THE DARK HALO-SPHEROID CONSPIRACY AND THE ORIGIN OF ELLIPTICAL GALAXIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Remus, Rhea-Silvia; Burkert, Andreas; Dolag, Klaus

2013-04-01

Dynamical modeling and strong-lensing data indicate that the total density profiles of early-type galaxies are close to isothermal, i.e., {rho}{sub tot}{proportional_to}r {sup {gamma}} with {gamma} Almost-Equal-To -2. To understand the origin of this universal slope we study a set of simulated spheroids formed in isolated binary mergers as well as the formation within the cosmological framework. The total stellar plus dark matter density profiles can always be described by a power law with an index of {gamma} Almost-Equal-To -2.1 with a tendency toward steeper slopes for more compact, lower-mass ellipticals. In the binary mergers the amount of gas involved inmore » the merger determines the precise steepness of the slope. This agrees with results from the cosmological simulations where ellipticals with steeper slopes have a higher fraction of stars formed in situ. Each gas-poor merger event evolves the slope toward {gamma} {approx} -2, once this slope is reached further merger events do not change it anymore. All our ellipticals have flat intrinsic combined stellar and dark matter velocity dispersion profiles. We conclude that flat velocity dispersion profiles and total density distributions with a slope of {gamma} {approx} -2 for the combined system of stars and dark matter act as a natural attractor. The variety of complex formation histories as present in cosmological simulations, including major as well as minor merger events, is essential to generate the full range of observed density slopes seen for present-day elliptical galaxies.« less

Multiple neutral density measurements in the lower thermosphere with cold-cathode ionization gauges

NASA Astrophysics Data System (ADS)

Lehmacher, G. A.; Gaulden, T. M.; Larsen, M. F.; Craven, J. D.

2013-01-01

Cold-cathode ionization gauges were used for rocket-borne measurements of total neutral density and temperature in the aurorally forced lower thermosphere between 90 and 200 km. A commercial gauge was adapted as a low-cost instrument with a spherical antechamber for measurements in molecular flow conditions. Three roll-stabilized payloads on different trajectories each carried two instruments for measurements near the ram flow direction along the respective upleg and downleg segments of a flight path, and six density profiles were obtained within a period of 22 min covering spatial separations up to 200 km. The density profiles were integrated below 125 km to yield temperatures. The mean temperature structure was similar for all six profiles with two mesopause minima near 110 and 101 km, however, for the downleg profiles, the upper minimum was warmer and the lower minimum was colder by 20-30 K indicating significant variability over horizontal scales of 100-200 km. The upper temperature minimum coincided with maximum horizontal winds speeds, exceeding 170 m/s.

Investigations in the ionosphere by means of Kosmos 378. N(h) profiles and the temperature of the F region according to ground-based and satellite measurements above Khabarovsk

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mirmovich, E.G.; Shapiro, B.S.

1975-01-01

Simultaneous satellite measurements of electron density N/sub s/ and temperature (T/sub e/)/sub s/ at a height h/sub s/ above an observatory and ground-based observations are used to compute the total vertical electron density profiles N(h) and estimate the temperature of the ionospheric plasma. Four close time intervals after sunset were selected for analysis.

Effect of n-3 polyunsaturated fatty acids on the lipidic profile of healthy Mexican volunteers.

PubMed

Carvajal, O; Angulo, O

1997-01-01

The effect of n-3 polyunsaturated fatty acids on the serum lipid profile in a Mexican population was evaluated. Three g of salmon oil was the daily intake during four weeks. Total cholesterol, triglycerides, low density lipoproteins, high density lipoproteins and erythrocyte fatty acid composition were analyzed. The hypertriglyceridemic group showed a statistically significant (p < 0.05) reduction of triglycerides and significant (p < 0.01) elevation of high density lipoproteins. The hypercholesterolemic group reduced significantly the levels of cholesterol and triglycerides; high density lipoproteins were augmented by 11.6%. The hypolipidemic effect of n-3 polyunsaturated fatty acids was manifest in the Mexican volunteers under the conditions here evaluated.

Variation of D-region nitric-oxide density with solar activity and season at the dip equator

NASA Technical Reports Server (NTRS)

Chakrabarty, D. K.; Pakhomov, S. V.; Beig, G.

1989-01-01

To study the solar control on electron density (N sub e) in the equatorial D region, a program was initiated with Soviet collaboration in 1979. A total of 31 rockets were launched during the high solar activity period, and 47 rockets during the low solar activity period, from Thumba to measure the N sub e profiles. Analysis of the data shows that the average values of N sub e for the high solar activity period are higher by a factor of about 2 to 3 compared to the low solar activity values. It was found that a single nitric oxide density, (NO), profile cannot reproduce all the observed N sub e profiles. An attempt was made to reproduce theoretically the observed N sub e profiles by introducing variation in (NO) for the different solar activity periods and seasons.

Possible influence of the Kuramoto length in a photo-catalytic water splitting reaction revealed by Poisson-Nernst-Planck equations involving ionization in a weak electrolyte

NASA Astrophysics Data System (ADS)

Suzuki, Yohichi; Seki, Kazuhiko

2018-03-01

We studied ion concentration profiles and the charge density gradient caused by electrode reactions in weak electrolytes by using the Poisson-Nernst-Planck equations without assuming charge neutrality. In weak electrolytes, only a small fraction of molecules is ionized in bulk. Ion concentration profiles depend on not only ion transport but also the ionization of molecules. We considered the ionization of molecules and ion association in weak electrolytes and obtained analytical expressions for ion densities, electrostatic potential profiles, and ion currents. We found the case that the total ion density gradient was given by the Kuramoto length which characterized the distance over which an ion diffuses before association. The charge density gradient is characterized by the Debye length for 1:1 weak electrolytes. We discuss the role of these length scales for efficient water splitting reactions using photo-electrocatalytic electrodes.

Linear calculations of edge current driven kink modes with BOUT++ code

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, G. Q., E-mail: ligq@ipp.ac.cn; Xia, T. Y.; Lawrence Livermore National Laboratory, Livermore, California 94550

This work extends previous BOUT++ work to systematically study the impact of edge current density on edge localized modes, and to benchmark with the GATO and ELITE codes. Using the CORSICA code, a set of equilibria was generated with different edge current densities by keeping total current and pressure profile fixed. Based on these equilibria, the effects of the edge current density on the MHD instabilities were studied with the 3-field BOUT++ code. For the linear calculations, with increasing edge current density, the dominant modes are changed from intermediate-n and high-n ballooning modes to low-n kink modes, and the linearmore » growth rate becomes smaller. The edge current provides stabilizing effects on ballooning modes due to the increase of local shear at the outer mid-plane with the edge current. For edge kink modes, however, the edge current does not always provide a destabilizing effect; with increasing edge current, the linear growth rate first increases, and then decreases. In benchmark calculations for BOUT++ against the linear results with the GATO and ELITE codes, the vacuum model has important effects on the edge kink mode calculations. By setting a realistic density profile and Spitzer resistivity profile in the vacuum region, the resistivity was found to have a destabilizing effect on both the kink mode and on the ballooning mode. With diamagnetic effects included, the intermediate-n and high-n ballooning modes can be totally stabilized for finite edge current density.« less

Evaluation of Lipid Profile in Patients with Cherry Angioma: A Case-Control Study in Guilan, Iran.

PubMed

Darjani, Abbas; Rafiei, Rana; Shafaei, Sareh; Rafiei, Elahe; Eftekhari, Hojat; Alizade, Narges; Gharaei Nejad, Kaveh; Rafiee, Behnam; Najirad, Sara

2018-01-01

Cherry angioma is the most common type of acquired cutaneous vascular proliferation which would increase with aging due to some angiogenic factors but the exact pathogenesis is unknown. Usually angiogenic factors are synthesized in human body to compensate occlusive effects of atherogenic agents such as serum lipids. Our hypothesis was that increased levels of these angiogenic factors could be a trigger for development of cherry angioma. This study has been designed to compare frequency of dyslipidemia in subjects with and without cutaneous cherry angioma. In this case-control study, 122 cases with cherry angioma and 122 control subjects without cherry angioma were enrolled. Demographic characteristics, number of the cherry angioma lesions, and serum lipid profile were collected for all subjects. The data was analyzed using SPSS 18 software. Mean levels of the total cholesterol, triglyceride, low-density lipoprotein, and high-density lipoprotein were higher in patients with cherry angioma compared to control subjects in which differences were significant for total cholesterol, low-density lipoprotein, and triglyceride ( P < 0.05) but not for high-density lipoprotein level. Serum lipids may have a role in producing angiogenic factors and development of cherry angioma and it seems logical to evaluate lipid profile in these cases.

The density of dark matter in the Galactic bulge and implications for indirect detection

DOE PAGES

Hooper, Dan

2016-11-29

A recent study, making use of the number of horizontal branch stars observed in infrared photometric surveys and kinematic measurements of M-giant stars from the BRAVA survey, combined with N-body simulations of stellar populations, has presented a new determination of the dark matter mass within the bulge-bar region of the Milky Way. That study constrains the total mass within themore » $$\\pm 2.2 \\times \\pm 1.4 \\times \\pm 1.2$$ kpc volume of the bulge-bar region to be ($$1.84 \\pm 0.07) \\times 10^{10} \\, M_{\\odot}$$, of which 9-30% is made up of dark matter. Here, we use this result to constrain the the Milky Way's dark matter density profile, and discuss the implications for indirect dark matter searches. Furthermore uncertainties remain significant, these results favor dark matter distributions with a cusped density profile. For example, for a scale radius of 20 kpc and a local dark matter density of 0.4 GeV/cm$^3$, density profiles with an inner slope of 0.69 to 1.40 are favored, approximately centered around the standard NFW value. In contrast, profiles with large flat-density cores are disfavored by this information.« less

Lipid profile and thyroid hormone status in the last trimester of pregnancy in single-humped camels (Camelus dromedarius).

PubMed

Omidi, Arash; Sajedi, Zhila; Montazer Torbati, Mohammad Bagher; Ansari Nik, Hossein

2014-04-01

Changes in lipid metabolism have been shown to occur during pregnancy. The thyroid hormones affect lipid metabolism. The present study was carried out to find out whether the last trimester of pregnancy affects thyroid hormones, thyroid-stimulating hormone (TSH), lipid, and lipoprotein profile in healthy dromedary camels. Twenty clinical healthy dromedary camels aged between 4-5 years were divided into two equal groups: (1) pregnant camels in their last trimester of pregnancy and (2) non-pregnant age-matched controls. Thyroid function tests were carried out by measuring serum levels of TSH, free thyroxin (fT4), total thyroxin (T4), free triiodothyronine (fT3), and total triiodothyronine (T3) by commercially available radio immunoassay kits. Total cholesterol (TC), triglyceride (TG), and high-density lipoprotein (HDL) cholesterol were analyzed using enzymatic/spectrophotometric methods while low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein (VLDL), and total lipid (TL) were calculated using Friedewald's and Raylander's formula, respectively. Serum levels of TSH and thyroid hormones except fT4 did not show any significant difference between pregnant and non-pregnant camels. fT4 level was lower in the pregnant camels (P < 0.05). Serum levels of total cholesterol, triglyceride, total lipid, LDL cholesterol, HDL cholesterol, and VLDL did not show significant difference between pregnant and non-pregnant camels. All of these variables in pregnant camels were higher than non-pregnant. Based on the results of this study, the fetus load may not alter the thyroid status of the camel and the concentrations of thyroid hormones were not correlated with TSH and lipid profile levels in the healthy pregnant camels.

Fatty acid and cholesterol profiles and hypocholesterolemic, atherogenic, and thrombogenic indices of table eggs in the retail market.

PubMed

Attia, Youssef A; Al-Harthi, Mohammed A; Korish, Mohamed A; Shiboob, Mohamed M

2015-10-27

Eggs are an important source of food due to its favorable effects on human health derived from the protein, fats, minerals, vitamins and bioactive components. We studied the effects of source of eggs in the retail market on fatty acids, lipid profiles and antioxidant status in eggs. Eggs from four sources named A, B, C, and D in the retail market were collected to determine fatty acid, total lipid, and cholesterol profiles; hypocholesterolemic, atherogenic and thrombotic indices; antioxidant status (e.g., of malondialdehyde); and total antioxidant capacity in the whole edible parts of eggs (albumen + yolk) and egg yolk. Samples were collected four times and pooled over times to represent 5 and 10 samples per source for determinations of fatty acids and determinations of lipid profiles and antioxidant status, respectively. Fatty acid, total lipid, and cholesterol profiles; hypocholesterolemic, atherogenic and thrombotic indices; presence of malondialdehyde; and total antioxidant capacity in the whole edible parts of eggs and egg yolk showed significant differences (P ≥ 0.05) among different sources of eggs in retail market. Source D showed higher levels of saturated fatty acids (SFA) and linoleic and monounsaturated fatty acid (MUFA)/polyunsaturated fatty acid (PUFA) ratio but lower levels of MUFA and linolenic, arachidonic, eicosapentaeonic (EPA), decohexaenoic (DHA), and total ω9 fatty acids and lower unsaturated fatty acids (UFA)/SFA ratio. Similar trend was shown in fatty acids profiles of the whole edible parts of eggs. On the other hand, total cholesterol, low density lipoprotein (LDL), LDL/high density lipoprotein (HDL) ratio, and atherogenic and thrombogenic indices and total antioxidant capacity of source D were significantly higher than those of other source, but levels of hypocholesterolemic index, and malondialdehyde levels were lower for source D. Eggs in the retail market in Jeddah city, Saudi Arabia, from May to August 2015 showed a different pattern of fatty acid and cholesterol profiles; hypocholesterolemic, atherogenic, and thrombogenic indices; and antioxidant status, which might reflect the nutritional and husbandry practice of laying hens. This can affect the nutritional values of eggs, and hence, customer benefits, suggesting the need for standardization and quality control based on nutrient index values.

Ultrafast decay of hot phonons in an AlGaN/AlN/AlGaN/GaN camelback channel

NASA Astrophysics Data System (ADS)

Leach, J. H.; Wu, M.; Morkoç, H.; Liberis, J.; Šermukšnis, E.; Ramonas, M.; Matulionis, A.

2011-11-01

A bottleneck for heat dissipation from the channel of a GaN-based heterostructure field-effect transistor is treated in terms of the lifetime of nonequilibrium (hot) longitudinal optical phonons, which are responsible for additional scattering of electrons in the voltage-biased quasi-two-dimensional channel. The hot-phonon lifetime is measured for an Al0.33Ga0.67N/AlN/Al0.1Ga0.9N/GaN heterostructure where the mobile electrons are spread in a composite Al0.1Ga0.9N/GaN channel and form a camelback electron density profile at high electric fields. In accordance with plasmon-assisted hot-phonon decay, the parameter of importance for the lifetime is not the total charge in the channel (the electron sheet density) but rather the electron density profile. This is demonstrated by comparing two structures with equal sheet densities (1 × 1013 cm-2), but with different density profiles. The camelback channel profile exhibits a shorter hot-phonon lifetime of ˜270 fs as compared with ˜500 fs reported for a standard Al0.33Ga0.67N/AlN/GaN channel at low supplied power levels. When supplied power is sufficient to heat the electrons > 600 K, ultrafast decay of hot phonons is observed in the case of the composite channel structure. In this case, the electron density profile spreads to form a camelback profile, and hot-phonon lifetime reduces to ˜50 fs.

Blood lipid levels in a rural male population.

PubMed

Thelin, A; Stiernström, E L; Holmberg, S

2001-06-01

Farmers have a low risk for cardiovascular disease, which may be related to a favourable blood lipid profile. In order to study the blood lipid levels and evaluate the effect of other cardiovascular risk factors on the blood lipid profile, this cross-sectional study was made. A total of 1013 farmers and 769 non-farming rural men in nine different Swedish counties were examined, interviewed, and replied to questionnaires. The inter-relationships between different risk factors were analysed using a multivariate linear regression model. The farmers had a significantly more favourable blood lipid profile than the non-farmers although the total cholesterol levels were almost the same for the two groups. In the total study population there were significant positive relationships between total cholesterol level and body mass index (BMI), diastolic blood pressure and smoking. The high-density lipoprotein (HDL) level was positively related to physical workload and alcohol consumption, and negatively related to BMI, waist/hip ratio and smoking. Triglyceride levels showed a positive relationship to BMI, waist/hip ratio and blood pressure. Differences between farmers and other rural males were seen, especially with respect to the effect of physical activity and psychosocial factors. Among the farmers, a negative correlation between the Karasek-Theorell authority over work index and total cholesterol, the low-density lipoprotein (LDL)/HDL ratio and triglyceride levels was observed. This study indicated that diet is of minor significance for the blood lipid profile, whereas factors such as physical activity, body weight and the waist/hip ratio, smoking, alcohol consumption, and perhaps psychosocial working conditions are major independent factors affecting the blood lipid profile most prominently among farmers, but also among non-farming rural men.

Measurements of the structure and circulation of the stratosphere and mesosphere, 1971-2

NASA Technical Reports Server (NTRS)

Smith, W. S.; Theon, J. S.; Wright, D. U., Jr.; Ramsdale, D. J.; Horvath, J. J.

1974-01-01

Complete data from a total of 43 meteorological rocket soundings of the stratosphere and mesosphere conducted from Barrow, Alaska; Churchill, Canada; Wallops Island Va.; and Kourou, French Guiana are presented. These data consist of temperature, pressure, density, and wind profiles from 35 acoustic grenade soundings that cover the 30 to 90 km altitude range, and temperature, pressure, and density profiles from 8 pitot probe soundings that cover the 25 to 120 km altitude range. Errors for each of the 35 acoustic grenade soundings are also included.

Tracing the Metal-poor M31 Stellar Halo with Blue Horizontal Branch Stars

NASA Astrophysics Data System (ADS)

Williams, Benjamin F.; Dalcanton, Julianne J.; Bell, Eric F.; Gilbert, Karoline M.; Guhathakurta, Puragra; Dorman, Claire; Lauer, Tod R.; Seth, Anil C.; Kalirai, Jason S.; Rosenfield, Philip; Girardi, Leo

2015-03-01

We have analyzed new Hubble Space Telescope (HST)/Advanced Camera for Surveys and HST/WFC3 imaging in F475W and F814W of two previously unobserved fields along the M31 minor axis to confirm our previous constraints on the shape of M31's inner stellar halo. Both of these new data sets reach a depth of at least F814W <27 and clearly detect the blue horizontal branch (BHB) of the field as a distinct feature of the color-magnitude diagram. We measure the density of BHB stars and the ratio of BHB to red giant branch (RGB) stars in each field using techniques identical to our previous work. We find excellent agreement with our previous measurement of a power law for the 2D projected surface density with an index of 2.6-0.2+0.3 outside of 3 kpc, which flattens to α < 1.2 inside of 3 kpc. Our findings confirm our previous suggestion that the field BHB stars in M31 are part of the halo population. However, the total halo profile is now known to differ from this BHB profile, which suggests that we have isolated the metal-poor component. This component appears to have an unbroken power-law profile from 3-150 kpc but accounts for only about half of the total halo stellar mass. Discrepancies between the BHB density profile and other measurements of the inner halo are therefore likely due to the different profile of the metal-rich halo component, which is not only steeper than the profile of the metal-poor component, but also has a larger core radius. These profile differences also help to explain the large ratio of BHB/RGB stars in our observations.

Forming Disc Galaxies In Major Mergers: Radial Density Profiles And Angular Momentum

NASA Astrophysics Data System (ADS)

Peschken, Nicolas; Athanassoula, E.; Rodionov, S. A.; Lambert, J. C.

2017-06-01

In Athanassoula et al. (2016), we used high resolution N-body hydrodynamical simulations to model the major merger between two disc galaxies with a hot gaseous halo each, and showed that the remnant is a spiral galaxy. The two discs are destroyed by the collision, but after the merger, accretion from the surrounding gaseous halo allows the building of a new disc in the remnant galaxy. In Peschken et al. (2017), we used these simulations to study the radial surface density profiles of the remnant galaxies with downbending profiles (type II), i.e. composed of an inner and an outer exponential disc separated by a break. We analyzed the effect of angular momentum on these profiles, and found that the inner and outer disc scalelengths, as well as the break radius, all increase linearly with the total angular momentum of the initial merging system. Following the angular momentum redistribution in our simulations, we find that the disc angular momentum is acquired via accretion from the gaseous halo. Furthermore, high angular momentum systems give more angular momentum to their discs, which affects directly their radial density profile.

A Classical and a Relativistic Law of Motion for Spherical Supernovae

NASA Astrophysics Data System (ADS)

Zaninetti, Lorenzo

2014-11-01

In this paper we derive some first order differential equations which model the classical and the relativistic thin layer approximations. The circumstellar medium is assumed to follow a density profile of the Plummer type, the Lane-Emden (n = 5) type, or a power law. The first order differential equations are solved analytically, numerically, by a series expansion, or by recursion. The initial conditions are chosen in order to model the temporal evolution of SN 1993J over 10 yr and a smaller chi-squared is obtained for the Plummer case with η = 6. The stellar mass ejected by the SN progenitor prior to the explosion, expressed in solar mass, is identified with the total mass associated with the selected density profile and varies from 0.217 to 0.402 when the central number density is 107 particles per cubic centimeter. The FWHM of the three density profiles, which can be identified with the size of the pre-SN 1993J envelope, varies from 0.0071 pc to 0.0092 pc.

Rocket observations of the ionosphere during the eclipse of 26 February 1979

NASA Technical Reports Server (NTRS)

Mcinerney, M. K.; Smith, L. G.

1984-01-01

Electron density profiles and energetic particle fluxes were determined from two rockets launched, respectively, at the beginning and end of totality during the solar eclipse of 26 February 1979. These, and one other rocket at the same time of day on 24 February 1979, were launched from near Red Lake, Ontario. The electron density profile from 24 February shows the electron density to be normal above 110 km, to rocket apogee. Below 110 km, the electron density is enhanced, by an order of magnitude in the D region, compared with data from Wallops Island at the same solar zenith angle (63 deg). The enhancement is qualitatively explained by the large flux of field aligned energetic particles observed on the same rocket. During totality (on 26 February) the electron density above 110 km to rocket apogee is reduced by a factor of about three. Below 110 km, the electron density is much greater than observed during previous eclipses. The particle flux measured on the 26 February was an order of magnitude less than that on the 24 February but showed greater variability, particularly at the higher energies (100 keV). A feature of the particle flux is that, for the two rockets that were separated horizontally by 38 km while above the absorbing region, the variations are uncorrelated.

The Relationship between Ionospheric Slab Thickness and the Peak Density Height, hmF2

NASA Astrophysics Data System (ADS)

Meehan, J.; Sojka, J. J.

2017-12-01

The electron density profile is one of the most critical elements in the ionospheric modeling-related applications today. Ionosphere parameters, hmF2, the height of the peak density layer, and slab thickness, the ratio of the total electron content, TEC, to the peak density value, NmF2, are generally obtained from any global sounding observation network and are easily incorporated into models, theoretical or empirical, as numerical representations. Slab thickness is a convenient one-parameter summary of the electron density profile and can relate a variety of elements of interest that effect the overall electron profile shape, such as the neutral and ionospheric temperatures and gradients, the ionospheric composition, and dynamics. Using ISR data from the 2002 Millstone Hill ISR data campaign, we found, for the first time, slab thickness to be correlated to hmF2. For this, we introduce a new ionospheric index, k, which ultimately relates electron density parameters and can be a very useful tool for describing the topside ionosphere shape. Our study is an initial one location, one season, 30-day study, and future work is needed to verify the robustness of our claim. Generally, the ionospheric profile shape, requires knowledge of several ionospheric parameters: electron, ion and neutral temperatures, ion composition, electric fields, and neutral winds, and is dependent upon seasons, local time, location, and the level of solar and geomagnetic activity; however, with this new index, only readily-available, ionospheric density information is needed. Such information, as used in this study, is obtained from a bottomside electron density profile provided by an ionosonde, and TEC data provided by a local, collocated GPS receiver.

Fluids density functional theory and initializing molecular dynamics simulations of block copolymers

NASA Astrophysics Data System (ADS)

Brown, Jonathan R.; Seo, Youngmi; Maula, Tiara Ann D.; Hall, Lisa M.

2016-03-01

Classical, fluids density functional theory (fDFT), which can predict the equilibrium density profiles of polymeric systems, and coarse-grained molecular dynamics (MD) simulations, which are often used to show both structure and dynamics of soft materials, can be implemented using very similar bead-based polymer models. We aim to use fDFT and MD in tandem to examine the same system from these two points of view and take advantage of the different features of each methodology. Additionally, the density profiles resulting from fDFT calculations can be used to initialize the MD simulations in a close to equilibrated structure, speeding up the simulations. Here, we show how this method can be applied to study microphase separated states of both typical diblock and tapered diblock copolymers in which there is a region with a gradient in composition placed between the pure blocks. Both methods, applied at constant pressure, predict a decrease in total density as segregation strength or the length of the tapered region is increased. The predictions for the density profiles from fDFT and MD are similar across materials with a wide range of interfacial widths.

State Education Finance and Governance Profile: Mississippi

ERIC Educational Resources Information Center

Poulin, Nicole S.

2010-01-01

This article presents the state education finance and governance profile of Mississippi. Mississippians compose 0.95% of the total U.S. population, and the average density of the state is 60.7 people per square mile. In terms of education finance, the property tax is the sole form of local revenue for public education in Mississippi. In 1997, the…

Precision cosmology with baryons: non-radiative hydrodynamics of galaxy groups

NASA Astrophysics Data System (ADS)

Rabold, Manuel; Teyssier, Romain

2017-05-01

The effect of baryons on the matter power spectrum is likely to have an observable effect for future galaxy surveys, like Euclid or Large Synoptic Survey Telescope (LSST). As a first step towards a fully predictive theory, we investigate the effect of non-radiative hydrodynamics on the structure of galaxy groups sized haloes, which contribute the most to the weak-lensing power spectrum. We perform high-resolution (more than one million particles per halo and one kilo-parsec resolution) non-radiative hydrodynamical zoom-in simulations of a sample of 16 haloes, comparing the profiles to popular analytical models. We find that the total mass profile is well fitted by a Navarro, Frenk & White model, with parameters slightly modified from the dark matter only simulation. We also find that the Komatsu & Seljak hydrostatic solution provides a good fit to the gas profiles, with however significant deviations, arising from strong turbulent mixing in the core and from non-thermal, turbulent pressure support in the outskirts. The turbulent energy follows a shallow, rising linear profile with radius, and correlates with the halo formation time. Using only three main structural halo parameters as variables (total mass, concentration parameter and central gas density), we can predict, with an accuracy better than 20 per cent, the individual gas density and temperature profiles. For the average total mass profile, which is relevant for power spectrum calculations, we even reach an accuracy of 1 per cent. The robustness of these predictions has been tested against resolution effects, different types of initial conditions and hydrodynamical schemes.

Ghrelin and lipid levels in panic disorder before and after treatment and their relationship with agoraphobia.

PubMed

Gul, Isil Gogcegoz; Cumurcu, Birgul Elbozan; Karlidag, Rifat; Turkoz, Yusuf

2015-09-01

We aimed to evaluate serum ghrelin (GHR) levels and lipid profile in panic disorder (PD), with and without agoraphobia, and to compare these parameters before and after treatment. The GHR and lipid profiles were measured in blood samples taken from 31 PD patients with agoraphobia, 22 PD patients without agoraphobia, and 53 control group subjects. 23 of the 53 patients who were prescribed 20 to 40 mg/day paroxetine had continued treatment. The 23 patients who had continued treatment were measured again at the end of twelve weeks. The GHR and triglyceride (TRG), total cholesterol (Total-C), low-density lipoproteins (LDL-C), and very low-density lipoproteins (VLDL-C) levels were higher in the PD with agoraphobia group than the PD without agoraphobia and control groups. The 23 patients that had continued their treatment were re-evaluated, and the serum GHR, Total-C levels, and BMI after treatment were significantly decreased, compared to the values before treatment. There may be a pathophysiological relationship between the GHR and lipid profiles that interact with each other in PD. In fact, this relationship was more marked in PD with agoraphobia than in PD without agoraphobia.

Profiles of Ionospheric Storm-enhanced Density during the 17 March 2015 Great Storm

NASA Astrophysics Data System (ADS)

Liu, J.; Wang, W.; Burns, A. G.; Yue, X.; Zhang, S.; Zhang, Y.

2015-12-01

Ionospheric F2 region peak densities (NmF2) are expected to show a positive phase correlation with total electron content (TEC), and electron density is expected to have an anti-correlation with electron temperature near the ionospheric F2 peak. However, we show that, during the 17 March 2015 great storm, TEC and F2 region electron density peak height (hmF2) over Millstone Hill increased, but the F2 region electron density peak (NmF2) decreased significantly during the storm-enhanced density (SED) phase of the storm compared with the quiet-time ionosphere. This SED occurred where there was a negative ionospheric storm near the F2 peak and below it. The weak ionosphere below the F2 peak resulted in much reduced downward heat conduction for the electrons, trapping the heat in the topside. This, in turn, increased the topside scale height, so that, even though electron densities at the F2 peak were depleted, TEC increased in the SED. The depletion in NmF2 was probably caused by an increase in the density of the molecular neutrals, resulting in enhanced recombination. In addition, the storm-time topside ionospheric electron density profile was much closer to diffusive equilibrium than non-storm time profile because of less daytime plasma flow from the ionosphere to the plasmasphere.

Measurements of the structure and circulation of the stratosphere and mesosphere, 1970

NASA Technical Reports Server (NTRS)

Smith, W. S.; Theon, J. S.; Wright, D. U., Jr.; Casey, J. F.; Horvath, J. J.

1972-01-01

Complete data from a total of 26 meteorological rocket soundings of the stratosphere and mesosphere conducted from Barrow, Alaska; Churchill, Canada; and Wallops Island, Va., are presented. These data consist of temperature, pressure, density, and wind profiles from 16 acoustic grenade soundings that cover the 30- to 90-km altitude range, and temperature, pressure, and density profiles from 10 pitot probe soundings that cover the 25- to 120-km altitude range. Errors for each of the 16 grenade soundings are also included. No analysis of the meteorological significance of the data is attempted.

Determination of dislocation density by electron backscatter diffraction and X-ray line profile analysis in ferrous lath martensite

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berecz, Tibor, E-mail: berecz@eik.bme.hu; Jenei, Péter, E-mail: jenei@metal.elte.hu; Csóré, András, E-mail: csorean@gmail.com

2016-03-15

The microstructure and the dislocation density in as-quenched ferrous lath martensite were studied by different methods. The blocks, packets and variants formed due to martensitic transformation were identified and their sizes were determined by electron backscatter diffraction (EBSD). Concomitant transmission electron microscopy (TEM) investigation revealed that the laths contain subgrains with the size between 50 and 100 nm. A novel evaluation procedure of EBSD images was elaborated for the determination of the density and the space distribution of geometrically necessary dislocations from the misorientation distribution. The total dislocation density obtained by X-ray diffraction line profile analysis was in good agreementmore » with the value determined by EBSD, indicating that the majority of dislocations formed due to martensitic transformation during quenching are geometrically necessary dislocations.« less

Mangiferin supplementation improves serum lipid profiles in overweight patients with hyperlipidemia: a double-blind randomized controlled trial.

PubMed

Na, Lixin; Zhang, Qiao; Jiang, Shuo; Du, Shanshan; Zhang, Wei; Li, Ying; Sun, Changhao; Niu, Yucun

2015-05-19

Our previous studies have shown that mangiferin decreased serum triglycerides and free fatty acids (FFAs) by increasing FFAs oxidation in both animal and cell experiments. This study sought to evaluate the effects of mangiferin on serum lipid profiles in overweight patients with hyperlipidemia. Overweight patients with hyperlipidemia (serum triglyceride ≥ 1.70 mmol/L, and total cholesterol ≥ 5.2 mmol/L) were included in this double-blind randomized controlled trial. Participants were randomly allocated to groups, either receiving mangiferin (150 mg/day) or identical placebo for 12 weeks. The lipid profile and serum levels of mangiferin, glucose, L-carnitine, β-hydroxybutyrate, and acetoacetate were determined at baseline and 12 weeks. A total of 97 participants completed the trial. Compared with the placebo control, mangiferin supplementation significantly decreased the serum levels of triglycerides and FFAs, and insulin resistance index. Mangiferin supplementation also significantly increased the serum levels of mangiferin, high-density lipoprotein cholesterol, L-carnitine, β-hydroxybutyrate, and acetoacetate, and increased lipoprotein lipase activity. However, there were no differences in the serum levels of total cholesterol, low-density lipoprotein cholesterol, serum glucose, and insulin between groups. Mangiferin supplementation could improve serum lipid profiles by reducing serum triglycerides and FFAs in overweight patients with hyperlipidemia, partly due to the promotion of FFAs oxidation.

Mangiferin supplementation improves serum lipid profiles in overweight patients with hyperlipidemia: a double-blind randomized controlled trial

PubMed Central

Na, Lixin; Zhang, Qiao; Jiang, Shuo; Du, Shanshan; Zhang, Wei; Li, Ying; Sun, Changhao; Niu, Yucun

2015-01-01

Our previous studies have shown that mangiferin decreased serum triglycerides and free fatty acids (FFAs) by increasing FFAs oxidation in both animal and cell experiments. This study sought to evaluate the effects of mangiferin on serum lipid profiles in overweight patients with hyperlipidemia. Overweight patients with hyperlipidemia (serum triglyceride ≥ 1.70 mmol/L, and total cholesterol ≥ 5.2 mmol/L) were included in this double-blind randomized controlled trial. Participants were randomly allocated to groups, either receiving mangiferin (150 mg/day) or identical placebo for 12 weeks. The lipid profile and serum levels of mangiferin, glucose, L-carnitine, β-hydroxybutyrate, and acetoacetate were determined at baseline and 12 weeks. A total of 97 participants completed the trial. Compared with the placebo control, mangiferin supplementation significantly decreased the serum levels of triglycerides and FFAs, and insulin resistance index. Mangiferin supplementation also significantly increased the serum levels of mangiferin, high-density lipoprotein cholesterol, L-carnitine, β-hydroxybutyrate, and acetoacetate, and increased lipoprotein lipase activity. However, there were no differences in the serum levels of total cholesterol, low-density lipoprotein cholesterol, serum glucose, and insulin between groups. Mangiferin supplementation could improve serum lipid profiles by reducing serum triglycerides and FFAs in overweight patients with hyperlipidemia, partly due to the promotion of FFAs oxidation. PMID:25989216

[Effect of oral administration of ascorbic acid on insulin sensitivity and lipid profile in obese individuals].

PubMed

Martínez-Abundis, E; Pascoe-González, S; González-Ortiz, M; Mora-Martínez, J M; Cabrera-Pivaral, C E

2001-01-01

The aim of this study was to identify the effect of an oral ascorbic acid (AA) supplement on lipid profile and insulin sensitivity in obese people. A randomized double-blind clinical trial placebo controlled was performed in 16 obese male volunteers [body mass index (BMI) 30-40 kg/m2]. Eight received orally 1 g of AA daily for four weeks and the other eight volunteers received placebo by the same scheme and period of time. Before and after the pharmacological intervention were measured total cholesterol, high-density-lipoprotein (HDL) cholesterol, triglycerides, glucose, creatinine and uric acid. Low-density-lipoprotein (LDL) cholesterol and very-low-density-lipoprotein (VLDL) triglycerides were calculated using formulas. In order to assess insulin sensitivity before and after the intervention, the steady-state glucose (SSG) was calculated from the insulin suppression test modified with octreotide. There were not significant differences in clinical characteristics between both groups. Basal metabolic profile and SSG were similar between both groups. There were not significant differences in both groups between before and after the intervention in metabolic profile and insulin sensitivity. AA did not modify the lipid profile nor insulin sensitivity in the group of obese people studied.

Identification and validation of seven new loci showing differential DNA methylation related to serum lipid profile: an epigenome-wide approach. The REGICOR study

USDA-ARS?s Scientific Manuscript database

Lipid traits (total, low-density and high-density lipoprotein cholesterol, and triglycerides) are risk factors for cardiovascular disease. DNA methylation is not only an inherited but also modifiable epigenetic mark that has been related to cardiovascular risk factors. Our aim was to identify loci s...

Equatorial ozone characteristics as measured at Natal (5.9 deg S, 35.2 deg W)

NASA Technical Reports Server (NTRS)

Kirchhoff, V. W. J. H.; Hilsenrath, E.; Motta, A. G.; Sahai, Y.; Medrano-B, R. A.

1982-01-01

Ozone density profiles obtained through electrochemical concentration cell (ECC) sonde measurements at Natal were analyzed. Time variations, as expected, are small. Outstanding features of the data are tropospheric densities substantially higher than those measured at other stations, and also a total ozone content that is higher than the averages given by satellite measurements.

Calculation of nanodrop profile from fluid density distribution.

PubMed

Berim, Gersh O; Ruckenstein, Eli

2016-05-01

Two approaches are examined, which can be used to determine the drop profile from the fluid density distributions (FDDs) obtained on the basis of microscopic theories. For simplicity, only two-dimensional (cylindrical, or axisymmetrical) distributions are examined and it is assumed that the fluid is either in contact with a smooth solid or separated from the smooth solid by a lubricating liquid film. The first approach is based on the sharp-kink interface approximation in which the density of the liquid inside and the density of the vapor outside the drop are constant with the exception of the surface layer of the drop where the density is different from the above ones. In this case, the drop profile was calculated by minimizing the total potential energy of the system. The second approach is based on a nonuniform FDD obtained either by the density functional theory or molecular dynamics simulations. To determine the drop profile from such an FDD, which does not contain sharp interfaces, three procedures can be used. In the first two procedures, P1 and P2, the one-dimensional FDDs along straight lines which are parallel to the surface of the solid are extracted from the two-dimensional FDD. Each of those one-dimensional FDDs has a vapor-liquid interface at which the fluid density changes from vapor-like to liquid-like values. Procedure P1 uses the locations of the equimolar dividing surfaces for the one-dimensional FDDs as points of the drop profile. Procedure P2 is based on the assumption that the fluid density is constant on the surface of the drop, that density being selected either arbitrarily or as a fluid density at the location of the equimolar dividing surface for one of the one-dimensional FDDs employed in procedure P1. In the third procedure, P3, which is suggested for the first time in this paper, the one-dimensional FDDs are taken along the straight lines passing through a selected point inside the drop (radial line). Then, the drop profile is calculated like in procedure P1. It is shown, that procedure P3 provides a drop profile which is more reasonable than the other ones. Relationship of the discussed procedures to those used in image analysis is briefly discussed. Copyright © 2016 Elsevier B.V. All rights reserved.

Validation of COSMIC radio occultation electron density profiles by incoherent scatter radar data

NASA Astrophysics Data System (ADS)

Cherniak, Iurii; Zakharenkova, Irina

The COSMIC/FORMOSAT-3 is a joint US/Taiwan radio occultation mission consisting of six identical micro-satellites. Each microsatellite has a GPS Occultation Experiment payload to operate the ionospheric RO measurements. FS3/COSMIC data can make a positive impact on global ionosphere study providing essential information about height electron density distribu-tion. For correct using of the RO electron density profiles for geophysical analysis, modeling and other applications it is necessary to make validation of these data with electron density distributions obtained by another measurement techniques such as proven ground based facili-ties -ionosondes and IS radars. In fact as the ionosondes provide no direct information on the profile above the maximum electron density and the topside ionosonde profile is obtained by fitting a model to the peak electron density value, the COSMIC RO measurements can make an important contribution to the investigation of the topside part of the ionosphere. IS radars provide information about the whole electron density profile, so we can estimate the agreement of topside parts between two independent measurements. To validate the reliability of COS-MIC data we have used the ionospheric electron density profiles derived from IS radar located near Kharkiv, Ukraine (geographic coordinates: 49.6N, 36.3E, geomagnetic coordinates: 45.7N, 117.8E). The Kharkiv radar is a sole incoherent scatter facility on the middle latitudes of Eu-ropean region. The radar operates with 100-m zenith parabolic antenna at 158 MHz with peak transmitted power 2.0 MW. The Kharkiv IS radar is able to determine the heights-temporal distribution of ionosphere parameters in height range of 70-1500 km. At the ionosphere in-vestigation by incoherent scatter method there are directly measured the power spectrum (or autocorrelation function) of scattered signal. With using of rather complex procedure of the received signal processing it is possible to estimate the majority of the ionospheric parameters -density and kinetic temperature of electron and main ions, the plasma drift velocity and others. The comparison of RO reveals that usually COSMIC RO profiles are in a rather good agreement with ISR profiles both in the F2 layer peak electron density (NmF2) and the form of profiles. The coincidence of profiles is better in the cases when projection of the ray path of tangent points is closer to the ISR location. It is necessary to note that retrieved electron density profiles should not be interpreted as actual vertical profiles. The geographical location of the ray path tangent points at the top and at the bottom of a profile may differ by several hundred kilometers. So the spatial smearing of data takes place and RO technique represents an image of vertical and horizontal ionospheric structure. That is why the comparison with ground-based data has rather relative character. We derived quantitative parameters to char-acterize the differences of the compared profiles: the peak height difference, the relative peak density difference. Most of the compared profiles agree within error limits, depending on the accuracy of the occultation-and the radar-derived profiles. In general COSMIC RO profiles are in a good agreement with incoherent radar profiles both in the F2 layer peak electron density (NmF2) and the form of the profiles. The coincidence of COSMIC and incoherent radar pro-files is better in the cases when projection of the ray path tangent points is closer to the radar location. COSMIC measurements can be efficiently used to study the topside part of the iono-spheric electron density. To validate the reliability of the COSMIC ionospheric observations it must be done the big work on the analysis and statistical generalization of the huge data array (today the total number of ionospheric occultation is more than 2.300.000), but this technique is a very promising one to retrieve accurate profiles of the ionospheric electron density with ground-based measurements on a global scale. We acknowledge the Taiwan's National Space Organization (NSPO) and the University Corporation for Atmospheric Research (UCAR) for providing the COSMIC Data.

The Mass of Saturn's B ring from hidden density waves

NASA Astrophysics Data System (ADS)

Hedman, M. M.; Nicholson, P. D.

2015-12-01

The B ring is Saturn's brightest and most opaque ring, but many of its fundamental parameters, including its total mass, are not well constrained. Elsewhere in the rings, the best mass density estimates come from spiral waves driven by mean-motion resonances with Saturn's various moons, but such waves have been hard to find in the B ring. We have developed a new wavelet-based technique, for combining data from multiple stellar occultations that allows us to isolate the density wave signals from other ring structures. This method has been applied to 5 density waves using 17 occultations of the star gamma Crucis observed by the Visual and Infrared Mapping Spectrometer (VIMS) onboard the Cassini spacecraft. Two of these waves (generated by the Janus 2:1 and Mimas 5:2 Inner Lindblad Resonances) are visible in individual occultation profiles, but the other three wave signatures ( associated with the Janus 3:2, Enceladus 3:1 and Pandora 3:2 Inner Lindblad Resonances ) are not visible in individual profiles and can only be detected in the combined dataset. Estimates of the ring's surface mass density derived from these five waves fall between 40 and 140 g/cm^2. Surprisingly, these mass density estimates show no obvious correlation with the ring's optical depth. Furthermore, these data indicate that the total mass of the B ring is probably between one-third and two-thirds the mass of Saturn's moon Mimas.

Studies of the electron density in the highest occupied molecular orbitals of PH 3, PF 3 and P(CH 3) 3 by electron momentum spectroscopy and Hartree-Fock, MRSD-CI and DFT calculations

NASA Astrophysics Data System (ADS)

Rolke, J.; Brion, C. E.

1996-06-01

The spherically averaged momentum profiles for the highest occupied molecular orbitals of PF 3 and P(CH 3) 3 have been obtained by electron momentum spectroscopy. The measurements provide a stringent test of basis set effects and the quality of ab-initio methods in the description of these larger molecular systems. As in previous work on the methyl-substituted amines, intuitive arguments fail to predict the correct amount of s- and p-type contributions to the momentum profile while delocalized molecular orbital concepts provide a more adequate description of the HOMOs. The experimental momentum profiles have been compared with theoretical momentum profiles calculated at the level of the target Hartree-Fock approximation with a range of basis sets. New Hartree-Fock calculations are also presented for the HOMO of PH 3 and compared to previously published experimental and theoretical momentum profiles. The experimental momentum profiles have further been compared to calculations at the level of the target Kohn-Sham approximation using density functional theory with the local density approximation and also with gradient corrected (non-local) exchange correlation potentials. In addition, total energies and dipole moments have been calculated for all three molecules by the various theoretical methods and compared to experimental values. Calculated 'density difference maps' show the regions where the HOMO momentum and position electron densities of PF 3 and P(CH 3) 3 change relative to the corresponding HOMO density of PH 3. The results suggest that methyl groups have an electron-attracting effect (relative to H) on the HOMO charge density in trimethyl phosphines. These conclusions are supported by a consideration of dipole moments and the 31P NMR chemical shifts for PH 3, PF 3 and P(CH 3) 3.

Radiated Power and Impurity Concentrations in the EXTRAP-T2R Reversed-Field Pinch

NASA Astrophysics Data System (ADS)

Corre, Y.; Rachlew, E.; Cecconello, M.; Gravestijn, R. M.; Hedqvist, A.; Pégourié, B.; Schunke, B.; Stancalie, V.

2005-01-01

A numerical and experimental study of the impurity concentration and radiation in the EXTRAP-T2R device is reported. The experimental setup consists of an 8-chord bolometer system providing the plasma radiated power and a vacuum-ultraviolet spectrometer providing information on the plasma impurity content. The plasma emissivity profile as measured by the bolometric system is peaked in the plasma centre. A one dimensional Onion Skin Collisional-Radiative model (OSCR) has been developed to compute the density and radiation distributions of the main impurities. The observed centrally peaked emissivity profile can be reproduced by OSCR simulations only if finite particle confinement time and charge-exchange processes between plasma impurities and neutral hydrogen are taken into account. The neutral hydrogen density profile is computed with a recycling code. Simulations show that recycling on metal first wall such as in EXTRAP-T2R (stainless steel vacuum vessel and molybdenum limiters) is compatible with a rather high neutral hydrogen density in the plasma centre. Assuming an impurity concentration of 10% for oxygen and 3% for carbon compared with the electron density, the OSCR calculation including lines and continuum emission reproduces about 60% of the total radiated power with a similarly centrally peaked emissivity profile. The centrally peaked emissivity profile is due to low ionisation stages and strongly radiating species in the plasma core, mainly O4+ (Be-like) and C3+ Li-like.

Measurements of fast ion spatial dynamics during magnetic activity in the RFP

NASA Astrophysics Data System (ADS)

Goetz, J. A.; Anderson, J. K.; Bonofiglo, P.; Kim, J.; McConnell, R.; Magee, R. M.

2017-10-01

Fast ions in the RFP are only weakly affected by a stochastic magnetic field and behave nearly classically in concentration too low to excite Alfvenic activity. At high fast ion concentration sourced by H-NBI in 300kA RFP discharges, a substantial drop in core-localized high pitch fast ions is observed during bursts of coupled EPM and IAE (magnetic island-induced Alfven eigenmode) activity (100-200kHz) through neutral particle analysis. Sourcing instead fast deuterium with NBI, the DD fusion products can measure the dynamics of the fast ion density profile. Both a collimated neutron detector and a new 3MeV fusion proton detector loaned by TriAlpha Energy measure the fast ion density profile with 5cm spatial resolution and 100 μs temporal resolution. In D-NBI, the bursting EPM is excited at slightly lower frequency and the IAE activity is nearly absent, likely due to an isotope effect and loss of wave-particle interaction. In these cases, neutral particle analysis shows little change in the core-localized high pitch fast ion content, and the fusion product profile indicates little change in the fast ion density profile, leaving unexplained the mechanism removing EPM drive. We measure a substantial redistribution of the fast ion profile due to strong lower-frequency ( 30kHz) MHD activity that accompanies the current profile relaxation in the RFP. Profile flattening is strongest in low bulk density discharges, which often occur with a total increase in global neutron flux from acceleration of the beam ions. Work supported by US DoE.

High triglycerides and low high-density lipoprotein cholesterol lipid profile in rheumatoid arthritis: A potential link among inflammation, oxidative status, and dysfunctional high-density lipoprotein.

PubMed

Rodríguez-Carrio, Javier; Alperi-López, Mercedes; López, Patricia; López-Mejías, Raquel; Alonso-Castro, Sara; Abal, Francisco; Ballina-García, Francisco J; González-Gay, Miguel Á; Suárez, Ana

The interactions between inflammation and lipid profile in rheumatoid arthritis (RA) are poorly understood. The lipid profile study in RA has been biased toward lipoprotein levels, whereas those of triglycerides (TGs) and lipoprotein functionality have been underestimated. Since recent findings suggest a role for TG and TG-rich lipoproteins (TRL) on inflammation, we aimed to evaluate a combined lipid profile characterized by high TG and low high-density lipoprotein cholesterol levels (TG high HDL low ) in RA. Lipid profiles were analyzed in 113 RA patients, 113 healthy controls, and 27 dyslipemic subjects. Levels of inflammatory mediators, paraoxonase-1 (PON1) activity, and total antioxidant capacity were quantified in serum. PON1-rs662 status was evaluated by real-time polymerase chain reaction. The TG high HDL low profile was detected in 29/113 RA patients. Although no differences in prevalence compared with healthy controls or dyslipemic subjects were observed, this profile was associated with increased tumor necrosis factor α (P = .004), monocyte chemotactic protein (P = .004), interferon-gamma-inducible protein-10 (P = .018), and leptin (P < .001) serum levels in RA, where decreased PON1 activity and total antioxidant capacity were found. TG high HDL low prevalence was lower among anti-TNFα-treated patients (P = .004). When RA patients were stratified by PON1-rs662 status, these associations remained in the low-activity genotype (QQ). Finally, a poor clinical response on TNFα blockade was related to an increasing prevalence of the TG high HDL low profile over treatment (P = .021) and higher TRL levels at baseline (P = .042). The TG high HDL low profile is associated with systemic inflammation, decreased PON1 activity, and poor clinical outcome on TNFα blockade in RA, suggesting a role of TRL and HDL dysfunction as the missing link between inflammation and lipid profile. Copyright © 2017 National Lipid Association. Published by Elsevier Inc. All rights reserved.

THE EFFECTS OF ANGULAR MOMENTUM ON HALO PROFILES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lentz, Erik W; Rosenberg, Leslie J; Quinn, Thomas R, E-mail: lentze@phys.washington.edu, E-mail: ljrosenberg@phys.washington.edu, E-mail: trq@astro.washington.edu

2016-05-10

The near universality of DM halo density profiles provided by N -body simulations proved to be robust against changes in total mass density, power spectrum, and some forms of initial velocity dispersion. Here we study the effects of coherently spinning up an isolated DM-only progenitor on halo structure. Halos with spins within several standard deviations of the simulated mean ( λ ≲ 0.20) produce profiles with negligible deviations from the universal form. Only when the spin becomes quite large ( λ ≳ 0.20) do departures become evident. The angular momentum distribution also exhibits a near universal form, which is alsomore » independent of halo spin up to λ ≲ 0.20. A correlation between these epidemic profiles and the presence of a strong bar in the virialized halo is also observed. These bar structures bear resemblance to the radial orbit instability in the rotationless limit.« less

Evaluation of Inversion Methods Applied to Ionospheric ro Observations

NASA Astrophysics Data System (ADS)

Rios Caceres, Arq. Estela Alejandra; Rios, Victor Hugo; Guyot, Elia

The new technique of radio-occultation can be used to study the Earth's ionosphere. The retrieval processes of ionospheric profiling from radio occultation observations usually assume spherical symmetry of electron density distribution at the locality of occultation and use the Abel integral transform to invert the measured total electron content (TEC) values. This pa-per presents a set of ionospheric profiles obtained from SAC-C satellite with the Abel inversion technique. The effects of the ionosphere on the GPS signal during occultation, such as bending and scintillation, are examined. Electron density profiles are obtained using the Abel inversion technique. Ionospheric radio occultations are validated using vertical profiles of electron con-centration from inverted ionograms , obtained from ionosonde sounding in the vicinity of the occultation. Results indicate that the Abel transform works well in the mid-latitudes during the daytime, but is less accurate during the night-time.

Lipidemic profile of athletes and non-athletes with similar body fat.

PubMed

Petridou, Anatoli; Lazaridou, Despina; Mougios, Vassilis

2005-08-01

Although chronic exercise is generally believed to improve the lipidemic profile, it is not clear whether this is due to exercise training or to other determinants such as the usually low body fat of athletes. The aim of the present study was to compare the lipidemic profile of young lean athletes and non-athletes matched for percentage body fat. Fourteen endurance athletes and fourteen sedentary men participated in the study. Participants provided two blood samples at the beginning and end of a 7-d period, during which they recorded physical activity and food intake. Athletes had significantly higher energy expenditure and energy intake but not significantly different macronutrient composition of their diet from non-athletes. No significant differences were found in serum triacylglycerol, total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol concentrations between groups. These data suggest that athletes and non-athletes with similar body fat do not differ in their lipidemic profiles.

Distinct lipid/lipoprotein profiles and hormonal responsiveness in nine ethnic groups of postmenopausal Asian women: the Pan-Asia Menopause (PAM) study.

PubMed

Taechakraichana, N; Holinka, C F; Haines, C J; Subramaniam, R; Tian, X W; Ausmanas, M K

2007-06-01

Lipid/lipoprotein profiles, among other factors, are associated with risk of cardiovascular disease. Because cardiovascular disease varies in Asian countries, we hypothesized that lipid profiles differ in ethnic groups of postmenopausal Asian women. To add to the limited body of information currently available, we also investigated the effects of estrogen/progestin therapy on lipid/lipoprotein profiles in postmenopausal Asian women. The Pan-Asia Menopause (PAM) study was a prospective, randomized, double-blind clinical trial evaluating 1028 postmenopausal women at 22 investigational centers in 11 Asian countries/territories. Subjects were randomly assigned to one of three doses of continuous combined conjugated estrogens (CE)/medroxyprogesterone acetate (MPA): CE/MPA (in mg/day) = 0.625/2.5, 0.45/1.5 or 0.3/1.5. The treatment period, following baseline evaluations, consisted of six continuous 28-day cycles. Analysis of lipid profiles was a secondary objective of the PAM study. Total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), very low density cholesterol (VLDC-C), triglycerides and lipoprotein(a) were analyzed at a central laboratory by state-of-the-art methods. Mean concentrations of total cholesterol, LDL-C, VLDL-C and triglycerides differed significantly among the nine ethnic groups of postmenopausal women. This difference was independent of body mass index and age, two factors that also influenced lipid/lipoprotein profiles. Mean HDL-C concentrations also differed, but this difference was influenced by body mass index in a weak interaction. All three doses of CE/MPA significantly lowered total cholesterol. Treatment with the high and middle doses significantly lowered LDL-C, and increased HDL-C, VLDL-C and triglycerides. The high dose produced a significant decrease in lipoprotein(a). The different lipid/lipoprotein profiles in the nine ethnic groups of postmenopausal Asian women evaluated here suggest a relationship to differences in the prevalence of cardiovascular disease reported for different regions in Asia. However, the reported prevalence data on cardiovascular disease morbidity and mortality in the regions corresponding to the nine ethnic groups are insufficient to allow qualitative comparisons with the lipid profiles shown in our study. The lipid/lipoprotein changes in response to estrogen/progestin therapy observed here are consistent with those reported for Western women.

The effect of non-sphericity on mass and anisotropy measurements in dSph galaxies with Schwarzschild method

NASA Astrophysics Data System (ADS)

Kowalczyk, Klaudia; Łokas, Ewa L.; Valluri, Monica

2018-05-01

In our previous work we confirmed the reliability of the spherically symmetric Schwarzschild orbit-superposition method to recover the mass and velocity anisotropy profiles of spherical dwarf galaxies. Here, we investigate the effect of its application to intrinsically non-spherical objects. For this purpose we use a model of a dwarf spheroidal galaxy formed in a numerical simulation of a major merger of two discy dwarfs. The shape of the stellar component of the merger remnant is axisymmetric and prolate which allows us to identify and measure the bias caused by observing the spheroidal galaxy along different directions, especially the longest and shortest principal axis. The modelling is based on mock data generated from the remnant that are observationally available for dwarfs: projected positions and line-of-sight velocities of the stars. In order to obtain a reliable tool while keeping the number of parameters low we parametrize the total mass distribution as a radius-dependent mass-to-light ratio with just two free parameters we aim to constrain. Our study shows that if the total density profile is known, the true, radially increasing anisotropy profile can be well recovered for the observations along the longest axis whereas the data along the shortest axis lead to the inference of an incorrect, isotropic model. On the other hand, if the density profile is derived from the method as well, the anisotropy is always underestimated but the total mass profile is well recovered for the data along the shortest axis whereas for the longest axis the mass content is overestimated.

Serum lipid levels for a multicultural population in Auckland, New Zealand: results from the Diabetes Heart and Health Survey (DHAH) 2002-2003.

PubMed

Gentles, Dudley; Metcalf, Patricia; Dyall, Lorna; Scragg, Robert; Sundborn, Gerhard; Schaaf, David; Black, Peter N; Jackson, Rodney T

2007-11-09

To describe mean serum lipid concentrations for Maori, Pacific people (mostly of Samoan, Tongan, Niuean, or Cook Islands origin), and Others (mostly New Zealand-born Europeans), and to identify risk factors for an adverse lipid profile. A cross-sectional survey of adults aged between 35-74 years within the Auckland area. There were 1006 Maori, 996 Pacific people, and 2021 'Others' Fasting blood samples were collected from participants, and total cholesterol, high-density lipoproteins (HDL), low-density lipoproteins (LDL), and triglycerides were measured. Maori and Pacific people had similar mean serum total and LDL cholesterol levels but lower HDL levels and higher total to HDL cholesterol ratios compared to Others (adjusted for age and gender). Maori also had higher triglycerides than Others. High BMI and cigarette smoking were positively associated with unfavourable lipid profiles, while current alcohol drinking and vigorous leisure time activity were associated with increased HDL cholesterol and lower total to HDL cholesterol ratios. Over 90% of all ethnic groups had total cholesterol levels above currently accepted optimal levels (>4 mmol/L) and two-thirds were above 5 mmol/L. While 30% of Others had a total to HDL cholesterol ratio above the 'optimal' threshold of 4.5, 40% of Maori and 44% of pacific people were above this level. This is the first study to simultaneously assess lipid levels in Maori, Pacific people, and Others in one population-based study. Despite similar total and LDL cholesterol levels in all ethnic groups; overweight, obesity, and current cigarette smoking were the main risk factors for their adverse lipid profiles. Engaging in leisure-time activity and alcohol consumption (and not surprisingly lipid-lowering drugs) were associated with better lipid profiles. We confirm that the main lipid-related cardiovascular disease risk in Maori and Pacific people is due to their low HDL and high triglyceride levels.

Ursolic acid and luteolin-7-glucoside improve lipid profiles and increase liver glycogen content through glycogen synthase kinase-3.

PubMed

Azevedo, Marisa F; Camsari, Cagri; Sá, Carla M; Lima, Cristovao F; Fernandes-Ferreira, Manuel; Pereira-Wilson, Cristina

2010-06-01

In the present study, two phytochemicals - ursolic acid (UA) and luteolin-7-glucoside (L7G) - were assessed in vivo in healthy rats regarding effects on plasma glucose and lipid profile (total cholesterol, HDL and LDL), as well as liver glycogen content, in view of their importance in the aetiology of diabetes and associated complications. Both UA and L7G significantly decreased plasma glucose concentration. UA also significantly increased liver glycogen levels accompanied by phosphorylation of glycogen synthase kinase-3 (GSK3). The increase in glycogen deposition induced by UA (mediated by GSK3) could have contributed to the lower plasma glucose levels observed. Both compounds significantly lowered total plasma cholesterol and low-density lipoprotein levels, and, in addition, UA increased plasma high-density lipoprotein levels. Our results show that UA particularly may be useful in preventable strategies for people at risk of developing diabetes and associated cardiovascular complications by improving plasma glucose levels and lipid profile, as well as by promoting liver glycogen deposition.

Novel lipoprotein density profiling in healthy dogs of various breeds, healthy miniature schnauzers, and miniature schnauzers with hyperlipidemia

PubMed Central

2013-01-01

Background Despite the importance of abnormalities in lipoprotein metabolism in clinical canine medicine, the fact that most previously used methods for lipoprotein profiling are rather laborious and time-consuming has been a major obstacle to the wide clinical application and use of lipoprotein profiling in this species. The aim of the present study was to assess the feasibility of a continuous lipoprotein density profile (CLPDP) generated within a bismuth sodium ethylenediaminetetraacetic acid (NaBiEDTA) density gradient to characterize and compare the lipoprotein profiles of healthy dogs of various breeds, healthy Miniature Schnauzers, and Miniature Schnauzers with primary hypertriacylglycerolemia. A total of 35 healthy dogs of various breeds with serum triacylglycerol (TAG) and cholesterol concentrations within their respective reference intervals were selected for use as a reference population. Thirty-one Miniature Schnauzers with serum TAG and cholesterol concentrations within their respective reference intervals and 31 Miniature Schnauzers with hypertriacylglyceridemia were also included in the study. Results The results suggest that CLPDP using NaBiEDTA provides unique diagnostic information in addition to measurements of serum TAG and cholesterol concentrations and that it is a useful screening method for dogs with suspected lipoprotein metabolism disorders. Using the detailed and continuous density distribution information provided by the CLPDP, important differences in lipoprotein profiles can be detected even among dogs that have serum TAG and cholesterol concentrations within the reference interval. Miniature Schnauzers with serum TAG and cholesterol concentrations within the reference interval had significantly different lipoprotein profiles than dogs of various other breeds. In addition, it was further established that specific lipoprotein fractions are associated with hypertriacylglyceridemia in Miniature Schnauzers. Conclusions The results of the present study suggest that density gradient ultracentrifugation using NaBiEDTA is a useful screening method for the study of lipoprotein profiles in dogs. Therefore, this method could potentially be used for diagnostic purposes for the separation of dogs suspected of having lipoprotein abnormalities from healthy dogs. PMID:23497598

Slingshot mechanism for clusters: Gas density regulates star density in the Orion Nebula Cluster (M42)

NASA Astrophysics Data System (ADS)

Stutz, Amelia M.

2018-02-01

We characterize the stellar and gas volume density, potential, and gravitational field profiles in the central ∼0.5 pc of the Orion Nebula Cluster (ONC), the nearest embedded star cluster (or rather, protocluster) hosting massive star formation available for detailed observational scrutiny. We find that the stellar volume density is well characterized by a Plummer profile ρstars(r) = 5755 M⊙ pc- 3 (1 + (r/a)2)- 5/2, where a = 0.36 pc. The gas density follows a cylindrical power law ρgas(R) = 25.9 M⊙ pc- 3 (R/pc)- 1.775. The stellar density profile dominates over the gas density profile inside r ∼ 1 pc. The gravitational field is gas-dominated at all radii, but the contribution to the total field by the stars is nearly equal to that of the gas at r ∼ a. This fact alone demonstrates that the protocluster cannot be considered a gas-free system or a virialized system dominated by its own gravity. The stellar protocluster core is dynamically young, with an age of ∼2-3 Myr, a 1D velocity dispersion of σobs = 2.6 km s-1, and a crossing time of ∼0.55 Myr. This time-scale is almost identical to the gas filament oscillation time-scale estimated recently by Stutz & Gould. This provides strong evidence that the protocluster structure is regulated by the gas filament. The protocluster structure may be set by tidal forces due to the oscillating filamentary gas potential. Such forces could naturally suppress low density stellar structures on scales ≳ a. The analysis presented here leads to a new suggestion that clusters form by an analogue of the 'slingshot mechanism' previously proposed for stars.

Development of internal magnetic probe for current density profile measurement in Versatile Experiment Spherical Torus

NASA Astrophysics Data System (ADS)

Yang, J.; Lee, J. W.; Jung, B. K.; Chung, K. J.; Hwang, Y. S.

2014-11-01

An internal magnetic probe using Hall sensors to measure a current density profile directly with perturbation of less than 10% to the plasma current is successfully operated for the first time in Versatile Experiment Spherical Torus (VEST). An appropriate Hall sensor is chosen to produce sufficient signals for VEST magnetic field while maintaining the small size of 10 mm in outer diameter. Temperature around the Hall sensor in a typical VEST plasma is regulated by blown air of 2 bars. First measurement of 60 kA VEST ohmic discharge shows a reasonable agreement with the total plasma current measured by Rogowski coil in VEST.

Appraisal of Antihyperlipidemic Activities of Lentinus lepideus in Hypercholesterolemic Rats

PubMed Central

Yoon, Ki Nam; Lee, Jae Seong; Kim, Hye Young; Lee, Kyung Rim; Shin, Pyung Gyun; Cheong, Jong Chun; Yoo, Young Bok; Alam, Nuhu; Ha, Tai Moon

2011-01-01

The wild edible mushroom, Lentinus lepideus has recently been cultivated for commercial use in Korea. While the mushroom has been widely used for nutritional and medicinal purposes, the possible anti-hyperlipidemic action is unclear. The effects of dietary L. lepideus on plasma and feces biochemical and on the liver histological status were investigated in hypercholesterolemic rats. Six-wk-old female Sprague-Dawley albino rats were divided into three groups of 10 rats each. Biochemical and histological examinations were performed. A diet containing 5% L. lepideus fruiting bodies reduced plasma total cholesterol, triglyceride, low-density lipoprotein, total lipid, phospholipids, and the ratio of low-density to high-density lipoprotein. Body weight was reduced. The diet did not adversely affect plasma biochemical and enzyme profiles. L. lepideus reduced significantly plasma β- and pre-β-lipoprotein, while α-lipoprotein content was increased. A histological study of hepatic cells by conventional hematoxylin-eosin and oil red O staining revealed normal findings for mushroom-fed hypercholesterolemic rats. The present study suggests that a diet supplemented with L. lepideus can provide health benefits by acting on the atherogenic lipid profile in hypercholesterolemic rats. PMID:22783117

Radio range measurements of coronal electron densities at 13 and 3.6 centimeter wavelengths during the 1988 solar conjunction of Voyager 2

NASA Technical Reports Server (NTRS)

Krisher, T. P.; Anderson, J. D.; Morabito, D. D.; Asmar, S. W.; Borutzki, S. E.; Delitsky, M. L.; Densmore, A. C.; Eshe, P. M.; Lewis, G. D.; Maurer, M. J.

1991-01-01

Radio range measurements of total solar plasma delay obtained during the solar conjunction of the Voyager 2 spacecraft in December 1988, which occurred near solar maximum activity in the 11 yr cycle are reported. The radio range measurements were generated by the Deep Space Network at two wavelengths on the downlink from the spacecraft: 3.6 and 13 cm. A direct measurement of the integrated electron density along the ray path between the earth stations and the spacecraft was obtained by differencing the range at the two wavelengths. Coronal electron density profiles have been derived during ingress and egress of the ray path, which approached the sun to within 5 solar radii. At 10 solar radii, the derived density profiles yield 34079 + or - 611/cu cm on ingress and 49688 + or - 983/cu cm on egress. These density levels are significantly higher than observed near previous solar maxima.

Mean state densities, temperatures and winds during the MAC/SINE and MAC/EPSILON campaigns

NASA Technical Reports Server (NTRS)

Luebken, F.-J.; Von Zahn, U.; Manson, A.; Meek, C.; Hoppe, U.-P.; Schmidlin, F. J.

1990-01-01

Two field campaigns were conducted, primarily in northern Norway, in the summer and late autumn of 1987; these yielded a total of 41 in situ temperature profiles and 67 in situ wind profiles. Simultaneously, ground-based measurements were conducted of OH temperatures and sodium lidar temperatures for 85 and 104 hours, respectively. The summer campaign's mean temperature profile exhibited major deviations from the CIRA (1986) reference atmosphere; the differences between this model and the observations are less pronounced in the autumn. Both the summer and autumn mean wind profiles were in general agreement with the CIRA model.

CLASH: Weak-lensing shear-and-magnification analysis of 20 galaxy clusters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Umetsu, Keiichi; Czakon, Nicole; Medezinski, Elinor

2014-11-10

We present a joint shear-and-magnification weak-lensing analysis of a sample of 16 X-ray-regular and 4 high-magnification galaxy clusters at 0.19 ≲ z ≲ 0.69 selected from the Cluster Lensing And Supernova survey with Hubble (CLASH). Our analysis uses wide-field multi-color imaging, taken primarily with Suprime-Cam on the Subaru Telescope. From a stacked-shear-only analysis of the X-ray-selected subsample, we detect the ensemble-averaged lensing signal with a total signal-to-noise ratio of ≅ 25 in the radial range of 200-3500 kpc h {sup –1}, providing integrated constraints on the halo profile shape and concentration-mass relation. The stacked tangential-shear signal is well described bymore » a family of standard density profiles predicted for dark-matter-dominated halos in gravitational equilibrium, namely, the Navarro-Frenk-White (NFW), truncated variants of NFW, and Einasto models. For the NFW model, we measure a mean concentration of c{sub 200c}=4.01{sub −0.32}{sup +0.35} at an effective halo mass of M{sub 200c}=1.34{sub −0.09}{sup +0.10}×10{sup 15} M{sub ⊙}. We show that this is in excellent agreement with Λ cold dark matter (ΛCDM) predictions when the CLASH X-ray selection function and projection effects are taken into account. The best-fit Einasto shape parameter is α{sub E}=0.191{sub −0.068}{sup +0.071}, which is consistent with the NFW-equivalent Einasto parameter of ∼0.18. We reconstruct projected mass density profiles of all CLASH clusters from a joint likelihood analysis of shear-and-magnification data and measure cluster masses at several characteristic radii assuming an NFW density profile. We also derive an ensemble-averaged total projected mass profile of the X-ray-selected subsample by stacking their individual mass profiles. The stacked total mass profile, constrained by the shear+magnification data, is shown to be consistent with our shear-based halo-model predictions, including the effects of surrounding large-scale structure as a two-halo term, establishing further consistency in the context of the ΛCDM model.« less

The co-evolution of total density profiles and central dark matter fractions in simulated early-type galaxies

NASA Astrophysics Data System (ADS)

Remus, Rhea-Silvia; Dolag, Klaus; Naab, Thorsten; Burkert, Andreas; Hirschmann, Michaela; Hoffmann, Tadziu L.; Johansson, Peter H.

2017-01-01

We present evidence from cosmological hydrodynamical simulations for a co-evolution of the slope of the total (dark and stellar) mass density profile, γtot, and the dark matter fraction within the half-mass radius, fDM, in early-type galaxies. The relation can be described as γtot = A fDM + B for all systems at all redshifts. The trend is set by the decreasing importance of gas dissipation towards lower redshifts and for more massive systems. Early-type galaxies are smaller, more concentrated, have lower fDM and steeper γtot at high redshifts and at lower masses for a given redshift; fDM and γtot are good indicators for growth by `dry' merging. The values for A and B change distinctively for different feedback models, and this relation can be used as a test for such models. A similar correlation exists between γtot and the stellar mass surface density Σ*. A model with weak stellar feedback and feedback from black holes is in best agreement with observations. All simulations, independent of the assumed feedback model, predict steeper γtot and lower fDM at higher redshifts. While the latter is in agreement with the observed trends, the former is in conflict with lensing observations, which indicate constant or decreasing γtot. This discrepancy is shown to be artificial: the observed trends can be reproduced from the simulations using observational methodology to calculate the total density slopes.

A three-dimensional geophysical model of the crust in the Barents Sea region: Model construction and basement characterization

USGS Publications Warehouse

Ritzmann, O.; Maercklin, N.; Inge, Faleide J.; Bungum, H.; Mooney, W.D.; Detweiler, S.T.

2007-01-01

BARENTS50, a new 3-D geophysical model of the crust in the Barents Sea Region has been developed by the University of Oslo, NORSAR and the U.S. Geological Survey. The target region comprises northern Norway and Finland, parts of the Kola Peninsula and the East European lowlands. Novaya Zemlya, the Kara Sea and Franz-Josef Land terminate the region to the east, while the Norwegian-Greenland Sea marks the western boundary. In total, 680 1-D seismic velocity profiles were compiled, mostly by sampling 2-D seismic velocity transects, from seismic refraction profiles. Seismic reflection data in the western Barents Sea were further used for density modelling and subsequent density-to-velocity conversion. Velocities from these profiles were binned into two sedimentary and three crystalline crustal layers. The first step of the compilation comprised the layer-wise interpolation of the velocities and thicknesses. Within the different geological provinces of the study region, linear relationships between the thickness of the sedimentary rocks and the thickness of the remaining crystalline crust are observed. We therefore, used the separately compiled (area-wide) sediment thickness data to adjust the total crystalline crustal thickness according to the total sedimentary thickness where no constraints from 1-D velocity profiles existed. The BARENTS50 model is based on an equidistant hexagonal grid with a node spacing of 50 km. The P-wave velocity model was used for gravity modelling to obtain 3-D density structure. A better fit to the observed gravity was achieved using a grid search algorithm which focussed on the density contrast of the sediment-basement interface. An improvement compared to older geophysical models is the high resolution of 50 km. Velocity transects through the 3-D model illustrate geological features of the European Arctic. The possible petrology of the crystalline basement in western and eastern Barents Sea is discussed on the basis of the observed seismic velocity structure. The BARENTS50 model is available at http://www.norsar.no/seismology/barents3d/. ?? 2007 The Authors Journal compilation ?? 2007 RAS.

Effects of Apple Consumption on Lipid Profile of Hyperlipidemic and Overweight Men

PubMed Central

Vafa, Mohammad Reza; Haghighatjoo, Elham; Shidfar, Farzad; Afshari, Shirin; Gohari, Mahmood Reza; Ziaee, Amir

2011-01-01

Objectives: Fruits and vegetables may be beneficial on lipid profile of hyperlipidemic subjects. The present study was aimed to verify the effect of golden delicious apple on Lipid Profile in hyperlipidemic and overweight men. Methods: Forty six hyperlipidemic and overweight men were randomly divided into two groups. Intervention group received 300g golden delicious apple per day for 8 weeks. Control group had the regular dietary regimen for the same period of time. Blood samples were analyzed for serum triglycerides (TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), very low density lipoprotein-cholesterol (VLDL), apolipoprotein B (Apo B), lipoprotein a (Lp a) and LDL/HDL ratio at baseline and after intervention. Results: Total polyphenols and fibers were 485 mg/kg and 4.03 g/100g in fresh apple respectively. After 8 weeks, significant statistical differences were observed considering the TG and VLDL levels between two groups, but no significant differences were observed regarding TC, LDL-C, HDL-C, Apo (B), Lp (a) and LDL/HDL ratio. Conclusions: Consumption of Golden delicious apple may be increased serum TG and VLDL in hyperlipidemic and overweight men. We need more studies to assay the effect of apple consumption on serum TC, LDL-C, HDL-C, Apo (B), Lp (a) and LDL/HDL ratio. PMID:21603015

The dynamics of z ~ 1 clusters of galaxies from the GCLASS survey

NASA Astrophysics Data System (ADS)

Biviano, A.; van der Burg, R. F. J.; Muzzin, A.; Sartoris, B.; Wilson, G.; Yee, H. K. C.

2016-10-01

Context. The dynamics of clusters of galaxies and its evolution provide information on their formation and growth, on the nature of dark matter and on the evolution of the baryonic components. Poor observational constraints exist so far on the dynamics of clusters at redshift z > 0.8. Aims: We aim to constrain the internal dynamics of clusters of galaxies at redshift z ~ 1, namely their mass profile M(r), velocity anisotropy profile β(r), and pseudo-phase-space density profiles Q(r) and Qr(r), obtained from the ratio between the mass density profile and the third power of the (total and, respectively, radial) velocity dispersion profiles of cluster galaxies. Methods: We used the spectroscopic and photometric data-set of 10 clusters at 0.87 < z < 1.34 from the Gemini Cluster Astrophysics Spectroscopic Survey (GCLASS). We determined the individual cluster masses from their velocity dispersions, then stack the clusters in projected phase-space. We investigated the internal dynamics of this stack cluster, using the spatial and velocity distribution of its member galaxies. We determined the stack cluster M(r) using the MAMPOSSt method, and its β(r) by direct inversion of the Jeans equation. The procedures used to determine the two aforementioned profiles also allowed us to determine Q(r) and Qr(r). Results: Several M(r) models are statistically acceptable for the stack cluster (Burkert, Einasto, Hernquist, NFW). The stack cluster total mass concentration, c ≡ r200/r-2 = 4.0-0.6+1.0, is in agreement with theoretical expectations. The total mass distribution is less concentrated than both the cluster stellar-mass and the cluster galaxies distributions. The stack cluster β(r) indicates that galaxy orbits are isotropic near the cluster center and become increasingly radially elongated with increasing cluster-centric distance. Passive and star-forming galaxies have similar β(r). The observed β(r) is similar to that of dark matter particles in simulated cosmological halos. Q(r) and Qr(r) are almost power-law relations with slopes similar to those predicted from numerical simulations of dark matter halos. Conclusions: Comparing our results with those obtained for lower-redshift clusters, we conclude that the evolution of the concentration-total mass relation and pseudo-phase-space density profiles agree with the expectations from ΛCDM cosmological simulations. The fact that Q(r) and Qr(r) already follow the theoretical expectations in z ~ 1 clusters suggest these profiles are the result of rapid dynamical relaxation processes, such as violent relaxation. The different concentrations of the total and stellar mass distribution, and their subsequent evolution, can be explained by merging processes of central galaxies leading to the formation of the brightest cluster galaxy. The orbits of passive cluster galaxies appear to become more isotropic with time, while those of star-forming galaxies do not evolve, presumably because star-formation is quenched on a shorter timescale than that required for orbital isotropization.

Phase mixing of Alfvén waves in axisymmetric non-reflective magnetic plasma configurations

NASA Astrophysics Data System (ADS)

Petrukhin, N. S.; Ruderman, M. S.; Shurgalina, E. G.

2018-02-01

We study damping of phase-mixed Alfvén waves propagating in non-reflective axisymmetric magnetic plasma configurations. We derive the general equation describing the attenuation of the Alfvén wave amplitude. Then we applied the general theory to a particular case with the exponentially divergent magnetic field lines. The condition that the configuration is non-reflective determines the variation of the plasma density along the magnetic field lines. The density profiles exponentially decreasing with the height are not among non-reflective density profiles. However, we managed to find non-reflective profiles that fairly well approximate exponentially decreasing density. We calculate the variation of the total wave energy flux with the height for various values of shear viscosity. We found that to have a substantial amount of wave energy dissipated at the lower corona, one needs to increase shear viscosity by seven orders of magnitude in comparison with the value given by the classical plasma theory. An important result that we obtained is that the efficiency of the wave damping strongly depends on the density variation with the height. The stronger the density decrease, the weaker the wave damping is. On the basis of this result, we suggested a physical explanation of the phenomenon of the enhanced wave damping in equilibrium configurations with exponentially diverging magnetic field lines.

Using Satellite Radio-Sounding Data to Investigate Variations in the Earth's Topside Ionosphere Electron Density Profiles in the Polar Regions

NASA Astrophysics Data System (ADS)

Detweiler, L. G.; Glocer, A.; Benson, R. F.; Fung, S. F.

2016-12-01

In order to investigate and understand the role that different drivers play on the electron density altitude profile in the topside ionosphere of the polar regions, we used satellite radio-sounding data collected during the 1960s, 1970s, and 1980s to construct a series of graphs of electron density as a function of altitude and solar zenith angle. These data were gathered by the swept-frequency topside sounders from four of the satellites from the International Satellites for Ionospheric Studies (ISIS) program: Alouette 1 and 2, and ISIS 1 and 2, and were obtained from the NASA Space Physics Data Facility. In order to control for phenomenon known to effect electron density, we restricted our data set to data collected during a specific DST range (between -10 and 40 nT), and roughly constant solar radio flux values (between 40 and 90 W*m-2*Hz-1). To look at the effect of electron precipitation, we examine two separate cases, one above an invariant latitude of 60°, which includes precipitation, and one above 75°, which excludes precipitation. Under these restrictions we gathered a total of 407,500 altitude, solar zenith angle, and electron density data pairs. We then sorted these data pairs into bins of altitude and solar zenith angle, and present graphs of the medians of these binned data. We then fit our binned data to an exponential function representing hydrostatic equilibrium in the ionosphere presented in Kitamura et. al [2011]. We present graphs which show how well this best fit equation fits our data. Our results clearly show the strong dependence of electron density with respect to solar zenith angle, and demonstrates that electron precipitation can also influence the electron density profile, particularly on the nightside. We also examine how seasonal effects, via differences in the neutral thermosphere, can affect the electron density profiles. This study provides a climatological picture of what drives the topside electron density profile in the polar regions, and could be useful in future studies for model validation.

Analytic H I-to-H2 Photodissociation Transition Profiles

NASA Astrophysics Data System (ADS)

Bialy, Shmuel; Sternberg, Amiel

2016-05-01

We present a simple analytic procedure for generating atomic (H I) to molecular ({{{H}}}2) density profiles for optically thick hydrogen gas clouds illuminated by far-ultraviolet radiation fields. Our procedure is based on the analytic theory for the structure of one-dimensional H I/{{{H}}}2 photon-dominated regions, presented by Sternberg et al. Depth-dependent atomic and molecular density fractions may be computed for arbitrary gas density, far-ultraviolet field intensity, and the metallicity-dependent H2 formation rate coefficient, and dust absorption cross section in the Lyman-Werner photodissociation band. We use our procedure to generate a set of {{H}} {{I}}{-}{to}{-}{{{H}}}2 transition profiles for a wide range of conditions, from the weak- to strong-field limits, and from super-solar down to low metallicities. We show that if presented as functions of dust optical depth, the {{H}} {{I}} and {{{H}}}2 density profiles depend primarily on the Sternberg “α G parameter” (dimensionless) that determines the dust optical depth associated with the total photodissociated {{H}} {{I}} column. We derive a universal analytic formula for the {{H}} {{I}}{-}{to}{-}{{{H}}}2 transition points as a function of just α G. Our formula will be useful for interpreting emission-line observations of H I/{{{H}}}2 interfaces, for estimating star formation thresholds, and for sub-grid components in hydrodynamics simulations.

Core or Cusps: The Central Dark Matter Profile of a Strong Lensing Cluster with a Bright Central Image at Redshift 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collett, Thomas E.; Buckley-Geer, Elizabeth; Lin, Huan

We report on SPT-CLJ2011-5228, a giant system of arcs created by a cluster atmore » $z=1.06$. The arc system is notable for the presence of a bright central image. The source is a Lyman Break galaxy at $$z_s=2.39$$ and the mass enclosed within the 14 arc second radius Einstein ring is $$10^{14.2}$$ solar masses. We perform a full light profile reconstruction of the lensed images to precisely infer the parameters of the mass distribution. The brightness of the central image demands that the central total density profile of the lens be shallow. By fitting the dark matter as a generalized Navarro-Frenk-White profile---with a free parameter for the inner density slope---we find that the break radius is $$270^{+48}_{-76}$$ kpc, and that the inner density falls with radius to the power $$-0.38\\pm0.04$$ at 68 percent confidence. Such a shallow profile is in strong tension with our understanding of relaxed cold dark matter halos; dark matter only simulations predict the inner density should fall as $$r^{-1}$$. The tension can be alleviated if this cluster is in fact a merger; a two halo model can also reconstruct the data, with both clumps (density going as $$r^{-0.8}$$ and $$r^{-1.0}$$) much more consistent with predictions from dark matter only simulations. At the resolution of our Dark Energy Survey imaging, we are unable to choose between these two models, but we make predictions for forthcoming Hubble Space Telescope imaging that will decisively distinguish between them.« less

The activity of C-G at 3.5 AU from the Sun

NASA Astrophysics Data System (ADS)

Rubin, M.; Altwegg, K.

2014-04-01

Starting in early August the ROSINA instrument on board the Rosetta spacecraft (1] saw clearly cometary molecules above the spacecraft background. The COPS sensor, which measures the total density with its nude gauge, registered large density variations in line with the rotation period of the comet. Mapping this to the comet showed that especially the neck of the comet is very active whenever it comes into sunlight. However, the outgassing pattern is more complex. In this talk we give an overview on the measured density profiles along the Rosetta trajectory.

A Shuttle Upper Atmosphere Mass Spectrometer /SUMS/ experiment

NASA Technical Reports Server (NTRS)

Blanchard, R. C.; Duckett, R. J.; Hinson, E. W.

1982-01-01

A magnetic mass spectrometer is currently being adapted to the Space Shuttle Orbiter to provide repeated high altitude atmosphere data to support in situ rarefied flow aerodynamics research, i.e., in the high velocity, low density flight regime. The experiment, called Shuttle Upper Atmosphere Mass Spectrometer (SUMS), is the first attempt to design mass spectrometer equipment for flight vehicle aerodynamic data extraction. The SUMS experiment will provide total freestream atmospheric quantitites, principally total mass density, above altitudes at which conventional pressure measurements are valid. Experiment concepts, the expected flight profile, tradeoffs in the design of the total system and flight data reduction plans are discussed. Development plans are based upon a SUMS first flight after the Orbiter initial development flights.

A wide-field survey of satellite galaxies around the spiral galaxy M106

NASA Astrophysics Data System (ADS)

Kim, E.; Kim, M.; Hwang, N.; Lee, M. G.; Chun, M.-Y.; Ann, H. B.

2011-04-01

We present a wide-field survey of satellite galaxies in M106 (NGC 4258) covering a ?× 2° field around M106 using Canada-France-Hawaii Telescope/MegaCam. We find 16 satellite galaxy candidates of M106. Eight of these galaxies are found to be dwarf galaxies that are much smaller and fainter than the remaining galaxies. Three of these galaxies are new findings. Surface brightness profiles of 15 out of 16 satellite galaxies can be represented well by an exponential disc profile with varying scalelength. We derive the surface number density distribution of these satellite galaxies. The central number density profile (d < 100 kpc) is well fitted by a power law with a power index of -2.1 ± 0.5, similar to the expected power index of isothermal distribution. The luminosity function of these satellites is represented well by the Schechter function with a faint-end slope of -1.19+0.03-0.06. Integrated photometric properties (total luminosity, total colour and disc scalelength) and the spatial distribution of these satellite galaxies are found to be roughly similar to those of the Milky Way and M31.

Three Dimensional High-Resolution Reconstruction of the Ionosphere Over the Very Large Array

DTIC Science & Technology

2010-12-15

Watts Progress Report, Dec 10; 1 Final Report: Three Dimensional High-Resolution Reconstruction of the Ionosphere over the Very Large Array...proposed research is reconstruct the three-dimensional regional electron density profile of Earth’s ionosphere with spatial resolution of better than 10 km...10x better sensitivity to total electron content (TEC, or chord integrated density) in the ionosphere that does GPS. The proposal funds the

Fatty acid profile in patients with phenylketonuria and its relationship with bone mineral density.

PubMed

Lage, Sergio; Bueno, María; Andrade, Fernando; Prieto, José Angel; Delgado, Carmen; Legarda, María; Sanjurjo, Pablo; Aldámiz-Echevarría, Luis Jose

2010-12-01

Patients with phenylketonuria (PKU) undergo a restrictive vegan-like diet, with almost total absence of n-3 fatty acids, which have been proposed as potential contributors to bone formation in the healthy population. The PKU diet might lead these patients to bone mass loss and, consequently, to the development of osteopenia/osteoporosis. Therefore, we proposed to analyze their plasma fatty acid profile status and its relationship with bone health. We recruited 47 PKU patients for this cross-sectional study and divided the cohort into three age groups (6-10 years, 11-18 years, 19-42 years). We measured their plasma fatty acid profile and bone mineral density (BMD) (both at the femoral neck and the lumbar spine). Seventy-seven healthy controls also participated as reference values of plasma fatty acids. Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) and total n-3 fatty acids were significantly diminished in PKU patients compared with healthy controls. DHA, EPA, and total n-3 fatty acids were also positively associated with bone mineral density (r = 0.83, p = 0.010; r = 0.57, p = 0.006; r = 0.73, p = 0.040, respectively). There was no association between phenylalanine (Phe), Index of Dietary Control (IDC), calcium, 25-hydroxivitamin D concentrations, daily calcium intake, and BMD. Our results suggest a possible influence of essential fatty acids over BMD in PKU patients. The lack of essential n-3 fatty acids intake in the PKU diet might affect bone mineralization. Further clinical trials are needed to confirm the effect of the n-3 essential fatty acids on bone accrual in a cohort of PKU patients.

Ovarian Lipid Metabolism Modulates Circulating Lipids in Premenopausal Women.

PubMed

Jensen, Jeffrey T; Addis, Ilana B; Hennebold, Jon D; Bogan, Randy L

2017-09-01

The premenopausal circulating lipid profile may be linked to the hormonal profile and ovarian lipid metabolism. Assess how estradiol, progesterone, and ovarian lipid metabolism contributes to the premenopausal lipid profile; and evaluate the acute effects of a common hormonal oral contraceptive (OC) on circulating lipids. Experimental crossover with repeated measures. Academic hospitals. Eight healthy, regularly menstruating women. Participants underwent periodic serum sampling during a normal menstrual cycle; a standard 21-day, monophasic combined hormonal OC cycle (30 µg of ethinyl estradiol and 150 µg of levonorgestrel per day); menopause simulated by leuprolide acetate (22.5-mg depot); and an artificial menstrual cycle achieved via transdermal estradiol (50 to 300 µg/d) and vaginal micronized progesterone (100 to 300 mg/d). Primary outcomes included evaluation of total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein cholesterol, triglycerides, and the total cholesterol to HDL cholesterol ratio. To estimate the effect of estradiol, progesterone, and ovarian lipid metabolism, all specimens except those from the OC cycle were analyzed. Subgroup analysis was conducted on the follicular and luteal phases. In a separate analysis, the effect of the OC was evaluated relative to the normal menstrual cycle. Estradiol was significantly associated with increased levels of HDL cholesterol throughout the menstrual cycle and in the follicular phase. Ovarian effects were associated with reduced lipid levels, especially during the luteal phase. The OC was associated with an increased total cholesterol to HDL cholesterol ratio and triglycerides. Previously unappreciated factors including ovarian lipid metabolism may contribute to the premenopausal lipid profile. Copyright © 2017 by the Endocrine Society

Attenuated associations between increasing BMI and unfavorable lipid profiles in Chinese Buddhist vegetarians.

PubMed

Zhang, Hui-Jie; Han, Peng; Sun, Su-Yun; Wang, Li-Ying; Yan, Bing; Zhang, Jin-Hua; Zhang, Wei; Yang, Shu-Yu; Li, Xue-Jun

2013-01-01

Obesity is related to hyperlipidemia and risk of cardiovascular disease. Health benefits of vegetarian diets have well-documented in the Western countries where both obesity and hyperlipidemia were prevalent. We studied the association between BMI and various lipid/lipoprotein measures, as well as between BMI and predicted coronary heart disease probability in lean, low risk populations in Southern China. The study included 170 Buddhist monks (vegetarians) and 126 omnivore men. Interaction between BMI and vegetarian status was tested in the multivariable regression analysis adjusting for age, education, smoking, alcohol drinking, and physical activity. Compared with omnivores, vegetarians had significantly lower mean BMI, blood pressures, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, total cholesterol to high density lipoprotein ratio, triglycerides, apolipoprotein B and A-I, as well as lower predicted probability of coronary heart disease. Higher BMI was associated with unfavorable lipid/lipoprotein profile and predicted probability of coronary heart disease in both vegetarians and omnivores. However, the associations were significantly diminished in Buddhist vegetarians. Vegetarian diets not only lower BMI, but also attenuate the BMI-related increases of atherogenic lipid/ lipoprotein and the probability of coronary heart disease.

Effect of L-ascorbic acid on nickel-induced alterations in serum lipid profiles and liver histopathology in rats.

PubMed

Das, Kusal K; Gupta, Amrita Das; Dhundasi, Salim A; Patil, Ashok M; Das, Swastika N; Ambekar, Jeevan G

2006-01-01

Nickel exposure greatly depletes intracellular ascorbate and alters ascorbate-cholesterol metabolism. We studied the effect of the simultaneous oral treatment with L-ascorbic acid (50 mg/100 g body weight (BW) and nickel sulfate (2.0 mg/100 g BW, i.p) on nickelinduced changes in serum lipid profiles and liver histopathology. Nickel-treated rats showed a significant increase in serum low-density lipoprotein-cholesterol, total cholesterol, triglycerides, and a significant decrease in serum high-density lipoprotein-cholesterol. In the liver, nickel sulfate caused a loss of normal architecture, fatty changes, extensive vacuolization in hepatocytes, eccentric nuclei, and Kupffer cell hypertrophy. Simultaneous administration of L-ascorbic acid with nickel sulfate improved both the lipid profile and liver impairments when compared with rats receiving nickel sulfate only. The results indicate that L-ascorbic acid is beneficial in preventing nickel-induced lipid alterations and hepatocellular damage.

No Fat, No Sugar, No Salt . . . No Problem? Prevalence of "Low-Content" Nutrient Claims and Their Associations with the Nutritional Profile of Food and Beverage Purchases in the United States.

PubMed

Taillie, Lindsey Smith; Ng, Shu Wen; Xue, Ya; Busey, Emily; Harding, Matthew

2017-09-01

Nutrient claims are a commonly used marketing tactic, but the association between claims and nutritional quality of products is unknown. The objective of this study was to examine trends in the proportion of packaged food and beverage purchases with a nutrient claim, whether claims are associated with improved nutritional profile, and whether the proportion of purchases with claims differs by race/ethnicity or socioeconomic status. This cross-sectional study examined nutrient claims on more than 80 million food and beverage purchases from a transaction-level database of 40,000 US households from 2008 to 2012. χ 2 Tests were used to examine whether the proportion of purchases with a low/no-content claim changed over time or differed by race/ethnicity or household socioeconomic status. Pooled transactions were examined using t-tests to compare products' nutritional profiles overall and by food and beverage group. Thirteen percent of food and 35% of beverage purchases had a low-content claim. Prevalence of claims among purchases did not change over time. Low-fat claims were most prevalent for both foods and beverages (10% and 19%, respectively), followed by low-calorie (3% and 9%), low-sugar (2% and 8%), and low-sodium (2% for both) claims. Compared to purchases with no claim, purchases with any low-content claim had lower mean energy, total sugar, total fat, and sodium densities. However, the association between particular claim types and specific nutrient densities varied substantially, and purchases featuring a given low-content claim did not necessarily offer better overall nutritional profiles or better profiles for the claimed nutrient, relative to products without claims. In addition, there was substantial heterogeneity in associations between claims and nutrient densities within food and beverage groups. Variations in nutrient density by claim type and food and beverage group suggests that claims may have differential utility for certain foods or nutrients and, in some cases, may mislead about the overall nutritional quality of the food. Copyright © 2017 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.

Pressure profiles of plasmas confined in the field of a dipole magnet

NASA Astrophysics Data System (ADS)

Davis, Matthew Stiles

Understanding the maintenance and stability of plasma pressure confined by a strong magnetic field is a fundamental challenge in both laboratory and space plasma physics. Using magnetic and X-ray measurements on the Levitated Dipole Experiment (LDX), the equilibrium plasma pressure has been reconstructed, and variations of the plasma pressure for different plasma conditions have been examined. The relationship of these profiles to the magnetohydrodynamic (MHD) stability limit, and to the enhanced stability limit that results from a fraction of energetic trapped electrons, has been analyzed. In each case, the measured pressure profiles and the estimated fractional densities of energetic electrons were qualitatively consistent with expectations of plasma stability. LDX confines high temperature and high pressure plasma in the field of a superconducting dipole magnet. The strong dipole magnet can be either mechanically supported or magnetically levitated. When the dipole was mechanically supported, the plasma density profile was generally uniform while the plasma pressure was highly peaked. The uniform density was attributed to the thermal plasma being rapidly lost along the field to the mechanical supports. In contrast, the strongly peaked plasma pressure resulted from a fraction of energetic, mirror trapped electrons created by microwave heating at the electron cyclotron resonance (ECRH). These hot electrons are known to be gyrokinetically stabilized by the background plasma and can adopt pressure profiles steeper than the MHD limit. X-ray measurements indicated that this hot electron population could be described by an energy distribution in the range 50-100 keV. Combining information from the magnetic reconstruction of the pressure profile, multi-chord interferometer measurements of the electron density profile, and X-ray measurements of the hot electron energy distribution, the fraction of energetic electrons at the pressure peak was estimated to be ˜ 35% of the total electron population. When the dipole was magnetically levitated the plasma density increased substantially because particle losses to the mechanical supports were eliminated so particles could only be lost via slower cross-field transport processes. The pressure profile was observed to be broader during levitated operation than it was during supported operation, and the pressure appeared to be contained in both a thermal population and an energetic electron population. X-ray spectra indicated that the X-rays came from a similar hot electron population during levitated and supported operation; however, the hot electron fraction was an order of magnitude smaller during levitated operation (<3% of the total electron population). Pressure gradients for both supported and levitated plasmas were compared to the MHD limit. Levitated plasmas had pressure profiles that were (i) steeper than, (ii) shallower than, or (iii) near the MHD limit dependent on plasma conditions. However, those profiles that exceeded the MHD limit were observed to have larger fractions of energetic electrons. When the dipole magnet was supported, high pressure plasmas always had profiles that exceeded the MHD interchange stability limit, but the high pressure in these plasmas appeared to arise entirely from a population of energetic trapped electrons.

Differential therapeutic effects of nateglinide and acarbose on fasting and postprandial lipid profiles: a randomized trial.

PubMed

Zhou, Jian; Deng, Zixuan; Lu, Jingyi; Li, Hong; Zhang, Xiuzhen; Peng, Yongde; Mo, Yifei; Bao, Yuqian; Jia, Weiping

2015-04-01

Dyslipidemia is commonly seen in patients with type 2 diabetes mellitus (T2DM). The current study sought to compare the effects of nateglinide and acarbose, two antihyperglycemic agents, on both fasting and postprandial lipid profiles in Chinese subjects with T2DM. For this multicenter, open-label, randomized, active-controlled, parallel-group study, 103 antihyperglycemic agent-naive patients with T2DM were recruited from four hospitals in China. In total, 85 subjects (44 in the nateglinide group, 41 in the acarbose group) with a known complete lipid profile underwent the entire clinical trial and were included in the final analysis. Serum was collected in the fasting state and 30 and 120 min after a standardized meal (postprandial states) to measure the baseline lipid profiles; the same testing was performed upon completion of a 2-week course of nateglinide (120 mg three times a day) or acarbose (50 mg three times a day). Fasting triglyceride (TG) levels were significantly reduced by both nateglinide and acarbose (P<0.001), with acarbose providing a significantly more robust improvement (vs. nateglinide, P=0.005). Additionally, the TG levels at both postprandial times were significantly reduced by acarbose (P<0.001 at 30 min and P=0.002 at 120 min), whereas nateglinide treatment only significantly reduced the 30-min postprandial TG (P=0.029). Neither nateglinide nor acarbose treatment had significant impact on total cholesterol, high-density lipoprotein, low-density lipoprotein, or non-high-density lipoprotein cholesterol. Compared with nateglinide, acarbose has superior therapeutic efficacy for reducing fasting and postprandial TG levels in patients with T2DM.

Coconut oil predicts a beneficial lipid profile in pre-menopausal women in the Philippines

PubMed Central

Feranil, Alan B.; Duazo, Paulita L.; Kuzawa, Christopher W.; Adair, Linda S.

2011-01-01

Coconut oil is a common edible oil in many countries, and there is mixed evidence for its effects on lipid profiles and cardiovascular disease risk. Here we examine the association between coconut oil consumption and lipid profiles in a cohort of 1,839 Filipino women (age 35–69 years) participating in the Cebu Longitudinal Health and Nutrition Survey, a community based study in Metropolitan Cebu City. Coconut oil intake was measured as individual coconut oil intake calculated using two 24-hour dietary recalls (9.54 ± 8.92 grams). Cholesterol profiles were measured in plasma samples collected after an overnight fast. Mean lipid values in this sample were total cholesterol (TC) (186.52 ± 38.86 mg/dL), high density lipoprotein cholesterol (HDL-c) (40.85 ± 10.30 mg/dL), low density lipoprotein cholesterol (LDL-c) (119.42 ± 33.21 mg/dL), triglycerides (130.75 ± 85.29 mg/dL) and the TC/HDL ratio (4.80 ± 1.41). Linear regression models were used to estimate the association between coconut oil intake and each plasma lipid outcome after adjusting for total energy intake, age, body mass index (BMI), number of pregnancies, education, menopausal status, household assets and urban residency. Dietary coconut oil intake was positively associated with HDL-c levels. PMID:21669587

Pressure Balance at Mars and Solar Wind Interaction with the Martian Atmosphere

NASA Technical Reports Server (NTRS)

Krymskii, A. M.; Ness, N. F.; Crider, D. H.; Breus, T. K.; Acuna, M. H.; Hinson, D.

2003-01-01

The strongest crustal fields are located in certain regions in the Southern hemisphere. In the Northern hemisphere, the crustal fields are rather weak and usually do not prevent direct interaction between the SW and the Martian ionosphere/atmosphere. Exceptions occur in the isolated mini-magnetospheres formed by the crustal anomalies. Electron density profiles of the ionosphere of Mars derived from radio occultation data obtained by the Radio Science Mars Global Surveyor (MGS) experiment have been compared with the crustal magnetic fields measured by the MGS Magnetometer/Electron Reflectometer (MAG/ER) experiment. A study of 523 electron density profiles obtained at latitudes from +67 deg. to +77 deg. has been conducted. The effective scale-height of the electron density for two altitude ranges, 145-165 km and 165-185 km, and the effective scale-height of the neutral atmosphere density in the vicinity of the ionization peak have been derived for each of the profiles studied. For the regions outside of the potential mini-magnetospheres, the thermal pressure of the ionospheric plasma for the altitude range 145-185 km has been estimated. In the high latitude ionosphere at Mars, the total pressure at altitudes 160 and 180 km has been mapped. The solar wind interaction with the ionosphere of Mars and origin of the sharp drop of the electron density at the altitudes 200-210 km will be discussed.

Investigation of the Electron Density Variation During the 21 August 2017 Solar Eclipse

NASA Astrophysics Data System (ADS)

Reinisch, B. W.; Dandenault, P. B.; Galkin, I. A.; Hamel, R.; Richards, P. G.

2018-02-01

This paper presents a comparison of modeled and measured electron densities for the 21 August 2017 solar eclipse across the USA. The location of the instrument was (43.81°N, 247.32°E) where the maximum obscuration of 99.6% occurred at 17.53 hr UT on 21 August. The solar apparent time was 9.96 hr, and the duration of the eclipse was 2.7 hr. It was found that if it is assumed that there are no chromosphere emissions at totality, 30% coronal emission remaining at totality gave the best fit to the electron density variation at 150 km. The 30% coronal emission estimate has uncertainties associated with respect to uncertainties in the solar spectrum, the measured electron density, and the amount of chromosphere emissions remaining at totality. The agreement between the modeled and measured electron densities is excellent at 150 km with the assumed 30% coronal emission at totality. At other altitudes, the agreement is very good, but the altitude profile would be improved if the model peak electron density (NmF2) decayed more slowly to better match the data. The minimum NmF2 in the model occurs 10 min after totality when it decreases to 0.55 from its noneclipse value. The minimum of the NmF2 data occurs between 6 and 10 min after totality but is 15% larger. The total electron content decreases to 0.65 of its preeclipse value. These relative changes agree well with those predicted by others prior to the eclipse.

A study of the Ionospheric electron density profile with FORMOSAT-3/COSMIC observation data

NASA Astrophysics Data System (ADS)

Chou, Min-Yang; Tsai, Ho-Fang; Lin, Chi-Yen; Lee, I.-Te; Lin, Charles; Liu, Jann-Yenq

2015-04-01

The GPS Occultation Experiment payload onboard FORMOSAT-3/COSMIC microsatellite constellation is capable of scanning the ionospheric structure by the radio occultation (RO) technique to retrieve precise electron density profiles since 2006. Due to the success of FORMOSAT-3/COSMIC, the follow-on mission, FORMOSAT-7/COSMIC-2, is to launch 12 microsatellites in 2016 and 2018, respectively, with　the Global Navigation Satellite Systems (GNSS) RO instrument onboard for tracking GPS, Galileo and/or GLONASS satellite signals and to provide more than 8,000 RO soundings per day globally. An overview of the validation of the FORMOSAT-3/COSMIC ionospheric profiling is given by means of the traditional Abel transform through bending angle and total electron content (TEC), while the ionospheric data assimilation is also applied, based on the Gauss-Markov Kalman filter with the International Reference Ionosphere model (IRI-2007) and global ionosphere map (GIM) as background model, to assimilate TEC observations from FORMOSAT-3/COSMIC. The results shows comparison of electron density profiles from Abel inversion and data assimilation. Furthermore, an observing system simulation experiment is also applied to determine the impact of FORMOSAT-7/COSMIC-2 on ionospheric weather monitoring, which reveals an opportunity on advanced study of small spatial and temporal variations in the ionosphere.

Android and gynoid fat percentages and serum lipid levels in United States adults.

PubMed

Min, Kyoung-Bok; Min, Jin-Young

2015-03-01

Accumulating evidence suggests that fat distribution is a better predictor of cardiovascular disease than body mass index (BMI). The aim of this study was to investigate the association of android and gynoid fat percentages with lipid profiles to determine whether android and/or gynoid fat percentages are associated with serum lipid levels. A population-based cross-sectional study. Five thousand six hundred and ninety-six adults (20 years and older) who participated in the National Health and Nutrition Examination Survey 2003-2006. The regional body composition in the android and gynoid regions was defined by dual energy X-ray absorptiometry (DXA). The estimation of lipid risk profiles included total cholesterol, high-density lipoprotein (HDL) -cholesterol, low-density lipoprotein (LDL) -cholesterol and triglycerides (TG). Regardless of gender, android and gynoid body fat percentages were positively and significantly correlated with BMI and waist circumference. After adjustment for age, ethnicity, education, smoking, alcohol consumption, dyslipidaemia and BMI, increases in android fat percentage were significantly associated with total cholesterol, TG and HDL cholesterol in males, and total cholesterol, HDL cholesterol and LDL cholesterol in females. The gynoid fat percentages showed a positive correlation with total cholesterol in males, whereas gynoid fat accumulation in females showed a favourable association with TG and HDL cholesterol. The observed associations differed according to ethnic groups. Our results suggest that regional fat distribution in the android and gynoid regions have different effects on lipid profiles, and that fat in the android region, rather than the gynoid region, may be an important factor in determining the risk of cardiovascular disease. © 2014 John Wiley & Sons Ltd.

Anti-atherogenic effect of chromium picolinate in streptozotocin-induced experimental diabetes.

PubMed

Sundaram, Bhuvaneshwari; Singhal, Kirti; Sandhir, Rajat

2013-03-01

Several studies have implicated changes in the levels of trace elements in diabetes. Chromium is one such element that seems to potentiate insulin action, thereby regulating carbohydrate and lipid metabolism. The aim of the present study was to evaluate the effect of chromium supplementation as chromium picolinate on the lipid profile of streptozotocin (STZ)-induced diabetic rats. Rats were rendered diabetic by a single injection of STZ (50 mg/kg, i.p.). Chromium picolinate (1 mg/kg per day, p.o.) was administered to rats for a period of 4 weeks. At the end of the treatment period, plasma total lipids, triglycerides, total cholesterol and lipoprotein levels were determined, as was hepatic glucose-6-phosphate dehydrogenase activity. Total plasma lipids increased significantly in diabetic rats and this increase was ameliorated by chromium treatment for 4 weeks. Elevated total lipids in diabetic rats were due to increased plasma triglyceride and cholesterol levels. Chromium supplementation lowered plasma triglyceride and cholesterol levels to near normal. Chromium treatment also normalized low-density lipoprotein-cholesterol (LDL-C) and very low-density lipoprotein-cholesterol levels and improved the total cholesterol:high-density lipoprotein-cholesterol (HDL-C) and HDL-C:LDL-C ratios, suggesting an anti-atherogenic effect. In addition to improving the plasma lipid profile, chromium supplementation normalized liver glucose-6-phosphate dehydrogenase activity in diabetic rats. These results provide evidence that chromium picolinate effectively attenuates the dyslipidemia associated with diabetes and thus can be used as an adjuvant therapy in the treatment of diabetes and its associated complications. © 2012 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.

Lipoprotein profile, lipoprotein-associated phospholipase A2 and cardiovascular risk in hemodialysis patients.

PubMed

Rolla, Roberta; De Mauri, Andreana; Valsesia, Ambra; Vidali, Matteo; Chiarinotti, Doriana; Bellomo, Giorgio

2015-12-01

Cardiovascular disease is the leading cause of morbidity and mortality in hemodialysis patients; the increased risk of cardiovascular disease is due to accelerated atherosclerosis, inflammation and impaired lipoprotein metabolism. We aimed to evaluate lipoprotein-associated phospholipase A2 (Lp-PLA2) and some pro-inflammatory aspects of the lipoprotein profile in dialyzed patients in order to evaluate the relationship with the accelerated atherosclerosis and vascular accidents. In 102 dialysis patients and 40 non-uremic controls, we investigated the lipoprotein plasma profile, high sensitivity C-reactive protein (CRP), ceruloplasmin and serum amyloid A protein (SAA), and followed patients for 1 year to analyze the risk of acute cardiovascular events. Total cholesterol, low-density lipoprotein and high-density lipoprotein plasma levels were significantly lower in uremic patients than controls, whereas CRP, SAA, ceruloplasmin, Lp-PLA2 and their ratio with apolipoprotein A1 were significantly higher. Patients with Lp-PLA2 levels >194 nmol/min/ml had more acute cardiovascular events than patients with lower values. Our results show that in dialysis subjects: (1) low-density lipoproteins show a more atherogenic phenotype than in the general population; (2) high-density lipoproteins are less anti-inflammatory; (3) Lp-PLA2 could potentially be used to evaluate cardiovascular risk.

Short stature, abdominal obesity, insulin resistance and alterations in lipid profile in very low-income women living in Maceió, north-eastern Brazil.

PubMed

Florêncio, Telma T; Ferreira, Haroldo S; Cavalcante, Jairo C; Stux, Gabriela R; Sawaya, Ana L

2007-04-01

To test the hypothesis that short stature is associated with abdominal obesity, insulin resistance and lipid profile changes. Anthropometric data were collected from 237 women (18-60 years old), residents of a shantytown in Maceió. Biochemical profiles of 60 individuals drawn from this population were determined. Total and low-density lipoprotein (LDL) cholesterol levels and insulin resistance rose with increasing waist : hip circumference ratio, particularly in women. Short, overweight individuals exhibited larger biochemical alterations than overweight individuals of average stature. Short stature, when associated with overweight, is a risk factor for increased insulin resistance and alterations in lipid profile.

Using Ice and Dust Lines to Constrain the Surface Densities of Protoplanetary Disks

NASA Astrophysics Data System (ADS)

Powell, Diana; Murray-Clay, Ruth; Schlichting, Hilke E.

2017-05-01

We present a novel method for determining the surface density of protoplanetary disks through consideration of disk “dust lines,” which indicate the observed disk radial scale at different observational wavelengths. This method relies on the assumption that the processes of particle growth and drift control the radial scale of the disk at late stages of disk evolution such that the lifetime of the disk is equal to both the drift timescale and growth timescale of the maximum particle size at a given dust line. We provide an initial proof of concept of our model through an application to the disk TW Hya and are able to estimate the disk dust-to-gas ratio, CO abundance, and accretion rate in addition to the total disk surface density. We find that our derived surface density profile and dust-to-gas ratio are consistent with the lower limits found through measurements of HD gas. The CO ice line also depends on surface density through grain adsorption rates and drift and we find that our theoretical CO ice line estimates have clear observational analogues. We further apply our model to a large parameter space of theoretical disks and find three observational diagnostics that may be used to test its validity. First, we predict that the dust lines of disks other than TW Hya will be consistent with the normalized CO surface density profile shape for those disks. Second, surface density profiles that we derive from disk ice lines should match those derived from disk dust lines. Finally, we predict that disk dust and ice lines will scale oppositely, as a function of surface density, across a large sample of disks.

Affinity proteomic profiling of plasma for proteins associated to area-based mammographic breast density.

PubMed

Byström, Sanna; Eklund, Martin; Hong, Mun-Gwan; Fredolini, Claudia; Eriksson, Mikael; Czene, Kamila; Hall, Per; Schwenk, Jochen M; Gabrielson, Marike

2018-02-14

Mammographic breast density is one of the strongest risk factors for breast cancer, but molecular understanding of how breast density relates to cancer risk is less complete. Studies of proteins in blood plasma, possibly associated with mammographic density, are well-suited as these allow large-scale analyses and might shed light on the association between breast cancer and breast density. Plasma samples from 1329 women in the Swedish KARMA project, without prior history of breast cancer, were profiled with antibody suspension bead array (SBA) assays. Two sample sets comprising 729 and 600 women were screened by two different SBAs targeting a total number of 357 proteins. Protein targets were selected through searching the literature, for either being related to breast cancer or for being linked to the extracellular matrix. Association between proteins and absolute area-based breast density (AD) was assessed by quantile regression, adjusting for age and body mass index (BMI). Plasma profiling revealed linear association between 20 proteins and AD, concordant in the two sets of samples (p < 0.05). Plasma levels of seven proteins were positively associated and 13 proteins negatively associated with AD. For eleven of these proteins evidence for gene expression in breast tissue existed. Among these, ABCC11, TNFRSF10D, F11R and ERRF were positively associated with AD, and SHC1, CFLAR, ACOX2, ITGB6, RASSF1, FANCD2 and IRX5 were negatively associated with AD. Screening proteins in plasma indicates associations between breast density and processes of tissue homeostasis, DNA repair, cancer development and/or progression in breast cancer. Further validation and follow-up studies of the shortlisted protein candidates in independent cohorts will be needed to infer their role in breast density and its progression in premenopausal and postmenopausal women.

Estimating Volume, Biomass, and Carbon in Hedmark County, Norway Using a Profiling LiDAR

NASA Technical Reports Server (NTRS)

Nelson, Ross; Naesset, Erik; Gobakken, T.; Gregoire, T.; Stahl, G.

2009-01-01

A profiling airborne LiDAR is used to estimate the forest resources of Hedmark County, Norway, a 27390 square kilometer area in southeastern Norway on the Swedish border. One hundred five profiling flight lines totaling 9166 km were flown over the entire county; east-west. The lines, spaced 3 km apart north-south, duplicate the systematic pattern of the Norwegian Forest Inventory (NFI) ground plot arrangement, enabling the profiler to transit 1290 circular, 250 square meter fixed-area NFI ground plots while collecting the systematic LiDAR sample. Seven hundred sixty-three plots of the 1290 plots were overflown within 17.8 m of plot center. Laser measurements of canopy height and crown density are extracted along fixed-length, 17.8 m segments closest to the center of the ground plot and related to basal area, timber volume and above- and belowground dry biomass. Linear, nonstratified equations that estimate ground-measured total aboveground dry biomass report an R(sup 2) = 0.63, with an regression RMSE = 35.2 t/ha. Nonstratified model results for the other biomass components, volume, and basal area are similar, with R(sup 2) values for all models ranging from 0.58 (belowground biomass, RMSE = 8.6 t/ha) to 0.63. Consistently, the most useful single profiling LiDAR variable is quadratic mean canopy height, h (sup bar)(sub qa). Two-variable models typically include h (sup bar)(sub qa) or mean canopy height, h(sup bar)(sub a), with a canopy density or a canopy height standard deviation measure. Stratification by productivity class did not improve the nonstratified models, nor did stratification by pine/spruce/hardwood. County-wide profiling LiDAR estimates are reported, by land cover type, and compared to NFI estimates.

The determination of ionospheric electron content and distribution from satellite observations. Part 2. Results of the analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garriott, O K

1960-04-01

The results of observations of the radio transmissions from Sputnik III (1958 δ 2) in an 8-month period are presented. The measurements of integrated electron density are made in two ways, described in part 1. The measurements reveal the diurnal variation of the total ionospheric electron content; and the ratio of the total content to the content of the lower ionosphere below the height of maximum density in the F layer is obtained. An estimate of the average electron-density profile above the F-layer peak is made possible by the slow variation in the height of the satellite due to rotationmore » of the perigee position. The gross effects of large magnetic storms on the electron content and distribution are found.« less

Sex differences in lipid profiles and treatment utilization among young adults with acute myocardial infarction: Results from the VIRGO study.

PubMed

Lu, Yuan; Zhou, Shengfan; Dreyer, Rachel P; Caulfield, Michael; Spatz, Erica S; Geda, Mary; Lorenze, Nancy P; Herbert, Peter; D'Onofrio, Gail; Jackson, Elizabeth A; Lichtman, Judith H; Bueno, Héctor; Spertus, John A; Krumholz, Harlan M

2017-01-01

Young women with acute myocardial infarction (AMI) have higher mortality risk than similarly aged men. An adverse lipid profile is an important risk factor for cardiovascular outcomes after AMI, but little is known about whether young women with AMI have a higher-risk lipid pattern than men. We characterized sex differences in lipid profiles and treatment utilization among young adults with AMI. A total of 2,219 adults with AMI (1,494 women) aged 18-55 years were enrolled from 103 hospitals in the United States (2008-2012). Serum lipids and lipoprotein subclasses were measured 1 month after discharge. More than 90% of adults were discharged on a statin, but less than half received a high-intensity dose and 12% stopped taking treatments by 1 month. For both men and women, the median of low-density lipoprotein (LDL) cholesterol was reduced to <100 mg/dL 1 month after discharge for AMI, but high-density lipoprotein (HDL) cholesterol remained <40 mg/dL. Multivariate regression analyses showed that young women had favorable lipoprotein profiles compared with men: women had higher HDL cholesterol and HDL large particle, but lower total cholesterol-to-HDL cholesterol ratio and LDL small particle. Young women with AMI had slightly favorable lipid and lipoprotein profiles compared with men, suggesting that difference in lipid and lipoprotein may not be a major contributor to sex differences in outcomes after AMI. In both men and women, statin remained inadequately used, and low HDL cholesterol level was a major lipid abnormality. Copyright © 2016 Elsevier Inc. All rights reserved.

Alteration of lipid profile in subclinical hypothyroidism: a meta-analysis.

PubMed

Liu, Xiao-Li; He, Shan; Zhang, Shao-Fang; Wang, Jun; Sun, Xiu-Fa; Gong, Chun-Mei; Zheng, Shi-Jie; Zhou, Ji-Chang; Xu, Jian

2014-08-14

Previous studies yielded controversial results about the alteration of lipid profiles in patients with subclinical hypothyroidism. We performed a meta-analysis to investigate the association between subclinical hypothyroidism and lipid profiles. We searched PubMed, Cochrane Library, and China National Knowledge Infrastructure articles published January 1990 through January 2014. Dissertation databases (PQDT and CDMD) were searched for additional unpublished articles. We included articles reporting the relationship between subclinical hypothyroidism and at least 1 parameter of lipid profiles, and calculated the overall weighted mean difference (WMD) with a random effects model. Meta-regression was used to explore the source of heterogeneity among studies, and the Egger test, Begg test, and the trim and fill method were used to assess potential publication bias. Sixteen observational studies were included in our analysis. Meta-analysis suggested that the serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and total triglyceride levels were significantly increased in patients with subclinical hypothyroidism compared with euthyroidism individuals; the WMD were 12.17 mg/dl, 7.01 mg/dl, and 13.19 mg/dl, respectively (P<0.001 for all). No significant difference was observed for serum high-density lipoprotein cholesterol (HDL-C). Match strategy was the main source of heterogeneity among studies in TC and LDL-C analysis. Potential publication bias was found in TC and LDL-C analysis by the Egger test or Begg test and was not confirmed by the trim and fill method. Subclinical hypothyroidism may correlate with altered lipid profile. Previous studies had limitations in the control of potential confounding factors and further studies should consider those factors.

Impact of a 12-week high-intensity interval training without caloric restriction on body composition and lipid profile in sedentary healthy overweight/obese youth

PubMed Central

Khammassi, Marwa; Ouerghi, Nejmeddine; Hadj-Taieb, Sameh; Feki, Moncef; Thivel, David; Bouassida, Anissa

2018-01-01

Although High-intensity interval training (HIIT) has shown its effectiveness in improving body composition, cardio-respiratory fitness and lipid profile in obese adults, evidences remain limited in overweight/obese youth. This study was conducted to investigate the effect of a 12-week HIIT program without caloric restriction on body composition and lipid profile among young overweight/obese men. Twenty healthy obese youth were randomly allocated into two groups; experimental group (HIIT) and control group. The HIIT program consisted in 3 exercises sessions per week (30 sec of work at 100% maximal aerobic velocity [MAV]) interspersed by 30 sec of active recovery at 50% MAV, starting by 15 repetitions to reach 27 by the end of the program. Aerobic capacity (MAV and maximum oxygen uptake [VO2max]), body composition (body mass index [BMI], waist circumference [WC], and fat mass percent) and lipid profile (triglycerides [TG] and total, high-density lipoprotein [HDL] and low-density lipoprotein [LDL] cholesterol) were determined before and after the HIIT program. Following 12 weeks of HIIT, WC, BMI (P<0.01), and fat mass percent (P<0.05) were significantly decreased. MAV and VO2max were significantly improved in the HIIT group, only. Total cholesterol (P<0.05) and TG (P<0.05) decreased significantly in the HIIT group, while LDL and HDL cholesterol levels remained unchanged in both groups. HIIT may be particularly useful in overweight/obese youth to improve body composition, aerobic fitness and lipid profile. PMID:29511662

Impact of a 12-week high-intensity interval training without caloric restriction on body composition and lipid profile in sedentary healthy overweight/obese youth.

PubMed

Khammassi, Marwa; Ouerghi, Nejmeddine; Hadj-Taieb, Sameh; Feki, Moncef; Thivel, David; Bouassida, Anissa

2018-02-01

Although High-intensity interval training (HIIT) has shown its effectiveness in improving body composition, cardio-respiratory fitness and lipid profile in obese adults, evidences remain limited in overweight/obese youth. This study was conducted to investigate the effect of a 12-week HIIT program without caloric restriction on body composition and lipid profile among young overweight/obese men. Twenty healthy obese youth were randomly allocated into two groups; experimental group (HIIT) and control group. The HIIT program consisted in 3 exercises sessions per week (30 sec of work at 100% maximal aerobic velocity [MAV]) interspersed by 30 sec of active recovery at 50% MAV, starting by 15 repetitions to reach 27 by the end of the program. Aerobic capacity (MAV and maximum oxygen uptake [VO2max]), body composition (body mass index [BMI], waist circumference [WC], and fat mass percent) and lipid profile (triglycerides [TG] and total, high-density lipoprotein [HDL] and low-density lipoprotein [LDL] cholesterol) were determined before and after the HIIT program. Following 12 weeks of HIIT, WC, BMI ( P <0.01), and fat mass percent ( P <0.05) were significantly decreased. MAV and VO2max were significantly improved in the HIIT group, only. Total cholesterol ( P <0.05) and TG ( P <0.05) decreased significantly in the HIIT group, while LDL and HDL cholesterol levels remained unchanged in both groups. HIIT may be particularly useful in overweight/obese youth to improve body composition, aerobic fitness and lipid profile.

Chronic hepatitis C infection is associated with insulin resistance and lipid profiles.

PubMed

Dai, Chia-Yen; Yeh, Ming-Lun; Huang, Chung-Feng; Hou, Chen-Hsiu; Hsieh, Ming-Yen; Huang, Jee-Fu; Lin, I-Ling; Lin, Zu-Yau; Chen, Shinn-Chern; Wang, Liang-Yen; Chuang, Wan-Long; Yu, Ming-Lung; Tung, Hung-Da

2015-05-01

Chronic hepatitis C virus (HCV) infection has been suggested to be associated with non-insulin-dependent diabetes mellitus and lipid profiles. This study aimed to investigate the possible relationships of insulin resistance (IR) and lipid profiles with chronic hepatitis C (CHC) patients in Taiwan. We enrolled 160 hospital-based CHC patients with liver biopsy and the 480 controlled individuals without CHC and chronic hepatitis B from communities without known history of non-insulin-dependent diabetes mellitus. Fasting plasma glucose, total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TGs), alanine aminotransferase, and serum insulin levels, and homeostasis model assessment (HOMA-IR) were tested. When comparing factors between CHC patients, and sex- and age-matched controls who had no HCV infection, patients with HCV infection had a significantly higher alanine aminotransferase level, fasting plasma glucose level, insulin level, and HOMA-IR (P < 0.001, P = 0.023, P = 0.017, and P = 0.011, respectively), and significantly lower TG level (P = 0.023), total cholesterol, and HDL-C and LDL-C levels (all P < 0.001) than 480 controls. In multivariate logistic regression analyses, a low total cholesterol, a low TGs, and a high HOMA-IR are independent factors significantly associated with chronic HCV infection. In the 160 CHC patients (41 patients with high HOMA-IR [> 2.5]), a high body mass index, TGs, and HCV RNA level are independent factors significantly associated with high HOMA-IR in multivariate logistic analyses. Chronic HCV infection was associated with metabolic characteristics including IR and lipid profile. IR was also associated with virological characteristics. © 2013 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.

Body Mass Index Is Better than Other Anthropometric Indices for Identifying Dyslipidemia in Chinese Children with Obesity

PubMed Central

Jing, Jin; Ma, Jun; Chen, Yajun; Li, Xiuhong; Yang, Wenhan; Guo, Li; Jin, Yu

2016-01-01

Background Body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) are used in screening and predicting obesity in adults. However, the best identifier of metabolic complications in children with obesity remains unclear. This study evaluated lipid profile distribution and investigated the best anthropometric parameter in association with lipid disorders in children with obesity. Methods A total of 2243 school children aged 7–17 years were enrolled in Guangzhou, China, in 2014. The anthropometric indices and lipid profiles were measured. Dyslipidemia was defined according to the US Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents. The association between anthropometry (BMI, WC, and WHR) and lipid profile values was examined using chi-square analysis and discriminant function analysis. Information about demography, physical activity, and dietary intake was provided by the participant children and their parents. Results Children aged 10–14 and 15–17 years old generally had higher triglyceride values but lower median concentration of total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol compared with children aged 7–9 years old (all P < 0.001). These lipid parameters fluctuated in children aged 10–14 years old. The combination of age groups, BMI, WC and WHR achieved 65.1% accuracy in determining dyslipidemic disorders. BMI correctly identified 77% of the total dyslipidemic disorders in obese children, which was higher than that by WHR (70.8%) (P< 0.05). Conclusion The distribution of lipid profiles in Chinese children differed between younger and older age groups, and the tendency of these lipid levels remarkably fluctuated during 10 to 14 years old. BMI had better practical utility in identifying dyslipidemia among school-aged children with obesity compared with other anthropometric measures. PMID:26963377

Body Mass Index Is Better than Other Anthropometric Indices for Identifying Dyslipidemia in Chinese Children with Obesity.

PubMed

Zhu, Yanna; Shao, Zixian; Jing, Jin; Ma, Jun; Chen, Yajun; Li, Xiuhong; Yang, Wenhan; Guo, Li; Jin, Yu

2016-01-01

Body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) are used in screening and predicting obesity in adults. However, the best identifier of metabolic complications in children with obesity remains unclear. This study evaluated lipid profile distribution and investigated the best anthropometric parameter in association with lipid disorders in children with obesity. A total of 2243 school children aged 7-17 years were enrolled in Guangzhou, China, in 2014. The anthropometric indices and lipid profiles were measured. Dyslipidemia was defined according to the US Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents. The association between anthropometry (BMI, WC, and WHR) and lipid profile values was examined using chi-square analysis and discriminant function analysis. Information about demography, physical activity, and dietary intake was provided by the participant children and their parents. Children aged 10-14 and 15-17 years old generally had higher triglyceride values but lower median concentration of total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol compared with children aged 7-9 years old (all P < 0.001). These lipid parameters fluctuated in children aged 10-14 years old. The combination of age groups, BMI, WC and WHR achieved 65.1% accuracy in determining dyslipidemic disorders. BMI correctly identified 77% of the total dyslipidemic disorders in obese children, which was higher than that by WHR (70.8%) (P< 0.05). The distribution of lipid profiles in Chinese children differed between younger and older age groups, and the tendency of these lipid levels remarkably fluctuated during 10 to 14 years old. BMI had better practical utility in identifying dyslipidemia among school-aged children with obesity compared with other anthropometric measures.

Proatherogenic Lipid Profile in Early Childhood: Association with Weight Status at 4 Years and Parental Obesity.

PubMed

Riaño-Galán, Isolina; Fernández-Somoano, Ana; Rodríguez-Dehli, Cristina; Valvi, Damaskini; Vrijheid, Martine; Tardón, Adonina

2017-08-01

To determine lipid profiles in early childhood and evaluate their association with weight status at 4 years of age. Additionally, we evaluated whether the risk of overweight or having an altered lipid profile was associated with parental weight status. Five hundred eighty two mothers and their 4-year-old children from 2 Spanish population-based cohorts were studied. Weight status in children at 4 years of age was classified as overweight or obese using the International Obesity Task Force criteria. Plasma total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were determined in children and lipid ratios were calculated. A proatherogenic lipid profile was defined as having the 3 lipid ratios in the third tertile. A total of 12.9% of children were overweight and 6.4% were obese. Weight status at 4 years of age was related to maternal prepregnancy body mass index, paternal body mass index, gestational diabetes, and birth weight, but not with other sociodemographic characteristics of the mother. We found no association with gestational age, sex of the child, or breastfeeding. The risk of overweight/obesity was increased 4.17-fold if mothers were overweight/obese (95% CI 1.76-9.88) and 5.1-fold (95% CI 2.50-10.40) if both parents were overweight/obese. There were 133 children (22.8%) with a proatherogenic lipid profile. The risk of a proatherogenic lipid profile was increased 2.44-fold (95% CI 1.54-3.86) if they were overweight/obese at 4 years of age and 2-fold if the father was overweight/obese (95% CI 1.22-3.35). Four-year-old overweight/obese children have higher lipid risk profiles. Offspring of overweight/obese parents have an increased risk for obesity and a proatherogenic lipid profile. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

Association of height and pubertal timing with lipoprotein subclass profile: exploring the role of genetic and environmental effects.

PubMed

Jelenkovic, Aline; Bogl, Leonie H; Rose, Richard J; Kangas, Antti J; Soininen, Pasi; Ala-Korpela, Mika; Kaprio, Jaakko; Silventoinen, Karri

2013-01-01

Little is known about the relationship between growth and lipoprotein profile. We aimed to analyze common genetic and environmental factors in the association of height from late childhood to adulthood and pubertal timing with serum lipid and lipoprotein subclass profile. A longitudinal cohort of Finnish twin pairs (FinnTwin12) was analyzed using self-reported height at 11-12, 14, 17 years and measured stature at adult age (21-24 years). Data were available for 719 individual twins including 298 complete pairs. Serum lipids and lipoprotein subclasses were measured by proton nuclear magnetic resonance spectroscopy. Multivariate variance component models for twin data were fitted. Cholesky decomposition was used to partition the phenotypic covariation among traits into additive genetic and unique environmental correlations. In men, the strongest associations for both adult height and puberty were observed with total cholesterol, low-density lipoprotein cholesterol, intermediate-density lipoprotein cholesterol, and low-density lipoprotein particle subclasses (max. r = -0.19). In women, the magnitude of the correlations was weaker (max. r = -0.13). Few associations were detected between height during adolescence and adult lipid profile. Early onset of puberty was related to an adverse lipid profile, but delayed pubertal development in girls was associated with an unfavorable profile, as well. All associations were mediated mainly by additive genetic factors, but unique environmental effects cannot be disregarded. Early puberty and shorter adult height relate to higher concentrations of atherogenic lipids and lipoprotein particles in early adulthood. Common genetic effects behind these phenotypes substantially contribute to the observed associations. Copyright © 2013 Wiley Periodicals, Inc.

Core or Cusps: The Central Dark Matter Profile of a Strong Lensing Cluster with a Bright Central Image at Redshift 1

NASA Astrophysics Data System (ADS)

Collett, Thomas E.; Buckley-Geer, Elizabeth; Lin, Huan; Bacon, David; Nichol, Robert C.; Nord, Brian; Morice-Atkinson, Xan; Amara, Adam; Birrer, Simon; Kuropatkin, Nikolay; More, Anupreeta; Papovich, Casey; Romer, Kathy K.; Tessore, Nicolas; Abbott, Tim M. C.; Allam, Sahar; Annis, James; Benoit-Lévy, Aurlien; Brooks, David; Burke, David L.; Carrasco Kind, Matias; Castander, Francisco Javier J.; D'Andrea, Chris B.; da Costa, Luiz N.; Desai, Shantanu; Diehl, H. Thomas; Doel, Peter; Eifler, Tim F.; Flaugher, Brenna; Frieman, Josh; Gerdes, David W.; Goldstein, Daniel A.; Gruen, Daniel; Gschwend, Julia; Gutierrez, Gaston; James, David J.; Kuehn, Kyler; Kuhlmann, Steve; Lahav, Ofer; Li, Ting S.; Lima, Marcos; Maia, Marcio A. G.; March, Marisa; Marshall, Jennifer L.; Martini, Paul; Melchior, Peter; Miquel, Ramon; Plazas, Andrs A.; Rykoff, Eli S.; Sanchez, Eusebio; Scarpine, Vic; Schindler, Rafe; Schubnell, Michael; Sevilla-Noarbe, Ignacio; Smith, Mathew; Sobreira, Flavia; Suchyta, Eric; Swanson, Molly E. C.; Tarle, Gregory; Tucker, Douglas L.; Walker, Alistair R.

2017-07-01

We report on SPT-CLJ2011-5228, a giant system of arcs created by a cluster at z = 1.06. The arc system is notable for the presence of a bright central image. The source is a Lyman break galaxy at z s = 2.39 and the mass enclosed within the Einstein ring of radius 14 arcsec is ˜ {10}14.2 {M}⊙ . We perform a full reconstruction of the light profile of the lensed images to precisely infer the parameters of the mass distribution. The brightness of the central image demands that the central total density profile of the lens be shallow. By fitting the dark matter as a generalized Navarro-Frenk-White profile—with a free parameter for the inner density slope—we find that the break radius is {270}-76+48 kpc, and that the inner density falls with radius to the power -0.38 ± 0.04 at 68% confidence. Such a shallow profile is in strong tension with our understanding of relaxed cold dark matter halos; dark matter-only simulations predict that the inner density should fall as {r}-1. The tension can be alleviated if this cluster is in fact a merger; a two-halo model can also reconstruct the data, with both clumps (density varying as {r}-0.8 and {r}-1.0) much more consistent with predictions from dark matter-only simulations. At the resolution of our Dark Energy Survey imaging, we are unable to choose between these two models, but we make predictions for forthcoming Hubble Space Telescope imaging that will decisively distinguish between them.

Sedentary lifestyle and its relation to cardiovascular risk factors, insulin resistance and inflammatory profile.

PubMed

León-Latre, Montserrat; Moreno-Franco, Belén; Andrés-Esteban, Eva M; Ledesma, Marta; Laclaustra, Martín; Alcalde, Víctor; Peñalvo, José L; Ordovás, José M; Casasnovas, José A

2014-06-01

To analyze the association between sitting time and biomarkers of insulin resistance and inflammation in a sample of healthy male workers. Cross-sectional study carried out in a sample of 929 volunteers belonging to the Aragon Workers' Health Study cohort. Sociodemographic, anthropometric, pharmacological and laboratory data were collected: lipids-total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, apolipoproteins A-1 and B-100, lipoprotein (a)-, insulin resistance-glucose, glycated hemoglobin, homeostasis model assessment of insulin resistance, insulin, and triglyceride/high-density lipoprotein cholesterol ratio-, and inflammatory profile-C-reactive protein and leukocytes. Information on sitting time and physical activity was assessed using a questionnaire. Sedentary behavior was analyzed in terms of prevalences and medians, according to tertiles, using a multivariate model (crude and adjusted linear regression) with biomarkers of inflammation and insulin resistance. The most sedentary individuals had higher body mass index, greater waist circumference, and higher systolic blood pressure, with a significant upward trend in each tertile. Likewise, they had a worse lipid profile with a higher C-reactive protein level, homeostasis model assessment of insulin resistance index, triglyceride/high-density lipoprotein cholesterol ratio, and insulin concentration. In the multivariate analysis, we observed a significant association between the latter parameters and sitting time in hours (log C-reactive protein [β = 0.07], log homeostasis model assessment of insulin resistance index [β = 0.05], triglyceride/high-density lipoprotein cholesterol ratio [β = 0.23], and insulin [β = 0.44]), which remained after adjustment for metabolic equivalents-h/week. Workers who spend more time sitting show a worse inflammatory and insulin resistance profile independently of the physical activity performed. Copyright © 2013 Sociedad Española de Cardiología. Published by Elsevier Espana. All rights reserved.

Dietary Sulfur-Containing Amino Acids Are Associated with Higher Prevalence of Overweight/Obesity in Northern Chinese Adults, an Internet-Based Cross-Sectional Study.

PubMed

Li, Yan-Chuan; Li, Yu-Zheng; Li, Rui; Lan, Li; Li, Chun-Long; Huang, Min; Shi, Dan; Feng, Ren-Nan; Sun, Chang-Hao

2018-06-07

Elevation of plasma sulfur-containing amino acids (SAAs) is generally associated with higher body mass index (BMI) and unfavorable lipid profiles. It is not known how dietary SAAs relate to these associations in humans. A convenient tool named internet-based dietary questionnaire for Chinese (IDQC) was used to estimate dietary SAAs intake. A total of 936 participants were randomly recruited and asked to complete the IDQC. Furthermore, 90 subjects were randomly selected to perform a subgroup study. The associations between dietary SAAs and prevalence of obesity, lipid profiles, and status of insulin resistance (IR), inflammation and oxidative stress were assessed. Dietary total SAAs and cysteine of overweight/obese participants were significantly higher. Dietary total SAAs and cysteine were positively associated with BMI and waist circumference. Higher dietary total SAAs were associated with higher prevalence of overweight/obesity. Higher dietary total SAAs and cysteine also associated with higher serum triglyceride (total cholesterol), low density lipoprotein, fasting blood glucose, 2 h-postprandial glucose, and homeostasis model assessment of IR. In the subgroup study, positive associations between dietary SAAs and inflammation biomarkers were also observed. Dietary SAAs are associated with higher prevalence of overweight/obesity, unfavorable lipid profiles and status of IR, and inflammation. © 2018 S. Karger AG, Basel.

A new method to quantify the effects of baryons on the matter power spectrum

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schneider, Aurel; Teyssier, Romain, E-mail: aurel@physik.uzh.ch, E-mail: teyssier@physik.uzh.ch

2015-12-01

Future large-scale galaxy surveys have the potential to become leading probes for cosmology provided the influence of baryons on the total mass distribution is understood well enough. As hydrodynamical simulations strongly depend on details in the feedback implementations, no unique and robust predictions for baryonic effects currently exist. In this paper we propose a baryonic correction model that modifies the density field of dark-matter-only N-body simulations to mimic the effects of baryons from any underlying adopted feedback recipe. The model assumes haloes to consist of 4 components: 1- hot gas in hydrostatical equilibrium, 2- ejected gas from feedback processes, 3-more » central galaxy stars, and 4- adiabatically relaxed dark matter, which all modify the initial dark-matter-only density profiles. These altered profiles allow to define a displacement field for particles in N-body simulations and to modify the total density field accordingly. The main advantage of the baryonic correction model is to connect the total matter density field to the observable distribution of gas and stars in haloes, making it possible to parametrise baryonic effects on the matter power spectrum. We show that the most crucial quantities are the mass fraction of ejected gas and its corresponding ejection radius. The former controls how strongly baryons suppress the power spectrum, while the latter provides a measure of the scale where baryonic effects become important. A comparison with X-ray and Sunyaev-Zel'dovich cluster observations suggests that baryons suppress wave modes above k∼0.5 h/Mpc with a maximum suppression of 10-25 percent around k∼ 2 h/Mpc. More detailed observations of the gas in the outskirts of groups and clusters are required to decrease the large uncertainties of these numbers.« less

Cholesterol concentrations in lipoprotein fractions separated by anion-exchange-high-performance liquid chromatography in healthy dogs and dogs with hypercholesterolemia.

PubMed

Oda, Hitomi; Mori, Akihiro; Hirowatari, Yuji; Takoura, Toshie; Manita, Daisuke; Takahashi, Tomoya; Shono, Saori; Onozawa, Eri; Mizutani, Hisashi; Miki, Yohei; Itabashi, Yukiko; Sako, Toshinori

2017-10-01

Anion-exchange (AEX)-high-performance liquid chromatography (HPLC) for measurement of cholesterol can be used to separate serum lipoproteins (high-density lipoprotein (HDL); low-density lipoprotein (LDL); intermediate-density lipoprotein (IDL); very-low-density lipoprotein (VLDL)) in humans. However, AEX-HPLC has not been applied in veterinary practice. We had three objectives: (i) the validation of AEX-HPLC methods including the correlation of serum cholesterol concentration in lipoprotein fraction measured by AEX-HPLC and gel permeation-HPLC (GP-HPLC) in healthy dogs and those with hypercholesterolemia was investigated; (ii) the reference intervals of lipoprotein fractions measured by AEX-HPLC from healthy dogs (n=40) was established; (iii) lipoprotein fractions from the serum of healthy dogs (n=12) and dogs with hypercholesterolemia (n=23) were compared. Analytic reproducibility and precision of AEX-HPLC were acceptable. Positive correlation between serum concentrations of total cholesterol (Total-Chol), HDL cholesterol (HDL-Chol), LDL cholesterol (LDL-Chol)+IDL cholesterol (IDL-Chol), and VLDL cholesterol (VLDL-Chol) was noted for AEX-HPLC and GP-HPLC in healthy dogs and dogs with hypercholesterolemia. Reference intervals measured by AEX-HPLC for serum concentrations of Total-Chol, HDL-Chol, and LDL-Chol were determined to be 2.97-9.32, 2.79-6.57, 0.16-3.28mmol/L (2.5-97.5% interval), respectively. Furthermore, there was significant difference in lipoprotein profiles between healthy and dogs with hypercholesterolemia. These results suggest that AEX-HPLC can be used to evaluate lipoprotein profiles in dogs and could be a new useful indicator of hyperlipidemia in dogs. Copyright © 2017 Elsevier Ltd. All rights reserved.

Does a lack of physical activity explain the rheumatoid arthritis lipid profile?

PubMed

AbouAssi, Hiba; Connelly, Margery A; Bateman, Lori A; Tune, K Noelle; Huebner, Janet L; Kraus, Virginia B; Winegar, Deborah A; Otvos, James D; Kraus, William E; Huffman, Kim M

2017-02-10

In rheumatoid arthritis (RA), cardiovascular risk is associated with paradoxical reductions in total cholesterol, low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein-cholesterol (HDL-C). Concentrations of small LDL (LDL-P) and HDL (HDL-P) particles are also reduced with increased inflammation and disease activity in RA patients. Here we sought to identify which measure(s) of inflammation, disease activity and cardiometabolic risk contribute most to the RA-associated lipoprotein profile. NMR lipoprotein measurements were obtained for individuals with RA (n = 50) and age-, gender-, and body mass index (BMI)-matched controls (n = 39). Groups were compared using 39 matched pairs with 11 additional subjects used in RA only analyses. Among RA patients, relationships were determined for lipoprotein parameters with measures of disease activity, disability, pain, inflammation, body composition, insulin sensitivity and exercise. Percentage of time spent in basal activity (<1 metabolic equivalent) and exercise (≥3 metabolic equivalents) were objectively-determined. Subjects with RA had fewer total and small LDL-P as well as larger LDL and HDL size (P < 0.05). Among RA patients, pain and disability were associated with fewer small HDL-P (P < 0.05), while interleukin (IL)-6, IL-18, and TNF-α were associated with LDL size (P < 0.05). BMI, waist circumference, abdominal visceral adiposity and insulin resistance were associated with more total and small LDL-P, fewer large HDL-P, and a reduction in HDL size (P < 0.05). Most similar to the RA lipoprotein profile, more basal activity (minimal physical activity) and less exercise time were associated with fewer small LDL-P and total and small HDL-P (P < 0.05). The RA-associated lipoprotein profile is associated with a lack of physical activity. As this was a cross-sectional investigation and not an intervention and was performed from 2008-13, this study was not registered in clinicaltrials.gov.

First-Principles-Driven Model-Based Optimal Control of the Current Profile in NSTX-U

NASA Astrophysics Data System (ADS)

Ilhan, Zeki; Barton, Justin; Wehner, William; Schuster, Eugenio; Gates, David; Gerhardt, Stefan; Kolemen, Egemen; Menard, Jonathan

2014-10-01

Regulation in time of the toroidal current profile is one of the main challenges toward the realization of the next-step operational goals for NSTX-U. A nonlinear, control-oriented, physics-based model describing the temporal evolution of the current profile is obtained by combining the magnetic diffusion equation with empirical correlations obtained at NSTX-U for the electron density, electron temperature, and non-inductive current drives. In this work, the proposed model is embedded into the control design process to synthesize a time-variant, linear-quadratic-integral, optimal controller capable of regulating the safety factor profile around a desired target profile while rejecting disturbances. Neutral beam injectors and the total plasma current are used as actuators to shape the current profile. The effectiveness of the proposed controller in regulating the safety factor profile in NSTX-U is demonstrated via closed-loop predictive simulations carried out in PTRANSP. Supported by PPPL.

The role of high-density lipoprotein cholesterol in risk for posttraumatic stress disorder: taking a nutritional approach toward universal prevention.

PubMed

Hamazaki, K; Nishi, D; Yonemoto, N; Noguchi, H; Kim, Y; Matsuoka, Y

2014-09-01

Several cross-sectional studies, but no prospective studies, have reported an association between an abnormal lipid profile and posttraumatic stress disorder (PTSD). We hypothesized that an abnormal lipid profile might predict risk for developing PTSD. In this prospective study, we analyzed data from 237 antidepressant-naïve severely injured patients who participated in the Tachikawa Cohort of Motor Vehicle Accident Study. High-density lipoprotein cholesterol (HDL-C) levels at baseline were significantly lower in patients with PTSD than those without PTSD at 6 months after motor vehicle accident (MVA) and were inversely associated with risk for PTSD. In contrast, triglycerides (TG) at baseline were significantly higher in patients with PTSD than in those without PTSD at 6 months post-MVA and were positively associated with risk for PTSD. There was no clear association between low-density lipoprotein cholesterol or total cholesterol and risk for PTSD. In conclusion, low HDL-C and high TG may be risk factors for PTSD. Determining lipid profiles might help identify those at risk for PTSD after experiencing trauma. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

The Predictive Effects of Early Pregnancy Lipid Profiles and Fasting Glucose on the Risk of Gestational Diabetes Mellitus Stratified by Body Mass Index.

PubMed

Wang, Chen; Zhu, Weiwei; Wei, Yumei; Su, Rina; Feng, Hui; Lin, Li; Yang, Huixia

2016-01-01

This study aimed at evaluating the predictive effects of early pregnancy lipid profiles and fasting glucose on the risk of gestational diabetes mellitus (GDM) in patients stratified by prepregnancy body mass index (p-BMI) and to determine the optimal cut-off values of each indicator for different p-BMI ranges. A retrospective system cluster sampling survey was conducted in Beijing during 2013 and a total of 5,265 singleton pregnancies without prepregnancy diabetes were included. The information for each participant was collected individually using questionnaires and medical records. Logistic regression analysis and receiver operator characteristics analysis were used in the analysis. Outcomes showed that potential markers for the prediction of GDM include early pregnancy lipid profiles (cholesterol, triacylglycerols, low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratios [LDL-C/HDL-C], and triglyceride to high-density lipoprotein cholesterol ratios [TG/HDL-C]) and fasting glucose, of which fasting glucose level was the most accurate indicator. Furthermore, the predictive effects and cut-off values for these factors varied according to p-BMI. Thus, p-BMI should be a consideration for the risk assessment of pregnant patients for GDM development.

A Robust Mass Estimator for Dark Matter Subhalo Perturbations in Strong Gravitational Lenses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Minor, Quinn E.; Kaplinghat, Manoj; Li, Nan

A few dark matter substructures have recently been detected in strong gravitational lenses through their perturbations of highly magnified images. We derive a characteristic scale for lensing perturbations and show that they are significantly larger than the perturber’s Einstein radius. We show that the perturber’s projected mass enclosed within this radius, scaled by the log-slope of the host galaxy’s density profile, can be robustly inferred even if the inferred density profile and tidal radius of the perturber are biased. We demonstrate the validity of our analytic derivation using several gravitational lens simulations where the tidal radii and the inner log-slopesmore » of the density profile of the perturbing subhalo are allowed to vary. By modeling these simulated data, we find that our mass estimator, which we call the effective subhalo lensing mass, is accurate to within about 10% or smaller in each case, whereas the inferred total subhalo mass can potentially be biased by nearly an order of magnitude. We therefore recommend that the effective subhalo lensing mass be reported in future lensing reconstructions, as this will allow for a more accurate comparison with the results of dark matter simulations.« less

A Kinematical Detection of Two Embedded Jupiter-mass Planets in HD 163296

NASA Astrophysics Data System (ADS)

Teague, Richard; Bae, Jaehan; Bergin, Edwin A.; Birnstiel, Tilman; Foreman-Mackey, Daniel

2018-06-01

We present the first kinematical detection of embedded protoplanets within a protoplanetary disk. Using archival Atacama Large Millimetre Array (ALMA) observations of HD 163296, we demonstrate a new technique to measure the rotation curves of CO isotopologue emission to sub-percent precision relative to the Keplerian rotation. These rotation curves betray substantial deviations caused by local perturbations in the radial pressure gradient, likely driven by gaps carved in the gas surface density by Jupiter-mass planets. Comparison with hydrodynamic simulations shows excellent agreement with the gas rotation profile when the disk surface density is perturbed by two Jupiter-mass planets at 83 and 137 au. As the rotation of the gas is dependent upon the pressure of the total gas component, this method provides a unique probe of the gas surface density profile without incurring significant uncertainties due to gas-to-dust ratios or local chemical abundances that plague other methods. Future analyses combining both methods promise to provide the most accurate and robust measures of embedded planetary mass. Furthermore, this method provides a unique opportunity to explore wide-separation planets beyond the mm continuum edge and to trace the gas pressure profile essential in modeling grain evolution in disks.

Constructing the AdS dual of a Fermi liquid: AdS black holes with Dirac hair

NASA Astrophysics Data System (ADS)

Čubrović, Mihailo; Zaanen, Jan; Schalm, Koenraad

2011-10-01

We provide evidence that the holographic dual to a strongly coupled charged Fermi liquid has a non-zero fermion density in the bulk. We show that the pole-strength of the stable quasiparticle characterizing the Fermi surface is encoded in the AdS probability density of a single normalizable fermion wavefunction in AdS. Recalling Migdal's theorem which relates the pole strength to the Fermi-Dirac characteristic discontinuity in the number density at ω F , we conclude that the AdS dual of a Fermi liquid is described by occupied on-shell fermionic modes in AdS. Encoding the occupied levels in the total spatially averaged probability density of the fermion field directly, we show that an AdS Reissner-Nordström black holein a theory with charged fermions has a critical temperature, at which the system undergoes a first-order transition to a black hole with a non-vanishing profile for the bulk fermion field. Thermodynamics and spectral analysis support that the solution with non-zero AdS fermion-profile is the preferred ground state at low temperatures.

Poloidal asymmetries in edge transport barriersa)

NASA Astrophysics Data System (ADS)

Churchill, R. M.; Theiler, C.; Lipschultz, B.; Hutchinson, I. H.; Reinke, M. L.; Whyte, D.; Hughes, J. W.; Catto, P.; Landreman, M.; Ernst, D.; Chang, C. S.; Hager, R.; Hubbard, A.; Ennever, P.; Walk, J. R.

2015-05-01

Measurements of impurities in Alcator C-Mod indicate that in the pedestal region, significant poloidal asymmetries can exist in the impurity density, ion temperature, and main ion density. In light of the observation that ion temperature and electrostatic potential are not constant on a flux surface [Theiler et al., Nucl. Fusion 54, 083017 (2014)], a technique based on total pressure conservation to align profiles measured at separate poloidal locations is presented and applied. Gyrokinetic neoclassical simulations with XGCa support the observed large poloidal variations in ion temperature and density, and that the total pressure is approximately constant on a flux surface. With the updated alignment technique, the observed in-out asymmetry in impurity density is reduced from previous publishing [Churchill et al., Nucl. Fusion 53, 122002 (2013)], but remains substantial ( n z , H / n z , L ˜ 6 ). Candidate asymmetry drivers are explored, showing that neither non-uniform impurity sources nor localized fluctuation-driven transport are able to explain satisfactorily the impurity density asymmetry. Since impurity density asymmetries are only present in plasmas with strong electron density gradients, and radial transport timescales become comparable to parallel transport timescales in the pedestal region, it is suggested that global transport effects relating to the strong electron density gradients in the pedestal are the main driver for the pedestal in-out impurity density asymmetry.

A theoretical study of heterojunction and graded band gap type solar cells

NASA Technical Reports Server (NTRS)

Sutherland, J. E.; Hauser, J. R.

1977-01-01

A computer program was designed for the analysis of variable composition solar cells and applied to several proposed solar cell structures using appropriate semiconductor materials. The program simulates solar cells made of a ternary alloy of two binary semiconductors with an arbitrary composition profile, and an abrupt or Gaussian doping profile of polarity n-on-p or p-on-n with arbitrary doping levels. Once the device structure is specified, the program numerically solves a complete set of differential equations and calculates electrostatic potential, quasi-Fermi levels, carrier concentrations and current densities, total current density and efficiency as functions of terminal voltage and position within the cell. These results are then recorded by computer in tabulated or plotted form for interpretation by the user.

Core or Cusps: The Central Dark Matter Profile of a Strong Lensing Cluster with a Bright Central Image at Redshift 1 [Core or Cusps: The Central Dark Matter Profile of a Redshift One Strong Lensing Cluster with a Bright Central Image

DOE PAGES

Collett, Thomas E.; Buckley-Geer, Elizabeth; Lin, Huan; ...

2017-07-10

Here, we report on SPT-CLJ2011-5228, a giant system of arcs created by a cluster at z = 1.06. The arc system is notable for the presence of a bright central image. The source is a Lyman break galaxy at z s = 2.39 and the mass enclosed within the Einstein ring of radius 14 arcsec ismore » $$\\sim {10}^{14.2}\\ {M}_{\\odot }$$. We perform a full reconstruction of the light profile of the lensed images to precisely infer the parameters of the mass distribution. The brightness of the central image demands that the central total density profile of the lens be shallow. By fitting the dark matter as a generalized Navarro–Frenk–White profile—with a free parameter for the inner density slope—we find that the break radius is $${270}_{-76}^{+48}$$ kpc, and that the inner density falls with radius to the power –0.38 ± 0.04 at 68% confidence. Such a shallow profile is in strong tension with our understanding of relaxed cold dark matter halos; dark matter-only simulations predict that the inner density should fall as $${r}^{-1}$$. The tension can be alleviated if this cluster is in fact a merger; a two-halo model can also reconstruct the data, with both clumps (density varying as $${r}^{-0.8}$$ and $${r}^{-1.0}$$) much more consistent with predictions from dark matter-only simulations. At the resolution of our Dark Energy Survey imaging, we are unable to choose between these two models, but we make predictions for forthcoming Hubble Space Telescope imaging that will decisively distinguish between them.« less

Core or Cusps: The Central Dark Matter Profile of a Strong Lensing Cluster with a Bright Central Image at Redshift 1 [Core or Cusps: The Central Dark Matter Profile of a Redshift One Strong Lensing Cluster with a Bright Central Image

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collett, Thomas E.; Buckley-Geer, Elizabeth; Lin, Huan

Here, we report on SPT-CLJ2011-5228, a giant system of arcs created by a cluster at z = 1.06. The arc system is notable for the presence of a bright central image. The source is a Lyman break galaxy at z s = 2.39 and the mass enclosed within the Einstein ring of radius 14 arcsec ismore » $$\\sim {10}^{14.2}\\ {M}_{\\odot }$$. We perform a full reconstruction of the light profile of the lensed images to precisely infer the parameters of the mass distribution. The brightness of the central image demands that the central total density profile of the lens be shallow. By fitting the dark matter as a generalized Navarro–Frenk–White profile—with a free parameter for the inner density slope—we find that the break radius is $${270}_{-76}^{+48}$$ kpc, and that the inner density falls with radius to the power –0.38 ± 0.04 at 68% confidence. Such a shallow profile is in strong tension with our understanding of relaxed cold dark matter halos; dark matter-only simulations predict that the inner density should fall as $${r}^{-1}$$. The tension can be alleviated if this cluster is in fact a merger; a two-halo model can also reconstruct the data, with both clumps (density varying as $${r}^{-0.8}$$ and $${r}^{-1.0}$$) much more consistent with predictions from dark matter-only simulations. At the resolution of our Dark Energy Survey imaging, we are unable to choose between these two models, but we make predictions for forthcoming Hubble Space Telescope imaging that will decisively distinguish between them.« less

Effects of walnut oil on lipid profiles in hyperlipidemic type 2 diabetic patients: a randomized, double-blind, placebo-controlled trial.

PubMed

Zibaeenezhad, M J; Farhadi, P; Attar, A; Mosleh, A; Amirmoezi, F; Azimi, A

2017-04-10

The role of herbal medicine is now well documented in preventing and controlling diabetes mellitus. The main aim of this study was to evaluate the effects of walnut oil consumption on lipid profiles of hyperlipidemic patients with type 2 diabetes. In a randomized, double-blind, placebo-controlled clinical trial, 100 hyperlipidemic type 2 diabetic patients aged 35-75 years were assigned to receive 15 cc Persian walnut oil or placebo every day for 90 days. The primary outcomes were the lipid profiles. Consumption of walnut oil by type 2 hyperlipidemic diabetic patients resulted in a significant decrease in total cholesterol levels (treatment difference (TD)=-30.04, P<0.001), triglyceride (TG) level (TD=-15.04, P=0.021), low-density lipoprotein (LDL) level (TD=-30.44, P<0.001) and total cholesterol to high-density lipoprotein (HDL) ratio (TD=-0.72, P<0.001) compared to the control group. There was a trend toward increasing HDL level with consumption of walnut oil (TD=2.28, P=0.06). Frequency of patients reaching a LDL level below 100 was higher in the case group (20 vs 0%). Addition of walnut oil in the daily diet of type 2 diabetic patients improves lipid profiles. Thus, it may be associated with a coronary artery disease risk factor modulation. Also, walnut oil may serve as a helpful natural remedy for hyperlipidemic patients with type 2 diabetes.

The Outer Profile of the Draco Dwarf Spheroidal Galaxy: Measuring the Mass-Loss Rate

NASA Astrophysics Data System (ADS)

Armandroff, Taft; Pryor, Carlton; Olszewski, Edward

1999-02-01

The existence and properties of dark matter in dwarf galaxies have fundamental implications for cosmology and galaxy formation. We are engaged in a long-term effort to observe and model the structure, kinematics, and mass-to-light ratios of the Draco and UMi dwarf spheroidal (dSph) galaxies. Here we propose to extend our work with a search for outlying members and tidal tails of the Draco dSph galaxy, motivated by observational, theoretical, and technical advances. Recent sophisticated modeling of tidal interactions with the Galactic potential clarifies the interpretation of tidal tails and shows how to calculate the rate at which stars have been lost from a dSph or globular from the density profile of the tidal debris. Also, the radius of the transition between bound and unbound stars yields the outer boundary and total mass of the dark matter halos in the dSphs. While central mass densities and central mass-to-light ratios are generally available for dSphs, determination of their total masses (like those of any galaxy) has remained elusive. We will map a 24 square degree area along the major axis of Draco, plus six square degrees of background. Use of a 3-filter technique will result in an unprecedentedly clean census of distant Draco stars and, thus, a major-axis density profile to a radius of ~6°. Our long-term goal is to investigate the kinematics of the outer members and tidal-tail stars in order to compare in detail with the models.

Serum lipids, recent suicide attempt and recent suicide status in patients with major depressive disorder.

PubMed

Baek, Ji Hyun; Kang, Eun-Suk; Fava, Maurizio; Mischoulon, David; Nierenberg, Andrew A; Yu, Bum-Hee; Lee, Dongsoo; Jeon, Hong Jin

2014-06-03

Major depressive disorder (MDD) is associated with suicide. Although several studies have reported its association with low serum lipid, few studies have investigated relationships between current suicidality and lipid profiles, comparing with other blood measures in MDD patients. The study population consisted of 555 subjects with MDD who were ≥ 18 years old, evaluated by the Mini International Neuropsychiatric Interview (MINI) with the suicidality module. At the evaluation visit, we measured serum lipid profiles including total cholesterol, triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and very low-density lipoprotein (VLDL), and blood measures such as fasting glucose, total protein, albumin, blood urea nitrogen, creatinine, thyroid hormones, red and white blood cells, platelet count, hemoglobin, and hematocrit. Recent attempters who had attempted suicide within the past month showed significantly lower TG and higher HDL levels than lifetime and never attempters, using Tukey's post-hoc analysis. Recent attempters exhibited lower TG and higher HDL than those with recent suicide ideation and wish to self-harm and those without previous attempt. Linear regression analysis revealed that TG was negatively associated with current suicidality scores (β = -0.187, p = 0.039), whereas VLDL was positively associated with the recent suicide status (β = 0.198, p = 0.032) after controlling for age and sex. There were no significant differences between the groups in terms of other serum lipid profiles and blood measures. Low serum TG, high HDL and VLDL levels are associated with recent suicide attempt or recent suicide status in patients with MDD. Copyright © 2014 Elsevier Inc. All rights reserved.

Lipid, Fatty Acid and Energy Density Profiles of White Sharks: Insights into the Feeding Ecology and Ecophysiology of a Complex Top Predator

PubMed Central

Pethybridge, Heidi R.; Parrish, Christopher C.; Bruce, Barry D.; Young, Jock W.; Nichols, Peter D.

2014-01-01

Lipids are major sources of metabolic energy in sharks and are closely linked to environmental conditions and biological cycles, such as those related to diet, reproduction and migration. In this study, we report for the first time, the total lipid content, lipid class composition and fatty acid profiles of muscle and liver tissue of white sharks, Carcharodon carcharias, of various lengths (1.5–3.9 m), sampled at two geographically separate areas off southern and eastern Australia. Muscle tissue was low in total lipid content (<0.9% wet mass, wm) and was dominated by phospholipids (>90% of total lipid) and polyunsaturated fatty acids (34±12% of total fatty acids). In contrast, liver was high in total lipid which varied between 51–81% wm and was dominated by triacylglycerols (>93%) and monounsaturated fatty acids (36±12%). With knowledge of total lipid and dry tissue mass, we estimated the energy density of muscle (18.4±0.1 kJ g−1 dm) and liver (34.1±3.2 kJ g−1 dm), demonstrating that white sharks have very high energetic requirements. High among-individual variation in these biochemical parameters and related trophic markers were observed, but were not related to any one biological or environmental factor. Signature fatty acid profiles suggest that white sharks over the size range examined are generalist predators with fish, elasmobranchs and mammalian blubber all contributing to the diet. The ecological applications and physiological influences of lipids in white sharks are discussed along with recommendations for future research, including the use of non-lethal sampling to examine the nutritional condition, energetics and dietary relationships among and between individuals. Such knowledge is fundamental to better understand the implications of environmental perturbations on this iconic and threatened species. PMID:24871223

Lipid, fatty acid and energy density profiles of white sharks: insights into the feeding ecology and ecophysiology of a complex top predator.

PubMed

Pethybridge, Heidi R; Parrish, Christopher C; Bruce, Barry D; Young, Jock W; Nichols, Peter D

2014-01-01

Lipids are major sources of metabolic energy in sharks and are closely linked to environmental conditions and biological cycles, such as those related to diet, reproduction and migration. In this study, we report for the first time, the total lipid content, lipid class composition and fatty acid profiles of muscle and liver tissue of white sharks, Carcharodon carcharias, of various lengths (1.5-3.9 m), sampled at two geographically separate areas off southern and eastern Australia. Muscle tissue was low in total lipid content (<0.9% wet mass, wm) and was dominated by phospholipids (>90% of total lipid) and polyunsaturated fatty acids (34±12% of total fatty acids). In contrast, liver was high in total lipid which varied between 51-81% wm and was dominated by triacylglycerols (>93%) and monounsaturated fatty acids (36±12%). With knowledge of total lipid and dry tissue mass, we estimated the energy density of muscle (18.4±0.1 kJ g-1 dm) and liver (34.1±3.2 kJ g-1 dm), demonstrating that white sharks have very high energetic requirements. High among-individual variation in these biochemical parameters and related trophic markers were observed, but were not related to any one biological or environmental factor. Signature fatty acid profiles suggest that white sharks over the size range examined are generalist predators with fish, elasmobranchs and mammalian blubber all contributing to the diet. The ecological applications and physiological influences of lipids in white sharks are discussed along with recommendations for future research, including the use of non-lethal sampling to examine the nutritional condition, energetics and dietary relationships among and between individuals. Such knowledge is fundamental to better understand the implications of environmental perturbations on this iconic and threatened species.

Effect of Vitamin D, Calcium and Multiple Micronutrients Supplementation on Lipid Profile in Pre-menopausal Bangladeshi Garment Factory Workers with Hypovitaminosis D

PubMed Central

Shamim, Abu Ahmed; Ahmed, Abu; Akhtaruzzaman, Mohammad; Kärkkäinen, Merja; Lamberg-Allardt, Christel

2014-01-01

ABSTRACT Elevated total cholesterol and low-density lipoprotein cholesterol in sera are both well-known risk factors of coronary heart disease. Adequate vitamin D status is important for optimal function of many organs and tissues of our body. There is continuing controversy about the effect of adequate vitamin D consumption on serum lipids and lipoproteins. The present study assessed the effect of vitamin D, calcium and multiple micronutrients supplementation on the lipid profile in Bangladeshi young female garment factory workers who have hypovitaminosis D. This placebo-controlled intervention trial conducted over a period of one year randomly assigned a total of 200 apparently healthy subjects aged 16-36 years to 4 groups. The subjects received daily supplements of 400 IU of vitamin D (VD group) or 400 IU of vitamin D+600 mg of calcium lactate (VD-Ca group), or multiple micronutrients with 400 IU of vitamin-D+600 mg of calcium lactate (MMN-VD-Ca group), or the group consuming placebo (PL group). Serum concentrations of lipid and lipoprotein, 25-hydroxyvitamin D (25OHD) and intact parathyroid hormone (iPTH) were measured at baseline and after one year of follow-up. No significant changes in the serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), LDL-C/HDL-C ratio were observed in the supplemented groups compared to the placebo group. Supplementation had a positive effect (p<0.05) on very low-density lipoprotein cholesterol (VLDL-C) and triacylglycerol (TAG). A negative correlation between changes in serum iPTH and HDL-C was observed, which indicated that subjects with the greatest decline in S-iPTH had the greatest increase in HDL-C. The results suggest that consumption of adequate vitamin D with calcium or MMN for one-year may have no impact on serum lipid profile in the subjects studied. Longer-term clinical trials with different doses of supplemental vitamin D are warranted in evaluating the effect of intervention. PMID:25895202

Effect of vitamin D, calcium and multiple micronutrients supplementation on lipid profile in pre-menopausal Bangladeshi garment factory workers with hypovitaminosis D.

PubMed

Islam, Md Zahirul; Shamim, Abu Ahmed; Akhtaruzzaman, Mohammad; Kärkkäinen, Merja; Lamberg-Allardt, Christel

2014-12-01

Elevated total cholesterol and low-density lipoprotein cholesterol in sera are both well-known risk factors of coronary heart disease. Adequate vitamin D status is important for optimal function of many organs and tissues of our body. There is continuing controversy about the effect of adequate vitamin D consumption on serum lipids and lipoproteins. The present study assessed the effect of vitamin D, calcium and multiple micronutrients supplementation on the lipid profile in Bangladeshi young female garment factory workers who have hypovitaminosis D. This placebo-controlled intervention trial conducted over a period of one year randomly assigned a total of 200 apparently healthy subjects aged 16-36 years to 4 groups. The subjects received daily supplements of 400 IU of vitamin D (VD group) or 400 IU of vitamin D+600 mg of calcium lactate (VD-Ca group), or multiple micronutrients with 400 IU of vitamin-D+600 mg of calcium lactate (MMN-VD-Ca group), or the group consuming placebo (PL group). Serum concentrations of lipid and lipoprotein, 25-hydroxyvitamin D (25OHD) and intact parathyroid hormone (iPTH) were measured at baseline and after one year of follow-up. No significant changes in the serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), LDL-C/HDL-C ratio were observed in the supplemented groups compared to the placebo group. Supplementation had a positive effect (p<0.05) on very low-density-lipoprotein cholesterol (VLDL-C) and triacylglycerol (TAG). A negative correlation between changes in serum iPTH and HDL-C was observed, which indicated that subjects with the greatest decline in S-iPTH had the greatest increase in HDL-C. The results suggest that consumption of adequate vitamin D with calcium or MMN for one-year may have no impact on serum lipid profile in the subjects studied. Longer-term clinical trials with different doses of supplemental vitamin D are warranted in evaluating the effect of intervention.

Real-time feedback control of the plasma density profile on ASDEX Upgrade

NASA Astrophysics Data System (ADS)

Mlynek, A.; Reich, M.; Giannone, L.; Treutterer, W.; Behler, K.; Blank, H.; Buhler, A.; Cole, R.; Eixenberger, H.; Fischer, R.; Lohs, A.; Lüddecke, K.; Merkel, R.; Neu, G.; Ryter, F.; Zasche, D.; ASDEX Upgrade Team

2011-04-01

The spatial distribution of density in a fusion experiment is of significant importance as it enters in numerous analyses and contributes to the fusion performance. The reconstruction of the density profile is therefore commonly done in offline data analysis. In this paper, we present an algorithm which allows for density profile reconstruction from the data of the submillimetre interferometer and the magnetic equilibrium in real-time. We compare the obtained results to the profiles yielded by a numerically more complex offline algorithm. Furthermore, we present recent ASDEX Upgrade experiments in which we used the real-time density profile for active feedback control of the shape of the density profile.

Z-Scan Analysis: a New Method to Determine the Oxidative State of Low-Density Lipoprotein and Its Association with Multiple Cardiometabolic Biomarkers

NASA Astrophysics Data System (ADS)

de Freitas, Maria Camila Pruper; Figueiredo Neto, Antonio Martins; Giampaoli, Viviane; da Conceição Quintaneiro Aubin, Elisete; de Araújo Lima Barbosa, Milena Maria; Damasceno, Nágila Raquel Teixeira

2016-04-01

The great atherogenic potential of oxidized low-density lipoprotein has been widely described in the literature. The objective of this study was to investigate whether the state of oxidized low-density lipoprotein in human plasma measured by the Z-scan technique has an association with different cardiometabolic biomarkers. Total cholesterol, high-density lipoprotein cholesterol, triacylglycerols, apolipoprotein A-I and apolipoprotein B, paraoxonase-1, and glucose were analyzed using standard commercial kits, and low-density lipoprotein cholesterol was estimated using the Friedewald equation. A sandwich enzyme-linked immunosorbent assay was used to detect electronegative low-density lipoprotein. Low-density lipoprotein and high-density lipoprotein sizes were determined by Lipoprint® system. The Z-scan technique was used to measure the non-linear optical response of low-density lipoprotein solution. Principal component analysis and correlations were used respectively to resize the data from the sample and test association between the θ parameter, measured with the Z-scan technique, and the principal component. A total of 63 individuals, from both sexes, with mean age 52 years (±11), being overweight and having high levels of total cholesterol and low levels of high-density lipoprotein cholesterol, were enrolled in this study. A positive correlation between the θ parameter and more anti-atherogenic pattern for cardiometabolic biomarkers together with a negative correlation for an atherogenic pattern was found. Regarding the parameters related with an atherogenic low-density lipoprotein profile, the θ parameter was negatively correlated with a more atherogenic pattern. By using Z-scan measurements, we were able to find an association between oxidized low-density lipoprotein state and multiple cardiometabolic biomarkers in samples from individuals with different cardiovascular risk factors.

Regional body fat distribution and metabolic profile in postmenopausal women.

PubMed

Piché, Marie-Eve; Lapointe, Annie; Weisnagel, S John; Corneau, Louise; Nadeau, André; Bergeron, Jean; Lemieux, Simone

2008-08-01

The aim of the study was to examine how body fat distribution variables were associated with metabolic parameters in a sample of 113 postmenopausal women not receiving hormone therapy (56.9 +/- 4.4 years, 28.4 +/- 5.1 kg/m(2)). Body fat distribution variables (visceral adipose tissue [AT], subcutaneous AT, and total midthigh AT) were measured using computed tomography; body fat mass was assessed by hydrostatic weighing; insulin sensitivity was determined with the euglycemic-hyperinsulinemic clamp; fasting plasma glucose (FPG) and 2-hour plasma glucose (2hPG) concentrations were measured by a 75-g oral glucose load; and (high-sensitivity) C-reactive protein (hs-CRP) was measured using a highly sensitive assay. After controlling for fat mass, visceral AT was positively associated with plasma triglyceride, hs-CRP, FPG, and 2hPG, and negatively associated with high-density lipoprotein cholesterol (HDL-C) and insulin sensitivity. Total midthigh AT was negatively associated with apolipoprotein B, FPG, and 2hPG, and positively associated with insulin sensitivity. Stepwise multiple regression analyses including abdominal visceral AT, subcutaneous AT and total midthigh AT as independent variables showed that abdominal visceral AT best predicted the variance in plasma triglyceride, HDL-C, low-density lipoprotein peak particle size, hs-CRP, FPG, 2hPG, and insulin sensitivity. Abdominal subcutaneous AT was a significant predictor of only insulin sensitivity, whereas total midthigh AT predicted HDL-C, low-density lipoprotein peak particle size, and apolipoprotein B. These multivariate analyses also indicated that total midthigh AT was favorably related to these outcomes, whereas abdominal visceral AT and subcutaneous AT were unfavorably related. These results confirmed that abdominal visceral fat is a critical correlate of metabolic parameters in postmenopausal women. In addition, a higher proportion of AT located in the total midthigh depot is associated with a favorable metabolic profile.

Phase-plane analysis of the totally asymmetric simple exclusion process with binding kinetics and switching between antiparallel lanes

PubMed Central

Kuan, Hui-Shun; Betterton, Meredith D.

2016-01-01

Motor protein motion on biopolymers can be described by models related to the totally asymmetric simple exclusion process (TASEP). Inspired by experiments on the motion of kinesin-4 motors on antiparallel microtubule overlaps, we analyze a model incorporating the TASEP on two antiparallel lanes with binding kinetics and lane switching. We determine the steady-state motor density profiles using phase-plane analysis of the steady-state mean field equations and kinetic Monte Carlo simulations. We focus on the density-density phase plane, where we find an analytic solution to the mean field model. By studying the phase-space flows, we determine the model’s fixed points and their changes with parameters. Phases previously identified for the single-lane model occur for low switching rate between lanes. We predict a multiple coexistence phase due to additional fixed points that appear as the switching rate increases: switching moves motors from the higher-density to the lower-density lane, causing local jamming and creating multiple domain walls. We determine the phase diagram of the model for both symmetric and general boundary conditions. PMID:27627345

A Theoretical Study of Flow Structure and Radiation for Multiphase Turbulent Diffusion Flames

DTIC Science & Technology

1990-03-01

density function. According to the axial void fraction profile in Fig. 24, the flame length (the total penetration length) extends to x/d=150. By referring...temperature because of subcooling effect. Decreasing liquid temperature will increase condensation which in turn reduces the flame length as defined by

A more accurate profile of Achyrocline satureioides hypocholesterolemic activity.

PubMed

Espiña, Débora Corrêa; Carvalho, Fabiano Barbosa; Zanini, Daniela; Schlemmer, Josiane Bizzi; Coracini, Juliane Dors; Rubin, Maribel Antonello; Morsch, Vera Maria; Schetinger, Maria Rosa Chitolina; Leal, Daniela Bitencourt Rosa; Baiotto, Cléia Rosani; Jaques, Jeandre Augusto dos Santos

2012-06-01

The aim of this study was to investigate the effect of the aqueous extract (AE) of Achyrocline satureioides on serum lipid profile, liver oxidative profile and Na(+),K(+)-ATPase activity of rats submitted to a hyperlipidic diet. The animals were divided into four groups: control (C), AE 10% (A(10)), hyperlipidic (H) and hyperlipidic/AE 10% (HA(10)). In serum, we measured the levels of total cholesterol (TC), high-density lipoprotein, very-low-density lipoprotein, low-density lipoprotein (LDL) and triglyceride (TG). In liver homogenates, we measured the thiobarbituric acid reactive substances, the carbonyl proteins, the non-protein thiols (NPSHs) and the activity of superoxide dismutase, catalase (CAT) and Na(+),K(+)-ATPase. We observed a significant increase in the TC and LDL levels in the H group. A. satureioides prevented these effects, decreased the TG levels in the HA(10) group and increased the NPSH levels in the A(10) and HA(10) groups. The H group showed an increase in the carbonyl protein level and a decrease in CAT and Na(+),K(+)-ATPase activities. With the use of this model, results show that increased levels of lipids are related to a redox imbalance in the liver, which is also related to the inhibition of Na(+),K(+)-ATPase activity, and that chronic administration of the AE of A. satureioides is capable of changing this profile. Copyright © 2012 John Wiley & Sons, Ltd.

State-dependent alterations of lipid profiles in patients with bipolar disorder.

PubMed

Huang, Yu-Jui; Tsai, Shang-Ying; Chung, Kuo-Hsuan; Chen, Pao-Huan; Huang, Shou-Hung; Kuo, Chian-Jue

2018-07-01

Objective Serum lipid levels may be associated with the affective severity of bipolar disorder, but data on lipid profiles in Asian patients with bipolar disorder and the lipid alterations in different states of opposite polarities are scant. We investigated the lipid profiles of patients in the acute affective, partial, and full remission state in bipolar mania and depression. Methods The physically healthy patients aged between 18 and 45 years with bipolar I disorder, as well as age-matched healthy normal controls were enrolled. We compared the fasting blood levels of glucose, cholesterol, triglyceride, low-density lipoprotein, and high-density lipoprotein of manic or depressed patients in the acute phase and subsequent partial and full remission with those of their normal controls. Results A total of 32 bipolar manic patients (12 women and 20 men), 32 bipolar depressed participants (18 women and 14 men), and 64 healthy control participants took part in this study. The mean cholesterol level in acute mania was significantly lower than that in acute depression (p < 0.025). The lowest rate of dyslipidemia (hypertriglyceridemia or low high-density lipoprotein cholesterol) was observed in acute bipolar mania. Conclusion Circulating lipid profiles may be easily affected by affective states. The acute manic state may be accompanied by state-dependent lower cholesterol and triglyceride levels relative to that in other mood states.

Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts.

PubMed

Tynkkynen, Juho; Chouraki, Vincent; van der Lee, Sven J; Hernesniemi, Jussi; Yang, Qiong; Li, Shuo; Beiser, Alexa; Larson, Martin G; Sääksjärvi, Katri; Shipley, Martin J; Singh-Manoux, Archana; Gerszten, Robert E; Wang, Thomas J; Havulinna, Aki S; Würtz, Peter; Fischer, Krista; Demirkan, Ayse; Ikram, M Arfan; Amin, Najaf; Lehtimäki, Terho; Kähönen, Mika; Perola, Markus; Metspalu, Andres; Kangas, Antti J; Soininen, Pasi; Ala-Korpela, Mika; Vasan, Ramachandran S; Kivimäki, Mika; van Duijn, Cornelia M; Seshadri, Sudha; Salomaa, Veikko

2018-06-01

Metabolite, lipid, and lipoprotein lipid profiling can provide novel insights into mechanisms underlying incident dementia and Alzheimer's disease. We studied eight prospective cohorts with 22,623 participants profiled by nuclear magnetic resonance or mass spectrometry metabolomics. Four cohorts were used for discovery with replication undertaken in the other four to avoid false positives. For metabolites that survived replication, combined association results are presented. Over 246,698 person-years, 995 and 745 cases of incident dementia and Alzheimer's disease were detected, respectively. Three branched-chain amino acids (isoleucine, leucine, and valine), creatinine and two very low density lipoprotein (VLDL)-specific lipoprotein lipid subclasses were associated with lower dementia risk. One high density lipoprotein (HDL; the concentration of cholesterol esters relative to total lipids in large HDL) and one VLDL (total cholesterol to total lipids ratio in very large VLDL) lipoprotein lipid subclass was associated with increased dementia risk. Branched-chain amino acids were also associated with decreased Alzheimer's disease risk and the concentration of cholesterol esters relative to total lipids in large HDL with increased Alzheimer's disease risk. Further studies can clarify whether these molecules play a causal role in dementia pathogenesis or are merely markers of early pathology. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Effects of Chinese Dietary Pattern of Fat Content, n-6/n-3 Polyunsaturated Fatty Acid Ratio, and Cholesterol Content on Lipid Profile in Rats

PubMed Central

Zou, Xian-Guo; Huang, Yu-Hua; Xu, Tong-Cheng; Fan, Ya-Wei; Li, Jing

2018-01-01

This study aims to investigate the effect of Chinese diet pattern of fat content (30% or 36.06%), n-6/n-3 polyunsaturated fatty acid (PUFA) ratio (5 : 1 or 9 : 1), and cholesterol content (0.04 or 0.057 g/kg total diet) on lipid profile using a rat model. Results showed that rats' body weights (BWs) were controlled by the simultaneous intakes of cholesterol level of 0.04 g/kg total diet and n-6/n-3 ratio of 5 : 1. In addition, under high-fat diet, increased cholesterol feeding led to increased total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels and decreased triacylglycerols (TG) in rats' plasma. However, high density lipoprotein cholesterol (HDL-C) level and the ratios of HDL-C/LDL-C and HDL-C/TC in rats' plasma increased in response to simultaneous intakes of low n-6/n-3 ratio (5 : 1) and cholesterol (0.04 g/kg total diet) even under high-fat diet. Moreover, as the n-6/n-3 PUFA ratio in the diet decreased, the proportion of n-3 PUFAs increased in plasma, liver, and muscle and resulted in the decrease of n-6/n-3 PUFA ratio. PMID:29744358

Forming disc galaxies in major mergers - III. The effect of angular momentum on the radial density profiles of disc galaxies

NASA Astrophysics Data System (ADS)

Peschken, N.; Athanassoula, E.; Rodionov, S. A.

2017-06-01

We study the effect of angular momentum on the surface density profiles of disc galaxies, using high-resolution simulations of major mergers whose remnants have downbending radial density profiles (type II). As described in the previous papers of this series, in this scenario, most of the disc mass is acquired after the collision via accretion from a hot gaseous halo. We find that the inner and outer disc scalelengths, as well as the break radius, correlate with the total angular momentum of the initial merging system, and are larger for high-angular momentum systems. We follow the angular momentum redistribution in our simulated galaxies, and find that like the mass, the disc angular momentum is acquired via accretion, I.e. to the detriment of the gaseous halo. Furthermore, high-angular momentum systems give more angular momentum to their discs, which directly affects their radial density profile. Adding simulations of isolated galaxies to our sample, we find that the correlations are valid also for disc galaxies evolved in isolation. We show that the outer part of the disc at the end of the simulation is populated mainly by inside-out stellar migration, and that in galaxies with higher angular momentum, stars travel radially further out. This, however, does not mean that outer disc stars (in type II discs) were mostly born in the inner disc. Indeed, generally the break radius increases over time, and not taking this into account leads to overestimating the number of stars born in the inner disc.

Empirical analysis of electromagnetic profiles for groundwater prospecting in rural areas of Ibadan, southwestern Nigeria

NASA Astrophysics Data System (ADS)

Ehinola, O. A.; Opoola, A. O.

2005-05-01

The Slingram electromagnetic (EM) survey using a coil separation of 60 and 100 meters was carried out in 10 villages in Akinyele area of Ibadan, southwestern Nigeria to aid in the development of groundwater. Five main rock types including an undifferentiated gneiss complex (Su), biotite-garnet schist/gneiss (Bs), quartzite and quartz schist (Q), migmatised undifferentiated biotite/hornblende gneiss (M) and pegmatite/quartz vein (P) underlie the study area. A total of 31 EM profiles was made to accurately locate prospective borehole sites in the field. Four main groups with different behavioural pattern were categorized from the EM profiles. Group 1 is characterized by high density of positive (HDP) or high density of negative (HDN) real and imaginary curves, Group 2 by parallel real and imaginary curves intersecting with negligible amplitude (PNA), Group 3 by frequent intersection of high density of negative minima (FHN) real and imaginary curves, and Group 4 by separate and approximately parallel (SAP) real and imaginary curves. Qualitative pictures of the overburden thickness and the extent of fracturing have been proposed from these behavioural patterns. A comparison of the borehole yield with the overburden thickness and the level of fracturing show that borehole yield depends more on the fracture density than on the overburden thickness. Asymmetry of the anomaly was also found useful in the determination of the inclination of the conductor/fracture.

Red grape seed extract improves lipid profiles and decreases oxidized low-density lipoprotein in patients with mild hyperlipidemia.

PubMed

Razavi, Seyed-Mostafa; Gholamin, Sharareh; Eskandari, Ali; Mohsenian, Nakta; Ghorbanihaghjo, Amir; Delazar, Abbas; Rashtchizadeh, Nadereh; Keshtkar-Jahromi, Maryam; Argani, Hassan

2013-03-01

Hyperlipidemia can lead to atherosclerosis by lipoprotein deposition inside the vessel wall and oxidative stress induction that leads to the formation of atherosclerotic plaque. Oxidized low-density lipoprotein particles (Ox-LDL) have a key role in the pathogenesis of atherosclerosis. The lipid-lowering properties and antioxidants of the grape seed can be beneficial in atherosclerosis prevention. We conducted a randomized double-blind placebo-controlled crossover clinical trial. Fifty-two mildly hyperlipidemic individuals were divided into two groups that received either 200 mg/day of the red grape seed extract (RGSE) or placebo for 8 weeks. After an 8-week washout period, the groups were crossed over for another 8 weeks. Lipid profiles and Ox-LDL were measured at the beginning and the end of each phase. RGSE consumption reduced total cholesterol (-10.68±26.76 mg/dL, P=.015), LDL cholesterol (-9.66±23.92 mg/dL, P=.014), and Ox-LDL (-5.47±12.12 mg/dL, P=.008). While triglyceride and very low-density lipoprotein cholesterol were decreased and high-density lipoprotein cholesterol was increased by RGSE, the changes were not statistically significant. RGSE consumption decreases Ox-LDL and has beneficial effects on lipid profile-consequently decreasing the risk of atherosclerosis and cardiovascular disorders-in mild hyperlipidemic individuals.

Association between Metabolite Profiles, Metabolic Syndrome and Obesity Status.

PubMed

Allam-Ndoul, Bénédicte; Guénard, Frédéric; Garneau, Véronique; Cormier, Hubert; Barbier, Olivier; Pérusse, Louis; Vohl, Marie-Claude

2016-05-27

Underlying mechanisms associated with the development of abnormal metabolic phenotypes among obese individuals are not yet clear. Our aim is to investigate differences in plasma metabolomics profiles between normal weight (NW) and overweight/obese (Ov/Ob) individuals, with or without metabolic syndrome (MetS). Mass spectrometry-based metabolite profiling was used to compare metabolite levels between each group. Three main principal components factors explaining a maximum of variance were retained. Factor 1's (long chain glycerophospholipids) metabolite profile score was higher among Ov/Ob with MetS than among Ov/Ob and NW participants without MetS. This factor was positively correlated to plasma total cholesterol (total-C) and triglyceride levels in the three groups, to high density lipoprotein -cholesterol (HDL-C) among participants without MetS. Factor 2 (amino acids and short to long chain acylcarnitine) was positively correlated to HDL-C and negatively correlated with insulin levels among NW participants. Factor 3's (medium chain acylcarnitines) metabolite profile scores were higher among NW participants than among Ov/Ob with or without MetS. Factor 3 was negatively associated with glucose levels among the Ov/Ob with MetS. Factor 1 seems to be associated with a deteriorated metabolic profile that corresponds to obesity, whereas Factors 2 and 3 seem to be rather associated with a healthy metabolic profile.

The relation among steroid hormone levels, lipid profile and menopausal symptom severity.

PubMed

Kaya, Cihan; Cengiz, Hüseyin; Yeşil, Ali; Ekin, Murat; Yaşar, Levent

2017-12-01

Many postmenopausal women experience hot flashes, night sweats, non-specific emotional and psychological distresses. Our aim was to investigate the relation among steroid hormone levels, lipid profile and menopausal symptom severity using the menopause rating scale (MRS). A cross-sectional study was performed at our outpatient clinic with natural postmenopausal women. A total of 444 women were included in this study. The basic characteristics of the study population, such as age, gravidity, parity, time to menopause onset and body mass index (BMI) were recorded. Venous blood samples were collected from subjects after overnight fasting. The levels of high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, total cholesterol, triglyceride (TG), fasting plasma glucose, C-reactive protein, thyroid-stimulating hormone (TSH), cortisol, estradiol (E2), progesterone, testosterone and dehydroepiandrostenedione sulfate (DHEA-S) were analyzed. The MRS questionnaire validated for the Turkish population was used to assess the menopausal symptoms. There was a statistically significant difference between mild and severe total symptom scores for TG, and elevated TG levels were observed in the severe group (p = 0.04). Elevated testosterone levels were observed with severe psychological symptom and total symptom scores. There were significant differences in progesterone level in psychological, urogenital, and total scores and lower levels were seen in severe symptom groups. There was a significant negative correlation between urogenital symptom scores and progesterone levels (p < 0.001). Elevated levels of testosterone were related to severe psychological symptom and total menopausal symptom scores. A decrease in progesterone levels was related to high psychological, urogenital and total menopausal symptom scores. Elevated TG levels were also related to the total severe symptom scores.

Deficient serum 25-hydroxyvitamin D is associated with an atherogenic lipid profile: The Very Large Database of Lipids (VLDL-3) study.

PubMed

Lupton, Joshua R; Faridi, Kamil F; Martin, Seth S; Sharma, Sristi; Kulkarni, Krishnaji; Jones, Steven R; Michos, Erin D

2016-01-01

Cross-sectional studies have found an association between deficiencies in serum vitamin D, as measured by 25-hydroxyvitamin D (25[OH]D), and an atherogenic lipid profile. These studies have focused on a limited panel of lipid values including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). Our study examines the relationship between serum 25(OH)D and an extended lipid panel (Vertical Auto Profile) while controlling for age, gender, glycemic status, and kidney function. We used the Very Large Database of Lipids, which includes US adults clinically referred for analysis of their lipid profile from 2009 to 2011. Our study focused on 20,360 subjects who had data for lipids, 25(OH)D, age, gender, hemoglobin A1c, insulin, creatinine, and blood urea nitrogen. Subjects were split into groups based on serum 25(OH)D: deficient (<20 ng/mL), intermediate (≥ 20-30 ng/mL), and optimal (≥ 30 ng/mL). The deficient group was compared to the optimal group using multivariable linear regression. In multivariable-adjusted linear regression, deficient serum 25(OH)D was associated with significantly lower serum HDL-C (-5.1%) and higher total cholesterol (+9.4%), non-HDL-C (+15.4%), directly measured LDL-C (+13.5%), intermediate-density lipoprotein cholesterol (+23.7%), very low-density lipoprotein cholesterol (+19.0%), remnant lipoprotein cholesterol (+18.4%), and TG (+26.4%) when compared with the optimal group. Deficient serum 25(OH)D is associated with significantly lower HDL-C and higher directly measured LDL-C, intermediate-density lipoprotein cholesterol, very low-density lipoproteins cholesterol, remnant lipoprotein cholesterol, and TG. Future trials examining vitamin D supplementation and cardiovascular disease risk should consider using changes in an extended lipid panel as an additional outcome measurement. Copyright © 2016 National Lipid Association. Published by Elsevier Inc. All rights reserved.

Decoupling the deep: crop rotations, fertilization and soil physico-chemical properties down the profile

NASA Astrophysics Data System (ADS)

Hobley, Eleanor; Honermeier, Bernd; Don, Axel; Amelung, Wulf; Kögel-Knabner, Ingrid

2017-04-01

Crop fertilization provides vital plant nutrients (e.g. NPK) to ensure yield security but is also associated with negative environmental impacts. In particular, inorganic, mineral nitrogen (Nmin) fertilization leads to emissions during its energy intensive production as well as Nmin leaching to receiving waters. Incorporating legumes into crop rotations can provide organic N to the soil and subsequent crops, reducing the need for mineral N fertilizer and its negative environmental impacts. An added bonus is the potential to enhance soil organic carbon stocks, thereby reducing atmospheric CO2 concentrations. In this study we assessed the effects of legumes in rotation and fertilization regimes on the depth distribution - down to 1 m - of total soil nitrogen (Ntot), soil organic carbon (SOC) as well as isotopic composition (δ13C, δ15N), electrical conductivity and bulk density as well as agricultural yields at a long-term field experiment in Gießen, Germany. Fertilization had significant but small impacts on the soil chemical environment, most particularly the salt content of the soil, with PK fertilization increasing electrical conductivity throughout the soil profile. Similarly, fertilization resulted in a small reduction of soil pH throughout the soil profile. N fertilization, in particular, significantly increased yields, whereas PK fertilizer had only marginal yield effects, indicating that these systems are N limited. This N limitation was confirmed by significant yield benefits with leguminous crops in rotation, even in combination with mineral N fertilizer. The soil was physically and chemically influenced by the choice of crop rotation. Adding clover as a green mulch crop once every 4 years resulted in an enrichment of total N and SOC at the surface compared with fava beans and maize, but only in combination with PK fertilization. In contrast, fava beans and to a lesser extent maize in rotation lowered bulk densities in the subsoil compared with clover. This resulted in a reduction of N density at depth, which was not mirrored in C densities, indicating that fava beans decouple C and N cycles in the deep soil profile. We then tested whether these effects are a result of plant (i.e. enhanced rooting depth associated with lowered subsoil bulk density) or microbial (i.e. N-cycling and denitrification processes) activities, by investigating the isotopic signatures of C and N down the profile. Our results indicate that the selection of crop rotation influences soil C and N cycling and depth distribution. Although mineral N fertilizer has significant benefits for yield, the choice of crop rotation has a greater influence on soil C and N cycling and specifically the addition of leguminous plants into rotation can provide additional yield benefits and stability. Incorporating legumes into crop rotations affects soil physical and chemical properties and decouples C and N cycles in the deep soil profile, indicating different nutrient and water cycling processes in the deep soil profile.

Nimbus 7 solar backscatter ultraviolet (SBUV) ozone products user's guide

NASA Technical Reports Server (NTRS)

Fleig, Albert J.; Mcpeters, R. D.; Bhartia, P. K.; Schlesinger, Barry M.; Cebula, Richard P.; Klenk, K. F.; Taylor, Steven L.; Heath, Donald F.

1990-01-01

Three ozone tape products from the Solar Backscatter Ultraviolet (SBUV) experiment aboard Nimbus 7 were archived at the National Space Science Data Center. The experiment measures the fraction of incoming radiation backscattered by the Earth's atmosphere at 12 wavelengths. In-flight measurements were used to monitor changes in the instrument sensitivity. Total column ozone is derived by comparing the measurements with calculations of what would be measured for different total ozone amounts. The altitude distribution is retrieved using an optimum statistical technique for the inversion. The estimated initial error in the absolute scale for total ozone is 2 percent, with a 3 percent drift over 8 years. The profile error depends on latitude and height, smallest at 3 to 10 mbar; the drift increases with increasing altitude. Three tape products are described. The High Density SBUV (HDSBUV) tape contains the final derived products - the total ozone and the vertical ozone profile - as well as much detailed diagnostic information generated during the retrieval process. The Compressed Ozone (CPOZ) tape contains only that subset of HDSBUV information, including total ozone and ozone profiles, considered most useful for scientific studies. The Zonal Means Tape (ZMT) contains daily, weekly, monthly and quarterly averages of the derived quantities over 10 deg latitude zones.

Density stratification effects in sand-bed rivers

USGS Publications Warehouse

Wright, S.; Parker, G.

2004-01-01

In this paper the effects of density stratification in sand-bed rivers are studied by the application of a model of vertical velocity and concentration profiles, coupled through the use of a turbulence closure that retains the buoyancy terms. By making the governing equations dimensionless, it is revealed that the slope is the additional dimensionless parameter introduced by inclusion of the buoyancy terms. The primary new finding is that in general density stratification effects tend to be greater in large, low-slope rivers than in their smaller, steeper brethren. Under high flow conditions the total suspended load and size distribution of suspended sediment can be significantly affected by density stratification, and should be accounted for in any general theory of suspended transport. ?? ASCE.

Nordic Walking Training Causes a Decrease in Blood Cholesterol in Elderly Women Supplemented with Vitamin D.

PubMed

Prusik, Krzysztof; Kortas, Jakub; Prusik, Katarzyna; Mieszkowski, Jan; Jaworska, Joanna; Skrobot, Wojciech; Lipinski, Marcin; Ziemann, Ewa; Antosiewicz, Jedrzej

2018-01-01

Different studies have demonstrated that regular exercise can induce changes in the lipid profile, but results remain inconclusive. Available data suggest that correction of vitamin D deficiency can improve the lipid profile. In this study, we have hypothesized that Nordic Walking training will improve lipid profile in elderly women supplemented with vitamin D. A total of 109 elderly women (68 ± 5.12 years old) took part in the study. First group [experimental group (EG): 35 women] underwent 12 weeks of Nordic Walking (NW) training combined with vitamin D supplementation (4,000 IU/day), second group [supplementation group (SG): 48 women] was only supplemented with vitamin D (4,000 IU/day), and third group [control group (CG): 31 women] was not subject to any interventions. Blood analysis of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and 25-OH-D 3 was performed at baseline and after the 12 weeks of NW training. Additionally, a battery of field tests specifically developed for older adults was used to assess the components of functional fitness. The same blood analysis was repeated for the EG 6 months after the main experiment. After 12 weeks of NW training and vitamin D supplementation, in the EG a decrease in TC, LDL-C, and TG was observed. In the SG, no changes in the lipid profile were observed, whereas in the CG an increase in the HDL-C level was noticed. Positive physical fitness changes were only observed in the EG. Our obtained data confirmed baseline assumption that regular exercise induces positive alternations in lipid profile in elderly women supported by supplementation of vitamin D.

Dietary verbascoside supplementation in donkeys: effects on milk fatty acid profile during lactation, and serum biochemical parameters and oxidative markers.

PubMed

D'Alessandro, A G; Vizzarri, F; Palazzo, M; Martemucci, G

2017-09-01

Various uses of donkeys' milk have been recently proposed for human consumption on the basis of its nutritional characteristics. Improvements in milk fatty acid profile and animal oxidative status can be induced through dietary supplementation of phenolic compounds. The study aimed to evaluate in donkeys the effects of dietary supplementation with verbascoside (VB) on: (i) the fatty acid profile and vitamins A and E contents of milk during a whole lactation, and (ii) blood biochemical parameters and markers of oxidative status of the animals. At foaling, 12 lactating jennies were subdivided into two groups (n 6): control, without VB supplement; VB, receiving a lipid-encapsulated VB supplement. Gross composition, fatty acid profile and vitamins A and E contents in milk were assessed monthly over the 6 months of lactation. Serum total cholesterol, high-density lipoproteins cholesterol and low-density lipoproteins cholesterol, tryglicerides, non-esterified fatty acid, bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase, reactive oxygen metabolites, thiobarbituric acid reactive substances (TBARs), vitamin A and vitamin E were evaluated at 8 days after foaling (D0) and then at D90, D105 and D120 of lactation. In milk, the VB supplementation decreased the saturated fatty acids (P<0.05) and increased the monounsaturated fatty acids (P<0.05), and vitamins A and E (P<0.01) values. On the serum parameters, the VB supplementation decreased total cholesterol (P<0.01), tryglicerides, bilirubin, ALT and TBARs, and increased (P<0.01) vitamin E. In conclusion, the VB dietary supplementation affects the nutritional quality of donkey's milk with a benefit on the oxidative status and serum lipidic profile of the animals.

Alteration of Lipid Profile in Subclinical Hypothyroidism: A Meta-Analysis

PubMed Central

Liu, Xiao-Li; He, Shan; Zhang, Shao-Fang; Wang, Jun; Sun, Xiu-Fa; Gong, Chun-Mei; Zheng, Shi-Jie; Zhou, Ji-Chang; Xu, Jian

2014-01-01

Background Previous studies yielded controversial results about the alteration of lipid profiles in patients with subclinical hypothyroidism. We performed a meta-analysis to investigate the association between subclinical hypothyroidism and lipid profiles. Material/Methods We searched PubMed, Cochrane Library, and China National Knowledge Infrastructure articles published January 1990 through January 2014. Dissertation databases (PQDT and CDMD) were searched for additional unpublished articles. We included articles reporting the relationship between subclinical hypothyroidism and at least 1 parameter of lipid profiles, and calculated the overall weighted mean difference (WMD) with a random effects model. Meta-regression was used to explore the source of heterogeneity among studies, and the Egger test, Begg test, and the trim and fill method were used to assess potential publication bias. Results Sixteen observational studies were included in our analysis. Meta-analysis suggested that the serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and total triglyceride levels were significantly increased in patients with subclinical hypothyroidism compared with euthyroidism individuals; the WMD were 12.17 mg/dl, 7.01 mg/dl, and 13.19 mg/dl, respectively (P<0.001 for all). No significant difference was observed for serum high-density lipoprotein cholesterol (HDL-C). Match strategy was the main source of heterogeneity among studies in TC and LDL-C analysis. Potential publication bias was found in TC and LDL-C analysis by the Egger test or Begg test and was not confirmed by the trim and fill method. Conclusions Subclinical hypothyroidism may correlate with altered lipid profile. Previous studies had limitations in the control of potential confounding factors and further studies should consider those factors. PMID:25124461

Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: a randomized crossover trial.

PubMed

Larmo, Petra S; Kangas, Antti J; Soininen, Pasi; Lehtonen, Henna-Maria; Suomela, Jukka-Pekka; Yang, Baoru; Viikari, Jorma; Ala-Korpela, Mika; Kallio, Heikki P

2013-10-01

Berries are associated with health benefits. Little is known about the effect of baseline metabolome on the overall metabolic responses to berry intake. We studied the effects of berries on serum metabolome. Eighty overweight women completed this randomized crossover study. During the interventions of 30 d, subjects consumed dried sea buckthorn berries (SBs), sea buckthorn oil (SBo), sea buckthorn phenolics ethanol extract mixed with maltodextrin (SBe+MD) (1:1), or frozen bilberries. Metabolic profiles were quantified from serum samples by using (1)H nuclear magnetic resonance spectroscopy. All interventions induced a significant (P < 0.001-0.003) effect on the overall metabolic profiles. The effect was observed both in participants who had a metabolic profile that reflected higher cardiometabolic risk at baseline (group B: P = 0.001-0.008) and in participants who had a lower-risk profile (group A: P < 0.001-0.009). Although most of the changes in individual metabolites were not statistically significant after correction for multiplicity, clear trends were observed. SB-induced effects were mainly on serum triglycerides and very-low-density lipoprotein (VLDL) and its subclasses, which decreased in metabolic group B. SBo induced a decreasing trend in serum total, intermediate-density lipoprotein (IDL), and low-density lipoprotein (LDL) cholesterol and subfractions of IDL and LDL in group B. During the SBe+MD treatment, VLDL fractions and serum triglycerides increased. Bilberries caused beneficial changes in serum lipids and lipoproteins in group B, whereas the opposite was true in group A. Berry intake has overall metabolic effects, which depend on the cardiometabolic risk profile at baseline. This trial was registered at clinicaltrials.gov as NCT01860547.

Effects of sea buckthorn and bilberry on serum metabolites differ according to baseline metabolic profiles in overweight women: a randomized crossover trial1234

PubMed Central

Larmo, Petra S; Kangas, Antti J; Soininen, Pasi; Lehtonen, Henna-Maria; Suomela, Jukka-Pekka; Yang, Baoru; Viikari, Jorma; Ala-Korpela, Mika; Kallio, Heikki P

2013-01-01

Background: Berries are associated with health benefits. Little is known about the effect of baseline metabolome on the overall metabolic responses to berry intake. Objective: We studied the effects of berries on serum metabolome. Design: Eighty overweight women completed this randomized crossover study. During the interventions of 30 d, subjects consumed dried sea buckthorn berries (SBs), sea buckthorn oil (SBo), sea buckthorn phenolics ethanol extract mixed with maltodextrin (SBe+MD) (1:1), or frozen bilberries. Metabolic profiles were quantified from serum samples by using 1H nuclear magnetic resonance spectroscopy. Results: All interventions induced a significant (P < 0.001–0.003) effect on the overall metabolic profiles. The effect was observed both in participants who had a metabolic profile that reflected higher cardiometabolic risk at baseline (group B: P = 0.001–0.008) and in participants who had a lower-risk profile (group A: P < 0.001–0.009). Although most of the changes in individual metabolites were not statistically significant after correction for multiplicity, clear trends were observed. SB-induced effects were mainly on serum triglycerides and very-low-density lipoprotein (VLDL) and its subclasses, which decreased in metabolic group B. SBo induced a decreasing trend in serum total, intermediate-density lipoprotein (IDL), and low-density lipoprotein (LDL) cholesterol and subfractions of IDL and LDL in group B. During the SBe+MD treatment, VLDL fractions and serum triglycerides increased. Bilberries caused beneficial changes in serum lipids and lipoproteins in group B, whereas the opposite was true in group A. Conclusion: Berry intake has overall metabolic effects, which depend on the cardiometabolic risk profile at baseline. This trial was registered at clinicaltrials.gov as NCT01860547. PMID:23945716

Effects of Mean Flow Profiles on Instability of a Low-Density Gas Jet Injected into a High-Density Gas

NASA Technical Reports Server (NTRS)

Vedantam, Nanda Kishore

2003-01-01

The objective of this study was to investigate the effects of the mean flow profiles on the instability characteristics in the near-injector region of low-density gas jets injected into high-density ambient gas mediums. To achieve this, a linear temporal stability analysis and a spatio-temporal stability analysis of a low-density round gas jet injected vertically upwards into a high-density ambient gas were performed by assuming three different sets of mean velocity and density profiles. The flow was assumed to be isothermal and locally parallel. Viscous and diffusive effects were ignored. The mean flow parameters were represented as the sum of the mean value and a small normal-mode fluctuation. A second order differential equation governing the pressure disturbance amplitude was derived from the basic conservation equations. The first set of mean velocity and density profiles assumed were those used by Monkewitz and Sohn for investigating absolute instability in hot jets. The second set of velocity and density profiles assumed for this study were the ones used by Lawson. And the third set of mean profiles included a parabolic velocity profile and a hyperbolic tangent density profile. The effects of the inhomogeneous shear layer and the Froude number (signifying the effects of gravity) on the temporal and spatio-temporal results for each set of mean profiles were delineated. Additional information is included in the original extended abstract.

Low serum free thyroxine level is correlated with lipid profile in depressive patients with suicide attempt.

PubMed

Peng, Rui; Dai, Wen; Li, Yan

2018-05-24

The present research was carried out to observe the relationships between serum free triiothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH) levels and lipid profile and suicide risk in depressive subjects. Serum concentrations of albumin, total bilrubin, uric acid, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), high-sensitivity C-reactive protein (hs-CRP), FT3, FT4 and TSH were measured in 271 patients meeting the DSM-IV criteria for major depressive disorder (202 subjects without suicidal behavior and 69 suicide attempters). A significant decrease in serum TC, TG and FT4 levels was found in suicide attempters with major depressive disorder compared with non-suicide attempters (all p < 0.0025). For the other biochemical factors levels (albumin, total bilrubin, uric acid, HDL, LDL, hs-CRP, FT3, and TSH), there were no significant differences between suicide attempters and non-suicide attempters. Relativity analysis suggested that FT4 is positively and significantly correlated with TC (p < 0.0025); TSH is positively associated with HDL (p < 0.0025). Univariate analysis showed that serum TC and FT4 abundances are correlated with the suicide attempts in major depressive subjects. This research demonstrated that the levels of serum TC, TG, and FT4 levels in suicidal patients were greatly decreased compared with patients without suicidal behavior. These findings support the hypothesis that low serum FT4 level affects lipid profile in major depressive patients with suicidal attempt. Copyright © 2018 Elsevier B.V. All rights reserved.

Results of the IMO Video Meteor Network - April 2016

NASA Astrophysics Data System (ADS)

Molau, S.; Crivello, S.; Goncalves, R.; Saraiva, C.; Stomeo, E.; Kac, J.

2016-10-01

In 2016 April, a total of 78 video cameras of the IMO Video Meteor Network recorded more than 16 000 meteors in almost 7 700 hours of observing time. The flux density profile of the Lyrids 2016 is presented and compared to the average for the years 2011-2015. The flux density increased significantly as twilight set in on the morning of 2016 April 22. A similar increase was also seen in 2012. The population index of the Lyrids is also derived from observations around the shower maximum.

A mathematical model for predicting cyclic voltammograms of electronically conductive polypyrrole

NASA Technical Reports Server (NTRS)

Yeu, Taewhan; Nguyen, Trung V.; White, Ralph E.

1988-01-01

Polypyrrole is an attractive polymer for use as a high-energy-density secondary battery because of its potential as an inexpensive, lightweight, and noncorrosive electrode material. A mathematical model to simulate cyclic voltammograms for polypyrrole is presented. The model is for a conductive porous electrode film on a rotating disk electrode (RDE) and is used to predict the spatial and time dependence of concentration, overpotential, and stored charge profiles within a polypyrrole film. The model includes both faradic and capacitance charge components in the total current density expression.

A mathematical model for predicting cyclic voltammograms of electronically conductive polypyrrole

NASA Technical Reports Server (NTRS)

Yeu, Taewhan; Nguyen, Trung V.; White, Ralph E.

1987-01-01

Polypyrrole is an attractive polymer for use as a high-energy-density secondary battery because of its potential as an inexpensive, lightweight, and noncorrosive electrode material. A mathematical model to simulate cyclic voltammograms for polypyrrole is presented. The model is for a conductive porous electrode film on a rotating disk electrode (RDE) and is used to predict the spatial and time dependence of concentration, overpotential, and stored charge profiles within a polypyrrole film. The model includes both faradic and capacitance charge components in the total current density expression.

Goddard High Resolution Spectrograph Observations of Variability in the RS Canum Venaticorum System V711 Tauri (HR 1099)

NASA Technical Reports Server (NTRS)

Dempsey, Robert C.; Neff, James E.; Thorpe, Marjorie J.; Linsky, Jeffrey L.; Brown, Alexander; Cutispoto, Giuseppe; Rodono, Marcello

1996-01-01

Goddard High Resolution Spectrograph (GHRS) observations of the RS CVn-type binary V711 Tau (Kl IV+G5 IV) were obtained at several phases over two consecutive stellar orbital cycles in order to study ultraviolet emission-line profile and flux variability. Spectra cover the Mg II h and k lines, C IV doublet, and Si IV region, as well as the density-sensitive lines of C III] (1909 A) and Si III] (1892 A). IUE spectra, Extreme Ultra Violet (EUV) data, and Ultraviolet, Blue, Visual (UBV) photometry were obtained contemporaneously with the GHRS data. Variable extended wings were detected in the Mg II lines. We discuss the Mg II line profile variability using various Gaussian emission profile models. No rotational modulation of the line profiles was observed, but there were several large flares. These flares produced enhanced emission in the extended line wings, radial velocity shifts, and asymmetries in some line profiles. Nearly continuous flaring for more than 24 hr, as indicated in the IUE data, represents the most energetic and long-lived chromospheric and transition region flare ever observed with a total energy much greater than 5 x 10(exp 35) ergs. The C III] to Si III] line ratio is used to estimate the plasma density during the flares.

Venus mesospheric sulfur dioxide measurement retrieved from SOIR on board Venus Express

NASA Astrophysics Data System (ADS)

Mahieux, A.; Vandaele, A. C.; Robert, S.; Wilquet, V.; Drummond, R.; Chamberlain, S.; Belyaev, D.; Bertaux, J. L.

2015-08-01

SOIR on board Venus Express sounds the Venus upper atmosphere using the solar occultation technique. It detects the signature from many Venus atmosphere species, including those of SO2 and CO2. SO2 has a weak absorption structure at 4 μm, from which number density profiles are regularly inferred. SO2 volume mixing ratios (VMR) are calculated from the total number density that are also derived from the SOIR measurements. This work is an update of the previous work by Belyaev et al. (2012), considering the SO2 profiles on a broader altitude range, from 65 to 85 km. Positive detection VMR profiles are presented. In 68% of the occultation spectral datasets, SO2 is detected. The SO2 VMR profiles show a large variability up to two orders of magnitude, on a short term time scales. We present mean VMR profiles for various bins of latitudes, and study the latitudinal variations; the mean latitude variations are much smaller than the short term temporal variations. A permanent minimum showing a weak latitudinal structure is observed. Long term temporal trends are also considered and discussed. The trend observed by Marcq et al. (2013) is not observed in this dataset. Our results are compared to literature data and generally show a good agreement.

Core Radial Electric Field and Transport in Wendelstein 7-X Plasmas

NASA Astrophysics Data System (ADS)

Pablant, Novimir

2016-10-01

Results from the investigation of core transport and the role of the radial electric field profile (Er) in the first operational phase of the Wendelstein 7-X (W7-X) stellarator are presented. In stellarator plasmas, the details of the Er profile are expected to have a strong effect on both the particle and heat fluxes. Neoclassical particle fluxes are not intrinsically ambipolar, which leads to the formation of a radial electric field that enforces ambipolarity. The radial electric field is closely related to the perpendicular plasma flow (u⊥) through the force balance equation. This allows the radial electric field to be inferred from measurements of the perpendicular flow velocity from the x-ray imaging crystal spectrometer (XICS) and correlation reflectometry diagnostics. Large changes in the perpendicular rotation, on the order of Δu⊥ 5km /s (ΔEr 12kV / m), have been observed within a set of experiments where the heating power was stepped down from 2 MW to 0.6 MW . These experiments are examined in detail to explore the relationship between, heating power, response of the temperature and density profiles and the response of the radial electric field. Estimations of the core transport are based on power balance and utilize electron temperature (Te) profiles from the ECE and Thomson scattering, electron density profiles (ne) from interferometry and Thomson scattering, ion temperature (Ti) profiles from XICS, along with measurements of the total stored energy and radiated power. Also described are a set core impurity confinement experiments and results. Impurity confinement has been investigated through the injection of trace amount of argon impurity gas at the plasma edge in conjunction with measurements of the density of various ionization states of argon from the XICS and High Efficiency eXtreme-UV Overview Spectrometer (HEXOS) diagnostics. Finally the inferred Er and heat flux profiles are compared to initial neoclassical calculations using measured plasma profiles. On behalf of the W7-X Team.

Correlation of ion and beam current densities in Kaufman thrusters.

NASA Technical Reports Server (NTRS)

Wilbur, P. J.

1973-01-01

In the absence of direct impingement erosion, electrostatic thruster accelerator grid lifetime is defined by the charge exchange erosion that occurs at peak values of the ion beam current density. In order to maximize the thrust from an engine with a specified grid lifetime, the ion beam current density profile should therefore be as flat as possible. Knauer (1970) has suggested this can be achieved by establishing a radial plasma uniformity within the thruster discharge chamber; his tests with the radial field thruster provide an example of uniform plasma properties within the chamber and a flat ion beam profile occurring together. It is shown that, in particular, the ion density profile within the chamber determines the beam current density profile, and that a uniform ion density profile at the screen grid end of the discharge chamber should lead to a flat beam current density profile.

Waist circumference: a better index of fat location than WHR for predicting lipid profile in overweight/obese Iranian women.

PubMed

Shahraki, T; Shahraki, M; Roudbari, M

2009-01-01

We carried out a clinical cross-sectional study on 728 overweight and obese women aged 20-60 years during July 2005-May 2006 in Sistan and Baluchestan, Islamic Republic of Iran. Body mass index (BMI) and waist circumference (WC) showed significant correlation with total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol. After adjustment for age and BMI, this was also true for WC with TC and TG. There was no such correlation between waist-to-hip ratio (WHR) and lipid profile. Hence, WC was a better anthropometric index of fat location than WHR to estimate lipid profile in overweight and obese adult women.

Total cardiovascular risk profile of Taiwanese vegetarians.

PubMed

Chen, C-W; Lin, Y-L; Lin, T-K; Lin, C-T; Chen, B-C; Lin, C-L

2008-01-01

Although the health benefits of vegetarian diets have been well documented among Western population, there are geographic differences of vegetarian diets and the health benefits of the Taiwanese vegetarian diet have not been studied extensively. In addition to conventional risk factors, homocysteine and high-sensitivity C-reactive protein (hs-CRP) levels have been found to predict first atherothrombotic events. We undertook this study to examine the total risk profile of Taiwanese vegetarians. A total of 198 healthy subjects (99 vegetarians and 99 omnivores) were recruited. Fasting blood samples were analyzed for glucose, cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), white blood cell count, hs-CRP and homocysteine. There was no significant difference in age, body mass index, blood glucose, white blood cell count, triglyceride and HDL-C between the two groups. The vegetarian group had significantly more females (65.7 vs 46.5%); lower body weight (58.66+/-11.13 vs 62.88+/-12.24 kg); shorter height (159.14+/-7.88 vs 162.53 +/-8.14 cm); lower total cholesterol (184.74+/-33.23 vs 202.01+/-41.05 mg/dl); and lower LDL-C (119.63+/-31.59 vs 135.89+/-39.50 mg/dl). Hs-CRP was significantly lower (0.14+/-0.23 vs 0.23+/-0.44 mg/dl, P=0.025), whereas homocysteine was significantly higher (10.97+/-6.69 vs 8.44+/-2.50 micromol/l, P=0.001) in vegetarians than omnivores. Taiwanese vegetarians have lower total cholesterol, LDL-C and hs-CRP levels, and higher homocysteine levels than omnivores. Owing to different predictive value of each risk factor, the Taiwanese vegetarians had a better cardiovascular risk profile than omnivores. Whether the Taiwanese vegetarian diet should be supplemented with vitamin B(12) to lower serum homocysteine level remains to be addressed.

Clinical and Biochemical Profiles according to Homeostasis Model Assessment-insulin Resistance (HOMA-IR) in Korean Women with Polycystic Ovary Syndrome.

PubMed

Lee, Da Eun; Park, Soo Yeon; Park, So Yun; Lee, Sa Ra; Chung, Hye Won; Jeong, Kyungah

2014-12-01

The aim of this study was to investigate the clinical and biochemical profiles according to homeostasis model assessment of insulin resistance (HOMA-IR) in Korean polycystic ovary syndrome (PCOS) patients. In 458 PCOS patients diagnosed by the Rotterdam European Society for Human Reproduction and Embryology (ESHRE) criteria, measurements of somatometry, blood test of hormones, glucose metabolic and lipid profiles, and transvaginal or transrectal ultrasonogram were carried out. HOMA-IR was then calculated and compared with the clinical and biochemical profiles related to PCOS. The patients were divided into 4 groups by quartiles of HOMA-IR. The mean level of HOMA-IR was 2.18 ± 1.73. Among the four groups separated according to HOMA-IR, body weight, body mass index (BMI), waist-to-hip ratio (WHR), triglyceride (TG), total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, lipid accumulation product (LAP) index, high-sensitivity C-reactive protein (hs-CRP), Apoprotein B, free testosterone, and sex hormone binding globulin (SHBG) were found to be significantly different. TG, LAP index, glucose metabolic profiles, and hs-CRP were positively correlated with HOMA-IR after adjustment for BMI. Our results suggest that the clinical and biochemical profiles which are applicable as cardiovascular risk factors are highly correlated with HOMA-IR in Korean women with PCOS.

Adiponectin and markers of metabolic syndrome in obese children and adolescents: impact of 8-mo regular physical exercise program.

PubMed

Nascimento, Henrique; Costa, Elísio; Rocha, Susana; Lucena, Clarice; Rocha-Pereira, Petronila; Rêgo, Carla; Mansilha, Helena Ferreira; Quintanilha, Alexandre; Aires, Luísa; Mota, Jorge; Santos-Silva, Alice; Belo, Luís

2014-08-01

Adiponectin circulates as low-, medium-, and high-molecular-weight multimers (LMW, MMW, and HMW) and influences lipid profile and insulin resistance (IR), HMW being considered as the most biologically active form. We aimed to study the relation between adiponectin and markers of metabolic syndrome (MS) in pediatric obesity, and the impact of physical exercise. The study consisted of a cross-sectional part and an 8-mo physical exercise program. Lipid profile, insulin, glucose, C-reactive protein (CRP), total adiponectin (TA), and homeostasis model assessment IR (HOMA-IR) were measured. Adiponectin multimers were studied in a prepubertal group. Obesity is associated with increased dyslipidemia, IR, and inflammation. TA is correlated inversely with adiposity, triglycerides, HOMA-IR, and CRP, and positively with high-density lipoprotein cholesterol (HDLc)/total cholesterol (TC) ratio. HMW mimicked TA associations. The intervention program led to a reduction of TC, low-density lipoprotein cholesterol (LDLc), insulin, HOMA-IR, and trunk percentage of fat, and an increase of HDLc/TC ratio, in the obese group. BMI improvements prevented adiponectin reduction and correlated with increments in HMW and MMW. Obesity-related increase in MS features might be linked to lower adiponectin. HMW and MMW were the multimers that most explained the MS features. The intervention program improved the lipid profile and IR, and prevented the reduction of adiponectin.

Changes in profile of lipids and adipokines in patients with newly diagnosed hypothyroidism and hyperthyroidism

PubMed Central

Chen, Yanyan; Wu, Xiafang; Wu, Ruirui; Sun, Xiance; Yang, Boyi; Wang, Yi; Xu, Yuanyuan

2016-01-01

Changes in profile of lipids and adipokines have been reported in patients with thyroid dysfunction. But the evidence is controversial. The present study aimed to explore the relationships between thyroid function and the profile of lipids and adipokines. A cross-sectional study was conducted in 197 newly diagnosed hypothyroid patients, 230 newly diagnosed hyperthyroid patients and 355 control subjects. Hypothyroid patients presented with significantly higher serum levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDLC), fasting insulin, resistin and leptin than control (p < 0.05). Hyperthyroid patients presented with significantly lower serum levels of high-density lipoprotein cholesterol, LDLC and leptin, as well as higher levels of fasting insulin, resistin, adiponectin and homeostasis model insulin resistance index (HOMA-IR) than control (p < 0.05). Nonlinear regression and multivariable linear regression models all showed significant associations of resistin or adiponectin with free thyroxine and association of leptin with thyroid-stimulating hormone (p < 0.001). Furthermore, significant correlation between resistin and HOMA-IR was observed in the patients (p < 0.001). Thus, thyroid dysfunction affects the profile of lipids and adipokines. Resistin may serve as a link between thyroid dysfunction and insulin resistance. PMID:27193069

Internal dark matter structure of the most massive galaxy clusters

NASA Astrophysics Data System (ADS)

Le Brun, A. M. C.; Arnaud, M.; Pratt, G. W.; Teyssier, R.

2018-01-01

We investigate the evolution of the dark matter density profiles of the most massive galaxy clusters in the Universe. Using a `zoom-in' procedure on a large suite of cosmological simulations of total comoving volume of 3 (h - 1 Gpc)3, we study the 25 most massive clusters in four redshift slices from z ˜ 1 to the present. The minimum mass is M500 > 5.5 × 1014 M⊙ at z = 1. Each system has more than two million particles within r500. Once scaled to the critical density at each redshift, the dark matter profiles within r500 are strikingly similar from z ˜ 1 to the present day, exhibiting a low dispersion of 0.15 dex, and showing little evolution with redshift in the radial logarithmic slope and scatter. They have the running power-law shape typical of the Navarro-Frenk-White type profiles, and their inner structure, resolved to 3.8 h-1 comoving kpc at z = 1, shows no signs of converging to an asymptotic slope. Our results suggest that this type of profile is already in place at z > 1 in the highest-mass haloes in the Universe, and that it remains exceptionally robust to merging activity.

TEC data ingestion into IRI and NeQuick over the antarctic region

NASA Astrophysics Data System (ADS)

Nava, Bruno; Pezzopane, Michael; Radicella, Sandro M.; Scotto, Carlo; Pietrella, Marco; Migoya Orue, Yenca; Alazo Cuartas, Katy; Kashcheyev, Anton

2016-07-01

In the present work a comparative analysis to evaluate the IRI and NeQuick 2 models capabilities in reproducing the ionospheric behaviour over the Antarctic Region has been performed. A technique to adapt the two models to GNSS-derived vertical Total Electron Content (TEC) has been therefore implemented to retrieve the 3-D ionosphere electron density at specific locations where ionosonde data were available. In particular, the electron density profiles used in this study have been provided in the framework of the AUSPICIO (AUtomatic Scaling of Polar Ionograms and Cooperative Ionospheric Observations) project applying the Adaptive Ionospheric Profiler (AIP) to ionograms recorded at eight selected mid, high-latitude and polar ionosondes. The relevant GNSS-derived vertical TEC values have been obtained from the Global Ionosphere Maps (GIM) produced by the Center for Orbit Determination in Europe (CODE). The effectiveness of the IRI and NeQuick 2 in reconstructing the ionosphere electron density at the given locations and epochs has been primarily assessed in terms of statistical comparison between experimental and model-retrieved peak parameters values (foF2 and hmF2). The analysis results indicate that in general the models are equivalent in their ability to reproduce the critical frequency of the F2 layer and they also tend to overestimate the height of the peak electron density, especially during high solar activity periods. Nevertheless this tendency is more noticeable in NeQuick 2 than in IRI. For completeness, the statistics indicating the models bottomside reconstruction capabilities, computed as height integrated electron density profile mismodeling, will also be discussed.

Comparison of COSMIC RO Data with European Digisondes and GPS TEC measurements

NASA Astrophysics Data System (ADS)

Zakharenkova, Irina; Krypiak-Gregorczyk, Anna; Shagimuratov, Irk; Krankowski, Andrzej; Lagovsky, Anatoly

FormoSat-3/COSMIC now provides unprecedented global coverage of GPS occultations mea-surements, each of which yields the ionosphere electron density information with high vertical resolution. However systematic validation work is still needed before using the powerful RO technique for sounding the ionosphere on a routine basis. In the given study electron density profiles retrieved from the Formosat-3/COSMIC RO measurements were compared with differ-ent kinds of ground-based observations. We used the ionospheric data recorded by European digisondes of DIAS network (Rome, Ebro, Arenosillo, Athens, Chilton, Pruhonice and Julius-ruh) for temporal interval of 2007-2009 and compare these ground measured data with the GPS COSMIC RO ionospheric profiles. It was revealed that in general the form of COSMIC profile in the bottom side is in a good agreement with ionosonde profiles, the heights of the peak density value are also good comparable. Special attention was focused to the question of the topside part of electron density profile. Practically for all analyzed cases there are observed the understated values of electron density in the topside part of the ionosonde profiles in compare with RO profiles. As the topside ionosonde profile is obtained by fitting a model to the peak electron density value, the COSMIC radio occultation measurements can make an important contribution to the investigation of the topside part of the ionosphere. In order to assess the ac-curacy of the COSMIC ionospheric electron density retrievals, coincidences of ionosonde data with COSMIC NmF2 values have been examined. NmF2 was calculated from the observed critical plasma frequency foF2 of the F2 layer. Values of foF2 have been scaled manually from ionograms for all considered time-location cases to avoid the evident risks related with using of the autoscaled data. The created scatter plots show a high degree of correlation between two independent estimates of NmF2. Also it was analyzed the variation of NmF2 for the considered seasons depending on day-time and night-time conditions. Also it was analyzed the total elec-tron content values calculated for the nearest ground-based GPS stations located in European region. To compare GPS TEC with RO and ionosondes' data these profiles were integrated. In general bottom parts of COSMIC and ionosondes' data are in a rather good agreement while the topside can be varied greatly that is the evidence of difference in the topside parts of these profiles. GPS TEC values are greater than COSMIC and ionosondes' data as TEC contains IEC and PEC. This procedure can be useful to estimate the impact of PEC into TEC. Results of the given comparisons can be important to validate the reliability of the COSMIC iono-spheric observations using the RO technique. We acknowledge the Taiwan's National Space Organization (NSPO) and the University Corporation for Atmospheric Research (UCAR) for providing the COSMIC Data. We are grateful to European Digital Upper Atmosphere Server (DIAS) for providing the ionosondes' products and to International GNSS Service (IGS) for GPS Data.

Changes in HDL-c concentrations after 16 weeks of combined training in postmenopausal women: characteristics of positive and negative responders.

PubMed

Diniz, Tiego A; Rossi, Fabricio E; Fortaleza, Ana Claudia Souza; Neves, Lucas Melo; Christofaro, Diego Giulliano Destro; Buonani, Camila; Lira, Fabio S; Campos, Eduardo Zapaterra; Prado, Wagner Luiz do; Freitas, Ismael Forte

2018-01-01

This study aimed to investigate the individual characteristics of body composition and metabolic profile that could explain interindividual variation in high-density lipoprotein cholesterol (HDL-c) concentrations in response to 16 weeks of combined strength plus aerobic (combined) training in postmenopausal women. The participants were divided into tertiles based on percentage of changes in HDL-c concentrations after combined training. Only women in the upper tertile (positive responders: Δ > 10.4%; n = 19) and lower tertile (negative responders: Δ < -1.4%; n = 19) were considered for analyses. The total body fat (BF), trunk fat (TF), android fat (AF), gynoid fat, and lean body mass were estimated by dual-energy X-ray absorptiometry. The metabolic profile - glucose, triacylglycerol, total cholesterol, HDL-c, low-density lipoprotein cholesterol, and very-low-density lipoprotein (VLDL) - were assessed. After 16 weeks, both positive and negative responders presented similar improvement in body composition, such as a decrease in percentage and kilograms of BF, TF, and AF, and increase in lean body mass (p value for time < 0.05). As expected, there was an effect of time and also a significant interaction (time vs. group) (p value < 0.001) in the improvement of HDL-c, with higher values for positive responders. Regarding metabolic profile, there were significant interactions (time vs. group) for triacylglycerol (p value = 0.032) and VLDL (p value = 0.027) concentrations, with lower values for positive responders. Our results suggests there is heterogeneity in combined training-induced HDL-c changes in postmenopausal women, and the positive responders were those who presented more pronounced decreases in triacylglycerol and VLDL concentrations.

[Number of teeth and hormonal profile of postmenopausal women with osteoporosis, osteopenia and normal bone mineral density--a preliminary study].

PubMed

Stagraczyński, Maciej; Kulczyk, Tomasz; Leszczyński, Piotr; Męczekalski, Błażej

2015-10-01

Profound hypoestrogenism causes increased risk of osteoporosis and bone fracture in menopause. This period of women life is also characterized by decrease number of teeth and deterioration of oral cavity health. The aim of the study was to assess the number of teeth, hormonal profile (Follicle-stimualting hormone (FSH), estradiol (E2), testosterone (T) and dehydroepiandrosterone sulphate (DHEA-S) and the bone mineral density (BMD) of the lumbar part of the spine in postmenopausal women with osteoporosis, osteopenia and normal BMD. The next step of the study was to determine whether there was a correlation between vertebral mineral bone density, the hormonal profile and the number of teeth. A total number of 47 women was involved in the study. Based on the results of densitometry tests (DEXA) of vertebral column the subjects were divided into 3 groups: 10 with osteoporosis, 20 with osteopenia and 17 with normal BMD. All the subjects had undergone a hormonal assessment which included blood serum estimation for FSH, E2, DHEA-S and T levels. Also the total number of teeth present was recorded. Serum estradiol and testosterone levels in postmenopausal women were found to be positively correlated with the number of teeth present. A negative correlation was found between age and the number of maxillary teeth in postmenopausal women with osteopenia. There was no influence of serum FSH, estradiol, testosterone and DHEA-S levels on vertebral BMD loss in postmenopausal women. There was no correlation between teeth number and BMD of vertebral column. Serum levels of estradiol and testosterone in postmenopausal women positively correlate with teeth numbers. Age is the main risk factor for teeth loss in postmenopausal women. © 2015 MEDPRESS.

Rat pancreatic B-cells after chronic alcohol feeding. A morphometric and fine structural study.

PubMed

Koko, V; Todorović, V; Nikolić, J A; Glisić, R; Cakić, M; Lacković, V; Petronijević, L; Stojković, M; Varagić, J; Janić, B

1995-04-01

Quantitative analysis of the light microscopic and fine structure of rat islet B-cells was carried out in chronic alcoholism. Absolute pancreatic weight and volume were similar in groups C (control) and E (ethanol), but relative pancreatic weight in group E rat was decreased. The results for fasting blood glucose and insulin levels were similar in the two groups of animals. There was a significantly reduced total pancreatic islet volume in E rats. The total number of endocrine cells both per islet and per microns2 of islet was similar in the two groups of animals. The volume density and number of B-cells per islet and per microns2 of islet were not changed in ethanol-treated rats as compared with the control. On the other hand, diameter, surface area and volume of the B-cells and their nuclei were found to be statistically significantly decreased. Histological examination revealed that islet blood vessels were dilated in alcoholic rats. Over the 4-month period of ethanol intake a significant decrease in cell profile area, nuclear profile area and volume density of cytoplasmic granules and an increase in the profile area and volume density of endoplasmic reticulum occurred. The gross histological alteration seen in most B-cells of the ethanol-treated rats was irregularity of the nuclear envelope with deep invagination and with margination of heterochromatin and many empty granules or granules without clear electron dense crystals of insulin. The present results indicate some optical and structural abnormalities of B-cells in chronic alcoholism that may be related to cell dysfunction and may contribute, at least in part, to the endocrine pancreas functional disturbance.

Effects of ultrasound energy density on the non-thermal pasteurization of chocolate milk beverage.

PubMed

Monteiro, Sara H M C; Silva, Eric Keven; Alvarenga, Verônica O; Moraes, Jeremias; Freitas, Mônica Q; Silva, Márcia C; Raices, Renata S L; Sant'Ana, Anderson S; Meireles, M Angela A; Cruz, Adriano G

2018-04-01

This study presents the emerging high-intensity ultrasound (HIUS) processing as a non-thermal alternative to high-temperature short-time pasteurization (HTST). Chocolate milk beverage (CMB) was subjected to different ultrasound energy densities (0.3-3.0 kJ/cm 3 ), as compared to HTST pasteurization (72 °C/15 s) aimed to verify the effect of the HIUS processing on the microbiological and physicochemical characteristics of the beverage. The application of HIUS at an energy density of 3.0 kJ/cm 3 was able to reduce 3.56 ± 0.02 logarithmic cycles in the total aerobic counts. In addition, the ultrasound energy density affected the physical properties of the beverage as the size distribution of fat globule and rheological behavior, as well as the chemical properties such as antioxidant activity, ACE inhibitory activity, fatty acid profile, and volatile profile. In general, the different energetic densities used as a non-thermal method of pasteurization of CMB were more effective when compared to the conventional pasteurization by HTST, since they improved the microbiological and physicochemical quality, besides preserving the bioactive compounds and the nutritional quality of the product. Copyright © 2017 Elsevier B.V. All rights reserved.

Electronic properties of RDX and HMX: Compton scattering experiment and first-principles calculation.

PubMed

Ahuja, B L; Jain, Pradeep; Sahariya, Jagrati; Heda, N L; Soni, Pramod

2013-07-11

The first-ever electron momentum density (EMD) measurements of explosive materials, namely, RDX (1,3,5-trinitro-1,3,5-triazacyclohexane, (CH2-N-NO2)3) and HMX (1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane, (CH2-N-NO2)4), have been reported using a 740 GBq (137)Cs Compton spectrometer. Experimental Compton profiles (CPs) are compared with the EMDs derived from linear combination of atomic orbitals with density functional theory. It is found that the CPs deduced from generalized gradient approximation (GGA) with Wu-Cohen exchange energies give a better agreement with the corresponding experimental profiles than those from local density approximation and other schemes of GGA. Further, Mulliken population, energy bands, partial and total density of states, and band gap have also been reported using GGA calculations. Present ground state calculations unambiguously show large band gap semiconductor nature of both RDX and HMX. A similar type of bonding in these materials is uniquely established using Compton data and density of states. It is also outstandingly consistent with the Mulliken population, which predicts almost equal amount of charge transfer (0.84 and 0.83 e(-)) from H1 + H2 + N2 to C1 + N1 + O1 + O2 in both the explosives.

Ionospheric Profiling Through Nonlinear Dielectric Response to Electron Density*

NASA Astrophysics Data System (ADS)

Moses, R. W.; Jacobson, A. R.

2002-12-01

It is well known that the total electron content (TEC) along a line of sight in the ionosphere can be extracted from the frequency-dependent time lag measured in transionospheric RF signals [1]. For five years the FORTE satellite has been used to develop a substantial data base of transionospheric signals originating in both lightning and man-made sources. Here, we use signals generated by the Los Alamos Portable Pulser (LAPP) [2] and recorded by FORTE as input to a multi-layer computer model of RF wave propagation in the ionosphere, including Faraday rotation in the Earth's magnetic field. Nonlinearities in both the frequency dependence of the group velocity and the optical pathlength are modeled and matched to FORTE data to infer details of the vertical profile of electron density. Using the International Reference Ionosphere [3] as a profile model, we show how the vertical TEC, peak electron density, and ionospheric thickness can be extracted even at large transmitter-to-satellite separations. [1] Roussel-Dupre, R. A., A. R. Jacobson, and L. A. Triplett, Radio Sci., 36, 1615 (2001). [2] Massey, R.S., S.O. Knox, R.C. Franz, D.N. Holden, and C.T. Rhodes, Radio Sci., 33, 1739 (1998). [3] Bilitza, D., "International Reference Ionosphere 1990," NSSDC/WDC-A-R&S 90-92. *Work supported by USDOE

The virialization density of peaks with general density profiles under spherical collapse

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rubin, Douglas; Loeb, Abraham, E-mail: dsrubin@physics.harvard.edu, E-mail: aloeb@cfa.harvard.edu

2013-12-01

We calculate the non-linear virialization density, Δ{sub c}, of halos under spherical collapse from peaks with an arbitrary initial and final density profile. This is in contrast to the standard calculation of Δ{sub c} which assumes top-hat profiles. Given our formalism, the non-linear halo density can be calculated once the shape of the initial peak's density profile and the shape of the virialized halo's profile are provided. We solve for Δ{sub c} for halos in an Einstein de-Sitter and a ΛCDM universe. As examples, we consider power-law initial profiles as well as spherically averaged peak profiles calculated from the statisticsmore » of a Gaussian random field. We find that, depending on the profiles used, Δ{sub c} is smaller by a factor of a few to as much as a factor of 10 as compared to the density given by the standard calculation ( ≈ 200). Using our results, we show that, for halo finding algorithms that identify halos through an over-density threshold, the halo mass function measured from cosmological simulations can be enhanced at all halo masses by a factor of a few. This difference could be important when using numerical simulations to assess the validity of analytic models of the halo mass function.« less

Double-cavity radiometer for high-flux density solar radiation measurements.

PubMed

Parretta, A; Antonini, A; Armani, M; Nenna, G; Flaminio, G; Pellegrino, M

2007-04-20

A radiometric method has been developed, suitable for both total power and flux density profile measurement of concentrated solar radiation. The high-flux density radiation is collected by a first optical cavity, integrated, and driven to a second optical cavity, where, attenuated, it is measured by a conventional radiometer operating under a stationary irradiation regime. The attenuation factor is regulated by properly selecting the aperture areas in the two cavities. The radiometer has been calibrated by a pulsed solar simulator at concentration levels of hundreds of suns. An optical model and a ray-tracing study have also been developed and validated, by which the potentialities of the radiometer have been largely explored.

Effects of Mean Flow Profiles on the Instability of a Low-Density Gas Jet Injected into a High-Density Gas

NASA Technical Reports Server (NTRS)

Vedantam, NandaKishore; Parthasarathy, Ramkumar N.

2004-01-01

The effects of the mean velocity profiles on the instability characteristics in the near-injector region of axisymmetric low density gas jets injected vertically upwards into a high-density gas medium were investigated using linear inviscid stability analysis. The flow was assumed to be isothermal and locally parallel. Three velocity profiles, signifying different changes in the mean velocity in the shear layer, were used in the analysis. The effects of the inhomogeneous shear layer and the Froude number (signifying the effects of gravity) on the instability for each set of mean profiles were delineated. At a large Froude number (negligible gravity), a critical density ratio was found for the three profiles at which the jet became absolutely unstable. The critical density ratio for each velocity profile was increased as the Froude number was reduced. A critical Froude number was found for the three sets of profiles, below which the jet was absolutely unstable for all the density ratios less than unity, which demarcated the jet flow into the momentum-driven regime and the buoyancy-driven regime.

L-Carnitine supplementation improved clinical status without changing oxidative stress and lipid profile in women with knee osteoarthritis.

PubMed

Malek Mahdavi, Aida; Mahdavi, Reza; Kolahi, Sousan; Zemestani, Maryam; Vatankhah, Amir-Mansour

2015-08-01

Considering the pathologic importance of oxidative stress and altered lipid metabolism in osteoarthritis (OA), this study aimed to investigate the effect of l-carnitine supplementation on oxidative stress, lipid profile, and clinical status in women with knee OA. We hypothesized that l-carnitine would improve clinical status by modulating serum oxidative stress and lipid profile. In this randomized double-blind, placebo-controlled trial, 72 overweight or obese women with mild to moderate knee OA were randomly allocated into 2 groups to receive 750 mg/d l-carnitine or placebo for 8 weeks. Dietary intake was evaluated using 24-hour recall for 3 days. Serum malondialdehyde (MDA), total antioxidant capacity (TAC) and lipid profile, visual analog scale for pain intensity, and patient global assessment of severity of disease were assessed before and after supplementation. Only 69 patients (33 in the l-carnitine group and 36 in the placebo group) completed the study. l-Carnitine supplementation resulted in significant reductions in serum MDA (2.46 ± 1.13 vs 2.16 ± 0.94 nmol/mL), total cholesterol (216.09 ± 34.54 vs 206.12 ± 39.74 mg/dL), and low-density lipoprotein cholesterol (129.45 ± 28.69 vs 122.05 ± 32.76 mg/dL) levels compared with baseline (P < .05), whereas these parameters increased in the placebo group. Serum triglyceride, high-density lipoprotein cholesterol, and TAC levels did not change significantly in both groups (P > .05). No significant differences were observed in dietary intake, serum lipid profile, MDA, and TAC levels between groups after adjusting for baseline values and covariates (P > .05). There were significant intragroup and intergroup differences in pain intensity and patient global assessment of disease status after supplementation (P < .05). Collectively, l-carnitine improved clinical status without changing oxidative stress and lipid profile significantly in women with knee OA. Copyright © 2015 Elsevier Inc. All rights reserved.

The Association of Bread and Rice with Metabolic Factors in Type 2 Diabetic Patients.

PubMed

Akhoundan, Mahdieh; Shadman, Zhaleh; Jandaghi, Parisa; Aboeerad, Maryam; Larijani, Bagher; Jamshidi, Zahra; Ardalani, Hamidreza; Khoshniat Nikoo, Mohsen

2016-01-01

Carbohydrates are shown to have an important role in blood glucose control, type 2 diabetes and cardiovascular diseases risk. This is even more challenging when considering populations consuming refined grains diets. Bread and rice are staple foods which supply main proportion of Iranian calorie intake. This study was designed to investigate the effect of bread and rice intake on blood glucose control, lipid profile and anthropometric measurements in Iranian type 2 diabetic patients. 426 patients with type 2 diabetes were included in this study. Anthropometric measurements were done using standard methods. Dietary information was assessed by a valid and reliable food frequency questionnaire (FFQ). Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), serum triglycride (TG), total cholesterol (TC), low density lipoprotein (LDL) and high density lipoprotein (HDL) cholesterol were examined after 12-hour fasting. The results represented that people in the highest tertile compared to the lowest tertile of calorie adjusted total bread intake have higher FBG. FBG in the highest tertile of calorie adjusted total bread-rice intake was also significantly higher than the lowest. The association remained significant after adjusting for potential confounders. Rice intake showed no association with cardio-metabolic risk factors. We founded that higher total bread intake and total bread-rice intake were associated with FBG in type 2 diabetic patients whereas rice intake was not associated with glucose and lipid profile. This result should be confirmed in prospective studies, considering varieties, glycemic index (GI), glycemic load (GL) and cooking method of bread and rice.

Empirical analysis of electromagnetic profiles for groundwater prospecting in rural areas of Ibadan, southwestern Nigeria

NASA Astrophysics Data System (ADS)

Ehinola, O. A.; Opoola, A. O.; Adesokan, H. A.

2006-04-01

The Slingram electromagnetic (EM) survey using a coil separation of 60 and 100 m was carried out in ten villages in the Akinyele area of Ibadan, southwestern Nigeria to aid in the development of groundwater. Five main rock types including an undifferentiated gneiss complex (Su), biotite-garnet schist/gneiss (Bs), quartzite and quartz schist (Q), migmatized undifferentiated biotite/hornblende gneiss (M) and pegmatite/quartz vein (P) underlie the study area. A total of 31 EM profiles was made to accurately locate prospective borehole sites in the field. Four main groups with different behavioural patterns were categorized from the EM profiles. Group 1 is characterized by a high density of positive (HDP) or a high density of negative (HDN) real and imaginary curves, Group 2 by parallel real and imaginary curves intersecting with negligible amplitude (PNA), Group 3 by frequent intersection of a high density of negative minima (FHN) real and imaginary curves, and Group 4 by separate and approximately parallel (SAP) real and imaginary curves. Qualitative pictures of the overburden thickness and the extent of fracturing have been proposed from these behavioural patterns. A comparison of the borehole yield with the overburden thickness and the level of fracturing shows that the borehole yield depends more on the fracture density than on the overburden thickness. The asymmetry of the anomaly was also found to be useful in the determination of the inclination of the conductor/fracture.

A drop in the pond: the effect of rapid mass-loss on the dynamics and interaction rate of collisionless particles

NASA Astrophysics Data System (ADS)

Penoyre, Zephyr; Haiman, Zoltán

2018-01-01

In symmetric gravitating systems experiencing rapid mass-loss, particle orbits change almost instantaneously, which can lead to the development of a sharply contoured density profile, including singular caustics for collisionless systems. This framework can be used to model a variety of dynamical systems, such as accretion discs following a massive black hole merger and dwarf galaxies following violent early star formation feedback. Particle interactions in the high-density peaks seem a promising source of observable signatures of these mass-loss events (i.e. a possible EM counterpart for black hole mergers or strong gamma-ray emission from dark matter annihilation around young galaxies), because the interaction rate depends on the square of the density. We study post-mass-loss density profiles, both analytic and numerical, in idealized cases and present arguments and methods to extend to any general system. An analytic derivation is presented for particles on Keplerian orbits responding to a drop in the central mass. We argue that this case, with initially circular orbits, gives the most sharply contoured profile possible. We find that despite the presence of a set of singular caustics, the total particle interaction rate is reduced compared to the unperturbed system; this is a result of the overall expansion of the system dominating over the steep caustics. Finally, we argue that this result holds more generally, and the loss of central mass decreases the particle interaction rate in any physical system.

Scaling of confinement and profiles in the EXTRAP T2 reversed-field pinch

NASA Astrophysics Data System (ADS)

Welander, A.

1999-01-01

In the EXTRAP T2 reversed-field pinch the diagnostic techniques for the measurement of electron density and temperature include; Thomson scattering which gives values at three radial positions in the core (r/a = 0, 0.28, 0.56), Langmuir probes which give values at the edge (r/a > 0.9) and interferometry which gives a line-averaged density. The empirical scaling of electron density and temperature including profile information with global plasma parameters has been studied. The density profile is subject to large variations, with an average parabolic shape when the density is low and flatter shapes when the density is increased. The change in the profile shape can be attributed to a shift in the penetration length of neutrals from the vicinity of the wall. The temperature scales roughly as I/n1/2 where I is the plasma current and n is the density. The temperature profile is always quite flat with lower variations and there is a tendency for a flatter profile at higher temperatures.

Evaluation of lipid profile in adolescents during long-term use of combined oral hormonal contraceptives.

PubMed

Guazzelli, Christina Aparecida Falbo; Lindsey, Prescilla Chow; de Araújo, Fabio Fernando; Barbieri, Márcia; Petta, Carlos Alberto; Aldrighi, Jose Mendes

2005-02-01

The study evaluated the effects of the long-term use of a combined oral hormonal contraceptive containing 30 microg ethinyl estradiol and 75 microg gestodene in adolescents. Thirty-three volunteers, aged from 14 to 19 years, who used the oral contraceptive for three consecutive years, were studied. Evaluation of total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides was made before use and after 1, 2 and 3 years. During the 3-year study period, total cholesterol, HDL-C, LDL-C and triglyceride levels were significantly higher than previous measurements, but average values did not exceed the normal range. Compared to the first year, the second- and third-year cholesterol, HDL-C, LDL-C and triglyceride levels were not significantly different.

Effects of low-dose monophasic levonorgestrel with ethinyl estradiol preparation on serum lipid levels: A twenty-four month clinical trial.

PubMed

Young, R L; DelConte, A

1999-11-01

The aim of this 24-cycle study was to evaluate the effects on serum lipid concentrations of an oral contraceptive preparation containing 100 microg levonorgestrel and 20 microg ethinyl estradiol. Forty-two healthy women were enrolled in a study designed to evaluate the effects on serum lipid concentrations of an oral contraceptive containing 100 microg levonorgestrel and 20 microg ethinyl estradiol. Lipid data were evaluated for 28 women who completed 24 cycles of treatment with a preparation of 100 microg levonorgestrel with 20 microg ethinyl estradiol for 21 days followed by placebo for 7 days. Concentrations of triglycerides, total cholesterol, high-density lipoprotein cholesterol, high-density lipoprotein cholesterol subfractions 2 and 3, low-density lipoprotein cholesterol, and apolipoproteins A-I and B were analyzed. Mean percentage changes from baseline were tested for significance by means of paired Student t tests. Total cholesterol, high-density lipoprotein cholesterol, high-density lipoprotein subfraction 2, and apolipoprotein A-I concentrations were not significantly changed from baseline. Neither was the ratio of high-density lipoprotein subfraction 2 to high-density lipoprotein subfraction 3. Mean percentage increases in concentrations of triglyceride, high-density lipoprotein subfraction 3, apolipoprotein B, and low-density lipoprotein cholesterol and increases in the ratios of total cholesterol to high-density lipoprotein cholesterol, low-density lipoprotein cholesterol to high-density lipoprotein cholesterol, and apolipoprotein B to apolipoprotein A-I were significant (P <.05) at >/=1 cycle. By cycle 24, however, only the concentration of high-density lipoprotein subfraction 3 remained significantly elevated. Changes in the plasma lipid profiles among women receiving monophasic 100 microg levonorgestrel with 20 microg ethinyl estradiol were similar to those seen with other low-dose oral contraceptives, but by cycle 24 only 1 of 7 mean values remained significantly different from baseline.

Differences in lipid profiles in two Hispanic ischemic stroke populations.

PubMed

Arauz, A; Romano, J G; Ruiz-Franco, A; Shang, T; Dong, C; Rundek, T; Koch, S; Hernández-Curiel, B; Pacheco, J; Rojas, P; Ruiz-Navarro, F; Katsnelson, M; Sacco, R L

2014-06-01

The study aims to compare lipid profiles among ischemic stroke patients in a predominantly Caribbean-Hispanic population in Miami and a Mestizo Hispanic population in Mexico City. We analyzed ischemic stroke Hispanic patients with complete baseline fasting lipid profile enrolled contemporaneously in the prospective registries of two tertiary care teaching hospitals in Mexico City and Miami. Demographic characteristics, risk factors, medications, ischemic stroke subtype, and first fasting lipid profile were compared. Vascular risk factor definitions were standardized. Multiple linear regression analysis was performed to compare lipid fractions. A total of 324 patients from Mexico and 236 from Miami were analyzed. Mexicans were significantly younger (58 · 1 vs. 67 · 4 years), had a lower frequency of hypertension (53 · 4% vs. 79 · 7%), and lower body mass index (27 vs. 28 · 5). There was a trend toward greater prevalence of diabetes in Mexicans (31 · 5 vs. 24 · 6%, P = 0 · 07). Statin use at the time of ischemic stroke was more common in Miami Hispanics (18 · 6 vs. 9 · 4%). Mexicans had lower total cholesterol levels (169 · 9 ± 46 · 1 vs. 179 · 9 ± 48 · 4 mg/dl), lower low-density lipoprotein (92 · 3 ± 37 · 1 vs. 108 · 2 ± 40 · 8 mg/dl), and higher triglyceride levels (166 · 9 ± 123 · 9 vs. 149 · 2 ± 115 · 2 mg/dl). These differences remained significant after adjusting for age, gender, hypertension, diabetes, body mass index, smoking, ischemic stroke subtype, and statin use. We found significant differences in lipid fractions in Hispanic ischemic stroke patients, with lower total cholesterol and low-density lipoprotein, and higher triglyceride levels in Mexicans. These findings highlight the heterogeneity of dyslipidemia among the Hispanic race-ethnic group and may lead to different secondary prevention strategies. © 2013 The Authors. International Journal of Stroke © 2013 World Stroke Organization.

The role of dietary fat on the association between dietary amino acids and serum lipid profile in European adolescents participating in the HELENA Study.

PubMed

Bel-Serrat, S; Mouratidou, T; Huybrechts, I; Cuenca-García, M; Manios, Y; Gómez-Martínez, S; Molnár, D; Kafatos, A; Gottrand, F; Widhalm, K; Sjöström, M; Wästlund, A; Stehle, P; Azzini, E; Vyncke, K; González-Gross, M; Moreno, L A

2014-04-01

The objective of this study was to examine the relationship between amino acid (AA) intake and serum lipid profile in European adolescents from eight European cities participating in the cross-sectional (2006-2007) HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) study, and to assess whether this association was independent of total fat intake. Diet, skinfold thickness, triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), TC/HDL-c ratio, low-density lipoprotein cholesterol (LDL-c), apolipoprotein B (Apo B), apolipoprotein A1 (Apo A1) and Apo B/Apo A1 ratio were measured in 454 12.5- to 17.5-year-old adolescents (44% boys). Intake was assessed via two non-consecutive 24-h dietary recalls. Data on maternal education and sedentary behaviors were obtained via questionnaires. Physical activity was objectively measured by accelerometry. Alanine, arginine, asparaginic acid, glycine, histidine, lysine and serine intakes were inversely associated with serum TG concentrations in both boys and girls. Intake of other AA like alanine and/or arginine was also inversely associated with serum TC, LDL-c and Apo B/Apo A1 ratio only in girls. An inverse association was observed between intakes of alanine, isoleucine, leucine, methionine, serine, tryptophan, tyrosine and valine and TC/HDL-c ratio among female adolescents. Similar results were found in males for serine and tryptophan intakes. It is noteworthy, however, that associations were no longer significant in both genders when total fat intake was considered as a confounding factor. In this sample of adolescents, the association between AA intakes and serum lipid profile did not persist when dietary fat was considered. Therefore, dietary interventions and health promotion activities should focus on fat intake to improve lipid profile and potentially prevent cardiovascular disease.

SOD2 gene polymorphism and response of oxidative stress parameters in young wrestlers to a three-month training.

PubMed

Jówko, Ewa; Gierczuk, Dariusz; Cieśliński, Igor; Kotowska, Jadwiga

2017-05-01

The aim of the study was to analyse the effect of Val 16Ala polymorphism in SOD2 gene on oxidative stress parameters and lipid profile of the blood during a three-month wrestling training. The study included 53 Polish young wrestlers. Blood samples were collected at the beginning of the programme and following three months of the training. The list of analysed parameters included erythrocyte and serum activities of superoxide dismutase (SOD), whole blood glutathione peroxidase (GPx) activity, total glutathione (tGSH) level, concentration of lipid hydroperoxides (LHs), total antioxidant capacity (TAC) and creatine kinase (CK) activity in the serum, as well as lipid profile parameters: triglycerides (TG), total cholesterol (TC), high-density (HDL-C), and low-density lipoprotein cholesterol (LDL-C). Three-month training resulted in a decrease in CK activity, an increase in serum SOD activity, as well as in unfavourable changes in serum lipid profile: an increase in TC, LDL-C, and TG, and a decrease in HDL-C. Aside from CK activity, all these changes seemed to be associated with presence of Val allele. Prior to the training programme, subjects with Ala/Ala genotype presented with lower levels of LHs, lower whole blood GPx activity, and lower serum concentrations of TC than the individuals with Ala/Val genotype. Both prior to and after three-month training, higher levels of tGSH were observed in Val/Val genotype as compared to Ala/Val genotype carriers. Moreover, multiple regression analysis demonstrated that SOD2 genotype was a significant predictor of pre-training whole blood GPx activity and erythrocyte SOD activity (Val/Val > Ala/Val > Ala/Ala). Altogether, these findings suggest that Val 16Ala polymorphism in SOD2 gene contributes to individual variability in oxidative stress status and lipid profile of the blood in young wrestlers, and may modulate biochemical response to training.

THE CIRCUMSTELLAR DISK OF THE Be STAR o AQUARII AS CONSTRAINED BY SIMULTANEOUS SPECTROSCOPY AND OPTICAL INTERFEROMETRY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sigut, T. A. A.; Tycner, C.; Jansen, B.

Omicron Aquarii is a late-type, Be shell star with a stable and nearly symmetric Hα emission line. We combine Hα interferometric observations obtained with the Navy Precision Optical Interferometer covering 2007 through 2014 with Hα spectroscopic observations over the same period and a 2008 observation of the system's near-infrared spectral energy distribution to constrain the properties of o Aqr's circumstellar disk. All observations are consistent with a circumstellar disk seen at an inclination of 75° ±  3° with a position angle on the sky of 110° ±  8° measured East from North. From the best-fit disk density model, we find that 90% ofmore » the Hα emission arises from within 9.5 stellar radii, and the mass associated with this Hα disk is ∼1.8 × 10{sup −10} of the stellar mass, and that the associated angular momentum, assuming Keplerian rotation for the disk, is ∼1.6 × 10{sup −8} of the total stellar angular momentum. The occurrence of a central quasi-emission feature in Mg ii λ4481 is also predicted by this best-fit disk model and the computed profile compares successfully with observations from 1999. To obtain consistency between the Hα line profile modeling and the other constraints, it was necessary in the profile fitting to weight the line core (emission peaks and central depression) more heavily than the line wings, which were not well reproduced by our models. This may reflect the limitation of assuming a single power law for the disk's variation in equatorial density. The best-fit disk density model for o Aqr predicts that Hα is near its maximum strength as a function of disk density, and hence the Hα equivalent width and line profile change only weakly in response to large (factor of ∼5) changes in the disk density. This may in part explain the remarkable observed stability of o Aqr's Hα emission line profile.« less

Usefulness of the LDL-C/apoB ratio in the overall evaluation of atherogenicity of lipid profile.

PubMed

Kaneva, Anastasiya M; Potolitsyna, Natalya N; Bojko, Evgeny R

2017-02-01

The ratio of low-density lipoprotein cholesterol to apolipoprotein-B (LDL-C/apoB) conventionally represents an alternative index of LDL particle size. This study was undertaken to determine the importance of LDL-C/apoB ratio in the overall evaluation of atherogenicity of lipid profile. The plasma levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), apolipoprotein (apo) A-I, apoB and apoE were measured in 186 apparently healthy men using enzymatic and immunoturbidimetric methods. The subjects with low values of the LDL-C/apoB ratio, indicating a predominance of small dense LDL (sd-LDL) particles in plasma, were characterized by higher TG levels and lower apoE levels. Low levels of apoE are most likely a cause of reduced clearance of TG-rich lipoproteins, which promotes the formation of sd-LDL. Determination of the LDL-C/apoB ratio can be used for monitoring qualitative changes in lipid profile, in addition to traditional lipid variables indicating quantitative changes.

Efficacy of the Hydroalcoholic Extract of Tribulus terrestris on the Serum Glucose and Lipid Profile of Women With Diabetes Mellitus: A Double-Blind Randomized Placebo-Controlled Clinical Trial.

PubMed

Samani, Nasrin Babadaei; Jokar, Azam; Soveid, Mahmood; Heydari, Mojtaba; Mosavat, Seyed Hamdollah

2016-10-01

Considering traditional use of Tribulus terrestris in diabetes and proven antihyperglycemic and antihyperlipidemic effects of T terrestris in animal studies, we aimed to evaluate the efficacy of the hydroalcoholic extract of T terrestris on the serum glucose and lipid profile of women with non-insulin-dependent diabetes mellitus. Ninety-eight women with diabetes mellitus type 2 were randomly allocated to receive the T terrestris (1000 mg/d) or placebo for 3 months. The patients were evaluated in terms of the fasting blood glucose, 2-hour postprandial glucose, glycosylated hemoglobin, and lipid profile. Tribulus terrestris showed a significant blood glucose-lowering effect in diabetic women compared to placebo (P < .05). Also, the total cholesterol and low-density lipoprotein of T terrestris group was significantly reduced compared with placebo, while no significant effect was observed in the triglyceride and high-density lipoprotein levels. The study showed preliminary promising hypoglycemic effect of T terrestris in women with diabetes mellitus type 2. © The Author(s) 2016.

Physical Theory of Voltage Fade in Lithium- and Manganese-Rich Transition Metal Oxides

DOE PAGES

Rinaldo, Steven G.; Gallagher, Kevin G.; Long, Brandon R.; ...

2015-03-04

Lithium- and manganese-rich (LMR) transition metal oxide cathodes are of interest for lithium-ion battery applications due to their increased energy density and decreased cost. However, the advantages in energy density and cost are offset, in part, due to the phenomena of voltage fade. Specifically, the voltage profiles (voltage as a function of capacity) of LMR cathodes transform from a high energy configuration to a lower energy configuration as they are repeatedly charged (Li removed) and discharged (Li inserted). Here, we propose a physical model of voltage fade that accounts for the emergence of a low voltage Li phase due tomore » the introduction of transition metal ion defects within a parent Li phase. The phenomenological model was re-cast in a general form and experimental LMR charge profiles were de-convoluted to extract the evolutionary behavior of various components of LMR capacitance profiles. Evolution of the voltage fade component was found to follow a universal growth curve with a maximal voltage fade capacity of ≈ 20% of the initial total capacity.« less

Carbon Nanotube Oscillator Surface Profiling Device and Method of Use

DTIC Science & Technology

2011-11-15

distance p. The constants A and B are the Hamaker constants, which depend on the materials of the two interacting bodies. The total vdW inter...wall CNT 45 with 2L1 =2L2 =150 A and a sample of specific material char- acterized with atomic density a, Hamaker constants A and B, and a friction

Two-dimensional AXUV-based radiated power density diagnostics on NSTX-Ua)

NASA Astrophysics Data System (ADS)

Faust, I.; Delgado-Aparicio, L.; Bell, R. E.; Tritz, K.; Diallo, A.; Gerhardt, S. P.; LeBlanc, B.; Kozub, T. A.; Parker, R. R.; Stratton, B. C.

2014-11-01

A new set of radiated-power-density diagnostics for the National Spherical Torus Experiment Upgrade (NSTX-U) tokamak have been designed to measure the two-dimensional poloidal structure of the total photon emissivity profile in order to perform power balance, impurity transport, and magnetohydrodynamic studies. Multiple AXUV-diode based pinhole cameras will be installed in the same toroidal angle at various poloidal locations. The local emissivity will be obtained from several types of tomographic reconstructions. The layout and response expected for the new radially viewing poloidal arrays will be shown for different impurity concentrations to characterize the diagnostic sensitivity. The radiated power profile inverted from the array data will also be used for estimates of power losses during transitions from various divertor configurations in NSTX-U. The effect of in-out and top/bottom asymmetries in the core radiation from high-Z impurities will be addressed.

Two-dimensional AXUV-based radiated power density diagnostics on NSTX-U.

PubMed

Faust, I; Delgado-Aparicio, L; Bell, R E; Tritz, K; Diallo, A; Gerhardt, S P; LeBlanc, B; Kozub, T A; Parker, R R; Stratton, B C

2014-11-01

A new set of radiated-power-density diagnostics for the National Spherical Torus Experiment Upgrade (NSTX-U) tokamak have been designed to measure the two-dimensional poloidal structure of the total photon emissivity profile in order to perform power balance, impurity transport, and magnetohydrodynamic studies. Multiple AXUV-diode based pinhole cameras will be installed in the same toroidal angle at various poloidal locations. The local emissivity will be obtained from several types of tomographic reconstructions. The layout and response expected for the new radially viewing poloidal arrays will be shown for different impurity concentrations to characterize the diagnostic sensitivity. The radiated power profile inverted from the array data will also be used for estimates of power losses during transitions from various divertor configurations in NSTX-U. The effect of in-out and top/bottom asymmetries in the core radiation from high-Z impurities will be addressed.

Tomography Reconstruction of Ionospheric Electron Density with Empirical Orthonormal Functions Using Korea GNSS Network

NASA Astrophysics Data System (ADS)

Hong, Junseok; Kim, Yong Ha; Chung, Jong-Kyun; Ssessanga, Nicholas; Kwak, Young-Sil

2017-03-01

In South Korea, there are about 80 Global Positioning System (GPS) monitoring stations providing total electron content (TEC) every 10 min, which can be accessed through Korea Astronomy and Space Science Institute (KASI) for scientific use. We applied the computerized ionospheric tomography (CIT) algorithm to the TEC dataset from this GPS network for monitoring the regional ionosphere over South Korea. The algorithm utilizes multiplicative algebraic reconstruction technique (MART) with an initial condition of the latest International Reference Ionosphere-2016 model (IRI-2016). In order to reduce the number of unknown variables, the vertical profiles of electron density are expressed with a linear combination of empirical orthonormal functions (EOFs) that were derived from the IRI empirical profiles. Although the number of receiver sites is much smaller than that of Japan, the CIT algorithm yielded reasonable structure of the ionosphere over South Korea. We verified the CIT results with NmF2 from ionosondes in Icheon and Jeju and also with GPS TEC at the center of South Korea. In addition, the total time required for CIT calculation was only about 5 min, enabling the exploration of the vertical ionospheric structure in near real time.

Density profiles around A+B→C reaction-diffusion fronts in partially miscible systems: A general classification.

PubMed

Loodts, V; Trevelyan, P M J; Rongy, L; De Wit, A

2016-10-01

Various spatial density profiles can develop in partially miscible stratifications when a phase A dissolves with a finite solubility into a host phase containing a dissolved reactant B. We investigate theoretically the impact of an A+B→C reaction on such density profiles in the host phase and classify them in a parameter space spanned by the ratios of relative contributions to density and diffusion coefficients of the chemical species. While the density profile is either monotonically increasing or decreasing in the nonreactive case, reactions combined with differential diffusivity can create eight different types of density profiles featuring up to two extrema in density, at the reaction front or below it. We use this framework to predict various possible hydrodynamic instability scenarios inducing buoyancy-driven convection around such reaction fronts when they propagate parallel to the gravity field.

Primordial inhomogeneities in the expanding universe. II - General features of spherical models at late times

NASA Technical Reports Server (NTRS)

Olson, D. W.; Silk, J.

1979-01-01

This paper studies the density profile that forms around a spherically symmetric bound central core immersed in a homogeneous-background k = 0 or k = -1 Friedmann-Robertson-Walker cosmological model, with zero pressure. Although the density profile in the linearized regime is almost arbitrary, in the nonlinear regime certain universal features of the density profile are obtained that are independent of the details of the initial conditions. The formation of 'halos' ('holes') with densities greater than (less than) the average cosmological density is discussed. It is shown that in most regions 'halos' form, and universal values are obtained for the slope of the ln (density)-ln (radius) profile in those 'halos' at late times, independently of the shape of the initial density profile. Restrictions are derived on where it is possible for 'holes' to exist at late times and on how such 'holes' must have evolved.

The XMM Cluster Outskirts Project (X-COP): Thermodynamic properties of the intracluster medium out to R200 in Abell 2319

NASA Astrophysics Data System (ADS)

Ghirardini, V.; Ettori, S.; Eckert, D.; Molendi, S.; Gastaldello, F.; Pointecouteau, E.; Hurier, G.; Bourdin, H.

2018-06-01

Aims: We present the joint analysis of the X-ray and Sunyaev-Zel'dovich (SZ) signals in Abell 2319, the galaxy cluster with the highest signal-to-noise ratio in SZ Planck maps and that has been surveyed within our XMM-Newton Cluster Outskirts Project (X-COP), a very large program which aims to grasp the physical condition in 12 local (z < 0.1) and massive (M200 > 3 × 1014 M⊙) galaxy clusters out to R200 and beyond. Methods: We recover the profiles of the thermodynamic properties by the geometrical deprojection of the X-ray surface brightness, of the SZ Comptonization parameter, and accurate and robust spectroscopic measurements of the gas temperature out to 3.2 Mpc (1.6 R200), 4 Mpc (2 R200), and 1.6 Mpc (0.8 R200), respectively. We resolve the clumpiness of the gas density to be below 20% over the entire observed volume. We also demonstrate that most of this clumpiness originates from the ongoing merger and can be associated with large-scale inhomogeneities (the "residual" clumpiness). We estimate the total mass through the hydrostatic equilibrium equation. This analysis is done both in azimuthally averaged radial bins and in eight independent angular sectors, enabling us to study in detail the azimuthal variance of the recovered properties. Results: Given the exquisite quality of the X-ray and SZ datasets, their radial extension, and their complementarity, we constrain at R200 the total hydrostatic mass, modelled with a Navarro-Frenk-White profile at very high precision (M200 = 10.7 ± 0.5stat. ± 0.9syst. × 1014 M⊙). We identify the ongoing merger and how it is affecting differently the gas properties in the resolved azimuthal sectors. We have several indications that the merger has injected a high level of non-thermal pressure in this system: the clumping free density profile is above the average profile obtained by stacking Rosat/PSPC observations; the gas mass fraction recovered using our hydrostatic mass profile exceeds the expected cosmic gas fraction beyond R500; the pressure profile is flatter than the fit obtained by the Planck Collaboration; the entropy profile is flatter than the mean profile predicted from non-radiative simulations; the analysis in azimuthal sectors has revealed that these deviations occur in a preferred region of the cluster. All these tensions are resolved by requiring a relative support of about 40% from non-thermal to the total pressure at R200.

Density profile and fiber alignment in fiberboard from three southern hardwoods

Treesearch

George E. Woodson

1977-01-01

Density profile and fiber orientation were evaluated for their effects on selected mechanical properties of medium density fiberboard. Bending MOE and modulus of rigidity were predicted from density profiles established by x-ray radiography. Orthotropic ratios ranged from 1.19 to 2.32 for electrically aligned fiberboards from three southern hardwoods. Off-axis tensile...

Dark energy and the structure of the Coma cluster of galaxies

NASA Astrophysics Data System (ADS)

Chernin, A. D.; Bisnovatyi-Kogan, G. S.; Teerikorpi, P.; Valtonen, M. J.; Byrd, G. G.; Merafina, M.

2013-05-01

Context. We consider the Coma cluster of galaxies as a gravitationally bound physical system embedded in the perfectly uniform static dark energy background as implied by ΛCDM cosmology. Aims: We ask if the density of dark energy is high enough to affect the structure of a large and rich cluster of galaxies. Methods: We base our work on recent observational data on the Coma cluster, and apply our theory of local dynamical effects of dark energy, including the zero-gravity radius RZG of the local force field as the key parameter. Results: 1) Three masses are defined that characterize the structure of a regular cluster: the matter mass MM, the dark-energy effective mass MDE (<0), and the gravitating mass MG (=MM + MDE). 2) A new matter-density profile is suggested that reproduces the observational data well for the Coma cluster in the radius range from 1.4 Mpc to 14 Mpc and takes the dark energy background into account. 3) Using this profile, we calculate upper limits for the total size of the Coma cluster, R ≤ RZG ≈ 20 Mpc, and its total matter mass, MM ≲ MM(RZG) = 6.2 × 1015 M⊙. Conclusions: The dark energy antigravity affects the structure of the Coma cluster strongly at large radii R ≳ 14 Mpc and should be considered when its total mass is derived.

Effects of antioxidant vitamins (A, D, E) and trace elements (Cu, Mn, Se, Zn) on some metabolic and reproductive profiles in dairy cows during transition period.

PubMed

Omur, A; Kirbas, A; Aksu, E; Kandemir, F; Dorman, E; Kaynar, O; Ucar, O

2016-12-01

The objective of this study was to determine the effects of some antioxidant vitamins and trace elements on some metabolic and postpartum reproductive profiles in dairy cows during transition period. In the study, altogether 20 clinically healthy Brown Swiss dairy cows (aged 4-5 years-old) under the same management and feeding conditions in periparturient period were used. The animals were divided into two equal groups: control (C) and treatment (T) group (n=10 for each group). Vitamins (A, D, E) and trace elements (Cu, Mn, Se, Zn) were administered intramuscularly into the cows of the T group, while isotonic saline, as placebo, was injected subcutaneously into those in the C group. Blood samples were collected by venipuncture of the jugular vein at the beginning of transition period, parturition and 3-weeks after the parturition. The metabolic and reproductive parameters were determined. In the C group, statistically significant changes were observed in the levels of non-esterified fatty acids (NEFA), high density lipoprotein (HDL), low density lipoprotein (LDL), total protein (TP) (p<0.05), glucose (GLU), progesterone (P4) (p<0.01), total cholesterol (T.CHOL), triglycerides (TG), UREA, creatinine (CRSC) and total bilirubin (TBIL) (p<0.001). In the T group, significant changes in the levels of NEFA, TBIL (p<0.05), T.CHOL, HDL, LDL (p<0.01), TG, GLU, P4, TAC and TOC (p<0.001) were observed. It was concluded that the administration of various vitamins and trace elements could be effective to improve some metabolic and reproductive profiles in dairy cows during the transition period.

Metabolic Profile as a Potential Modifier of Long-Term Radiation Effects on Peripheral Lymphocyte Subsets in Atomic Bomb Survivors.

PubMed

Yoshida, Kengo; Nakashima, Eiji; Kyoizumi, Seishi; Hakoda, Masayuki; Hayashi, Tomonori; Hida, Ayumi; Ohishi, Waka; Kusunoki, Yoichiro

2016-09-01

Immune system impairments reflected by the composition and function of circulating lymphocytes are still observed in atomic bomb survivors, and metabolic abnormalities including altered blood triglyceride and cholesterol levels have also been detected in such survivors. Based on closely related features of immune and metabolic profiles of individuals, we investigated the hypothesis that long-term effects of radiation exposure on lymphocyte subsets might be modified by metabolic profiles in 3,113 atomic bomb survivors who participated in health examinations at the Radiation Effect Research Foundation, Hiroshima and Nagasaki, in 2000-2002. The lymphocyte subsets analyzed involved T-, B- and NK-cell subsets, and their percentages in the lymphocyte fraction were assessed using flow cytometry. Health examinations included metabolic indicators, body mass index, serum levels of total cholesterol, high-density lipoprotein cholesterol, C-reactive protein and hemoglobin A1c, as well as diabetes and fatty liver diagnoses. Standard regression analyses indicated that several metabolic indicators of obesity/related disease, particularly high-density lipoprotein cholesterol levels, were positively associated with type-1 helper T- and B-cell percentages but were inversely associated with naïve CD4 T and NK cells. A regression analysis adjusted for high-density lipoprotein cholesterol revealed a radiation dose relationship with increasing NK-cell percentage. Additionally, an interaction effect was suggested between radiation dose and C-reactive protein on B-cell percentage with a negative coefficient of the interaction term. Collectively, these findings suggest that radiation exposure and subsequent metabolic profile changes, potentially in relationship to obesity-related inflammation, lead to such long-term alterations in lymphocyte subset composition. Because this study is based on cross-sectional and exploratory analyses, the implications regarding radiation exposure, metabolic profiles and circulating lymphocytes warrant future longitudinal and molecular mechanistic studies.

THEMIS two‐point measurements of the cross‐tail current density: A thick bifurcated current sheet in the near‐Earth plasma sheet

PubMed Central

2015-01-01

Abstract The basic properties of the near‐Earth current sheet from 8 RE to 12 RE were determined based on Time History of Events and Macroscale Interactions during Substorms (THEMIS) observations from 2007 to 2013. Ampere's law was used to estimate the current density when the locations of two spacecraft were suitable for the calculation. A total of 3838 current density observations were obtained to study the vertical profile. For typical solar wind conditions, the current density near (off) the central plane of the current sheet ranged from 1 to 2 nA/m2 (1 to 8 nA/m2). All the high current densities appeared off the central plane of the current sheet, indicating the formation of a bifurcated current sheet structure when the current density increased above 2 nA/m2. The median profile also showed a bifurcated structure, in which the half thickness was about 3 RE. The distance between the peak of the current density and the central plane of the current sheet was 0.5 to 1 RE. High current densities above 4 nA/m2 were observed in some cases that occurred preferentially during substorms, but they also occurred in quiet times. In contrast to the commonly accepted picture, these high current densities can form without a high solar wind dynamic pressure. In addition, these high current densities can appear in two magnetic configurations: tail‐like and dipolar structures. At least two mechanisms, magnetic flux depletion and new current system formation during the expansion phase, other than plasma sheet compression are responsible for the formation of the bifurcated current sheets. PMID:27722039

Model-based Optimization and Feedback Control of the Current Density Profile Evolution in NSTX-U

NASA Astrophysics Data System (ADS)

Ilhan, Zeki Okan

Nuclear fusion research is a highly challenging, multidisciplinary field seeking contributions from both plasma physics and multiple engineering areas. As an application of plasma control engineering, this dissertation mainly explores methods to control the current density profile evolution within the National Spherical Torus eXperiment-Upgrade (NSTX-U), which is a substantial upgrade based on the NSTX device, which is located in Princeton Plasma Physics Laboratory (PPPL), Princeton, NJ. Active control of the toroidal current density profile is among those plasma control milestones that the NSTX-U program must achieve to realize its next-step operational goals, which are characterized by high-performance, long-pulse, MHD-stable plasma operation with neutral beam heating. Therefore, the aim of this work is to develop model-based, feedforward and feedback controllers that can enable time regulation of the current density profile in NSTX-U by actuating the total plasma current, electron density, and the powers of the individual neutral beam injectors. Motivated by the coupled, nonlinear, multivariable, distributed-parameter plasma dynamics, the first step towards control design is the development of a physics-based, control-oriented model for the current profile evolution in NSTX-U in response to non-inductive current drives and heating systems. Numerical simulations of the proposed control-oriented model show qualitative agreement with the high-fidelity physics code TRANSP. The next step is to utilize the proposed control-oriented model to design an open-loop actuator trajectory optimizer. Given a desired operating state, the optimizer produces the actuator trajectories that can steer the plasma to such state. The objective of the feedforward control design is to provide a more systematic approach to advanced scenario planning in NSTX-U since the development of such scenarios is conventionally carried out experimentally by modifying the tokamak's actuator trajectories and analyzing the resulting plasma evolution. Finally, the proposed control-oriented model is embedded in feedback control schemes based on optimal control and Model Predictive Control (MPC) approaches. Integrators are added to the standard Linear Quadratic Gaussian (LQG) and MPC formulations to provide robustness against various modeling uncertainties and external disturbances. The effectiveness of the proposed feedback controllers in regulating the current density profile in NSTX-U is demonstrated in closed-loop nonlinear simulations. Moreover, the optimal feedback control algorithm has been implemented successfully in closed-loop control simulations within TRANSP through the recently developed Expert routine. (Abstract shortened by ProQuest.).

A systematic review on evidence of the effectiveness and safety of a wax-matrix niacin formulation.

PubMed

Dunatchik, Andrew P; Ito, Matthew K; Dujovne, Carlos A

2012-01-01

Niacin is a uniquely efficacious therapy in the treatment of dyslipidemia because of its broad spectrum of beneficial effects on every aspect of the lipid profile and because it has been shown to reduce both total mortality and coronary death. However, niacin therapy is hindered by its side-effect profile, which appears to be dependent on its formulation with immediate-release niacin, associated with a greater incidence of flushing, and sustained-release niacin, associated with greater liver function test (LFT) abnormalities and hepatotoxicity. One such sustained-release niacin nutritional supplement formulation, Endur-acin (Endurance Products Company, Tigard, OR), claims to have clinical evidence to support its use in the treatment of dyslipidemias, which prompted us to systematically review the literature. We identified four published papers in which the authors reported the results of two separate clinical trials and one pharmacokinetic study that fulfilled the inclusion criteria and were included in this review. Endur-acin significantly reduced total cholesterol, low-density lipoprotein cholesterol, and total cholesterol/high-density lipoprotein cholesterol ratio with mean reductions up to 19%, 26%, and 20%, respectively, at a dose of 2000 mg/day. Less-impressive benefits were also seen with high-density lipoprotein cholesterol (+10%) and serum triglycerides (-23%). Mean LFT elevations of up to 1.6-fold were seen at the 2000 mg per day dose, however, not exceeding three times the upper limit of normal, with abnormal results occurring at similar frequency in placebo and one patient experiencing marked gastrointestinal symptoms and a hepatitis-like syndrome with reversible elevated LFT. Short-term randomized controlled trials suggest Endur-acin is effective in modifying serum lipids, although study limitations prevent a comprehensive evaluation of safety. Copyright © 2012 National Lipid Association. Published by Elsevier Inc. All rights reserved.

Dietary Supplementation with Virgin Coconut Oil Improves Lipid Profile and Hepatic Antioxidant Status and Has Potential Benefits on Cardiovascular Risk Indices in Normal Rats.

PubMed

Famurewa, Ademola C; Ekeleme-Egedigwe, Chima A; Nwali, Sophia C; Agbo, Ngozi N; Obi, Joy N; Ezechukwu, Goodness C

2018-05-04

Research findings that suggest beneficial health effects of dietary supplementation with virgin coconut oil (VCO) are limited in the published literature. This study investigated the in vivo effects of a 5-week VCO-supplemented diet on lipid profile, hepatic antioxidant status, hepatorenal function, and cardiovascular risk indices in normal rats. Rats were randomly divided into 3 groups: 1 control and 2 treatment groups (10% and 15% VCO-supplemented diets) for 5 weeks. Serum and homogenate samples were used to analyze lipid profile, hepatorenal function markers, hepatic activities of antioxidant enzymes, and malondialdehyde level. Lipid profile of animals fed VCO diets showed significant reduction in total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL) levels; high-density lipoprotein (HDL) level increased significantly (p < .05) compared to control; and there were beneficial effects on cardiovascular risk indices. The level of malondialdehyde (MDA), a lipid peroxidation marker, remarkably reduced and activities of hepatic antioxidant enzymes-superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)-were markedly increased in VCO diet-fed rats. The VCO diet significantly modulated creatinine, sodium (Na + ), potassium (K + ), chloride (Cl - ), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) compared to control. The findings suggest a beneficial effect of VCO on lipid profile, renal status, hepatic antioxidant defense system, and cardiovascular risk indices in rats.

Stellar mass distribution of S4G disk galaxies and signatures of bar-induced secular evolution

NASA Astrophysics Data System (ADS)

Díaz-García, S.; Salo, H.; Laurikainen, E.

2016-12-01

Context. Models of galaxy formation in a cosmological framework need to be tested against observational constraints, such as the average stellar density profiles (and their dispersion) as a function of fundamental galaxy properties (e.g. the total stellar mass). Simulation models predict that the torques produced by stellar bars efficiently redistribute the stellar and gaseous material inside the disk, pushing it outwards or inwards depending on whether it is beyond or inside the bar corotation resonance radius. Bars themselves are expected to evolve, getting longer and narrower as they trap particles from the disk and slow down their rotation speed. Aims: We use 3.6 μm photometry from the Spitzer Survey of Stellar Structure in Galaxies (S4G) to trace the stellar distribution in nearby disk galaxies (z ≈ 0) with total stellar masses 108.5 ≲ M∗/M⊙ ≲ 1011 and mid-IR Hubble types - 3 ≤ T ≤ 10. We characterize the stellar density profiles (Σ∗), the stellar contribution to the rotation curves (V3.6 μm), and the m = 2 Fourier amplitudes (A2) as a function of M∗ and T. We also describe the typical shapes and strengths of stellar bars in the S4G sample and link their properties to the total stellar mass and morphology of their host galaxy. Methods: For 1154 S4G galaxies with disk inclinations lower than 65°, we perform a Fourier decomposition and rescale their images to a common frame determined by the size in physical units, by their disk scalelength, and for 748 barred galaxies by both the length and orientation of their bars. We stack the resized density profiles and images to obtain statistically representative average stellar disks and bars in bins of M∗ and T. Based on the radial force profiles of individual galaxies we calculate the mean stellar contribution to the circular velocity. We also calculate average A2 profiles, where the radius is normalized to R25.5. Furthermore, we infer the gravitational potentials from the synthetic bars to obtain the tangential-to-radial force ratio (QT) and A2 profiles in the different bins. We also apply ellipse fitting to quantitatively characterize the shape of the bar stacks. Results: For M∗ ≥ 109M⊙, we find a significant difference in the stellar density profiles of barred and non-barred systems: (I) disks in barred galaxies show larger scalelengths (hR) and fainter extrapolated central surface brightnesses (Σ°); (II) the mean surface brightness profiles (Σ∗) of barred and non-barred galaxies intersect each other slightly beyond the mean bar length, most likely at the bar corotation; and (III) the central mass concentration of barred galaxies is higher (by almost a factor 2 when T ≤ 5) than in their non-barred counterparts. The averaged Σ∗ profiles follow an exponential slope down to at least 10 M⊙ pc-2, which is the typical depth beyond which the sample coverage in the radial direction starts to drop. Central mass concentrations in massive systems (≥1010M⊙) are substantially larger than in fainter galaxies, and their prominence scales with T. This segregation also manifests in the inner slope of the mean stellar component of the circular velocity: lenticular (S0) galaxies present the most sharply rising V3.6 μm. Based on the analysis of bar stacks, we show that early- and intermediate-type spirals (0 ≤ T< 5) have intrinsically narrower bars than later types and S0s, whose bars are oval-shaped. We show a clear agreement between galaxy family and quantitative estimates of bar strength. In early- and intermediate-type spirals, A2 is larger within and beyond the typical bar region among barred galaxies than in the non-barred subsample. Strongly barred systems also tend to have larger A2 amplitudes at all radii than their weakly barred counterparts. Conclusions: Using near-IR wavelengths (S4G 3.6 μm), we provide observational constraints that galaxy formation models can be checked against. In particular, we calculate the mean stellar density profiles, and the disk(+bulge) component of the rotation curve (and their dispersion) in bins of M∗ and T. We find evidence for bar-induced secular evolution of disk galaxies in terms of disk spreading and enhanced central mass concentration. We also obtain average bars (2D), and we show that bars hosted by early-type galaxies are more centrally concentrated and have larger density amplitudes than their late-type counterparts. The FITS files of the synthetic images and the tabulated radial profiles of the mean (and dispersion of) stellar mass density, 3.6 μm surface brightness, Fourier amplitudes, gravitational force, and the stellar contribution to the circular velocity are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/596/A84

Effects of Different Types of Statins on Lipid Profile: A Perspective on Asians.

PubMed

Meor Anuar Shuhaili, Meor Fairuz Rizal; Samsudin, Intan Nureslyna; Stanslas, Johnson; Hasan, Shariful; Thambiah, Subashini C

2017-04-01

The present review aimed at reviewing the effects of different statins on lipid profile, particularly in Asians. PubMed searches were conducted using the keywords 'statin, effect, and lipid profile' from database inception through March 2016. In this review, 718 articles were retrieved from the primary search. After reviewing the titles, abstracts, and full texts, we found that 59 studies met our inclusion criteria. These also included subsequent reference searches of retrieved articles. CURVES study compared the effect on lipid profile between atorvastatin and other statins. This study demonstrated that low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG) were reduced more with atorvastatin compared to simvastatin, pravastatin, lovastatin, and fluvastatin. However, simvastatin provided a greater elevation of high-density lipoprotein cholesterol (HDL-C) compared to atorvastatin. The STELLAR trial was based on dose-to-dose comparisons between atorvastatin and rosuvastatin efficacy in reducing LDL-C. Te present study also revealed that as the doses of rosuvastatin, simvastatin, and pravastatin increased, HDL-C also increased, with rosuvastatin having the greatest effect. However, HDL-C levels decreased as the dose of atorvastatin increased. The DISCOVERY study involving the Asian population revealed that the percentage of patients achieving the European goals for LDL-C and TC at 12 weeks was higher in rosuvastatin group compared to atorvastatin group. The effects of statins on lipid profile are dose dependent. Most studies showed that rosuvastatin has the best effect on lipid profile. Prescribing lower doses of statins in Asians seems necessary.

Tsunami Speed Variations in Density-stratified Compressible Global Oceans

NASA Astrophysics Data System (ADS)

Watada, S.

2013-12-01

Recent tsunami observations in the deep ocean have accumulated unequivocal evidence that tsunami traveltime delays compared with the linear long-wave tsunami simulations occur during tsunami propagation in the deep ocean. The delay is up to 2% of the tsunami traveltime. Watada et al. [2013] investigated the cause of the delay using the normal mode theory of tsunamis and attributed the delay to the compressibility of seawater, the elasticity of the solid earth, and the gravitational potential change associated with mass motion during the passage of tsunamis. Tsunami speed variations in the deep ocean caused by seawater density stratification is investigated using a newly developed propagator matrix method that is applicable to seawater with depth-variable sound speeds and density gradients. For a 4-km deep ocean, the total tsunami speed reduction is 0.45% compared with incompressible homogeneous seawater; two thirds of the reduction is due to elastic energy stored in the water and one third is due to water density stratification mainly by hydrostatic compression. Tsunami speeds are computed for global ocean density and sound speed profiles and characteristic structures are discussed. Tsunami speed reductions are proportional to ocean depth with small variations, except for in warm Mediterranean seas. The impacts of seawater compressibility and the elasticity effect of the solid earth on tsunami traveltime should be included for precise modeling of trans-oceanic tsunamis. Data locations where a vertical ocean profile deeper than 2500 m is available in World Ocean Atlas 2009. The dark gray area indicates the Pacific Ocean defined in WOA09. a) Tsunami speed variations. Red, gray and black bars represent global, Pacific, and Mediterranean Sea, respectively. b) Regression lines of the tsunami velocity reduction for all oceans. c)Vertical ocean profiles at grid points indicated by the stars in Figure 1.

Turbulent fluctuations during pellet injection into a dipole confined plasma torus

NASA Astrophysics Data System (ADS)

Garnier, D. T.; Mauel, M. E.; Roberts, T. M.; Kesner, J.; Woskov, P. P.

2017-01-01

We report measurements of the turbulent evolution of the plasma density profile following the fast injection of lithium pellets into the Levitated Dipole Experiment (LDX) [Boxer et al., Nat. Phys. 6, 207 (2010)]. As the pellet passes through the plasma, it provides a significant internal particle source and allows investigation of density profile evolution, turbulent relaxation, and turbulent fluctuations. The total electron number within the dipole plasma torus increases by more than a factor of three, and the central density increases by more than a factor of five. During these large changes in density, the shape of the density profile is nearly "stationary" such that the gradient of the particle number within tubes of equal magnetic flux vanishes. In comparison to the usual case, when the particle source is neutral gas at the plasma edge, the internal source from the pellet causes the toroidal phase velocity of the fluctuations to reverse and changes the average particle flux at the plasma edge. An edge particle source creates an inward turbulent pinch, but an internal particle source increases the outward turbulent particle flux. Statistical properties of the turbulence are measured by multiple microwave interferometers and by an array of probes at the edge. The spatial structures of the largest amplitude modes have long radial and toroidal wavelengths. Estimates of the local and toroidally averaged turbulent particle flux show intermittency and a non-Gaussian probability distribution function. The measured fluctuations, both before and during pellet injection, have frequency and wavenumber dispersion consistent with theoretical expectations for interchange and entropy modes excited within a dipole plasma torus having warm electrons and cool ions.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang Lan; Liu Chao; Zhao Gang

To constrain the Galactic gravitational potential near the Sun ({approx}1.5 kpc), we derive and model the spatial and velocity distributions for a sample of 9000 K-dwarfs with spectra from SDSS/SEGUE, which yield radial velocities and abundances ([Fe/H] and [{alpha}/Fe]). We first derive the spatial density distribution for three abundance-selected sub-populations of stars accounting for the survey's selection function. The vertical profiles of these sub-populations are simple exponentials and their vertical dispersion profile is nearly isothermal. To model these data, we apply the 'vertical' Jeans equation, which relates the observable tracer number density and vertical velocity dispersion to the gravitational potentialmore » or vertical force. We explore a number of functional forms for the vertical force law, fit the dispersion and density profiles of all abundance-selected sub-populations simultaneously in the same potential, and explore all parameter co-variances using a Markov Chain Monte Carlo technique. Our fits constrain a disk mass scale height {approx}< 300 pc and the total surface mass density to be 67 {+-} 6 M{sub Sun} pc{sup -2} at |z| = 1.0 kpc of which the contribution from all stars is 42 {+-} 5 M{sub Sun} pc{sup -2} (assuming a contribution from cold gas of 13 M{sub Sun} pc{sup -2}). We find significant constraints on the local dark matter density of 0.0065 {+-} 0.0023 M{sub Sun} pc{sup -3} (0.25 {+-} 0.09 GeV cm{sup -3}). Together with recent experiments this firms up the best estimate of 0.0075 {+-} 0.0021 M{sub Sun} pc{sup -3} (0.28 {+-} 0.08 GeV cm{sup -3}), consistent with global fits of approximately round dark matter halos to kinematic data in the outskirts of the Galaxy.« less

Trunk density profile estimates from dual X-ray absorptiometry.

PubMed

Wicke, Jason; Dumas, Geneviève A; Costigan, Patrick A

2008-01-01

Accurate body segment parameters are necessary to estimate joint loads when using biomechanical models. Geometric methods can provide individualized data for these models but the accuracy of the geometric methods depends on accurate segment density estimates. The trunk, which is important in many biomechanical models, has the largest variability in density along its length. Therefore, the objectives of this study were to: (1) develop a new method for modeling trunk density profiles based on dual X-ray absorptiometry (DXA) and (2) develop a trunk density function for college-aged females and males that can be used in geometric methods. To this end, the density profiles of 25 females and 24 males were determined by combining the measurements from a photogrammetric method and DXA readings. A discrete Fourier transformation was then used to develop the density functions for each sex. The individual density and average density profiles compare well with the literature. There were distinct differences between the profiles of two of participants (one female and one male), and the average for their sex. It is believed that the variations in these two participants' density profiles were a result of the amount and distribution of fat they possessed. Further studies are needed to support this possibility. The new density functions eliminate the uniform density assumption associated with some geometric models thus providing more accurate trunk segment parameter estimates. In turn, more accurate moments and forces can be estimated for the kinetic analyses of certain human movements.

Solar Eclipse-Induced Changes in the Ionosphere over the Continental US

NASA Astrophysics Data System (ADS)

Erickson, P. J.; Zhang, S.; Goncharenko, L. P.; Coster, A. J.; Hysell, D. L.; Sulzer, M. P.; Vierinen, J.

2017-12-01

For the first time in 26 years, a total solar eclipse occurred over the continental United States on 21 August 2017, between 16:00-20:00 UT. We report on American solar eclipse observations of the upper atmosphere, conducted by a team led by MIT Haystack Observatory. Efforts measured ionospheric and thermospheric eclipse perturbations. Although eclipse effects have been studied for more than 50 years, recent major sensitivity and resolution advances using radio-based techniques are providing new information on the eclipse ionosphere-thermosphere-mesosphere (ITM) system response. Our study was focused on quantifying eclipse effects on (1) traveling ionospheric disturbances (TIDs) and atmospheric gravity waves (AGWs); (2) spatial ionospheric variations associated with the eclipse; and (3) altitudinal and temporal ionospheric profile variations. We present selected early findings on ITM eclipse response including a dense global network of 6000 GNSS total electron content (TEC) receivers (100 million measurements per day; 1x1 degree spatial grid) and the Millstone Hill and Arecibo incoherent scatter radars. TEC depletions of up to 60% in magnitude were associated with the eclipse umbra and penumbra and consistently trailed the eclipse totality center. TEC enhancements associated with prominent orographic features were observed in the western US due to complex interactions as the lower atmosphere cooled in response to decreasing EUV energy inputs. Strong TIDs in the form of bow waves, stern waves, and a stern wake were observed in TEC data. Altitude-resolved plasma parameter profiles from Millstone Hill saw a nearly 50% decrease in F region electron density in vertical profiles, accompanied by a corresponding 200-250 K decrease in electron temperature. Wide field Millstone Hill radar scans showed similar decreases in electron density to the southwest, maximizing along the line of closest approach to totality. Data is available to the research community through the MIT Haystack Madrigal system. Alongside a summary of observations, we will also present preliminary quantitative comparisons with several ongoing modeling efforts.

Greek-origin royal jelly improves the lipid profile of postmenopausal women.

PubMed

Lambrinoudaki, Irene; Augoulea, Areti; Rizos, Demetrios; Politi, Marianna; Tsoltos, Nikolaos; Moros, Michail; Chinou, Ioanna; Graikou, Konstantia; Kouskouni, Evangelia; Kambani, Susana; Panoulis, Konstantinos; Moutsatsou, Paraskevi

2016-10-01

Menopause transition is associated with chronic conditions such as osteoporosis and cardiovascular disease. Concerns about the long-term safety of menopausal hormone therapy make alternative natural methods an appealing approach to management. The aim of this study was to examine the effect of royal jelly (RJ) on cardiovascular and bone turnover markers in clinically healthy postmenopausal women. A total of 36 postmenopausal healthy women were studied in a prospective follow-up study. Participants received 150 mg of RJ daily for three months. Circulating cardiovascular risk markers [lipid profile, antithrombin-III (ATIII), Protein C, Protein S, Plasminogen Activator Inhibitor-1 (PAI-1)] and bone turnover parameters [Total calcium, phosphate (P), parathormone (PTH), total type-1 Procollagen N-terminal (P1NP), Osteocalcin and serum collagen type 1 cross-linked C-telopeptide (CTX)] were compared between the baseline and the three-month visit. The RJ used in this study was particularly rich in medium chain fatty acids, compounds with hypolipidemic properties, which comprised 63% of the dry weight fatty content. RJ treatment resulted in a significant increase in high density lipoprotein - cholesterol (HDL-C 60.2 mg/dL ± 12.3 versus 64.7 mg/dL ± 13.9, 7.7% increase, p = 0.0003), as well as in a significant decrease in low density lipoprotein - cholesterol (LDL-C, 143.9 ± 37.5 versus 136.2 ± 32, 4.1% decrease, p = 0.011) and in total cholesterol (224.4 ± 38.6 to 216.1 ± 36.5, 3.09% decrease, p = 0.018). No statistical significant changes were found in the remaining cardiovascular or the bone turnover parameters. The intake of RJ 150 mg for three months is associated with significant improvements of the lipid profile of postmenopausal women. RJ supplementation may offer an alternative method of controlling the menopause - associated dyslipidemia.

Revisiting the bulge-halo conspiracy - II. Towards explaining its puzzling dependence on redshift

NASA Astrophysics Data System (ADS)

Shankar, Francesco; Sonnenfeld, Alessandro; Grylls, Philip; Zanisi, Lorenzo; Nipoti, Carlo; Chae, Kyu-Hyun; Bernardi, Mariangela; Petrillo, Carlo Enrico; Huertas-Company, Marc; Mamon, Gary A.; Buchan, Stewart

2018-04-01

We carry out a systematic investigation of the total mass density profile of massive (log Mstar/M⊙ ˜ 11.5) early-type galaxies and its dependence on redshift, specifically in the range 0 ≲ z ≲ 1. We start from a large sample of Sloan Digital Sky Survey early-type galaxies with stellar masses and effective radii measured assuming two different profiles, de Vaucouleurs and Sérsic. We assign dark matter haloes to galaxies via abundance matching relations with standard ΛCDM profiles and concentrations. We then compute the total, mass-weighted density slope at the effective radius γ΄, and study its redshift dependence at fixed stellar mass. We find that a necessary condition to induce an increasingly flatter γ΄ at higher redshifts, as suggested by current strong lensing data, is to allow the intrinsic stellar profile of massive galaxies to be Sérsic and the input Sérsic index n to vary with redshift as n(z) ∝ (1 + z)δ, with δ ≲ -1. This conclusion holds irrespective of the input Mstar-Mhalo relation, the assumed stellar initial mass function (IMF), or even the chosen level of adiabatic contraction in the model. Secondary contributors to the observed redshift evolution of γ΄ may come from an increased contribution at higher redshifts of adiabatic contraction and/or bottom-light stellar IMFs. The strong lensing selection effects we have simulated seem not to contribute to this effect. A steadily increasing Sérsic index with cosmic time is supported by independent observations, though it is not yet clear whether cosmological hierarchical models (e.g. mergers) are capable of reproducing such a fast and sharp evolution.

Evaluation of Lipid Profile Changes in Pediatric Patients with Acute Mononucleosis

PubMed Central

2017-01-01

Background Acute Epstein-Barr virus (EBV) infection could lead to atherogenic lipid profile changes in adults; while there is no evidence about the children with Infectious mononucleosis (IM). The aim of this study was to evaluate the lipid profile of the children in acute phase of mononucleosis and two months after the recovery. Materials and Methods From 2010 through 2012, 36 children with IM aged 1-10 years were enrolled in a prospective cross-sectional study. Fasting serum total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), and triglyceride level were measured during acute phase of the disease and after 2 months of the recovery. Results From 36 patients enrolled, 25 (69.4%) cases were male and the mean age of the patients was 4.1 ± 2.0 years. The mean of the total cholesterol level in the acute phase and 2 months after the recovery were149.5 ± 35.3 mg/dL and 145.7±30.6, respectively (P = 0.38). However, the serum level of HDL cholesterol in patients after 2 months of recovery was significantly increased (37.9 ± 9.3 mg/dL vs. 28.5 ± 10.6 mg/dL, P <0.001). The mean value of serum LDL cholesterol was significantly reduced, two months after recovery (81.4 ± 19.5 mg/dL, vs. 92.6 ± 28.8 mg/dL, P = 0.009). Furthermore, the serum triglyceride level was significantly reduced after the recovery (108.7 ± 36.9 mg/dL) compared with the acute phase (163.8 ± 114.3 mg/dL) (P = 0.004). Conclusion EBV infection in children could change lipid profile which is partially restored 2 months after the recovery. PMID:28332346

Dietary pattern as identified by factorial analysis and its association with lipid profile and fasting plasma glucose among Iranian individuals with spinal cord injury.

PubMed

Sabour, Hadis; Soltani, Zahra; Latifi, Sahar; Javidan, Abbas Norouzi

2016-07-01

Plasma lipids (triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C)) may be associated with dietary intakes. The purpose of this study was to identify the most common food patterns among Iranian persons with spinal cord injury (SCI) and investigate their associations with lipid profile. Cross-sectional. Tertiary rehabilitation center. Referred individuals to Brain and Spinal Injury Research Center (BASIR) from 2011 to 2014. Dietary intakes were assessed by 24-hour dietary recall interviews in three non-consecutive days. Principal component analysis (PCA) was used to identify dietary patterns. Total of 100 persons (83 male and 17 female) entered the study. Four food patterns were detected. The most common dietary pattern (Pattern 1) included processed meat, sweets desserts and soft drink and was similar to 'Western' food pattern described previously. Pattern 1 was related to higher levels of TC and LDL-C (r = 0.09; P = 0.04 and r = 0.11; P = 0.03 for TC and LDL-C, respectively) only in male participants. Pattern 2 which included tea, nuts, vegetable oil and sugars had a positive association with TC level (r = 0.11; P = 0.02) again in male participants. Pattern 3 which represented a healthy food pattern showed no significant influence on lipid profiles. In this study, the four most common dietary patterns among Iranian individuals with SCI have been identified. Western food pattern was the most common diet and was associated with increased TC and LDL-C. The healthy food pattern, in which the major source of calories was protein, was not associated with variance in lipid profile.

A Phytosterol-Enriched Spread Improves Lipid Profile and Insulin Resistance of Women with Gestational Diabetes Mellitus: A Randomized, Placebo-Controlled Double-Blind Clinical Trial.

PubMed

Li, Qin; Xing, Baoheng

2016-08-01

Gestational diabetes mellitus (GDM) has become a serious health risk among pregnant women throughout the world. Phytosterol-enriched margarines are capable of lowering total cholesterol (TC) and low-density lipoprotein (LDL), but little is known about its effects on GDM. We aimed to examine the effects of daily consumption of a phytosterol-enriched spread on insulin resistance and lipid profile in pregnant GDM women. Pregnant women suffering from GDM in their second trimester were recruited and randomly assigned to consume a margarine spread either with or without phytosterols daily for 16 weeks. Serum lipid profile and glucose and insulin metabolisms were assessed at week 0 (baseline) and week 16 (end of trial). After 16 weeks, levels of triacylglycerol, TC, and LDL were significantly decreased, while high-density lipoprotein was significantly increased, compared with the baseline in the phytosterol group. In addition, in the same treatment group, glucose metabolic parameters, including fasting plasma glucose, serum insulin levels, the quantitative insulin check index, homeostasis model of assessment of insulin resistance, and β-cell function, were also significantly improved. Daily consumption of a phytosterol-enriched spread improved insulin resistance and lipid profile in women with GDM.

Measurements of Electron Density Profiles of Plasmas Produced by Nike KrF Laser for Laser Plasma Instability (LPI) Research

NASA Astrophysics Data System (ADS)

Oh, Jaechul; Weaver, J. L.; Obenschain, S. P.; Schmitt, A. J.; Kehne, D. M.; Karasik, M.; Chan, L.-Y.; Serlin, V.; Phillips, L.

2013-10-01

Knowing spatial profiles of electron density (ne) in the underdense coronal region (n

Effect of short-term hypoxia on marine nematode community structure and vertical distribution pattern in three different sediment types of the North Sea.

PubMed

Taheri, Mehrshad; Braeckman, Ulrike; Vincx, Magda; Vanaverbeke, Jan

2014-08-01

The responses of nematode communities to short-term hypoxia (1 and 7 days) were investigated in three North Sea stations with different sediment types (coarse silt, fine sand and medium sand). In the field, nematode density, diversity, vertical distribution and community structure differ among the stations. In the laboratory, oxic and hypoxic treatments were established for 1 and 7 days for all sediment types. Comparison between field control and oxic day 1 treatments showed that experimental sediment handling did not affect nematode characteristics. Our results revealed that short-term hypoxia did not affect total density, diversity, community composition, vertical density profiles (except in the fine sand) and densities of five dominant species in all sediment types. Copyright © 2014 Elsevier Ltd. All rights reserved.

Generalized skew-symmetric interfacial probability distribution in reflectivity and small-angle scattering analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jiang, Zhang; Chen, Wei

Generalized skew-symmetric probability density functions are proposed to model asymmetric interfacial density distributions for the parameterization of any arbitrary density profiles in the `effective-density model'. The penetration of the densities into adjacent layers can be selectively controlled and parameterized. A continuous density profile is generated and discretized into many independent slices of very thin thickness with constant density values and sharp interfaces. The discretized profile can be used to calculate reflectivities via Parratt's recursive formula, or small-angle scattering via the concentric onion model that is also developed in this work.

Generalized skew-symmetric interfacial probability distribution in reflectivity and small-angle scattering analysis

DOE PAGES

Jiang, Zhang; Chen, Wei

2017-11-03

Generalized skew-symmetric probability density functions are proposed to model asymmetric interfacial density distributions for the parameterization of any arbitrary density profiles in the `effective-density model'. The penetration of the densities into adjacent layers can be selectively controlled and parameterized. A continuous density profile is generated and discretized into many independent slices of very thin thickness with constant density values and sharp interfaces. The discretized profile can be used to calculate reflectivities via Parratt's recursive formula, or small-angle scattering via the concentric onion model that is also developed in this work.

Plasma lipid levels of rats fed a diet containing pork fat as a source of lipids after splenic surgery.

PubMed

Dinis, Ana Paula Gonçalves; Marques, Ruy Garcia; Simões, Fernanda Correia; Diestel, Cristina Fajardo; Caetano, Carlos Eduardo Rodrigues; Secchin, Dióscuro José Ferreira; Neto, José Firmino Nogueira; Portela, Margareth Crisóstomo

2009-06-01

Experimental studies have suggested an important role of the spleen in lipid metabolism, although with controversial results. Our purpose was to analyze the effect of a nutritionally balanced (NB) diet and a diet containing pork fat (PF) as source of lipids on the lipid profile of rats submitted to splenic surgery. Sixty adult male Wistar rats were divided into six groups of 10 animals each: 1 sham-operated, NB diet; 2 sham-operated, PF diet; 3 total splenectomy (TS), NB diet; 4 TS, PF diet; 5 TS followed by splenic autotransplantation (SA), NB diet; and 6 SA, PF diet. Blood samples were collected at the beginning (D0) and after 12 weeks of the experiment (D + 12) for plasma lipid determination. Morphologic regeneration of splenic tissues was observed, with no differences between groups 5 and 6. When D + 12 plasma lipid levels were compared to D0 levels there were no differences in groups 1, 3, and 5, while in groups 2, 4, and 6 total cholesterol (TC), low density lipoprotein (LDL), very low density lipoprotein (VLDL), and triacylglycerols (TAG) increased, and high density lipoprotein (HDL) decreased. At D + 12, groups 2, 4, and 6 had lower HDL than group 3. In conclusion, regardless of the surgical procedure applied to the spleen, an NB diet maintained plasma lipid levels while a diet with PF as source of lipids changed the animals' lipid profile.

Full-wave reflection of lightning long-wave radio pulses from the ionospheric D region: Comparison with midday observations of broadband lightning signals

NASA Astrophysics Data System (ADS)

Jacobson, Abram R.; Shao, Xuan-Min; Holzworth, Robert

2010-05-01

We are developing and testing a steep-incidence D region sounding method for inferring profile information, principally regarding electron density. The method uses lightning emissions (in the band 5-500 kHz) as the probe signal. The data are interpreted by comparison against a newly developed single-reflection model of the radio wave's encounter with the lower ionosphere. The ultimate application of the method will be to study transient, localized disturbances of the nocturnal D region, including those instigated by lightning itself. Prior to applying the method to study lightning-induced perturbations of the nighttime D region, we have performed a validation test against more stable and predictable daytime observations, where the profile of electron density is largely determined by direct solar X-ray illumination. This article reports on the validation test. Predictions from our recently developed full-wave ionospheric-reflection model are compared to statistical summaries of daytime lightning radiated waveforms, recorded by the Los Alamos Sferic Array. The comparison is used to retrieve best fit parameters for an exponential profile of electron density in the ionospheric D region. The optimum parameter values are compared to those found elsewhere using a narrowband beacon technique, which used totally different measurements, ranges, and modeling approaches from those of the work reported here.

Association between markers of systemic inflammation, oxidative stress, lipid profiles, and insulin resistance in pregnant women.

PubMed

Asemi, Zatollah; Jazayeri, Shima; Najafi, Mohammad; Samimi, Mansooreh; Shidfar, Farzad; Tabassi, Zohreh; Shahaboddin, Mohamadesmaeil; Esmaillzadeh, Ahmad

2013-05-01

Increased levels of pro-inflammatory factors, markers of oxidative stress and lipid profiles are known to be associated with several complications. The aim of this study was to determine the association of markers of systemic inflammation, oxidative stress and lipid profiles with insulin resistance in pregnant women in Kashan, Iran. In a cross-sectional study, serum high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), fasting plasma glucose (FPG), serum insulin, 8-oxo-7, 8-dihydroguanine (8-oxo-G), total cholesterol, triglyceride, High density lipoprotein-cholesterol (HDL-cholesterol), and plasma total antioxidant capacity (TAC) were measured among 89 primigravida singleton pregnant women aged 18-30 years at 24-28 weeks of gestation. Pearson's correlation and multiple linear regressions were used to assess their relationships with homeostatic model assessment of insulin resistance (HOMA-IR). We found that among biochemical indicators of pregnant women, serum hs-CRP and total cholesterol levels were positively correlated with HOMA-IR (β = 0.05, P = 0.006 for hs-CRP and β = 0.006, P = 0.006 for total cholesterol). These associations remained significant even after mutual effect of other biochemical indicators were controlled (β = 0.04, P = 0.01 for hs-CRP and β = 0.007, P = 0.02 for total cholesterol). Further adjustment for body mass index made the association of hs-CRP and HOMA-IR disappeared; however, the relationship for total cholesterol remained statistically significant. Our findings showed that serum total cholesterol is independently correlated with HOMA-IR score. Further studies are needed to confirm our findings.

Non-stationary self-focusing of intense laser beam in plasma using ramp density profile

DOE Office of Scientific and Technical Information (OSTI.GOV)

Habibi, M.; Ghamari, F.

2011-10-15

The non-stationary self-focusing of high intense laser beam in under-dense plasma with upward increasing density ramp is investigated. The obtained results show that slowly increasing plasma density ramp is very important in enhancing laser self-focusing. Also, the spot size oscillations of laser beam in front and rear of the pulse for two different density profiles are shown. We have selected density profiles that already were used by Sadighi-Bonabi et al.[Phys. Plasmas 16, 083105 (2009)]. Ramp density profile causes the laser beam to become more focused and penetrations deeps into the plasma by reduction of diffraction effects. Our computations show moremore » reliable results in comparison to the previous works.« less

Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study.

PubMed

Vazquez-Vidal, Itzel; Voruganti, V Saroja; Hannon, Bridget A; Andrade, Flavia Cristina Drumond; Aradillas-García, Celia; Nakamura, Manabu T; Terán-García, Margarita

2018-05-30

Recent genome-wide association studies in the Mexican population have identified several genetic loci associated with blood lipid levels in adults. However, studies focusing on the fatty acid desaturase (FADS) gene cluster have been understudied in this population, even though it seems associated with lipid profiles in other ethnicities. The aim of this study was to test associations between single nucleotide polymorphisms (SNPs) in the FADS cluster (rs174546, rs1535, rs174548, rs174550, rs174450, and rs174618) and serum lipid profiles in young Mexicans. Anthropometrics, serum lipid profiles, and FADS SNPs were measured in 998 subjects in the UP-AMIGOS cohort study. Genotype-phenotype (total cholesterol [TC], triglyceride [TG], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], and very-low-density lipoprotein [VLDL]) associations were assessed using PLINK adjusted for sex, age, and body mass index (BMI). Among 6 FADS SNPs, we found that carriers of the C-allele of the FADS1-rs174546 showed a significant association with lower TG concentrations (β = -12.6 mg/dL, p = 0.009) and lower VLDL concentrations (β = -2.52 mg/dL, p = 0.005). We found that rs174546, rs1535, and rs174550 were in high linkage disequilibrium (r2 > 0.80). There were no significant associations between rs174550, rs174548, and rs174618 and lipid profiles. A genetic variant in the FADS1 (rs174546) gene is a major contributor of plasma TG and VLDL concentrations in healthy young Mexicans. © 2018 S. Karger AG, Basel.

Seasonal mercury exposure and oxidant-antioxidant status of James Bay sport fishermen.

PubMed

Bélanger, Marie-Claire; Mirault, Marc-Edouard; Dewailly, Eric; Plante, Michel; Berthiaume, Line; Noël, Micheline; Julien, Pierre

2008-05-01

The effects of a moderate seasonal exposure to methylmercury on plasma low-density lipoprotein (LDL) oxidation and cardiovascular risk indices are not known. The objective of the study was to assess the effects of a seasonal exposure to mercury at similar dose reported to increase cardiovascular risk through fish consumption. Effects on lipoprotein cholesterol and fatty acid profiles, LDL oxidation, and blood oxidant-antioxidant balance were to be assessed in sport fishermen presenting normal blood selenium and omega-3 fatty acid contents. Thirty-one healthy James Bay sport fishermen were assessed for within-subject longitudinal seasonal variations in hair and blood mercury, plasma oxidized LDL, lipophilic antioxidants, homocysteine, blood selenium, and glutathione peroxidase and reductase activities determined before and after the fishing season and compared by matched-pair tests. Hair mercury doubled during the fishing season (2.8+/-0.4 microg/g, P<.0001). Baseline blood selenium, homocysteine, and erythrocyte fatty acid profiles did not change. Plasma high-density lipoprotein cholesterol increased (+5%, P=.05), whereas very low-density lipoprotein cholesterol and oxidized LDL decreased (-8%, P=.05; -18%, P=.008). Blood glutathione peroxidase (+9.7%, P=.001), glutathione reductase (+7.2%, P<.0001), and total glutathione (+45% P<.0001) increased during the fishing season. Plasma total coenzyme Q10 (+13%, P=.02), ubiquinone-10 (+67%, P=.03), and beta-carotene (+46%, P=.01) also increased, whereas vitamin E status was unaffected. Pairwise correlations revealed no association between mercury exposure and any of the biomarkers investigated. In contrast, strong predictors of cardiovascular risk such as high-density lipoprotein cholesterol, oxidized LDL, and glutathione peroxidase improved during the fishing season despite elevated methylmercury exposure. The beneficial effects of seasonal fishing activity and fish consumption on cardiovascular health may suppress detrimental effects of concomitant moderate methylmercury exposure.

The MASSIVE survey - VIII. Stellar velocity dispersion profiles and environmental dependence of early-type galaxies

NASA Astrophysics Data System (ADS)

Veale, Melanie; Ma, Chung-Pei; Greene, Jenny E.; Thomas, Jens; Blakeslee, John P.; Walsh, Jonelle L.; Ito, Jennifer

2018-02-01

We measure the radial profiles of the stellar velocity dispersions, σ(R), for 90 early-type galaxies (ETGs) in the MASSIVE survey, a volume-limited integral-field spectroscopic (IFS) galaxy survey targeting all northern-sky ETGs with absolute K-band magnitude MK < -25.3 mag, or stellar mass M* ≳ 4 × 1011M⊙, within 108 Mpc. Our wide-field 107 arcsec × 107 arcsec IFS data cover radii as large as 40 kpc, for which we quantify separately the inner (2 kpc) and outer (20 kpc) logarithmic slopes γinner and γouter of σ(R). While γinner is mostly negative, of the 56 galaxies with sufficient radial coverage to determine γouter we find 36 per cent to have rising outer dispersion profiles, 30 per cent to be flat within the uncertainties and 34 per cent to be falling. The fraction of galaxies with rising outer profiles increases with M* and in denser galaxy environment, with 10 of the 11 most massive galaxies in our sample having flat or rising dispersion profiles. The strongest environmental correlations are with local density and halo mass, but a weaker correlation with large-scale density also exists. The average γouter is similar for brightest group galaxies, satellites and isolated galaxies in our sample. We find a clear positive correlation between the gradients of the outer dispersion profile and the gradients of the velocity kurtosis h4. Altogether, our kinematic results suggest that the increasing fraction of rising dispersion profiles in the most massive ETGs are caused (at least in part) by variations in the total mass profiles rather than in the velocity anisotropy alone.

Purely Dry Mergers do not Explain the Observed Evolution of Massive Early-type Galaxies since z ~ 1

NASA Astrophysics Data System (ADS)

Sonnenfeld, Alessandro; Nipoti, Carlo; Treu, Tommaso

2014-05-01

Several studies have suggested that the observed size evolution of massive early-type galaxies (ETGs) can be explained as a combination of dry mergers and progenitor bias, at least since z ~ 1. In this paper we carry out a new test of the dry-merger scenario based on recent lensing measurements of the evolution of the mass density profile of ETGs. We construct a theoretical model for the joint evolution of the size and mass density profile slope γ' driven by dry mergers occurring at rates given by cosmological simulations. Such dry-merger model predicts a strong decrease of γ' with cosmic time, inconsistent with the almost constant γ' inferred from observations in the redshift range 0 < z < 1. We then show with a simple toy model that a modest amount of cold gas in the mergers—consistent with the upper limits on recent star formation in ETGs—is sufficient to reconcile the model with measurements of γ'. By fitting for the amount of gas accreted during mergers, we find that models with dissipation are consistent with observations of the evolution in both size and density slope, if ~4% of the total final stellar mass arises from the gas accreted since z ~ 1. Purely dry merger models are ruled out at >99% CL. We thus suggest a scenario where the outer regions of massive ETGs grow by accretion of stars and dark matter, while small amounts of dissipation and nuclear star formation conspire to keep the mass density profile constant and approximately isothermal.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garnier, D. T.; Mauel, M. E.; Roberts, T. M.

Here, we report measurements of the turbulent evolution of the plasma density profile following the fast injection of lithium pellets into the Levitated Dipole Experiment (LDX) [Boxer et al., Nat. Phys. 6, 207 (2010)]. As the pellet passes through the plasma, it provides a significant internal particle source and allows investigation of density profile evolution, turbulent relaxation, and turbulent fluctuations. The total electron number within the dipole plasma torus increases by more than a factor of three, and the central density increases by more than a factor of five. During these large changes in density, the shape of the densitymore » profile is nearly “stationary” such that the gradient of the particle number within tubes of equal magnetic flux vanishes. In comparison to the usual case, when the particle source is neutral gas at the plasma edge, the internal source from the pellet causes the toroidal phase velocity of the fluctuations to reverse and changes the average particle flux at the plasma edge. An edge particle source creates an inward turbulent pinch, but an internal particle source increases the outward turbulent particle flux. Statistical properties of the turbulence are measured by multiple microwave interferometers and by an array of probes at the edge. The spatial structures of the largest amplitude modes have long radial and toroidal wavelengths. Estimates of the local and toroidally averaged turbulent particle flux show intermittency and a non-Gaussian probability distribution function. The measured fluctuations, both before and during pellet injection, have frequency and wave number dispersion consistent with theoretical expectations for interchange and entropy modes excited within a dipole plasma torus having warm electrons and cool ions.« less

Effects of CO[sub 2] and climate change on forest trees: Soil biology and enzymology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moldenke, A.R.; Baumeister, N.; Caldwell, B.A.

1994-06-01

Samples of Teracosm soils were analyzed shortly after initial setup to determine whether initial conditions were equivalent and matched expected values for local soils. Total and active fungal biomass, active bacterial biomass and protozoan numbers were reduced, with greatest decreases occurring in the A horizon. No effect was observed on total bacterial biomass, nematode or anthropod densities, but changes in nematode and arthropod species composition occurred. Significant differences in total density and species composition occurred between the enclosed Teracosms and the open controls. Arthropod and nematode community structure in the three altitudinal field sites had significantly diverged. No significant differencesmore » in activities of key soil enzymes in C- and N-cycling (acid phosphatase, protease, B-glucosidase, phenol oxidase and peroxidase) were found between initial samples relative to treatment, but all levels were significantly difference relative to depth in soil profile. Activities were within ranges previously observed in forests of the Pacific Northwest.« less

Cardiovascular risk profile in burn survivors.

PubMed

Leung, Becky; Younger, John F; Stockton, Kellie; Muller, Michael; Paratz, Jennifer

2017-11-01

Burn patients have prolonged derangements in metabolic, endocrine, cardiac and psychosocial systems, potentially impacting on their cardiovascular health. There are no studies on the risk of cardiovascular disease (CVD) after-burn. The aim of our study was to record lipid values and evaluate CVD risk in adult burn survivors. In a cross-sectional study patients ≥18 years with burn injury between 18-80% total burn surface area (TBSA) from 1998 to 2012 had total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL) and triglycerides measured via finger prick. Means were compared to optimal ranges. Multivariate regression models were performed to assess the association of lipids with age, years after-burn and total body surface area % (TBSA). A p value <0.05 was considered significant. The Framingham General Cardiovascular Risk Score (FGCRS) was calculated. Fifty patients were included in the study. Compared to optimal values, patients had low HDL and high triglycerides. Greater %TBSA was associated with statistically significant elevation of triglycerides (p=0.007) and total cholesterol/HDL ratio (p=0.027). The median FGCRS was 3.9% (low) 10-year risk of CVD with 82% of patients in the low-risk category. Patients involved in medium/high level of physical activity had optimal values of HDL, TC/HDL and triglycerides despite the magnitude of TBSA%. Adult burn survivors had alterations in lipid profile proportional to TBSA, which could be modified by exercise, and no increase in overall formally predicted CVD risk in this cross sectional study. Copyright © 2017 Elsevier Ltd and ISBI. All rights reserved.

Variation in sensitivity, absorption and density of the central rod distribution with eccentricity.

PubMed

Tornow, R P; Stilling, R

1998-01-01

To assess the human rod photopigment distribution and sensitivity with high spatial resolution within the central +/-15 degrees and to compare the results of pigment absorption, sensitivity and rod density distribution (number of rods per square degree). Rod photopigment density distribution was measured with imaging densitometry using a modified Rodenstock scanning laser ophthalmoscope. Dark-adapted sensitivity profiles were measured with green stimuli (17' arc diameter, 1 degrees spacing) using a T ubingen manual perimeter. Sensitivity profiles were plotted on a linear scale and rod photopigment optical density distribution profiles were converted to absorption profiles of the rod photopigment layer. Both the absorption profile of the rod photopigment and the linear sensitivity profile for green stimuli show a minimum at the foveal center and increase steeply with eccentricity. The variation with eccentricity corresponds to the rod density distribution. Rod photopigment absorption profiles, retinal sensitivity profiles, and the rod density distribution are linearly related within the central +/-15 degrees. This is in agreement with theoretical considerations. Both methods, imaging retinal densitometry using a scanning laser ophthalmoscope and dark-adapted perimetry with small green stimuli, are useful for assessing the central rod distribution and sensitivity. However, at present, both methods have limitations. Suggestions for improving the reliability of both methods are given.

Effects of probiotic supplementation in different nutrient density diets on growth performance, nutrient digestibility, blood profiles, fecal microflora and noxious gas emission in weaning pig.

PubMed

Lan, Ruixia; Tran, Hoainam; Kim, Inho

2017-03-01

Probiotics can serve as alternatives to antibiotics to increase the performance of weaning pigs, and the intake of probiotics is affected by dietary nutrient density. The objective of this study was to evaluate the effects of a probiotic complex in different nutrient density diets on growth performance, digestibility, blood profiles, fecal microflora and noxious gas emission in weaning pigs. From day 22 to day 42, both high-nutrient-density and probiotic complex supplementation diets increased (P < 0.05) the average daily gain. On day 42, the apparent total tract digestibility (ATTD) of dry matter, nitrogen and gross energy (GE), blood urea nitrogen concentration and NH 3 and H 2 S emissions were increased (P < 0.05) in pigs fed high-nutrient-density diets. Pigs fed probiotic complex supplementation diets had higher (P < 0.05) ATTD of GE than pigs fed non-supplemented diets. Fecal Lactobacillus counts were increased whereas Escherichia coli counts and NH 3 and H 2 S emissions were decreased (P < 0.05) in pigs fed probiotic complex supplementation diets. Interactive effects on average daily feed intake (ADFI) were observed from day 22 to day 42 and overall, where probiotic complex improved ADFI more dramatically in low-nutrient-density diets. The beneficial effects of probiotic complex (Bacillus coagulans, Bacillus licheniformis, Bacillus subtilis and Clostridium butyricum) supplementation on ADFI is more dramatic with low-nutrient-density diets. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

The cosmological dependence of cluster density profiles

NASA Technical Reports Server (NTRS)

Crone, Mary M.; Evrard, August E.; Richstone, Douglas O.

1994-01-01

We use N-body simulations to study the shape of mean cluster density and velocity profiles in the nonlinear regime formed via gravitational instability. The dependence of the final structure on both cosmology and initial density field is examined, using a grid of cosmologies and scale-free initial power spectra P(k) varies as k(exp n). Einstein-de Sitter, open (Omega(sub 0) = 0.2 and 0.1) and flat, low density (Omega(sub 0) = 0.2 lambda(sub 0) = 0.8) models are examined, with initial spectral indices n = -2, -1 and 0. For each model, we stack clusters in an appropriately scaled manner to define an average density profile in the nonlinear regime. The profiles are well fit by a power law rho(r) varies as r(exp -alpha) for radii whereat the local density contrast is between 100 and 3000. This covers 99% of the cluster volume. We find a clear trend toward steeper slopes (larger alphas) with both increasing n and decreasing Omega(sub 0). The Omega(sub 0) dependence is partially masked by the n dependence; there is degeneracy in the values of alpha between the Einstein-de Sitter and flat, low-density cosmologies. However, the profile slopes in the open models are consistently higher than the Omega = 1 values for the range of n examined. Cluster density profiles are thus potentially useful cosmological diagnostics. We find no evidence for a constant density core in any of the models, although the density profiles do tend to flatten at small radii. Much of the flattening is due to the force softening required by the simulations. An attempt is made to recover the unsoftened profiles assuming angular momentum invariance. The recovered profiles in Einstein-de Sitter cosmologies are consistent with a pure power law up to the highest density contrasts (10(exp 6)) accessible with our resolution. The low-density models show significant deviation from a power law above density contrasts approximately 10(exp 5). We interpret this curvature as reflecting the non-scale-invariant nature of the background cosmology in these models. These results are at the limit of our resolution and so should be tested in the future using simulations with larger numbers of particles. Such simulations will also provide insight on the broader problem of understanding, in a statistical sense, the full phase space structure of collapsed, cosmological halos.

The dayside ionospheres of Mars and Venus: Comparing a one-dimensional photochemical model with MaRS (Mars Express) and VeRa (Venus Express) observations

NASA Astrophysics Data System (ADS)

Peter, Kerstin; Pätzold, Martin; Molina-Cuberos, Gregorio; Witasse, Olivier; González-Galindo, F.; Withers, Paul; Bird, Michael K.; Häusler, Bernd; Hinson, David P.; Tellmann, Silvia; Tyler, G. Leonard

2014-05-01

The electron density distributions of the lower ionospheres of Mars and Venus are mainly dependent on the solar X-ray and EUV flux and the solar zenith angle. The influence of an increasing solar flux is clearly seen in the increase of the observed peak electron density and total electron content (TEC) of the main ionospheric layers. The model “Ionization in Atmospheres” (IonA) was developed to compare ionospheric radio sounding observations, which were performed with the radio science experiments MaRS on Mars Express and VeRa on Venus Express, with simulated electron density profiles of the Mars and Venus ionospheres. This was done for actual observation conditions (solar flux, solar zenith angle, planetary coordinates) from the bases of the ionospheres to ∼160 km altitude. IonA uses models of the neutral atmospheres at ionospheric altitudes (Mars Climate Database (MCD) v4.3 for Mars; VenusGRAM/VIRA for Venus) and solar flux information in the 0.5-95 nm wavelength range (X-ray to EUV) from the SOLAR2000 data base. The comparison between the observed electron density profiles and the IonA profiles for Mars, simulated for a selected MCD scenario (background atmosphere), shows that the general behavior of the Mars ionosphere is reproduced by all scenarios. The MCD “low solar flux/clear atmosphere” and “low solar flux/MY24” scenarios agree best (on average) with the MaRS set of observations, although the actual Mars atmosphere seemed to be still slightly colder at ionospheric altitudes. For Venus, the VenusGRAM model, based on VIRA, is too limited to be used for the IonA simulation of electron density profiles. The behavior of the V2 peak electron density and TEC as a function of solar zenith angle are in general reproduced, but the peak densities and the TEC are either over- or underestimated for low or high solar EUV fluxes, respectively. The simulated V2 peak altitudes are systematically underestimated by 5 km on average for solar zenith angles less than 45° and the peak altitudes rise for zenith angles larger than 60°. The latter is the opposite of the observed behavior. The explanation is that VIRA and VenusGRAM are valid only for high solar activity, although there is also very poor agreement with VeRa observations from the recent solar cycle, in which the solar activity increases to high values. The disagreement between the observation and simulation of the Venus electron density profiles proves, that the true encountered Venus atmosphere at ionospheric altitudes was denser but locally cooler than predicted by VIRA.

Streaked x-ray backlighting with twin-slit imager for study of density profile and trajectory of low-density foam target filled with deuterium liquid

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shiraga, H.; Mahigashi, N.; Yamada, T.

2008-10-15

Low-density plastic foam filled with liquid deuterium is one of the candidates for inertial fusion target. Density profile and trajectory of 527 nm laser-irradiated planer foam-deuterium target in the acceleration phase were observed with streaked side-on x-ray backlighting. An x-ray imager employing twin slits coupled to an x-ray streak camera was used to simultaneously observe three images of the target: self-emission from the target, x-ray backlighter profile, and the backlit target. The experimentally obtained density profile and trajectory were in good agreement with predictions by one-dimensional hydrodynamic simulation code ILESTA-1D.

Earliest phases of star formation (EPoS). Dust temperature distributions in isolated starless cores

NASA Astrophysics Data System (ADS)

Lippok, N.; Launhardt, R.; Henning, Th.; Balog, Z.; Beuther, H.; Kainulainen, J.; Krause, O.; Linz, H.; Nielbock, M.; Ragan, S. E.; Robitaille, T. P.; Sadavoy, S. I.; Schmiedeke, A.

2016-07-01

Context. Stars form by the gravitational collapse of cold and dense molecular cloud cores. Constraining the temperature and density structure of such cores is fundamental for understanding the initial conditions of star formation. We use Herschel observations of the thermal far-infrared (FIR) dust emission from nearby and isolated molecular cloud cores and combine them with ground-based submillimeter continuum data to derive observational constraints on their temperature and density structure. Aims: The aim of this study is to verify the validity of a ray-tracing inversion technique developed to derive the dust temperature and density structure of nearby and isolated starless cores directly from the dust emission maps and to test if the resulting temperature and density profiles are consistent with physical models. Methods: We have developed a ray-tracing inversion technique that can be used to derive the temperature and density structure of starless cores directly from the observed dust emission maps without the need to make assumptions about the physical conditions. Using this ray-tracing inversion technique, we derive the dust temperature and density structure of six isolated starless molecular cloud cores from dust emission maps in the wavelengths range 100 μm-1.2 mm. We then employ self-consistent radiative transfer modeling to the density profiles derived with the ray-tracing inversion method. In this model, the interstellar radiation field (ISRF) is the only heating source. The local strength of the ISRF as well as the total extinction provided by the outer envelope are treated as semi-free parameters which we scale within defined limits. The best-fit values of both parameters are derived by comparing the self-consistently calculated temperature profiles with those derived by the ray-tracing method. Results: We confirm earlier results and show that all starless cores are significantly colder inside than outside, with central core temperatures in the range 7.5-11.9 K and envelope temperatures that are 2.4 - 9.6 K higher. The core temperatures show a strong negative correlation with peak column density which suggests that the thermal structure of the cores is dominated by external heating from the ISRF and shielding by dusty envelopes. We find that temperature profiles derived with the ray-tracing inversion method can be well-reproduced with self-consistent radiative transfer models if the cores have geometry that is not too complex and good data coverage with spatially resolved maps at five or more wavelengths in range between 100 μm and 1.2 mm. We also confirm results from earlier studies that found that the usually adopted canonical value of the total strength of the ISRF in the solar neighbourhood is incompatible with the most widely used dust opacity models for dense cores. However, with the data available for this study, we cannot uniquely resolve the degeneracy between dust opacity law and strength of the ISRF. Final T maps (FITS format) are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/cgi-bin/qcat?J/A+A/592/A61

Horse meat consumption affects iron status, lipid profile and fatty acid composition of red blood cells in healthy volunteers.

PubMed

Del Bó, Cristian; Simonetti, Paolo; Gardana, Claudio; Riso, Patrizia; Lucchini, Giorgio; Ciappellano, Salvatore

2013-03-01

This study investigated the effect of moderate consumption of horse meat on iron status, lipid profile and fatty acid composition of red blood cells in healthy male volunteers. Fifty-two subjects were randomly assigned to two groups of 26 subjects each: a test group consuming two portions of 175 g/week of horse meat, and a control group that abstained from eating horse meat during the 90 days trial. Before and after 90 days, blood samples were collected for analysis. Horse meat consumption significantly (p ≤ 0.05) reduced serum levels of total and low-density lipoprotein cholesterol ( - 6.2% and - 9.1%, respectively) and transferrin ( - 4.6%). Total n - 3, long chain polyunsaturated fatty acids n - 3 and docosahexeanoic acid content in erythrocytes increased (p ≤ 0.05) by about 7.8%, 8% and 11%, respectively. In conclusion, the regular consumption of horse meat may contribute to the dietary intake of n - 3 polyunsaturated fatty acids and may improve lipid profile and iron status in healthy subjects.

Einasto profiles and the dark matter power spectrum

NASA Astrophysics Data System (ADS)

Ludlow, Aaron D.; Angulo, Raúl E.

2017-02-01

We study the mass accretion histories (MAHs) and density profiles of dark matter haloes using N-body simulations of self-similar gravitational clustering from scale-free power spectra, P(k) ∝ kn. We pay particular attention to the density profile curvature, which we characterize using the shape parameter, α, of an Einasto profile. In agreement with previous findings, our results suggest that, despite vast differences in their MAHs, the density profiles of virialized haloes are remarkably alike. Nonetheless, clear departures from self-similarity are evident: For a given spectral index, α increases slightly but systematically with `peak height', ν ≡ δsc/σ(M, z), regardless of mass or redshift. More importantly, however, the `α-ν' relation depends on n: The steeper the initial power spectrum, the more gradual the curvature of both the mean MAHs and mean density profiles. These results are consistent with previous findings connecting the shapes of halo mass profiles and MAHs, and imply that dark matter haloes are not structurally self-similar but, through the merger history, retain a memory of the linear density field from which they form.

Neural network evaluation of reflectometry density profiles for control purposes

NASA Astrophysics Data System (ADS)

Santos, J.; Nunes, F.; Manso, M.; Nunes, I.

1999-01-01

Broadband reflectometry is a diagnostic that is able to measure the density profile with high spatial and temporal resolutions, therefore it can be used to improve the performance of advanced tokamak operation modes and to supplement or correct the magnetics for plasma position control. To perform these tasks real-time processing is needed. Here we present a method that uses a neural network to make a fast evaluation of radial positions for selected density layers. Typical ASDEX Upgrade density profiles were used to generate the simulated network training and test sets. It is shown that the method has the potential to meet the tight timing requirements of control applications with the required accuracy. The network is also able to provide an accurate estimation of the position of density layers below the first density layer which is probed by an O-mode reflectometer, provided that it is trained with a realistic density profile model.

Signal optimization in urban transport: A totally asymmetric simple exclusion process with traffic lights.

PubMed

Arita, Chikashi; Foulaadvand, M Ebrahim; Santen, Ludger

2017-03-01

We consider the exclusion process on a ring with time-dependent defective bonds at which the hopping rate periodically switches between zero and one. This system models main roads in city traffics, intersecting with perpendicular streets. We explore basic properties of the system, in particular dependence of the vehicular flow on the parameters of signalization as well as the system size and the car density. We investigate various types of the spatial distribution of the vehicular density, and show existence of a shock profile. We also measure waiting time behind traffic lights, and examine its relationship with the traffic flow.

Signal optimization in urban transport: A totally asymmetric simple exclusion process with traffic lights

NASA Astrophysics Data System (ADS)

Arita, Chikashi; Foulaadvand, M. Ebrahim; Santen, Ludger

2017-03-01

We consider the exclusion process on a ring with time-dependent defective bonds at which the hopping rate periodically switches between zero and one. This system models main roads in city traffics, intersecting with perpendicular streets. We explore basic properties of the system, in particular dependence of the vehicular flow on the parameters of signalization as well as the system size and the car density. We investigate various types of the spatial distribution of the vehicular density, and show existence of a shock profile. We also measure waiting time behind traffic lights, and examine its relationship with the traffic flow.

Universal analytical scattering form factor for shell-, core-shell, or homogeneous particles with continuously variable density profile shape.

PubMed

Foster, Tobias

2011-09-01

A novel analytical and continuous density distribution function with a widely variable shape is reported and used to derive an analytical scattering form factor that allows us to universally describe the scattering from particles with the radial density profile of homogeneous spheres, shells, or core-shell particles. Composed by the sum of two Fermi-Dirac distribution functions, the shape of the density profile can be altered continuously from step-like via Gaussian-like or parabolic to asymptotically hyperbolic by varying a single "shape parameter", d. Using this density profile, the scattering form factor can be calculated numerically. An analytical form factor can be derived using an approximate expression for the original Fermi-Dirac distribution function. This approximation is accurate for sufficiently small rescaled shape parameters, d/R (R being the particle radius), up to values of d/R ≈ 0.1, and thus captures step-like, Gaussian-like, and parabolic as well as asymptotically hyperbolic profile shapes. It is expected that this form factor is particularly useful in a model-dependent analysis of small-angle scattering data since the applied continuous and analytical function for the particle density profile can be compared directly with the density profile extracted from the data by model-free approaches like the generalized inverse Fourier transform method. © 2011 American Chemical Society

The JCMT Nearby Galaxies Legacy Survey - XI. Environmental variations in the atomic and molecular gas radial profiles of nearby spiral galaxies

NASA Astrophysics Data System (ADS)

Mok, Angus; Wilson, C. D.; Knapen, J. H.; Sánchez-Gallego, J. R.; Brinks, E.; Rosolowsky, E.

2017-06-01

We present an analysis of the radial profiles of a sample of 43 H I-flux selected spiral galaxies from the Nearby Galaxies Legacy Survey (NGLS) with resolved James Clerk Maxwell Telescope (JCMT) CO J = 3 - 2 and/or Very Large Array (VLA) H I maps. Comparing the Virgo and non-Virgo populations, we confirm that the H I discs are truncated in the Virgo sample, even for these relatively H I-rich galaxies. On the other hand, the H2 distribution is enhanced for the Virgo galaxies near their centres, resulting in higher H2 to H I ratios and steeper H2 and total gas radial profiles. This is likely due to the effects of moderate ram pressure stripping in the cluster environment, which would preferentially remove low-density gas in the outskirts while enhancing higher density gas near the centre. Combined with Hα star formation rate data, we find that the star formation efficiency (SFR/H2) is relatively constant with radius for both samples, but the Virgo galaxies have an ˜40 per cent lower star formation efficiency than the non-Virgo galaxies.

The impact of baryonic discs on the shapes and profiles of self-interacting dark matter halos

NASA Astrophysics Data System (ADS)

Sameie, Omid; Creasey, Peter; Yu, Hai-Bo; Sales, Laura V.; Vogelsberger, Mark; Zavala, Jesús

2018-06-01

We employ isolated N-body simulations to study the response of self-interacting dark matter (SIDM) halos in the presence of the baryonic potentials. Dark matter self-interactions lead to kinematic thermalization in the inner halo, resulting in a tight correlation between the dark matter and baryon distributions. A deep baryonic potential shortens the phase of SIDM core expansion and triggers core contraction. This effect can be further enhanced by a large self-scattering cross section. We find the final SIDM density profile is sensitive to the baryonic concentration and the strength of dark matter self-interactions. Assuming a spherical initial halo, we also study evolution of the SIDM halo shape together with the density profile. The halo shape at later epochs deviates from spherical symmetry due to the influence of the non-spherical disc potential, and its significance depends on the baryonic contribution to the total gravitational potential, relative to the dark matter one. In addition, we construct a multi-component model for the Milky Way, including an SIDM halo, a stellar disc and a bulge, and show it is consistent with observations from stellar kinematics and streams.

Impact of a Traditional Dietary Supplement with Coconut Milk and Soya Milk on the Lipid Profile in Normal Free Living Subjects

PubMed Central

Ekanayaka, R. A. I.; Ekanayaka, N. K.; Perera, B.; De Silva, P. G. S. M.

2013-01-01

Background. The effects of coconut fat and soya fat on serum lipids are controversial. This study was designed to investigate the lipid effects of coconut milk and soya milk supplementation on the lipid profile of free living healthy subjects. Methods. Sixty (60) healthy volunteers aged 18–57 years were given coconut milk porridge (CMP) for 5 days of the week for 8 weeks, followed by a 2-week washout period, subsequent to which they received isoenergetic soya milk porridge (SMP) for 8 weeks. Results. The LDL (low density lipoprotein) levels decreased with CMP and reached statistical significance in the total study population and in the >130 baseline LDL group. The HDL (high density lipoprotein) levels rose significantly with CMP supplementation (P = 0.000). Conclusions. We conclude that coconut fat in the form of CM does not cause a detrimental effect on the lipid profile in the general population and in fact is beneficial due to the decrease in LDL and rise in HDL. SMP will be of benefit only in those whose baseline LDL levels are elevated. PMID:24282632

Properties of ion temperature gradient and trapped electron modes in tokamak plasmas with inverted density profiles

NASA Astrophysics Data System (ADS)

Du, Huarong; Jhang, Hogun; Hahm, T. S.; Dong, J. Q.; Wang, Z. X.

2017-12-01

We perform a numerical study of linear stability of the ion temperature gradient (ITG) mode and the trapped electron mode (TEM) in tokamak plasmas with inverted density profiles. A local gyrokinetic integral equation is applied for this study. From comprehensive parametric scans, we obtain stability diagrams for ITG modes and TEMs in terms of density and temperature gradient scale lengths. The results show that, for the inverted density profile, there exists a normalized threshold temperature gradient above which the ITG mode and the TEM are either separately or simultaneously unstable. The instability threshold of the TEM for the inverted density profile is substantially different from that for normal and flat density profiles. In addition, deviations are found on the ITG threshold from an early analytic theory in sheared slab geometry with the adiabatic electron response [T. S. Hahm and W. M. Tang, Phys. Fluids B 1, 1185 (1989)]. A possible implication of this work on particle transport in pellet fueled tokamak plasmas is discussed.

Tuning the density profile of surface-grafted hyaluronan and the effect of counter-ions.

PubMed

Berts, Ida; Fragneto, Giovanna; Hilborn, Jöns; Rennie, Adrian R

2013-07-01

The present paper investigates the structure and composition of grafted sodium hyaluronan at a solid-liquid interface using neutron reflection. The solvated polymer at the surface could be described with a density profile that decays exponentially towards the bulk solution. The density profile of the polymer varied depending on the deposition protocol. A single-stage deposition resulted in denser polymer layers, while layers created with a two-stage deposition process were more diffuse and had an overall lower density. Despite the diffuse density profile, two-stage deposition leads to a higher surface excess. Addition of calcium ions causes a strong collapse of the sodium hyaluronan chains, increasing the polymer density near the surface. This effect is more pronounced on the sample prepared by two-stage deposition due to the initial less dense profile. This study provides an understanding at a molecular level of how surface functionalization alters the structure and how surface layers respond to changes in calcium ions in the solvent.

Coconut oil consumption and cardiovascular risk factors in humans

PubMed Central

Eyres, Michael F.; Chisholm, Alexandra; Brown, Rachel C.

2016-01-01

Coconut oil is being heavily promoted as a healthy oil, with benefits that include support of heart health. To assess the merits of this claim, the literature on the effect of coconut consumption on cardiovascular risk factors and outcomes in humans was reviewed. Twenty-one research papers were identified for inclusion in the review: 8 clinical trials and 13 observational studies. The majority examined the effect of coconut oil or coconut products on serum lipid profiles. Coconut oil generally raised total and low-density lipoprotein cholesterol to a greater extent than cis unsaturated plant oils, but to a lesser extent than butter. The effect of coconut consumption on the ratio of total cholesterol to high-density lipoprotein cholesterol was often not examined. Observational evidence suggests that consumption of coconut flesh or squeezed coconut in the context of traditional dietary patterns does not lead to adverse cardiovascular outcomes. However, due to large differences in dietary and lifestyle patterns, these findings cannot be applied to a typical Western diet. Overall, the weight of the evidence from intervention studies to date suggests that replacing coconut oil with cis unsaturated fats would alter blood lipid profiles in a manner consistent with a reduction in risk factors for cardiovascular disease. PMID:26946252

The assessment of serum lipid profiles of children with attention deficit hyperactivity disorder.

PubMed

Ugur, Cagatay; Uneri, Ozden Sukran; Goker, Zeynep; Sekmen, Ebru; Aydemir, Hilal; Solmaz, Esra

2018-06-01

Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent psychiatric disorders in children and the pathophysiology remains obscure. Some studies show that lipid imbalances are associated with ADHD etiology. We studied the association of serum total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglyceride (TG) levels in ADHD. We examined 88 children aged 8-12 years who were diagnosed with ADHD and 88 healthy children. The exclusion criteria were as follows: obesity, any psychotropic use in the last 3 months, presence of a chronic disease and/or malignancy, history of medically treated lipid metabolism disease in family members, intelligence quotient (IQ) < 70, and comorbidities, with the exception of oppositional defiant disorder. The sample was evaluated using a semi-structured clinical assessment interview and Conners' rating scales. Despite controlling for age, sex, and body mass index (BMI) variables, the total cholesterol and LDL levels were significantly higher in the ADHD group than the levels of healthy controls, whereas the TG and HDL cholesterol levels were similar among groups. Conners' rating scales, reflecting symptom severity, and total cholesterol, TG, HDL, and LDL levels of the ADHD group were not correlated. The study results support the difference in serum lipid and lipoprotein profiles of children with ADHD compared with healthy controls. This difference is thought to be related with changes in oxidant/antioxidant balance states in ADHD. Copyright © 2018 Elsevier B.V. All rights reserved.

Interhemispheric survey of minor upper atmospheric constituents during October - November 1976

NASA Technical Reports Server (NTRS)

Gauntner, D. J. (Compiler); Haughney, L. C. (Compiler)

1977-01-01

The CV-990 aircraft coordinated several flights with a NASA U-2 aircraft, NOAA ground station measurements in Alaska, Hawaii, and American Samoa, and with Australian and New Zealand ground stations, aircraft, and a balloon experiment in the Southern hemisphere. Data were obtained for species including ozone, total ozone, the oxides of nitrogen, the chlorofluoromethanes, water vapor, nitric acid, carbon monoxide, carbon dioxide, hydrogen chloride, Aitken nuclei, ammonia, aerosols, temperatures, and winds. Individual experiment results and selected analyses are presented. The experimental data include total column densities, latitude variations, interhemisphere differences, and vertical profiles.

Low-density lipoprotein transport in blood vessel walls of squirrel monkeys

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tompkins, R.G.; Yarmush, M.L.; Schnitzer, J.J.

1989-08-01

Transmural accumulations of low-density lipoprotein (LDL) were examined in the blood vessel walls of four squirrel monkeys. Vascular wall concentrations of LDL were measured using quantitative autoradiography after {sup 125}I-labeled LDL circulation for 30 min. Profiles of relative tissue concentration from different sections in the same region were similar to each other, and there was little animal-to-animal variation. Concentrations were highest near the luminal endothelium, lower near the medial-adventitial border, and lowest within the media. Profiles from different regions fell into three groups: (1) aortic samples had steep intimal concentration gradients and near-zero media concentrations; (2) the iliac, femoral, popliteal,more » and common carotid arteries had higher intimal concentrations than group 1 but had similar concentrations deep within the media; and (3) the cerebral and coronary arteries, inferior vena cava, and pulmonary artery had intimal concentrations that were similar to group 2, but the concentrations deep within the media were greater than either groups 1 or 2. Arterial bifurcation profiles from the inner wall and the outer walls were similar to each other and to profiles from the upstream and downstream areas. Out of 280 total sites examined, 15 examples of profiles with substantially increased concentrations near the luminal endothelium were found scattered throughout the cardiovascular system, demonstrating that there are focal regions throughout the cardiovascular system which have greatly increased {sup 125}I-LDL transendothelial permeability.« less

Stationary self-focusing of intense laser beam in cold quantum plasma using ramp density profile

DOE Office of Scientific and Technical Information (OSTI.GOV)

Habibi, M.; Ghamari, F.

2012-10-15

By using a transient density profile, we have demonstrated stationary self-focusing of an electromagnetic Gaussian beam in cold quantum plasma. The paper is devoted to the prospects of using upward increasing ramp density profile of an inhomogeneous nonlinear medium with quantum effects in self-focusing mechanism of high intense laser beam. We have found that the upward ramp density profile in addition to quantum effects causes much higher oscillation and better focusing of laser beam in cold quantum plasma in comparison to that in the classical relativistic case. Our computational results reveal the importance and influence of formation of electron densitymore » profiles in enhancing laser self-focusing.« less

Changes in serum lipid profile of obese or overweight children and adolescents following a lifestyle modification course.

PubMed

Kelishadi, Roya; Hashemipour, Mahin; Sheikh-Heidar, Ahmad; Ghatreh-Samani, Shohreh

2012-01-01

Considering rapid global increase in children obesity and high prevalence of dyslipidemia in obese and overweight children, this study aimed to evaluate the effect of an educational course on changes of lipid profile in children. This non-pharmacological clinical trial study was performed on 4-18 year-old children attending outpatient clinics of Isfahan Endocrine and Metabolism Research Center (Iran). Anthropometric measurements were conducted for all children. Fasting blood samples were taken from right hand of the participants at the first laboratory visit. Biochemical tests including measurement of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were also carried out. Children took part in one educational session in which they were taught about ways and benefits of having regular physical activity once a day and having healthy foods. All children were followed up for about four months and anthropometrics and biochemical tests were repeated. Data was analyzed using SPSS16. A total number of 412 children (245 girls and 167 boys) were divided into four age groups of under 6, 6-9, 10-13, and 14-18 years old. Baseline anthropometric measures were significantly higher in boys. However, there was no difference between boys and girls in baseline lipid profile. Children's body mass index (BMI) z-score increased in all age groups except for 14-18 year-old boys. In boys older than 10 years, there were significant reductions in LDL-C and TC. In girls over 10 years of age, there was a significant increase in HDL-C. Although anthropometric measurements did not change in children (except for 14-18 year-old-boys), there was a significant reduction in children's lipid profile after the study. Our study showed that although one session of interventional education had no significant effects on children's anthropometric measurements, it could change their lipid profile. Moreover, the intervention was more effective on improving lipid profile in children over 10 years of age. Therefore, effective interventional strategies must be invented and implemented on children based on their age group.

Vegan diet and blood lipid profiles: a cross-sectional study of pre and postmenopausal women.

PubMed

Huang, Yee-Wen; Jian, Zhi-Hong; Chang, Hui-Chin; Nfor, Oswald Ndi; Ko, Pei-Chieh; Lung, Chia-Chi; Lin, Long-Yau; Ho, Chien-Chang; Chiang, Yi-Chen; Liaw, Yung-Po

2014-04-08

Vegan diet has been associated with lower risk of cardiovascular diseases and mortality, partly due to its effects on serum lipid profiles. Lipid profiles [high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C) and triglycerides (TG)] have not been fully elucidated either in pre and postmenopausal vegans or in ovo-lacto vegetarians. This study aimed to compare lipid profiles among vegans, ovo-lacto vegetarians and omnivores. Demographic data and lipid profiles were obtained from the 2002 Taiwanese Survey on Hypertension, Hyperglycemia and Hyperlipidemia. Multivariate linear regression analysis was used to examine factors significantly and independently associated with different categories of veganism and to estimate the β value of lipid profiles in the dietary types. A total of 2397 premenopausal and 1154 postmenopausal participants who did not receive lipid lowering drugs were enrolled. Premenopausal vegans had significantly lower HDL-C and higher TG, LDL-C/HDL-C, total cholesterol (TC)/HDL-C and TG/HDL-C compared with omnivores. For postmenopausal women, vegans had lower TC while ovo-lacto vegetarians were observed with low HDL-C when compared with omnivores. Multivariate linear regression analyses showed that vegan and ovo-lacto vegetarian diets decreased HDL-C levels in premenopausal women (β = -7.63, p = 0.001 and β = -4.87, p = 0.001, respectively). There were significant associations between lower LDL-C and ovo-lacto vegetarian diets (β = -7.14, p = 0.008) and also between TG and vegan diet (β = 23.37, p = 0.008), compared with omnivorous diet. Post-menopausal women reported to have consumed either a vegan or an ovo-lacto vegetarian diet were at the risk of having low HDL-C unlike those that consumed omnivorous diets (β = -4.88, p = 0.015 and β = -4.48, p = 0.047). There were no significant changes in LDL-C in both pre and postmenopausal vegans. Vegan diet was associated with reduced HDL-C level. Because of its effects on lowering HDL-C and LDL-C, ovo-lacto vegetarian diet may be more appropriate for premenopausal women.

Therapeutic effect of probiotic dahi on plasma, aortic, and hepatic lipid profile of hypercholesterolemic rats.

PubMed

Mohania, Dheeraj; Kansal, Vinod Kumar; Shah, Dilip; Nagpal, Ravinder; Kumar, Manoj; Gautam, Sanjeev Kumar; Singh, Birbal; Behare, Pradip Vishnu

2013-09-01

This study examined the effects of probiotic dahi prepared by Lactobacillus plantarum Lp9 and dahi culture in buffalo milk on lowering cholesterol in rats fed a hypercholesterolemic basal diet. Male Wistar rats were divided into 3 groups and fed with probiotic dahi, dahi, or buffalo milk for 120 days. Following the consumption of supplements (probiotic dahi, dahi or buffalo milk), the animals were fed a basal hypercholesterolemic diet. Plasma total cholesterol and triglycerides (TAGs) were decreased by 35% and 72% in rats fed with probiotic dahi group, while cholesterol levels increased by 70% and TAGs increased by 97% in buffalo milk and 59% in dahi fed groups. Supplementation of probiotic dahi further lowered plasma low-density lipoprotein (LDL) + very-low-density lipoprotein (VLDL)- cholesterol by 59%, while it elevated plasma high-density lipoprotein (HDL)-cholesterol by 116%. As a result, atherogenic index, the ratio of HDL to LDL + VLDL was markedly improved. Deposition of cholesterol and TAGs in liver and aorta were significantly reduced in rats fed with probiotic dahi. These observations suggest that probiotic dahi may have therapeutic potential to decrease plasma, hepatic and aortic lipid profile, and attenuate diet-induced hypercholesterolemia.

Modulating efficacy of Rebaudioside A, a diterpenoid on antioxidant and circulatory lipids in experimental diabetic rats.

PubMed

Saravanan, Ramalingam; Ramachandran, Vinayagam

2013-09-01

The present study was to evaluate the protective effects of Rebaudioside A (Reb A) on antioxidant status and lipid profile in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced in Wistar rats by a single intraperitoneal administration of STZ (40mg/kg b.w). Diabetic rats showed significantly increased levels of plasma glucose, thiobarbituric acid reactive substances, hydroperoxides and decreased levels of insulin. The activity of enzymatic antioxidants (superoxide dismutase, catalase and glutathione peroxidase) and the levels of non enzymatic antioxidants (vitamin C, vitamin E and reduced glutathione) were decreased in diabetic rats. The levels of total cholesterol (TC), triglycerides (TGs), free fatty acids (FFAs), phospholipids (PLs), low density lipoproteins (LDL-cholesterol) and very low-density lipoproteins (VLDL-cholesterol) in the plasma significantly increased, while plasma high-density lipoproteins (HDL-cholesterol) were significantly decreased in diabetic rats. Oral administration of Reb A (200mg/kg b.w) brought back plasma glucose, insulin, lipid peroxidation products, enzymatic, non-enzymatic antioxidants and lipid profile levels to near normal. The results of the present investigation suggests that Reb A, a natural sweetener exhibits antilipid peroxidative, antihyperlipidemic and antioxidant properties. Copyright © 2013 Elsevier B.V. All rights reserved.

A Comprehensive Assessment of Radio Occultation Ionospheric Measurements at Mid-Latitudes

NASA Astrophysics Data System (ADS)

Keele, C.; Brum, C. G. M.; Rodrigues, F. S.; Aponte, N.; Sulzer, M. P.

2015-12-01

The GPS radio occultation (RO) has become a widely used technique for global measurements of the ionospheric electron density (Ne). To advance our understanding of the accuracy of the RO profiles at mid latitudes, we performed a comprehensive comparison of RO measurements made by the Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC) satellites and observations of Ne profiles made by the Arecibo Observatory incoherent scatter radar (ISR). COSMIC is formed by six satellites in circular, 800 km altitude low-Earth orbit (LEO) at 72° inclination. The satellites orbit in their own plane, approximately 24° apart in ascending node. The satellites are equipped with dual-frequency GPS receivers capable of making measurements of the total electron content (TEC) along the signal path and, therefore, RO observations. The Arecibo ISR, located at(18.35°N, 66.75°W; ˜28.25°N dip latitude), operates at a frequency of 430 MHz with a maximum bandwidth of about 1 MHz. The large collecting area provided by the 300 m dish antenna combined with high peak power transmitters (2.0-2.5 MW) allows the radar to make accurate Ne measurements throughout the entire ionospheric F-region and topside heights. We analyzed 74 and 89 days of line feed and Gregorian data, respectively, collected between 2006 and 2014. There were 638 RO profiles measured within 10° of latitude and 20° of longitude from Arecibo Observatory and within ±10 minutes of the radar measurements. Preliminary analyses of the observations show patterns in the relationship between densities measured by the Arecibo ISR and densities estimated from the COSMIC ROs. We will present and discuss the behavior of the patterns. We will also present results of a numerical model representing the patterns and discuss the possibility of using this model to improve RO estimates of density profiles.

Head-on collision of multistate ultralight BEC dark matter configurations

NASA Astrophysics Data System (ADS)

Guzmán, F. S.; Avilez, Ana A.

2018-06-01

Density profiles of ultralight Bose-condensate dark matter inferred from numerical simulations of structure formation, ruled by the Gross-Pitaevskii-Poisson (GPP) system of equations, have a core-tail structure. Multistate equilibrium configurations of the GPP system, on the other hand, have a similar core-tail density profile. We now submit these multistate configurations to highly dynamical scenarios and show their potential as providers of appropriate density profiles of structures. We present the simulation of head-on collisions between two equilibrium configurations of the GPP system of equations, including the collision of ground state with multistate configurations. We study the regimes of solitonic and merger behavior and show generic properties of the dynamics of the system, including the relaxation process and attractor density profiles. We show that the merger of multistate configurations has the potential to produce core-tail density profiles, with the core dominated by the ground state and the halo dominated by an additional state.

First results of the SOL reflectometer on Alcator C-Mod.

PubMed

Lau, C; Hanson, G; Lin, Y; Wilgen, J; Wukitch, S; Labombard, B; Wallace, G

2012-10-01

A swept-frequency X-mode reflectometer has been built on Alcator C-Mod to measure the scrape-off layer (SOL) density profiles adjacent to the lower hybrid launcher. The reflectometer system operates between 100 and 146 GHz at sweep rates from 10 μs to 1 ms and covers a density range of ∼10(16)-10(20) m(-3) at B(0) = 5-5.4 T. This paper discusses the analysis of reflectometer density profiles and presents first experimental results of SOL density profile modifications due to the application of lower hybrid range-of-frequencies power to L-mode discharges. Comparison between density profiles measured by the X-mode reflectometer and scanning Langmuir probes is also shown.

Analysis of lipoprotein profiles of healthy cats by gel-permeation high-performance liquid chromatography

PubMed Central

MIZUTANI, Hisashi; SAKO, Toshinori; OKUDA, Hiroko; ARAI, Nobuaki; KURIYAMA, Koji; MORI, Akihiro; YOSHIMURA, Itaru; KOYAMA, Hidekazu

2016-01-01

Density gradient ultracentrifugation (DGUC) and gel electrophoresis are conventionally used to obtain lipoprotein profiles of animals. We recently applied high-performance liquid chromatography with a gel permeation column (GP-HPLC) and an on-line dual enzymatic system to dogs for lipoprotein profile analysis. We compared the GP-HPLC with DGUC as a method to obtain a feline lipoprotein profile. The lipoprotein profiles showed large and small peaks, which corresponded to high-density lipoprotein (HDL) and low-density lipoprotein (LDL), respectively, whereas very low-density lipoprotein (VLDL) and chylomicron (CM) were only marginally detected. This profile was very similar to that of dogs reported previously. Healthy cats also had a small amount of cholesterol-rich particles distinct from the normal LDL or HDL profile. There was no difference in lipoprotein profiles between the sexes, but males had a significantly larger LDL particle size (P=0.015). This study shows the feasibility of GP-HPLC for obtaining accurate lipoprotein profiles with small sample volumes and provides valuable reference data for healthy cats that should facilitate diagnoses. PMID:27170431

Damping of Resonantly Forced Density Waves in Dense Planetary Rings

NASA Astrophysics Data System (ADS)

Lehmann, Marius; Schmidt, Jürgen; Salo, Heikki

2016-10-01

We address the stability of resonantly forced density waves in dense planetary rings.Already by Goldreich and Tremaine (1978) it has been argued that density waves might be unstable, depending on the relationship between the ring's viscosity and the surface mass density. In the recent paper (Schmidt et al. 2016) we have pointed out that when - within a fluid description of the ring dynamics - the criterion for viscous overstability is satisfied, forced spiral density waves become unstable as well. In this case, linear theory fails to describe the damping.We apply the multiple scale formalism to derive a weakly nonlinear damping relation from a hydrodynamical model.This relation describes the resonant excitation and nonlinear viscous damping of spiral density waves in a vertically integrated fluid disk with density dependent transport coefficients. The model consistently predicts linear instability of density waves in a ring region where the conditions for viscous overstability are met. In this case, sufficiently far away from the Lindblad resonance, the surface mass density perturbation is predicted to saturate to a constant value due to nonlinear viscous damping. In general the model wave damping lengths depend on a set of input parameters, such as the distance to the threshold for viscous overstability and the ground state surface mass density.Our new model compares reasonably well with the streamline model for nonlinear density waves of Borderies et al. 1986.Deviations become substantial in the highly nonlinear regime, corresponding to strong satellite forcing.Nevertheless, we generally observe good or at least qualitative agreement between the wave amplitude profiles of both models. The streamline approach is superior at matching the total wave profile of waves observed in Saturn's rings, while our new damping relation is a comparably handy tool to gain insight in the evolution of the wave amplitude with distance from resonance, and the different regimes of wave formation and the dependence on the parameters of the model.

Lower Current Large Deviations for Zero-Range Processes on a Ring

NASA Astrophysics Data System (ADS)

Chleboun, Paul; Grosskinsky, Stefan; Pizzoferrato, Andrea

2017-04-01

We study lower large deviations for the current of totally asymmetric zero-range processes on a ring with concave current-density relation. We use an approach by Jensen and Varadhan which has previously been applied to exclusion processes, to realize current fluctuations by travelling wave density profiles corresponding to non-entropic weak solutions of the hyperbolic scaling limit of the process. We further establish a dynamic transition, where large deviations of the current below a certain value are no longer typically attained by non-entropic weak solutions, but by condensed profiles, where a non-zero fraction of all the particles accumulates on a single fixed lattice site. This leads to a general characterization of the rate function, which is illustrated by providing detailed results for four generic examples of jump rates, including constant rates, decreasing rates, unbounded sublinear rates and asymptotically linear rates. Our results on the dynamic transition are supported by numerical simulations using a cloning algorithm.

Efficacy of Tribulus Terrestris Extract on the Serum Glucose and Lipids of Women with Diabetes Mellitus.

PubMed

Samani, Nasrin Babadai; Jokar, Azam; Soveid, Mahmood; Heydari, Mojtaba; Mosavat, Seyed Hamdollah

2016-05-01

Considering folkloric use of Tribulus terrestris (T. terrestris) in diabetes and proven anti-hyperglycemic and anti-hyperlipidemic effects of T. terrestris in animal studies, we aimed to evaluate the efficacy of the hydro alcoholic extract of T. terrestris on the serum glucose and lipid profile of women with diabetes mellitus. Ninety-eight diabetic women were randomly allocated to receive the T. terrestris (1000 mg/day) or placebo for three months. The patients were evaluated in terms of the fasting blood glucose, 2-hour postprandial glucose, glycosylated hemoglobin and lipid profile. T. terrestris showed a significant blood glucose lowering effect in diabetic women compared to placebo (P<0.05). Also, the total cholesterol and low-density lipoprotein of the T. terrestris group was significantly reduced compared with placebo, while no significant effect was observed in the triglyceride and high-density lipoprotein levels. This study showed preliminary promising hypoglycemic effect of T. terrestris in diabetic women.

Efficacy of Tribulus Terrestris Extract on the Serum Glucose and Lipids of Women with Diabetes Mellitus

PubMed Central

Samani, Nasrin Babadai; Jokar, Azam; Soveid, Mahmood; Heydari, Mojtaba; Mosavat, Seyed Hamdollah

2016-01-01

Background: Considering folkloric use of Tribulus terrestris (T. terrestris) in diabetes and proven anti-hyperglycemic and anti-hyperlipidemic effects of T. terrestris in animal studies, we aimed to evaluate the efficacy of the hydro alcoholic extract of T. terrestris on the serum glucose and lipid profile of women with diabetes mellitus. Methods: Ninety-eight diabetic women were randomly allocated to receive the T. terrestris (1000 mg/day) or placebo for three months. The patients were evaluated in terms of the fasting blood glucose, 2-hour postprandial glucose, glycosylated hemoglobin and lipid profile. Results: T. terrestris showed a significant blood glucose lowering effect in diabetic women compared to placebo (P<0.05). Also, the total cholesterol and low-density lipoprotein of the T. terrestris group was significantly reduced compared with placebo, while no significant effect was observed in the triglyceride and high-density lipoprotein levels. Conclusion: This study showed preliminary promising hypoglycemic effect of T. terrestris in diabetic women. PMID:27840471

Efficacy of Tribulus Terrestris Extract on the Serum Glucose and Lipids of Women with Diabetes Mellitus

PubMed Central

Samani, Nasrin Babadai; Jokar, Azam; Soveid, Mahmood; Heydari, Mojtaba; Mosavat, Seyed Hamdollah

2016-01-01

Background: Considering folkloric use of Tribulus terrestris (T. terrestris) in diabetes and proven anti-hyperglycemic and anti-hyperlipidemic effects of T. terrestris in animal studies, we aimed to evaluate the efficacy of the hydro alcoholic extract of T. terrestris on the serum glucose and lipid profile of women with diabetes mellitus. Methods: Ninety-eight diabetic women were randomly allocated to receive the T. terrestris (1000 mg/day) or placebo for three months. The patients were evaluated in terms of the fasting blood glucose, 2-hour postprandial glucose, glycosylated hemoglobin and lipid profile. Results: T. terrestris showed a significant blood glucose lowering effect in diabetic women compared to placebo (P<0.05). Also, the total cholesterol and low-density lipoprotein of the T. terrestris group was significantly reduced compared with placebo, while no significant effect was observed in the triglyceride and high-density lipoprotein levels. Conclusion: This study showed preliminary promising hypoglycemic effect of T. terrestris in diabetic women. PMID:27516681

Imaging sensor constellation for tomographic chemical cloud mapping.

PubMed

Cosofret, Bogdan R; Konno, Daisei; Faghfouri, Aram; Kindle, Harry S; Gittins, Christopher M; Finson, Michael L; Janov, Tracy E; Levreault, Mark J; Miyashiro, Rex K; Marinelli, William J

2009-04-01

A sensor constellation capable of determining the location and detailed concentration distribution of chemical warfare agent simulant clouds has been developed and demonstrated on government test ranges. The constellation is based on the use of standoff passive multispectral infrared imaging sensors to make column density measurements through the chemical cloud from two or more locations around its periphery. A computed tomography inversion method is employed to produce a 3D concentration profile of the cloud from the 2D line density measurements. We discuss the theoretical basis of the approach and present results of recent field experiments where controlled releases of chemical warfare agent simulants were simultaneously viewed by three chemical imaging sensors. Systematic investigations of the algorithm using synthetic data indicate that for complex functions, 3D reconstruction errors are less than 20% even in the case of a limited three-sensor measurement network. Field data results demonstrate the capability of the constellation to determine 3D concentration profiles that account for ~?86%? of the total known mass of material released.

Comparative analysis of growth-phase-dependent gene expression in virulent and avirulent Streptococcus pneumoniae using a high-density DNA microarray.

PubMed

Ko, Kwan Soo; Park, Sulhee; Oh, Won Sup; Suh, Ji-Yoeun; Oh, Taejeong; Ahn, Sungwhan; Chun, Jongsik; Song, Jae-Hoon

2006-02-28

The global pattern of growth-dependent gene expres-sion in Streptococcus pneumoniae strains was evalu-ated using a high-density DNA microarray. Total RNAs obtained from an avirulent S. pneumoniae strain R6 and a virulent strain AMC96-6 were used to compare the expression patterns at seven time points (2.5, 3.5, 4.5, 5.5, 6.0, 6.5, and 8.0 h). The expression profile of strain R6 changed between log and station-ary growth (the Log-Stat switch). There were clear differences between the growth-dependent gene ex-pression profiles of the virulent and avirulent pneumo-coccal strains in 367 of 1,112 genes. Transcripts of genes associated with bacterial competence and capsular polysaccharide formation, as well as clpP and cbpA, were higher in the virulent strain. Our data suggest that late log or early stationary phase may be the most virulent phase of S. pneumoniae.

Numerical calculations of non-inductive current driven by microwaves in JET

NASA Astrophysics Data System (ADS)

Kirov, K. K.; Baranov, Yu; Mailloux, J.; Nave, M. F. F.; Contributors, JET

2016-12-01

Recent studies at JET focus on analysis of the lower hybrid (LH) wave power absorption and current drive (CD) calculations by means of a new ray tracing (RT)/Fokker-Planck (FP) package. The RT code works in real 2D geometry accounting for the plasma boundary and the launcher shape. LH waves with different parallel refractive index, {{N}\\parallel} , spectra in poloidal direction can be launched thus simulating authentic antenna spectrum with rows fed by different combinations of klystrons. Various FP solvers were tested most advanced of which is a relativistic bounce averaged FP code. LH wave power deposition profiles from the new RT/FP code were compared to the experimental results from electron cyclotron emission (ECE) analysis of pulses at 3.4 T low and high density. This kind of direct comparison between power deposition profiles from experimental ECE data and numerical model were carried out for the first time for waves in the LH range of frequencies. The results were in a reasonable agreement with experimental data at lower density, line averaged values of {{n}\\text{e}}≈ 2.4× {{10}19} {{\\text{m}}-3} . At higher density, {{n}\\text{e}}≈ 3× {{10}19} {{\\text{m}}-3} , the code predicted larger on-axis LH power deposition, which is inconsistent with the experimental observations. Both calculations were unable to produce LH wave absorption at the plasma periphery, which contradicts to the analysis of the ECE data and possible sources of these discrepancies have been briefly discussed in the paper. The code was also used to calculate the LH power deposition and CD profiles for the low-density preheat phase of JET’s advanced tokamak (AT) scenario. It was found that as the density evolves from hollow to flat and then to a more peaked profile the LH power and driven current move inward i.e. towards the plasma axis. A total driven current of about 70 kA for 1 MW of launched LH power was predicted in these conditions.

No association of apolipoprotein B gene polymorphism and blood lipids in obese Egyptian subjects.

PubMed

Bogari, Neda M; Abdel-Latif, Azza M; Hassan, Maha A; Ramadan, Abeer; Fawzy, Ahmed

2015-03-18

Several environmental and genetic factors are associated with high levels of lipids in obese patients. Apolipoprotein B (ApoB) is the major protein component of low-density lipoproteins (LDL), very-low density lipoproteins (VLDL) and chylomicrons and plays a central role in lipid metabolism. Several apoB restriction fragment length polymorphisms (XbaI, EcoRI, MspI) have been reported to be associated with variation in lipid levels and obesity. To date, no data are available on the relationship between XbaI polymorphism and lipid levels in Egyptian populations. Following clinical profiling, 178 obese (body mass index [BMI] >25 kg/m(2)) and 178 age-matched non-obese (BMI ≤ 25 kg/m(2)) subjects were included in this case-control study. All samples were analysed for total cholesterol, triglycerides and HDL-cholesterol. Genetic analysis of apoB XbaI (X) was performed using Polymerase Chain Reaction-Restriction Fragment Length polymorphism (PCR-RFLP). The aim of this study was to assess the association of apoB XbaI gene polymorphism (X) and lipid profiles in obese and non-obese Egyptian populations. Obese subjects demonstrated significantly higher values of waist-to-hip ratio, blood pressure, and total lipid. However, in our sample we did not find significant differences in apoB XbaI gene polymorphism (X) genotype or allele frequencies. Moreover, none of the studied lipid parameters showed any association with the gene polymorphism. This study reveals no significant association of apoB XbaI gene polymorphism (X) with obesity or lipid profiles in an Egyptian population.

Effects of cocoa products/dark chocolate on serum lipids: a meta-analysis.

PubMed

Tokede, O A; Gaziano, J M; Djoussé, L

2011-08-01

Cocoa products, which are rich sources of flavonoids, have been shown to reduce blood pressure and the risk of cardiovascular disease. Dark chocolate contains saturated fat and is a source of dietary calories; consequently, it is important to determine whether consumption of dark chocolate adversely affects the blood lipid profile. The objective was to examine the effects of dark chocolate/cocoa product consumption on the lipid profile using published trials. A detailed literature search was conducted via MEDLINE (from 1966 to May 2010), CENTRAL and ClinicalTrials.gov for randomized controlled clinical trials assessing the effects of flavanol-rich cocoa products or dark chocolate on lipid profile. The primary effect measure was the difference in means of the final measurements between the intervention and control groups. In all, 10 clinical trials consisting of 320 participants were included in the analysis. Treatment duration ranged from 2 to 12 weeks. Intervention with dark chocolate/cocoa products significantly reduced serum low-density lipoprotein (LDL) and total cholesterol (TC) levels (differences in means (95% CI) were -5.90 mg/dl (-10.47, -1.32 mg/dl) and -6.23 mg/dl (-11.60, -0.85 mg/dl), respectively). No statistically significant effects were observed for high-density lipoprotein (HDL) (difference in means (95% CI): -0.76 mg/dl (-3.02 to 1.51 mg/dl)) and triglyceride (TG) (-5.06 mg/dl (-13.45 to 3.32 mg/dl)). These data are consistent with beneficial effects of dark chocolate/cocoa products on total and LDL cholesterol and no major effects on HDL and TG in short-term intervention trials.

More pistachio nuts for improving the blood lipid profile. Systematic review of epidemiological evidence.

PubMed

Lippi, Giuseppe; Cervellin, Gianfranco; Mattiuzzi, Camilla

2016-05-06

Recent evidence suggests that regular intake of nuts may be associated with reduction of all-cause mortality, especially cardiovascular deaths. Among all types of nuts, pistachio displays the most favorable dietary composition. Therefore, we searched Medline and ISI Web of Science to identify interventional studies which evaluated changes of conventional blood lipids after replacing part of normal caloric intake with pistachio nuts in humans. Overall, 9 studies were finally included in our systematical literature review (4 randomized crossover, 3 randomized controlled and 3 prospective). In 6/9 (67%) interventional studies total cholesterol and low-density lipoprotein cholesterol (LDL-C) decreased, whereas high-density lipoprotein cholesterol (HDL-C) increased. In all studies total cholesterol/HDL-C ratio (7/7; 100%) and LDL-C/HDL-C ratio (6/6; 100%) decreased after replacing caloric intake with pistachio nuts for not less than 3 weeks. A significant reduction of triglycerides could only be observed in 2 out of 8 studies (25%). Even more importantly, in no interventional study the intake of pistachio nuts was associated with unfavorable changes of the lipid profile. The results of our literature search provide solid evidence that intake of pistachio nuts may exerts favorable effects on the traditional blood profile, provided that their consumption does not increase the habitual or recommended daily caloric intake. It seems also reasonable to suggest that further studies aimed to investigate the favorable effects of nuts on human diseases should distinguish between one type and the others, since the different nuts exhibit unique dietary composition and may hence produce distinctive biological effects in humans.

Low serum thyroid-stimulating hormone levels are associated with lipid profile in depressive patients with long symptom duration.

PubMed

Peng, Rui; Li, Yan

2017-08-01

The current study was designed to investigate the association between serum thyroid hormones and thyroid-stimulating hormone (TSH) levels with lipid profile in depressive disorder. A total of 370 depressive individuals aged 18 years and above were recruited in this cross-section study. All participants underwent a Structured Clinical Interview for DSM-IV (SCID) and recorded the duration of their symptoms. The serum levels of total cholesterol (TCH), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), lipoprotein A (Lp(a)), high-sensitivity C-reactive protein (hsCRP), free thyroxine (FT4), free triiodothyronine (FT3) and TSH levels were determined and the ratios of TCH/HDL-C were assessed. Depressed subjects with a symptom duration ≥3 years had higher TG levels, increased TCH/HDL-C ratios and lower levels of HDL-C, FT4 and TSH compared with depressive patients with a symptom duration <3 years. Correlation analysis displayed that TSH is positively and significantly associated with TCH and LDL-C (p<0.05); the above FT4 and FT3 are negatively, significantly and respectively associated with TCH/HDL-C (p<0.05) and TCH, HDL-C, LDL-C (p<0.05). Multiple linear regression analysis indicated that serum TG and TSH levels are associated with depressive symptom duration. According to our results,These findings indicate that low serum TSH levels are associated with lipid profile, TG and TSH levels have significant association with symptom duration in depressive patients. Copyright © 2017. Published by Elsevier B.V.

Association Between Thyroid Dysfunction and Lipid Profiles Differs According to Age and Sex: Results from the Korean National Health and Nutrition Examination Survey.

PubMed

Oh, Hye-Seon; Kwon, Hyemi; Ahn, Jonghwa; Song, Eyun; Park, Suyeon; Kim, Mijin; Han, Minkyu; Jeon, Min Ji; Kim, Won Gu; Kim, Won Bae; Shong, Young Kee; Rhee, Eun-Jung; Kim, Tae Yong

2018-06-15

Lipid profiles of men and women change differently during the aging process. Guidelines recommend that dyslipidemia patients should consider screening for hypothyroidism without consideration of age or sex. Data from the sixth Korean National Health and Nutrition Examination Survey were used. A total of 4275 participants without thyroid disease and without a past history of dyslipidemia or dyslipidemia medication were evaluated. The association between thyroid dysfunction and lipid profiles (total cholesterol [TC], low-density lipoprotein cholesterol [LDLC], and triglycerides [TG]) was analyzed by age and sex. The prevalence of thyroid dysfunction was significantly different according to TC and LDLC levels (p = 0.003 and p = 0.021, respectively). In women, the weighted prevalence of thyroid dysfunction was significantly different according to levels of TC, LDLC, and TG (p = 0.007, p = 0.016, and p = 0.044, respectively). However, in men, no association was found in any of the lipid profiles. Female participants were divided into two groups using a cutoff age of 55 years. In younger women, the weighted prevalence of thyroid dysfunction was different according to the levels of TC, LDLC, and TG (p = 0.013, p = 0.007, and p = 0.007, respectively). However, in older women, no association was found for any of the lipid profiles. The prevalence of thyroid dysfunction was significantly different according to lipid profiles, and this association differed by age and sex.

Feedback control of the lower hybrid power deposition profile on Tore Supra

NASA Astrophysics Data System (ADS)

Barana, O.; Mazon, D.; Laborde, L.; Turco, F.

2007-07-01

The Tore Supra facility is well suited to study ITER relevant topics such as the real-time control of plasma current and the sustaining of steady-state discharges. This work describes a tool that was recently developed and implemented on Tore Supra to control in real time, by means of the direct knowledge of the suprathermal electron local emission profile, the width of the lower hybrid power deposition profile. This quantity can be considered to some extent equivalent to the width of the plasma current density profile in case of fully non-inductive discharges. This system takes advantage of an accurate hard x-ray diagnostics, of an efficient lower hybrid additional heating and of a reliable real-time communication network. The successful experiments carried out to test the system employed, as actuators, the parallel refractive index n// and the total power PLH. The control of the suprathermal electron local emission profile through n// was also integrated with the feedback control of the total plasma current IP with PLH and of the loop voltage Vloop with the central solenoid flux. These results demonstrate that the system is robust, reliable and able to counterbalance destabilizing events. This tool can be effectively used in the future in fully non-inductive discharges to improve the MHD stability and to maintain internal transport barriers or lower hybrid enhanced performance modes. The real-time control of the lower hybrid power deposition profile could also be used in conjunction with the electron-cyclotron radiofrequency heating for synergy studies.

Evaluation of a Magnetically-Filtered Faraday Probe for Measuring the ion Current Density Profile of a Hall Thruster

DTIC Science & Technology

2004-07-01

The ability of a magnetically-filtered Faraday probe (MFFP) to obtain the ion current density profile of a Hall thruster is investigated. The MFFP is...MFFP, boxed Faraday probe (BFP), and nude Faraday probe are used to measure the ion current density profile of a 5 kW Hall thruster operated over the

[Soil meso- and micro-fauna community structures in different urban forest types in Shanghai, China.

PubMed

Jin, Shi Ke; Wang, Juan Juan; Zhu, Sha; Zhang, Qi; Li, Xiang; Zheng, Wen Jing; You, Wen Hui

2016-07-01

Soil meso- and micro-fauna of four urban forest types in Shanghai were investigated in four months which include April 2014, July 2014, October 2014 and January 2015. A total of 2190 soil fauna individuals which belong to 6 phyla, 15 classes and 22 groups were collected. The dominant groups were Nematoda and Arcari, accounting for 56.0% and 21.8% of the total in terms of individual numbers respectively. The common groups were Enchytraeidae, Rotatoria, Collembola and Hymenoptera and they accounted for 18.7% of the total in terms of individual numbers. There was a significant difference (P<0.05) among soil meso- and micro-fauna density in the four urban forest types and the largest density was found in Metasequoia glyptostroboides forest, the smallest in Cinnamomum camphora forest. The largest groupe number was found in near-nature forest, the smallest was found in M. glyptostroboides forest. There was obvious seasonal dynamics in each urban forest type and green space which had larger density in autumn and larger groupe number in summer and autumn. In soil profiles, the degree of surface accumulation of soil meso- and micro-fauna in C. camphora forest was higher than in other forests and the vertical distribution of soil meso- and micro-fauna in near-nature forest was relatively homogeneous in four layers. Density-group index was ranked as: near-nature forest (6.953)> C. camphora forest (6.351)> Platanus forest (6.313)>M. glyptostroboides forest (5.910). The community diversity of soil fauna in each vegetation type could be displayed preferably by this index. It could be inferred through redundancy analysis (RDA) that the soil bulk density, organic matter and total nitrogen were the main environmental factors influencing soil meso- and micro-fauna community structure in urban forest. The positive correlations occurred between the individual number of Arcari, Enchytraeidae and soil organic matter and total nitrogen, as well as between the individual number of Diptera larvae, Rotatoria and soil water content.

Diverse stellar haloes in nearby Milky Way mass disc galaxies

NASA Astrophysics Data System (ADS)

Harmsen, Benjamin; Monachesi, Antonela; Bell, Eric F.; de Jong, Roelof S.; Bailin, Jeremy; Radburn-Smith, David J.; Holwerda, Benne W.

2017-04-01

We have examined the resolved stellar populations at large galactocentric distances along the minor axis (from 10 kpc up to between 40 and 75 kpc), with limited major axis coverage, of six nearby highly inclined Milky Way (MW) mass disc galaxies using Hubble Space Telescope data from the Galaxy haloes, Outer discs, Substructure, Thick discs, and Star clusters (GHOSTS) survey. We select red giant branch stars to derive stellar halo density profiles. The projected minor axis density profiles can be approximated by power laws with projected slopes of -2 to -3.7 and a diversity of stellar halo masses of 1-6 × 109 M⊙, or 2-14 per cent of the total galaxy stellar masses. The typical intrinsic scatter around a smooth power-law fit is 0.05-0.1 dex owing to substructure. By comparing the minor and major axis profiles, we infer projected axis ratios c/a at ˜25 kpc between 0.4and0.75. The GHOSTS stellar haloes are diverse, lying between the extremes charted out by the (rather atypical) haloes of the MW and M31. We find a strong correlation between the stellar halo metallicities and the stellar halo masses. We compare our results with cosmological models, finding good agreement between our observations and accretion-only models where the stellar haloes are formed by the disruption of dwarf satellites. In particular, the strong observed correlation between stellar halo metallicity and mass is naturally reproduced. Low-resolution hydrodynamical models have unrealistically high stellar halo masses. Current high-resolution hydrodynamical models appear to predict stellar halo masses somewhat higher than observed but with reasonable metallicities, metallicity gradients, and density profiles.

Association between apolipoprotein E genotype, serum lipids, and colorectal cancer in Brazilian individuals.

PubMed

Souza, D R S; Nakazone, M A; Pinhel, M A S; Alvares, R M; Monaco, A C; Pinheiro, A; Barros, C F D C; Cury, P M; Cunrath, G S; Netinho, J G

2009-05-01

We evaluated genetic variants of apolipoprotein E (APOE HhaI) and their association with serum lipids in colorectal cancer (CRC), together with eating habits and personal history. Eight-seven adults with CRC and 73 controls were studied. APOE*2 (rs7412) and APOE*4 (rs429358) were identified by polymerase chain reaction-restriction fragment length polymorphism. APOE gene polymorphisms were similar in both groups, but the epsilon4/epsilon4 genotype (6%) was present only in controls. The patients had reduced levels (mean +/- SD) of total cholesterol and low-density lipoprotein cholesterol fraction (180.4 +/- 49.5 and 116.1 +/- 43.1 mg/dL, respectively) compared to controls (204.2 +/- 55.6, P = 0.135 and 134.7 +/- 50.8 mg/dL; P = 0.330, respectively) indicating that they were not statistically significant after the Bonferroni correction. The APOE*4 allele was associated with lower levels of total cholesterol, low- and high-density lipoprotein cholesterol fraction and increased levels of very low-density lipoprotein cholesterol fraction and triglycerides only among patients (P = 0.014). There was a positive correlation between the altered lipid profile and increased body mass indexes in both groups (P < 0.010). Moreover, a higher rate of hypertension and overweight was observed in controls (P < 0.002). In conclusion, the presence of the epsilon4/epsilon4 genotype only in controls may be due to a protective effect against CRC. Lower lipid profile values among patients, even those on lipid-rich diets associated with the APOE*4 allele, suggest alterations in the lipid synthesis and metabolism pathways in CRC.

The PCOS Patients differ in Lipid Profile According to their Phenotypes.

PubMed

Spałkowska, Magdalena; Mrozińska, Sandra; Gałuszka-Bednarczyk, Anna; Gosztyła, Katarzyna; Przywara, Agnieszka; Guzik, Justyna; Janeczko, Marek; Milewicz, Tomasz; Wojas-Pelc, Anna

2018-01-31

Polycystic ovary syndrome (PCOS) affects 4-18% of women of reproductive age. The number of reports exploring the lipid profiles among PCOS patients and number of studied patients are limited. The aim of our study was to assess the lipid profile separately in lean and non-lean women with polycystic ovary syndrome divided according to hyperandrogenemia, defined as free androgen index (FAI)≥5. The second aim was to compare the lipid profiles among lean and non-lean PCOS patients with respect to hyperandrogenemia and regularity of menstruation cycles. We evaluated 232 patients from Department of Endocrinological Gynecology, Jagiellonian University Medical College in Krakow diagnosed with PCOS. The population consisted of 166 lean and 66 non-lean women. We observed higher levels of total cholesterol, high-density lipoprotein cholesterol (HDL-C) in lean patients with FAI<5 than in lean patients with FAI≥5. There were no differences in lipid profile between non-lean patients with FAI≥5 and non-lean patients with FAI<5. Among lean patients higher total cholesterol levels were observed in those with irregular menstruation cycles and FAI<5 than in patients with FAI≥5 and regular cycles. There were no differences in lipid profiles between four phenotypes among non-lean PCOS patients. The results of our study showed differences in lipid profile between lean PCOS patients according to their phenotype based on androgens' level. This effect was abandoned by fat tissue mass in non-lean ones. Further studies should be conducted to explore these associations. © Georg Thieme Verlag KG Stuttgart · New York.

Effects of fish oil on lipid profile and other metabolic outcomes in HIV-infected patients on antiretroviral therapy: a randomized placebo-controlled trial.

PubMed

Oliveira, Julicristie M; Rondó, Patrícia H C; Yudkin, John S; Souza, José M P; Pereira, Tatiane N; Catalani, Andrea W; Picone, Camila M; Segurado, Aluisio A C

2014-02-01

Although antiretroviral therapy has revolutionized the care of HIV-infected patients, it has been associated with metabolic abnormalities. Hence, this study was planned to investigate the effects of fish oil on lipid profile, insulin resistance, and body fat distribution in HIV-infected Brazilian patients on antiretroviral therapy, considering that marine omega-3 fatty acids seem to improve features of the metabolic syndrome. We conducted a randomized, parallel, placebo-controlled trial that assessed the effects of 3 g fish oil/day (540 mg of eicosapentaenoic acid plus 360 mg of docosahexaenoic acid) or 3 g soy oil/day (placebo) on 83 HIV-infected Brazilian men and non-pregnant women on antiretroviral therapy. No statistically significant relationships between fish oil supplementation and longitudinal changes in triglyceride (p = 0.335), low-density lipoprotein cholesterol (p = 0.078), high-density lipoprotein cholesterol (p = 0.383), total cholesterol (p = 0.072), apolipoprotein B (p = 0.522), apolipoprotein A1 (p = 0.420), low-density lipoprotein cholesterol/apolipoprotein B ratio (p = 0.107), homeostasis model assessment for insulin resistance index (p = 0.387), body mass index (p = 0.068), waist circumference (p = 0.128), and waist/hip ratio (p = 0.359) were observed. A low dose of fish oil did not alter lipid profile, insulin resistance, and body fat distribution in HIV-infected patients on antiretroviral therapy.

Light impurity transport in JET ILW L-mode plasmas

NASA Astrophysics Data System (ADS)

Bonanomi, N.; Mantica, P.; Giroud, C.; Angioni, C.; Manas, P.; Menmuir, S.; Contributors, JET

2018-03-01

A series of experimental observations of light impurity profiles was carried out in JET (Joint European Torus) ITER-like wall (ILW) L-mode plasmas in order to investigate their transport mechanisms. These discharges feature the presence of 3He, Be, C, N, Ne, whose profiles measured by active Charge Exchange diagnostics are compared with quasi-linear and non-linear gyro-kinetic simulations. The peaking of 3He density follows the electron density peaking, Be and Ne are also peaked, while the density profiles of C and N are flat in the mid plasma region. Gyro-kinetic simulations predict peaked density profiles for all the light impurities studied and at all the radial positions considered, and fail predicting the flat or hollow profiles observed for C and N at mid radius in our cases.

The Effects of Extended Release Niacin on Lipoprotein Sub-Particle Concentrations in HIV-Infected Patients

PubMed Central

Lin, Chunrong; Grandinetti, Andrew; Shikuma, Cecilia; Souza, Scott; Parikh, Nisha; Nakamoto, Beau; Kallianpur, Kalpana J

2013-01-01

With the advent of highly active antiretroviral therapy (HAART), Cardiovascular Disease (CVD) has emerged as the leading cause of death in Human Immunodeficiency Virus (HIV) infected patients. An atherogenic lipoprotein phenotype has been described in HIV- infected patients with a predominance of small, low density lipoprotein (SLDL) particles with accompanying elevated triglycerides and reduced high density lipoprotein cholesterol. This randomized controlled pilot study was conducted to evaluate the efficacy of Extended Release Niacin (ERN) in improving the lipid profile in HIV patients. A total of 17 HIV positive subjects on HAART therapy with High Density Lipoprotein Cholesterol (HDL) levels below 40mg/dl and Low Density Lipoprotein Cholesterol (LDL) below 130mg/dl were enrolled. Nine were randomized to be treated with ERN titrated from a starting level of 500mg/night and titrated to a level of 1500mg/night. Eight patients were assigned to the control arm. No placebo was used. Lipoprotein profiles of the subjects were analyzed at baseline and at the end of 12 weeks using Nuclear Magnetic Resonance (NMR) spectroscopy. At the end of 12 weeks, NMR spectroscopic analysis revealed a significant increase in overall LDL size (1.2% in ERN treated subjects vs 2.0% decrease in control patients, P=.04) and a decrease in small LDL particle concentration (17.0% in ERN treated subjects vs 21.4% increase in control patients, P=.03) in subjects receiving ERN as compared to those in the control group. Only 1 subject receiving ERN developed serious flushing which was attributed to an accidental overdose of the drug. This pilot study demonstrates that ERN therapy in HIV-infected patients with low HDL is safe and effective in improving the lipoprotein profile in these patients. PMID:23795312

Turbulent fluctuations during pellet injection into a dipole confined plasma torus

DOE PAGES

Garnier, D. T.; Mauel, M. E.; Roberts, T. M.; ...

2017-01-01

Here, we report measurements of the turbulent evolution of the plasma density profile following the fast injection of lithium pellets into the Levitated Dipole Experiment (LDX) [Boxer et al., Nat. Phys. 6, 207 (2010)]. As the pellet passes through the plasma, it provides a significant internal particle source and allows investigation of density profile evolution, turbulent relaxation, and turbulent fluctuations. The total electron number within the dipole plasma torus increases by more than a factor of three, and the central density increases by more than a factor of five. During these large changes in density, the shape of the densitymore » profile is nearly “stationary” such that the gradient of the particle number within tubes of equal magnetic flux vanishes. In comparison to the usual case, when the particle source is neutral gas at the plasma edge, the internal source from the pellet causes the toroidal phase velocity of the fluctuations to reverse and changes the average particle flux at the plasma edge. An edge particle source creates an inward turbulent pinch, but an internal particle source increases the outward turbulent particle flux. Statistical properties of the turbulence are measured by multiple microwave interferometers and by an array of probes at the edge. The spatial structures of the largest amplitude modes have long radial and toroidal wavelengths. Estimates of the local and toroidally averaged turbulent particle flux show intermittency and a non-Gaussian probability distribution function. The measured fluctuations, both before and during pellet injection, have frequency and wave number dispersion consistent with theoretical expectations for interchange and entropy modes excited within a dipole plasma torus having warm electrons and cool ions.« less

Mass Profile Decomposition of the Frontier Fields Cluster MACS J0416-2403: Insights on the Dark-matter Inner Profile

NASA Astrophysics Data System (ADS)

Annunziatella, M.; Bonamigo, M.; Grillo, C.; Mercurio, A.; Rosati, P.; Caminha, G.; Biviano, A.; Girardi, M.; Gobat, R.; Lombardi, M.; Munari, E.

2017-12-01

We present a high-resolution dissection of the two-dimensional total mass distribution in the core of the Hubble Frontier Fields galaxy cluster MACS J0416.1‑2403, at z = 0.396. We exploit HST/WFC3 near-IR (F160W) imaging, VLT/Multi Unit Spectroscopic Explorer spectroscopy, and Chandra data to separate the stellar, hot gas, and dark-matter mass components in the inner 300 kpc of the cluster. We combine the recent results of our refined strong lensing analysis, which includes the contribution of the intracluster gas, with the modeling of the surface brightness and stellar mass distributions of 193 cluster members, of which 144 are spectroscopically confirmed. We find that, moving from 10 to 300 kpc from the cluster center, the stellar to total mass fraction decreases from 12% to 1% and the hot gas to total mass fraction increases from 3% to 9%, resulting in a baryon fraction of approximatively 10% at the outermost radius. We measure that the stellar component represents ∼30%, near the cluster center, and 15%, at larger clustercentric distances, of the total mass in the cluster substructures. We subtract the baryonic mass component from the total mass distribution and conclude that within 30 kpc (∼3 times the effective radius of the brightest cluster galaxy) from the cluster center the surface mass density profile of the total mass and global (cluster plus substructures) dark-matter are steeper and that of the diffuse (cluster) dark-matter is shallower than an NFW profile. Our current analysis does not point to a significant offset between the cluster stellar and dark-matter components. This detailed and robust reconstruction of the inner dark-matter distribution in a larger sample of galaxy clusters will set a new benchmark for different structure formation scenarios.

Effects of testosterone treatment on bone mineral density in men with testosterone deficiency syndrome.

PubMed

Rodriguez-Tolrà, J; Torremadé, J; di Gregorio, S; Del Rio, L; Franco, E

2013-07-01

The decline in testosterone levels found in men with testosterone deficiency syndrome (TDS) is associated with a decrease in bone mineral density (BMD). To study the safety profile and efficacy of testosterone treatment on BMD in patients with TDS. In this 2-year prospective open-label study, patients were administered 50 mg of testosterone gel daily (adjustable after 3 months up to 75-100 mg or down to 25 mg) for 12 months, followed by treatment with 1000 mg of testosterone undecanoate every 2-3 months from months 12-24. Outcome measures were as follows: (i) Changes in clinical chemistry safety parameters and total testosterone, sex hormone binding globulin and calculated free testosterone (cFT) levels; (ii) Changes in Aging Males' Symptoms Scale (AMS) and International Prostate Symptom Score scores; and (iii) Changes in lumbar spine and hip BMD. A total of 50 men aged 50-65 years with TDS (AMS >26 and cFT <0.250 nmol/mL) took part in the study. There was no significant impact of testosterone on safety. Prostate-specific antigen and haematopoietic parameters increased significantly, although the changes were not clinically significant. Total and cFT increased significantly after 3 months (p < 0.001) and there were significant improvements after 3 months in AMS scores (p < 0.001). BMD improved significantly in L2-L4 (2.90 and 4.5%), total femur (0.74 and 3%) and trochanter (1.09 and 3.2%) at 12 and 24 months respectively. Testosterone treatment in men with TDS has a good safety profile, leads to significant improvement in lumbar spine and hip BMD, and improves symptoms, as assessed by the AMS questionnaire. © 2013 American Society of Andrology and European Academy of Andrology.

Surface currents associated with external kink modes in tokamak plasmas during a major disruption

NASA Astrophysics Data System (ADS)

Ng, C. S.; Bhattacharjee, A.

2017-10-01

The surface current on the plasma-vacuum interface during a disruption event involving kink instability can play an important role in driving current into the vacuum vessel. However, there have been disagreements over the nature or even the sign of the surface current in recent theoretical calculations based on idealized step-function background plasma profiles. We revisit such calculations by replacing step-function profiles with more realistic profiles characterized by a strong but finite gradient along the radial direction. It is shown that the resulting surface current is no longer a delta-function current density, but a finite and smooth current density profile with an internal structure, concentrated within the region with a strong plasma pressure gradient. Moreover, this current density profile has peaks of both signs, unlike the delta-function case with a sign opposite to, or the same as the plasma current. We show analytically and numerically that such current density can be separated into two parts, with one of them, called the convective current density, describing the transport of the background plasma density by the displacement, and the other part that remains, called the residual current density. It is argued that consideration of both types of current density is important and can resolve past controversies.

Golden gravitational lensing systems from the Sloan Lens ACS Survey - II. SDSS J1430+4105: a precise inner total mass profile from lensing alone

NASA Astrophysics Data System (ADS)

Eichner, Thomas; Seitz, Stella; Bauer, Anne

2012-12-01

We study the Sloan Lens ACS (SLACS) survey strong-lensing system SDSS J1430+4105 at zl = 0.285. The lensed source (zs = 0.575) of this system has a complex morphology with several subcomponents. Its subcomponents span a radial range from 4 to 10 kpc in the plane of the lens. Therefore, we can constrain the slope of the total projected mass profile around the Einstein radius from lensing alone. We measure a density profile that is slightly but not significantly shallower than isothermal at the Einstein radius. We decompose the mass of the lensing galaxy into a de Vaucouleurs component to trace the stars and an additional dark component. The spread of multiple-image components over a large radial range also allows us to determine the amplitude of the de Vaucouleurs and dark matter components separately. We get a mass-to-light ratio of M de Vauc LB ≈ (5.5±1.5) M⊙L⊙,B and a dark matter fraction within the Einstein radius of ≈20 to 40 per cent. Modelling the star formation history assuming composite stellar populations at solar metallicity to the galaxy's photometry yields a mass-to-light ratio of M, salp LB ≈ 4.0-1.3+0.6 M⊙L⊙,B and M, chab LB ≈ 2.3-0.8+0.3 M⊙L⊙,B for Salpeter and Chabrier initial mass functions, respectively. Hence, the mass-to-light ratio derived from lensing is more Salpeter like, in agreement with results for massive Coma galaxies and other nearby massive early-type galaxies. We examine the consequences of the galaxy group in which the lensing galaxy is embedded, showing that it has little influence on the mass-to-light ratio obtained for the de Vaucouleurs component of the lensing galaxy. Finally, we decompose the projected, azimuthally averaged 2D density distribution of the de Vaucouleurs and dark matter components of the lensing signal into spherically averaged 3D density profiles. We can show that the 3D dark and luminous matter density within the Einstein radius (REin ≈ 0.6 Reff) of this SLACS galaxy is similar to the values of Coma galaxies with the same velocity dispersions.

Stratospheric ozone measurement with an infrared heterodyne spectrometer

NASA Technical Reports Server (NTRS)

Abbas, M. M.; Kostiuk, T.; Mumma, M. J.; Buhl, D.; Kunde, V. G.; Brown, L. W.; Spears, D.

1978-01-01

A stratospheric ozone absorption line in the 10 micron band was measured and resolved completely, using an infrared heterodyne spectrometer with a spectral resolution of 5 MHz. The vertical concentration profile of stratospheric ozone was obtained through an analytical inversion of the measured spectra line profile. The absolute total column density was 0.32 plus or minus 0.02 cm-atm with a peak mixing ratio occurring at approximately 24 km. The (7,1,6) - (7,1,7) O3 line center frequency was found to be 1043.1772 plus or minus 0.00033 cm/1 or 420 plus or minus 10 MHz higher than the P(24) CO2 laser line frequency.

Stratospheric ozone measurement with an infrared heterodyne spectrometer

NASA Technical Reports Server (NTRS)

Abbas, M. M.; Kostiuk, T.; Mumma, M. J.; Buhl, D.; Kunde, V. G.; Brown, L. W.

1978-01-01

A stratospheric ozone absorption line in the 10 microns band was measured and resolved completely, using an infrared heterodyne spectrometer with spectral resolution of 5 MHz (0.000167 cm to -1 power). The vertical concentration profile of stratospheric ozone was obtained through an analytical inversion of the measured spectral line profile. The absolute total column density was 0.34 cm atm with a peak mixing ratio occurring at approximately 24 km. The (7,1,6) to (7,1,7) O3 line center frequency was found to be 1043.1775 + or - 0.00033 cm to toe -1 power, or 430 + or - 10 MHz higher than the P(24) CO2 laser line frequency.

Effects of pressing schedule on formation of vertical density profile for MDF panels

Treesearch

Zhiyong Cai; James H. Muehl; Jerrold E. Winandy

2006-01-01

A fundamental understanding of mat consolidation during hot pressing will help to optimize the medium-density fiberboard (MDF) manufacturing process by increasing productivity, improving product quality, and enhancing durability. Effects of panel density, fiber moisture content (MC), and pressing schedule on formation of vertical density profile (VDP) during hot...

A technique for routinely updating the ITU-R database using radio occultation electron density profiles

NASA Astrophysics Data System (ADS)

Brunini, Claudio; Azpilicueta, Francisco; Nava, Bruno

2013-09-01

Well credited and widely used ionospheric models, such as the International Reference Ionosphere or NeQuick, describe the variation of the electron density with height by means of a piecewise profile tied to the F2-peak parameters: the electron density,, and the height, . Accurate values of these parameters are crucial for retrieving reliable electron density estimations from those models. When direct measurements of these parameters are not available, the models compute the parameters using the so-called ITU-R database, which was established in the early 1960s. This paper presents a technique aimed at routinely updating the ITU-R database using radio occultation electron density profiles derived from GPS measurements gathered from low Earth orbit satellites. Before being used, these radio occultation profiles are validated by fitting to them an electron density model. A re-weighted Least Squares algorithm is used for down-weighting unreliable measurements (occasionally, entire profiles) and to retrieve and values—together with their error estimates—from the profiles. These values are used to monthly update the database, which consists of two sets of ITU-R-like coefficients that could easily be implemented in the IRI or NeQuick models. The technique was tested with radio occultation electron density profiles that are delivered to the community by the COSMIC/FORMOSAT-3 mission team. Tests were performed for solstices and equinoxes seasons in high and low-solar activity conditions. The global mean error of the resulting maps—estimated by the Least Squares technique—is between and elec/m for the F2-peak electron density (which is equivalent to 7 % of the value of the estimated parameter) and from 2.0 to 5.6 km for the height (2 %).

10 GY TOTAL BODY IRRADIATION INCREASES RISK OF CORONARY SCLEROSIS, DEGENERATION OF HEART STRUCTURE AND FUNCTION IN A RAT MODEL

PubMed Central

Baker, John E; Fish, Brian L; Su, Jidong; Haworth, Steven T; Strande, Jennifer L; Komorowski, Richard A; Migrino, Raymond Q; Doppalapudi, Anil; Harmann, Leanne; Li, X Allen; Hopewell, John W; Moulder, John E

2009-01-01

Purpose To determine the impact of 10 Gy total body irradiation (TBI) or local thorax irradiation, a dose relevant to a radiological terrorist threat, on lipid and liver profile, coronary microvasculature and ventricular function. Materials and methods WAG/RijCmcr rats received 10 Gy TBI followed by bone marrow transplantation, or 10 Gy local thorax irradiation. Age-matched, non-irradiated rats served as controls. The lipid profile and liver enzymes, coronary vessel morphology, nitric oxide synthase (NOS) isoforms, protease activated receptor (PAR)-1 expression and fibrinogen levels were compared. Two dimensional strain echocardiography assessed global radial and circumferential strain on the heart. Results TBI resulted in a sustained increase in total and low density lipoprotein (LDL) cholesterol (190±8 vs. 58±6; 82±8 vs. 13±3 mg/dL, respectively). The density of small coronary arterioles was decreased by 32%. Histology revealed complete blockage of some vessels while cardiomyocytes remained normal. TBI resulted in cellular peri-arterial fibrosis whereas control hearts had symmetrical penetrating vessels with less collagen and fibroblasts. TBI resulted in a 32±4% and 28±3% decrease in endothelial NOS and inducible NOS protein respectively, and a 21±4% and 35±5% increase in fibrinogen and PAR-1 protein respectively, after 120 days. TBI reduced radial strain (19±8 vs. 46±7%) and circumferential strain (-8±3 vs. −15±3%) compared to controls. Thorax-only irradiation produced no changes over the same time frame. Conclusions TBI with 10 Gy, a dose relevant to radiological terrorist threats, worsened lipid profile, injured coronary microvasculature, altered endothelial physiology and myocardial mechanics. These changes were not manifest with local thorax irradiation. Non-thoracic circulating factors may be promoting radiation-induced injury to the heart. PMID:19995235

Implementation of the new multichannel X-mode edge density profile reflectometer for the ICRF antenna on ASDEX Upgrade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aguiam, D. E., E-mail: daguiam@ipfn.tecnico.ulisboa.pt; Silva, A.; Carvalho, P. J.

A new multichannel frequency modulated continuous-wave reflectometry diagnostic has been successfully installed and commissioned on ASDEX Upgrade to measure the plasma edge electron density profile evolution in front of the Ion Cyclotron Range of Frequencies (ICRF) antenna. The design of the new three-strap ICRF antenna integrates ten pairs (sending and receiving) of microwave reflectometry antennas. The multichannel reflectometer can use three of these to measure the edge electron density profiles up to 2 × 10{sup 19} m{sup −3}, at different poloidal locations, allowing the direct study of the local plasma layers in front of the ICRF antenna. ICRF power coupling,more » operational effects, and poloidal variations of the plasma density profile can be consistently studied for the first time. In this work the diagnostic hardware architecture is described and the obtained density profile measurements were used to track outer radial plasma position and plasma shape.« less

The atmospheric emission method of calculating the neutral atmosphere and charged particle densities in the upper atmosphere

NASA Astrophysics Data System (ADS)

McElroy, Kenneth L., Jr.

1992-12-01

A method is presented for the determination of neutral gas densities in the ionosphere from rocket-borne measurements of UV atmospheric emissions. Computer models were used to calculate an initial guess for the neutral atmosphere. Using this neutral atmosphere, intensity profiles for the N2 (0,5) Vegard-Kaplan band, the N2 Lyman-Birge-Hopfield band system, and the OI2972 A line were calculated and compared with the March 1990 NPS MUSTANG data. The neutral atmospheric model was modified and the intensity profiles recalculated until a fit with the data was obtained. The neutral atmosphere corresponding to the intensity profile that fit the data was assumed to be the atmospheric composition prevailing at the time of the observation. The ion densities were then calculated from the neutral atmosphere using a photochemical model. The electron density profile calculated by this model was compared with the electron density profile measured by the U.S. Air Force Geophysics Laboratory at a nearby site.

A LOFAR census of non-recycled pulsars: average profiles, dispersion measures, flux densities, and spectra

NASA Astrophysics Data System (ADS)

Bilous, A. V.; Kondratiev, V. I.; Kramer, M.; Keane, E. F.; Hessels, J. W. T.; Stappers, B. W.; Malofeev, V. M.; Sobey, C.; Breton, R. P.; Cooper, S.; Falcke, H.; Karastergiou, A.; Michilli, D.; Osłowski, S.; Sanidas, S.; ter Veen, S.; van Leeuwen, J.; Verbiest, J. P. W.; Weltevrede, P.; Zarka, P.; Grießmeier, J.-M.; Serylak, M.; Bell, M. E.; Broderick, J. W.; Eislöffel, J.; Markoff, S.; Rowlinson, A.

2016-06-01

We present first results from a LOFAR census of non-recycled pulsars. The census includes almost all such pulsars known (194 sources) at declinations Dec > 8° and Galactic latitudes |Gb| > 3°, regardless of their expected flux densities and scattering times. Each pulsar was observed for ≥20 min in the contiguous frequency range of 110-188 MHz. Full-Stokes data were recorded. We present the dispersion measures, flux densities, and calibrated total intensity profiles for the 158 pulsars detected in the sample. The median uncertainty in census dispersion measures (1.5 × 10-3 pc cm-3) is ten times smaller, on average, than in the ATNF pulsar catalogue. We combined census flux densities with those in the literature and fitted the resulting broadband spectra with single or broken power-law functions. For 48 census pulsars such fits are being published for the first time. Typically, thechoice between single and broken power-laws, as well as the location of the spectral break, were highly influenced by the spectral coverage of the available flux density measurements. In particular, the inclusion of measurements below 100 MHz appears essential for investigating the low-frequency turnover in the spectra for most of the census pulsars. For several pulsars, we compared the spectral indices from different works and found the typical spread of values to be within 0.5-1.5, suggesting a prevailing underestimation of spectral index errors in the literature. The census observations yielded some unexpected individual source results, as we describe in the paper. Lastly, we will provide this unique sample of wide-band, low-frequency pulse profiles via the European Pulsar Network Database. Tables B.1-B.4 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/591/A134

Effect of Control Blade History, and Axial Coolant Density and Burnup Profiles on BWR Burnup Credit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marshall, William BJ J

2016-01-01

A technical basis for peak reactivity boiling water reactor (BWR) burnup credit (BUC) methods was recently generated, and the technical basis for extended BWR BUC is now being developed. In this paper, a number of effects related to extended BWR BUC are analyzed, including three major operational effects in BWRs: the coolant density axial distribution, the use of control blades during operation, and the axial burnup profile. Specifically, uniform axial moderator density profiles are analyzed and compared to previous results and an additional temporal fidelity study combing moderator density profiles for three different fuel assemblies is presented. Realistic control blademore » histories and cask criticality results are compared to previously generated constructed control blade histories. Finally, a preliminary study of the axial burnup profile is provided.« less

Kinetic simulations of the stability of a plasma confined by the magnetic field of a current rod

NASA Astrophysics Data System (ADS)

Tonge, J.; Leboeuf, J. N.; Huang, C.; Dawson, J. M.

2003-09-01

The kinetic stability of a plasma in the magnetic field of a current rod is investigated for various temperature and density profiles using three-dimensional particle-in-cell simulations. Such a plasma obeys similar physics to a plasma in a dipole magnetic field, while it is easier to perform computer simulations, and do theoretical analysis, of a plasma in the field of a current rod. Simple energy principle calculations and simulations with a variety of temperature and density profiles show that the plasma is stable to interchange for pressure profiles proportional to r-10/3. As predicted by theory the simulations also show that the density profile will be stationary as long as density is proportional to r-2 even though the temperature profile may not be stable.

Better Than Counting: Density Profiles from Force Sampling

NASA Astrophysics Data System (ADS)

de las Heras, Daniel; Schmidt, Matthias

2018-05-01

Calculating one-body density profiles in equilibrium via particle-based simulation methods involves counting of events of particle occurrences at (histogram-resolved) space points. Here, we investigate an alternative method based on a histogram of the local force density. Via an exact sum rule, the density profile is obtained with a simple spatial integration. The method circumvents the inherent ideal gas fluctuations. We have tested the method in Monte Carlo, Brownian dynamics, and molecular dynamics simulations. The results carry a statistical uncertainty smaller than that of the standard counting method, reducing therefore the computation time.

Expected thermal deformation and wavefront preservation of a cryogenic Si monochromator for Cornell ERL beamlines

PubMed Central

Huang, Rong; Bilderback, Donald H.; Finkelstein, Kenneth

2014-01-01

Cornell energy-recovery linac (ERL) beamlines will have higher power density and higher fractional coherence than those available at third-generation sources; therefore the capability of a monochromator for ERL beamlines has to be studied. A cryogenic Si monochromator is considered in this paper because the perfect atomic structure of Si crystal is needed to deliver highly coherent radiation. Since neither the total heat load nor the power density alone can determine the severity of crystal deformation, a metric called modified linear power density is used to gauge the thermal deformation. For all ERL undulator beamlines, crystal thermal deformation profiles are simulated using the finite-element analysis tool ANSYS, and wavefront propagations are simulated using Synchrotron Radiation Workshop. It is concluded that cryogenic Si monochromators will be suitable for ERL beamlines in general. PMID:24562557

Stochastic approach and fluctuation theorem for charge transport in diodes

NASA Astrophysics Data System (ADS)

Gu, Jiayin; Gaspard, Pierre

2018-05-01

A stochastic approach for charge transport in diodes is developed in consistency with the laws of electricity, thermodynamics, and microreversibility. In this approach, the electron and hole densities are ruled by diffusion-reaction stochastic partial differential equations and the electric field generated by the charges is determined with the Poisson equation. These equations are discretized in space for the numerical simulations of the mean density profiles, the mean electric potential, and the current-voltage characteristics. Moreover, the full counting statistics of the carrier current and the measured total current including the contribution of the displacement current are investigated. On the basis of local detailed balance, the fluctuation theorem is shown to hold for both currents.

Review of 5 years of a combined dietary and physical fitness intervention for control of serum cholesterol

NASA Technical Reports Server (NTRS)

Angotti, C. M.; Levine, M. S.

1994-01-01

A chart review covering the first 5 years of clinical experience with a combined dietary and exercise intervention program for the reduction of hypercholesterolemia at the National Aeronautics and Space Administration headquarters demonstrated the program's success in maintaining high-density lipoprotein cholesterol (HDL-C) levels while significantly lowering total serum cholesterol levels. This combined program also resulted in improved ratios of total serum cholesterol to HDL-C and lowered levels of low-density lipoprotein cholesterol, thus further reducing the risk for cardiovascular disease. The National Aeronautics and Space Administration Cardiovascular Risk Reduction Program was developed after it was determined that although dietary intervention alone improved total cholesterol levels, it often resulted in a more than proportionate decrease in HDL-C and a worsening of the ratio of cholesterol to HDL-C. An approach was needed that would positively affect all factors of the lipid profile. The findings from the program indicate that reduction of cardiovascular risk can be accomplished easily and effectively at the worksite through dietary intervention, personal monitoring, and a reasonable exercise program.

Characteristics of ionospheric electron density profiles in the auroral and polar cap regions from long-term incoherent scatter radar observations

NASA Astrophysics Data System (ADS)

Jee, G.; Kim, E.; Kwak, Y. S.; Kim, Y.; Kil, H.

2017-12-01

We investigate the climatological characteristics of the ionospheric electron density profiles in the auroral and polar cap regions in comparison with the mid-latitude ionosphere using incoherent scatter radars (ISR) observations from Svalbard (78.15N, 16.05E), Tromso (69.59N, 19.23E), and Millstone Hill (42.6N, 288.5E) during a period of 1995 - 2015. Diurnal variations of electron density profiles from 100 to 500 km are compared among the three radar observations during equinox, summer and winter solstice for different solar and geomagnetic activities. Also investigated are the physical characteristics of E-region and F-region peak parameters of electron density profiles in the auroral and polar cap regions, which are significantly different from the mid-latitude ionosphere. In the polar ionosphere, the diurnal variations of density profiles are extremely small in summer hemisphere. Semiannual anomaly hardly appears for all latitudes, but winter anomaly occurs at mid-latitude and auroral ionospheres for high solar activity. Nighttime density becomes larger than daytime density in the winter polar cap ionosphere for high solar activity. The E-region peak is very distinctive in the nighttime auroral region and the peak height is nearly constant at about 110 km for all conditions. Compared with the F-region peak density, the E-region peak density does not change much with solar activity. Furthermore, the E-region peak density can be even larger than F-region density for low solar activity in the auroral region, particularly during disturbed condition.

[Effects of soil data and map scale on assessment of total phosphorus storage in upland soils.

PubMed

Li, Heng Rong; Zhang, Li Ming; Li, Xiao di; Yu, Dong Sheng; Shi, Xue Zheng; Xing, Shi He; Chen, Han Yue

2016-06-01

Accurate assessment of total phosphorus storage in farmland soils is of great significance to sustainable agricultural and non-point source pollution control. However, previous studies haven't considered the estimation errors from mapping scales and various databases with different sources of soil profile data. In this study, a total of 393×10 4 hm 2 of upland in the 29 counties (or cities) of North Jiangsu was cited as a case for study. Analysis was performed of how the four sources of soil profile data, namely, "Soils of County", "Soils of Prefecture", "Soils of Province" and "Soils of China", and the six scales, i.e. 1:50000, 1:250000, 1:500000, 1:1000000, 1:4000000 and1:10000000, used in the 24 soil databases established for the four soil journals, affected assessment of soil total phosphorus. Compared with the most detailed 1:50000 soil database established with 983 upland soil profiles, relative deviation of the estimates of soil total phosphorus density (STPD) and soil total phosphorus storage (STPS) from the other soil databases varied from 4.8% to 48.9% and from 1.6% to 48.4%, respectively. The estimated STPD and STPS based on the 1:50000 database of "Soils of County" and most of the estimates based on the databases of each scale in "Soils of County" and "Soils of Prefecture" were different, with the significance levels of P＜0.001 or P＜0.05. Extremely significant differences (P＜0.001) existed between the estimates based on the 1:50000 database of "Soils of County" and the estimates based on the databases of each scale in "Soils of Province" and "Soils of China". This study demonstrated the significance of appropriate soil data sources and appropriate mapping scales in estimating STPS.

Impact of daily Chlorella consumption on serum lipid and carotenoid profiles in mildly hypercholesterolemic adults: a double-blinded, randomized, placebo-controlled study

PubMed Central

2014-01-01

Background High level of serum cholesterol is considered to be a major risk factor for cardiovascular disease (CVD). A double-blinded, randomized, placebo-controlled trial was performed to test the hypothesis that a daily intake of Chlorella may improve serum lipid profile through enhancement of serum carotenoid concentration in mildly hypercholesterolemic subjects. Methods Eligible subjects (n = 63) were randomized to either Chlorella (5 g/day) or placebo for a double-blinded trial with a 2-week lead-in period and a 4-week intervention period. Serum triglycerides, total cholesterol, lipoproteins, apolipoproteins and carotenoids were assessed at the beginning and the end of the trial. Results Compared with the control group, the Chlorella group exhibited remarkable changes in total cholesterol (Chlorella −1.6%; placebo 0.03%; P = 0.036), triglycerides (Chlorella −10.3%; placebo 11.9%; P = 0.002), lutein/zeaxanthin (Chlorella 89.6%; placebo −1.7%; P < 0.0001), and α-carotene (Chlorella 163.6%; placebo 15%; P < 0.0001). Improvement of serum lipids was supported by significant reductions of very low-density lipoprotein cholesterol (Chlorella −11%; placebo 11.8%; P = 0.006), apolipoprotein B (Chlorella −1.5%; placebo 1.7%; P = 0.044), non high-density lipoprotein (Chlorella −2.6%; placebo −0.5%; P = 0.032), and high-density lipoprotein/triglycerides (Chlorella 4.0%; placebo −9.5%; P = 0.023), suggesting an inhibitory effect of Chlorella on the intestinal absorption of dietary and endogenous lipids. Further, the changes of serum lipids appeared to be associated with the changes of serum carotenoids. Conclusion Daily consumption of Chlorella supplements provided the potential of health benefits reducing serum lipid risk factors, mainly triglycerides and total cholesterol, in mildly hypercholesterolemic subjects. The effect was related to carotenoid consumption. Trial registration WHO International Clinical Trials Registry Platform KCT0000259. PMID:24920270

Impact of daily Chlorella consumption on serum lipid and carotenoid profiles in mildly hypercholesterolemic adults: a double-blinded, randomized, placebo-controlled study.

PubMed

Ryu, Na Hee; Lim, Yeni; Park, Ji Eeun; Kim, Joohee; Kim, Ji Yeon; Kwon, Sung Won; Kwon, Oran

2014-06-11

High level of serum cholesterol is considered to be a major risk factor for cardiovascular disease (CVD). A double-blinded, randomized, placebo-controlled trial was performed to test the hypothesis that a daily intake of Chlorella may improve serum lipid profile through enhancement of serum carotenoid concentration in mildly hypercholesterolemic subjects. Eligible subjects (n = 63) were randomized to either Chlorella (5 g/day) or placebo for a double-blinded trial with a 2-week lead-in period and a 4-week intervention period. Serum triglycerides, total cholesterol, lipoproteins, apolipoproteins and carotenoids were assessed at the beginning and the end of the trial. Compared with the control group, the Chlorella group exhibited remarkable changes in total cholesterol (Chlorella -1.6%; placebo 0.03%; P = 0.036), triglycerides (Chlorella -10.3%; placebo 11.9%; P = 0.002), lutein/zeaxanthin (Chlorella 89.6%; placebo -1.7%; P < 0.0001), and α-carotene (Chlorella 163.6%; placebo 15%; P < 0.0001). Improvement of serum lipids was supported by significant reductions of very low-density lipoprotein cholesterol (Chlorella -11%; placebo 11.8%; P = 0.006), apolipoprotein B (Chlorella -1.5%; placebo 1.7%; P = 0.044), non high-density lipoprotein (Chlorella -2.6%; placebo -0.5%; P = 0.032), and high-density lipoprotein/triglycerides (Chlorella 4.0%; placebo -9.5%; P = 0.023), suggesting an inhibitory effect of Chlorella on the intestinal absorption of dietary and endogenous lipids. Further, the changes of serum lipids appeared to be associated with the changes of serum carotenoids. Daily consumption of Chlorella supplements provided the potential of health benefits reducing serum lipid risk factors, mainly triglycerides and total cholesterol, in mildly hypercholesterolemic subjects. The effect was related to carotenoid consumption. WHO International Clinical Trials Registry Platform KCT0000259.

Determining rates of chemical weathering in soils - Solute transport versus profile evolution

USGS Publications Warehouse

Stonestrom, David A.; White, A.F.; Akstin, K.C.

1998-01-01

SiO2 fluxes associated with contemporary solute transport in three deeply weathered granitoid profiles are compared to bulk SiO2 losses that have occurred during regolith development. Climates at the three profiles range from Mediterranean to humid to tropical. Due to shallow impeding alluvial layers at two of the profiles, and seasonally uniform rainfall at the third, temporal variations in hydraulic and chemical state variables are largely attenuated below depths of 1-2 m. This allows current SiO2 fluxes below the zone of seasonal variations to be estimated from pore-water concentrations and average hydraulic flux densities. Mean-annual SiO2 concentrations were 0.1-1.5 mM. Hydraulic conductivities for the investigated range of soil-moisture saturations ranged from 10-6 m s-1. Estimated hydraulic flux densities for quasi-steady portions of the profiles varied from 6 x 10-9 to 14 x 10-9 m s-1 based on Darcy's law and field measurements of moisture saturations and pressure heads. Corresponding fluid-residence times in the profiles ranged from 10 to 44 years. Total SiO2 losses, based on chemical and volumetric changes in the respective profiles, ranged from 19 to 110 kmoles SiO2 m-2 of land surface as a result of 0.2-0.4 Ma of chemical weathering. Extrapolation of contemporary solute fluxes to comparable time periods reproduced these SiO2 losses to about an order of magnitude. Despite the large range and non-linearity of measured hydraulic conductivities, solute transport rates in weathering regoliths can be estimated from characterization of hydrologic conditions at sufficiently large depths. The agreement suggests that current weathering rates are representative of long-term average weathering rates in the regoliths.SiO2 fluxes associated with contemporary solute transport in three deeply weathered granitoid profiles are compared to bulk SiO2 losses during regolith development. Due to shallow impeding alluvial layers at two of the profiles, and seasonally uniform rainfall at the third, temporal variations in hydraulic and chemical state variables are largely attenuated below depths of 1-2 m. Hydraulic conductivities for the investigated range of soil-moisture saturations of 10-6 m/s-1. Estimated hydraulic flux densities for quasi-steady portions of the profiles varied from 6??10-9 to 14??10-9 m/s based on Darcy's law and field measurements of moisture saturations and pressure heads.

Recovering galaxy cluster gas density profiles with XMM-Newton and Chandra

NASA Astrophysics Data System (ADS)

Bartalucci, I.; Arnaud, M.; Pratt, G. W.; Vikhlinin, A.; Pointecouteau, E.; Forman, W. R.; Jones, C.; Mazzotta, P.; Andrade-Santos, F.

2017-12-01

We examined the reconstruction of galaxy cluster radial density profiles obtained from Chandra and XMM-Newton X-ray observations, using high quality data for a sample of twelve objects covering a range of morphologies and redshifts. By comparing the results obtained from the two observatories and by varying key aspects of the analysis procedure, we examined the impact of instrumental effects and of differences in the methodology used in the recovery of the density profiles. We find that the final density profile shape is particularly robust. We adapted the photon weighting vignetting correction method developed for XMM-Newton for use with Chandra data, and confirm that the resulting Chandra profiles are consistent with those corrected a posteriori for vignetting effects. Profiles obtained from direct deprojection and those derived using parametric models are consistent at the 1% level. At radii larger than 6″, the agreement between Chandra and XMM-Newton is better than 1%, confirming an excellent understanding of the XMM-Newton PSF. Furthermore, we find no significant energy dependence. The impact of the well-known offset between Chandra and XMM-Newton gas temperature determinations on the density profiles is found to be negligible. However, we find an overall normalisation offset in density profiles of the order of 2.5%, which is linked to absolute flux cross-calibration issues. As a final result, the weighted ratios of Chandra to XMM-Newton gas masses computed at R2500 and R500 are r = 1.03 ± 0.01 and r = 1.03 ± 0.03, respectively. Our study confirms that the radial density profiles are robustly recovered, and that any differences between Chandra and XMM-Newton can be constrained to the 2.5% level, regardless of the exact data analysis details. These encouraging results open the way for the true combination of X-ray observations of galaxy clusters, fully leveraging the high resolution of Chandra and the high throughput of XMM-Newton.

Study of electromagnetic wave scattering from an inhomogeneous plasma layer using Green's function volume integral equation method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Soltanmoradi, Elmira; Shokri, Babak, E-mail: b-shokri@sbu.ac.ir; Laser and Plasma Research Institute, Shahid Beheshti University, G. C., Evin, Tehran 19839-63113

Gigahertz electromagnetic wave scattering from an inhomogeneous collisional plasma layer with bell-like and Epstein electron density distributions is studied by the Green's function volume integral equation method to find the reflectance, transmittance, and absorbance coefficients of this inhomogeneous plasma. Also, the effects of the frequency of the electromagnetic wave, plasma parameters, such as collision frequency, electron density, and plasma thickness, and the effects of the profile of the electron density on the electromagnetic wave scattering from this plasma slab are investigated. According to the results, when the electron density, collision frequency, and plasma thickness are increased, collisional absorbance is enhanced,more » and as a result, the absorbance bandwidth of plasma is broadened. Moreover, this broadening is more evident for plasma with bell-like electron density profile. Also, the bandwidth of the frequency and the range of pressure in which plasma behaves as a good reflector are determined in this article. According to the results, the bandwidth of the frequency is decreased for thicker plasma with bell-like profile, while it does not vary for a different plasma thickness with Epstein profile. Moreover, the range of the pressure is decreased for bell-like profile in comparison with Epstein profile. Furthermore, due to the sharp inhomogeneity of the Epstein profile, the coefficients of plasma that are uniform for plasma with bell-like profile are changed for plasma with Epstein profile, and some perturbations are seen.« less

Quantitative measurements of localized density variations in cylindrical tablets using X-ray microtomography.

PubMed

Busignies, Virginie; Leclerc, Bernard; Porion, Patrice; Evesque, Pierre; Couarraze, Guy; Tchoreloff, Pierre

2006-08-01

Direct compaction is a complex process that results in a density distribution inside the tablets which is often heterogeneous. Therefore, the density variations may affect the compact properties. A quantitative analysis of this phenomenon is still lacking. Recently, X-ray microtomography has been successfully used in pharmaceutical development to study qualitatively the impact of tablet shape and break-line in the density of pharmaceutical tablets. In this study, we evaluate the density profile in microcrystalline cellulose (Vivapur 12) compacts obtained at different mean porosity (ranging from 7.7% to 33.5%) using X-ray tomography technique. First, the validity of the Beer-Lambert law is studied. Then, density calibration is performed and density maps of cylindrical tablets are obtained and visualized using a process with colour-scale calibration plot which is explained. As expected, important heterogeneity in density is observed and quantified. The higher densities in peripheral region were particularly investigated and appraised in regard to the lower densities observed in the middle of the tablet. The results also underlined that in the case of pharmaceutical tablets, it is important to differentiate the mechanical properties representative of the total volume tablet and the mechanical properties that only characterize the tablet surface like the Brinell hardness measurements.

Effect of resistivity profile on current decay time of initial phase of current quench in neon-gas-puff inducing disruptions of JT-60U

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kawakami, S.; Ohno, N.; Shibata, Y.

2013-11-15

According to an early work [Y. Shibata et al., Nucl. Fusion 50, 025015 (2010)] on the behavior of the plasma current decay in the JT-60U disruptive discharges caused by the radiative collapse with a massive neon-gas-puff, the increase of the internal inductance mainly determined the current decay time of plasma current during the initial phase of current quench. To investigate what determines the increase of the internal inductance, we focus attention on the relationship between the electron temperature (or the resistivity) profile and the time evolution of the current density profile and carry out numerical calculations. As a result, wemore » find the reason of the increase of the internal inductance: The current density profile at the start of the current quench is broader than an expected current density profile in the steady state, which is determined by the temperature (or resistivity) profile. The current density profile evolves into peaked one and the internal inductance is increasing.« less

Depth profiles of oxygen precipitates in nitride-coated silicon wafers subjected to rapid thermal annealing

NASA Astrophysics Data System (ADS)

Voronkov, V. V.; Falster, R.; Kim, TaeHyeong; Park, SoonSung; Torack, T.

2013-07-01

Silicon wafers, coated with a silicon nitride layer and subjected to high temperature Rapid Thermal Annealing (RTA) in Ar, show—upon a subsequent two-step precipitation anneal cycle (such as 800 °C + 1000 °C)—peculiar depth profiles of oxygen precipitate densities. Some profiles are sharply peaked near the wafer surface, sometimes with a zero bulk density. Other profiles are uniform in depth. The maximum density is always the same. These profiles are well reproduced by simulations assuming that precipitation starts from a uniformly distributed small oxide plates originated from RTA step and composed of oxygen atoms and vacancies ("VO2 plates"). During the first step of the precipitation anneal, an oxide layer propagates around this core plate by a process of oxygen attachment, meaning that an oxygen-only ring-shaped plate emerges around the original plate. These rings, depending on their size, then either dissolve or grow during the second part of the anneal leading to a rich variety of density profiles.

Feasibility of Juno radio occultations of the Io plasma torus

NASA Astrophysics Data System (ADS)

Phipps, P. H.; Withers, P.

2016-12-01

Jupiter's magnetosphere is driven by internally produced plasma. The innermost Galilean satellite, Io, isthe dominant source of this plasma. Volcanoes on Io's surface create an atmosphere of sulfur and oxygenwhich escapes into Jupiter's magnetosphere and becomes ionized. This ionized material is trapped byJupiter's magnetic field and creates a torus of plasma centered at Io's orbital radius, called the Io plasmatorus. This torus is divided into three regions distinct in both density and composition. Densities in thistorus can be probed by spacecraft via radio occultations. A radio occultation occurs when plasma comesbetween a spacecraft and a receiver during a time when the spacecraft is sending a radio signal. The Junospacecraft, which arrived in orbit around Jupiter in July 2016, is in an orbit which will be ideal forperforming radio occultations of the Io plasma torus. We test the feasibility of using thetelecommunications system on the Juno spacecraft to perform a radio occultation. Io plasma torusdensities derived from Voyager 1 data are used in creating a model torus. Using the Ka and X-band radiofrequencies we derive vertical profiles for the total electron content of the modeled Io plasma torus. AMarkov Chain Monte Carlo fit is performed on the derived profiles to extract, for each of the torusregions, the scale height and peak total electron content. The scale height can be used to derive atemperature for the torus while the peak total electron content can be used to derive the peak electrondensity. We show that Juno radio occultation measurements of the Io plasma torus are feasible andscientifically valuable.

Groups and the Entropy Floor: XMM-Newton Observations of Two Groups

NASA Technical Reports Server (NTRS)

Mushotzky, R. F.; Figueroa-Feliciano, E.; Loewenstein, M.; Snowden, S. L.

2002-01-01

Using XMM-Newton spatially resolved X-ray imaging spectroscopy we obtain the temperature, density, entropy, gas mass, and total mass profiles for two groups of galaxies out to approximately 0.3 R(sub vir)(R(sub vir), the virial radius). Our density profiles agree well with those derived previously, and the temperature data are broadly consistent with previous results but are considerably more precise. Both of these groups are at the mass scale of 2x10(exp 13) M(solar mass), but have rather different properties. Both have considerably lower gas mass fractions at r < 0.3 R(sub vir), than the rich clusters. NGC2563, one of the least luminous groups for its X-ray temperature, has a very low gas mass fraction of approximately 0.004 inside 0.1 R(sub vir), which increases with radius. NGC4325, one of the most luminous groups at the same average temperature, has a higher gas mass fraction of 0.02. The entropy profiles and the absolute values of the entropy as a function of virial radius also differ, with NGC4325 having a value of approximately 100 keV cm(exp -2) and NGC2563 a value of approximately 300 keV cm(exp -2) at r approximately 0.1 R(sub vir). For both groups the profiles rise monotonically with radius and there is no sign of an entropy 'floor'. These results are inconsistent with pre-heating scenarios that have been developed to explain a possible entropy floor in groups, but are broadly consistent with models of structure formation that include the effects of heating and/or the cooling of the gas. The total entropy in these systems provides a strong constraint on all models of galaxy and group formation, and on the poorly defined feedback process that controls the transformation of gas into stars and thus the formation of structure in the universe.

Effects of smoking and alcohol consumption on lipid profile in male adults in northwest rural China.

PubMed

Li, X X; Zhao, Y; Huang, L X; Xu, H X; Liu, X Y; Yang, J J; Zhang, P J; Zhang, Y H

2018-04-01

To determine the individual and combined influences of smoking and alcohol consumption on lipid profile in male adults in northwest rural China. Cross-sectional study. In total, 4614 subjects were enrolled in the cross-sectional study, performed between 2008 and 2012. The present study examined males aged ≥18 years from northwest rural China (n = 707). Data on current smoking and drinking status were collected. Logistic regression was used to estimate the individual and combined influences of smoking and alcohol consumption on lipid profile. Age, ethnic group, educational background, smoking (or alcohol consumption), waist circumference, body mass index, blood pressure and fasting blood glucose were adjusted as confounders. Total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio, triglycerides (TG)/HDL-C ratio, low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio and visceral adiposity index (VAI) were significantly higher in smokers than in non-smokers, whereas HDL-C was lower in smokers. TG/HDL-C ratio, LDL-C/HDL-C ratio, TG, lipid accumulation product and VAI were significantly higher in drinkers than non-drinkers. After adjustment for confounders, significant relationships were observed between smoking status and any dyslipidemia, low HDL-C and high VAI (odds ratios [ORs]: 2.53 [95% confidence interval {CI}: 1.25-5.15], 6.13 [95% CI: 2.84-13.25] and 4.39 [95% CI: 2.02-9.54], respectively). The OR for any dyslipidaemia was 1.94 (95% CI: 1.09-3.48) for subjects who smoke and drank alcohol compared with subjects who did not smoke or drink alcohol. Abnormalities in lipid profile are correlated with smoking and alcohol consumption, which calls for intervention strategies to prevent dyslipidaemia and control risk factors for cardiovascular disease. Copyright © 2018 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

Wheat germ oil and α-lipoic acid predominantly improve the lipid profile of broiler meat.

PubMed

Arshad, Muhammad Sajid; Anjum, Faqir Muhammad; Khan, Muhammad Issa; Shahid, Muhammad

2013-11-20

In response to recent assertions that synthetic antioxidants may have the potential to cause toxic effects and to consumers' increased attention to consuming natural products, the poultry industry has been seeking sources of natural antioxidants, alone or in combination with synthetic antioxidants that are currently being used by the industry. The present study was conducted to determine the effect of α-lipoic acid, α-tocopherol, and wheat germ oil on the status of antioxidant enzymes, fatty acid profile, and serum biochemical profile of broiler blood. One-day-old (180) broiler birds were fed six different feeds varying in their antioxidant content: no addition (T1), natural α-tocopherol (wheat germ oil, T2), synthetic α-tocopherol (T3), α-lipoic acid (T4), α-lipoic acid together with natural α-tocopherol (T5), and α-lipoic acid together with synthetic α-tocopherol (T6). The composition of saturated and unsaturated fatty acids in the breast and leg meat was positively influenced by the different dietary supplements. The content of fatty acid was significantly greater in broilers receiving T2 both in breast (23.92%) and in leg (25.82%) meat, whereas lower fatty acid levels was found in broilers receiving diets containing T6 in the breast (19.57%) and leg (21.30%) meat. Serum total cholesterol (113.42 mg/dL) and triglycerides (52.29 mg/dL) were lowest in the group given natural α-tocopherol and α-lipoic acid. Wheat germ oil containing natural α-tocopherol alone or with α-lipoic acid was more effective than synthetic α-tocopherol in raising levels of antioxidant enzymes superoxide dismutase, catalase, and glutathione reductase while lowering plasma total cholesterol, low-density lipoprotein, and triglycerides and raising high-density lipoprotein and plasma protein significantly. It was concluded that the combination of wheat germ oil and α-lipoic acid is helpful in improving the lipid profile of broilers.

Vitamin E tocotrienol supplementation improves lipid profiles in chronic hemodialysis patients.

PubMed

Daud, Zulfitri A Mat; Tubie, Boniface; Sheyman, Marina; Osia, Robert; Adams, Judy; Tubie, Sharon; Khosla, Pramod

2013-01-01

Chronic hemodialysis patients experience accelerated atherosclerosis contributed to by dyslipidemia, inflammation, and an impaired antioxidant system. Vitamin E tocotrienols possess anti-inflammatory and antioxidant properties. However, the impact of dietary intervention with Vitamin E tocotrienols is unknown in this population. A randomized, double-blind, placebo-controlled, parallel trial was conducted in 81 patients undergoing chronic hemodialysis. Subjects were provided daily with capsules containing either vitamin E tocotrienol-rich fraction (TRF) (180 mg tocotrienols, 40 mg tocopherols) or placebo (0.48 mg tocotrienols, 0.88 mg tocopherols). Endpoints included measurements of inflammatory markers (C-reactive protein and interleukin 6), oxidative status (total antioxidant power and malondialdehyde), lipid profiles (plasma total cholesterol, triacylglycerols, and high-density lipoprotein cholesterol), as well as cholesteryl-ester transfer protein activity and apolipoprotein A1. TRF supplementation did not impact any nutritional, inflammatory, or oxidative status biomarkers over time when compared with the baseline within the group (one-way repeated measures analysis of variance) or when compared with the placebo group at a particular time point (independent t-test). However, the TRF supplemented group showed improvement in lipid profiles after 12 and 16 weeks of intervention when compared with placebo at the respective time points. Normalized plasma triacylglycerols (cf baseline) in the TRF group were reduced by 33 mg/dL (P=0.032) and 36 mg/dL (P=0.072) after 12 and 16 weeks of intervention but no significant improvement was seen in the placebo group. Similarly, normalized plasma high-density lipoprotein cholesterol was higher (P<0.05) in the TRF group as compared with placebo at both week 12 and week 16. The changes in the TRF group at week 12 and week 16 were associated with higher plasma apolipoprotein A1 concentration (P<0.02) and lower cholesteryl-ester transfer protein activity (P<0.001). TRF supplementation improved lipid profiles in this study of maintenance hemodialysis patients. A multi-centered trial is warranted to confirm these observations.

Constitutive melanin density is associated with higher 25-hydroxyvitamin D and potentially total body BMD in older Caucasian adults via increased sun tolerance and exposure.

PubMed

Thompson, M J W; Jones, G; Aitken, D A

2018-06-01

Greater skin pigmentation reduces dose equivalent cutaneous vitamin D3 production, potentially impacting lifetime vitamin D status and fracture risk. We show that melanin density was positively associated with 25-hydroxyvitamin D and total body bone mineral density. These relationships were partially explained by greater sun exposure due to more permissive skin phenotype. Higher cutaneous melanin reduces vitamin D3 production. This may impact lifetime vitamin D status and increase fracture risk. This study aimed to describe the relationship between spectrophotometrically determined constitutive melanin density, osteoporotic risk factors and potential intermediaries in a cohort of exclusively older Caucasian adults. One thousand seventy-two community-dwelling adults aged 50-80 years had constitutive melanin density quantified using spectrophotometry. Sun exposure, skin phenotype, non-melanoma skin cancer (NMSC) prevalence and smoking status were assessed by questionnaire. Bone mineral density (BMD), falls risk, physical activity and 25-hydroxyvitamin D were measured using DXA, the short form Physiological Profile Assessment, pedometer and radioimmunoassay, respectively. Higher melanin density was independently associated with greater ability to tan (RR = 1.27, p < 0.001), less propensity to sunburn (RR = 0.92, p < 0.001), fewer lifetime sunburns (RR = 0.94, p = 0.01), current smoking (RR = 1.41, p < 0.001), female sex (RR = 1.24, p < 0.001) and less photodamage (RR = 0.98, p = 0.01). The associations between melanin density and sun exposure (RR = 1.05-1.11, p < 0.001-0.01), sun protection behaviours (RR = 0.89, p < 0.001) and NMSC prevalence (RR = 0.75, p = 0.001) were no longer significant after taking into account skin phenotype and sun exposure, respectively. 25-Hydroxyvitamin D was strongly associated with higher melanin density (β = 1.71-2.05, p = 0.001). The association between melanin density and total body BMD (β = 0.007, p = 0.04) became non-significant after adjustment for 25-hydroxyvitamin D. There was no association between melanin density and physical activity, falls risk or BMD at other sites. Our data support a model of higher constitutive melanin density underpinning a less photosensitive skin phenotype, permitting greater sun exposure with fewer sequelae and yielding higher 25-hydroxyvitamin D and, potentially, total body BMD.

Atmospheric constituent density profiles from full disk solar occultation experiments

NASA Technical Reports Server (NTRS)

Lumpe, J. D.; Chang, C. S.; Strickland, D. J.

1991-01-01

Mathematical methods are described which permit the derivation of the number of density profiles of atmospheric constituents from solar occultation measurements. The algorithm is first applied to measurements corresponding to an arbitrary solar-intensity distribution to calculate the normalized absorption profile. The application of Fourier transform to the integral equation yields a precise expression for the corresponding number density, and the solution is employed with the data given in the form of Laguerre polynomials. The algorithm is employed to calculate the results for the case of uniform distribution of solar intensity, and the results demonstrate the convergence properties of the method. The algorithm can be used to effectively model representative model-density profiles with constant and altitude-dependent scale heights.

Electronic properties of Laves phase ZrFe{sub 2} using Compton spectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhatt, Samir, E-mail: sameerbhatto11@gmail.com; Kumar, Kishor; Ahuja, B. L.

First-ever experimental Compton profile of Laves phase ZrFe{sub 2}, using indigenous 20 Ci {sup 137}Cs Compton spectrometer, is presented. To analyze the experimental electron momentum density, we have deduced the theoretical Compton profiles using density functional theory (DFT) and hybridization of DFT and Hartree-Fock scheme within linear combination of atomic orbitals (LCAO) method. The energy bands and density of states are also calculated using LCAO prescription. The theoretical profile based on local density approximation gives a better agreement with the experimental profile than other reported schemes. The present investigations validate the inclusion of correlation potential of Perdew-Zunger in predicting themore » electronic properties of ZrFe{sub 2}.« less

A Numerical Fit of Analytical to Simulated Density Profiles in Dark Matter Haloes

NASA Astrophysics Data System (ADS)

Caimmi, R.; Marmo, C.; Valentinuzzi, T.

2005-06-01

Analytical and geometrical properties of generalized power-law (GPL) density profiles are investigated in detail. In particular, a one-to-one correspondence is found between mathematical parameters (a scaling radius, r_0, a scaling density, rho_0, and three exponents, alpha, beta, gamma), and geometrical parameters (the coordinates of the intersection of the asymptotes, x_C, y_C, and three vertical intercepts, b, b_beta, b_gamma, related to the curve and the asymptotes, respectively): (r_0,rho_0,alpha,beta,gamma) <--> (x_C,y_C,b,b_beta,b_gamma). Then GPL density profiles are compared with simulated dark haloes (SDH) density profiles, and nonlinear least-absolute values and least-squares fits involving the above mentioned five parameters (RFSM5 method) are prescribed. More specifically, the sum of absolute values or squares of absolute logarithmic residuals, R_i= log rhoSDH(r_i)-log rhoGPL(r_i), is evaluated on 10^5 points making a 5- dimension hypergrid, through a few iterations. The size is progressively reduced around a fiducial minimum, and superpositions on nodes of earlier hypergrids are avoided. An application is made to a sample of 17 SDHs on the scale of cluster of galaxies, within a flat LambdaCDM cosmological model (Rasia et al. 2004). In dealing with the mean SDH density profile, a virial radius, rvir, averaged over the whole sample, is assigned, which allows the calculation of the remaining parameters. Using a RFSM5 method provides a better fit with respect to other methods. The geometrical parameters, averaged over the whole sample of best fitting GPL density profiles, yield (alpha,beta,gamma) approx(0.6,3.1,1.0), to be compared with (alpha,beta,gamma)=(1,3,1), i.e. the NFW density profile (Navarro et al. 1995, 1996, 1997), (alpha,beta,gamma)=(1.5,3,1.5) (Moore et al. 1998, 1999), (alpha,beta,gamma)=(1,2.5,1) (Rasia et al. 2004); and, in addition, gamma approx 1.5 (Hiotelis 2003), deduced from the application of a RFSM5 method, but using a different definition of scaled radius, or concentration; and gamma approx 1.2-1.3 deduced from more recent high-resolution simulations (Diemand et al. 2004, Reed et al. 2005). No evident correlation is found between SDH dynamical state (relaxed or merging) and asymptotic inner slope of the fitting logarithmic density profile or (for SDH comparable virial masses) scaled radius. Mean values and standard deviations of some parameters are calculated, and in particular the decimal logarithm of the scaled radius, xivir, reads < log xivir >=0.74 and sigma_s log xivir=0.15-0.17, consistent with previous results related to NFW density profiles. It provides additional support to the idea, that NFW density profiles may be considered as a convenient way to parametrize SDH density profiles, without implying that it necessarily produces the best possible fit (Bullock et al. 2001). A certain degree of degeneracy is found in fitting GPL to SDH density profiles. If it is intrinsic to the RFSM5 method or it could be reduced by the next generation of high-resolution simulations, still remains an open question.

First Ionospheric Results From the MAVEN Radio Occultation Science Experiment (ROSE)

NASA Astrophysics Data System (ADS)

Withers, Paul; Felici, M.; Mendillo, M.; Moore, L.; Narvaez, C.; Vogt, M. F.; Jakosky, B. M.

2018-05-01

Radio occultation observations of the ionosphere of Mars can span the full vertical extent of the ionosphere, in contrast to in situ measurements that rarely sample the main region of the ionosphere. However, most existing radio occultation electron density profiles from Mars were acquired without clear context for the solar forcing or magnetospheric conditions, which presents challenges for the interpretation of these profiles. Here we present 48 ionospheric electron density profiles acquired by the Mars Atmosphere and Volatile EvolutioN mission (MAVEN) Radio Occultation Science Experiment (ROSE) from 5 July 2016 to 27 June 2017 at solar zenith angles of 54° to 101°. Latitude coverage is excellent, and comprehensive context for the interpretation of these profiles is provided by other MAVEN instruments. The profiles show a 9-km increase in ionospheric peak altitude in January 2017 that is associated with a lower atmospheric dust storm, variations in electron densities in the M1 layer that cannot be explained by variations in the solar soft X-ray flux, and topside electron densities that are larger in strongly magnetized regions than in weakly magnetized regions. MAVEN Radio Occultation Science Experiment electron density profiles are publicly available on the NASA Planetary Data System.

Denitrification potential of riparian soils in relation to multiscale spatial environmental factors: a case study of a typical watershed, China.

PubMed

Wei, Jianbing; Feng, Hao; Cheng, Quanguo; Gao, Shiqian; Liu, Haiyan

2017-02-01

The objective of this study was to test the hypothesis that environmental regulators of riparian zone soil denitrification potential differ according to spatial scale within a watershed; consequently, a second objective was to provide spatial strategies for conserving and restoring the purification function of runoff in riparian ecosystems. The results show that soil denitrification in riparian zones was more heterogeneous at the profile scale than at the cross-section and landscape scales. At the profile scale, biogeochemical factors (including soil total organic carbon, total nitrogen, and nitrate-nitrogen) were the major direct regulators of the spatial distribution of soil denitrification enzyme activity (DEA). At the cross-section scale, factors included distance from river bank and vegetation density, while landscape-scale factors, including topographic index, elevation, and land use types, indirectly regulated the spatial distribution of DEA. At the profile scale, soil DEA was greatest in the upper soil layers. At the cross-section scale, maximum soil DEA occurred in the mid-part of the riparian zone. At the landscape scale, soil DEA showed an increasing trend towards downstream sites, except for those in urbanized areas.

Loss of body weight and fat and improved lipid profiles in obese rats fed apple pomace or apple juice concentrate.

PubMed

Cho, Kyung-Dong; Han, Chan-Kyu; Lee, Bog-Hieu

2013-09-01

The purpose of this study was to investigate the influence of apple pomace (AP) and apple juice concentrate (AC) supplementation on body weight and fat loss as well as lipid metabolism in obese rats fed a high-fat diet. Diet-induced obese rats were assigned to three groups (n=8 for each group): high fat diet (HFD) control, HFD containing 10% (w/w) AP, and HFD containing 10% (w/w) AC. There was also a normal diet group (n=8). After 5 weeks, body weight gain, adipose tissue weight, serum and hepatic lipid profiles, liver morphology, and adipocyte size were measured. Body weight gain, white adipose tissue (WAT) weight, serum total cholesterol, low-density lipoprotein cholesterol and triglyceride concentrations, epididymal adipocyte size, and lesion scores were significantly lower and serum high-density lipoprotein cholesterol concentration and brown adipose tissue weights were significantly higher in the AP and AC groups compared with the HFD group. In addition, atherogenic indices in the AP and AC groups were significantly lower than in the HFD group. These results indicate that supplementing apple products such as AP and AC may help suppress body weight and WAT gain, as well as improve lipid profiles in diet-induced obese rats.

Environmental Variations in the Atomic and Molecular Gas Radial Profiles of Nearby Spiral Galaxies

NASA Astrophysics Data System (ADS)

Mok, Angus; Wilson, Christine; JCMT Nearby Galaxies Legacy Survey

2017-01-01

We present an analysis of the radial profiles of a sample of 43 HI-flux selected spiral galaxies from the Nearby Galaxies Legacy Survey (NGLS) with resolved James Clerk Maxwell Telescope (JCMT) CO J= 3-2 and/or Very Large Array (VLA) HI maps. Comparing the Virgo and non-Virgo populations, we confirm that the HI disks are truncated in the Virgo sample, even for these relatively HI-rich galaxies. On the other hand, the H2 distribution is enhanced for Virgo galaxies near their centres, resulting in higher H2 to HI ratios and steeper H2 and total gas radial profiles. This is likely due to the effects of moderate ram pressure stripping in the cluster environment, which would preferentially remove low density gas in the outskirts while enhancing higher density gas near the centre. Combined with Hα star formation rate data, we find that the star formation efficiency (SFR/H2) is relatively constant with radius for both samples, but Virgo galaxies have a ˜40% lower star formation efficiency than non-Virgo galaxies. These results suggest that the environment of spiral galaxies can play an important role in the formation of molecular gas and the star formation process.

Loss of Body Weight and Fat and Improved Lipid Profiles in Obese Rats Fed Apple Pomace or Apple Juice Concentrate

PubMed Central

Cho, Kyung-Dong; Han, Chan-Kyu

2013-01-01

Abstract The purpose of this study was to investigate the influence of apple pomace (AP) and apple juice concentrate (AC) supplementation on body weight and fat loss as well as lipid metabolism in obese rats fed a high-fat diet. Diet-induced obese rats were assigned to three groups (n=8 for each group): high fat diet (HFD) control, HFD containing 10% (w/w) AP, and HFD containing 10% (w/w) AC. There was also a normal diet group (n=8). After 5 weeks, body weight gain, adipose tissue weight, serum and hepatic lipid profiles, liver morphology, and adipocyte size were measured. Body weight gain, white adipose tissue (WAT) weight, serum total cholesterol, low-density lipoprotein cholesterol and triglyceride concentrations, epididymal adipocyte size, and lesion scores were significantly lower and serum high-density lipoprotein cholesterol concentration and brown adipose tissue weights were significantly higher in the AP and AC groups compared with the HFD group. In addition, atherogenic indices in the AP and AC groups were significantly lower than in the HFD group. These results indicate that supplementing apple products such as AP and AC may help suppress body weight and WAT gain, as well as improve lipid profiles in diet-induced obese rats. PMID:23909905

Variability in spatial and temporal occurrence of presettlement and settlement-stage fishes associated with shallow reefs.

PubMed

Pattrick, P; Strydom, N A

2017-03-01

Presettlement and settlement-stage fishes were studied in a large, log-spiral bay in temperate South Africa. The aim was to describe the assemblage composition, density and distribution associated with four types of habitats common to the bay: high profile reef, low profile reef, reef-associated sand and open sand spatially separated from reef. Samples were collected with both a plankton ring net and a light trap at each habitat type as part of a mixed-method approach. A total of 4084 presettlement and settlement-stage fishes belonging to 31 teleost families and 84 species were captured. Reef-associated sand and open sand habitats yielded higher species richness and diversity than the high and low-profile reef habitats. Engraulidae, Gobiidae, Clupeidae and Cynoglossidae were the dominant fish families captured with the ring net, while Engraulidae, Clupeidae, Carangidae and Clinidae were captured with the light trap. A temporal difference in the abundance of presettlement fishes occurred between the sampling periods with highest values recorded during the summer settlement period. Habitat type together with associated physico-chemical variables played a pivotal role in determining presettlement fish species composition, density and distribution across habitat types. © 2016 The Fisheries Society of the British Isles.

The correlation between the sizes of globular cluster systems and their host dark matter haloes

NASA Astrophysics Data System (ADS)

Hudson, Michael J.; Robison, Bailey

2018-07-01

The sizes of entire systems of globular clusters (GCs) depend not only on the formation and destruction histories of the GCs themselves but also on the assembly, merger, and accretion history of the dark matter (DM) haloes that they inhabit. Recent work has shown a linear relation between total mass of GCs in the GC system and the mass of its host DM halo, calibrated from weak lensing. Here, we extend this to GC system sizes, by studying the radial density profiles of GCs around galaxies in nearby galaxy groups. We find that radial density profiles of the GC systems are well fit with a de Vaucouleurs profile. Combining our results with those from the literature, we find tight relationship (˜0.2 dex scatter) between the effective radius of the GC system and the virial radius (or mass) of its host DM halo, for haloes with masses greater than ˜1012 M⊙. The steep non-linear dependence of this relationship (R_{ {e, GCS}} ∝ R_{200}^{2.5 - 3} ∝ M_{200}^{0.8 - 1}) is currently not well understood, but is an important clue regarding the assembly history of DM haloes and of the GC systems that they host.

The mass discrepancy acceleration relation in a ΛCDM context

NASA Astrophysics Data System (ADS)

Di Cintio, Arianna; Lelli, Federico

2016-02-01

The mass discrepancy acceleration relation (MDAR) describes the coupling between baryons and dark matter (DM) in galaxies: the ratio of total-to-baryonic mass at a given radius anticorrelates with the acceleration due to baryons. The MDAR has been seen as a challenge to the Λ cold dark matter (ΛCDM) galaxy formation model, while it can be explained by Modified Newtonian Dynamics. In this Letter, we show that the MDAR arises in a ΛCDM cosmology once observed galaxy scaling relations are taken into account. We build semi-empirical models based on ΛCDM haloes, with and without the inclusion of baryonic effects, coupled to empirically motivated structural relations. Our models can reproduce the MDAR: specifically, a mass-dependent density profile for DM haloes can fully account for the observed MDAR shape, while a universal profile shows a discrepancy with the MDAR of dwarf galaxies with M⋆ < 109.5 M⊙, a further indication suggesting the existence of DM cores. Additionally, we reproduce slope and normalization of the baryonic Tully-Fisher relation (BTFR) with 0.17 dex scatter. These results imply that in ΛCDM (I) the MDAR is driven by structural scaling relations of galaxies and DM density profile shapes, and (II) the baryonic fractions determined by the BTFR are consistent with those inferred from abundance-matching studies.

Chinese lacto-vegetarian diet exerts favorable effects on metabolic parameters, intima-media thickness, and cardiovascular risks in healthy men.

PubMed

Yang, Shu-Yu; Li, Xue-Jun; Zhang, Wei; Liu, Chang-Qin; Zhang, Hui-Jie; Lin, Jin-Rong; Yan, Bing; Yu, Ya-Xin; Shi, Xiu-Lin; Li, Can-Dong; Li, Wei-Hua

2012-06-01

To investigate whether the Chinese lacto-vegetarian diet has protective effects on metabolic and cardiovascular disease (CVD). One hundred sixty-nine healthy Chinese lacto-vegetarians and 126 healthy omnivore men aged 21-76 years were enrolled. Anthropometric indexes, lipid profile, insulin sensitivity, pancreatic β cell function, and intima-media thickness (IMT) of carotid arteries were assessed and compared. Cardiovascular risk points and probability of developing CVD in 5-10 years in participants aged 24-55 years were calculated. Compared with omnivores, lacto-vegetarians had remarkably lower body mass index, systolic and diastolic blood pressure, and serum levels of triglyceride, total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, γ-glutamyl transferase, serum creatinine, uric acid, fasting blood glucose, as well as lower total cholesterol/high-density lipoprotein cholesterol ratio. Vegetarians also had higher homeostasis model assessment β cell function and insulin secretion index and thinner carotid IMT than the omnivores did. These results corresponded with lower cardiovascular risk points and probability of developing CVD in 5-10 years in vegetarians 24-55 years old. In healthy Chinese men, the lacto-vegetarian diet seems to exert protective effects on blood pressure, lipid profiles, and metabolic parameters and results in significantly lower carotid IMT. Lower CVD risks found in vegetarians also reflect the beneficial effect of the Chinese lacto-vegetarian diet.

The relationship between adenovirus-36 seropositivity, obesity and metabolic profile in Turkish children and adults.

PubMed

Karamese, M; Altoparlak, U; Turgut, A; Aydogdu, S; Karamese, S Aksak

2015-12-01

Obesity potentially arising from viral infection is known as 'infectobesity'. The latest reports suggest that adenovirus-36 (Adv36) is related to obesity in adults and children. Our aim was not only to determine the Adv36 seropositivity in both obese and non-obese children and adults, but also to investigate correlations between antibody positivity and serum lipid profiles. Both Adv36 positivity and tumour-necrosis-factor-alpha, leptin and interleukin-6 levels were detected in blood samples collected from 146 children and 130 adults by ELISA. Fasting plasma triglycerides, total cholesterol and low-density lipoprotein levels were also measured. Adv36 positivity was determined to be 27·1% and 6% in obese and non-obese children and 17·5% and 4% in obese and non-obese adults, respectively. There was no difference with regard to total cholesterol, low-density lipoprotein, triglyceride, tumour-necrosis-factor-alpha and interleukin-6 levels (P > 0·05). However, there was a significant difference between groups in terms of leptin levels (P < 0·05). We determined the prevalence of Adv36 positivity in obese children and adults. Our results showed that Adv36 may be an obesity agent for both adults and children, parallel with current literature data. However, the available data on a possible relationship between Adv36 infection and obesity both in children and adults do not completely solve the problem.

The effect of exemestane, anastrozole, and tamoxifen on lipid profiles in Japanese postmenopausal early breast cancer patients: final results of National Surgical Adjuvant Study BC 04, the TEAM Japan sub-study.

PubMed

Hozumi, Y; Suemasu, K; Takei, H; Aihara, T; Takehara, M; Saito, T; Ohsumi, S; Masuda, N; Ohashi, Y

2011-08-01

In this Tamoxifen Exemestane Adjuvant Multinational Japan sub-study, we evaluated the time course of changes in serum lipids in postmenopausal women with hormone-sensitive early breast cancer treated with exemestane, anastrozole, or tamoxifen for postoperative adjuvant therapy. A total of 154 breast cancer patients were assigned to receive exemestane, anastrozole, or tamoxifen in this randomized open-label study. Serum lipid parameters including triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured during 1 year of treatment. TC and LDL-C rapidly decreased in patients treated with tamoxifen at 3 months. Compared with anastrozole and exemestane patients, TC and LDL-C were significantly lower at all assessment time points in tamoxifen patients (P < 0.05). TG increased in tamoxifen patients; it was significantly higher compared with exemestane patients at all assessment time points (P < 0.05). HDL-C slightly decreased in exemestane patients; it was significantly lower compared with anastrozole patients at 3 months and 1 year (P = 0.0179 and 0.0013, respectively). Changes of lipid profiles in Japanese postmenopausal women treated with tamoxifen were relatively favorable, while exemestane and anastrozole had no clinically significant effect on the serum lipids.

Coconut oil consumption and cardiovascular risk factors in humans.

PubMed

Eyres, Laurence; Eyres, Michael F; Chisholm, Alexandra; Brown, Rachel C

2016-04-01

Coconut oil is being heavily promoted as a healthy oil, with benefits that include support of heart health. To assess the merits of this claim, the literature on the effect of coconut consumption on cardiovascular risk factors and outcomes in humans was reviewed. Twenty-one research papers were identified for inclusion in the review: 8 clinical trials and 13 observational studies. The majority examined the effect of coconut oil or coconut products on serum lipid profiles. Coconut oil generally raised total and low-density lipoprotein cholesterol to a greater extent than cis unsaturated plant oils, but to a lesser extent than butter. The effect of coconut consumption on the ratio of total cholesterol to high-density lipoprotein cholesterol was often not examined. Observational evidence suggests that consumption of coconut flesh or squeezed coconut in the context of traditional dietary patterns does not lead to adverse cardiovascular outcomes. However, due to large differences in dietary and lifestyle patterns, these findings cannot be applied to a typical Western diet. Overall, the weight of the evidence from intervention studies to date suggests that replacing coconut oil with cis unsaturated fats would alter blood lipid profiles in a manner consistent with a reduction in risk factors for cardiovascular disease. © The Author(s) 2016. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

RECOZ data reduction and analysis: Programs and procedures

NASA Technical Reports Server (NTRS)

Reed, E. I.

1984-01-01

The RECOZ data reduction programs transform data from the RECOZ photometer to ozone number density and overburden as a function of altitude. Required auxiliary data are the altitude profile versus time and for appropriate corrections to the ozone cross sections and scattering effects, air pressure and temperature profiles. Air temperature and density profiles may also be used to transform the ozone density versus geometric altitude to other units, such as to ozone partial pressure or mixing ratio versus pressure altitude. There are seven programs used to accomplish this: RADAR, LISTRAD, RAW OZONE, EDIT OZONE, MERGE, SMOOTH, and PROFILE.

Relative secular variations of the geomagnetic field along the Zgorzelec-Wiżajny profile, Poland

NASA Astrophysics Data System (ADS)

Wojas, Anna; Grabowska, Teresa; Mikołajczak, Mateusz

2018-03-01

The paper presents results of the study on relative secular variations of total magnetic intensity (TMI) of the geomagnetic field along the 700 km long profile crossing the area of Poland. Surveys were carried out at annual intervals between 1966 and 2016 (50 measurement series), in 31 survey sites (secular points) separated by about 22 km. The studied profile of the SW-NE direction, called Zgorzelec-Wiżajny (Z-W), crosses large parts of the main tectonic units of Europe, namely the Palaeozoic Platform of Central and Western Europe (PLZ) and the East European Craton (EEC), connected by the Teisseyre-Tornquist Zone (TTZ). Using the original methodology of analysis of measured data, reduced to the values of geomagnetic field recorded at the Central Geophysical Observatory in Belsk, the relative secular variations of TMI with the magnetic anomalies (ΔT) and the terrestrial heat flow density (Q) were graphically presented.

A Plasma Diagnostic Set for the Study of a Variable Specific Impulse Magnetoplasma Rocket

NASA Astrophysics Data System (ADS)

Squire, J. P.; Chang-Diaz, F. R.; Bengtson Bussell, R., Jr.; Jacobson, V. T.; Wootton, A. J.; Bering, E. A.; Jack, T.; Rabeau, A.

1997-11-01

The Advanced Space Propulsion Laboratory (ASPL) is developing a Variable Specific Impulse Magnetoplasma Rocket (VASIMR) using an RF heated magnetic mirror operated asymmetrically. We will describe the initial set of plasma diagnostics and data acquisition system being developed and installed on the VASIMR experiment. A U.T. Austin team is installing two fast reciprocating probes: a quadruple Langmuir and a Mach probe. These measure electron density and temperature profiles, electrostatic plasma fluctuations, and plasma flow profiles. The University of Houston is developing an array of 20 highly directional Retarding Potential Analyzers (RPA) for measuring ion energy distribution function profiles in the rocket plume, giving a measurement of total thrust. We have also developed a CAMAC based data acquisition system using LabView running on a Power Macintosh communicating through a 2 MB/s serial highway. We will present data from initial plasma operations and discuss future diagnostic development.

Effects of growth hormone and testosterone therapy on aerobic and anaerobic fitness, body composition and lipoprotein profile in middle-aged men.

PubMed

Zając, Adam; Wilk, Michał; Socha, Teresa; Maszczyk, Adam; Chycki, Jakub

2014-01-01

Andropause and aging are associated with neuroendocrine dysfunctions. Growth hormone and testosterone play a significant role in several processes affecting adaptation and thereby also everyday functioning. The aim of this research project was to evaluate the effects of recombinant human growth hormone and testosterone enanthate injections on body mass and body composition, aerobic and anaerobic fitness and lipid profile in middle-aged men. The research group was comprised of 14 men aged 45 - 60 years. Two series of laboratory analyses were performed. Independent tests were carried out at baseline and after 12 weeks of the experiment. The data were analyzed using Statistica 9.1 software. A two-way repeated measures ANOVA revealed a statistically significant effect of the intervention programme on fat-free mass (η(2)=0.34), total body fat (η(2)=0.79), total cholesterol (η(2)=0.30), high-density lipoprotein cholesterol (η(2)=0.31), low-density lipoprotein cholesterol (η(2)=0.42), triglyceride (η(2)=0.28), testosterone (η(2)=0.52), insulin-like growth factor 1 (η(2)=0.47) and growth hormone (η(2)=0.63). Furthermore, ANOVA revealed a statistically significant effect of the rhGH and T treatment on maximal oxygen uptake (η(2)=0.63), anaerobic threshold (η(2)=0.61) and maximal work rate (η(2)=0.53). It should be emphasized that the lipid profile was affected not only by rhGH+T replacement therapy, but also by the prescribed physical activity programme. The strength and endurance fitness programme alone did not cause significant changes in body mass and composition, nor the anaerobic and aerobic capacity. On the other hand, the rhGH=T treatment stimulated these changes significantly.

Dietary tartary buckwheat intake attenuates insulin resistance and improves lipid profiles in patients with type 2 diabetes: a randomized controlled trial.

PubMed

Qiu, Ju; Liu, Yanping; Yue, Yanfen; Qin, Yuchang; Li, Zaigui

2016-12-01

Tartary buckwheat (TB) is rich in protein, dietary fiber, and flavonoids and has been reported to affect type 2 diabetes mellitus (T2DM) in animal experiments, but limited information on the benefit of TB as a whole food in T2DM patients is available. Thus, we tested the hypothesis that a daily replacement of a portion of the staple food with TB will improve risk factors of T2DM, including fasting glucose, insulin resistance, and lipid profile. In a parallel, randomized, open-label, controlled trial, 165 T2DM patients were randomly assigned to a control diet group (DC group; systematic diet plans and intensive nutritional education) or a TB intervention group (TB group; daily replacement of a portion of staple food with TB food). Blood samples and diet information were collected at baseline and after 4 weeks of intervention. The TB group decreased fasting insulin (2.46-2.39 Ln mU/L), total cholesterol (5.08-4.79 mmol/L), and low-density lipoprotein cholesterol (3.00-2.80 mmol/L) compared with the DC group at 4 weeks (P<.05). No significant differences in blood glucose or glycated hemoglobin levels were noted between the TB and DC groups. In addition, subgroup analyses based on daily TB intake dose showed a reduction in insulin, total cholesterol, and low-density lipoprotein cholesterol, but also insulin resistance was observed when TB intake dose was greater than 110 g/d. These results support the hypothesis that TB may improve insulin resistance and lipid profile in T2DM patients. Copyright © 2016 Elsevier Inc. All rights reserved.

Associated liver enzymes with hyperlipidemic profile in type 2 diabetes patients.

PubMed

Al-Jameil, Noura; Khan, Farah A; Arjumand, Sadia; Khan, Mohammad F; Tabassum, Hajera

2014-01-01

Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia and is associated with dyslipidemia and disturbed liver function. Aim of the present work is to assess the liver enzymes and to find its association with hyperlipidemic profile in T2DM. Total of 157 subjects were studied and divided into two groups; diabetes (n=81) and non-diabetes (n=76). Various biochemical parameters like fasting glucose, post prandial glucose, HbA1c, total cholesterol (TC), triglycerides (Tg), high density lipoprotein cholesterol (HDL-C), alanine amino transferase (ALT), aspartate amino transferase (AST) and gamma-glutamyl transferase (GGT) were analyzed by ROCHE module Cobas 6000 (C501 & C601) analyzer, kits were procured by ROCHE diagnostics. Low density lipoprotein cholesterol (LDL-C) was estimated by Freidwald's formula. Statistical analysis was performed by applying student t test and Pearson's correlation coefficient, at 0.0001 and 0.05 level of significance, respectively. All the glycemic control parameters, lipid profile parameters except HDL-C and liver enzymes were found increased in diabetes group and significantly differ from non-diabetes group (p>0.0001). ALT showed significant positive correlation with fasting glucose, post prandial glucose, HbA1c, TC, Tg, LDL-C and GGT at p>0.05. AST showed very weak relation with all parameters while GGT was positively associated with fasting glucose, post prandial glucose, HbA1c, TC, Tg, LDL-C and ALT at p>0.05. In conclusion, T2DM incline to elevate liver enzymes, especially ALT and GGT were of significance. Routine screening of ALT and GGT in T2DM patients may assists early detection of liver abnormalities and to arrest the progress of disease.

Association of Spicy Food Consumption Frequency with Serum Lipid Profiles in Older People in China.

PubMed

Yu, K; Xue, Y; He, T; Guan, L; Zhao, A; Zhang, Y

2018-01-01

There has been recent interest in spicy foods and their bioactive ingredients for cardiovascular health. This study aims to explore relationship between spicy food consumption frequency and serum lipid profiles in a cross-sectional sample of older Chinese from China Health and Nutrition Survey (CHNS). A total of 1549 participant aged 65 years and above from CHNS 2009 were included in the analysis. Information on spicy food consumption was obtained using a questionnaire survey and 24h dietary recalls over three consecutive days combined with weighted food inventory. Fasting blood samples were analyzed for total cholesterol (TC), triglycerides, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (apoA1) and apolipoprotein B (apoB). Correlations between spicy food consumption frequency and serum lipid profiles were evaluated by multivariate linear regression models. The result shows a significant positive association between frequency of spicy food consumption estimated by the frequency question and daily spicy food intake calculated from 24h recall. After adjustment for potential lifestyle and dietary confounding factors, men with higher frequency of spicy food consumption showed higher apoA1 level, and lower ratio of LDL-C/apoB (p for trend <0.05). For female, frequency of spicy food consumption was significantly associated with TC, LDL-C, apoB, LDL-C/HDL-C, and apoB/apoA1 in an inverse manner, and positively correlated with apoA1 level (p for trend <0.05). In this study with Chinese aged 65y and above, increased spicy food consumption frequency may favorably associated with some risk factors for cardiovascular diseases.

Relationship between the burden of major periodontal bacteria and serum lipid profile in a cross-sectional Japanese study.

PubMed

Choi, Youn-Hee; Kosaka, Takayuki; Ojima, Miki; Sekine, Shinichi; Kokubo, Yoshihiro; Watanabe, Makoto; Miyamoto, Yoshihiro; Ono, Takahiro; Amano, Atsuo

2018-05-04

The association of periodontal bacteria with lipid profile alteration remains largely unknown, although it has been suggested that chronic periodontitis increases the atherosclerotic risk. This cross-sectional study investigated the relationship between the prevalence and total burden of periodontal bacteria and serum lipid profile. Saliva from enrolled participants was collected to detect 4 major periodontal bacteria (Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, and Prevotella intermedia) using Polymerase Chain Reaction method. High-density lipoprotein (HDL) cholesterol, triglycerides (TG), and low-density lipoprotein cholesterol were assessed using blood samples. We compared the averages of each lipid in association with the prevalence of each bacterial species, their burden (low, moderate, and high), and the combination of bacterial burden and periodontal status, defined as periodontitis, using the Community Periodontal Index, after adjustment for other potential confounding factors, by employing general linear models with least square means. A total of 385 Japanese individuals (176 men, 209 women; mean age 69.2 years) were enrolled. The number of bacterial species and their co-existence with periodontitis were significantly related to a decrease in HDL (p for trend < 0.01) and increase in TG (p for trend = 0.04). The adjusted mean HDL levels (mg/dL) in individuals with low, moderate, and high levels of bacterial species were 66.1, 63.0, and 58.9, respectively, and those in the 6 groups defined by combination of the two factors were 67.9, 64.6, 64.3, 65.4, 61.5, and 54.7, respectively. Periodontal bacterial burden is suggested to be independently involved in lowering serum HDL level. Our findings suggest that bacterial tests in a clinical setting could be a useful approach for predicting the risk of HDL metabolism dysregulation.

2D electron density profile measurement in tokamak by laser-accelerated ion-beam probe.

PubMed

Chen, Y H; Yang, X Y; Lin, C; Wang, L; Xu, M; Wang, X G; Xiao, C J

2014-11-01

A new concept of Heavy Ion Beam Probe (HIBP) diagnostic has been proposed, of which the key is to replace the electrostatic accelerator of traditional HIBP by a laser-driven ion accelerator. Due to the large energy spread of ions, the laser-accelerated HIBP can measure the two-dimensional (2D) electron density profile of tokamak plasma. In a preliminary simulation, a 2D density profile was reconstructed with a spatial resolution of about 2 cm, and with the error below 15% in the core region. Diagnostics of 2D density fluctuation is also discussed.

Analysis of FORTE data to extract ionospheric parameters

NASA Astrophysics Data System (ADS)

Roussel-Dupré, Robert A.; Jacobson, Abram R.; Triplett, Laurie A.

2001-01-01

The ionospheric transfer function is derived for a spherically symmetric ionosphere with an arbitrary radial electron density profile in the limit where the radio frequencies of interest ω are much larger than the plasma frequency ωpe. An expansion of the transfer function to second order in the parameter X (= ω2pe/ω2) is carried out. In this limit the dispersive properties of the ionosphere are manifested as a frequency-dependent time of arrival that includes quadratic, cubic, and quartic terms in 1/ω. The coefficients of these terms are related to the total electron content (TEC) along the slant path from transmitter to receiver, the product of TEC and the longitudinal magnetic field strength along the slant path, and refractive bending and higher-order electron density profile effects, respectively. By fitting the time of arrival versus frequency of a transionospheric signal to a polynomial in 1/ω it is possible to extract the TEC, the longitudinal magnetic field strength, the peak electron density, and an effective thickness for the ionosphere. This exercise was carried out for a number of transionospheric pulses measured in the VHF by the FORTE satellite receiver and generated by the Los Alamos Portable Pulser. The results are compared with predictions derived from the International Reference Ionosphere and the United States Geological Survey geomagnetic field model.

Measured density of copper atoms in the ground and metastable states in argon magnetron discharge correlated with the deposition rate

NASA Astrophysics Data System (ADS)

Naghshara, H.; Sobhanian, S.; Khorram, S.; Sadeghi, N.

2011-01-01

In a dc-magnetron discharge with argon feed gas, densities of copper atoms in the ground state Cu(2S1/2) and metastable state Cu*(2D5/2) were measured by the resonance absorption technique, using a commercial hollow cathode lamp as light source. The operating conditions were 0.3-14 µbar argon pressure and 10-200 W magnetron discharge power. The deposition rate of copper in a substrate positioned at 18 cm from the target was also measured with a quartz microbalance. The gas temperature, in the range 300-380 K, was deduced from the emission spectral profile of N2(C 3Πu - B 3Πg) 0-0 band at 337 nm when trace of nitrogen was added to the argon feed gas. The isotope-shifts and hyperfine structures of electronic states of Cu have been taken into account to deduce the emission and absorption line profiles, and hence for the determination of atoms' densities from the measured absorption rates. To prevent error in the evaluation of Cu density, attributed to the line profile distortion by auto-absorption inside the lamp, the lamp current was limited to 5 mA. Density of Cu(2S1/2) atoms and deposition rate both increased with the enhanced magnetron discharge power. But at fixed power, the copper density augmented with argon pressure whereas the deposition rate followed the opposite trend. Whatever the gas pressure, the density of Cu*(2D5/2) metastable atoms remained below the detection limit of 1 × 1010 cm-3 for magnetron discharge powers below 50 W and hence increased much more rapidly than the density of Cu(2S1/2) atoms, over passing this later at some discharge power, whose value decreases with increasing argon pressure. This behaviour is believed to result from the enhancement of plasma density with increasing discharge power and argon pressure, which would increase the excitation rate of copper into metastable states. At fixed pressure, the deposition rate followed the same trend as the total density of copper atoms in the ground and metastable states. Two important conclusions of this work are (i) copper atoms sputtered from the target under ion bombardment are almost all in the ground state Cu(2S1/2) and hence in the plasma volume they can be excited into the metastable states; (ii) all atoms in the long-lived ground and metastable states contribute to the deposition of copper layer on the substrate.

EFFECTS OF LASER RADIATION ON MATTER. LASER PLASMA: Steepening of the density profile under the action of a ponderomotive force during isothermal planar plasma expansion

NASA Astrophysics Data System (ADS)

Garanin, Sergey G.; Kir'yanov, Yu F.; Kochemasov, G. G.

1990-06-01

A theoretical investigation is reported of the deformation of the density profile of a plasma by a ponderomotive force under transient conditions. Initially, the structure of the density profile near the critical point coincides exactly with the solution of the steady-state problem. Plasma expansion is accompanied by growth of a spiky instability in the form of stimulated Brillouin scattering.

Sensitivity of condition indices to changing density in a white-tailed deer population

USGS Publications Warehouse

Sams, M.G.; Lochmiller, R.L.; Qualls, C.W.; Leslie, David M.

1998-01-01

The ways in which comprehensive condition profiles, incorporating morphometric, histologic, physiologic, and diet quality indices, responded to changes in density of a white-tailed deer (Odocoileus virginianus) population were examined. Changes in these condition indices were monitored in a northeastern Oklahoma deer herd as density declined from peaks of 80 and 72 deer/km2 in 1989 and 1990 (high-density) to lows of 39 and 41 deer/km2 in 1991 and 1992 (reduced-density), respectively. Compared to a reference population (6 deer/km2), deer sampled during high-density exhibited classic signs of nutritional stress such as low body and visceral organ masses (except elevated adrenal gland mass), low fecal nitrogen levels, reduced concentrations of serum albumin, elevated serum creatinine concentrations, and a high prevalence of parasitic infections. Although density declined by one half over the 4-yr study, gross indices of condition (in particular body mass and size) remained largely unchanged. However, selected organ masses, serum albumin and non-protein nitrogen constituents, and fecal nitrogen indices reflected improvements in nutritional status with reductions in density. Many commonly used indices of deer condition (fat reserves, hematocrit, total serum protein, and blood urea nitrogen) were not responsive to fluctuations in density. ?? Wildlife Disease Association 1998.

Impact of Te and ne on edge current density profiles in ELM mitigated regimes on ASDEX Upgrade

NASA Astrophysics Data System (ADS)

Dunne, M. G.; Rathgeber, S.; Burckhart, A.; Fischer, R.; Giannone, L.; McCarthy, P. J.; Schneider, P. A.; Wolfrum, E.; the ASDEX Upgrade Team

2015-01-01

ELM resolved edge current density profiles are reconstructed using the CLISTE equilibrium code. As input, highly spatially and temporally resolved edge electron temperature and density profiles are used in addition to data from the extensive set of external poloidal field measurements available at ASDEX Upgrade, flux loop difference measurements, and current measurements in the scrape-off layer. Both the local and flux surface averaged current density profiles are analysed for several ELM mitigation regimes. The focus throughout is on the impact of altered temperature and density profiles on the current density. In particular, many ELM mitigation regimes rely on operation at high density. Two reference plasmas with type-I ELMs are analysed, one with a deuterium gas puff and one without, in order to provide a reference for the behaviour in type-II ELMy regimes and high density ELM mitigation with external magnetic perturbations at ASDEX Upgrade. For type-II ELMs it is found that while a similar pedestal top pressure is sustained at the higher density, the temperature gradient decreases in the pedestal. This results in lower local and flux surface averaged current densities in these phases, which reduces the drive for the peeling mode. No significant differences between the current density measured in the type-I phase and ELM mitigated phase is seen when external perturbations are applied, though the pedestal top density was increased. Finally, ELMs during the nitrogen seeded phase of a high performance discharge are analysed and compared to ELMs in the reference phase. An increased pedestal pressure gradient, which is the source of confinement improvement in impurity seeded discharges, causes a local current density increase. However, the increased Zeff in the pedestal acts to reduce the flux surface averaged current density. This dichotomy, which is not observed in other mitigation regimes, could act to stabilize both the ballooning mode and the peeling mode at the same time.

Observational and Numerical Diagnostics of Galaxy Cluster Outer Regions

NASA Technical Reports Server (NTRS)

Eckert, D.; Vazza, F.; Ettori, S.; Molendi, S.; Nagai, D.; Lau, E.; Roncarelli, M.; Rossetti, M.; Snowden, S. L.; Gastaldello, F.

2011-01-01

Aims. We present the analysis of a local (z = 0.04 - 0.2) sample of 31 galaxy clusters with the aim of measuring the density of the X-ray emitting gas in cluster outskirts. We compare our results with numerical simulations to set constraints on the azimuthal symmetry and gas clumping in the outer regions of galaxy clusters. Methods. We exploit the large field-of-view and low instrumental background of ROSAT/PSPC to trace the density of the intracluster gas out to the virial radius. We perform a stacking of the density profiles to detect a signal beyond r(sub 200) and measure the typical density and scatter in cluster outskirts. We also compute the azimuthal scatter of the profiles with respect to the mean value to look for deviations from spherical symmetry. Finally, we compare our average density and scatter profiles with the results of numerical simulations. Results. As opposed to several recent results, we observe a steepening of the density profiles beyond approximately 0.3r(sub 500). Comparing our density profiles with simulations, we find that non-radiative runs predict too steep density profiles, whereas runs including additional physics and/or gas clumping are in better agreement with the observed gas distribution. We note a systematic difference between cool-core and non-cool core clusters beyond approximately 0.3r(sub 200), which we explain by a different distribution of the gas in the two classes. Beyond approximately r(sub 500), galaxy clusters deviate significantly from spherical symmetry, with only little differences between relaxed and disturbed systems. We find good agreement between the observed and predicted scatter profiles, but only when the 1% densest clumps are filtered out in the simulations. Conclusions. The general trend of steepening density around the virial radius indicates that the shallow density profiles found in several recent works were probably obtained along particular directions (e.g., filaments) and are not representative of the typical behavior of clusters. Comparing our results with numerical simulations, we find that non-radiative simulations fail to reproduce the gas distribution, even well outside cluster cores. Therefore, a detailed treatment of gas cooling, star formation, clumping, and AGN feedback is required to construct realistic models of cluster outer regions.

Measurement of density and temperature in a hypersonic turbulent boundary layer using the electron beam fluorescence technique. Ph.D. Thesis. Final Report, 1 Oct. 1969 - 1 Sep. 1972

NASA Technical Reports Server (NTRS)

Mcronald, A. D.

1975-01-01

Mean density and temperature fluctuations were measured across the turbulent, cooled-wall boundary layer in a continuous hypersonic (Mach 9.4) wind tunnel in air, using the nitrogen fluorescence excited by a 50 kV electron beam. Data were taken at three values of the tunnel stagnation pressure, the corresponding free stream densities being equivalent to 1.2, 4.0, and 7.4 torr at room temperature, and the boundary layer thicknesses about 4.0, 4.5, and 6.0 inches. The mean temperature and density profiles were similar to those previously determined in the same facility by conventional probes (static and pitot pressure, total temperature). A static pressure variation of about 50% across the boundary layer was found, the shape of the variation changing somewhat for the three stagnation pressure levels. The quadrupole model for rotational temperature spectra gave closer agreement with the free stream isentropic level (approximately 44 K) than the dipole model.

Performance Assessment of Kernel Density Clustering for Gene Expression Profile Data

PubMed Central

Zeng, Beiyan; Chen, Yiping P.; Smith, Oscar H.

2003-01-01

Kernel density smoothing techniques have been used in classification or supervised learning of gene expression profile (GEP) data, but their applications to clustering or unsupervised learning of those data have not been explored and assessed. Here we report a kernel density clustering method for analysing GEP data and compare its performance with the three most widely-used clustering methods: hierarchical clustering, K-means clustering, and multivariate mixture model-based clustering. Using several methods to measure agreement, between-cluster isolation, and withincluster coherence, such as the Adjusted Rand Index, the Pseudo F test, the r2 test, and the profile plot, we have assessed the effectiveness of kernel density clustering for recovering clusters, and its robustness against noise on clustering both simulated and real GEP data. Our results show that the kernel density clustering method has excellent performance in recovering clusters from simulated data and in grouping large real expression profile data sets into compact and well-isolated clusters, and that it is the most robust clustering method for analysing noisy expression profile data compared to the other three methods assessed. PMID:18629292

Analysis of Rotation and Transport Data in C-Mod ITB Plasmas

NASA Astrophysics Data System (ADS)

Fiore, C. L.; Rice, J. E.; Reinke, M. L.; Podpaly, Y.; Bespamyatnov, I. O.; Rowan, W. L.

2009-11-01

Internal transport barriers (ITBs) spontaneously form near the half radius of Alcator C-Mod plasmas when the EDA H-mode is sustained for several energy confinement times in either off-axis ICRF heated discharges or in purely ohmic heated plasmas. These plasmas exhibit strongly peaked density and pressure profiles, static or peaking temperature profiles, peaking impurity density profiles, and thermal transport coefficients that approach neoclassical values in the core. It has long been observed that the intrinsic central plasma rotation that is strongly co-current following the H-mode transition slows and often reverses as the density peaks as the ITB forms. Recent spatial measurements demonstrate that the rotation profile develops a well in the core region that decreases continuously as central density rises while the value outside of the core remains strongly co-current. This results in the formation of a steep potential gradient/strong electric field at the location of the foot of the ITB density profile. The resulting E X B shearing rate is also quite significant at the foot. These analyses and the implications for plasma transport and stability will be presented.

Tempol improves lipid profile and prevents left ventricular hypertrophy in LDL receptor gene knockout (LDLr-/-) mice on a high-fat diet.

PubMed

Viana Gonçalves, Igor Cândido; Cerdeira, Cláudio Daniel; Poletti Camara, Eduardo; Dias Garcia, José Antônio; Ribeiro Pereira Lima Brigagão, Maísa; Bessa Veloso Silva, Roberta; Bitencourt Dos Santos, Gérsika

2017-09-01

Dyslipidemia is associated with increased risk of cardiovascular disease and atherosclerosis, and hence with high morbidity and mortality. This study investigated the effects of the nitroxide 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (Tempol) on lipid profile and cardiac morphology in low-density lipoprotein (LDL) receptor gene knockout (LDLr-/-) mice. Male LDLr-/- mice (three months old, approximately 22 g weight) were divided into the following groups: controls, including (1) standard chow (SC, n=8) and (2) high-fat diet (HFD, n=8); and treatment, including (3) standard chow + Tempol (SC+T, n=8) (30 mg/kg administered by gavage, once daily) and (4) high-fat diet + Tempol (HFD+T, n=8) (30 mg/kg). After 30 days of the diet/treatment, whole blood was collected for analysis of biochemical parameters (total cholesterol, triglycerides [TG], high-density lipoprotein [HDL], LDL, and very low-density lipoprotein [VLDL]). The heart was removed through thoracotomy and histological analysis of the left ventricle was performed. A significant increase in TG, LDL, and VLDL and marked left ventricular hypertrophy (LVH) were demonstrated in the HFD group relative to the SC group (p<0.05), while Tempol treatment (HFD+T group) significantly (p<0.05) prevented increases in the levels of these lipid profile markers and attenuated LVH compared with the HFD group. In this study, Tempol showed potential for the prevention of events related to serious diseases of the cardiovascular system. Copyright © 2017 Sociedade Portuguesa de Cardiologia. Publicado por Elsevier España, S.L.U. All rights reserved.

Lipoprotein metabolism in Japanese centenarians: effects of apolipoprotein E polymorphism and nutritional status.

PubMed

Arai, Y; Hirose, N; Nakazawa, S; Yamamura, K; Shimizu, K; Takayama, M; Ebihara, Y; Osono, Y; Homma, S

2001-11-01

To assess the complex interaction of apolipoprotein (apo) E polymorphisms and environmental factors on lipoprotein profile in centenarians. Cross-sectional analysis. Tokyo metropolitan area. Seventy-five centenarians and 73 healthy older volunteers (mean age 63.1 +/- 10.0) living in the Tokyo metropolitan area. Plasma lipids and lipoproteins, cholesteryl ester transfer protein mass, apo E phenotype, body mass index, nutritional indices (serum albumin, prealbumin, transferrin), dietary intake, inflammation markers (C-reactive protein (CRP), interleukin-6 (IL-6)), activities of daily living, and cognitive function. In comparison with older people, the centenarians had low concentrations of total and low-density lipoprotein cholesterol (LDL-C) and a relative predominance of high-density lipoprotein 2 cholesterol. No environmental factor, except the number of apo E epsilon2 alleles, was a significant determinant of LDL-C and apo B, suggesting that the low apo B-containing lipoprotein in centenarians may be attributable to a genetic cause. Centenarians had elevated levels of lipoprotein (a) and decreased high-density lipoprotein cholesterol (HDL-C), which seem to be an unfavorable lipoprotein profile. Lower levels of HDL-C in the centenarians were associated with decreased serum albumin, elevated CRP and IL-6 levels, and cognitive impairment, suggesting that HDL-C could be a sensitive marker for frailty and comorbidity in the oldest old. Low levels of apo B-containing lipoproteins attributable to a genetic cause may be advantageous for longevity. Lipoprotein profiles in centenarians were consistently related to the subjects' nutritional status, inflammation markers, and apo E polymorphisms. The results provide evidence for the importance of maintaining nutritional status in the very old.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chae, Kyu-Hyun; Kravtsov, Andrey V.; Frieman, Joshua A.

With SDSS galaxy data and halo data from up-to-date N-body simulations we construct a semi-empirical catalog (SEC) of early-type systems by making a self-consistent bivariate statistical match of stellar mass (M_star) and velocity dispersion (sigma) with halo virial mass (M_vir). We then assign stellar mass profile and velocity dispersion profile parameters to each system in the SEC using their observed correlations with M_star and sigma. Simultaneously, we solve for dark matter density profile of each halo using the spherical Jeans equation. The resulting dark matter density profiles deviate in general from the dissipationless profile of NFW or Einasto and theirmore » mean inner density slope and concentration vary systematically with M_vir. Statistical tests of the distribution of profiles at fixed M_vir rule out the null hypothesis that it follows the distribution predicted by N-body simulations for M_vir ~< 10^{13.5-14.5} M_solar. These dark matter profiles imply that dark matter density is, on average, enhanced significantly in the inner region of halos with M_vir ~< 10^{13.5-14.5} M_solar supporting halo contraction. The main characteristics of halo contraction are: (1) the mean dark matter density within the effective radius has increased by a factor varying systematically up to ~ 3-4 at M_vir = 10^{12} M_solar, and (2) the inner density slope has a mean of ~ 1.3 with rho(r) ~ r^{-alpha} and a halo-to-halo rms scatter of rms(alpha) ~ 0.4-0.5 for 10^{12} M_solar ~< M_vir ~< 10^{13-14} M_solar steeper than the NFW profile (alpha=1). Based on our results we predict that halos of nearby elliptical and lenticular galaxies can, in principle, be promising targets for gamma-ray emission from dark matter annihilation.« less

Correlations and sum rules in a half-space for a quantum two-dimensional one-component plasma

NASA Astrophysics Data System (ADS)

Jancovici, B.; Šamaj, L.

2007-05-01

This paper is the continuation of a previous one (Šamaj and Jancovici, 2007 J. Stat. Mech. P02002); for a nearly classical quantum fluid in a half-space bounded by a plain plane hard wall (no image forces), we had generalized the Wigner Kirkwood expansion of the equilibrium statistical quantities in powers of Planck's constant \\hbar . As a model system for a more detailed study, we consider the quantum two-dimensional one-component plasma: a system of charged particles of one species, interacting through the logarithmic Coulomb potential in two dimensions, in a uniformly charged background of opposite sign, such that the total charge vanishes. The corresponding classical system is exactly solvable in a variety of geometries, including the present one of a half-plane, when βe2 = 2, where β is the inverse temperature and e is the charge of a particle: all the classical n-body densities are known. In the present paper, we have calculated the expansions of the quantum density profile and truncated two-body density up to order \\hbar ^2 (instead of only to order \\hbar as in the previous paper). These expansions involve the classical n-body densities up to n = 4; thus we obtain exact expressions for these quantum expansions in this special case. For the quantum one-component plasma, two sum rules involving the truncated two-body density (and, for one of them, the density profile) have been derived, a long time ago, by using heuristic macroscopic arguments: one sum rule concerns the asymptotic form along the wall of the truncated two-body density; the other one concerns the dipole moment of the structure factor. In the two-dimensional case at βe2 = 2, we now have explicit expressions up to order \\hbar^2 for these two quantum densities; thus we can microscopically check the sum rules at this order. The checks are positive, reinforcing the idea that the sum rules are correct.

Semi-empirical catalog of early-type galaxy-halo systems: dark matter density profiles, halo contraction and dark matter annihilation strength

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chae, Kyu-Hyun; Kravtsov, Andrey V.; Frieman, Joshua A.

With Sloan Digital Sky Survey galaxy data and halo data from up-to-date N-body simulations within the ΛCDM framework we construct a semi-empirical catalog (SEC) of early-type galaxy-halo systems by making a self-consistent bivariate statistical match of stellar mass (M{sub *}) and velocity dispersion (σ) with halo virial mass (M{sub vir}) as demonstrated here for the first time. We then assign stellar mass profile and velocity dispersion profile parameters to each system in the SEC using their observed correlations with M{sub *} and σ. Simultaneously, we solve for dark matter density profile of each halo using the spherical Jeans equation. Themore » resulting dark matter density profiles deviate in general from the dissipationless profile of Navarro-Frenk-White or Einasto and their mean inner density slope and concentration vary systematically with M{sub vir}. Statistical tests of the distribution of profiles at fixed M{sub vir} rule out the null hypothesis that it follows the distribution predicted by dissipationless N-body simulations for M{sub vir}∼<10{sup 13.5} {sup –} {sup 14.5} M{sub s}un. These dark matter profiles imply that dark matter density is, on average, enhanced significantly in the inner region of halos with M{sub vir}∼<10{sup 13.5} {sup –} {sup 14.5} M{sub s}un supporting halo contraction. The main characteristics of halo contraction are: (1) the mean dark matter density within the effective radius has increased by a factor varying systematically up to ≈ 3–4 at M{sub vir} = 10{sup 12} M{sub s}un, and (2) the inner density slope has a mean of (α) ≈ 1.3 with ρ{sub dm}(r)∝r{sup −α} and a halo-to-halo rms scatter of rms(α) ∼ 0.4–0.5 for 10{sup 12} M{sub s}un∼« less

Impurity profiles and radial transport in the EXTRAP-T2 reversed field pinch

NASA Astrophysics Data System (ADS)

Sallander, J.

1999-05-01

Radially resolved spectroscopy has been used to measure the radial distribution of impurity ions (O III-O V and C III-CVI) in the EXTRAP-T2 reversed field pinch (RFP). The radial profile of the emission is reconstructed from line emission measured along five lines of sight. The ion density profile is the fitted quantity in the reconstruction of the brightness profile and is thus obtained directly in this process. These measurements are then used to adjust the parameters in transport calculations in order to obtain consistency with the observed ion density profiles. Comparison between model and measurements show that a radial dependence in the diffusion is needed to explain the measured ion densities.

Using Ice and Dust Lines to Constrain the Surface Densities of Protoplanetary Disks

NASA Astrophysics Data System (ADS)

Powell, Diana; Murray-Clay, Ruth; Schlichting, Hilke

2018-04-01

The surface density of protoplanetary disks is a fundamental parameter that still remains largely unconstrained due to uncertainties in the dust-to-gas ratio and CO abundance. In this talk I will present a novel method for determining the surface density of protoplanetary disks through consideration of disk “dust lines,” which indicate the observed disk radial scale at different observational wavelengths. I will provide an initial proof of concept of our model through an application to the disk TW Hya where we are able to estimate the disk dust-to-gas ratio, CO abundance, and accretion rate in addition to the total disk surface density. We find that our derived surface density profile and dust-to-gas ratio are consistent with the lower limits found through measurements of HD gas. We further apply our model to a large parameter space of theoretical disks and find three observational diagnostics that may be used to test its validity. Using this method we derive disks that may be much more massive than previously thought, often approaching the limit of gravitational stability.

Temporal Behavior of the Ionospheric Electron Density at Low Latitudes: First Glimpse

NASA Astrophysics Data System (ADS)

Gjerloev, J. W.; Humberset, B. K.; Gonzalez, S. A.; Garnett Marques Brum, C.

2013-12-01

In this paper we address the spatiotemporal characteristics of the electron density at 150 km altitude in the low latitude ionosphere above the Arecibo Observatory. We utilize a new pointing mode that allows us to probe the same volume in the ionosphere for a continuous period of approximately 25 min. or more. The ISR profiles have 150 m range resolution and samples have a 10-second time resolution; we probed 60 individual regions uniformly spaced in local times and covering the full 24 hours. For each time series we determine the total derivative of the electron density using a narrow Hanning bandpass filter that allow us to determine the variability at different frequencies. This is done for each of the 60 local time regions. We further compare to widely used static statistical models and test their underlying assumption: Dynamics can be ignored.

Vegan diet and blood lipid profiles: a cross-sectional study of pre and postmenopausal women

PubMed Central

2014-01-01

Background Vegan diet has been associated with lower risk of cardiovascular diseases and mortality, partly due to its effects on serum lipid profiles. Lipid profiles [high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C) and triglycerides (TG)] have not been fully elucidated either in pre and postmenopausal vegans or in ovo-lacto vegetarians. This study aimed to compare lipid profiles among vegans, ovo-lacto vegetarians and omnivores. Methods Demographic data and lipid profiles were obtained from the 2002 Taiwanese Survey on Hypertension, Hyperglycemia and Hyperlipidemia. Multivariate linear regression analysis was used to examine factors significantly and independently associated with different categories of veganism and to estimate the β value of lipid profiles in the dietary types. Results A total of 2397 premenopausal and 1154 postmenopausal participants who did not receive lipid lowering drugs were enrolled. Premenopausal vegans had significantly lower HDL-C and higher TG, LDL-C/HDL-C, total cholesterol (TC)/HDL-C and TG/HDL-C compared with omnivores. For postmenopausal women, vegans had lower TC while ovo-lacto vegetarians were observed with low HDL-C when compared with omnivores. Multivariate linear regression analyses showed that vegan and ovo-lacto vegetarian diets decreased HDL-C levels in premenopausal women (β = -7.63, p = 0.001 and β = -4.87, p = 0.001, respectively). There were significant associations between lower LDL-C and ovo-lacto vegetarian diets (β = -7.14, p = 0.008) and also between TG and vegan diet (β = 23.37, p = 0.008), compared with omnivorous diet. Post-menopausal women reported to have consumed either a vegan or an ovo-lacto vegetarian diet were at the risk of having low HDL-C unlike those that consumed omnivorous diets (β = -4.88, p = 0.015 and β = -4.48, p = 0.047). There were no significant changes in LDL-C in both pre and postmenopausal vegans. Conclusions Vegan diet was associated with reduced HDL-C level. Because of its effects on lowering HDL-C and LDL-C, ovo-lacto vegetarian diet may be more appropriate for premenopausal women. PMID:24712525

Effect of flaxseed gum on reduction of blood glucose and cholesterol in type 2 diabetic patients.

PubMed

Thakur, Goutam; Mitra, Analava; Pal, Kunal; Rousseau, Dérick

2009-01-01

The effects of ingestion of flaxseed gum on blood glucose and cholesterol, particularly low-density lipoprotein cholesterol, in type 2 diabetes were evaluated. Flaxseed gum was incorporated in wheat flour chapattis. Sixty patients of type 2 diabetes were fed a daily diet for 3 months, along with six wheat flour chapattis containing flaxseed gum (5 g), as per the recommendations of the American Diabetic Association. The control group (60 individuals) consumed an identical diet but the chapattis were without gum. The blood biochemistry profiles monitored before starting the study and at monthly intervals showed fasting blood sugar in the experimental group decreased from 154 ± 8 mg/dl to 136 ± 7 mg/dl (P=0.03) while the total cholesterol reduced from 182 ± 11 mg/dl to 163 ± 9 mg/dl (P=0.03). Results showed a decrease in low-density lipoprotein cholesterol from 110 ± 8 mg/dl to 92 ± 9 mg/dl (P=0.02). The study demonstrated the efficacy of flax gum in the blood biochemistry profiles of type 2 diabetes.

Investigation of low-latitude hydrogen emission in terms of a two-component interstellar gas model

NASA Technical Reports Server (NTRS)

Baker, P. L.; Burton, W. B.

1975-01-01

High-resolution 21-cm hydrogen line observations at low galactic latitude are analyzed to determine the large-scale distribution of galactic hydrogen. Distribution parameters are found by model fitting, optical depth effects are computed using a two-component gas model suggested by the observations, and calculations are made for a one-component uniform spin-temperature gas model to show the systematic departures between this model and data obtained by incorrect treatment of the optical depth effects. Synthetic 21-cm line profiles are computed from the two-component model, and the large-scale trends of the observed emission profiles are reproduced together with the magnitude of the small-scale emission irregularities. Values are determined for the thickness of the galactic hydrogen disk between half density points, the total observed neutral hydrogen mass of the galaxy, and the central number density of the intercloud hydrogen atoms. It is shown that typical hydrogen clouds must be between 1 and 13 pc in diameter and that optical thinness exists on large-scale despite the presence of optically thin gas.

Local ionospheric electron density reconstruction from simultaneous ground-based GNSS and ionosonde measurements

NASA Astrophysics Data System (ADS)

Stankov, S. M.; Warnant, R.; Stegen, K.

2009-04-01

The purpose of the LIEDR (Local Ionospheric Electron Density Reconstruction) system is to acquire and process data from simultaneous ground-based GNSS TEC and digital ionosonde measurements, and subsequently to deduce the vertical electron density distribution in the local ionosphere. LIEDR is primarily designed to operate in real time for service applications, and, if sufficient data from solar and geomagnetic observations are available, to provide short-term forecast as well. For research applications and further development of the system, a post-processing mode of operation is also envisaged. In essence, the reconstruction procedure consists in the following. The high-precision ionosonde measurements are used for directly obtaining the bottom part of the electron density profile. The ionospheric profiler for the lower side (i.e. below the density peak height, hmF2) is based on the Epstein layer functions using the known values of the critical frequencies, foF2 and foE, and the propagation factor, M3000F2. The corresponding bottom-side part of the total electron content is calculated from this profile and is then subtracted from the GPS TEC value in order to obtain the unknown portion of the TEC in the upper side (i.e. above the hmF2). Ionosonde data, together with the simultaneously-measured TEC and empirically obtained O+/H+ ion transition level values, are all required for the determination of the topside electron density scale height. The topside electron density is considered as a sum of the constituent oxygen and hydrogen ion densities with unknown vertical scale heights. The latter are calculated by solving a system of transcendental equations that arise from the incorporation of a suitable ionospheric profiler (Chapman, Epstein, or Exponential) into formulae describing ionospheric conditions (plasma quasi-neutrality, ion transition level). Once the topside scale heights are determined, the construction of the vertical electron density distribution in the entire altitude range is a straightforward process. As a by-product of the described procedure, the value of the ionospheric slab thickness can be easily computed. To be able to provide forecast, additional information about the current solar and geomagnetic activity is needed. For the purpose, observations available in real time -- at the Royal Institute of Meteorology (RMI), the Royal Observatory of Belgium (ROB), and the US National Oceanic and Atmospheric Administration (NOAA) -- are used. Recently, a new hybrid model for estimating and predicting the local magnetic index K has been developed. This hybrid model has the advantage of using both, ground-based (geomagnetic field components) and space-based (solar wind parameters) measurements, which results in more reliable estimates of the level of geomagnetic activity - current and future. The described reconstruction procedure has been tested on actual measurements at the RMI Dourbes Geophysics Centre (coordinates: 50.1N, 4.6E) where a GPS receiver is collocated with a digital ionosonde (code: DB049, type: Lowell DGS 256). Currently, the nominal time resolution between two consecutive reconstructions is set to 15 minutes with a forecast horizon for each reconstruction of up to 60 minutes. Several applications are envisaged. For example, the ionospheric propagation delays can be estimated and corrected much easier if the electron density profile is available at a nearby location on a real-time basis. Also, both the input data and the reconstruction results can be used for validation purposes in ionospheric models, maps, and services. Recent studies suggest that such ionospheric monitoring systems can help research/services related to aircraft navigation, e.g. for development of the ‘ionospheric threat' methodology.

Comparison of hybrid and baseline ELMy H-mode confinement in JET with the carbon wall

NASA Astrophysics Data System (ADS)

Beurskens, M. N. A.; Frassinetti, L.; Challis, C.; Osborne, T.; Snyder, P. B.; Alper, B.; Angioni, C.; Bourdelle, C.; Buratti, P.; Crisanti, F.; Giovannozzi, E.; Giroud, C.; Groebner, R.; Hobirk, J.; Jenkins, I.; Joffrin, E.; Leyland, M. J.; Lomas, P.; Mantica, P.; McDonald, D.; Nunes, I.; Rimini, F.; Saarelma, S.; Voitsekhovitch, I.; de Vries, P.; Zarzoso, D.; Contributors, JET-EFDA

2013-01-01

The confinement in JET baseline type I ELMy H-mode plasmas is compared to that in so-called hybrid H-modes in a database study of 112 plasmas in JET with the carbon fibre composite (CFC) wall. The baseline plasmas typically have βN ˜ 1.5-2, H98 ˜ 1, whereas the hybrid plasmas have βN ˜ 2.5-3, H98 < 1.5. The database study contains both low- (δ ˜ 0.2-0.25) and high-triangularity (δ ˜ 0.4) hybrid and baseline H-mode plasmas from the last JET operational campaigns in the CFC wall from the period 2008-2009. Based on a detailed confinement study of the global as well as the pedestal and core confinement, there is no evidence that the hybrid and baseline plasmas form separate confinement groups; it emerges that the transition between the two scenarios is of a gradual kind rather than demonstrating a bifurcation in the confinement. The elevated confinement enhancement factor H98 in the hybrid plasmas may possibly be explained by the density dependence in the τ98 scaling as n0.41 and the fact that the hybrid plasmas operate at low plasma density compared to the baseline ELMy H-mode plasmas. A separate regression on the confinement data in this study shows a reduction in the density dependence as n0.09±0.08. Furthermore, inclusion of the plasma toroidal rotation in the confinement regression provides a scaling with the toroidal Alfvén Mach number as Mach_A^{0.41+/- 0.07} and again a reduced density dependence as n0.15±0.08. The differences in pedestal confinement can be explained on the basis of linear MHD stability through a coupling of the total and pedestal poloidal pressure and the pedestal performance can be improved through plasma shaping as well as high β operation. This has been confirmed in a comparison with the EPED1 predictive pedestal code which shows a good agreement between the predicted and measured pedestal pressure within 20-30% for a wide range of βN ˜ 1.5-3.5. The core profiles show a strong degree of pressure profile consistency. No beneficial effect of core density peaking on confinement could be identified for the majority of the plasmas presented here as the density peaking is compensated by a temperature de-peaking resulting in no or only a weak variation in the pressure peaking. The core confinement could only be optimized in case the ions and electrons are decoupled, in which case the ion temperature profile peaking can be enhanced, which benefits confinement. In this study, the latter has only been achieved in the low-triangularity hybrid plasmas, and can be attributed to low-density operation. Plasma rotation has been found to reduce core profile stiffness, and can explain an increase in profile peaking at small radius ρtor = 0.3.

An adaptive technique for estimating the atmospheric density profile during the AE mission

NASA Technical Reports Server (NTRS)

Argentiero, P.

1973-01-01

A technique is presented for processing accelerometer data obtained during the AE missions in order to estimate the atmospheric density profile. A minimum variance, adaptive filter is utilized. The trajectory of the probe and probe parameters are in a consider mode where their estimates are unimproved but their associated uncertainties are permitted an impact on filter behavior. Simulations indicate that the technique is effective in estimating a density profile to within a few percentage points.

Effects of ICRF power on SOL density profiles and LH coupling during simultaneous LH and ICRF operation on Alcator C-Mod

NASA Astrophysics Data System (ADS)

Lau, C.; Lin, Y.; Wallace, G.; Wukitch, S. J.; Hanson, G. R.; Labombard, B.; Ochoukov, R.; Shiraiwa, S.; Terry, J.

2013-09-01

A dedicated experiment during simultaneous lower hybrid (LH) and ion cyclotron range-of-frequencies (ICRF) operations is carried out to evaluate and understand the effects of ICRF power on the scrape-off-layer (SOL) density profiles and on the resultant LH coupling for a wide range of plasma parameters on Alcator C-Mod. Operation of the LH launcher with the adjacent ICRF antenna significantly degrades LH coupling while operation with the ICRF antenna that is not magnetically connected to the LH launcher minimally affects LH coupling. An X-mode reflectometer system at three poloidal locations adjacent to the LH launcher and a visible video camera imaging the LH launcher are used to measure local SOL density profile and emissivity modifications with the application of LH and LH + ICRF power. These measurements confirm that the density in front of the LH launcher depends strongly on the magnetic field line mapping of the active ICRF antenna. Reflectometer measurements also observe both ICRF-driven and LH-driven poloidal density profile asymmetries, especially a strong density depletion at certain poloidal locations in front of the LH launcher during operation with a magnetically connected ICRF antenna. The results indicate that understanding both LH-driven flows and ICRF sheath driven flows may be necessary to understand the observed density profile modifications and LH coupling results during simultaneous LH + ICRF operation.

Density profile of dark matter haloes and galaxies in the HORIZON-AGN simulation: the impact of AGN feedback

NASA Astrophysics Data System (ADS)

Peirani, Sébastien; Dubois, Yohan; Volonteri, Marta; Devriendt, Julien; Bundy, Kevin; Silk, Joe; Pichon, Christophe; Kaviraj, Sugata; Gavazzi, Raphaël; Habouzit, Mélanie

2017-12-01

Using a suite of three large cosmological hydrodynamical simulations, HORIZON-AGN, HORIZON–NOAGN (no AGN feedback) and HORIZON-DM (no baryons), we investigate how a typical sub-grid model for AGN feedback affects the evolution of the inner density profiles of massive dark matter haloes and galaxies. Based on direct object-to-object comparisons, we find that the integrated inner mass and density slope differences between objects formed in these three simulations (hereafter, HAGN, HnoAGN and HDM) significantly evolve with time. More specifically, at high redshift (z ∼ 5), the mean central density profiles of HAGN and HnoAGN dark matter haloes tend to be much steeper than their HDM counterparts owing to the rapidly growing baryonic component and ensuing adiabatic contraction. By z ∼ 1.5, these mean halo density profiles in HAGN have flattened, pummelled by powerful AGN activity ('quasar mode'): the integrated inner mass difference gaps with HnoAGN haloes have widened, and those with HDM haloes have narrowed. Fast forward 9.5 billion years, down to z = 0, and the trend reverses: HAGN halo mean density profiles drift back to a more cusped shape as AGN feedback efficiency dwindles ('radio mode'), and the gaps in integrated central mass difference with HnoAGN and HDM close and broaden, respectively. On the galaxy side, the story differs noticeably. Averaged stellar profile central densities and inner slopes are monotonically reduced by AGN activity as a function of cosmic time, resulting in better agreement with local observations.

[Distribution of soil organic carbon storage and carbon density in Gahai Wetland ecosystem].

PubMed

Ma, Wei-Wei; Wang, Hui; Huang, Rong; Li, Jun-Zhen; Li, De-Yu

2014-03-01

The profile distribution and accumulation characteristics of organic carbon of four typical marshes (herbaceous peat, marsh wetland, mountain wetland, subalpine meadow) were studied in Gahai Wetlands of Gannan in July 2011. The results showed that the soil bulk densities of the four typical marshes ranged from 0.22 to 1.29 g x cm(-3). The content of soil organic carbon in the herbaceous peat was higher than in other types, with its average content of organic carbon (286. 80 g x kg(-1)) being about 2.91, 4.99, 7.31 times as much as that of the marsh wetland, mountain wetland and subalpine meadow, respectively. The average organic carbon densities were in order of herbaceous peat > subalpine meadow > marsh wetland > mountain wetland, with the highest in the 0-10 cm layer. The change of organic carbon density along the soil profile was basically in accordance with the organic carbon content in the four typical marshes, but fluctuated with soil depth. There were obviously two carbon storage layers (0-10 and 20-40 cm, respectively) in the four typical marshes. The amounts of organic carbon stored in the 0-60 cm layer of the four typical marshes were 369.46, 278.83, 276.16, 292.23 t x hm(-2), respectively. The total amount of organic carbon stored in the 0-60 cm of the four typical marshes was about 9.50 x 10(6) t.

Halo density profiles and baryon physics

NASA Astrophysics Data System (ADS)

Del Popolo, A.; Li, Xi-Guo

2017-08-01

The radial dependence of the pseudo phase-space density, ρ( r)/ σ 3( r) is studied. We find that the pseudo phase-space density for halos consisting both of dark matter and baryons is approximately a power-law only down to 0.1% of the virial radius while it has a non-power law behavior below the quoted scale, with inner profiles changing with mass. Halos consisting just of dark matter, as the one in dark matter only simulations, are characterized by an approximately power-law behavior. The results argue against universality of the pseudo phase-space density, when the baryons effect are included, and as a consequence argue against universality of density profiles constituted by dark matter and baryons as also discussed in [1].

Exercise Effects for Children With Autism Spectrum Disorder: Metabolic Health, Autistic Traits, and Quality of Life.

PubMed

Toscano, Chrystiane V A; Carvalho, Humberto M; Ferreira, José P

2018-02-01

This study examined the effects of a 48-week exercise-based intervention on the metabolic profile, autism traits, and perceived quality of life in children with autism spectrum disorder (ASD). We randomly allocated 64 children with ASD (aged 6-12 years) to experimental ( n = 46) and control groups ( n = 18) and used multilevel regression modeling to examine responses to receiving or not receiving the intervention. The experimental group showed beneficial effects on metabolic indicators (high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and total cholesterol), autism traits, and parent-perceived quality of life. Our results provide support for exercise and physical activity, including basic coordination and strength exercises, as important therapeutic interventions for children with ASD.

(abstract) A Comparison Between Measurements of the F-layer Critical Frequency and Values Derived from the PRISM Adjustment Algorithm Applied to Total Electron Content Data in the Equatorial Region

NASA Technical Reports Server (NTRS)

Mannucci, A. J.; Anderson, D. N.; Abdu, A. M.

1994-01-01

The Parametrized Real-Time Ionosphere Specification Model (PRISM) is a global ionospheric specification model that can incorporate real-time data to compute accurate electron density profiles. Time series of computed and measured data are compared in this paper. This comparison can be used to suggest methods of optimizing the PRISM adjustment algorithm for TEC data obtained at low altitudes.

Micromagnetic study of equilibrium states in nano hemispheroidal shells

NASA Astrophysics Data System (ADS)

Schultz, Keren; Schultz, Moty

2017-11-01

We present results of micromagnetic simulations of thin ferromagnetic nano hemispheroidal shells with sizes ranging from 5 to 50 nm (inside dimensions). Depending on the geometrical and magnetic parameters of the hemispheroidal shell, there exist three different magnetic phases: easy axis, onion and vortex. The profile for the vortex magnetization distribution is analyzed and the limitations and applicability of different vortex ansatzes are discussed. In addition, we investigate the total energy density for each of the magnetic distributions as a function of the hemispheroidal shell dimensions.

Ground state of a confined Yukawa plasma including correlation effects

NASA Astrophysics Data System (ADS)

Henning, C.; Ludwig, P.; Filinov, A.; Piel, A.; Bonitz, M.

2007-09-01

The ground state of an externally confined one-component Yukawa plasma is derived analytically using the local density approximation (LDA). In particular, the radial density profile is computed. The results are compared with the recently obtained mean-field (MF) density profile [Henning , Phys. Rev. E 74, 056403 (2006)]. While the MF results are more accurate for weak screening, the LDA with correlations included yields the proper description for large screening. By comparison with first-principles simulations for three-dimensional spherical Yukawa crystals, we demonstrate that the two approximations complement each other. Together they accurately describe the density profile in the full range of screening parameters.

Kefir consumption does not alter plasma lipid levels or cholesterol fractional synthesis rates relative to milk in hyperlipidemic men: a randomized controlled trial [ISRCTN10820810

PubMed Central

St-Onge, Marie-Pierre; Farnworth, Edward R; Savard, Tony; Chabot, Denise; Mafu, Akier; Jones, Peter JH

2002-01-01

Background Fermented milk products have been shown to affect serum cholesterol concentrations in humans. Kefir, a fermented milk product, has been traditionally consumed for its potential health benefits but has to date not been studied for its hypocholesterolemic properties. Methods Thirteen healthy mildly hypercholesterolemic male subjects consumed a dairy supplement in randomized crossover trial for 2 periods of 4 wk each. Subjects were blinded to the dairy supplement consumed. Blood samples were collected at baseline and after 4 wk of supplementation for measurement of plasma total, low-density lipoprotein, and high-density lipoprotein cholesterol and triglyceride concentrations, as well as fatty acid profile and cholesterol synthesis rate. Fecal samples were collected at baseline and after 2 and 4 wk of supplementation for determination of fecal short chain fatty acid level and bacterial content. Results Kefir had no effect on total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglyceride concentrations nor on cholesterol fractional synthesis rates after 4 wk of supplementation. No significant change on plasma fatty acid levels was observed with diet. However, both kefir and milk increased (p < 0.05) fecal isobutyric, isovaleric and propionic acids as well as the total amount of fecal short chain fatty acids. Kefir supplementation resulted in increased fecal bacterial content in the majority of the subjects. Conclusions Since kefir consumption did not result in lowered plasma lipid concentrations, the results of this study do not support consumption of kefir as a cholesterol-lowering agent. PMID:11825344

Are ultracompact minihalos really ultracompact?

NASA Astrophysics Data System (ADS)

Delos, M. Sten; Erickcek, Adrienne L.; Bailey, Avery P.; Alvarez, Marcelo A.

2018-02-01

Ultracompact minihalos (UCMHs) have emerged as a valuable probe of the primordial power spectrum of density fluctuations at small scales. UCMHs are expected to form at early times in regions with δ ρ /ρ ≳10-3 , and they are theorized to possess an extremely compact ρ ∝r-9 /4 radial density profile, which enhances their observable signatures. Nonobservation of UCMHs can thus constrain the primordial power spectrum. Using N -body simulations to study the collapse of extreme density peaks at z ≃1000 , we show that UCMHs forming under realistic conditions do not develop the ρ ∝r-9 /4 profile and instead develop either ρ ∝r-3 /2 or ρ ∝r-1 inner density profiles depending on the shape of the power spectrum. We also demonstrate via idealized simulations that self-similarity—the absence of a scale length—is necessary to produce a halo with the ρ ∝r-9 /4 profile, and we argue that this implies such halos cannot form from a Gaussian primordial density field. Prior constraints derived from UCMH nonobservation must be reworked in light of this discovery. Although the shallower density profile reduces UCMH visibility, our findings reduce their signal by as little as O (10-2) while allowing later-forming halos to be considered, which suggests that new constraints could be significantly stronger.

Ponderomotive force on solitary structures created during radiation pressure acceleration of thin foils

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tripathi, Vipin K.; Sharma, Anamika

2013-05-15

We estimate the ponderomotive force on an expanded inhomogeneous electron density profile, created in the later phase of laser irradiated diamond like ultrathin foil. When ions are uniformly distributed along the plasma slab and electron density obeys the Poisson's equation with space charge potential equal to negative of ponderomotive potential, φ=−φ{sub p}=−(mc{sup 2}/e)(γ−1), where γ=(1+|a|{sup 2}){sup 1/2}, and |a| is the normalized local laser amplitude inside the slab; the net ponderomotive force on the slab per unit area is demonstrated analytically to be equal to radiation pressure force for both overdense and underdense plasmas. In case electron density is takenmore » to be frozen as a Gaussian profile with peak density close to relativistic critical density, the ponderomotive force has non-monotonic spatial variation and sums up on all electrons per unit area to equal radiation pressure force at all laser intensities. The same result is obtained for the case of Gaussian ion density profile and self consistent electron density profile, obeying Poisson's equation with φ=−φ{sub p}.« less

Electron densities in the ionosphere of Mars: A comparison of MARSIS and radio occultation measurements

NASA Astrophysics Data System (ADS)

Vogt, Marissa F.; Withers, Paul; Fallows, Kathryn; Flynn, Casey L.; Andrews, David J.; Duru, Firdevs; Morgan, David D.

2016-10-01

Radio occultation electron densities measurements from the Mariner 9 and Viking spacecraft, which orbited Mars in the 1970s, have recently become available in a digital format. These data are highly complementary to the radio occultation electron density profiles from Mars Global Surveyor, which were restricted in solar zenith angle and altitude. We have compiled data from the Mariner 9, Viking, and Mars Global Surveyor radio occultation experiments for comparison to electron density measurements made by Mars Advanced Radar for Subsurface and Ionosphere Sounding (MARSIS), the topside radar sounder on Mars Express, and MARSIS-based empirical density models. We find that the electron densities measured by radio occultation are in generally good agreement with the MARSIS data and model, especially near the altitude of the peak electron density but that the MARSIS data and model display a larger plasma scale height than the radio occultation profiles at altitudes between the peak density and 200 km. Consequently, the MARSIS-measured and model electron densities are consistently larger than radio occultation densities at altitudes 200-300 km. Finally, we have analyzed transitions in the topside ionosphere, at the boundary between the photochemically controlled and transport-controlled regions, and identified the average transition altitude, or altitude at which a change in scale height occurs. The average transition altitude is 200 km in the Mariner 9 and Viking radio occultation profiles and in profiles of the median MARSIS radar sounding electron densities.

Vertical and Lateral Electron Content in the Martian Ionosphere

NASA Astrophysics Data System (ADS)

Paetzold, M. P.; Peter, K.; Bird, M. K.; Häusler, B.; Tellmann, S.

2016-12-01

The radio-science experiment MaRS (Mars Express Radio Science) on the Mars Express spacecraft sounds the neutral atmosphere and ionosphere of Mars since 2004. Approximately 800 vertical profiles of the ionospheric electron density have been acquired until today. The vertical electron content (TEC) is easily computed from the vertical electron density profile by integrating along the altitude. The TEC is typically a fraction of a TEC unit (1E16 m^-2) and depends on the solar zenith angle. The magnitude of the TEC is however fully dominated by the electron density contained in the main layer M2. The contributions by the M1 layer below M2 or the topside is marginal. MaRS is using two radio frequencies for the sounding of the ionosphere. The directly observed differential Doppler from the two received frequencies is a measure of the lateral electron content that means along the ray path and perpendicular to the vertical electron density profile. Combining both the vertical electron density profile, the vertical TEC and the directly observed lateral TEC describes the lateral electron density distribution in the ionosphere.

Metabolic Profile in Patients with Mild Obstructive Sleep Apnea.

PubMed

Silva, Luciana Oliveira E; Guimarães, Thais M; Luz, Gabriela P; Coelho, Glaury; Badke, Luciana; Almeida, Ildonete R; Millani-Carneiro, Aline; Tufik, Sergio; Bittencourt, Lia; Togeiro, Sonia M

2018-02-01

Mild obstructive sleep apnea (OSA) is a highly prevalent disorder in adults. However, it is not clear whether mild OSA has significant metabolic complications. This study examined the prevalence of metabolic syndrome (MS) in patients with mild OSA compared to control group. Adults (18-65 years of age) of both genders with a body mass index (BMI) ≤35 kg/m 2 were included. The mild OSA group comprised of patients with an apnea-hypopnea index (AHI) score of ≥5 but ≤15 events/hr of sleep, independent of other symptoms. The control group (CG) comprised individuals with an AHI of <5 events/hr of sleep and an Epworth Sleepiness Scale score of <10. The following were used for both groups: two questionnaires on sleepiness, the maintenance of wakefulness test, and full-night polysomnography. Anthropometric measurements and fasting blood samples were obtained, including fasting glucose and insulin, total cholesterol and its subfractions [low-density lipoprotein, very low-density lipoprotein, and low-density lipoprotein cholesterol (HDL-c)], triglycerides (TG), and the TG/HDL-c ratio. In addition, the quantitative insulin sensitivity check index and homeostasis model assessment indices were calculated. Thirty-two percent of mild OSA patients had MS, 43.5% of mild OSA patients had hypertension, 14% showed dyslipidemia, and 56% had prediabetes. The OSA group showed increased TG (CG: 90.0 ± 51.9 vs. OSA: 140.3 ± 78.2 mg/dL, P = 0.004), and TG/HDL-c (CG: 1.9 ± 1.4 vs. OSA: 3.1 ± 2.0, P = 0.05), independent of adjustments. Independent of obesity (BMI <30 kg/m 2 ), there was a negative correlation between total cholesterol and TG with mean oxygen saturation, independent of obesity (BMI <30 kg/m 2 ). Our findings showed dysregulation in lipid profiles after adjustments for confounders in the mild OSA group, and there was a correlation between these parameters and sleep hypoxemia. The TG/HDL-c ratio in particular was high, suggesting that it might be investigated as a marker of a detrimental metabolic profile in these patients.

Greenland annual accumulation along the EGIG line, 1959-2004, from ASIRAS airborne radar and neutron-probe density measurements

NASA Astrophysics Data System (ADS)

Overly, Thomas B.; Hawley, Robert L.; Helm, Veit; Morris, Elizabeth M.; Chaudhary, Rohan N.

2016-08-01

We report annual snow accumulation rates from 1959 to 2004 along a 250 km segment of the Expéditions Glaciologiques Internationales au Groenland (EGIG) line across central Greenland using Airborne SAR/Interferometric Radar Altimeter System (ASIRAS) radar layers and high resolution neutron-probe (NP) density profiles. ASIRAS-NP-derived accumulation rates are not statistically different (95 % confidence interval) from in situ EGIG accumulation measurements from 1985 to 2004. ASIRAS-NP-derived accumulation increases by 20 % below 3000 m elevation, and increases by 13 % above 3000 m elevation for the period 1995 to 2004 compared to 1985 to 1994. Three Regional Climate Models (PolarMM5, RACMO2.3, MAR) underestimate snow accumulation below 3000 m by 16-20 % compared to ASIRAS-NP from 1985 to 2004. We test radar-derived accumulation rates sensitivity to density using modeled density profiles in place of NP densities. ASIRAS radar layers combined with Herron and Langway (1980) model density profiles (ASIRAS-HL) produce accumulation rates within 3.5 % of ASIRAS-NP estimates in the dry snow region. We suggest using Herron and Langway (1980) density profiles to calibrate radar layers detected in dry snow regions of ice sheets lacking detailed in situ density measurements, such as those observed by the Operation IceBridge campaign.

Measurement of heat load density profile on acceleration grid in MeV-class negative ion accelerator.

PubMed

Hiratsuka, Junichi; Hanada, Masaya; Kojima, Atsushi; Umeda, Naotaka; Kashiwagi, Mieko; Miyamoto, Kenji; Yoshida, Masafumi; Nishikiori, Ryo; Ichikawa, Masahiro; Watanabe, Kazuhiro; Tobari, Hiroyuki

2016-02-01

To understand the physics of the negative ion extraction/acceleration, the heat load density profile on the acceleration grid has been firstly measured in the ITER prototype accelerator where the negative ions are accelerated to 1 MeV with five acceleration stages. In order to clarify the profile, the peripheries around the apertures on the acceleration grid were separated into thermally insulated 34 blocks with thermocouples. The spatial resolution is as low as 3 mm and small enough to measure the tail of the beam profile with a beam diameter of ∼16 mm. It was found that there were two peaks of heat load density around the aperture. These two peaks were also clarified to be caused by the intercepted negative ions and secondary electrons from detailed investigation by changing the beam optics and gas density profile. This is the first experimental result, which is useful to understand the trajectories of these particles.

Plasma Profile Measurements for Laser Fusion Research with the Nike KrF Laser

NASA Astrophysics Data System (ADS)

Oh, Jaechul; Weaver, J. L.; Serlin, V.; Obenschain, S. P.

2015-11-01

The grid image refractometer of the Nike laser facility (Nike-GIR) has demonstrated the capability of simultaneously measuring electron density (ne) and temperature (Te) profiles of coronal plasma. For laser plasma instability (LPI) research, the first Nike-GIR experiment successfully measured the plasma profiles in density regions up to ne ~ 4 ×1021 cm-3 (22% of the critical density for 248 nm light of Nike) using an ultraviolet probe laser (λp = 263 nm). The probe laser has been recently replaced with a shorter wavelength laser (λp = 213 nm, a 5th harmonic of the Nd:YAG laser) to diagnose a higher density region. The Nike-GIR system is being further extended to measure plasma profiles in the on-going experiment using 135°-separated Nike beam arrays for the cross-beam energy transfer (CBET) studies. We present an overview of the extended Nike-GIR arrangements and a new numerical algorithm to extract self-consistant plasma profiles with the measured quantities. Work supported by DoE/NNSA.

Facies-dependent variations in sediment physical properties on the Mississippi River Delta Front, USA: evidence for depositional and post-depositional processes

NASA Astrophysics Data System (ADS)

Smith, J. E., IV; Bentley, S. J.; Courtois, A. J.; Obelcz, J.; Chaytor, J. D.; Maloney, J. M.; Georgiou, I. Y.; Xu, K.; Miner, M. D.

2017-12-01

Recent studies on Mississippi River Delta have documented sub-aerial land loss, driven in part by declining sediment load over the past century. Impacts of changing sediment load on the subaqueous delta are less well known. The subaqueous Mississippi River Delta Front is known to be shaped by extensive submarine mudflows operating at a range of temporal and spatial scales, however impacts of changing sediment delivery on mudflow deposits have not been investigated. To better understand seabed morphology and stratigraphy as impacted by plume sedimentation and mudflows, an integrated geological/geophysical study was undertaken in delta front regions offshore the three main passes of the Mississippi River Delta. This study focuses on stratigraphy and physical properties of 30 piston cores (5-9 m length) collected in June 2017. Coring locations were selected in gully, lobe and prodelta settings based on multibeam bathymetry and seismic profiles collected in mid-May 2017. Cores were analyzed for density, magnetic susceptibility, P-wave speed, and resistivity using a Geotek multi sensor core logger; here, we focus on density data. Core density profiles generally vary systematically across facies. Density profiles of gully cores are nearly invariant with some downward stepwise increases delineating units meters thick, and abundant gaps likely caused by gas expansion. Lobe cores generally have subtle downward increases in density, some stepwise density increases, and fewer gaps. Prodelta cores show more pronounced downward density increases, decimeter-scale peaks and valleys in density profiles, but stepwise increases are less evident. We hypothesize that density profiles in gully and lobe settings (uniform profiles except for stepwise increases) reflect remolding by mudflows, whereas density variations in prodelta settings instead reflect grain size variations (decimeter-scale) and more advanced consolidation (overall downward density increase) consistent with slower sediment deposition. These hypotheses will be evaluated by a more detailed study of seismic stratigraphy and core properties, including geochronology, grain size distribution and X-radiographic imaging, to further relate important sedimentary processes with resulting deposits.

Estimating the D-Region Ionospheric Electron Density Profile Using VLF Narrowband Transmitters

NASA Astrophysics Data System (ADS)

Gross, N. C.; Cohen, M.

2016-12-01

The D-region ionospheric electron density profile plays an important role in many applications, including long-range and transionospheric communications, and coupling between the lower atmosphere and the upper ionosphere occurs, and estimation of very low frequency (VLF) wave propagation within the earth-ionosphere waveguide. However, measuring the D-region ionospheric density profile has been a challenge. The D-region is about 60 to 90 [km] in altitude, which is higher than planes and balloons can fly but lower than satellites can orbit. Researchers have previously used VLF remote sensing techniques, from either narrowband transmitters or sferics, to estimate the density profile, but these estimations are typically during a short time frame and over a single propagation path.We report on an effort to construct estimates of the D-region ionospheric electron density profile over multiple narrowband transmission paths for long periods of time. Measurements from multiple transmitters at multiple receivers are analyzed concurrently to minimize false solutions and improve accuracy. Likewise, time averaging is used to remove short transient noise at the receivers. The cornerstone of the algorithm is an artificial neural network (ANN), where input values are the received amplitude and phase for the narrowband transmitters and the outputs are the commonly known h' and beta two parameter exponential electron density profile. Training data for the ANN is generated using the Navy's Long-Wavelength Propagation Capability (LWPC) model. Results show the algorithm performs well under smooth ionospheric conditions and when proper geometries for the transmitters and receivers are used.

The impact of spherical symmetry assumption on radio occultation data inversion in the ionosphere: An assessment study

NASA Astrophysics Data System (ADS)

Shaikh, M. M.; Notarpietro, R.; Nava, B.

2014-02-01

'Onion-peeling' is a very common technique used to invert Radio Occultation (RO) data in the ionosphere. Because of the implicit assumption of spherical symmetry for the electron density (N(e)) distribution in the ionosphere, the standard Onion-peeling algorithm could give erroneous concentration values in the retrieved electron density profile. In particular, this happens when strong horizontal ionospheric electron density gradients are present, like for example in the Equatorial Ionization Anomaly (EIA) region during high solar activity periods. In this work, using simulated RO Total Electron Content (TEC) data computed by means of the NeQuick2 ionospheric electron density model and ideal RO geometries, we tried to formulate and evaluate an asymmetry level index for quasi-horizontal TEC observations. The asymmetry index is based on the electron density variation that a signal may experience along its path (satellite to satellite link) in a RO event and is strictly dependent on the occultation geometry (e.g. azimuth of the occultation plane). A very good correlation has been found between the asymmetry index and errors related to the inversion products, in particular those concerning the peak electron density NmF2 estimate and the Vertical TEC (VTEC) evaluation.

Detection of an electron beam in a high density plasma via an electrostatic probe

NASA Astrophysics Data System (ADS)

Majeski, Stephen; Yoo, Jongsoo; Zweben, Stewart; Yamada, Masaaki

2018-07-01

An electron beam is detected by a 1D floating potential probe array in a relatively high density (1012–1013 cm‑3) and low temperature (∼5 eV) plasma of the Magnetic Reconnection Experiment. Clear perturbations in the floating potential profile by the electron beam are observed. Based on the floating potential profile and a current balance equation to the probe array tips, the effective width of the electron beam is determined, from which we determine the radial and toroidal beam current density profiles. After the profile of the electron beam is specified from the measured beam current, we demonstrate the consistency of the current balance equation and the location of the perturbation is also in agreement with field line mapping. No significant broadening of the electron beam is observed after the beam propagates for tens of centimeters through the high density plasma. These results prove that the field line mapping is, in principle, possible in high density plasmas.

Detection of an electron beam in a high density plasma via an electrostatic probe

DOE Office of Scientific and Technical Information (OSTI.GOV)

Majeski, Stephen; Yoo, Jongsoo; Zweben, Stewart

Here, an electron beam is detected by a 1D floating potential probe array in a relatively high density (10 12–10 13 cm -3) and low temperature (~5 eV) plasma of the Magnetic Reconnection Experiment. Clear perturbations in the floating potential profile by the electron beam are observed. Based on the floating potential profile and a current balance equation to the probe array tips, the effective width of the electron beam is determined, from which we determine the radial and toroidal beam current density profiles. After the profile of the electron beam is specified from the measured beam current, we demonstratemore » the consistency of the current balance equation and the location of the perturbation is also in agreement with field line mapping. No significant broadening of the electron beam is observed after the beam propagates for tens of centimeters through the high density plasma. These results prove that the field line mapping is, in principle, possible in high density plasmas.« less

Detection of an electron beam in a high density plasma via an electrostatic probe

DOE PAGES

Majeski, Stephen; Yoo, Jongsoo; Zweben, Stewart; ...

2018-05-08

Here, an electron beam is detected by a 1D floating potential probe array in a relatively high density (10 12–10 13 cm -3) and low temperature (~5 eV) plasma of the Magnetic Reconnection Experiment. Clear perturbations in the floating potential profile by the electron beam are observed. Based on the floating potential profile and a current balance equation to the probe array tips, the effective width of the electron beam is determined, from which we determine the radial and toroidal beam current density profiles. After the profile of the electron beam is specified from the measured beam current, we demonstratemore » the consistency of the current balance equation and the location of the perturbation is also in agreement with field line mapping. No significant broadening of the electron beam is observed after the beam propagates for tens of centimeters through the high density plasma. These results prove that the field line mapping is, in principle, possible in high density plasmas.« less

Status of the Topside Vary-Chap Ionospheric Model

NASA Astrophysics Data System (ADS)

Reinisch, Bodo; Nsumei, Patrick; Huang, Xueqin; Bilitza, Dieter

Status of the Topside Vary-Chap Ionospheric Model The general alpha-Chapman function for a multi-constituent gas which includes a continuously varying scale height and was therefore dubbed the Vary-Chap function, can present the topside electron density profiles in analytical form. The Vary-Chap profile is defined by the scale height function H(h) and the height and density of the F2 layer peak. By expressing 80,000 ISIS-2 measured topside density profiles as Vary-Chap functions we derived 80,000 scale height functions, which form the basis for the topside density profile modeling. The normalized scale height profiles Hn = H(h)/Hm were grouped according to season, MLAT, and MLT for each 50 km height bin from 200 km to 1400 km, and the median, lower, and upper quartiles for each bin were calculated. Hm is the scale height at the F2 layer peak. The resulting Hn functions are modeled in terms of hyperbolic tangent functions using 5 parameters that are determined by multivariate least squares, including the transition height hT where the scale height gradient has a maximum. These normalized scale height functions, representing the model of the topside electron density profiles from hmF2 to 1,400 km altitude, are independent of hmF2 and NmF2 and can therefore be directly used for the topside Ne profile in IRI. Similarly, this model can extend measured bottomside profiles to the topside, replacing the simple alpha-Chapman function with constant scale height that is currently used for construction of the topside profile in the Digisondes / ARTIST of the Global Ionospheric Radio Observatory (GIRO). It turns out that Hm(top) calculated from the topside profiles is generally several times larger than Hm(bot) derived from the bottomside profiles. This follows necessarily from the difference in the definition of the scale height functions for the topside and bottomside profiles. The diurnal variations of the ratio Hm(top) / Hm(bot) has been determined for different latitudes which makes it now possible to specify the topside profile for any given bottomside profile.

Gaseous hydrogen/oxygen injector performance characterization

NASA Technical Reports Server (NTRS)

Degroot, W. A.; Tsuei, H. H.

1994-01-01

Results are presented of spontaneous Raman scattering measurements in the combustion chamber of a 110 N thrust class gaseous hydrogen/oxygen rocket. Temperature, oxygen number density, and water number density profiles at the injector exit plane are presented. These measurements are used as input profiles to a full Navier-Stokes computational fluid dynamics (CFD) code. Predictions of this code while using the measured profiles are compared with predictions while using assumed uniform injector profiles. Axial and radial velocity profiles derived from both sets of predictions are compared with Rayleigh scattering measurements in the exit plane of a 33:1 area ratio nozzle. Temperature and number density Raman scattering measurements at the exit plane of a test rocket with a 1:1.36 area ratio nozzle are also compared with results from both sets of predictions.

Radiation tolerant 1 micron CMOS technology

NASA Astrophysics Data System (ADS)

Crevel, P.; Rodde, K.

1991-03-01

Starting from a standard one micron Complementary Metal Oxide Semiconductor (CMOS) for high density, low power memory applications, the degree of radiation tolerance of the baseline process is evaluated. Implemented process modifications to improve latchup sensitivity under heavy ion irradiation as well as total dose effects without changing layout rules are described. By changing doping profiles in Metal Nitride Oxide Semiconductors (MNOS) and P-channel MOS (PMOS) device regions, it is possible to guarantee data sheet specification of a 64 K low power static RAM for total gamma dose up to 35 krad (Si) (and even higher values for the gate array family) without latch up for Linear Energy Transfer LET up to 115 MeV/(mg/cm squared).

BMI, total and abdominal fat distribution, and cardiovascular risk factors in school-age children.

PubMed

Gishti, Olta; Gaillard, Romy; Durmus, Busra; Abrahamse, Marieke; van der Beek, Eline M; Hofman, Albert; Franco, Oscar H; de Jonge, Layla L; Jaddoe, Vincent W V

2015-05-01

More specific total body and abdominal fat mass measures might be stronger associated with cardiovascular risk factors in childhood, than BMI. We examined the independent associations of total and abdominal fat measures with cardiovascular risk factors in school age children. We performed a population-based cohort study among 6,523 children. At the age of 6 y, we measured childhood BMI, and general and abdominal fat mass, using dual-energy X-ray absorptiometry, and ultrasound and cardiovascular risk factors. Conditional on BMI, higher fat mass percentage and abdominal fat mass were associated with higher blood pressure, total- and low-density lipoprotein (LDL)-cholesterol, insulin and c-peptide levels, but with lower left ventricular mass and high-density lipoprotein (HDL)-cholesterol (P values < 0.05). These associations differed between underweight, normal weight, overweight, and obese children. Higher childhood adiposity measures were associated with increased odds of cardiovascular risk factors clustering, with the strongest effect for fat mass percentage (odds ratios: 3.01 (95% confidence interval: 2.67, 3.9). Our results suggest that general and abdominal fat measures are associated with cardiovascular risk factors in childhood, independent from BMI. These measures may provide additional information for identification of children with an adverse cardiovascular profile.

Recovery after shift work: Relation to coronary risk factors in women.

PubMed

Axelsson, John; Lowden, Arne; Kecklund, Göran

2006-01-01

Shift work increases the risk for developing cardiovascular disease. There is, however, little knowledge of what aspects of shift scheduling that are detrimental and what characteristics promote good health. The aim of the present study was to evaluate whether coronary risk factors deteriorate after a hard work period and whether recovery, in the form of a week off, was sufficient to improve them. A total of 19 women worked an extremely rapidly rotating and clockwise shift schedule at a paper and pulp factory. They underwent two health examinations, one at the end of the work period and one after the week off. In addition, the women were divided into a tolerant and a vulnerable group, depending on their satisfaction with their work hours. Most risk factors did not change, but total cholesterol and low-density lipoprotein (LDL)-cholesterol were lower after the working period than after the week-off. In addition, vulnerable women had higher levels of total cholesterol and a higher ratio of total cholesterol/high-density lipoprotein (HDL) than tolerant ones. In conclusion, the finding that a week-off worsens cholesterol levels was against our hypothesis and suggests further studies on how activities/responsibilities outside the workplace affect shift-working women. It was also shown that susceptible shift workers had worse lipid profiles.

Nutrient profile of 23 596 packaged supermarket foods and non-alcoholic beverages in Australia and New Zealand.

PubMed

Ni Mhurchu, Cliona; Brown, Ryan; Jiang, Yannan; Eyles, Helen; Dunford, Elizabeth; Neal, Bruce

2016-02-01

To compare the nutrient profile of packaged supermarket food products available in Australia and New Zealand. Eligibility to carry health claims and relationship between nutrient profile score and nutritional content were also evaluated. Nutritional composition data were collected in six major Australian and New Zealand supermarkets in 2012. Mean Food Standards Australia New Zealand Nutrient Profiling Scoring Criterion (NPSC) scores were calculated and the proportion of products eligible to display health claims was estimated. Regression analyses quantified associations between NPSC scores and energy density, saturated fat, sugar and sodium contents. NPSC scores were derived for 23,596 packaged food products (mean score 7.0, range -17 to 53). Scores were lower (better nutrient profile) for foods in Australia compared with New Zealand (mean 6.6 v. 7.8). Overall, 45% of foods were eligible to carry health claims based on NPSC thresholds: 47% in Australia and 41% in New Zealand. However, less than one-third of dairy (32%), meat and meat products (28%) and bread and bakery products (27.5%) were eligible to carry health claims. Conversely, >75% of convenience food products were eligible to carry health claims (82.5%). Each two-unit higher NPSC score was associated with higher energy density (78 kJ/100 g), saturated fat (0.95 g/100 g), total sugar (1.5 g/100 g) and sodium (66 mg/100 g; all P values<0.001). Fewer than half of all packaged foods available in Australia and New Zealand in 2012 met nutritional criteria to carry health claims. The few healthy choices available in key staple food categories is a concern. Improvements in nutritional quality of foods through product reformulation have significant potential to improve population diets.

Influence of a walking program on the metabolic risk profile of obese postmenopausal women.

PubMed

Roussel, Michel; Garnier, Sophie; Lemoine, Sophie; Gaubert, Isabelle; Charbonnier, Laurie; Auneau, Gérard; Mauriège, Pascale

2009-01-01

Menopause transition is associated with an increased prevalence of metabolic syndrome (MS), which may partly explain the higher coronary heart disease risk. The aim of this study was to examine the impact of a 16-week walking program on the metabolic risk profile of women 50 to 65 years old whose body mass index ranged from 29 to 35 kg/m. A total of 153 postmenopausal women were subjected to three sessions per week of 45-minutes of walking at 60% of their heart rate reserve. At baseline, 46 and 84 women were characterized by one and two or more determinants of MS, respectively, whereas 23 women did not show this condition. Body composition, resting blood pressure, fasting lipid-lipoprotein profile, and cardiorespiratory fitness (CRF) were measured before and after exercise. In the whole sample of 153 women, CRF estimated by V(O2max) increased in response to walking (P < 0.0001). Endurance training promoted body weight and fat mass losses and reduced waist girth and blood pressure, whereas it decreased plasma triglyceride, cholesterol, and low-density lipoprotein cholesterol levels and increased high-density lipoprotein cholesterol concentrations (P < 0.0001). Improvements in lipid-lipoprotein levels were not associated with increases in CRF but seemed to be dependent on reduced body fatness. However, the greatest ameliorations in metabolic risk profile were found in women characterized by two or more determinants of MS at baseline than in the two other groups (0.05 < P < 0.0001). A moderate-intensity physical activity is thus sufficient to reduce the metabolic risk profile of postmenopausal women characterized by the presence of one or several clinical features of MS but without overt coronary heart disease.

Packaged Food Purchases at Walmart and Other Food Retail Chains Changes In Nutritional Profile From 2000 to 2013

PubMed Central

Taillie, Lindsey Smith; Ng, Shu Wen; Popkin, Barry M.

2015-01-01

Introduction Proliferation of food retail chains has created an environment in which a few food retailers account for the majority of U.S. packaged food purchases (PFPs). Despite the major potential for these food retail chains (FRCs) to impact what U.S. consumers buy and eat, little is known about the nutritional profile of PFPs from these retailers, particularly PFPs from Walmart, the U.S.’ largest grocer. Methods A data set of household PFPs from Nielsen Homescan was linked to data from the Nutrition Facts Panel (N=164,315), analyzed in 2014. Fixed effects models and inverse probability weights accounting for selectivity of shopping at a retailer were used to examine shifts in nutrient densities and key food groups purchased at Walmart and other FRCs from 2000 to 2013, and whether these changes differed for low-income or race/ethnic minority households. Results There were substantial declines in energy (−73 kcal/100 g), total sugar (−8 g/100 g), and sodium density (−33 mg/100 g) of Walmart PFPs, coupled with decreases in percentage volume purchased from sweets (−11%), grain-based desserts (−2%), and savory snacks (−3%) and increases in fruits (+3%) and vegetables (+1%). PFPs from other FRCs had a more favorable nutritional profile than Walmart PFPs in 2000, but demonstrated smaller shifts over time. Disparities in the nutritional profile of Walmart PFPs by race/ethnicity but not by income level shrank over time. Conclusions The nutritional profile of Walmart purchases has improved over time and in 2013 was similar to PFPs from other FRCs. PMID:26497262

Walmart and Other Food Retail Chains: Trends and Disparities in the Nutritional Profile of Packaged Food Purchases.

PubMed

Taillie, Lindsey Smith; Ng, Shu Wen; Popkin, Barry M

2016-02-01

Proliferation of food retail chains has created an environment in which a few food retailers account for the majority of U.S. packaged food purchases (PFPs). Despite the major potential for these food retail chains (FRCs) to impact what U.S. consumers buy and eat, little is known about the nutritional profile of PFPs from these retailers, particularly PFPs from Walmart, the largest U.S. grocer. A data set of household PFPs from Nielsen Homescan was linked to data from the Nutrition Facts Panel (N=164,315), analyzed in 2014. Fixed effects models and inverse probability weights accounting for selectivity of shopping at a retailer were used to examine shifts in nutrient densities and key food groups purchased at Walmart and other FRCs from 2000 to 2013, and whether these changes differed for low-income or racial/ethnic-minority households. There were substantial declines in energy (-73 kcal/100 g); total sugar (-8 g/100 g); and sodium density (-33 mg/100 g) of Walmart PFPs, coupled with decreases in percentage volume purchased from sweets (-11%); grain-based desserts (-2%); and savory snacks (-3%) and increases in fruits (+3%) and vegetables (+1%). PFPs from other FRCs had a more favorable nutritional profile than Walmart PFPs in 2000, but demonstrated smaller shifts over time. Disparities in the nutritional profile of Walmart PFPs by race/ethnicity but not by income level shrank over time. The nutritional profile of Walmart purchases has improved over time and in 2013 was similar to PFPs from other FRCs. Copyright © 2016 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

Satellite Galaxies in the Illustris-1 Simulation: Poor Tracers of the Underlying Mass Distribution

NASA Astrophysics Data System (ADS)

Brainerd, Tereasa G.

2018-06-01

The 3-d spatial distribution of luminous satellite galaxies in the z=0 snapshot of the Illustris-1 simulation is compared to the 3-d spatial distribution of the mass surrounding the primary galaxies about which the satellites orbit. The primary-satellite sample is selected in such a way that it matches the selection criteria used in a previous study of luminous satellite galaxies in the Millennium Run simulation. A key difference between the two simulations is that luminous galaxies in the Millennium Run are the result of a semi-analytic galaxy formation model, while in Illustris-1 the luminous galaxies are the result of numerical hydrodynamics, star formation and feedback models. The sample consists of 1,025 primary galaxies with absolute magnitudes Mr < -20.5, and there are a total of 4,546 satellites with absolute magnitudes Mr < -14.5 within the virial radii of the primary galaxies. The mass distribution surrounding the primary galaxies is well fitted by an NFW profile with a concentration parameter c = 11.9. Contrary to a previous study using satellite galaxies in the Millennium Run, the number density profile of the full satellite sample from Illustris-1 is not at all well-fitted by an NFW profile. In the case of the faintest satellites (Mr > -17), the satellite number density profile is well-fitted by an NFW profile, but the concentration parameter is exceptionally low (c = 1.8) compared to the concentration parameter of the mass surrounding the primary galaxies. The conclusion from this work is that luminous satellite galaxies in Illustris-1 are poor tracers of the mass distribution surrounding their primary galaxies.

Effect of oral contraceptive containing ethinyl estradiol combined with drospirenone vs. desogestrel on clinical and biochemical parameters in patients with polycystic ovary syndrome.

PubMed

Kriplani, Alka; Periyasamy, Anurekha Janaki; Agarwal, Nutan; Kulshrestha, Vidushi; Kumar, Anand; Ammini, Ariachery Chinnama

2010-08-01

A prospective randomized trial was conducted to compare efficacy of a drospirenone-containing combined oral contraceptives (COC) with desogestrel-containing COC in women with polycystic ovary-syndrome (PCOS) not desirous of child-bearing. Sixty women were randomized into study group [ethinylestradiol (EE) 30 mcg+drospirenone 3 mg] and control group (EE 30 mcg+desogestrel 150 mcg), treated for 6 months and followed up at 1 month, 3 months, 6 months, during treatment and 3 and 6 months post-treatment. Acne and hirsutism scoring, bodyweight, body mass index (BMI), blood pressure (BP), ultrasound parameters, lipid profile, glycemic profile and hormonal profile were compared. Cycles were regular in both groups during treatment. Effect of regular cycles persisted in 44.83% (13/30) vs. 17.24% (5/30) in study vs. control group at 6 months post-treatment with 33.3% decreased hirsutism score in the study group (versus no change in control group) even at 6 months after stopping treatment. With treatment, BMI fell by 0.52 kg/m(2) in the study group; systolic and diastolic BP fell in the study group while it rose in the control group. Low-density lipoprotein significantly decreased and high-density lipoprotein was elevated in the study group (p<.05). The study group showed a significant fall in fasting/postprandial blood sugar and insulin and total testosterone against a rise in the control group. In women with PCOS, a drospirenone containing COC has better outcome in terms of persistent regular cycles, antiandrogenic effect, fall in BMI and BP, better lipid profile, favorable glycemic and hormonal profile than desogestrel-containing COC. Copyright 2010 Elsevier Inc. All rights reserved.

Radial dependence of the dark matter distribution in M33

NASA Astrophysics Data System (ADS)

López Fune, E.; Salucci, P.; Corbelli, E.

2017-06-01

The stellar and gaseous mass distributions, as well as the extended rotation curve, in the nearby galaxy M33 are used to derive the radial distribution of dark matter density in the halo and to test cosmological models of galaxy formation and evolution. Two methods are examined to constrain the dark mass density profiles. The first method deals directly with fitting the rotation curve data in the range of galactocentric distances 0.24 ≤ r ≤ 22.72 kpc. Using the results of collisionless Λ cold dark matter numerical simulations, we confirm that the Navarro-Frenkel-White (NFW) dark matter profile provides a better fit to the rotation curve data than the cored Burkert profile (BRK) profile. The second method relies on the local equation of centrifugal equilibrium and on the rotation curve slope. In the aforementioned range of distances, we fit the observed velocity profile, using a function that has a rational dependence on the radius, and we derive the slope of the rotation curve. Then, we infer the effective matter densities. In the radial range 9.53 ≤ r ≤ 22.72 kpc, the uncertainties induced by the luminous matter (stars and gas) become negligible, because the dark matter density dominates, and we can determine locally the radial distribution of dark matter. With this second method, we tested the NFW and BRK dark matter profiles and we can confirm that both profiles are compatible with the data, even though in this case the cored BRK density profile provides a more reasonable value for the baryonic-to-dark matter ratio.

Density variations and their influence on carbon stocks: case-study on two Biosphere Reserves in the Democratic Republic of Congo

NASA Astrophysics Data System (ADS)

De Ridder, Maaike; De Haulleville, Thalès; Kearsley, Elizabeth; Van den Bulcke, Jan; Van Acker, Joris; Beeckman, Hans

2014-05-01

It is commonly acknowledged that allometric equations for aboveground biomass and carbon stock estimates are improved significantly if density is included as a variable. However, not much attention is given to this variable in terms of exact, measured values and density profiles from pith to bark. Most published case-studies obtain density values from literature sources or databases, this way using large ranges of density values and possible causing significant errors in carbon stock estimates. The use of one single fixed value for density is also not recommended if carbon stock increments are estimated. Therefore, our objective is to measure and analyze a large number of tree species occurring in two Biosphere Reserves (Luki and Yangambi). Nevertheless, the diversity of tree species in these tropical forests is too high to perform this kind of detailed analysis on all tree species (> 200/ha). Therefore, we focus on the most frequently encountered tree species with high abundance (trees/ha) and dominance (basal area/ha) for this study. Increment cores were scanned with a helical X-ray protocol to obtain density profiles from pith to bark. This way, we aim at dividing the tree species with a distinct type of density profile into separate groups. If, e.g., slopes in density values from pith to bark remain stable over larger samples of one tree species, this slope could also be used to correct for errors in carbon (increment) estimates, caused by density values from simplified density measurements or density values from literature. In summary, this is most likely the first study in the Congo Basin that focuses on density patterns in order to check their influence on carbon stocks and differences in carbon stocking based on species composition (density profiles ~ temperament of tree species).

MAVEN in situ measurements of photochemical escape of oxygen from Mars

NASA Astrophysics Data System (ADS)

Lillis, Robert; Deighan, Justin; Fox, Jane; Bougher, Stephen; Lee, Yuni; Cravens, Thomas; Rahmati, Ali; Mahaffy, Paul; Benna, Mehdi; Groller, Hannes; Jakosky, Bruce

2016-04-01

One of the primary goals of the MAVEN mission is to characterize rates of atmospheric escape from Mars at the present epoch and relate those escape rates to solar drivers. One of the known escape processes is photochemical escape, where a) an exothermic chemical reaction in the atmosphere results in an upward-traveling neutral particle whose velocity exceeds planetary escape velocity and b) the particle is not prevented from escaping through subsequent collisions. At Mars, photochemical escape of oxygen is expected to be a significant channel for atmospheric escape, particularly in the early solar system when extreme ultraviolet (EUV) fluxes were much higher. Thus characterizing this escape process and its variability with solar drivers is central to understanding the role escape to space has played in Mars' climate evolution. We use near-periapsis (<400 km altitude) data from three MAVEN instruments: the Langmuir Probe and Waves (LPW) instrument measures electron density and temperature, the Suprathermal And Thermal Ion Composition (STATIC) experiment measures ion temperature and the Neutral Gas and Ion Mass Spectrometer (NGIMS) measures neutral and ion densities. For each profile of in situ measurements, we make several calculations, each as a function of altitude. The first uses electron and temperatures and simulates the dissociative recombination of both O2+ and CO2+ to calculate the probability distribution for the initial energies of the resulting hot oxygen atoms. The second is a Monte Carlo hot atom transport model that takes that distribution of initial O energies and the measured neutral density profiles and calculates the probability that a hot atom born at that altitude will escape. The third takes the measured electron and ion densities and electron temperatures and calculates the production rate of hot O atoms. We then multiply together the profiles of hot atom production and escape probability to get profiles of the production rate of escaping atoms. We integrate with respect to altitude to give us the escape flux of hot oxygen atoms for that periapsis pass. We have sufficient coverage in solar zenith angle (SZA) to estimate total escape rates for two intervals with the obvious assumption that escape rates are the same at all points with the same SZA. We estimate total escape rates of 3.5-5.8 x 1025 s-1 for Ls = 289° to 319° and 1.6-2.6 x 1025 s-1 for Ls = 326° to 348°. The latter is the most directly comparable to previous model-based estimates and is roughly in line with several of them. Total photochemical loss over Mars history is not very useful to calculate from such escape fluxes derived over a limited area and under limited conditions. A thicker atmosphere and much higher solar EUV in the past may change the dynamics of escape dramatically. In the future, we intend to use 3-D Monte Carlo models of global atmospheric escape, in concert with our in situ and remote measurements, to fully characterize photochemical escape under current conditions and carefully extrapolate back in time using further simulations with new boundary conditions.

Copernicus atmospheric service for stratospheric ozone: validation and intercomparison of four near real-time analyses, 2009-2012

NASA Astrophysics Data System (ADS)

Lefever, K.; van der A, R.; Baier, F.; Christophe, Y.; Errera, Q.; Eskes, H.; Flemming, J.; Inness, A.; Jones, L.; Lambert, J.-C.; Langerock, B.; Schultz, M. G.; Stein, O.; Wagner, A.; Chabrillat, S.

2014-05-01

This paper evaluates the performance of the stratospheric ozone analyses delivered in near real time by the MACC (Monitoring Atmospheric Composition and Climate) project during the 3 year period between September 2009 and September 2012. Ozone analyses produced by four different chemistry transport models and data assimilation techniques are examined: the ECMWF Integrated Forecast System (IFS) coupled to MOZART-3 (IFS-MOZART), the BIRA-IASB Belgian Assimilation System for Chemical ObsErvations (BASCOE), the DLR/RIU Synoptic Analysis of Chemical Constituents by Advanced Data Assimilation (SACADA), and the KNMI Data Assimilation Model based on Transport Model version 3 (TM3DAM). The assimilated satellite ozone retrievals differed for each system: SACADA and TM3DAM assimilated only total ozone observations, BASCOE assimilated profiles for ozone and some related species, while IFS-MOZART assimilated both types of ozone observations. The stratospheric ozone analyses are compared to independent ozone observations from ground-based instruments, ozone sondes and the ACE-FTS (Atmospheric Chemistry Experiment - Fourier Transform Spectrometer) satellite instrument. All analyses show total column values which are generally in good agreement with groundbased observations (biases <5%) and a realistic seasonal cycle. The only exceptions are found for BASCOE which systematically underestimates total ozone in the Tropics with about 7-10% at Chengkung (Taiwan, 23.1° N/121.365° E), resulting from the fact that BASCOE does not include any tropospheric processes, and for SACADA which overestimates total ozone in the absence of UV observations for the assimilation. Due to the large weight given to column observations in the assimilation procedure, IFS-MOZART is able to reproduce total column observations very well, but alternating positive and negative biases compared to ozonesonde and ACE-FTS satellite data are found in the vertical as well as an overestimation of 30 to 60% in the polar lower stratosphere during ozone depletion events. The assimilation of near real-time (NRT) Microwave Limb Sounder (MLS) profiles which only go down to 68 hPa is not able to correct for the deficiency of the underlying MOZART model, which may be related to the applied meteorological fields. Biases of BASCOE compared to ozonesonde or ACE-FTS ozone profiles do not exceed 10% over the entire vertical stratospheric range, thanks to the good performance of the model in ozone hole conditions and the assimilation of offline MLS profiles going down to 215 hPa. TM3DAM provides very realistic total ozone columns, but is not designed to provide information on the vertical distribution of ozone. Compared to ozonesondes and ACE-FTS satellite data, SACADA performs best in the Arctic, but shows large biases (>50%) for ozone in the lower stratosphere in the Tropics and in the Antarctic, especially during ozone hole conditions. This study shows that ozone analyses with realistic total ozone column densities do not necessarily yield good agreement with the observed ozone profiles. It also shows the large benefit obtained from the assimilation of a single limb-scanning instrument (Aura MLS) with a high density of observations. Hence even state-of-the-art models of stratospheric chemistry still require the assimilation of limb observations for a correct representation of the vertical distribution of ozone in the stratosphere.

Where does the plasmasphere begin? Revisit to topside ionospheric profiles in comparison with plasmaspheric TEC from Jason-1

NASA Astrophysics Data System (ADS)

Lee, Han-Byul; Kim, Yong Ha; Kim, Eunsol; Hong, Junseok; Kwak, Young-Sil

2016-10-01

Topside ionospheric profiles have been measured by Alouette 1 and ISIS 1/2 in the periods of 1962-1972 and 1972-1979, respectively. The profiles cover from the orbital altitude of 1000 km to the F2 peak and show large variations over local time, latitude, and seasons. We here analyze these variations in comparison with plasmaspheric total electron contents (pTECs) that were measured by Jason-1 satellite from the altitude of 1336 km to 20,200 km (GPS orbit). The scale heights of the profiles are generally smaller in the daytime than nighttime but show large day-to-day variations, implying that the ionospheric profiles at 1000 km are changing dynamically, rather than being in diffusive equilibrium. We also derived transition heights between O+ and H+, which show a clear minimum at dawn for low-latitude profiles due to decreasing O+ density at night. To compare with pTEC, we compute topside ionospheric total electron content (tiTEC) by integrating over 800-1336 km using the slope of the profiles. The tiTEC varies in a clear diurnal pattern from 0.3 to 1 and 3 total electron content unit (TECU, 1 TECU = 1016 el m-2) for low and high solar activity, respectively, whereas Jason-1 pTEC values are distributed over 2-6 TECU and 4-8 TECU for low and high solar activity, respectively, with no apparent diurnal modulation. Latitudinal variations of tiTEC show distinctive hemispheric asymmetry while that of Jason-1 pTEC is closely symmetric about the magnetic equator. The local time and latitudinal variations of tiTEC basically resemble those of the ionosphere but are characteristically different from those of Jason-1 pTEC. Based on the difference between tiTEC and pTEC variations, we propose that the region above 1300 km should be considered as the plasmasphere. Lower altitudes for the base of "plasmaspheric TEC," as used in some studies, would cause contamination of ionospheric influence.

The hypolipidaemic effects of Spirulina (Arthrospira platensis) supplementation in a Cretan population: a prospective study.

PubMed

Mazokopakis, Elias E; Starakis, Ioannis K; Papadomanolaki, Maria G; Mavroeidi, Niki G; Ganotakis, Emmanuel S

2014-02-01

Spirulina (Arthrospira platensis) is a filamentous cyanobacterium used as a food supplement. The objective of the study was to determine the lipid-lowering effects of Spirulina in Cretan Greek dyslipidaemic patients, and to document its effectiveness as a possible alternative treatment for dyslipidaemia. Fifty-two adultCretan outpatients (32 men, 20 women), median age 47 (range, 37-61) years, with recently diagnosed dyslipidaemia, consumed orally 1 g Spirulina (Greek production) per day for 12 weeks. The full lipid profile was measured in fasting blood samples at the beginning and end of the study period. Anthropometric measurements including systolic and diastolic blood pressure, height, weight and body mass index were also recorded. At the end of the 3-month intervention period the mean levels of triglycerides, low density lipoprotein-cholesterol, total cholesterol, non-high density lipoprotein-cholesterol levels, and the ratio of total cholesterol to high-density lipoproteincholesterol were significantly decreased: 16.3% (P < 0.0001), 10.1% (P < 0.0001), 8.9% (P < 0.0001), 10.8% (P < 0.0001) and 11.5% (P = 0.0006) respectively, whereas the mean high-density lipoprotein-cholesterol levels were not significantly increased (3.5%). Blood pressure, weight and body mass index remained almost unchanged. Spirulina supplementation at a dose of 1 g daily has powerful hypolipidaemic effects, especially on the triglyceride concentration in dyslipidaemic Cretan outpatients. © 2013 Society of Chemical Industry.

A field-to-desktop toolchain for X-ray CT densitometry enables tree ring analysis

PubMed Central

De Mil, Tom; Vannoppen, Astrid; Beeckman, Hans; Van Acker, Joris; Van den Bulcke, Jan

2016-01-01

Background and Aims Disentangling tree growth requires more than ring width data only. Densitometry is considered a valuable proxy, yet laborious wood sample preparation and lack of dedicated software limit the widespread use of density profiling for tree ring analysis. An X-ray computed tomography-based toolchain of tree increment cores is presented, which results in profile data sets suitable for visual exploration as well as density-based pattern matching. Methods Two temperate (Quercus petraea, Fagus sylvatica) and one tropical species (Terminalia superba) were used for density profiling using an X-ray computed tomography facility with custom-made sample holders and dedicated processing software. Key Results Density-based pattern matching is developed and able to detect anomalies in ring series that can be corrected via interactive software. Conclusions A digital workflow allows generation of structure-corrected profiles of large sets of cores in a short time span that provide sufficient intra-annual density information for tree ring analysis. Furthermore, visual exploration of such data sets is of high value. The dated profiles can be used for high-resolution chronologies and also offer opportunities for fast screening of lesser studied tropical tree species. PMID:27107414

A Study to Assess the Therapeutic Effect of Enalapril on Olanzapine Induced Metabolic Syndrome in Wistar Rats.

PubMed

Arivazhahan, Avinash; Bairy, Laxminarayana Kurady; Nayak, Veena; Kunder, Sushil Kiran

2017-02-01

Metabolic Syndrome (MS) is a complex of risk factors for the development of cardiovascular complications and Type 2 Diabetes Mellitus (DM). Pharmacological management of the condition is complex, as multiple drug groups have to be used, as the syndrome itself is multi faceted. Angiotensin Converting Enzyme Inhibitors (ACEIs) are chiefly used to manage the hypertensive component of the syndrome. However, recent studies have shown that these drugs may have a role in the non hypertensive aspects of the syndrome as well. To evaluate the therapeutic effect of enalapril on total body weight, random blood glucose and serum lipid profile in a rodent model of olanzapine induced MS. Three different dosages (1 mg/kg/day, 10 mg/kg/day and 20 mg/kg/day) of oral enalapril were administered (for three weeks) in albino wistar rats, which received prior intra peritoneal olanzapine (for three weeks), and compared against control (normal saline) and standard (olanzapine only and enalapril only) groups. Parameters like total body weight, random blood glucose and serum lipid profile were measured at baseline, at three weeks and at six weeks. Enalapril at 20 mg/kg/day was found to be effective in reversing the weight gain, hyperglycaemia and hypercholesterolaemia, without any changes in triglycerides, High Density Lipoprotein (HDL) and Low Density Lipoprotein (LDL). 10 mg/kg/day of enalapril prevented any further rise in body weight, blood glucose, total cholesterol and serum triglycerides, after olanzapine was stopped. 1 mg/kg/day of enalapril was ineffective. High dose of enalapril may be considered as a component of therapeutic regimens to combat weight gain, hyperglycaemia and dyslipidaemia seen in MS, in addition to its antihypertensive utility. Further rodent and clinical studies may be required to ascertain the same.

High prevalence of dyslipidemia among primary care patients with hypertension and diabetes in Jamaica.

PubMed

Harris, Michelle A; Ferguson, Trevor S; Boyne, Michael S; Figueroa, J Peter

2017-01-01

The aim of the study was to determine the prevalence of dyslipidemia among primary care patients with hypertension and diabetes in Jamaica and the proportion of patients who achieve recommended targets. An audit of 500 dockets of adult patients with chronic disease attending public primary care clinics in Jamaica was conducted between October and December 2013. Data were collected on patient characteristics including medical history, medications, anthropometry, and lipid profiles (since January 1, 2011). Lipid targets were based on the Ministry of Health 2007 management guidelines. Stepwise multivariable logistic regression analysis was performed to determine the predictors of achieving lipid targets. Four hundred and thirty-seven patient records had a lipid profile done and 90% of these had at least one abnormal lipid value. 15.3% of the patients achieved the low density lipoprotein cholesterol (LDL-C) target, 63.2% high density lipoprotein cholesterol (HDL-C), 85.1% triglycerides and 57.4% the total cholesterol target. Statins were prescribed for 49% and these patients were less likely to achieve LDL-C (OR = 0.57; 95% CI: 0.33-0.97; p = 0.04) or total cholesterol (OR = 0.21; 95% CI: 0.13-0.33; p < 0.001) targets. Patients over 80 years were more likely to achieve the LDL-C target (OR = 3.21; 95% CI: 1.64-6.28; p = 0.002) than those less than 50 years old. More men than women achieved total cholesterol targets (OR = 2.2; 95% CI: 1.4-3.6; p = 0.001). Dyslipidemia is widespread among primary care patients with hypertension and diabetes. The proportion of patients who achieve the respective lipid targets must be documented and routinely monitored and appropriate medication and lifestyle changes implemented to improve this.

Doxazosin versus bendrofluazide: a comparison of the metabolic effects in British South Asians with hypertension

PubMed Central

Hobbs, FD Richard; Khan, Tahir; Collins, Barbara

2005-01-01

Background People from British South Asian communities have an increased risk of mortality from coronary heart disease (CHD). Doxazosin, a selective α1-adrenergic blocker, in addition to lowering blood pressure, has been shown to have positive effects on glucose metabolism and lipid profiles in patients with hypertension. Aim We studied doxazosin (1–8 mg) and bendrofluazide (2.5 mg) in patients of British South Asian origin with existing mild to moderate hypertension (doxazosin n = 78; bendrofluazide n = 82), to compare their effects on glucose and lipid metabolism in this group. Design of study A 34-week randomised, double-blind, parallel-group, multicentre study. Setting Primary care in the UK. Method All doxazosin patients started with an initial dose of 1 mg once daily, titrated to a maximum 8 mg once daily if diastolic blood pressure was >90 mmHg or was not <5 mmHg of the baseline value. The primary efficacy variables were mean glucose and total cholesterol concentrations at week 21. Result Doxazosin reduced glucose, total cholesterol, low-density lipoprotein-cholesterol and triglycerides and increased high-density lipoprotein-cholesterol. There were significant differences between doxazosin and bendrofluazide for glucose concentrations at week 21 (P = 0.029) and week 34 (P = 0.015), total cholesterol at week 21 (P = 0.048) and triglycerides at week 21 P = 0.047) and week 34 (P = 0.009). There was no significant difference in blood pressure lowering between the two treatments. Conclusion Doxazosin exhibits beneficial effects on glucose concentrations and lipid profile, in particular in lowering triglyceride concentrations in British South Asians. Whether these desirable characteristics translate to improved overall cardiovascular risk requires formal evaluation. PMID:15970067

Increased follistatin levels after oral contraceptive treatment in obese and non-obese women with polycystic ovary syndrome.

PubMed

Chen, Mei-Jou; Yang, Wei-Shiung; Chen, Hsin-Fu; Kuo, Jahn-Jahn; Ho, Hong-Nerng; Yang, Yu-Shih; Chen, Shee-Uan

2010-03-01

Follistatin levels have recently been considered as a marker for inflammation. Our objective was to evaluate the level of circulating follistatin and high-sensitivity C-reactive protein (hsCRP) in women with polycystic ovary syndrome (PCOS) after oral contraceptive (OC) treatment. A total of 56 Taiwanese women with PCOS were enrolled in this prospective observational study in which they were treated for 3 months with OCs (ethinyl estradiol-cyproterone acetate). Blood samples were taken at baseline after treatment during the withdrawal bleed. Body mass index (BMI), lipid profiles, plasma follistatin, hsCRP, fasting glucose, insulin for the homeostasis model assessment of insulin resistance (HOMA-IR) and hormone profiles were measured and analyzed. Total testosterone, free androgen index (FAI), dehydroepiandrosterone sulfate (DHEAS), follicle-stimulating hormone (FSH), luteinizing hormone (LH) and estradiol levels were significantly lower, but total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, circulating follistatin and hsCRP were significantly higher than baseline in women with PCOS after treatment with OCs. An elevation of fasting insulin, HOMA-IR and hsCRP after OC treatment was more evident in non-obese than obese women, whereas the elevation of follistatin was significant in both obese and non-obese women. Follistatin and hsCRP levels all showed significant correlations with each other at baseline and after treatment. The differences in follistatin and hsCRP levels from baseline to after OC treatment were significantly associated with the difference in triglyceride levels. Both hsCRP and follistatin levels increase after OC treatment in women with PCOS. Follistatin seems more sensitive than hsCRP alone to represent the aggravated low-grade inflammatory status after OC treatment in obese and non-obese women with PCOS.

Pharmacologic profile of the Adnectin BMS-962476, a small protein biologic alternative to PCSK9 antibodies for low-density lipoprotein lowering.

PubMed

Mitchell, Tracy; Chao, Ginger; Sitkoff, Doree; Lo, Fred; Monshizadegan, Hossain; Meyers, Daniel; Low, Simon; Russo, Katie; DiBella, Rose; Denhez, Fabienne; Gao, Mian; Myers, Joseph; Duke, Gerald; Witmer, Mark; Miao, Bowman; Ho, Siew P; Khan, Javed; Parker, Rex A

2014-08-01

Proprotein convertase subtilisin kexin-9 (PCSK9) is an important pharmacological target for decreasing low-density lipoprotein (LDL) in cardiovascular disease, although seemingly inaccessible to small molecule approaches. Compared with therapeutic IgG antibodies currently in development, targeting circulating PCSK9 with smaller molecular scaffolds could offer different profiles and reduced dose burdens. This inspired genesis of PCSK9-binding Adnectins, a protein family derived from human fibronectin-10th-type III-domain and engineered for high-affinity target binding. BMS-962476, an ∼11-kDa polypeptide conjugated to polyethylene glycol to enhance pharmacokinetics, binds with subnanomolar affinity to human. The X-ray cocrystal structure of PCSK9 with a progenitor Adnectin shows ∼910 Å(2) of PCSK9 surface covered next to the LDL receptor binding site, largely by residues of a single loop of the Adnectin. In hypercholesterolemic, overexpressing human PCSK9 transgenic mice, BMS-962476 rapidly lowered cholesterol and free PCSK9 levels. In genomic transgenic mice, BMS-962476 potently reduced free human PCSK9 (ED50 ∼0.01 mg/kg) followed by ∼2-fold increases in total PCSK9 before return to baseline. Treatment of cynomolgus monkeys with BMS-962476 rapidly suppressed free PCSK9 >99% and LDL-cholesterol ∼55% with subsequent 6-fold increase in total PCSK9, suggesting reduced clearance of circulating complex. Liver sterol response genes were consequently downregulated, following which LDL and total PCSK9 returned to baseline. These studies highlight the rapid dynamics of PCSK9 control over LDL and liver cholesterol metabolism and characterize BMS-962476 as a potent and efficacious PCSK9 inhibitor. Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics.

Measurement of a density profile of a hot-electron plasma in RT-1 with three-chord interferometry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saitoh, H.; Yano, Y.; Yoshida, Z.

2015-02-15

The electron density profile of a plasma in a magnetospheric dipole field configuration was measured with a multi-chord interferometry including a relativistic correction. In order to improve the accuracy of density reconstruction, a 75 GHz interferometer was installed at a vertical chord of the Ring Trap 1 (RT-1) device in addition to previously installed ones at tangential and another vertical chords. The density profile was calculated by using the data of three-chord interferometry including relativistic effects for a plasma consisting of hot and cold electrons generated by electron cyclotron resonance heating (ECH). The results clearly showed the effects of density peakingmore » and magnetic mirror trapping in a strongly inhomogeneous dipole magnetic field.« less

Vertical Profiles of Aerosol Volume from High Spectral Resolution Infrared Transmission Measurements: Results

NASA Technical Reports Server (NTRS)

Eldering, Annmarie; Kahn, Brian H.; Mills, Franklin P.; Irion, Fredrick W.; Steele, Helen M.; Gunson, Michael R.

2004-01-01

The high-resolution infrared absorption spectra of the Atmospheric Trace Molecule Spectroscopy (ATMOS) experiment are utilized to derive vertical profiles of sulfate aerosol volume density and extinction coefficient. Following the eruption of Mt. Pinatubo in June 1991, the ATMOS spectra obtained on three Space Shuttle missions (1992, 1993, and 1994) provide a unique opportunity to study the global stratospheric sulfate aerosol layer shortly after a major volcanic eruption and periodically during the decay phase. Synthetic sulfate aerosol spectra are fit to the observed spectra, and a global fitting inversion routine is used to derive vertical profiles of sulfate aerosol volume density. Vertical profiles of sulfate aerosol volume density for the three missions over portions of the globe are presented, with the peak in aerosol volume density occurring from as low as 10 km (polar latitudes) to as high as 20 km (subtropical latitudes). Derived aerosol volume density is as high as 2-3.5 (mu)m(exp 3) per cubic centimeter +/-10% in 1992, decreasing to 0.2-0.5 (mu)m(exp 3) per cubic centimeter +/-20% in 1994, in agreement with other experiments. Vertical extinction profiles derived from ATMOS are compared with profiles from Improved Stratospheric And Mesospheric Sounder (ISAMS) and Cryogenic Limb Array Etalon Spectrometer (CLAES) that coincide in space and time and show good general agreement. The uncertainty of the ATMOS vertical profiles is similar to CLAES and consistently smaller than ISAMS at similar altitudes.

The Halo Boundary of Galaxy Clusters in the SDSS

NASA Astrophysics Data System (ADS)

Baxter, Eric; Chang, Chihway; Jain, Bhuvnesh; Adhikari, Susmita; Dalal, Neal; Kravtsov, Andrey; More, Surhud; Rozo, Eduardo; Rykoff, Eli; Sheth, Ravi K.

2017-05-01

Analytical models and simulations predict a rapid decline in the halo density profile associated with the transition from the “infalling” regime outside the halo to the “collapsed” regime within the halo. Using data from SDSS, we explore evidence for such a feature in the density profiles of galaxy clusters using several different approaches. We first estimate the steepening of the outer galaxy density profile around clusters, finding evidence for truncation of the halo profile. Next, we measure the galaxy density profile around clusters using two sets of galaxies selected on color. We find evidence of an abrupt change in galaxy colors that coincides with the location of the steepening of the density profile. Since galaxies that have completed orbits within the cluster are more likely to be quenched of star formation and thus appear redder, this abrupt change in galaxy color can be associated with the transition from single-stream to multi-stream regimes. We also use a standard model comparison approach to measure evidence for a “splashback”-like feature, but find that this approach is very sensitive to modeling assumptions. Finally, we perform measurements using an independent cluster catalog to test for potential systematic errors associated with cluster selection. We identify several avenues for future work: improved understanding of the small-scale galaxy profile, lensing measurements, identification of proxies for the halo accretion rate, and other tests. With upcoming data from the DES, KiDS, and HSC surveys, we can expect significant improvements in the study of halo boundaries.

Effects of high-intensity training on cardiovascular risk factors in premenopausal and postmenopausal women.

PubMed

Mandrup, Camilla M; Egelund, Jon; Nyberg, Michael; Lundberg Slingsby, Martina H; Andersen, Caroline B; Løgstrup, Sofie; Bangsbo, Jens; Suetta, Charlotte; Stallknecht, Bente; Hellsten, Ylva

2017-04-01

Menopause is associated with increased risk of cardiovascular disease and the causal factors have been proposed to be the loss of estrogen and the subsequent alterations of the hormonal milieu. However, which factors contribute to the deterioration of cardiometabolic health in postmenopausal women is debated as the menopausal transition is also associated with increased age and fat mass. Furthermore, indications of reduced cardiometabolic adaptations to exercise in postmenopausal women add to the adverse health profile. We sought to evaluate risk factors for type 2 diabetes and cardiovascular disease in late premenopausal and early postmenopausal women, matched by age and body composition, and investigate the effect of high-intensity training. A 3-month high-intensity aerobic training intervention, involving healthy, nonobese, late premenopausal (n = 40) and early postmenopausal (n = 39) women was conducted and anthropometrics, body composition, blood pressure, lipid profile, glucose tolerance, and maximal oxygen consumption were determined at baseline and after the intervention. At baseline, the groups matched in anthropometrics and body composition, and only differed by 4.2 years in age (mean [95% confidence limits] 49.2 [48.5-49.9] vs 53.4 [52.4-54.4] years). Time since last menstrual period for the postmenopausal women was (mean [95% confidence limits] 3.1 [2.6-3.7] years). Hormonal levels (estrogen, follicle stimulation hormone, luteinizing hormone) confirmed menopausal status. At baseline the postmenopausal women had higher total cholesterol (P < .001), low-density lipoprotein-cholesterol (P < .05), and high-density lipoprotein-cholesterol (P < .001) than the premenopausal women. The training intervention reduced body weight (P < .01), waist circumference (P < .01), and improved body composition by increasing lean body mass (P < .001) and decreasing fat mass (P < .001) similarly in both groups. Moreover, training resulted in lower diastolic blood pressure (P < .05), resting heart rate (P < .001), total cholesterol (P < .01), low-density lipoprotein-cholesterol (P < .01), total cholesterol/high-density lipoprotein-cholesterol index (P < .01), and improved plasma insulin concentration during the oral glucose tolerance test (P < .05) in both groups. Cardiovascular risk factors are similar in late premenopausal and early postmenopausal women, matched by age and body composition, with the exception that postmenopausal women have higher high- and low-density lipoprotein-cholesterol levels. A 3-month intervention of high-intensity aerobic training reduces risk factors for type 2 diabetes and cardiovascular disease to a similar extent in late premenopausal and early postmenopausal women. Copyright © 2016 Elsevier Inc. All rights reserved.

Interpretation of scrape-off layer profile evolution and first-wall ion flux statistics on JET using a stochastic framework based on fillamentary motion

NASA Astrophysics Data System (ADS)

Walkden, N. R.; Wynn, A.; Militello, F.; Lipschultz, B.; Matthews, G.; Guillemaut, C.; Harrison, J.; Moulton, D.; Contributors, JET

2017-08-01

This paper presents the use of a novel modelling technique based around intermittent transport due to filament motion, to interpret experimental profile and fluctuation data in the scrape-off layer (SOL) of JET during the onset and evolution of a density profile shoulder. A baseline case is established, prior to shoulder formation, and the stochastic model is shown to be capable of simultaneously matching the time averaged profile measurement as well as the PDF shape and autocorrelation function from the ion-saturation current time series at the outer wall. Aspects of the stochastic model are then varied with the aim of producing a profile shoulder with statistical measurements consistent with experiment. This is achieved through a strong localised reduction in the density sink acting on the filaments within the model. The required reduction of the density sink occurs over a highly localised region with the timescale of the density sink increased by a factor of 25. This alone is found to be insufficient to model the expansion and flattening of the shoulder region as the density increases, which requires additional changes within the stochastic model. An example is found which includes both a reduction in the density sink and filament acceleration and provides a consistent match to the experimental data as the shoulder expands, though the uniqueness of this solution can not be guaranteed. Within the context of the stochastic model, this implies that the localised reduction in the density sink can trigger shoulder formation, but additional physics is required to explain the subsequent evolution of the profile.

MHD Equilibrium with Reversed Current Density and Magnetic Islands Revisited: the Vacuum Vector Potential Calculus

NASA Astrophysics Data System (ADS)

L. Braga, F.

2013-10-01

The solution of Grad-Shafranov equation determines the stationary behavior of fusion plasma inside a tokamak. To solve the equation it is necessary to know the toroidal current density profile. Recent works show that it is possible to determine a magnetohydrodynamic (MHD) equilibrium with reversed current density (RCD) profiles that presents magnetic islands. In this work we show analytical MHD equilibrium with a RCD profile and analyze the structure of the vacuum vector potential associated with these equilibria using the virtual casing principle.

Directional power absorption in helicon plasma sources excited by a half-helix antenna

NASA Astrophysics Data System (ADS)

Afsharmanesh, Mohsen; Habibi, Morteza

2017-10-01

This paper deals with the investigation of the power absorption in helicon plasma excited through a half-helix antenna driven at 13.56 {{MHz}}. The simulations were carried out by means of a code, HELIC. They were carried out by taking into account different inhomogeneous radial density profiles and for a wide range of plasma densities, from {10}11 {{{cm}}}-3 to {10}13 {{{cm}}}-3. The magnetic field was 200, 400, 600 and 1000 {{G}}. A three-parameter function was used for generating various density profiles with different volume gradients, edge gradients and density widths. The density profile had a large effect on the efficient Trivelpiece-Gould (TG) and helicon mode excitation and antenna coupling to the plasma. The fraction of power deposition via the TG mode was extremely dependent on the plasma density near the plasma boundary. Interestingly, the obtained efficient parallel helicon wavelength was close to the anticipated value for Gaussian radial density profile. Power deposition was considerably asymmetric when the \\tfrac{n}{{B}0} ratio was more than a specific value for a determined density width. The longitudinal power absorption was symmetric at approximately {n}0={10}11 {{{cm}}}-3, irrespective of the magnetic field supposed. The asymmetry became more pronounced when the plasma density was {10}12 {{{cm}}}-3. The ratio of density width to the magnetic field was an important parameter in the power coupling. At high magnetic fields, the maximum of the power absorption was reached at higher plasma density widths. There was at least one combination of the plasma density, magnetic field and density width for which the RF power deposition at both side of the tube reached its maximum value.

Effect of electrode spacing on the density distributions of electrons, ions, and metastable and radical molecules in SiH{sub 4}/NH{sub 3}/N{sub 2}/He capacitively coupled plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Ho Jun, E-mail: tiger.anima@gmail.com; Yang, Wonkyun; Joo, Junghoon

Semiconductor fabrication often requires the deposition of hydrogenated silicon nitride (SiN{sub x}H{sub y}) film using SiH{sub 4}/NH{sub 3}/N{sub 2}/He capacitively coupled plasma (CCP) discharge. As analysis of the discharge geometry is essential to understanding CCP deposition, the effect of electrode spacing on the two-dimensional distributions of electrons, ions, and metastable and radical molecules was analyzed numerically using a fluid model. The simulation shows that the spatial variations in the ionization rates near the sheath become more obvious as the electrode spacing increases. In addition, as molecule-molecule gas-phase reactions are significantly affected by the local residence time, large electrode spacings aremore » associated with significant volumetric losses for positive ions. Consequently, an increase of the electrode spacing leads axial density profiles of ions to change from bell shaped to double humped. However, NH{sub 4}{sup +} persistently maintains a bell-shaped axial density profile regardless of the degree of electrode spacing. We set the mole fraction of NH{sub 3} to only 1% of the total flow at the inlet, but NH{sub 4}{sup +} is the most abundant positive ion at the large electrode spacings. As the gas flow can transport the radicals around the space between the electrodes, we found that radical density distribution shifts toward the grounded electrode. The shift becomes pronounced as the electrode spacing increases. Finally, to validate our model, we compared the calculated deposition rate profile with the experimental data obtained along the wafer radius. According to our numerical results, the SiN{sub x}H{sub y} deposition rate decreases by approximately 16% when the electrode spacing increases from 9 to 20 mm.« less

Relation of four nontraditional lipid profiles to diabetes in rural Chinese H-type hypertension population.

PubMed

Wang, Haoyu; Guo, Xiaofan; Chen, Yintao; Li, Zhao; Xu, Jiaqi; Sun, Yingxian

2017-10-11

Mounting evidence suggested that nontraditional lipid profiles have been recognized as a reliable indicator for unfavorable cardiovascular events. The purpose of this study was to explore the role of nontraditional lipid profiles as potential clinical indices for the assessment of prevalent diabetes in rural Chinese H-type hypertension population. During 2012 to 2013, we conducted a large cross-sectional study of 2944 H-type hypertension participants (≥35 years of age) from rural areas in northeast China. Subjects underwent accurate assessment of lipid profiles, fasting plasma glucose (FPG), homocysteine (Hcy) according to standard protocols. The proportion of diabetes showed a graded and linear increase across the quartiles for all four nontraditional lipid parameters. Nontraditional lipid variables were independent determinants of FPG, and its correlation for TG/HDL-C was strongest, whether potential confounders were adjusted or not. Multivariable logistic regression analysis established that the highest triglycerides (TG)/ high-density lipoprotein cholesterol (HDL-C) quartile manifested the largest ORs of prevalent diabetes (OR: 3.275, 95%CI: 2.109-5.087) compared with the lowest quartile. The fully adjusted ORs (95%CI) were 2.753 (1.783-4.252), 2.178 (1.415-2.351), 1.648 (1.097-2.478) for the top quartile of total cholesterol (TC)/HDL-C, low-density lipoprotein cholesterol (LDL-C)/HDL-C, and non-high-density lipoprotein cholesterol (non-HDL-C), respectively. On the basis of the area under receiver-operating characteristic curve (AUC), TG/HDL-C showed the optimal discriminating power for diabetes (AUC: 0.684, 95% CI: 0.650-0.718). Nontraditional lipid profiles (TG/HDL-C, TC/HDL-C, LDL-C/HDL-C and non-HDL-C) were all consistently and independently correlated with prevalent diabetes among the H-type hypertension population in rural China. TG/HDL-C was prone to be more profitable in assessing the risk of prevalent diabetes and should be encouraged as an effective clinical tool for monitoring and targeted intervention of diabetes in H-type hypertension adults.

The signal of weak gravitational lensing from galaxy groups and clusters

NASA Astrophysics Data System (ADS)

Markert, Sean

2017-02-01

The weak gravitational lensing of galaxy clusters is a valuable tool. The deflection of light around a lens is solely dependent on the underlying distribution of foreground mass, and independent of tracers of mass such as the mass to light ratio and kinematics. As a direct probe of mass, weak lensing serves as an independent calibration of mass-observable relationships. These massive clusters are objects of great interest to astronomers, as their abundance is dependent on the conditions of the early universe, and accurate counts of clusters serve as a test of cosmological model. Upcoming surveys, such as LSST and DES, promise to push the limit of observable weak lensing, detecting clusters and sources at higher redshift than has ever been detected before. This makes accurate counts of clusters of a given mass and redshift, and proper calibration of mass-observable relationships, vital to cosmological studies. We used M> 1013.5 h-1M ⊙ halos from the MultiDark Planck simulation at z 0.5 to study the behavior of the reduced shear in clusters. We generated 2D maps of convergence and shear the halos using the GLAMER lensing library. Using these maps, we simulated observations of randomly placed background sources, and generate azimuthal averages of the shear. This reduced shear profile, and the true reduced shear profile of the halo, is fit using analytical solutions for shear of the NFW, Einasto, and truncated NFW density profile. The masses of these density profiles are then compared to the total halo masses from the halo catalogs. We find that fits to the reduced shear for halos extending past ≈ 2 h-1Mpc are fits to the noise of large scale structure along the line of sight. This noise is largely in the 45° rotated component to the reduced tangential shear, and is a breakdown in the approximation of gtan ≈ gnot required for density profile fitting of clusters. If fits are constrained to a projected radii of < 2 h-1Mpc, we see massively improved fits insensitive to the amount of structure present along the line of sight.

Microbial activity in the profiles of gray forest soil and chernozems

NASA Astrophysics Data System (ADS)

Susyan, E. A.; Rybyanets, D. S.; Ananyeva, N. D.

2006-08-01

Soil samples were taken from the profiles of a gray forest soil (under a forest) and southern chernozems of different textures under meadow vegetation. The microbial biomass (MB) was determined by the method of substrate-induced respiration; the basal respiration (BR) and the population density of microorganisms on nutrient media of different composition were also determined in the samples. The microbial metabolic quotient ( qCO2 = BR/MB) and the portion of microbial carbon (C mic) in C org were calculated. The MB and BR values were shown to decrease down the soil profiles. About 57% of the total MB in the entire soil profile was concentrated in the layer of 0-24 cm of the gray forest soil. The MB in the C horizon of chernozems was approximately two times lower than the MB in the A horizon of these soils. The correlation was found between the MB and the C org ( r = 0.99) and between the MB and the clay content ( r = 0.89) in the profile of the gray forest soil. The C mic/C org ratio in the gray forest soil and in the chernozems comprised 2.3-6.6 and 1.2-9.6%, respectively. The qCO2 value increased with the depth. The microbial community in the lower layers of the gray forest soil was dominated (88-96%) by oligotrophic microorganisms (grown on soil agar); in the upper 5 cm, these microorganisms comprised only 50% of the total amount of microorganisms grown on three media.

A Solution to ``Too Big to Fail''

NASA Astrophysics Data System (ADS)

Kohler, Susanna

2016-10-01

Its a tricky business to reconcile simulations of our galaxys formation with our current observations of the Milky Way and its satellites. In a recent study, scientists have addressed one discrepancy between simulations and observations: the so-called to big to fail problem.From Missing Satellites to Too Big to FailThe favored model of the universe is the lambda-cold-dark-matter (CDM) cosmological model. This model does a great job of correctly predicting the large-scale structure of the universe, but there are still a few problems with it on smaller scales.Hubble image of UGC 5497, a dwarf galaxy associated with Messier 81. In the missing satellite problem, simulations of galaxy formation predict that there should be more such satellite galaxies than we observe. [ESA/NASA]The first is the missing satellites problem: CDM cosmology predicts that galaxies like the Milky Way should have significantly more satellite galaxies than we observe. A proposed solution to this problem is the argument that there may exist many more satellites than weve observed, but these dwarf galaxies have had their stars stripped from them during tidal interactions which prevents us from being able to see them.This solution creates a new problem, though: the too big to fail problem. This problem states that many of the satellites predicted by CDM cosmology are simply so massive that theres no way they couldnt have visible stars. Another way of looking at it: the observed satellites of the Milky Way are not massive enough to be consistent with predictions from CDM.Artists illustration of a supernova, a type of stellar feedback that can modify the dark-matter distribution of a satellite galaxy. [NASA/CXC/M. Weiss]Density Profiles and Tidal StirringLed by Mihai Tomozeiu (University of Zurich), a team of scientists has published a study in which they propose a solution to the too big to fail problem. By running detailed cosmological zoom simulations of our galaxys formation, Tomozeiu and collaborators modeled the dark matter and the stellar content of the galaxy, tracking the formation and evolution of dark-matter subhalos.Based on the results of their simulations, the team argues that the too big to fail problem can be resolved by combining two effects:Stellar feedback in a satellite galaxy can modify its dark-matter distribution, lowering the dark-matter density in the galaxys center and creating a shallower density profile. Satellites with such shallow density profiles evolve differently than those typically modeled, which have a high concentration of dark matter in their centers.After these satellites fall into the Milky Ways potential, tidal effects such as shocks and stripping modify the mass distribution of both the dark matter and the baryons even further.Each curve represents a simulated satellites circular velocity (which corresponds to its total mass) at z=0. Left: results using typical dark-matter density profiles. Right: results using the shallower profiles expected when stellar feedback is included. Results from the shallower profiles are consistent with observed Milky-Way satellites(black crosses). [Adapted from Tomozeiu et al. 2016]A Match to ObservationsTomozeiu and collaborators found that when they used traditional density profiles to model the satellites, the satellites at z=0 in the simulation were much larger than those we observe around the Milky Way consistent with the too big to fail problem.When the team used shallower density profiles and took into account tidal effects, however, the simulations produced a distribution of satellites at z=0 that is consistent with what we observe.This study provides a tidy potential solution to the too big to fail problem, further strengthening the support for CDM cosmology.CitationMihai Tomozeiu et al 2016 ApJ 827 L15. doi:10.3847/2041-8205/827/1/L15

Adjuvant tamoxifen influences the lipid profile in breast cancer patients.

PubMed

Lin, Che; Chen, Li-Sheng; Kuo, Shou-Jen; Chen, Dar-Ren

2014-02-01

Currently there is a debate regarding whether tamoxifen used in breast cancer has an impact on lipid profiles. The aim of this study was to determine whether tamoxifen has an impact on the serum lipid profile in Taiwanese women. Data of 109 patients were collected from the routine clinical follow-up for women with hormone receptor-positive breast cancer who were treated between July 2005 and March 2008. These patients were divided into 2 subgroups, based on their tumor grade and lymph node status. Subgroup 1 patients had tumor grade I/II and a negative lymph node status. Those patients with tumor grade III or a positive lymph node status were defined as subgroup 2. In the 109 patients, the mean serum total cholesterol (TC) levels after tamoxifen treatment, as well as the serum low-density lipoprotein cholesterol (LDL-C) levels, were lower than the baseline levels, with statistically significant differences. Treatment with tamoxifen lowered the serum TC and LDL-C levels in both subgroups. The results indicate that tamoxifen has an impact on the serum lipid profile of breast cancer patients in Taiwan. Physicians should follow up the lipid profile in these patients.

Effects of low central fuelling on density and ion temperature profiles in reversed shear plasmas on JT-60U

NASA Astrophysics Data System (ADS)

Takenaga, H.; Ide, S.; Sakamoto, Y.; Fujita, T.; JT-60 Team

2008-07-01

Effects of low central fuelling on density and ion temperature profiles have been investigated using negative ion based neutral beam injection and electron cyclotron heating (ECH) in reversed shear plasmas on JT-60U. Strong internal transport barrier (ITB) was maintained in density and ion temperature profiles, when central fuelling was decreased by switching positive ion based neutral beam injection to ECH after the strong ITB formation. Similar density and ion temperature ITBs were formed for the low and high central fuelling cases during the plasma current ramp-up phase. Strong correlation between the density gradient and the ion temperature gradient was observed, indicating that particle transport and ion thermal transport are strongly coupled or the density gradient assists the ion temperature ITB formation through suppression of drift wave instabilities such as ion temperature gradient mode. These results support that the density and ion temperature ITBs can be formed under reactor relevant conditions.

Creating Hybrid Plasmas With Off-Axis ECCD for Radiating Divertor Studies in DIII-D

NASA Astrophysics Data System (ADS)

Petty, C. C.; Ferron, J. R.; Luce, T. C.; Osborne, T. H.; Petrie, T. W.; Turco, F.; Holcomb, C. T.; Thome, K. E.

2017-10-01

A long duration, high density, high power hybrid scenario has been developed for use in radiative divertor studies in DIII-D. Using 11.2 MW of co-NBI power and 3.4 MW of ECCD, with a total injected energy of up to 56 MJ, high performance hybrid plasmas with βN = 3.7 and H98y2 = 1.5 were created. The hybrid plasmas were fully non-inductive at densities of n 4.2 ×1019 m-3 with central ECCD, but the EC deposition needed to be moved to ρ = 0.45 to avoid the right-hand cutoff when the density was raised to n 5.8 ×1019 m-3 for radiative divertor studies. Although moving the EC deposition to ρ = 0.45 had the effect of dropping τE by 10%, the energy confinement time increased with higher density like τE n0.4, allowing high beta to be maintained. While the plasma current profile displays the usual self-organizing properties of hybrids - an anomalously broad profile with qmin >1 - local current drive can still have a measurable effect on stability, either positively or negatively. For example, hybrid discharges with radial ECH deposited at ρ = 0.45 proved to be more robustly stable to n = 1 modes (can be either a 1/1 or 2/1 mode) than similar discharges with co-ECCD at the same location. Interestingly, the large 1/1 mode had almost no effect on energy confinement but strongly degraded particle confinement; thus this mode needed to be suppressed to achieve the high pedestal densities required for radiative divertor studies. Work supported by USDOE under DE-FC02-04ER54698.

Baryons Matter: Why Luminous Satellite Galaxies have Reduced Central Masses

NASA Astrophysics Data System (ADS)

Zolotov, Adi; Brooks, Alyson M.; Willman, Beth; Governato, Fabio; Pontzen, Andrew; Christensen, Charlotte; Dekel, Avishai; Quinn, Tom; Shen, Sijing; Wadsley, James

2012-12-01

Using high-resolution cosmological hydrodynamical simulations of Milky Way-massed disk galaxies, we demonstrate that supernovae feedback and tidal stripping lower the central masses of bright (-15 < MV < -8) satellite galaxies. These simulations resolve high-density regions, comparable to giant molecular clouds, where stars form. This resolution allows us to adopt a prescription for H2 formation and destruction that ties star formation to the presence of shielded, molecular gas. Before infall, supernova feedback from the clumpy, bursty star formation captured by this physically motivated model leads to reduced dark matter (DM) densities and shallower inner density profiles in the massive satellite progenitors (M vir >= 109 M ⊙, M * >= 107 M ⊙) compared with DM-only simulations. The progenitors of the lower mass satellites are unable to maintain bursty star formation histories, due to both heating at reionization and gas loss from initial star-forming events, preserving the steep inner density profile predicted by DM-only simulations. After infall, gas stripping from satellites reduces the total central masses of satellites simulated with DM+baryons relative to DM-only satellites. Additionally, enhanced tidal stripping after infall due to the baryonic disk acts to further reduce the central DM densities of the luminous satellites. Satellites that enter with cored DM halos are particularly vulnerable to the tidal effects of the disk, exacerbating the discrepancy in the central masses predicted by baryon+DM and DM-only simulations. We show that DM-only simulations, which neglect the highly non-adiabatic evolution of baryons described in this work, produce denser satellites with larger central velocities. We provide a simple correction to the central DM mass predicted for satellites by DM-only simulations. We conclude that DM-only simulations should be used with great caution when interpreting kinematic observations of the Milky Way's dwarf satellites.

Lack of Association between Polymorphisms of Hepatic Lipase with Lipid Profile in Young Jordanian Adults

PubMed Central

Khabour, Omar F; Alomari, Mahmoud A; Alzoubi, Karem H; Gharaibeh, Mohammad Y; Alhashimi, Farah H

2014-01-01

The human hepatic lipase (LIPC) gene encodes hepatic lipase, an enzyme involved in lipoprotein metabolism and regulation. Therefore, variants in LIPC gene may influence plasma lipoprotein levels. In this study, the association of LIPC C-514T and G-250A polymorphisms with plasma lipid profiles in 348 young Jordanians was investigated. Genotyping of C-514T and G-250A was performed by polymerase chain reaction and subsequent digestion with DraI and NiaIII restriction enzymes, respectively, while Roche analyzer was used to determine plasma total cholesterol, triglycerides, low-and high-density lipoprotein. The G-250 and C-514 alleles were most abundant in Jordanians with 79 and 80% frequencies, respectively. Additionally, no difference was found in the lipid–lipoprotein profile between the different genotype groups of C-514T or G-250A polymorphisms, even when males and females were examined separately (P > 0.05). In young Jordanian adults, the examined LIPC polymorphisms seem to play a limited role in determining the lipid profile. PMID:25278769

Low profile thermite igniter

DOEpatents

Halcomb, Danny L.; Mohler, Jonathan H.

1991-03-05

A thermite igniter/heat source comprising a housing, high-density thermite, and low-density thermite. The housing has a relatively low profile and can focus energy by means of a torch-like ejection of hot reaction products and is externally ignitable.

Results of Detailed Modeling of the Narrow-Line Region of Seyfert Galaxies

NASA Technical Reports Server (NTRS)

Moore, David; Cohen, Ross D.

1996-01-01

We present model line profiles of [O II] lambda3727, [Ne III] lambda3869, [O I] lambda5007, [Fe VII] lambda6087, [Fe X] lambda6374, [O I] lambda6300, H(alpha) lambda6563, and [S 2] lambda6731. The profiles presented here illustrate explicitly the pronounced effects that collisional de-excitation, and that spatial variations in both the ionization parameter and cloud column density, have on Narrow-Line Region (NLR) model profiles. The above effects were included only qualitatively in a previous analytical treatment by Moore and Cohen. By making a direct correspondence between these model profiles and the analytical model profiles of Moore and Cohen, and by comparing with the observed profiles presented in a companion paper and also with those presented elsewhere in the literature, we strengthen some of the conclusions of Moore and Cohen. Most notably, we argue for constant ionization parameter, uniformly accelerated outflow of clouds that are individually stratified in ionization, and the interpretation of emission-line width correlations with ionization potential as a column density effect. For comparison with previous observational studies, such as our own in a companion paper, we also calculate profile parameters for some of the models, and we present and discuss the resulting line width correlations with critical density (n(sub cr)) and Ionization Potential (IP). Because the models we favor are those that produce extended profile wings as observed in high spectral resolution studies, the line width correlations of our favoured models are of particular interest. Line width correlations with n(sub cr) and/or IP result only if the width parameter is more sensitive to extended profile wings than is the Full Width at Half-Maximum (FWHM). Correlations between FWHM and n(sub cr) and/or IP result only after convolving the model profiles with a broad instrumental profile that simulates the lower spectral resolution used in early observational studies. The model in agreement with the greatest number of observational considerations has electron density decreasing outward from n(sub e) approx. equals 10(exp 6)/cu cm to n(sub e) approx. equals 10(exp 2)/cu cm and, due to collisional de-excitation effects in the lowest velocity clouds, it generates broad flat-topped profile peaks in the lines of lowest critical density (e.g., [O II] lambda3727 and [S II] lambda(lambda)6716, 6731). Because the observed profile peaks of both low and high critical density lines are often very similar, our favored model requires a contribution to NLR emission-line spectra from low-velocity, low-density, and low-ionization gas not included in the model NLR.

Relations for lipid bilayers. Connection of electron density profiles to other structural quantities.

PubMed Central

Nagle, J F; Wiener, M C

1989-01-01

Three relations are derived that connect low angle diffraction/scattering results obtained from lipid bilayers to other structural quantities of interest. The first relates the area along the surface of the bilayer, the measured specific volume, and the zeroth order structure factor, F(0). The second relates the size of the trough in the center of the electron density profile, the volume of the terminal methyl groups, and the volume of the methylene groups in the fatty acid chains. The third relates the size of the headgroup electron density peak, the volume of the headgroup, and the volumes of water and hydrocarbon in the headgroup region. These relations, which are easily modified for neutron diffraction, are useful for obtaining structural quantities from electron density profiles obtained by fitting model profiles to measured low angle x-ray intensities. PMID:2713444

Comment on the paper "Mars Express radio occultation data: A novel analysis approach" by Grandin et al. (2014)

NASA Astrophysics Data System (ADS)

Pätzold, M.; Bird, M. K.; Häusler, B.; Peter, K.; Tellmann, S.; Tyler, G. L.

2016-10-01

In their recent paper, Grandin et al. (2014) claim to have developed a novel approach, principally a ray tracing method, to analyze radio sounding data from occulted spacecraft signals by planetary atmospheres without the usual assumptions of the radio occultation inversion method of a stratified, layered, symmetric atmosphere. They apply their "new approach" to observations of the Mars Express Radio Science (MaRS) experiment and compare their resulting temperature, neutral number density, and electron density profiles with those from MaRS, claiming that there is good agreement with the observations. The fact is, however, that there are serious disagreements in the most important altitude ranges. Their temperature profile shows a 30 K shift or a 300σ (1σ standard deviation = 0.1 K for the MaRS profile near the surface) difference toward warmer temperatures at the surface when compared with MaRS, while the MaRS profile is in best agreement with the profile from the Mars Climate Data Base V5.0 (MCD V5.0). Their full temperature profile from the surface to 250 km altitude deviates significantly from the MCD V5.0 profile. Their ionospheric electron density profile is considerably different from that derived from the MaRs observations. Although Grandin et al. (2014) claim to derive the neutral number density and temperature profiles above 200 km, including the asymptotic exosphere temperature, it is simply not possible to derive this information from what is essentially noise.

Integrated geophysical survey in defining subsidence features on a golf course

USGS Publications Warehouse

Xia, J.; Miller, R.D.

2007-01-01

Subsidence was observed at several places on the Salina Municipal Golf Course in areas known to be built over a landfill in Salina, Kansas. High-resolution magnetic survey (???5400 m2), multi-channel electrical resistivity profiling (three 154 m lines) and microgravity profiling (23 gravity-station values) were performed on a subsidence site (Green 16) to aid in determining boundaries and density deficiency of the landfill in the vicinity of the subsidence. Horizontal boundaries of the landfill were confidently defined by both magnetic anomalies and the pseudo-vertical gradient of total field magnetic anomalies. Furthermore, the pseudo-vertical gradient of magnetic anomalies presented a unique anomaly at Green 16, which provided a criterion for predicting other spots with subsidence potential using the same gradient property. Results of multi-channel electrical resistivity profiling (ERP) suggested the bottom limit of the landfill at Green 16 was around 21 m below the ground surface based on the vertical gradient of electric resistivity and a priori information on the depth of the landfill. ERP results also outlined several possible landfill bodies based on their low resistivity values. Microgravity results suggested a -0.14 g cm-3 density deficiency at Green 16 that could equate to future surface subsidence of as much as 1.5 m due to gradual compaction. ?? 2007 Nanjing Institute of Geophysical Prospecting.

Effectiveness of chamomile tea on glycemic control and serum lipid profile in patients with type 2 diabetes.

PubMed

Rafraf, M; Zemestani, M; Asghari-Jafarabadi, M

2015-02-01

This study aimed at assessing the effects of chamomile tea consumption on glycemic control and serum lipid profile in patients with type 2 diabetes mellitus (T2DM). This single-blind randomized controlled clinical trial was conducted on 64 individuals with T2DM (males and females) aged between 30 and 60 years. The intervention group (n = 32) consumed chamomile tea (3 g/150 mL hot water) three times per day immediately after meals for 8 weeks. The control group (n = 32) followed a water regimen for the same intervention period. Fasting blood samples, anthropometric measurements, and 3-day, 24-h dietary recalls were collected at the baseline and at the end of the trial. Data were analyzed by independent t test, paired t test, Pearson correlation test, and analysis of covariance. Chamomile tea significantly decreased concentration of HbA1C (p = 0.03), serum insulin levels (p < 0.001), homeostatic model assessment for insulin resistance (p < 0.001), total cholesterol (p = 0.001), triglyceride (p < 0.001), and low-density lipoprotein cholesterol (p = 0.05) compared with control group. No significant changes were shown in serum high-density lipoprotein cholesterol levels in both groups. Chamomile tea has some beneficial effects on glycemic control and serum lipid profile in T2DM patients.

Interface Trap Profiles in 4H- and 6H-SiC MOS Capacitors with Nitrogen- and Phosphorus-Doped Gate Oxides

NASA Astrophysics Data System (ADS)

Jiao, C.; Ahyi, A. C.; Dhar, S.; Morisette, D.; Myers-Ward, R.

2017-04-01

We report results on the interface trap density ( D it) of 4H- and 6H-SiC metal-oxide-semiconductor (MOS) capacitors with different interface chemistries. In addition to pure dry oxidation, we studied interfaces formed by annealing thermal oxides in NO or POCl3. The D it profiles, determined by the C- ψ s method, show that, although the as-oxidized 4H-SiC/SiO2 interface has a much higher D it profile than 6H-SiC/SiO2, after postoxidation annealing (POA), both polytypes maintain comparable D it near the conduction band edge for the gate oxides incorporated with nitrogen or phosphorus. Unlike most conventional C- V- or G- ω-based methods, the C- ψ s method is not limited by the maximum probe frequency, therefore taking into account the "fast traps" detected in previous work on 4H-SiC. The results indicate that such fast traps exist near the band edge of 6H-SiC also. For both polytypes, we show that the total interface trap density ( N it) integrated from the C- ψ s method is several times that obtained from the high-low method. The results suggest that the detected fast traps have a detrimental effect on electron transport in metal-oxide-semiconductor field-effect transistor (MOSFET) channels.

Impact of plant-based diet on lipid risk factors for atherosclerosis.

PubMed

Kuchta, Agnieszka; Lebiedzińska, Anna; Fijałkowski, Marcin; Gałąska, Rafał; Kreft, Ewelina; Totoń, Magdalena; Czaja, Kuba; Kozłowska, Anna; Ćwiklińska, Agnieszka; Kortas-Stempak, Barbara; Strzelecki, Adrian; Gliwińska, Anna; Dąbkowski, Kamil; Jankowski, Maciej

2016-01-01

The aim of the study was to investigate the effect of a vegan diet on the serum lipid profile with particular regard to the parameters characterizing the high-density lipoprotein (HDL) fractions in subjects without subclinical atherosclerosis, measured by carotid Doppler ultrasonography. Forty-two 23 to 38 year old subjects (21 omnivores and 21 vegans) participated in the study. Compared to the omnivores, the vegan subjects were characterized by lower parameters of lipid profile: total cholesterol (p < 0.001), low-density lipoprotein (LDL)-cholesterol (p < 0.001), non-HDL-cholesterol (p < 0.001), apolipoprotein B (apoB) (p < 0.001) and phospholipids (p < 0.01). Concentration of HDL-cholesterol was apparently similar between groups. Furthermore, the parameters which characterize HDL particles (con-centration of apolipoproteins AI [apoAI] and AII, HDL-phospholipids, LpAI fraction and pre-b1-HDL fraction) were not significantly different between omnivore and vegan subjects. The apoB/apoAI ratio in vegans was lower than in omnivores (p < 0.01). There was no difference between serum concentration of triacylglycerols between omnivores and vegans. The activity of paraoxonase-1 and 8-iso-prostaglandin F2a concentration were also not different between the study groups. We suggest that a vegan diet may have a beneficial effect on serum lipid profile and cardiovascular protection, but it is not associated with changes in HDL composition.

Does Pomegranate intake attenuate cardiovascular risk factors in hemodialysis patients?

PubMed Central

2014-01-01

Background Atherosclerotic cardiovascular disease (CVD) is the most common cause of morbidity and mortality among hemodialysis (HD) patients. It has been attributed, among other causes, to hypertension and dyslipidemia. The aim of the present study was to investigate the effect of a year-long consumption of Pomegranate juice (PJ), on two traditional cardiovascular (CV) risk factors: hypertension and lipid profile, as well as on cardiovascular events. Methods 101 HD patients were randomized to receive 100 cc of PJ (0.7 mM polyphenols) or matching placebo juice, three times a week for one year. The primary endpoints were traditional CV risk factors; blood pressure and lipid profile. Systolic, diastolic and pulse pressure, plasma levels of triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and total cholesterol were monitored quarterly during the study year. Secondary endpoint was incidence of cardiovascular events. Results PJ consumption yielded a significant time response improvement in systolic blood pressure, pulse pressure, triglycerides and HDL level; an improvement that was not observed in the placebo intake group. These beneficial outcomes were more pronounced among patients with hypertension, high level of triglycerides and low levels of HDL. Conclusion Regular PJ consumption by HD patients reduced systolic blood pressure and improved lipid profile. These favorable changes may reduce the accelerated atherosclerosis and high incidence of CVD among HD patients. Trial registration ClinicalTrials.gov registry, Identifier number: NCT00727519 PMID:24593225

The Effect of Ramadan Fasting on Biochemical Parameters in Healthy Thai Subjects.

PubMed

Ongsara, Sara; Boonpol, Sakulrat; Prompalad, Nussaree; Jeenduang, Nutjaree

2017-09-01

Although, the effect of Ramadan fasting on the risks for Cardiovascular Disease (CVD) has been reported in several studies, the results were inconsistent. In addition, the effect of Ramadan fasting on biochemical parameters in Thai subjects has not been evaluated. The aim of this study was to investigate the effect of Ramadan fasting on anthropometry, blood pressure, Fasting Blood Glucose (FBG), lipid profiles, and body composition in healthy Thai subjects. A total of 65 healthy subjects (21 men and 44 women) aged between 19-24 years were randomly recruited. Anthropometry, blood pressure, FBG, Total Cholesterol (TC), Triglyceride (TG), High Density Lipoprotein-Cholesterol (HDL-C), Low Density Lipoprotein-Cholesterol (LDL-C), and body composition were measured before Ramadan, end of Ramadan and after one month of Ramadan. There were no changes in anthropometry, blood pressure, lipid profiles and body composition in both genders before Ramadan, end of Ramadan and after one month of Ramadan. Nevertheless, FBG levels were significantly increased after one month of Ramadan compared with baseline (5.09±0.50 versus 4.83±0.38 mmol/L, p=0.016, respectively) in women. The Ramadan fasting did not affect the lipid, anthropometric and body composition in healthy Thai subjects. However, the increased FBG levels after one month of Ramadan were observed in women. To improve the favourable biochemical parameters after Ramadan fasting, the lifestyle modifications such as, increased intake of healthy diets and increased physical activity should be recommended.

The Effect of Ramadan Fasting on Biochemical Parameters in Healthy Thai Subjects

PubMed Central

Ongsara, Sara; Boonpol, Sakulrat; Prompalad, Nussaree

2017-01-01

Introduction Although, the effect of Ramadan fasting on the risks for Cardiovascular Disease (CVD) has been reported in several studies, the results were inconsistent. In addition, the effect of Ramadan fasting on biochemical parameters in Thai subjects has not been evaluated. Aim The aim of this study was to investigate the effect of Ramadan fasting on anthropometry, blood pressure, Fasting Blood Glucose (FBG), lipid profiles, and body composition in healthy Thai subjects. Materials and Methods A total of 65 healthy subjects (21 men and 44 women) aged between 19-24 years were randomly recruited. Anthropometry, blood pressure, FBG, Total Cholesterol (TC), Triglyceride (TG), High Density Lipoprotein-Cholesterol (HDL-C), Low Density Lipoprotein-Cholesterol (LDL-C), and body composition were measured before Ramadan, end of Ramadan and after one month of Ramadan. Results There were no changes in anthropometry, blood pressure, lipid profiles and body composition in both genders before Ramadan, end of Ramadan and after one month of Ramadan. Nevertheless, FBG levels were significantly increased after one month of Ramadan compared with baseline (5.09±0.50 versus 4.83±0.38 mmol/L, p=0.016, respectively) in women. Conclusion The Ramadan fasting did not affect the lipid, anthropometric and body composition in healthy Thai subjects. However, the increased FBG levels after one month of Ramadan were observed in women. To improve the favourable biochemical parameters after Ramadan fasting, the lifestyle modifications such as, increased intake of healthy diets and increased physical activity should be recommended. PMID:29207694

Dietary corn fractions reduce atherogenesis in low-density lipoprotein receptor knockout mice.

PubMed

Masisi, Kabo; Le, Khuong; Ghazzawi, Nora; Moghadasian, Mohammed H; Beta, Trust

2017-01-01

Accumulating evidence has suggested that intake of whole grains is a protective factor against pathogenesis of coronary artery disease. The exact mechanisms, however, are still not clearly understood. In this study, we hypothesized that adequate intake of corn fractions (aleurone, endosperm and germ) can modify lipid profiles in relation to atherosclerotic lesion development in low-density lipoprotein receptor knockout (LDLr-KO) mice. The purpose of the present study was to investigate the potential cardiovascular benefits of corn fractions in LDLr-KO mice through a number of biomarkers including lipid profile, and morphologic and morphometrical analysis of atherosclerotic lesions in aortic root. Four groups of male LDLr-KO mice were fed with the experimental diets supplemented with (3 treated) or without (control) 5% (wt/wt) of each of corn fractions for 10 weeks. All diets were supplemented with 0.06% (wt/wt) cholesterol. Compared with mice in the control group, atherosclerotic lesions in the aortic roots were significantly reduced (P=.003) in the mice that were fed diet supplemented with aleurone and germ fractions. This effect was associated with significant reductions in plasma total (P=.02) and LDL (P=.03) cholesterol levels, and an increase in fecal cholesterol excretion (P=.04). Furthermore, abdominal fat mass was significantly reduced by consumption of aleurone (P=.03). In summary, the consumption of aleurone and germ may help attenuate atherosclerosis by reducing plasma total and LDL cholesterol levels. Copyright © 2016 Elsevier Inc. All rights reserved.

A Simultaneous Density-Integral System for Estimating Stem Profile and Biomass: Slash Pine and Willow Oak

Treesearch

Bernard R. Parresol; Charles E. Thomas

1996-01-01

In the wood utilization industry, both stem profile and biomass are important quantities. The two have traditionally been estimated separately. The introduction of a density-integral method allows for coincident estimation of stem profile and biomass, based on the calculus of mass theory, and provides an alternative to weight-ratio methodology. In the initial...

Validation of ionospheric electron density profiles inferred from GPS occultation observations of the GPS/MET experiment

NASA Astrophysics Data System (ADS)

Kawakami, Todd Mori

In April of 1995, the launch of the GPS Meteorology Experiment (GPS/MET) onboard the Orbview-1 satellite, formerly known as Microlab-1, provided the first technology demonstration of active limb sounding of the Earth's atmosphere with a low Earth orbiting spacecraft utilizing the signals transmitted by the satellites of the Global Positioning System (GPS). Though the experiment's primary mission was to probe the troposphere and stratosphere, GPS/MET was also capable of making radio occultation observations of the ionosphere. The application of the GPS occultation technique to the upper atmosphere created a unique opportunity to conduct ionospheric research with an unprecedented global distribution of observations. For operational support requirements, the Abel transform could be employed to invert the horizontal TEC profiles computed from the L1 and L2 phase measurements observed by GPS/MET into electron density profiles versus altitude in near real time. The usefulness of the method depends on how effectively the TEC limb profiles can be transformed into vertical electron density profiles. An assessment of GPS/MET's ability to determine electron density profiles needs to be examined to validate the significance of the GPS occultation method as a new and complementary ionospheric research tool to enhance the observational databases and improve space weather modeling and forecasting. To that end, simulations of the occultation observations and their inversions have been conducted to test the Abel transform algorithm and to provide qualitative information about the type and range of errors that might be experienced during the processing of real data. Comparisons of the electron density profiles inferred from real GPS/MET observations are then compared with coincident in situ measurements from the satellites of Defense Meteorological Satellite Program (DMSP) and ground-based remote sensing from digisonde and incoherent scatter radar facilities. The principal focus of this study is the validation of the electron density profiles inferred from GPS occultation observations using the Abel transform.

Mapping the dark matter in the NGC 5044 group with ROSAT: Evidence for a nearly homogeneous cooling flow with a cooling wake

NASA Technical Reports Server (NTRS)

David, Laurence P.; Jones, Christine; Forman, William; Daines, Stuart

1994-01-01

The NGC 5044 group of galaxies was observed by the ROSAT Position Sensitive Proportional Counter (PSPC) for 30 ks during its reduced pointed phase (1991 July). Due to the relatively cool gas temperature in the group (kT = 0.98 +/- 0.02 keV) and the excellent photon statistics (65,000 net counts), we are able to determine precisely a number of fundamental properties of the group within 250 kpc of the central galaxy. In particular, we present model-independent measurements of the total gravitating mass, the temperature and abundance profiles of the gas, and the mass accretion rate. Between 60 and 250 kpc, the gas is nearly isothermal with T varies as r(exp (-0.13 +/- 0.03)). The total gravitating mass of the group can be unambiguously determined from the observed density and temperature profiles of the gas using the equation of hydrostatic equilibrium. Within 250 kpc, the gravitating mass is 1.6 x 10(exp 13) solar mass, yielding a mass-to-light ratio of 130 solar mass/solar luminosity. The baryons (gas and stars) comprise 12% of the total mass within this radius. At small radii, the temperature clearly increases outward and attains a maximum value at 60 kpc. The positive temperature gradient in the center of the group confirms the existence of a cooling flow. The cooling flow region extends well beyond the temperature maximum with a cooling radius between 100 and 150 kpc. There are two distinct regions in the cooling flow separated by the temperature maximum. In the outer region, the gas is nearly isothermal with a unifor m Fe abundance of approximately 80% solar, the flow is nearly homogeneous with dot-M= 20 to 25 solar mass/year, the X-ray contours are spherically symmetric, and rho(sub gas) varies as r(exp -1.6). In the inner region, the temperature profile has a positive gradient, the mass accretion rate decreases rapidly inward, the gas density profile is steeper, and the X-ray image shows some substrucutre. NGC 5044 is offset from the centroid of the outer X-ray contours indicating that the central galaxy may have a residual velocity with respect to the center of the group potential. There is also a linear X-ray feature with an extent of approximately 30 kpc with one end coincident with NGC 5044. The X-ray emission from this feature is softer than the ambient gas. We interpret this feature as a 'cooling wake' formed by the accreting gas as it is gravitationally focused into the wake of NGC 5044. One of the most surprising results of our PSPC observation is the discovery of a nearly homogeneous cooling flow. Prior results concerning the mass accretion profile in cooling flows indicate that dot-M varies as r. This relation implies that significant mass deposition occurs at large radii which generates an inhomogeneous flow. The mass accretion rate in the NGC 5044 group is essentially a constant beyond 40 kpc (well within the cooling radius). Significant mass deposition (a declining dot-M) does not commence until the gas accretes to within 40 kpc of the group center where the radiative cooling time is approximately equals 10(exp 9) year. Th is radius also corresponds to the temperature maximum, the break in gas density profile, and the onset of structure in the X-ray image. A Hubble constant of H(sub 0) = 50 km/sec/Mpc is used throughout the paper.

Quasi-steady-state high confinement at high density by lower hybrid waves in the HT-6M tokamak

NASA Astrophysics Data System (ADS)

Li, Jiangang; Luo, Jiarong; Wan, Baonian; Wan, Yuanxi; Liu, Yuexiu; Yin, Finxian; Gong, Xianzu; Li, Duochuan; Liu, Shen; Jie, Yinxian; Gao, Xiang; Luo, Nancang; Jiang, Jiaguang; Han, Yuqing; Wu, Mingjun; Wang, Guangxin; Liang, Yunfeng; Yao, Ailing; Wu, Zhenwei; Zhang, Shouyin; Mao, Jiansan; Cui, Lingzhuo; Xu, Yuhong; Meng, Yuedong; Zhao, Junyu; Ding, Bolong; Li, Guiming; Xu, Xiangdong; Lin, Bili; Wei, Meishen; Yie, Weiwei

2000-03-01

The quasi-steady-state (tH > 10 τEoh) H mode with high plasma density (ELMy and ELM free) was routinely obtained by the injection of lower hybrid wave heating and lower hybrid current drive with a power threshold of 50 kW. The antenna spectrum was scanned over a wide range and τE was about 1.5-2.0 times that of the L mode scaling. The density increases by almost a factor of 3 during the H phase by gas puffing and the particle confinement time increases by more than this factor even with a line averaged density of 3 × 1013cm-3, which is about 60% of the Greenwald density limit. A hollow Te profile was achieved in the high density case. The experimental results reproducibly show a good agreement with the theoretical prediction for the LH off-axis power deposition profile. When a certain fraction of the plasma current is non-inductively sustained by the LH waves, a hollow current density profile is formed and the magnetic shear is reversed. This off-axis hollow profile and enhanced confinement improvement are attributed to a strong reduction of the electron thermal diffusivity in the reversed shear region.

CLASH-X: A Comparison of Lensing and X-Ray Techniques for Measuring the Mass Profiles of Galaxy Clusters

NASA Astrophysics Data System (ADS)

Donahue, Megan; Voit, G. Mark; Mahdavi, Andisheh; Umetsu, Keiichi; Ettori, Stefano; Merten, Julian; Postman, Marc; Hoffer, Aaron; Baldi, Alessandro; Coe, Dan; Czakon, Nicole; Bartelmann, Mattias; Benitez, Narciso; Bouwens, Rychard; Bradley, Larry; Broadhurst, Tom; Ford, Holland; Gastaldello, Fabio; Grillo, Claudio; Infante, Leopoldo; Jouvel, Stephanie; Koekemoer, Anton; Kelson, Daniel; Lahav, Ofer; Lemze, Doron; Medezinski, Elinor; Melchior, Peter; Meneghetti, Massimo; Molino, Alberto; Moustakas, John; Moustakas, Leonidas A.; Nonino, Mario; Rosati, Piero; Sayers, Jack; Seitz, Stella; Van der Wel, Arjen; Zheng, Wei; Zitrin, Adi

2014-10-01

We present profiles of temperature, gas mass, and hydrostatic mass estimated from new and archival X-ray observations of CLASH clusters. We compare measurements derived from XMM and Chandra observations with one another and compare both to gravitational lensing mass profiles derived with CLASH Hubble Space Telescope and Subaru Telescope lensing data. Radial profiles of Chandra and XMM measurements of electron density and enclosed gas mass are nearly identical, indicating that differences in hydrostatic masses inferred from X-ray observations arise from differences in gas-temperature measurements. Encouragingly, gas temperatures measured in clusters by XMM and Chandra are consistent with one another at ~100-200 kpc radii, but XMM temperatures systematically decline relative to Chandra temperatures at larger radii. The angular dependence of the discrepancy suggests that additional investigation on systematics such as the XMM point-spread function correction, vignetting, and off-axis responses is yet required. We present the CLASH-X mass-profile comparisons in the form of cosmology-independent and redshift-independent circular-velocity profiles. We argue that comparisons of circular-velocity profiles are the most robust way to assess mass bias. Ratios of Chandra hydrostatic equilibrium (HSE) mass profiles to CLASH lensing profiles show no obvious radial dependence in the 0.3-0.8 Mpc range. However, the mean mass biases inferred from the weak-lensing (WL) and SaWLens data are different. As an example, the weighted-mean value at 0.5 Mpc is langbrang = 0.12 for the WL comparison and langbrang = -0.11 for the SaWLens comparison. The ratios of XMM HSE mass profiles to CLASH lensing profiles show a pronounced radial dependence in the 0.3-1.0 Mpc range, with a weighted mean mass bias value rising to langbrang >~ 0.3 at ~1 Mpc for the WL comparison and langbrang ≈ 0.25 for the SaWLens comparison. The enclosed gas mass profiles from both Chandra and XMM rise to a value ≈1/8 times the total-mass profiles inferred from lensing at ≈0.5 Mpc and remain constant outside of that radius, suggesting that M gas × 8 profiles may be an excellent proxy for total-mass profiles at >~ 0.5 Mpc in massive galaxy clusters.

CLASH-X: A comparison of lensing and X-ray techniques for measuring the mass profiles of galaxy clusters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Donahue, Megan; Voit, G. Mark; Hoffer, Aaron

2014-10-20

We present profiles of temperature, gas mass, and hydrostatic mass estimated from new and archival X-ray observations of CLASH clusters. We compare measurements derived from XMM and Chandra observations with one another and compare both to gravitational lensing mass profiles derived with CLASH Hubble Space Telescope and Subaru Telescope lensing data. Radial profiles of Chandra and XMM measurements of electron density and enclosed gas mass are nearly identical, indicating that differences in hydrostatic masses inferred from X-ray observations arise from differences in gas-temperature measurements. Encouragingly, gas temperatures measured in clusters by XMM and Chandra are consistent with one another atmore » ∼100-200 kpc radii, but XMM temperatures systematically decline relative to Chandra temperatures at larger radii. The angular dependence of the discrepancy suggests that additional investigation on systematics such as the XMM point-spread function correction, vignetting, and off-axis responses is yet required. We present the CLASH-X mass-profile comparisons in the form of cosmology-independent and redshift-independent circular-velocity profiles. We argue that comparisons of circular-velocity profiles are the most robust way to assess mass bias. Ratios of Chandra hydrostatic equilibrium (HSE) mass profiles to CLASH lensing profiles show no obvious radial dependence in the 0.3-0.8 Mpc range. However, the mean mass biases inferred from the weak-lensing (WL) and SaWLens data are different. As an example, the weighted-mean value at 0.5 Mpc is (b) = 0.12 for the WL comparison and (b) = –0.11 for the SaWLens comparison. The ratios of XMM HSE mass profiles to CLASH lensing profiles show a pronounced radial dependence in the 0.3-1.0 Mpc range, with a weighted mean mass bias value rising to (b) ≳ 0.3 at ∼1 Mpc for the WL comparison and (b) ≈ 0.25 for the SaWLens comparison. The enclosed gas mass profiles from both Chandra and XMM rise to a value ≈1/8 times the total-mass profiles inferred from lensing at ≈0.5 Mpc and remain constant outside of that radius, suggesting that M {sub gas} × 8 profiles may be an excellent proxy for total-mass profiles at ≳ 0.5 Mpc in massive galaxy clusters.« less

Racial differences in levels of serum lipids and effects of exposure to persistent organic pollutants on lipid levels in residents of Anniston, Alabama.

PubMed

Aminov, Zafar; Haase, Richard; Olson, James R; Pavuk, Marian; Carpenter, David O

2014-12-01

Serum lipid levels are major risk factors for cardiovascular disease. In addition to diet, exercise, genetics, age and race, serum concentrations of persistent organic pollutants (POPs) influence concentrations of serum lipids. We investigated associations between fasting concentrations of 35 polychlorinated biphenyl (PCB) congeners and nine organochlorine pesticides in relation to total serum lipids, total cholesterol, low-density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol and triglycerides in 525 Caucasian and African American residents of Anniston, Alabama, who were not on any lipid-lowering medication. In Model 1, data were adjusted for age, age quadratic, gender, BMI, alcohol consumption, smoking and exercise, while in Model 2, additional adjustment was done for other POPs. As compared to Caucasians, African Americans had lower levels of total lipids and triglycerides with higher concentrations of HDL cholesterol, but higher concentrations of PCBs and pesticides. Total pesticides were more strongly associated with elevations in serum lipids than were total PCBs, and the associations were stronger in African Americans. Total DDTs were not associated with serum lipids after adjustment for other POPs in either racial group, while the strongest positive associations were seen for hexachlorobenzene (HCB) in both racial groups. Racial differences in lipid profiles, concentrations of POPs and associations between POP concentrations and serum lipids are relevant to racial differences in rates of cardiovascular disease. Copyright © 2014 Elsevier Ltd. All rights reserved.

Novel Phenoxazinones as potent agonist of PPAR-α: design, synthesis, molecular docking and in vivo studies.

PubMed

Ugwu, David I; Okoro, Uchechukwu C; Mishra, Narendra K; Okafor, Sunday N

2018-05-22

The use of statin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor for the treatment of dyslipidemia has been associated with dose limiting hepatoxicity, mytotoxicity and tolerability due to myalgias thereby necessitating the synthesis of new drug candidates for the treatment of lipid disorder. The reaction of appropriate benzenesulphonamide with substituted phenoxazinone in the presence of phenylboronic acid gave the targeted compounds. The molecular docking study were carried out using autodock tool against peroxisome proliferator activated receptor alpha. The in vivo lipid profile were assayed using conventional methods. The kidney and liver function test were carried out to assess the effect of the derivatives on the organs. The LD 50 of the most active derivatives were determined using mice. The targeted compounds were successfully synthesized in excellent yields and characterized using spectroscopic techniques. The results of the molecular docking experiment showed that they were good stimulant of peroxisome proliferator activated receptor alpha. Compound 9f showed activity at Ki of 2.8 nM and binding energy of 12.6 kcal/mol. All the compounds tested reduced triglyceride, total cholesterol, low density lipoprotein cholesterol and very low density lipoprotein cholesterol level in the mice model. Some of the reported compounds also increased high density lipoprotein cholesterol level in the mice. The compounds did not have appreciable effect on the kidney and liver of the mice used. The LD 50 showed that the novel compounds have improved toxicity profile. The synthesis of fifteen new derivatives of carboxamides bearing phenoxazinone and sulphonamide were successful. The compounds possessed comparable activity to gemfibrozil. The reported compounds had better toxicity profile than gemfibrozil and could serve as a replacement for the statins and fibrate class of lipid agents.

The associations between the growth hormone/insulin-like growth factor-1 axis, adiponectin, resistin and metabolic profile in children with growth hormone deficiency before and during growth hormone treatment.

PubMed

Witkowska-Sędek, Ewelina; Rumińska, Małgorzata; Stelmaszczyk-Emmel, Anna; Majcher, Anna; Pyrżak, Beata

2018-01-01

This study investigated associations between the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis, adiponectin, resistin and metabolic profile in 47 GH-deficient children before and during 12 months of GH treatment. 23 short age-matched children without growth hormone deficiency (GHD) or any genetic or chronic disorders were recruited as controls at baseline. Metabolic evaluation included measurements of adiponectin, resistin, IGF-1, total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), glucose, insulin, glycated haemoglobin (HbA1c), thyroid stimulating hormone (TSH) and free thyroxine (free T4) concentrations. The GH-deficient children had significantly higher adiponectin (p<0.05) and total cholesterol (p<0.05) levels, and a significantly lower level of resistin (p<0.05) than the controls. Resistin at 6 months of GH treatment significantly correlated with changes in height SDS in that period (r=0.35) and with the level of fasting insulin (r=0.50), the HOMA-IR (r=0.56) and the QUICKI (r=-0.53) at 12 months of therapy. Adiponectin level at 12 months of GH treatment was significantly associated with changes in HDL-C within the first 6 (r=0.73) and within 12 (r=0.56) months of therapy, while resistin significantly correlated with an increment in IGF-1 within 12 months of treatment (r=0.49) and with total-C at 12 months (r=0.56). Untreated GH-deficient children had higher adiponectin and lower resistin levels than healthy short children without GHD. Adiponectin and resistin levels did not change significantly during the first 12 months of GH therapy. Good responders to GH treatment had a tendency for higher resistin level during GH therapy, which positively correlates with the insulin resistance parameters.

Better Body Composition and Lipid Profile Can Be Associated with Vitamin D Status in Spanish Elderly? The PHYSMED Study.

PubMed

Souza, W N; Aparicio-Ugarriza, R; Bibiloni, M M; Palacios, G; Aguilar, I; Tur, J A; González-Gross, M

2017-01-01

Studies have shown that vitamin D deficiency increases the risk for lipid metabolism disorders, but this relationship has provided inconsistent results in elderly. Thus the aim was to assess the association between body composition and blood lipid profile levels on serum 25-hydrovitamin D [25(OH)D] concentration in Spanish elderly. A cross-sectional multicentre study was carried out in 383 participants (58.2% females) aged of 55-88 years. Fasting blood samples analyzed serum concentrations of 25(OH)D, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG) and total cholesterol (TC). Body composition parameters (fat mass, fat free mass) were obtained by bioimpedance, waist circumference (WC), physical activity and vitamin D intake were also evaluated. BMI, fat mass and total fat mass were lower in vitamin D sufficient subjects than vitamin D insufficient and deficient subjects, but this difference was not significant (p>0,05). Those with vitamin D adequate levels also showed lower TC/HDL ratio than those who had inadequate (insufficient or deficient) vitamin D levels (p=0.04). Significant association between 25(OH)D and BMI, waist circumference, total muscle mass, TC/HDL-c ratio, HDL and TG (for all p≤ 0.05) was found after controlling for some confounders. Subjects with inadequate HDL levels (<40mg/dL) showed 1.7 times higher odds than vitamin D deficiency than those with adequate HDL levels (>60mg/dL) (95% CI= 1.10 to 2.85 p= 0.017) and WC was negatively associated with vitamin D status odds ratio of 0.98 (0.96 to 1.00; p= 0.04). Vitamin D concentration was positively correlated with HDL-c and total muscle mass, as well as negatively correlated with WC, LDL-c/HDL-c and TC/HDL-c independently of age, gender and some confounders.

Vertical density profile and internal bond strength of wet-formed particleboard bonded with cellulose nanofibrils

Treesearch

John F. Hunt; Weiqi Leng; Mehdi Tajvidi

2017-01-01

In this study, the effects of cellulose nanofibrils (CNFs) ratio, press program, particle size, and density on the vertical density profile (VDP) and internal bond (IB) strength of the wet-formed particleboard were investigated. Results revealed that the VDP was significantly influenced by the press program. Pressing using a constant pressure (CP) press program...

Measurement of electron density profiles on HT-6M tokamak by 7-channel FIR HCN laser interferometer

NASA Astrophysics Data System (ADS)

Xiang, Gao; Qiliang, Guo

1990-12-01

Electron density measurements are periormed on HT-6M tokamak using a 7 channel Far-Infrared HCN laser interferometer. From the measured line integrals--7 channel phase shifts the electron density profile is reconstructed by a fit procedure. Results were tested by comparison to Abel inverted. Some recent interesting experimental results were reported.

Ramadan fasting ameliorates arterial pulse pressure and lipid profile, and alleviates oxidative stress in hypertensive patients.

PubMed

Al-Shafei, Ahmad I M

2014-06-01

Effects of Ramadan fasting on health are important. Its effects on arterial pulse pressure (PP), lipid profile and oxidative stress were characterized in hypertensives. PP, indices of lipid profile and oxidative stress were measured pre-, during and post-fasting in equal (40 each), sex- and age-matched groups (age 55 ± 5 years) of hypertensives (HT) and controls (C). Fasting reduced PP significantly by 17.2% and insignificantly by 9.3% in the HT and C groups, respectively. Total cholesterol (TC) was lowered insignificantly by 11.7% and 4.7% in the HT and C patients, respectively. Triglycerides (TG) and malondialdehyde (MDA) were significantly lowered by: TG: 24.5% and 22.8%; MDA: 45.6% and 54.3%; while glutathione (GSH) elevated by 56.8% and 52.6% in the HT and C groups, respectively. High-density lipoproteins (HDL) were raised significantly by 33.3% and insignificantly by 6.7%, whereas low-density lipoproteins (LDL) decreased significantly by 17.7% and insignificantly by 4.0% in the HT and C groups, respectively. At 6 weeks post-fasting, MDA remained significantly lower than the pre-fasting level by 24.3% and 25.7%, and GSH higher by 30.2% and 26.3% in the HT and C groups, respectively, while PP and TC returned to pre-fasting values in both groups. The post-fasting, HDL was significantly higher by 20.3% and LDL lower by 12.0% than the fasting levels in the HT patients. Fasting improves PP and lipids profile and ameliorates oxidative stress in hypertensives.

Cosmology and astrophysics from relaxed galaxy clusters - III. Thermodynamic profiles and scaling relations

NASA Astrophysics Data System (ADS)

Mantz, A. B.; Allen, S. W.; Morris, R. G.; Schmidt, R. W.

2016-03-01

This is the third in a series of papers studying the astrophysics and cosmology of massive, dynamically relaxed galaxy clusters. Our sample comprises 40 clusters identified as being dynamically relaxed and hot (I.e. massive) in Papers I and II of this series. Here we consider the thermodynamics of the intracluster medium, in particular the profiles of density, temperature and related quantities, as well as integrated measurements of gas mass, average temperature, total luminosity and centre-excluded luminosity. We fit power-law scaling relations of each of these quantities as a function of redshift and cluster mass, which can be measured precisely and with minimal bias for these relaxed clusters using hydrostatic arguments. For the thermodynamic profiles, we jointly model the density and temperature and their intrinsic scatter as a function of radius, thus also capturing the behaviour of the gas pressure and entropy. For the integrated quantities, we also jointly fit a multidimensional intrinsic covariance. Our results reinforce the view that simple hydrodynamical models provide a good description of relaxed clusters outside their centres, but that additional heating and cooling processes are important in the inner regions (radii r ≲ 0.5 r2500 ≈ 0.15 r500). The thermodynamic profiles remain regular, with small intrinsic scatter, down to the smallest radii where deprojection is straightforward (˜20 kpc); within this radius, even the most relaxed systems show clear departures from spherical symmetry. Our results suggest that heating and cooling are continuously regulated in a tight feedback loop, allowing the cluster atmosphere to remain stratified on these scales.

Cluster galaxy population evolution from the Subaru Hyper Suprime-Cam survey: brightest cluster galaxies, stellar mass distribution, and active galaxies

NASA Astrophysics Data System (ADS)

Lin, Yen-Ting; Hsieh, Bau-Ching; Lin, Sheng-Chieh; Oguri, Masamune; Chen, Kai-Feng; Tanaka, Masayuki; Chiu, I.-non; Huang, Song; Kodama, Tadayuki; Leauthaud, Alexie; More, Surhud; Nishizawa, Atsushi J.; Bundy, Kevin; Lin, Lihwai; Miyazaki, Satoshi; HSC Collaboration

2018-01-01

The unprecedented depth and area surveyed by the Subaru Strategic Program with the Hyper Suprime-Cam (HSC-SSP) have enabled us to construct and publish the largest distant cluster sample out to z~1 to date. In this exploratory study of cluster galaxy evolution from z=1 to z=0.3, we investigate the stellar mass assembly history of brightest cluster galaxies (BCGs), and evolution of stellar mass and luminosity distributions, stellar mass surface density profile, as well as the population of radio galaxies. Our analysis is the first high redshift application of the top N richest cluster selection, which is shown to allow us to trace the cluster galaxy evolution faithfully. Our stellar mass is derived from a machine-learning algorithm, which we show to be unbiased and accurate with respect to the COSMOS data. We find very mild stellar mass growth in BCGs, and no evidence for evolution in both the total stellar mass-cluster mass correlation and the shape of the stellar mass surface density profile. The clusters are found to contain more red galaxies compared to the expectations from the field, even after the differences in density between the two environments have been taken into account. We also present the first measurement of the radio luminosity distribution in clusters out to z~1.

Longitudinal gas-density profilometry for plasma-wakefield acceleration targets

NASA Astrophysics Data System (ADS)

Schaper, Lucas; Goldberg, Lars; Kleinwächter, Tobias; Schwinkendorf, Jan-Patrick; Osterhoff, Jens

2014-03-01

Precise tailoring of plasma-density profiles has been identified as one of the critical points in achieving stable and reproducible conditions in plasma wakefield accelerators. Here, the strict requirements of next generation plasma-wakefield concepts, such as hybrid-accelerators, with densities around 1017 cm-3 pose challenges to target fabrication as well as to their reliable diagnosis. To mitigate these issues we combine target simulation with fabrication and characterization. The resulting density profiles in capillaries with gas jet and multiple in- and outlets are simulated with the fluid code OpenFOAM. Satisfactory simulation results then are followed by fabrication of the desired target shapes with structures down to the 10 μm level. The detection of Raman scattered photons using lenses with large collection solid angle allows to measure the corresponding longitudinal density profiles at different number densities and allows a detection sensitivity down to the low 1017 cm-3 density range at high spatial resolution. This offers the possibility to gain insight into steep density gradients as for example in gas jets and at the plasma-to-vacuum transition.

A novel technique for real-time estimation of edge pedestal density gradients via reflectometer time delay data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zeng, L., E-mail: zeng@fusion.gat.com; Doyle, E. J.; Rhodes, T. L.

2016-11-15

A new model-based technique for fast estimation of the pedestal electron density gradient has been developed. The technique uses ordinary mode polarization profile reflectometer time delay data and does not require direct profile inversion. Because of its simple data processing, the technique can be readily implemented via a Field-Programmable Gate Array, so as to provide a real-time density gradient estimate, suitable for use in plasma control systems such as envisioned for ITER, and possibly for DIII-D and Experimental Advanced Superconducting Tokamak. The method is based on a simple edge plasma model with a linear pedestal density gradient and low scrape-off-layermore » density. By measuring reflectometer time delays for three adjacent frequencies, the pedestal density gradient can be estimated analytically via the new approach. Using existing DIII-D profile reflectometer data, the estimated density gradients obtained from the new technique are found to be in good agreement with the actual density gradients for a number of dynamic DIII-D plasma conditions.« less

On the Use of Topside RO-Derived Electron Density for Model Validation

NASA Astrophysics Data System (ADS)

Shaikh, M. M.; Nava, B.; Haralambous, H.

2018-05-01

In this work, the standard Abel inversion has been exploited as a powerful observation tool, which may be helpful to model the topside of the ionosphere and therefore to validate ionospheric models. A thorough investigation on the behavior of radio occultation (RO)-derived topside electron density (Ne(h))-profiles has therefore been performed with the main purpose to understand whether it is possible to predict the accuracy of a single RO-retrieved topside by comparing the peak density and height of the retrieved profile to the true values. As a first step, a simulation study based on the use of the NeQuick2 model has been performed to show that when the RO-derived electron density peak and height match the true peak values, the full topside Ne(h)-profile may be considered accurate. In order to validate this hypothesis with experimental data, electron density profiles obtained from four different incoherent scatter radars have therefore been considered together with co-located RO-derived Ne(h)-profiles. The evidence presented in this paper show that in all cases examined, if the incoherent scatter radar and the corresponding co-located RO profile have matching peak parameter values, their topsides are in very good agreement. The simulation results presented in this work also highlighted the importance of considering the occultation plane azimuth while inverting RO data to obtain Ne(h)-profile. In particular, they have indicated that there is a preferred range of azimuths of the occultation plane (80°-100°) for which the difference between the "true" and the RO-retrieved Ne(h)-profile in the topside is generally minimal.

What sets the central structure of dark matter haloes?

NASA Astrophysics Data System (ADS)

Ogiya, Go; Hahn, Oliver

2018-02-01

Dark matter (DM) haloes forming near the thermal cut-off scale of the density perturbations are unique, since they are the smallest objects and form through monolithic gravitational collapse, while larger haloes contrastingly have experienced mergers. While standard cold dark matter (CDM) simulations readily produce haloes that follow the universal Navarro-Frenk-White (NFW) density profile with an inner slope, ρ ∝ r-α, with α = 1, recent simulations have found that when the free-streaming cut-off expected for the CDM model is resolved, the resulting haloes follow nearly power-law density profiles of α ∼ 1.5. In this paper, we study the formation of density cusps in haloes using idealized N-body simulations of the collapse of proto-haloes. When the proto-halo profile is initially cored due to particle free-streaming at high redshift, we universally find ∼r-1.5 profiles irrespective of the proto-halo profile slope outside the core and large-scale non-spherical perturbations. Quite in contrast, when the proto-halo has a power-law profile, then we obtain profiles compatible with the NFW shape when the density slope of the proto-halo patch is shallower than a critical value, αini ∼ 0.3, while the final slope can be steeper for αini ≳ 0.3. We further demonstrate that the r-1.5 profiles are sensitive to small-scale noise, which gradually drives them towards an inner slope of -1, where they become resilient to such perturbations. We demonstrate that the r-1.5 solutions are in hydrostatic equilibrium, largely consistent with a simple analytic model, and provide arguments that angular momentum appears to determine the inner slope.

Simulation of the Plasma Density Evolution during Electron Cyclotron Resonance Heating at the T-10 Tokamak

NASA Astrophysics Data System (ADS)

Dnestrovskij, Yu. N.; Vershkov, V. A.; Danilov, A. V.; Dnestrovskij, A. Yu.; Zenin, V. N.; Lysenko, S. E.; Melnikov, A. V.; Shelukhin, D. A.; Subbotin, G. F.; Cherkasov, S. V.

2018-01-01

In ohmically heated (OH) plasma with low recycling, an improved particle confinement (IPC) mode is established during gas puffing. However, after gas puffing is switched off, this mode is retained only for about 100 ms, after which an abrupt phase transition into the low particle confinement (LPC) mode occurs in the entire plasma cross section. During such a transition, energy transport due to heat conduction does not change. The phase transition in OH plasma is similar to the effect of density pump-out from the plasma core, which occurs after electron cyclotron heating (ECH) is switched on. Analysis of the measured plasma pressure profiles in the T-10 tokamak shows that, after gas puffing in the OH mode is switched off, the plasma pressure profile in the IPC stage becomes more peaked and, after the peakedness exceeds a certain critical value, the IPC-LPC transition occurs. Similar processes are also observed during ECH. If the pressure profile is insufficiently peaked during ECH, then the density pump-out effect comes into play only after the critical peakedness of the pressure profile is reached. In the plasma core, the density and pressure profiles are close to the corresponding canonical profiles. This allows one to derive an expression for the particle flux within the canonical profile model and formulate a criterion for the IPC-LPC transition. The time evolution of the plasma density profile during phase transitions was simulated for a number of T-10 shots with ECH and high recycling. The particle transport coefficients in the IPC and LPC phases, as well as the dependences of these coefficients on the ECH power, are determined.

VEGAS-SSS. II. Comparing the globular cluster systems in NGC 3115 and NGC 1399 using VEGAS and FDS survey data. The quest for a common genetic heritage of globular cluster systems

NASA Astrophysics Data System (ADS)

Cantiello, Michele; D'Abrusco, Raffaele; Spavone, Marilena; Paolillo, Maurizio; Capaccioli, Massimo; Limatola, Luca; Grado, Aniello; Iodice, Enrica; Raimondo, Gabriella; Napolitano, Nicola; Blakeslee, John P.; Brocato, Enzo; Forbes, Duncan A.; Hilker, Michael; Mieske, Steffen; Peletier, Reynier; van de Ven, Glenn; Schipani, Pietro

2018-04-01

We analyze the globular cluster (GC) systems in two very different galaxies, NGC 3115 and NGC 1399. With the papers of this series, we aim at highlighting common and different properties in the GC systems in galaxies covering a wide range of parameter space. We compare the GCs in NGC 3115 and NGC 1399 as derived from the analysis of one square degree u-, g-, and i-band images taken with the VST telescope as part of the VST early-type galaxy survey (VEGAS) and Fornax deep survey (FDS). We selected GC candidates using as reference the morpho-photometric and color properties of confirmed GCs. The surface density maps of GCs in NGC 3115 reveal a morphology similar to the light profile of field stars; the same is true when blue and red GCs are taken separately. The GC maps for NGC 1399 are richer in structure and confirm the existence of an intra-cluster GC component. We confirm the presence of a spatial offset in the NGC 1399 GC centroid and find that the centroid of the GCs for NGC 3115 coincides well with the galaxy center. Both GC systems show unambiguous color bimodality in (g - i) and (u - i); the color-color relations of the two GC systems are slightly different with NGC 3115 appearing more linear than NGC 1399. The azimuthal average of the radial density profiles in both galaxies reveals a larger spatial extent for the total GCs population with respect to the galaxy surface brightness profile. For both galaxies, the red GCs have radial density profiles compatible with the galaxy light profile, while the radial profiles for blue GCs are shallower. As for the specific frequency of GCs, SN, we find it is a factor of two higher in NGC 1399 than for NGC 3115; this is mainly the result of extra blue GCs. By inspecting the radial behavior of the specific frequency, SN(

The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers.

PubMed

Bin Sayeed, Muhammad Shahdaat; Asaduzzaman, Md; Morshed, Helal; Hossain, Md Monir; Kadir, Mohammad Fahim; Rahman, Md Rezowanur

2013-07-30

Experimental evidences have demonstrated that Nigella sativa Linn. seed (NS) has positive modulation effects on aged rats with memory impairments, prevents against hippocampal pyramidal cell loss and enhances consolidation of recall capability of stored information and spatial memory in rats. NS has neuroprotective, nephroprotective, lung protective, cardioprotective, hepatoprotective activities as established by previous studies on animals. Several clinical trials with NS on human have also demonstrated beneficial effect. The present study was designed to investigate the effects of NS on memory, attention and cognition in healthy elderly volunteers. Furthermore, safety profile of NS was assessed during the nine-week study period. Forty elderly volunteers were recruited and divided randomly into group A and group B--each consisting of 20 volunteers. The treatment procedure for group A was 500 mg NS capsule twice daily for nine weeks and Group B received placebo instead of NS in the similar manner. All the volunteers were assessed for neuropsychological state and safety profile twice before treatment and after nine weeks. The neuropsychological tests were logical memory test, digit span test, Rey-Osterrieth complex figure test, letter cancellation test, trail making test and stroop test. Safety profile was assessed by measuring biochemical markers of Cardiac (total cholesterol, triglycerides and high density lipoprotein cholesterol, very low density lipoprotein, low density lipoprotein cholesterol, creatine kinase-MB); Liver (aspartate aminotransferase, alanin aminotransferase, alkaline phosphatase, total protein, albumin, bilirubin) and Kidney (creatinine and blood urea nitrogen) through using commercial kits. There was significant difference (p<0.05) in the score of logical memory test-I and II, total score of digit span, 30 min delayed-recall, percent score in Rey-Osterrieth complex figure test, time taken to complete letter cancellation test, time taken in trail making test-A and test-B, score in part C of stroop test due to ingestion of NS for nine weeks. There were not statistically significant changes (p>0.05) in any of the biochemical markers of cardiac, liver, kidney function during this nine-week study period. The current study demonstrates the role of NS in enhancing memory, attention and cognition. Therefore, whether NS could be considered as potential food supplement for preventing or slow progressing of Alzheimer disease needs further investigations. However, study with Alzheimer's patients with large population size for longer period of time is recommended before using NS daily and extensive phytochemical investigations are recommended for novel drug discovery from NS for treating cognitive disorders. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Effects of Dietary Lycopene Supplementation on Plasma Lipid Profile, Lipid Peroxidation and Antioxidant Defense System in Feedlot Bamei Lamb.

PubMed

Jiang, Hongqin; Wang, Zhenzhen; Ma, Yong; Qu, Yanghua; Lu, Xiaonan; Luo, Hailing

2015-07-01

Lycopene, a red non-provitamin A carotenoid, mainly presenting in tomato and tomato byproducts, has the highest antioxidant activity among carotenoids because of its high number of conjugated double bonds. The objective of this study was to investigate the effect of lycopene supplementation in the diet on plasma lipid profile, lipid peroxidation and antioxidant defense system in feedlot lamb. Twenty-eight Bamei male lambs (90 days old) were divided into four groups and fed a basal diet (LP0, 40:60 roughage: concentrate) or the basal diet supplemented with 50, 100, and 200 mg/kg lycopene. After 120 days of feeding, all lambs were slaughtered and sampled. Dietary lycopene supplementation significantly reduced the levels of plasma total cholesterol (p<0.05, linearly), total triglycerides (TG, p<0.05) and low-density lipoprotein cholesterol (LDL-C, p<0.05), as well as atherogenic index (p<0.001), whereas no change was observed in high-density lipoprotein cholesterol (p>0.05). The levels of TG (p<0.001) and LDL-C (p<0.001) were decreased with the feeding time extension, and both showed a linear trend (p<0.01). Malondialdehyde level in plasma and liver decreased linearly with the increase of lycopene inclusion levels (p<0.01). Dietary lycopene intake linearly increased the plasma antioxidant vitamin E level (p<0.001), total antioxidant capacity (T-AOC, p<0.05), and activities of catalase (CAT, p<0.01), glutathione peroxidase (GSH-Px, p<0.05) and superoxide dismutase (SOD, p<0.05). The plasma T-AOC and activities of GSH-Px and SOD decreased with the extension of the feeding time. In liver, dietary lycopene inclusion showed similar antioxidant effects with respect to activities of CAT (p<0.05, linearly) and SOD (p<0.001, linearly). Therefore, it was concluded that lycopene supplementation improved the antioxidant status of the lamb and optimized the plasma lipid profile, the dosage of 200 mg lycopene/kg feed might be desirable for growing lambs to prevent environment stress and maintain normal physiological metabolism.

Density profiles of supernova matter and determination of neutrino parameters

NASA Astrophysics Data System (ADS)

Chiu, Shao-Hsuan

2007-08-01

The flavor conversion of supernova neutrinos can lead to observable signatures related to the unknown neutrino parameters. As one of the determinants in dictating the efficiency of resonant flavor conversion, the local density profile near the Mikheyev-Smirnov-Wolfenstein (MSW) resonance in a supernova environment is, however, not so well understood. In this analysis, variable power-law functions are adopted to represent the independent local density profiles near the locations of resonance. It is shown that the uncertain matter density profile in a supernova, the possible neutrino mass hierarchies, and the undetermined 1-3 mixing angle would result in six distinct scenarios in terms of the survival probabilities of νe and ν¯e. The feasibility of probing the undetermined neutrino mass hierarchy and the 1-3 mixing angle with the supernova neutrinos is then examined using several proposed experimental observables. Given the incomplete knowledge of the supernova matter profile, the analysis is further expanded to incorporate the Earth matter effect. The possible impact due to the choice of models, which differ in the average energy and in the luminosity of neutrinos, is also addressed in the analysis.

Compton profiles and electronic properties of TiB{sub 2}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhatt, Samir, E-mail: sameerbhatt011@gmail.com; Suthar, K. K.; Ahuja, B. L.

In this paper, we report the experimental Compton profile (CP) of TiB{sub 2} using high energy {sup 137}Cs γ-rays Compton spectrometer. To interpret the experimental momentum density, we have calculated the CPs using Hartree-Fock (HF), density functional theory (DFT) and hybridization of DFT and HF within linear combination of atomic orbitals. The theoretical profile with generalized gradient approximation is found to be relatively in better agreement with the experimental profile. A sharp valley in density of states and hence the pseudogap near the Fermi energy is attributed to hybridization of Ti-3d and B-2p states and almost reverse trend of energymore » bands below and above the Fermi energy.« less

[Pathogenic mechanisms of proatherogenic changes in pregnant women with concomitant obesity].

PubMed

Tarasenko, K V; Mamontova, T V

2013-12-01

The concentration of insulin, high sensitivity C-reactive protein (CRP) and indices of lipid metabolism (concentrations of triacylglycerols, total cholesterol, cholesterol of low density lipoproteins and cholesterol of very low density lipoproteins) in women with concomitant obesity in the second trimester of pregnancy were studied. Changes of the lipid profile in the pregnant women with concomitant obesity indicate development of type IV hyperlipoproteinemia. Concentrations of insulin and CRP in the blood serum of the pregnant women with obesity were respectively 92.1% and 62.5% higher than in the control group. On the basis of literature data and our own research it was concluded that the complex of the metabolic changes (insulin resistance, dislipidemia, endothelial dysfunction, systemic inflammation) in pregnant women with obesity promotes development of proatherogenic changes.

Monte Carlo study of one-dimensional confined fluids with Gay-Berne intermolecular potential

NASA Astrophysics Data System (ADS)

Moradi, M.; Hashemi, S.

2011-11-01

The thermodynamic quantities of a one dimensional system of particles with Gay-Berne model potential confined between walls have been obtained by means of Monte Carlo computer simulations. For a number of temperatures, the systems were considered and their density profiles, order parameter, pressure, configurational temperature and average potential energy per particle are reported. The results show that by decreasing the temperature, the soft particles become more ordered and they align to the walls and also they don't show any tendency to be near the walls at very low temperatures. We have also changed the structure of the walls by embedding soft ellipses in them, this change increases the total density near the wall whereas, increasing or decreasing the order parameter depend on the angle of embedded ellipses.

Discharge Characterization of 40 cm-Microwave ECR Ion Source and Neutralizer

NASA Technical Reports Server (NTRS)

Foster, John E.; Patterson, Michael J.; Britton, Melissa

2003-01-01

Discharge characteristics of a 40 cm, 2.45 GHz Electron Cyclotron Resonance (ECR) ion thruster discharge chamber and neutralizer were acquired. Thruster bulk discharge plasma characteristics were assessed using a single Langmuir probe. Total extractable ion current was measured as a function of input microwave power and flow rate. Additionally, radial ion current density profiles at the thruster.s exit plane were characterized using five equally spaced Faraday probes. Distinct low and high density operating modes were observed as discharge input power was varied from 0 to 200 W. In the high mode, extractable ion currents as high as 0.82 A were measured. Neutralizer emission current was characterized as a function of flow rate and microwave power. Neutralizer extraction currents as high as 0.6 A were measured.

The halo boundary of galaxy clusters in the SDSS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baxter, Eric; Chang, Chihway; Jain, Bhuvnesh

Analytical models and simulations predict a rapid decline in the halo density profile associated with the transition from the "infalling" regime outside the halo to the "collapsed" regime within the halo. Using data from SDSS, we explore evidence for such a feature in the density profiles of galaxy clusters using several different approaches. We first estimate the steepening of the outer galaxy density profile around clusters, finding evidence for truncation of the halo profile. Next, we measure the galaxy density profile around clusters using two sets of galaxies selected on color. We find evidence of an abrupt change in galaxymore » colors that coincides with the location of the steepening of the density profile. Since galaxies that have completed orbits within the cluster are more likely to be quenched of star formation and thus appear redder, this abrupt change in galaxy color can be associated with the transition from single-stream to multi-stream regimes. We also use a standard model comparison approach to measure evidence for a "splashback"-like feature, but find that this approach is very sensitive to modeling assumptions. Finally, we perform measurements using an independent cluster catalog to test for potential systematic errors associated with cluster selection. We identify several avenues for future work: improved understanding of the small-scale galaxy profile, lensing measurements, identification of proxies for the halo accretion rate, and other tests. As a result, with upcoming data from the DES, KiDS, and HSC surveys, we can expect significant improvements in the study of halo boundaries.« less

The Halo Boundary of Galaxy Clusters in the SDSS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baxter, Eric; Jain, Bhuvnesh; Sheth, Ravi K.

Analytical models and simulations predict a rapid decline in the halo density profile associated with the transition from the “infalling” regime outside the halo to the “collapsed” regime within the halo. Using data from SDSS, we explore evidence for such a feature in the density profiles of galaxy clusters using several different approaches. We first estimate the steepening of the outer galaxy density profile around clusters, finding evidence for truncation of the halo profile. Next, we measure the galaxy density profile around clusters using two sets of galaxies selected on color. We find evidence of an abrupt change in galaxymore » colors that coincides with the location of the steepening of the density profile. Since galaxies that have completed orbits within the cluster are more likely to be quenched of star formation and thus appear redder, this abrupt change in galaxy color can be associated with the transition from single-stream to multi-stream regimes. We also use a standard model comparison approach to measure evidence for a “splashback”-like feature, but find that this approach is very sensitive to modeling assumptions. Finally, we perform measurements using an independent cluster catalog to test for potential systematic errors associated with cluster selection. We identify several avenues for future work: improved understanding of the small-scale galaxy profile, lensing measurements, identification of proxies for the halo accretion rate, and other tests. With upcoming data from the DES, KiDS, and HSC surveys, we can expect significant improvements in the study of halo boundaries.« less

The halo boundary of galaxy clusters in the SDSS

DOE PAGES

Baxter, Eric; Chang, Chihway; Jain, Bhuvnesh; ...

2017-05-18

Analytical models and simulations predict a rapid decline in the halo density profile associated with the transition from the "infalling" regime outside the halo to the "collapsed" regime within the halo. Using data from SDSS, we explore evidence for such a feature in the density profiles of galaxy clusters using several different approaches. We first estimate the steepening of the outer galaxy density profile around clusters, finding evidence for truncation of the halo profile. Next, we measure the galaxy density profile around clusters using two sets of galaxies selected on color. We find evidence of an abrupt change in galaxymore » colors that coincides with the location of the steepening of the density profile. Since galaxies that have completed orbits within the cluster are more likely to be quenched of star formation and thus appear redder, this abrupt change in galaxy color can be associated with the transition from single-stream to multi-stream regimes. We also use a standard model comparison approach to measure evidence for a "splashback"-like feature, but find that this approach is very sensitive to modeling assumptions. Finally, we perform measurements using an independent cluster catalog to test for potential systematic errors associated with cluster selection. We identify several avenues for future work: improved understanding of the small-scale galaxy profile, lensing measurements, identification of proxies for the halo accretion rate, and other tests. As a result, with upcoming data from the DES, KiDS, and HSC surveys, we can expect significant improvements in the study of halo boundaries.« less

Migration of fallout radiocaesium in a grassland soil from 1986 to 2001. Part I: activity-depth profiles of (134)Cs and (137)Cs.

PubMed

Schimmack, W; Schultz, W

2006-09-15

The temporal changes of the vertical distribution of (134)Cs (deposited by the Chernobyl fallout in 1986) and (137)Cs (deposited by the Chernobyl and the global fallout) in the soil were investigated at an undisturbed Bavarian grassland site in Germany. At ten sampling dates between 1986 and 2001, the activity density of (134)Cs and (137)Cs was determined in various soil layers down to 80 cm depth. In 2001, the small-scale spatial variability of the radiocaesium activity was determined by sampling five plots within 10 m(2) (coefficient of variation about 20% for the upper soil layers). Between 1987 and 1990, substantial changes of the activity-depth profiles were observed. The percentage depth distributions of (134)Cs and (137)Cs were rather similar. The 50%-depth of the accumulated activity increased from 2.4 cm in 1988 to 5.3 cm in 2001 for (134)Cs and from 2.7 to 5.8 cm for (137)Cs. This indicates that at the study site the migration data of Chernobyl-derived (137)Cs can be estimated by those of total (137)Cs. In the second part of this study, the activity-depth profiles will be evaluated by the convection-dispersion model [Schimmack, W, Feria Márquez, F. Migration of fallout radiocaesium in a grassland soil from 1986 to 2001. Part II: Evaluation of the activity-depth profiles by transport models. Sci Total Environ 2006-this issue].

galstep: Initial conditions for spiral galaxy simulations

NASA Astrophysics Data System (ADS)

Ruggiero, Rafael

2017-11-01

galstep generates initial conditions for disk galaxy simulations with GADGET-2 (ascl:0003.001), RAMSES (ascl:1011.007) and GIZMO (ascl:1410.003), including a stellar disk, a gaseous disk, a dark matter halo and a stellar bulge. The first two components follow an exponential density profile, and the last two a Dehnen density profile with gamma=1 by default, corresponding to a Hernquist profile.

Low profile thermite igniter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Halcomb, D.L.; Mohler, J.H.

1991-03-05

This patent describes a thermite igniter/heat source comprising a housing, high-density thermite, and low-density thermite. The housing has a relatively low profile and can focus energy by means of a torch-like ejection of hot reaction products and is externally ignitable.

The diverse density profiles of galaxy clusters with self-interacting dark matter plus baryons

NASA Astrophysics Data System (ADS)

Robertson, Andrew; Massey, Richard; Eke, Vincent; Tulin, Sean; Yu, Hai-Bo; Bahé, Yannick; Barnes, David J.; Bower, Richard G.; Crain, Robert A.; Dalla Vecchia, Claudio; Kay, Scott T.; Schaller, Matthieu; Schaye, Joop

2018-05-01

We present the first simulated galaxy clusters (M200 > 1014 M⊙) with both self-interacting dark matter (SIDM) and baryonic physics. They exhibit a greater diversity in both dark matter and stellar density profiles than their counterparts in simulations with collisionless dark matter (CDM), which is generated by the complex interplay between dark matter self-interactions and baryonic physics. Despite variations in formation history, we demonstrate that analytical Jeans modelling predicts the SIDM density profiles remarkably well, and the diverse properties of the haloes can be understood in terms of their different final baryon distributions.

Methodology for extraction of space charge density profiles at nanoscale from Kelvin probe force microscopy measurements.

PubMed

Villeneuve-Faure, C; Boudou, L; Makasheva, K; Teyssedre, G

2017-12-15

To understand the physical phenomena occurring at metal/dielectric interfaces, determination of the charge density profile at nanoscale is crucial. To deal with this issue, charges were injected applying a DC voltage on lateral Al-electrodes embedded in a SiN x thin dielectric layer. The surface potential induced by the injected charges was probed by Kelvin probe force microscopy (KPFM). It was found that the KPFM frequency mode is a better adapted method to probe accurately the charge profile. To extract the charge density profile from the surface potential two numerical approaches based on the solution to Poisson's equation for electrostatics were investigated: the second derivative model method, already reported in the literature, and a new 2D method based on the finite element method (FEM). Results highlight that the FEM is more robust to noise or artifacts in the case of a non-flat initial surface potential. Moreover, according to theoretical study the FEM appears to be a good candidate for determining charge density in dielectric films with thicknesses in the range from 10 nm to 10 μm. By applying this method, the charge density profile was determined at nanoscale, highlighting that the charge cloud remains close to the interface.

Novel analysis technique for measuring edge density fluctuation profiles with reflectometry in the Large Helical Device.

PubMed

Creely, A J; Ida, K; Yoshinuma, M; Tokuzawa, T; Tsujimura, T; Akiyama, T; Sakamoto, R; Emoto, M; Tanaka, K; Michael, C A

2017-07-01

A new method for measuring density fluctuation profiles near the edge of plasmas in the Large Helical Device (LHD) has been developed utilizing reflectometry combined with pellet-induced fast density scans. Reflectometer cutoff location was calculated by proportionally scaling the cutoff location calculated with fast far infrared laser interferometer (FIR) density profiles to match the slower time resolution results of the ray-tracing code LHD-GAUSS. Plasma velocity profile peaks generated with this reflectometer mapping were checked against velocity measurements made with charge exchange spectroscopy (CXS) and were found to agree within experimental uncertainty once diagnostic differences were accounted for. Measured density fluctuation profiles were found to peak strongly near the edge of the plasma, as is the case in most tokamaks. These measurements can be used in the future to inform inversion methods of phase contrast imaging (PCI) measurements. This result was confirmed with both a fixed frequency reflectometer and calibrated data from a multi-frequency comb reflectometer, and this method was applied successfully to a series of discharges. The full width at half maximum of the turbulence layer near the edge of the plasma was found to be only 1.5-3 cm on a series of LHD discharges, less than 5% of the normalized minor radius.

Development of Long-Pulse Heating and Current Drive Actuators and Operational Techniques Compatible with a High-Z Divertor and First Wall

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Guiding

Accurate measurement of the edge electron density profile is essential to optimizing antenna coupling and assessment of impurity contamination in studying long-pulse plasma heating and current drive in fusion devices. Measurement of the edge density profile has been demonstrated on the US fusion devices such as C-Mod, DIII-D, and TFTR amongst many devices, and has been used for RF loading and impurity modeling calculations for many years. University of Science and Technology of China (USTC) has recently installed a density profile reflectometer system on the EAST fusion device at the Institute of Plasma Physics, Chinese Academy of Sciences in Chinamore » based on the University of California Los Angeles (UCLA)-designed reflectometer system on the DIII-D fusion device at General Atomics Company in San Diego, California. UCLA has been working with USTC to optimize the existing microwave antenna, waveguide system, microwave electronics, and data analysis to produce reliable edge density profiles. During the past budget year, progress has been made in all three major areas: effort to achieve reliable system operations under various EAST operational conditions, effort to optimize system performance, and effort to provide quality density profiles into EAST’s database routinely.« less

Novel analysis technique for measuring edge density fluctuation profiles with reflectometry in the Large Helical Device

NASA Astrophysics Data System (ADS)

Creely, A. J.; Ida, K.; Yoshinuma, M.; Tokuzawa, T.; Tsujimura, T.; Akiyama, T.; Sakamoto, R.; Emoto, M.; Tanaka, K.; Michael, C. A.

2017-07-01

A new method for measuring density fluctuation profiles near the edge of plasmas in the Large Helical Device (LHD) has been developed utilizing reflectometry combined with pellet-induced fast density scans. Reflectometer cutoff location was calculated by proportionally scaling the cutoff location calculated with fast far infrared laser interferometer (FIR) density profiles to match the slower time resolution results of the ray-tracing code LHD-GAUSS. Plasma velocity profile peaks generated with this reflectometer mapping were checked against velocity measurements made with charge exchange spectroscopy (CXS) and were found to agree within experimental uncertainty once diagnostic differences were accounted for. Measured density fluctuation profiles were found to peak strongly near the edge of the plasma, as is the case in most tokamaks. These measurements can be used in the future to inform inversion methods of phase contrast imaging (PCI) measurements. This result was confirmed with both a fixed frequency reflectometer and calibrated data from a multi-frequency comb reflectometer, and this method was applied successfully to a series of discharges. The full width at half maximum of the turbulence layer near the edge of the plasma was found to be only 1.5-3 cm on a series of LHD discharges, less than 5% of the normalized minor radius.

Role of ion magnetization in formation of radial density profile in magnetically expanding plasma produced by helicon antenna

NASA Astrophysics Data System (ADS)

Yadav, Sonu; Ghosh, Soumen; Bose, Sayak; Barada, Kshitish K.; Pal, Rabindranath; Chattopadhyay, Prabal K.

2018-04-01

Experimentally, the density profile in the magnetic nozzle of a helicon antenna based plasma device is seen to be modified from being centrally peaked to that of hollow nature as the external magnetic field is increased. It occurs above a characteristic field value when the ions become magnetized in the expansion chamber. The density profile in the source chamber behind the nozzle, however, remains peaked on-axis irrespective of the magnetic field. The electron temperature there is observed to be hollow and this nature is carried to the expansion chamber along the field line. In the electron energy distribution near the off axis peak location, a high energy tail exists. Rotation of these tail electrons in the azimuthal direction due to the gradient-B drift in the expansion chamber leads to an additional off-axis ionization and forms the hollow density profile. It seems that if the ions are not magnetized, then the off-axially produced additional plasma is not confined and the density profile retains the on-axis peak nature. The present experiment successfully demonstrates how the knowledge of the ion magnetization together with tail electrons significantly contributes to the design of an efficient helicon plasma based thruster.

A field-to-desktop toolchain for X-ray CT densitometry enables tree ring analysis.

PubMed

De Mil, Tom; Vannoppen, Astrid; Beeckman, Hans; Van Acker, Joris; Van den Bulcke, Jan

2016-06-01

Disentangling tree growth requires more than ring width data only. Densitometry is considered a valuable proxy, yet laborious wood sample preparation and lack of dedicated software limit the widespread use of density profiling for tree ring analysis. An X-ray computed tomography-based toolchain of tree increment cores is presented, which results in profile data sets suitable for visual exploration as well as density-based pattern matching. Two temperate (Quercus petraea, Fagus sylvatica) and one tropical species (Terminalia superba) were used for density profiling using an X-ray computed tomography facility with custom-made sample holders and dedicated processing software. Density-based pattern matching is developed and able to detect anomalies in ring series that can be corrected via interactive software. A digital workflow allows generation of structure-corrected profiles of large sets of cores in a short time span that provide sufficient intra-annual density information for tree ring analysis. Furthermore, visual exploration of such data sets is of high value. The dated profiles can be used for high-resolution chronologies and also offer opportunities for fast screening of lesser studied tropical tree species. © The Author 2016. Published by Oxford University Press on behalf of the Annals of Botany Company. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Methodology for extraction of space charge density profiles at nanoscale from Kelvin probe force microscopy measurements

NASA Astrophysics Data System (ADS)

Villeneuve-Faure, C.; Boudou, L.; Makasheva, K.; Teyssedre, G.

2017-12-01

To understand the physical phenomena occurring at metal/dielectric interfaces, determination of the charge density profile at nanoscale is crucial. To deal with this issue, charges were injected applying a DC voltage on lateral Al-electrodes embedded in a SiN x thin dielectric layer. The surface potential induced by the injected charges was probed by Kelvin probe force microscopy (KPFM). It was found that the KPFM frequency mode is a better adapted method to probe accurately the charge profile. To extract the charge density profile from the surface potential two numerical approaches based on the solution to Poisson’s equation for electrostatics were investigated: the second derivative model method, already reported in the literature, and a new 2D method based on the finite element method (FEM). Results highlight that the FEM is more robust to noise or artifacts in the case of a non-flat initial surface potential. Moreover, according to theoretical study the FEM appears to be a good candidate for determining charge density in dielectric films with thicknesses in the range from 10 nm to 10 μm. By applying this method, the charge density profile was determined at nanoscale, highlighting that the charge cloud remains close to the interface.

The galaxy cluster outskirts probed by Chandra

NASA Astrophysics Data System (ADS)

Morandi, Andrea; Sun, Ming; Forman, William; Jones, Christine

2015-08-01

Exploring the virialization region of galaxy clusters has recently raised the attention of the scientific community, offering a direct view of structure formation. In this talk, I will present recent results on the physical properties of the intracluster medium in the outer volumes of a sample of 320 clusters (0.056 3 keV) in the Chandra archive, with a total integration time of ~20 Ms. We stacked the emission measure profiles of the clusters to detect a signal out to R_{100}. We then measured the average emission measure, gas density and gas fraction, which scale according to the self-similar model of cluster formation. We observe a steepening of the density profiles beyond R_{500} with slope beta ~ 0.68 at R_{500} and beta ~ 1 at R_{200} and beyond. By tracking the direction of the cosmic filaments where the clusters are embedded, we report that galaxy clusters deviate from spherical symmetry. We also did not find evolution of the gas density with redshift, confirming the self-similar evolution of the gas density. The value of the baryon fraction reaches the cosmic value at R_{200}: however, systematics due to non-thermal pressure support and clumpiness might enhance the measured gas fraction, leading to an actual deficit of the baryon budget with respect to the primordial value). This novel method, the stacking the X-ray signal of cluster outskirts, has the capacity to provide a generational leap forward in our understanding of cluster physics and formation, and the use of clusters as cosmological probes.

Microwave Interferometric Density Measurements of a Pulsed Helicon Source

NASA Astrophysics Data System (ADS)

Scime, Ethan; Scime, Earl; Thompson, Derek

2017-10-01

The intense rf environment of a helicon plasma source is problematic for electrostatic probe measurements of plasma density, particularly at low neutral pressures. Here we present measurements of the line-integrated plasma density in a helicon plasma source using a multi-frequency (20-40 GHz) microwave interferometer. The design of the diagnostic and the data acquisition system are presented, as well as a comparison to density profiles obtained with a moveable electrostatic probe. A parametric fit to the probe profile measurements is used to determine the peak density from the microwave density measurements. This work supported by U.S. National Science Foundation Grant No. PHY-1360278.

Variations of E-region total electron content and electron density profiles over high latitudes during winter solstice 2007 using radio occultation measurements

NASA Astrophysics Data System (ADS)

Agrawal, Kajli

The space weather phenomenon involves the Sun, interplanetary space and the Earth. Different space weather conditions have diverse effects on the various layers of the Earth's atmosphere Technological advancements have created a situation in which human civilization is not only dependent on resources from deep inside the Earth, but also on the upper atmosphere and outer space region. Therefore, it is essential to improve the understanding of the impacts of space weather conditions on the ionosphere. This research focuses on the variation of total electron content (TEC) and the electron density within the E-region of the ionosphere, which extends from 80-150 km above the surface of the Earth, using radio occultation measurements obtained by COSMIC satellites and using Ionospheric Data Assimilation Four-Dimensional algorithm (IDA4D) which is used to mitigate the effects of F-region in the E-region estimation (Bust, Garner, & Gaussiran, 2004). E-region TEC and the electron density estimation for geomagnetic latitude range of 45°--80°, geomagnetic longitude range of -180°--180° and 1800--0600 MLT (magnetic local time) are presented for two active and two quiet days during winter solstice 2007. Active and quiet days are identified based on the Kp index values. Some of the important findings are (1) E-region electron peak density is higher during active days than during quiet days, and (2) during both types of days, higher density values were found at the magnetic latitude of >60° early morning MLT. Prominent E-region features (TEC and electron density) were observed during most active days over the magnetic latitude range of 60°-70° at ~02:00 MLT.

Effects of an Encapsulated Fruit and Vegetable Juice Concentrate on Obesity-Induced Systemic Inflammation: A Randomised Controlled Trial

PubMed Central

Williams, Evan J.; Baines, Katherine J.; Berthon, Bronwyn S.; Wood, Lisa G.

2017-01-01

Phytochemicals from fruit and vegetables reduce systemic inflammation. This study examined the effects of an encapsulated fruit and vegetable (F&V) juice concentrate on systemic inflammation and other risk factors for chronic disease in overweight and obese adults. A double-blinded, parallel, randomized placebo-controlled trial was conducted in 56 adults aged ≥40 years with a body mass index (BMI) ≥28 kg/m2. Before and after eight weeks daily treatment with six capsules of F&V juice concentrate or placebo, peripheral blood gene expression (microarray, quantitative polymerase chain reaction (qPCR)), plasma tumour necrosis factor (TNF)α (enzyme-linked immunosorbent assay (ELISA)), body composition (Dual-energy X-ray absorptiometry (DEXA)) and lipid profiles were assessed. Following consumption of juice concentrate, total cholesterol, low-density lipoprotein (LDL) cholesterol and plasma TNFα decreased and total lean mass increased, while there was no change in the placebo group. In subjects with high systemic inflammation at baseline (serum C-reactive protein (CRP) ≥3.0 mg/mL) who were supplemented with the F&V juice concentrate (n = 16), these effects were greater, with decreased total cholesterol, LDL cholesterol and plasma TNFα and increased total lean mass; plasma CRP was unchanged by the F&V juice concentrate following both analyses. The expression of several genes involved in lipogenesis, the nuclear factor-κB (NF-κB) and 5′ adenosine monophosphate-activated protein kinase (AMPK) signalling pathways was altered, including phosphomevalonate kinase (PMVK), zinc finger AN1-type containing 5 (ZFAND5) and calcium binding protein 39 (CAB39), respectively. Therefore, F&V juice concentrate improves the metabolic profile, by reducing systemic inflammation and blood lipid profiles and, thus, may be useful in reducing the risk of obesity-induced chronic disease. PMID:28208713

Real-Gas Effects on Binary Mixing Layers

NASA Technical Reports Server (NTRS)

Okong'o, Nora; Bellan, Josette

2003-01-01

This paper presents a computational study of real-gas effects on the mean flow and temporal stability of heptane/nitrogen and oxygen/hydrogen mixing layers at supercritical pressures. These layers consist of two counterflowing free streams of different composition, temperature, and density. As in related prior studies reported in NASA Tech Briefs, the governing conservation equations were the Navier-Stokes equations of compressible flow plus equations for the conservation of total energy and of chemical- species masses. In these equations, the expressions for heat fluxes and chemical-species mass fluxes were derived from fluctuation-dissipation theory and incorporate Soret and Dufour effects. Similarity equations for the streamwise velocity, temperature, and mass fractions were derived as approximations to the governing equations. Similarity profiles showed important real-gas, non-ideal-mixture effects, particularly for temperature, in departing from the error-function profile, which is the similarity solution for incompressible flow. The temperature behavior was attributed to real-gas thermodynamics and variations in Schmidt and Prandtl numbers. Temporal linear inviscid stability analyses were performed using the similarity and error-function profiles as the mean flow. For the similarity profiles, the growth rates were found to be larger and the wavelengths of highest instability shorter, relative to those of the errorfunction profiles and to those obtained from incompressible-flow stability analysis. The range of unstable wavelengths was found to be larger for the similarity profiles than for the error-function profiles

Visualization and analysis of pulsed ion beam energy density profile with infrared imaging

NASA Astrophysics Data System (ADS)

Isakova, Y. I.; Pushkarev, A. I.

2018-03-01

Infrared imaging technique was used as a surface temperature-mapping tool to characterize the energy density distribution of intense pulsed ion beams on a thin metal target. The technique enables the measuring of the total ion beam energy and the energy density distribution along the cross section and allows one to optimize the operation of an ion diode and control target irradiation mode. The diagnostics was tested on the TEMP-4M accelerator at TPU, Tomsk, Russia and on the TEMP-6 accelerator at DUT, Dalian, China. The diagnostics was applied in studies of the dynamics of the target cooling in vacuum after irradiation and in the experiments with target ablation. Errors caused by the target ablation and target cooling during measurements have been analyzed. For Fluke Ti10 and Fluke Ti400 infrared cameras, the technique can achieve surface energy density sensitivity of 0.05 J/cm2 and spatial resolution of 1-2 mm. The thermal imaging diagnostics does not require expensive consumed materials. The measurement time does not exceed 0.1 s; therefore, this diagnostics can be used for the prompt evaluation of the energy density distribution of a pulsed ion beam and during automation of the irradiation process.

Reduction of body fat and improved lipid profile associated with daily consumption of a Puer tea extract in a hyperlipidemic population: a randomized placebo-controlled trial

PubMed Central

Jensen, Gitte S; Beaman, Joni L; He, Yi; Guo, Zhixin; Sun, Henry

2016-01-01

Objective The goal for this study was to evaluate the effects of daily consumption of Puer tea extract (PTE) on body weight, body-fat composition, and lipid profile in a non-Asian population in the absence of dietary restrictions. Materials and methods A randomized, double-blind, placebo-controlled study design was used. A total of 59 overweight or mildly obese subjects were enrolled upon screening to confirm fasting cholesterol level at or above 220 mg/dL (5.7 mmol/dL). After giving informed consent, subjects were randomized to consume PTE (3 g/day) or placebo for 20 weeks. At baseline and at 4-week intervals, blood lipids, C-reactive protein, and fasting blood glucose were evaluated. A dual-energy X-ray absorptiometry scan was performed at baseline and at study exit to evaluate changes to body composition. Appetite and physical and mental energy were scored at each visit using visual analog scales (0–100). Results Consumption of PTE was associated with statistically significant weight loss when compared to placebo (P<0.05). Fat loss was seen for arms, legs, and the gynoid region (hip/belly), as well as for total fat mass. The fat reduction reached significance on within-group analysis, but did not reach between-group significance. Consumption of PTE was associated with improvements to lipid profile, including a mild reduction in cholesterol and the cholesterol:high-density lipoprotein ratio after only 4 weeks, as well as a reduction in triglycerides and very small-density lipoproteins, where average blood levels reached normal range at 8 weeks and remained within normal range for the duration of the study (P<0.08). No significant changes between the PTE group and the placebo group were seen for fasting glucose or C-reactive protein. A transient reduction in appetite was seen in the PTE group when compared to placebo (P<0.1). Conclusion The results from this clinical study showed that the daily consumption of PTE was associated with significant weight loss, reduced body mass index, and an improved lipid profile. PMID:27069360

Vitamin E tocotrienol supplementation improves lipid profiles in chronic hemodialysis patients

PubMed Central

Daud, Zulfitri A Mat; Tubie, Boniface; Sheyman, Marina; Osia, Robert; Adams, Judy; Tubie, Sharon; Khosla, Pramod

2013-01-01

Purpose Chronic hemodialysis patients experience accelerated atherosclerosis contributed to by dyslipidemia, inflammation, and an impaired antioxidant system. Vitamin E tocotrienols possess anti-inflammatory and antioxidant properties. However, the impact of dietary intervention with Vitamin E tocotrienols is unknown in this population. Patients and methods A randomized, double-blind, placebo-controlled, parallel trial was conducted in 81 patients undergoing chronic hemodialysis. Subjects were provided daily with capsules containing either vitamin E tocotrienol-rich fraction (TRF) (180 mg tocotrienols, 40 mg tocopherols) or placebo (0.48 mg tocotrienols, 0.88 mg tocopherols). Endpoints included measurements of inflammatory markers (C-reactive protein and interleukin 6), oxidative status (total antioxidant power and malondialdehyde), lipid profiles (plasma total cholesterol, triacylglycerols, and high-density lipoprotein cholesterol), as well as cholesteryl-ester transfer protein activity and apolipoprotein A1. Results TRF supplementation did not impact any nutritional, inflammatory, or oxidative status biomarkers over time when compared with the baseline within the group (one-way repeated measures analysis of variance) or when compared with the placebo group at a particular time point (independent t-test). However, the TRF supplemented group showed improvement in lipid profiles after 12 and 16 weeks of intervention when compared with placebo at the respective time points. Normalized plasma triacylglycerols (cf baseline) in the TRF group were reduced by 33 mg/dL (P=0.032) and 36 mg/dL (P=0.072) after 12 and 16 weeks of intervention but no significant improvement was seen in the placebo group. Similarly, normalized plasma high-density lipoprotein cholesterol was higher (P<0.05) in the TRF group as compared with placebo at both week 12 and week 16. The changes in the TRF group at week 12 and week 16 were associated with higher plasma apolipoprotein A1 concentration (P<0.02) and lower cholesteryl-ester transfer protein activity (P<0.001). Conclusion TRF supplementation improved lipid profiles in this study of maintenance hemodialysis patients. A multi-centered trial is warranted to confirm these observations. PMID:24348043

Local ensemble transform Kalman filter for ionospheric data assimilation: Observation influence analysis during a geomagnetic storm event

NASA Astrophysics Data System (ADS)

Durazo, Juan A.; Kostelich, Eric J.; Mahalov, Alex

2017-09-01

We propose a targeted observation strategy, based on the influence matrix diagnostic, that optimally selects where additional observations may be placed to improve ionospheric forecasts. This strategy is applied in data assimilation observing system experiments, where synthetic electron density vertical profiles, which represent those of Constellation Observing System for Meteorology, Ionosphere, and Climate/Formosa satellite 3, are assimilated into the Thermosphere-Ionosphere-Electrodynamics General Circulation Model using the local ensemble transform Kalman filter during the 26 September 2011 geomagnetic storm. During each analysis step, the observation vector is augmented with five synthetic vertical profiles optimally placed to target electron density errors, using our targeted observation strategy. Forecast improvement due to assimilation of augmented vertical profiles is measured with the root-mean-square error (RMSE) of analyzed electron density, averaged over 600 km regions centered around the augmented vertical profile locations. Assimilating vertical profiles with targeted locations yields about 60%-80% reduction in electron density RMSE, compared to a 15% average reduction when assimilating randomly placed vertical profiles. Assimilating vertical profiles whose locations target the zonal component of neutral winds (Un) yields on average a 25% RMSE reduction in Un estimates, compared to a 2% average improvement obtained with randomly placed vertical profiles. These results demonstrate that our targeted strategy can improve data assimilation efforts during extreme events by detecting regions where additional observations would provide the largest benefit to the forecast.