Sample records for trailing cable overload

  1. 30 CFR 57.12003 - Trailing cable overload protection.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Trailing cable overload protection. 57.12003... Electricity Surface and Underground § 57.12003 Trailing cable overload protection. Individual overload protection or short circuit protection shall be provided for the trailing cables of mobile equipment. ...

  2. 30 CFR 56.12003 - Trailing cable overload protection.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Trailing cable overload protection. 56.12003 Section 56.12003 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity...

  3. 30 CFR 56.12003 - Trailing cable overload protection.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Trailing cable overload protection. 56.12003 Section 56.12003 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity...

  4. 30 CFR 56.12003 - Trailing cable overload protection.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Trailing cable overload protection. 56.12003 Section 56.12003 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity...

  5. 30 CFR 56.12003 - Trailing cable overload protection.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Trailing cable overload protection. 56.12003 Section 56.12003 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity...

  6. 30 CFR 56.12003 - Trailing cable overload protection.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Trailing cable overload protection. 56.12003 Section 56.12003 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity...

  7. 30 CFR 57.12003 - Trailing cable overload protection.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Trailing cable overload protection. 57.12003 Section 57.12003 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Electricity Surface and Underground § 57.12003...

  8. 30 CFR 57.12003 - Trailing cable overload protection.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Trailing cable overload protection. 57.12003 Section 57.12003 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Electricity Surface and Underground § 57.12003...

  9. 30 CFR 57.12003 - Trailing cable overload protection.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Trailing cable overload protection. 57.12003 Section 57.12003 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Electricity Surface and Underground § 57.12003...

  10. 30 CFR 57.12003 - Trailing cable overload protection.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Trailing cable overload protection. 57.12003 Section 57.12003 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Electricity Surface and Underground § 57.12003...

  11. 30 CFR 77.605 - Breaking trailing cable and power cable connections.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Breaking trailing cable and power cable... OF UNDERGROUND COAL MINES Trailing Cables § 77.605 Breaking trailing cable and power cable connections. Trailing cable and power cable connections between cables and to power sources shall not be made...

  12. 30 CFR 77.605 - Breaking trailing cable and power cable connections.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Breaking trailing cable and power cable... OF UNDERGROUND COAL MINES Trailing Cables § 77.605 Breaking trailing cable and power cable connections. Trailing cable and power cable connections between cables and to power sources shall not be made...

  13. 30 CFR 77.605 - Breaking trailing cable and power cable connections.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Breaking trailing cable and power cable... OF UNDERGROUND COAL MINES Trailing Cables § 77.605 Breaking trailing cable and power cable connections. Trailing cable and power cable connections between cables and to power sources shall not be made...

  14. 30 CFR 77.605 - Breaking trailing cable and power cable connections.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Breaking trailing cable and power cable... OF UNDERGROUND COAL MINES Trailing Cables § 77.605 Breaking trailing cable and power cable connections. Trailing cable and power cable connections between cables and to power sources shall not be made...

  15. 30 CFR 77.605 - Breaking trailing cable and power cable connections.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Breaking trailing cable and power cable... OF UNDERGROUND COAL MINES Trailing Cables § 77.605 Breaking trailing cable and power cable connections. Trailing cable and power cable connections between cables and to power sources shall not be made...

  16. 30 CFR 77.601 - Trailing cables or portable cables; temporary splices.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Trailing cables or portable cables; temporary... OF UNDERGROUND COAL MINES Trailing Cables § 77.601 Trailing cables or portable cables; temporary splices. Temporary splices in trailing cables or portable cables shall be made in a workmanlike manner and...

  17. 30 CFR 75.607 - Breaking trailing cable and power cable connections.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Breaking trailing cable and power cable... LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Trailing Cables § 75.607 Breaking trailing cable and power cable connections. [Statutory Provisions] Trailing cable and...

  18. 30 CFR 75.607 - Breaking trailing cable and power cable connections.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Breaking trailing cable and power cable....607 Breaking trailing cable and power cable connections. [Statutory Provisions] Trailing cable and power cable connections to junction boxes shall not be made or broken under load. ...

  19. 30 CFR 75.607 - Breaking trailing cable and power cable connections.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Breaking trailing cable and power cable....607 Breaking trailing cable and power cable connections. [Statutory Provisions] Trailing cable and power cable connections to junction boxes shall not be made or broken under load. ...

  20. 30 CFR 75.607 - Breaking trailing cable and power cable connections.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Breaking trailing cable and power cable....607 Breaking trailing cable and power cable connections. [Statutory Provisions] Trailing cable and power cable connections to junction boxes shall not be made or broken under load. ...

  1. 30 CFR 75.607 - Breaking trailing cable and power cable connections.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Breaking trailing cable and power cable....607 Breaking trailing cable and power cable connections. [Statutory Provisions] Trailing cable and power cable connections to junction boxes shall not be made or broken under load. ...

  2. 30 CFR 75.600 - Trailing cables; flame resistance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Trailing cables; flame resistance. 75.600... SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Trailing Cables § 75.600 Trailing cables; flame resistance. [Statutory Provisions] Trailing cables used in coal mines shall meet the...

  3. 30 CFR 75.606 - Protection of trailing cables.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Protection of trailing cables. 75.606 Section... AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Trailing Cables § 75.606 Protection of trailing cables. [Statutory Provisions] Trailing cables shall be adequately protected to prevent damage by...

  4. 30 CFR 75.826 - High-voltage trailing cables.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false High-voltage trailing cables. 75.826 Section 75...-Voltage Longwalls § 75.826 High-voltage trailing cables. High-voltage trailing cables must: (a) Meet existing trailing cable requirements and the approval requirements of the high-voltage continuous mining...

  5. 30 CFR 75.601 - Short circuit protection of trailing cables.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Short circuit protection of trailing cables. 75... MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Trailing Cables § 75.601 Short circuit protection of trailing cables. [Statutory Provisions] Short circuit protection for trailing cables...

  6. 30 CFR 77.603 - Clamping of trailing cables to equipment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Clamping of trailing cables to equipment. 77.603 Section 77.603 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL... UNDERGROUND COAL MINES Trailing Cables § 77.603 Clamping of trailing cables to equipment. Trailing cables...

  7. 30 CFR 75.603 - Temporary splice of trailing cable.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Temporary splice of trailing cable. 75.603... SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Trailing Cables § 75.603 Temporary splice of trailing cable. [Statutory Provision] One temporary splice may be made in any trailing cable...

  8. 30 CFR 75.602 - Trailing cable junctions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Trailing cable junctions. 75.602 Section 75.602... MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Trailing Cables § 75.602 Trailing cable junctions. [Statutory Provision] When two or more trailing cables junction to the same distribution center, means shall...

  9. 30 CFR 75.604 - Permanent splicing of trailing cables.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Permanent splicing of trailing cables. 75.604... SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Trailing Cables § 75.604 Permanent splicing of trailing cables. [Statutory Provisions] When permanent splices in trailing cables are made...

  10. 30 CFR 77.602 - Permanent splicing of trailing cables.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Permanent splicing of trailing cables. 77.602... COAL MINES Trailing Cables § 77.602 Permanent splicing of trailing cables. When permanent splices in trailing cables are made, they shall be: (a) Mechanically strong with adequate electrical conductivity; (b...

  11. 30 CFR 77.604 - Protection of trailing cables.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Protection of trailing cables. 77.604 Section 77.604 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY... MINES Trailing Cables § 77.604 Protection of trailing cables. Trailing cables shall be adequately...

  12. 30 CFR 77.606 - Energized trailing cables; handling.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Energized trailing cables; handling. 77.606... COAL MINES Trailing Cables § 77.606 Energized trailing cables; handling. Energized medium- and high-voltage trailing cables shall be handled only by persons wearing protective rubber gloves (see § 77.606-1...

  13. 30 CFR 75.605 - Clamping of trailing cables to equipment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Clamping of trailing cables to equipment. 75... MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Trailing Cables § 75.605 Clamping of trailing cables to equipment. [Statutory Provisions] Trailing cables shall be clamped to...

  14. 30 CFR 77.600 - Trailing cables; short-circuit protection; disconnecting devices.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Trailing cables; short-circuit protection... AREAS OF UNDERGROUND COAL MINES Trailing Cables § 77.600 Trailing cables; short-circuit protection; disconnecting devices. Short-circuit protection for trailing cables shall be provided by an automatic circuit...

  15. 30 CFR 77.600 - Trailing cables; short-circuit protection; disconnecting devices.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... capacity in each ungrounded conductor. Disconnecting devices used to disconnect power from trailing cables... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Trailing cables; short-circuit protection... AREAS OF UNDERGROUND COAL MINES Trailing Cables § 77.600 Trailing cables; short-circuit protection...

  16. 30 CFR 77.600 - Trailing cables; short-circuit protection; disconnecting devices.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... capacity in each ungrounded conductor. Disconnecting devices used to disconnect power from trailing cables... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Trailing cables; short-circuit protection... AREAS OF UNDERGROUND COAL MINES Trailing Cables § 77.600 Trailing cables; short-circuit protection...

  17. 30 CFR 77.600 - Trailing cables; short-circuit protection; disconnecting devices.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... capacity in each ungrounded conductor. Disconnecting devices used to disconnect power from trailing cables... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Trailing cables; short-circuit protection... AREAS OF UNDERGROUND COAL MINES Trailing Cables § 77.600 Trailing cables; short-circuit protection...

  18. 30 CFR 77.600 - Trailing cables; short-circuit protection; disconnecting devices.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... capacity in each ungrounded conductor. Disconnecting devices used to disconnect power from trailing cables... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Trailing cables; short-circuit protection... AREAS OF UNDERGROUND COAL MINES Trailing Cables § 77.600 Trailing cables; short-circuit protection...

  19. 30 CFR 75.828 - Trailing cable pulling.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Trailing cable pulling. 75.828 Section 75.828... Longwalls § 75.828 Trailing cable pulling. The trailing cable must be de-energized prior to being pulled by... procedures must be followed when pulling the trailing cable with equipment other than the continuous mining...

  20. 30 CFR 18.35 - Portable (trailing) cables and cords.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Portable (trailing) cables and cords. 18.35... and Design Requirements § 18.35 Portable (trailing) cables and cords. (a) Portable cables and cords... a portable (trailing) cable shall not exceed 500 feet. Where the method of mining requires the...

  1. 30 CFR 75.833 - Handling high-voltage trailing cables.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Handling high-voltage trailing cables. 75.833... High-Voltage Longwalls § 75.833 Handling high-voltage trailing cables. (a) Cable handling. (1) Miners must not handle energized trailing cables unless they are wearing high-voltage insulating gloves, which...

  2. 30 CFR 75.810 - High-voltage trailing cables; splices.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false High-voltage trailing cables; splices. 75.810... § 75.810 High-voltage trailing cables; splices. [Statutory Provisions] In the case of high-voltage cables used as trailing cables, temporary splices shall not be used and all permanent splices shall be...

  3. 30 CFR 57.12038 - Attachment of trailing cables.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Attachment of trailing cables. 57.12038 Section 57.12038 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND... Electricity Surface and Underground § 57.12038 Attachment of trailing cables. Trailing cables shall be...

  4. 30 CFR 57.4057 - Underground trailing cables.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... and Control § 57.4057 Underground trailing cables. Underground trailing cables shall be accepted or... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Underground trailing cables. 57.4057 Section 57.4057 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL...

  5. 30 CFR 57.4057 - Underground trailing cables.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... and Control § 57.4057 Underground trailing cables. Underground trailing cables shall be accepted or... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Underground trailing cables. 57.4057 Section 57.4057 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL...

  6. 30 CFR 57.4057 - Underground trailing cables.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... and Control § 57.4057 Underground trailing cables. Underground trailing cables shall be accepted or... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Underground trailing cables. 57.4057 Section 57.4057 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL...

  7. 30 CFR 57.4057 - Underground trailing cables.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... and Control § 57.4057 Underground trailing cables. Underground trailing cables shall be accepted or... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Underground trailing cables. 57.4057 Section 57.4057 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL...

  8. 30 CFR 75.907 - Design of trailing cables for medium-voltage circuits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Design of trailing cables for medium-voltage... Medium-Voltage Alternating Current Circuits § 75.907 Design of trailing cables for medium-voltage circuits. [Statutory Provisions] Trailing cables for medium-voltage circuits shall include grounding...

  9. 30 CFR 77.804 - High-voltage trailing cables; minimum design requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false High-voltage trailing cables; minimum design... OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.804 High-voltage trailing cables; minimum design requirements. (a) High-voltage trailing cables used in resistance grounded systems shall be...

  10. 30 CFR 57.12039 - Protection of surplus trailing cables.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Protection of surplus trailing cables. 57.12039 Section 57.12039 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND... Electricity Surface and Underground § 57.12039 Protection of surplus trailing cables. Surplus trailing cables...

  11. 30 CFR 77.804 - High-voltage trailing cables; minimum design requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false High-voltage trailing cables; minimum design... OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.804 High-voltage trailing cables; minimum design requirements. (a) High-voltage trailing cables used in resistance grounded systems shall be...

  12. 30 CFR 75.601 - Short circuit protection of trailing cables.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... to disconnect power from trailing cables shall be plainly marked and identified and such devices... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Short circuit protection of trailing cables. 75... MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Trailing Cables § 75.601 Short...

  13. 30 CFR 75.601 - Short circuit protection of trailing cables.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... to disconnect power from trailing cables shall be plainly marked and identified and such devices... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Short circuit protection of trailing cables. 75... MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Trailing Cables § 75.601 Short...

  14. 30 CFR 77.804 - High-voltage trailing cables; minimum design requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false High-voltage trailing cables; minimum design... OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.804 High-voltage trailing cables; minimum design requirements. (a) High-voltage trailing cables used in resistance grounded systems shall be...

  15. 30 CFR 75.601 - Short circuit protection of trailing cables.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... to disconnect power from trailing cables shall be plainly marked and identified and such devices... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Short circuit protection of trailing cables. 75... MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Trailing Cables § 75.601 Short...

  16. 30 CFR 75.601 - Short circuit protection of trailing cables.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... to disconnect power from trailing cables shall be plainly marked and identified and such devices... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Short circuit protection of trailing cables. 75... MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Trailing Cables § 75.601 Short...

  17. 30 CFR 77.804 - High-voltage trailing cables; minimum design requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false High-voltage trailing cables; minimum design... OF UNDERGROUND COAL MINES Surface High-Voltage Distribution § 77.804 High-voltage trailing cables; minimum design requirements. (a) High-voltage trailing cables used in resistance grounded systems shall be...

  18. 30 CFR 75.907 - Design of trailing cables for medium-voltage circuits.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Design of trailing cables for medium-voltage... Medium-Voltage Alternating Current Circuits § 75.907 Design of trailing cables for medium-voltage circuits. [Statutory Provisions] Trailing cables for medium-voltage circuits shall include grounding...

  19. 30 CFR 75.907 - Design of trailing cables for medium-voltage circuits.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Design of trailing cables for medium-voltage... Medium-Voltage Alternating Current Circuits § 75.907 Design of trailing cables for medium-voltage circuits. [Statutory Provisions] Trailing cables for medium-voltage circuits shall include grounding...

  20. 30 CFR 75.907 - Design of trailing cables for medium-voltage circuits.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Design of trailing cables for medium-voltage... Medium-Voltage Alternating Current Circuits § 75.907 Design of trailing cables for medium-voltage circuits. [Statutory Provisions] Trailing cables for medium-voltage circuits shall include grounding...

  1. 30 CFR 75.907 - Design of trailing cables for medium-voltage circuits.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Design of trailing cables for medium-voltage... Medium-Voltage Alternating Current Circuits § 75.907 Design of trailing cables for medium-voltage circuits. [Statutory Provisions] Trailing cables for medium-voltage circuits shall include grounding...

  2. 30 CFR 57.12088 - Splicing trailing cables.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Splicing trailing cables. 57.12088 Section 57... Underground Only § 57.12088 Splicing trailing cables. No splice, except a vulcanized splice or its equivalent, shall be made in a trailing cable within 25 feet of the machine unless the machine is equipped with a...

  3. 30 CFR 75.906 - Trailing cables for mobile equipment, ground wires, and ground check wires.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Trailing cables for mobile equipment, ground... Underground Low- and Medium-Voltage Alternating Current Circuits § 75.906 Trailing cables for mobile equipment, ground wires, and ground check wires. [Statutory Provisions] Trailing cables for mobile equipment shall...

  4. 30 CFR 75.906 - Trailing cables for mobile equipment, ground wires, and ground check wires.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Trailing cables for mobile equipment, ground... Underground Low- and Medium-Voltage Alternating Current Circuits § 75.906 Trailing cables for mobile equipment, ground wires, and ground check wires. [Statutory Provisions] Trailing cables for mobile equipment shall...

  5. 30 CFR 75.906 - Trailing cables for mobile equipment, ground wires, and ground check wires.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Trailing cables for mobile equipment, ground... Underground Low- and Medium-Voltage Alternating Current Circuits § 75.906 Trailing cables for mobile equipment, ground wires, and ground check wires. [Statutory Provisions] Trailing cables for mobile equipment shall...

  6. 30 CFR 75.830 - Splicing and repair of trailing cables.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Splicing and repair of trailing cables. 75.830... High-Voltage Longwalls § 75.830 Splicing and repair of trailing cables. (a) Splices and repairs. (1... and repairs to high-voltage trailing cables must be made: (i) Only by a qualified person trained in...

  7. 30 CFR 57.12088 - Splicing trailing cables.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... cable reel or other power feed cable payout-retrieval system. However, a temporary splice may be made to... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Splicing trailing cables. 57.12088 Section 57... Underground Only § 57.12088 Splicing trailing cables. No splice, except a vulcanized splice or its equivalent...

  8. 30 CFR 57.12088 - Splicing trailing cables.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... cable reel or other power feed cable payout-retrieval system. However, a temporary splice may be made to... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Splicing trailing cables. 57.12088 Section 57... Underground Only § 57.12088 Splicing trailing cables. No splice, except a vulcanized splice or its equivalent...

  9. 30 CFR 57.12088 - Splicing trailing cables.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... cable reel or other power feed cable payout-retrieval system. However, a temporary splice may be made to... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Splicing trailing cables. 57.12088 Section 57... Underground Only § 57.12088 Splicing trailing cables. No splice, except a vulcanized splice or its equivalent...

  10. 30 CFR 57.12088 - Splicing trailing cables.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... cable reel or other power feed cable payout-retrieval system. However, a temporary splice may be made to... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Splicing trailing cables. 57.12088 Section 57... Underground Only § 57.12088 Splicing trailing cables. No splice, except a vulcanized splice or its equivalent...

  11. 30 CFR 77.906 - Trailing cables supplying power to low-voltage mobile equipment; ground wires and ground check...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Trailing cables supplying power to low-voltage... Alternating Current Circuits § 77.906 Trailing cables supplying power to low-voltage mobile equipment; ground wires and ground check wires. On and after September 30, 1971, all trailing cables supplying power to...

  12. 30 CFR 77.906 - Trailing cables supplying power to low-voltage mobile equipment; ground wires and ground check...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Trailing cables supplying power to low-voltage... Alternating Current Circuits § 77.906 Trailing cables supplying power to low-voltage mobile equipment; ground wires and ground check wires. On and after September 30, 1971, all trailing cables supplying power to...

  13. 30 CFR 77.906 - Trailing cables supplying power to low-voltage mobile equipment; ground wires and ground check...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Trailing cables supplying power to low-voltage... Alternating Current Circuits § 77.906 Trailing cables supplying power to low-voltage mobile equipment; ground wires and ground check wires. On and after September 30, 1971, all trailing cables supplying power to...

  14. 7. SHOWING METHOD OF SLEDDING WIND CABLE DOWN YAKI TRAIL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. SHOWING METHOD OF SLEDDING WIND CABLE DOWN YAKI TRAIL TO THE BRIDGE, WEIGHT OF CABLE AND DRUM APPROXIMATELY 2200 POUNDS - Kaibab Trail Suspension Bridge, Spanning Colorado River, Grand Canyon, Coconino County, AZ

  15. 30 CFR 75.830 - Splicing and repair of trailing cables.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... high-voltage trailing cable within 35 feet of the continuous mining machine is prohibited. (2) Only four (4) splices will be allowed at any one time for the portion of the trailing cable that extends...

  16. 30 CFR 75.830 - Splicing and repair of trailing cables.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... high-voltage trailing cable within 35 feet of the continuous mining machine is prohibited. (2) Only four (4) splices will be allowed at any one time for the portion of the trailing cable that extends...

  17. 30 CFR 75.827 - Guarding of trailing cables.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Guarding of trailing cables. 75.827 Section 75.827 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND...-Voltage Longwalls § 75.827 Guarding of trailing cables. (a) Guarding. (1) The high-voltage cable must be...

  18. 30 CFR 28.1 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PRODUCTS FUSES FOR USE WITH DIRECT CURRENT IN PROVIDING SHORT-CIRCUIT PROTECTION FOR TRAILING CABLES IN... trailing cables in coal mines, or the approval of changes or modifications of approved fuses; (b) to...-circuit protection for trailing cables in coal mines; and (c) to provide for the issuance of certificates...

  19. 30 CFR 77.606-1 - Rubber gloves; minimum requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... COAL MINES Trailing Cables § 77.606-1 Rubber gloves; minimum requirements. (a) Rubber gloves (lineman's gloves) worn while handling high-voltage trailing cables shall be rated at least 20,000 volts and shall... gloves (wireman's gloves) worn while handling trailing cables energized by 660 to 1,000 volts shall be...

  20. 30 CFR 75.906 - Trailing cables for mobile equipment, ground wires, and ground check wires.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Trailing cables for mobile equipment, ground wires, and ground check wires. 75.906 Section 75.906 Mineral Resources MINE SAFETY AND HEALTH..., ground wires, and ground check wires. [Statutory Provisions] Trailing cables for mobile equipment shall...

  1. 30 CFR 75.906 - Trailing cables for mobile equipment, ground wires, and ground check wires.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Trailing cables for mobile equipment, ground wires, and ground check wires. 75.906 Section 75.906 Mineral Resources MINE SAFETY AND HEALTH..., ground wires, and ground check wires. [Statutory Provisions] Trailing cables for mobile equipment shall...

  2. Overload characteristics of paper-polypropylene-paper cable

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ernst, A.

    1990-09-01

    The short-time rating of PPP pipe-type cable may be lower than the equivalent paper cable sized to carry the same normal load. The ratings depend on the relative conductor sizes and the maximum allowable conductor temperatures of the insulation. The insulation thermal resistivity may be a significant parameter for overload times of approximately one hour and should be verified for PPP insulation. The thermal capacitance temperature characteristic of PPP insulation is not known. However, the overload ratings are not very sensitive to this parameter. Overload ratings are given for maximum conductor temperatures from 105 C to 130 C. Use ofmore » ratings based on temperatures greater than 105 C would require testing to determine the extent of degradation of the insulation at these higher temperatures. PPP-insulated cable will be thermally stable over a wider range of operating conditions (voltage and current) compared with paper-insulated cable. The short-circuit ratings of PPP- and paper-insulated cable systems and the positive/negative and zero sequence impedances are compared. 21 refs., 22 figs., 5 tabs.« less

  3. 30 CFR 77.906 - Trailing cables supplying power to low-voltage mobile equipment; ground wires and ground check...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Trailing cables supplying power to low-voltage mobile equipment; ground wires and ground check wires. 77.906 Section 77.906 Mineral Resources MINE... wires and ground check wires. On and after September 30, 1971, all trailing cables supplying power to...

  4. 30 CFR 77.906 - Trailing cables supplying power to low-voltage mobile equipment; ground wires and ground check...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Trailing cables supplying power to low-voltage mobile equipment; ground wires and ground check wires. 77.906 Section 77.906 Mineral Resources MINE... wires and ground check wires. On and after September 30, 1971, all trailing cables supplying power to...

  5. 30 CFR 75.831 - Electrical work; troubleshooting and testing.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) or (2): (1) If a trailing cable disconnecting switch is provided: (i) Open and ground the power... power receptacle. (b) Troubleshooting and testing the trailing cable. During troubleshooting and testing, the de-energized high-voltage cable may be disconnected from the power center only for that period of...

  6. 30 CFR 75.831 - Electrical work; troubleshooting and testing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) or (2): (1) If a trailing cable disconnecting switch is provided: (i) Open and ground the power... power receptacle. (b) Troubleshooting and testing the trailing cable. During troubleshooting and testing, the de-energized high-voltage cable may be disconnected from the power center only for that period of...

  7. 30 CFR 75.831 - Electrical work; troubleshooting and testing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) or (2): (1) If a trailing cable disconnecting switch is provided: (i) Open and ground the power... power receptacle. (b) Troubleshooting and testing the trailing cable. During troubleshooting and testing, the de-energized high-voltage cable may be disconnected from the power center only for that period of...

  8. 30 CFR 75.831 - Electrical work; troubleshooting and testing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) or (2): (1) If a trailing cable disconnecting switch is provided: (i) Open and ground the power... power receptacle. (b) Troubleshooting and testing the trailing cable. During troubleshooting and testing, the de-energized high-voltage cable may be disconnected from the power center only for that period of...

  9. Experimental Investigations on Combustion Behaviors of Live PVC Cables

    NASA Astrophysics Data System (ADS)

    Wang, Liufang; Zhang, Jiaqing; Zhang, Bosi; Liu, Min; Fan, Minghao; Li, Qiang

    2018-03-01

    This paper investigated the combustion behaviors of live PVC cables with overload currents experimentally. The smoke coefficient of released smoke and the released gas concentration were examined. The results indicate that the combustion of live PVC cables can be divided into four stages, i.e., core exposed with a little smoke, obvious flame, maximum smoke and smoke depress. For most cases, using blue laser is better than using rad laser, since the extinction coefficient of the rad laser was larger than that of the blue laser. The response time of the detection of the released typical gases due to cable pyrolysis decreased and the peak values of the typical gases increased with the overload currents. In addition, the time to reach the peak value of gas concentration also decreased with the overload currents.

  10. A comparison between the ANSI/IEEE and the CENELEC/IEC approach to overload protection of insulated power cables

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Parise, G.; Rubino, G.

    1995-12-31

    The same basic principles, on which the methods of power cables protection against overloads are based, are summed up by different criteria and formulations within ANSI/IEEE and CENELEC/IEC publications. The studies carried out by the technical committees of these organizations have been examined and compared in order to point out not only their differences but also their complementary aspects. By arranging the two approaches, it has been possible to outline a third way to determine the admissible duration of overload currents and define intermediate criteria for the emergency ratings of cables and for the coordination of protective devices.

  11. 30 CFR 28.40 - Construction and performance requirements; general.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-CIRCUIT PROTECTION FOR TRAILING CABLES IN COAL MINES Construction, Performance, and Testing Requirements... for use with direct current in providing short-circuit protection for trailing cables, when such fuses...

  12. 46 CFR 111.12-9 - Generator cables.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Generator cables. 111.12-9 Section 111.12-9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL...) Less than 115 percent of the overload for a machine with a 2 hour or greater overload rating. (b...

  13. System for effecting underwater coupling of optical fiber cables characterized by a novel V-probe cable capture mechanism

    NASA Astrophysics Data System (ADS)

    Hillenbrand, Christopher F.; Barron, Thomas D.; Nugent, David M.

    1995-03-01

    A submarine trails one fiber optic cable and an undersea vehicle is controlled by this first cable. A missile/torpedo trails a second cable that is to be coupled to the first cable. The second cable has a segment suspended vertically underwater between a buoyant pod and a sea anchor type buoy. The undersea vehicle, or Autonomous Undersea Vehicle, (AUV) hunts for the pod by conventional homing means. A forked cable pickup device in the nose of the AUV captures the suspended cable segment directing it into a slot so a male socket in the underside of the pod mates with a female socket in the slot.

  14. 30 CFR 28.3 - Installation, use, and maintenance of approved fuses.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-CIRCUIT PROTECTION FOR TRAILING CABLES IN COAL MINES General Provisions § 28.3 Installation, use, and... standards prescribed for short-circuit protective devices for trailing cables in Parts 75 and 77, Subchapter...

  15. 30 CFR 75.601-1 - Short circuit protection; ratings and settings of circuit breakers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Trailing Cables § 75.601-1 Short circuit protection; ratings and settings of circuit breakers. Circuit breakers providing short circuit protection for trailing cables shall be set so as not to exceed the...

  16. 30 CFR 75.601-2 - Short circuit protection; use of fuses; approval by the Secretary.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Trailing Cables § 75.601-2 Short circuit protection; use of fuses; approval by the Secretary. Fuses shall not be employed to provide short circuit protection for trailing cables unless specifically approved...

  17. 30 CFR 75.827 - Guarding of trailing cables.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... grounded metal. (b) Suspended cables and cable crossovers. When equipment must cross any portion of the cable, the cable must be either: (1) Suspended from the mine roof; or (2) Protected by a cable crossover...

  18. 30 CFR 75.827 - Guarding of trailing cables.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... grounded metal. (b) Suspended cables and cable crossovers. When equipment must cross any portion of the cable, the cable must be either: (1) Suspended from the mine roof; or (2) Protected by a cable crossover...

  19. 30 CFR 75.827 - Guarding of trailing cables.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... grounded metal. (b) Suspended cables and cable crossovers. When equipment must cross any portion of the cable, the cable must be either: (1) Suspended from the mine roof; or (2) Protected by a cable crossover...

  20. 30 CFR 75.827 - Guarding of trailing cables.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... grounded metal. (b) Suspended cables and cable crossovers. When equipment must cross any portion of the cable, the cable must be either: (1) Suspended from the mine roof; or (2) Protected by a cable crossover...

  1. 30 CFR 75.601-3 - Short circuit protection; dual element fuses; current ratings; maximum values.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Trailing Cables § 75.601-3 Short circuit protection; dual element fuses; current ratings; maximum values... circuit protection of trailing cables as provided in § 75.601, however, the current ratings of such...

  2. Changes in soil bulk density resulting from construction and conventional cable skidding using preplanned skid trails

    Treesearch

    Jingxin Wang; Chris B. LeDoux; Pam Edwards

    2007-01-01

    A harvesting system consisting of chainsaw felling and cable skidder extraction was studied to determine soil bulk density changes in a central Appalachian hardwood forest site. Soil bulk density was measured using a nuclear gauge preharvest and postharvest systematically across the harvest site, on transects across skid trails, and for a subset of skid trail transects...

  3. 30 CFR 56.12038 - Attachment of trailing cables.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Attachment of trailing cables. 56.12038 Section 56.12038 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity...

  4. 30 CFR 56.12038 - Attachment of trailing cables.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Attachment of trailing cables. 56.12038 Section 56.12038 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity...

  5. 30 CFR 56.12038 - Attachment of trailing cables.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Attachment of trailing cables. 56.12038 Section 56.12038 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity...

  6. 30 CFR 56.12038 - Attachment of trailing cables.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Attachment of trailing cables. 56.12038 Section 56.12038 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity...

  7. 30 CFR 56.12038 - Attachment of trailing cables.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Attachment of trailing cables. 56.12038 Section 56.12038 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity...

  8. 30 CFR 57.4057 - Underground trailing cables.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Underground trailing cables. 57.4057 Section 57.4057 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Fire Prevention...

  9. 30 CFR 56.12039 - Protection of surplus trailing cables.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Protection of surplus trailing cables. 56.12039 Section 56.12039 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity...

  10. 30 CFR 56.12039 - Protection of surplus trailing cables.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Protection of surplus trailing cables. 56.12039 Section 56.12039 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity...

  11. 30 CFR 56.12039 - Protection of surplus trailing cables.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Protection of surplus trailing cables. 56.12039 Section 56.12039 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity...

  12. 30 CFR 56.12039 - Protection of surplus trailing cables.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Protection of surplus trailing cables. 56.12039 Section 56.12039 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity...

  13. 30 CFR 56.12039 - Protection of surplus trailing cables.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Protection of surplus trailing cables. 56.12039 Section 56.12039 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Electricity...

  14. 30 CFR 28.21 - Certificates of approval; contents.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PROTECTION FOR TRAILING CABLES IN COAL MINES Approval and Disapproval § 28.21 Certificates of approval... protection for trailing cables. (c) Each certificate of approval shall be accompanied by a reproduction of... certificate of approval shall also contain the approved quality control plan as specified in § 28.31. ...

  15. 30 CFR 28.21 - Certificates of approval; contents.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PROTECTION FOR TRAILING CABLES IN COAL MINES Approval and Disapproval § 28.21 Certificates of approval... protection for trailing cables. (c) Each certificate of approval shall be accompanied by a reproduction of... certificate of approval shall also contain the approved quality control plan as specified in § 28.31. ...

  16. 30 CFR 28.21 - Certificates of approval; contents.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... PROTECTION FOR TRAILING CABLES IN COAL MINES Approval and Disapproval § 28.21 Certificates of approval... protection for trailing cables. (c) Each certificate of approval shall be accompanied by a reproduction of... certificate of approval shall also contain the approved quality control plan as specified in § 28.31. ...

  17. 30 CFR 28.21 - Certificates of approval; contents.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROTECTION FOR TRAILING CABLES IN COAL MINES Approval and Disapproval § 28.21 Certificates of approval... protection for trailing cables. (c) Each certificate of approval shall be accompanied by a reproduction of... certificate of approval shall also contain the approved quality control plan as specified in § 28.31. ...

  18. System for effecting underwater coupling of optical fiber cables characterized by a novel lateral arm cable capture mechanism

    NASA Astrophysics Data System (ADS)

    Hillenbrand, Christopher F.

    1995-03-01

    A submarine trails one fiber optic cable and an undersea vehicle is controlled by this first cable. A missile/torpedo trails a second cable that is to be coupled to the first cable. The second cable has a segment suspended vertically underwater between a buoyant pod and a sea anchor type buoy. The undersea vehicle, or autonomous undersea vehicle, (AUV) hunts for the pod by conventional homing components, and cable capturing arms on the vehicle direct the cable's movement relative to the vehicle into a pod mating position that achieves optical coupling of the two cables. In one embodiment two arms are pivotably mounted to the vehicle's sides so one arm captures the suspended cable segment directing it into a slot so a male socket in the underside of the pod mates with a female socket in the slot. Another embodiment accomplishes the same result with a device in which the arms are formed as the off-shoots of a forked cable pickup device in the nose of the AUV.

  19. Thermal overload characteristics of extruded dielectric cables: Final report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dima, A.; Katz, C.; Eager, G.S. Jr.

    1988-06-01

    This report addresses characteristics of thermoset extruded dielectric power cables in the 15--35 kV class, operated under thermal overload conditions. It presents a methodical study to determine the suitability of extruded type cable for operation at elevated temperatures. The results provide utilities with knowledge on the behavior of thermoset insulated cables at temperatures in the 130 to 175/degree/C conductor temperature range. Present industry specifications recommend a maximum emergency conductor temperature of 130/degree/C. The suitability of this temperature and the time it is to be maintained had been questioned. The present report indicates that crosslinked polyethylene and ethylene propylene insulated cable,more » both new and service aged, are suitable for emergency operation during extended periods at 130/degree/C. When these cables are provided with polyvinyl chloride jackets, long term exposure to temperatures greater than 130/degree/C can adversely affect the integrity of the jacket. Investigations on new cables were performed on short samples in ovens and on long samples in simulated ducts in the laboratory and in a typical utility duct bank. Investigations on cables recovered from service were performed in the laboratory with the cables installed in simulated ducts. 10 refs., 49 figs., 73 tabs.« less

  20. 30 CFR 28.4 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... MINING PRODUCTS FUSES FOR USE WITH DIRECT CURRENT IN PROVIDING SHORT-CIRCUIT PROTECTION FOR TRAILING... provides short-circuit protection for trailing cables in coal mines by interrupting an excessive current in...

  1. 30 CFR 28.2 - Approved fuses.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... MINING PRODUCTS FUSES FOR USE WITH DIRECT CURRENT IN PROVIDING SHORT-CIRCUIT PROTECTION FOR TRAILING...-circuit protection for trailing cables in coal mines only where such fuses are: (1) The same in all...

  2. 30 CFR 28.10 - Application procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... TRAILING CABLES IN COAL MINES Application for Approval § 28.10 Application procedures. (a) Each applicant seeking approval of a fuse for use with direct current in providing short-circuit protection for trailing...

  3. 30 CFR 75.600-1 - Approved cables; flame resistance.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Approved cables; flame resistance. 75.600-1 Section 75.600-1 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Trailing Cables § 75.600-1 Approved...

  4. Disrupting mitochondrial Ca2+ homeostasis causes tumor-selective TRAIL sensitization through mitochondrial network abnormalities.

    PubMed

    Ohshima, Yohei; Takata, Natsuhiko; Suzuki-Karasaki, Miki; Yoshida, Yukihiro; Tokuhashi, Yasuaki; Suzuki-Karasaki, Yoshihiro

    2017-10-01

    The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has emerged as a promising anticancer agent with high tumor-selective cytotoxicity. The congenital and acquired resistance of some cancer types including malignant melanoma and osteosarcoma impede the current TRAIL therapy of these cancers. Since fine tuning of the intracellular Ca2+ level is essential for cell function and survival, Ca2+ dynamics could be a promising target for cancer treatment. Recently, we demonstrated that mitochondrial Ca2+ removal increased TRAIL efficacy toward malignant melanoma and osteosarcoma cells. Here we report that mitochondrial Ca2+ overload leads to tumor-selective sensitization to TRAIL cytotoxicity. Treatment with the mitochondrial Na+/Ca2+ exchanger inhibitor CGP-37157 and oxidative phosphorylation inhibitor antimycin A and FCCP resulted in a rapid and persistent mitochondrial Ca2+ rise. These agents also increased TRAIL sensitivity in a tumor-selective manner with a switching from apoptosis to a nonapoptotic cell death. Moreover, we found that mitochondrial Ca2+ overload led to increased mitochondrial fragmentation, while mitochondrial Ca2+ removal resulted in mitochondrial hyperfusion. Regardless of their reciprocal actions on the mitochondrial dynamics, both interventions commonly exacerbated TRAIL-induced mitochondrial network abnormalities. These results expand our previous study and suggest that an appropriate level of mitochondrial Ca2+ is essential for maintaining the mitochondrial dynamics and the survival of these cells. Thus, disturbing mitochondrial Ca2+ homeostasis may serve as a promising approach to overcome the TRAIL resistance of these cancers with minimally compromising the tumor-selectivity.

  5. Measurement of the temperature distribution inside the power cable using distributed temperature system

    NASA Astrophysics Data System (ADS)

    Jaros, Jakub; Liner, Andrej; Papes, Martin; Vasinek, Vladimir; Mach, Veleslav; Hruby, David; Kajnar, Tomas; Perecar, Frantisek

    2015-01-01

    Nowadays, the power cables are manufactured to fulfill the following condition - the highest allowable temperature of the cable during normal operation and the maximum allowable temperature at short circuit conditions cannot exceed the condition of the maximum allowable internal temperature. The distribution of the electric current through the conductor leads to the increase of the amplitude of electrons in the crystal lattice of the cables material. The consequence of this phenomenon is the increase of friction and the increase of collisions between particles inside the material, which causes the temperature increase of the carrying elements. The temperature increase is unwanted phenomena, because it is causing losses. In extreme cases, the long-term overload leads to the cable damaging or fire. This paper deals with the temperature distribution measurement inside the power cables using distributed temperature system. With cooperation with Kabex company, the tube containing optical fibers was installed into the center of power cables. These fibers, except telecommunications purposes, can be also used as sensors in measurements carrying out with distributed temperature system. These systems use the optical fiber as a sensor and allow the continual measurement of the temperature along the whole cable in real time with spatial resolution 1 m. DTS systems are successfully deployed in temperature measurement applications in industry areas yet. These areas include construction, drainage, hot water etc. Their advantages are low cost, resistance to electromagnetic radiation and the possibility of real time monitoring at the distance of 8 km. The location of the optical fiber in the center of the power cable allows the measurement of internal distribution of the temperature during overloading the cable. This measurement method can be also used for prediction of short-circuit and its exact location.

  6. 30 CFR 18.35 - Portable (trailing) cables and cords.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Construction... used to conduct electrical energy to face equipment shall conform to the following: (1) Have each conductor of a current-carrying capacity consistent with the Insulated Power Cable Engineers Association...

  7. 30 CFR 18.35 - Portable (trailing) cables and cords.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Construction... used to conduct electrical energy to face equipment shall conform to the following: (1) Have each conductor of a current-carrying capacity consistent with the Insulated Power Cable Engineers Association...

  8. 30 CFR 18.35 - Portable (trailing) cables and cords.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Construction... used to conduct electrical energy to face equipment shall conform to the following: (1) Have each conductor of a current-carrying capacity consistent with the Insulated Power Cable Engineers Association...

  9. 30 CFR 18.35 - Portable (trailing) cables and cords.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Construction... used to conduct electrical energy to face equipment shall conform to the following: (1) Have each conductor of a current-carrying capacity consistent with the Insulated Power Cable Engineers Association...

  10. 4. PACK TRAIN WAITING TO BE UNLOADED AT FOOT OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. PACK TRAIN WAITING TO BE UNLOADED AT FOOT OF YAKI TRAIL. APPROXIMATELY TWO-AND-ONE-HALF TONS OF STEEL ON ANIMALS SHOWN. NOTE COIL OF 1-1/2' WIND CABLE IN FOREGROUND. - Kaibab Trail Suspension Bridge, Spanning Colorado River, Grand Canyon, Coconino County, AZ

  11. 30 CFR 75.516 - Power wires; support.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Electrical Equipment-General § 75.516 Power wires; support. [Statutory Provision] All power wires (except trailing cables on mobile equipment, specially designed cables... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Power wires; support. 75.516 Section 75.516...

  12. 30 CFR 75.516 - Power wires; support.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Electrical Equipment-General § 75.516 Power wires; support. [Statutory Provision] All power wires (except trailing cables on mobile equipment, specially designed cables... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Power wires; support. 75.516 Section 75.516...

  13. 30 CFR 75.516 - Power wires; support.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Electrical Equipment-General § 75.516 Power wires; support. [Statutory Provision] All power wires (except trailing cables on mobile equipment, specially designed cables... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Power wires; support. 75.516 Section 75.516...

  14. 30 CFR 75.516 - Power wires; support.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Power wires; support. 75.516 Section 75.516... MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Electrical Equipment-General § 75.516 Power wires; support. [Statutory Provision] All power wires (except trailing cables on mobile equipment, specially designed cables...

  15. 30 CFR 75.516 - Power wires; support.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Power wires; support. 75.516 Section 75.516... MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Electrical Equipment-General § 75.516 Power wires; support. [Statutory Provision] All power wires (except trailing cables on mobile equipment, specially designed cables...

  16. 30 CFR 75.703-3 - Approved methods of grounding offtrack mobile, portable and stationary direct-current machines.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... separate grounding conductor located within the trailing cable of mobile and portable equipment and... conductor located within the direct-current power cable feeding stationary equipment and connected between... ground conductor connected between stationary equipment and the direct-current grounding medium; or, (d...

  17. 30 CFR 75.703-3 - Approved methods of grounding offtrack mobile, portable and stationary direct-current machines.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... separate grounding conductor located within the trailing cable of mobile and portable equipment and... conductor located within the direct-current power cable feeding stationary equipment and connected between... ground conductor connected between stationary equipment and the direct-current grounding medium; or, (d...

  18. 30 CFR 75.703-3 - Approved methods of grounding offtrack mobile, portable and stationary direct-current machines.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... separate grounding conductor located within the trailing cable of mobile and portable equipment and... conductor located within the direct-current power cable feeding stationary equipment and connected between... ground conductor connected between stationary equipment and the direct-current grounding medium; or, (d...

  19. 30 CFR 75.703-3 - Approved methods of grounding offtrack mobile, portable and stationary direct-current machines.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... separate grounding conductor located within the trailing cable of mobile and portable equipment and... conductor located within the direct-current power cable feeding stationary equipment and connected between... ground conductor connected between stationary equipment and the direct-current grounding medium; or, (d...

  20. 30 CFR 75.703-3 - Approved methods of grounding offtrack mobile, portable and stationary direct-current machines.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... separate grounding conductor located within the trailing cable of mobile and portable equipment and... conductor located within the direct-current power cable feeding stationary equipment and connected between... ground conductor connected between stationary equipment and the direct-current grounding medium; or, (d...

  1. Failure of the Trailing Umbilical System Disconnect Actuator on the International Space Station

    NASA Technical Reports Server (NTRS)

    Gilmore, Adam; Schmitt, Chris; Merritt, Laura; Bolton, V. J.

    2008-01-01

    In December of 2005, one of two trailing umbilical cables used on the International Space Station (ISS) Mobile Transporter (MT) was inadvertently severed by an internal cutter system designed to free a snagged cable or jammed reel while transporting hazardous payloads. The mechanism s intended means of actuation is electrical; however, troubleshooting revealed a mechanical actuation occurred. The investigation of the failed component revealed several lessons learned in developing hardware requirements, understanding and following the rationale behind the requirements throughout the design life cycle, understanding the impacts of gaps and tolerances in a mechanism, and the importance of identifying critical steps during assembly.

  2. Failure of the Trailing Umbilical System Disconnect Actuator on the International Space Station

    NASA Technical Reports Server (NTRS)

    Gilmore, Adam; Schmitt, Chris; Merritt, Laura; Bolton, V. J.

    2008-01-01

    In December of 2005, one of two trailing umbilical cables used on the International Space Station (ISS) Mobile Transporter (MT) was inadvertently severed by an internal cutter system designed to free a snagged cable or jammed reel while transporting hazardous payloads. The mechanism s intended means of actuation is electrical; however, troubleshooting revealed a mechanical actuation occurred. The investigation of the failed component revealed several lessons learned in developing hardware requirements, understanding and following the rationale behind the requirements throughout the design life cycle, understanding the impacts of gaps and tolerances in a mechanism, and the importance of identifying critical steps during assembly

  3. Simultaneous use of several monitoring techniques to measure visitor load, spatio-temporal distribution and social characteristics of tourists - a case study of a cable car area in the Carpathian Mountains, Tatra National Park

    NASA Astrophysics Data System (ADS)

    Taczanowska, Karolina; Zięba, Antoni; Brandenburg, Christiane; Muhar, Andreas; Preisel, Hemma; Hibner, Joanna; Latosinska, Barbara; Benítez, Rafael; Bolós, Vicente; Toca-Herrera, José L.; Ziobrowski, Szymon

    2017-04-01

    Visitor monitoring is an integrate part of the effective management of recreational and protected areas. Comprehensive information concerning volume of tourist traffic, spatial-temporal distribution of visitors in a leisure setting as well as visitor socio-demographic characteristics may support understanding human behaviour and the ongoing natural processes (trail deterioration, erosion, impact on flora and fauna). Especially, vulnerable areas that in the same time serve as tourist attractions need to be carefully investigated. One of such areas is Kasprowy Wierch (1987 m.a.s.l.) - a popular cable car destination located in the Carpathian Mountains, Tatra National Park, Poland / Slovakia. The aim of this study was to define the overall visitor load and to understand visitor behaviour in the proximity of the upper cable car station at Kasprowy Wierch. The main focus of this presentation is the comparison of the used monitoring techniques and exposing the benefit of their simultaneous application. Visitor monitoring campaign was carried out in the study area in the summer season 2014. The following data collection techniques were simultaneously applied: 1) automatic counting (Eco-Counter pyroelectric sensors), 2) manual counting; 3) on-site interviews combined with trip diaries and visitor observation 4) GPS-tracking 5) registry of cable car tickets 6) registry of entries to the national park (TPN). Between 26.06.2014 and 30.09.2014 at 7 locations a continuous automatic counting of visitors was done using pyroelectric sensors (Eco-Counter). Additionally, on 18 sampling days at 12 locations direct observations (manual counting) of visitor flows was carried out. During the sampling days tourists were interviewed in the field using structured questionnaires (PAPI survey technique, N = 2639). Survey was combined with a documentation of visitors' trip itineraries via GPS-loggers and map sketches. Totally 1250 GPS-tracks of visitors and 1351 map sketches have been collected. Between July and September 2014 a total number of 292 493 visitors moving towards Kasprowy Wierch (KW) were registered in the cable car and on recreational trails leading to KW. 80% of people used cable car, whereas 20% were using hiking trails to get to the summit and back. Cable car users with return tickets were the most numerous tourist group in the Kasprowy Wierch area. Between July and September 2014 the share of specific ticket types among cable car users was as follows: return tickets „up & down" = 59%, on-way tickets „up" = 26%, on-way tickets „down" = 15%. In the summer season 2014 on average 3179 visitors per day arrived to KW area. The maximum tourist traffic was observed in August 2014 where daily number of visitors exceded 7000. Two most intensively used path segments were located next to the upper cable car station (cable car station - Sucha Pass; cable car station - meteorological station/summit of KW). Third most heavily used path segment was located between Sucha Pass and the summit of Beskid. Visitor load at path segments located next to the cable car station was on average 5-10 times higher than the visitor load at other hiking trails in the area (e.g. trail linking Kasprowy Wierch and Czerwone Wierchy or Liliowe Pass and Świnica). Each monitoring technique allows gaining different type of information. Simultaneous use of several data collection methods has an additional added value when trying to understand tourist behaviour in the studied area. The results can be used as a basis for further investigation concerning environmental and social impacts in the Kasprowy Wierch area and may assist management of the Tatra National Park.

  4. Review of fire test methods and incident data for portable electric cables in underground coal mines

    NASA Astrophysics Data System (ADS)

    Braun, E.

    1981-06-01

    Electrically powered underground coal mining machinery is connected to a load center or distribution box by electric cables. The connecting cables used on mobile machines are required to meet fire performance requirements defined in the Code of Federal Regulations. This report reviews Mine Safety and Health Administration's (MSHA) current test method and compares it to British practices. Incident data for fires caused by trailing cable failures and splice failures were also reviewed. It was found that the MSHA test method is more severe than the British but that neither evaluated grouped cable fire performance. The incident data indicated that the grouped configuration of cables on a reel accounted for a majority of the fires since 1970.

  5. Wireline tool cable head overload apparatus

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Roessler, D.E.

    1990-05-29

    This patent describes a cable head adapted to support a sonde in a well borehole. It comprises: an upper end assembly adapted for connection with a cable extending into a well borehole; a lower end assembly adapted for connection to a sonde to be supported by the cable in the well borehole; yieldable means joining the upper and lower assemblies together in a fixed but yieldable relationship wherein a controllable and variable load is imparted to the cable there above during movement and variations in load on the cable are maintained within specified limits; the yieldable means further including deadmore » weight adjustable means notwithstanding variations in the dead weight of the load, and the yieldable means includes resilient means permitting movements within a desired range dependent on the adjustment thereof and bracketing a selected relative position of the upper and lower end assemblies; and an electrical contact.« less

  6. Turbine-Driven Pipe-Cleaning Brush

    NASA Technical Reports Server (NTRS)

    Werlink, Rudy J.; Rowell, David E.

    1994-01-01

    Simple pipe-cleaning device includes small turbine wheel axially connected, by standoff, to circular brush. Turbine wheel turns on hub bearing attached to end of upstream cable. Turbine-and-brush assembly inserted in pipe with cable trailing upstream and brush facing downstream. Water or cleaning solution pumped through pipe. Cable held at upstream end, so it holds turbine and brush in pipe at location to be cleaned. Flow in pipe turns turbine, which turns wheel, producing desired cleaning action. In addition to brushing action, device provides even mixing of cleaning solution in pipe.

  7. Manned spacecraft electrical fire safety

    NASA Technical Reports Server (NTRS)

    Wardell, A. W.

    1971-01-01

    The fire hazards created in spacecraft compartments by malfunction of electrical wiring are described. The tests for electrical wire/cable current overload flammability are presented. The application of electrical and material technologies to the reduction of fire hazards in spacecraft are examined.

  8. 30 CFR 75.825 - Power centers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., de-energizes input to all power transformers. (b) Trailing cable disconnecting device. In addition to... be equipped with a grounding stick to be used prior to performing electrical work to assure that high...

  9. 30 CFR 28.24 - Revocation of certificates of approval.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... PROTECTION FOR TRAILING CABLES IN COAL MINES Approval and Disapproval § 28.24 Revocation of certificates of... failure to maintain or cause to be maintained the quality control requirements of the certificate of...

  10. 30 CFR 28.24 - Revocation of certificates of approval.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROTECTION FOR TRAILING CABLES IN COAL MINES Approval and Disapproval § 28.24 Revocation of certificates of... failure to maintain or cause to be maintained the quality control requirements of the certificate of...

  11. 30 CFR 28.24 - Revocation of certificates of approval.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PROTECTION FOR TRAILING CABLES IN COAL MINES Approval and Disapproval § 28.24 Revocation of certificates of... failure to maintain or cause to be maintained the quality control requirements of the certificate of...

  12. 30 CFR 28.24 - Revocation of certificates of approval.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PROTECTION FOR TRAILING CABLES IN COAL MINES Approval and Disapproval § 28.24 Revocation of certificates of... failure to maintain or cause to be maintained the quality control requirements of the certificate of...

  13. 30 CFR 28.10 - Application procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Labor, Mine Safety and Health Administration, Approval and Certification Center, 765 Technology Drive... Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND... TRAILING CABLES IN COAL MINES Application for Approval § 28.10 Application procedures. (a) Each applicant...

  14. 30 CFR 28.10 - Application procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Labor, Mine Safety and Health Administration, Approval and Certification Center, 765 Technology Drive... Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND... TRAILING CABLES IN COAL MINES Application for Approval § 28.10 Application procedures. (a) Each applicant...

  15. 30 CFR 28.10 - Application procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Labor, Mine Safety and Health Administration, Approval and Certification Center, 765 Technology Drive... Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND... TRAILING CABLES IN COAL MINES Application for Approval § 28.10 Application procedures. (a) Each applicant...

  16. 30 CFR 28.10 - Application procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Labor, Mine Safety and Health Administration, Approval and Certification Center, 765 Technology Drive... Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND... TRAILING CABLES IN COAL MINES Application for Approval § 28.10 Application procedures. (a) Each applicant...

  17. 30 CFR 57.12027 - Grounding mobile equipment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Grounding mobile equipment. 57.12027 Section 57... Surface and Underground § 57.12027 Grounding mobile equipment. Frame grounding or equivalent protection shall be provided for mobile equipment powered through trailing cables. ...

  18. Dynamic characteristics of a 20 kHz resonant power system - Fault identification and fault recovery

    NASA Technical Reports Server (NTRS)

    Wasynczuk, O.

    1988-01-01

    A detailed simulation of a dc inductor resonant driver and receiver is used to demonstrate the transient characteristics of a 20 kHz resonant power system during fault and overload conditions. The simulated system consists of a dc inductor resonant inverter (driver), a 50-meter transmission cable, and a dc inductor resonant receiver load. Of particular interest are the driver and receiver performance during fault and overload conditions and on the recovery characteristics following removal of the fault. The information gained from these studies sets the stage for further work in fault identification and autonomous power system control.

  19. 30 CFR 28.40 - Construction and performance requirements; general.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... Department of Labor, Mine Safety and Health Administration, Approval and Certification Center, 765 Technology...; general. 28.40 Section 28.40 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR...-CIRCUIT PROTECTION FOR TRAILING CABLES IN COAL MINES Construction, Performance, and Testing Requirements...

  20. 30 CFR 28.40 - Construction and performance requirements; general.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... Department of Labor, Mine Safety and Health Administration, Approval and Certification Center, 765 Technology...; general. 28.40 Section 28.40 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR...-CIRCUIT PROTECTION FOR TRAILING CABLES IN COAL MINES Construction, Performance, and Testing Requirements...

  1. 30 CFR 28.40 - Construction and performance requirements; general.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... Department of Labor, Mine Safety and Health Administration, Approval and Certification Center, 765 Technology...; general. 28.40 Section 28.40 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR...-CIRCUIT PROTECTION FOR TRAILING CABLES IN COAL MINES Construction, Performance, and Testing Requirements...

  2. 30 CFR 28.40 - Construction and performance requirements; general.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... Department of Labor, Mine Safety and Health Administration, Approval and Certification Center, 765 Technology...; general. 28.40 Section 28.40 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR...-CIRCUIT PROTECTION FOR TRAILING CABLES IN COAL MINES Construction, Performance, and Testing Requirements...

  3. 30 CFR 28.32 - Proposed quality control plans; approval by MSHA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Proposed quality control plans; approval by...-CIRCUIT PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.32 Proposed quality control plans; approval by MSHA. (a) Each proposed quality control plan submitted in accordance with this...

  4. 30 CFR 28.30 - Quality control plans; filing requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Quality control plans; filing requirements. 28... PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.30 Quality control plans; filing... part, each applicant shall file with MSHA a proposed quality control plan which shall be designed to...

  5. 30 CFR 28.30 - Quality control plans; filing requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Quality control plans; filing requirements. 28... PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.30 Quality control plans; filing... part, each applicant shall file with MSHA a proposed quality control plan which shall be designed to...

  6. 30 CFR 28.30 - Quality control plans; filing requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.30 Quality control plans; filing... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Quality control plans; filing requirements. 28... part, each applicant shall file with MSHA a proposed quality control plan which shall be designed to...

  7. 30 CFR 28.32 - Proposed quality control plans; approval by MSHA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...-CIRCUIT PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.32 Proposed quality control plans; approval by MSHA. (a) Each proposed quality control plan submitted in accordance with this... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Proposed quality control plans; approval by...

  8. 30 CFR 28.32 - Proposed quality control plans; approval by MSHA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...-CIRCUIT PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.32 Proposed quality control plans; approval by MSHA. (a) Each proposed quality control plan submitted in accordance with this... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Proposed quality control plans; approval by...

  9. 30 CFR 28.30 - Quality control plans; filing requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.30 Quality control plans; filing... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Quality control plans; filing requirements. 28... part, each applicant shall file with MSHA a proposed quality control plan which shall be designed to...

  10. 30 CFR 28.30 - Quality control plans; filing requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.30 Quality control plans; filing... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Quality control plans; filing requirements. 28... part, each applicant shall file with MSHA a proposed quality control plan which shall be designed to...

  11. 30 CFR 28.32 - Proposed quality control plans; approval by MSHA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...-CIRCUIT PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.32 Proposed quality control plans; approval by MSHA. (a) Each proposed quality control plan submitted in accordance with this... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Proposed quality control plans; approval by...

  12. 30 CFR 28.31 - Quality control plans; contents.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28.31 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING... PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.31 Quality control plans; contents. (a... Specification MIL-F-15160D is available for examination at the U.S. Department of Labor, Mine Safety and Health...

  13. 30 CFR 28.31 - Quality control plans; contents.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28.31 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING... PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.31 Quality control plans; contents. (a... Specification MIL-F-15160D is available for examination at the U.S. Department of Labor, Mine Safety and Health...

  14. 30 CFR 28.31 - Quality control plans; contents.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28.31 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING... PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.31 Quality control plans; contents. (a... Specification MIL-F-15160D is available for examination at the U.S. Department of Labor, Mine Safety and Health...

  15. 30 CFR 28.31 - Quality control plans; contents.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28.31 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING... PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.31 Quality control plans; contents. (a... Specification MIL-F-15160D is available for examination at the U.S. Department of Labor, Mine Safety and Health...

  16. 30 CFR 28.31 - Quality control plans; contents.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Quality control plans; contents. 28.31 Section... PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.31 Quality control plans; contents. (a) Each quality control plan shall contain provisions for the management of quality, including: (1...

  17. 75 FR 41529 - Petitions for Modification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-16

    ... number'' on the subject line, by any of the following methods: 1. Electronic Mail: Standards-Petitions... permissible pump trailing cables will not be smaller than 10 American Wire Gauge (AWG); (4) all circuit... will have an instantaneous trip unit calibrated to trip at 70 percent of phase-to-phase short-circuit...

  18. A procedure for analysis of guyline tension.

    Treesearch

    Ward W. Carson; Jens E. Jorgensen; Stephen E. Reutebuch; William J. Bramwell

    1982-01-01

    Most cable logging operations use a spar held in place near the landing by a system of guylines and anchors. Safety and economic considerations require that overloads be avoided and that the spar remain stable. This paper presents a procedure and a computer program to estimate the guyline and anchor loads on a particular system configuration by a specific set of...

  19. 30 CFR 77.804 - High-voltage trailing cables; minimum design requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... equipped with metallic shields around each power conductor with one or more ground conductors having a total cross-sectional area of not less than one-half the power conductor, and with an insulated conductor for the ground continuity check circuit. External ground check conductors may be used if they are...

  20. 30 CFR 28.32 - Proposed quality control plans; approval by MSHA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... subpart shall be reviewed by MSHA to determine its effectiveness in insuring the quality of short-circuit... TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS FUSES FOR USE WITH DIRECT CURRENT IN PROVIDING SHORT-CIRCUIT PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.32 Proposed quality control...

  1. 76 FR 22148 - Petitions for Modification of Application of Existing Mandatory Safety Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-20

    ..., grounded phase, under-voltage, and ground monitoring protection; (b) the trailing cable short-circuit... activated; (c) the solenoid valves will be connected to the CO monitoring system through PLC programming... surface location, either the CO monitoring room or the security station. Either, two miners on each shift...

  2. 30 CFR 28.4 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Definitions. 28.4 Section 28.4 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS FUSES FOR USE WITH DIRECT CURRENT IN PROVIDING SHORT-CIRCUIT PROTECTION FOR TRAILING CABLES IN COAL MINES General Provisions § 28.4...

  3. 30 CFR 75.831 - Electrical work; troubleshooting and testing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... disconnecting device: (i) Remove the plug from the power receptacle and connect it to the grounding receptacle... coupler is used as a disconnecting device: (i) Remove the plug from the power receptacle and connect it to...) or (2): (1) If a trailing cable disconnecting switch is provided: (i) Open and ground the power...

  4. Combating information overload: a six-month pilot evaluation of a knowledge management system in general practice.

    PubMed Central

    O'Brien, C; Cambouropoulos, P

    2000-01-01

    A six-month prospective study was conducted on the usefulness and usability of a representative electronic knowledge management tool, the WAX Active Library, for 19 general practitioners (GPs) evaluated using questionnaires and audit trail data. The number of pages accessed was highest in the final two months, when over half of the access trails were completed within 40 seconds. Most GPs rated the system as easy to learn, fast to use, and preferable to paper for providing information during consultations. Such tools could provide a medium for the activities of knowledge officers, help demand management, and promote sharing of information within primary care groups and across NHSnet or the Internet. PMID:10962792

  5. 30 CFR 28.33 - Quality control test methods, equipment, and records; review by MSHA; revocation of approval.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Quality control test methods, equipment, and... USE WITH DIRECT CURRENT IN PROVIDING SHORT-CIRCUIT PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.33 Quality control test methods, equipment, and records; review by MSHA; revocation...

  6. 30 CFR 28.33 - Quality control test methods, equipment, and records; review by MSHA; revocation of approval.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Quality control test methods, equipment, and... USE WITH DIRECT CURRENT IN PROVIDING SHORT-CIRCUIT PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.33 Quality control test methods, equipment, and records; review by MSHA; revocation...

  7. 30 CFR 28.33 - Quality control test methods, equipment, and records; review by MSHA; revocation of approval.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Quality control test methods, equipment, and... USE WITH DIRECT CURRENT IN PROVIDING SHORT-CIRCUIT PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.33 Quality control test methods, equipment, and records; review by MSHA; revocation...

  8. 30 CFR 28.33 - Quality control test methods, equipment, and records; review by MSHA; revocation of approval.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Quality control test methods, equipment, and... USE WITH DIRECT CURRENT IN PROVIDING SHORT-CIRCUIT PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.33 Quality control test methods, equipment, and records; review by MSHA; revocation...

  9. 30 CFR 28.33 - Quality control test methods, equipment, and records; review by MSHA; revocation of approval.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Quality control test methods, equipment, and... USE WITH DIRECT CURRENT IN PROVIDING SHORT-CIRCUIT PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.33 Quality control test methods, equipment, and records; review by MSHA; revocation...

  10. 46 CFR 189.35-9 - Plans.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... withstand and operate in excess of the breaking strength of the strongest section or wire to be used in any... application of a load equal to the nominal breaking strength of the strongest section or wire rope to be used... or for trailing objects, where the wire rope or cable is payed out beneath the surface and becomes...

  11. 46 CFR 189.35-9 - Plans.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... withstand and operate in excess of the breaking strength of the strongest section or wire to be used in any... application of a load equal to the nominal breaking strength of the strongest section or wire rope to be used... or for trailing objects, where the wire rope or cable is payed out beneath the surface and becomes...

  12. 46 CFR 189.35-9 - Plans.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... withstand and operate in excess of the breaking strength of the strongest section or wire to be used in any... application of a load equal to the nominal breaking strength of the strongest section or wire rope to be used... or for trailing objects, where the wire rope or cable is payed out beneath the surface and becomes...

  13. Shrink-Fit Solderable Inserts Seal Hermetically

    NASA Technical Reports Server (NTRS)

    Croucher, William C.

    1992-01-01

    Shrink-fit stainless-steel insert in aluminum equipment housing allows electrical connectors to be replaced by soldering, without degrading hermeticity of housing or connector. Welding could destroy electrostatic-sensitive components and harm housing and internal cables. Steel insert avoids problems because connector soldered directly to it rather than welded to housing. Seals between flange and housing, and between connector and flange resistant to leaks, even after mechanical overloading and thermal shocking.

  14. Method of Calculating the Correction Factors for Cable Dimensioning in Smart Grids

    NASA Astrophysics Data System (ADS)

    Simutkin, M.; Tuzikova, V.; Tlusty, J.; Tulsky, V.; Muller, Z.

    2017-04-01

    One of the main causes of overloading electrical equipment by currents of higher harmonics is the great increasing of a number of non-linear electricity power consumers. Non-sinusoidal voltages and currents affect the operation of electrical equipment, reducing its lifetime, increases the voltage and power losses in the network, reducing its capacity. There are standards that respects emissions amount of higher harmonics current that cannot provide interference limit for a safe level in power grid. The article presents a method for determining a correction factor to the long-term allowable current of the cable, which allows for this influence. Using mathematical models in the software Elcut, it was described thermal processes in the cable in case the flow of non-sinusoidal current. Developed in the article theoretical principles, methods, mathematical models allow us to calculate the correction factor to account for the effect of higher harmonics in the current spectrum for network equipment in any type of non-linear load.

  15. Measuring low rates of erosion from forest fuel reduction operations

    Treesearch

    William J. Elliot; Ina Sue Miller

    2004-01-01

    A study was carried out to evaluate three methods for measuring low levels of hillside soil erosion associated with forest fuel management activities, and to measure erosion from cable logging and skid trails. The tipping bucket device with a sediment basin appears to be a better tool for this application than silt fences or rillmeter analysis. The greatest erosion...

  16. Ionizing radiation effects on ISS ePTFE jacketed cable assembly

    NASA Astrophysics Data System (ADS)

    Koontz, S. L.; Golden, J. L.; Lorenz, M. J.; Pedley, M. D.

    2003-09-01

    Polytetrafluoroethylene (PTFE), which is susceptible to embrittlement by ionizing radiation, is used as a primary material in the Mobile Transporter's (MT) Trailing Umbilical System (TUS) cable on the International Space Station (ISS). The TUS cable provides power and data service between the ISS truss and the MT. The TUS cable is normally stowed in an uptake reel and is fed out to follow the MT as it moves along rails on the ISS truss structure. For reliable electrical and mechanical performance, TUS cable polymeric materials must be capable of >3.5% elongation without cracking or breaking. The MT TUS cable operating temperature on ISS is expected to range between -100°C and +130°C. The on-orbit functional life requirement for the MT TUS cable is 10 years. Analysis and testing were performed to verify that the MT TUS cable would be able to meet full-life mechanical and electrical performance requirements, despite progressive embrittlement by the natural ionizing radiation environment. Energetic radiation belt electrons (trapped electrons) are the principal contributor to TUS cable radiation dose. TUS cable specimens were irradiated, in vacuum, with both energetic electrons and gamma rays. Electron beam energy was chosen to minimize charging effects on the non-conductive ePTFE (expanded PTFE) targets. Tensile testing was then performed, over the expected range of operating temperatures, as a function of radiation dose. When compared to the expected in-flight radiation dose/depth profile, atomic oxygen (AO) erosion of the radiation damaged TUS cable jacket surfaces is more rapid than the development of radiation induced embrittlement of the same surfaces. Additionally, the layered construction of the jacket prevents crack growth propagation, leaving the inner layer material compliant with the design elongation requirements. As a result, the TUS cable insulation design was verified to meet performance life requirements.

  17. Investigation of HP Turbine Blade Failure in a Military Turbofan Engine

    NASA Astrophysics Data System (ADS)

    Mishra, R. K.; Thomas, Johny; Srinivasan, K.; Nandi, Vaishakhi; Bhatt, R. Raghavendra

    2017-04-01

    Failure of a high pressure (HP) turbine blade in a military turbofan engine is investigated to determine the root cause of failure. Forensic and metallurgical investigations are carried out on the affected blades. The loss of coating and the presence of heavily oxidized intergranular fracture features including substrate material aging and airfoil curling in the trailing edge of a representative blade indicate that the coating is not providing adequate oxidation protection and the blade material substrate is not suitable for the application at hand. Coating spallation followed by substrate oxidation and aging leading to intergranular cracking and localized trailing edge curling is the root cause of the blade failure. The remaining portion of the blade fracture surface showed ductile overload features in the final failure. The damage observed in downstream components is due to secondary effects.

  18. Predicting bunching costs for the Radio Horse 9 winch

    Treesearch

    Chris B. LeDoux; Bruce W. Kling; Patrice A. Harou; Patrice A. Harou

    1987-01-01

    Data from field studies and a prebunching cost simulator have been assembled and converted into a general equation that can be used to estimate the prebunching cost of the Radio Horse 9 winch. The methods can be used to estimate prebunching cost for bunching under the skyline corridor for swinging with cable systems, for bunching to skid trail edge to be picked up by a...

  19. The Chevron Foil Thrust Bearing: Improved Performance Through Passive Thermal Management and Effective Lubricant Mixing

    NASA Technical Reports Server (NTRS)

    Bruckner, Robert

    2013-01-01

    An improved foil thrust bearing is described that eliminates or reduces the need for forced cooling of the bearing foils while at the same time improves the load capacity of the bearing, enhances damping, provides overload tolerance, and eliminates the high speed load capacity drop-off that plagues the current state of the art. The performance improvement demonstrated by the chevron foil thrust bearing stems from a novel trailing edge shape that splays the hot lubricant in the thin film radially, thus preventing hot lubricant carry-over into the ensuing bearing sector. Additionally, the chevron shaped trailing edge induces vortical mixing of the hot lubricant with the gas that is naturally resident within the inter-pad region of a foil thrust bearing. The elimination of hot gas carry-over in combination with the enhanced mixing has enabled a completely passive thermally managed foil bearing design. Laboratory testing at NASA has confirmed the original analysis and reduced this concept to practice.

  20. Next-generation optical wireless communications for data centers

    NASA Astrophysics Data System (ADS)

    Arnon, Shlomi

    2015-01-01

    Data centers collect and process information with a capacity that has been increasing from year to year at an almost exponential pace. Traditional fiber/cable data center network interconnections suffer from bandwidth overload, as well as flexibility and scalability issues. Therefore, a technology-shift from the fiber and cable to wireless has already been initiated in order to meet the required data-rate, flexibility and scalability demands for next-generation data center network interconnects. In addition, the shift to wireless reduces the volume allocated to the cabling/fiber and increases the cooling efficiency. Optical wireless communication (OWC), or free space optics (FSO), is one of the most effective wireless technologies that could be used in future data centers and could provide ultra-high capacity, very high cyber security and minimum latency, due to the low index of refraction of air in comparison to fiber technologies. In this paper we review the main concepts and configurations for next generation OWC for data centers. Two families of technologies are reviewed: the first technology regards interconnects between rack units in the same rack and the second technology regards the data center network that connects the server top of rack (TOR) to the switch. A comparison between different network technologies is presented.

  1. The efficacy and safety of lixivaptan in outpatients with heart failure and volume overload: results of a multicentre, randomized, double-blind, placebo-controlled, parallel-group study.

    PubMed

    Ghali, Jalal K; Orlandi, Cesare; Abraham, William T

    2012-06-01

    Volume overload is the dominant feature of decompensated heart failure (HF) and it often results in adverse clinical outcomes. Vasopressin receptor antagonists such as lixivaptan may provide effective volume unloading. This study assessed weight loss after 1 day and 8 weeks of treatment with lixivaptan in outpatients with HF and volume overload. This phase II, 8-week, multicentre, double-blind, parallel-group study randomized participants (2:1) to receive lixivaptan 100 mg or placebo once daily (in addition to standard HF therapy). Body weight and cardiovascular assessments were made at baseline, Day 1 (not cardiovascular), Weeks 1, 2, 4, and 8, and 7 days post-treatment. The Trail-making Test, part B (TMT-B) and the Medical Outcomes Survey 6-item cognitive function scale (MOS-6) were assessed at baseline and Week 4. The study randomized 170 participants (lixivaptan, n = 111; placebo, n = 59). Most (97.1%) were receiving pharmacological therapy for HF at baseline. Demographic characteristics were generally similar between the two groups. Body weight decreased significantly from baseline to Day 1 with lixivaptan vs. placebo (least-square mean change ± standard error: - 0.38 ± 0.08 kg vs. +0.13 ± 0.11 kg; P < 0.001) and at Weeks 1, 2, and 4 (P < 0.01). Cardiovascular changes were generally similar in both groups, though orthopnoea and dyspnoea improved in the lixivaptan group vs. placebo. The TMT-B and MOS-6 showed no significant differences between groups. Lixivaptan was well tolerated-thirst and polyuria occurred more frequently vs. placebo. In outpatients with HF and volume overload, lixivaptan 100 mg once daily, when added to standard therapy, reduced body weight, improved dyspnoea and orthopnoea, and was well tolerated. NCT01055912.

  2. Ae Behavior of Smart Stress Memory Patch after Variable Amplitude Loading

    NASA Astrophysics Data System (ADS)

    Fujino, Y.; Nambu, S.; Enoki, M.

    Recently, the structural health monitoring becomes increasingly great important to assure the ease and safety of our life, and it is required significantly to develop non-destructive evaluation for structures such as bridges and tunnels. Some sacrificed specimens have been developed to evaluate the fatigue damage of structures such as fatigue cycles and residual lifetime, but it can be applied only when the stress history is known beforehand. These fatigue sensors need no cable and can be used at low cost in contrast to strain gage. In previous study, a smart stress memory patch was developed as a new fatigue sensor. The patch can measure simultaneously the maximum stress, stress amplitude and the number of fatigue cycles by crack length measurement and Kaiser effect of Acoustic Emission (AE). The crack growth behavior under constant amplitude (CA) loading has been investigated, and AE behavior also has been evaluated only after CA loading. However, AE characteristics after variable amplitude (VA) loading in service are extremely important. Moreover, it is very important to control AE behavior of the smart patch in order to evaluate the applied stress using Kaiser effect. In this study, fatigue test with single overload was investigated to evaluate its influence. Moreover, effect of crack length and heat treatment on AE behavior was also investigated. Finally, AE behavior of the patch was evaluated after fatigue CA loading with overload or VA loading with log-normal distribution and overload.

  3. Examining physiological responses across different driving maneuvers during an on-road driving task: a pilot study comparing older and younger drivers.

    PubMed

    Koppel, S; Kuo, J; Berecki-Gisolf, J; Boag, R; Hue, Y-X; Charlton, J L

    2015-01-01

    This pilot study aimed to investigate physiological responses during an on-road driving task for older and younger drivers. Five older drivers (mean age = 74.60 years [2.97]) and 5 younger drivers (mean age = 30.00 years [3.08]) completed a series of cognitive assessments (Montreal Cognitive Assessment [MoCA], Mini Mental Status Examination [MMSE]; Trail Making Test [Trails A and Trails B]) and an on-road driving task along a predetermined, standardized urban route in their own vehicle. Driving performance was observed and scored by a single trained observer using a standardized procedure, where driving behaviors (appropriate and inappropriate) were scored for intersection negotiation, lane changing, and merging. During the on-road driving task, participants' heart rate (HR) was monitored with an unobtrusive physiological monitor. Younger drivers performed significantly better on all cognitive assessments compared to older drivers (MoCA: t(8) = 3.882, P <.01; MMSE: t(8) = 2.954, P <.05; Trails A: t(8) = -2.499, P <.05; Trails B: t(8) = -3.262, P <.05). Analyses of participants' performance during the on-road driving task revealed a high level of appropriate overall driving behavior (M = 87%, SD = 7.62, range = 73-95%), including intersection negotiation (M = 89%, SD = 8.37%), lane changing (M = 100%), and merging (M = 53%, SD = 28.28%). The overall proportion of appropriate driving behavior did not significantly differ across age groups (younger drivers: M = 87.6%, SD = 9.04; older drivers: M = 87.0%, SD = 6.96; t(8) = 0.118, P =.91). Although older drivers scored lower than younger drivers on the cognitive assessments, there was no indication of cognitive overload among older drivers based on HR response to the on-road driving task. The results provide preliminary evidence that mild age-related cognitive impairment may not pose a motor vehicle crash hazard for the wider older driver population. To maintain safe mobility of the aging population, further research into the specific crash risk factors in the older driver population is warranted.

  4. STS-121: Discovery Spacewalk Overview Briefing

    NASA Technical Reports Server (NTRS)

    2006-01-01

    The briefing began with the introduction of Tomas Gonzalez-Torres (Lead Extra Vehicular Activity Officer). The spacewalk team included Pierce Sellers (EV-1), Mike Fossum (EV-2) and Mark Kelly (coordinator and pilot). Three new EMU's (space suits) were provided with hardware upgrades (warning systems). The 1st EVA would take place on flight day 5 and would include the exchange of the 3 EMU's. The 1st task was the installation of the blade locker, a device used to prevent severing of cables. The team will also install the Interface Umbilical System (IUS) which is an extension cord for the mobile transporter. EVA-2 task will be to replace the old Trailing Umbilical System (TUS) with a new one.

  5. INTERNATIONAL UNION OF OPERATING ENGINEERS NATIONAL HAZMAT PROGRAM - PORTER-CABLE CIRCULAR SAW OENHP: 2001-04, VERSION A

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Unknown

    2002-01-15

    Florida International University's (FIU) Hemispheric Center for Environmental Technology (HCET) evaluated five saws for their effectiveness in cutting specially prepared fiberglass-reinforced plywood crates. These crates were built as surrogates for crates that presently hold radioactively contaminated glove boxes at the Department of Energy's (DOE) Los Alamos facility. The Porter-Cable circular saw was assessed on August 15-16, 2001 (Porter-Cable No.1 and Porter-Cable No.2, respectively). During the FIU test of efficacy, a team from the Operating Engineers National Hazmat Program (OENHP) evaluated the occupational safety and health issues associated with this technology. The Porter-Cable saw is a straightforward machine for cutting woodmore » of varying thickness. The blade is fully guarded with a fixed upper and a lower retractable guard. The lower guard retracts as the blade engages the work piece. The unit is operated with an on/off guarded trigger switch and is supported with a handgrip mounted near the front of the saw. The saw is equipped with a directional nozzle, which aims sawdust away from the operator and the line of cut. An optional vacuum system, attached to the directional nozzle, is used to remove and collect dust. During the demonstration of Porter-Cable No.1, personal noise sampling indicated that one worker was under and one was at the Occupational Safety and Health Administration's (OSHA) Action Level of 85 decibels (dBA) with time-weighted averages (TWA's) of 82.7 and 84.6 dBA, respectively. During the demonstration of Porter-Cable No.2, however, both workers did exceed the Action Level with TWA's of 89.7 and 90.0 dBA. These data are not entirely representative as they were gathered during a simulation and not at the actual worksite. Additional sampling should be conducted on-site, but the workers should wear hearing protection until it is determined that it is no longer necessary. The total nuisance dust sample for Porter-Cable No.1 was 3.53 milligrams per cubic meter (mg/m{sup 3}), which is lower than the OSHA Permissible Exposure Limit (PEL) of 15 mg/m{sup 3} and the American Conference of Governmental Industrial Hygienists' (ACGIH) Threshold Limit Value (TLV) of 10 mg/m{sup 3}. Porter-Cable No.2's nuisance dust results yielded a value of 22.05 mg/m{sup 3}, which is over the PEL and TLV. The fiber analysis for the first demonstration yielded 12.9 fibers per cubic centimeter (f/cc), which is much higher than the PEL of 1 f/cc. Galson Laboratories considered the fiber analysis for the second demonstration void due to the overloading of dust on the filter. Kickback, the sudden reaction to a pinched blade, is possible with this saw and could cause the saw to lift up and out of the work piece and toward the operator. Proper work position and firm control of the saw minimizes the potential for a sprain or strain. Care needs to be exercised to support the work piece properly and to not force the tool.« less

  6. Extension algorithm for generic low-voltage networks

    NASA Astrophysics Data System (ADS)

    Marwitz, S.; Olk, C.

    2018-02-01

    Distributed energy resources (DERs) are increasingly penetrating the energy system which is driven by climate and sustainability goals. These technologies are mostly connected to low- voltage electrical networks and change the demand and supply situation in these networks. This can cause critical network states. Network topologies vary significantly and depend on several conditions including geography, historical development, network design or number of network connections. In the past, only some of these aspects were taken into account when estimating the network investment needs for Germany on the low-voltage level. Typically, fixed network topologies are examined or a Monte Carlo approach is used to quantify the investment needs at this voltage level. Recent research has revealed that DERs differ substantially between rural, suburban and urban regions. The low-voltage network topologies have different design concepts in these regions, so that different network topologies have to be considered when assessing the need for network extensions and investments due to DERs. An extension algorithm is needed to calculate network extensions and investment needs for the different typologies of generic low-voltage networks. We therefore present a new algorithm, which is capable of calculating the extension for generic low-voltage networks of any given topology based on voltage range deviations and thermal overloads. The algorithm requires information about line and cable lengths, their topology and the network state only. We test the algorithm on a radial, a loop, and a heavily meshed network. Here we show that the algorithm functions for electrical networks with these topologies. We found that the algorithm is able to extend different networks efficiently by placing cables between network nodes. The main value of the algorithm is that it does not require any information about routes for additional cables or positions for additional substations when it comes to estimating network extension needs.

  7. Evaluation of Load Analysis Methods for NASAs GIII Adaptive Compliant Trailing Edge Project

    NASA Technical Reports Server (NTRS)

    Cruz, Josue; Miller, Eric J.

    2016-01-01

    The Air Force Research Laboratory (AFRL), NASA Armstrong Flight Research Center (AFRC), and FlexSys Inc. (Ann Arbor, Michigan) have collaborated to flight test the Adaptive Compliant Trailing Edge (ACTE) flaps. These flaps were installed on a Gulfstream Aerospace Corporation (GAC) GIII aircraft and tested at AFRC at various deflection angles over a range of flight conditions. External aerodynamic and inertial load analyses were conducted with the intention to ensure that the change in wing loads due to the deployed ACTE flap did not overload the existing baseline GIII wing box structure. The objective of this paper was to substantiate the analysis tools used for predicting wing loads at AFRC. Computational fluid dynamics (CFD) models and distributed mass inertial models were developed for predicting the loads on the wing. The analysis tools included TRANAIR (full potential) and CMARC (panel) models. Aerodynamic pressure data from the analysis codes were validated against static pressure port data collected in-flight. Combined results from the CFD predictions and the inertial load analysis were used to predict the normal force, bending moment, and torque loads on the wing. Wing loads obtained from calibrated strain gages installed on the wing were used for substantiation of the load prediction tools. The load predictions exhibited good agreement compared to the flight load results obtained from calibrated strain gage measurements.

  8. KSC-01pp1486

    NASA Image and Video Library

    2001-08-22

    KENNEDY SPACE CENTER, Fla. - With its drag chute trailing behind, orbiter Discovery and its crew land on KSC's Shuttle Landing Facility runway 15. Main gear touchdown was at 2:22:58 p.m. EDT; wheel stop, at 2:24:06 p.m. EDT. The 11-day, 21-hour, 12-minute STS-105 mission accomplished the goals set for the 11th flight to the International Space Station: swapout of the resident Station crew; delivery of equipment, supplies and scientific experiments; and installation of the Early Ammonia Servicer and heater cables for the S0 truss on the Station. Discovery traveled 4.3 million miles on its 30th flight into space, the 106th mission of the Space Shuttle program. Out of five missions in 2001, the landing was the first to occur in daylight at KSC

  9. Full pillar extraction at the Kathleen Mine with mobile roof supports

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Grimm, E.S.

    1994-12-31

    The Voest Alpine Breaker Line Supports (ABLS) resemble self-propelled longwall shields. Each individual unit consists of four hydraulic legs extending from the base of the unit, pressing a solid flat canopy against the mine roof. Each support unit is capable of exerting 606 tons of force against the roof. A chain curtain on the sides and rear protects the interior of the support from falling rock. The internal scissoring lemniscate design allows for parallel movement of the canopy as it is raised or lowered. Each ABLS has 750 feet of 4 AWG trailing cable to supply 480 volts AC tomore » a permissible controller and a 40 hp explosion-proof electrical motor. The hydraulic pump and reservoir are self-contained and protected with an automatic fire suppression system.« less

  10. Assessment of alternative power sources for mobile mining machinery

    NASA Technical Reports Server (NTRS)

    Cairelli, J. E.; Tomazic, W. A.; Evans, D. G.; Klann, J. L.

    1981-01-01

    Alternative mobile power sources for mining applications were assessed. A wide variety of heat engines and energy systems was examined as potential alternatives to presently used power systems. The present mobile power systems are electrical trailing cable, electrical battery, and diesel - with diesel being largely limited in the United States to noncoal mines. Each candidate power source was evaluated for the following requirements: (1) ability to achieve the duty cycle; (2) ability to meet Government regulations; (3) availability (production readiness); (4) market availability; and (5) packaging capability. Screening reduced the list of candidates to the following power sources: diesel, stirling, gas turbine, rankine (steam), advanced electric (batteries), mechanical energy storage (flywheel), and use of hydrogen evolved from metal hydrides. This list of candidates is divided into two classes of alternative power sources for mining applications, heat engines and energy storage systems.

  11. KSC01padig272

    NASA Image and Video Library

    2001-08-22

    KENNEDY SPACE CENTER, Fla. -- Completing mission STS-105, orbiter Discovery and its crew drop through scattered clouds to land on KSC's Shuttle Landing Facility runway 15. Discovery trails its drag chute that helps slow the orbiter. Main gear touchdown was at 2:22:58 p.m. EDT, wheel stop at 2:24:06 p.m. EDT. The 11-day, 21-hour, 12-minute mission accomplished the goals set for the 11th flight to the International Space Station: swapout of the resident Station crew, delivery of equipment supplies and scientific experiments, and installation of the Early Ammonia Servicer and heater cables for the S0 truss on the Station. Discovery traveled 4.3 million miles on its 30th flight into space, the 106th mission of the Space Shuttle program. The landing was the first out of five in 2001to occur in daylight at KSC

  12. Discovery lands at KSC after completing mission STS-105

    NASA Technical Reports Server (NTRS)

    2001-01-01

    KENNEDY SPACE CENTER, Fla. With its drag chute trailing behind, orbiter Discovery and its crew land on KSC's Shuttle Landing Facility runway 15. Main gear touchdown was at 2:22:58 p.m. EDT; wheel stop, at 2:24:06 p.m. EDT. The 11-day, 21-hour, 12-minute STS-105 mission accomplished the goals set for the 11th flight to the International Space Station: swapout of the resident Station crew; delivery of equipment, supplies and scientific experiments; and installation of the Early Ammonia Servicer and heater cables for the S0 truss on the Station. Discovery traveled 4.3 million miles on its 30th flight into space, the 106th mission of the Space Shuttle program. The landing was the first of five in 2001 to occur in daylight at KSC.

  13. Assessment of alternative power sources for mobile mining machinery

    NASA Astrophysics Data System (ADS)

    Cairelli, J. E.; Tomazic, W. A.; Evans, D. G.; Klann, J. L.

    1981-12-01

    Alternative mobile power sources for mining applications were assessed. A wide variety of heat engines and energy systems was examined as potential alternatives to presently used power systems. The present mobile power systems are electrical trailing cable, electrical battery, and diesel - with diesel being largely limited in the United States to noncoal mines. Each candidate power source was evaluated for the following requirements: (1) ability to achieve the duty cycle; (2) ability to meet Government regulations; (3) availability (production readiness); (4) market availability; and (5) packaging capability. Screening reduced the list of candidates to the following power sources: diesel, stirling, gas turbine, rankine (steam), advanced electric (batteries), mechanical energy storage (flywheel), and use of hydrogen evolved from metal hydrides. This list of candidates is divided into two classes of alternative power sources for mining applications, heat engines and energy storage systems.

  14. Discovery lands at KSC after completing mission STS-105

    NASA Technical Reports Server (NTRS)

    2001-01-01

    KENNEDY SPACE CENTER, Fla. With its drag chute trailing behind, orbiter Discovery and its crew land on KSC's Shuttle Landing Facility runway 15. The 525-foot-tall Vehicle Assembly Building can be seen in the background. Main gear touchdown was at 2:22:58 p.m. EDT; wheel stop, at 2:24:06 p.m. EDT. The 11-day, 21-hour, 12-minute STS-105 mission accomplished the goals set for the 11th flight to the International Space Station: swapout of the resident Station crew; delivery of equipment, supplies and scientific experiments; and installation of the Early Ammonia Servicer and heater cables for the S0 truss on the Station. Discovery traveled 4.3 million miles on its 30th flight into space, the 106th mission of the Space Shuttle program. The landing was the first of five in 2001 to occur in daylight at KSC.

  15. Lockheed Martin T-Rex: Preliminary report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1997-07-31

    T-Rex is a robot which may be used in toxic or flammable environments. The assessment of the T-Rex conducted at the Lockheed Martin facility was limited in its scope. The scope of the assessment was directed by the type of equipment being used and the amount of accessibility to the equipment. Due to severe time constraints--the assessment was conducted in one day--human factors interface activities were limited. This should be considered a preliminary assessment. This report covers aspects of the technology that were available to the assessment team. Recommendations for future evaluation of this technology are also included. The contentsmore » are as follows: Electrical Considerations; General Electrical Consideration; Trailing Cables; Grounding; Surface High Voltage Distribution; Low and Medium Voltage Alternating Current Circuits; Potential for Harmful Human Factor Incidents and Enterprise Disablement; Exclusion Zone Emergency Maintenance; and Recommendations.« less

  16. In-Containment Signal Acquisition and Data Transmission via Power Lines within High Dose Areas of Nuclear Power Plants

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mueller Steffen; Wibbing Sascha; Weigel Robert

    2015-07-01

    Signal acquisition and data transmission for innovative sensor systems and networks inside the containment of nuclear power plants (NPPs) is still a challenge with respect to safety, performance, reliability, availability, and costs. This especially applies to equipment upgrades for existing plants, special measurements, but also for new builds. This paper presents a novel method for efficient and cost-effective sensor signal acquisition and data transmission via power lines, in order to cope with the disadvantages of common system architectures that often suffer from poor signal integrity due to raw data transmissions via long cables, huge efforts and costs for installation, andmore » low flexibility with respect to maintenance and upgrades. A transmitter-receiver architecture is proposed that allows multiplexing of multiple sensor inputs for unidirectional point-to-point transmission by superimposing information signals on existing AC or DC supply lines, but also on active and inactive sensor wires, or spare cables, using power line communication (PLC) technology. Based on commercial off-the-shelf (COTS) electronic parts, a radiation hard transmitter hardware is designed to operate in harsh environment within the containment during full plant operation. The system's modular approach allows application specific trade-offs between redundancy and throughput regarding data transmission, as well as various sensor input front-ends which are compatible with state of the art systems. PLC technology eliminates the need for costly installation of additional cables and wall penetrations, while providing a complementary and diverse communication technology for upgrades of existing systems. At the receiver side in low dose areas, signals are extracted from the power line, demodulated, and de-multiplexed, in order to regain the original sensor signal information and provide it either in analog or digital output format. Successful laboratory qualification tests, field trails, and a demonstrator setup installation within a NPP verify the overall performance of the proposed system. (authors)« less

  17. Overloaded and stressed: A case study of women working in the health care sector.

    PubMed

    Stevenson, Maggie; Duxbury, Linda

    2018-04-23

    Although role overload has been shown to be prevalent and consequential, there has been little attempt to develop the associated theory. The fact that the consequences of role overload can be positive or negative implies that the relationship between role overload and perceived stress depends partly on the environment within which role overload is experienced (i.e., the perceived situation) and how the situation is evaluated (i.e., appraised). Guided by cognitive appraisal theory, this study applies qualitative methodology to identify the situation properties that contribute to variable stress reactions to role overload. In this in-depth examination, overloaded female hospital workers were asked to describe what makes role overload situations potentially stressful, to gain an insight into how role overload is appraised. A taxonomy listing 12 role overload situation properties was developed from the findings, providing the first known classification of the situation properties of role overload that can create the potential for stress. The results also reveal clues as to why some people suffer more stress during role overload than others, increase our understanding of the relationship between role overload and perceived stress, and provide a useful tool for examining the environment of role overload. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  18. Comparison of deferiprone and deferrioxamine for the treatment of transfusional iron overload in children with beta thalassemia major.

    PubMed

    Waheed, Nadia; Ali, Shafqut; Butt, Muhammad Asghar

    2014-01-01

    Thalassemia major is the most common genetic disorder in Pakistan. The study was done to compare the efficacy and safety of the deferiprone with deferrioxamine for the treatment of iron overload in children with thalassemia major. This randomized controlled trail was conducted at thalassemia blood transfusion unit of Allied Hospital, Faisalabad (AHF)/District Headquarter Hospital (DHQ), Faisalabad. Thalassemia-Unit Hilal-e-Ahmar, Alizeb Foundation and Blood Bank Services Faisalabad from November 2010 to December 2011.Children with beta thalassemia major of age more than 2 years and less than 16 years with transfusion iron over load were randomly allocated to one of the two groups each comprising of 67 patients. One group received deferiprone given at a daily dose of 75mg/kg in three divided doses orally while the other group received deferrioxamine at dose 50 mg/kg/24hrs for 5 days/week as parental infusion. Changes in the serum ferritin level were assessed. Cardiac function and toxicity were also examined. Serum ferritin was significantly reduced after 1 year in both treatment arms (p=0.01). Neutropenia observed in 13 (19.40%) non-splenectomized patients taking deferiprone. Transient elevations in ALT were observed in 3 (4.47%) children taking deferiprone. Left ventricular ejection fraction (LVEF) remained in normal range in both treatment arm but has decreased significantly in Deferrioxamine group compliance. Compliance was better in deferiprone as compared to deferrioxamine. Discontinuing percentage 2 (3%) vs 9 (13.43%). Deferiprone is a highly efficacious and safe chelation therapy for patients with thalassemia major who are non-compliant to Deferrioxamine. Deferiprone have an efficacy profile comparable to standard Deferrioxamine.

  19. The role of fluid overload in the prediction of outcome in acute kidney injury.

    PubMed

    Selewski, David T; Goldstein, Stuart L

    2018-01-01

    Our understanding of the epidemiology and the impact of acute kidney injury (AKI) and fluid overload on outcomes has improved significantly over the past several decades. Fluid overload occurs commonly in critically ill children with and without associated AKI. Researchers in pediatric AKI have been at the forefront of describing the impact of fluid overload on outcomes in a variety of populations. A full understanding of this topic is important as fluid overload represents a potentially modifiable risk factor and a target for intervention. In this state-of-the-art review, we comprehensively describe the definition of fluid overload, the impact of fluid overload on kidney function, the impact of fluid overload on the diagnosis of AKI, the association of fluid overload with outcomes, the targeted therapy of fluid overload, and the impact of the timing of renal replacement therapy on outcomes.

  20. Iron-overload injury and cardiomyopathy in acquired and genetic models is attenuated by resveratrol therapy.

    PubMed

    Das, Subhash K; Wang, Wang; Zhabyeyev, Pavel; Basu, Ratnadeep; McLean, Brent; Fan, Dong; Parajuli, Nirmal; DesAulniers, Jessica; Patel, Vaibhav B; Hajjar, Roger J; Dyck, Jason R B; Kassiri, Zamaneh; Oudit, Gavin Y

    2015-12-07

    Iron-overload cardiomyopathy is a prevalent cause of heart failure on a world-wide basis and is a major cause of mortality and morbidity in patients with secondary iron-overload and genetic hemochromatosis. We investigated the therapeutic effects of resveratrol in acquired and genetic models of iron-overload cardiomyopathy. Murine iron-overload models showed cardiac iron-overload, increased oxidative stress, altered Ca(2+) homeostasis and myocardial fibrosis resulting in heart disease. Iron-overload increased nuclear and acetylated levels of FOXO1 with corresponding inverse changes in SIRT1 levels in the heart corrected by resveratrol therapy. Resveratrol, reduced the pathological remodeling and improved cardiac function in murine models of acquired and genetic iron-overload at varying stages of iron-overload. Echocardiography and hemodynamic analysis revealed a complete normalization of iron-overload mediated diastolic and systolic dysfunction in response to resveratrol therapy. Myocardial SERCA2a levels were reduced in iron-overloaded hearts and resveratrol therapy restored SERCA2a levels and corrected altered Ca(2+) homeostasis. Iron-mediated pro-oxidant and pro-fibrotic effects in human and murine cardiomyocytes and cardiofibroblasts were suppressed by resveratrol which correlated with reduction in iron-induced myocardial oxidative stress and myocardial fibrosis. Resveratrol represents a clinically and economically feasible therapeutic intervention to reduce the global burden from iron-overload cardiomyopathy at early and chronic stages of iron-overload.

  1. Iron-overload injury and cardiomyopathy in acquired and genetic models is attenuated by resveratrol therapy

    PubMed Central

    Das, Subhash K.; Wang, Wang; Zhabyeyev, Pavel; Basu, Ratnadeep; McLean, Brent; Fan, Dong; Parajuli, Nirmal; DesAulniers, Jessica; Patel, Vaibhav B.; Hajjar, Roger J.; Dyck, Jason R. B.; Kassiri, Zamaneh; Oudit, Gavin Y.

    2015-01-01

    Iron-overload cardiomyopathy is a prevalent cause of heart failure on a world-wide basis and is a major cause of mortality and morbidity in patients with secondary iron-overload and genetic hemochromatosis. We investigated the therapeutic effects of resveratrol in acquired and genetic models of iron-overload cardiomyopathy. Murine iron-overload models showed cardiac iron-overload, increased oxidative stress, altered Ca2+ homeostasis and myocardial fibrosis resulting in heart disease. Iron-overload increased nuclear and acetylated levels of FOXO1 with corresponding inverse changes in SIRT1 levels in the heart corrected by resveratrol therapy. Resveratrol, reduced the pathological remodeling and improved cardiac function in murine models of acquired and genetic iron-overload at varying stages of iron-overload. Echocardiography and hemodynamic analysis revealed a complete normalization of iron-overload mediated diastolic and systolic dysfunction in response to resveratrol therapy. Myocardial SERCA2a levels were reduced in iron-overloaded hearts and resveratrol therapy restored SERCA2a levels and corrected altered Ca2+ homeostasis. Iron-mediated pro-oxidant and pro-fibrotic effects in human and murine cardiomyocytes and cardiofibroblasts were suppressed by resveratrol which correlated with reduction in iron-induced myocardial oxidative stress and myocardial fibrosis. Resveratrol represents a clinically and economically feasible therapeutic intervention to reduce the global burden from iron-overload cardiomyopathy at early and chronic stages of iron-overload. PMID:26638758

  2. Overload effect and fatigue crack propagation in amorphous metallic alloys

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chaki, T.K.; Li, J.C.M.

    1984-07-01

    Fatigue crack propagation in amorphous metals has an overload effect which usually increases with the number of overload cycles. The variation of overload effect with delta K is explained by the size of the plastic zone which depends on delta K. A comparison of the spacing between striations and da/dN shows that the crack jumps a step about every hundred cycles. The featureless region is probably due to shear fracture along a shear band during overload. Both crack tip blunting and branching occur during the application of overload. Work hardening is not a necessary factor for the overloading effect.

  3. Overloading among crash-involved vehicles in China: identification of factors associated with overloading and crash severity.

    PubMed

    Zhang, Guangnan; Li, Yanyan; King, Mark J; Zhong, Qiaoting

    2018-03-21

    Motor vehicle overloading is correlated with the possibility of road crash occurrence and severity. Although overloading of motor vehicles is pervasive in developing nations, few empirical analyses have been performed on factors that might influence the occurrence of overloading. This study aims to address this shortcoming by seeking evidence from several years of crash data from Guangdong province, China. Data on overloading and other factors are extracted for crash-involved vehicles from traffic crash records for 2006-2010 provided by the Traffic Management Bureau in Guangdong province. Logistic regression is applied to identify risk factors for overloading in crash-involved vehicles and within these crashes to identify factors contributing to greater crash severity. Driver, vehicle, road and environmental characteristics and violation types are considered in the regression models. In addition to the basic logistic models, association analysis is employed to identify the potential interactions among different risk factors during fitting the logistic models of overloading and severity. Crash-involved vehicles driven by males from rural households and in an unsafe condition are more likely to be overloaded and to be involved in higher severity overloaded vehicle crashes. If overloaded vehicles speed, the risk of severe traffic crash casualties increases. Young drivers (aged under 25 years) in mountainous areas are more likely to be involved in higher severity overloaded vehicle crashes. This study identifies several factors associated with overloading in crash-involved vehicles and with higher severity overloading crashes and provides an important reference for future research on those specific risk factors. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  4. Females Are Protected From Iron-Overload Cardiomyopathy Independent of Iron Metabolism: Key Role of Oxidative Stress.

    PubMed

    Das, Subhash K; Patel, Vaibhav B; Basu, Ratnadeep; Wang, Wang; DesAulniers, Jessica; Kassiri, Zamaneh; Oudit, Gavin Y

    2017-01-23

    Sex-related differences in cardiac function and iron metabolism exist in humans and experimental animals. Male patients and preclinical animal models are more susceptible to cardiomyopathies and heart failure. However, whether similar differences are seen in iron-overload cardiomyopathy is poorly understood. Male and female wild-type and hemojuvelin-null mice were injected and fed with a high-iron diet, respectively, to develop secondary iron overload and genetic hemochromatosis. Female mice were completely protected from iron-overload cardiomyopathy, whereas iron overload resulted in marked diastolic dysfunction in male iron-overloaded mice based on echocardiographic and invasive pressure-volume analyses. Female mice demonstrated a marked suppression of iron-mediated oxidative stress and a lack of myocardial fibrosis despite an equivalent degree of myocardial iron deposition. Ovariectomized female mice with iron overload exhibited essential pathophysiological features of iron-overload cardiomyopathy showing distinct diastolic and systolic dysfunction, severe myocardial fibrosis, increased myocardial oxidative stress, and increased expression of cardiac disease markers. Ovariectomy prevented iron-induced upregulation of ferritin, decreased myocardial SERCA2a levels, and increased NCX1 levels. 17β-Estradiol therapy rescued the iron-overload cardiomyopathy in male wild-type mice. The responses in wild-type and hemojuvelin-null female mice were remarkably similar, highlighting a conserved mechanism of sex-dependent protection from iron-overload-mediated cardiac injury. Male and female mice respond differently to iron-overload-mediated effects on heart structure and function, and females are markedly protected from iron-overload cardiomyopathy. Ovariectomy in female mice exacerbated iron-induced myocardial injury and precipitated severe cardiac dysfunction during iron-overload conditions, whereas 17β-estradiol therapy was protective in male iron-overloaded mice. © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

  5. Physical activity behavior and role overload in mothers.

    PubMed

    Lovell, Geoff P; Butler, Frances R

    2015-01-01

    We examined physical activity stages of change, physical activity behavior, and role overload in different stages of motherhood in a predominantly Australian sample. Neither physical activity behavior, stages of physical activity change, nor role overload significantly differed across motherhood groups. Role overload was significantly higher for mothers in the contemplation, planning, and action stages of physical activity than in the maintenance stage of change. Role overload had a weak, although significant, negative correlation with leisure-time physical activity. We conclude that strategies focused upon reducing role overload or perceived role overload have only limited potential to meaningfully increase leisure-time physical activity in mothers.

  6. Iron overload patients with unknown etiology from national survey in Japan.

    PubMed

    Ikuta, Katsuya; Hatayama, Mayumi; Addo, Lynda; Toki, Yasumichi; Sasaki, Katsunori; Tatsumi, Yasuaki; Hattori, Ai; Kato, Ayako; Kato, Koichi; Hayashi, Hisao; Suzuki, Takahiro; Kobune, Masayoshi; Tsutsui, Miyuki; Gotoh, Akihiko; Aota, Yasuo; Matsuura, Motoo; Hamada, Yuzuru; Tokuda, Takahiro; Komatsu, Norio; Kohgo, Yutaka

    2017-03-01

    Transfusion is believed to be the main cause of iron overload in Japan. A nationwide survey on post-transfusional iron overload subsequently led to the establishment of guidelines for iron chelation therapy in this country. To date, however, detailed clinical information on the entire iron overload population in Japan has not been fully investigated. In the present study, we obtained and studied detailed clinical information on the iron overload patient population in Japan. Of 1109 iron overload cases, 93.1% were considered to have occurred post-transfusion. There were, however, 76 cases of iron overload of unknown origin, which suggest that many clinicians in Japan may encounter some difficulty in correctly diagnosing and treating iron overload. Further clinical data were obtained for 32 cases of iron overload of unknown origin; median of serum ferritin was 1860.5 ng/mL. As occurs in post-transfusional iron overload, liver dysfunction was found to be as high as 95.7% when serum ferritin levels exceeded 1000 ng/mL in these patients. Gene mutation analysis of the iron metabolism-related genes in 27 cases of iron overload with unknown etiology revealed mutations in the gene coding hemojuvelin, transferrin receptor 2, and ferroportin; this indicates that although rare, hereditary hemochromatosis does occur in Japan.

  7. Fluid imbalance

    MedlinePlus

    ... up in the body. This is called fluid overload (volume overload). This can lead to edema (excess fluid in ... Water imbalance; Fluid imbalance - dehydration; Fluid buildup; Fluid overload; Volume overload; Loss of fluids; Edema - fluid imbalance; ...

  8. A comparison of selected models for estimating cable icing

    NASA Astrophysics Data System (ADS)

    McComber, Pierre; Druez, Jacques; Laflamme, Jean

    In many cold climate countries, it is becoming increasingly important to monitor transmission line icing. Indeed, by knowing in advance of localized danger for icing overloads, electric utilities can take measures in time to prevent generalized failure of the power transmission network. Recently in Canada, a study was made to compare the estimation of a few icing models working from meteorological data in estimating ice loads for freezing rain events. The models tested were using only standard meteorological parameters, i.e. wind speed and direction, temperature and precipitation rate. This study has shown that standard meteorological parameters can only achieve very limited accuracy, especially for longer icing events. However, with the help of an additional instrument monitoring the icing rate intensity, a significant improvement in model prediction might be achieved. The icing rate meter (IRM) which counts icing and de-icing cycles per unit time on a standard probe can be used to estimate the icing intensity. A cable icing estimation is then made by taking into consideration the accretion size, temperature, wind speed and direction, and precipitation rate. In this paper, a comparison is made between the predictions of two previously tested models (one obtained and the other reconstructed from their description in the public literature) and of a model based on the icing rate meter readings. The models are tested against nineteen events recorded on an icing test line at Mt. Valin, Canada, during the winter season 1991-1992. These events are mostly rime resulting from in-cloud icing. However, freezing rain and wet snow events were also recorded. Results indicate that a significant improvement in the estimation is attained by using the icing rate meter data together with the other standard meteorological parameters.

  9. A Novel Approach to Apply Gait Synchronized External Forces on the Pelvis using A-TPAD to Reduce Walking Effort

    PubMed Central

    Vashista, Vineet; Khan, Moiz; Agrawal, Sunil K.

    2017-01-01

    In this paper, we develop an intervention to apply external gait synchronized forces on the pelvis to reduce the user’s effort during walking. A cable-driven robot was used to apply the external forces and an adaptive frequency oscillator scheme was developed to adapt the timing of force actuation to the gait frequency during walking. The external forces were directed in the sagittal plane to assist the trailing leg during the forward propulsion and vertical deceleration of the pelvis during the gait cycle. A pilot experiment with five healthy subjects was conducted. The results showed that the subjects applied lower ground reaction forces in the vertical and anterior-posterior directions during the late stance phase. In summary, the current work provides a novel approach to study the role of external pelvic forces in altering the walking effort. These studies can provide better understanding for designing exoskeletons and prosthetic devices to reduce the overall walking effort. PMID:29623294

  10. Current limiting remote power control module

    NASA Technical Reports Server (NTRS)

    Hopkins, Douglas C.

    1990-01-01

    The power source for the Space Station Freedom will be fully utilized nearly all of the time. As such, any loads on the system will need to operate within expected limits. Should any load draw an inordinate amount of power, the bus voltage for the system may sag and disrupt the operation of other loads. To protect the bus and loads some type of power interface between the bus and each load must be provided. This interface is most crucial when load faults occur. A possible system configuration is presented. The proposed interface is the Current Limiting Remote Power Controller (CL-RPC). Such an interface should provide the following power functions: limit overloading and resulting undervoltage; prevent catastrophic failure and still provide for redundancy management within the load; minimize cable heating; and provide accurate current measurement. A functional block diagram of the power processing stage of a CL-RPC is included. There are four functions that drive the circuit design: rate control of current; current sensing; the variable conductance switch (VCS) technology; and the algorithm used for current limiting. Each function is discussed separately.

  11. Interdisciplinary Research and Information Overload.

    ERIC Educational Resources Information Center

    Wilson, Patrick

    1996-01-01

    Discusses information overload and examines several ways in which actual and potential overload affects research choices for the solo researcher in interdisciplinary areas. Topics include information overload and teamwork; entry barriers to certain specialties, including necessary background knowledge; and information utilization and knowledge…

  12. An Evaluation of Overload Retardation Behavior and Overload Retardation Models of Ti-6Al-4V Sheet Titanium Alloy,

    DTIC Science & Technology

    1983-11-17

    Oat"UaL msue.(rm ~10"ee 66147 effe% nowe. 1.12a, **04 VON"* a Poest 46"a of04 ~ ah es ie [Z-3)~ totego~is f ht * g IM M..s~U~ -• - - -- L.. s. K varying...time course.* That £ 5 , the method of combining and considering the overload retardation models on the basis of the successive accumlation method in...Hysteresis stage of overload retardation (B); 3) Maximum retardation point of overload (C); 4) weakened stage of overload retardation’CD); 5 ) Basic

  13. Iron overload promotes erythroid apoptosis through regulating HIF-1a/ROS signaling pathway in patients with myelodysplastic syndrome.

    PubMed

    Zheng, Qing-Qing; Zhao, You-Shan; Guo, Juan; Zhao, Si-da; Song, Lu-Xi; Fei, Cheng-Ming; Zhang, Zheng; Li, Xiao; Chang, Chun-Kang

    2017-07-01

    Erythroid apoptosis increases significantly in myelodysplastic syndrome (MDS) patients with iron overload, but the underlying mechanism is not fully clear. In this study, we aim to explore the effect of HIF-1a/ROS on erythroid apoptosis in MDS patients with iron overload. We found that iron overload injured cellular functions through up-regulating ROS levels in MDS/AML cells, including inhibited cell viability, increased cell apoptosis and blocked cell cycle at G0/G1 phase. Interestingly, overexpression of hypoxia inducible factor-1a (HIF-1a), which was under-expressed in iron overload models, reduced ROS levels and attenuated cell damage caused by iron overload in MDS/AML cells. And gene knockdown of HIF-1a got the similar results as iron overload in MDS/AML cells. Furthermore, iron overload caused high erythroid apoptosis was closely related with ROS in MDS patients. Importantly, the HIF-1a protein levels of erythrocytes elevated obviously after incubation with desferrioxamine (DFO) from MDS patients with iron overload, accompanied by ROS levels inhibited and erythroid apoptosis reduced. Taken together, our findings determine that the HIF-1a/ROS signaling pathway plays a key role in promoting erythroid apoptosis in MDS patients with iron overload. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. GLUT4 Is Not Necessary for Overload-Induced Glucose Uptake or Hypertrophic Growth in Mouse Skeletal Muscle

    PubMed Central

    McMillin, Shawna L.; Schmidt, Denise L.; Kahn, Barbara B.

    2017-01-01

    GLUT4 is necessary for acute insulin- and contraction-induced skeletal muscle glucose uptake, but its role in chronic muscle loading (overload)-induced glucose uptake is unknown. Our goal was to determine whether GLUT4 is required for overload-induced glucose uptake. Overload was induced in mouse plantaris muscle by unilateral synergist ablation. After 5 days, muscle weights and ex vivo [3H]-2-deoxy-d-glucose uptake were assessed. Overload-induced muscle glucose uptake and hypertrophic growth were not impaired in muscle-specific GLUT4 knockout mice, demonstrating that GLUT4 is not necessary for these processes. To assess which transporters mediate overload-induced glucose uptake, chemical inhibitors were used. The facilitative GLUT inhibitor cytochalasin B, but not the sodium-dependent glucose cotransport inhibitor phloridzin, prevented overload-induced uptake demonstrating that GLUTs mediate this effect. To assess which GLUT, hexose competition experiments were performed. Overload-induced [3H]-2-deoxy-d-glucose uptake was not inhibited by d-fructose, demonstrating that the fructose-transporting GLUT2, GLUT5, GLUT8, and GLUT12 do not mediate this effect. To assess additional GLUTs, immunoblots were performed. Overload increased GLUT1, GLUT3, GLUT6, and GLUT10 protein levels twofold to fivefold. Collectively, these results demonstrate that GLUT4 is not necessary for overload-induced muscle glucose uptake or hypertrophic growth and suggest that GLUT1, GLUT3, GLUT6, and/or GLUT10 mediate overload-induced glucose uptake. PMID:28279980

  15. GLUT4 Is Not Necessary for Overload-Induced Glucose Uptake or Hypertrophic Growth in Mouse Skeletal Muscle.

    PubMed

    McMillin, Shawna L; Schmidt, Denise L; Kahn, Barbara B; Witczak, Carol A

    2017-06-01

    GLUT4 is necessary for acute insulin- and contraction-induced skeletal muscle glucose uptake, but its role in chronic muscle loading (overload)-induced glucose uptake is unknown. Our goal was to determine whether GLUT4 is required for overload-induced glucose uptake. Overload was induced in mouse plantaris muscle by unilateral synergist ablation. After 5 days, muscle weights and ex vivo [ 3 H]-2-deoxy-d-glucose uptake were assessed. Overload-induced muscle glucose uptake and hypertrophic growth were not impaired in muscle-specific GLUT4 knockout mice, demonstrating that GLUT4 is not necessary for these processes. To assess which transporters mediate overload-induced glucose uptake, chemical inhibitors were used. The facilitative GLUT inhibitor cytochalasin B, but not the sodium-dependent glucose cotransport inhibitor phloridzin, prevented overload-induced uptake demonstrating that GLUTs mediate this effect. To assess which GLUT, hexose competition experiments were performed. Overload-induced [ 3 H]-2-deoxy-d-glucose uptake was not inhibited by d-fructose, demonstrating that the fructose-transporting GLUT2, GLUT5, GLUT8, and GLUT12 do not mediate this effect. To assess additional GLUTs, immunoblots were performed. Overload increased GLUT1, GLUT3, GLUT6, and GLUT10 protein levels twofold to fivefold. Collectively, these results demonstrate that GLUT4 is not necessary for overload-induced muscle glucose uptake or hypertrophic growth and suggest that GLUT1, GLUT3, GLUT6, and/or GLUT10 mediate overload-induced glucose uptake. © 2017 by the American Diabetes Association.

  16. Dietary glutamine supplementation partly reverses impaired macrophage function resulting from overload training in rats.

    PubMed

    Xiao, Weihua; Chen, Peijie; Dong, Jingmei; Wang, Ru; Luo, Beibei

    2015-04-01

    The aim of this study was to evaluate the effect of overload training on the function of peritoneal macrophages in rats, and to test the hypothesis that glutamine in vivo supplementation would partly reverse the eventual functional alterations induced by overload training in these cells. Forty male Wistar rats were randomly divided into 5 groups: control group (C), overload training group (E1), overload training and restore one week group (E2), glutamine-supplementation group (EG1), and glutamine-supplementation and restore 1-week group (EG2). All rats, except those placed on sedentary control were subjected to 11 weeks of overload training protocol. Blood hemoglobin, serum testosterone, and corticosterone of rats were measured. Moreover, the functions (chemotaxis, phagocytosis, cytokines synthesis, reactive oxygen species generation) of peritoneal macrophages were determined. Data showed that blood hemoglobin, serum testosterone, corticosterone and body weight in the overload training group decreased significantly as compared with the control group. Meanwhile, the chemotaxis capacity (decreased by 31%, p = .003), the phagocytosis capacity (decreased by 27%, p = .005), the reactive oxygen species (ROS) generation (decreased by 35%, p = .003) and the cytokines response capability of macrophages were inhibited by overload training. However, the hindering of phagocytosis and the cytokines response capability of macrophages induced by overload training could be ameliorated and reversed respectively, by dietary glutamine supplementation. These results suggest that overload training impairs the function of peritoneal macrophages, which is essential for the microbicidal actions of macrophages. This may represent a novel mechanism of immunodepression induced by overload training. Nonetheless, dietary glutamine supplementation could partly reverse the impaired macrophage function resulting from overload training.

  17. TIMP3 deficiency exacerbates iron overload-mediated cardiomyopathy and liver disease.

    PubMed

    Zhabyeyev, Pavel; Das, Subhash K; Basu, Ratnadeep; Shen, Mengcheng; Patel, Vaibhav B; Kassiri, Zamaneh; Oudit, Gavin Y

    2018-05-01

    Chronic iron overload results in heart and liver diseases and is a common cause of morbidity and mortality in patients with genetic hemochromatosis and secondary iron overload. We investigated the role of tissue inhibitor of metalloproteinase 3 (TIMP3) in iron overload-mediated tissue injury by subjecting male mice lacking Timp3 ( Timp3 -/- ) and wild-type (WT) mice to 12 wk of chronic iron overload. Whereas WT mice with iron overload developed diastolic dysfunction, iron-overloaded Timp3 -/- mice showed worsened cardiac dysfunction coupled with systolic dysfunction. In the heart, loss of Timp3 was associated with increased myocardial fibrosis, greater Timp1, matrix metalloproteinase ( Mmp) 2, and Mmp9 expression, increased active MMP-2 levels, and gelatinase activity. Iron overload in Timp3 -/- mice showed twofold higher iron accumulation in the liver compared with WT mice because of constituently lower levels of ferroportin. Loss of Timp3 enhanced the hepatic inflammatory response to iron overload, leading to greater neutrophil and macrophage infiltration and increased hepatic fibrosis. Expression of inflammation-related MMPs (MMP-12 and MMP-13) and inflammatory cytokines (IL-1β and monocyte chemoattractant protein-1) was elevated to a greater extent in iron-overloaded Timp3 -/- livers. Gelatin zymography demonstrated equivalent increases in MMP-2 and MMP-9 levels in WT and Timp3 -/- iron-overloaded livers. Loss of Timp3 enhanced the susceptibility to iron overload-mediated heart and liver injury, suggesting that Timp3 is a key protective molecule against iron-mediated pathology. NEW & NOTEWORTHY In mice, loss of tissue inhibitor of metalloproteinase 3 ( Timp3) was associated with systolic and diastolic dysfunctions, twofold higher hepatic iron accumulation (attributable to constituently lower levels of ferroportin), and increased hepatic inflammation. Loss of Timp3 enhanced the susceptibility to iron overload-mediated injury, suggesting that Timp3 plays a key protective role against iron-mediated pathology.

  18. Work Overload.

    ERIC Educational Resources Information Center

    Bateman, Thomas S.

    1980-01-01

    To investigate managerial use of work (or role) overload to increase productivity, the author studied 77 nonclerical white-collar employees and found that work overload had negative effects on productivity, supervisors' ratings, employee attitudes, job satisfaction, and health. He recommends ways for managers and employees to reduce work overload.…

  19. High-order TRAIL oligomer formation in TRAIL-coated lipid nanoparticles enhances DR5 cross-linking and increases antitumour effect against colon cancer.

    PubMed

    De Miguel, Diego; Gallego-Lleyda, Ana; Ayuso, José María; Pejenaute-Ochoa, Dolores; Jarauta, Vidal; Marzo, Isabel; Fernández, Luis J; Ochoa, Ignacio; Conde, Blanca; Anel, Alberto; Martinez-Lostao, Luis

    2016-12-28

    During the last years, a great effort has been invested into developing new TRAIL formulations with increased bioactivity, trying to overcome the resistance to conventional soluble TRAIL (sTRAIL) exhibited by many primary tumours. In our group, we have generated artificial lipid nanoparticles decorated with sTRAIL (LUV-TRAIL), emulating the physiological TRAIL-containing exosomes by which T-cells release TRAIL upon activation. We already demonstrated that LUV-TRAIL has greater cytotoxicity against both chemoresistant haematologic tumour cells and epithelial carcinoma cells compared to a form of sTRAIL similar to that used in clinical trials. In this study we have tested LUV-TRAIL in several human colon cancer cell lines with different sensitivity to sTRAIL. LUV-TRAIL significantly improved sTRAIL cytotoxicity in all colon cancer cell lines tested. Trying to ascertain the molecular mechanism by which LUV-TRAIL exhibited improved cytotoxicity, we demonstrated that TRAIL-coated lipid nanoparticles were able to activate DR5 more efficiently than sTRAIL, and this relied on LUV-TRAIL ability to promote DR5 clustering on the cell surface. Moreover, we show that TRAIL molecules are arranged in higher order oligomers only in LUV-TRAIL, which may explain their enhanced DR5 clustering ability. Finally, LUV-TRAIL showed significantly better antitumour activity than sTRAIL in an in vivo model using HCT-116 xenograft tumours in nude mice, validating its potential clinical application. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  20. Thermal Aging Characteristics of Insulation Paper in Mineral Oil under Overloaded Operating Transformers

    NASA Astrophysics Data System (ADS)

    Miyagi, Katsunori; Oe, Etsuo; Yamagata, Naoki; Miyahara, Hideyuki

    A sudden capacity increase in demand during the summer peak, or in contingencies such as malfunctioning transformers, may cause overload for normal transformers. In this paper, on the basis of examples of overloaded transformer operation in distributing substations, thermal aging testing in oil was carried out under various overload patterns, such as short time overload and long time overload, but with the winding insulation paper's life loss kept constant. From the results, various characteristics such as mean degree of polymerization and productions of furfural and (CO2+CO), and their effects on the life loss of the insulation paper were obtained.

  1. Effect of overload on the fatigue crack propagation in metastable beta Ti-V alloys

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chakrabortty, S.B.; Starke, E.A. Jr.; Lee, E.W.

    1984-03-01

    The effects of overload on the fatigue crack propagation behavior of two Ti-V alloys having different deformation mechanisms were studied. The results are explained in terms of residual stress effects associated with the overload and the removal of these stresses during post-overload cycling. An additional effect occurs during multiple cycle overload when the deformation structure representative of the strain amplitude is believed to form in the overload reverse plastic zone. This structure must be rearranged during cycling at Delta Kb before the baseline FCGR is reached and the process is responsible for part of the delay period. 46 references.

  2. Mechanism of trail following by the arboreal termite Nasutitermes corniger (Isoptera: Termitidae).

    PubMed

    Gazai, Vinícius; Bailez, Omar; Viana-Bailez, Ana Maria

    2014-01-01

    In this study, we investigated the mechanisms used by the arboreal termite Nasutitermes corniger (Motschulsky, 1855) to follow trails from the nest to sources of food. A plate containing one of seven trail types was used to connect an artificial nest of N. corniger with an artificial foraging arena. The trail types were: termite trail; paraffined termite trail; trail made of paraffin; rectal fluid extract trail; sternal gland extract trail; feces extract trail; and solvent trail (control). In each test, the time was recorded from the start of the test until the occurrence of trail following, at which point the number of termites that followed the trail for least 5 cm in the first 3 min of observation was recorded. The delay for termites initiating trail following along the termite trail was lower (0.55 ± 0.16 min) than in the trails of sternal gland extract (1.05 ± 0.08 min) and trails of termite feces extract (1.57 ± 0.21 min) (F(2), (48) = 22.59, P < 0.001). The number of termites that followed the termite trail was greater (207.3 ± 17.3) than the number that followed the trail of termite feces extract (102.5 ± 9.4) or sternal gland extract (36, 9 ± 1.6) (F(2), (48) = 174.34, P < 0.001). Therefore, feces on the trail may play an important role alongside sternal gland pheromones in increasing the persistence of the trail.

  3. Contemporary Risk Factors and Outcomes of Transfusion-Associated Circulatory Overload.

    PubMed

    Roubinian, Nareg H; Hendrickson, Jeanne E; Triulzi, Darrell J; Gottschall, Jerome L; Michalkiewicz, Michael; Chowdhury, Dhuly; Kor, Daryl J; Looney, Mark R; Matthay, Michael A; Kleinman, Steven H; Brambilla, Donald; Murphy, Edward L

    2018-04-01

    Transfusion-associated circulatory overload is characterized by hydrostatic pulmonary edema following blood transfusion. Restrictive transfusion practice may affect the occurrence and severity of transfusion-associated circulatory overload in critically ill patients. We sought to examine contemporary risk factors and outcomes for transfusion-associated circulatory overload. Case-control study. Four tertiary care hospitals. We prospectively enrolled 200 patients with transfusion-associated circulatory overload identified by active surveillance and 405 controls matched by transfusion intensity. None. Among 20,845 transfused patients who received 128,263 blood components from May 2015 until July 2016, transfusion-associated circulatory overload incidence was one case per 100 transfused patients. In addition to cardiovascular comorbidities, multivariable analysis identified the following independent predictors of transfusion-associated circulatory overload: acute kidney injury, emergency surgery, pretransfusion diuretic use, and plasma transfusion-the latter especially in females. Compared with matched controls, transfusion-associated circulatory overload cases were more likely to require mechanical ventilation (71% vs 49%; p < 0.001), experienced longer intensive care and hospital lengths of stay following transfusion, and had higher mortality (21% vs 11%; p = 0.02) even after adjustment for other potentially confounding variables. Despite restrictive transfusion practice, transfusion-associated circulatory overload remains a frequent complication of transfusion and is an independent risk factor for in-hospital morbidity and mortality. In addition to cardiovascular and renal risk factors, plasma transfusion was associated with transfusion-associated circulatory overload after controlling for other covariates. Additional research is needed to examine the benefit of reduced erythrocyte or plasma exposure in patients at high risk for transfusion-associated circulatory overload.

  4. 30 CFR 75.518-2 - Incandescent lamps, overload and short circuit protection.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Incandescent lamps, overload and short circuit...-General § 75.518-2 Incandescent lamps, overload and short circuit protection. Incandescent lamps installed... or direct current feeder circuits, need not be provided with separate short circuit or overload...

  5. Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy.

    PubMed

    von Karstedt, Silvia; Montinaro, Antonella; Walczak, Henning

    2017-05-24

    The discovery that the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study of pro-apoptotic TRAIL receptor (TRAIL-R) signalling and the development of biotherapeutic drug candidates that activate TRAIL-Rs. The outcome of clinical trials with these TRAIL-R agonists has, however, been disappointing so far. Recent evidence indicates that many cancers, in addition to being TRAIL resistant, use the endogenous TRAIL-TRAIL-R system to their own advantage. However, novel insight on two fronts - how resistance of cancer cells to TRAIL-based pro-apoptotic therapies might be overcome, and how the pro-tumorigenic effects of endogenous TRAIL might be countered - gives reasonable hope that the TRAIL system can be harnessed to treat cancer. In this Review we assess the status quo of our understanding of the biology of the TRAIL-TRAIL-R system - as well as the gaps therein - and discuss the opportunities and challenges in effectively targeting this pathway.

  6. Magnetic and quadrupolar studies of the iron storage overload in livers

    NASA Astrophysics Data System (ADS)

    Rimbert, J. N.; Dumas, F.; Richardot, G.; Kellershohn, C.

    1986-02-01

    Absorption57Fe Mössbauer spectra, performed directly on tissues of liver with iron overload due to an excessive intestinal iron absorption or induced by hypertransfusional therapeutics, have pointed out a new high spin ferric storage iron besides the ferritin and hemosiderin. Mössbauer studies, carried out on ferritin and hemosiderin fractions isolated from normal and overloaded livers, show that this compound, only present in the secondary iron overload (transfusional pathway), seems characteristic of the physiological process which induces the iron overload.

  7. Argentine ant trail pheromone disruption is mediated by trail concentration.

    PubMed

    Suckling, David Maxwell; Stringer, Lloyd D; Corn, Joshua E

    2011-10-01

    Argentine ant trail pheromone disruption, using continuous release of the trail pheromone compound (Z)-9-hexadecanal, reduces the incidence of trails and foraging rates of field populations. However, little is known about the concentrations of pheromone required for successful disruption. We hypothesized that higher pheromone quantities would be necessary to disrupt larger ant populations. To test this, we laid a 30-cm long base trail of (Z)-9-hexadecanal on a glass surface at low and high rates (1 and 100 pg/cm) (Trail 1), and laid a second, shorter trail (Trail 2, 10 cm long, located 1.5 cm upwind) near the middle of Trail 1 at six rates (1, 10, 100, 1,000, 10,000, and 100,000 pg/cm). We then recorded and digitized movements of individual ants following Trail 1, and derived a regression statistic, r (2), as an index of trail integrity, and also recorded arrival success at the other end of the trail (30 cm) near a food supply. Disruption of trails required 100 fold more pheromone upwind, independent of base-trail concentration. This implies that in the field, trail disruption is likely to be less successful against high ant-trail densities (greater concentration of trail pheromone), and more successful against newly formed or weak trails, as could be expected along invasion fronts.

  8. Working memory overload: fronto-limbic interactions and effects on subsequent working memory function.

    PubMed

    Yun, Richard J; Krystal, John H; Mathalon, Daniel H

    2010-03-01

    The human working memory system provides an experimentally useful model for examination of neural overload effects on subsequent functioning of the overloaded system. This study employed functional magnetic resonance imaging in conjunction with a parametric working memory task to characterize the behavioral and neural effects of cognitive overload on subsequent cognitive performance, with particular attention to cognitive-limbic interactions. Overloading the working memory system was associated with varying degrees of subsequent decline in performance accuracy and reduced activation of brain regions central to both task performance and suppression of negative affect. The degree of performance decline was independently predicted by three separate factors operating during the overload condition: the degree of task failure, the degree of amygdala activation, and the degree of inverse coupling between the amygdala and dorsolateral prefrontal cortex. These findings suggest that vulnerability to overload effects in cognitive functioning may be mediated by reduced amygdala suppression and subsequent amygdala-prefrontal interaction.

  9. Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow.

    PubMed

    Shen, J C; Zhang, Y C; Zhao, M F

    2017-10-19

    Using an iron overload mouse model, we explored the protective effect of deferasirox (DFX) and N-acetyl-L-cysteine (NAC) on injured bone marrow hematopoietic stem/progenitor cells (HSPC) induced by iron overload. Mice were intraperitoneally injected with 25 mg iron dextran every 3 days for 4 weeks to establish an iron overload (Fe) model. DFX or NAC were co-administered with iron dextran in two groups of mice (Fe+DFX and Fe+NAC), and the function of HSPCs was then examined. Iron overload markedly decreased the number of murine HSPCs in bone marrow. Subsequent colony-forming cell assays showed that iron overload also decreased the colony forming capacity of HSPCs, the effect of which could be reversed by DFX and NAC. The bone marrow hematopoiesis damage caused by iron overload could be alleviated by DFX and NAC.

  10. The attenuating effect of role overload on relationships linking self-efficacy and goal level to work performance.

    PubMed

    Brown, Steven P; Jones, Eli; Leigh, Thomas W

    2005-09-01

    The reported research examines the moderating effects of role overload on the antecedents and consequences of self-efficacy and personal goal level in a longitudinal study conducted in an industrial selling context. The results indicate that role overload moderates the antecedent effect of perceived organizational resources on self-efficacy beliefs. They also show that role overload moderates the direct effects of both self-efficacy and goal level on performance, such that these relationships are positive when role overload is low but not significant when role overload is high. Further, the results reveal a pattern of moderated mediation, in which goal level mediates the indirect effect of self-efficacy on performance when role overload is low but not when it is high. Implications for theory and managerial practice are discussed. Copyright 2005 APA, all rights reserved.

  11. Evolution of Residual-Strain Distribution through an Overload-Induced Retardation Period during Fatigue Crack Growth

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lee, S. Y.; Sun, Yinan; An, Ke

    2010-01-01

    Neutron diffraction was employed to investigate the crack-growth retardation phenomenon after a single tensile overload by mapping both one-dimensional and two-dimensional residual-strain distributions around the crack tip in a series of compact-tension specimens representing various crack-growth stages through an overload-induced retardation period. The results clearly show a large compressive residual-strain field near the crack tip immediately after the overload. As the fatigue crack propagates through the overload-induced plastic zone, the compressive residual strains are gradually relaxed, and a new compressive residual-strain field is developed around the propagating crack tip, illustrating that the subsequent fatigue-induced plastic zone grows out of themore » large plastic zone caused by the overloading. The relationship between the overload-induced plastic zone and subsequent fatigue-induced plastic zone, and its influence on the residual-strain distributions in the perturbed plastic zone are discussed.« less

  12. ROS-mediated iron overload injures the hematopoiesis of bone marrow by damaging hematopoietic stem/progenitor cells in mice

    PubMed Central

    Chai, Xiao; Li, Deguan; Cao, Xiaoli; Zhang, Yuchen; Mu, Juan; Lu, Wenyi; Xiao, Xia; Li, Chengcheng; Meng, Juanxia; Chen, Jie; Li, Qing; Wang, Jishi; Meng, Aimin; Zhao, Mingfeng

    2015-01-01

    Iron overload, caused by hereditary hemochromatosis or repeated blood transfusions in some diseases, such as beta thalassemia, bone marrow failure and myelodysplastic syndrome, can significantly induce injured bone marrow (BM) function as well as parenchyma organ dysfunctions. However, the effect of iron overload and its mechanism remain elusive. In this study, we investigated the effects of iron overload on the hematopoietic stem and progenitor cells (HSPCs) from a mouse model. Our results showed that iron overload markedly decreased the ratio and clonogenic function of murine HSPCs by the elevation of reactive oxygen species (ROS). This finding is supported by the results of NAC or DFX treatment, which reduced ROS level by inhibiting NOX4 and p38MAPK and improved the long-term and multi-lineage engrafment of iron overload HSCs after transplantation. Therefore, all of these data demonstrate that iron overload injures the hematopoiesis of BM by enhancing ROS through NOX4 and p38MAPK. This will be helpful for the treatment of iron overload in patients with hematopoietic dysfunction. PMID:25970748

  13. Changes in rat muscle with compensatory overload occur in a sequential manner.

    PubMed

    Macpherson, P C; Thayer, R E; Rodgers, C; Taylor, A W; Noble, E G

    1999-01-01

    The present study was initiated to determine the time course of changes in the profile of selected skeletal muscle myofibril proteins during compensatory overload. Whole muscle isometric contractile properties were measured to assess the physiological consequences of the overload stimulus. Compensatory overload of plantaris muscle of rats was induced by surgical ablation of the synergistic soleus and gastrocnemius muscles. Myosin light chain (LC) and tropomyosin (TM) compositions of control (CP) and overloaded plantaris (OP) muscles were determined by electrophoresis and myofibrillar ATPase assays were performed to assess changes in contractile protein interactions. Within one week of overload decreases in the alpha:beta TM ratio and myofibrillar ATPase activity were observed. Following 30 days of overload, a transition in type II to type I fibres was associated with an increase in slow myosin LC1. Interestingly, after 77 days of overload, the TM subunit ratio returned to one resembling a fast twitch muscle. It is proposed that the early and transitory changes in the TM subunits of OP, as well as the rapid initial depression in maximum tetanic isometric force and myofibrillar ATPase activity may be explained as a result of muscle fibre degeneration-regeneration. We propose that alterations in protein expression induced by compensatory overload reflect both degenerative-regenerative change and increased neuromuscular activity.

  14. Role overload, pain and physical dysfunction in early rheumatoid or undifferentiated inflammatory arthritis in Canada.

    PubMed

    Mustafa, Sally Sabry; Looper, Karl Julian; Zelkowitz, Phyllis; Purden, Margaret; Baron, Murray

    2012-05-03

    Inflammatory arthritis impairs participation in societal roles. Role overload arises when the demands by a given role set exceed the resources; time and energy, to carry out the required tasks. The present study examines the association between role overload and disease outcomes in early inflammatory arthritis (EIA). Patients (n = 104) of 7.61 months mean duration of inflammatory arthritis completed self-report questionnaires on sociodemographics, disease characteristics and role overload. Pain was assessed using the Short Form McGill Pain Questionnaire (MPQ) and physical functioning was measured with the Medical Outcomes Study Short Form 36 (SF-36) physical functioning score. Role overload was measured by the Role Overload Scale. Patients indicated the number of social roles they occupied from a total of the three typical roles; marital, parental and paid work. Participants' mean age was 56 years and 70.2% were female. Role overload was not correlated to the number of social roles, however, it was positively associated with pain (p = 0.004) and negatively associated with physical functioning (p = 0.001). On multivariate analysis, role overload was negatively associated with physical functioning after controlling for the relevant sociodemographic variables. This study identifies a possible reciprocal relationship between role overload and physical functioning in patients with EIA.

  15. Clinical consequences of iron overload in patients with myelodysplastic syndromes: the case for iron chelation therapy.

    PubMed

    Shammo, Jamile M; Komrokji, Rami S

    2018-06-14

    Patients with myelodysplastic syndromes (MDS) are at increased risk of iron overload due to ineffective erythropoiesis and chronic transfusion therapy. The clinical consequences of iron overload include cardiac and/or hepatic failure, endocrinopathies, and infection risk. Areas covered: Iron chelation therapy (ICT) can help remove excess iron and ultimately reduce the clinical consequences of iron overload. The authors reviewed recent (last five years) English-language articles from PubMed on the topic of iron overload-related complications and the use of ICT (primarily deferasirox) to improve outcomes in patients with MDS. Expert Commentary: While a benefit of ICT has been more firmly established in other transfusion-dependent conditions such as thalassemia, its role in reducing iron overload in MDS remains controversial due to the lack of prospective controlled data demonstrating a survival benefit. Orally administered chelation agents (e.g., deferasirox), are now available, and observational and/or retrospective data support a survival benefit of using ICT in MDS. The placebo-controlled TELESTO trial (NCT00940602) is currently examining the use of deferasirox in MDS patients with iron overload, and is evaluating specifically whether use of ICT to alleviate iron overload can also reduce iron overload-related complications in MDS and improve survival.

  16. Fatigue History and in-situ Loading Studies of the overload Effect Using High Resolution X-ray Strain Profiling

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Croft,M.; Jisrawi, N.; Zhong, Z.

    High-energy synchrotron X-ray diffraction experiments are used to perform local crack plane strain profiling of 4140 steel compact tension specimens fatigued at constant amplitude, subjected to a single overload cycle, then fatigued some more at constant amplitude. X-ray strain profiling results on a series of samples employing in-situ load cycling are correlated with the crack growth rate (da/dN) providing insight into the da/dN retardation known as the 'overload effect'. Immediately after the overload, the strain under maximum load is greatly reduced but the range of strain, between zero and maximum load, remains unchanged compared to the pre-overload values. At themore » point of maximum retardation, it is the strain range that is greatly reduced while the maximum-load strain has begun to recover to the pre-overload value. For a sample that has recovered to approximately half of the original da/dN value following the overload, the strain at maximum load is fully recovered while the strain range, though partially recovered, is still substantially reduced. The dominance of the strain range in the overload effect is clearly indicated. Subject to some assumptions, strong quantitative support for a crack growth rate driving force of the suggested form [(K{sub max}){sup -p}({Delta}K){sup p}]{sup {gamma}} is found. A dramatic nonlinear load dependence in the spatial distribution of the strain at maximum retardation is also demonstrated: at low load the response is dominantly at the overload position; whereas at high loads it is dominantly at the crack tip position. This transfer of load response away from the crack tip to the overload position appears fundamental to the overload effect for high R-ratio fatigue as studied here.« less

  17. Enzymatically modified isoquercitrin supplementation intensifies plantaris muscle fiber hypertrophy in functionally overloaded mice.

    PubMed

    Kohara, Akiko; Machida, Masanao; Setoguchi, Yuko; Ito, Ryouichi; Sugitani, Masanori; Maruki-Uchida, Hiroko; Inagaki, Hiroyuki; Ito, Tatsuhiko; Omi, Naomi; Takemasa, Tohru

    2017-01-01

    Enzymatically modified isoquercitrin (EMIQ) is produced from rutin using enzymatic hydrolysis followed by treatment with glycosyltransferase in the presence of dextrin to add glucose residues. EMIQ is absorbed in the same way as quercetin, a powerful antioxidant reported to prevent disused muscle atrophy by targeting mitochondria and to have ergogenic effects. The present study investigated the effect of EMIQ on skeletal muscle hypertrophy induced by functional overload. In Study 1, 6-week-old ICR male mice were divided into 4 groups: sham-operated control, sham-operated EMIQ, overload-operated control, and overload-operated EMIQ groups. In Study 2, mice were divided into 3 groups: overload-operated whey control, overload-operated whey/EMIQ (low dose), and overload-operated whey/EMIQ (high dose) groups. The functional overload of the plantaris muscle was induced by ablation of the synergist (gastrocnemius and soleus) muscles. EMIQ and whey protein were administered with food. Three weeks after the operation, the cross-sectional area and minimal fiber diameter of the plantaris muscle fibers were measured. In Study 1, functional overload increased the cross-sectional area and minimal fiber diameter of the plantaris muscle. EMIQ supplementation significantly increased the cross-sectional area and minimal fiber diameter of the plantaris muscle in both the sham-operated and overload-operated groups. In Study 2, EMIQ supplementation combined with whey protein administration significantly increased the cross-sectional area and minimal fiber diameter of the plantaris muscle. EMIQ, even when administered as an addition to whey protein supplementation, significantly intensified the fiber hypertrophy of the plantaris muscle in functionally overloaded mice. EMIQ supplementation also induced fiber hypertrophy of the plantaris in sham-operated mice.

  18. Prognostic value of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors in renal cell cancer.

    PubMed

    Macher-Goeppinger, Stephan; Aulmann, Sebastian; Tagscherer, Katrin E; Wagener, Nina; Haferkamp, Axel; Penzel, Roland; Brauckhoff, Antje; Hohenfellner, Markus; Sykora, Jaromir; Walczak, Henning; Teh, Bin T; Autschbach, Frank; Herpel, Esther; Schirmacher, Peter; Roth, Wilfried

    2009-01-15

    The death ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptors (TRAIL-R) are involved in immune surveillance and tumor development. Here, we studied a possible association between the expression of TRAIL/TRAIL-Rs and the prognosis in patients with renal cell carcinomas (RCC). A tissue microarray containing RCC tumor tissue samples and corresponding normal tissue samples from 838 patients was generated. Expression of TRAIL and TRAIL-Rs was examined by immunohistochemistry and the effect of TRAIL and TRAIL-R expression on disease-specific survival was assessed. High TRAIL-R2 expression levels were associated with high-grade RCCs (P < 0.001) and correlated negatively with disease-specific survival (P = 0.01). Similarly, high TRAIL expression was associated with a shorter disease-specific survival (P = 0.01). In contrast, low TRAIL-R4 expression was associated with high-stage RCCs (P < 0.001) as well as with the incidence of distant metastasis (P = 0.03) and correlated negatively with disease-specific survival (P = 0.02). In patients without distant metastasis, multivariate Cox regression analyses revealed that TRAIL-R2 and TRAIL are independent prognostic factors for cancer-specific survival (in addition to tumor extent, regional lymph node metastasis, grade of malignancy, and type of surgery). High TRAIL-R2, high TRAIL, and low TRAIL-R4 expression levels are associated with a worse disease-specific survival in patients with RCCs. Therefore, the assessment of TRAIL/TRAIL-R expression offers valuable prognostic information that could be used to select patients for adjuvant therapy studies. Moreover, our findings are of relevance for a potential experimental therapeutic administration of TRAIL-R agonists in patients with RCCs.

  19. Volume Overload: Prevalence, Risk Factors, and Functional Outcome in Survivors of Septic Shock

    PubMed Central

    Carlbom, David; Caldwell, Ellen; Himmelfarb, Jonathan; Hough, Catherine L.

    2015-01-01

    Rationale: Survivors of septic shock have impaired functional status. Volume overload is associated with poor outcomes in patients with septic shock, but the impact of volume overload on functional outcome and discharge destination of survivors is unknown. Objectives: This study describes patterns of fluid management both during and after septic shock. We examined factors associated with volume overload upon intensive care unit (ICU) discharge. We then examined associations between volume overload upon ICU discharge, mobility limitation, and discharge to a healthcare facility in septic shock survivors, with the hypothesis that volume overload is associated with increased odds of these outcomes. Methods: We retrospectively reviewed the medical records of 247 patients admitted with septic shock to an academic county hospital between June 2009 and April 2012 who survived to ICU discharge. We defined volume overload as a fluid balance expected to increase the subject’s admission weight by 10%. Statistical methods included unadjusted analyses and multivariable logistic regression. Measurements and Main Results: Eighty-six percent of patients had a positive fluid balance, and 35% had volume overload upon ICU discharge. Factors associated with volume overload in unadjusted analyses included more severe illness, cirrhosis, blood transfusion during shock, and higher volumes of fluid administration both during and after shock. Blood transfusion during shock was independently associated with increased odds of volume overload (odds ratio [OR], 2.65; 95% confidence interval [CI], 1.33–5.27; P = 0.01) after adjusting for preexisting conditions and severity of illness. Only 42% of patients received at least one dose of a diuretic during their hospitalization. Volume overload upon ICU discharge was independently associated with inability to ambulate upon hospital discharge (OR, 2.29; 95% CI, 1.24–4.25; P = 0.01) and, in patients admitted from home, upon discharge to a healthcare facility (OR, 2.34; 95% CI, 1.1–4.98; P = 0.03). Conclusions: Volume overload is independently associated with impaired mobility and discharge to a healthcare facility in survivors of septic shock. Prevention and treatment of volume overload in patients with septic shock warrants further investigation. PMID:26394090

  20. Correlates of Trail Use for Recreation and Transportation on 5 Massachusetts Trails.

    PubMed

    Orstad, Stephanie L; McDonough, Meghan H; Klenosky, David B; Mattson, Marifran; Troped, Philip J

    2016-08-01

    Promoting use of community trails is a recommended strategy for increasing population levels of physical activity. Correlates of walking and cycling for recreation or transportation differ, though few studies have compared correlates of trail-based physical activity for recreation and transportation purposes. This study examined associations of demographic, social, and perceived built environmental factors with trail use for recreation and transportation and whether associations were moderated by age, gender, and prior trail use. Adults (N = 1195) using 1 of 5 trails in Massachusetts responded to an intercept survey. We used multiple linear and logistic regression models to examine associations with trail use. Respondents' mean age was 44.9 years (standard deviation = 12.5), 55.3% were female, and 82.0% were white. Age (longer-term users only), trail use with others, travel time to the trail, and trail design were significantly associated with use for recreation (P < .05). Age, gender, trail safety (longer-term users only), travel time to the trail, trail design (younger users only), and trail beauty were associated with use for transportation (P < .05). Some common correlates were found for recreational and transportation trail use, whereas some variables were uniquely associated with use for 1 purpose. Tailored strategies are suggested to promote trail use for recreation and transportation.

  1. Trail Transect: A Method for Documenting Trail Changes

    Treesearch

    R.E. Leonard; A.M. Whitney

    1977-01-01

    A trail transect that documents trail conditions and changes in trails has been used successfully over the past 3 years to measure soil loss, and changes in trail width and vegetation. The system also can be used to study the relationship between trail degradation and the physical characteristics of the site. Data from trail transects can be useful in determining the...

  2. Factory overload testing of a large power transformer

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Douglas, D.H.; Lawrence, C.O.; Templeton, J.B.

    1985-09-01

    A factory overload test of up to 150% of the nameplate rating was run on a 224 MVA autotransformer. The results of this test were of great value and were used in identifying transformer overload limitations, in evaluating loading guide oil and winding equations, exponents and time constants, and in helping to perfect a factory overload test procedure.

  3. Lipid Nanoparticles Decorated with TNF-Related Aptosis-Inducing Ligand (TRAIL) Are More Cytotoxic than Soluble Recombinant TRAIL in Sarcoma.

    PubMed

    Gallego-Lleyda, Ana; De Miguel, Diego; Anel, Alberto; Martinez-Lostao, Luis

    2018-05-13

    Sarcomas are rare and heterogeneous cancers classically associated with a poor outcome. Sarcomas are 1% of the cancer but recent estimations indicate that sarcomas account for 2% of the estimated cancer-related deaths. Traditional treatment with surgery, radiotherapy, and chemotherapy has improved the outcome for some types of sarcomas. However, novel therapeutic strategies to treat sarcomas are necessary. TNF-related apoptosis-inducing ligand (TRAIL) is a death ligand initially described as capable of inducing apoptosis on tumor cell while sparing normal cells. Only few clinical trials have used TRAIL-based treatments in sarcoma, but they show only low or moderate efficacy of TRAIL. Consequently, novel TRAIL formulations with an improved TRAIL bioactivity are necessary. Our group has developed a novel TRAIL formulation based on tethering this death ligand on a lipid nanoparticle surface (LUV-TRAIL) resembling the physiological secretion of TRAIL as a trasmembrane protein inserted into the membrane of exosomes. We have already demonstrated that LUV-TRAIL shows an improved cytotoxic activity when compared to soluble recombinant TRAIL both in hematological malignancies and epithelial-derived cancers. In the present study, we have tested LUV-TRAIL in several human sarcoma tumor cell lines with different sensitivity to soluble recombinant TRAIL, finding that LUV-TRAIL was more efficient than soluble recombinant TRAIL. Moreover, combined treatment of LUV-TRAIL with distinct drugs proved to be especially effective, sensitizing even more resistant cell lines to TRAIL.

  4. Differences in the impacts of formal and informal recreational trails on urban forest loss and tree structure.

    PubMed

    Ballantyne, Mark; Pickering, Catherine Marina

    2015-08-15

    Recreational trails are one of the most common types of infrastructure used for nature-based activities such as hiking and mountain biking worldwide. Depending on their design, location, construction, maintenance and use, these trails differ in their environmental impacts. There are few studies, however, comparing the impacts of different trail types including between formal management-created trails and informal visitor-created trails. Although both types of trails can be found in remote natural areas, dense networks of them often occur in forests close to cities where they experience intense visitor use. To assess the relative impacts of different recreational trails in urban forests, we compared the condition of the trail surface, loss of forest strata and changes in tree structure caused by seven types of trails (total network 46.1 km) traversing 17 remnants of an endangered urban forest in Australia. After mapping and classifying all trails, we assessed their impact on the forest condition at 125 sites (15 sites per trail type, plus 15 control sites within undisturbed forest). On the trail sites, the condition of the trail surface, distance from the trail edge to four forest strata (litter, understory, midstorey and tree cover) and structure of the tree-line were assessed. Informal trails generally had poorer surface conditions and were poorly-designed and located. Per site, formal and informal trails resulted in similar loss of forest strata, with wider trails resulting in greater loss of forest. Because there were more informal trails, however, they accounted for the greatest cumulative forest loss. Structural impacts varied, with the widest informal trails and all formal hardened trails resulting in similar reductions in canopy cover and tree density but an increase in saplings. These structural impacts are likely a function of the unregulated and intense use of large informal trails, and disturbance from the construction and maintenance of formal trails. The results demonstrate that different types of recreational trails vary in the type and range of impacts they cause to forests. They highlight the importance of careful consideration towards management options when dealing with trail networks especially in areas of high conservation value. Copyright © 2015 Elsevier Ltd. All rights reserved.

  5. SAHA-induced TRAIL-sensitisation of Multiple Myeloma cells is enhanced in 3D cell culture.

    PubMed

    Arhoma, A; Chantry, A D; Haywood-Small, S L; Cross, N A

    2017-11-15

    Multiple Myeloma (MM) is currently incurable despite many novel therapies. Tumour Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) is a potential anti-tumour agent although effects as a single agent are limited. In this study, we investigated whether the Histone Deacetylase (HDAC) inhibitor SAHA can enhance TRAIL-induced apoptosis and target TRAIL resistance in both suspension culture, and 3D cell culture as a model of disseminated MM lesions that form in bone. The effects of SAHA and/or TRAIL in 6 Multiple Myeloma cell lines were assessed in both suspension cultures and in an Alginate-based 3D cell culture model. The effect of SAHA and/or TRAIL was assessed on apoptosis by assessment of nuclear morphology using Hoechst 33342/Propidium Iodide staining. Viable cell number was assessed by CellTiter-Glo luminescence assay, Caspase-8 and -9 activities were measured by Caspase-Glo™ assay kit. TRAIL-resistant cells were generated by culture of RPMI 8226 and NCI-H929 by acute exposure to TRAIL followed by selection of TRAIL-resistant cells. TRAIL significantly induced apoptosis in a dose-dependent manner in OPM-2, RPMI 8226, NCI-H929, U266, JJN-3 MM cell lines and ADC-1 plasma cell leukaemia cells. SAHA amplified TRAIL responses in all lines except OPM-2, and enhanced TRAIL responses were both via Caspase-8 and -9. SAHA treatment induced growth inhibition that further increased in the combination treatment with TRAIL in MM cells. The co-treatment of TRAIL and SAHA reduced viable cell numbers all cell lines. TRAIL responses were further potentiated by SAHA in 3D cell culture in NCI-H929, RPMI 8226 and U266 at lower TRAIL + SAHA doses than in suspension culture. However TRAIL responses in cells that had been selected for TRAIL resistance were not further enhanced by SAHA treatment. SAHA is a potent sensitizer of TRAIL responses in both TRAIL sensitive and resistant cell lines, in both suspension and 3D culture, however SAHA did not sensitise TRAIL-sensitive cell populations that had been selected for TRAIL-resistance from initially TRAIL-sensitive populations. SAHA may increase TRAIL sensitivity in insensitive cells, but not in cells that have specifically been selected for acquired TRAIL-resistance. Copyright © 2017 Elsevier Inc. All rights reserved.

  6. Impact of iron overload on interleukin-10 levels, biochemical parameters and oxidative stress in patients with sickle cell anemia

    PubMed Central

    Barbosa, Maritza Cavalcante; dos Santos, Talyta Ellen Jesus; de Souza, Geane Félix; de Assis, Lívia Coêlho; Freitas, Max Victor Carioca; Gonçalves, Romélia Pinheiro

    2013-01-01

    Objective The aim of this study was to evaluate the impact of iron overload on the profile of interleukin-10 levels, biochemical parameters and oxidative stress in sickle cell anemia patients. Methods A cross-sectional study was performed of 30 patients with molecular diagnosis of sickle cell anemia. Patients were stratified into two groups, according to the presence of iron overload: Iron overload (n = 15) and Non-iron overload (n = 15). Biochemical analyses were performed utilizing the Wiener CM 200 automatic analyzer. The interleukin-10 level was measured by capture ELISA using the BD OptEIAT commercial kit. Oxidative stress parameters were determined by spectrophotometry. Statistical analysis was performed using GraphPad Prism software (version 5.0) and statistical significance was established for p-values < 0.05 in all analyses. Results Biochemical analysis revealed significant elevations in the levels of uric acid, triglycerides, very low-density lipoprotein (VLDL), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), urea and creatinine in the Iron overload Group compared to the Non-iron overload Group and significant decreases in the high-density lipoprotein (HDL) and low-density lipoprotein (LDL). Ferritin levels correlated positively with uric acid concentrations (p-value < 0.05). The Iron overload Group showed lower interleukin-10 levels and catalase activity and higher nitrite and malondialdehyde levels compared with the Non-iron overload Group. Conclusion The results of this study are important to develop further consistent studies that evaluate the effect of iron overload on the inflammatory profile and oxidative stress of patients with sickle cell anemia. PMID:23580881

  7. Revaluation of clinical and histological criteria for diagnosis of dysmetabolic iron overload syndrome

    PubMed Central

    Riva, Alessia; Trombini, Paola; Mariani, Raffaella; Salvioni, Alessandra; Coletti, Sabina; Bonfadini, Silvia; Paolini, Valentina; Pozzi, Matteo; Facchetti, Rita; Bovo, Giorgio; Piperno, Alberto

    2008-01-01

    AIM: To re-evaluate the diagnostic criteria of insulin resistance hepatic iron overload based on clinical, biochemical and histopathological findings. METHODS: We studied 81 patients with hepatic iron overload not explained by known genetic and acquired causes. The metabolic syndrome (MS) was defined according to ATPIII criteria. Iron overload was assessed by liver biopsy. Liver histology was evaluated by Ishak’s score and iron accumulation by Deugnier’s score; steatosis was diagnosed when present in ≥ 5% of hepatocytes. RESULTS: According to transferrin saturation levels, we observed significant differences in the amount of hepatic iron overload and iron distribution, as well as the number of metabolic abnormalities. Using Receiving Operating Curve analysis, we found that the presence of two components of the MS differentiated two groups with a statistically significant different hepatic iron overload (P < 0.0001). Patients with ≥ 2 metabolic alterations and steatosis had lower amount of hepatic iron, lower transferrin saturation and higher sinusoidal iron than patients with < 2 MS components and absence of steatosis. CONCLUSION: In our patients, the presence of ≥ 2 alterations of the MS and hepatic steatosis was associated with a moderate form of iron overload with a prevalent sinusoidal distribution and a normal transferrin saturation, suggesting the existence of a peculiar pathogenetic mechanism of iron accumulation. These patients may have the typical dysmetabolic iron overload syndrome. By contrast, patients with transferrin saturation ≥ 60% had more severe iron overload, few or no metabolic abnormalities and a hemochromatosis-like pattern of iron overload. PMID:18720534

  8. Fluid overload and survival in critically ill patients with acute kidney injury receiving continuous renal replacement therapy

    PubMed Central

    Kim, Il Young; Kim, Joo Hui; Lee, Dong Won; Lee, Soo Bong; Rhee, Harin; Seong, Eun Young; Kwak, Ihm Soo

    2017-01-01

    Background Fluid overload is known to be associated with increased mortality in patients with acute kidney injury (AKI) who are critically ill. In this study, we intended to uncover whether the adverse effect of fluid overload on survival could be applied to all of the patients with AKI who received continuous renal replacement therapy (CRRT). Methods We analyzed 341 patients with AKI who received CRRT in our intensive care units. The presence of fluid overload was defined as a minimum 10% increase in body weight from the baseline. Demographics, comorbid diseases, clinical data, severity of illness [the sequential organ failure assessment (SOFA) score, number of vasopressors, diagnosis of sepsis, use of ventilator] upon ICU admission, fluid overload status, and time elapsed from AKI diagnosis until CRRT initiation were reviewed from the medical charts. Results Patients with total fluid overload from 3 days before CRRT initiation to ICU discharge had a significantly lower survival rate after ICU admission, as compared to patients with no fluid overload (P < 0.001). Among patients with sepsis (P < 0.001) or with high SOFA scores (P < 0.001), there was a significant difference in survival of the patients with and without fluid overload. In patients without sepsis or with low SOFA score, there was no significant difference in survival of patients irrespective of fluid overload. Conclusion Our study demonstrates that the adverse effect of fluid overload on survival is more evident in patients with sepsis or with more severe illness, and that it might not apply to patients without sepsis or with less severe illness. PMID:28196107

  9. On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics

    PubMed Central

    Dimberg, Lina Y.; Anderson, Charles K.; Camidge, Ross; Behbakht, Kian; Thorburn, Andrew; Ford, Heide L.

    2015-01-01

    TRAIL and agonistic antibodies against TRAIL death receptors kill tumor cells while causing virtually no damage to normal cells. Several novel drugs targeting TRAIL receptors are currently in clinical trials. However, TRAIL resistance is a common obstacle in TRAIL based therapy and limits the efficiency of these drugs. In this review article we discuss different mechanisms of TRAIL resistance and how they can be predicted and therapeutically circumvented. In addition, we provide a brief overview of all TRAIL based clinical trials conducted so far. It is apparent that although the effects of TRAIL therapy are disappointingly modest overall, a small subset of patients responds very well to TRAIL. We argue that the true potential of targeting TRAIL death receptors in cancer can only be reached when we find efficient ways to select for those patients that are most likely to benefit from the treatment. To achieve this, it is crucial to identify biomarkers that can help us predict TRAIL sensitivity. PMID:22580613

  10. Role overload, pain and physical dysfunction in early rheumatoid or undifferentiated inflammatory arthritis in Canada

    PubMed Central

    2012-01-01

    Background Inflammatory arthritis impairs participation in societal roles. Role overload arises when the demands by a given role set exceed the resources; time and energy, to carry out the required tasks. The present study examines the association between role overload and disease outcomes in early inflammatory arthritis (EIA). Methods Patients (n = 104) of 7.61 months mean duration of inflammatory arthritis completed self-report questionnaires on sociodemographics, disease characteristics and role overload. Pain was assessed using the Short Form McGill Pain Questionnaire (MPQ) and physical functioning was measured with the Medical Outcomes Study Short Form 36 (SF-36) physical functioning score. Role overload was measured by the Role Overload Scale. Patients indicated the number of social roles they occupied from a total of the three typical roles; marital, parental and paid work. Results Participants’ mean age was 56 years and 70.2% were female. Role overload was not correlated to the number of social roles, however, it was positively associated with pain (p = 0.004) and negatively associated with physical functioning (p = 0.001). On multivariate analysis, role overload was negatively associated with physical functioning after controlling for the relevant sociodemographic variables. Conclusion This study identifies a possible reciprocal relationship between role overload and physical functioning in patients with EIA. PMID:22554167

  11. Static and Dynamic Characteristics of a Long-Span Cable-Stayed Bridge with CFRP Cables

    PubMed Central

    Xie, Xu; Li, Xiaozhang; Shen, Yonggang

    2014-01-01

    In this study, the scope of CFRP cables in cable-stayed bridges is studied by establishing a numerical model of a 1400-m span of the same. The mechanical properties and characteristics of CFRP stay cables and of a cable-stayed bridge with CFRP cables are here subjected to comprehensive analysis. The anomalies in the damping properties of free vibration, nonlinear parametric vibration and wind fluctuating vibration between steel cables and CFRP cables are determined. The structural stiffness, wind resistance and traffic vibration of the cable-stayed bridge with CFRP cables are also analyzed. It was found that the static performances of a cable-stayed bridge with CFRP cables and steel cables are basically the same. The natural frequencies of CFRP cables do not coincide with the major natural frequencies of the cable-stayed bridge, so the likelihood of CFRP cable-bridge coupling vibration is minuscule. For CFRP cables, the response amplitudes of both parametric vibration and wind fluctuating vibration are smaller than those of steel cables. It can be concluded from the research that the use of CFRP cables does not change the dynamic characteristics of the vehicle-bridge coupling vibration. Therefore, they can be used in long-span cable-stayed bridges with an excellent mechanical performance. PMID:28788710

  12. Static and Dynamic Characteristics of a Long-Span Cable-Stayed Bridge with CFRP Cables.

    PubMed

    Xie, Xu; Li, Xiaozhang; Shen, Yonggang

    2014-06-23

    In this study, the scope of CFRP cables in cable-stayed bridges is studied by establishing a numerical model of a 1400-m span of the same. The mechanical properties and characteristics of CFRP stay cables and of a cable-stayed bridge with CFRP cables are here subjected to comprehensive analysis. The anomalies in the damping properties of free vibration, nonlinear parametric vibration and wind fluctuating vibration between steel cables and CFRP cables are determined. The structural stiffness, wind resistance and traffic vibration of the cable-stayed bridge with CFRP cables are also analyzed. It was found that the static performances of a cable-stayed bridge with CFRP cables and steel cables are basically the same. The natural frequencies of CFRP cables do not coincide with the major natural frequencies of the cable-stayed bridge, so the likelihood of CFRP cable-bridge coupling vibration is minuscule. For CFRP cables, the response amplitudes of both parametric vibration and wind fluctuating vibration are smaller than those of steel cables. It can be concluded from the research that the use of CFRP cables does not change the dynamic characteristics of the vehicle-bridge coupling vibration. Therefore, they can be used in long-span cable-stayed bridges with an excellent mechanical performance.

  13. Time course of the MAPK and PI3-kinase response within 24 h of skeletal muscle overload

    NASA Technical Reports Server (NTRS)

    Carlson, C. J.; Fan, Z.; Gordon, S. E.; Booth, F. W.

    2001-01-01

    Knowledge of the molecular mechanisms by which skeletal muscle hypertrophies in response to increased mechanical loading may lead to the discovery of novel treatment strategies for muscle wasting and frailty. To gain insight into potential early signaling mechanisms associated with skeletal muscle hypertrophy, the temporal pattern of mitogen-activated protein kinase (MAPK) phosphorylation and phosphatidylinositol 3-kinase (PI3-kinase) activity during the first 24 h of muscle overload was determined in the rat slow-twitch soleus and fast-twitch plantaris muscles after ablation of the gastrocnemius muscle. p38alpha MAPK phosphorylation was elevated for the entire 24-h overload period in both muscles. In contrast, Erk 2 and p54 JNK phosphorylation were transiently increased by overload, returning to the levels of sham-operated controls by 24 h. PI3-kinase activity was increased by muscle overload only at 12 h of overload and only in the plantaris muscle. In summary, sustained elevation of p38alpha MAPK phosphorylation occurred early in response to muscle overload, identifying this pathway as a potential candidate for mediating early hypertrophic signals in response to skeletal muscle overload.

  14. Effect of anabolic steroids on overloaded and overloaded suspended skeletal muscle

    NASA Technical Reports Server (NTRS)

    Tsika, R. W.; Herrick, R. E.; Baldwin, K. M.

    1987-01-01

    The effect of treatment with an anabolic steroid (nandrolone decanoate) on the muscle mass, the subcellular protein content, and the myosin patterns of normal overloaded and suspended overloaded plantaris muscle in female rat was investigated, dividing rats into six groups: normal control (NC), overload (OV), OV steroid (OV-S), normal suspended (N-sus), OV suspended (OV-sus), and OV suspended steroid (OV-sus-S). Relative to control values, overload produced a sparing effect on the muscle weight of the OV-sus group as well as increases of muscle weight of the OV group; increased protein content; and an increased expression of slow myosin in both OV and OV-sus groups. Steroid treatment of OV animals did not after the response of any parameter analyzed for the OV group, but in the OV-sus group steroid treatment induced increases in muscle weight and in protein content of the OV-sus-S group. The treatment did not alter the pattern of isomyosin expression observed in the OV or the OV-sus groups. These result suggest that the steroid acts synergistically with functional overload only under conditions in which the effect of overload is minimized by suspension.

  15. Resources–tasks imbalance: Experiences of nurses from factors influencing workload to increase

    PubMed Central

    Khademi, Mojgan; Mohammadi, Easa; Vanaki, Zohreh

    2015-01-01

    Background: While nursing workload is a worldwide challenge, less attention has been given to the determining factors. Understanding these factors is important and could help nursing managers to provide suitable working environment and to manage the adverse outcomes of nursing workload. The aim of this study was to discover nurses’ experiences of determinant factors of their workload. Materials and Methods: In this qualitative study, the participants included 15 nurses working in two hospitals in Tehran, Iran. The data were collected through 26 unstructured interviews and were analyzed using conventional content analysis. The rigor has been guaranteed with prolonged engagement, maximum variance sampling, member check, and audit trail. Results: Resource–task imbalance was the main theme of nurses’ experiences. It means that there was an imbalance between necessary elements to meet patients’ needs in comparison with expectation and responsibility. Resource–task imbalance included lack of resource, assignment without preparation, assigning non-care tasks, and patients’ and families’ needs/expectations. Conclusions: A deep and comprehensive imbalance between recourses and tasks and expectations has been perceived by the participants to be the main source of work overload. Paying more attention to resource allocation, education of quality workforce, and job description by managers is necessary. PMID:26257804

  16. Global Variation of Meteor Trail Plasma Turbulence

    NASA Technical Reports Server (NTRS)

    Dyrud, L. P.; Hinrichs, J.; Urbina, J.

    2011-01-01

    We present the first global simulations on the occurrence of meteor trail plasma irregularities. These results seek to answer the following questions: when a meteoroid disintegrates in the atmosphere will the resulting trail become plasma turbulent, what are the factors influencing the development of turbulence, and how do they vary on a global scale. Understanding meteor trail plasma turbulence is important because turbulent meteor trails are visible as non-specular trails to coherent radars, and turbulence influences the evolution of specular radar meteor trails, particularly regarding the inference of mesospheric temperatures from trail diffusion rates, and their usage for meteor burst communication. We provide evidence of the significant effect that neutral atmospheric winds and density, and ionospheric plasma density have on the variability of meteor trail evolution and the observation of nonspecular meteor trails, and demonstrate that trails are far less likely to become and remain turbulent in daylight, explaining several observational trends using non-specular and specular meteor trails.

  17. Impact of Volume Management on Volume Overload and Rehospitalization in CAPD Patients.

    PubMed

    Xu, Yi; Yang, Shen-Min; Wang, Xiao-Hua; Wang, Hai-Fang; Niu, Mei-E; Yang, Yi-Qun; Lu, Guo-Yuan; Pang, Jian-Hong; Wang, Fei; Li, Lin

    2018-05-01

    Heart failure due to volume overload is a major reason for rehospitalization in continuous ambulatory peritoneal dialysis patients. Strict volume control provides better cardiac functions and blood pressure in this population. Volume management, which is a volume control strategy, may decrease volume overload and related complications. Using a quasi-experimental design, 66 continuous ambulatory peritoneal dialysis patients were randomly assigned to the intervention group ( n = 34) and control group ( n = 32). The patients were followed up for 6 months with scheduled clinic and/or telephone visits; the intervention group adopted volume management strategy, while the control group adopted conventional care. Volume overload and cardiac function were compared between the two groups at the baseline and at 6 months. At Month 6, the intervention group resulted in significant improvement in volume overloaded status, cardiac function, and volume-overload-related rehospitalization. Volume management strategy allows for better control of volume overload and is associated with fewer volume-related readmissions.

  18. Effect of proof testing on the flaw growth characteristics of 304 stainless steel. [crack propagation in welded joints

    NASA Technical Reports Server (NTRS)

    Finger, R. W.

    1974-01-01

    The effects of proof overload frequency and magnitude on the cyclic crack growth rates of 304 stainless steel weldments were investigated. The welding procedure employed was typical of those used on over-the-road cryogenic vessels. Tests were conducted at room temperature with an overload ratio of 1.50 to determine the effect of overload frequency. Effect of overload magnitude was determined from tests where a room temperature overload was applied between blocks of 1000 cycles applied at 78 K (-320 F). The cyclic stress level used in all tests was typical of the nominal membrane stress generally encountered in full scale vessels. Test results indicate that judicious selection of proof overload frequency and magnitude can reduce crack growth rates for cyclic stress levels.

  19. Current Review of Iron Overload and Related Complications in Hematopoietic Stem Cell Transplantation

    PubMed Central

    Atilla, Erden; Toprak, Selami K.; Demirer, Taner

    2017-01-01

    Iron overload is an adverse prognostic factor for patients undergoing hematopoietic stem cell transplantation (HSCT). In the HSCT setting, pretransplant and early posttransplant ferritin and transferrin saturation were found to be highly elevated due to high transfusion requirements. In addition to that, post-HSCT iron overload was shown to be related to infections, hepatic sinusoidal obstruction syndrome, mucositis, liver dysfunction, and acute graft-versus-host disease. Hyperferritinemia causes decreased survival rates in both pre- and posttransplant settings. Serum ferritin levels, magnetic resonance imaging, and liver biopsy are diagnostic tools for iron overload. Organ dysfunction due to iron overload may cause high mortality rates and therefore sufficient iron chelation therapy is recommended in this setting. In this review the management of iron overload in adult HSCT is discussed. PMID:27956374

  20. Associations between sociodemographic characteristics and perceptions of the built environment with the frequency, type, and duration of physical activity among trail users.

    PubMed

    Maslow, Andréa L; Reed, Julian A; Price, Anna E; Hooker, Steven P

    2012-01-01

    Rail trails are elements of the built environment that support the Task Force on Community Preventive Services' recommendation to create, or enhance access to, places for physical activity (PA). The purpose of this study was to examine the associations between sociodemographic characteristics and perceptions of the built environment with the frequency, type, and duration of PA among users of an urban, paved rail trail segment. Interviewers conducted intercept surveys with 431 rail trail users and analyzed data by using logistic regression to estimate odds ratios between sociodemographic characteristics and perceptions of the built environment on the frequency, type, and duration of PA performed on the trail. Adults who used the trail in the cool months, traveled to the trail by a motorized vehicle, used the trail with others, and had some graduate school education visited the trail less often. Younger adults, men, whites, and those with some graduate school education were more likely to engage in vigorous activities on the trail. Adults who traveled to the trail by a motorized vehicle spent more time engaged in PA on the trail. Our results suggest that the most frequent users of a rail trail for PA are those who use the trail alone and travel to the trail by bicycle or on foot. Trails are an aspect of the built environment that supports active lifestyles, and future studies should evaluate different types of trails among more diverse populations and locations.

  1. Comparing impacts between formal and informal recreational trails.

    PubMed

    Pickering, Catherine Marina; Norman, Patrick

    2017-05-15

    Globally there are hundreds of thousands of kilometres of recreational trails traversing natural areas of high conservation value: but what are their impacts and do impacts differ among trails? We compared the effects of four common types of recreational trails [(1) narrow and (2) medium width informal bare earth trails and (3) gravel and (4) tarmac/concrete formal trails] on vegetation adjacent to trails in a high conservation value plant community that is popular for mountain biking and hiking in Australia. Plant species composition was recorded in quadrats along the edge of the four types of trails and in control sites away from trails. Vegetation cover, the cover of individual growth forms, and species richness along the edges of all four types of trails were similar to the controls, although the wider trails affected plant composition, with the tarmac and gravel trails favouring different species. With very few comparative studies, more research is required to allow managers and researchers to directly compare differences in the severity and types of impacts on vegetation among trails. In the meantime, limiting damage to vegetation on the edge of hardened trails during construction, use and maintenance is important, and hardening trails may not always be appropriate. Copyright © 2016. Published by Elsevier Ltd.

  2. Immunoglobulin Fc domain fusion to TRAIL significantly prolongs its plasma half-life and enhances its antitumor activity.

    PubMed

    Wang, Haizhen; Davis, Jennifer S; Wu, Xiangwei

    2014-03-01

    TRAIL (Apo2L) is a potent inducer of cell death. Interest in TRAIL has increased, following the observation that TRAIL can selectively kill a wide variety of human cancer cells without killing normal cells both in vitro and when grown as xenografts. Therefore, TRAIL has been proposed as a promising anticancer agent and currently is being tested in clinical trials. However, recombinant TRAIL has a very short plasma half-life, which limits its therapeutic potential. To overcome this limitation, we investigated the ability of the human IgG1 fragment crystallizable region (Fc) to enhance TRAIL stability. In this report, we show that Fc-TRAIL chimeric protein displays higher specific activity in vitro and a significantly longer half-life in mice than recombinant human TRAIL (rh-TRAIL). No short-term toxicity, especially liver toxicity, was observed. More importantly, Fc-TRAIL was much more effective in inhibiting tumor growth in a xenograft tumor model compared with rh-TRAIL. Our data suggest that fusion of Fc to TRAIL is able to improve the bioavailability and activity of TRAIL both in vitro and in vivo, and Fc-TRAIL may be explored for future clinical applications in cancer treatment and prevention. ©2014 AACR.

  3. Association between thyroid hormones and TRAIL.

    PubMed

    Bernardi, Stella; Bossi, Fleur; Toffoli, Barbara; Giudici, Fabiola; Bramante, Alessandra; Furlanis, Giulia; Stenner, Elisabetta; Secchiero, Paola; Zauli, Giorgio; Carretta, Renzo; Fabris, Bruno

    2017-11-01

    Recent studies suggest that a circulating protein called TRAIL (TNF-related apoptosis-inducing ligand) might have a role in the regulation of body weight and metabolism. Interestingly, thyroid hormones seem to increase TRAIL tissue expression. This study aimed at evaluating whether overt thyroid disorders affected circulating TRAIL levels. TRAIL circulating levels were measured in euthyroid, hyperthyroid, and hypothyroid patients before and after thyroid function normalization. Univariate and multivariate analyses were performed to evaluate the correlation between thyroid hormones and TRAIL. Then, the stimulatory effect of both triiodothyronine (T3) and thyroxine (T4) on TRAIL was evaluated in vitro on peripheral blood mononuclear cells. Circulating levels of TRAIL significantly increased in hyperthyroid and decreased in hypothyroid patients as compared to controls. Once thyroid function was restored, TRAIL levels normalized. There was an independent association between TRAIL and both fT3 and fT4. Consistent with these findings, T3 and T4 stimulated TRAIL release in vitro. Here we show that thyroid hormones are associated with TRAIL expression in vivo and stimulate TRAIL expression in vitro. Given the overlap between the metabolic effects of thyroid hormones and TRAIL, this work sheds light on the possibility that TRAIL might be one of the molecules mediating thyroid hormones peripheral effects. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  4. The effect of a trail use intervention on urban trail use in Southern Nevada.

    PubMed

    Clark, Sheila; Bungum, Tim; Shan, Guogen; Meacham, Mindy; Coker, Lisa

    2014-10-01

    Communities are building or improving trail networks for biking and walking to encourage physical activity, but the relationship between trail environments and physical activity is not well understood. We examined the effect of a trail use intervention in Southern Nevada. We monitored the usage of urban trails (n=10) in Southern Nevada before, during, and after an intervention which included a marketing campaign promoting trail use and the addition of way-finding and incremental distance signage to selected trails (October 2011-October 2012). Data were collected with infrared monitors placed on the trails for three periods of 7days. We compared pre-, mid-, and post-intervention usage rates on the 6 trails where signage was added to usage rates on the 4 control trails. The groups of trails experienced different patterns of increases and decreases over the 1-year study period. Mean users per hour increased 31% for the study trails and 35% for the control trails (p<0.001), but the total increase did not vary between the groups. Trail use increased about 33% during the 1-year study period for the intervention. Adding wayfinding and incremental distance signage appeared to support the increase in usage which followed the marketing campaign. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. 47 CFR 36.153 - Assignment of Cable and Wire Facilities (C&WF) to categories.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 2 2014-10-01 2014-10-01 false Assignment of Cable and Wire Facilities (C&WF... Telecommunications Property Cable and Wire Facilities § 36.153 Assignment of Cable and Wire Facilities (C&WF) to categories. (a) Cable consists of: Aerial cable, underground cable, buried cable, submarine cable, deep sea...

  6. 47 CFR 36.153 - Assignment of Cable and Wire Facilities (C&WF) to categories.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Assignment of Cable and Wire Facilities (C&WF... Telecommunications Property Cable and Wire Facilities § 36.153 Assignment of Cable and Wire Facilities (C&WF) to categories. (a) Cable consists of: Aerial cable, underground cable, buried cable, submarine cable, deep sea...

  7. 47 CFR 36.153 - Assignment of Cable and Wire Facilities (C&WF) to categories.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Assignment of Cable and Wire Facilities (C&WF... Telecommunications Property Cable and Wire Facilities § 36.153 Assignment of Cable and Wire Facilities (C&WF) to categories. (a) Cable consists of: Aerial cable, underground cable, buried cable, submarine cable, deep sea...

  8. Reliability and Characterization of High Voltage Power Capacitors

    DTIC Science & Technology

    2014-03-01

    Cable The HVPS cable is a specialized coaxial cable that utilizes a high voltage bayonet connector. The cable itself has a voltage rating in excess...the( LabVIEW(program( GPIB( CABLE ( HVPS( HVPS( COAXIAL ( CABLE ( BNC( COAXIAL ( CABLE ( BNC( COAXIAL ( CABLE ( CAPACITOR(‘C’(DATA( CAPACITOR(‘A’(DATA( Circuit...16   F.   CABLES AND CONNECTORS ...................................................................16

  9. Hiking trails and tourism impact assessment in protected area: Jiuzhaigou Biosphere Reserve, China.

    PubMed

    Li, Wenjun; Ge, Xiaodong; Liu, Chunyan

    2005-09-01

    More and more visitors are attracted to protected areas nowadays, which not only bring about economic increase but also seriously adverse impacts on the ecological environment. In protected areas, trails are linkage between visitors and natural ecosystem, so they concentrate most of the adverse impacts caused by visitors. The trampling problems on the trails have been received attentions in the tremendous researches. However, few of them have correlated the environmental impacts to trail spatial patterns. In this project, the trails were selected as assessment objective, the trampling problems trail widening, multiple trail, and root exposure were taken as assessment indicators to assess ecological impacts in the case study area Jiuzhaigou Biosphere Reserve, and two spatial index, connectivity and circularity, were taken to indicate the trail network spatial patterns. The research results showed that the appearing frequency of the trampling problems had inverse correlation with the circularity and connectivity of the trail network, while the problem extent had no correlation with the spatial pattern. Comparing with the pristine trails, the artificial maintenance for the trails such as wooden trails and flagstone trails could prohibit vegetation root from exposure effectively. The research finds will be useful for the future trail design and tourism management.

  10. Cardiac complications in beta-thalassemia: From mice to men.

    PubMed

    Kumfu, Sirinart; Fucharoen, Suthat; Chattipakorn, Siriporn C; Chattipakorn, Nipon

    2017-06-01

    Beta-thalassemia is an inherited hemoglobin disorder caused by reduced or absent synthesis of the beta globin chains of hemoglobin. This results in variable outcomes ranging from clinically asymptomatic to severe anemia, which then typically requires regular blood transfusion. These regular blood transfusions can result in an iron overload condition. The iron overload condition can lead to iron accumulation in various organs, especially in the heart, leading to iron overload cardiomyopathy, which is the major cause of mortality in patients with thalassemia. In the past decades, there is no doubt that the use of β-thalassemic mice as a study model to investigate the pathophysiology of iron overload cardiomyopathy and the role of various pharmacological interventions, has shed some light in understanding this serious complication and in improving the associated cardiac dysfunction. In this review, the effects that iron overload has on the hearts of β-thalassemic mice under conditions of iron overload as well as the efficacy of pharmacological interventions to combat these adverse effects on the heart are reviewed and discussed. The in-depth understanding of biomolecular alterations in the heart of these iron overload thalassemic mice will help give guidance for more effective therapeutic approaches in the near future. Impact statement Iron overload cardiomyopathy is a major cause of morbidity and mortality in patients with thalassemia. Since investigation of iron overload cardiomyopathy in thalassemia patients has many limitations, a search for an animal model for this condition has been ongoing for decades. In the past decades, there is no doubt that the use of β-thalassemic mice as a study model to investigate the pathophysiology of iron overload cardiomyopathy and the role of various pharmacological interventions, has shed some light in understanding this serious complication and in improving the associated cardiac dysfunction. In this review, the effects of iron overload on the hearts of β-thalassemic mice under conditions of iron overload as well as the efficacy of pharmacological interventions to combat these adverse effects on the heart are reviewed and discussed.

  11. Cardiac complications in beta-thalassemia: From mice to men

    PubMed Central

    Kumfu, Sirinart; Fucharoen, Suthat; Chattipakorn, Siriporn C.

    2017-01-01

    Beta-thalassemia is an inherited hemoglobin disorder caused by reduced or absent synthesis of the beta globin chains of hemoglobin. This results in variable outcomes ranging from clinically asymptomatic to severe anemia, which then typically requires regular blood transfusion. These regular blood transfusions can result in an iron overload condition. The iron overload condition can lead to iron accumulation in various organs, especially in the heart, leading to iron overload cardiomyopathy, which is the major cause of mortality in patients with thalassemia. In the past decades, there is no doubt that the use of β-thalassemic mice as a study model to investigate the pathophysiology of iron overload cardiomyopathy and the role of various pharmacological interventions, has shed some light in understanding this serious complication and in improving the associated cardiac dysfunction. In this review, the effects that iron overload has on the hearts of β-thalassemic mice under conditions of iron overload as well as the efficacy of pharmacological interventions to combat these adverse effects on the heart are reviewed and discussed. The in-depth understanding of biomolecular alterations in the heart of these iron overload thalassemic mice will help give guidance for more effective therapeutic approaches in the near future. Impact statement Iron overload cardiomyopathy is a major cause of morbidity and mortality in patients with thalassemia. Since investigation of iron overload cardiomyopathy in thalassemia patients has many limitations, a search for an animal model for this condition has been ongoing for decades. In the past decades, there is no doubt that the use of β-thalassemic mice as a study model to investigate the pathophysiology of iron overload cardiomyopathy and the role of various pharmacological interventions, has shed some light in understanding this serious complication and in improving the associated cardiac dysfunction. In this review, the effects of iron overload on the hearts of β-thalassemic mice under conditions of iron overload as well as the efficacy of pharmacological interventions to combat these adverse effects on the heart are reviewed and discussed. PMID:28485683

  12. Research for the development of best management practices for minimizing horse trail impacts on the Hoosier National Forest

    USGS Publications Warehouse

    Aust, M.W.; Marion, J.L.; Kyle, K.

    2005-01-01

    This research investigates horse trail impacts to gain an improved understanding of the relationship between various levels of horse use, horse trail management alternatives, and subsequent horse trail degradation. A survey of existing horse trails on the Hoosier National Forest was used to collect data on use-related, environmental and management factors to model horse trail impacts. Results are analyzed to identify which factors are most easily manipulated by managers to effectively avoid and minimize horse trail impacts. A specific focus includes evaluating the relative effect of trail use level, surfacing, grade, and water control on indices of erosion and trafficability such as trail cross sectional area, estimated erosion, muddiness, and incision. Overall, the Hoosier National Forest horse trails could be significantly improved by relocating or closing inherited trails that directly ascend slope or are excessively steep, reducing the distance between water control structures, and by applying gravel to harden trail surfaces and reduce soil erosion. A set of Best Management Practices for trails are included as a product of this work, with recommendations based on this research.

  13. Trail impacts and trail impact management related to ecotourism visitation at Torres del Paine National Park, Chile

    USGS Publications Warehouse

    Farrell, T.A.; Marion, J.L.

    2002-01-01

    Ecotourism and protected area visitation in Central and South America are largely dependent upon a relatively undisturbed quality of natural resources. However, visitation may impact vegetation, soil, water and wildlife resources, and degrade visitor facilities such as recreation sites and trails. Findings are reported from trail impact research conducted at Torres del Paine National Park in Patagonia, Chile. The frequency and magnitude of selected trail impacts and the relative effect of the amount of use, vegetation type, trail position and trail grade are investigated. Findings differed from previous studies in that amount of use was significantly related to both trail width increases and trail erosion. Management actions to minimize trail impacts are offered.

  14. Specificity of laboratory trail following by the argentine ant,Iridomyrmex humilis (Mayr), to (Z)-9-hexadecenal, analogs, and gaster extract.

    PubMed

    Van Vorhis Key, S E; Baker, T C

    1982-07-01

    In laboratory trail-following bioassays of Argentine ant workers,Iridomyrmex humilis (Mayr), the geometric isomer, (E)-9-hexadecenal, of the trail pheromone component (Z)-9-hexadecenal elicited insignificant trail following as did the potentially more stable formate analogs, (Z)-7-tetradecenyl formate, (E)-7-tetradecenyl formate, and tetradecyl formate. Further, in direct choice tests, workers showed no preference for gaster extract trails (0.002 ant equiv/cm) over trails of (Z)-9-hexadecenal (0.2 ng/cm). Moreover, a 10-fold increase in synthetic trail concentration to 2.0 ng/cm caused (Z)-9-hexadecenal trails to be significantly preferred over gaster extract trails by trail-following ants.

  15. Modeling vibration response and damping of cables and cabled structures

    NASA Astrophysics Data System (ADS)

    Spak, Kaitlin S.; Agnes, Gregory S.; Inman, Daniel J.

    2015-02-01

    In an effort to model the vibration response of cabled structures, the distributed transfer function method is developed to model cables and a simple cabled structure. The model includes shear effects, tension, and hysteretic damping for modeling of helical stranded cables, and includes a method for modeling cable attachment points using both linear and rotational damping and stiffness. The damped cable model shows agreement with experimental data for four types of stranded cables, and the damped cabled beam model shows agreement with experimental data for the cables attached to a beam structure, as well as improvement over the distributed mass method for cabled structure modeling.

  16. Curcumin Attenuates Iron Accumulation and Oxidative Stress in the Liver and Spleen of Chronic Iron-Overloaded Rats

    PubMed Central

    Badria, Farid A.; Ibrahim, Ahmed S.; Badria, Adel F.; Elmarakby, Ahmed A.

    2015-01-01

    Objectives Iron overload is now recognized as a health problem in industrialized countries, as excessive iron is highly toxic for liver and spleen. The potential use of curcumin as an iron chelator has not been clearly identified experimentally in iron overload condition. Here, we evaluate the efficacy of curcumin to alleviate iron overload-induced hepatic and splenic abnormalities and to gain insight into the underlying mechanisms. Design and Methods Three groups of male adult rats were treated as follows: control rats, rats treated with iron in a drinking water for 2 months followed by either vehicle or curcumin treatment for 2 more months. Thereafter, we studied the effects of curcumin on iron overload-induced lipid peroxidation and anti-oxidant depletion. Results Treatment of iron-overloaded rats with curcumin resulted in marked decreases in iron accumulation within liver and spleen. Iron-overloaded rats had significant increases in malonyldialdehyde (MDA), a marker of lipid peroxidation and nitric oxide (NO) in liver and spleen when compared to control group. The effects of iron overload on lipid peroxidation and NO levels were significantly reduced by the intervention treatment with curcumin (P<0.05). Furthermore, the endogenous anti-oxidant activities/levels in liver and spleen were also significantly decreased in chronic iron overload and administration of curcumin restored the decrease in the hepatic and splenic antioxidant activities/levels. Conclusion Our study suggests that curcumin may represent a new horizon in managing iron overload-induced toxicity as well as in pathological diseases characterized by hepatic iron accumulation such as thalassemia, sickle cell anemia, and myelodysplastic syndromes possibly via iron chelation, reduced oxidative stress derived lipid peroxidation and improving the body endogenous antioxidant defense mechanism. PMID:26230491

  17. TRAIL-coated lipid-nanoparticles overcome resistance to soluble recombinant TRAIL in non-small cell lung cancer cells

    NASA Astrophysics Data System (ADS)

    De Miguel, Diego; Gallego-Lleyda, Ana; María Ayuso, José; Erviti-Ardanaz, Sandra; Pazo-Cid, Roberto; del Agua, Celia; José Fernández, Luis; Ochoa, Ignacio; Anel, Alberto; Martinez-Lostao, Luis

    2016-05-01

    Purpose. Non-small cell lung cancer (NSCLC) is one the types of cancer with higher prevalence and mortality. Apo2-Ligand/TRAIL is a TNF family member able to induce apoptosis in tumor cells but not in normal cells. It has been tested in clinical trials against different types of human cancer including NSCLC. However, results of clinical trials have shown a limited efficacy of TRAIL-based therapies. Recently we have demonstrated that artificial lipid nanoparticles coated with bioactive Apo2L/TRAIL (LUV-TRAIL) greatly improved TRAIL cytotoxic ability being capable of killing chemoresistant hematological cancer cells. In the present work we have extended the study to NSCLC. Methods/patients. LUV-TRAIL-induced cytotoxicity was assessed on different NSCLC cell lines with different sensitivity to soluble TRAIL and on primary human tumor cells from three patients suffering from NSCLC cancer. We also tested LUV-TRAIL-cytotoxic ability in combination with several anti-tumor agents. Results. LUV-TRAIL exhibited a greater cytotoxic effect compared to soluble TRAIL both in A549 cells and primary human NSCLC cells. LUV-TRAIL-induced cell death was dependent on caspase-8 and caspase-3 activation. Moreover, combination of LUV-TRAIL with other anti-tumor agents such as flavopiridol, and SNS-032 clearly enhanced LUV-TRAIL-induced cytotoxicity against NSCLC cancer cells. Conclusion. The novel formulation of TRAIL based on displaying it on the surface of lipid nanoparticles greatly increases its anti-tumor activity and has clinical potential in cancer treatment.

  18. Characteristics of physical activity levels among trail users in a U.S. national sample.

    PubMed

    Librett, John J; Yore, Michelle M; Schmid, Thomas L

    2006-11-01

    The Task Force on Community Preventive Services strongly recommends environmental interventions that include enhanced access to opportunities for physical activity, such as walking and cycling trails. Although accumulating evidence indicates that trails can be effective in increasing physical activity, little is known about trail users. Cross-sectional analysis of a national sample of 3717 adults from the HealthStyles and ConsumerStyles surveys using logistic regression to determine physical activity patterns and sociodemographic correlates related to trail use, and to identify support regarding trail development policies. Almost 13% (12.7%) of the sample reported using trails at least once a month and 24.3% at least once a week. People who reported using trails at least once a week were twice as likely than people who reported rarely or never using trails to meet physical activity recommendations (odds ratio=2.3, 95% confidence interval=1.9-2.8). Nearly half (43.6%) of the non-trail users supported expanded public spaces for people to exercise, and 36.4% of the non-trail users reported that they would be willing to pay more taxes to build more parks and trails in their community. Community trails facilitate physical activity, and almost half of frequent trail users report that access to trails and other green space is important in choosing a place to live. These results support the need for prospective research on whether newly built trails promote physical activity in previously inactive people.

  19. TRAIL-coated lipid-nanoparticles overcome resistance to soluble recombinant TRAIL in non-small cell lung cancer cells.

    PubMed

    De Miguel, Diego; Gallego-Lleyda, Ana; Ayuso, José María; Erviti-Ardanaz, Sandra; Pazo-Cid, Roberto; del Agua, Celia; Fernández, Luis José; Ochoa, Ignacio; Anel, Alberto; Martinez-Lostao, Luis

    2016-05-06

    Non-small cell lung cancer (NSCLC) is one the types of cancer with higher prevalence and mortality. Apo2-Ligand/TRAIL is a TNF family member able to induce apoptosis in tumor cells but not in normal cells. It has been tested in clinical trials against different types of human cancer including NSCLC. However, results of clinical trials have shown a limited efficacy of TRAIL-based therapies. Recently we have demonstrated that artificial lipid nanoparticles coated with bioactive Apo2L/TRAIL (LUV-TRAIL) greatly improved TRAIL cytotoxic ability being capable of killing chemoresistant hematological cancer cells. In the present work we have extended the study to NSCLC. LUV-TRAIL-induced cytotoxicity was assessed on different NSCLC cell lines with different sensitivity to soluble TRAIL and on primary human tumor cells from three patients suffering from NSCLC cancer. We also tested LUV-TRAIL-cytotoxic ability in combination with several anti-tumor agents. LUV-TRAIL exhibited a greater cytotoxic effect compared to soluble TRAIL both in A549 cells and primary human NSCLC cells. LUV-TRAIL-induced cell death was dependent on caspase-8 and caspase-3 activation. Moreover, combination of LUV-TRAIL with other anti-tumor agents such as flavopiridol, and SNS-032 clearly enhanced LUV-TRAIL-induced cytotoxicity against NSCLC cancer cells. The novel formulation of TRAIL based on displaying it on the surface of lipid nanoparticles greatly increases its anti-tumor activity and has clinical potential in cancer treatment.

  20. Melatonin protects bone marrow mesenchymal stem cells against iron overload-induced aberrant differentiation and senescence.

    PubMed

    Yang, Fan; Yang, Lei; Li, Yuan; Yan, Gege; Feng, Chao; Liu, Tianyi; Gong, Rui; Yuan, Ye; Wang, Ning; Idiiatullina, Elina; Bikkuzin, Timur; Pavlov, Valentin; Li, Yang; Dong, Chaorun; Wang, Dawei; Cao, Yang; Han, Zhenbo; Zhang, Lai; Huang, Qi; Ding, Fengzhi; Bi, Zhengang; Cai, Benzhi

    2017-10-01

    Bone marrow mesenchymal stem cells (BMSCs) are an expandable population of stem cells which can differentiate into osteoblasts, chondrocytes and adipocytes. Dysfunction of BMSCs in response to pathological stimuli contributes to bone diseases. Melatonin, a hormone secreted from pineal gland, has been proved to be an important mediator in bone formation and mineralization. The aim of this study was to investigate whether melatonin protected against iron overload-induced dysfunction of BMSCs and its underlying mechanisms. Here, we found that iron overload induced by ferric ammonium citrate (FAC) caused irregularly morphological changes and markedly reduced the viability in BMSCs. Consistently, osteogenic differentiation of BMSCs was significantly inhibited by iron overload, but melatonin treatment rescued osteogenic differentiation of BMSCs. Furthermore, exposure to FAC led to the senescence in BMSCs, which was attenuated by melatonin as well. Meanwhile, melatonin was able to counter the reduction in cell proliferation by iron overload in BMSCs. In addition, protective effects of melatonin on iron overload-induced dysfunction of BMSCs were abolished by its inhibitor luzindole. Also, melatonin protected BMSCs against iron overload-induced ROS accumulation and membrane potential depolarization. Further study uncovered that melatonin inhibited the upregulation of p53, ERK and p38 protein expressions in BMSCs with iron overload. Collectively, melatonin plays a protective role in iron overload-induced osteogenic differentiation dysfunction and senescence through blocking ROS accumulation and p53/ERK/p38 activation. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  1. A Pre-ionization System to Limit Neutral Gas in a Compact Toroid Injector

    NASA Astrophysics Data System (ADS)

    Allfrey, Ian; Roche, Thomas; Matsumoto, Tadafumi; Garate, Eusebio; Gota, Hiroshi; Asai, Tomohiko; the TAE Team

    2016-10-01

    Fusion plasmas require long lifetimes and high temperatures, both of which are limited by particle loss, among other factors. Therefore, refueling a long-lived advanced beam-driven field-reversed configuration (FRC) plasma in C-2U is necessary, and injecting a supersonic compact toroid (CT) is an effective means of introducing particles into the FRC core. However, neutral gas that trails the CT into the target chamber cools the FRC. Pre-ionization (PI) system assists the break down between electrodes of the CT injector (CTI), so the amount of introduced gas can be lowered by up to a factor of two, effectively increasing the ionization fraction; thus, reducing the amount of neutral gas in the system. Additionally, the PI decreases the delay in CTI breakdown so a highly reproducible operation is achievable. The PI system consists of a fast, high voltage, pulse discharge circuit coupled to a Teflon insulated semi-rigid coaxial cable inserted into the CTI. System details and experimental data will be presented, in addition to issues such as the introduction of impurities and pre-ionizer lifetime.

  2. ANG II is required for optimal overload-induced skeletal muscle hypertrophy

    NASA Technical Reports Server (NTRS)

    Gordon, S. E.; Davis, B. S.; Carlson, C. J.; Booth, F. W.

    2001-01-01

    ANG II mediates the hypertrophic response of overloaded cardiac muscle, likely via the ANG II type 1 (AT(1)) receptor. To examine the potential role of ANG II in overload-induced skeletal muscle hypertrophy, plantaris and/or soleus muscle overload was produced in female Sprague-Dawley rats (225-250 g) by the bilateral surgical ablation of either the synergistic gastrocnemius muscle (experiment 1) or both the gastrocnemius and plantaris muscles (experiment 2). In experiment 1 (n = 10/group), inhibiting endogenous ANG II production by oral administration of an angiotensin-converting enzyme (ACE) inhibitor during a 28-day overloading protocol attenuated plantaris and soleus muscle hypertrophy by 57 and 96%, respectively (as measured by total muscle protein content). ACE inhibition had no effect on nonoverloaded (sham-operated) muscles. With the use of new animals (experiment 2; n = 8/group), locally perfusing overloaded soleus muscles with exogenous ANG II (via osmotic pump) rescued the lost hypertrophic response in ACE-inhibited animals by 71%. Furthermore, orally administering an AT(1) receptor antagonist instead of an ACE inhibitor produced a 48% attenuation of overload-induced hypertrophy that could not be rescued by ANG II perfusion. Thus ANG II may be necessary for optimal overload-induced skeletal muscle hypertrophy, acting at least in part via an AT(1) receptor-dependent pathway.

  3. Studies on deflection area vectors of QRS and T and ventricular gradient in right ventricular hypertrophy.

    PubMed

    Kawaguchi, Y

    1985-04-01

    QRS deflection area vector (Aqrs), T deflection area vector (At) and ventricular gradient (G) in right ventricular hypertrophy were studied in 53 subjects divided on the basis of cardiac catheterization data into four subgroups; normal controls, mild MS group, right ventricular pressure overload group and right ventricular volume overload group. Aqrs, At and G of the four subgroups were calculated using a microcomputer and compared. Aqrs in right ventricular pressure overload group and volume overload group was shifted to the right and slightly anteriorly from that in normal control group. At in right ventricular pressure overload group and volume overload group was shifted slightly upwards and significantly posteriorly from that in the normal control and mild MS groups. G in right ventricular pressure overload group and volume overload group was shifted to the right and significantly posteriorly from that in normal control and mild MS groups. Using multivariative analysis, we developed criteria for diagnosing right ventricular hypertrophy with At: 0.059At(Z) - 0.0145 [At] - 0.2608 less than or equal to 0. Application of this criteria achieved 82.4% (28 of 34) sensitivity in the patients with right ventricular hypertrophy and 90.9% (10 of 11) specificity in the normal control subjects.

  4. Non-HFE iron overload as a surrogate marker of disease severity in patients of liver cirrhosis.

    PubMed

    Noor, Mohd Talha; Tiwari, Manish; Kumar, Ravindra

    2016-01-01

    Decompensated liver cirrhosis is an important cause of mortality worldwide. Various modifiable and non-modifiable factors are involved in the pathogenesis of cirrhosis and its complications. This study was aimed to evaluate the association of iron overload and disease severity in patients of liver cirrhosis and its association with HFE gene mutation. Forty-nine patients with decompensated liver cirrhosis were recruited. Clinical and laboratory parameters were compared in patients with and without iron overload. C282Y and H63D gene mutation analysis was performed in all patients with iron overload. Iron overload was found in 20 (40.82%) patients. A significant positive correlation of transferrin saturation with Child-Turcotte-Pugh (CTP) score (r = 0.705, p < 0.001) and model for end-stage liver disease (MELD) score (r = 0.668, p < 0.001) was found. Transferrin saturation was also independently associated with high CTP and MELD score on multivariate analysis. Mortality over 3 months was significantly more common in iron-overloaded patients (p = 0.028). C282Y homozygosity or C282Y/H63D compound heterozygosity was not found in any of the patients with iron overload. Iron overload was significantly associated with disease severity and reduced survival in patients of decompensated liver cirrhosis.

  5. 77 FR 39733 - Proposed Information Collection; Comment Request: Appalachian Trail Management Partner Survey

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... Collection; Comment Request: Appalachian Trail Management Partner Survey AGENCY: National Park Service (NPS... the Appalachian Trail Park Office (ATPO) to protect trail resources and provide for the public enjoyment and visitor experience of the Appalachian National Scenic Trail (Trail). To comply with the...

  6. 36 CFR 212.21 - Pacific Crest National Scenic Trail.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Trail. 212.21 Section 212.21 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF... National Scenic Trail. The Pacific Crest National Scenic Trail as defined by the National Trails Systems Act, 82 Stat. 919, shall be administered primarily as a footpath and horseback riding trail by the...

  7. Targeting Death Receptor TRAIL-R2 by Chalcones for TRAIL-Induced Apoptosis in Cancer Cells

    PubMed Central

    Szliszka, Ewelina; Jaworska, Dagmara; Kłósek, Małgorzata; Czuba, Zenon P.; Król, Wojciech

    2012-01-01

    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in cancer cells without toxicity to normal cells. TRAIL binds to death receptors, TRAIL-R1 (DR4) and TRAIL-R2 (DR5) expressed on cancer cell surface and activates apoptotic pathways. Endogenous TRAIL plays an important role in immune surveillance and defense against cancer cells. However, as more tumor cells are reported to be resistant to TRAIL mediated death, it is important to search for and develop new strategies to overcome this resistance. Chalcones can sensitize cancer cells to TRAIL-induced apoptosis. We examined the cytotoxic and apoptotic effects of TRAIL in combination with four chalcones: chalcone, isobavachalcone, licochalcone A and xanthohumol on HeLa cancer cells. The cytotoxicity was measured by MTT and LDH assays. The apoptosis was detected using annexin V-FITC staining by flow cytometry and fluorescence microscopy. Death receptor expression was analyzed using flow cytometry. The decreased expression of death receptors in cancer cells may be the cause of TRAIL-resistance. Chalcones enhance TRAIL-induced apoptosis in HeLa cells through increased expression of TRAIL-R2. Our study has indicated that chalcones augment the antitumor activity of TRAIL and confirm their cancer chemopreventive properties. PMID:23203129

  8. [Current understanding of iron overload hazard in patients with myelodysplastic syndrome].

    PubMed

    Song, Lu-Xi; Su, Ji-Ying; Zhang, Zhen; Chang, Chun-Kang

    2013-04-01

    Patients with myelodysplastic syndromes (MDS) become dependent on blood transfusions and develop into transfusional iron overload, which is exacerbated by increased absorption of dietary iron in response to ineffective erythropoiesis. However, it is uncertain whether there is an association among iron accumulation, clinical complications, and decreased likelihood of survival in MDS patients. Thereby our current understanding of the effects of transfusion dependency and iron overload in MDS are discussed. Particular emphasis should be placed on further characterizing the role of redox-active forms of labile iron and oxidative stress in iron overload, decreased life expectancy and increased risk of leukemic transformation in MDS patients with iron overload.

  9. The analysis of cable forces based on natural frequency

    NASA Astrophysics Data System (ADS)

    Suangga, Made; Hidayat, Irpan; Juliastuti; Bontan, Darwin Julius

    2017-12-01

    A cable is a flexible structural member that is effective at resisting tensile forces. Cables are used in a variety of structures that employ their unique characteristics to create efficient design tension members. The condition of the cable forces in the cable supported structure is an important indication of judging whether the structure is in good condition. Several methods have been developed to measure on site cable forces. Vibration technique using correlation between natural frequency and cable forces is a simple method to determine in situ cable forces, however the method need accurate information on the boundary condition, cable mass, and cable length. The natural frequency of the cable is determined using FFT (Fast Fourier Transform) Technique to the acceleration record of the cable. Based on the natural frequency obtained, the cable forces then can be determine by analytical or by finite element program. This research is focus on the vibration techniques to determine the cable forces, to understand the physical parameter effect of the cable and also modelling techniques to the natural frequency and cable forces.

  10. Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cells.

    PubMed

    Kim, Seok-Hyun; Kim, Kunhong; Kwagh, Jae G; Dicker, David T; Herlyn, Meenhard; Rustgi, Anil K; Chen, Youhai; El-Deiry, Wafik S

    2004-09-17

    The cytotoxic death ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a tumor-specific agent under development as a novel anticancer therapeutic agent. However, some reports have demonstrated toxicity of certain TRAIL preparations toward human hepatocytes and keratinocytes through a caspase-dependent mechanism that involves activation of the extrinsic death pathway and Type II signaling through the mitochondria. We have isolated and purified both His-tagged protein and three versions of native recombinant human TRAIL protein from Escherichia coli. We found that 5 mm dithiothreitol in the purification process enhanced oligomerization of TRAIL and resulted in the formation of hyper-oligomerized TRAILs, including hexamers and nonomers with an extremely high potency in apoptosis induction. Although death-inducing signaling complex formation was much more efficient in cells treated with hyper-oligomerized TRAILs, this did not convert TRAIL-sensitive Type II HCT116 colon tumor cells to a Type I death pattern as judged by their continued sensitivity to a caspase 9 inhibitor. Moreover, TRAIL-resistant Type II Bax-null colon carcinoma cells were not converted to a TRAIL-sensitive Type I state by hyper-oligomerized TRAIL. Primary human esophageal epithelial 2 cells were found to be sensitive to all TRAIL preparations used, including trimer TRAIL. TRAIL-induced death in esophageal epithelial 2 cells was prevented by caspase 9 inhibition for up to 4 h after TRAIL exposure. This result suggests a possible therapeutic application of caspase 9 inhibition as a strategy to reverse TRAIL toxicity. Hyper-oligomerized TRAIL may be considered as an alternative agent for testing in clinical trials.

  11. TRAIL Death Receptor-4 Expression Positively Correlates With the Tumor Grade in Breast Cancer Patients With Invasive Ductal Carcinoma

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sanlioglu, Ahter D.; Department of Medical Biology and Genetics, Akdeniz University Faculty of Medicine, Antalya; Korcum, Aylin F.

    2007-11-01

    Purpose: Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) selectively induces apoptosis in cancer cells but not in normal cells, and a number of clinical trials have recently been initiated to test the safety and antitumoral potential of TRAIL in cancer patients. Four different receptors have been identified to interact with TRAIL: two are death-inducing receptors (TRAIL-R1 [DR4] and TRAIL-R2 [DR5]), whereas the other two (TRAIL-R3 [DcR1] and TRAIL-R4 [DcR2]) do not induce death upon ligation and are believed to counteract TRAIL-induced cytotoxicity. Because high levels of DcR2 expression have recently been correlated with carcinogenesis in the prostate and lung, thismore » study investigated the importance of TRAIL and TRAIL receptor expression in breast cancer patients with invasive ductal carcinoma, taking various prognostic markers into consideration. Methods and Materials: Immunohistochemical analyses were performed on 90 breast cancer patients with invasive ductal carcinoma using TRAIL and TRAIL receptor-specific antibodies. Age, menopausal status, tumor size, lymph node status, tumor grade, lymphovascular invasion, perineural invasion, extracapsular tumor extension, presence of an extensive intraductal component, multicentricity, estrogen and progesterone receptor status, and CerbB2 expression levels were analyzed with respect to TRAIL/TRAIL receptor expression patterns. Results: The highest TRAIL receptor expressed in patients with invasive ductal carcinoma was DR4. Although progesterone receptor-positive patients exhibited lower DR5 expression, CerbB2-positive tissues displayed higher levels of both DR5 and TRAIL expressions. Conclusions: DR4 expression positively correlates with the tumor grade in breast cancer patients with invasive ductal carcinoma.« less

  12. Direct observation of the residual plastic deformation caused by a single tensile overload

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bichler, C.; Pippan, R.

    1999-07-01

    The fatigue crack growth behavior following single tensile overloads at high stress intensity ranges in a cold-rolled austenitic steel has been studied experimentally. After tensile overloads, fatigue cracks initially accelerate, followed by significant retardation, before the growth rates return to their baseline level. The initial acceleration was attributed to an immediate reduction in near-tip closure. Scanning electron micrography and stereophotogrammetric reconstruction of the fracture surface were applied to study the residual plastic deformation caused by a single tensile overload in the mid-thickness of the specimen. The measured residual opening displacement of the crack as a function of the overload ismore » presented and compared with simple estimations. Also, free specimen surface observations of the residual plastic deformation and crack growth rate were performed. In the midsection of the specimens the striation spacing-length, i.e., the microscopic growth rates, were measured before and after the applied overload. It will be shown that the measured plasticity-induced wedges from the single overload and the observed propagation behavior support the significance of the concept of crack closure.« less

  13. Myelodysplastic syndromes and the role of iron overload.

    PubMed

    Harvey, R Donald

    2010-04-01

    The epidemiology of myelodysplastic syndromes (MDS) and iron overload, recent clinical findings that highlight the importance of actively managing iron overload, and recommendations for initiating and maintaining iron chelation therapy (ICT) are summarized. MDS are a variety of hematological disorders with differing time courses. Disease morbidities are primarily due to cytopenias and evolution to acute myeloid leukemia. Iron overload is a serious complication in patients with MDS due to the long-term use of red blood cell transfusions in patients with symptomatic anemia. Clinical consequences of iron overload include end-organ damage and dysfunction, an increased frequency of transplant-related complications, and reduced survival rates. To prevent these complications, recommendations for initiating and maintaining ICT should be followed by clinicians caring for patients with MDS and iron overload. As current therapeutic options for patients with MDS do not always reduce the transfusion burden, many patients will still need long-term transfusion therapy. Strategies for the management of iron overload in MDS should be considered early in the disease course and in appropriate patients in order to prevent negative clinical outcomes associated with excessive iron accumulation.

  14. Trails and physical activity: a review.

    PubMed

    Starnes, Heather A; Troped, Philip J; Klenosky, David B; Doehring, Angela M

    2011-11-01

    To provide a synthesis of research on trails and physical activity from the public health, leisure sciences, urban planning, and transportation literatures. A search of databases was conducted to identify studies published between 1980 and 2008. 52 studies were identified. The majority were cross-sectional (92%) and published after 1999 (77%). The evidence for the effects of trails on physical activity was mixed among 3 intervention and 5 correlational studies. Correlates of trail use were examined in 13 studies. Several demographic (eg, race, education, income) and environmental factors (eg, land-use mix and distance to trail) were related to trail use. Evidence from 31 descriptive studies identified several facilitators and barriers to trail use. Economic studies (n = 5) examining trails in terms of health or recreational outcomes found trails are cost-effective and produce significant economic benefits. There is a growing body of evidence demonstrating important factors that should be considered in promoting trail use, yet the evidence for positive effects of trails on physical activity is limited. Further research is needed to evaluate the effects of trails on physical activity. In addition, trail studies that include children and youth, older adults, and racial and ethnic minorities are a research priority.

  15. Photo-excitable hybrid nanocomposites for image-guided photo/TRAIL synergistic cancer therapy.

    PubMed

    Lin, Gan; Zhang, Yang; Zhu, Congqing; Chu, Chengchao; Shi, Yesi; Pang, Xin; Ren, En; Wu, Yayun; Mi, Peng; Xia, Haiping; Chen, Xiaoyuan; Liu, Gang

    2018-05-22

    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce apoptosis in cancer cells without toxicity to normal cells. However, the efficiency is greatly limited by its short half-life and wild resistance in various cancer cells. In this study, we reported a micellar hybrid nanoparticle to carry TRAIL ligand (denoted as IPN@TRAIL) for a novel photo-excited TRAIL therapy. These IPN@TRAIL offered increased TRAIL stability, prolonged half-life and enhanced tumor accumulation, monitored by dual mode imaging. Furthermore, IPN@TRAIL nanocomposites enhanced wrapped TRAIL therapeutic efficiency greatly towards resistant cancer cells by TRAIL nanovectorization. More importantly, when upon external laser, these nanocomposites not only triggered tumor photothermal therapy (PTT), but also upregulated the expression of death receptors (DR4 and DR5), resulting in a greater apoptosis mediated by co-delivered TRAIL ligand. Such photo/TRAIL synergistic effect showed its great killing effects in a controllable manner on TRAIL-resistant A549 tumor model bearing mice. Finally, these nanocomposites exhibited rapid clearance without obvious systemic toxicity. All these features rendered our nanocomposites a promising theranostic platform in cancer therapy. Copyright © 2018 Elsevier Ltd. All rights reserved.

  16. Sea level history in 3D: Data acquisition and processing for an ultra-high resolution MCS survey across IODP Expedition 313 drillsite

    NASA Astrophysics Data System (ADS)

    Nedimovic, M. R.; Mountain, G. S.; Austin, J. A., Jr.; Fulthorpe, C.; Aali, M.; Baldwin, K.; Bhatnagar, T.; Johnson, C.; Küçük, H. M.; Newton, A.; Stanley, J.

    2015-12-01

    In June-July 2015, we acquired the first 3D/2D hybrid (short/long streamer) multichannel seismic (MCS) reflection dataset. These data were collected simultaneously across IODP Exp. 313 drillsites, off New Jersey, using R/V Langsethand cover ~95% of the planned 12x50 km box. Despite the large survey area, the lateral and vertical resolution for the 3D dataset is almost a magnitude of order higher than for data gathered for standard petroleum exploration. Such high-resolution was made possible by collection of common midpoint (CMP) lines whose combined length is ~3 times the Earth's circumference (~120,000 profile km) and a source rich in high-frequencies. We present details on the data acquisition, ongoing data analysis, and preliminary results. The science driving this project is presented by Mountain et al. The 3D component of this innovative survey used an athwartship cross cable, extended laterally by 2 barovanes roughly 357.5 m apart and trailed by 24 50-m P-Cables spaced ~12.5 m with near-trace offset of 53 m. Each P-Cable had 8 single hydrophone groups spaced at 6.25 m for a total of 192 channels. Record length was 4 s and sample rate 0.5 ms, with no low cut and an 824 Hz high cut filter. We ran 77 sail lines spaced ~150 m. Receiver locations were determined using 2 GPS receivers mounted on floats and 2 compasses and depth sensors per streamer. Streamer depths varied from 2.1 to 3.7 m. The 2D component used a single 3 km streamer, with 240 9-hydrophone groups spaced at 12.5 m, towed astern with near-trace offset of 229 m. The record length was 4 s and sample rate 0.5 ms, with low cut filter at 2 Hz and high cut at 412 Hz. Receiver locations were recorded using GPS at the head float and tail buoy, combined with 12 bird compasses spaced ~300 m. Nominal streamer depth was 4.5 m. The source for both systems was a 700 in3 linear array of 4 Bolt air guns suspended at 4.5 m towing depth, 271.5 m behind the ship's stern. Shot spacing was 12.5 m. Data analysis to prestack time migration is being carried out by Absolute Imaging, a commercial company. The shipboard QC analysis and brute stacks indicate that the final product will be superb. Key advantages of the hybrid 3D/2D dataset are: (1) Velocity control from the 2D long-streamer data combined with the ultra-high resolution of the P-Cable 3D dataset; (2) Opportunity for prestack and poststack attribute analysis.

  17. 77 FR 25910 - National Trails System Act and Railroad Rights-of-Way

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-02

    ...] National Trails System Act and Railroad Rights-of-Way AGENCY: Surface Transportation Board, DOT. ACTION...) for rail banking and interim trail use under the National Trails System Act (Trails Act). New rules are adopted that require the parties jointly to notify the Board when an interim trail use/rail...

  18. Thigmotaxis Mediates Trail Odour Disruption.

    PubMed

    Stringer, Lloyd D; Corn, Joshua E; Sik Roh, Hyun; Jiménez-Pérez, Alfredo; Manning, Lee-Anne M; Harper, Aimee R; Suckling, David M

    2017-05-10

    Disruption of foraging using oversupply of ant trail pheromones is a novel pest management application under investigation. It presents an opportunity to investigate the interaction of sensory modalities by removal of one of the modes. Superficially similar to sex pheromone-based mating disruption in moths, ant trail pheromone disruption lacks an equivalent mechanistic understanding of how the ants respond to an oversupply of their trail pheromone. Since significant compromise of one sensory modality essential for trail following (chemotaxis) has been demonstrated, we hypothesised that other sensory modalities such as thigmotaxis could act to reduce the impact on olfactory disruption of foraging behaviour. To test this, we provided a physical stimulus of thread to aid trailing by Argentine ants otherwise under disruptive pheromone concentrations. Trail following success was higher using a physical cue. While trail integrity reduced under continuous over-supply of trail pheromone delivered directly on the thread, provision of a physical cue in the form of thread slightly improved trail following and mediated trail disruption from high concentrations upwind. Our results indicate that ants are able to use physical structures to reduce but not eliminate the effects of trail pheromone disruption.

  19. Prey-tracking behavior in the invasive terrestrial planarian Platydemus manokwari (Platyhelminthes, Tricladida)

    NASA Astrophysics Data System (ADS)

    Iwai, Noriko; Sugiura, Shinji; Chiba, Satoshi

    2010-11-01

    Platydemus manokwari is a broadly distributed invasive terrestrial flatworm that preys heavily on land snails and has been credited with the demise of numerous threatened island faunas. We examined whether P. manokwari tracks the mucus trails of land snail prey, investigated its ability to determine trail direction, and evaluated prey preference among various land snail species. A plastic treatment plate with the mucus trail of a single species and a control plate without the trail were placed side by side at the exit of cages housing P. manokwari. All trials were then videotaped overnight. The flatworms moved along plates with mucus trails, but did not respond to plates without trails, blank control (distilled water), or with conspecific flatworm trails. When presented at the midpoint of a snail mucus trail, the flatworms followed the trail in a random direction. The flatworms showed a preference when choosing between two plates, each with a mucus trail of different land snail species. Our results suggest that P. manokwari follows snail mucus trails based on chemical cues to increase the chance of encountering prey; however, trail-tracking behavior showed no directionality.

  20. Spatio-temporal propagation of cascading overload failures in spatially embedded networks

    NASA Astrophysics Data System (ADS)

    Zhao, Jichang; Li, Daqing; Sanhedrai, Hillel; Cohen, Reuven; Havlin, Shlomo

    2016-01-01

    Different from the direct contact in epidemics spread, overload failures propagate through hidden functional dependencies. Many studies focused on the critical conditions and catastrophic consequences of cascading failures. However, to understand the network vulnerability and mitigate the cascading overload failures, the knowledge of how the failures propagate in time and space is essential but still missing. Here we study the spatio-temporal propagation behaviour of cascading overload failures analytically and numerically on spatially embedded networks. The cascading overload failures are found to spread radially from the centre of the initial failure with an approximately constant velocity. The propagation velocity decreases with increasing tolerance, and can be well predicted by our theoretical framework with one single correction for all the tolerance values. This propagation velocity is found similar in various model networks and real network structures. Our findings may help to predict the dynamics of cascading overload failures in realistic systems.

  1. Spatio-temporal propagation of cascading overload failures in spatially embedded networks

    PubMed Central

    Zhao, Jichang; Li, Daqing; Sanhedrai, Hillel; Cohen, Reuven; Havlin, Shlomo

    2016-01-01

    Different from the direct contact in epidemics spread, overload failures propagate through hidden functional dependencies. Many studies focused on the critical conditions and catastrophic consequences of cascading failures. However, to understand the network vulnerability and mitigate the cascading overload failures, the knowledge of how the failures propagate in time and space is essential but still missing. Here we study the spatio-temporal propagation behaviour of cascading overload failures analytically and numerically on spatially embedded networks. The cascading overload failures are found to spread radially from the centre of the initial failure with an approximately constant velocity. The propagation velocity decreases with increasing tolerance, and can be well predicted by our theoretical framework with one single correction for all the tolerance values. This propagation velocity is found similar in various model networks and real network structures. Our findings may help to predict the dynamics of cascading overload failures in realistic systems. PMID:26754065

  2. The science of trail surveys: Recreation ecology provides new tools for managing wilderness trails

    USGS Publications Warehouse

    Marion, Jeffrey L.; Wimpey, Jeremy F.; Park, Logan O.

    2011-01-01

    Recreation ecology examines the effects of recreation on protected area ecosystems. One core focus of recreation ecology research is trail science, including the development of efficient protocols to assess and monitor the type and severity of resource impacts, analyses to improve knowledge of factors that influence trail conditions, and studies to assist land managers in improving trail design, maintenance, and visitor management. This article reviews alternative trail survey methodologies most useful for the management of wilderness and backcountry trail networks. Illustrations and implications from survey data for trail planning, design, and management are included.

  3. Cable equation for general geometry

    NASA Astrophysics Data System (ADS)

    López-Sánchez, Erick J.; Romero, Juan M.

    2017-02-01

    The cable equation describes the voltage in a straight cylindrical cable, and this model has been employed to model electrical potential in dendrites and axons. However, sometimes this equation might give incorrect predictions for some realistic geometries, in particular when the radius of the cable changes significantly. Cables with a nonconstant radius are important for some phenomena, for example, discrete swellings along the axons appear in neurodegenerative diseases such as Alzheimers, Parkinsons, human immunodeficiency virus associated dementia, and multiple sclerosis. In this paper, using the Frenet-Serret frame, we propose a generalized cable equation for a general cable geometry. This generalized equation depends on geometric quantities such as the curvature and torsion of the cable. We show that when the cable has a constant circular cross section, the first fundamental form of the cable can be simplified and the generalized cable equation depends on neither the curvature nor the torsion of the cable. Additionally, we find an exact solution for an ideal cable which has a particular variable circular cross section and zero curvature. For this case we show that when the cross section of the cable increases the voltage decreases. Inspired by this ideal case, we rewrite the generalized cable equation as a diffusion equation with a source term generated by the cable geometry. This source term depends on the cable cross-sectional area and its derivates. In addition, we study different cables with swelling and provide their numerical solutions. The numerical solutions show that when the cross section of the cable has abrupt changes, its voltage is smaller than the voltage in the cylindrical cable. Furthermore, these numerical solutions show that the voltage can be affected by geometrical inhomogeneities on the cable.

  4. Trail following and recruitment: Response of eastern tent caterpillarMalacosoma americanum to 5β-cholestane-3,24-dione and 5β-cholestan-3-one.

    PubMed

    Fitzgerald, T D

    1993-03-01

    Studies were conducted to determine the relative effectiveness of 5β-cholestane-3,24-dione (diketone) and 5β-cholestan-3-one (monoketone) in eliciting trail following from eastern tent caterpillars,Malacosoma americanum. In Y maze tests, trails prepared from the monoketone were followed preferentially over diketone trails, even when the diketone trail was several orders of magnitude stronger. Under field conditions, colonies readily abandoned well-developed trail systems in favor of artificial trails that were established with the monoketone. Other tests in which the caterpillars selected trails prepared from the monoketone (but not the diketone) more often than their own recruitment trails indicate that the monoketone constitutes the chemical basis of recruitment communication in this insect. The study also shows that tent caterpillars are highly sensitive to small differences in the amount of monoketone in a trail and can distinguish between new and aged trails prepared from the compound.

  5. Chemical trail marking and following by caterpillars ofMalacosoma neustria.

    PubMed

    Peterson, S C

    1988-03-01

    Chemical trail marking and following by gregarious caterpillars,Malacosoma neustria L. (Lepidoptera: Lasiocampidae), was studied in the laboratory. As in other species ofMalacosoma, larvae deposit a trail pheromone from a sternal secretory site when searching the host for food. Larvae in the vanguard of foraging columns establish chemical trails as they explore new territory. Marking behavior diminishes as successive unfed foragers utilize the trail. These exploratory trails are subsequently overmarked by fed larvae returning to the tent. Other foragers follow the trails of fed larvae in preference to trails of unfed larvae. Thus, like the eastern tent caterpillar,M. americanum, successful foragers ofM. neustria recruit colony-mates to feeding sites. The chemical activity of both recruitment and exploratory trails degrades slowly, suggesting that the trail pheromone ofM. neustria is a nonvolatile substance. Caterpillars ofM. neustria readily follow the nonvolatile trail pheromone which has been identified fromM. americanum, 5β-cholestane-3,24-dione.

  6. Accurate Natural Trail Detection Using a Combination of a Deep Neural Network and Dynamic Programming.

    PubMed

    Adhikari, Shyam Prasad; Yang, Changju; Slot, Krzysztof; Kim, Hyongsuk

    2018-01-10

    This paper presents a vision sensor-based solution to the challenging problem of detecting and following trails in highly unstructured natural environments like forests, rural areas and mountains, using a combination of a deep neural network and dynamic programming. The deep neural network (DNN) concept has recently emerged as a very effective tool for processing vision sensor signals. A patch-based DNN is trained with supervised data to classify fixed-size image patches into "trail" and "non-trail" categories, and reshaped to a fully convolutional architecture to produce trail segmentation map for arbitrary-sized input images. As trail and non-trail patches do not exhibit clearly defined shapes or forms, the patch-based classifier is prone to misclassification, and produces sub-optimal trail segmentation maps. Dynamic programming is introduced to find an optimal trail on the sub-optimal DNN output map. Experimental results showing accurate trail detection for real-world trail datasets captured with a head mounted vision system are presented.

  7. I just want to be left alone: Daily overload and marital behavior.

    PubMed

    Sears, Meredith S; Repetti, Rena L; Robles, Theodore F; Reynolds, Bridget M

    2016-08-01

    Stressful, busy days have been linked with increases in angry and withdrawn marital behavior. The process by which stressors in 1 domain, such as work, affect an individual’s behavior in another domain, such as the marital relationship, is known as spillover . Using 56 days of daily diary reports in a diverse sample of 47 wives and 39 husbands, this study examined associations between daily experiences of overload and 3 marital behaviors: overt expressions of anger, disregard of the spouse’s needs (“disregard”), and reductions in affection and disclosure (“distancing”). Two potential mechanisms by which daily overload spills over into marital behavior were examined: negative mood and the desire to avoid social interaction. Among husbands, negative mood mediated the association between overload and angry behavior. Associations between overload and wives’ angry behavior, as well as overload and husbands’ and wives’ disregard of their partners’ needs, were mediated by both negative mood and the desire to withdraw socially. Desire to withdraw, but not negative mood, mediated the association between overload and distancing behavior among husbands and wives. In addition, associations between marital satisfaction and spouses’ typical marital behavior, as well as behavioral responses to overload, were examined. Husbands’ and wives’ average levels of expressed anger and disregard, and husbands’ distancing, were associated with lower marital satisfaction in 1 or both partners. Both spouses reported lower marital satisfaction if husbands tended to express marital anger, disregard, or distancing on busy, overloaded days. PsycINFO Database Record (c) 2016 APA, all rights reserved

  8. Iron overload prevents oxidative damage to rat brain after chlorpromazine administration.

    PubMed

    Piloni, Natacha E; Caro, Andres A; Puntarulo, Susana

    2018-05-15

    The hypothesis tested is that Fe administration leads to a response in rat brain modulating the effects of later oxidative challenges such as chlorpromazine (CPZ) administration. Either a single dose (acute Fe overload) or 6 doses every second day (sub-chronic Fe overload) of 500 or 50 mg Fe-dextran/kg, respectively, were injected intraperitoneally (ip) to rats. A single dose of 10 mg CPZ/kg was injected ip 8 h after Fe treatment. DNA integrity was evaluated by quantitative PCR, lipid radical (LR · ) generation rate by electron paramagnetic resonance (EPR), and catalase (CAT) activity by UV spectrophotometry in isolated brains. The maximum increase in total Fe brain was detected after 6 or 2 h in the acute and sub-chronic Fe overload model, respectively. Mitochondrial and nuclear DNA integrity decreased after acute Fe overload at the time of maximal Fe content; the decrease in DNA integrity was lower after sub-chronic than after acute Fe overload. CPZ administration increased LR · generation rate in control rat brain after 1 and 2 h; however, CPZ administration after acute or sub-chronic Fe overload did not affect LR · generation rate. CPZ treatment did not affect CAT activity after 1-4 h neither in control rats nor in acute Fe-overloaded rats. However, CPZ administration to rats treated sub-chronically with Fe showed increased brain CAT activity after 2 or 4 h, as compared to control values. Fe supplementation prevented brain damage in both acute and sub-chronic models of Fe overload by selectively activating antioxidant pathways.

  9. Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia

    PubMed Central

    Anderson, Erik R.; Taylor, Matthew; Xue, Xiang; Ramakrishnan, Sadeesh K.; Martin, Angelical; Xie, Liwei; Bredell, Bryce X.; Gardenghi, Sara; Rivella, Stefano; Shah, Yatrik M.

    2013-01-01

    Several distinct congenital disorders can lead to tissue-iron overload with anemia. Repeated blood transfusions are one of the major causes of iron overload in several of these disorders, including β-thalassemia major, which is characterized by a defective β-globin gene. In this state, hyperabsorption of iron is also observed and can significantly contribute to iron overload. In β-thalassemia intermedia, which does not require blood transfusion for survival, hyperabsorption of iron is the leading cause of iron overload. The mechanism of increased iron absorption in β-thalassemia is unclear. We definitively demonstrate, using genetic mouse models, that intestinal hypoxia-inducible factor-2α (HIF2α) and divalent metal transporter-1 (DMT1) are activated early in the pathogenesis of β-thalassemia and are essential for excess iron accumulation in mouse models of β-thalassemia. Moreover, thalassemic mice with established iron overload had significant improvement in tissue-iron levels and anemia following disruption of intestinal HIF2α. In addition to repeated blood transfusions and increased iron absorption, chronic hemolysis is the major cause of tissue-iron accumulation in anemic iron-overload disorders caused by hemolytic anemia. Mechanistic studies in a hemolytic anemia mouse model demonstrated that loss of intestinal HIF2α/DMT1 signaling led to decreased tissue-iron accumulation in the liver without worsening the anemia. These data demonstrate that dysregulation of intestinal hypoxia and HIF2α signaling is critical for progressive iron overload in β-thalassemia and may be a novel therapeutic target in several anemic iron-overload disorders. PMID:24282296

  10. Trails research: where do we go from here?

    Treesearch

    Michael A. Schuett; Patricia Seiser

    2002-01-01

    This paper describes a recent study focusing on trails research needs. This study was supported by American Trails. Using a Delphi technique, 86 trails experts representing a variety of federal, state and local agencies, nonprofits, and trail uses were queried by email on trails research needs. A Delphi technique is a prognostic tool for dealing with complex problems...

  11. Ecological criteria, participant preferences and location models: A GIS approach toward ATV trail planning

    Treesearch

    Stephanie A. Snyder; Jay H. Whitmore; Ingrid E. Schneider; Dennis R. Becker

    2008-01-01

    This paper presents a geographic information system (GIS)-based method for recreational trail location for all-terrain vehicles (ATVs) which considers environmental factors, as well as rider preferences for trail attributes. The method utilizes the Least-Cost Path algorithm within a GIS framework to optimize trail location. The trail location algorithm considered trail...

  12. Bridge Analysis and Evaluation of Effects Under Overload Vehicles

    DOT National Transportation Integrated Search

    2009-12-01

    Movement of industrial freight infrequently requires special overload vehicles weighing 5 to 6 times the normal legal truck weight to move across highway systems. The gross vehicle weight of the overload vehicles frequently exceeds 400 kips while the...

  13. Fuse protects circuit from voltage and current overloads

    NASA Technical Reports Server (NTRS)

    Casey, L. O.

    1969-01-01

    Low-melting resistor connected in series with the load protects the circuit against current overloads. It protects test subjects and patients being monitored by electronic instrumentation from inadvertant overloads of current, and sensitive electronic equipment against high-voltage damage.

  14. Estimating soil erosion on hiking trails in the Sierra Mariola Natural Park in southern Spain

    NASA Astrophysics Data System (ADS)

    Magdalena Warter, Maria; Peeters, Mattias; Kuppen, Emiel; Blok, Kas; Dilly, Lina

    2017-04-01

    Natural parks and protected natural areas provide excellent recreational opportunities for outdoor activities through the richness of the natural environment and the abundance of walking trails. Hiking, mountain biking and running have rapidly gained popularity over recent years increasing concerns about the erosion and degradation of hiking trails caused by (over)use. This is also the case in the Sierra Mariola Natural Park in southeast Spain, which is a popular destination for tourists due to its diverse fauna and flora. The increasing number of tourists together with the negative impacts of climate change necessitates a better understanding of the key soil erosion processes impacting hiking trails. There are 4 scenic trail routes in the Natural Park amounting to 21 km plus an additional network of unofficial trails. Apart from the heavy touristic traffic on the trails there are large trail running events with up to 1000 participants becoming increasingly popular, however local park authorities have voiced concerns about the impacts of these activities on the trails. Despite the popularity of walking trails around the world, there is a paucity of research exploring soil erosion from these features. Therefore, the aims of this study are: 1) to ascertain the amount of erosion that occurs on trails in the Sierra Mariola Natural Park, and 2) determine the key factors that influence soil erosion. Some 100 km of trails were evaluated (both official and unmarked trails), with route segments ranging between 2 and 10 km. A trail classification system was developed to group trail segments based on their surface characteristics (bedrock, gravel, mixed sediment, soil or man-made) and specific erosion features (rills, ditch-shaped, tilted). For each class, the average erosion rate was calculated which ranged from 262 t/ha for soil-based trails to 2006 t/ha for heavily eroded, ditch-shaped trails. The spatial distribution of the different erosion rates and trail types were mapped using ArcGIS to provide an overview of the most affected areas. A DEM model of the park was also used to assess the relative influence on erosion of various factors such as slope, geology, aspect and elevation. Slope, aspect, vegetation and geology are the key variables influencing the erosion rate of trails. Also, the amount and type of trail use also influence trail erosion. Further studies are recommended to explore the carrying capacity and threshold limits of trails.

  15. Irigenin sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells.

    PubMed

    Xu, Ying; Gao, Cheng-Cheng; Pan, Zhen-Guo; Zhou, Chuan-Wen

    2018-02-12

    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) holds promising value for cancer therapy due to its capacity to induce apoptosis in cancer cells. Nevertheless, TRAIL therapy is greatly hampered by its resistance. Irigenin (Iri), isoflavonoids, can be isolated from the rhizome of Belamcanda chinensis, and has been shown anti-cancer properties. In this study, we explored if Iri could enhance TRAIL-regulated apoptosis in TRAIL resistant gastric cancer cells. Iri significantly potentiated TRAIL-triggered cytotoxicity. Iri alone and TRAIL alone showed no effective role in apoptosis induction, whereas combined treatment with Iri and TRAIL markedly induced apoptosis in cancer cells, as evidenced by the up-regulation of cleaved Caspase-8/-9/-3 and PARP. Additionally, the sensitization to TRAIL was along with the enhancement of pro-apoptotic proteins, including FAS-associated protein with death domain (FADD), death receptor 5 (DR5) and Bax. And suppressing FADD, DR5 and Bax by si RNA significantly reduced the apoptosis and enhanced the cell viability induced by the co-application of Iri and TRAIL. Moreover, the sensitization to TRAIL was accompanied by the decrease of Cellular-FLICE inhibitory protein (c-FLIP), Bcl-2 and Survivin. Additionally, Iri could sensitize TRAIL to produce reactive oxygen species (ROS). Pre-treatment of N-acetyl-cysteine (NAC), ROS scavenger, attenuated Iri plus TRAIL-induced apoptosis and improved cell viability. Finally, combination of Iri and TRAIL inhibited tumor growth in the xenograft model. Collectively, our present study gave new insights into the effects of Iri on potentiating TRAIL-sensitivity, and suggested that Iri could be a potential candidate for sensitizer of TRAIL-resistant cancer cell treatment. Copyright © 2018. Published by Elsevier Inc.

  16. Modelling and measurement of crack closure and crack growth following overloads and underloads

    NASA Technical Reports Server (NTRS)

    Dexter, R. J.; Hudak, S. J.; Davidson, D. L.

    1989-01-01

    Ignoring crack growth retardation following overloads can result in overly conservative life predictions in structures subjected to variable amplitude fatigue loading. Crack closure is believed to contribute to the crack growth retardation, although the specific closure mechanism is dabatable. The delay period and corresponding crack growth rate transients following overload and overload/underload cycles were systematically measured as a function of load ratio and overload magnitude. These responses are correlated in terms of the local 'driving force' for crack growth, i.e. the effective stress intensity factor range. Experimental results are compared with the predictions of a Dugdale-type (1960) crack closure model, and improvements in the model are suggested.

  17. Overload protection system for power inverter

    NASA Technical Reports Server (NTRS)

    Nagano, S. (Inventor)

    1977-01-01

    An overload protection system for a power inverter utilized a first circuit for monitoring current to the load from the power inverter to detect an overload and a control circuit to shut off the power inverter, when an overload condition was detected. At the same time, a monitoring current inverter was turned on to deliver current to the load at a very low power level. A second circuit monitored current to the load, from the monitoring current inverter, to hold the power inverter off through the control circuit, until the overload condition was cleared so that the control circuit may be deactivated in order for the power inverter to be restored after the monitoring current inverter is turned off completely.

  18. Awareness and use of community walking trails.

    PubMed

    Reed, Julian A; Ainsworth, Barbara E; Wilson, Dawn K; Mixon, Gary; Cook, Annette

    2004-11-01

    Community trail development is an emerging strategy to increase physical activity (PA) among community residents. The purpose of this study was to assess awareness and use of trails and compare perceptions to objective data. A telephone survey was administered to a stratified sample of adults (N = 1,112) in a southeastern county in the United States. Respondents' home addresses and the locations of trails were entered into a GIS database. A kappa statistic was used to measure agreement between awareness and presence of trails. Differences in reported trail use patterns by sex, race, education, and PA levels were evaluated. There was no agreement between the awareness and presence of trails (kappa = 0.07). Fifty-six percent of the respondents reported having trails; however, only 33% reported using the trails. Of the trail users, 42% reported being regularly active in moderate-to-vigorous PA (30+ min/day for 5+ days/week), and 51% reported being less active (P < 0.003). Among walkers (> or =30 min/day for > or =5 days/week), 49% of regular walkers and 35% of irregular walkers (< walkers) reported using the trails (P < 0.04). Awareness of existing trails in this community and levels of use were low. Marketing programs should promote awareness and use of trails among older adults and irregularly active adults.

  19. The association of trail use with weather-related factors on an urban greenway.

    PubMed

    Burchfield, Ryan A; Fitzhugh, Eugene C; Bassett, David R

    2012-02-01

    To study the association between weather-related measures and objectively measured trail use across 3 seasons. Weather has been reported as a barrier to outdoor physical activity (PA), but previous studies have explained only a small amount of the variance in PA using weather-related measures. The dependent variable of this study was trail use measured as mean hourly trail counts by an infrared trail counter located on a greenway. Each trail count represents 1 person breaking the infrared beam of the trail counter. Two sources of weather-related measures were obtained by a site-specific weather station and a public domain weather source. Temperature, relative humidity, and precipitation were significantly correlated with trail counts recorded during daylight hours. More precise hourly weather-related measures explained 42% of the variance in trail counts, regardless of the weather data source with temperature alone explaining 18% of the variance in trail counts. After controlling for all seasonal and weekly factors, every 1°F increase in temperature was associated with an increase of 1.1 trail counts/hr up to 76°F, at which point trail use began to slightly decrease. Weather-related factors have a moderate association with trail use along an urban greenway.

  20. A spatial exploration of informal trail networks within Great Falls Park, VA

    USGS Publications Warehouse

    Wimpey, Jeremy; Marion, Jeffrey L.

    2011-01-01

    Informal (visitor-created) trails represent a threat to the natural resources of protected natural areas around the globe. These trails can remove vegetation, displace wildlife, alter hydrology, alter habitat, spread invasive species, and fragment landscapes. This study examines informal and formal trails within Great Falls Park, VA, a sub-unit of the George Washington Memorial Parkway, managed by the U.S. National Park Service. This study sought to answer three specific questions: 1) Are the physical characteristics and topographic alignments of informal trails significantly different from formal trails, 2) Can landscape fragmentation metrics be used to summarize the relative impacts of formal and informal trail networks on a protected natural area? and 3) What can we learn from examining the spatial distribution of the informal trails within protected natural areas? Statistical comparisons between formal and informal trails in this park indicate that informal trails have less sustainable topographic alignments than their formal counterparts. Spatial summaries of the lineal and areal extent and fragmentation associated with the trail networks by park management zones compare park management goals to the assessed attributes. Hot spot analyses highlight areas of high trail density within the park and findings provide insights regarding potential causes for development of dense informal trail networks.

  1. Certification trails for data structures

    NASA Technical Reports Server (NTRS)

    Sullivan, Gregory F.; Masson, Gerald M.

    1993-01-01

    Certification trails are a recently introduced and promising approach to fault detection and fault tolerance. The applicability of the certification trail technique is significantly generalized. Previously, certification trails had to be customized to each algorithm application; trails appropriate to wide classes of algorithms were developed. These certification trails are based on common data-structure operations such as those carried out using these sets of operations such as those carried out using balanced binary trees and heaps. Any algorithms using these sets of operations can therefore employ the certification trail method to achieve software fault tolerance. To exemplify the scope of the generalization of the certification trail technique provided, constructions of trails for abstract data types such as priority queues and union-find structures are given. These trails are applicable to any data-structure implementation of the abstract data type. It is also shown that these ideals lead naturally to monitors for data-structure operations.

  2. Happy trails: the effect of a media campaign on urban trail use in southern Nevada.

    PubMed

    Clark, Sheila; Bungum, Tim J; Meacham, Mindy; Coker, Lisa

    2015-01-01

    Many Americans do not meet recommendations for physical activity (PA). Communities are building trail networks to encourage PA, but the relationship between trails and PA is not well understood. We monitored usage of urban trails (N = 10) in Las Vegas, NV, before and after a promotional marketing campaign (October 2011 and April 2012). The media campaign featured print, online, and radio ads, as well as billboards and signage on gas pumps. Data were collected with infrared monitors that were placed on the trails for periods of 7 days. We compared preintervention and postintervention usage rates. Mean usage increased (P < .001) from 3.91 to 5.95 users per hour (52.17%) after the promotional campaign. We observed significant increases at 7 individual trails, significant declines at 2 trails, and no change at 1 trail. Promotional campaigns may be an effective way to increase trail usage and encourage PA.

  3. Trail-following in termites: Evidence for a multicomponent system.

    PubMed

    Kaib, M; Bruinsma, O; Leuthold, R H

    1982-09-01

    Several African termite species from different subfamilies and different habitats are sensitive to trail-active extracts or to naturally laid trails from other species. Using single-extract bioassays, it is shown that the response threshold for trail-following is nearly identical for all tested species (except forHodotermes mossambicus). However, when termite workers have a choice between trails from their own species and from other species, conspecific trail-following is exclusively observed. This phenomenon can be counteracted by dilution (1∶10) of the conspecific trail-pheromone extract. Tests of the trail activity of various synthetic alcohols show that among these, the highest sensitivity of termite workers is to (Z)-3-dodecen-1-ol. Based on our experimental data, we postulate that, in addition to a generally active trail-pheromone constituent (an unsaturated primary C12 alcohol) or a pool of chemically closely related alcohols, other species-specific components are present in termite trails.

  4. Implementing Filters to Identify and Prioritize Industrial Base Risk: Rules of Thumb to Reduce Cognitive Overload

    DTIC Science & Technology

    2015-04-30

    Thumb to Reduce Cognitive Overload Sally Sleeper, ODASD[M&IBP] John F. Starns, Northrop Grumman Published April 30, 2015 Disclaimer: The views...Prioritize Industrial Base Risk: Rules of Thumb to Reduce Cognitive Overload 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6... Cognitive Overload Sally Sleeper—joined the Office of the Deputy Assistant Secretary of Defense for Manufacturing and Industrial Base Policy as Senior

  5. Association of iron overload with allogeneic hematopoietic cell transplantation outcomes: a prospective cohort study using R2-MRI–measured liver iron content

    PubMed Central

    Trottier, Bryan J.; Burns, Linda J.; DeFor, Todd E.; Cooley, Sarah

    2013-01-01

    Using liver magnetic resonance imaging (R2-MRI) to quantify liver iron content (LIC), we conducted a prospective cohort study to determine the association between iron overload and adult allogeneic hematopoietic cell transplantation (HCT) outcomes. Patients received pretransplant ferritin measurements; patients with ferritin >500 ng/mL underwent R2-MRI. Patients were defined as no iron overload (N = 28) and iron overload (LIC >1.8 mg/g; N = 60). Median LIC in the iron-overload group was 4.3 mg/g (range, 1.9-25.4). There was no difference in the 1-year probability of overall survival, nonrelapse mortality, relapse, acute or chronic graft-versus-host disease, organ failure, infections, or hepatic veno-occlusive disease between groups. We also found no difference in the cumulative incidence of a composite end point of nonrelapse mortality, any infection, organ failure, or hepatic veno-occlusive disease (1-year cumulative incidence, 71% vs 80%; P = .44). In multivariate analyses, iron-overload status did not impact risks of overall mortality (relative risk = 2.3; 95% confidence interval, 0.9-5.9; P = .08). In conclusion, we found no association between pretransplant iron overload and allogeneic HCT outcomes. Future studies in this population should use LIC to define iron overload instead of ferritin. PMID:23777771

  6. Cable and Line Inspection Mechanism

    NASA Technical Reports Server (NTRS)

    Ross, Terence J. (Inventor)

    2003-01-01

    An automated cable and line inspection mechanism visually scans the entire surface of a cable as the mechanism travels along the cable=s length. The mechanism includes a drive system, a video camera, a mirror assembly for providing the camera with a 360 degree view of the cable, and a laser micrometer for measuring the cable=s diameter. The drive system includes an electric motor and a plurality of drive wheels and tension wheels for engaging the cable or line to be inspected, and driving the mechanism along the cable. The mirror assembly includes mirrors that are positioned to project multiple images of the cable on the camera lens, each of which is of a different portion of the cable. A data transceiver and a video transmitter are preferably employed for transmission of video images, data and commands between the mechanism and a remote control station.

  7. Cable and line inspection mechanism

    NASA Technical Reports Server (NTRS)

    Ross, Terence J. (Inventor)

    2003-01-01

    An automated cable and line inspection mechanism visually scans the entire surface of a cable as the mechanism travels along the cable=s length. The mechanism includes a drive system, a video camera, a mirror assembly for providing the camera with a 360 degree view of the cable, and a laser micrometer for measuring the cable=s diameter. The drive system includes an electric motor and a plurality of drive wheels and tension wheels for engaging the cable or line to be inspected, and driving the mechanism along the cable. The mirror assembly includes mirrors that are positioned to project multiple images of the cable on the camera lens, each of which is of a different portion of the cable. A data transceiver and a video transmitter are preferably employed for transmission of video images, data and commands between the mechanism and a remote control station.

  8. Indicators and protocols for monitoring impacts of formal and informal trails in protected areas

    USGS Publications Warehouse

    Marion, Jeffrey L.; Leung, Yu-Fai

    2011-01-01

    Trails are a common recreation infrastructure in protected areas and their conditions affect the quality of natural resources and visitor experiences. Various trail impact indicators and assessment protocols have been developed in support of monitoring programs, which are often used for management decision-making or as part of visitor capacity management frameworks. This paper reviews common indicators and assessment protocols for three types of trails, surfaced formal trails, unsurfaced formal trails, and informal (visitor-created) trails. Monitoring methods and selected data from three U.S. National Park Service units are presented to illustrate some common trail impact indicators and assessment options.

  9. Mechanisms of Cables 1 gene inactivation in human ovarian cancer development.

    PubMed

    Sakamoto, Hideo; Friel, Anne M; Wood, Antony W; Guo, Lankai; Ilic, Ana; Seiden, Michael V; Chung, Daniel C; Lynch, Maureen P; Serikawa, Takehiro; Munro, Elizabeth; Oliva, Esther; Orsulic, Sandra; Kirley, Sandra D; Foster, Rosemary; Zukerberg, Lawrence R; Rueda, Bo R

    2008-02-01

    Cables 1, a cyclin-dependent kinase binding protein, is primarily involved in cell cycle regulation. Loss of nuclear Cables 1 expression is observed in human colon, lung and endometrial cancers. We previously reported that loss of nuclear Cables 1 expression was also observed with high frequency in a limited sample set of human ovarian carcinomas, although the mechanisms underlying loss of nuclear Cables 1 expression remained unknown. Our present objective was to examine Cables 1 expression in ovarian cancer in greater detail, and determine the predominant mechanisms of Cables 1 loss. We assessed potential genetic and epigenetic modifications of the Cables 1 locus through analyses of mutation, polymorphisms, loss of heterozygosity and DNA methylation. We observed a marked loss of nuclear Cables 1 expression in serous and endometrioid ovarian carcinomas that correlated with decreased Cables 1 mRNA levels. Although we detected no Cables 1 mutations, there was evidence of LOH at the Cables 1 locus and epigenetic modification of the Cables 1 promoter region in a subset of ovarian carcinomas and established cancer cell lines. From a functional perspective, over-expression of Cables 1 induced apoptosis, whereas, knockdown of Cables 1 negated this effect. Together these findings suggest that multiple mechanisms underlie the loss of Cables 1 expression in ovarian cancer cells, supporting the hypothesis that Cables 1 is a tumor suppressor in human ovarian cancer.

  10. Development of inspection robots for bridge cables.

    PubMed

    Yun, Hae-Bum; Kim, Se-Hoon; Wu, Liuliu; Lee, Jong-Jae

    2013-01-01

    This paper presents the bridge cable inspection robot developed in Korea. Two types of the cable inspection robots were developed for cable-suspension bridges and cable-stayed bridge. The design of the robot system and performance of the NDT techniques associated with the cable inspection robot are discussed. A review on recent advances in emerging robot-based inspection technologies for bridge cables and current bridge cable inspection methods is also presented.

  11. Fluid overload and changes in serum creatinine after cardiac surgery: predictors of mortality and longer intensive care stay. A prospective cohort study

    PubMed Central

    2012-01-01

    Introduction Fluid overload is a clinical problem frequently related to cardiac and renal dysfunction. The aim of this study was to evaluate fluid overload and changes in serum creatinine as predictors of cardiovascular mortality and morbidity after cardiac surgery. Methods Patients submitted to heart surgery were prospectively enrolled in this study from September 2010 through August 2011. Clinical and laboratory data were collected from each patient at preoperative and trans-operative moments and fluid overload and creatinine levels were recorded daily after cardiac surgery during their ICU stay. Fluid overload was calculated according to the following formula: (Sum of daily fluid received (L) - total amount of fluid eliminated (L)/preoperative weight (kg) × 100). Preoperative demographic and risk indicators, intra-operative parameters and postoperative information were obtained from medical records. Patients were monitored from surgery until death or discharge from the ICU. We also evaluated the survival status at discharge from the ICU and the length of ICU stay (days) of each patient. Results A total of 502 patients were enrolled in this study. Both fluid overload and changes in serum creatinine correlated with mortality (odds ratio (OR) 1.59; confidence interval (CI): 95% 1.18 to 2.14, P = 0.002 and OR 2.91; CI: 95% 1.92 to 4.40, P <0.001, respectively). Fluid overload played a more important role in the length of intensive care stay than changes in serum creatinine. Fluid overload (%): b coefficient = 0.17; beta coefficient = 0.55, P <0.001); change in creatinine (mg/dL): b coefficient = 0.01; beta coefficient = 0.11, P = 0.003). Conclusions Although both fluid overload and changes in serum creatinine are prognostic markers after cardiac surgery, it seems that progressive fluid overload may be an earlier and more sensitive marker of renal dysfunction affecting heart function and, as such, it would allow earlier intervention and more effective control in post cardiac surgery patients. PMID:22651844

  12. Heat shock transcription factor 1-deficiency attenuates overloading-associated hypertrophy of mouse soleus muscle.

    PubMed

    Koya, Tomoyuki; Nishizawa, Sono; Ohno, Yoshitaka; Goto, Ayumi; Ikuta, Akihiro; Suzuki, Miho; Ohira, Tomotaka; Egawa, Tatsuro; Nakai, Akira; Sugiura, Takao; Ohira, Yoshinobu; Yoshioka, Toshitada; Beppu, Moroe; Goto, Katsumasa

    2013-01-01

    Hypertrophic stimuli, such as mechanical stress and overloading, induce stress response, which is mediated by heat shock transcription factor 1 (HSF1), and up-regulate heat shock proteins (HSPs) in mammalian skeletal muscles. Therefore, HSF1-associated stress response may play a key role in loading-associated skeletal muscle hypertrophy. The purpose of this study was to investigate the effects of HSF1-deficiency on skeletal muscle hypertrophy caused by overloading. Functional overloading on the left soleus was performed by cutting the distal tendons of gastrocnemius and plantaris muscles for 4 weeks. The right muscle served as the control. Soleus muscles from both hindlimbs were dissected 2 and 4 weeks after the operation. Hypertrophy of soleus muscle in HSF1-null mice was partially inhibited, compared with that in wild-type (C57BL/6J) mice. Absence of HSF1 partially attenuated the increase of muscle wet weight and fiber cross-sectional area of overloaded soleus muscle. Population of Pax7-positive muscle satellite cells in HSF1-null mice was significantly less than that in wild-type mice following 2 weeks of overloading (p<0.05). Significant up-regulations of interleukin (IL)-1β and tumor necrosis factor mRNAs were observed in HSF1-null, but not in wild-type, mice following 2 weeks of overloading. Overloading-related increases of IL-6 and AFT3 mRNA expressions seen after 2 weeks of overloading tended to decrease after 4 weeks in both types of mice. In HSF1-null mice, however, the significant overloading-related increase in the expression of IL-6, not ATF3, mRNA was noted even at 4th week. Inhibition of muscle hypertrophy might be attributed to the greater and prolonged enhancement of IL-6 expression. HSF1 and/or HSF1-mediated stress response may, in part, play a key role in loading-induced skeletal muscle hypertrophy.

  13. Heat Shock Transcription Factor 1-Deficiency Attenuates Overloading-Associated Hypertrophy of Mouse Soleus Muscle

    PubMed Central

    Koya, Tomoyuki; Nishizawa, Sono; Ohno, Yoshitaka; Goto, Ayumi; Ikuta, Akihiro; Suzuki, Miho; Ohira, Tomotaka; Egawa, Tatsuro; Nakai, Akira; Sugiura, Takao; Ohira, Yoshinobu; Yoshioka, Toshitada; Beppu, Moroe; Goto, Katsumasa

    2013-01-01

    Hypertrophic stimuli, such as mechanical stress and overloading, induce stress response, which is mediated by heat shock transcription factor 1 (HSF1), and up-regulate heat shock proteins (HSPs) in mammalian skeletal muscles. Therefore, HSF1-associated stress response may play a key role in loading-associated skeletal muscle hypertrophy. The purpose of this study was to investigate the effects of HSF1-deficiency on skeletal muscle hypertrophy caused by overloading. Functional overloading on the left soleus was performed by cutting the distal tendons of gastrocnemius and plantaris muscles for 4 weeks. The right muscle served as the control. Soleus muscles from both hindlimbs were dissected 2 and 4 weeks after the operation. Hypertrophy of soleus muscle in HSF1-null mice was partially inhibited, compared with that in wild-type (C57BL/6J) mice. Absence of HSF1 partially attenuated the increase of muscle wet weight and fiber cross-sectional area of overloaded soleus muscle. Population of Pax7-positive muscle satellite cells in HSF1-null mice was significantly less than that in wild-type mice following 2 weeks of overloading (p<0.05). Significant up-regulations of interleukin (IL)-1β and tumor necrosis factor mRNAs were observed in HSF1-null, but not in wild-type, mice following 2 weeks of overloading. Overloading-related increases of IL-6 and AFT3 mRNA expressions seen after 2 weeks of overloading tended to decrease after 4 weeks in both types of mice. In HSF1-null mice, however, the significant overloading-related increase in the expression of IL-6, not ATF3, mRNA was noted even at 4th week. Inhibition of muscle hypertrophy might be attributed to the greater and prolonged enhancement of IL-6 expression. HSF1 and/or HSF1-mediated stress response may, in part, play a key role in loading-induced skeletal muscle hypertrophy. PMID:24167582

  14. Increased risk of volume overload with plasma compared with four‐factor prothrombin complex concentrate for urgent vitamin K antagonist reversal

    PubMed Central

    Refaai, Majed A.; Goldstein, Joshua N.; Lee, Martin L.; Durn, Billie L.; Milling, Truman J.; Sarode, Ravi

    2015-01-01

    BACKGROUND Plasma is commonly used for vitamin K antagonist (VKA) reversal, but observational studies suggest that it is associated with transfusion‐related adverse reactions (e.g., volume overload). However, this issue has not previously been addressed in a randomized controlled trial (RCT). STUDY DESIGN AND METHODS Factors associated with volume overload were examined using data from two Phase IIIb RCTs comparing plasma with four‐factor prothrombin complex concentrate (4F‐PCC, Beriplex/Kcentra, CSL Behring) for urgent VKA reversal. VKA‐treated patients with major bleeding (NCT00708435) or requiring an urgent surgical or invasive procedure (NCT00803101) were randomly assigned (1:1) to receive either plasma or 4F‐PCC, concomitant with vitamin K. Adverse events (AEs) and serious AEs were prospectively captured up to Day 10 and 45, respectively. Volume overload predictors were evaluated on a univariate and multivariate basis. RESULTS A total of 388 patients (4F‐PCC, n = 191; plasma, n = 197) were enrolled. Volume overload occurred in 34 (9%) patients (4F‐PCC, n = 9; plasma, n = 25). In univariate analyses, use of plasma (vs. 4F‐PCC), use of nonstudy plasma and/or platelets, race, history of congestive heart failure (CHF), and history of renal disease were associated with volume overload. In multivariate analyses, use of plasma (vs. 4F‐PCC), history of CHF, and history of renal disease were independent volume overload predictors. In an additional analysis restricted to volume overload events recorded up to Day 7, only use of plasma (vs. 4F‐PCC) was an independent volume overload predictor. CONCLUSIONS After adjusting for other potential risk factors, plasma use was independently associated with a greater risk of volume overload than 4F‐PCC in patients requiring urgent VKA reversal. PMID:26135740

  15. Metformin sensitizes triple-negative breast cancer to proapoptotic TRAIL receptor agonists by suppressing XIAP expression.

    PubMed

    Strekalova, Elena; Malin, Dmitry; Rajanala, Harisha; Cryns, Vincent L

    2017-06-01

    Despite robust antitumor activity in diverse preclinical models, TNF-related apoptosis-inducing ligand (TRAIL) receptor agonists have not demonstrated efficacy in clinical trials, underscoring the need to identify agents that enhance their activity. We postulated that the metabolic stress induced by the diabetes drug metformin would sensitize breast cancer cells to TRAIL receptor agonists. Human triple (estrogen receptor, progesterone receptor, and HER2)-negative breast cancer (TNBC) cell lines were treated with TRAIL receptor agonists (monoclonal antibodies or TRAIL peptide), metformin, or the combination. The effects on cell survival, caspase activation, and expression of TRAIL receptors and the antiapoptotic protein XIAP were determined. In addition, XIAP was silenced by RNAi in TNBC cells and the effects on sensitivity to TRAIL were determined. The antitumor effects of metformin, TRAIL, or the combination were evaluated in an orthotopic model of metastatic TNBC. Metformin sensitized diverse TNBC cells to TRAIL receptor agonists. Metformin selectively enhanced the sensitivity of transformed breast epithelial cells to TRAIL receptor agonist-induced caspase activation and apoptosis with little effect on untransformed breast epithelial cells. These effects of metformin were accompanied by robust reductions in the protein levels of XIAP, a negative regulator of TRAIL-induced apoptosis. Silencing XIAP in TNBC cells mimicked the TRAIL-sensitizing effects of metformin. Metformin also enhanced the antitumor effects of TRAIL in a metastatic murine TNBC model. Our findings indicate that metformin enhances the activity of TRAIL receptor agonists, thereby supporting the rationale for additional translational studies combining these agents.

  16. Novel TRAIL sensitizer Taraxacum officinale F.H. Wigg enhances TRAIL-induced apoptosis in Huh7 cells.

    PubMed

    Yoon, Ji-Yong; Cho, Hyun-Soo; Lee, Jeong-Ju; Lee, Hyo-Jung; Jun, Soo Young; Lee, Jae-Hye; Song, Hyuk-Hwan; Choi, SangHo; Saloura, Vassiliki; Park, Choon Gil; Kim, Cheol-Hee; Kim, Nam-Soon

    2016-04-01

    TRAIL (TNF-related apoptosis inducing ligand) is a promising anti-cancer drug target that selectively induces apoptosis in cancer cells. However, many cancer cells are resistant to TRAIL-induced apoptosis. Therefore, reversing TRAIL resistance is an important step for the development of effective TRAIL-based anti-cancer therapies. We previously reported that knockdown of the TOR signaling pathway regulator-like (TIPRL) protein caused TRAIL-induced apoptosis by activation of the MKK7-c-Jun N-terminal Kinase (JNK) pathway through disruption of the MKK7-TIPRL interaction. Here, we identified Taraxacum officinale F.H. Wigg (TO) as a novel TRAIL sensitizer from a set of 500 natural products using an ELISA system and validated its activity by GST pull-down analysis. Furthermore, combination treatment of Huh7 cells with TRAIL and TO resulted in TRAIL-induced apoptosis mediated through inhibition of the MKK7-TIPRL interaction and subsequent activation of MKK7-JNK phosphorylation. Interestingly, HPLC analysis identified chicoric acid as a major component of the TO extract, and combination treatment with chicoric acid and TRAIL induced TRAIL-induced cell apoptosis via JNK activation due to inhibition of the MKK7-TIPRL interaction. Our results suggest that TO plays an important role in TRAIL-induced apoptosis, and further functional studies are warranted to confirm the importance of TO as a novel TRAIL sensitizer for cancer therapy. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

  17. Environmental Impact of a Submarine Cable: Case Study of the Acoustic Thermometry of Ocean Climate (ATOC)/ Pioneer Seamount Cable

    NASA Astrophysics Data System (ADS)

    Kogan, I.; Paull, C. K.; Kuhnz, L.; von Thun, S.; Burton, E.; Greene, H. G.; Barry, J. P.

    2003-12-01

    To better understand the potential impacts of the presence of cables on the seabed, a topic of interest for which little data is published or publicly available, a study of the environmental impacts of the ATOC/Pioneer Seamount cable was conducted. The 95 km long, submarine, coaxial cable extends between Pioneer Seamount and the Pillar Point Air Force Station in Half Moon Bay, California. Approximately two thirds of the cable lies within the Monterey Bay National Marine Sanctuary. The cable is permitted to NOAA- Oceanic and Atmospheric Research for transmitting data from a hydrophone array on Pioneer Seamount to shore. The cable was installed unburied on the seafloor in 1995. The cable path crosses the continental shelf, descends to a maximum depth of 1,933 m, and climbs back upslope to 998 m depth near the crest of Pioneer Seamount. A total of 42 hours of video and 152 push cores were collected in 10 stations along cable and control transects using the ROVs Ventana and Tiburon equipped with cable-tracking tools. The condition of the cable, its effect on the seafloor, and distribution of benthic megafauna and infauna were determined. Video data indicated the nature of interaction between the cable and the seafloor. Rocky nearshore areas, where wave energies are greatest, showed the clearest evidence of impact. Here, evidence of abrasion included frayed and unraveling portions of the cable's armor and vertical grooves in the rock apparently cut by the cable. The greatest incision and armor damage occurred on ledges between spans in irregular rock outcrop areas. Unlike the nearshore rocky region, neither the rocks nor the cable appeared damaged along outcrops on Pioneer Seamount. Multiple loops of slack cable added during a 1997 cable repair operation were found lying flat on the seafloor. Several sharp kinks in the cable were seen at 240 m water depths in an area subjected to intense trawling activity. Most of the cable has become buried with time in sediment substrates on the continental shelf whereas much of the cable remains exposed in sediments at deeper depths. The cable is exposed in rocky environments of the nearshore region and on all of Pioneer Seamount. The main biological features associated with the cable were organisms utilizing the cable as substrate and occasionally as shelter. Considerable care was taken to count megafauna in video transects and macrofauna from the top 5 cm of push cores. Few differences were found between cable and control sites at the 95% confidence level. Anemones Metridium farcimen and Stomphia sp. colonized the cable and were more abundant in cable transects at most soft sediment sites. Coarse extrapolation of the transect data suggest that more than 5,000 M. farcimen may live on the continental shelf portion of the cable. Several other species of anemones living on the cable are common along deeper sections of the cable route. Where the cable was buried, the presence of linear rows of sea anemones proved to be a reliable indicator of the cable's position. Flatfish and rockfish apparently congregate near the cable and were as much as 1 order of magnitude more abundant near the cable at some sites.

  18. 47 CFR 76.802 - Disposition of cable home wiring.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 4 2013-10-01 2013-10-01 false Disposition of cable home wiring. 76.802... MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Cable Inside Wiring § 76.802 Disposition of cable home wiring... cable operator shall not remove the cable home wiring unless it gives the subscriber the opportunity to...

  19. 47 CFR 76.802 - Disposition of cable home wiring.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 4 2014-10-01 2014-10-01 false Disposition of cable home wiring. 76.802... MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Cable Inside Wiring § 76.802 Disposition of cable home wiring... cable operator shall not remove the cable home wiring unless it gives the subscriber the opportunity to...

  20. 47 CFR 76.802 - Disposition of cable home wiring.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Disposition of cable home wiring. 76.802... MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Cable Inside Wiring § 76.802 Disposition of cable home wiring... cable operator shall not remove the cable home wiring unless it gives the subscriber the opportunity to...

  1. 47 CFR 76.802 - Disposition of cable home wiring.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 4 2012-10-01 2012-10-01 false Disposition of cable home wiring. 76.802... MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Cable Inside Wiring § 76.802 Disposition of cable home wiring... cable operator shall not remove the cable home wiring unless it gives the subscriber the opportunity to...

  2. 47 CFR 27.1202 - Cable/BRS cross-ownership.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... portion of the franchise area actually served by the cable operator's cable system and the cable operator... franchise area actually served by the cable operator's cable system the cable operator will use the BRS... that no portion of the GSA of the BRS station is within the portion of the franchise area actually...

  3. 47 CFR 27.1202 - Cable/BRS cross-ownership.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... portion of the franchise area actually served by the cable operator's cable system and the cable operator... franchise area actually served by the cable operator's cable system the cable operator will use the BRS... that no portion of the GSA of the BRS station is within the portion of the franchise area actually...

  4. 47 CFR 27.1202 - Cable/BRS cross-ownership.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... portion of the franchise area actually served by the cable operator's cable system and the cable operator... franchise area actually served by the cable operator's cable system the cable operator will use the BRS... that no portion of the GSA of the BRS station is within the portion of the franchise area actually...

  5. 47 CFR 27.1202 - Cable/BRS cross-ownership.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... portion of the franchise area actually served by the cable operator's cable system and the cable operator... franchise area actually served by the cable operator's cable system the cable operator will use the BRS... that no portion of the GSA of the BRS station is within the portion of the franchise area actually...

  6. Autophagy activation promotes removal of damaged mitochondria and protects against renal tubular injury induced by albumin overload.

    PubMed

    Tan, Jin; Wang, Miaohong; Song, Shuling; Miao, Yuyang; Zhang, Qiang

    2018-01-10

    Proteinuria (albuminuria) is an important cause of aggravating tubulointerstitial injury. Previous studies have shown that autophagy activation can alleviate renal tubular epithelial cell injury caused by urinary protein, but the mechanism is not clear. Here, we investigated the role of clearance of damaged mitochondria in this protective effect. We found that albumin overload induces a significant increase in turnover of LC3-II and decrease in p62 protein level in renal proximal tubular (HK-2) cells in vitro. Albumin overload also induces an increase in mitochondrial damage. ALC, a mitochondrial torpent, alleviates mitochondrial damage induced by albumin overload and also decreases autophagy, while mitochondrial damage revulsant CCCP further increases autophagy. Furthermore, pretreatment of HK-2 cells with rapamycin reduced the amount of damaged mitochondria and the level of apoptosis induced by albumin overload. In contrast, blocking autophagy with chloroquine exerted an opposite effect. Taken together, our results indicated autophagy activation promotes removal of damaged mitochondria and protects against renal tubular injury caused by albumin overload. This further confirms previous research that autophagy activation is an adaptive response in renal tubular epithelial cells after urinary protein overload.

  7. Torsion bar stabilizer for a vehicle and method for mounting the stabilizer on the vehicle frame

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sauber, C.J.

    This patent describes a method of mounting a stabilizing mechanism on a vehicle frame which is supported and biased on a suspension assembly at opposite sides of the frame. The frame includes overload stops riveted to opposite sides of the frame and the suspension assembly includes bracket assemblies which secure the vehicle's suspension springs to a wheel axle. The method comprises the following steps: removing an overload stop from each side of the vehicle frame; mounting a modified overload stop on each side of the frame which serves as both an overload stop and a support for the stabilizing mechanismmore » wherein the modified overload stop is mounted into the holes in the frame left from the removal of the overload stop; removing from each side of the vehicle the top bracket from the bracket assembly; inserting a modified top bracket into each bracket assembly wherein the top bracket assembly is modified to couple with the stabilizing mechanism; and mounting on the modified overload stops a torsion bar whose opposite ends are coupled to the modified top bracket by way of linkages.« less

  8. Long-term effect of dietary overload lithium on the glucose metabolism in broiler chickens.

    PubMed

    Bai, Shiping; Pan, Shuqin; Zhang, Keying; Ding, Xuemei; Wang, Jianping; Zeng, Qiufeng; Xuan, Yue; Su, Zuowei

    2017-09-01

    Lithium, like insulin, activates glycogen synthase and stimulates glucose transport in rat adipocytes. To investigate the effect of dietary overload lithium on glucose metabolism in broiler chickens, one-day-old chicks were fed a basal diet supplemented with 0 (control) or 100mg lithium/kg (overload lithium) for 35days. Compared to controls, glucose disappearance rates were lower (p=0.035) 15-120min after glucose gavage, and blood glucose concentrations were lower (p=0.038) 30min after insulin injection in overload lithium broilers. Overload lithium decreased (p<0.05) glycogen and glucose-6-phosphate concentrations in liver, but increased (p<0.05) their concentrations in pectoralis major. Overload lithium increased (p<0.05) mRNA expression of glucose transporter (GLUT) 3 and GLUT9 in liver, and GLUT1, GLUT3, GLUT8, and GLUT9 in pectoralis major, but decreased (p<0.05) cytosolic phosphoenolpyruvate carboxykinase (PEPCK) in liver and mitochondrial PEPCK in pectoralis major. These results suggest that dietary overload lithium decreases glucose tolerance and gluconeogenesis, but increases insulin sensitivity and glucose transport in broiler chickens. Copyright © 2017 Elsevier B.V. All rights reserved.

  9. Experimental Measurements and Comparison of Cable Performance for Mine Hunting Applications

    NASA Astrophysics Data System (ADS)

    Mangum, Katherine

    2005-11-01

    The Naval Surface Warfare Center (NSWCCD) conducted testing of multiple faired synthetic cables in the High Speed Basin in April, 2005. The objective of the test was to determine the hydrodynamic characteristics of bare cables, ribbon faired cables, and cables with extruded plastic ``strakes.'' Faired cables are used to gain on-station time and improve performance of the MH-60 Helicopter when towing mine hunting vehicles. Drag and strum were compared for all cases. Strum was quantified by computing standard deviations of lateral cable acceleration amplitudes. Drag coefficients were calculated using cable tension and angle readings. While the straked cables strummed less than the bare synthetic cable, they did not reduce strum levels as well as ribbon fairing at steep cable angles for speeds of 10, 15, 20 and 25 knots. The drag coefficient of the straked cables was calculated to be higher than that of a bare cable, although further testing is needed to determine an exact number.

  10. Development of Inspection Robots for Bridge Cables

    PubMed Central

    Kim, Se-Hoon; Lee, Jong-Jae

    2013-01-01

    This paper presents the bridge cable inspection robot developed in Korea. Two types of the cable inspection robots were developed for cable-suspension bridges and cable-stayed bridge. The design of the robot system and performance of the NDT techniques associated with the cable inspection robot are discussed. A review on recent advances in emerging robot-based inspection technologies for bridge cables and current bridge cable inspection methods is also presented. PMID:24459453

  11. Estimating the economic value and impacts of recreational trails: a case study of the Virginia creeper rail trail

    Treesearch

    J. Michael Bowker; John C. Bergstrom; Joshua Gill

    2007-01-01

    Many communities are interested in developing and maintaining recreational trails to benefit trail users and as tourist attractions to stimulate economic growth. In this paper, a study is described which estimates the net economic value to trail users and the local economic impacts of the Virginia Creeper Rail Trail in south-western Virginia, USA. The monetary...

  12. Trails at LANL - Public Meeting and Forum - July 26, 2016

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pava, Daniel Seth

    2016-07-26

    These are the slides of a meeting about trails at Los Alamos National Laboratory. The meeting goals are the folllowing: to inform and educate citizens about LANL trails management issues that include resource protection, safety, security and trails etiquette; to explain how and why LANL trails can be closed and reopened; and to understand your concerns and ideas about LANL trails use.

  13. A genome-wide loss-of-function screen identifies SLC26A2 as a novel mediator of TRAIL resistance

    PubMed Central

    Dimberg, Lina Y.; Towers, Christina G.; Behbakht, Kian; Hotz, Taylor J.; Kim, Jihye; Fosmire, Susan; Porter, Christopher C.; Tan, Aik-Choon; Thorburn, Andrew; Ford, Heide L.

    2017-01-01

    TNF-related apoptosis inducing ligand (TRAIL) is a potent death-inducing ligand that mediates apoptosis through the extrinsic pathway and serves as an important endogenous tumor suppressor mechanism. Because tumor cells are often killed by TRAIL and normal cells are not, drugs that activate the TRAIL pathway have been thought to have potential clinical value. However, to date, most TRAIL-related clinical trials have largely failed due to the tumor cells having intrinsic or acquired resistance to TRAIL-induced apoptosis. Previous studies to identify resistance mechanisms have focused on targeted analysis of the canonical apoptosis pathway and other known regulators of TRAIL receptor signaling. To identify novel mechanisms of TRAIL resistance in an unbiased way, we performed a genome wide shRNA screen for genes that regulate TRAIL sensitivity in sub-lines that had been selected for acquired TRAIL resistance. This screen identified previously unknown mediators of TRAIL resistance including Angiotensin II Receptor 2, Crk-like protein, T-Box Transcription Factor 2 and solute carrier family 26 member 2 (SLC26A2). SLC26A2 downregulates the TRAIL receptors, DR4 and DR5, and this downregulation is associated with resistance to TRAIL. Its expression is high in numerous tumor types compared to normal cells, and in breast cancer, SLC26A2 is associated with a significant decrease in relapse free survival. PMID:28108622

  14. Pressure overload differentially affects respiratory capacity in interfibrillar and subsarcolemmal mitochondria.

    PubMed

    Schwarzer, Michael; Schrepper, Andrea; Amorim, Paulo A; Osterholt, Moritz; Doenst, Torsten

    2013-02-15

    Years ago a debate arose as to whether two functionally different mitochondrial subpopulations, subsarcolemmal mitochondria (SSM) and interfibrillar mitochondria (IFM), exist in heart muscle. Nowadays potential differences are often ignored. Presumably, SSM are providing ATP for basic cell function, whereas IFM provide energy for the contractile apparatus. We speculated that two distinguishable subpopulations exist that are differentially affected by pressure overload. Male Sprague-Dawley rats were subjected to transverse aortic constriction for 20 wk or sham operation. Contractile function was assessed by echocardiography. Heart tissue was analyzed by electron microscopy. Mitochondria were isolated by differential centrifugation, and respiratory capacity was analyzed using a Clark electrode. Pressure overload induced left ventricular hypertrophy with increased posterior wall diameter and impaired contractile function. Mitochondrial state 3 respiration in control was 50% higher in IFM than in SSM. Pressure overload significantly impaired respiratory rates in both IFM and SSM, but in SSM to a lower extent. As a result, there were no differences between SSM and IFM after 20 wk of pressure overload. Pressure overload reduced total citrate synthase activity, suggesting reduced total mitochondrial content. Electron microscopy revealed normal morphology of mitochondria but reduced total mitochondrial volume density. In conclusion, IFM show greater respiratory capacity in the healthy rat heart and a greater depression of respiratory capacity by pressure overload than SSM. The differences in respiratory capacity of cardiac IFM and SSM in healthy hearts are eliminated with pressure overload-induced heart failure. The strong effect of pressure overload on IFM together with the simultaneous appearance of mitochondrial and contractile dysfunction may support the notion of IFM primarily producing ATP for contractile function.

  15. Dietary overload lithium decreases the adipogenesis in abdominal adipose tissue of broiler chickens.

    PubMed

    Bai, Shiping; Pan, Shuqin; Zhang, Keying; Ding, Xuemei; Wang, Jianping; Zeng, Qiufeng; Xuan, Yue; Su, Zuowei

    2017-01-01

    To investigate the toxic effects of dietary overload lithium on the adipogenesis in adipose tissue of chicken and the role of hypothalamic neuropeptide Y (NPY) in this process, one-day-old male chicks were fed with the basal diet added with 0 (control) or 100mg lithium/kg diet from lithium chloride (overload lithium) for 35days. Abdominal adipose tissue and hypothalamus were collected at day 6, 14, and 35. As a percentage of body weight, abdominal fat decreased (p<0.001) at day 6, 14, and 35, and feed intake and body weight gain decreased during day 7-14, and day 15-35 in overload lithium treated broilers as compared to control. Adipocyte diameter and DNA content in abdominal adipose tissue were significantly lower in overload-lithium treatment than control at day 35, although no significant differences were observed at day 6 and 14. Dietary overload lithium decreased (p<0.01) transcriptional expression of preadipocyte proliferation makers ki-67 (KI67), microtubule-associated protein homolog (TPX2), and topoisomerase 2-alpha (TOP2A), and preadipocyte differentiation transcriptional factors peroxisome proliferator-activated receptor-γ (PPARγ), and CCAAT/enhancer binding protein (C/EBP) α mRNA abundance in abdominal adipose tissue. In hypothalamus, dietary overload lithium influenced (p<0.001) NPY, and NPY receptor (NPYR) 6 mRNA abundance at day 6 and 14, but not at day 35. In conclusion, dietary overload lithium decreased the adipogenesis in abdominal adipose tissue of chicken, which was accompanied by depressing transcriptional expression of adipogenesis-associated factors. Hypothalamic NPY had a potential role in the adipogenesis in abdominal adipose tissue of broilers with a short-term overload lithium treatment. Copyright © 2016 Elsevier B.V. All rights reserved.

  16. Effects of pressure- or volume-overload hypertrophy on passive stiffness in isolated adult cardiac muscle cells

    NASA Technical Reports Server (NTRS)

    Kato, S.; Koide, M.; Cooper, G. 4th; Zile, M. R.

    1996-01-01

    It has been hypothesized that the changes in myocardial stiffness induced by chronic hemodynamic overloading are dependent on changes in the passive stiffness of the cardiac muscle cell (cardiocyte). However, no previous studies have examined the passive constitutive properties of cardiocytes isolated from animals with myocardial hypertrophy. Accordingly, changes in relative passive stiffness of cardiocytes isolated from animals with chronic pressure- or volume-overload hypertrophy were determined by examining the effects of anisosmotic stress on cardiocyte size. Anisosmotic stress was produced by altering superfusate osmolarity. Hypertrophied cardiocytes were enzymatically isolated from 16 adult cats with right ventricular (RV) pressure-overload hypertrophy induced by pulmonary artery banding (PAB) and from 6 adult cats with RV volume-overload hypertrophy induced by creating an atrial septal defect (ASD). Left ventricular (LV) cardiocytes from each cat served as nonhypertrophied, normally loaded, same-animal controls. Superfusate osmolarity was decreased from 305 +/- 3 to 135 +/- 5 mosM and increased to 645 +/- 4 mosM. During anisosmotic stress, there were no significant differences between hypertrophied RV and normal LV cardiocytes in pressure overload PAB cats with respect to percent change in cardiocyte area (47 +/- 2% in RV vs. 48 +/- 2% in LV), diameter (46 +/- 3% in RV vs. 48 +/- 2% in LV), or length (2.4 +/- 0.2% in RV vs. 2.0 +/- 0.3% in LV), or sarcomere length (1.5 +/- 0.1% in RV vs. 1.3 +/- 0.3% in LV). Likewise, there were no significant differences in cardiocyte strain between hypertrophied RV and normal LV cardiocytes from ASD cats. In conclusion, chronic pressure-overload hypertrophy and chronic volume-overload hypertrophy did not alter the cardiocyte response to anisosmotic stress. Thus chronic overload hypertrophy did not alter relative passive cardiocyte stiffness.

  17. Nicotinamide N‐methyltransferase expression decreases in iron overload, exacerbating toxicity in mouse hepatocytes

    PubMed Central

    Koppe, Tiago; Patchen, Bonnie; Cheng, Aaron; Bhasin, Manoj; Vulpe, Chris; Schwartz, Robert E.; Moreno‐Navarrete, Jose Maria; Fernandez‐Real, Jose Manuel

    2017-01-01

    Iron overload causes the generation of reactive oxygen species that can lead to lasting damage to the liver and other organs. The goal of this study was to identify genes that modify the toxicity of iron overload. We studied the effect of iron overload on the hepatic transcriptional and metabolomic profile in mouse models using a dietary model of iron overload and a genetic model, the hemojuvelin knockout mouse. We then evaluated the correlation of nicotinamide N‐methyltransferase (NNMT) expression with body iron stores in human patients and the effect of NNMT knockdown on gene expression and viability in primary mouse hepatocytes. We found that iron overload induced significant changes in the expression of genes and metabolites involved in glucose and nicotinamide metabolism and that NNMT, an enzyme that methylates nicotinamide and regulates hepatic glucose and cholesterol metabolism, is one of the most strongly down‐regulated genes in the liver in both genetic and dietary iron overload. We found that hepatic NNMT expression is inversely correlated with serum ferritin levels and serum transferrin saturation in patients who are obese, suggesting that body iron stores regulate human liver NNMT expression. Furthermore, we demonstrated that adenoviral knockdown of NNMT in primary mouse hepatocytes exacerbates iron‐induced hepatocyte toxicity and increases expression of transcriptional markers of oxidative and endoplasmic reticulum stress, while overexpression of NNMT partially reversed these effects. Conclusion: Iron overload alters glucose and nicotinamide transcriptional and metabolic pathways in mouse hepatocytes and decreases NNMT expression, while NNMT deficiency worsens the toxic effect of iron overload. For these reasons, NNMT may be a drug target for the prevention of iron‐induced hepatotoxicity. (Hepatology Communications 2017;1:803–815) PMID:29404495

  18. The efficacy of combined educational and site management actions in reducing off-trail hiking in an urban-proximate protected area.

    PubMed

    Hockett, Karen S; Marion, Jeffrey L; Leung, Yu-Fai

    2017-12-01

    Park and protected area managers are tasked with protecting natural environments, a particularly daunting challenge in heavily visited urban-proximate areas where flora and fauna are already stressed by external threats. In this study, an adaptive management approach was taken to reduce extensive off-trail hiking along a popular trail through an ecologically diverse and significant area in the Chesapeake and Ohio National Historical Park near Washington DC. Substantial amounts of off-trail hiking there had created an extensive 16.1 km network of informal (visitor-created) trails on a 39 ha island in the Potomac Gorge. A research design with additive treatments integrating educational and site management actions was applied and evaluated using self-reported behavior from an on-site visitor survey and unobtrusive observations of off-trail hiking behavior at two locations along the trail. Study treatments included: 1) trailhead educational signs developed using attribution theory and injunctive-proscriptive wording, 2) symbolic "no hiking" prompter signs attached to logs placed across all informal trails, 3) placement of concealing leaf litter and small branches along initial sections of informal trails, 4) restoration work on selected trails with low fencing, and 5) contact with a trail steward to personally communicate the trailhead sign information. The final, most comprehensive treatment reduced visitor-reported intentional off-trail hiking from 70.3% to 43.0%. Direct observations documented reduction in off-trail hiking from 25.9% to 2.0%. The educational message and site management actions both contributed to the decline in off-trail travel and the two evaluation methods enhanced our ability to describe the efficacy of the different treatments in reducing off-trail travel. Published by Elsevier Ltd.

  19. Validation of Walking Trails for the Urban Training™ of Chronic Obstructive Pulmonary Disease Patients.

    PubMed

    Arbillaga-Etxarri, Ane; Torrent-Pallicer, Jaume; Gimeno-Santos, Elena; Barberan-Garcia, Anael; Delgado, Anna; Balcells, Eva; Rodríguez, Diego A; Vilaró, Jordi; Vall-Casas, Pere; Irurtia, Alfredo; Rodriguez-Roisin, Robert; Garcia-Aymerich, Judith

    2016-01-01

    Accessible interventions to train patients with chronic obstructive pulmonary disease (COPD) are needed. We designed urban trails of different intensities (low, moderate and high) in different types of public spaces (boulevard, beach and park). We aimed to validate the trails' design by assessing the physiological response to unsupervised walking trails of: (1) different intensities in COPD patients, and (2) same intensity from different public spaces in healthy adults. On different days and under standardized conditions, 10 COPD patients walked the three intensity trails designed in a boulevard space, and 10 healthy subjects walked the three intensity trails in three different spaces. We measured physiological response and energy expenditure using a gas analyzer. We compared outcomes across trails intensity and/or spaces using mixed-effects linear regression. In COPD patients, physiological response and energy expenditure increased significantly according to the trails intensity: mean (SD) peak V̇O2 15.9 (3.5), 17.4 (4.7), and 17.7 (4.4) mL/min/kg (p-trend = 0.02), and MET-min 60 (23), 64 (26), 72 (31) (p-trend<0.01) in low, moderate and high intensity trails, respectively. In healthy subjects there were no differences in physiological response to walking trails of the same intensity across different spaces. We validated the trails design for the training of COPD patients by showing that the physiological response to and energy expenditure on unsupervised walking these trails increased according to the predefined trails' intensity and did not change across trails of the same intensity in different public space. Walkable public spaces allow the design of trails that could be used for the training of COPD patients in the community.

  20. The efficacy of combined educational and site management actions in reducing off-trail hiking in an urban-proximate protected area

    USGS Publications Warehouse

    Hockett, Karen; Marion, Jeff; Leung, Yu-Fai

    2017-01-01

    Park and protected area managers are tasked with protecting natural environments, a particularly daunting challenge in heavily visited urban-proximate areas where flora and fauna are already stressed by external threats. In this study, an adaptive management approach was taken to reduce extensive off-trail hiking along a popular trail through an ecologically diverse and significant area in the Chesapeake and Ohio National Historical Park near Washington DC. Substantial amounts of off-trail hiking there had created an extensive 16.1 km network of informal (visitor-created) trails on a 39 ha island in the Potomac Gorge. A research design with additive treatments integrating educational and site management actions was applied and evaluated using self-reported behavior from an on-site visitor survey and unobtrusive observations of off-trail hiking behavior at two locations along the trail. Study treatments included: 1) trailhead educational signs developed using attribution theory and injunctive-proscriptive wording, 2) symbolic “no hiking” prompter signs attached to logs placed across all informal trails, 3) placement of concealing leaf litter and small branches along initial sections of informal trails, 4) restoration work on selected trails with low fencing, and 5) contact with a trail steward to personally communicate the trailhead sign information. The final, most comprehensive treatment reduced visitor-reported intentional off-trail hiking from 70.3% to 43.0%. Direct observations documented reduction in off-trail hiking from 25.9% to 2.0%. The educational message and site management actions both contributed to the decline in off-trail travel and the two evaluation methods enhanced our ability to describe the efficacy of the different treatments in reducing off-trail travel.

  1. 3-Bromopyruvate enhances TRAIL-induced apoptosis in human nasopharyngeal carcinoma cells through CHOP-dependent upregulation of TRAIL-R2.

    PubMed

    Can, Zhou; Lele, Song; Zhirui, Zhang; Qiong, Pan; Yuzhong, Chen; Lingling, Liu; Surong, Zhao; Yiming, Sun; Pei, Zhang; Chenchen, Jiang; Liu, Hao

    2017-08-01

    Past reports have shown that the sensitivity of cancer cells to TRAIL-induced apoptosis is related to their expression of TRAIL-death receptors on the cell surface. However, the level of TRAIL-death receptors expression on cancer cells is always low. Our previous research showed that nasopharyngeal carcinoma (NPC) cells have a poor sensitivity to low doses of TRAIL. Here, we evaluated combined treatment with the energy inhibitor 3-bromopyruvate (3BP) and TRAIL as a method to produce an increased apoptotic response in NPC cells. The results showed that 3BP and TRAIL together produced higher cytotoxicity and increased TRAIL-R2 expression in NPC cells compared with the effects of either 3BP or TRAIL alone. These findings led us to hypothesize that 3BP may sensitize NPC cells to TRAIL. 3BP is a metabolic blocker that inhibits hexokinase II activity, suppresses ATP production, and induces endoplasmic reticulum (ER) stress. Our results showed that 3BP also activated AMP-activated protein kinase, which we found to play an important role in the induction of ER stress by 3BP. Furthermore, the induction of TRAIL-R2 expression and the sensitization of the NPC cells to TRAIL by 3BP were reduced when we inhibited the expression of CHOP. Taken together, our results showed that a low dose of 3BP sensitized NPC cells to TRAIL-induced apoptosis by the upregulation of CHOP, which was mediated by the activation of AMP-activated protein kinase and ER stress. The results showed that 3BP is a promising candidate agent for enhancing the therapeutic response to TRAIL in NPC.

  2. The novel thymidylate synthase inhibitor trifluorothymidine (TFT) and TRAIL synergistically eradicate non-small cell lung cancer cells.

    PubMed

    Azijli, Kaamar; van Roosmalen, Ingrid A M; Smit, Jorn; Pillai, Saravanan; Fukushima, Masakazu; de Jong, Steven; Peters, Godefridus J; Bijnsdorp, Irene V; Kruyt, Frank A E

    2014-06-01

    TRAIL, a tumor selective anticancer agent, may be used for the treatment of non-small cell lung cancer (NSCLC). However, TRAIL resistance is frequently encountered. Here, the combined use of TRAIL with trifluorothymidine (TFT), a thymidylate synthase inhibitor, was examined for sensitizing NSCLC cells to TRAIL. Interactions between TRAIL and TFT were studied in NSCLC cells using growth inhibition and apoptosis assays. Western blotting and flow cytometry were used to investigate underlying mechanisms. The combined treatment of TFT and TRAIL showed synergistic cytotoxicity in A549, H292, H322 and H460 cells. For synergistic activity, the sequence of administration was important; TFT treatment followed by TRAIL exposure did not show sensitization. Combined TFT and TRAIL treatment for 24 h followed by 48 h of TFT alone was synergistic in all cell lines, with combination index values below 0.9. The treatments affected cell cycle progression, with TRAIL inducing a G1 arrest and TFT, a G2/M arrest. TFT activated Chk2 and reduced Cdc25c levels known to cause G2/M arrest. TRAIL-induced caspase-dependent apoptosis was enhanced by TFT, whereas TFT alone mainly induced caspase-independent death. TFT increased the expression of p53 and p21/WAF1, and p53 was involved in the increase of TRAIL-R2 surface expression. TFT also caused downregulation of cFLIP and XIAP and increased Bax expression. TFT enhances TRAIL-induced apoptosis in NSCLC cells by sensitizing the apoptotic machinery at different levels in the TRAIL pathway. Our findings suggest a possible therapeutic benefit of the combined use of TFT and TRAIL in NSCLC.

  3. 47 CFR 36.153 - Assignment of Cable and Wire Facilities (C&WF) to categories.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Assignment of Cable and Wire Facilities (C&WF... Telecommunications Property Cable and Wire Facilities § 36.153 Assignment of Cable and Wire Facilities (C&WF) to... cable and intrabuilding network cable. Where an entire cable or aerial wire is assignable to one...

  4. 47 CFR 36.153 - Assignment of Cable and Wire Facilities (C&WF) to categories.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Assignment of Cable and Wire Facilities (C&WF... Telecommunications Property Cable and Wire Facilities § 36.153 Assignment of Cable and Wire Facilities (C&WF) to... cable and intrabuilding network cable. Where an entire cable or aerial wire is assignable to one...

  5. Incidentally Detected Transfusion-associated Iron Overload in 3 Children After Cancer Chemotherapy.

    PubMed

    Kuo, Dennis John; Bhagia, Pooja

    2018-04-01

    Iron overload is a potential long-term complication among cancer survivors who received transfusions during treatment. Although there are screening guidelines for iron overload in pediatric survivors of hematopoietic stem cell transplant, these do not call for screening of other pediatric oncology patients. In our practice we incidentally discovered 3 patients in a population of 168 cancer survivors over the span of 17 years who were treated for cancer without hematopoietic stem cell transplant who had iron overload. The 3 patients had elevated liver iron on magnetic resonance imaging T2* and 2 received therapeutic phlebotomy. These cases, and others like them, suggest that collaborative groups should consider revisiting the literature to establish screening and treatment guidelines for iron overload after cancer therapy.

  6. Damping Estimation from Free Decay Responses of Cables with MR Dampers.

    PubMed

    Weber, Felix; Distl, Hans

    2015-01-01

    This paper discusses the damping measurements on cables with real-time controlled MR dampers that were performed on a laboratory scale single strand cable and on cables of the Sutong Bridge, China. The control approach aims at producing amplitude and frequency independent cable damping which is confirmed by the tests. The experimentally obtained cable damping in comparison to the theoretical value due to optimal linear viscous damping reveals that support conditions of the cable anchors, force tracking errors in the actual MR damper force, energy spillover to higher modes, and excitation and sensor cables hanging on the stay cable must be taken into consideration for the interpretation of the identified cable damping values.

  7. Damping Estimation from Free Decay Responses of Cables with MR Dampers

    PubMed Central

    Weber, Felix; Distl, Hans

    2015-01-01

    This paper discusses the damping measurements on cables with real-time controlled MR dampers that were performed on a laboratory scale single strand cable and on cables of the Sutong Bridge, China. The control approach aims at producing amplitude and frequency independent cable damping which is confirmed by the tests. The experimentally obtained cable damping in comparison to the theoretical value due to optimal linear viscous damping reveals that support conditions of the cable anchors, force tracking errors in the actual MR damper force, energy spillover to higher modes, and excitation and sensor cables hanging on the stay cable must be taken into consideration for the interpretation of the identified cable damping values. PMID:26167537

  8. Analysis of the impact of recreational trail usage for prioritising management decisions: a regression tree approach

    NASA Astrophysics Data System (ADS)

    Tomczyk, Aleksandra; Ewertowski, Marek; White, Piran; Kasprzak, Leszek

    2016-04-01

    The dual role of many Protected Natural Areas in providing benefits for both conservation and recreation poses challenges for management. Although recreation-based damage to ecosystems can occur very quickly, restoration can take many years. The protection of conservation interests at the same as providing for recreation requires decisions to be made about how to prioritise and direct management actions. Trails are commonly used to divert visitors from the most important areas of a site, but high visitor pressure can lead to increases in trail width and a concomitant increase in soil erosion. Here we use detailed field data on condition of recreational trails in Gorce National Park, Poland, as the basis for a regression tree analysis to determine the factors influencing trail deterioration, and link specific trail impacts with environmental, use related and managerial factors. We distinguished 12 types of trails, characterised by four levels of degradation: (1) trails with an acceptable level of degradation; (2) threatened trails; (3) damaged trails; and (4) heavily damaged trails. Damaged trails were the most vulnerable of all trails and should be prioritised for appropriate conservation and restoration. We also proposed five types of monitoring of recreational trail conditions: (1) rapid inventory of negative impacts; (2) monitoring visitor numbers and variation in type of use; (3) change-oriented monitoring focusing on sections of trail which were subjected to changes in type or level of use or subjected to extreme weather events; (4) monitoring of dynamics of trail conditions; and (5) full assessment of trail conditions, to be carried out every 10-15 years. The application of the proposed framework can enhance the ability of Park managers to prioritise their trail management activities, enhancing trail conditions and visitor safety, while minimising adverse impacts on the conservation value of the ecosystem. A.M.T. was supported by the Polish Ministry of Science and Higher Education under Grant 927/MOB/2012/0 ("Mobility Plus" program). P.C.L. White received funding under a UK Natural Environment Research Council grant (NE/K001620/1), with support from the Biodiversity and Ecosystem Service Sustainability (BESS) programme. BESS is a six-year programme (2011-2017) funded by the UK Natural Environment Research Council (NERC) and the Biotechnology and Biological Sciences Research Council (BBSRC) as part of the UK's Living with Environmental Change. (LWEC) programme.

  9. Trail-following behavior ofReticulitermes hesperus Banks (Isoptera: Rhinotermitidae).

    PubMed

    Grace, J K; Wood, D L; Frankie, G W

    1988-02-01

    The behavior ofReticulitermes hesperus Banks pseudergates (workers) was assessed on artificial trails containing different concentrations of sternal gland extract. On nongiadient trails, more pseudergates were recruited to trails of greater pheromone concentration, they traveled a greater distance without pausing, and their rate of locomotion increased over that observed on trails of lesser concentration (positive orthokinesis). Of the individuals pausing before completing trails of high concentration, fewer left the trails or reversed direction (negative klinokinesis) than on trails of lower concentration. Termites walking down concentration gradients failed to complete these trails to the low-concentration termini. At a point representing an average decrease of slightly more than 10-fold in the original concentration of pheromone, individuals reversed their direction of travel and returned to the high-concentration terminus. Termites walking up pheromone gradients proceeded to the high-concentration termini without reversing direction.R. hesperus pseudergates are thus able to orient along a gradient of trail pheromone by longitudinal klinotaxis.

  10. Assessing the influence of sustainable trail design and maintenance on soil loss

    USGS Publications Warehouse

    Marion, Jeff; Wimpey, Jeremy

    2017-01-01

    Natural-surfaced trail systems are an important infrastructure component providing a means for accessing remote protected natural area destinations. The condition and usability of trails is a critical concern of land managers charged with providing recreational access while preserving natural conditions, and to visitors seeking high quality recreational opportunities and experiences. While an adequate number of trail management publications provide prescriptive guidance for designing, constructing, and maintaining natural-surfaced trails, surprisingly little research has been directed at providing a scientific basis for this guidance. Results from a review of the literature and three scientific studies are presented to model and clarify the influence of factors that substantially influence trail soil loss and that can be manipulated by trail professionals to sustain high traffic while minimizing soil loss over time. Key factors include trail grade, slope alignment angle, tread drainage features, and the amount of rock in tread substrates. A new Trail Sustainability Rating is developed and offered as a tool for evaluating or improving the sustainability of existing or new trails.

  11. Overload protection for switching regulators

    NASA Technical Reports Server (NTRS)

    Lachochi, E.

    1980-01-01

    Circuit protects all output lines of switching regulator against overloads without requiring current sensors on every line. If overload is sensed, device short circuits bias on switching transistor so that power is rapidly cut off from loads. Circuit also includes delay network to inhibit erroneous operation during startup.

  12. The Mythology of Information Overload.

    ERIC Educational Resources Information Center

    Tidline, Tonyia J.

    1999-01-01

    Combines ideas from mythology, folklore, and library and information science to conclude that information overload is a myth of modern culture. Reports results of a pilot project intended to describe information overload experienced by a particular folk group composed of future library and information professionals. (Author/LRW)

  13. Deferasirox : a review of its use in the management of transfusional chronic iron overload.

    PubMed

    Yang, Lily P H; Keam, Susan J; Keating, Gillian M

    2007-01-01

    Deferasirox (Exjade) is an oral, once-daily iron chelator widely approved for the treatment of transfusional chronic iron overload. In the EU, deferasirox is indicated in patients with beta-thalassaemia major aged > or =6 years and, in the US, in all transfusional chronic iron overload patients aged > or =2 years. Deferasirox is highly selective for iron as Fe3+. In approximately 1-year clinical trials of patients with transfusional chronic iron overload associated with beta-thalassaemia, sickle cell disease, myelodysplastic syndrome or other rare chronic anaemias, deferasirox 20 or 30 mg/kg/day had a beneficial effect on liver iron concentrations (LIC) and serum ferritin levels; tolerability issues were clinically manageable with regular patient monitoring. Although longer-term efficacy and tolerability data are required, in particular examining the prevention of iron overload-related complications and the effect of deferasirox on renal function, deferasirox is an easily administered iron chelator and is a valuable option in the management of transfusional chronic iron overload.

  14. Diagnosis and treatment of cardiac iron overload in transfusion-dependent thalassemia patients.

    PubMed

    Siri-Angkul, Natthaphat; Chattipakorn, Siriporn C; Chattipakorn, Nipon

    2018-05-18

    Thalassemia is among the most common genetic diseases. Patients with severe forms of the disease are transfusion-dependent, leading to iron overload. A condition which can eventually develop in the iron-loaded heart is iron overload cardiomyopathy, a debilitating disease that accounts for the majority of deaths in thalassemia patients. Areas covered: This review article provides a comprehensive summary of the diagnosis and treatment of cardiac iron overload in transfusion-dependent thalassemia patients, with discussion covering current weak points and potential improvements of the relevant diagnostic and therapeutic strategies. Expert commentary: Current limitations of various diagnostic techniques for iron overload cardiomyopathy include suboptimal accuracy, untimely detection, or inadequate accessibility, and novel modalities are required to overcome these shortcomings. Treatment should address key pathophysiologic mechanisms of iron overload cardiomyopathy, which include cardiac iron mishandling and iron-induced oxidative injury. Apart from the promotion of iron removal by chelators, prevention of cardiac iron deposition and attenuation of oxidative damage should also be rigorously investigated on a cell-to-bedside basis.

  15. Iron overload and chelation therapy in myelodysplastic syndromes.

    PubMed

    Temraz, Sally; Santini, Valeria; Musallam, Khaled; Taher, Ali

    2014-07-01

    Iron overload remains a concern in MDS patients especially those requiring recurrent blood transfusions. The consequence of iron overload may be more relevant in patients with low and intermediate-1 risk MDS who may survive long enough to experience such manifestations. It is a matter of debate whether this overload has time to yield organ damage, but it is quite evident that cellular damage and DNA genotoxic effect are induced. Iron overload may play a critical role in exacerbating pre-existing morbidity or even unmask silent ones. Under these circumstances, iron chelation therapy could play an integral role in the management of these patients. This review entails an in depth analysis of iron overload in MDS patients; its pathophysiology, effect on survival, associated risks and diagnostic options. It also discusses management options in relation to chelation therapy used in MDS patients and the impact it has on survival, hematologic response and organ function. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  16. TNF-related apoptosis-inducing ligand (TRAIL): A new path to anti-cancer therapies

    PubMed Central

    Holoch, Peter A.; Griffith, Thomas S.

    2009-01-01

    Since its discovery in 1995, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a member of the tumor necrosis factor super family, has been under intense focus because of its remarkable ability to induce apoptosis in malignant human cells while leaving normal cells unscathed. Consequently, activation of the apoptotic signaling pathway from the death-inducing TRAIL receptors provides an attractive, biologically-targeted approach to cancer therapy. A great deal of research has focused on deciphering the TRAIL receptor signaling cascade and intracellular regulation of this pathway, as many human tumor cells possess mechanisms of resistance to TRAIL-induced apoptosis. This review focuses on the currently state of knowledge regarding TRAIL signaling and resistance, the preclinical development of therapies targeted at TRAIL receptors and modulators of the pathway, and the results of clinical trials for cancer treatment that have emerged from this base of knowledge. TRAIL-based approaches to cancer therapy vary from systemic administration of recombinant, soluble TRAIL protein with or without the combination of traditional chemotherapy, radiation or novel anticancer agents to agonistic monoclonal antibodies directed against functional TRAIL receptors to TRAIL gene transfer therapy. A better understanding of TRAIL resistance mechanisms may allow for the development of more effective therapies that exploit this cell-mediated pathway to apoptosis. PMID:19836385

  17. Comparison study of cable geometries and superconducting tape layouts for high-temperature superconductor cables

    NASA Astrophysics Data System (ADS)

    Ta, Wurui; Shao, Tianchong; Gao, Yuanwen

    2018-04-01

    High-temperature superconductor (HTS) rare-earth-barium-copper-oxide (REBCO) tapes are very promising for use in high-current cables. The cable geometry and the layout of the superconducting tapes are directly related to the performance of the HTS cable. In this paper, we use numerical methods to perform a comparison study of multiple-stage twisted stacked-tape cable (TSTC) conductors to find better cable structures that can both improve the critical current and minimize the alternating current (AC) losses of the cable. The sub-cable geometry is designed to have a stair-step shape. Three superconducting tape layouts are chosen and their transport performance and AC losses are evaluated. The magnetic field and current density profiles of the cables are obtained. The results show that arrangement of the superconducting tapes from the interior towards the exterior of the cable based on their critical current values in descending order can enhance the cable's transport capacity while significantly reducing the AC losses. These results imply that cable transport capacity improvements can be achieved by arranging the superconducting tapes in a manner consistent with the electromagnetic field distribution. Through comparison of the critical currents and AC losses of four types of HTS cables, we determine the best structural choice among these cables.

  18. Association Between Fluid Balance and Outcomes in Critically Ill Children: A Systematic Review and Meta-analysis.

    PubMed

    Alobaidi, Rashid; Morgan, Catherine; Basu, Rajit K; Stenson, Erin; Featherstone, Robin; Majumdar, Sumit R; Bagshaw, Sean M

    2018-03-01

    After initial resuscitation, critically ill children may accumulate fluid and develop fluid overload. Accruing evidence suggests that fluid overload contributes to greater complexity of care and worse outcomes. To describe the methods to measure fluid balance, define fluid overload, and evaluate the association between fluid balance and outcomes in critically ill children. Systematic search of MEDLINE, EMBASE, Cochrane Library, trial registries, and selected gray literature from inception to March 2017. Studies of children admitted to pediatric intensive care units that described fluid balance or fluid overload and reported outcomes of interest were included. No language restrictions were applied. All stages were conducted independently by 2 reviewers. Data extracted included study characteristics, population, fluid metrics, and outcomes. Risk of bias was assessed using the Newcastle-Ottawa Scale. Narrative description of fluid assessment methods and fluid overload definitions was done. When feasible, pooled analyses were performed using random-effects models. Mortality was the primary outcome. Secondary outcomes included treatment intensity, organ failure, and resource use. A total of 44 studies (7507 children) were included in this systematic review and meta-analysis. Of those, 27 (61%) were retrospective cohort studies, 13 (30%) were prospective cohort studies, 3 (7%) were case-control studies, and 1 study (2%) was a secondary analysis of a randomized trial. The proportion of children with fluid overload varied by case mix and fluid overload definition (median, 33%; range, 10%-83%). Fluid overload, however defined, was associated with increased in-hospital mortality (17 studies [n = 2853]; odds ratio [OR], 4.34 [95% CI, 3.01-6.26]; I2 = 61%). Survivors had lower percentage fluid overload than nonsurvivors (22 studies [n = 2848]; mean difference, -5.62 [95% CI, -7.28 to -3.97]; I2 = 76%). After adjustment for illness severity, there was a 6% increase in odds of mortality for every 1% increase in percentage fluid overload (11 studies [n = 3200]; adjusted OR, 1.06 [95% CI, 1.03-1.10]; I2 = 66%). Fluid overload was associated with increased risk for prolonged mechanical ventilation (>48 hours) (3 studies [n = 631]; OR, 2.14 [95% CI, 1.25-3.66]; I2 = 0%) and acute kidney injury (7 studies [n = 1833]; OR, 2.36 [95% CI, 1.27-4.38]; I2 = 78%). Fluid overload is common and is associated with substantial morbidity and mortality in critically ill children. Additional research should now ideally focus on interventions aimed to mitigate the potential for harm associated with fluid overload.

  19. Assessing trail conditions in protected areas: Application of a problem-assessment method in Great Smoky Mountains National Park, USA

    USGS Publications Warehouse

    Leung, Y.-F.; Marion, J.

    1999-01-01

    The degradation of trail resources associated with expanding recreation and tourism visitation is a growing management problem in protected areas worldwide. In order to make judicious trail and visitor management decisions, protected area managers need objective and timely information on trail resource conditions. This paper introduces a trail survey method that efficiently characterizes the lineal extent of common trail problems. The method was applied to a large sample of trails within Great Smoky Mountains National Park, a highuse protected area in the USA. The Trail ProblemAssessment Method (TPAM) employs a continuous search for multiple indicators of predefined tread problems, yielding census data documenting the location, occurrence and extent of each problem. The present application employed 23 different indicators in three categories to gather inventory, resource condition, and design and maintenance data of each surveyed trail. Seventy-two backcountry hiking trails (528 km), or 35% of the Park's total trail length, were surveyed. Soil erosion and wet soil were found to be the two most common impacts on a lineal extent basis. Trails with serious tread problems were well distributed throughout the Park, although wet muddy treads tended to be concentrated in areas where horse use was high. The effectiveness of maintenance features installed to divert water from trail treads was also evaluated. Water bars were found to be more effective than drainage dips. The TPAM was able to provide Park managers with objective and quantitative information for use in trail planning, management and maintenance decisions, and is applicable to other protected areas elsewhere with different environmental and impact characteristics.

  20. Crystal River 3 Cable Materials for Thermal and Gamma Radiation Aging

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fifield, Leonard S.; Correa, Miguel; Zwoster, Andy

    The Expanded Materials Degradation Assessment Volume 5: Aging of Cables and Cable Systems (EMDA) summarizes the state of knowledge of materials, constructions, operating environments, and aging behavior of low voltage and medium cables in nuclear power plants (NPPs) and identifies potential knowledge gaps with regard to cable operation beyond 60 years. The greatest area of uncertainty relates to how well the accelerated aging used in the original equipment qualification (EQ) processes predicts the performance of cable materials in extended operation. General opinion and utility experience have indicated that actual operating environments of in-plant cables are not as severe, however, asmore » the operating and design basis environments used in the qualification process. Better understanding of the long term aging behavior of cable insulation materials in service conditions and the analysis of actual cable operating environments are the objectives of ongoing research to support subsequent license renewal activities in particular and long term cable aging management in general. A key component of the effort to better understand cable material aging behavior is the availability of representative samples of cables that have been installed in operating light water reactors and have experienced long term service. Unique access to long term service cables, including relatively rich information on cable identity and history, occurred in 2016 through the assistance of the Electric Power Research Institute (EPRI). EPRI facilitated DOE receipt of harvested cables from the decommissioned Crystal River Unit 3 (CR3) pressurized water reactor representing six of the nine most common low voltage cable manufacturers (EPRI 103841R1): Rockbestos, Anaconda Wire and Cable Company (Anaconda), Boston Insulated Wire (BIW), Brand-Rex, Kerite and Okonite. Cable samples received had been installed in the operating plant for durations ranging from 10 years to 36 years. These cables provide the opportunity to assess actual in-plant material aging and compare it to the expectations for service aging implied in original equipment qualification. The received samples are from cables manufactured as early as 1971 and as late as 1998. Of the original manufacturers, BIW, Anaconda and Kerite no longer supply low-voltage cables to the nuclear industry. Okonite, Rockbestos, and Brand-Rex do still supply nuclear-grade low-voltage cables, but most cable insulation formulations have changed over the years. Thus the availability of the CR3 samples representative of cables installed in existing U.S. NPPs also presents the opportunity for additional aging studies on the most relevant insulation and jacketing materials. This report describes the cables received from CR3 through EPRI assistance, some of the specific knowledge gaps that study of these cable materials can be used to address, and experimental plans for addressing those gaps using these materials. Harvested cables from CR3 and other NPPs that have experienced long term service, new old stock cables (manufactured before 2000, but never put in service), and relevant modern nuclear cables and materials from cable manufacturers are enabling research to address identified knowledge gaps and better understand long term aging behavior for cable materials currently installed in NPPs. This research, combined with refined understanding of actual service environments and conditions, will both support subsequent licensing activities and more efficient plant cable aging management.« less

  1. Cable load sensing device

    DOEpatents

    Beus, Michael J.; McCoy, William G.

    1998-01-01

    Apparatus for sensing the magnitude of a load on a cable as the cable is employed to support the load includes a beam structure clamped to the cable so that a length of the cable lies along the beam structure. A spacer associated with the beam structure forces a slight curvature in a portion of the length of cable under a cable "no-load" condition so that the portion of the length of cable is spaced from the beam structure to define a cable curved portion. A strain gauge circuit including strain gauges is secured to the beam structure by welding. As the cable is employed to support a load the load causes the cable curved portion to exert a force normal to the cable through the spacer and on the beam structure to deform the beam structure as the cable curved portion attempts to straighten under the load. As this deformation takes place, the resistance of the strain gauges is set to a value proportional to the magnitude of the normal strain on the beam structure during such deformation. The magnitude of the normal strain is manipulated in a control device to generate a value equal to the magnitude or weight of the load supported by the cable.

  2. 76 FR 71601 - Record of Decision, Long Walk National Historic Trail Feasibility Study/Abbreviated Final...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-18

    ... National Historic Trail Feasibility Study/Abbreviated Final Environmental Impact Statement, National Trails... Decision on the Abbreviated Final Environmental Impact Statement for the Long Walk National Historic Trail... Final Environmental Impact Statement for the Long Walk National Historic Trail Feasibility Study...

  3. Skeletal muscle cells express ICAM-1 after muscle overload and ICAM-1 contributes to the ensuing hypertrophic response.

    PubMed

    Dearth, Christopher L; Goh, Qingnian; Marino, Joseph S; Cicinelli, Peter A; Torres-Palsa, Maria J; Pierre, Philippe; Worth, Randall G; Pizza, Francis X

    2013-01-01

    We previously reported that leukocyte specific β2 integrins contribute to hypertrophy after muscle overload in mice. Because intercellular adhesion molecule-1 (ICAM-1) is an important ligand for β2 integrins, we examined ICAM-1 expression by murine skeletal muscle cells after muscle overload and its contribution to the ensuing hypertrophic response. Myofibers in control muscles of wild type mice and cultures of skeletal muscle cells (primary and C2C12) did not express ICAM-1. Overload of wild type plantaris muscles caused myofibers and satellite cells/myoblasts to express ICAM-1. Increased expression of ICAM-1 after muscle overload occurred via a β2 integrin independent mechanism as indicated by similar gene and protein expression of ICAM-1 between wild type and β2 integrin deficient (CD18-/-) mice. ICAM-1 contributed to muscle hypertrophy as demonstrated by greater (p<0.05) overload-induced elevations in muscle protein synthesis, mass, total protein, and myofiber size in wild type compared to ICAM-1-/- mice. Furthermore, expression of ICAM-1 altered (p<0.05) the temporal pattern of Pax7 expression, a marker of satellite cells/myoblasts, and regenerating myofiber formation in overloaded muscles. In conclusion, ICAM-1 expression by myofibers and satellite cells/myoblasts after muscle overload could serve as a mechanism by which ICAM-1 promotes hypertrophy by providing a means for cell-to-cell communication with β2 integrin expressing myeloid cells.

  4. Urotensin II inhibited the proliferation of cardiac side population cells in mice during pressure overload by JNK-LRP6 signalling

    PubMed Central

    Chen, Zhidan; Xu, Jiahong; Ye, Yong; Li, Yang; Gong, Hui; Zhang, Guoping; Wu, Jian; jia, Jianguo; Liu, Ming; Chen, Ying; Yang, Chunjie; Tang, Yu; Zhu, Yichun; Ge, Junbo; Zou, Yunzeng

    2014-01-01

    Cardiac side population cells (CSPs) are promising cell resource for the regeneration in diseased heart as intrinsic cardiac stem cells. However, the relative low ratio of CSPs in the heart limited the ability of CSPs to repair heart and improve cardiac function effectively under pathophysiological condition. Which factors limiting the proliferation of CSPs in diseased heart are unclear. Here, we show that urotensin II (UII) regulates the proliferation of CSPs by c-Jun N-terminal kinase (JNK) and low density lipoprotein receptor-related protein 6 (LRP6) signalling during pressure overload. Pressure overload greatly upregulated UII level in plasma, UII receptor (UT) antagonist, urantide, promoted CSPs proliferation and improved cardiac dysfunction during chronic pressure overload. In cultured CSPs subjected to mechanical stretch (MS), UII significantly inhibited the proliferation by UT. Nanofluidic proteomic immunoassay showed that it is the JNK activation, but not the extracellular signal-regulated kinase signalling, that involved in the UII-inhibited- proliferation of CSPs during pressure overload. Further analysis in vitro indicated UII-induced-phospho-JNK regulates phosphorylation of LRP6 in cultured CSPs after MS, which is important in the inhibitory effect of UII on the CSPs during pressure overload. In conclusion, UII inhibited the proliferation of CSPs by JNK/LRP6 signalling during pressure overload. Pharmacological inhibition of UII promotes CSPs proliferation in mice, offering a possible therapeutic approach for cardiac failure induced by pressure overload. PMID:24447593

  5. Skeletal Muscle Cells Express ICAM-1 after Muscle Overload and ICAM-1 Contributes to the Ensuing Hypertrophic Response

    PubMed Central

    Dearth, Christopher L.; Goh, Qingnian; Marino, Joseph S.; Cicinelli, Peter A.; Torres-Palsa, Maria J.; Pierre, Philippe; Worth, Randall G.; Pizza, Francis X.

    2013-01-01

    We previously reported that leukocyte specific β2 integrins contribute to hypertrophy after muscle overload in mice. Because intercellular adhesion molecule-1 (ICAM-1) is an important ligand for β2 integrins, we examined ICAM-1 expression by murine skeletal muscle cells after muscle overload and its contribution to the ensuing hypertrophic response. Myofibers in control muscles of wild type mice and cultures of skeletal muscle cells (primary and C2C12) did not express ICAM-1. Overload of wild type plantaris muscles caused myofibers and satellite cells/myoblasts to express ICAM-1. Increased expression of ICAM-1 after muscle overload occurred via a β2 integrin independent mechanism as indicated by similar gene and protein expression of ICAM-1 between wild type and β2 integrin deficient (CD18-/-) mice. ICAM-1 contributed to muscle hypertrophy as demonstrated by greater (p<0.05) overload-induced elevations in muscle protein synthesis, mass, total protein, and myofiber size in wild type compared to ICAM-1-/- mice. Furthermore, expression of ICAM-1 altered (p<0.05) the temporal pattern of Pax7 expression, a marker of satellite cells/myoblasts, and regenerating myofiber formation in overloaded muscles. In conclusion, ICAM-1 expression by myofibers and satellite cells/myoblasts after muscle overload could serve as a mechanism by which ICAM-1 promotes hypertrophy by providing a means for cell-to-cell communication with β2 integrin expressing myeloid cells. PMID:23505517

  6. Snails and their trails: the multiple functions of trail-following in gastropods.

    PubMed

    Ng, Terence P T; Saltin, Sara H; Davies, Mark S; Johannesson, Kerstin; Stafford, Richard; Williams, Gray A

    2013-08-01

    Snails are highly unusual among multicellular animals in that they move on a layer of costly mucus, leaving behind a trail that can be followed and utilized for various purposes by themselves or by other animals. Here we review more than 40 years of experimental and theoretical research to try to understand the ecological and evolutionary rationales for trail-following in gastropods. Data from over 30 genera are currently available, representing a broad taxonomic range living in both aquatic and terrestrial environments. The emerging picture is that the production of mucus trails, which initially was an adaptation to facilitate locomotion and/or habitat extension, has evolved to facilitate a multitude of additional functions. Trail-following supports homing behaviours, and provides simple mechanisms for self-organisation in groups of snails, promoting aggregation and thus relieving desiccation and predation pressures. In gastropods that copulate, trail-following is an important component in mate-searching, either as an alternative, or in addition to the release of water- or air-borne pheromones. In some species, this includes a capacity of males not only to identify trails of conspecifics but also to discriminate between trails laid by females and males. Notably, trail discrimination seems important as a pre-zygotic barrier to mating in some snail species. As production of a mucus trail is the most costly component of snail locomotion, it is also tempting to speculate that evolution has given rise to various ways to compensate for energy losses. Some snails, for example, increase energy intake by eating particles attached to the mucus of trails that they follow, whereas others save energy through reducing the production of their own mucus by moving over previously laid mucus trails. Trail-following to locate a prey item or a mate is also a way to save energy. While the rationale for trail-following in many cases appears clear, the basic mechanisms of trail discrimination, including the mechanisms by which many snails determine the polarity of the trail, are yet to be experimentally determined. Given the multiple functions of trail-following we propose that future studies should adopt an integrated approach, taking into account the possibility of the simultaneous occurrence of many selectively advantageous roles of trail-following behaviour in gastropods. We also believe that future opportunities to link phenotypic and genotypic traits will make possible a new generation of research projects in which gastropod trail-following, its multitude of functions and evolutionary trade-offs can be further elucidated. © 2013 The Authors. Biological Reviews © 2013 Cambridge Philosophical Society.

  7. Braided tubular superelastic cables provide improved spinal stability compared to multifilament sublaminar cables.

    PubMed

    Tremblay, Jaëlle; Mac-Thiong, Jean-Marc; Brailovski, Vladimir; Petit, Yvan

    2015-09-01

    This study investigates the use of braided tubular superelastic cables, previously used for sternum closure following sternotomy, as sublaminar fixation method. It compares the biomechanical performance of spinal instrumentation fixation systems with regular sublaminar cables and proprietary superelastic cables. A hybrid experimental protocol was applied to six porcine L1-L4 spinal segments to compare multifilament sublaminar cables (Atlas, Medtronic Sofamor Danek, Memphis, TN) with proprietary superelastic cables. First, intact total range of motion was determined for all specimens using pure moment loading. Second, pure moments were imposed to the instrumented specimens until these intact total ranges of motion were reproduced. Compared to the intact specimens, the use of superelastic cables resulted in stiffer instrumented specimens than the use of multifilament cables for all the loading modes except axial torsion. Consequently, the superelastic cables limited the instrumented segments mobility more than the multifilament cables. Spinal instrumentation fixation systems using superelastic cables could be a good alternative to conventional sublaminar cables as it maintains a constant stabilization of the spine during loading. © IMechE 2015.

  8. System for stabilizing cable phase delay utilizing a coaxial cable under pressure

    NASA Technical Reports Server (NTRS)

    Clements, P. A. (Inventor)

    1974-01-01

    Stabilizing the phase delay of signals passing through a pressurizable coaxial cable is disclosed. Signals from an appropriate source at a selected frequency, e.g., 100 MHz, are sent through the controlled cable from a first cable end to a second cable end which, electrically, is open or heavily mismatched at 100 MHz, thereby reflecting 100 MHz signals back to the first cable end. Thereat, the phase difference between the reflected-back signals and the signals from the source is detected by a phase detector. The output of the latter is used to control the flow of gas to or from the cable, thereby controlling the cable pressure, which in turn affects the cable phase delay.

  9. Fire related hazards of cables: The Canadian position development of fire resistant inside wiring cable

    NASA Astrophysics Data System (ADS)

    Hartley, M. D.; Jaques, R. E.

    1986-11-01

    The Canadian Electrical Code and the National Building Code in Canada recognize only two designations in regards to fire resistance of cables; cables for use in combustible (residential) buildings and cables for use in non-combustible buildings. The Test standard for cables for non-combustible buildings resembles IEEE-383. However, it is more severe; particularly for small nonarmoured cables such as Inside Wiring Cable. This forthcoming requirement has necessitated material and product development. Although an Inside Wiring cable modification of both insulation and jacket was undertaken, the large volume fraction of combustible material in the jacket vis a vis the insulation made it the area of greatest impact. The paper outlines the development and its effect on cable performance.

  10. 76 FR 35468 - Star-Spangled Banner National Historic Trail Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-17

    ... DEPARTMENT OF THE INTERIOR National Park Service Star-Spangled Banner National Historic Trail... the Advisory Committee on the Star-Spangled Banner National Historic Trail will hold a meeting. Designated through an amendment to the National Trails System Act (16 U.S.C. 1241), the trail consists of...

  11. 75 FR 29359 - Draft Environmental Impact Statement for the Tamiami Trail Modifications: Next Steps Project...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-25

    ... Tamiami Trail Modifications: Next Steps Project, Everglades National Park Tamiami Trail Modifications... Interior. ACTION: Notice of availability of the Draft Environmental Impact Statement for the Tamiami Trail... Statement (DEIS) for the Tamiami Trail (U.S. Highway 41) Modifications: Next Steps Project for Everglades...

  12. 75 FR 12254 - Official Trail Marker for the Ala Kahakai National Historic Trail

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-15

    ... DEPARTMENT OF THE INTERIOR National Park Service Official Trail Marker for the Ala Kahakai National Historic Trail AGENCY: National Park Service, Interior. ACTION: Official Insignia, Designation. Authority: National Trails System Act, 16 U.S.C. 1241(a) and l246(c) and Protection of Official Badges...

  13. 36 CFR 212.56 - Identification of designated roads, trails, and areas.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... roads, trails, and areas. 212.56 Section 212.56 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE TRAVEL MANAGEMENT Designation of Roads, Trails, and Areas for Motor Vehicle Use § 212.56 Identification of designated roads, trails, and areas. Designated roads, trails, and areas...

  14. 75 FR 37463 - Official Trail Marker for the Star-Spangled Banner National Historic Trail

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    ... DEPARTMENT OF THE INTERIOR National Park Service Official Trail Marker for the Star-Spangled Banner National Historic Trail AGENCY: National Parks Service, Interior. ACTION: Official Insignia, Designation. Authority: National Trails System Act, 16 U.S.C. 124(a) and 1246(c) and Protection of Official...

  15. Chemical communication in the dacetine antDaceton armigerum (Hymenoptera: Formicidae).

    PubMed

    Hölldobler, B; Palmer, J M; Moffett, M W

    1990-04-01

    Contrary to previous assumptions,Daceton armigerum, the largest ant in the myrmicine tribe Dacetini, employs trail communication. We identified two anatomical sources of trail pheromones: Trails drawn with poison gland contents can last for more than seven days. Trails drawn with the newly discovered sternal glands (in the VIth and VIIth abdominal sternites) are effective but relatively short-lived. In addition, our bioassays revealed that the contents of the mandibular glands elicit alarm behavior, and secretions from the pygidial gland release attraction. When tested with artificial poison gland trails from seven other myrmicine species,Daceton did not exhibit trail following behavior. We confirmed, however, previous findings thatAtta respond toDaceton poison gland trails andSolenopsis followDaceton Dufour's gland trails.

  16. The Effect of Nozzle Trailing Edge Thickness on Jet Noise

    NASA Technical Reports Server (NTRS)

    Henderson, Brenda; Kinzie, Kevin; Haskin, Henry

    2004-01-01

    The effect of nozzle trailing edge thickness on broadband acoustic radiation and the production of tones is investigated for coannular nozzles. Experiments were performed for a core nozzle trailing edge thickness between 0.38 mm and 3.17 mm. The on-set of discrete tones was found to be predominantly affected by the velocity ratio, the ratio of the fan velocity to the core velocity, although some dependency on trailing edge thickness was also noted. For a core nozzle trailing edge thickness greater than or equal to 0.89 mm, tones were produced for velocity ratios between 0.91 and 1.61. For a constant nozzle trailing edge thickness, the frequency varied almost linearly with the core velocity. The Strouhal number based on the core velocity changed with nozzle trailing edge thickness and varied between 0.16 and 0.2 for the core nozzles used in the experiments. Increases in broadband noise with increasing trailing edge thickness were observed for tone producing and non-tone producing conditions. A variable thickness trailing edge (crenellated) nozzle resulted in no tonal production and a reduction of the broadband trailing edge noise relative to that of the corresponding constant thickness trailing edge.

  17. Travel to, and use of, twenty-one Michigan trails.

    PubMed

    Price, Anna E; Reed, Julian A; Grost, Lisa; Harvey, Christina; Mantinan, Karah

    2013-03-01

    This study examined trail use among 857 trail users on 21 trails in Michigan from 2008 to 2011 using a valid and reliable intercept survey. Most of the 857 participants traveled to the trail from their home (92.6%), lived within 15 min of the trails (74.8%), and used active transport to travel to the trails 69.7%. The odds of active transport to the trails were greater among those who had not graduated high school (OR=3.49; 95% CI=1.02, 11.99) and high school graduates (OR=7.432; 95% CI=2.02, 27.30) compared to college graduates. Whites and adults also had greater odds of active transport than non-Whites (OR=3.160, 95% CI: 1.65, 6.05), and older adults (OR=1.75; 95% CI: 1.20, 2.54). The majority of respondents (89.7%) reported using trails for recreational purposes. A significantly greater proportion of females (73.3%) compared to males (64.7%) reported using the trail with others. The findings from this study might enable health and parks and recreation professionals to better promote physical activity on trails. Copyright © 2013 Elsevier Inc. All rights reserved.

  18. Hexyl decanoate, the first trail pheromone compound identified in a stingless bee, Trigona recursa.

    PubMed

    Jarau, Stefan; Schulz, Claudia M; Hrncir, Michael; Francke, Wittko; Zucchi, Ronaldo; Barth, Friedrich G; Ayasse, Manfred

    2006-07-01

    Foragers of many species of stingless bees guide their nestmates to food sources by means of scent trails deposited on solid substrates between the food and the nest. The corresponding trail pheromones are generally believed to be produced in the mandibular glands, although definitive experimental proof has never been provided. We tested the trail following behavior of recruits of Trigona recursa in field experiments with artificial scent trails branching off from natural scent trails of this stingless bee. First-time recruits (newcomers) did not follow these trails when they were laid with pure solvent or mandibular gland extract. However, they did follow trails made with labial gland extract. Chemical analyses of labial gland secretions revealed that hexyl decanoate was the dominant component (72.4 +/- 1.9% of all volatiles). Newcomers were significantly attracted to artificial trails made with synthetic hexyl decanoate, demonstrating its key function in eliciting scent-following behavior. According to our experiments with T. recursa, the trail pheromone is produced in the labial glands and not in the mandibular glands. Hexyl decanoate is the first component of a trail pheromone identified and proved to be behaviorally active in stingless bees.

  19. Stingless bees (Scaptotrigona pectoralis) learn foreign trail pheromones and use them to find food.

    PubMed

    Reichle, Christian; Aguilar, Ingrid; Ayasse, Manfred; Jarau, Stefan

    2011-03-01

    Foragers of several species of stingless bees (Hymenoptera, Apidae and Meliponini) deposit pheromone marks in the vegetation to guide nestmates to new food sources. These pheromones are produced in the labial glands and are nest and species specific. Thus, an important question is how recruited foragers recognize their nestmates' pheromone in the field. We tested whether naïve workers learn a specific trail pheromone composition while being recruited by nestmates inside the hive in the species Scaptotrigona pectoralis. We installed artificial scent trails branching off from trails deposited by recruiting foragers and registered whether newly recruited bees follow these trails. The artificial trails were baited with trail pheromones of workers collected from foreign S. pectoralis colonies. When the same foreign trail pheromone was presented inside the experimental hives while recruitment took place a significant higher number of bees followed the artificial trails than in experiments without intranidal presentation. Our results demonstrate that recruits of S. pectoralis can learn the composition of specific trail pheromone bouquets inside the nest and subsequently follow this pheromone in the field. We, therefore, suggest that trail pheromone recognition in S. pectoralis is based on a flexible learning process rather than being a genetically fixed behaviour.

  20. The beneficial pleiotropic effects of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) within the vasculature: A review of the evidence.

    PubMed

    Forde, Hannah; Harper, Emma; Davenport, Colin; Rochfort, Keith D; Wallace, Robert; Murphy, Ronan P; Smith, Diarmuid; Cummins, Philip M

    2016-04-01

    Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein that belongs to the tumour necrosis factor (TNF) cytokine superfamily. TRAIL is expressed by numerous cell types including vascular cells, immune cells and adipocytes. Although originally thought to induce apoptosis in malignant or transformed cells only, it is now known that TRAIL can bind up to 5 distinct receptors to activate complex signalling pathways, and is capable of exerting pleiotropic effects in non-transformed cells. In this respect, a number of clinical and animal studies point to the potential vasoprotective influence of TRAIL, with TRAIL deficiency being linked to accelerated atherosclerosis and vascular calcification. Moreover, exogenous TRAIL administration has been shown to exhibit anti-atherosclerotic activity in-vivo. In-vitro studies on TRAIL in this context have yielded conflicting results however, with evidence of both pro-atherogenic and vasoprotective effects ascribed to TRAIL. Notwithstanding these various studies, mechanistic information on the precise nature of TRAIL-mediated injury/protection within the vasculature, as well as the identity of the downstream molecular/cellular targets of TRAIL, is still quite limited. In this review, we will summarize our current knowledge of TRAIL regulation, signalling mechanisms, and its apparent involvement in CVD pathogenesis as a prelude to examining the existing evidence for TRAIL-mediated vasoprotection. To this end, extensive in vitro, in vivo, and clinical studies will be reviewed and critical findings highlighted. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  1. Role of trail pheromone in foraging and processionary behavior of pine processionary caterpillars Thaumetopoea pityocampa.

    PubMed

    Fitzgerald, T D

    2003-03-01

    Although caterpillars of Thaumetopoea pityocamnpa may mark their pathways with silk, this study shows that the material is essential to neither the elicitation nor maintenance of trail-following or processionary behavior. Trail following is dependent upon a pheromone the caterpillars deposit by brushing the ventral surfaces of the tips of their abdomens against the substate. Earlier instars are strongly bound to their trail system; in the laboratory, caterpillars followed circular trails continuously for as long as 12 hr before breaking away from them. The trail pheromone is long-lived and soluble in nonpolar solvents, but its volatilization or degradation allows the caterpillars to distinguish new from aged trails. In contrast to trail following, processionary behavior, the head-to-tail, single-file movement of the caterpillars is dependent on neither silk nor the trail pheromone. Stimuli associated with setae found on the tip of the abdomen of the precedent caterpillar serve to hold processions together, and such stimuli take priority over those associated with either the trail pheromone or silk. Although the caterpillars discern trail strength and choose stronger over weaker trails, the trail marking system of the processionary caterpillar appears less sophisticated than those of other, previously studied species of social caterpillars, and colonies are relatively inefficient in abandoning exhausted feeding sites in favor of new food finds. In laboratory studies, females were more likely to lead processions than males, and leaders, regardless of gender, expended more energy in locomotion than followers.

  2. Promoting and developing a trail network across suburban, rural, and urban communities.

    PubMed

    Schasberger, Michele G; Hussa, Carol S; Polgar, Michael F; McMonagle, Julie A; Burke, Sharon J; Gegaris, Andrew J

    2009-12-01

    The Wyoming Valley Wellness Trails Partnership received an Active Living by Design grant late in 2003 for a project centered on a growing trail network linking urban, suburban, and rural communities in northeast Pennsylvania, a former coal region, in order to increase physical activity among residents. The partnership conducted research, collected information, created promotional documents, worked with partners on events and programs, and participated in trail planning. Local trail organizations continued planning and construction toward developing a trail network. Other partners spearheaded policy change in schools and worksites and worked toward downtown revitalization. The partnership assisted these efforts by providing a forum in which organizations could meet. The partnership became a central resource for information about local parks, trails, and outdoor recreational activities. The partnership increased awareness and use of recreational facilities. Trail partners constructed 22 miles of walking and biking trails. The partnership took advantage of an allied effort that created organizational capacity for wellness in schools and worksites. Messages promoting social and entertainment benefits of physical activity were more successful than those promoting health benefits. The existence of multiple small, independent trail organizations can help advance trail development through concurrent development efforts. Urban, suburban, and rural residents' conceptions of walkability may differ. Trails provide options for recreational and transportation-related physical activity across urban, suburban, and rural landscapes that are supported by all constituents. Trail builders can be strong allies in bringing active living to suburban and rural places.

  3. Triptolide enhances the tumoricidal activity of TRAIL against renal cell carcinoma.

    PubMed

    Brincks, Erik L; Kucaba, Tamara A; James, Britnie R; Murphy, Katherine A; Schwertfeger, Kathryn L; Sangwan, Veena; Banerjee, Sulagna; Saluja, Ashok K; Griffith, Thomas S

    2015-12-01

    Renal cell carcinoma (RCC) is resistant to traditional cancer therapies, and metastatic RCC (mRCC) is incurable. The shortcomings in current therapeutic options for patients with mRCC provide the rationale for the development of novel treatment protocols. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has proven to be a potent inducer of tumor cell death in vitro and in vivo, and a number of TRAIL death receptor agonists (recombinant TRAIL or TRAIL death receptor-specific mAb) have been developed and tested clinically. Unfortunately the clinical efficacy of TRAIL has been underwhelming and is likely due to a number of possible mechanisms that render tumors resistant to TRAIL, prompting the search for drugs that increase tumor cell susceptibility to TRAIL. The objective of this study was to determine the effectiveness of combining the diterpene triepoxide triptolide, or its water-soluble prodrug, Minnelide, with TRAIL receptor agonists against RCC in vitro or in vivo, respectively. TRAIL-induced apoptotic death of human RCC cells was increased in the presence of triptolide. The triptolide-induced sensitization was accompanied by increased TRAIL-R2 (DR5) and decreased heat shock protein 70 expression. In vivo treatment of mice bearing orthotopic RCC (Renca) tumors showed the combination of Minnelide and agonistic anti-DR5 mAb significantly decreased tumor burden and increased animal survival compared to either therapy alone. Our data suggest triptolide/Minnelide sensitizes RCC cells to TRAIL-induced apoptosis through altered TRAIL death receptor and heat shock protein expression. © 2015 FEBS.

  4. Triptolide Enhances the Tumoricidal Activity of TRAIL Against Renal Cell Carcinoma

    PubMed Central

    James, Britnie R.; Murphy, Katherine A.; Schwertfeger, Kathryn L.; Sangwan, Veena; Banerjee, Sulagna; Saluja, Ashok K.; Griffith, Thomas S.

    2015-01-01

    Renal cell carcinoma (RCC) is resistant to traditional cancer therapies, and metastatic RCC (mRCC) is incurable. The shortcomings in current therapeutic options for patients with mRCC provide the rationale for the development of novel treatment protocols. TNF-related apoptosis-inducing ligand (TRAIL) has proven to be a potent inducer of tumor cell death in vitro and in vivo, and a number of TRAIL death receptor agonists (recombinant TRAIL or TRAIL death receptor-specific mAb) has been developed and tested clinically. Unfortunately the clinical efficacy of TRAIL has been underwhelming and is likely due to a number of possible mechanisms that render tumors resistant to TRAIL, prompting the search for drugs that increase tumor cell susceptibility to TRAIL. The objective of this study was to determine the effectiveness of combining the diterpene triepoxide triptolide, or its water-soluble prodrug, Minnelide, with TRAIL receptor agonists against RCC in vitro or in vivo, respectively. TRAIL-induced apoptotic death of human RCC cells was increased in the presence of triptolide. The triptolide-induced sensitization was accompanied by increased TRAIL-R2 (DR5) and decreased HSP70 expression. In vivo treatment of mice bearing orthotopic RCC (Renca) tumors showed the combination of Minnelide and agonistic anti-DR5 mAb significantly decreased tumor burden and increased animal survival compared to either therapy alone. Our data suggest triptolide/Minnelide sensitizes RCC cells to TRAIL-induced apoptosis through altered TRAIL death receptor and heat shock protein expression. PMID:26426449

  5. Selective inhibition of FLICE-like inhibitory protein expression with small interfering RNA oligonucleotides is sufficient to sensitize tumor cells for TRAIL-induced apoptosis.

    PubMed Central

    Siegmund, Daniela; Hadwiger, Philipp; Pfizenmaier, Klaus; Vornlocher, Hans-Peter; Wajant, Harald

    2002-01-01

    BACKGROUND: Most tumors express death receptors and their activation represents a potential selective approach in cancer treatment. The most promising candidate for tumor selective death receptor-activation is tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo2L, which activates the death receptors TRAIL-R1 and TRAIL-R2, and induces apoptosis preferentially in tumor cells but not in normal tissues. However, many cancer cells are not or only moderately sensitive towards TRAIL and require cotreatment with irradiation or chemotherapy to yield a therapeutically reasonable apoptotic response. Because chemotherapy can have a broad range of unwanted side effects, more specific means for sensitizing tumor cells for TRAIL are desirable. The expression of the cellular FLICE-like inhibitory protein (cFLIP) is regarded as a major cause of TRAIL resistance. We therefore analyzed the usefulness of targeting FLIP to sensitize tumor cells for TRAIL-induced apoptosis. MATERIALS AND METHODS: To selectively interfere with expression of cFLIP short double-stranded RNA oligonucleotides (small interfering RNAs [siRNAs]) were introduced in the human cell lines SV80 and KB by electroporation. Effects of siRNA on FLIP expression were analyzed by Western blotting and RNase protection assay and correlated with TRAIL sensitivity upon stimulation with recombinant soluble TRAIL and TRAIL-R1- and TRAIL-R2-specific agonistic antibodies. RESULTS: FLIP expression can be inhibited by RNA interference using siRNAs, evident from reduced levels of FLIP-mRNA and FLIP protein. Inhibition of cFLIP expression sensitizes cells for apoptosis induction by TRAIL and other death ligands. In accordance with the presumed function of FLIP as an inhibitor of death receptor-induced caspase-8 activation, down-regulation of FLIP by siRNAs enhanced TRAIL-induced caspase-8 activation. CONCLUSION: Inhibition of FLIP expression was sufficient to sensitize tumor cells for TRAIL-induced apoptosis. The combination of TRAIL and FLIP-targeting siRNA could therefore be a useful strategy to attack cancer cells, which are resistant to TRAIL alone. PMID:12520089

  6. Modal resonant dynamics of cables with a flexible support: A modulated diffraction problem

    NASA Astrophysics Data System (ADS)

    Guo, Tieding; Kang, Houjun; Wang, Lianhua; Liu, Qijian; Zhao, Yueyu

    2018-06-01

    Modal resonant dynamics of cables with a flexible support is defined as a modulated (wave) diffraction problem, and investigated by asymptotic expansions of the cable-support coupled system. The support-cable mass ratio, which is usually very large, turns out to be the key parameter for characterizing cable-support dynamic interactions. By treating the mass ratio's inverse as a small perturbation parameter and scaling the cable tension properly, both cable's modal resonant dynamics and the flexible support dynamics are asymptotically reduced by using multiple scale expansions, leading finally to a reduced cable-support coupled model (i.e., on a slow time scale). After numerical validations of the reduced coupled model, cable-support coupled responses and the flexible support induced coupling effects on the cable, are both fully investigated, based upon the reduced model. More explicitly, the dynamic effects on the cable's nonlinear frequency and force responses, caused by the support-cable mass ratio, the resonant detuning parameter and the support damping, are carefully evaluated.

  7. 105. VIEW NORTH FROM SLC3W CABLE TUNNEL INTO CABLE VAULT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    105. VIEW NORTH FROM SLC-3W CABLE TUNNEL INTO CABLE VAULT AND SLC-3E CABLE TUNNEL. NOTE WOODEN PLANKING ON FLOOR OF TUNNEL AND CABLE TRAYS LINING TUNNEL WALLS. STAIRS ON EAST WALL OF CABLE VAULT LEAD INTO LANDLINE INSTRUMENTATION ROOM. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Operations Building, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

  8. Frequency domain reflectometry NDE for aging cables in nuclear power plants

    NASA Astrophysics Data System (ADS)

    Glass, S. W.; Jones, A. M.; Fifield, L. S.; Hartman, T. S.

    2017-02-01

    Degradation of the cable jacket, electrical insulation, and other cable components of installed cables within nuclear power plants (NPPs) is known to occur as a function of age, temperature, radiation, and other environmental factors. Although system tests verify cable function under normal loads, demonstration of some cable's ability to perform under exceptional loads associated with design-basis events is essential to assuring plant integrity. The cable's ability to perform safely over the initial 40-year planned and licensed life has generally been demonstrated and there have been very few age-related cable failures. With greater than 1000 km of power, control, instrumentation, and other cables typically found in an NPP, replacing all the cables would be a severe cost burden. Justification for life extension to 60 and 80 years requires a cable aging management program that includes condition monitoring to justify cable performance under normal operation as well as accident conditions. A variety of tests are available to assess various aspects of electrical and mechanical cable performance, but none are suitable for all cable configurations nor does any single test confirm all features of interest. One particularly promising test that is beginning to be used more and more by utilities is frequency domain reflectometry (FDR). FDR is a nondestructive electrical inspection technique used to detect and localize faults in power and communication system conductors along the length of a cable from a single connection point. FDR detects discontinuities in the electrical impedance that arise due to cable splices or similar changes along the path of the conductor pair. In addition, FDR has the potential to provide sensitivity to insulation degradation by detecting small changes in impedance between the cable conductors being examined. The technique is also sensitive to cable bends, the particular lay of the cable in tray, proximity to other cable, and other factors that bear consideration when interpreting the test results. This paper examines various influences on the FDR approach and compares results of three different instruments to assess accelerated aging damage among several NPP representative cables.

  9. The Cables Gene on Chromosome 18q Is Silenced by Promoter Hypermethylation and Allelic Loss in Human Colorectal Cancer

    PubMed Central

    Park, Do Youn; Sakamoto, Hideo; Kirley, Sandra D.; Ogino, Shuji; Kawasaki, Takako; Kwon, Eunjeong; Mino-Kenudson, Mari; Lauwers, Gregory Y.; Chung, Daniel C.; Rueda, Bo R.; Zukerberg, Lawrence R.

    2007-01-01

    Cables is a cyclin-dependent kinase-binding nuclear protein that maps to chromosome 18q11-12. Here, we assessed Cables expression in 160 colorectal cancers (CRCs), its role in colon cancer cell growth, and the potential mechanisms of Cables inactivation. Expression levels, promoter methylation, and mutational status of Cables were investigated in colon cancer cell lines and primary colon tumors. Chromosome 18q loss of heterozygosity (LOH) was evaluated with multiple polymorphic markers. Cables inhibited cellular proliferation and colony formation in colon cancer cell lines. Cables expression was reduced in 65% of primary CRCs. No mutations were detected in 10 exons of Cables in 20 primary colon tumors. Cables promoter was methylated in cell lines with decreased Cables expression and vice versa. 5-Aza-2′-deoxycytidine resulted in increased Cables expression in methylated cell lines. There was a significant correlation between promoter methylation and Cables gene expression in primary colon tumors. Sixty-five percent of primary colon tumors demonstrated chromosome 18q LOH. LOH involving the Cables region was observed in 35% of cases, including those in which more distal portions of chromosome 18q were retained, and Cables expression was decreased in all such cases. Loss of Cables expression in 65% of CRCs suggests that it is a common event in colonic carcinogenesis, with promoter methylation and LOH appearing to be important mechanisms of Cables gene inactivation. PMID:17982127

  10. Investigation of cables for ionization chambers.

    PubMed

    Spokas, J J; Meeker, R D

    1980-01-01

    Seven coaxial cables which are in use for carrying currents generated in ionization chambers have been critically studied with reference to their suitability to this application. Included in this study are four low-noise triaxial cables and three low-noise two-conductor cables. For each cable the following characteristics were considered: inherent noise currents, currents produced by cable movements, polarization currents, the degree of electrostatic shielding of the central signal-carrying conductor, and radiation-induced cable currents. The study indicated that of the seven cables, two low-noise triaxial cables, both employing solid Teflon dielectric surrounding the central conductor, appear to offer the best overall performance for use with ionization chambers.

  11. An Internal Coaxial Cable Electrical Connector For Use In Downhole Tools

    DOEpatents

    Hall, David R.; Hall, Jr., H. Tracy; Pixton, David S.; Dahlgren, Scott; Fox, Joe; Sneddon, Cameron; Briscoe, Michael

    2005-11-29

    A coaxial cable electrical connector more specifically an internal coaxial cable connector placed within a coaxial cable and its constituent components. A coaxial cable connector is in electrical communcation with an inductive transformer and a coaxial cable. The connector is in electrical communication with the outer housing of the inductive transfonner. A generally coaxial center conductor, a portion of which could be the coil in the inductive transformer, passes through the connector, is electrically insulated from the connector, and is in electrical communication with the conductive care of the coaxial cable. A plurality of bulbous pliant tabs on the coaxial cable connector mechanically engage the inside diameter of the coaxial cable thus grounding the transformer to the coaxial cable. The coaxial cable and inductive transformer are disposed within downhole tools to transmit electrical signals between downhole tools within a drill string.

  12. High power cable with internal water cooling 400 kV

    NASA Astrophysics Data System (ADS)

    Rasquin, W.; Harjes, B.

    1982-08-01

    Due to the concentration of electricity production in large power plants, the need of higher power transmissions, and the protection of environment, developement of a 400 kV water cooled cable in the power range of 1 to 5 GVA was undertaken. The fabrication and testing of equipment, engineering of cable components, fabrication of a test cable, development of cable terminal laboratory, testing of test cable, field testing of test cable, fabrication of industrial cable laboratory, testing of industrial cable, field testing of industrial cable, and system analysis for optimization were prepared. The field testing was impossible to realize. However, it is proved that a cable consisting of an internal stainless steel water cooled tube, covered by stranded copper profiles, insulated with heavy high quality paper, and protected by an aluminum cover can be produced, withstand tests accordingly to IEC/VDE recommendations, and is able to fulfill all exploitation conditions.

  13. 30 CFR 7.403 - Application requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... APPROVAL OF MINING PRODUCTS TESTING BY APPLICANT OR THIRD PARTY Electric Cables, Signaling Cables, and Cable Splice Kits § 7.403 Application requirements. (a) Electric cables and signaling cables. A single... product: (1) Product information: (i) Cable type (for example, G or G-GC). (ii) Construction (for example...

  14. 30 CFR 7.403 - Application requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... APPROVAL OF MINING PRODUCTS TESTING BY APPLICANT OR THIRD PARTY Electric Cables, Signaling Cables, and Cable Splice Kits § 7.403 Application requirements. (a) Electric cables and signaling cables. A single... product: (1) Product information: (i) Cable type (for example, G or G-GC). (ii) Construction (for example...

  15. 30 CFR 7.403 - Application requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... APPROVAL OF MINING PRODUCTS TESTING BY APPLICANT OR THIRD PARTY Electric Cables, Signaling Cables, and Cable Splice Kits § 7.403 Application requirements. (a) Electric cables and signaling cables. A single... product: (1) Product information: (i) Cable type (for example, G or G-GC). (ii) Construction (for example...

  16. Effect of oxygen concentration on fire growth of various types of cable bending in horizontal and vertical orientations

    NASA Astrophysics Data System (ADS)

    Pangaribuan, Adrianus; Dhiputra, I. M. K.; Nugroho, Yulianto S.

    2017-03-01

    Electrical cable is a whole of the material including metal (cooper) conductor and its insulation, when an electrical cable is flowed by electric current, based on its own capacity, the temperature of cable conductor increases gradually. If the current flows above the cable carrying capacity, then an extreme temperature rises are expected. When temperature increase, the electric current flow inside cable conductor will decrease gradually related to the resistance and could occur repeatedly in a period. Since electrical faults on electrical cable system are often suspected as the cause of fires, thus this research aims to investigate measures of preventing the fire to start by means of controlling oxygen concentration in a cable compartment. The experimental work was conducted in laboratory by using electrical power cable of 1.5 mm2 size. Two transparent chambers were applied for studying the effect of vertical and horizontal orientations on the cable temperature rise, under various oxygen concentration of the gas streams. In the present work, the electrical was maintained at a constant level during a typical test run. Parametric studies reported in the paper include the use of a bare and insulated cables as well as the bending shape of the cable lines of a straight cable, coiled cable and randomly bent cable which were loaded with the same electric load and oxygen concentration in the gas supply.

  17. Environmental perceptions and objective walking trail audits inform a community-based participatory research walking intervention

    PubMed Central

    2012-01-01

    Background Given the documented physical activity disparities that exist among low-income minority communities and the increased focused on socio-ecological approaches to address physical inactivity, efforts aimed at understanding the built environment to support physical activity are needed. This community-based participatory research (CBPR) project investigates walking trails perceptions in a high minority southern community and objectively examines walking trails. The primary aim is to explore if perceived and objective audit variables predict meeting recommendations for walking and physical activity, MET/minutes/week of physical activity, and frequency of trail use. Methods A proportional sampling plan was used to survey community residents in this cross-sectional study. Previously validated instruments were pilot tested and appropriately adapted and included the short version of the validated International Physical Activity Questionnaire, trail use, and perceptions of walking trails. Walking trails were assessed using the valid and reliable Path Environmental Audit Tool which assesses four content areas including: design features, amenities, maintenance, and pedestrian safety from traffic. Analyses included Chi-square, one-way ANOVA's, multiple linear regression, and multiple logistic models. Results Numerous (n = 21) high quality walking trails were available. Across trails, there were very few indicators of incivilities and safety features rated relatively high. Among the 372 respondents, trail use significantly predicted meeting recommendations for walking and physical activity, and MET/minutes/week. While controlling for other variables, significant predictors of trail use included proximity to trails, as well as perceptions of walking trail safety, trail amenities, and neighborhood pedestrian safety. Furthermore, while controlling for education, gender, and income; for every one time per week increase in using walking trails, the odds for meeting walking recommendations increased 1.27 times, and the odds for meeting PA recommendation increased 3.54 times. Perceived and objective audit variables did not predict meeting physical activity recommendations. Conclusions To improve physical activity levels, intervention efforts are needed to maximize the use of existing trails, as well as improve residents' perceptions related to incivilities, safety, conditions of trail, and amenities of the walking trails. This study provides important insights for informing development of the CBPR walking intervention and informing local recreational and environmental policies in this southern community. PMID:22289653

  18. Learners' Perceived Information Overload in Online Learning via Computer-Mediated Communication

    ERIC Educational Resources Information Center

    Chen, Chun-Ying; Pedersen, Susan; Murphy, Karen L.

    2011-01-01

    Many studies report information overload as one of the main problems that students encounter in online learning via computer-mediated communication. This study aimed to explore the sources of online students' information overload and offer suggestions for increasing students' cognitive resources for learning. Participants were 12 graduate students…

  19. 30 CFR 75.518 - Electric equipment and circuits; overload and short circuit protection.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... short circuit protection. 75.518 Section 75.518 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION... Equipment-General § 75.518 Electric equipment and circuits; overload and short circuit protection... installed so as to protect all electric equipment and circuits against short circuit and overloads. Three...

  20. 30 CFR 77.506-1 - Electric equipment and circuits; overload and short circuit protection; minimum requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... short circuit protection; minimum requirements. 77.506-1 Section 77.506-1 Mineral Resources MINE SAFETY...-1 Electric equipment and circuits; overload and short circuit protection; minimum requirements. Devices providing either short circuit protection or protection against overload shall conform to the...

  1. Role Overload, Job Satisfaction, Leisure Satisfaction, and Psychological Health among Employed Women

    ERIC Educational Resources Information Center

    Pearson, Quinn M.

    2008-01-01

    Role overload, job satisfaction, leisure satisfaction, and psychological health were measured for 155 women who were employed full time. Role overload was negatively correlated with psychological health, job satisfaction, and leisure satisfaction. Job satisfaction and leisure satisfaction were positively correlated with psychological health.…

  2. Testosterone and muscle hypertrophy in female rats

    NASA Technical Reports Server (NTRS)

    Kuhn, F. E.; Max, S. R.

    1985-01-01

    The effects of chronic treatment with testosterone propionate (TP) on compensatory muscle hypertropy in female rats are examined. The 48 female rats were placed in one of four test groups: (1) no overload (synergist removal), no TP, (2) overload, no TP, (3) no overload + TP, and (4) overload + TP. The technique used to administer the TP is described. The preparation of the plantaris muscle, the analysis of pyruvate oxidation and the determination of malate and lactate dehydrogenases and the noncollogen protein are explained. The results which reveal the effect of overload and TP on body weight, noncollogen protein concentration, lactate and malate dehydrogenase activities, and pyruvate oxidation are presented and discussed. It is concluded that in terms of body weight, protein content, pyruvate, glycolysis, and oxidative metabolisms chronic TP treatments do not change compensatory muscle hypertropy.

  3. Autoimmune Hepatitis: Diagnostic Dilemma When It Is Disguised as Iron Overload Syndrome.

    PubMed

    Acharya, Gyanendra K; Liao, Hung-I; Frunza-Stefan, Simona; Patel, Ronakkumar; Khaing, Moe

    2017-09-01

    Elevated serum ferritin level is a common finding in iron overload syndrome, autoimmune and viral hepatitis, alcoholic and nonalcoholic fatty liver diseases. High transferrin saturation is not a common finding in above diseases except for iron overload syndrome. We encountered a challenging case of 73-year-old female who presented with yellowish discoloration of skin, dark color urine and dull abdominal pain. Initial laboratory tests reported mild anemia; elevated bilirubin, liver enzymes, and transferrin saturation. We came to the final diagnosis of autoimmune hepatitis after extensive workups. Autoimmune hepatitis is a rare disease, and the diagnosis can be further complicated by a similar presentation of iron overload syndrome. Markedly elevated transferrin saturation can simulate iron overload syndrome, but a liver biopsy can guide physicians to navigate the diagnosis.

  4. Qualitative job stress and ego aptitude in male scientific researchers.

    PubMed

    Sakagami, Yu

    2016-11-22

    Job environments have been fundamentally changed by globalization and modern technological innovation. Qualitative workload is expected to increase more than quantitative workload through this rapid technological innovation. Especially, in developed countries, qualitative workload is expected to become a primary job-related stress factor in the near future. Therefore, it is essential to clarify the characteristics of qualitative workload and to determine how to cope with it effectively. Since job stress level and ego aptitude are correlated and qualitative overload increases stress, we examined qualitative overload and ego aptitude among male Japanese cutting-edge science researchers. The Brief Job Stress Questionnaire and the Tokyo University Ego-gram New Version II were distributed to all workers at two Japanese academic institutions. Qualitative overload and adult ego aptitude, representing rationalism, were higher in male researchers than in the Japanese male general sample. In addition, adapted child aptitude, representing obedience, was lower in male researchers. Lack of supervisor support was positively associated with qualitative overload, and nurturing parent ego aptitude was negatively associated with it. Male researchers had higher levels of qualitative overload. Increasing supervisor support is essential in decreasing this qualitative overload. Furthermore, enhancement of nurturing parent ego aptitude (i.e., careful consideration for others) is also important for qualitative overload management.

  5. Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors.

    PubMed

    Fang, Shenglin; Yu, Xiaonan; Ding, Haoxuan; Han, Jianan; Feng, Jie

    2018-06-11

    Iron overload causes many diseases, while the underlying etiologies of these diseases are unclear. Cell death processes including apoptosis, necroptosis, cyclophilin D-(CypD)-dependent necrosis and a recently described additional form of regulated cell death called ferroptosis, are dependent on iron or iron-dependent reactive oxygen species (ROS). However, whether the accumulation of intracellular iron itself induces ferroptosis or other forms of cell death is largely elusive. In present study, we study the role of intracellular iron overload itself-induced cell death mechanisms by using ferric ammonium citrate (FAC) and a membrane-permeable Ferric 8-hydroxyquinoline complex (Fe-8HQ) respectively. We show that FAC-induced intracellular iron overload causes ferroptosis. We also identify 3-phosphoinositide-dependent kinase 1 (PDK1) inhibitor GSK2334470 as a potent ferroptosis inhibitor. Whereas, Fe-8HQ-induced intracellular iron overload causes unregulated necrosis, but partially activates PARP-1 dependent parthanatos. Interestingly, we identify many phenolic compounds as potent inhibitors of Fe-8HQ-induced cell death. In conclusion, intracellular iron overload-induced cell death form might be dependent on the intracellular iron accumulation rate, newly identified cell death inhibitors in our study that target ferroptosis and unregulated oxidative cell death represent potential therapeutic strategies against iron overload related diseases. Copyright © 2018 Elsevier Inc. All rights reserved.

  6. Comparing the impacts of hiking, skiing and horse riding on trail and vegetation in different types of forest.

    PubMed

    Törn, A; Tolvanen, A; Norokorpi, Y; Tervo, R; Siikamäki, P

    2009-03-01

    Nature-based tourism in protected areas has increased and diversified dramatically during the last decades. Different recreational activities have a range of impacts on natural environments. This paper reports results from a comparison of the impacts of hiking, cross-country skiing and horse riding on trail characteristics and vegetation in northern Finland. Widths and depths of existing trails, and vegetation on trails and in the neighbouring forests were monitored in two research sites during 2001 and 2002. Trail characteristics and vegetation were clearly related to the recreational activity, research site and forest type. Horse trails were as deep as hiking trails, even though the annual number of users was 150-fold higher on the hiking trails. Simultaneously, cross-country skiing had the least effect on trails due to the protective snow cover during winter. Hiking trail plots had little or no vegetation cover, horse riding trail plots had lower vegetation cover than forest plots, while skiing had no impact on total vegetation cover. On the other hand, on horse riding trails there were more forbs and grasses, many of which did not grow naturally in the forest. These species that were limited to riding trails may change the structure of adjacent plant communities in the long run. Therefore, the type of activities undertaken and the sensitivity of habitats to these activities should be a major consideration in the planning and management of nature-based tourism. Establishment of artificial structures, such as stairs, duckboards and trail cover, or complete closure of the site, may be the only way to protect the most sensitive or deteriorated sites.

  7. Assessing and Predicting Erosion from Off Highway Vehicle Trails in Front-Range Rocky Mountain Watersheds.

    NASA Astrophysics Data System (ADS)

    Howard, M. J.; Silins, U.; Anderson, A.

    2016-12-01

    Off highway vehicle (OHV) trails have the potential to deliver sediment to sensitive headwater streams and increased OHV use is a growing watershed management concern in many Rocky Mountain regions. Predictive tools for estimating erosion and sediment inputs are needed to support assessment and management of erosion from OHV trail networks. The objective of this study was to a) assess erodibility (K factor) and total erosion from OHV trail networks in Rocky Mountain watersheds in south-west Alberta, Canada, and to b) evaluate the applicability of the Universal Soil Loss Equation (USLE) for predicting OHV trail erosion to support erosion management strategies. Measured erosion rates and erodibility (K) from rainfall simulation plots on OHV trails during the summers of 2014 and 2015 were compared to USLE predicted erosion from these same trails. Measured erodibility (K) from 23 rainfall simulation plots was highly variable (0.001-0.273 Mg*ha*hr/ha*MJ*mm) as was total seasonal erosion from 52 large trail sections (0.0595-43.3 Mg/ha) across trail segments of variable slope, stoniness, and trail use intensity. In particular, intensity of trail use had a large effect on both erodibility and total erosion that is not presently captured by erodibility indices (K) derived from soil characteristics. Results of this study suggest that while application of USLE for predicting erosion from OHV trail networks may be useful for initial coarse erosion assessment, a better understanding of the effect of factors such as road/trail use intensity on erodibility is needed to support use of USLE or associated erosion prediction tools for road/trail erosion management.

  8. Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Signaling and Cell Death in the Immature Central Nervous System after Hypoxia-Ischemia and Inflammation*

    PubMed Central

    Kichev, Anton; Rousset, Catherine I.; Baburamani, Ana A.; Levison, Steven W.; Wood, Teresa L.; Gressens, Pierre; Thornton, Claire; Hagberg, Henrik

    2014-01-01

    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family. The interaction of TRAIL with death receptor 4 (DR4) and DR5 can trigger apoptotic cell death. The aim of this study was to investigate the role of TRAIL signaling in neonatal hypoxia-ischemia (HI). Using a neonatal mouse model of HI, mRNA, and protein expression of TRAIL, DR5 and the TRAIL decoy receptors osteoprotegerin (OPG), mDcTRAILR1, and mDcTRAILR2 were determined. In vitro, mRNA expression of these genes was measured in primary neurons and oligodendrocyte progenitor cells (OPCs) after inflammatory cytokine (TNF-α/IFN-γ) treatment and/or oxygen and glucose deprivation (OGD). The toxicity of these various paradigms was also measured. The expression of TRAIL, DR5, OPG, and mDcTRAILR2 was significantly increased after HI. In vitro, inflammatory cytokines and OGD treatment significantly induced mRNAs for TRAIL, DR5, OPG, and mDcTRAILR2 in primary neurons and of TRAIL and OPG in OPCs. TRAIL protein was expressed primarily in microglia and astroglia, whereas DR5 co-localized with neurons and OPCs in vivo. OGD enhanced TNF-α/IFN-γ toxicity in both neuronal and OPC cultures. Recombinant TRAIL exerted toxicity alone or in combination with OGD and TNF-α/IFN-γ in primary neurons but not in OPC cultures. The marked increases in the expression of TRAIL and its receptors after cytokine exposure and OGD in primary neurons and OPCs were similar to those found in our animal model of neonatal HI. The toxicity of TRAIL in primary neurons suggests that TRAIL signaling participates in neonatal brain injury after inflammation and HI. PMID:24509861

  9. Novel targets for sensitizing breast cancer cells to TRAIL-induced apoptosis with siRNA delivery.

    PubMed

    Thapa, Bindu; Bahadur Kc, Remant; Uludağ, Hasan

    2018-02-01

    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in variety of cancer cells without affecting most normal cells, which makes it a promising agent for cancer therapy. However, TRAIL therapy is clinically not effective due to resistance induction. To identify novel regulators of TRAIL that can aid in therapy, protein targets whose silencing sensitized breast cancer cells against TRAIL were screened with an siRNA library against 446 human apoptosis-related proteins in MDA-231 cells. Using a cationic lipopolymer (PEI-αLA) for delivery of library members, 16 siRNAs were identified that sensitized the TRAIL-induced death in MDA-231 cells. The siRNAs targeting BCL2L12 and SOD1 were further evaluated based on the novelty and their ability to sensitize TRAIL induced cell death. Silencing both targets sensitized TRAIL-mediated cell death in MDA-231 cells as well as TRAIL resistant breast cancer cells, MCF-7. Combination of TRAIL and siRNA silencing BCL2L12 had no effect in normal human umbilical vein cells and human bone marrow stromal cell. The silencing of BCL2L12 and SOD1 enhanced TRAIL-mediated apoptosis in MDA-231 cells via synergistically activating capsase-3 activity. Hence, here we report siRNAs targeting BCL2L12 and SOD1 as a novel regulator of TRAIL-induced cell death in breast cancer cells, providing a new approach for enhancing TRAIL therapy for breast cancer. The combination of siRNA targeting BCL2L12 and TRAIL can be a highly effective synergistic pair in breast cancer cells with minimal effect on the non-transformed cells. © 2017 UICC.

  10. Recreational trails reduce the density of ground-dwelling birds in protected areas.

    PubMed

    Thompson, Bill

    2015-05-01

    Recreational disturbance associated with trails has been identified as one of the major factors causing a decline of native biodiversity within protected areas. However, despite the negative impacts that recreation can have on biodiversity, providing public access to nature is critical for the future of the conservation of biodiversity. As such, many protected area managers are looking for tools to help maintain a balance between public access and biodiversity conservation. The objectives of this study were to examine the impacts of recreational trails on forest-dwelling bird communities in eastern North America, identify functional guilds which are particularly sensitive to recreational trails, and derive guidelines for trail design to assist in managing the impacts of recreational trails on forest-dwelling birds. Trails within 24 publicly owned natural areas were mapped, and breeding bird communities were described with the use of point count surveys. The density of forest birds, particularly of those species which nest or forage on the ground, were significantly positively influenced by the amount of trail-free refuge habitat. Although management options to control trail use in non-staffed protected areas are limited, this study suggests that protected area managers could design and maintain a trail network that would minimize impacts on resident wildlife, while providing recreational opportunities for visitors, by designing their trail network to maximize the area of trail-free habitat.

  11. Multiple effects of TRAIL in human carcinoma cells: Induction of apoptosis, senescence, proliferation, and cytokine production

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Levina, Vera; Marrangoni, Adele M.; DeMarco, Richard

    TRAIL is a death ligand that induces apoptosis in malignant but not normal cells. Recently the ability of TRAIL to induce proliferation in apoptosis-resistant normal and malignant cells was reported. In this study, we analyzed TRAIL effects in apoptosis sensitive MCF7, OVCAR3 and H460 human tumor cell lines. TRAIL at low concentrations preferentially induced cell proliferation. At 100 ng/ml, apoptotic death was readily observed, however surviving cells acquired higher proliferative capacity. TRAIL-stimulated production of several cytokines, IL-8, RANTES, MCP-1 and bFGF, and activation of caspases 1 and 8 was essential for this effect. Antibodies to IL-8, RANTES, and bFGF blockedmore » TRAIL-induced cell proliferation and further stimulated apoptosis. For the first time, we report that high TRAIL concentrations induced cell senescence as determined by the altered morphology and expression of several senescence markers: SA-{beta}-gal, p21{sup Waf1/Cip1}, p16{sup INK4a}, and HMGA. Caspase 9 inhibition protected TRAIL-treated cells from senescence, whereas inhibition of caspases 1 and 8 increased the yield of SLP cells. In conclusion, in cultured human carcinoma cells, TRAIL therapy results in three functional outcomes, apoptosis, proliferation and senescence. TRAIL-induced proapoptotic and prosurvival responses correlate with the strength of signaling. TRAIL-induced cytokine production is responsible for its proliferative and prosurvival effects.« less

  12. Recreational Trails Reduce the Density of Ground-Dwelling Birds in Protected Areas

    NASA Astrophysics Data System (ADS)

    Thompson, Bill

    2015-05-01

    Recreational disturbance associated with trails has been identified as one of the major factors causing a decline of native biodiversity within protected areas. However, despite the negative impacts that recreation can have on biodiversity, providing public access to nature is critical for the future of the conservation of biodiversity. As such, many protected area managers are looking for tools to help maintain a balance between public access and biodiversity conservation. The objectives of this study were to examine the impacts of recreational trails on forest-dwelling bird communities in eastern North America, identify functional guilds which are particularly sensitive to recreational trails, and derive guidelines for trail design to assist in managing the impacts of recreational trails on forest-dwelling birds. Trails within 24 publicly owned natural areas were mapped, and breeding bird communities were described with the use of point count surveys. The density of forest birds, particularly of those species which nest or forage on the ground, were significantly positively influenced by the amount of trail-free refuge habitat. Although management options to control trail use in non-staffed protected areas are limited, this study suggests that protected area managers could design and maintain a trail network that would minimize impacts on resident wildlife, while providing recreational opportunities for visitors, by designing their trail network to maximize the area of trail-free habitat.

  13. Rock Levitation by Water and Ice; an Explanation for Trails in Racetrack Playa, California

    NASA Astrophysics Data System (ADS)

    Kletetschka, G.; Ryan, A.; McKinney, E.; Fercana, G.; Schwebler, K. P.; McIntire, L.; Miller, D.; Fox, V. K.; Marbourg, J. M.; Naquin, C. A.; Krzykowski, M.; Wilde, J. R.; Kopp, E. S.; Romine, G.; Yawn, K.; Schoch, I.; McAdam, M.; Burger, D.; Rilee, K.; Jackson, B. K.; Parsons, A. M.; Cheung, C. Y.; Lunar; Planetary Science Academy

    2010-12-01

    Through a process that is nearly a century-old mystery, rock fragments race over a desiccated layer of sediment in the California desert, forming the infamous rock trails of the Racetrack playa, found in Death Valley, California. Rocks, randomly distributed over the playa, have indented grooves or trails next to them, appearing as if someone had dragged them over the playa surface when wet. Interestingly, no one has ever witnessed the movement of these rocks. Furthermore, the mechanism responsible for these trails behind the rocks has not yet been explained. Rocks have masses ranging from 0.5 kg to 300 kg, and the trails have a chaotic character, with some trails as long as 1/2 km. Each rock has a mound of raised clay on one side and a mud trail on the other; no other unusual marks are visible. A number of trails have no rocks at the end, with only a mound of solid clay where a rock once appeared to be, as if something was pushing the clay forwards to make the trail but disappeared after the trail was made. Measurements of the humidity and temperature of the sediment pointed towards a unique mechanism of how the trails could form on their own and how simple environmental changes could result in the aforementioned trails in the sediment.

  14. The Over-Selling of Fiber Optics? Cable Planning for Educational Technology.

    ERIC Educational Resources Information Center

    Kovacs, Robert E.

    1993-01-01

    Describes fiber optic cables and coaxial cables and considers when each would be appropriate for educational technology. Single mode versus multimode fiber optics are explained, advantages and disadvantages of each type of cable are discussed, and guidelines for choosing fiber optic cables and coaxial cables are offered. (LRW)

  15. Helical grip for the cable cars of San Francisco

    NASA Technical Reports Server (NTRS)

    Peyran, R. J.

    1979-01-01

    A helical cable car grip to minimize high maintenance costs of San Francisco's cable car operation is presented. The grip establishes a rolling contact between the cable and grip to reduce sliding friction and associated cable wear. The design, development, and testing of the helical cable car grip are described.

  16. 47 CFR 76.1001 - Unfair practices generally.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... control with a cable operator or cable operators, satellite cable programming vendor or vendors in which a... under common control with, such terrestrial cable programming vendor shall be deemed responsible for... programming vendor is wholly owned by, controlled by, or under common control with a cable operator or cable...

  17. 14 CFR 25.689 - Cable systems.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... STANDARDS: TRANSPORT CATEGORY AIRPLANES Design and Construction Control Systems § 25.689 Cable systems. (a) Each cable, cable fitting, turnbuckle, splice, and pulley must be approved. In addition— (1) No cable... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Cable systems. 25.689 Section 25.689...

  18. 47 CFR 76.1001 - Unfair practices generally.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... control with a cable operator or cable operators, satellite cable programming vendor or vendors in which a... under common control with, such terrestrial cable programming vendor shall be deemed responsible for... programming vendor is wholly owned by, controlled by, or under common control with a cable operator or cable...

  19. 47 CFR 76.1001 - Unfair practices generally.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... control with a cable operator or cable operators, satellite cable programming vendor or vendors in which a... under common control with, such terrestrial cable programming vendor shall be deemed responsible for... programming vendor is wholly owned by, controlled by, or under common control with a cable operator or cable...

  20. 30 CFR 57.12014 - Handling energized power cables.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Handling energized power cables. 57.12014... Electricity Surface and Underground § 57.12014 Handling energized power cables. Power cables energized to.... This does not prohibit pulling or dragging of cable by the equipment it powers when the cable is...

  1. 30 CFR 57.12014 - Handling energized power cables.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Handling energized power cables. 57.12014... Electricity Surface and Underground § 57.12014 Handling energized power cables. Power cables energized to.... This does not prohibit pulling or dragging of cable by the equipment it powers when the cable is...

  2. 30 CFR 57.12014 - Handling energized power cables.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Handling energized power cables. 57.12014... Electricity Surface and Underground § 57.12014 Handling energized power cables. Power cables energized to.... This does not prohibit pulling or dragging of cable by the equipment it powers when the cable is...

  3. 30 CFR 57.12014 - Handling energized power cables.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Handling energized power cables. 57.12014... Electricity Surface and Underground § 57.12014 Handling energized power cables. Power cables energized to.... This does not prohibit pulling or dragging of cable by the equipment it powers when the cable is...

  4. 30 CFR 57.12014 - Handling energized power cables.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Handling energized power cables. 57.12014... Electricity Surface and Underground § 57.12014 Handling energized power cables. Power cables energized to.... This does not prohibit pulling or dragging of cable by the equipment it powers when the cable is...

  5. 14 CFR 29.685 - Control system details.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... must be means to prevent the slapping of cables or tubes against other parts. (d) Cable systems must be designed as follows: (1) Cables, cable fittings, turnbuckles, splices, and pulleys must be of an acceptable kind. (2) The design of cable systems must prevent any hazardous change in cable tension throughout the...

  6. 14 CFR 27.685 - Control system details.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... must be means to prevent the slapping of cables or tubes against other parts. (d) Cable systems must be designed as follows: (1) Cables, cable fittings, turnbuckles, splices, and pulleys must be of an acceptable kind. (2) The design of the cable systems must prevent any hazardous change in cable tension throughout...

  7. Hikers and other trail users

    Treesearch

    Robert C. Lucas

    1971-01-01

    Trail users seem neglected. Trail systems are limited, largely relics of fire control rather than designed for recreation; and total trail miles are probably declining. On the other hand, participation in various kinds of trail-oriented recreation is substantial and growing. Most activity is for short periods of time close to participants' homes. A varied and...

  8. 75 FR 37462 - Official Trail Marker for the Captain John Smith Chesapeake National Historic Trail

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    ... DEPARTMENT OF THE INTERIOR National Park Service Official Trail Marker for the Captain John Smith Chesapeake National Historic Trail AGENCY: National Parks Service, Interior. ACTION: Official Insignia, Designation. Authority: National Trails System Act, 16 U.S.C. 124(a) and 1246(c) and Protection of Official...

  9. 76 FR 26767 - Captain John Smith Chesapeake National Historic Trail Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-09

    ... Trail Advisory Council AGENCY: National Park Service, Interior. ACTION: Notice of meeting. SUMMARY: As... that the Advisory Committee on the Captain John Smith Chesapeake National Historic Trail will hold a meeting. Designated through an amendment to the National Trails System Act (16 U.S.C. 1241), the trail...

  10. 76 FR 52691 - Captain John Smith Chesapeake National Historic Trail Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-23

    ... Trail Advisory Council AGENCY: National Park Service, Interior. ACTION: Notice of meeting. SUMMARY: As... that the Advisory Committee on the Captain John Smith Chesapeake National Historic Trail will hold a meeting. Designated through an amendment to the National Trails System Act (16 U.S.C. 1241), the trail...

  11. 36 CFR 13.1308 - Harding Icefield Trail.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Harding Icefield Trail. 13... Provisions § 13.1308 Harding Icefield Trail. The Harding Icefield Trail from the junction with the main paved trail near Exit Glacier to the emergency hut near the terminus is closed to— (a) Camping within 1/8 mile...

  12. 36 CFR 261.55 - National Forest System trails.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false National Forest System trails... PROHIBITIONS Prohibitions in Areas Designated by Order § 261.55 National Forest System trails. When provided by... National Forest System trail: (a) Being on a trail. (b) Using any type of vehicle prohibited by the order...

  13. 76 FR 8992 - National Trails System Act and Railroad Rights-of-Way

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-16

    ...] National Trails System Act and Railroad Rights-of-Way AGENCY: Surface Transportation Board, DOT. ACTION... procedures regarding the use of railroad rights-of-way for railbanking and interim trail use under the National Trails System Act (Trails Act). DATES: Comments are due by April 12, 2011; replies are due by May...

  14. 77 FR 33206 - Combined Notice of Filings #2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-05

    ...: ER12-1848-000. Applicants: High Trail Wind Farm, LLC. Description: High Trail Wind Farm, LLC submits tariff filing per 35: High Trail Wind Farm First Revised MBR to be effective 5/26/2012. Filed Date: 5/25...-000. Applicants: Old Trail Wind Farm, LLC. Description: Old Trail Wind Farm, LLC submits tariff filing...

  15. Assessing soil erosion on trails: A comparison of techniques

    Treesearch

    Mark C. Jewell; William E. Hammitt

    2000-01-01

    Reports of trail degradation have been increasing in different wildernesses. This impact has become a common concern among managers. Deteriorating tread conditions of trails are increasing, as is concern at protected areas worldwide. In order to make objective and timely trail resource decisions, managers need to have effective and efficient methods of assessing trail...

  16. National recreation trails: an overview

    Treesearch

    Joanne F. Tynon; James A. Harding; Deborah J. Chavez

    1998-01-01

    Since the establishment of the National Trails System in 1968, 822 trails have been designated as National Recreation Trails (NRT). These trails support a wide range of activities, including but not limited to hiking, mountain biking, cross country skiing and horseback riding. In short, NRTs can be found across a diversity of geographic settings and are frequent...

  17. Trail-following responses of the Argentine ant,Iridomyrmex humilis (Mayr), to a synthetic trail pheromone component and analogs.

    PubMed

    Van Vorhis Key, S E; Baker, T C

    1982-01-01

    Behavioral evidence indicates that (Z)-9-hexadecenal (Z9-16∶ALD) is a trail pheromone component ofIridomyrmex humilis, and that the true trail pheromone may be multicomponent. Trail-following responses ofI. humilis workers to several concentrations of syntheticZ9-16∶ALD, a constituent of the Pavan's gland, were found to be comparable to responses to gaster extract trails containing ca. 100 times lessZ9-16∶ALD. Of the five aldehyde analogs tested, only (Z)-7-hexadecenal (Z7-16∶ALD) elicited significant trail-following. However, following responses to severalZ9-16∶ALD-Z7-16∶ALD combinations were lower than responses toZ9-16∶ALD alone. Trails on filter paper of biologically relevant concentrations ofZ9-16∶ALD lose activity within 2 hr in the laboratory. The release rate ofZ9-16∶ALD measured from filter paper trails was 0.25 ± 0.10 pg/cm-sec. This was used to estimate the trail-following threshold for this compound of Argentine ant workers.

  18. Assessing the influence of sustainable trail design and maintenance on soil loss.

    PubMed

    Marion, Jeffrey L; Wimpey, Jeremy

    2017-03-15

    Natural-surfaced trail systems are an important infrastructure component providing a means for accessing remote protected natural area destinations. The condition and usability of trails is a critical concern of land managers charged with providing recreational access while preserving natural conditions, and to visitors seeking high quality recreational opportunities and experiences. While an adequate number of trail management publications provide prescriptive guidance for designing, constructing, and maintaining natural-surfaced trails, surprisingly little research has been directed at providing a scientific basis for this guidance. Results from a review of the literature and three scientific studies are presented to model and clarify the influence of factors that substantially influence trail soil loss and that can be manipulated by trail professionals to sustain high traffic while minimizing soil loss over time. Key factors include trail grade, slope alignment angle, tread drainage features, and the amount of rock in tread substrates. A new Trail Sustainability Rating is developed and offered as a tool for evaluating or improving the sustainability of existing or new trails. Published by Elsevier Ltd.

  19. Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors

    PubMed Central

    Iurlaro, Raffaella; Püschel, Franziska; León-Annicchiarico, Clara Lucía; O'Connor, Hazel; Martin, Seamus J.; Palou-Gramón, Daniel; Lucendo, Estefanía

    2017-01-01

    ABSTRACT Metabolic stress occurs frequently in tumors and in normal tissues undergoing transient ischemia. Nutrient deprivation triggers, among many potential cell death-inducing pathways, an endoplasmic reticulum (ER) stress response with the induction of the integrated stress response transcription factor ATF4. However, how this results in cell death remains unknown. Here we show that glucose deprivation triggered ER stress and induced the unfolded protein response transcription factors ATF4 and CHOP. This was associated with the nontranscriptional accumulation of TRAIL receptor 1 (TRAIL-R1) (DR4) and with the ATF4-mediated, CHOP-independent induction of TRAIL-R2 (DR5), suggesting that cell death in this context may involve death receptor signaling. Consistent with this, the ablation of TRAIL-R1, TRAIL-R2, FADD, Bid, and caspase-8 attenuated cell death, although the downregulation of TRAIL did not, suggesting ligand-independent activation of TRAIL receptors. These data indicate that stress triggered by glucose deprivation promotes the ATF4-dependent upregulation of TRAIL-R2/DR5 and TRAIL receptor-mediated cell death. PMID:28242652

  20. Actin cable dynamics in budding yeast

    PubMed Central

    Yang, Hyeong-Cheol; Pon, Liza A.

    2002-01-01

    Actin cables, bundles of actin filaments that align along the long axis of budding yeast, are crucial for establishment of cell polarity. We fused green fluorescent protein (GFP) to actin binding protein 140 (Abp140p) and visualized actin cable dynamics in living yeast. We detected two populations of actin cables: (i) bud-associated cables, which extend from the bud along the mother-bud axis, and (ii) randomly oriented cables, which are relatively short. Time-lapse imaging of Abp140p–GFP revealed an apparent increase in the length of bud-associated actin cables. Analysis of movement of Abp140p–GFP fiduciary marks on bud-associated cables and fluorescence loss in photobleaching experiments revealed that this apparent elongation occurs by assembly of new material at the end of the cable within the bud and movement of the opposite end of the cable toward the tip of the mother cell distal to the bud. The rate of extension of the tip of an elongating actin cable is 0.29 ± 0.08 μm/s. Latrunculin A (Lat-A) treatment completely blocked this process. We also observed movement of randomly oriented cables around the cortex of cells at a rate of 0.59 ± 0.14 μm/s. Mild treatment with Lat-A did not affect the velocity of movement of randomly oriented cables. However, Lat-A treatment did increase the number of randomly oriented, motile cables per cell. Our observations suggest that establishment of bud-associated actin cables during the cell cycle is accomplished not by realignment of existing cables but by assembly of new cables within the bud or bud neck, followed by elongation. PMID:11805329

  1. Influence of TRAIL gene on biomechanical properties of the human leukemic cell line Jurkat.

    PubMed

    Yao, Weijuan; Chen, Kai; Wang, Xinjuan; Xie, Lide; Wen, Zongyao; Yan, Zongyi; Chien, Shu

    2002-12-01

    We cloned the cDNA fragment of human TNF-related apoptosis inducing ligand (TRAIL) into RevTet-On, a Tet-regulated and high-level gene expression system. Making use of the TRAIL gene expression system in Jurkat as a cell model, we studied the influence of TRAIL gene on the biomechanics properties of Jurkat through measuring changes of cellular biomechanics properties before and after the TRAIL gene expression, which was induced by adding tetracycline derivative doxycycline (Dox). The results indicated that the TRAIL gene expression led to significant changes in cellular biomechanics properties. The osmotic fragility increased and the cell stiffness increased after the expression of TRAIL gene. Thus, the apoptosis-inducing TRAIL gene caused significant changes in the biomechanics properties of Jurkat cells.

  2. Investigation of the strength of shielded and unshielded underwater electrical cables

    NASA Astrophysics Data System (ADS)

    Glowe, D. E.; Arnett, S. L.

    1981-09-01

    The mechanical properties of shielded and unshielded submarine cables (MIL-C-915/8E) were investigated to determine the effect of shielding on cable life, performance, and reliability. Ten cables (five shielded and five unshielded) were selected for laboratory evaluation. A mission profile was developed to establish the mechanical stress limits that cables must endure in service and a test sequence designed to measure tensile strength, flexural abrasion endurance, crush resistance, creep under static tension, and performance in a hull-stuffing tube. The results of this program showed that: (1) DSS-2 cable does not have adequate tensile strength and should have a strength member added. DSS-3 and larger cables have adequate tensile strength with or without the shield; (2) Unshielded DSS-3 type cable does not perform satisfactorily in hull-stuffing tubes; (3) Shielding is not required to meet mission profile specifications for cable crush or flexural abrasion resistance; (4) Construction parameters other than shielding can significantly affect mechanical performance of cable; (5) Unshielded cable construction can result in increased reliability since it permits a thicker single-jacket construction; and (6) Unshielded cable construction can reduce the cost of cable by 8 to 20 percent.

  3. Development of a single-phase 30 m HTS power cable

    NASA Astrophysics Data System (ADS)

    Cho, Jeonwook; Bae, Joon-Han; Kim, Hae-Jong; Sim, Ki-Deok; Kim, Seokho; Jang, Hyun-Man; Lee, Chang-Young; Kim, Dong-Wook

    2006-05-01

    HTS power transmission cables appear to be the replacement and retrofitting of underground cables in urban areas and HTS power transmission cable offers a number of technical and economic merits compared to the normal conductor cable system. A 30 m long, single-phase 22.9 kV class HTS power transmission cable system has been developed by Korea Electrotechnology Research Institute (KERI), LS Cable Ltd., and Korea Institute of Machinery and Materials (KIMM), which is one of the 21st century frontier project in Korea since 2001. The HTS power cable has been developed, cooled down and tested to obtain realistic thermal and electrical data on HTS power cable system. The evaluation results clarified such good performance of HTS cable that DC critical current of the HTS cable was 3.6 kA and AC loss was 0.98 W/m at 1260 Arms and shield current was 1000 Arms. These results proved the basic properties for 22.9 kV HTS power cable. As a next step, we have been developing a 30 m, three-phase 22.9 kV, 50 MV A HTS power cable system and long term evaluation is in progress now.

  4. A New Multiconstraint Method for Determining the Optimal Cable Stresses in Cable-Stayed Bridges

    PubMed Central

    Asgari, B.; Osman, S. A.; Adnan, A.

    2014-01-01

    Cable-stayed bridges are one of the most popular types of long-span bridges. The structural behaviour of cable-stayed bridges is sensitive to the load distribution between the girder, pylons, and cables. The determination of pretensioning cable stresses is critical in the cable-stayed bridge design procedure. By finding the optimum stresses in cables, the load and moment distribution of the bridge can be improved. In recent years, different research works have studied iterative and modern methods to find optimum stresses of cables. However, most of the proposed methods have limitations in optimising the structural performance of cable-stayed bridges. This paper presents a multiconstraint optimisation method to specify the optimum cable forces in cable-stayed bridges. The proposed optimisation method produces less bending moments and stresses in the bridge members and requires shorter simulation time than other proposed methods. The results of comparative study show that the proposed method is more successful in restricting the deck and pylon displacements and providing uniform deck moment distribution than unit load method (ULM). The final design of cable-stayed bridges can be optimised considerably through proposed multiconstraint optimisation method. PMID:25050400

  5. A new multiconstraint method for determining the optimal cable stresses in cable-stayed bridges.

    PubMed

    Asgari, B; Osman, S A; Adnan, A

    2014-01-01

    Cable-stayed bridges are one of the most popular types of long-span bridges. The structural behaviour of cable-stayed bridges is sensitive to the load distribution between the girder, pylons, and cables. The determination of pretensioning cable stresses is critical in the cable-stayed bridge design procedure. By finding the optimum stresses in cables, the load and moment distribution of the bridge can be improved. In recent years, different research works have studied iterative and modern methods to find optimum stresses of cables. However, most of the proposed methods have limitations in optimising the structural performance of cable-stayed bridges. This paper presents a multiconstraint optimisation method to specify the optimum cable forces in cable-stayed bridges. The proposed optimisation method produces less bending moments and stresses in the bridge members and requires shorter simulation time than other proposed methods. The results of comparative study show that the proposed method is more successful in restricting the deck and pylon displacements and providing uniform deck moment distribution than unit load method (ULM). The final design of cable-stayed bridges can be optimised considerably through proposed multiconstraint optimisation method.

  6. The influence of use-related, environmental, and managerial factors on soil loss from recreational trails.

    PubMed

    Olive, Nathaniel D; Marion, Jeffrey L

    2009-03-01

    Recreational uses of unsurfaced trails inevitably result in their degradation, with the type and extent of resource impact influenced by factors such as soil texture, topography, climate, trail design and maintenance, and type and amount of use. Of particular concern, the loss of soil through erosion is generally considered a significant and irreversible form of trail impact. This research investigated the influence of several use-related, environmental, and managerial factors on soil loss on recreational trails and roads at Big South Fork National River and Recreation Area, a unit of the U.S. National Park Service. Regression modeling revealed that trail position, trail slope alignment angle, grade, water drainage, and type of use are significant determinants of soil loss. The introduction of individual and groups of variables into a series of regression models provides improved understanding and insights regarding the relative influence of these variables, informing the selection of more effective trail management actions. Study results suggest that trail erosion can be minimized by avoiding "fall-line" alignments, steep grades, and valley-bottom alignments near streams, installing and maintaining adequate densities of tread drainage features, applying gravel to harden treads, and reducing horse and all-terrain vehicle use or restricting them to more resistant routes. This research also sought to develop a more efficient Variable Cross-Sectional Area method for assessing soil loss on trails. This method permitted incorporation of CSA measures in a representative sampling scheme applied to a large (24%) sample of the park's 526 km trail system. The variety of soil loss measures derived from the Variable CSA method, including extrapolated trail-wide soil loss estimates, permit an objective quantification of soil erosion on recreational trails and roads. Such data support relational analyses to increase understanding of trail degradation, and long-term monitoring of the natural and recreational integrity of the trail system infrastructure.

  7. The influence of use-related, environmental, and managerial factors on soil loss from recreational trails

    USGS Publications Warehouse

    Olive, Nathaniel D.; Marion, Jeffrey L.

    2009-01-01

    Recreational uses of unsurfaced trails inevitably result in their degradation, with the type and extent of resource impact influenced by factors such as soil texture, topography, climate, trail design and maintenance, and type and amount of use. Of particular concern, the loss of soil through erosion is generally considered a significant and irreversible form of trail impact. This research investigated the influence of several use-related, environmental, and managerial factors on soil loss on recreational trails and roads at Big South Fork National River and Recreation Area, a unit of the U.S. National Park Service. Regression modeling revealed that trail position, trail slope alignment angle, grade, water drainage, and type of use are significant determinants of soil loss. The introduction of individual and groups of variables into a series of regression models provides improved understanding and insights regarding the relative influence of these variables, informing the selection of more effective trail management actions. Study results suggest that trail erosion can be minimized by avoiding “fall-line” alignments, steep grades, and valley-bottom alignments near streams, installing and maintaining adequate densities of tread drainage features, applying gravel to harden treads, and reducing horse and all-terrain vehicle use or restricting them to more resistant routes.This research also sought to develop a more efficient Variable Cross-Sectional Area method for assessing soil loss on trails. This method permitted incorporation of CSA measures in a representative sampling scheme applied to a large (24%) sample of the park's 526 km trail system. The variety of soil loss measures derived from the Variable CSA method, including extrapolated trail-wide soil loss estimates, permit an objective quantification of soil erosion on recreational trails and roads. Such data support relational analyses to increase understanding of trail degradation, and long-term monitoring of the natural and recreational integrity of the trail system infrastructure.

  8. The Influence of Snowmobile Trails on Coyote Movements during Winter in High-Elevation Landscapes

    PubMed Central

    Gese, Eric M.; Dowd, Jennifer L. B.; Aubry, Lise M.

    2013-01-01

    Competition between sympatric carnivores has long been of interest to ecologists. Increased understanding of these interactions can be useful for conservation planning. Increased snowmobile traffic on public lands and in habitats used by Canada lynx (Lynx canadensis) remains controversial due to the concern of coyote (Canis latrans) use of snowmobile trails and potential competition with lynx. Determining the variables influencing coyote use of snowmobile trails has been a priority for managers attempting to conserve lynx and their critical habitat. During 2 winters in northwest Wyoming, we backtracked coyotes for 265 km to determine how varying snow characteristics influenced coyote movements; 278 km of random backtracking was conducted simultaneously for comparison. Despite deep snow (>1 m deep), radio-collared coyotes persisted at high elevations (>2,500 m) year-round. All coyotes used snowmobile trails for some portion of their travel. Coyotes used snowmobile trails for 35% of their travel distance (random: 13%) for a mean distance of 149 m (random: 59 m). Coyote use of snowmobile trails increased as snow depth and penetrability off trails increased. Essentially, snow characteristics were most influential on how much time coyotes spent on snowmobile trails. In the early months of winter, snow depth was low, yet the snow column remained dry and the coyotes traveled off trails. As winter progressed and snow depth increased and snow penetrability increased, coyotes spent more travel distance on snowmobile trails. As spring approached, the snow depth remained high but penetrability decreased, hence coyotes traveled less on snowmobile trails because the snow column off trail was more supportive. Additionally, coyotes traveled closer to snowmobile trails than randomly expected and selected shallower snow when traveling off trails. Coyotes also preferred using snowmobile trails to access ungulate kills. Snow compaction from winter recreation influenced coyote movements within an area containing lynx and designated lynx habitat. PMID:24367565

  9. The influence of snowmobile trails on coyote movements during winter in high-elevation landscapes.

    PubMed

    Gese, Eric M; Dowd, Jennifer L B; Aubry, Lise M

    2013-01-01

    Competition between sympatric carnivores has long been of interest to ecologists. Increased understanding of these interactions can be useful for conservation planning. Increased snowmobile traffic on public lands and in habitats used by Canada lynx (Lynx canadensis) remains controversial due to the concern of coyote (Canis latrans) use of snowmobile trails and potential competition with lynx. Determining the variables influencing coyote use of snowmobile trails has been a priority for managers attempting to conserve lynx and their critical habitat. During 2 winters in northwest Wyoming, we backtracked coyotes for 265 km to determine how varying snow characteristics influenced coyote movements; 278 km of random backtracking was conducted simultaneously for comparison. Despite deep snow (>1 m deep), radio-collared coyotes persisted at high elevations (>2,500 m) year-round. All coyotes used snowmobile trails for some portion of their travel. Coyotes used snowmobile trails for 35% of their travel distance (random: 13%) for a mean distance of 149 m (random: 59 m). Coyote use of snowmobile trails increased as snow depth and penetrability off trails increased. Essentially, snow characteristics were most influential on how much time coyotes spent on snowmobile trails. In the early months of winter, snow depth was low, yet the snow column remained dry and the coyotes traveled off trails. As winter progressed and snow depth increased and snow penetrability increased, coyotes spent more travel distance on snowmobile trails. As spring approached, the snow depth remained high but penetrability decreased, hence coyotes traveled less on snowmobile trails because the snow column off trail was more supportive. Additionally, coyotes traveled closer to snowmobile trails than randomly expected and selected shallower snow when traveling off trails. Coyotes also preferred using snowmobile trails to access ungulate kills. Snow compaction from winter recreation influenced coyote movements within an area containing lynx and designated lynx habitat.

  10. ATOC/Pioneer Seamount cable after 8 years on the seafloor: Observations, environmental impact

    NASA Astrophysics Data System (ADS)

    Kogan, Irina; Paull, Charles K.; Kuhnz, Linda A.; Burton, Erica J.; von Thun, Susan; Gary Greene, H.; Barry, James P.

    2006-04-01

    A study was conducted on the impacts of the presence of the Acoustic Thermometry of Ocean Climate (ATOC)/Pioneer Seamount cable on the benthos from nearshore waters adjacent to its origin at Pillar Point Air Force Station in Half Moon Bay, California to its terminus 95 km along its length on Pioneer Seamount. The coaxial Type SD cable was installed, unburied on the seafloor in 1995. Thirteen sites along the cable route were surveyed using the Monterey Bay Aquarium Research Institute (MBARI) ROVs Ventana and Tiburon equipped with cable-tracking tools. Quantitative comparisons of biological communities and seafloor features between cable and control sites were performed at nine stations. Forty-two hours of video footage and 138 push cores were collected over 15.1 km of seafloor. Approximately 12.1 km of the cable was observed (13% of the cable route). This study documents the appearance and condition of the cable and the underlying seafloor, and the effects of the cable on biological communities along its route. Limited self-burial of the cable has occurred during the 8-year deployment, particularly over the continental shelf and upper slope. Cable strumming by nearshore wave action has incised rocky siltstone outcrops. Several observations of kinks and snags in the cable on the upper slope (˜240 m depth) suggest contact with trawling gear. Few changes in the abundance or distribution of benthic fauna were detectable from video observations (epifaunal) and sediment core samples (infauna). Of 17 megafaunal groups and 19 infaunal taxa, no tests evaluating the overall effect of the cable were statistically significant. While these results indicate that the biological impacts of the cable are minor at most, three megafaunal groups exhibited cable-related changes at one or more stations. Actiniarians (sea anemones) colonized the cable when it was exposed on the seafloor, and were therefore generally more abundant on the cable than in surrounding, sediment-dominated seafloor habitats. Some fishes were also more abundant near the cable, apparently due to the higher habitat complexity provided by the cable. The study also documents general changes in the benthos across the Central California continental margin.

  11. Burning Characteristics and Flammability of PVC Cables in Groups

    NASA Technical Reports Server (NTRS)

    Mikado, T.; Akita, K.

    1988-01-01

    Because burning cables represent a danger of increasing secondary damage it is of utmost importance for disaster prevention to correctly evaluate the combustion characteristics of cable. However, in many cases cable is laid out in bundles complicating the combustion characteristics. A situation has developed where group cable characteristics are not completely understood. A new method is developed for testing the combustion of high polymer type cable and earlier reports gave comparative combustion measurement results. It was learned that there is considerable difference between the combustion characteristics of the grouped cables and those of single cables. This study is supplemental research concerning the special behavior of group PVC cables, throwing some light on their combustion characteristics.

  12. OTEC riser cable model and prototype testing

    NASA Astrophysics Data System (ADS)

    Kurt, J. P.; Schultz, J. A.; Roblee, L. H. S.

    1981-12-01

    Two different OTEC riser cables have been developed to span the distance between a floating OTEC power plant and the ocean floor. The major design concerns for a riser cable in the dynamic OTEC environment are fatigue, corrosion, and electrical/mechanical aging of the cable components. The basic properties of the cable materials were studied through tests on model cables and on samples of cable materials. Full-scale prototype cables were manufactured and were tested to measure their electrical and mechanical properties and performance. The full-scale testing was culminated by the electrical/mechanical fatigue test, which exposes full-scale cables to simultaneous tension, bending and electrical loads, all in a natural seawater environment.

  13. Non-motorized winter recreation impacts to snowmelt erosion, Tronsen Basin, Eastern Cascades, Washington.

    PubMed

    Eagleston, Holly; Rubin, Charles

    2013-01-01

    Many recreation impact studies have focused on summer activities, but the environmental impact of winter recreation is poorly characterized. This study characterizes the impact of snowshoe/cross-country ski compaction and snowmelt erosion on trails. Trail cross-sectional profiles were measured before and after the winter season to map changes in erosion due to winter recreation. Compacted snow on the trail was 30 % more dense than snowpack off the trail before spring melt out. Snow stayed on the trail 7 days longer. Soil and organic material was transported after spring snowmelt with -9.5 ± 2.4 cm(2) total erosion occurring on the trail transects and -3.8 ± 2.4 cm(2) total erosion occurring on the control transect (P = 0.046). More material was transported on the trail than on the control, 12.9± 2.4 versus 6.0 ± 2.4 cm(2) (P = 0.055), however, deposition levels remained similar on the trail and on the control. Snow compaction from snowshoers and cross-country skiers intensified erosion. Trail gradient was found to be significantly correlated to net changes in material on the trail (R (2) = 0.89, ρ = -0.98, P = 0.005). This study provides a baseline, showing that non-motorized winter recreation does impact soil erosion rates but more studies are needed. Trail managers should consider mitigation such as water bars, culverts and avoiding building trails with steep gradients, in order to reduce loss of soils on trails and subsequent sedimentation of streams.

  14. Non-motorized Winter Recreation Impacts to Snowmelt Erosion, Tronsen Basin, Eastern Cascades, Washington

    NASA Astrophysics Data System (ADS)

    Eagleston, Holly; Rubin, Charles

    2013-01-01

    Many recreation impact studies have focused on summer activities, but the environmental impact of winter recreation is poorly characterized. This study characterizes the impact of snowshoe/cross-country ski compaction and snowmelt erosion on trails. Trail cross-sectional profiles were measured before and after the winter season to map changes in erosion due to winter recreation. Compacted snow on the trail was 30 % more dense than snowpack off the trail before spring melt out. Snow stayed on the trail 7 days longer. Soil and organic material was transported after spring snowmelt with -9.5 ± 2.4 cm2 total erosion occurring on the trail transects and -3.8 ± 2.4 cm2 total erosion occurring on the control transect ( P = 0.046). More material was transported on the trail than on the control, 12.9± 2.4 versus 6.0 ± 2.4 cm2 ( P = 0.055), however, deposition levels remained similar on the trail and on the control. Snow compaction from snowshoers and cross-country skiers intensified erosion. Trail gradient was found to be significantly correlated to net changes in material on the trail ( R 2 = 0.89, ρ = -0.98, P = 0.005). This study provides a baseline, showing that non-motorized winter recreation does impact soil erosion rates but more studies are needed. Trail managers should consider mitigation such as water bars, culverts and avoiding building trails with steep gradients, in order to reduce loss of soils on trails and subsequent sedimentation of streams.

  15. Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway.

    PubMed

    Allen, Joshua E; Krigsfeld, Gabriel; Patel, Luv; Mayes, Patrick A; Dicker, David T; Wu, Gen Sheng; El-Deiry, Wafik S

    2015-05-01

    We previously reported the identification of ONC201/TIC10, a novel small molecule inducer of the human TRAIL gene that improves efficacy-limiting properties of recombinant TRAIL and is in clinical trials in advanced cancers based on its promising safety and antitumor efficacy in several preclinical models. We performed a high throughput luciferase reporter screen using the NCI Diversity Set II to identify TRAIL-inducing compounds. Small molecule-mediated induction of TRAIL reporter activity was relatively modest and the majority of the hit compounds induced low levels of TRAIL upregulation. Among the candidate TRAIL-inducing compounds, TIC9 and ONC201/TIC10 induced sustained TRAIL upregulation and apoptosis in tumor cells in vitro and in vivo. However, ONC201/TIC10 potentiated tumor cell death while sparing normal cells, unlike TIC9, and lacked genotoxicity in normal fibroblasts. Investigating the effects of TRAIL-inducing compounds on cell signaling pathways revealed that TIC9 and ONC201/TIC10, which are the most potent inducers of cell death, exclusively activate Foxo3a through inactivation of Akt/ERK to upregulate TRAIL and its pro-apoptotic death receptor DR5. These studies reveal the selective activity of ONC201/TIC10 that led to its selection as a lead compound for this novel class of antitumor agents and suggest that ONC201/TIC10 is a unique inducer of the TRAIL pathway through its concomitant regulation of the TRAIL ligand and its death receptor DR5.

  16. Trail Pheromone of the Argentine Ant, Linepithema humile (Mayr) (Hymenoptera: Formicidae)

    PubMed Central

    Choe, Dong-Hwan; Villafuerte, David B.; Tsutsui, Neil D.

    2012-01-01

    The Argentine ant (Linepithema humile) is recognized as one of the world's most damaging invasive species. One reason for the ecological dominance of introduced Argentine ant populations is their ability to dominate food and habitat resources through the rapid mobilization and recruitment of thousands of workers. More than 30 years ago, studies showed that (Z)-9-hexadecenal strongly attracted Argentine ant workers in a multi-choice olfactometer, suggesting that (Z)-9-hexadecenal might be the trail pheromone, or a component of a trail pheromone mixture. Since then, numerous studies have considered (Z)-9-hexadecenal as the key component of the Argentine ant trails. Here, we report the first chemical analyses of the trails laid by living Argentine ants and find that (Z)-9-hexadecenal is not present in a detectible quantity. Instead, two iridoids, dolichodial and iridomyrmecin, appear to be the primary chemical constituents of the trails. Laboratory choice tests confirmed that Argentine ants were attracted to artificial trails comprised of these two chemicals significantly more often than control trails. Although (Z)-9-hexadecenal was not detected in natural trails, supplementation of artificial dolichodial+iridomyrmecin trails with an extremely low concentraion of (Z)-9-hexadecenal did increase the efficacy of the trail-following behavior. In stark contrast with previous dogma, our study suggests that dolichodial and iridomyrmecin are major components of the Argentine ant trail pheromone. (Z)-9-hexadecenal may act in an additive manner with these iridoids, but it does not occur in detectable quantities in Argentine ant recruitment trails. PMID:23028739

  17. Lactate dehydrogenase regulation in aged skeletal muscle: Regulation by anabolic steroids and functional overload.

    PubMed

    Washington, Tyrone A; Healey, Julie M; Thompson, Raymond W; Lowe, Larry L; Carson, James A

    2014-09-01

    Aging alters the skeletal muscle response to overload-induced growth. The onset of functional overload is characterized by increased myoblast proliferation and an altered muscle metabolic profile. The onset of functional overload is associated with increased energy demands that are met through the interconversion of lactate and pyruvate via the activity of lactate dehydrogenase (LDH). Testosterone targets many of the processes activated at the onset of functional overload. However, the effect of aging on this metabolic plasticity at the onset of functional overload and how anabolic steroid administration modulates this response is not well understood. The purpose of this study was to determine if aging would alter overload-induced LDH activity and expression at the onset of functional overload and whether anabolic steroid administration would modulate this response. Five-month and 25-month male Fischer 344xF1 BRN were given nandrolone decanoate (ND) or sham injections for 14days and then the plantaris was functionally overloaded (OV) for 3days by synergist ablation. Aging reduced muscle LDH-A & LDH-B activity 70% (p<0.05). Aging also reduced LDH-A mRNA abundance, however there was no age effect on LDH-B mRNA abundance. In 5-month muscle, both ND and OV decreased LDH-A and LDH-B activity. However, there was no synergistic or additive effect. In 5-month muscle, ND and OV decreased LDH-A mRNA expression with no change in LDH-B expression. In 25-month muscle, ND and OV increased LDH-A and LDH-B activity. LDH-A mRNA expression was not altered by ND or OV in aged muscle. However, there was a main effect of OV to decrease LDH-B mRNA expression. There was also an age-induced LDH isoform shift. ND and OV treatment increased the "fast" LDH isoforms in aged muscle, whereas ND and OV increased the "slow" isoforms in young muscle. Our study provides evidence that aging alters aspects of skeletal muscle metabolic plasticity normally induced by overload and anabolic steroid administration. Copyright © 2014 Elsevier Inc. All rights reserved.

  18. 47 CFR 32.2422 - Underground cable.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... cable. This subsidiary record category shall include the original cost of optical fiber cable and other..., Buried Cable. (d) The cost of cables leading from the main distributing frame or equivalent to central...

  19. 47 CFR 32.2422 - Underground cable.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... cable. This subsidiary record category shall include the original cost of optical fiber cable and other..., Buried Cable. (d) The cost of cables leading from the main distributing frame or equivalent to central...

  20. 47 CFR 32.2422 - Underground cable.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... cable. This subsidiary record category shall include the original cost of optical fiber cable and other..., Buried Cable. (d) The cost of cables leading from the main distributing frame or equivalent to central...

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