgap AlxGa1-xAs top solar cells have been fabricated for mechanical attachment in a four terminal tandem stack solar cell. Evaluation of the device results has demonstrated 1.80 eV top solar cells with efficiencies of 18 percent (100 X, and AM0) which would yield stack efficiencies of 31 percent (100 X, AM0) with a silicon bottom cell. When fully developed, the AlxGa1-xAs/Si mechanically-stacked two-junction solar cell concentrator system can provide efficiencies of 36 percent (AM0, 100 X). AlxGa1-xAs top solar cells with bandgaps from 1.66 eV to 2.08 eV have been fabricated. Liquid phase epitaxy (LPE) growth techniques have been used and LPE has been found to yield superior AlxGa1-xAs material when compared to molecular beam epitaxy and metal-organic chemical vapor deposition. It is projected that stack assembly technology will be readily applicable to any mechanically stacked multijunction (MSMJ) system. Development of a wide bandgap top solar cell is the only feasible method for obtaining stack efficiencies greater than 40 percent at AM0. System efficiencies of greater than 40 percent can be realized when the AlGaAs top solar cell is used in a three solar cell mechanical stack.

Urban Impact at the Urban-Agricultural Interface in Madison, WI: an Ecosystem Modeling Approach

NASA Astrophysics Data System (ADS)

Logan, K. E.; Kucharik, C. J.; Schneider, A.

2009-12-01

Global population and the proportion of people living in urban areas both continue to grow while average urban density is decreasing worldwide. Because urban areas are often located in the most agriculturally productive lands, expansion of the built environment can cause sharp reductions in land available for cultivation. Conversion of land to urban use also significantly alters climate variables. Urban materials differ from natural land covers in terms of albedo, thermal properties, and permeability, altering energy and water cycles. Anthropogenic heat emissions also alter the energy balance in and around a city. Preliminary analysis of urban impacts around Madison, WI, a small city located in a thriving agricultural region, was performed using the National Land Cover Database (NLCD), MODIS albedo products, ground-based observations, and a simulation of urban expansion, within a geographic information system (GIS). Population of the county is expected to increase by 58% while urban density is projected to decrease by 49% between 1992 and 2030, reflecting projected worldwide patterns. Carbon stored in the top 25cm of soil was found to be over 2.5 times greater in remnant prairies than in croplands and was calculated to be even less in urban areas; projected urban development may thus lead to large losses in carbon storage. Albedo measurements also show a significant decrease with urban development. Projected urban expansion between 2001 and 2030 is expected to convert enough agricultural lands to urban areas to result in a loss of 247,000 tons of crop yield in Dane County alone, based on current yields. For a more complete analysis of these impacts, urban parameters are incorporated into a terrestrial ecosystem model known as Agro-IBIS. This approach allows for detailed comparison of energy balance and biogeochemical cycles between local crop systems, lawns, and impervious city surfaces. Changes in these important cycles, in soil carbon storage, and in crop productivity/yield for 1992 - 2001 and projected 2030 development around Madison, WI will be shown.

The impact of the diurnal cycle on the propagation of Madden-Julian Oscillation convection across the Maritime Continent

DOE PAGES

Hagos, Samson M.; Zhang, Chidong; Feng, Zhe; ...

2016-09-19

Influences of the diurnal cycle of convection on the propagation of the Madden-Julian Oscillation (MJO) across the Maritime Continent (MC) are examined using cloud-permitting regional model simulations and observations. A pair of ensembles of control (CONTROL) and no-diurnal cycle (NODC) simulations of the November 2011 MJO episode are performed. In the CONTROL simulations, the MJO signal is weakened as it propagates across the MC, with much of the convection stalling over the large islands of Sumatra and Borneo. In the NODC simulations, where the incoming shortwave radiation at the top of the atmosphere is maintained at its daily mean value,more » the MJO signal propagating across the MC is enhanced. Examination of the surface energy fluxes in the simulations indicates that in the presence of the diurnal cycle, surface downwelling shortwave radiation in CONTROL simulations is larger because clouds preferentially form in the afternoon. Furthermore, the diurnal co-variability of surface wind speed and skin temperature results in a larger sensible heat flux and a cooler land surface in CONTROL compared to NODC simulations. Here, an analysis of observations indicates that the modulation of the downwelling shortwave radiation at the surface by the diurnal cycle of cloudiness negatively projects on the MJO intraseasonal cycle and therefore disrupts the propagation of the MJO across the MC.« less

Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle.

PubMed

Pesavento, James J; Yang, Hongbo; Kelleher, Neil L; Mizzen, Craig A

2008-01-01

Methylation of histone H4 at lysine 20 (K20) has been implicated in transcriptional activation, gene silencing, heterochromatin formation, mitosis, and DNA repair. However, little is known about how this modification is regulated or how it contributes to these diverse processes. Metabolic labeling and top-down mass spectrometry reveal that newly synthesized H4 is progressively methylated at K20 during the G(2), M, and G(1) phases of the cell cycle in a process that is largely inescapable and irreversible. Approximately 98% of new H4 becomes dimethylated within two to three cell cycles, and K20 methylation turnover in vivo is undetectable. New H4 is methylated regardless of prior acetylation, and acetylation occurs predominantly on K20-dimethylated H4, refuting the hypothesis that K20 methylation antagonizes H4 acetylation and represses transcription epigenetically. Despite suggestions that it is required for normal mitosis and cell cycle progression, K20 methylation proceeds normally during colchicine treatment. Moreover, delays in PR-Set7 synthesis and K20 methylation which accompany altered cell cycle progression during sodium butyrate treatment appear to be secondary to histone hyperacetylation or other effects of butyrate since depletion of PR-Set7 did not affect cell cycle progression. Together, our data provide an unbiased perspective of the regulation and function of K20 methylation.

Race to Top Now Faces Acid Test

ERIC Educational Resources Information Center

Cavanagh, Sean

2010-01-01

With the conclusion of the second round of the federal Race to the Top competition, states across the country--winners and losers alike--are vowing to move forward with ambitious plans to reshape teacher-evaluation systems, fix struggling schools, revamp antiquated data systems, and make other changes aimed at raising student achievement. Yet…

High frequency peritidal cycles in the lower member of the Late Cretaceous (Turonian, Coniasian-Santonian) El Hefhuf Formation, Bahariya Oases, Western Desert, Egypt

NASA Astrophysics Data System (ADS)

Khalifa, M. A.; Tanner, Lawrence H.

2017-06-01

Carbonate lithofacies of the lower member of the El Hefhuf Formation (Turonian, Coniasian-Santonian) in the Bahariya Oases, Western Desert of Egypt comprise dolostone, burrowed dolostone, cherty dolostone, calcareous dedolostone, dolomitic quartzose lime-mudstone, and caliche. The dolostone and cherty dolostone formed in intertidal to supratidal environments, while dedolostone and caliche were formed during subaerial exposure. The dolomitic quartzose lime-mudstone was deposited in a restricted subtidal environment. Stable isotope analyses of the dolostone lithofacies are consistent with dolomitization by normal marine to evaporatively enriched dolomitizing fluids with only slight mixing of meteoric water. Therefore, dolomitization occurred in the intertidal and supratidal environments immediately following deposition. The dolostone and cherty dolostone lithofacies display pronounced cyclicity at the sub-meter scale, with individual cycles consisting of one (monolithic), two (diad) or at most three (triad) lithofacies. Most of all cycles show evidence of subaerial exposure at the top, such as brecciations, and many cycles are capped by calcareous palaeosol layers (caliche). In the absence of evidence for cycle periods at Milankovitch-scale frequencies, we reject orbital forcing as the cause of the cyclicity and suggest instead autocyclic depositional processes in the peritidal environment as the primary control on cyclicity, possibly modified by eustatic fluctuations at periods longer than the cycles recorded here. The significance of this study is to suggest formation of dolomite cycles due to high-frequency in sea level with intermittent subaerial exposure.

A top-down design methodology and its implementation for VCSEL-based optical links design

NASA Astrophysics Data System (ADS)

Li, Jiguang; Cao, Mingcui; Cai, Zilong

2005-01-01

In order to find the optimal design for a given specification of an optical communication link, an integrated simulation of electronic, optoelectronic, and optical components of a complete system is required. It is very important to be able to simulate at both system level and detailed model level. This kind of model is feasible due to the high potential of Verilog-AMS language. In this paper, we propose an effective top-down design methodology and employ it in the development of a complete VCSEL-based optical links simulation. The principle of top-down methodology is that the development would proceed from the system to device level. To design a hierarchical model for VCSEL based optical links, the design framework is organized in three levels of hierarchy. The models are developed, and implemented in Verilog-AMS. Therefore, the model parameters are fitted to measured data. A sample transient simulation demonstrates the functioning of our implementation. Suggestions for future directions in top-down methodology used for optoelectronic systems technology are also presented.

The Belle II imaging Time-of-Propagation (iTOP) detector

NASA Astrophysics Data System (ADS)

Fast, J.; Belle II Barrel Particle Identification Group

2017-12-01

High precision flavor physics measurements are an essential complement to the direct searches for new physics at the LHC ATLAS and CMS experiments. Such measurements will be performed using the upgraded Belle II detector that will take data at the SuperKEKB accelerator. With 40x the luminosity of KEKB, the detector systems must operate efficiently at much higher rates than the original Belle detector. A central element of the upgrade is the barrel particle identification system. Belle II has built and installed an imaging-Time-of-Propagation (iTOP) detector. The iTOP uses quartz optics as Cherenkov radiators. The photons are transported down the quartz bars via total internal reflection with a spherical mirror at the forward end to reflect photons to the backward end where they are imaged onto an array of segmented Micro-Channel Plate Photo-Multiplier Tubes (MCP-PMTs). The system is read out using giga-samples per second waveform sampling Application-Specific Integrated Circuits (ASICs). The combined timing and spatial distribution of the photons for each event are used to determine particle species. This paper provides an overview of the iTOP system.

Teamwork for Oversight of Processes and Systems (TOPS). Implementation guide for TOPS version 2.0, 10 August 1992

NASA Technical Reports Server (NTRS)

Strand, Albert A.; Jackson, Darryl J.

1992-01-01

As the nation redefines priorities to deal with a rapidly changing world order, both government and industry require new approaches for oversight of management systems, particularly for high technology products. Declining defense budgets will lead to significant reductions in government contract management personnel. Concurrently, defense contractors are reducing administrative and overhead staffing to control costs. These combined pressures require bold approaches for the oversight of management systems. In the Spring of 1991, the DPRO and TRW created a Process Action Team (PAT) to jointly prepare a Performance Based Management (PBM) system titled Teamwork for Oversight of Processes and Systems (TOPS). The primary goal is implementation of a performance based management system based on objective data to review critical TRW processes with an emphasis on continuous improvement. The processes are: Finance and Business Systems, Engineering and Manufacturing Systems, Quality Assurance, and Software Systems. The team established a number of goals: delivery of quality products to contractual terms and conditions; ensure that TRW management systems meet government guidance and good business practices; use of objective data to measure critical processes; elimination of wasteful/duplicative reviews and audits; emphasis on teamwork--all efforts must be perceived to add value by both sides and decisions are made by consensus; and synergy and the creation of a strong working trust between TRW and the DPRO. TOPS permits the adjustment of oversight resources when conditions change or when TRW systems performance indicate either an increase or decrease in surveillance is appropriate. Monthly Contractor Performance Assessments (CPA) are derived from a summary of supporting system level and process-level ratings obtained from objective process-level data. Tiered, objective, data-driven metrics are highly successful in achieving a cooperative and effective method of measuring performance. The teamwork-based culture developed by TOPS proved an unequaled success in removing adversarial relationships and creating an atmosphere of continuous improvement in quality processes at TRW. The new working relationship does not decrease the responsibility or authority of the DPRO to ensure contract compliance and it permits both parties to work more effectively to improve total quality and reduce cost. By emphasizing teamwork in developing a stronger approach to efficient management of the defense industrial base TOPS is a singular success.

Teamwork for Oversight of Processes and Systems (TOPS). Implementation guide for TOPS version 2.0, 10 August 1992

NASA Astrophysics Data System (ADS)

Strand, Albert A.; Jackson, Darryl J.

As the nation redefines priorities to deal with a rapidly changing world order, both government and industry require new approaches for oversight of management systems, particularly for high technology products. Declining defense budgets will lead to significant reductions in government contract management personnel. Concurrently, defense contractors are reducing administrative and overhead staffing to control costs. These combined pressures require bold approaches for the oversight of management systems. In the Spring of 1991, the DPRO and TRW created a Process Action Team (PAT) to jointly prepare a Performance Based Management (PBM) system titled Teamwork for Oversight of Processes and Systems (TOPS). The primary goal is implementation of a performance based management system based on objective data to review critical TRW processes with an emphasis on continuous improvement. The processes are: Finance and Business Systems, Engineering and Manufacturing Systems, Quality Assurance, and Software Systems. The team established a number of goals: delivery of quality products to contractual terms and conditions; ensure that TRW management systems meet government guidance and good business practices; use of objective data to measure critical processes; elimination of wasteful/duplicative reviews and audits; emphasis on teamwork--all efforts must be perceived to add value by both sides and decisions are made by consensus; and synergy and the creation of a strong working trust between TRW and the DPRO. TOPS permits the adjustment of oversight resources when conditions change or when TRW systems performance indicate either an increase or decrease in surveillance is appropriate. Monthly Contractor Performance Assessments (CPA) are derived from a summary of supporting system level and process-level ratings obtained from objective process-level data. Tiered, objective, data-driven metrics are highly successful in achieving a cooperative and effective method of measuring performance. The teamwork-based culture developed by TOPS proved an unequaled success in removing adversarial relationships and creating an atmosphere of continuous improvement in quality processes at TRW. The new working relationship does not decrease the responsibility or authority of the DPRO to ensure contract compliance and it permits both parties to work more effectively to improve total quality and reduce cost. By emphasizing teamwork in developing a stronger approach to efficient management of the defense industrial base TOPS is a singular success.

Spray generators for absorption refrigeration systems

DOEpatents

Sibley, Howard W.

1979-06-19

A spray generator for an absorption refrigeration system that includes a heat exchanger comprised of a multiplicity of variably spaced heat exchange tubes. The tubes are spaced close together near the top of the heat exchanger and spaced more widely apart near the bottom of the heat exchanger. Dilute absorbent solution is sprayed down through the heat exchanger. The close nesting of the tubes in the top portion of the heat exchanger retards liquid flow and aids heating of the solution. The wide spacing of the tubes in the lower section of the heat exchanger facilitate vapor flow out of the heat exchanger and eliminates liquid "blow-off". The top tubes are covered by a baffle to prevent the liquid solution from splashing out of the heat exchanger off of these top tubes.

Applying operations research to optimize a novel population management system for cancer screening.

PubMed

Zai, Adrian H; Kim, Seokjin; Kamis, Arnold; Hung, Ken; Ronquillo, Jeremiah G; Chueh, Henry C; Atlas, Steven J

2014-02-01

To optimize a new visit-independent, population-based cancer screening system (TopCare) by using operations research techniques to simulate changes in patient outreach staffing levels (delegates, navigators), modifications to user workflow within the information technology (IT) system, and changes in cancer screening recommendations. TopCare was modeled as a multiserver, multiphase queueing system. Simulation experiments implemented the queueing network model following a next-event time-advance mechanism, in which systematic adjustments were made to staffing levels, IT workflow settings, and cancer screening frequency in order to assess their impact on overdue screenings per patient. TopCare reduced the average number of overdue screenings per patient from 1.17 at inception to 0.86 during simulation to 0.23 at steady state. Increases in the workforce improved the effectiveness of TopCare. In particular, increasing the delegate or navigator staff level by one person improved screening completion rates by 1.3% or 12.2%, respectively. In contrast, changes in the amount of time a patient entry stays on delegate and navigator lists had little impact on overdue screenings. Finally, lengthening the screening interval increased efficiency within TopCare by decreasing overdue screenings at the patient level, resulting in a smaller number of overdue patients needing delegates for screening and a higher fraction of screenings completed by delegates. Simulating the impact of changes in staffing, system parameters, and clinical inputs on the effectiveness and efficiency of care can inform the allocation of limited resources in population management.

Cogeneration technology alternatives study. Volume 1: Summary report

NASA Technical Reports Server (NTRS)

1980-01-01

Data and information in the area of advanced energy conversion systems for industrial congeneration applications in the 1985-2000 time period was studied. Six current and thirty-one advanced energy conversion systems were defined and combined with appropriate balance-of-plant equipment. Twenty-six industrial processes were selected from among the high energy consuming industries to serve as a framework for the study. Each conversion system was analyzed as a cogenerator with each industrial plant. Fuel consumption, costs, and environmental intrusion were evaluated and compared to corresponding traditional values. Various cogeneration strategies were analyzed and both topping and bottoming (using industrial by-product heat) applications were included. The advanced energy conversion technologies indicated reduced fuel consumption, costs, and emissions. Typically fuel energy savings of 10 to 25 percent were predicted compared to traditional on-site furnaces and utility electricity. With the variety of industrial requirements, each advanced technology had attractive applications. Overall, fuel cells indicated the greatest fuel energy savings and emission reductions. Gas turbines and combined cycles indicated high overall annual cost savings. Steam turbines and gas turbines produced high estimated returns. In some applications, diesels were most efficient. The advanced technologies used coal-derived fuels, or coal with advanced fluid bed combustion or on-site gasification systems.

Theoretical modelling and optimization of bubble column dehumidifier for a solar driven humidification-dehumidification system

NASA Astrophysics Data System (ADS)

Ranjitha, P. Raj; Ratheesh, R.; Jayakumar, J. S.; Balakrishnan, Shankar

2018-02-01

Availability and utilization of energy and water are the top most global challenges being faced by the new millennium. At the present state water scarcity has become a global as well as a regional challenge. 40 % of world population faces water shortage. Challenge of water scarcity can be tackled only with increase in water supply beyond what is obtained from hydrological cycle. This can be achieved either by desalinating the sea water or by reusing the waste water. High energy requirement need to be overcome for either of the two processes. Of many desalination technologies, humidification dehumidification (HDH) technology powered by solar energy is widely accepted for small scale production. Detailed optimization studies on system have the potential to effectively utilize the solar energy for brackish water desalination. Dehumidification technology, specifically, require further study because the dehumidifier effectiveness control the energetic performance of the entire HDH system. The reason attributes to the high resistance involved to diffuse dilute vapor through air in a dehumidifier. The present work intends to optimize the design of a bubble column dehumidifier for a solar energy driven desalination process. Optimization is carried out using Matlab simulation. Design process will identify the unique needs of a bubble column dehumidifier in HDH system.

Critical Zone services as environmental assessment criteria in intensively managed landscapes

NASA Astrophysics Data System (ADS)

Richardson, Meredith; Kumar, Praveen

2017-06-01

The Critical Zone (CZ) includes the biophysical processes occurring from the top of the vegetation canopy to the weathering zone below the groundwater table. CZ services provide a measure for the goods and benefits derived from CZ processes. In intensively managed landscapes, cropland is altered through anthropogenic energy inputs to derive more productivity, as agricultural products, than would be possible under natural conditions. However, the actual costs of alterations to CZ functions within landscape profiles are unknown. Through comparisons of corn feed and corn-based ethanol, we show that valuation of these CZ services in monetary terms provides a more concrete tool for characterizing seemingly abstract environmental damages from agricultural production systems. Multiple models are combined to simulate the movement of nutrients throughout the soil system, enabling the measurement of agricultural anthropogenic impacts to the CZ's regulating services. Results indicate water quality and atmospheric stabilizing services, measured by soil carbon storage, carbon respiration, and nitrate leaching, among others, can cost more than double that of emissions estimated in previous studies. Energy efficiency in addition to environmental impact is assessed to demonstrate how the inclusion of CZ services is necessary in accounting for the entire life cycle of agricultural production systems. These results conclude that feed production systems are more energy efficient and less environmentally costly than corn-based ethanol.

MicroRNA-Related DNA Repair/Cell-Cycle Genes Independently Associated With Relapse After Radiation Therapy for Early Breast Cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gee, Harriet E., E-mail: harriet.gee@sydney.edu.au; The Chris O'Brien Lifehouse, Missenden Road, Camperdown, NSW; Central Clinical School, Sydney Medical School, University of Sydney, NSW

Purpose: Local recurrence and distant failure after adjuvant radiation therapy for breast cancer remain significant clinical problems, incompletely predicted by conventional clinicopathologic markers. We had previously identified microRNA-139-5p and microRNA-1274a as key regulators of breast cancer radiation response in vitro. The purpose of this study was to investigate standard clinicopathologic markers of local recurrence in a contemporary series and to establish whether putative target genes of microRNAs involved in DNA repair and cell cycle control could better predict radiation therapy response in vivo. Methods and Materials: With institutional ethics board approval, local recurrence was measured in a contemporary, prospectively collected series ofmore » 458 patients treated with radiation therapy after breast-conserving surgery. Additionally, independent publicly available mRNA/microRNA microarray expression datasets totaling >1000 early-stage breast cancer patients, treated with adjuvant radiation therapy, with >10 years of follow-up, were analyzed. The expression of putative microRNA target biomarkers—TOP2A, POLQ, RAD54L, SKP2, PLK2, and RAG1—were correlated with standard clinicopathologic variables using 2-sided nonparametric tests, and to local/distant relapse and survival using Kaplan-Meier and Cox regression analysis. Results: We found a low rate of isolated local recurrence (1.95%) in our modern series, and that few clinicopathologic variables (such as lymphovascular invasion) were significantly predictive. In multiple independent datasets (n>1000), however, high expression of RAD54L, TOP2A, POLQ, and SKP2 significantly correlated with local recurrence, survival, or both in univariate and multivariate analyses (P<.001). Low RAG1 expression significantly correlated with local recurrence (multivariate, P=.008). Additionally, RAD54L, SKP2, and PLK2 may be predictive, being prognostic in radiation therapy–treated patients but not in untreated matched control individuals (n=107; P<.05). Conclusions: Biomarkers of DNA repair and cell cycle control can identify patients at high risk of treatment failure in those receiving radiation therapy for early breast cancer in independent cohorts. These should be further investigated prospectively, especially TOP2A and SKP2, for which targeted therapies are available.« less