Sample records for transfer function itf

  1. The recalibration of the IUE scientific instrument

    NASA Technical Reports Server (NTRS)

    Imhoff, Catherine L.; Oliversen, Nancy A.; Nichols-Bohlin, Joy; Casatella, Angelo; Lloyd, Christopher

    1988-01-01

    The IUE instrument was recalibrated because of long time-scale changes in the scientific instrument, a better understanding of the performance of the instrument, improved sets of calibration data, and improved analysis techniques. Calibrations completed or planned include intensity transfer functions (ITF), low-dispersion absolute calibrations, high-dispersion ripple corrections and absolute calibrations, improved geometric mapping of the ITFs to spectral images, studies to improve the signal-to-noise, enhanced absolute calibrations employing corrections for time, temperature, and aperture dependence, and photometric and geometric calibrations for the FES.

  2. Implementation and extension of the impulse transfer function method for future application to the space shuttle project. Volume 2: Program description and user's guide

    NASA Technical Reports Server (NTRS)

    Patterson, G.

    1973-01-01

    The data processing procedures and the computer programs were developed to predict structural responses using the Impulse Transfer Function (ITF) method. There are three major steps in the process: (1) analog-to-digital (A-D) conversion of the test data to produce Phase I digital tapes (2) processing of the Phase I digital tapes to extract ITF's and storing them in a permanent data bank, and (3) predicting structural responses to a set of applied loads. The analog to digital conversion is performed by a standard package which will be described later in terms of the contents of the resulting Phase I digital tape. Two separate computer programs have been developed to perform the digital processing.

  3. Round robin test on V-shape bio-imaging transfer standard for determination of the instrument transfer function of 3D optical profilers

    NASA Astrophysics Data System (ADS)

    Bermudez, Carlos; Artigas, Roger; Martinez, Pol; Nolvi, Anton; Järvinen, Miikka; Hæggström, Edward; Kassamakov, Ivan

    2018-02-01

    A V-shape Bio-Transfer-Standard (V-BTS), developed and produced at the University of Helsinki (UH), was measured in two laboratories. In comparison to Siemens Star calibration specimens, the V-BTS performs better at high lateral frequencies close to the diffraction limit of the optical instrument. This permits determining of the Instrument Transfer Function (ITF). The V-BTS features two lipid bilayer steps that partly overlap each other at an angle of 20°, with an average height of 4.6 +/- 0.1 nm. The Round Robin (RR) test aims to determine whether the V-BTS and the developed application protocol work with different optical profilers in different laboratories. First the artefact was measured at Sensofar-Tech, S.L. using an S-neox profiler working in Phase Shifting Interferometry mode. Then V-BTS was measured at UH using a custom-built Scanning White Light Interferometer. All measurements done by four different operators at the two laboratories have a range or standard deviation of +/-0.1 nm which agrees with the theoretical estimates and with measurements done using an atomic force microscope and with a surface plasmon resonance based instrument. The RR results show the applicability of the V-BTS for calibration and for ITF characterization of 3D optical profilers.

  4. Integrated Test Facility (ITF)

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The NASA-Dryden Integrated Test Facility (ITF), also known as the Walter C. Williams Research Aircraft Integration Facility (RAIF), provides an environment for conducting efficient and thorough testing of advanced, highly integrated research aircraft. Flight test confidence is greatly enhanced by the ability to qualify interactive aircraft systems in a controlled environment. In the ITF, each element of a flight vehicle can be regulated and monitored in real time as it interacts with the rest of the aircraft systems. Testing in the ITF is accomplished through automated techniques in which the research aircraft is interfaced to a high-fidelity real-time simulation. Electric and hydraulic power are also supplied, allowing all systems except the engines to function as if in flight. The testing process is controlled by an engineering workstation that sets up initial conditions for a test, initiates the test run, monitors its progress, and archives the data generated. The workstation is also capable of analyzing results of individual tests, comparing results of multiple tests, and producing reports. The computers used in the automated aircraft testing process are also capable of operating in a stand-alone mode with a simulation cockpit, complete with its own instruments and controls. Control law development and modification, aerodynamic, propulsion, guidance model qualification, and flight planning -- functions traditionally associated with real-time simulation -- can all be performed in this manner. The Remotely Augmented Vehicles (RAV) function, now located in the ITF, is a mainstay in the research techniques employed at Dryden. This function is used for tests that are too dangerous for direct human involvement or for which computational capacity does not exist onboard a research aircraft. RAV provides the researcher with a ground-based computer that is radio linked to the test aircraft during actual flight. The Ground Vibration Testing (GVT) system, formerly housed in the Thermostructural Laboratory, now also resides in the ITF. In preparing a research aircraft for flight testing, it is vital to measure its structural frequencies and mode shapes and compare results to the models used in design analysis. The final function performed in the ITF is routine aircraft maintenance. This includes preflight and post-flight instrumentation checks and the servicing of hydraulics, avionics, and engines necessary on any research aircraft. Aircraft are not merely moved to the ITF for automated testing purposes but are housed there throughout their flight test programs.

  5. Integrated Test Facility (ITF)

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The NASA-Dryden Integrated Test Facility (ITF), also known as the Walter C. Williams Research Aircraft Integration Facility (RAIF), provides an environment for conducting efficient and thorough testing of advanced, highly integrated research aircraft. Flight test confidence is greatly enhanced by the ability to qualify interactive aircraft systems in a controlled environment. In the ITF, each element of a flight vehicle can be regulated and monitored in real time as it interacts with the rest of the aircraft systems. Testing in the ITF is accomplished through automated techniques in which the research aircraft is interfaced to a high-fidelity real-time simulation. Electric and hydraulic power are also supplied, allowing all systems except the engines to function as if in flight. The testing process is controlled by an engineering workstation that sets up initial conditions for a test, initiates the test run, monitors its progress, and archives the data generated. The workstation is also capable of analyzing results of individual tests, comparing results of multiple tests, and producing reports. The computers used in the automated aircraft testing process are also capable of operating in a stand-alone mode with a simulation cockpit, complete with its own instruments and controls. Control law development and modification, aerodynamic, propulsion, guidance model qualification, and flight planning -- functions traditionally associated with real-time simulation -- can all be performed in this manner. The Remotely Augmented Vehicles (RAV) function, now located in the ITF, is a mainstay in the research techniques employed at Dryden. This function is used for tests that are too dangerous for direct human involvement or for which computational capacity does not exist onboard a research aircraft. RAV provides the researcher with a ground-based computer that is radio linked to the test aircraft during actual flight. The Ground Vibration Testing (GVT) system, formerly housed in the Thermostructural Laboratory, now also resides in the ITF. In preparing a research aircraft for flight testing, it is vital to measure its structural frequencies and mode shapes and compare results to the models used in design analysis. The final function performed in the ITF is routine aircraft maintenance. This includes preflight and post-flight instrumentation checks and the servicing of hydraulics, avionics, and engines necessary on any research aircraft. Aircraft are not merely moved to the ITF for automated testing purposes but are housed there throughout their flight test programs.

  6. Characteristics and significance of intergenic polyadenylated RNA transcription in Arabidopsis.

    PubMed

    Moghe, Gaurav D; Lehti-Shiu, Melissa D; Seddon, Alex E; Yin, Shan; Chen, Yani; Juntawong, Piyada; Brandizzi, Federica; Bailey-Serres, Julia; Shiu, Shin-Han

    2013-01-01

    The Arabidopsis (Arabidopsis thaliana) genome is the most well-annotated plant genome. However, transcriptome sequencing in Arabidopsis continues to suggest the presence of polyadenylated (polyA) transcripts originating from presumed intergenic regions. It is not clear whether these transcripts represent novel noncoding or protein-coding genes. To understand the nature of intergenic polyA transcription, we first assessed its abundance using multiple messenger RNA sequencing data sets. We found 6,545 intergenic transcribed fragments (ITFs) occupying 3.6% of Arabidopsis intergenic space. In contrast to transcribed fragments that map to protein-coding and RNA genes, most ITFs are significantly shorter, are expressed at significantly lower levels, and tend to be more data set specific. A surprisingly large number of ITFs (32.1%) may be protein coding based on evidence of translation. However, our results indicate that these "translated" ITFs tend to be close to and are likely associated with known genes. To investigate if ITFs are under selection and are functional, we assessed ITF conservation through cross-species as well as within-species comparisons. Our analysis reveals that 237 ITFs, including 49 with translation evidence, are under strong selective constraint and relatively distant from annotated features. These ITFs are likely parts of novel genes. However, the selective pressure imposed on most ITFs is similar to that of randomly selected, untranscribed intergenic sequences. Our findings indicate that despite the prevalence of ITFs, apart from the possibility of genomic contamination, many may be background or noisy transcripts derived from "junk" DNA, whose production may be inherent to the process of transcription and which, on rare occasions, may act as catalysts for the creation of novel genes.

  7. In Situ Fringe Projection Profilometry for Laser Power Bed Fusion Process

    NASA Astrophysics Data System (ADS)

    Zhang, Bin

    Additive manufacturing (AM) offers an industrial solution to produce parts with complex geometries and internal structures that conventional manufacturing techniques cannot produce. However, current metal additive process, particularly the laser powder bed fusion (LPBF) process, suffers from poor surface finish and various material defects which hinder its wide applications. One way to solve this problem is by adding in situ metrology sensor onto the machine chamber. Matured manufacturing processes are tightly monitored and controlled, and instrumentation advances are needed to realize this same advantage for metal additive process. This encourages us to develop an in situ fringe projection system for the LPBF process. The development of such a system and the measurement capability are demonstrated in this dissertation. We show that this system can measure various powder bed signatures including powder layer variations, the average height drop between fused metal and unfused powder, and the height variations on the fused surfaces. The ability to measure textured surface is also evaluated through the instrument transfer function (ITF). We analyze the mathematical model of the proposed fringe projection system, and prove the linearity of the system through simulations. A practical ITF measurement technique using a stepped surface is also demonstrated. The measurement results are compared with theoretical predictions generated through the ITF simulations.

  8. High resolution optical surface metrology with the slope measuring portable optical test system

    NASA Astrophysics Data System (ADS)

    Maldonado, Alejandro V.

    New optical designs strive to achieve extreme performance, and continually increase the complexity of prescribed optical shapes, which often require wide dynamic range and high resolution. SCOTS, or the Software Configurable Optical Test System, can measure a wide range of optical surfaces with high sensitivity using surface slope. This dissertation introduces a high resolution version of SCOTS called SPOTS, or the Slope measuring Portable Optical Test System. SPOTS improves the metrology of surface features on the order of sub-millimeter to decimeter spatial scales and nanometer to micrometer level height scales. Currently there is no optical surface metrology instrument with the same utility. SCOTS uses a computer controlled display (such as an LCD monitor) and camera to measure surface slopes over the entire surface of a mirror. SPOTS differs in that an additional lens is placed near the surface under test. A small prototype system is discussed in general, providing the support for the design of future SPOTS devices. Then the SCOTS instrument transfer function is addressed, which defines the way the system filters surface heights. Lastly, the calibration and performance of larger SPOTS device is analyzed with example measurements of the 8.4-m diameter aspheric Large Synoptic Survey Telescope's (LSST) primary mirror. In general optical systems have a transfer function, which filters data. In the case of optical imaging systems the instrument transfer function (ITF) follows the modulation transfer function (MTF), which causes a reduction of contrast as a function of increasing spatial frequency due to diffraction. In SCOTS, ITF is shown to decrease the measured height of surface features as their spatial frequency increases, and thus the SCOTS and SPOTS ITF is proportional to their camera system's MTF. Theory and simulations are supported by a SCOTS measurement of a test piece with a set of lithographically written sinusoidal surface topographies. In addition, an example of a simple inverse filtering technique is provided. The success of a small SPOTS proof of concept instrument paved the way for a new larger prototype system, which is intended to measure subaperture regions on large optical mirrors. On large optics, the prototype SPOTS is light weight and it rests on the surface being tested. One advantage of this SPOTS is stability over time in maintaining its calibration. Thus the optician can simply place SPOTS on the mirror, perform a simple alignment, collect measurement data, then pick the system up and repeat at a new location. The entire process takes approximately 5 to 10 minutes, of which 3 minutes is spent collecting data. SPOTS' simplicity of design, light weight, robustness, wide dynamic range, and high sensitivity make it a useful tool for optical shop use during the fabrication and testing process of large and small optics.

  9. An accurate registration technique for distorted images

    NASA Technical Reports Server (NTRS)

    Delapena, Michele; Shaw, Richard A.; Linde, Peter; Dravins, Dainis

    1990-01-01

    Accurate registration of International Ultraviolet Explorer (IUE) images is crucial because the variability of the geometrical distortions that are introduced by the SEC-Vidicon cameras ensures that raw science images are never perfectly aligned with the Intensity Transfer Functions (ITFs) (i.e., graded floodlamp exposures that are used to linearize and normalize the camera response). A technique for precisely registering IUE images which uses a cross correlation of the fixed pattern that exists in all raw IUE images is described.

  10. Walter C. Williams Research Aircraft Integration Facility (RAIF)

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The NASA-Dryden Integrated Test Facility (ITF), also known as the Walter C. Williams Research Aircraft Integration Facility (RAIF), provides an environment for conducting efficient and thorough testing of advanced, highly integrated research aircraft. Flight test confidence is greatly enhanced by the ability to qualify interactive aircraft systems in a controlled environment. In the ITF, each element of a flight vehicle can be regulated and monitored in real time as it interacts with the rest of the aircraft systems. Testing in the ITF is accomplished through automated techniques in which the research aircraft is interfaced to a high-fidelity real-time simulation. Electric and hydraulic power are also supplied, allowing all systems except the engines to function as if in flight. The testing process is controlled by an engineering workstation that sets up initial conditions for a test, initiates the test run, monitors its progress, and archives the data generated. The workstation is also capable of analyzing results of individual tests, comparing results of multiple tests, and producing reports. The computers used in the automated aircraft testing process are also capable of operating in a stand-alone mode with a simulation cockpit, complete with its own instruments and controls. Control law development and modification, aerodynamic, propulsion, guidance model qualification, and flight planning -- functions traditionally associated with real-time simulation -- can all be performed in this manner. The Remotely Augmented Vehicles (RAV) function, now located in the ITF, is a mainstay in the research techniques employed at Dryden. This function is used for tests that are too dangerous for direct human involvement or for which computational capacity does not exist onboard a research aircraft. RAV provides the researcher with a ground-based computer that is radio linked to the test aircraft during actual flight. The Ground Vibration Testing (GVT) system, formerly housed in the Thermostructural Laboratory, now also resides in the ITF. In preparing a research aircraft for flight testing, it is vital to measure its structural frequencies and mode shapes and compare results to the models used in design analysis. The final function performed in the ITF is routine aircraft maintenance. This includes preflight and post-flight instrumentation checks and the servicing of hydraulics, avionics, and engines necessary on any research aircraft. Aircraft are not merely moved to the ITF for automated testing purposes but are housed there throughout their flight test programs.

  11. Development and evaluation of the impulse transfer function technique

    NASA Technical Reports Server (NTRS)

    Mantus, M.

    1972-01-01

    The development of the test/analysis technique known as the impulse transfer function (ITF) method is discussed. This technique, when implemented with proper data processing systems, should become a valuable supplement to conventional dynamic testing and analysis procedures that will be used in the space shuttle development program. The method can relieve many of the problems associated with extensive and costly testing of the shuttle for transient loading conditions. In addition, the time history information derived from impulse testing has the potential for being used to determine modal data for the structure under investigation. The technique could be very useful in determining the time-varying modal characteristics of structures subjected to thermal transients, where conventional mode surveys are difficult to perform.

  12. The Oral Histone Deacetylase Inhibitor ITF2357 Reduces Cytokines and Protects Islet β Cells In Vivo and In Vitro

    PubMed Central

    Lewis, Eli C; Blaabjerg, Lykke; Størling, Joachim; Ronn, Sif G; Mascagni, Paolo; Dinarello, Charles A; Mandrup-Poulsen, Thomas

    2011-01-01

    In type 1 diabetes, inflammatory and immunocompetent cells enter the islet and produce proinflammatory cytokines such as interleukin-1β (IL-1β), IL-12, tumor necrosis factor-α (TNFα) and interferon-γ (IFNγ); each contribute to β-cell destruction, mediated in part by nitric oxide. Inhibitors of histone deacetylases (HDAC) are used commonly in humans but also possess antiinflammatory and cytokine-suppressing properties. Here we show that oral administration of the HDAC inhibitor ITF2357 to mice normalized streptozotocin (STZ)-induced hyperglycemia at the clinically relevant doses of 1.25–2.5 mg/kg. Serum nitrite levels returned to nondiabetic values, islet function improved and glucose clearance increased from 14% (STZ) to 50% (STZ + ITF2357). In vitro, at 25 and 250 nmol/L, ITF2357 increased islet cell viability, enhanced insulin secretion, inhibited MIP-1α and MIP-2 release, reduced nitric oxide production and decreased apoptosis rates from 14.3% (vehicle) to 2.6% (ITF2357). Inducible nitric oxide synthase (iNOS) levels decreased in association with reduced islet-derived nitrite levels. In peritoneal macrophages and splenocytes, ITF2357 inhibited the production of nitrite, as well as that of TNFα and IFNγ at an IC50 of 25–50 nmol/L. In the insulin-producing INS cells challenged with the combination of IL-1β plus IFNγ, apoptosis was reduced by 50% (P < 0.01). Thus at clinically relevant doses, the orally active HDAC inhibitor ITF2357 favors β-cell survival during inflammatory conditions. PMID:21193899

  13. Determination of acoustical transfer functions using an impulse method

    NASA Astrophysics Data System (ADS)

    MacPherson, J.

    1985-02-01

    The Transfer Function of a system may be defined as the relationship of the output response to the input of a system. Whilst recent advances in digital processing systems have enabled Impulse Transfer Functions to be determined by computation of the Fast Fourier Transform, there has been little work done in applying these techniques to room acoustics. Acoustical Transfer Functions have been determined for auditoria, using an impulse method. The technique is based on the computation of the Fast Fourier Transform (FFT) of a non-ideal impulsive source, both at the source and at the receiver point. The Impulse Transfer Function (ITF) is obtained by dividing the FFT at the receiver position by the FFT of the source. This quantity is presented both as linear frequency scale plots and also as synthesized one-third octave band data. The technique enables a considerable quantity of data to be obtained from a small number of impulsive signals recorded in the field, thereby minimizing the time and effort required on site. As the characteristics of the source are taken into account in the calculation, the choice of impulsive source is non-critical. The digital analysis equipment required for the analysis is readily available commercially.

  14. The Indonesian throughflow, its variability and centennial change

    NASA Astrophysics Data System (ADS)

    Feng, Ming; Zhang, Ningning; Liu, Qinyan; Wijffels, Susan

    2018-12-01

    The Indonesian Throughflow (ITF) is an important component of the upper cell of the global overturning circulation that provides a low-latitude pathway for warm, fresh waters from the Pacific to enter the Indian Ocean. Variability and changes of the ITF have significant impacts on Indo-Pacific oceanography and global climate. In this paper, the observed features of the ITF and its interannual to decadal variability are reviewed, and processes that influence the centennial change of the ITF under the influence of the global warming are discussed. The ITF flows across a region that comprises the intersection of two ocean waveguides—those of the equatorial Pacific and equatorial Indian Ocean. The ITF geostrophic transport is stronger during La Niñas and weaker during El Niños due to the influences through the Pacific waveguide. The Indian Ocean wind variability associated with the Indian Ocean Dipole (IOD) in many years offsets the Pacific ENSO influences on the ITF geostrophic transport during the developing and mature phases of El Niño and La Niña through the Indian Ocean waveguide, due to the co-varying IOD variability with ENSO. Decadal and multi-decadal changes of the geostrophic ITF transport have been revealed: there was a weakening change from the mid-1970s climate regime shift followed by a strengthening trend of about 1Sv every 10 year during 1984-2013. These decadal changes are mostly due to the ITF responses to decadal variations of the trade winds in the Pacific. Thus, Godfrey's Island Rule, as well as other ITF proxies, appears to be able to quantify decadal variations of the ITF. Climate models project a weakening trend of the ITF under the global warming. Both climate models and downscaled ocean model show that this ITF weakening is not directly associated with the changes of the trade winds in the Pacific into the future, and the reduction of deep upwelling in the Pacific basin is mainly responsible for the ITF weakening. There is a need to amend the Island Rule to take into account the contributions from the overturning circulation which the current ITF proxies fail to capture. The implication of a weakened ITF on the Indo-Pacific Ocean circulation still needs to be assessed.

  15. Tracing artificial trans fat in popular foods in Europe: a market basket investigation.

    PubMed

    Stender, Steen; Astrup, Arne; Dyerberg, Jørn

    2014-05-20

    To minimise the intake of industrial artificial trans fat (I-TF), nearly all European countries rely on food producers to voluntarily reduce the I-TF content in food. The objective of this study was to investigate the effect of this strategy on I-TF content in prepackaged biscuits/cakes/wafers in 2012-2013 in 20 European countries. The I-TF content was assessed in a market basket investigation. Three large supermarkets were visited in each capital, and in some countries, three additional ethnic shops were included. A total of 598 samples of biscuits/cakes/wafers with 'partially hydrogenated vegetable fat' or a similar term high on the list of ingredients were analysed, 312 products had more than 2% of fat as I-TF, exceeding the legislatively determined I-TF limit in Austria and Denmark; the mean (SD) was 19 (7)%. In seven countries, no I-TF was found, whereas nine predominantly Eastern European countries had products with very high I-TF content, and the remaining four countries had intermediate levels. Of the five countries that were examined using the same procedure as in 2006, three had unchanged I-TF levels in 2013, and two had lower levels. The 18 small ethnic shops examined in six Western European countries sold 83 products. The mean (SD) was 23 (12)% of the fat as I-TF, all imported from countries in Balkan. In Sweden, this type of food imported from Balkan was also available in large supermarkets. The findings suggest that subgroups of the population in many countries in Europe still consume I-TF in amounts that increase their risk of coronary heart disease. Under current European Union (EU) legislation, the sale of products containing I-TF is legal but conflicts with the WHO recommendation to minimise the intake of I-TF. An EU-legislative limit on I-TF content in foods is expected to be an effective strategy to achieve this goal. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  16. Indonesian Throughflow variability over the last glacial cycle (Invited)

    NASA Astrophysics Data System (ADS)

    Holbourn, A. E.; Kuhnt, W.; Regenberg, M.; Xu, J.; Hendrizan, M.; Schröder, J.

    2013-12-01

    The transfer of surface and intermediate waters from the Pacific Ocean to the Indian Ocean through the Indonesian archipelago (Indonesian Throughflow: ITF) strongly influences the heat and freshwater budgets of tropical water masses, in turn affecting global climate. Key areas for monitoring past ITF variations through this critical gateway are the narrow passages through the Makassar Strait and Flores Sea and the main outflow area within the Timor Sea. Here, we integrate high-resolution sea surface temperature and salinity reconstructions (based on paired planktic foraminiferal Mg/Ca and δ18O) with X-ray fluorescence runoff data and benthic isotopes from marine sediment cores retrieved in these regions during several cruises with RV'Sonne' and RV'Marion Dufresne'. Our results show that high latitude climate variability strongly influenced ITF intensity on millennial to centennial timescales as well as on longer glacial-interglacial timescales. Marked declines in ITF strength occurred during Heinrich events and the Younger Dryas, most likely related to slowdown of the global thermohaline circulation during colder northern hemisphere climate spells, when deep water production decreased and the deep ocean became more stratified. Additionally, the surface component of the ITF strongly reflects regional windstress and rainfall patterns, and thus the spatial extent and intensity of the tropical convection over the Indonesian archipelago. Our runoff and salinity estimates reveal that the development of the tropical convection was intricately linked to the latitudinal migration of the Inter Tropical Convergence Zone (ITCZ). In particular, our data show that the Australian monsoon intensified during the major deglacial atmospheric CO2 rise through the Younger Dryas and earliest Holocene (12.9-10 ka). This massive intensification of the Australian monsoon coincided with a southward shift of the ITCZ, linked to southern hemisphere warming and enhanced greenhouse forcing over the Australian continent. However, the development of the monsoon was asynchronous over the region, which we relate to changes in landmass exposure during deglacial sea-level rise. Thus, we find that sea-level exerted a major control on ITF properties through the last glacial termination by altering gateway configuration and precipitation-evaporation budgets over the Indonesian archipelago.

  17. EMP-002a Phase Shift through the Ionosphere

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Soltz, R.; Simons, D.; Fenimore, E.

    2015-10-20

    In this note we review the derivation and use of the Ionospheric Transfer Function (ITF) in the DIO- RAMA model to calculate the propagation of a broad band ElectroMagnetic Pulse (EMP) through the Ionosphere in the limit of geometric optics. This note is intended to resolve a misunderstanding between the NDS VVA and EMP modeling teams regarding the appropriate use of the phase and group velocities in DIORAMA. The di erent approaches are documented in EMP-002 note, \\Phase vs. Group" [1], generated by the LLNL DIORAMA VVA team, and the subsequent response from the DIORAMA EMP modeling team' [2].

  18. Labour analgesia with intrathecal fentanyl decreases maternal stress.

    PubMed

    Cascio, M; Pygon, B; Bernett, C; Ramanathan, S

    1997-06-01

    Lumbar epidural analgesia (LEA) decreases maternal stress as measured by maternal circulating plasma catecholamine concentrations. Intrathecal fentanyl (ITF) provides effective labour analgesia but its effect on maternal epinephrine (Epi) and norepinephrine (NE) concentrations is not known. This study assesses whether ITF reduces maternal stress in the same manner as conventional LEA. Twenty-four healthy women in active labour received either 25 micrograms ITF (n = 12) or epidural lidocaine 1.5% (n = 12) for analgesia. Venous blood samples were collected before anaesthesia and at five minute intervals for 30 min following anaesthesia for the measurement of plasma Epi and NE by high performance liquid chromatography. Maternal blood pressure (BP), heart rate (HR), visual analog scores (VAS) to pain and pruritus were recorded at the same time. Both ITF and LEA decreased pain VAS scores, maternal BP, and plasma Epi concentrations with only minimal effects on plasma NE concentrations. Intrathecal fentanyl (ITF) and LEA reduced plasma epi to a similar extent, with ITF reducing the levels slightly faster than LEA. Intrathecal fentanyl(ITF) and LEA reduced plasma Epi concentrations by 52% and 51%, respectively (P value < 0.01). We conclude that ITF is as effective as LEA in producing pain relief in the labouring patient. Intrathecal Fentanyl (ITF) is also capable of reducing maternal plasma epinephrine concentration, thus avoiding the possibly deleterious side effects of excess amounts of this catecholamine during labour.

  19. Histone deacetylase inhibitor ITF2357 leads to apoptosis and enhances doxorubicin cytotoxicity in preclinical models of human sarcoma.

    PubMed

    Di Martile, Marta; Desideri, Marianna; Tupone, Maria Grazia; Buglioni, Simonetta; Antoniani, Barbara; Mastroiorio, Carlotta; Falcioni, Rita; Ferraresi, Virginia; Baldini, Nicola; Biagini, Roberto; Milella, Michele; Trisciuoglio, Daniela; Del Bufalo, Donatella

    2018-02-23

    Sarcomas are rare tumors with generally poor prognosis, for which current therapies have shown limited efficacy. Histone deacetylase inhibitors (HDACi) are emerging anti-tumor agents; however, little is known about their effect in sarcomas. By using established and patient-derived sarcoma cells with different subtypes, we showed that the pan-HDACi, ITF2357, potently inhibited in vitro survival in a p53-independent manner. ITF2357-mediated cell death implied the activation of mitochondrial apoptosis, as attested by induction of pro-apoptotic BH3-only proteins and a caspases-dependent mechanism. ITF2357 also induced autophagy, which protected sarcoma cells from apoptotic cell death. ITF2357 activated forkhead box (FOXO) 1 and 3a transcription factors and their downstream target genes, however, silencing of both FOXO1 and 3a did not protect sarcoma cells against ITF2357-induced apoptosis and upregulated FOXO4 and 6. Notably, ITF2357 synergized with Doxorubicin to induce cell death of established and patient-derived sarcoma cells. Furthermore, combination treatment strongly impaired xenograft tumor growth in vivo, when compared to single treatments, suggesting that combination of ITF2357 with Doxorubicin has the potential to enhance sensitization in different preclinical models of sarcoma. Overall, our study highlights the therapeutic potential of ITF2357, alone or in rational combination therapies, for bone and soft tissue sarcomas management.

  20. The NASA integrated test facility and its impact on flight research

    NASA Technical Reports Server (NTRS)

    Mackall, D. A.; Pickett, M. D.; Schilling, L. J.; Wagner, C. A.

    1988-01-01

    The Integrated Test Facility (ITF), being built at NASA Ames-Dryden Flight Research Facility, will provide new test capabilities for emerging research aircraft. An overview of the ITF and the challenges being addressed by this unique facility are outlined. The current ITF capabilities, being developed with the X-29 Forward Swept Wing Program, are discussed along with future ITF activities.

  1. Improvement of hypothyroidism after laparoscopic Roux-en-Y gastric bypass for morbid obesity.

    PubMed

    Raftopoulos, Yannis; Gagné, Daniel J; Papasavas, Pavlos; Hayetian, Fernando; Maurer, Julie; Bononi, Patricia; Caushaj, Philip F

    2004-04-01

    Laparoscopic Roux-en-Y gastric bypass (LRYGBP) has been very effective in managing a broad range of morbid obesity-related co-morbidities. We report a beneficial effect of LRYGBP that has not been previously observed. Between December 1999 and September 2002, 224 patients underwent LRYGBP. Preoperative assessment for hypothyroidism and follow-up data were prospectively collected in our database. Improved thyroid function (ITF) or unchanged thyroid function (UTF) was determined by comparison of preoperative and postoperative thyroxine requirements. 23 of 224 patients (10.3%) were treated preoperatively for hypothyroidism. During a median follow-up of 17 months, hypothyroidism was improved in 10/23 patients (43.5%). 2 patients had complete resolution, and the remaining 8 had reduction (14%-50%) of their thyroxine requirements. ITF occurred at a mean follow-up of 8.9 months and at a mean excess weight loss (EWL) of 57%. 6 of the 8 patients (75%) with ITF >or= 25% had EWL >90% at last follow-up, compared to 1 out of 15 patients (6.6%) with UTF or <25% improvement (P =0.001). Comparison of patients with ITF and UTF over time during a 20-month follow-up, showed no significant difference in mean body mass index (BMI) and mean percentage of EWL. Improvement of hypothyroidism may be an additional benefit of bariatric surgery that has not been previously reported. Reduction of thyroxine requirements is most likely the result of the decrease in the BMI.

  2. The Indonesian Throughflow (ITF) and its impacts on the Indian Ocean during the global warming slowdown period

    NASA Astrophysics Data System (ADS)

    Makarim, S.; Liu, Z.; Yu, W.; Yan, X.; Sprintall, J.

    2016-12-01

    The global warming slowdown indicated by a slower warming rate at the surface layer accompanied by stronger heat transport into the deeper layers has been explored in the Indian Ocean. Although the mechanisms of the global warming slowdown are still under warm debate, some clues have been recognized that decadal La Nina like-pattern induced decadal cooling in the Pacific Ocean and generated an increase of the Indonesian Throughflow (ITF) transport in 2004-2010. However, how the ITF spreading to the interior of the Indian Ocean and the impact of ITF changes on the Indian Ocean, in particular its water mass transformation and current system are still unknown. To this end, we analyzed thermohaline structure and current system at different depths in the Indian Ocean both during and just before the global warming slowdown period using the ORAS4 and ARGO dataset. Here, we found the new edge of ITF at off Sumatra presumably as northward deflection of ITF Lombok Strait, and The Monsoon Onset Monitoring and Social Ecology Impact (MOMSEI) and Java Upwelling Variation Observation (JUVO) dataset confirmed this evident. An isopycnal mixing method initially proposed by Du et al. (2013) is adopted to quantify the spreading of ITF water in the Indian Ocean, and therefore the impacts of ITF changes on the variation of the Agulhas Current, Leuween Current, Bay of Bengal Water. This study also prevailed the fresher salinity in the Indian Ocean during the slowdown warming period were not only contributed by stronger transport of the ITF, but also by freshening Arabian Sea and infiltrating Antartic Intermediate Water (AAIW).

  3. Closed-Circuit Educational Television (ITFS) in Northeastern California: The 33,000 Square Mile Campus.

    ERIC Educational Resources Information Center

    Meuter, Ralph F.; And Others

    This paper describes the Instructional Television Fixed Service (ITFS) program, a closed-circuit educational television system in which classes originating on the California State University, Chico (CSUC) campus are simultaneously broadcast live to various ITFS sites within Northeastern California. Following an introduction, the first section…

  4. The Indonesian Throughflow: Oceanographic responses to Holocene changes in the mean Pacific state

    NASA Astrophysics Data System (ADS)

    Jacobel, A. W.; Oppo, D.; Eglinton, T. I.; Gibbons, F. T.; Montlucon, D.; Rosenthal, Y.; Linsley, B. K.

    2009-12-01

    The Indonesian Throughflow (ITF), which transfers upper ocean waters from the Pacific to the Indian Ocean, plays an essential role in global ocean circulation and tropical climate regulation. The flow and mixing regimes of the ITF are affected by changes in temperature, winds and upwelling caused by the Asian Monsoon/Intertropical Convergence Zone (AM/ITCZ) and interannual variations in El Niño (EN). Because the ITF is located in the Western Pacific Warm Pool, an area from which the atmosphere derives a large portion of its heat and water budget, changes in the ITF have the potential to perturb atmospheric circulation globally. Despite the importance of this region to global climate, changes in the ocean-atmosphere climate phenomenon affecting the ITF are still poorly understood. Our study used organic geochemical proxies for upwelling in the Makassar Strait to investigate Holocene oceanographic changes in the ITF in response to EN and the AM/ITCZ. A core-top biomarker survey was performed on multi-core samples from the Makassar Strait and surrounding areas. Concentrations of cholesterol (an indicator of integrated primary productivity) were determined by Gas Chromatography-Mass Spectrometry and were then compared with maps of regional July-August SST and determined to accurately reflect regional upwelling. Based on the findings of the core-top survey, a down-core biomarker record was generated from core BJ8-03-70 GGC taken from the West Sulawesi Margin in the Eastern Makassar Strait, an area that experiences seasonal upwelling associated with the boreal summer Asian monsoon. Cholesterol data show a trend towards increasing concentrations (upwelling or thermocline shoaling) in the late Holocene with a considerable increase approximately 6,000 years before present. Additionally, upwelling intensity appears to show more centennial-millennial variability during the late Holocene. Evidence that the summer monsoon has decreased in strength over the course of the Holocene (e.g. Wang et al., 2005) suggests that the increase in cholesterol is not a response to an increase in monsoon-driven upwelling. Because a shallower thermocline is associated with weak trade winds (El Niño-like conditions in the modern ocean), we interpret these results to represent a mid Holocene transition to a more El Niño-like mean Pacific state. This interpretation is consistent with previous evidence (Moy et al., 2002 and Conroy et al., 2008, yet the timing and reason for this transition is not well constrained. Further work should seek to develop a higher-resolution, multi-proxy dataset to explore and explain this change.

  5. The role of the Indonesian Throughflow in equatorial Pacific thermocline ventilation

    NASA Astrophysics Data System (ADS)

    Rodgers, Keith B.; Cane, Mark A.; Naik, Naomi H.; Schrag, Daniel P.

    1999-09-01

    The role of the Indonesian Throughflow (ITF) in the thermocline circulation of the low-latitude Pacific Ocean is explored using a high-resolution primitive equation ocean circulation model. Seasonally forced runs for a domain with an open Indonesian passage are compared with seasonally forced runs for a closed Pacific domain. Three cases are considered: one with no throughflow, one with 10 Sv of imposed ITF transport, and one with 20 Sv of ITF transport. Two idealized tracers, one that tags northern component subtropical water and another that tags southern component subtropical water, are used to diagnose the mixing ratio of northern and southern component waters in the equatorial thermocline. It is found that the mixing ratio of north/south component waters in the equatorial thermocline is highly sensitive to whether the model accounts for an ITF. Without an ITF, the source of equatorial undercurrent water is primarily of North Pacific origin, with the ratio of northern to southern component water being approximately 2.75 to 1. The ratio of northern to southern component water in the Equatorial Undercurrent with 10 Sv of ITF is approximately 1.4 to 1, and the ratio with 20 Sv of imposed ITF is 1 to 1.25. Estimates from data suggest a mean mixing ratio of northern to southern component water of less than 1 to 1. Assuming that the mixing ratio changes approximately linearly as the ITF transport varies between 10 and 20 Sv, an approximate balance between northern and southern component water is reached when the ITF transport is approximately 16 Sv. It is also shown that for the isopycnal surfaces within the core of the equatorial undercurrent, a 2°C temperature front exists across the equator in the western equatorial Pacific, beneath the warm pool. The implications of the model results and the temperature data for the heat budget of the equatorial Pacific are considered.

  6. Iron-tannin-framework complex modified PES ultrafiltration membranes with enhanced filtration performance and fouling resistance.

    PubMed

    Fang, Xiaofeng; Li, Jiansheng; Li, Xin; Pan, Shunlong; Sun, Xiuyun; Shen, Jinyou; Han, Weiqing; Wang, Lianjun; Van der Bruggen, Bart

    2017-11-01

    In this work, an iron-tannin-framework (ITF) complex was introduced to a poly (ether sulfone) (PES) casting solution as a hydrophilic additive to fabricate ITF/PES ultrafiltration (UF) membranes via non-solvent-induced phase separation (NIPS). The structure and performance of the PES membranes with ITF concentrations ranging from 0 to 0.9wt.% were systematically investigated by scanning electron microscopy, water contact angle, permeability, protein rejection and fouling resistance measurements. The results indicate that the pore structure and surface properties of PES UF membranes can be regulated by incorporating the ITF complex. Compared with classical PES membranes, ITF/PES membranes were found to have an increased hydrophilicity and porosity and reduced surface pore size. Importantly, a simultaneous enhancement of permeability and separation performance was observed for the blend membranes, which indicates that the introduction of the ITF complex can break through the trade-off between permeability and selectivity of UF membranes.When the ITF content was 0.3wt.%, the permeability reached a maximum of 319.4(L/m 2 h) at 0.1MPa, which is 1.6 times higher than that of the classical PES membrane. Furthermore, the BSA rejection increased from 25.9% for the PES membrane to 95.9% for the enhanced membrane. In addition, the same membrane showed an improved fouling resistance (higher flux recovery and lower adhesion force) and stable hydrophilicity (unchanged after incubation in deionized water for 30days). The simple, green and cost-effective preparation process and the outstanding filtration performance highlight the potential of ITF/PES membranes for practical applications. Copyright © 2017 Elsevier Inc. All rights reserved.

  7. Targeting the gut microbiota with inulin-type fructans: preclinical demonstration of a novel approach in the management of endothelial dysfunction.

    PubMed

    Catry, Emilie; Bindels, Laure B; Tailleux, Anne; Lestavel, Sophie; Neyrinck, Audrey M; Goossens, Jean-François; Lobysheva, Irina; Plovier, Hubert; Essaghir, Ahmed; Demoulin, Jean-Baptiste; Bouzin, Caroline; Pachikian, Barbara D; Cani, Patrice D; Staels, Bart; Dessy, Chantal; Delzenne, Nathalie M

    2018-02-01

    To investigate the beneficial role of prebiotics on endothelial dysfunction, an early key marker of cardiovascular diseases, in an original mouse model linking steatosis and endothelial dysfunction. We examined the contribution of the gut microbiota to vascular dysfunction observed in apolipoprotein E knockout (Apoe -/- ) mice fed an n-3 polyunsaturated fatty acid (PUFA)-depleted diet for 12 weeks with or without inulin-type fructans (ITFs) supplementation for the last 15 days. Mesenteric and carotid arteries were isolated to evaluate endothelium-dependent relaxation ex vivo. Caecal microbiota composition (Illumina Sequencing of the 16S rRNA gene) and key pathways/mediators involved in the control of vascular function, including bile acid (BA) profiling, gut and liver key gene expression, nitric oxide and gut hormones production were also assessed. ITF supplementation totally reverses endothelial dysfunction in mesenteric and carotid arteries of n-3 PUFA-depleted Apoe -/- mice via activation of the nitric oxide (NO) synthase/NO pathway. Gut microbiota changes induced by prebiotic treatment consist in increased NO-producing bacteria, replenishment of abundance in Akkermansia and decreased abundance in bacterial taxa involved in secondary BA synthesis. Changes in gut and liver gene expression also occur upon ITFs suggesting increased glucagon-like peptide 1 production and BA turnover as drivers of endothelium function preservation. We demonstrate for the first time that ITF improve endothelial dysfunction, implicating a short-term adaptation of both gut microbiota and key gut peptides. If confirmed in humans, prebiotics could be proposed as a novel approach in the prevention of metabolic disorders-related cardiovascular diseases. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  8. Sensitivity and specificity of intrathecal fluorescein and white light excitation for detecting intraoperative cerebrospinal fluid leak in endoscopic skull base surgery: a prospective study.

    PubMed

    Raza, Shaan M; Banu, Matei A; Donaldson, Angela; Patel, Kunal S; Anand, Vijay K; Schwartz, Theodore H

    2016-03-01

    The intraoperative detection of CSF leaks during endonasal endoscopic skull base surgery is critical to preventing postoperative CSF leaks. Intrathecal fluorescein (ITF) has been used at varying doses to aid in the detection of intraoperative CSF leaks. However, the sensitivity and specificity of ITF at certain dosages is unknown. A prospective database of all endoscopic endonasal procedures was reviewed. All patients received 25 mg ITF diluted in 10 ml CSF and were pretreated with dexamethasone and Benadryl. Immediately after surgery, the operating surgeon prospectively noted if there was an intraoperative CSF leak and fluorescein was identified. The sensitivity, specificity, and positive and negative predictive power of ITF for detecting intraoperative CSF leak were calculated. Factors correlating with postoperative CSF leak were determined. Of 419 patients, 35.8% of patients did not show a CSF leak. Fluorescein-tinted CSF (true positive) was noted in 59.7% of patients and 0 false positives were encountered. CSF without fluorescein staining (false negative) was noted in 4.5% of patients. The sensitivity and specificity of ITF were 92.9% and 100%, respectively. The negative and positive predictive values were 88.8% and 100%, respectively. Postoperative CSF leaks only occurred in true positives at a rate of 2.8%. ITF is extremely specific and very sensitive for detecting intraoperative CSF leaks. Although false negatives can occur, these patients do not appear to be at risk for postoperative CSF leak. The use of ITF may help surgeons prevent postoperative CSF leaks by intraoperatively detecting and confirming a watertight repair.

  9. Effects of dietary lipid composition and inulin-type fructans on mineral bioavailability in growing rats.

    PubMed

    Lobo, Alexandre Rodrigues; Filho, Jorge Mancini; Alvares, Eliana Parisi; Cocato, Maria Lucia; Colli, Célia

    2009-02-01

    This study reports the effects of feeding with a combination of inulin-type fructans (ITF) and fish oil (FO) on mineral absorption and bioavailability as part of a semipurified diet offered to rats. Male Wistar rats (n = 24) were fed a 15% lipid diet (soybean oil [SO] or a 1:0.3 fish:soybean oil mixture [FSO]) and diets containing the same sources of lipids supplemented with 10% ITF (Raftilose Synergy 1) ad libitum for 15 d. Feces and urine were collected for mineral analyses during the last 5 d of the test period. Fatty acid composition was determined in liver and cecal mucosa homogenates. Liver and bone mineral analyses were performed by atomic absorption spectrophotometry. Bone biomechanical analyses were evaluated by a 3-point bending test. Compared with the controls, ITF-fed rats had enlarged ceca and a significant decrease in cecal content pH (P < 0.001). The apparent mineral absorption was improved in these rats, and this effect was enhanced by dietary combination with FO for all minerals except for magnesium. Addition of ITF to the diet resulted in higher bone mineral content (calcium and zinc) and bone strength, but increased bone mineral content was only statistically significant in FO-fed animals. A decrease in liver iron stores (P = 0.015) was observed in rats fed FO, considering that ITF consumption returned to levels comparable to the SO control group. These findings confirm the positive influence of ITF on mineral bioavailability, which was potentiated by addition of FO to the diet.

  10. Expression of intestinal trefoil factor, proliferating cell nuclear antigen and histological changes in intestine of rats after intrauterine asphyxia

    PubMed Central

    Xu, Ling-Fen; Li, Jun; Sun, Mei; Sun, Hong-Wei

    2005-01-01

    AIM: To study the expressions of intestinal trefoil factor (ITF) and proliferating cell nuclear antigen (PCNA) and histologic changes in intestine, to investigate the relationship between ITF and intestinal damage and repair after intrauterine hypoxia so as to understand the mechanism of intestinal injury and to find a new way to prevent and treat gastrointestinal diseases. METHODS: Wistar rats, pregnant for 21 d, were used to establish animal models of intrauterine asphyxia by clamping one side of vessels supplying blood to uterus for 20 min, another side was regarded as sham operation group. Intestinal tissues were taken away at 0, 24, 48 and 72 h after birth and stored in different styles. ITF mRNA was detected by RT-PCR. PCNA expression was measured by immunohistochemistry. Intestinal tissues were studied histologically by HE staining in order to observe the areas and degree of injury and to value the intestinal mucosa injury index (IMDI). RESULTS: ITF mRNA appeared in full-term rats and increased with age. After ischemia, ITF mRNA was decreased to the minimum (0.59±0.032) 24 h after birth, then began to increase higher after 72 h than it was in the control group (P<0.01). PCNA positive staining located in goblet cell nuclei. The PCNA level had a remarkable decline (53.29±1.97) 48 h after ischemia. Structure changes were obvious in 48-h group, IMDI (3.40±0.16) was significantly increased. Correlation analyses showed that IMDI had a negative correlation with ITF mRNA and PCNA (r = -0.543, P<0.05; r = -0.794, P<0.01, respectively). CONCLUSION: Intrauterine ischemia can result in an early decrease of ITF mRNA expression. ITF and PCNA may play an important role in the damage and repair of intestinal mucosa. PMID:15818741

  11. Complementary Mechanisms for Degradation of Inulin-Type Fructans and Arabinoxylan Oligosaccharides among Bifidobacterial Strains Suggest Bacterial Cooperation.

    PubMed

    Rivière, Audrey; Selak, Marija; Geirnaert, Annelies; Van den Abbeele, Pieter; De Vuyst, Luc

    2018-05-01

    Inulin-type fructans (ITF) and arabinoxylan oligosaccharides (AXOS) are broken down to different extents by various bifidobacterial strains present in the human colon. To date, phenotypic heterogeneity in the consumption of these complex oligosaccharides at the strain level remains poorly studied. To examine mechanistic variations in ITF and AXOS constituent preferences present in one individual, ITF and AXOS consumption by bifidobacterial strains isolated from the simulator of the human intestinal microbial ecosystem (SHIME) after inoculation with feces from one healthy individual was investigated. Among the 18 strains identified, four species-independent clusters displaying different ITF and AXOS degradation mechanisms and preferences were found. Bifidobacterium bifidum B46 showed limited growth on all substrates, whereas B. longum B24 and B. longum B18 could grow better on short-chain-length fractions of fructooligosaccharides (FOS) than on fructose. B. longum B24 could cleave arabinose substituents of AXOS extracellularly, without using the AXOS-derived xylose backbones, whereas B. longum B18 was able to consume oligosaccharides (up to xylotetraose) preferentially and consumed AXOS to a limited extent. B. adolescentis B72 degraded all fractions of FOS simultaneously, partially degraded inulin, and could use xylose backbones longer than xylotetraose extracellularly. The strain-specific degradation mechanisms were suggested to be complementary and indicated resource partitioning. Specialization in the degradation of complex carbohydrates by bifidobacteria present on the individual level could have in vivo implications for the successful implementation of ITF and AXOS, aiming at bifidogenic and/or butyrogenic effects. Finally, this work shows the importance of taking microbial strain-level differences into account in gut microbiota research. IMPORTANCE It is well known that bifidobacteria degrade undigestible complex polysaccharides, such as ITF and AXOS, in the human colon. However, this process has never been studied for strains coexisting in the same individual. To examine strain-dependent mechanistic variations in ITF and AXOS constituent preferences present in one individual, ITF and AXOS consumption by bifidobacterial strains isolated from the SHIME after inoculation with feces from one healthy individual was investigated. Among the 18 bifidobacterial strains identified, four species-independent clusters displaying different ITF and AXOS degradation mechanisms and preferences were found, indicating that such strains can coexist in the human colon. Such specialization in the degradation of complex carbohydrates by bifidobacteria present on the individual level could have in vivo implications for the successful implementation of ITF and AXOS, aiming at bifidogenic and/or butyrogenic effects. Copyright © 2018 American Society for Microbiology.

  12. Observed strengthening of interbasin exchange via the Indonesian seas due to rainfall intensification

    PubMed Central

    Sprintall, Janet

    2017-01-01

    Abstract A proxy of the Indonesian Throughflow (ITF) transport, developed using in situ hydrographic measurements along with assimilations, shows a significant strengthening trend during the past decade. This trend is due to a freshening and subsequent increase in the halosteric component of the ITF transport associated with enhanced rainfall over the Maritime Continent over the same period. The strengthening of the ITF transport leads to a significant change in heat and freshwater exchange between the Pacific and Indian Oceans and contributes to the warming and freshening of the eastern Indian Ocean. The combined effect of the ITF transport of mass and freshwater along with tropical rainfall plays a very important role in the climate system. PMID:28405053

  13. Role of the Indonesian Throughflow in controlling regional mean climate and rainfall variability

    NASA Astrophysics Data System (ADS)

    England, Matthew H.; Santoso, Agus; Phipps, Steven; Ummenhofer, Caroline

    2017-04-01

    The role of the Indonesian Throughflow (ITF) in controlling regional mean climate and rainfall is examined using a coupled ocean-atmosphere general circulation model. Experiments employing both a closed and open ITF are equilibrated to steady state and then 200 years of natural climatic variability is assessed within each model run, with a particular focus on the Indian Ocean region. Opening of the ITF results in a mean Pacific-to-Indian throughflow of 21 Sv (1 Sv = 106 m3 sec-1), which advects warm west Pacific waters into the east Indian Ocean. This warm signature is propagated westward by the mean ocean flow, however it never reaches the west Indian Ocean, as an ocean-atmosphere feedback in the tropics generates a weakened trade wind field that is reminiscent of the negative phase of the Indian Ocean Dipole (IOD). This is in marked contrast to the Indian Ocean response to an open ITF when examined in ocean-only model experiments; which sees a strengthening of both the Indian Ocean South Equatorial Current and the Agulhas Current. The coupled feedback in contrast leads to cooler conditions over the west Indian Ocean, and an anomalous zonal atmospheric pressure gradient that enhances the advection of warm moist air toward south Asia and Australia. This leaves the African continent significantly drier, and much of Australia and southern Asia significantly wetter, in response to the opening of the ITF. Given the substantial interannual variability that the ITF exhibits in the present-day climate system, and the restriction of the ITF gateway in past climate eras, this could have important implications for understanding past and present regional rainfall patterns around the Indian Ocean and over neighbouring land-masses.

  14. Modulation of epidermal growth factor effects on epithelial ion transport by intestinal trefoil factor.

    PubMed Central

    Chinery, R.; Cox, H. M.

    1995-01-01

    1. The direct epithelial effects of epidermal growth factor (EGF) and its modulation by intestinal trefoil factor (ITF) have been studied in a human colonic adenocarcinoma cell line called Colony-29 (Col-29). 2. When grown in culture as confluent monolayers and voltage-clamped in Ussing chambers, these epithelia responded with an increase in short circuit current (SCC) to basolateral as well as to apically applied EGF although the latter responses (at 10 nM) were only 25% of those observed following basolateral peptide. 3. Recombinant rat ITF (added to the basolateral surface) did not alter basal SCC levels, but it did enhance the electrogenic effects of basolateral EGF. The EC50 values for EGF-induced ion transport were 0.25 nM in control, and 0.26 nM in ITF pretreated Col-29 epithelia. A significant increase in the size of EGF responses (0.1 nM-10 nM) was observed in the presence of 10 nM ITF and the half-maximal concentration for this modulatory effect of ITF was 7.6 nM. 4. The EGF-induced increases in SCC were partially inhibited (50%) by piretanide pretreatment, indicating that Cl- secretion is involved. EGF responses either in the presence or absence of ITF were also significantly reduced (84% and 66% respectively) by the cyclo-oxygenase inhibitor, piroxicam, therefore implicating prostaglandins as mediators of EGF-stimulated anion secretion. 5. We conclude that in confluent Col-29 epithelia, basolateral EGF stimulates a predominantly prostaglandin-dependent increase in Cl- secretion that is enhanced by basolateral ITF, and that these two peptides may interact in normal and damaged mucosa to alter the local apical solute and fluid environment. PMID:7647987

  15. Determining an age for the Inararo Tuff eruption of Mt. Pinatubo, based on correlation with a distal ash layer in core MD97-2142, South China Sea

    USGS Publications Warehouse

    Ku, Y.-P.; Chen, C.-H.; Newhall, C.G.; Song, S.-R.; Yang, T.F.; Iizuka, Y.; McGeehin, J.

    2008-01-01

    The largest known eruption of Mt. Pinatubo in the late Quaternary was the Inararo Tuff Formation (ITF) eruption, roughly estimated as five times larger than the 1991 eruption. The precise age of the ITF eruption has been uncertain. Here, a correlative of the ITF eruption, Layer D, is identified in marine sediments, and an age obtained. Tephras were identified in core MD97-2142 of Leg II of the IMAGES III cruise in northern offshore of Palawan, southeastern South China Sea (12??41.33???N, 119??27.90???E). On the basis of the geochemical and isotopic fingerprints, Layer D can be correlated with the ITF eruption of the modern Pinatubo-eruption sequence. By means of the MD97-2142 SPECMAP chronology, Layer D was dated at around 81??2 ka. This estimated age of the ITF eruption and tephra Layer D coincides with an anomalously high SO4-2 spike occurring within the 5 millennia from 79 to 84 ka in the GISP2 ice core record. ?? 2007.

  16. Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut

    PubMed Central

    Rivière, Audrey; Selak, Marija; Lantin, David; Leroy, Frédéric; De Vuyst, Luc

    2016-01-01

    With the increasing amount of evidence linking certain disorders of the human body to a disturbed gut microbiota, there is a growing interest for compounds that positively influence its composition and activity through diet. Besides the consumption of probiotics to stimulate favorable bacterial communities in the human gastrointestinal tract, prebiotics such as inulin-type fructans (ITF) and arabinoxylan-oligosaccharides (AXOS) can be consumed to increase the number of bifidobacteria in the colon. Several functions have been attributed to bifidobacteria, encompassing degradation of non-digestible carbohydrates, protection against pathogens, production of vitamin B, antioxidants, and conjugated linoleic acids, and stimulation of the immune system. During life, the numbers of bifidobacteria decrease from up to 90% of the total colon microbiota in vaginally delivered breast-fed infants to <5% in the colon of adults and they decrease even more in that of elderly as well as in patients with certain disorders such as antibiotic-associated diarrhea, inflammatory bowel disease, irritable bowel syndrome, obesity, allergies, and regressive autism. It has been suggested that the bifidogenic effects of ITF and AXOS are the result of strain-specific yet complementary carbohydrate degradation mechanisms within cooperating bifidobacterial consortia. Except for a bifidogenic effect, ITF and AXOS also have shown to cause a butyrogenic effect in the human colon, i.e., an enhancement of colon butyrate production. Butyrate is an essential metabolite in the human colon, as it is the preferred energy source for the colon epithelial cells, contributes to the maintenance of the gut barrier functions, and has immunomodulatory and anti-inflammatory properties. It has been shown that the butyrogenic effects of ITF and AXOS are the result of cross-feeding interactions between bifidobacteria and butyrate-producing colon bacteria, such as Faecalibacterium prausnitzii (clostridial cluster IV) and Anaerostipes, Eubacterium, and Roseburia species (clostridial cluster XIVa). These kinds of interactions possibly favor the co-existence of bifidobacterial strains with other bifidobacteria and with butyrate-producing colon bacteria in the human colon. PMID:27446020

  17. Middle infratemporal fossa less invasive approach for radical resection of parapharyngeal tumors: surgical microanatomy and clinical application.

    PubMed

    Nonaka, Yoichi; Fukushima, Takanori; Watanabe, Kentaro; Sakai, Jun; Friedman, Allan H; Zomorodi, Ali R

    2016-01-01

    Surgery of the infratemporal fossa (ITF) and parapharyngeal area presents a formidable challenge to the surgeon due to its anatomical complexity and limited access. Conventional surgical approaches to these regions were often too invasive and necessitate sacrifice of normal function and anatomy. To describe a less invasive transcranial extradural approach to ITF parapharyngeal lesions and to determine its advantages, 17 patients with ITF parapharyngeal neoplasms who underwent tumor resection via this approach were enrolled in the study. All lesions located in the ITF precarotid parapharyngeal space were resected through a small operative corridor between the trigeminal nerve third branch (V3) and the temporomandibular joint (TMJ). Surgical outcomes and postoperative complications were evaluated. Pathological diagnosis included schwannoma in eight cases, paraganglioma in two cases, gangliocytoma in two cases, carcinosarcoma in one case, giant cell tumor in one case, pleomorphic adenoma in one case, chondroblastoma in one case, and juvenile angiofibroma in one case. Gross total resection was achieved in 12 cases, near-total and subtotal resection were in 3 and 2 cases, respectively. The most common postoperative complication was dysphagia. Surgical exposure can be customized from minimal (drilling of retrotrigeminal area) to maximal (full skeletonization of V3, removal of all structures lying lateral to the petrous segment of internal carotid artery) according to tumor size and location. Since the space between the V3 and TMJ is the main corridor of this approach, the key maneuver is the anterior translocation of V3 to obtain an acceptable surgical field.

  18. Changes in Indonesian Outflow in relation to East Asian Monsoon and ENSO Activities since the Last Glacial

    NASA Astrophysics Data System (ADS)

    Xu, J.

    2013-12-01

    The Indonesian Throughflow (ITF) links upper ocean waters of the west Pacific and Indian Ocean, modulates heat and fresh water budgets between these oceans and in turn plays an important role in global climate change. It was suggested that East Asian monsoon and El Niño-Southern Oscillation (ENSO) exert a strong influence on flux, water properties and vertical stratification of the modern ITF. Possible link of the ITF to ENSO is also supported by significant linear correlation (R2=0.43) between thermocline temperature (TT) of the ITF outflow and NINO3.4 index over the past 50 years. In this work, seawater temperatures and salinity and vertical thermal structure of the ITF outflow since the last glacial were reconstructed from Core SO18462 that was retrieved from exit of the ITF to the Timor Sea (TS) (Holbourn et al., 2011). The records of Core SO18462 were then compared with records of Core 3cBX that were considered to reveal ENSO-like conditions in the center of the western Pacific warm pool (WPWP) (Sagawa et al., 2012). The results show that surface waters were comparable in the TS and the WPWP prior to ~16ka, and then diverged with much freshening in the TS. On the contrary, thermocline waters were largely diverged, warmer and more saline in the TS than in the WPWP, and then started to converge from ~16ka. Sea surface temperature (SST) remained over 28°C (the temperature defining range of modern WPWP) in both of the regions during 11.5-6ka. SST then slightly decreased below 28°C in the TS when it kept all the way above 28°C in the WPWP towards the late Holocene. In contrast, TT and thermocline depth remained overall unchanged in the WPWP, concurring with decreasing of TT and shoaling of thermocline in the TS during 11.5-6ka. After 6ka, thermocline continued shoaling in the TS, when TT remained decreasing and thermocline salinity approached to be similar in both of the regions. Comparison of TS and WPWP records conspicuously disclose two categories of mechanisms in controlling changes of the ITF outflow after the ITF recovered during ~16-11.5ka. It is speculated that intensified precipitation due to prevailed East Asian summer monsoon and possible ENSO-like cold phase during the early Holocene (11.5-6ka) significantly freshened surface waters over the Indonesian Seas, impeding ITF surface flow and in turn enhanced thermocline flow. Continuous cooling of ITF thermocline waters and shoaling of thermocline depth in the TS after 6ka were partially related to impedance of ITF surface flow, which is however very likely caused by fresh surface water plug driven by winter monsoon, as it operates today (Gordon, 2005). More frequent ENSO-like events during the mid-to-late Holocene may play an additional role, as eastward movement of the warm pool is concomitant with shoaling and cooling of thermocline in the WPWP during modern ENSO events.

  19. Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women.

    PubMed

    Dewulf, Evelyne M; Cani, Patrice D; Claus, Sandrine P; Fuentes, Susana; Puylaert, Philippe G B; Neyrinck, Audrey M; Bindels, Laure B; de Vos, Willem M; Gibson, Glenn R; Thissen, Jean-Paul; Delzenne, Nathalie M

    2013-08-01

    To highlight the contribution of the gut microbiota to the modulation of host metabolism by dietary inulin-type fructans (ITF prebiotics) in obese women. A double blind, placebo controlled, intervention study was performed with 30 obese women treated with ITF prebiotics (inulin/oligofructose 50/50 mix; n=15) or placebo (maltodextrin; n=15) for 3 months (16 g/day). Blood, faeces and urine sampling, oral glucose tolerance test, homeostasis model assessment and impedancemetry were performed before and after treatment. The gut microbial composition in faeces was analysed by phylogenetic microarray and qPCR analysis of 16S rDNA. Plasma and urine metabolic profiles were analysed by 1H-NMR spectroscopy. Treatment with ITF prebiotics, but not the placebo, led to an increase in Bifidobacterium and Faecalibacterium prausnitzii; both bacteria negatively correlated with serum lipopolysaccharide levels. ITF prebiotics also decreased Bacteroides intestinalis, Bacteroides vulgatus and Propionibacterium, an effect associated with a slight decrease in fat mass and with plasma lactate and phosphatidylcholine levels. No clear treatment clustering could be detected for gut microbial analysis or plasma and urine metabolomic profile analyses. However, ITF prebiotics led to subtle changes in the gut microbiota that may importantly impact on several key metabolites implicated in obesity and/or diabetes. ITF prebiotics selectively changed the gut microbiota composition in obese women, leading to modest changes in host metabolism, as suggested by the correlation between some bacterial species and metabolic endotoxaemia or metabolomic signatures.

  20. [The regulation of FSH release by the testis. Studies on inhibin].

    PubMed

    Krause, W

    1977-05-12

    The FSH release from the hypophysis is suggested to be particularly regulated by a testicular hormone called inhibin. Origin, structure and target organs of inhibin are unknown. Experiments to test some hypotheses in this field are described. Adult male rats, prenatally treated with busulfan, show only Sertoli cells in the semiferous tubules. Experimental cryptorchidism and orchidectomy, however, leads to an increase in FSH levels as observed in normal animals. This indicates the role of Sertoli cells in FSH regulation. Ligation of efferent ducts of testes leads to an increase of FSH levels, too, indicating that an FSH-inhibiting principle cannot be absorbed. Interstitial testis fluid (ITF) of normal rats was applicated to immature female rats. Their FSH release is inhibited, visible in the lower ovarian weight gain following additional hCG-administration. Orchidectomized animals react with a decrease of FSH levels to the application of ITF. Therefore ITF seems to contain a FSH-inhibiting factor. Androgen binding protein-content of epididymes, however, is increased after repeated injections of ITF. It is concluded that testis (probably the Sertoli cells) produces a FSH-inhibiting factor, but ITF contains only small amounts of inhibin.

  1. Leishmaniasis sand fly vector density reduction is less marked in destitute housing after insecticide thermal fogging.

    PubMed

    Chaves, Luis Fernando; Calzada, Jose E; Rigg, Chystrie; Valderrama, Anayansi; Gottdenker, Nicole L; Saldaña, Azael

    2013-06-06

    Insecticide thermal fogging (ITF) is a tool to control vector borne diseases. Insecticide application success for vector control has been associated with housing materials and architecture. Vector abundance is correlated with weather changes. Nevertheless, housing quality and weather impacts on vector abundance have been unaccounted for in most New World insecticide control trials for leishmaniasis vectors. We conducted a 15 month insecticide control trial that included two deltamethrin [6 mg a.i.m-2] based ITF interventions in 12 of 24 monitored houses at Trinidad de Las Minas, a hyperendemic cutaneous leishmaniasis transmission village in western Panamá. During the study we followed sand fly (SF) abundance, keeping track of rainfall and quantified housing quality using an index based on architecture and construction materials. We found a 50 to 80% reduction in SF density in the fogged houses when compared with control houses, while controlling for seasonal changes in SF abundance associated with rainfall. We found heterogeneities in the reductions, as abundance changed according to SF species: Lutzomyia gomezi, Lu. panamensis, Lu. dysponeta and Lu. triramula reduced in density between 40% and 90% after ITF. In contrast, Lu. trapidoi density increased 5% after ITF. Differences in the impact of ITF were associated with housing quality, the most destitute houses, i.e., those with features that ease insect entrance, had a disproportionally larger SF abundance, in some cases with increased domiciliary SF density following the ITF. Our results suggest the potential of insecticide application to control SF density and leishmaniasis transmission could depend on housing quality beyond insecticide efficiency.

  2. The cause of outliers in electromagnetic pulse (EMP) locations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fenimore, Edward E.

    2014-10-02

    We present methods to calculate the location of EMP pulses when observed by 5 or more satellites. Simulations show that, even with a good initial guess and fitting a location to all of the data, there are sometime outlier results whose locations are much worse than most cases. By comparing simulations using different ionospheric transfer functions (ITFs), it appears that the outliers are caused by not including the additional path length due to refraction rather than being caused by not including higher order terms in the Appleton-Hartree equation. We suggest ways that the outliers can be corrected. These correction methodsmore » require one to use an electron density profile along the line of sight from the event to the satellite rather than using the total electron content (TEC) to characterize the ionosphere.« less

  3. Positive interaction between prebiotics and thiazolidinedione treatment on adiposity in diet-induced obese mice.

    PubMed

    Alligier, Maud; Dewulf, Evelyne M; Salazar, Nuria; Mairal, Aline; Neyrinck, Audrey M; Cani, Patrice D; Langin, Dominique; Delzenne, Nathalie M

    2014-07-01

    To investigate whether inulin-type fructan (ITF) prebiotics could counteract the thiazolidinedione (TZD, PPARγ activator) induced-fat mass gain, without affecting its beneficial effect on glucose homeostasis, in high-fat (HF) diet fed mice. Male C57bl6/J mice were fed a HF diet alone or supplemented with ITF prebiotics (0.2 g/day × mouse) or TZD (30 mg pioglitazone (PIO)/kg body weight × day) or both during 4 weeks. An insulin tolerance test was performed after 3 weeks of treatment. As expected, PIO improved glucose homeostasis and increased adiponectinaemia. Furthermore, it induced an over-expression of several PPARγ target genes in white adipose tissues. ITF prebiotics modulated the PIO-induced PPARγ activation in a tissue-dependent manner. The co-treatment with ITF prebiotics and PIO maintained the beneficial impact of TZD on glucose homeostasis and adiponectinaemia. Moreover, the combination of both treatments reduced fat mass accumulation, circulating lipids and hepatic triglyceride content, suggesting an overall improvement of metabolism. Finally, the co-treatment favored induction of white-to-brown fat conversion in subcutaneous adipose tissue, thereby leading to the development of brite adipocytes that could increase the oxidative capacity of the tissue. ITF prebiotics decrease adiposity and improve the metabolic response in HF fed mice treated with TZD. © 2014 The Obesity Society.

  4. Leishmaniasis sand fly vector density reduction is less marked in destitute housing after insecticide thermal fogging

    PubMed Central

    2013-01-01

    Background Insecticide thermal fogging (ITF) is a tool to control vector borne diseases. Insecticide application success for vector control has been associated with housing materials and architecture. Vector abundance is correlated with weather changes. Nevertheless, housing quality and weather impacts on vector abundance have been unaccounted for in most New World insecticide control trials for leishmaniasis vectors. Methods We conducted a 15 month insecticide control trial that included two deltamethrin [6 mg a.i.m-2] based ITF interventions in 12 of 24 monitored houses at Trinidad de Las Minas, a hyperendemic cutaneous leishmaniasis transmission village in western Panamá. During the study we followed sand fly (SF) abundance, keeping track of rainfall and quantified housing quality using an index based on architecture and construction materials. Results We found a 50 to 80% reduction in SF density in the fogged houses when compared with control houses, while controlling for seasonal changes in SF abundance associated with rainfall. We found heterogeneities in the reductions, as abundance changed according to SF species: Lutzomyia gomezi, Lu. panamensis, Lu. dysponeta and Lu. triramula reduced in density between 40% and 90% after ITF. In contrast, Lu. trapidoi density increased 5% after ITF. Differences in the impact of ITF were associated with housing quality, the most destitute houses, i.e., those with features that ease insect entrance, had a disproportionally larger SF abundance, in some cases with increased domiciliary SF density following the ITF. Conclusion Our results suggest the potential of insecticide application to control SF density and leishmaniasis transmission could depend on housing quality beyond insecticide efficiency. PMID:23742709

  5. Estimated Probability of a Cervical Spine Injury During an ISS Mission

    NASA Technical Reports Server (NTRS)

    Brooker, John E.; Weaver, Aaron S.; Myers, Jerry G.

    2013-01-01

    Introduction: The Integrated Medical Model (IMM) utilizes historical data, cohort data, and external simulations as input factors to provide estimates of crew health, resource utilization and mission outcomes. The Cervical Spine Injury Module (CSIM) is an external simulation designed to provide the IMM with parameter estimates for 1) a probability distribution function (PDF) of the incidence rate, 2) the mean incidence rate, and 3) the standard deviation associated with the mean resulting from injury/trauma of the neck. Methods: An injury mechanism based on an idealized low-velocity blunt impact to the superior posterior thorax of an ISS crewmember was used as the simulated mission environment. As a result of this impact, the cervical spine is inertially loaded from the mass of the head producing an extension-flexion motion deforming the soft tissues of the neck. A multibody biomechanical model was developed to estimate the kinematic and dynamic response of the head-neck system from a prescribed acceleration profile. Logistic regression was performed on a dataset containing AIS1 soft tissue neck injuries from rear-end automobile collisions with published Neck Injury Criterion values producing an injury transfer function (ITF). An injury event scenario (IES) was constructed such that crew 1 is moving through a primary or standard translation path transferring large volume equipment impacting stationary crew 2. The incidence rate for this IES was estimated from in-flight data and used to calculate the probability of occurrence. The uncertainty in the model input factors were estimated from representative datasets and expressed in terms of probability distributions. A Monte Carlo Method utilizing simple random sampling was employed to propagate both aleatory and epistemic uncertain factors. Scatterplots and partial correlation coefficients (PCC) were generated to determine input factor sensitivity. CSIM was developed in the SimMechanics/Simulink environment with a Monte Carlo wrapper (MATLAB) used to integrate the components of the module. Results: The probability of generating an AIS1 soft tissue neck injury from the extension/flexion motion induced by a low-velocity blunt impact to the superior posterior thorax was fitted with a lognormal PDF with mean 0.26409, standard deviation 0.11353, standard error of mean 0.00114, and 95% confidence interval [0.26186, 0.26631]. Combining the probability of an AIS1 injury with the probability of IES occurrence was fitted with a Johnson SI PDF with mean 0.02772, standard deviation 0.02012, standard error of mean 0.00020, and 95% confidence interval [0.02733, 0.02812]. The input factor sensitivity analysis in descending order was IES incidence rate, ITF regression coefficient 1, impactor initial velocity, ITF regression coefficient 2, and all others (equipment mass, crew 1 body mass, crew 2 body mass) insignificant. Verification and Validation (V&V): The IMM V&V, based upon NASA STD 7009, was implemented which included an assessment of the data sets used to build CSIM. The documentation maintained includes source code comments and a technical report. The software code and documentation is under Subversion configuration management. Kinematic validation was performed by comparing the biomechanical model output to established corridors.

  6. Effect of inulin-type fructans on blood lipid profile and glucose level: a systematic review and meta-analysis of randomized controlled trials.

    PubMed

    Liu, F; Prabhakar, M; Ju, J; Long, H; Zhou, H-W

    2017-01-01

    This systematic review and meta-analysis was performed to assess the effects of inulin-type fructans (ITF) on human blood lipids and glucose homeostasis associated with metabolic abnormalities, including dyslipidemia, overweight or obesity, and type-2 diabetes mellitus (T2DM). The MEDLINE, EMBASE and Cochrane Library databases were systematically searched for randomized controlled trials (RCTs) before January 2016. Human trials that investigated the effects of ITF supplementation on the lipid profile, fasting glucose and insulin were included using Review Manager 5.3. Twenty RCTs with 607 adult participants were included in this systematic review and meta-analysis. In the overall analysis, the supplementation of ITF reduced only the low density lipoprotein-cholesterol (LDL-c) (mean difference (MD): -0.15; 95% confidence interval (CI): -0.29, -0.02; P=0.03) without affecting the other endpoints. Within the T2DM subgroup analysis, ITF supplementation was positively associated with a decreased fasting insulin concentration (MD: -4.01; 95% CI: -5.92, -2.09; P<0.0001) and increased high density lipoprotein-cholesterol (HDL-c) (MD: 0.07; 95% CI: 0, 0.14; P=0.05). Moreover, a reduced fasting glucose tendency was identified only in the T2DM subgroup (MD: -0.42; 95% CI: -0.90, 0.06; P=0.09). There was a potential publication bias, and few trials were available for the T2DM subgroup analysis. In summary, the use of ITF may have benefits for LDL-c reduction across all study populations, whereas HDL-c improvement and glucose control were demonstrated only in the T2DM subgroup. Thus, additional, well-powered, long-term, randomized clinical trials are required for a definitive conclusion. Overall, ITF supplementation may provide a novel direction for improving the lipid profile and glucose metabolism.

  7. Video in Distance Education: ITFS vs. Web-Streaming--Evaluation of Student Attitudes

    ERIC Educational Resources Information Center

    Reisslein, Jana; Seeling, Patrick; Reisslein, Martin

    2005-01-01

    The use of video in distance education courses has a long tradition, with many colleges and universities having been delivering distance education courses with video since the 80's using the Instructional Television Fixed Service (ITFS) and cable television. With the emergence of the Internet and the increased access bandwidths from private homes…

  8. Designing and Evaluating Tutoring Feedback Strategies for Digital Learning Environments on the Basis of the Interactive Tutoring Feedback Model

    ERIC Educational Resources Information Center

    Narciss, Susanne

    2013-01-01

    This paper describes the interactive tutoring feedback model (ITF-model; Narciss, 2006; 2008), and how it can be applied to the design and evaluation of feedback strategies for digital learning environments. The ITF-model conceptualizes formative tutoring feedback as a multidimensional instructional activity that aims at contributing to the…

  9. Estimation of muscle torque in various combat sports.

    PubMed

    Pędzich, Wioletta; Mastalerz, Andrzej; Sadowski, Jerzy

    2012-01-01

    The purpose of the research was to compare muscle torque of elite combat groups. Twelve taekwondo WTF athletes, twelve taekwondo ITF athletes and nine boxers participated in the study. Measurements of muscle torques were done under static conditions on a special stand which belonged to the Department of Biomechanics. The sum of muscle torque of lower right and left extremities of relative values was significantly higher for taekwondo WTF athletes than for boxers (16%, p < 0.001 for right and 10%, p < 0.05 for left extremities) and taekwondo ITF (10%, p < 0.05 for right and 8% for left extremities). Taekwondo ITF athletes attained significantly higher absolute muscle torque values than boxers for elbow flexors (20%, p < 0.05 for right and 11% for left extremities) and extensors (14% for right and 18%, p < 0.05 for left extremities) and shoulder flexors (10% for right and 12%, p < 0.05 for left extremities) and extensors (11% for right and 1% for left extremities). Taekwondo WTF and taekwondo ITF athletes obtained significantly different relative values of muscle torque of the hip flexors (16%, p < 0.05) and extensors (11%, p < 0.05) of the right extremities.

  10. HIV/AIDS, health and wellbeing study among International Transport Workers' Federation (ITF) seafarer affiliates.

    PubMed

    Altaf Chowdhury, Syed Asif; Smith, Jacqueline; Trowsdale, Steve; Leather, Susan

    2016-01-01

    Transport workers generally face a higher-than-average risk of HIV as well as other health challenges. In order to improve understanding of health issues in the maritime sector, including but not limited to HIV/AIDS, and to prepare appropriate responses the International Transport Workers' Federation (ITF) conducted a study of the views and needs of those affiliates. The ITF carried out two surveys. The first consisted of a questionnaire sent to all ITF seafarer affiliates to establish their concerns about health issues, including the impact of HIV/AIDS, and to assess the extent and nature of existing trade union programmes. The second consisted of a knowledge, attitude and behaviour survey on health, wellbeing and AIDS among a cross-section of individual members administered through anonymous and confidential questionnaires by maritime affiliates in four countries in different regions and an identical online questionnaire through Survey Monkey. For the first survey, replies were received from 35 unions in 30 countries, including major seafarer supplying countries - India, Indonesia, Myanmar, Philippines, Turkey, Ukraine - and major beneficial ownership countries such as Germany, Italy, Norway, and South Korea. Health issues of concern included HIV and other sexually transmitted infections for over three-quarters of them, and then alcohol use, weight control, and mental health. All said they would welcome ITF support in starting or strengthening a programme on general health and/or HIV. Replies were received to the second survey from 615 individual seafarers. Half to three-quarters said they worried about their weight, lack of exercise and drinking; over half felt depressed sometimes or often. There were serious knowledge gaps in a number of areas, especially HIV transmission and prevention, as well as high levels of stigma towards workmates with HIV. A number of health issues and information gaps remain unaddressed on board and pre-departure. Mental health is especially neglected but the needs emerge clearly. Seafarers believe that companies should provide programmes but also look to their unions for health information and services. The ITF has an important role to play in supporting affiliated unions in developing activities and in providing technical and strategic guidance.

  11. Marshall Space Flight Center's Impact Testing Facility Capabilities

    NASA Technical Reports Server (NTRS)

    Evans, Steve; Finchum, Andy; Hubbs, Whitney; Gray, Perry

    2008-01-01

    Marshall Space Flight Center's (MSFC) Impact Testing Facility (ITF) serves as an important installation for space and missile related materials science research. The ITF was established and began its research in spacecraft debris shielding in the early 1960s, then played a major role in the International Space Station debris shield development. As NASA became more interested in launch debris and in-flight impact concerns, the ITF grew to include research in a variety of impact genres. Collaborative partnerships with the DoD led to a wider range of impact capabilities being relocated to MSFC as a result of the closure of Particle Impact Facilities in Santa Barbara, California, The Particle Impact Facility had a 30 year history in providing evaluations of aerospace materials and components during flights through rain, ice, and solid particle environments at subsonic through hypersonic velocities. The facility's unique capabilities were deemed a 'National Asset' by the DoD, The ITF now has capabilities including environmental, ballistic, and hypervelocity impact testing utilizing an array of air, powder, and two-stage light gas guns to accommodate a variety of projectile and target types and sizes. Relocated test equipment was dated and in need of upgrade. Numerous upgrades including new instrumentation, triggering circuitry, high speed photography, and optimized sabot designs have been implemented. Other recent research has included rain drop demise characterization tests to obtain data for inclusion in on-going model development. Future ITF improvements will be focused on continued instrumentation and performance enhancements. These enhancements will allow further, more in-depth, characterization of rain drop demise characterization and evaluation of ice crystal impact. Performance enhancements also include increasing the upper velocity limit of the current environmental guns to allow direct environmental simulation for missile components. The current and proposed ITF capabilities range from rain to micrometeoroids allowing the widest test parameter range possible for materials investigations in support of space, atmospheric, and ground environments. These test capabilities including hydrometeor, single/multi-particle, ballistic gas guns, exploding wire gun, and light gas guns combined with Smooth Particle Hydrodynamics Code (SPHC) simulations represent the widest range of impact test capabilities in the country.

  12. Marshall Space Flight Center's Impact Testing Facility Capabilities

    NASA Technical Reports Server (NTRS)

    Evans, Steve; Finchum, Andy; Hubbs, Whitney

    2008-01-01

    Marshall Space Flight Center's (MSFC) Impact Testing Facility (ITF) serves as an important installation for space and missile related materials science research. The ITF was established and began its research in spacecraft debris shielding in the early 1960% then played a major role in the International Space Station debris shield development. As NASA became more interested in launch debris and in-flight impact concerns, the ITF grew to include research in a variety of impact genres. Collaborative partnerships with the DoD led to a wider range of impact capabilities being relocated to MSFC as a result of the closure of Particle Impact Facilities in Santa Barbara, California. The Particle Impact Facility had a 30 year history in providing evaluations of aerospace materials and components during flights through rain, ice, and solid particle environments at subsonic through hypersonic velocities. The facility's unique capabilities were deemed a "National Asset" by the DoD. The ITF now has capabilities including environmental, ballistic, and hypervelocity impact testing utilizing an array of air, powder, and two-stage light gas guns to accommodate a variety of projectile and target types and sizes. Relocated test equipment was dated and in need of upgrade. Numerous upgrades including new instrumentation, triggering circuitry, high speed photography, and optimized sabot designs have been implemented. Other recent research has included rain drop demise characterization tests to obtain data for inclusion in on-going model development. Future ITF improvements will be focused on continued instrumentation and performance enhancements. These enhancements will allow further, more in-depth, characterization of rain drop demise characterization and evaluation of ice crystal impact. Performance enhancements also include increasing the upper velocity limit of the current environmental guns to allow direct environmental simulation for missile components. The current and proposed ITF capabilities range from rain to micrometeoroids allowing the widest test parameter range possible for materials investigations in support of space, atmospheric, and ground environments. These test capabilities including hydrometeor, single/multi-particle, ballistic gas grins, exploding wire gun, and light gas guns combined with Smooth Particle Hydrodynamics Code (SPHC) simulations represent the widest range of impact test capabilities in the country.

  13. Marshall Space Flight Center's Impact Testing Facility Capabilities

    NASA Technical Reports Server (NTRS)

    Finchum, Andy; Hubbs, Whitney; Evans, Steve

    2008-01-01

    Marshall Space Flight Center s (MSFC) Impact Testing Facility (ITF) serves as an important installation for space and missile related materials science research. The ITF was established and began its research in spacecraft debris shielding in the early 1960s, then played a major role in the International Space Station debris shield development. As NASA became more interested in launch debris and in-flight impact concerns, the ITF grew to include research in a variety of impact genres. Collaborative partnerships with the DoD led to a wider range of impact capabilities being relocated to MSFC as a result of the closure of Particle Impact Facilities in Santa Barbara, California. The Particle Impact Facility had a 30 year history in providing evaluations of aerospace materials and components during flights through rain, ice, and solid particle environments at subsonic through hypersonic velocities. The facility s unique capabilities were deemed a "National Asset" by the DoD. The ITF now has capabilities including environmental, ballistic, and hypervelocity impact testing utilizing an array of air, powder, and two-stage light gas guns to accommodate a variety of projectile and target types and sizes. Numerous upgrades including new instrumentation, triggering circuitry, high speed photography, and optimized sabot designs have been implemented. Other recent research has included rain drop demise characterization tests to obtain data for inclusion in on-going model development. The current and proposed ITF capabilities range from rain to micrometeoroids allowing the widest test parameter range possible for materials investigations in support of space, atmospheric, and ground environments. These test capabilities including hydrometeor, single/multi-particle, ballistic gas guns, exploding wire gun, and light gas guns combined with Smooth Particle Hydrodynamics Code (SPHC) simulations represent the widest range of impact test capabilities in the country.

  14. Interferometric temporal focusing microscopy using three-photon excitation fluorescence.

    PubMed

    Toda, Keisuke; Isobe, Keisuke; Namiki, Kana; Kawano, Hiroyuki; Miyawaki, Atsushi; Midorikawa, Katsumi

    2018-04-01

    Super-resolution microscopy has become a powerful tool for biological research. However, its spatial resolution and imaging depth are limited, largely due to background light. Interferometric temporal focusing (ITF) microscopy, which combines structured illumination microscopy and three-photon excitation fluorescence microscopy, can overcome these limitations. Here, we demonstrate ITF microscopy using three-photon excitation fluorescence, which has a spatial resolution of 106 nm at an imaging depth of 100 µm with an excitation wavelength of 1060 nm.

  15. Shock ignition targets: gain and robustness vs ignition threshold factor

    NASA Astrophysics Data System (ADS)

    Atzeni, Stefano; Antonelli, Luca; Schiavi, Angelo; Picone, Silvia; Volponi, Gian Marco; Marocchino, Alberto

    2017-10-01

    Shock ignition is a laser direct-drive inertial confinement fusion scheme, in which the stages of compression and hot spot formation are partly separated. The hot spot is created at the end of the implosion by a converging shock driven by a final ``spike'' of the laser pulse. Several shock-ignition target concepts have been proposed and relevant gain curves computed (see, e.g.). Here, we consider both pure-DT targets and more facility-relevant targets with plastic ablator. The investigation is conducted with 1D and 2D hydrodynamic simulations. We determine ignition threshold factors ITF's (and their dependence on laser pulse parameters) by means of 1D simulations. 2D simulations indicate that robustness to long-scale perturbations increases with ITF. Gain curves (gain vs laser energy), for different ITF's, are generated using 1D simulations. Work partially supported by Sapienza Project C26A15YTMA, Sapienza 2016 (n. 257584), Eurofusion Project AWP17-ENR-IFE-CEA-01.

  16. Climatic Influences on Southern Makassar Strait Salinity Over the Past Century

    NASA Astrophysics Data System (ADS)

    Murty, S. A.; Goodkin, N. F.; Halide, H.; Natawidjaja, D.; Suwargadi, B.; Suprihanto, I.; Prayudi, D.; Switzer, A. D.; Gordon, A. L.

    2017-12-01

    The Indonesian Throughflow (ITF) is a globally important ocean current that fuels heat and buoyancy fluxes throughout the Indo-Pacific and is known to covary in strength with the El Niño Southern Oscillation at interannual time scales. A climate system with a less well-quantified impact on the ITF is the East Asian Winter Monsoon (EAWM), which drives less saline surface waters from the South China Sea (SCS) into the Makassar Strait, obstructing surface ITF flow. We present a subannually resolved record of sea surface salinity (SSS) from 1927 to 2011 based on coral δ18O from the Makassar Strait that reveals variability in the relative contributions of different source waters to the surface waters of the Makassar Strait during the boreal winter monsoon. We find that the EAWM (January-March) strongly influences interannual SSS variability during boreal winter over the twentieth century (r = 0.54, p << 0.0001), impacting surface water circulation in the SCS and Indonesian Seas.

  17. Multi-decadal timeseries of the Indonesian throughflow

    NASA Astrophysics Data System (ADS)

    Li, Mingting; Gordon, Arnold L.; Wei, Jun; Gruenburg, Laura K.; Jiang, Guoqing

    2018-03-01

    NCEP reanalysis wind data from 1948 to 2016 and Makassar Strait transport from 2004 to 2011 are used to construct a multi-decadal timeseries of 0-300 m Makassar Throughflow using a back-propagation (BP) neural network. Based on the 2004-2015 Makassar timeseries, 0-300 m transport accounts for 75% (±8%) of the total Makassar throughflow. Results from the INSTANT program 2004-2006 indicate that the Makassar throughflow provides 78% of the Indonesian Throughflow (ITF) within the upper 1000 m (77% of the full depth ITF). As the ITF is driven largely by North Pacific winds, we use the North Pacific zonal wind to construct a 68-year timeseries of 0-300 m Makassar Throughflow to trace interannual to decadal variability. The constructed timeseries has a mean transport of 9.2 ± 1 Sv within the 0-300 m layer. Using the 2004-2015 statistics this converts to a total Makassar Strait throughflow of 12.2 Sv and using the 2004-2006 INSTANT data, to a total ITF within the upper kilometer of 14.7 Sv. The Makassar throughflow decreases from 1948 to 1995, increases after 1995, then rapidly decreases after 2013, which agrees with the Pacific to Indian inter-ocean pressure difference across the Indonesian seas based on SODA reanalysis with a correlation coefficients of 0.6. The Pacific Decadal Oscillation (PDO) and El Nino-Southern Oscillation (ENSO), have correlation coefficients with the constructed Makassar throughflow of -0.6 and -0.4 respectively.

  18. Indian Ocean circulation changes over the Middle Pleistocene Transition.

    NASA Astrophysics Data System (ADS)

    Petrick, B.; Auer, G.; De Vleeschouwer, D.; Christensen, B. A.; Stolfi, C.; Reuning, L.; Martinez-Garcia, A.; Haug, G. H.; Bogus, K.

    2017-12-01

    The Mid-Pleistocene Transition (MPT; 1.4 - 0.4 Ma) represents a climatic shift towards climate cycles at a quasi-100-kyr frequency. Although, several high-resolution records covering the MPT from globally distributed archives exist, there is only sparse evidence on changes in heat exchange between the Pacific and Indian Oceans, which represents a crucial part of the global thermohaline circulation (THC). Deciphering the influence of this heat exchange via the Indonesian Throughflow (ITF) is an important step in understanding the causes of the MPT. The Leeuwin Current off Western Australia is directly influenced by the ITF and can therefore be used to reconstruct ITF variability during the MPT. Today, the Leeuwin Current is the only southward flowing eastern boundary current in the southern hemisphere. The onset of the current is unknown but is proposed to have occurred 1 Ma and was likely related to significant changes in ITF dynamics during the MPT We present the first continuous reconstruction of changes in the Leeuwin Current during the MPT using data from IODP Expedition 356 Site U1460. The site is located at 29°S in the path of the current. High sedimentation rates ( 30 cm/ka) at Site U1460 provide the opportunity for high-resolution reconstruction of the MPT. We reconstruct paleoenvironmental variability by combining XRF, organic geochemistry, ICP-MS and XRD data with shipboard data, to reconstruct Leeuwin Current and ITF variability. Initial analyses show clear indications that upwelling off Western Australia intensified during the MPT, indicated by increased primary productivity related to increased nutrient levels, from 900-600 ka. Our results also suggest that the west Australian current (WAC) strengthened during this time supplying cool eutrophic waters from the high southern latitutes to the site. This intensification of the WAC may have had major implications for the Indian Ocean current system, but also the THC at large. This seems to be coupled with increased rainfall to western Australia after 600 ka. The data suggests a major reording of local currents during the MPT.

  19. The bomb 14C transient in the Pacific Ocean

    NASA Astrophysics Data System (ADS)

    Rodgers, Keith B.; Schrag, Daniel P.; Cane, Mark A.; Naik, Naomi H.

    2000-04-01

    A modeling study of the bomb 14C transient is presented for the Pacific Ocean. A primitive equation ocean circulation model has been configured for a high-resolution domain that accounts for the Indonesian Throughflow (ITF). Four separate runs were performed: (1) seasonal forcing with 20 Sv of ITF transport, (2) seasonal forcing with 10 Sv of ITF transport, (3) seasonal forcing with no ITF transport, and (4) interannual forcing with 15 Sv of ITF transport. This study has two main objectives. First, it is intended to describe the time evolution of the bomb 14C transient. This serves as a tool with which one can identify the physical processes controlling the evolving bomb 14C distribution in the Pacific thermocline and thus provides an interpretive framework for the database of Δ14C measurements in the Pacific. Second, transient tracers are applied to the physical oceanographic problem of intergyre exchange. This is of importance in furthering our understanding of the potential role of the upper Pacific Ocean in climate variability. We use bomb 14C as a dye tracer of intergyre exchange between the subtropical gyres and the equatorial upwelling regions of the equatorial Pacific. Observations show that while the atmospheric Δ14C signal peaked in the early to mid-1960s, the Δ14C levels in the surface water waters of the subtropical gyres peaked near 1970, and the Δ14C of surface waters in the equatorial Pacific continued to rise through the 1980s. It is shown that the model exhibits skill in representing the large-scale observed features observed for the bomb 14C transient in the Pacific Ocean. The model successfully captures the basin-scale inventories of bomb 14C in the tropics as well as in the extratropics of the North Pacific. For the equatorial Pacific this is attributed to the model's high meridional resolution. The discrepancies in the three-dimensional distribution of bomb 14C between the model and data are discussed within the context of the dynamical controls on the Δ14C distribution of bomb 14C in the Pacific.

  20. SPCZ Zonal Events and Downstream Influence on Surface Ocean Conditions in the Indonesian Throughflow Region: Implications for SPCZ Mean Position Effects on the ITF

    NASA Astrophysics Data System (ADS)

    Linsley, B. K.; Wu, H. C.; Rixen, T.; Charles, C. D.; Gordon, A. L.; Moore, M.

    2017-12-01

    Seasonal surface freshening of the Makassar Strait, the main conduit of the Indonesian Throughflow (ITF), is a key factor controlling the temperature and salinity characteristics of ITF transport to the Indian Ocean. Here we present a 262-year reconstruction of seasonal sea-surface-salinity (SSS) variability from 1742-2004 C.E. using coral oxygen isotope (δ18O) records from the central Makassar Strait. Our record reveals persistent seasonal freshening and also years with significant truncations of seasonal freshening that correlate exactly with South Pacific Convergence Zone (SPCZ) zonal events >4,000 km to the east. During these newly identified events, the SPCZ dramatically rotates 15° north to near the equator and stronger westward flowing South Pacific boundary currents transport salty water north across the equator and force higher salinity water through the Makassar Strait in February-May halting the normal seasonal freshening in the strait. By these teleconnections, our Makassar coral δ18O series provides the first record of the recurrence interval of these zonal SPCZ events and demonstrates that they have occurred on a semi-regular basis since the mid-1700s. The deeper time implications of these results suggest that long-term changes in the position of the SPCZ and ITCZ in the central equatorial Pacific would affect Pacific western boundary currents and the transport of South Pacific water north across the equator and into the ITF. Preliminary results and plans underway to evaluate this hypothesis over the last 2.5 Ma will also be presented.

  1. Water mass characteristic in the outflow region of the Indonesian throughflow during and post 2016 negative Indian ocean dipole event

    NASA Astrophysics Data System (ADS)

    Bayhaqi, A.; Iskandar, I.; Surinati, D.; Budiman, A. S.; Wardhana, A. K.; Dirhamsyah; Yuan, D.; Lestari, D. O.

    2018-05-01

    Strong El Niño and positive Indian Ocean Dipole (pIOD) events in 2015/2016 followed by relatively strong negative Indian Ocean Dipole (nIOD) and weak La Niña in 2016 events have affected hydrography conditions in the Indonesian Throughflow (ITF) region. Two research cruises were conducted using RV Baruna Jaya VIII in August and November 2016. These cruises aim to evaluate possible impact of those two climate mode events on the water mass characteristic in the outflow region of the ITF. Hydrographic data from those two cruises were combined with the sea surface temperature (SST) from the Advanced Very High Resolution Radiometer (AVHRR) and surface wind data from the European Centre for Medium-Range Weather Forecasts (ECMWF). The results showed that in the 2016 anomaly year, the cooler sea surface temperature was observed during the negative IOD (nIOD) event while the warmer temperature was found in the post of nIOD event. The observed water mass characteristics in the outflow region of the ITF revealed that the upper layer was dominated by the Indian Ocean water mass, while the Pacific Ocean water mass was observed in the deeper layer. The observed current data across the Sumba Strait showed that the South Java Coastal Current (SJCC) was observed in the upper layer, propagating eastward toward the Savu Sea. A few days later, the observed currents in the upper layer of the Ombai Strait revealed the ITF flow towards the Indian Ocean. Meanwhile, the lower layer showed an eastward flow towards the Ombai Strait.

  2. Twentieth century sea surface temperature and salinity variations at Timor inferred from paired coral δ18O and Sr/Ca measurements

    NASA Astrophysics Data System (ADS)

    Cahyarini, Sri Yudawati; Pfeiffer, Miriam; Nurhati, Intan Suci; Aldrian, Edvin; Dullo, Wolf-Christian; Hetzinger, Steffen

    2014-07-01

    The Indonesian Throughflow (ITF), which represents the global ocean circulation connecting the Pacific Warm Pool to the Indian Ocean, strongly influences the Indo-Pacific climate. ITF monitoring since the late 1990s using mooring buoys have provided insights on seasonal and interannual time scales. However, the absence of longer records limits our perspective on its evolution over the past century. Here, we present sea surface temperature (SST) and salinity (SSS) proxy records from Timor Island located at the ITF exit passage via paired coral δ18O and Sr/Ca measurements spanning the period 1914-2004. These high-resolution proxy based climate data of the last century highlights improvements and cautions when interpreting paleoclimate records of the Indonesian region. If the seasonality of SST and SSS is not perfectly in phase, the application of coral Sr/Ca thermometry improves SST reconstructions compared to estimates based on coral δ18O only. Our records also underline the importance of ocean advection besides rainfall on local SSS in the region. Although the El Niño/Southern Oscillation (ENSO) causes larger anomalies relative to the Indian Ocean Dipole (IOD), Timor coral-based SST and SSS records robustly correlate with IOD on interannual time scales, whereas ENSO only modifies Timor SST. Similarly, Timor SST and SSS are strongly linked to Indian Ocean decadal-scale variations that appear to lead Timor oceanographic conditions by about 1.6-2 years. Our study sheds new light on the complex signatures of Indo-Pacific climate modes on SST and SSS dynamics of the ITF. This article was corrected on 8 AUG 2014. See the end of the full text for details.

  3. Capabilities of NASA/Marshall Space Flight Center's Impact Testing Facility

    NASA Technical Reports Server (NTRS)

    Hovater, Mary; Hubbs, Whitney; Finchum, Andy; Evans, Steve; Nehls, Mary

    2006-01-01

    The Impact Testing Facility (ITF) serves as an important installation for materials science at Marshall Space Flight Center (MSFC). With an array of air, powder, and two-stage light gas guns, a variety of projectile and target types and sizes can be accommodated. The ITF allows for simulation of impactors from rain to micrometeoroids and orbital debris on materials being investigated for space, atmospheric, and ground use. Expendable, relatively simple launch assemblies are used to obtain well-documented results for impact conditions comparable to those from ballistic and rocket sled ranges at considerably lower cost. In addition, for applications requiring study of impacts at speeds in excess of those attainable by gun launches, hydrocode simulations, validated by test data, can be used to extend the velocity range. In addition to serving various NASA directorates, the ITF has performed testing on behalf of the European and Russian space agencies, as well as the Department of Defense, and academic institutions. The m s contributions not only enable safer space flight for NASA s astronauts, but can help design materials and structures to protect soldiers and civilians on Earth, through advances in body armor, aircraft survivability, and a variety of other applications.

  4. Application of 3D printing rapid prototyping-assisted percutaneous fixation in the treatment of intertrochanteric fracture.

    PubMed

    Zheng, Sheng-Nai; Yao, Qing-Qiang; Mao, Feng-Yong; Zheng, Peng-Fei; Tian, Shu-Chang; Li, Jia-Yi; Yu, Yi-Fan; Liu, Shuai; Zhou, Jin; Hu, Jun; Xu, Yan; Tang, Kai; Lou, Yue; Wang, Li-Ming

    2017-10-01

    The aim of the present study was to investigate the application of 3D printing (3DP) rapid prototyping (RP) technique-assisted percutaneous fixation in the treatment of femoral intertrochanteric fracture (ITF) using proximal femoral nail anti-rotation (PFNA). A total of 39 patients with unstable ITF were included in the current study. Patients were divided into two groups: 19 patients were examined using computed tomography scanning and underwent PFNA with SDP-RP whereas the other 20 patients underwent conventional PFNA treatment. Anatomical data were converted from the Digital Imaging and Communications in Medicine format to the stereolithography format using M3D software. The 3DP-RP model was established using the fused deposition modeling technique and the length and diameter of the main screw blade was measured during the simulation. The postoperative femoral neck-shaft angle (NSA), surgery duration, intraoperative and postoperative blood loss, and the duration of hospital stay were recorded and compared with the corresponding values in conventional surgery. No significant differences were observed in mean PFNA size between the implants used and the preoperative planning estimates. It was demonstrated that the 3DP-RP assisted procedure resulted in more effective reduction of the NSA. Furthermore, patients undergoing 3DP-RP experienced a significant reduction in duration of surgery (P<0.01), as well as reductions in intraoperative (P=0.02) and postoperative (P=0.03) blood loss, compared with conventional surgery. At 6 months post-surgery, no cases of hip varus/vague deformities or implant failure were observed in patients that underwent either the 3DP-RP-assisted or conventional procedure. The results of the present study suggest that the 3DP-RP technique is able to create an accurate model of the ITF, which facilitates surgical planning and fracture reduction, thus improving the efficiency of PFNA surgery for ITFs.

  5. AMS 14 C dating controlled records of monsoon and Indonesian throughflow variability from the eastern Indian Ocean of the past 32,000 years

    NASA Astrophysics Data System (ADS)

    Li, Z. Y.; Chen, M. T.; Shi, X.; Liu, S.; Wang, H.

    2015-12-01

    Zi-Ye Li a, Min-Te Chen b, Hou-Jie Wang a, Sheng-Fa Liu c, Xue-Fa Shi ca College of Marine Geosciences, Ocean University of China, Qingdao 266100, P.R. Chinab Institute of Applied Geosciences, National Taiwan Ocean University, Keelung, Taiwan 20224, ROCc First Institute of Oceanography, SOA, Qingdao 266100, P.R. China Indonesian throughflow (ITF) is one of the most important currents responsible for transporting heat and moisture from the western Pacific to the Indian Oceans. The ITF is also well-known as effectively in modulating the global climate change with the interactions among ENSO and Asian monsoons. Here we present an AMS 14C dating controlled sea surface temperature (SST) record from core SO184-10043 (07°18.57'S, 105°03.53'E), which was retrieved from 2171m water depth at a north-south depression located at the southeastern offshore area of Sumatera in the eastern Indian Ocean. Based on our high-resolution SST using Mg/Ca analyses based on planktonic foraminifera shells of Globigerinoides ruber and alkenone index, U k'37-SST, oxygen isotope stratigraphy, and AMC 14C age-controls, our records show that, during the past 32,000 years, the SSTs were decreased which imply weaker ITF during Marine Isotope Stage (MIS) 2 and 3. The weaker UTF may respond to strengthened northeast monsoon during the boreal winter. During 21 to 15ka, the southeast monsoon had been stronger and the northeast monsoon was relatively weaker. During 15 to 8ka, rapid sea level rising may allow the opening of the gateways in the Makassar Strait and Lombok Strait that may have further strengthened the ITF. During the early Holocene, the northeast and southeast monsoons seem to be both strengthened. We will discuss the implications of the hydrographic variability and their age uncertainties in this paper during the meeting.

  6. Marine Isotope Stage (MIS) M2 ( 3.3 Ma) in the southern hemisphere: constraining the climatic drivers of a short-term glaciation event during the Pliocene warm Period.

    NASA Astrophysics Data System (ADS)

    De Vleeschouwer, D.; Auer, G.; Bogus, K.; Groeneveld, J.; Henderiks, J.; Jatiningrum, R. S.; Christensen, B. A.

    2017-12-01

    Global climate was characterized by intriguing climate variability during the Late Pliocene (3.6 to 2.59 Ma): a brief (<100 kyr) but intense glaciation (MIS M2) interrupted the relatively warm climate state around 3.3 Ma. Until today, different hypotheses exist to explain why this glaciation event was so intense, and why the global climate system returned to warm Pliocene conditions relatively quickly. One of these proposed mechanisms is a reduced equator-to-pole heat transfer, in response to a tectonically reduced Indonesian Throughflow (ITF; De Schepper et al., 2014; Karas et al., 2011a, b). However, the scarcity of orbital-scale continuous climate archives in the outflow of the Indonesian Seaway hampers testing this hypothesis. To assess the supposed relationship between mid-Pliocene glaciations and latitudinal heat transport through the Indonesian Throughflow, we constructed a 3-kyr resolution planktonic δ18OG.sacculiferrecord for the 3.9 - 2.7 Ma interval from Site U1463 (18°59'S, 117°37'E; Northwestern Australian Shelf; IODP Expedition 356 "Indonesian Throughflow"). The U1463 oxygen isotope record concurs exceptionally well with the sea surface temperature (SST) record from Site 806 (0°19'N, 159°22'E) in the West Pacific Warm Pool (Wara et al., 2005), even during MIS M2. Hence, Site U1463 suggests an uninterrupted ITF signal during Pliocene glaciations. Surprisingly though, the U1463 δ18OG.sacculifer record exhibits a 0.5‰ offset with the nearby Site 763 record (20°35'S, 112°12'E) around MIS M2. This implies that Site 763, which lies a bit further offshore than U1463, fits better with Indian Ocean SST records (e.g. Site 214; Karas et al., 2009) across MIS M2. In conclusion, the U1463 data reveal that heat-transport through the Indonesian Throughflow did not shut down completely during MIS M2. However, its intensity decreased during MIS M2, causing Site 763 to temporarily reflect an Indian Ocean, rather than an ITF signal. References De Schepper, S. et al. 2014, Earth-Science Reviews, v. 135, p. 83-102. Karas, C. et al. 2009, Nature Geosci, v. 2, no. 6, p. 434-438. Karas, C. et al. 2011a, Earth and Planetary Science Letters, v. 301, no. 1-2, p. 117-124. -, 2011b, Paleoceanography, v. 26. Wara, M. W. et al., 2005, Science, v. 309, no. 5735, p. 758-761.

  7. Variability of Indonesian Throughflow and Borneo Runoff During the Last 14 kyr

    NASA Astrophysics Data System (ADS)

    Hendrizan, Marfasran; Kuhnt, Wolfgang; Holbourn, Ann

    2017-10-01

    We present a high-resolution ( 20 to 100 years temporal resolution) reconstruction of hydrological changes in the Makassar Strait over the last 14 kyr from Core SO217-18517 retrieved off the Mahakam Delta (1°32.198'S, 117°33.756'E; 698 m water depth) during the SO217 Makassar-Java Cruise. Sea surface temperatures, based on Mg/Ca of Globigerinoides ruber and alkenone UK'37, and seawater δ18O reconstructions, based on G. ruber δ18O and Mg/Ca, in combination with sortable silt grain size measurements and X-ray fluorescence (XRF) core scanner derived elemental data provide evidence for increased precipitation during the Bølling-Allerød (BA) and early Holocene and for warmer and more saline surface waters and a decrease in the intensity of the Indonesian Throughflow (ITF) during the Younger Dryas (YD). XRF derived Log (Zr/Rb) records, sortable silt data and increased sedimentation rates indicate decreased winnowing, interpreted as a slowdown of the ITF thermocline flow during the YD. We attribute this decline in ITF intensity to slowdown of the Atlantic meridional overturning circulation during the YD. We suggest that changes in Makassar Strait surface hydrology during this interval of Northern Hemisphere cooling and Southern Hemisphere warming were related to a southward displacement of the Intertropical Convergence Zone.

  8. Oceanic Channel of the IOD-ENSO teleconnection over the Indo-Pacific Ocean

    NASA Astrophysics Data System (ADS)

    Yuan, Dongliang; Wang, Jing; Zhao, Xia; Zhou, Hui; Xu, Tengfei; Xu, Peng

    2017-04-01

    The lag correlations of observations and model simulated data that participate the Coupled Model Intercomparison Project phase-5 (CMIP5) are used to study the precursory teleconnection between the Indian Ocean Dipole (IOD) and the Pacific ENSO one year later through the Indonesian seas. The results suggest that Indonesian Throughflow (ITF) play an important role in the IOD-ENSO teleconnection. Numerical simulations using a hierarchy of ocean models and climate coupled models have shown that the interannual sea level depressions in the southeastern Indian Ocean during IOD force enhanced ITF to transport warm water of the Pacific warm pool to the Indian Ocean, producing cold subsurface temperature anomalies, which propagate to the eastern equatorial Pacific and induce significant coupled ocean-atmosphere evolution. The teleconnection is found to have decadal variability. Similar decadal variability has also been identified in the historical simulations of the CMIP5 models. The dynamics of the inter-basin teleconnection during the positive phases of the decadal variability are diagnosed to be the interannual variations of the ITF associated with the Indian Ocean Dipole (IOD). During the negative phases, the thermocline in the eastern equatorial Pacific is anomalously deeper so that the sea surface temperature anomalies in the cold tongue are not sensitive to the thermocline depth changes. The IOD-ENSO teleconnection is found not affected significantly by the anthropogenic forcing.

  9. NERC Policy 10: Measurement of two generation and load balancing IOS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Spicer, P.J.; Galow, G.G.

    1999-11-01

    Policy 10 will describe specific standards and metrics for most of the reliability functions described in the Interconnected Operations Services Working Group (IOS WG) report. The purpose of this paper is to discuss, in detail, the proposed metrics for two generation and load balancing IOSs: Regulation; Load Following. For purposes of this paper, metrics include both measurement and performance evaluation. The measurement methods discussed are included in the current draft of the proposed Policy 10. The performance evaluation method discussed is offered by the authors for consideration by the IOS ITF (Implementation Task Force) for inclusion into Policy 10.

  10. Nitrogen monoxide decreases iron uptake from transferrin but does not mobilise iron from prelabelled neoplastic cells.

    PubMed

    Richardson, D R; Neumannova, V; Ponka, P

    1995-05-12

    The effect of congeners of nitrogen monoxide (NO) on iron (Fe) uptake from 59Fe-125I-transferrin (Tf) and release of 59Fe from prelabelled cells have been investigated in SK-MEL-28 human melanoma cells, human K562 cells and mouse MDW-4 cells. These studies have been initiated as it has been suggested that the tumoricidal effects of NO may be mediated by its acting to release Fe from cells (Hibbs et al., 1984 Biochem. Biophys. Res. Commun. 123, 716-723; Hibbs et al., 1988 Biochem. Biophys. Res. Commun. 157, 87-94). The nitrosonium ion (NO+) generator, sodium nitroprusside (SNP), decreased 59Fe uptake by melanoma cells to 57% of the control without decreasing 125I-Tf uptake after a 4-h incubation with 59Fe-125-Tf (1.25 microM). Longer incubations up to 24 h decreased 59Fe uptake and also 125I-Tf uptake. Two breakdown products of SNP, ferricyanide and cyanide, had no effect on 59Fe uptake. In addition, photolysis of the SNP solution prevented the inhibition of 59Fe uptake, suggesting that NO was the active agent. Two nitric oxide (NO.) producing agents, 3-morpholinosydnonimine (SIN), and S-nitroso-N-acetylpenicillamine (SNAP), also decreased 59Fe uptake from 59Fe-125I-Tf. Superoxide dismutase increased the efficacy of SIN, and the NO-scavenger, oxyhaemoglobin, prevented the inhibition of 59Fe uptake mediated by SNAP, again suggesting that NO was the active agent. Furthermore, dialysis studies demonstrated that none of the NO-generating agents could remove 59Fe from 59Fe-125I-Tf, suggesting that the decrease in cellular Fe uptake observed was not due to NO releasing Fe from the Fe-binding sites of Tf. Despite the ability of NO-producing agents at inhibiting 59Fe uptake by cells, they could not remove significant amounts of 59Fe from melanoma cells prelabelled with either 59Fe-citrate or 59Fe-125I-Tf. Similar data were obtained using K562 and MDW-4 cells. Interestingly, the NO+ generating agent, SNP, had no effect on [3H]thymidine uptake. However, when SNP was converted to an NO. generator by the addition of 1 mM ascorbate, its effect was similar to the NO. generator, SNAP, markedly reducing [3H]thymidine incorporation to 33% of the control value. The addition of unlabelled diferric Tf (0.625 microM) to SNAP ameliorated its inhibitory effect on cellular [3H]thymidine uptake, suggesting that the interaction of NO. with Fe was of importance in the inhibition observed. The results are discussed in the context of the cytostatic potential of NO via its binding to Fe.

  11. Aircraft Hydraulic Systems Dynamic Analysis. Volume 8. Transient Thermal Analysis (HYTTHA). Computer Program Technical Description

    DTIC Science & Technology

    1977-02-01

    8217P(V, .’f\\,, OCA A, 4 6), V"D(S4, 3LL) X , )lq , 5)\\8, 1( 5) , + ITP ,V0L.L,ACVI;’ D ’k-11AY VA[.IL11:3 + , ’AV./24,/, PLAC/25/,r~ f/26/ ,’A/27/, ITP /28...8217) DT(TFA2)=D( ITF) DT( rPN) =D( irF) DT(’TVF1)=D( ITF) iT(TrVF2) =D( I’rF) L1=L( 1) L2=L( 2) TF( Ll)D( ITP ) TF( L,2)=D( IT F) TC ( L1) =D( ITC) TC( L2)=D...34Gas Dynamics", McGraw Hill, 1958 7. Report GH20-0205-4 "System/360 Scientific Subroutine Package - Version III, Programmer’s Manual," IBM Corp., August

  12. Southern Impact Testing Alliance (SITA)

    NASA Technical Reports Server (NTRS)

    Hubbs, Whitney; Roebuck, Brian; Zwiener, Mark; Wells, Brian

    2009-01-01

    Efforts to form this Alliance began in 2008 to showcase the impact testing capabilities within the southern United States. Impact testing customers can utilize SITA partner capabilities to provide supporting data during all program phases-materials/component/ flight hardware design, development, and qualification. This approach would allow programs to reduce risk by providing low cost testing during early development to flush out possible problems before moving on to larger scale1 higher cost testing. Various SITA partners would participate in impact testing depending on program phase-materials characterization, component/subsystem characterization, full-scale system testing for qualification. SITA partners would collaborate with the customer to develop an integrated test approach during early program phases. Modeling and analysis validation can start with small-scale testing to ensure a level of confidence for the next step large or full-scale conclusive test shots. Impact Testing Facility (ITF) was established and began its research in spacecraft debris shielding in the early 1960's and played a malor role in the International Space Station debris shield development. As a result of return to flight testing after the loss of STS-107 (Columbia) MSFC ITF realized the need to expand their capabilities beyond meteoroid and space debris impact testing. MSFC partnered with the Department of Defense and academic institutions as collaborative efforts to gain and share knowledge that would benefit the Space Agency as well as the DoD. MSFC ITF current capabilities include: Hypervelocity impact testing, ballistic impact testing, and environmental impact testing.

  13. Preauricular infratemporal fossa approach for advanced malignant parotid tumors.

    PubMed

    Leonetti, John P; Benscoter, Brent J; Marzo, Sam J; Borrowdale, Richard W; Pontikis, George C

    2012-09-01

    The aims of this study were to demonstrate the surgical technique involved in the preauricular infratemporal fossa (ITF) approach, outline the clinical indications for use of this technique, and present the results in using this approach in 159 patients with malignant parotid tumors. At the conclusion of this article, the reader should be able to understand the utility of the preauricular infratemporal fossa approach in the management of patients with advanced malignant parotid tumors. This was a retrospective chart review of 159 patients treated at a tertiary care academic medical center following institutional review board approval. A comprehensive medical records review was performed for all patients with malignant parotid tumors who underwent a preauricular ITF approach between July 1988 and July 2010. The most common presenting symptoms were pain and trismus, whereas the presence of a parotid mass and facial paralysis were the most common clinical signs. Mucoepidermoid and adenoid cystic carcinoma accounted for 63% of the tumors, and perineural invasion was found in nearly 71% of the patients. Despite negative surgical margins in 92% of the patients, local or regional tumor recurrence was found in 17% of the cases. The mean follow-up time was 12.8 years. The preauricular ITF approach should be used in the surgical extirpation of advanced malignant parotid neoplasms. This technique provides proximal facial nerve identification, internal carotid artery protection, and negative tumor margins at the skull base. Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.

  14. Expression of Tissue Factor in Epithelial Ovarian Carcinoma Is Involved in the Development of Venous Thromboembolism.

    PubMed

    Sakurai, Manabu; Matsumoto, Koji; Gosho, Masahiko; Sakata, Akiko; Hosokawa, Yoshihiko; Tenjimbayashi, Yuri; Katoh, Takashi; Shikama, Ayumi; Komiya, Haruna; Michikami, Hiroo; Tasaka, Nobutaka; Akiyama-Abe, Azusa; Nakao, Sari; Ochi, Hiroyuki; Onuki, Mamiko; Minaguchi, Takeo; Yoshikawa, Hiroyuki; Satoh, Toyomi

    2017-01-01

    Our 2007 study of 32 patients with ovarian cancer reported the possible involvement of tissue factor (TF) in the development of venous thromboembolism (VTE) before treatment, especially in clear cell carcinoma (CCC). This follow-up study further investigated this possibility in a larger cohort. We investigated the intensity of TF expression (ITFE) and other variables for associations with VTE using univariate and multivariate analyses in 128 patients with epithelial ovarian cancer initially treated between November 2004 and December 2010, none of whom had received neoadjuvant chemotherapy. Before starting treatment, all patients were ultrasonographically screened for VTE. The ITFE was graded based on immunostaining of surgical specimens. Histological types were serous carcinoma (n = 42), CCC (n = 12), endometrioid carcinoma (n = 15), mucinous carcinoma (n = 53), and undifferentiated carcinoma (n = 6). The prevalence of VTE was significantly higher in CCC (34%) than in non-CCC (17%, P = 0.03). As ITFE increased, the frequencies of CCC and VTE increased significantly (P < 0.001 and P = 0.014, respectively). Multivariate analysis identified TF expression and pretreatment dimerized plasmin fragment D level as significant independent risk factors for VTE development. These factors showed particularly strong impacts on advanced-stage disease (P = 0.021). The 2007 cohort was small, preventing multivariate analysis. This study of a larger cohort yielded stronger evidence that the development of VTE in epithelial ovarian cancer may involve TF expression in cancer tissues.

  15. Globalisation, transport and the environment

    DOT National Transportation Integrated Search

    2010-01-01

    OECD and the International Transport Forum (ITF) held a GLobal Forum on Transport and Environment in a Globalising World, 10-12 November 2008 in Guadalajara, Mexico. There were around 200 participants from 23 countries at the global forum, representi...

  16. Sensitivity of equatorial Pacific and Indian Ocean watermasses to the position of the Indonesian Throughflow

    NASA Astrophysics Data System (ADS)

    Rodgers, Keith B.; Latif, Mojib; Legutke, Stephanie

    2000-09-01

    The sensitivity of the thermal structure of the equatorial Pacific and Indian Ocean pycnoclines to a model's representation of the Indonesian Straits connecting the two basins is investigated. Two integrations are performed using the global HOPE ocean model. The initial conditions and surface forcing for both cases are identical; the only difference between the runs is that one has an opening for the Indonesian Straits which spans the equator on the Pacific side, and the other has an opening which lies fully north of the equator. The resulting sensitivity throughout much of the upper ocean is greater than 0.5°C for both the equatorial Indian and Pacific. A realistic simulation of net Indonesian Throughflow (ITF) transport (measured in Sverdrups) is not sufficient for an adequate simulation of equatorial watermasses. The ITF must also contain a realistic admixture of northern and southern Pacific source water.

  17. Mesoscale convective systems and nocturnal rainfall over the West African Sahel: role of the Inter-tropical front

    NASA Astrophysics Data System (ADS)

    Vizy, Edward K.; Cook, Kerry H.

    2018-01-01

    A convection-permitting regional model simulation for August 2006 and observations are evaluated to better understand the diurnal cycle of precipitation over the Sahel. In particular, reasons for a nocturnal rainfall maximum over parts of the Sahel during the height of the West African monsoon are investigated. A relationship between mesoscale convective system (MCS) activity and inter-tropical front (ITF)/dryline dynamics is revealed. Over 90% of the Sahel nocturnal rainfall derives from propagating MCSs that have been associated with topography in earlier studies. In contrast, in this case study, 70-90% of the nocturnal rainfall over the southern Sahel (11°N-14°N) west of 15°E is associated with MCSs that originate less than 1000 km upstream (to the north and east) in the afternoon, in a region largely devoid of significant orography. This MCS development occurs in association with the Sahel ITF, combined with atmospheric pre-conditioning. Daytime surface heating generates turbulent mixing that promotes planetary boundary layer (PBL) growth accompanied by a low-level reversal in the meridional flow. This enhances wind convergence in the low-level moist layer within 2°-3° of latitude of the equatorward side of the ITF. MCSs tend to form when this vertical mixing extends to the level of free convection and is accompanied by a mid-tropospheric African easterly wave disturbance to the east. This synoptic disturbance enhances the vertical wind shear and atmospheric instability over the genesis location. These results are found to be robust across the region.

  18. Mid-Pliocene to Early Pleistocene land and sea surface temperature history of NW Australia based on organic geochemical proxies

    NASA Astrophysics Data System (ADS)

    Smith, R. A.; Castañeda, I. S.; Henderiks, J.; Christensen, B. A.; De Vleeschouwer, D.; Renema, W.; Groeneveld, J.; Bogus, K.; Gallagher, S. J.; Fulthorpe, C.; Expedition 356 Scientists, I.

    2017-12-01

    IODP Expedition 356 Site U1463 is located off the coast of NW Australia, and is sensitive to Indonesian Throughflow (ITF) variability. The ITF is a critical ocean gateway that affects global thermohaline circulation, and regulates the movement of water from the Pacific Ocean into the Indian Ocean. However, despite its importance to the global climate system, few SST reconstructions exist for this region that span the Plio-Pleistocene. Here we investigate both the land and sea-surface temperature (SST) history of NW Australia to constrain ITF variability across the Plio-Pleistocene interval. We apply multiple organic geochemical proxies to this site from 3.4-2.6 Ma, which includes the mid-Pliocene warm period, characterized by slightly higher (2-3°C) global temperatures and similar CO2 concentrations to modern values (e.g. Badger et al. 2013; Bartoli et al., 2011; Dowsett et al., 2009; Hönisch et al., 2009; Pagani et al. 2009; Raymo et al., 1996). SST was reconstructed using TEX86, based on isoprenoid glycerol dialkyl glycerol tetraethers (iGDGTs), and the long-chain diol index (LDI), based on the ratio of diols produced by marine diatoms (Rampen et al., 2012). The Uk'37 index, based on long-chain ketones, was analyzed but cannot be applied as a SST proxy at this site due to the influence of coastal alkenone producers. Additionally, a continental air temperature record was developed using the MBT'5ME proxy, based on branched GDGTs (De Jonge et al., 2014; Weijers et al., 2007). We find that TEX86, LDI and MBT'5Me exhibit similar trends and show relatively warm and stable temperatures from 3.5-2.4 Ma followed by a gradual cooling of 3-4°C from 2.4-1.5 Ma. This cooling corresponds with an arid interval previously identified on the same core by Christensen et al. (2017). Furthermore, we find that the TEX86 record agrees closely with the LR04 global benthic δ18O stack (Lisiecki and Raymo, 2005) and captures glacial/interglacial periods including Marine Isotope Stage M2. Our results help to constrain climatic changes across the mid-Pliocene warm period and aim to improve future climate models and elucidate the role of the ITF in driving global climate variability.

  19. An Analysis on the TEC Variability and Ionospheric Scintillation at Los Alamos, New Mexico Derived from FORTE-Received LAPP Signals

    NASA Astrophysics Data System (ADS)

    Huang, Z.; Roussel-Dupre, R.

    2003-12-01

    The total electron content (TEC) of ionosphere and its electron density irregularities (scintillation) have effects of degradation and disruption on radio signals passed between ground stations and orbiting man-made satellites. With the rapid increase in operational reliance on UHF/VHF satellite communication, it is desirable to obtain understandings of ionosphere TEC variability and scintillation characteristics to improve our ability of predicting satellite communication outages. In this work, data collected from FORTE satellite received LAPP (Los Alamos Portable Pulser) signals during 1998-2002 are used to derive TEC and ionospheric scintillation index at Los Alamos, New Mexico. To characterize in-situ TEC variability at Los Alamos, the FORTE-LAPP derived TECs are analyzed against diurnal, seasonal, solar activity, magnetic storm, and stratospheric warming. The results are also compared with the TEC estimates from the Los Alamos ionospheric transfer function (ITF) implemented with the global ionospheric models (IRI, PIM), and GPS -derived TEC maps. The FORTE-LAPP signals are also analyzed against two important measures of the effect of scintillation on broadband signals, the mean time delay and the time delay jitter. The results are used to examine coherence frequency bandwidth and compared with the predictions from a global scintillation model (WBMOD). The FORTE-LAPP analyzed and WBMOD predicted scintillation characteristics are used to investigate temporal and seasonal behavior of scintillation at Los Alamos.

  20. 15 CFR 2301.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) technologies. Closing date means the date and time which the Administrator sets as the deadline for the receipt.... Nonbroadcast means the distribution of electronic signals by a means other than broadcast technologies. Examples of nonbroadcast technologies are Instructional Television Fixed Service (ITFS), satellite systems...

  1. Regulatory Reform and CATV/TELCO Distance Learning Initiatives in Connecticut.

    ERIC Educational Resources Information Center

    Pietras, Jesse John

    This overview of educational telecommunications and distance learning in Connecticut includes information on the Connecticut Department of Education and the Connecticut Public Television statewide, two-channel, ITFS (instructional television fixed service); the Connecticut Community College system's Community College Instructional Television…

  2. Low-dose intrathecal fluorescein for diagnosis of cerebrospinal fluid rhinorrhea using the scanning fiber endoscope in the human nasal cavities

    NASA Astrophysics Data System (ADS)

    Hou, Vivian W.; Davis, Calvin G.; Davis, Greg E.; Seibel, Eric J.

    2016-03-01

    Intrathecal fluorescein (ITF) enhances detection of cerebrospinal fluid rhinorrhea (CSFR). Clinically administered doses fall in the range of 0.1ml to 0.5ml of 5% to 10% fluorescein (1.3×10-3M to 1.3×10-2M). Though uncommon, significant morbidities associated with high doses of fluorescein have been reported. High concentrations are necessary for white light visual assessment; in contrast, fluorescent imaging enhances signal contrast and requires lower ITF concentrations for visualization. The ultrathin and flexible, multimodal scanning fiber endoscope (SFE) can visualize nanomolar concentrations of fluorescein as pseudocolor over reflectance, video-rate imaging. The application of the SFE for CSFR detection was assessed in a cadaver study. Briefly, 10μM (1×10-5M) fluorescein, 100X-1000X less than the standard clinical dose, was injected intra-cranially into the epidural space through an orbital roof puncture. The resulting rhinorrhea was assessed with a conventional, rigid ENT scope and second with the SFE in both video reflectance and multimodal fluorescent imaging modes. Neither system could visualize the 10μM ITF during white light imaging however the nanomolar sensitive SFE visualized the rhinorrhea during fluorescent imaging. Despite the low concentration used, a target-to-background ratio of 5.6 +/- 2.7 was achieved. To demonstrate SFE guidance of CSFR detection and repair, de-identified patient computed tomography (CT) scans were used to generate 3D printed phantoms. Cases were selected for unique anatomical features and overall clinical difficulty as determined by an experienced ENT clinician (GED). The sensitivity and minimally invasive nature of the SFE provide a unique platform for enhancing diagnosis and monitoring interventions in surgical endoscopic approaches into the sinuses.

  3. Petrous Apex Cholesterol Granulomas: Outcomes, Complications, and Hearing Results From Surgical and Wait-and-Scan Management.

    PubMed

    Grinblat, Golda; Vashishth, Ashish; Galetti, Francesco; Caruso, Antonio; Sanna, Mario

    2017-12-01

    1. To analyze the surgical outcomes in the management of petrous apex cholesterol granulomas (PACG) with a brief literature review.2. To evaluate the importance of wait-and-scan management option. Retrospective review. Quaternary referral center for otology and skull base surgery. Charts of 55 patients with at least 12 months of follow-up were analyzed for demographic, clinical, audiometric, and radiological features. Patients were divided into surgical group (SG) (n = 31) and wait-and-scan (n = 24) (WS) group. Surgical approach was chosen as per hearing status and PACG extension and relation to nearby neurovascular structures and included either drainage by transmastoid-infralabyrinthine approach (TM-IL)/transcanal-infracochlear approach (TC-IC) or resection by infratemporal fossa type B approach (ITF-B). The combination of ITF-B with trans-otic (TO) approach or TO approach solely was used in unserviceable hearing cases. Postoperative outcomes and complications were evaluated in SG. Postoperative symptom relief was observed in 24 patients (77.4%). Diplopia and paresthesia recovered in each case and improvement in headache, dizziness, tinnitus, and hearing loss was observed in 87.1% cases. Serviceable hearing was preserved in 24 of 26 cases. Postoperative complication rate was 32.2% including incidences of profound hearing loss, facial nerve paresis, carotid artery injury and intraoperative CSF leaks. Revision surgery was required in 3 (9.6%) cases, after TM-IL approach. Surgical drainage is preferable to more aggressive resection procedures, with the latter reserved for recurrent lesions or lesions with severe hearing loss/involvement of critical neurovascular structures. ITF-B approach provides adequate cyst and neurovascular control for resection, while avoiding brain retraction. An initial wait-and-scan approach can be used in most patients where symptoms and imaging justify so.

  4. Delivery Systems for Distance Education. ERIC Digest.

    ERIC Educational Resources Information Center

    Schamber, Linda

    This ERIC digest provides a brief overview of the video, audio, and computer technologies that are currently used to deliver instruction for distance education programs. The video systems described include videoconferencing, low-power television (LPTV), closed-circuit television (CCTV), instructional fixed television service (ITFS), and cable…

  5. SPCZ zonal events and downstream influence on surface ocean conditions in the Indonesian Throughflow region

    NASA Astrophysics Data System (ADS)

    Linsley, Braddock K.; Wu, Henry C.; Rixen, Tim; Charles, Christopher D.; Gordon, Arnold L.; Moore, Michael D.

    2017-01-01

    Seasonal surface freshening of the Makassar Strait, the main conduit of the Indonesian Throughflow (ITF), is a key factor controlling the ITF. Here we present a 262 year reconstruction of seasonal sea-surface-salinity variability from 1742 to 2004 Common Era by using coral δ18O records from the central Makassar Strait. Our record reveals persistent seasonal freshening and also years with significant truncations of seasonal freshening that correlate exactly with South Pacific Convergence Zone (SPCZ) zonal events >4000 km to the east. During these events, the SPCZ dramatically rotates 15° north to near the equator and stronger westward flowing South Pacific boundary currents force higher-salinity water through the Makassar Strait in February-May halting the normal seasonal freshening in the strait. By these teleconnections, our Makassar coral δ18O series provides the first record of the recurrence interval of these zonal SPCZ events and demonstrates that they have occurred on a semiregular basis since the mid-1700s.

  6. NREL and SDG&E Collaboration to Support SDG&E Grid and Storage Efforts: Cooperative Research and Development Final Report, CRADA Number CRD-14-562

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Baggu, Murali

    2017-01-01

    This project will enable effective utilization of high penetration of photovoltaics (PV) in islanded microgrids, increasing overall system efficiency, decreased fuel costs and resiliency of the overall system to help meet the SunShot goals of enhancing system integration methods to increase penetration of PV. National Renewable Energy Laboratory (NREL) will collaborate with San Diego Gas & Electric (SDG&E) to provide research and testing support to address their needs in energy storage sizing and placement, Integrated Test Facility (ITF) development, Real Time Digital Simulator (RTDS) Modeling and simulation support at ITF, Visualization and Virtual connection to Energy Systems Integration Facility (ESIF),more » and microgrid simulation and testing areas. Specifically in this project a real microgrid scenario with high penetration of PV (existing in SDG&E territory) is tested in the ESIF laboratory. Multiple control cases for firming PV using storage in a microgrid scenario will be investigated and tested in the laboratory setup.« less

  7. Analysis of turbulent mixing in Dewakang Sill, Southern Makassar Strait

    NASA Astrophysics Data System (ADS)

    Risko; Atmadipoera, A. S.; Jaya, I.; Sudjono, E. H.

    2017-01-01

    Dewakang Sill is located in southern Makassar Strait, conveying major path of Indonesian Throughflow (ITF), as a confluence region of different water masses, such as salty Pacific water and fresh Java Sea water. Its depth is about 680 m which blocks the ITF flow below this depth into Flores Sea. This research aimed to estimate turbulent mixing in the Dewakang Sill by applying Thorpe analysis using 24 hours “yoyo” CTD data sets, acquired from MAJAFLOX Cruise in August 2015. The results showed that stratification of water masses is dominated by Pacific water origin. Those are North Pacific Subtropical thermocline and Intermediate water masses. Mean dissipation of turbulent kinetic energy (ɛ) and turbulent vertical diffusivity (Kρ ) value in the Dewakang Sill are of O(1.08 × 10-6)Wkg-1, and O(2.84 × 10-4) m2s-1 respectively. High correlation between epsilon and internal waves oscillation suggested that internal tidal waves activities are the major forcing for turbulent mixing in the study area.

  8. Partnerships through Innovative Telecommunications at California State University, Chico.

    ERIC Educational Resources Information Center

    Meuter, Ralph F.; And Others

    California State University (CSU), Chico, has used its relatively isolated location to develop an extensive educational system known as "Instructional Television for Students" (ITFS). Currently, the university is launching plans for new partnerships utilizing satellite technology for the delivery of educational programs. Over the years,…

  9. U.S. EPA, Pesticide Product Label, , 01/12/1973

    EPA Pesticide Factsheets

    2011-04-21

    , #J ;j .i. I'; : I :l :. j :qJ $-J =':ITI'it j', ,~~ L;'tf1 T'J ;-~'tt"n : r~rf)\\ "l P"h,' ''' n 11:1" t'I'~ .,.y~ . ~ r; ~',, _ •.... f "",) . 1:' 'It(F.~~ ;~R f:!i ~~-'- ...

  10. An Introduction for Distance Educators [and] Five Essential Factors Every Administrator Needs To Know about Integrated Telecommunications Infrastructures.

    ERIC Educational Resources Information Center

    Saba, Farhad; Mahon, J. Michael

    1999-01-01

    Discusses telecommunications developments that are affecting distance educators. Topics include bandwidth; educational radio and television; instructional television-fixed services (ITFS); cable television; communication satellites; computers; digital telecommunications; the Internet; other protocols; future systems; telephone switches and…

  11. 47 CFR Alphabetical Index - Part 74

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Signal booster stations 74.985 Transmission standards 74.938 Wireless cable use 74.990 L Land mobile... Transmissions, Permissible (Low Power Auxiliaries) 74.831 Transmitter power (Remote Pickup) 74.461 Transmitters... 74.451 TV Auxiliaries 74.655 Lw Power Auxiliaries 74.851 ITFS 74.952 FM Translators/Boosters 74.1250...

  12. FCC, CATV, ETV, and ITFS.

    ERIC Educational Resources Information Center

    Schwartz, Louis; Woods, Robert A.

    Actions taken in 1970 by the Federal Communications Commission (FCC) are reviewed and discussed in this paper. These actions include amendment of educational broadcast rules for the first time in 17 years, decisions in the area of educational programing, a decision regarding the ultra high frequency (UHF)-land mobile dilemma, and a promise to…

  13. In Vitro Vascular Cell Adhesion and Proliferation on Alkaline Degraded Poly-lactic/glycolic Acid Polymers

    DTIC Science & Technology

    2002-04-01

    implanted gr~itf often leads to intimal hyperplasia which has resulted in occlusion of the regenerated vascular tissue [1, 2]. Since an endothelial... fibrovascular tissue ingrowth [I]. Clearly, the inability of poly(lactic acid) containing polymers to promote sufficient endothelialization presents serious

  14. Developing and Managing a Multi-Modal Distance Learning Program in the Two-Year College.

    ERIC Educational Resources Information Center

    Hyatt, Sue Y.

    Chattanooga State Technical Community College (CSTCC), in Tennessee, offers distance learning courses through Instructional Television Fixed Service (ITFS) broadcast, through broadcasts of a local public television affiliate station, and through video cassette checkout/mailout. By the end of fiscal year 1991-92, over 2,500 students had enrolled in…

  15. Satellite Synthetic Aperture Radar Detection of Ocean Internal Waves in the South China Sea

    DTIC Science & Technology

    2006-09-30

    waves will occur and what effects they will have on the hydrodynamic and acoustic environment. This project focuses on the use of remotely sensed...variability of the ITF and its associated heat and freshwater flux exported into the Indian Ocean. REFERENCES Boyer, T., and S. Levites , Quality

  16. An inulin-type fructan enhances calcium absorption primarily via an effect on colonic absorption in humans

    USDA-ARS?s Scientific Manuscript database

    Calcium absorption efficiency and bone mineral mass are increased in adolescents who regularly consume inulin-type fructans (ITF). The mechanism of action in increasing absorption is unknown but may be related to increased colonic calcium absorption. We conducted a study in young adults designed to ...

  17. Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism

    PubMed Central

    Jeong, Mark Y.; Lin, Ying H.; Wennersten, Sara A.; Demos-Davies, Kimberly M.; Cavasin, Maria A.; Mahaffey, Jennifer H.; Monzani, Valmen; Saripalli, Chandrasekhar; Mascagni, Paolo; Reece, T. Brett; Ambardekar, Amrut V.; Granzier, Henk L.; Dinarello, Charles A.; McKinsey, Timothy A.

    2018-01-01

    There are no approved drugs for the treatment of heart failure with preserved ejection fraction (HFpEF), which is characterized by left ventricular (LV) diastolic dysfunction. We demonstrate that ITF2357 (givinostat), a clinical-stage inhibitor of histone deacetylase (HDAC) catalytic activity, is efficacious in two distinct murine models of diastolic dysfunction with preserved EF. ITF2357 blocked LV diastolic dysfunction due to hypertension in Dahl salt-sensitive (DSS) rats and suppressed aging-induced diastolic dysfunction in normotensive mice. HDAC inhibitor–mediated efficacy was not due to lowering blood pressure or inhibiting cellular and molecular events commonly associated with diastolic dysfunction, including cardiac fibrosis, cardiac hypertrophy, or changes in cardiac titin and myosin isoform expression. Instead, ex vivo studies revealed impairment of cardiac myofibril relaxation as a previously unrecognized, myocyte-autonomous mechanism for diastolic dysfunction, which can be ameliorated by HDAC inhibition. Translating these findings to humans, cardiac myofibrils from patients with diastolic dysfunction and preserved EF also exhibited compromised relaxation. These data suggest that agents such as HDAC inhibitors, which potentiate cardiac myofibril relaxation, hold promise for the treatment of HFpEF in humans. PMID:29437146

  18. Characterization of early and late endocytic compartments of the transferrin cycle. Transferrin receptor antibody blocks erythroid differentiation by trapping the receptor in the early endosome.

    PubMed

    Killisch, I; Steinlein, P; Römisch, K; Hollinshead, R; Beug, H; Griffiths, G

    1992-09-01

    We describe a detailed morphological characterization of the endocytic pathway in differentiating chicken erythroblasts transformed by a temperature-sensitive mutant of avian erythroblastosis virus (AEV). These cells express high levels of transferrin receptors (TfR) when induced to differentiate at 42 degrees C. Biochemical analysis showed that most (approximately 90%) of the internalized 125I-Tf recycled within approximately 30 min while a smaller fraction of 125I-Tf required up to 2 h for recycling. By immunocytochemistry, the bulk of Tf and TfR was localized at the plasma membrane and in tubuloreticular early endosomes. This structure contained coated buds that labelled with an antibody specific for the clathrin light chain. Decreasing amounts of both Tf and TfR were detected in two distal compartments, spherical endosome vesicles resembling multivesicular bodies and the prelysosomal compartment (PLC) enriched in cation-independent mannose 6-phosphate receptor. As shown by fluorescent (FITC-Tf) labelling of living cells, the movement of Tf/TfR complex into these late structures was accompanied by a significant drop in pH from about 6, the value displayed by early endosomes, to values below pH 5.0. Since no detectable 125I-Tf degradation was observed during a 4 h period we believe that the Tf/TfR detected in these late endocytic structures avoids degradation and recycles back to the cell surface. The addition of an anti-TfR monoclonal antibody to the culture medium of these cells blocks their differentiation. Under this condition the antibody-TfR complex was trapped in an early endosome compartment that enlarged to more than twice its normal size. However, this condition did not affect the transport kinetics of horseradish peroxidase from the medium to the PLC.

  19. Indonesian Throughflow drove Australian climate from humid Pliocene to arid Pleistocene

    NASA Astrophysics Data System (ADS)

    Christensen, B. A.; Renema, W.; Henderiks, J.; De Vleeschouwer, D.; Groeneveld, J.; Castañeda, I. S.; Reuning, L.; Bogus, K.; Auer, G.; Ishiwa, T.; McHugh, C.; Gallagher, S. J.; Fulthorpe, C.; Expedition 356 Scientists, I.

    2016-12-01

    Our understanding of the onset of aridity in Australia and associated mechanisms is limited by the availability of long, continuous climate archives, particularly for the NW shelf in the Pliocene. Five sites were cored and logged on IODP Expedition 356, western Australian margin. Analysis of the natural gamma ray (NGR) suite of downhole logs, provide insights to the timing and rate of climate change. NGR data provide an outstanding tool to assess continental humidity (K%) and aridity (Th/K, Uppm); interpretations are supported with clay mineral data. We show progressive constriction of the Indonesian Throughflow (ITF) and the emerging Maritime Continent drove Australian climate to become drier and more variable. We identify 3 intervals of latest Miocene through early Pleistocene change: sudden onset of humidity at 5.5 Ma (Humid Interval), followed by decreased humidity (Transition Interval) and establishment of the NW dust pathway (Arid Interval) at 2.3 Ma. The Humid Interval is associated with the Western Pacific Warm Pool (WPWP) expansion west to the South China Sea and higher Indian Ocean SSTs. Our study of the NW region confirms wetter climates ringed the arid center during the early Pliocene. Reduced moisture availability began at 3.3 Ma, coincident with cooling in the WPWP and elsewhere, global atmospheric circulation constriction and Indian Ocean subsurface freshening and cooling, a direct response to ITF constriction. Greatest aridity and the onset of the modern dust pathway, documented in Th/K and Uppm logs beginning 2.3 Ma, is coincident with orbitally- controlled climatic change, and reorganization of Indian Ocean circulation. Our data indicate Australian climate is driven by tectonic and oceanographic changes in the ITF. Such changes altered regional atmospheric moisture transport and Indian Ocean circulation patterns and led to a shift from Pacific to Indian Ocean influence on theNW Australian climate, well after the intensification of northern hemisphere glaciation. We conclude that the Maritime Continent is the switchboard modulating teleconnections between monsoonal and glacial climate systems.

  20. On Campus Benefits from an Innovative Extended Campus Library Services Program.

    ERIC Educational Resources Information Center

    Cookingham, Robert M.

    Utilizing the experience of the library of California State University (CSU), Chico in servicing off-campus students who receive instruction via a two-way audio and one-way video communication network called the Instructional Television Fixed Service (ITFS), this paper examines the role that extended campus library services can play in the process…

  1. University Television in Northeastern California: A Partial Solution for the Future?

    ERIC Educational Resources Information Center

    Urbanowicz, Charles F.

    The Instructional Television Fixed Service (ITFS) closed circuit delivery system, which became operational on the California State University (CSU), Chico campus in 1975, has offered 61 courses (up to 13 per semester) with up to 27 transmission hours per week to campus students and people at six surrounding Regional Learning Centers (RLC). CSU,…

  2. Report on Beryllium Strength Experiments Conducted at the TA-55 40 mm Impact Test Facility, Fiscal Year 2017

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Anderson, William Wyatt; Hollowell, Benjamin Charles; Martinez, Todd P.

    A series of experiments is currently in progress at eth 40 mm Impact Test Facility (ITF), located at TA-55, to understand the strength behavior of Beryllium metal at elevated temperature and pressure. In FY 2017, three experiments were conducted as a part of this project.

  3. One Week of Educational Television. Number Six. March 9-15, 1970.

    ERIC Educational Resources Information Center

    Rockman, Saul; Hudson, Robert B.

    In this sixth survey of educational television in the United States, 187 UHF-VHF educational television (ETV) stations, 27 ITFS (Instructional Television Fixed Service) systems, and 35 CCTV (closed circuit television) systems reported on their operating policies and on their programming during the week of March 9-15, 1970. The amount and kind of…

  4. Development of a Run Time Math Library for the 1750A Airborne Microcomputer.

    DTIC Science & Technology

    1985-12-01

    premiue CWUTLDK Is R: Integer :a 0; 0: Integer :ul; LNMM: UEM; -Compute the Lado (alpii) for J In 0..Ol.K-1) loop Itf 0(14 1)/ 0. 0...ORGANIZATION (If appiicable) * School of Engineering AFIT/ ENC 6c. ADDRESS (City, State and ZIP Code) 7b. ADDRESS (City. State and ZIP Code) Air Force

  5. Young adolescents who respond to an inulin-type fructan substantially increase total absorbed calcium and daily calcium accretion to the skeleton

    USDA-ARS?s Scientific Manuscript database

    Calcium absorption and whole-body bone mineral content are greater in young adolescents who receive 8 g/d of Synergy, a mixture of inulin-type fructans (ITF), compared with those who received a maltodextrin control. Not all adolescents responded to this intervention, however. We evaluated 32 respond...

  6. The Development of Electronic Distance Education Delivery Systems in the United States. Recurring and Emerging Themes in History and Philosophy of Education.

    ERIC Educational Resources Information Center

    Buckland, Michael; Dye, Charles M.

    This paper presents a history of electronic distance education in the United States. Three broad categories of delivery systems are described: (1) over-the-air open circuit systems such as VHF-UHF stations, microwave, instructional television fixed service (ITFS), communications satellites, and educational radio and television; (2)…

  7. Point-source helicity injection for ST plasma startup in Pegasus

    NASA Astrophysics Data System (ADS)

    Redd, A. J.; Battaglia, D. J.; Bongard, M. W.; Fonck, R. J.; Schlossberg, D. J.

    2009-11-01

    Plasma current guns are used as point-source DC helicity injectors for forming non-solenoidal tokamak plasmas in the Pegasus Toroidal Experiment. Discharges driven by this injection scheme have achieved Ip>= 100 kA using Iinj<= 4 kA. They form at the outboard midplane, transition to a tokamak-like equilibrium, and continue to grow inward as Ip increases due to helicity injection and outer- PF induction. The maximum Ip is determined by helicity balance (injection rate vs resistive dissipation) and a Taylor relaxation limit, in which Ip√ITF Iinj/w, where w is the radial thickness of the gun-driven edge. Preliminary experiments tentatively confirm these scalings with ITF, Iinj, and w, increasing confidence in this simple relaxation model. Adding solenoidal inductive drive during helicity injection can push Ip up to, but not beyond, the predicted relaxation limit, demonstrating that this is a hard performance limit. Present experiments are focused on increasing the injection voltage (i.e., helicity injection rate) and reducing w. Near-term goals are to further test scalings predicted by the simple relaxation model and to study in detail the observed bursty n=1 activity correlated with rapid increases in Ip.

  8. Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury

    PubMed Central

    Wang, Yuhua; Liu, Yanlong; Sidhu, Anju; Ma, Zhenhua; McClain, Craig

    2012-01-01

    Endotoxemia is a contributing cofactor to alcoholic liver disease (ALD), and alcohol-induced increased intestinal permeability is one of the mechanisms of endotoxin absorption. Probiotic bacteria have been shown to promote intestinal epithelial integrity and protect barrier function in inflammatory bowel disease (IBD) and in ALD. Although it is highly possible that some common molecules secreted by probiotics contribute to this action in IBD, the effect of probiotic culture supernatant has not yet been studied in ALD. We examined the effects of Lactobacillus rhamnosus GG culture supernatant (LGG-s) on the acute alcohol-induced intestinal integrity and liver injury in a mouse model. Mice on standard chow diet were supplemented with supernatant from LGG culture (109 colony-forming unit/mouse) for 5 days, and one dose of alcohol at 6 g/kg body wt was administered via gavage. Intestinal permeability was measured by FITC-FD-4 ex vivo. Alcohol-induced liver injury was examined by measuring the activity of alanine aminotransferase (ALT) in plasma, and liver steatosis was evaluated by triglyceride content and Oil Red O staining of the liver sections. LGG-s pretreatment restored alcohol-induced reduction in ileum mRNA levels of claudin-1, intestine trefoil factor (ITF), P-glycoprotein (P-gp), and cathelin-related antimicrobial peptide (CRAMP), which play important roles on intestinal barrier integrity. As a result, LGG-s pretreatment significantly inhibited the alcohol-induced intestinal permeability, endotoxemia and subsequently liver injury. Interestingly, LGG-s pretreatment increased ileum mRNA expression of hypoxia-inducible factor (HIF)-2α, an important transcription factor of ITF, P-gp, and CRAMP. These results suggest that LGG-s ameliorates the acute alcohol-induced liver injury by promoting HIF signaling, leading to the suppression of alcohol-induced increased intestinal permeability and endotoxemia. The use of bacteria-free LGG culture supernatant provides a novel strategy for prevention of acute alcohol-induced liver injury. PMID:22538402

  9. Naval Research Laboratory 1983 Review.

    DTIC Science & Technology

    1983-01-01

    Kennedy A realistic earth model improves radio wave propagation theory 50 Design of High - Frequency Networks for Tactical Communication Dennis J. Baker...This signal is ing approximately a 3 kHz bandwidth) such as a pulse train if the speech is voiced (vowel high frequency (HF) channels and public tele...developed a design concept for a high quickly and reliably broadcast messages to all frequency (HF) intratask force (ITF) communi- cluster members

  10. Determining the energetic and informational components of speech-on-speech masking

    PubMed Central

    Kidd, Gerald; Mason, Christine R.; Swaminathan, Jayaganesh; Roverud, Elin; Clayton, Kameron K.; Best, Virginia

    2016-01-01

    Identification of target speech was studied under masked conditions consisting of two or four independent speech maskers. In the reference conditions, the maskers were colocated with the target, the masker talkers were the same sex as the target, and the masker speech was intelligible. The comparison conditions, intended to provide release from masking, included different-sex target and masker talkers, time-reversal of the masker speech, and spatial separation of the maskers from the target. Significant release from masking was found for all comparison conditions. To determine whether these reductions in masking could be attributed to differences in energetic masking, ideal time-frequency segregation (ITFS) processing was applied so that the time-frequency units where the masker energy dominated the target energy were removed. The remaining target-dominated “glimpses” were reassembled as the stimulus. Speech reception thresholds measured using these resynthesized ITFS-processed stimuli were the same for the reference and comparison conditions supporting the conclusion that the amount of energetic masking across conditions was the same. These results indicated that the large release from masking found under all comparison conditions was due primarily to a reduction in informational masking. Furthermore, the large individual differences observed generally were correlated across the three masking release conditions. PMID:27475139

  11. A Reversal of Decadal Trends in the Equatorial and North Indian Ocean

    NASA Astrophysics Data System (ADS)

    Thompson, P. R.; Merrifield, M. A.; McCreary, J. P., Jr.; Firing, E.; Piecuch, C. G.

    2016-02-01

    Sea level and upper ocean temperature trends in the Equatorial and North Indian Ocean (ENIO) reversed sign shortly after the turn of the century. The trend reversal is spatially coherent and characterized by subsurface cooling during 1993-2002 followed by subsurface warming during 2003-2012. Here we explore the dynamics and forcing of the decadal trend reversal, with a particular emphasis on the role of the Indian Ocean cross-equatorial cell (CEC) and anomalies transmitted from the Pacific basin to the ENIO via the Indonesian Throughflow (ITF). An examination of reanalysis wind-stress fields suggest that forcing of the CEC is enhanced during the cooling phase of the decadal fluctuation, which may account for the cooling trend below 100m in the ENIO during the first decade. In contrast, the subsurface warming during the second decade occurs at thermocline levels, which suggests a deepening of the thermocline during this period. Enhanced Pacific tradewinds since the early 1990s result in a deepening thermocline in the western tropical Pacific (WTP), which may be transmitted to the Indian Ocean basin via the ITF. We present results from simple model experiments that assess the potential for thermocline anomalies originating in the WTP to account for the deepening thermocline in the ENIO during the warming phase of the decadal fluctuation.

  12. The Prospective Health Assessment of Cataract Patients’ Ocular Surface (PHACO) study: the effect of dry eye

    PubMed Central

    Trattler, William B; Majmudar, Parag A; Donnenfeld, Eric D; McDonald, Marguerite B; Stonecipher, Karl G; Goldberg, Damien F

    2017-01-01

    Purpose To determine the incidence and severity of dry eye as determined by the International Task Force (ITF) scale in patients being screened for cataract surgery. Patients and methods This was a prospective, multi-center, observational study of 136 patients, at least 55 years of age, who were scheduled to undergo cataract surgery. The primary outcome measure was the incidence of dry eye as evaluated by grade on the ITF scale and secondary outcome measures include tear break-up time (TBUT), ocular surface disease index score, corneal staining with fluorescein, conjunctival staining with lissamine green, and a patient questionnaire to evaluate symptoms of dry eye. Results Mean patient age was 70.7 years. A total of 73.5% of patients were Caucasian and 50% were female. Almost 60% had never complained of a foreign body sensation; only 13% complained of a foreign body sensation half or most of the time. The majority of patients (62.9%) had a TBUT ≤5 seconds, 77% of eyes had positive corneal staining and 50% of the eyes had positive central corneal staining. Eighteen percent had Schirmer’s score with anesthesia ≤5 mm. Conclusion The incidence of dry eye in patients scheduled to undergo cataract surgery in a real-world setting is higher than anticipated. PMID:28848324

  13. [A pediatric case of hydatid cyst in the infratemporal fossa].

    PubMed

    Hiroual, A; Elbouihi, M; Fawzi, S; Lahmiti, S; Aimmadeddine, S; Mansouri-Hattab, N

    2014-06-01

    Hydatid cyst or disease is an anthropozoonosis due to the development of the larval form of the taenia Echinococcus granulosus in humans. It is endemic in Morocco. The location of a hydatid cyst in the infratemporal fossa (ITF) is extremely rare. The authors report a pediatric case. An 11 year old child was admitted to hospital with a history of left latero-facial swelling gradually increasing in volume for 2 months, CT scan of the face revealed a cystic formation of 7 cm diameter sitting at the left ITF, hydatid serology was negative. A transzygomatic approach allowed the excision of the cyst. The histopathological examination of the resected specimen confirmed the diagnosis of hydatid cyst. The location at the infratemporal fossa of an expansive process such as hydatid cyst in children may have a particular impact on adjacent structures and a more meaningful clinical expression. The rate of growth of hydatid cysts is highly variable and ranges from 1 to 5 cm a year. Hydatid serology is often negative. CT examination is the gold-standard radiological examination. Surgical removal of the hydatid cyst is the most effective treatment. The transzygomatic approach allowed a sufficient access to the cyst and a good quality of excision. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  14. Sparseness- and continuity-constrained seismic imaging

    NASA Astrophysics Data System (ADS)

    Herrmann, Felix J.

    2005-04-01

    Non-linear solution strategies to the least-squares seismic inverse-scattering problem with sparseness and continuity constraints are proposed. Our approach is designed to (i) deal with substantial amounts of additive noise (SNR < 0 dB); (ii) use the sparseness and locality (both in position and angle) of directional basis functions (such as curvelets and contourlets) on the model: the reflectivity; and (iii) exploit the near invariance of these basis functions under the normal operator, i.e., the scattering-followed-by-imaging operator. Signal-to-noise ratio and the continuity along the imaged reflectors are significantly enhanced by formulating the solution of the seismic inverse problem in terms of an optimization problem. During the optimization, sparseness on the basis and continuity along the reflectors are imposed by jointly minimizing the l1- and anisotropic diffusion/total-variation norms on the coefficients and reflectivity, respectively. [Joint work with Peyman P. Moghaddam was carried out as part of the SINBAD project, with financial support secured through ITF (the Industry Technology Facilitator) from the following organizations: BG Group, BP, ExxonMobil, and SHELL. Additional funding came from the NSERC Discovery Grants 22R81254.

  15. The Numerical Solution of Compressible Fluid Flow Problems

    DTIC Science & Technology

    1944-05-01

    thermodynamic relation dh = Tds + dp (33) and equation (3l) for the rotation of the fluid element he comes ön j t3„, _ 1 ! T 08 q V On...U7 /Sf .»IT /itf\\ ,111 •I’l • 0 mj a 510 »l»0 • «-I 0*« » 0 MO 0.0 - 0 .1 Oil f ^ ,w /S-, f« ^, s flj 4T oj

  16. Water mass transformation along the Indonesian throughflow in an OGCM

    NASA Astrophysics Data System (ADS)

    Koch-Larrouy, Ariane; Madec, Gurvan; Blanke, Bruno; Molcard, Robert

    2008-11-01

    The oceanic pathways connecting the Pacific Ocean to the Indian Ocean are described using a quantitative Lagrangian method applied to Eulerian fields from an ocean general circulation model simulation of the Indonesian seas. The main routes diagnosed are in good agreement with those inferred from observations. The secondary routes and the Pacific recirculation are also quantified. The model reproduces the observed salt penetration of subtropical waters from the South Pacific, the homohaline stratification in the southern Indonesian basins, and the cold fresh tongue which exits into the Indian Ocean. These particular water mass characteristics, close to those observed, are obtained when a tidal mixing parameterization is introduced into the model. Trajectories are obtained which link the water masses at the entrance and at the exit of the Indonesian throughflow (ITF), and the mixing along each trajectory is quantified. Both the ITF and the Pacific recirculation are transformed, suggesting that the Indonesian transformation affects both the Indian and Pacific stratification. A recipe to form Indonesian water masses is proposed. We present three major features of the circulation that revisit the classical picture of the ITF and its associated water mass transformation, while still being in agreement with observations. Firstly, the homohaline layer is not a result of pure isopycnal mixing of the North Pacific Intermediate Water and South Pacific Subtropical Water (SPSW) within the Banda Sea, as previously thought. Instead, the observed homohaline layer is reproduced by the model, but it is caused by both isopycnal mixing with the SPSW and a dominant vertical mixing before the Banda Sea with the NPSW. This new mechanism could be real since the model reproduces the SPSW penetration as observed. Secondly, the model explains why the Banda Sea thermocline water is so fresh compared to the SPSW. Until now, the only explanation was a recirculation of the freshwater from the western route. The model does not reproduce this recirculation but instead shows strong mixing of the SPSW within the Halmahera and Seram Seas, which erodes the salinity maximum so that its signature is not longer perceptible. Finally, this work highlights the key role of the Java Sea freshwater. Even though its annual net mass contribution is small, its fresh salinity contribution is highly significant and represents the main reason why the Pacific salinity maxima are eroded.

  17. Simulated and Observed Circulation in the Indonesian Seas: 1/12 deg Global HYCOM and the INSTANT Observations

    DTIC Science & Technology

    2010-04-14

    for inter- basin exchange, including the net throughflow transport. The simulated total ITF transport (-13.4 Sv) is similar to the observational...May 2004 and 2005, November 2004, 2005 and 2006) appear to be associated with coastally-trapped Kelvin waves propagating eastward along Sumatra coast...in global HYCOM, this submerged multi-passage plateau causes the flow to separate into three branches, an eastern and central branch that feeds the

  18. Platinum Group Coatings for Refractory Metals

    DTIC Science & Technology

    1984-06-01

    temperatures and deposition was very slow. We decided to try iridium hexaflouride, Siridium trichloride hydrate, iridiuw carbonyl and tris-acetyl acetonato...T:*ouu sue. CO. Rhenium Refractory Metals 03 1 d.pRsiý C rg Iridium Coatings 2i 8 bapo i 10. ASSTRACT Won#~.. on mov ofot~sfte.. iad k.dhItfV by b...b q Oxidation resistant coatings of iridium on rhenium substrates have been produced by chemical vapor deposition from an iridium acetyl acetonate

  19. Design of process parameters for the incremental tube forming (ITF) by FEM to control product properties

    NASA Astrophysics Data System (ADS)

    Nazari, Esmaeil; Löbbe, Christian; Gallus, Stefan; Izadyar, S. Ahmad; Tekkaya, A. Erman

    2018-05-01

    The incremental tube forming (ITF) is a process combination of the kinematic tube bending and spinning to shape high strength and tailored tubes with variable diameters and thicknesses. In contrast to conventional bending methods, the compressive stress superposition by the spinning process facilitates low bending stresses, so that geometrical errors are avoided and the shape accuracy is improved. The study reveals the interaction of plastic strains of the rolling and bending process through an explicit FEM investigation. For this purpose, the three-dimensional machine set-up is discretized and modeled in terms of the fully disclosed spinning process during the gradual deflection of the tube end for bending. The analysis shows that, depending on the forming tool shape, the stress superposition is accompanied by high plastic strains. Furthermore, this phenomenon is explained by the three dimensional normal and shear strains during the incremental spinning. Analyzing the strains history also shows a nonlinearity between the strains by bending and spinning. It is also shown that process parameters like rotational velocity of the spinning rolls have a huge influence on the deformation pattern. Finally, the method is used for the manufacturing of an example product, which reveals the high process flexibility. In one clamp a component with a graded wall thickness and outside diameter along the longitudinal axis is produced.

  20. Single-Staged Improved Tubularized Preputial/Penile Skin Flap Urethroplasty for Obliterated Anterior Urethral Stricture: Long-Term Results.

    PubMed

    Xue, Jing-Dong; Xie, Hong; Fu, Qiang; Feng, Chao; Guo, Hui; Xu, Yue-Min

    2016-01-01

    To present an improved tubularized flap (ITF) technique and report the outcome of single-stage urethroplasty using preputial/penile skin flaps (PSFs) for the treatment of obliterative anterior urethral strictures (AUSs). From January 2000 to June 2012, 42 cases of obliterative AUS (3-14 cm, mean 6.38 cm) with urethral plate unsalvageable were treated using PSF-ITF urethroplasty including longitudinal skin flap, circular island flap, L-flap, Q-flap. Patients were divided into 3 groups: pendulous urethral stricture (Group A), bulbar urethral stricture (Group B) and panurethral strictures (Group C). Patients were followed up by uroflowmetry, urethrography and ureteroscope when necessary. The mean follow-up in these patients was 65 months (range 36 months-15 years). The primary success rates at 3-year follow-up were 75, 75 and 60% for Groups A, B and C, respectively. The overall success rates were 85, 83 and 70% with the remedial measure of a single visual internal urethrotomy at 3-year follow-up. A total 60% of the patients in the study completed more than 5 years of follow-up with no additional recurrence. Improved tubularized preputial/PSF urethroplasty with relatively high overall satisfaction is a novel technique for treatment of AUS when there is inadequate urethral plate or obliterative defects. © 2016 S. Karger AG, Basel.

  1. Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase–dependent DC functions and regulates experimental graft-versus-host disease in mice

    PubMed Central

    Reddy, Pavan; Sun, Yaping; Toubai, Tomomi; Duran-Struuck, Raimon; Clouthier, Shawn G.; Weisiger, Elizabeth; Maeda, Yoshinobu; Tawara, Isao; Krijanovski, Oleg; Gatza, Erin; Liu, Chen; Malter, Chelsea; Mascagni, Paolo; Dinarello, Charles A.; Ferrara, James L.M.

    2008-01-01

    Histone deacetylase (HDAC) inhibitors are antitumor agents that also have antiinflammatory properties. However, the mechanisms of their immunomodulatory functions are not known. We investigated the mechanisms of action of 2 HDAC inhibitors, suberoylanilide hydroxamic acid (SAHA) and ITF 2357, on mouse DC responses. Pretreatment of DCs with HDAC inhibitors significantly reduced TLR-induced secretion of proinflammatory cytokines, suppressed the expression of CD40 and CD80, and reduced the in vitro and in vivo allostimulatory responses induced by the DCs. In addition, injection of DCs treated ex vivo with HDAC inhibitors reduced experimental graft-versus-host disease (GVHD) in a murine allogeneic BM transplantation model. Exposure of DCs to HDAC inhibitors increased expression of indoleamine 2,3-dioxygenase (IDO), a suppressor of DC function. Blockade of IDO in WT DCs with siRNA and with DCs from IDO-deficient animals caused substantial reversal of HDAC inhibition–induced in vitro suppression of DC-stimulated responses. Direct injection of HDAC inhibitors early after allogeneic BM transplantation to chimeric animals whose BM-derived cells lacked IDO failed to protect from GVHD, demonstrating an in vivo functional role for IDO. Together, these data show that HDAC inhibitors regulate multiple DC functions through the induction of IDO and suggest that they may represent a novel class of agents to treat immune-mediated diseases. PMID:18568076

  2. Multifunctional Materials Held in Boston, Massachusetts on November 29- December 1 1989. Materials Research Proceedings. Volume 175

    DTIC Science & Technology

    1991-02-01

    MULTIFUNCTIONAL MATERIALS *MULTIFUNCTIONAL MOLECULAR AND POLYMERIC MATERIALS FOR NONLINEAR OPTICS AND PHOTONICS 79 Paras N. Prasad ENHANCEMENT OF...in solution 121. Only the ortho photo-Fries product can be formed for the polymer as well as for 5 since the para positions in both cases are blocked...fhII11111 Itf 111111111ll1111111II 111 111 , 9 MULTIFUNCTIONAL MOLECULAR AND POLYMERIC MATERIALS FOR NONLINEAR OPTICS AND PHOTONICS PARAS N. PRASAD

  3. Thermal Response Turbine Shroud.

    DTIC Science & Technology

    1979-11-01

    AD-AO82 754. GENERAL ELECTRIC CO CINCINNATI OH AIRCRAFT ENGINE GROUP F/G 21/5 THERMAL RESPONSE TURBINE SHROUO.(UI NOV 79 C N GAY F33615-7B-C-2071...SUPPLEMENTARY NOTES IS. IEV WORDS (C..tIam. ON guinea 80410 Itf08M 8". 1~0 &VU~ b lma n-M-) Clearance Shroud Clearance Control Turbine Shroud engine / aircrafte ...compressor Active Clearance Control Systems (ACC) de-signed for aircraft gas turbine engine applications. The study vas conducted by personnel of the

  4. [Pedicle flaps based on the sphenopalatine artery: anatomical and surgical study].

    PubMed

    Gras-Cabrerizo, Juan R; Gras-Albert, Juan R; Monjas-Canovas, Irene; García-Garrigós, Elena; Montserrat-Gili, Joan R; Sánchez del Campo, Francisco; Kolanczak, Katarzyna; Massegur-Solench, Humbert

    2014-01-01

    Local pedicle flaps based on the sphenopalatine artery make it possible to reconstruct large defects of the skull base (SB). From January 2008 to January 2013, 64 lesions with involvement of SB were analysed. These lesions were treated using endoscopic endonasal approach and required a pedicle flap based on the sphenopalatine artery. In addition, measurements and flexibility of the flaps were examined in 4 cadaveric nasal cavities. Surgical group. Sixty-four nasoseptal flaps (NSF) were used, in 4 cases associated with a middle turbinate flap (MTF), and in 1 case supplemented with an inferior turbinate flap (ITF). Five cerebrospinal fluid fistulas (8%) were noted. Among patients with initial lesions, 7% presented an anosmia. Cadaveric group. The length of the NSF varied between 5.2 cm and 7.7 cm and the width ranged from 3 cm to 4.5 cm. The ITF provided an anterior-posterior distance between 4.2 cm and 5 cm, with a width between 1.2 cm and 2.8 cm. The mean length of MTFs varied between 3.5 cm and 4.2 cm, with a width between 1.4 cm and 1.9 cm. The most versatile local flap for the reconstruction of skull base defects is the NSF, and flaps pedicled to the posterolateral nasal artery offer an excellent alternative. Copyright © 2013 Elsevier España, S.L. y Sociedad Española de Otorrinolaringología y Patología Cérvico-Facial. All rights reserved.

  5. Implication of fermentable carbohydrates targeting the gut microbiota on conjugated linoleic acid production in high-fat-fed mice.

    PubMed

    Druart, Céline; Neyrinck, Audrey M; Dewulf, Evelyne M; De Backer, Fabienne C; Possemiers, Sam; Van de Wiele, Tom; Moens, Frédéric; De Vuyst, Luc; Cani, Patrice D; Larondelle, Yvan; Delzenne, Nathalie M

    2013-09-28

    In vitro experiments have shown that isolated human gut bacteria are able to metabolise PUFA into conjugated PUFA like conjugated linoleic acids (CLA). The hypothesis of the present paper was that high-fat (HF) diet feeding and supplementation with fermentable carbohydrates that have prebiotic properties modulate the in vivo production of CLA by the mouse gut microbiota. Mice were treated for 4 weeks as follows: control (CT) groups were fed a standard diet; HF groups were fed a HF diet rich in linoleic acid (18 : 2n-6); the third groups were fed with the HF diet supplemented with either inulin-type fructans (HF-ITF) or arabinoxylans (HF-Ax). HF diet feeding increased rumenic acid (cis-9,trans-11-18 : 2 CLA) content both in the caecal and liver tissues compared with the CT groups. ITF supplementation had no major effect compared with the HF diet whereas Ax supplementation increased further rumenic acid (cis-9,trans-11-18 : 2 CLA) in the caecal tissue. These differences between both prebiotics may be linked to the high fat-binding capacity of Ax that provides more substrates for bacterial metabolism and to differential modulation of the gut microbiota (specific increase in Roseburia spp. in HF-Ax v. HF). In conclusion, these experiments supply the proof of concept that the mouse gut microbiota produces CLA in vivo, with consequences on the level of CLA in the caecal and liver tissues. We postulate that the CLA-producing bacteria could be a mediator to consider in the metabolic effects of both HF diet feeding and prebiotic supplementation.

  6. Interhemispheric SST gradient trends in the Indian Ocean prior to and during the recent global warming hiatus

    NASA Astrophysics Data System (ADS)

    Dong, L.; McPhaden, M. J.

    2016-12-01

    Sea surface temperatures (SSTs) have been rising for decades in the Indian Ocean in response to greenhouse gas forcing. However, in this study we show that during the recent hiatus in global warming, a striking interhemispheric gradient in Indian Ocean SST trends developed around 2000, with relatively weak or little warming to the north of 10°S and accelerated warming to the south of 10oS. We present evidence from a wide variety of data sources that this interhemispheric gradient in SST trends is forced primarily by an increase of Indonesian Throughflow (ITF) transport from the Pacific into the Indian Ocean induced by stronger Pacific trade winds. This increased transport led to a depression of the thermocline that facilitated SST warming presumably through a reduction in the vertical turbulent transport of heat in the southern Indian Ocean. Surface wind changes in the Indian Ocean linked to the enhanced Walker circulation also may have contributed to thermocline depth variations and associated SST changes, with downwelling favorable wind stress curls between 10oS and 20oS and upwelling favorable wind stress curls between the equator and 10oS. In addition, the anomalous southwesterly wind stresses off the coast of Somalia favored intensified coastal upwelling and off-shore advection of upwelled water, which would have led to reduced warming of the northern Indian Ocean. Though highly uncertain, lateral heat advection associated with the ITF and surface heat fluxes may also have played a role in forming the interhemispheric SST gradient change.

  7. Relationships between southeastern Australian rainfall and sea surface temperatures examined using a climate model

    NASA Astrophysics Data System (ADS)

    Watterson, I. G.

    2010-05-01

    Rainfall in southeastern Australia has declined in recent years, particularly during austral autumn over the state of Victoria. A recent study suggests that sea surface temperature (SST) variations in both the Indonesian Throughflow (ITF) region and in a meridional dipole in the central Indian Ocean have influenced Victorian late autumn rainfall since 1950. However, it remains unclear to what extent SSTs in these and other regions force such a teleconnection. Analysis of a 1080 year simulation by the climate model CSIRO Mk3.5 shows that the model Victorian rainfall is correlated rather realistically with SSTs but that part of the above relationships is due to the model ENSO. Furthermore, the remote patterns of pressure, rainfall, and land temperature greatly diminish when the data are lagged by 1 month, suggesting that the true forcing by the persisting SSTs is weak. In a series of simulations of the atmospheric Mk3.5 with idealized SST anomalies, raised SSTs to the east of Indonesia lower the simulated Australian rainfall, while those to the west raise it. A positive ITF anomaly lowers pressure over Australia, but with little effect on Victorian rainfall. The meridional dipole and SSTs to the west and southeast of Australia have little direct effect on southeastern Australia in the model. The results suggest that tropical SSTs predominate as an influence on Victorian rainfall. However, the SST indices appear to explain only a fraction of the observed trend, which in the case of decadal means remains within the range of unforced variability simulated by Mk3.5.

  8. Water Distribution Analysis and Optimization (WADISO). User’s Guide and Documentation. Chapter 28, Parts 1 and 2, Change 6.

    DTIC Science & Technology

    1987-07-01

    the initial tank water level in feet. If any fires were specified, TIMEOT prints the node number supplying the fire flow, NFIRE ; the starting time step...0 0 LPT Array 1 22 10 11 0.100000000E+04 NF, NFIRE , ITF, IDF. FF 3 25 0.130000000E+03 0.800000000E+02 0.20000000000E+04 0.1100000000E+03 NTN; UPL...of input error. ERROR NF RETIME Number of fires in system. STOTIM NFIRE (5) /TIME/ User node supplying fire flow. NFIRE (1)=6 indicates user node 6 is

  9. Advanced Metallic Air Vehicle Structure Program

    DTIC Science & Technology

    1976-08-01

    r-Ř Z- cq rXH H ý-q P7 PI-I .rý17 > r4 %. I~tf Ifr )~ 1 m L cc -I O’t %D-Z r- 0~ c-4) 0ff f ~ ~ L ~ L~f a’oY C ca \\D oIt 01\\ mc I’DJ c-o ’-4<tD -zt...FIGURE~COV 2..111 HET O FASTNERHOLEIDETIFIATIN - PPE UCOER 87;B 7- 276 C-1 UPPER 5URFACE Tyl so L2 2.O-t- y ESP AT APPLED O AVSUR \\L1 Lt OF02O~ X72

  10. A Structural Weight Estimation Program (SWEEP) for Aircraft. Volume III - Airloads Estimation Module. Appendix A: Module Flow Charts and FORTRAN Lists. Appendix B: Sample Output

    DTIC Science & Technology

    1974-06-01

    COMMERCE . ■ . ..,...-: . c.. . . . .... .. . . . -. . Best Available Copy .. . . ’ . . . . ■ . «ICUWITV CCMHyiCATlOM 0’ TMII PAOC tW* m ...aircraft structural weight optimization, flutter optimization program, structural synthesis 10 ABSTRACT rCwidnu« on r«v»ft« «itf* M i Three...PAaZfVhtt Data tnffd) «cs;-W!.’i \\K »ifl • Jrflu 5/ r * i» .... ,r, M I J » i| *k\\Ui »’ PUT« « UM irr;!■ ,•’ rfra A NOTICES When

  11. Electromagnetic-field dependence of the internal excited state of the polaron and the qubit in quantum dot with thickness

    NASA Astrophysics Data System (ADS)

    Bai, Xu-Fang; Xin, Wei; Yin, Hong-Wu; Eerdunchaolu

    2017-06-01

    The electromagnetic-field dependence of the ground and the first excited-state (GFES) energy eigenvalues and eigenfunctions of the strong-coupling polaron in a quantum dot (QD) was studied for various QD thicknesses by using the variational method of the Pekar type (VMPT). On this basis, we construct a qubit in the quantum dot (QQD) by taking a two-level structure of the polaron as the carrier. The results of numerical calculations indicate that the oscillation period of the qubit, {itT}{in0}, increases with increasing the thickness of the quantum dot (TQD) {itL}, but decreases with increasing the cyclotron frequency of the magnetic field (CFMF) ω{in{itc}}, electric-field strength {itF}, and electron-phonon coupling strength (EPCS) α. The probability density of the qubit |Ψ({itρ}, {itz}, {itt})|{su2} presents a normal distribution of the electronic transverse coordinate ρ, significantly influenced by the TQD and effective radius of the quantum dot (ERQD) {itR}{in0}, and shows a periodic oscillation with variations in the electronic longitudinal coordinate {itz}, polar angle φ and time {itt}. The decoherence time τ and the quality factor {itQ} of the free rotation increase with increasing the CFMF ω{in{itc}}, dispersion coefficient η, and EPCS α, but decrease with increasing the electric-field strength {itF}, TQD {itL}, and ERQD {itR}{in0}. The TQD is an important parameter of the qubit. Theoretically, the target, which is to regulate the oscillation period, decoherence time and quality factor of the free rotation of the qubit, can be achieved by designing different TQDs and regulating the strength of the electromagnetic field.

  12. Meridional overturning and large-scale circulation of the Indian Ocean

    NASA Astrophysics Data System (ADS)

    Ganachaud, Alexandre; Wunsch, Carl; Marotzke, Jochem; Toole, John

    2000-11-01

    The large scale Indian Ocean circulation is estimated from a global hydrographic inverse geostrophic box model with a focus on the meridional overturning circulation (MOC). The global model is based on selected recent World Ocean Circulation Experiment (WOCE) sections which in the Indian Basin consist of zonal sections at 32°S, 20°S and 8°S, and a section between Bali and Australia from the Java-Australia Dynamic Experiment (JADE). The circulation is required to conserve mass, salinity, heat, silica and "PO" (170PO4+O2). Near-conservation is imposed within layers bounded by neutral surfaces, while permitting advective and diffusive exchanges between the layers. Conceptually, the derived circulation is an estimate of the average circulation for the period 1987-1995. A deep inflow into the Indian Basin of 11±4 Sv is found, which is in the lower range of previous estimates, but consistent with conservation requirements and the global data set. The Indonesian Throughflow (ITF) is estimated at 15±5 Sv. The flow in the Mozambique Channel is of the same magnitude, implying a weak net flow between Madagascar and Australia. A net evaporation of -0.6±0.4 Sv is found between 32°S and 8°S, consistent with independent estimates. No net heat gain is found over the Indian Basin (0.1 ± 0.2PW north of 32°S) as a consequence of the large warm water influx from the ITF. Through the use of anomaly equations, the average dianeutral upwelling and diffusion between the sections are required and resolved, with values in the range 1-3×10-5 cm s-1 for the upwelling and 2-10 cm2 s-1 for the diffusivity.

  13. Paleoproductivity and Nutrient Cycling on the Sumatra Margin during the Past Half Million Years

    NASA Astrophysics Data System (ADS)

    Gibson, K.; Mitt Schwamborn, T.; Thunell, R.; Tuten, E. C.; Swink, C.; Tappa, E.

    2017-12-01

    In the IndoPacific, changes in paleoproductivity on orbital timescales are often linked to changes in precession, particularly in areas of coastal upwelling. These changes are in turn related to variations in zonal wind patterns and thermocline tilt associated with the El Niño Southern Oscillation (ENSO) and the Indian Ocean Dipole (IOD), and commensurate changes in Asian, Indian, and Australian monsoon precipitation and wind-driven upwelling. Previous studies have revealed varying phase relationships amongst monsoon precipitation, upwelling variability and precession minima in the Indo-Pacific region. Regional records have additionally displayed power in the 41-kyr band, attributed to changes in deepwater ventilation and preservation, and the 100-kyr band, related to the influence of sea level on the Indonesian Throughflow (ITF). To provide further insight into the regional and distal forcing on paleoproductivity and nutrient cycling in this clearly complex region, we present %TOC, %CaCO3, and sedimentary δ15N data from core MD98-2152, off the Sumatra margin in a region influenced by both ITF variability and wind-driven upwelling. By comparing our paleoproductivity and paleonutrient data with planktonic δ18O (tuned to composite Chinese cave speleothem records) and benthic δ18O (tuned to the Lisiecki-Raymo Stack), we compare timing of local productivity changes to high latitude ice-volume changes and local hydrographic changes. A strong 23-kyr signal in the %TOC record supports the strong influence of precession on paleoproductivity in this region. In contrast, strong power in the 100 and 41-kyr bands is observed in %CaCO3 and δ15N with a relatively minor contribution from precession, indicating a complex relationship between nutrient cycling, upwelling, production, and preservation on the Sumatra coast.

  14. Modeling the Climatic Effect of Convergent Tectonics During the Middle to Late Miocene: Effective Closure of the Indonesian Seaway, Himalayan Uplift and the East Asian Monsoon

    NASA Astrophysics Data System (ADS)

    DeConto, R. M.; MacConnell, A.; Leckie, R.

    2001-05-01

    During the middle to late Miocene, the northward drift of Australia and New Guinea progressively restricted Indonesian throughflow (ITF). Today, ITF plays an important role in modulating inter-basin fresh water flux, heat transport, and the volume of the Western Pacific Warm Pool (WPWP). Today's WPWP is a center for deep convection that contributes considerable diabatic heating to the tropical atmosphere, affecting both the Walker and Hadley circulation. The WPWP fuels the East Asian Monsoon with moisture and latent heat and is an important component of ENSO. As the Indonesian Seaway became restricted, India was impinging on Asia. Asian continentality was increased and Himalayan/Tibetan uplift begun affecting zonal atmospheric flow and land-surface albedo. In order to better understand the climate system's response to changing Miocene paleogeography (horizontal and vertical tectonics), we have begun a series of climate model experiments using atmosphere, ocean, and coupled atmosphere-ocean general circulation models (GCMs). The GCM experiments are designed to isolate the possible response to effective Indonesian gateway closure within the framework of evolving Miocene Paleogeography between 11 and 7 Ma. In the first phase of our modeling study, an AGCM was used to test the sensitivity of tropical Indo-Pacific and Asian climate (including monsoonal intensity) to the presence of a WPWP in a pre and post Himalayan/Tibetan Plateau world. The results of the GCM simulations will be discussed in the context of the hypotheses that 1) a proto-WPWP became established as the Indonesian Seaway became increasingly restricted during the late middle to late Miocene; and 2) the growth of the WPWP had a first order affect on tropical Pacific climate and the East Asian monsoon.

  15. The prognostic value of tip-to-apex distance (TAD index) in intertrochanteric fractures fixed by dynamic hip screw.

    PubMed

    Sedighi, Ali; Sales, Jafar Ganjpour; Alavi, Sahar

    2012-11-02

    Intertrochanteric fractures (ITFs) are the most common type of fractures requiring surgical intervention. They also have the highest surgical mortality among orthopedic operations. Among the many different techniques used for fixation of this type of fracture, use of the Dynamic Hip Screw (DHS) has gained wide acceptance. This current study was designed to assess positive predictive value of tip-to-apex distance (TAD) index in the prognosis of patients treated with DHS. The study was designed according to a descriptive-analytic protocol, made up of 100 cases of ITFs caused by falling, treated in the Shohada Orthopedic Center, Tabriz, Iran. All patients underwent lateral and antero-posterior hip X-ray to measure TAD index. The cohort was followed for three months after DHS placement. Of a total of 100 cases (53 male, 47 female) with a mean age of 76.7 years (range 29-100 years), 43% had grade 4, 29% grade 3, 21% grade 5, 5% grade 2 and 2% grade 6 osteoporosis. The screw position was postero-inferior in 57%, central in 40% and superior in 3% of patients. Minimum and maximum TAD index were 20 and 28 mm, respectively. Mean TAD was 23.5 mm. There were no post-operative complications in 84% of cases. Screw failure was the most common complication in the remaining 16% of patients. The study shows a statistically significant correlation between TAD index and cut-off rate in patients with intertrochanteric fractures of femoral bone treated by DHS. This validates the use of TAD index in determining the prognosis of patients treated by DHS.

  16. Visualization of the Flow at the Tip of a High Speed Axial Flow Turbine Rotor Blade - An Assessment of Flow Visualisation Techniques and the Requirement of the Experimental Turbine.

    DTIC Science & Technology

    1987-11-01

    71 AD-AI89 929 UI4A ~l HOFTEFOJA N TIPO IO PE /L S LO TUIN~. TCHN ?IRAEL’ITF 4XHH F IDNE AL. T U 87 AFOs -8-U N uNCLASSIFIED NIF-: Hrp li1.0 a18...Pulse tracer injection 16. 9) Detector sensor 17- 10) Focussed photomultiplier 17 Conceptual philosophy for the experimental turbine 18 Preliminary...tracing 35 2) Pulsed fluorescence 35 3) Single spot laser sensor 36 4) Two spot laser 36 5) Localised smoke pockets 37 6) Laser pulse smoke generation

  17. Nutritional status and dental fluorosis among schoolchildren in communities with different drinking water fluoride concentrations in a central region in Mexico.

    PubMed

    Irigoyen-Camacho, M E; García Pérez, A; Mejía González, A; Huizar Alvarez, R

    2016-01-15

    Poor water quality and under nutrition are important factors affecting the health of many communities in developing countries. The aims of this study were: i) to describe the fluoride water concentration and the hydrogeological conditions in a region of a state located in the central in Mexico ii) to measure the association between undernutrition and dental fluorosis in children living in communities with different drinking water fluoride concentrations in a state located in the central region of Mexico. Field work was performed in the region to identify the prevailing groundwater flow characteristics and water wells were sampled to analyze water fluoride concentration. Children were selected from three communities that had different drinking water fluoride concentrations (i.e., 0.56, 0.70 and 1.60 mg/l). Fluoridated salt was available in these communities. The Thylstrup-Fejerskov Index (TFI) was used to assess dental fluorosis. Categories four or higher of this index involve changes in the entire tooth surface (ITF ≥ 4). The weight and height of the children were measured. The assessment of undernutrition was based on the World Health Organization criteria: children were classified as being at risk of low-height (Height-for-Age Z score < − 1.0 SD) and having low-height (Height-for-Age Z score < − 2.0 SD) for age and sex, the same cutoff points of the Z score were used to classify "risk of low-weight" and" low-weight children". In the region the mineralization of the water captured by the wells is the result of a reaction with volcanic materials. The water fluoride concentration in the region ranged from 0.2 to 1.6 mg/l. A total of 734 schoolchildren participated in the study. The percentage of children in fluorosis categories (ITF ≥ 4) was 15.9%, 21.1% of the children were at risk of low height-for-age, and 8.0% had low height-for-age. The percentage of children with fluorosis (ITF ≥ 4) was 6.3%, 9.1% and 31.9% (p ˂ 0.001) and low high-for-age was 2.9%, 2.5% and 8.4% (p ˂ 0.001), for the communities with F concentrations of 0.56 mg/l, 0.70 mg/l and 1.6 mg/l, respectively. The logistic regression model showed an association between dental fluorosis (TFI ≥ 4) and low height-for-age (OR 2.09, p = 0.022) after adjusting for sex, number of teeth erupted, source of drinking water, use of fluoridated toothpaste and tap water fluoride concentration in the community. Children with low height-for-age were more likely to have dental fluorosis in the TFI categories that affect the entire tooth surface. The results suggest that subpopulations with chronic undernutrition are more susceptible to dental fluorosis.

  18. Seasonal variation of the South Indian tropical gyre

    NASA Astrophysics Data System (ADS)

    Aguiar-González, Borja; Ponsoni, Leandro; Ridderinkhof, Herman; van Aken, Hendrik M.; de Ruijter, Will P. M.; Maas, Leo R. M.

    2016-04-01

    The South Indian tropical gyre receives and redistributes water masses from the Indonesian Throughflow (ITF), a source of Pacific Ocean water which represents the only low-latitude connector between the world oceans and, therefore, a key component in the global ocean circulation and climate system. We investigate the seasonal variation of the South Indian tropical gyre and its associated open-ocean upwelling system, known as the Seychelles-Chagos Thermocline Ridge (SCTR), based on satellite altimeter data (AVISO) and global atlases of temperature and salinity (CARS09), wind stress (SCOW) and wind-driven circulation. Two novel large-scale features governing the upper geostrophic circulation of the South Indian tropical gyre are revealed. First, the seasonal shrinkage of the ocean gyre. This occurs when the South Equatorial Countercurrent (SECC) recirculates before arrival to Sumatra from winter to spring, in apparent synchronization with the annual cycle of the ITF. Second, the open-ocean upwelling is found to vary following seasonality of the overlying geostrophic ocean gyre, a relationship that has not been previously shown for this region. An analysis of major forcing mechanisms suggests that the thermocline ridge results from the constructive interaction of basin-scale wind stress curl, local-scale wind stress forcing and remote forcing driven by Rossby waves of different periodicity: semiannual in the west, under the strong influence of monsoonal winds; and, annual in the east, where the southeasterlies prevail. One exception occurs during winter, when the well-known westward intensification of the upwelling core, the Seychelles Dome, is shown to be largely a response of the wind-driven circulation. Broadly speaking, the seasonal shrinkage of the ocean gyre (and the SCTR) is the one feature that differs most when the geostrophic circulation is compared to the wind-driven Sverdrup circulation. From late autumn to spring, the eastward SECC recirculates early in the east on feeding the westward South Equatorial Current, therefore closing the gyre before arrival to Sumatra. We find this recirculation longitude migrates over 20° and collocates with the westward advance of a zonal thermohaline front emerging from the encounter between (upwelled) Indian Equatorial Water and relatively warmer and fresher Indonesian Throughflow Water. We suggest this front, which we call the Indonesian Throughflow Front, plays an important role as forcing to the tropical gyre, generating southward geostrophic flows that contribute to the early recirculation of the SECC at longitudes more westward than predicted from the barotropic wind-driven circulation. Because our findings are based on time-averaged seasonal fields from 22 years of satellite altimeter data and from about 60 years of non-systematic sampling of ocean temperature and salinity data (CARS09), we stress the importance of further study on the possibility that interanual variability in the seasonal ITF may cause changes in the seasonal resizing of the ocean gyre and its associated upwelling ridge.

  19. Iron mineralogy of the surface of Mars from the 1 μm band spectral properties

    NASA Astrophysics Data System (ADS)

    Carrozzo, F. G.; Altieri, F.; Bellucci, G.; Poulet, F.; D'Aversa, E.; Bibring, J.-P.

    2012-10-01

    We study the 1 μm absorption from OMEGA/MEX spectra to map Martian iron mineralogy at a global scale. This band is covered on the left by the VNIR (visible and near infrared) OMEGA channel and on the right by the SWIR (short wavelengths infrared) one. We first perform a systematic spatial coregistration of the two channels after an improvement of the VNIR radiometric calibration. The update of the VNIR Instrumental Transfer Function (ITF) and the internal stray-light estimation is based on the spectra of the Phobos red units and of the water ice north polar cap of Mars, which have been fitted according to an iterative process. The level of the signal in the blue wavelength range, previously systematically overestimated due to a stray-light residual and the general shape of the spectrum for λ > 0.7 μm are improved . Global maps of the 1 μm signature have been derived from 9 new spectral indices. The largest values of the 1 μm band integral are found in Noachian terrains and in the dunes around the north polar cap. In the south polar region, an area centered at ˜155°W and ˜83°S is mapped as a distinctive spectral unit, dominated by pyroxene. The northern lowlands of Mars together with other dark terrains located in the northern hemisphere show very low values of some spectral indices due to the negative spectral slope in the NIR. This behavior is consistent with the presence of weathered basalts with a possible glassy or amorphous component. Among the hydrated terrains, the only ones that can be isolated by studying the 1 μm band are those located in Terra Meridiani, Aram Chaos and Capri Chasma, enriched in sulfate and hematite. On the other hand, the sulfates of the dark dunes surrounding the northern polar cap and the phyllosilicates of the bright hydrated deposits of Mawrth Vallis cannot be isolated combining the parameters used in this study. This suggests that their distinctive mineralogy does not affect the 1 μm band, remaining similar to the global Martian average shape.

  20. A Structural Weight Estimation Program (SWEEP) for Aircraft. Volume 6 - Wing and Empennage Module. Appendix F: Program Listings, Overlays (9,0), (10, 0) and (18,0)

    DTIC Science & Technology

    1974-06-01

    icritii>cri%M crwi • ciiii/<crifi’cri«ii crtj» - c/<st/icri6)-cf isn ccm ■ criii -cri?i»cr(ii ccii’ • crtiiKn%t - criii *cri9t - cruitfiT» CCr.i...Hill • Ui^l »••» c »»K C TKim SP»«’ »9tC UI9I - IC’WfSSP’fcfitrill »9e7 win • ui9i*tr*s^ criii »»M T ItfCOCC - II III.III.IT« »»n n

  1. The Deep Meridional Overturning Circulation in the Indian Ocean Inferred from the GECCO Synthesis

    NASA Astrophysics Data System (ADS)

    Wang, W.; Koehl, A.; Stammer, D.

    2012-04-01

    The meridional overturning circulation in the Indian Ocean and its temporal variability in the GECCO ocean synthesis are being investigated. An analysis of the integrated circulation in different layers suggests that, on time average, 2.1 Sv enter the Indian Ocean in the bottom layer (>3200m) from the south and that 12.3 Sv leave the Indian Ocean in the upper and intermediate layers (<1500m), composed of the up-welled bottom layer inflow water, augmented by 9.6 Sv Indonesian Throughflow (ITF) water. The GECCO time-mean results differ significantly from those obtained by box inverse models, which, being based on individual hydrographic sections, are susceptible to aliasing. The GECCO solution has a large seasonal variation in its meridional overturning caused by the seasonal reversal of monsoon-related wind stress forcing. Associated seasonal variations of the deep meridional overturning range from -7 Sv in boreal winter to 3 Sv in summer. In addition, the upper and bottom transports across 34°S section show pronounced interannual variability with roughly biennial variations superimposed by strong anomalies during each La Niña phase as well as the ITF, which mainly affect the upper layer transports. On decadal and longer timescale, the meridional overturning variability as well as long-term trends differ before and after 1980. Notably, our analysis shows a rather stable trend for the period 1960-1979 and significant changes in the upper and bottom layer for the period 1980-2001. By means of a multivariate EOF analysis, the importance of Ekman dynamics as driving forces of the deep meridional overturning of the Indian Ocean on the interannual timescale is highlighted. The leading modes of the zonal and meridional wind stress favour a basin-wide meridional overturning mode via Ekman upwelling or downwelling mostly in the central and eastern Indian Ocean. Moreover, tropical zonal wind stress along the equator and alongshore wind stress off the Sumatra-Java coast contributes to evolution of IOD events.

  2. Binaural noise reduction via cue-preserving MMSE filter and adaptive-blocking-based noise PSD estimation

    NASA Astrophysics Data System (ADS)

    Azarpour, Masoumeh; Enzner, Gerald

    2017-12-01

    Binaural noise reduction, with applications for instance in hearing aids, has been a very significant challenge. This task relates to the optimal utilization of the available microphone signals for the estimation of the ambient noise characteristics and for the optimal filtering algorithm to separate the desired speech from the noise. The additional requirements of low computational complexity and low latency further complicate the design. A particular challenge results from the desired reconstruction of binaural speech input with spatial cue preservation. The latter essentially diminishes the utility of multiple-input/single-output filter-and-sum techniques such as beamforming. In this paper, we propose a comprehensive and effective signal processing configuration with which most of the aforementioned criteria can be met suitably. This relates especially to the requirement of efficient online adaptive processing for noise estimation and optimal filtering while preserving the binaural cues. Regarding noise estimation, we consider three different architectures: interaural (ITF), cross-relation (CR), and principal-component (PCA) target blocking. An objective comparison with two other noise PSD estimation algorithms demonstrates the superiority of the blocking-based noise estimators, especially the CR-based and ITF-based blocking architectures. Moreover, we present a new noise reduction filter based on minimum mean-square error (MMSE), which belongs to the class of common gain filters, hence being rigorous in terms of spatial cue preservation but also efficient and competitive for the acoustic noise reduction task. A formal real-time subjective listening test procedure is also developed in this paper. The proposed listening test enables a real-time assessment of the proposed computationally efficient noise reduction algorithms in a realistic acoustic environment, e.g., considering time-varying room impulse responses and the Lombard effect. The listening test outcome reveals that the signals processed by the blocking-based algorithms are significantly preferred over the noisy signal in terms of instantaneous noise attenuation. Furthermore, the listening test data analysis confirms the conclusions drawn based on the objective evaluation.

  3. An exploratory study into the putative prebiotic activity of fructans isolated from Agave angustifolia and the associated anticancer activity.

    PubMed

    Allsopp, Philip; Possemiers, Sam; Campbell, David; Oyarzábal, Iván Saldaña; Gill, Chris; Rowland, Ian

    2013-08-01

    Linear inulin-type fructan (ITF) prebiotics have a putative role in the prevention of colorectal cancer, whereas relatively little is known about branched fructans. This study aims to investigate the fermentation properties and potential prebiotic activity of branched fructans derived from Agave angustifolia Haw, using the Simulator of Human Intestinal Microbial Ecosystem (SHIME) model. The proximal, transverse and distal vessels were used to investigate fructan fermentation throughout the colon and to assess the alterations of the microbial composition and fermentation metabolites (short chain fatty acids and ammonia). The influence on bioactivity of the fermentation supernatant was assessed by MTT, Comet and transepithelial electrical resistance (TER), respectively. Addition of Agave fructan to the SHIME model significantly increased (P < 0.05), bifidobacteria populations (proximal and transverse), SCFA concentrations (proximal, transverse and distal) and decreased ammonia concentrations in the distal vessel. Furthermore, the fermentation supernatant significantly (P < 0.05) increased the TER of a Caco-2 cell monolayer (%) and decreased fluorescein-based paracellular flux, suggesting enhanced barrier function and reduced epithelial barrier permeability (proximal and distal vessel). While cytotoxicity and genotoxicity remained unaltered in response to the presence of Agave fructans. To conclude, branched Agave fructans show indications of prebiotic activity, particularly in relation to colon health by exerting a positive influence on gut barrier function, an important aspect of colon carcinogenesis. Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.

  4. PAL-XFEL cavity beam position monitor pick-up design and beam test

    NASA Astrophysics Data System (ADS)

    Lee, Sojeong; Park, Young Jung; Kim, Changbum; Kim, Seung Hwan; Shin, Dong Cheol; Han, Jang-Hui; Ko, In Soo

    2016-08-01

    As an X-ray Free Electron Laser, PAL-XFEL is about to start beam commissioning. X-band cavity beam position monitor (BPM) is used in the PAL-XFEL undulator beam line. Prototypes of cavity BPM pick-up were designed and fabricated to test the RF characteristics. Also, the beam test of a cavity BPM pick-up was done in the Injector Test Facility (ITF). In the beam test, the raw signal properties of the cavity BPM pick-up were measured at a 200 pC bunch charge. According to the RF test and beam test results, the prototype cavity BPM pick-up design was confirmed to meet the requirements of the PAL-XFEL cavity BPM system.

  5. Design of High Field Solenoids made of High Temperature Superconductors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bartalesi, Antonio; /Pisa U.

    2010-12-01

    This thesis starts from the analytical mechanical analysis of a superconducting solenoid, loaded by self generated Lorentz forces. Also, a finite element model is proposed and verified with the analytical results. To study the anisotropic behavior of a coil made by layers of superconductor and insulation, a finite element meso-mechanic model is proposed and designed. The resulting material properties are then used in the main solenoid analysis. In parallel, design work is performed as well: an existing Insert Test Facility (ITF) is adapted and structurally verified to support a coil made of YBa{sub 2}Cu{sub 3}O{sub 7}, a High Temperature Superconductormore » (HTS). Finally, a technological winding process was proposed and the required tooling is designed.« less

  6. Mining the Internet for Intro Physics Data: Sports Equipment

    NASA Astrophysics Data System (ADS)

    Pawl, Andrew; Pritchard, David; Barrantes, Analia

    2008-10-01

    Problems using typical numbers for sports equipment parameters such as: ``A 0.285 kg tennis racket strikes a 0.058 kg tennis ball'' are common in introductory physics. The numbers are usually reasonable, but often do not tell the whole story. Continuing with the example above, tennis ball masses are tightly constrained by the International Tennis Federation (ITF) to range between 56.0 g and 59.4 g, but the rules do not restrict the mass of tennis rackets. Instead, physics plays an important role in fixing the preferred tennis racket mass. In this presentation, we give an example of how internet research using the readily available commercial websites of sports equipment manufacturers can enrich introductory physics problems and spark interesting follow-up questions.

  7. Impact Testing for Materials Science at NASA - MSFC

    NASA Technical Reports Server (NTRS)

    Sikapizye, Mitch

    2010-01-01

    The Impact Testing Facility (ITF) at NASA - Marshall Space Flight Center is host to different types of guns used to study the effects of high velocity impacts. The testing facility has been and continues to be utilized for all NASA missions where impact testing is essential. The Facility has also performed tests for the Department of Defense, other corporations, as well as universities across the nation. Current capabilities provided by Marshall include ballistic guns, light gas guns, exploding wire gun, and the Hydrometeor Impact Gun. A new plasma gun has also been developed which would be able to propel particles at velocities of 20km/s. This report includes some of the guns used for impact testing at NASA Marshall and their capabilities.

  8. Cooperative Security in Northeast Asia. A China-Japan-South Korea Coalition Approach

    DTIC Science & Technology

    1990-01-01

    14)1) cSidllishl~ilg a sinIIdI4.i lis15 o I S treg (ional sccuh ii Of , orts. Of) licccss’i1 . scYcrdI I I(l IWtV \\ "ItIg"t CalV(Iiigi CM-t iaua tics...hoiliogtimi A -11 1)jiit(11]-(.( ( dl 0III 1Kmi (2 vI rl cnrl(111 ii(12 Oii~ f th an IiU 11(h2ld tid(2. I ilc - historic111es kt~Ii .ts he~ MSiiiitC...See- ietiarvN oF[ State \\( Ilcs (tIl (Iili 1101 Hiclittio the Korean P~eninisula inl (ItfIiniti ’s g’lobal sceur i initere’sts, ledl to the Soviet- land

  9. All Prime Contract Awards by State or Country, Place, and Contractor. Part 23 (Iceland-TRW INC Classified Location)

    DTIC Science & Technology

    1990-01-01

    0 U anoonno Q0000mnh00 C21 000 cc 00m0h00h9 103M CIO U U -4N0I H * o~ O444444N~C200 0 00 cc -4 CocoU -4000 * iaU-iNMU<: WW -4-4-4-4-4-i C404Nqf 4 -4...0 8 rH Ia. 4 0 P4 PI. 00& soG or r ,4 - . .#.- ,I.t-f .4 W-404 0 0 4 4. 4 co4 0 40a 0000000 -1- 9( 0 3co000 * In 6 344 0 40 0 a0 c 0 00>>>WA>>>>> * 0

  10. Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC).

    PubMed

    Zheng, Jie; van de Veerdonk, Frank L; Crossland, Katherine L; Smeekens, Sanne P; Chan, Chun M; Al Shehri, Tariq; Abinun, Mario; Gennery, Andrew R; Mann, Jelena; Lendrem, Dennis W; Netea, Mihai G; Rowan, Andrew D; Lilic, Desa

    2015-10-01

    Signal transducer and activator of transcription 3 (STAT3) triggered production of Th-17 cytokines mediates protective immunity against fungi. Mutations affecting the STAT3/interleukin 17 (IL-17) pathway cause selective susceptibility to fungal (Candida) infections, a hallmark of chronic mucocutaneous candidiasis (CMC). In patients with autosomal dominant CMC, we and others previously reported defective Th17 responses and underlying gain-of-function (GOF) STAT1 mutations, but how this affects STAT3 function leading to decreased IL-17 is unclear. We also assessed how GOF-STAT1 mutations affect STAT3 activation, DNA binding, gene expression, cytokine production, and epigenetic modifications. We excluded impaired STAT3 phosphorylation, nuclear translocation, and sequestration of STAT3 into STAT1/STAT3 heterodimers and confirm significantly reduced transcription of STAT3-inducible genes (RORC/IL-17/IL-22/IL-10/c-Fos/SOCS3/c-Myc) as likely underlying mechanism. STAT binding to the high affinity sis-inducible element was intact but binding to an endogenous STAT3 DNA target was impaired. Reduced STAT3-dependent gene transcription was reversed by inhibiting STAT1 activation with fludarabine or enhancing histone, but not STAT1 or STAT3 acetylation with histone deacetylase (HDAC) inhibitors trichostatin A or ITF2357. Silencing HDAC1, HDAC2, and HDAC3 indicated a role for HDAC1 and 2. Reduced STAT3-dependent gene transcription underlies low Th-17 responses in GOF-STAT1 CMC, which can be reversed by inhibiting acetylation, offering novel targets for future therapies. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Relationships between the decoupled and coupled transfer functions: Theoretical studies and experimental validation

    NASA Astrophysics Data System (ADS)

    Wang, Zengwei; Zhu, Ping; Liu, Zhao

    2018-01-01

    A generalized method for predicting the decoupled transfer functions based on in-situ transfer functions is proposed. The method allows predicting the decoupled transfer functions using coupled transfer functions, without disassembling the system. Two ways to derive relationships between the decoupled and coupled transfer functions are presented. Issues related to immeasurability of coupled transfer functions are also discussed. The proposed method is validated by numerical and experimental case studies.

  12. The Data Base for the May 1979 Marine Surface Layer Micrometeorological Experiment at San Nicolas Island, California.

    DTIC Science & Technology

    1982-05-07

    ATIO VE LOC I TY HUMIDITY TEMP. L ENGTH ClIFF. 72% 7TO 160 4% 53% IS 5% A8t RZ lit 492 29% 23% END Of DATA RIiM 29 MARINE SURFACE LAYER...DRAG NO.AT GMM AlTOIM FL UX FLUX FLUX FL UX FLU X RTATIO VK LOC ITTY HUtMIDITY TEMP. LEN4GTH COE. 160% 161% 116% 167% 128% 9% 124% 295% s8% 109% 71...SCC PSI 90951!4 DRAG; NT, VT "MXT ’tI TIM ELS L X H Sy I 1(09rU F LT PtX ATIO VE LOC ITY ((IIDITIY TE MP. L EM!.TIH ItF 11% (1, .14% Il 195 Tx 5% 2A

  13. The deep meridional overturning circulation in the Indian Ocean inferred from the GECCO synthesis

    NASA Astrophysics Data System (ADS)

    Wang, Weiqiang; Köhl, Armin; Stammer, Detlef

    2012-11-01

    The deep time-varying meridional overturning circulation (MOC) in the Indian Ocean in the German “Estimating the Circulation and Climate of the Ocean” consortium efforts (GECCO) ocean synthesis is being investigated. An analysis of the integrated circulation suggests that, on time average, 2.1 Sv enter the Indian Ocean in the bottom layer (>3200 m) from the south and that 12.3 Sv leave the Indian Ocean in the upper and intermediate layers (<1500 m), composed of the up-welled bottom layer inflow water, augmented by 9.6 Sv Indonesian Throughflow (ITF) water. The GECCO time-mean results differ substantially from those obtained by inverse box models, which being based on individual hydrographic sections and due to the strong seasonal cycle are susceptible to aliasing. The GECCO solution shows a large seasonal variation in its deep MOC caused by the seasonal reversal of monsoon-related wind stress forcing. The associated seasonal variations of the deep MOC range from -7 Sv in boreal winter to 3 Sv in summer. In addition, the upper and bottom transports across the 34°S section show pronounced interannual variability with roughly biennial variations superimposed by strong anomalies during each La Niña phase as well as the ITF, which mainly affect the upper layer transports. On decadal and longer timescale, the meridional overturning variability as well as long-term trends differs before and after 1980. GECCO shows a stable trend for the period 1960-1979 and substantial changes in the upper and bottom layer for the period 1980-2001. By means of an extended EOF analysis, the importance of Ekman dynamics as driving forces of the deep MOC of the Indian Ocean on the interannual timescale is highlighted. The leading modes of the zonal and meridional wind stress favour a basin-wide meridional overturning mode via Ekman upwelling or downwelling mostly in the central and eastern Indian Ocean. Moreover, tropical zonal wind stress along the equator and alongshore wind stress off the Sumatra-Java coast contribute to the evolution of the Indian Ocean dipole (IOD) events.

  14. Evaluation of an operational ocean model configuration at 1/12° spatial resolution for the Indonesian seas (NEMO2.3/INDO12) - Part 1: Ocean physics

    NASA Astrophysics Data System (ADS)

    Tranchant, Benoît; Reffray, Guillaume; Greiner, Eric; Nugroho, Dwiyoga; Koch-Larrouy, Ariane; Gaspar, Philippe

    2016-03-01

    INDO12 is a 1/12° regional version of the NEMO physical ocean model covering the whole Indonesian EEZ (Exclusive Economic Zone). It has been developed and is now running every week in the framework of the INDESO (Infrastructure Development of Space Oceanography) project implemented by the Indonesian Ministry of Marine Affairs and Fisheries. The initial hydrographic conditions as well as open-boundary conditions are derived from the operational global ocean forecasting system at 1/4° operated by Mercator Océan. Atmospheric forcing fields (3-hourly ECMWF (European Centre for Medium-Range Weather Forecast) analyses) are used to force the regional model. INDO12 is also forced by tidal currents and elevations, and by the inverse barometer effect. The turbulent mixing induced by internal tides is taken into account through a specific parameterisation. In this study we evaluate the model skill through comparisons with various data sets including outputs of the parent model, climatologies, in situ temperature and salinity measurements, and satellite data. The biogeochemical model results assessment is presented in a companion paper (Gutknecht et al., 2015). The simulated and altimeter-derived Eddy Kinetic Energy fields display similar patterns and confirm that tides are a dominant forcing in the area. The volume transport of the Indonesian throughflow (ITF) is in good agreement with the INSTANT estimates while the transport through Luzon Strait is, on average, westward but probably too weak. Compared to satellite data, surface salinity and temperature fields display marked biases in the South China Sea. Significant water mass transformation occurs along the main routes of the ITF and compares well with observations. Vertical mixing is able to modify the South and North Pacific subtropical water-salinity maximum as seen in T-S diagrams. In spite of a few weaknesses, INDO12 proves to be able to provide a very realistic simulation of the ocean circulation and water mass transformation through the Indonesian Archipelago. Work is ongoing to reduce or eliminate the remaining problems in the second INDO12 version.

  15. 5 CFR 351.303 - Identification of positions with a transferring function.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... transferring function. 351.303 Section 351.303 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS REDUCTION IN FORCE Transfer of Function § 351.303 Identification of positions with a transferring function. (a) The competitive area losing the function is responsible for identifying the...

  16. 5 CFR 351.303 - Identification of positions with a transferring function.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... transferring function. 351.303 Section 351.303 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS REDUCTION IN FORCE Transfer of Function § 351.303 Identification of positions with a transferring function. (a) The competitive area losing the function is responsible for identifying the...

  17. Testate amoeba transfer function performance along localised hydrological gradients.

    PubMed

    Tsyganov, Andrey N; Mityaeva, Olga A; Mazei, Yuri A; Payne, Richard J

    2016-09-01

    Testate amoeba transfer functions are widely used for reconstruction of palaeo-hydrological regime in peatlands. However, the limitations of this approach have become apparent with increasing attention to validation and assessing sources of uncertainty. This paper investigates effects of peatland type and sampling depth on the performance of a transfer function using an independent test-set from four Sphagnum-dominated sites in European Russia (Penza Region). We focus on transfer function performance along localised hydrological gradients, which is a useful analogue for predictive ability through time. The performance of the transfer function with the independent test-set was generally weaker than for the leave-one-out or bootstrap cross-validations. However, the transfer function was robust for the reconstruction of relative changes in water-table depth, provided the presence of good modern analogues and overlap in water-table depth ranges. When applied to subsurface samples, the performance of the transfer function was reduced due to selective decomposition, the presence of deep-dwelling taxa or vertical transfer of shells. Our results stress the importance of thorough testing of transfer functions, and highlight the role of taphonomic processes in determining results. Further studies of stratification, taxonomy and taphonomy of testate amoebae will be needed to improve the robustness of transfer function output. Copyright © 2015 Elsevier GmbH. All rights reserved.

  18. Transfer function characteristics of super resolving systems

    NASA Technical Reports Server (NTRS)

    Milster, Tom D.; Curtis, Craig H.

    1992-01-01

    Signal quality in an optical storage device greatly depends on the optical system transfer function used to write and read data patterns. The problem is similar to analysis of scanning optical microscopes. Hopkins and Braat have analyzed write-once-read-many (WORM) optical data storage devices. Herein, transfer function analysis of magnetooptic (MO) data storage devices is discussed with respect to improving transfer-function characteristics. Several authors have described improving the transfer function as super resolution. However, none have thoroughly analyzed the MO optical system and effects of the medium. Both the optical system transfer function and effects of the medium of this development are discussed.

  19. Function Transfer in Human Operant Experiments: The Role of Stimulus Pairings

    ERIC Educational Resources Information Center

    Tonneau, Francois; Gonzalez, Carmen

    2004-01-01

    Although function transfer often has been studied in complex operant procedures (such as matching to sample), whether operant reinforcement actually produces function transfer in such settings has not been established. The present experiments, with high school students as subjects, suggest that stimulus pairings can promote function transfer in…

  20. Symbolic Regression for the Estimation of Transfer Functions of Hydrological Models

    NASA Astrophysics Data System (ADS)

    Klotz, D.; Herrnegger, M.; Schulz, K.

    2017-11-01

    Current concepts for parameter regionalization of spatially distributed rainfall-runoff models rely on the a priori definition of transfer functions that globally map land surface characteristics (such as soil texture, land use, and digital elevation) into the model parameter space. However, these transfer functions are often chosen ad hoc or derived from small-scale experiments. This study proposes and tests an approach for inferring the structure and parametrization of possible transfer functions from runoff data to potentially circumvent these difficulties. The concept uses context-free grammars to generate possible proposition for transfer functions. The resulting structure can then be parametrized with classical optimization techniques. Several virtual experiments are performed to examine the potential for an appropriate estimation of transfer function, all of them using a very simple conceptual rainfall-runoff model with data from the Austrian Mur catchment. The results suggest that a priori defined transfer functions are in general well identifiable by the method. However, the deduction process might be inhibited, e.g., by noise in the runoff observation data, often leading to transfer function estimates of lower structural complexity.

  1. First-and Second-Order Displacement Transfer Functions for Structural Shape Calculations Using Analytically Predicted Surface Strains

    NASA Technical Reports Server (NTRS)

    Ko, William L.; Fleischer, Van Tran

    2012-01-01

    New first- and second-order displacement transfer functions have been developed for deformed shape calculations of nonuniform cross-sectional beam structures such as aircraft wings. The displacement transfer functions are expressed explicitly in terms of beam geometrical parameters and surface strains (uniaxial bending strains) obtained at equally spaced strain stations along the surface of the beam structure. By inputting the measured or analytically calculated surface strains into the displacement transfer functions, one could calculate local slopes, deflections, and cross-sectional twist angles of the nonuniform beam structure for mapping the overall structural deformed shapes for visual display. The accuracy of deformed shape calculations by the first- and second-order displacement transfer functions are determined by comparing these values to the analytically predicted values obtained from finite element analyses. This comparison shows that the new displacement transfer functions could quite accurately calculate the deformed shapes of tapered cantilever tubular beams with different tapered angles. The accuracy of the present displacement transfer functions also are compared to those of the previously developed displacement transfer functions.

  2. Nonparametric Transfer Function Models

    PubMed Central

    Liu, Jun M.; Chen, Rong; Yao, Qiwei

    2009-01-01

    In this paper a class of nonparametric transfer function models is proposed to model nonlinear relationships between ‘input’ and ‘output’ time series. The transfer function is smooth with unknown functional forms, and the noise is assumed to be a stationary autoregressive-moving average (ARMA) process. The nonparametric transfer function is estimated jointly with the ARMA parameters. By modeling the correlation in the noise, the transfer function can be estimated more efficiently. The parsimonious ARMA structure improves the estimation efficiency in finite samples. The asymptotic properties of the estimators are investigated. The finite-sample properties are illustrated through simulations and one empirical example. PMID:20628584

  3. Trace metal in sediment from a deep-sea floor of Makassar Strait

    NASA Astrophysics Data System (ADS)

    Budianto, F.; Lestari

    2018-02-01

    Makassar Strait is located in the entrance of Indonesian Through Flow (ITF). However, the geochemistry of metals in sediment within Makassar Strait remains unexplored. The aim of this study was to measure the concentration of metals in sediment and to assess the sediment quality based on those metals concentrations. The sediment was collected from 632-4730 m in depth using giant piston corer on R/V Baruna Jaya VIII in December 2014. In each observation point, three layers of sediment were sub-sampled from the core i.e. surface layer (0-5 cm), middle layer (45-55 cm) and bottom layer. The metals were analyzed using acid digestion procedure followed by Atomic Absorption Spectrophotometer. The result indicated that the metal has spatially insignificant differences in sediment and the increase of metal concentration by depth was noticed. The Enrichment factor presented as no enrichment to minor enrichment of metal in sediment.

  4. Department of the Navy Justification of Estimates for Fiscal Years 1988 and 1989 Submitted to Congress January 1987. Operation & Maintenance, Navy. Book 1. Budget Activity 1. Strategic Forces Budget Activity 2. General Purpose Forces Budget Activity 4. Airlift and Sealift.

    DTIC Science & Technology

    1987-01-01

    166 174 170 167 Config Change Rqsts 45 54 53 52 Config Audits 20 26 26 25 Manual Change Rqsts 516 500 489 477 Work Years 91 90 90 90 7) Noise Reduction... manual methods. 771 ’ 1 1-50 3442f/7 Activity Group: Space Systems Operations (cont’d) AMOUNT C. Other Program Growth in FY 1989 (878) 1) Space...P+WS htp ~ h Na vy lr,(j Ma? itf’ to a nri rt. r 1’r f 1, Pri y t, i lu, iwe, a t ion, t a t H % ;, i rndi t 04 l I r k 4, PMfi , . j(I l j ,’Ř

  5. Closed-loop spontaneous baroreflex transfer function is inappropriate for system identification of neural arc but partly accurate for peripheral arc: predictability analysis

    PubMed Central

    Kamiya, Atsunori; Kawada, Toru; Shimizu, Shuji; Sugimachi, Masaru

    2011-01-01

    Abstract Although the dynamic characteristics of the baroreflex system have been described by baroreflex transfer functions obtained from open-loop analysis, the predictability of time-series output dynamics from input signals, which should confirm the accuracy of system identification, remains to be elucidated. Moreover, despite theoretical concerns over closed-loop system identification, the accuracy and the predictability of the closed-loop spontaneous baroreflex transfer function have not been evaluated compared with the open-loop transfer function. Using urethane and α-chloralose anaesthetized, vagotomized and aortic-denervated rabbits (n = 10), we identified open-loop baroreflex transfer functions by recording renal sympathetic nerve activity (SNA) while varying the vascularly isolated intracarotid sinus pressure (CSP) according to a binary random (white-noise) sequence (operating pressure ± 20 mmHg), and using a simplified equation to calculate closed-loop-spontaneous baroreflex transfer function while matching CSP with systemic arterial pressure (AP). Our results showed that the open-loop baroreflex transfer functions for the neural and peripheral arcs predicted the time-series SNA and AP outputs from measured CSP and SNA inputs, with r2 of 0.8 ± 0.1 and 0.8 ± 0.1, respectively. In contrast, the closed-loop-spontaneous baroreflex transfer function for the neural arc was markedly different from the open-loop transfer function (enhanced gain increase and a phase lead), and did not predict the time-series SNA dynamics (r2; 0.1 ± 0.1). However, the closed-loop-spontaneous baroreflex transfer function of the peripheral arc partially matched the open-loop transfer function in gain and phase functions, and had limited but reasonable predictability of the time-series AP dynamics (r2, 0.7 ± 0.1). A numerical simulation suggested that a noise predominantly in the neural arc under resting conditions might be a possible mechanism responsible for our findings. Furthermore, the predictabilities of the neural arc transfer functions obtained in open-loop and closed-loop conditions were validated by closed-loop pharmacological (phenylephrine and nitroprusside infusions) pressure interventions. Time-series SNA responses to drug-induced AP changes predicted by the open-loop transfer function matched closely the measured responses (r2, 0.9 ± 0.1), whereas SNA responses predicted by closed-loop-spontaneous transfer function deviated greatly and were the inverse of measured responses (r, −0.8 ± 0.2). These results indicate that although the spontaneous baroreflex transfer function obtained by closed-loop analysis has been believed to represent the neural arc function, it is inappropriate for system identification of the neural arc but is essentially appropriate for the peripheral arc under resting conditions, when compared with open-loop analysis. PMID:21486839

  6. Transfer of function and prior derived-relations testing.

    PubMed

    Doughty, Adam H; Best, Lauren

    2017-10-01

    This experiment assessed transfer of function through equivalence relations with and without prior derived-stimulus-relations (DSR) testing. In a DSR-Testing Group, eight college students learned A-B and A-C discriminations in baseline. They then derived the B-C and C-B equivalence relations before being exposed to a transfer-of-function manipulation and test. Eight participants in a No-DSR Testing Group were exposed to the transfer-of-function manipulation and test immediately after learning the baseline discriminations (i.e., B-C and C-B testing were omitted). In the transfer-of-function manipulation, participants learned to respond differently in the presence of B1 and B2 to avoid money loss. In the transfer-of-function test, responding in the presence of C1 and C2 was measured in the absence of differential consequences. Transfer of function occurred reliably only in the DSR-Testing Group (i.e., participants responding to C1 and C2 in the manner they learned to respond to B1 and B2, respectively). These findings support the notion that prior DSR testing can be critical to observing transfer of function. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. System and method of active vibration control for an electro-mechanically cooled device

    DOEpatents

    Lavietes, Anthony D.; Mauger, Joseph; Anderson, Eric H.

    2000-01-01

    A system and method of active vibration control of an electro-mechanically cooled device is disclosed. A cryogenic cooling system is located within an environment. The cooling system is characterized by a vibration transfer function, which requires vibration transfer function coefficients. A vibration controller generates the vibration transfer function coefficients in response to various triggering events. The environments may differ by mounting apparatus, by proximity to vibration generating devices, or by temperature. The triggering event may be powering on the cooling system, reaching an operating temperature, or a reset action. A counterbalance responds to a drive signal generated by the vibration controller, based on the vibration signal and the vibration transfer function, which adjusts vibrations. The method first places a cryogenic cooling system within a first environment and then generates a first set of vibration transfer function coefficients, for a vibration transfer function of the cooling system. Next, the cryogenic cooling system is placed within a second environment and a second set of vibration transfer function coefficients are generated. Then, a counterbalance is driven, based on the vibration transfer function, to reduce vibrations received by a vibration sensitive element.

  8. Transfer Function Identification Using Orthogonal Fourier Transform Modeling Functions

    NASA Technical Reports Server (NTRS)

    Morelli, Eugene A.

    2013-01-01

    A method for transfer function identification, including both model structure determination and parameter estimation, was developed and demonstrated. The approach uses orthogonal modeling functions generated from frequency domain data obtained by Fourier transformation of time series data. The method was applied to simulation data to identify continuous-time transfer function models and unsteady aerodynamic models. Model fit error, estimated model parameters, and the associated uncertainties were used to show the effectiveness of the method for identifying accurate transfer function models from noisy data.

  9. Multiconfiguration Pair-Density Functional Theory Outperforms Kohn-Sham Density Functional Theory and Multireference Perturbation Theory for Ground-State and Excited-State Charge Transfer.

    PubMed

    Ghosh, Soumen; Sonnenberger, Andrew L; Hoyer, Chad E; Truhlar, Donald G; Gagliardi, Laura

    2015-08-11

    The correct description of charge transfer in ground and excited states is very important for molecular interactions, photochemistry, electrochemistry, and charge transport, but it is very challenging for Kohn-Sham (KS) density functional theory (DFT). KS-DFT exchange-correlation functionals without nonlocal exchange fail to describe both ground- and excited-state charge transfer properly. We have recently proposed a theory called multiconfiguration pair-density functional theory (MC-PDFT), which is based on a combination of multiconfiguration wave function theory with a new type of density functional called an on-top density functional. Here we have used MC-PDFT to study challenging ground- and excited-state charge-transfer processes by using on-top density functionals obtained by translating KS exchange-correlation functionals. For ground-state charge transfer, MC-PDFT performs better than either the PBE exchange-correlation functional or CASPT2 wave function theory. For excited-state charge transfer, MC-PDFT (unlike KS-DFT) shows qualitatively correct behavior at long-range with great improvement in predicted excitation energies.

  10. Computer method for identification of boiler transfer functions

    NASA Technical Reports Server (NTRS)

    Miles, J. H.

    1971-01-01

    An iterative computer method is described for identifying boiler transfer functions using frequency response data. An objective penalized performance measure and a nonlinear minimization technique are used to cause the locus of points generated by a transfer function to resemble the locus of points obtained from frequency response measurements. Different transfer functions can be tried until a satisfactory empirical transfer function to the system is found. To illustrate the method, some examples and some results from a study of a set of data consisting of measurements of the inlet impedance of a single tube forced flow boiler with inserts are given.

  11. Role of sea surface wind stress forcing on transport between Tropical Pacific and Indian Ocean

    NASA Astrophysics Data System (ADS)

    Zhao, Q.

    Using an Indian-Pacific Ocean Circulation Model (IPOM) a simulation study on the Transports of between Tropical Pacific and Indian Ocean such as Indonesian Through flow (ITF) has been done. IPOM covered the area 25°E-70°W, 35°S-60°N. There are 31 levels in the vertical with 22 levels upper 400m in it. The horizontal resolution is 1/3° lat x 1.5° lon between 10°S and 10°N. The coastline and ocean topography of IPOM is prepared from Scripps topography data on 1x1°grid. Forcing IPOM with monthly observational wind stress in 1990-1999 the interannual variation of sea temperature has been reproduced well, not only on El Nino in the Pacific but also on Indian Ocean Dipole (IOD). Therefore, the oceanic circulations in the tropical ocean are reasonable. The analyses of the oceanic circulations from the simulations suggest that the transport southward through Makassar Strait is the primary route of thermocline water masses from the North Pacific to the Indonesian sea. The transport westward through Bali-Western Australian Transect (BWAT, at 117.5E) can be thought as the final output of ITF through the archipelago to Indian Ocean. The transport westward through BWAT is in 8-12S above 150m, its core centered near surface 10S, which looks like a jet. The westward velocity is more than 50 cm/s. The transport shows significant seasonal and interannual variations. The maximum is in Jul-Oct, minimum in Jan-Mar. These results are consistent with some observation basically. The correlation analyses indict that the variations of transport westward is related with the southeasterly anomaly in the east tropical Indian ocean. The transport variation lags wind anomaly about 3 months. The correlation coefficient is more than 0.6. The transport is strong during IOD, for example in 1994 and 1997. The variations are also related with the northwesterly anomaly in the center equatorial Pacific and the easterly in the eastern equatorial Pacific. The transport is strong in most ENSO events. The above results suggest the sea surface wind stress from satellite is widely useful.

  12. Consistent Parameter and Transfer Function Estimation using Context Free Grammars

    NASA Astrophysics Data System (ADS)

    Klotz, Daniel; Herrnegger, Mathew; Schulz, Karsten

    2017-04-01

    This contribution presents a method for the inference of transfer functions for rainfall-runoff models. Here, transfer functions are defined as parametrized (functional) relationships between a set of spatial predictors (e.g. elevation, slope or soil texture) and model parameters. They are ultimately used for estimation of consistent, spatially distributed model parameters from a limited amount of lumped global parameters. Additionally, they provide a straightforward method for parameter extrapolation from one set of basins to another and can even be used to derive parameterizations for multi-scale models [see: Samaniego et al., 2010]. Yet, currently an actual knowledge of the transfer functions is often implicitly assumed. As a matter of fact, for most cases these hypothesized transfer functions can rarely be measured and often remain unknown. Therefore, this contribution presents a general method for the concurrent estimation of the structure of transfer functions and their respective (global) parameters. Note, that by consequence an estimation of the distributed parameters of the rainfall-runoff model is also undertaken. The method combines two steps to achieve this. The first generates different possible transfer functions. The second then estimates the respective global transfer function parameters. The structural estimation of the transfer functions is based on the context free grammar concept. Chomsky first introduced context free grammars in linguistics [Chomsky, 1956]. Since then, they have been widely applied in computer science. But, to the knowledge of the authors, they have so far not been used in hydrology. Therefore, the contribution gives an introduction to context free grammars and shows how they can be constructed and used for the structural inference of transfer functions. This is enabled by new methods from evolutionary computation, such as grammatical evolution [O'Neill, 2001], which make it possible to exploit the constructed grammar as a search space for equations. The parametrization of the transfer functions is then achieved through a second optimization routine. The contribution explores different aspects of the described procedure through a set of experiments. These experiments can be divided into three categories: (1) The inference of transfer functions from directly measurable parameters; (2) The estimation of global parameters for given transfer functions from runoff data; and (3) The estimation of sets of completely unknown transfer functions from runoff data. The conducted tests reveal different potentials and limits of the procedure. In concrete it is shown that example (1) and (2) work remarkably well. Example (3) is much more dependent on the setup. In general, it can be said that in that case much more data is needed to derive transfer function estimations, even for simple models and setups. References: - Chomsky, N. (1956): Three Models for the Description of Language. IT IRETr. 2(3), p 113-124 - O'Neil, M. (2001): Grammatical Evolution. IEEE ToEC, Vol.5, No. 4 - Samaniego, L.; Kumar, R.; Attinger, S. (2010): Multiscale parameter regionalization of a grid-based hydrologic model at the mesoscale. WWR, Vol. 46, W05523, doi:10.1029/2008WR007327

  13. Artificial Neural Network with Hardware Training and Hardware Refresh

    NASA Technical Reports Server (NTRS)

    Duong, Tuan A. (Inventor)

    2003-01-01

    A neural network circuit is provided having a plurality of circuits capable of charge storage. Also provided is a plurality of circuits each coupled to at least one of the plurality of charge storage circuits and constructed to generate an output in accordance with a neuron transfer function. Each of a plurality of circuits is coupled to one of the plurality of neuron transfer function circuits and constructed to generate a derivative of the output. A weight update circuit updates the charge storage circuits based upon output from the plurality of transfer function circuits and output from the plurality of derivative circuits. In preferred embodiments, separate training and validation networks share the same set of charge storage circuits and may operate concurrently. The validation network has a separate transfer function circuits each being coupled to the charge storage circuits so as to replicate the training network s coupling of the plurality of charge storage to the plurality of transfer function circuits. The plurality of transfer function circuits may be constructed each having a transconductance amplifier providing differential currents combined to provide an output in accordance with a transfer function. The derivative circuits may have a circuit constructed to generate a biased differential currents combined so as to provide the derivative of the transfer function.

  14. Identification of boiler inlet transfer functions and estimation of system parameters

    NASA Technical Reports Server (NTRS)

    Miles, J. H.

    1972-01-01

    An iterative computer method is described for identifying boiler transfer functions using frequency response data. An objective penalized performance measure and a nonlinear minimization technique are used to cause the locus of points generated by a transfer function to resemble the locus of points obtained from frequency response measurements. Different transfer functions can be tried until a satisfactory empirical transfer function of the system is found. To illustrate the method, some examples and some results from a study of a set of data consisting of measurements of the inlet impedance of a single tube forced flow boiler with inserts are given.

  15. Computer method for identification of boiler transfer functions

    NASA Technical Reports Server (NTRS)

    Miles, J. H.

    1972-01-01

    Iterative computer aided procedure was developed which provides for identification of boiler transfer functions using frequency response data. Method uses frequency response data to obtain satisfactory transfer function for both high and low vapor exit quality data.

  16. Proceedings and findings of the 1976 Workshop on Ride Quality. [passenger acceptance of transportation systems

    NASA Technical Reports Server (NTRS)

    Kuhlthau, A. R. (Editor)

    1976-01-01

    The workshop was organized around the study of the three basic transfer functions required to evaluate and/or predict passenger acceptance of transportation systems: These are the vehicle, passenger, and value transfer functions. For the purpose of establishing working groups corresponding to the basic transfer functions, it was decided to split the vehicle transfer function into two distinct groups studying surface vehicles and air/marine vehicles, respectively.

  17. 5 CFR 351.302 - Transfer of employees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... is not identified with an operating function specifically authorized at the time of transfer to... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Transfer of employees. 351.302 Section... FORCE Transfer of Function § 351.302 Transfer of employees. (a) Before a reduction in force is made in...

  18. 5 CFR 351.302 - Transfer of employees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... is not identified with an operating function specifically authorized at the time of transfer to... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Transfer of employees. 351.302 Section... FORCE Transfer of Function § 351.302 Transfer of employees. (a) Before a reduction in force is made in...

  19. 5 CFR 351.302 - Transfer of employees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... is not identified with an operating function specifically authorized at the time of transfer to... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Transfer of employees. 351.302 Section... FORCE Transfer of Function § 351.302 Transfer of employees. (a) Before a reduction in force is made in...

  20. 5 CFR 351.302 - Transfer of employees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... is not identified with an operating function specifically authorized at the time of transfer to... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Transfer of employees. 351.302 Section... FORCE Transfer of Function § 351.302 Transfer of employees. (a) Before a reduction in force is made in...

  1. 5 CFR 351.302 - Transfer of employees.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... is not identified with an operating function specifically authorized at the time of transfer to... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Transfer of employees. 351.302 Section... FORCE Transfer of Function § 351.302 Transfer of employees. (a) Before a reduction in force is made in...

  2. Nerve transfers in tetraplegia I: Background and technique

    PubMed Central

    Brown, Justin M.

    2011-01-01

    Background: The recovery of hand function is consistently rated as the highest priority for persons with tetraplegia. Recovering even partial arm and hand function can have an enormous impact on independence and quality of life of an individual. Currently, tendon transfers are the accepted modality for improving hand function. In this procedure, the distal end of a functional muscle is cut and reattached at the insertion site of a nonfunctional muscle. The tendon transfer sacrifices the function at a lesser location to provide function at a more important location. Nerve transfers are conceptually similar to tendon transfers and involve cutting and connecting a healthy but less critical nerve to a more important but paralyzed nerve to restore its function. Methods: We present a case of a 28-year-old patient with a C5-level ASIA B (international classification level 1) injury who underwent nerve transfers to restore arm and hand function. Intact peripheral innervation was confirmed in the paralyzed muscle groups corresponding to finger flexors and extensors, wrist flexors and extensors, and triceps bilaterally. Volitional control and good strength were present in the biceps and brachialis muscles, the deltoid, and the trapezius. The patient underwent nerve transfers to restore finger flexion and extension, wrist flexion and extension, and elbow extension. Intraoperative motor-evoked potentials and direct nerve stimulation were used to identify donor and recipient nerve branches. Results: The patient tolerated the procedure well, with a preserved function in both elbow flexion and shoulder abduction. Conclusions: Nerve transfers are a technically feasible means of restoring the upper extremity function in tetraplegia in cases that may not be amenable to tendon transfers. PMID:21918736

  3. Transfer function concept for ultrasonic characterization of material microstructures

    NASA Technical Reports Server (NTRS)

    Vary, A.; Kautz, H. E.

    1986-01-01

    The approach given depends on treating material microstructures as elastomechanical filters that have analytically definable transfer functions. These transfer functions can be defined in terms of the frequency dependence of the ultrasonic attenuation coefficient. The transfer function concept provides a basis for synthesizing expressions that characterize polycrystalline materials relative to microstructural factors such as mean grain size, grain-size distribution functions, and grain boundary energy transmission. Although the approach is nonrigorous, it leads to a rational basis for combining the previously mentioned diverse and fragmented equations for ultrasonic attenuation coefficients.

  4. VALIDATION OF BENEFIT-TRANSFER FUNCTIONS

    EPA Science Inventory

    1. Identification of benefit-transfer functions that are the most credible. 2. Identification of benefit-transfer issues that are related to transfer method and those related to data limitations. 3. Clarification of issues t...

  5. Mitochondrial Retroprocessing Promoted Functional Transfers of rpl5 to the Nucleus in Grasses.

    PubMed

    Wu, Zhiqiang; Sloan, Daniel B; Brown, Colin W; Rosenblueth, Mónica; Palmer, Jeffrey D; Ong, Han Chuan

    2017-09-01

    Functional gene transfers from the mitochondrion to the nucleus are ongoing in angiosperms and have occurred repeatedly for all 15 ribosomal protein genes, but it is not clear why some of these genes are transferred more often than others nor what the balance is between DNA- and RNA-mediated transfers. Although direct insertion of mitochondrial DNA into the nucleus occurs frequently in angiosperms, case studies of functional mitochondrial gene transfer have implicated an RNA-mediated mechanism that eliminates introns and RNA editing sites, which would otherwise impede proper expression of mitochondrial genes in the nucleus. To elucidate the mechanisms that facilitate functional gene transfers and the evolutionary dynamics of the coexisting nuclear and mitochondrial gene copies that are established during these transfers, we have analyzed rpl5 genes from 90 grasses (Poaceae) and related monocots. Multiple lines of evidence indicate that rpl5 has been functionally transferred to the nucleus at least three separate times in the grass family and that at least seven species have intact and transcribed (but not necessarily functional) copies in both the mitochondrion and nucleus. In two grasses, likely functional nuclear copies of rpl5 have been subject to recent gene conversion events via secondarily transferred mitochondrial copies in what we believe are the first described cases of mitochondrial-to-nuclear gene conversion. We show that rpl5 underwent a retroprocessing event within the mitochondrial genome early in the evolution of the grass family, which we argue predisposed the gene towards successful, DNA-mediated functional transfer by generating a "pre-edited" sequence. © The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  6. Fast computation of the electrolyte-concentration transfer function of a lithium-ion cell model

    NASA Astrophysics Data System (ADS)

    Rodríguez, Albert; Plett, Gregory L.; Trimboli, M. Scott

    2017-08-01

    One approach to creating physics-based reduced-order models (ROMs) of battery-cell dynamics requires first generating linearized Laplace-domain transfer functions of all cell internal electrochemical variables of interest. Then, the resulting infinite-dimensional transfer functions can be reduced by various means in order to find an approximate low-dimensional model. These methods include Padé approximation or the Discrete-Time Realization algorithm. In a previous article, Lee and colleagues developed a transfer function of the electrolyte concentration for a porous-electrode pseudo-two-dimensional lithium-ion cell model. Their approach used separation of variables and Sturm-Liouville theory to compute an infinite-series solution to the transfer function, which they then truncated to a finite number of terms for reasons of practicality. Here, we instead use a variation-of-parameters approach to arrive at a different representation of the identical solution that does not require a series expansion. The primary benefits of the new approach are speed of computation of the transfer function and the removal of the requirement to approximate the transfer function by truncating the number of terms evaluated. Results show that the speedup of the new method can be more than 3800.

  7. The transfer functions of cardiac tissue during stochastic pacing.

    PubMed

    de Lange, Enno; Kucera, Jan P

    2009-01-01

    The restitution properties of cardiac action potential duration (APD) and conduction velocity (CV) are important factors in arrhythmogenesis. They determine alternans, wavebreak, and the patterns of reentrant arrhythmias. We developed a novel approach to characterize restitution using transfer functions. Transfer functions relate an input and an output quantity in terms of gain and phase shift in the complex frequency domain. We derived an analytical expression for the transfer function of interbeat intervals (IBIs) during conduction from one site (input) to another site downstream (output). Transfer functions can be efficiently obtained using a stochastic pacing protocol. Using simulations of conduction and extracellular mapping of strands of neonatal rat ventricular myocytes, we show that transfer functions permit the quantification of APD and CV restitution slopes when it is difficult to measure APD directly. We find that the normally positive CV restitution slope attenuates IBI variations. In contrast, a negative CV restitution slope (induced by decreasing extracellular [K(+)]) amplifies IBI variations with a maximum at the frequency of alternans. Hence, it potentiates alternans and renders conduction unstable, even in the absence of APD restitution. Thus, stochastic pacing and transfer function analysis represent a powerful strategy to evaluate restitution and the stability of conduction.

  8. Treatment of peroneal nerve injuries with simultaneous tendon transfer and nerve exploration.

    PubMed

    Ho, Bryant; Khan, Zubair; Switaj, Paul J; Ochenjele, George; Fuchs, Daniel; Dahl, William; Cederna, Paul; Kung, Theodore A; Kadakia, Anish R

    2014-08-06

    Common peroneal nerve palsy leading to foot drop is difficult to manage and has historically been treated with extended bracing with expectant waiting for return of nerve function. Peroneal nerve exploration has traditionally been avoided except in cases of known traumatic or iatrogenic injury, with tendon transfers being performed in a delayed fashion after exhausting conservative treatment. We present a new strategy for management of foot drop with nerve exploration and concomitant tendon transfer. We retrospectively reviewed a series of 12 patients with peroneal nerve palsies that were treated with tendon transfer from 2005 to 2011. Of these patients, seven were treated with simultaneous peroneal nerve exploration and repair at the time of tendon transfer. Patients with both nerve repair and tendon transfer had superior functional results with active dorsiflexion in all patients, compared to dorsiflexion in 40% of patients treated with tendon transfers alone. Additionally, 57% of patients treated with nerve repair and tendon transfer were able to achieve enough function to return to running, compared to 20% in patients with tendon transfer alone. No patient had full return of native motor function resulting in excessive dorsiflexion strength. The results of our limited case series for this rare condition indicate that simultaneous nerve repair and tendon transfer showed no detrimental results and may provide improved function over tendon transfer alone.

  9. Causal transfer function analysis to describe closed loop interactions between cardiovascular and cardiorespiratory variability signals.

    PubMed

    Faes, L; Porta, A; Cucino, R; Cerutti, S; Antolini, R; Nollo, G

    2004-06-01

    Although the concept of transfer function is intrinsically related to an input-output relationship, the traditional and widely used estimation method merges both feedback and feedforward interactions between the two analyzed signals. This limitation may endanger the reliability of transfer function analysis in biological systems characterized by closed loop interactions. In this study, a method for estimating the transfer function between closed loop interacting signals was proposed and validated in the field of cardiovascular and cardiorespiratory variability. The two analyzed signals x and y were described by a bivariate autoregressive model, and the causal transfer function from x to y was estimated after imposing causality by setting to zero the model coefficients representative of the reverse effects from y to x. The method was tested in simulations reproducing linear open and closed loop interactions, showing a better adherence of the causal transfer function to the theoretical curves with respect to the traditional approach in presence of non-negligible reverse effects. It was then applied in ten healthy young subjects to characterize the transfer functions from respiration to heart period (RR interval) and to systolic arterial pressure (SAP), and from SAP to RR interval. In the first two cases, the causal and non-causal transfer function estimates were comparable, indicating that respiration, acting as exogenous signal, sets an open loop relationship upon SAP and RR interval. On the contrary, causal and traditional transfer functions from SAP to RR were significantly different, suggesting the presence of a considerable influence on the opposite causal direction. Thus, the proposed causal approach seems to be appropriate for the estimation of parameters, like the gain and the phase lag from SAP to RR interval, which have a large clinical and physiological relevance.

  10. Nerve Transfers for Improved Hand Function Following Cervical Spinal Cord Injury

    DTIC Science & Technology

    the cervical spine resulting in diminished or complete loss of arm and/or hand function. Cervical SCI patients consistently rank hand function as the...most desired function above bowel and bladder function, sexual function, standing, and pain control. The overall goal of the proposed study is to...evaluate the efficacy of nerve transfers to treat patients with cervical SCIs. Over the last decade, nerve transfers have been used with increasing

  11. Influence of acoustic impedance of multilayer acoustic systems on the transfer function of ultrasonic airborne transducers.

    PubMed

    Gudra, Tadeusz; Opieliński, Krzysztof J

    2002-05-01

    In different solutions of ultrasonic transducers radiating acoustic energy into the air there occurs the problem of the proper selection of the acoustic impedance of one or more matching layers. The goal of this work was a computer analysis of the influence of acoustic impedance on the transfer function of piezoceramic transducers equipped with matching layers. Cases of resonance and non-resonance matching impedance in relation to the transfer function and the energy transmission coefficient for solid state-air systems were analysed. With stable thickness of matching layers the required shape of the transfer function can be obtained through proper choice of acoustic impedance were built (e.g. maximal flat function). The proper choice of acoustic impedance requires an elaboration of precise methods of synthesis of matching systems. Using the known matching criteria (Chebyshev's, DeSilets', Souquet's), the transfer function characteristics of transducers equipped with one, two, and three matching layers as well as the optimisation methods of the energy transmission coefficient were presented. The influence of the backside load of the transducer on the shape of transfer function was also analysed. The calculation results of this function for different loads of the transducer backside without and with the different matching layers were presented. The proper load selection allows us to obtain the desired shape of the transfer function, which determines the pulse shape generated by the transducer.

  12. Significance of a Recurring Function in Energy Transfer

    NASA Astrophysics Data System (ADS)

    Mishra, Subodha

    2017-05-01

    The appearance of a unique function in the energy transfer from one system to the other in different physical situations such as electrical, mechanical, optical, and quantum mechanical processes is established in this work. Though the laws governing the energy transformation and its transfer from system to system are well known, here we notice a unity in diversity; a unique function appears in various cases of energy transfer whether it is a classical or a quantum mechanical process. We consider four examples, well known in elementary physics, from the fields of electricity, mechanics, optics, and quantum mechanics. We find that this unique function is in fact the transfer function corresponding to all these physical situations, and the interesting and intriguing finding is that the inverse Laplace transform of this transfer function, which is the impulse-response function of the systems when multiplied by a factor of -½, is the solution of a linear differential equation for an "instantly forced critically damped harmonic oscillator." It is important to note that though the physical phenomena considered are quite distinct, the underlying process in the language of impulse-response of the system in the time domain is a unique one. To the best of our knowledge we have not seen anywhere the above analysis of determining the unique function or its description as a transfer function in literature.

  13. Using nerve transfer to restore prehension and grasp 12 years following spinal cord injury: a case report.

    PubMed

    Fox, Ida K; Novak, Christine B; Kahn, Lorna C; Mackinnon, Susan E; Ruvinskaya, Rimma; Juknis, Neringa

    2018-01-01

    Nerve transfers are used routinely for reconstruction of hand function following lower motor neuron lesions. In people with cervical spinal cord injury (SCI), this novel and alternate reconstruction option may be useful to restore prehension and grasp, and improve hand function. A 34-year-old male presented 12 years post-mid-cervical SCI. Pre-operative electrodiagnostic studies revealed intact lower motor neurons below the SCI level. He elected to undergo nerve transfer surgery to restore hand function. Intraoperative evaluation led to the transfer of a brachialis nerve to several median nerve recipient branches. Post surgery, he was discharged home and resumed activities of daily living. He achieved independent thumb and finger flexion function and continued to exhibit functional improvement at 4 years post surgery. These results should prompt referral for consideration of nerve transfer surgery-an exciting alternative to tendon transfer and neuroprostheses.

  14. Experimental Waterflow Determination of the Dynamic Hydraulic Transfer Function for the J-2X Oxidizer Turbopump. Part Two; Results and Interpretation

    NASA Technical Reports Server (NTRS)

    Zoladz, Tom; Patel, Sandeep; Lee, Erik; Karon, Dave

    2011-01-01

    Experimental results describing the hydraulic dynamic pump transfer matrix (Yp) for a cavitating J-2X oxidizer turbopump inducer+impeller tested in subscale waterflow are presented. The transfer function is required for integrated vehicle pogo stability analysis as well as optimization of local inducer pumping stability. Dynamic transfer functions across widely varying pump hydrodynamic inlet conditions are extracted from measured data in conjunction with 1D-model based corrections. Derived Dynamic transfer functions are initially interpreted relative to traditional Pogo pump equations. Water-to-liquid oxygen scaling of measured cavitation characteristics are discussed. Comparison of key dynamic transfer matrix terms derived from waterflow testing are made with those implemented in preliminary Ares Upper Stage Pogo stability modeling. Alternate cavitating pump hydraulic dynamic equations are suggested which better reflect frequency dependencies of measured transfer matrices.

  15. Development of a Dynamic Visco-elastic Vehicle-Soil Interaction Model for Rut Depth, and Power Determinations

    DTIC Science & Technology

    2011-09-06

    Presentation Outline A) Review of Soil Model governing equations B) Development of pedo -transfer functions (terrain database to engineering properties) C...lateral earth pressure) UNCLASSIFIED B) Development of pedo -transfer functions Engineering parameters needed by soil model - compression index - rebound...inches, RCI for fine- grained soils, CI for coarse-grained soils. UNCLASSIFIED Pedo -transfer function • Need to transfer existing terrain database

  16. Adaptive Same Frequency Repeater (SFR) Study

    DTIC Science & Technology

    1976-03-01

    Formulation 13 (2) Evaluation of the Steady State Weights!.’.’.’!.*!!."!! 21 (3) Evaluation of the Composite Transfer Function.... 2^ (4) Simplified...well as possible the amplitude and phase of the composite coupling path. Because the coupling paths have frequency-dependent transfer functions...34), (35) and the notch filter and channel transfer .’unctions (3fi) and (39). The composite transfer function Hc(f ’ ^’.f) is then found and

  17. Image Processing, Coding, and Compression with Multiple-Point Impulse Response Functions.

    NASA Astrophysics Data System (ADS)

    Stossel, Bryan Joseph

    1995-01-01

    Aspects of image processing, coding, and compression with multiple-point impulse response functions are investigated. Topics considered include characterization of the corresponding random-walk transfer function, image recovery for images degraded by the multiple-point impulse response, and the application of the blur function to image coding and compression. It is found that although the zeros of the real and imaginary parts of the random-walk transfer function occur in continuous, closed contours, the zeros of the transfer function occur at isolated spatial frequencies. Theoretical calculations of the average number of zeros per area are in excellent agreement with experimental results obtained from computer counts of the zeros. The average number of zeros per area is proportional to the standard deviations of the real part of the transfer function as well as the first partial derivatives. Statistical parameters of the transfer function are calculated including the mean, variance, and correlation functions for the real and imaginary parts of the transfer function and their corresponding first partial derivatives. These calculations verify the assumptions required in the derivation of the expression for the average number of zeros. Interesting results are found for the correlations of the real and imaginary parts of the transfer function and their first partial derivatives. The isolated nature of the zeros in the transfer function and its characteristics at high spatial frequencies result in largely reduced reconstruction artifacts and excellent reconstructions are obtained for distributions of impulses consisting of 25 to 150 impulses. The multiple-point impulse response obscures original scenes beyond recognition. This property is important for secure transmission of data on many communication systems. The multiple-point impulse response enables the decoding and restoration of the original scene with very little distortion. Images prefiltered by the random-walk transfer function yield greater compression ratios than are obtained for the original scene. The multiple-point impulse response decreases the bit rate approximately 40-70% and affords near distortion-free reconstructions. Due to the lossy nature of transform-based compression algorithms, noise reduction measures must be incorporated to yield acceptable reconstructions after decompression.

  18. Description, Analysis and Simulation of a New Realization of Digital Filters.

    DTIC Science & Technology

    1987-09-01

    together with its staircase representation h,.(t) . ..... .. ... ... .. 79 6.3 The-RDC LPF transfer function when Td includes 2 zeroes of hc(t) 81 6.4 The...RDC LPF transfer function when Td includes 6 zeroes of hc(t) 82 6.5 The RDC LPF transfer function when Td includes 8 zeroes of h,(t) 83 6.6 The RDC LPF...transfer function when Td includes 6 zeroes of h,(t) and when rectangular and Hamming windows are used ........ ... 84 6.7 The input z(t) and its

  19. a Middle-Ear Reverse Transfer Function Computed from Vibration Measurements of Otoacoustic Emissions on the Ear Drum of the Guinea PIG

    NASA Astrophysics Data System (ADS)

    Dalhoff, Ernst; Turcanu, Diana; Gummer, Anthony W.

    2009-02-01

    Using distortion products measured as vibration of the umbo and as sound pressure in the ear canal of guinea pigs, we calculated the corresponding reverse transfer function. We compare the measurements with a middle-ear model taken from the literature and adapted to the guinea pig. A reasonable fit could be achieved. We conclude that the reverse transfer function will be useful to aid fitting a middle-ear model to measured transfer functions of human subjects.

  20. Transfer Function Bounds for Partial-unit-memory Convolutional Codes Based on Reduced State Diagram

    NASA Technical Reports Server (NTRS)

    Lee, P. J.

    1984-01-01

    The performance of a coding system consisting of a convolutional encoder and a Viterbi decoder is analytically found by the well-known transfer function bounding technique. For the partial-unit-memory byte-oriented convolutional encoder with m sub 0 binary memory cells and (k sub 0 m sub 0) inputs, a state diagram of 2(K) (sub 0) was for the transfer function bound. A reduced state diagram of (2 (m sub 0) +1) is used for easy evaluation of transfer function bounds for partial-unit-memory codes.

  1. Determining A Purely Symbolic Transfer Function from Symbol Streams: Theory and Algorithms

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Griffin, Christopher H

    Transfer function modeling is a \\emph{standard technique} in classical Linear Time Invariant and Statistical Process Control. The work of Box and Jenkins was seminal in developing methods for identifying parameters associated with classicalmore » $(r,s,k)$$ transfer functions. Discrete event systems are often \\emph{used} for modeling hybrid control structures and high-level decision problems. \\emph{Examples include} discrete time, discrete strategy repeated games. For these games, a \\emph{discrete transfer function in the form of} an accurate hidden Markov model of input-output relations \\emph{could be used to derive optimal response strategies.} In this paper, we develop an algorithm \\emph{for} creating probabilistic \\textit{Mealy machines} that act as transfer function models for discrete event dynamic systems (DEDS). Our models are defined by three parameters, $$(l_1, l_2, k)$ just as the Box-Jenkins transfer function models. Here $$l_1$$ is the maximal input history lengths to consider, $$l_2$$ is the maximal output history lengths to consider and $k$ is the response lag. Using related results, We show that our Mealy machine transfer functions are optimal in the sense that they maximize the mutual information between the current known state of the DEDS and the next observed input/output pair.« less

  2. Digital control algorithms for microgravity isolation systems

    NASA Technical Reports Server (NTRS)

    Sinha, Alok; Wang, Yung-Peng

    1992-01-01

    New digital control algorithms were developed to achieve the desired acceleration transmissibility function. The attractive electromagnets have been taken as actuators. The relative displacement and the acceleration of the mass were used as feedback signals. Two approaches were developed to find that controller transfer function in Z-domain, which yields the desired transmissibility at each frequency. In the first approach, the controller transfer function is obtained by assuming that the desired transmissibility is known in Z-domain. Since the desired transmissibility H sub d(S) = 1/(tauS+1)(exp 2) is given in S-domain, the first task is to obtain the desired transmissibility in Z-domain. There are three methods to perform this task: bilinear transformation, and backward and forward rectangular rules. The bilinear transformation and backward rectangular rule lead to improper controller transfer functions, which are physically not realizable. The forward rectangular rule does lead to a physically realizable controller. However, this controller is found to be marginally stable because of a pole at Z=1. In order to eliminate this pole, a hybrid control structure is proposed. Here the control input is composed of two parts: analog and digital. The analog input simply represents the velocity (or the integral of acceleration) feedback; and the digital controller which uses only relative displacement signal, is then obtained to achieve the desired closed-loop transfer function. The stability analysis indicates that the controller transfer function is stable for typical values of sampling period. In the second approach, the aforementioned hybrid control structure is again used. First, an analog controller transfer function corresponding to relative displacement feedback is obtained to achieve the transmissibility as 1/(tauS+1)(exp 2). Then the transfer function for the digital control input is obtained by discretizing this analog controller transfer function via bilinear transformation. The stability of the resulting Z-domain closed loop system is analyzed. Also, the frequency response of the Z-domain closed-loop transfer function is determined to evaluate the performance of the control system.

  3. Rehabilitation, Using Guided Cerebral Plasticity, of a Brachial Plexus Injury Treated with Intercostal and Phrenic Nerve Transfers.

    PubMed

    Dahlin, Lars B; Andersson, Gert; Backman, Clas; Svensson, Hampus; Björkman, Anders

    2017-01-01

    Recovery after surgical reconstruction of a brachial plexus injury using nerve grafting and nerve transfer procedures is a function of peripheral nerve regeneration and cerebral reorganization. A 15-year-old boy, with traumatic avulsion of nerve roots C5-C7 and a non-rupture of C8-T1, was operated 3 weeks after the injury with nerve transfers: (a) terminal part of the accessory nerve to the suprascapular nerve, (b) the second and third intercostal nerves to the axillary nerve, and (c) the fourth to sixth intercostal nerves to the musculocutaneous nerve. A second operation-free contralateral gracilis muscle transfer directly innervated by the phrenic nerve-was done after 2 years due to insufficient recovery of the biceps muscle function. One year later, electromyography showed activation of the biceps muscle essentially with coughing through the intercostal nerves, and of the transferred gracilis muscle by deep breathing through the phrenic nerve. Voluntary flexion of the elbow elicited clear activity in the biceps/gracilis muscles with decreasing activity in intercostal muscles distal to the transferred intercostal nerves (i.e., corresponding to eighth intercostal), indicating cerebral plasticity, where neural control of elbow flexion is gradually separated from control of breathing. To restore voluntary elbow function after nerve transfers, the rehabilitation of patients operated with intercostal nerve transfers should concentrate on transferring coughing function, while patients with phrenic nerve transfers should focus on transferring deep breathing function.

  4. Completion of Launch Director Console Project and Other Support Work

    NASA Technical Reports Server (NTRS)

    Steinrock, Joshua G.

    2018-01-01

    There were four projects that I was a part of working on during the spring semester of 2018. This included the completion of the Launch Director Console (LDC) project and the completion and submission of a Concept of Operations (ConOps) document for the Record and Playback System (RPS) at the Launch Control Center (LCC), as well as supporting the implementation of a unit in RPS known as the CDP (Communication Data Processor). Also included was my support and mentorship of a High School robotics team that is sponsored by Kennedy Space Center. The LDC project is an innovative workstation to be used by the launch director for the future Space Launch System program. I worked on the fabrication and assembly of the final console. The ConOps on RPS is a technical document for which I produced supporting information and notes. All of this was done in the support of the IT Project Management Office (IT-F). The CDP is a subsystem that will eventually be installed in and operated by RPS.

  5. Current and future medical treatments for patients with acromegaly.

    PubMed

    Maffezzoni, Filippo; Formenti, Anna Maria; Mazziotti, Gherardo; Frara, Stefano; Giustina, Andrea

    2016-08-01

    Acromegaly is a relatively rare condition of growth hormone (GH) excess associated with significant morbidity and, when left untreated, high mortality. Therapy for acromegaly is targeted at decreasing GH and insulin-like growth hormone 1 levels, ameliorating patients' symptoms and decreasing any local compressive effects of the pituitary adenoma. The therapeutic options for acromegaly include surgery, medical therapies (such as dopamine agonists, somatostatin receptor ligands and the GH receptor antagonist pegvisomant) and radiotherapy. However, despite all these treatments option, approximately 50% of patients are not adequately controlled. In this paper, the authors discuss: 1) efficacy and safety of current medical therapy 2) the efficacy and safety of the new multireceptor-targeted somatostatin ligand pasireotide 3) medical treatments currently under clinical investigation (oral octreotide, ITF2984, ATL1103), and 4) preliminary data on the use of new injectable and transdermal/transmucosal formulations of octreotide. This expert opinion supports the need for new therapeutic agents and modalities for patients with acromegaly.

  6. Enhancements to the SSME transfer function modeling code

    NASA Technical Reports Server (NTRS)

    Irwin, R. Dennis; Mitchell, Jerrel R.; Bartholomew, David L.; Glenn, Russell D.

    1995-01-01

    This report details the results of a one year effort by Ohio University to apply the transfer function modeling and analysis tools developed under NASA Grant NAG8-167 (Irwin, 1992), (Bartholomew, 1992) to attempt the generation of Space Shuttle Main Engine High Pressure Turbopump transfer functions from time domain data. In addition, new enhancements to the transfer function modeling codes which enhance the code functionality are presented, along with some ideas for improved modeling methods and future work. Section 2 contains a review of the analytical background used to generate transfer functions with the SSME transfer function modeling software. Section 2.1 presents the 'ratio method' developed for obtaining models of systems that are subject to single unmeasured excitation sources and have two or more measured output signals. Since most of the models developed during the investigation use the Eigensystem Realization Algorithm (ERA) for model generation, Section 2.2 presents an introduction of ERA, and Section 2.3 describes how it can be used to model spectral quantities. Section 2.4 details the Residue Identification Algorithm (RID) including the use of Constrained Least Squares (CLS) and Total Least Squares (TLS). Most of this information can be found in the report (and is repeated for convenience). Section 3 chronicles the effort of applying the SSME transfer function modeling codes to the a51p394.dat and a51p1294.dat time data files to generate transfer functions from the unmeasured input to the 129.4 degree sensor output. Included are transfer function modeling attempts using five methods. The first method is a direct application of the SSME codes to the data files and the second method uses the underlying trends in the spectral density estimates to form transfer function models with less clustering of poles and zeros than the models obtained by the direct method. In the third approach, the time data is low pass filtered prior to the modeling process in an effort to filter out high frequency characteristics. The fourth method removes the presumed system excitation and its harmonics in order to investigate the effects of the excitation on the modeling process. The fifth method is an attempt to apply constrained RID to obtain better transfer functions through more accurate modeling over certain frequency ranges. Section 4 presents some new C main files which were created to round out the functionality of the existing SSME transfer function modeling code. It is now possible to go from time data to transfer function models using only the C codes; it is not necessary to rely on external software. The new C main files and instructions for their use are included. Section 5 presents current and future enhancements to the XPLOT graphics program which was delivered with the initial software. Several new features which have been added to the program are detailed in the first part of this section. The remainder of Section 5 then lists some possible features which may be added in the future. Section 6 contains the conclusion section of this report. Section 6.1 is an overview of the work including a summary and observations relating to finding transfer functions with the SSME code. Section 6.2 contains information relating to future work on the project.

  7. SAR Processing Based On Two-Dimensional Transfer Function

    NASA Technical Reports Server (NTRS)

    Chang, Chi-Yung; Jin, Michael Y.; Curlander, John C.

    1994-01-01

    Exact transfer function, ETF, is two-dimensional transfer function that constitutes basis of improved frequency-domain-convolution algorithm for processing synthetic-aperture-radar, SAR data. ETF incorporates terms that account for Doppler effect of motion of radar relative to scanned ground area and for antenna squint angle. Algorithm based on ETF outperforms others.

  8. Propagation of eigenmodes and transfer functions in waveguide WDM structures

    NASA Astrophysics Data System (ADS)

    Mashkov, Vladimir A.; Francoeur, S.; Geuss, U.; Neiser, K.; Temkin, Henryk

    1998-02-01

    A method of propagation functions and transfer amplitudes suitable for the design of integrated optical circuits is presented. The method is based on vectorial formulation of electrodynamics: the distributions and propagation of electromagnetic fields in optical circuits is described by equivalent surface sources. This approach permits a division of complex optical waveguide structures into sets of primitive blocks and to separately calculate the transfer function and the transfer amplitude for each block. The transfer amplitude of the entire optical system is represented by a convolution of transfer amplitudes of its primitive blocks. The eigenvalues and eigenfunctions of arbitrary waveguide structure are obtained in the WKB approximation and compared with other methods. The general approach is illustrated with the transfer amplitude calculations for Dragone's star coupler and router.

  9. Spatially Controlled Noncovalent Functionalization of 2D Materials Based on Molecular Architecture.

    PubMed

    Bang, Jae Jin; Porter, Ashlin G; Davis, Tyson C; Hayes, Tyler R; Claridge, Shelley A

    2018-05-15

    Polymerizable amphiphiles can be assembled into lying-down phases on 2D materials such as graphite and graphene to create chemically orthogonal surface patterns at 5-10 nm scales, locally modulating functionality of the 2D basal plane. Functionalization can be carried out through Langmuir-Schaefer conversion, in which a subset of molecules is transferred out of a standing phase film on water onto the 2D substrate. Here, we leverage differences in molecular structure to spatially control transfer at both nanoscopic and microscopic scales. We compare transfer properties of five different single- and dual-chain amphiphiles, demonstrating that those with strong lateral interactions (e.g., hydrogen-bonding networks) exhibit the lowest transfer efficiencies. Since molecular structures also influence microscopic domain morphologies in Langmuir films, we show that it is possible to transfer such microscale patterns, taking advantage of variations in the local transfer rates based on the structural heterogeneity in Langmuir films. Nanoscale domain morphologies also vary in ways that are consistent with predicted relative transfer and diffusion rates. These results suggest strategies to tailor noncovalent functionalization of 2D substrates through controlled LS transfer.

  10. The influence of a wall function on turbine blade heat transfer prediction

    NASA Technical Reports Server (NTRS)

    Whitaker, Kevin W.

    1989-01-01

    The second phase of a continuing investigation to improve the prediction of turbine blade heat transfer coefficients was completed. The present study specifically investigated how a numeric wall function in the turbulence model of a two-dimensional boundary layer code, STAN5, affected heat transfer prediction capabilities. Several sources of inaccuracy in the wall function were identified and then corrected or improved. Heat transfer coefficient predictions were then obtained using each one of the modifications to determine its effect. Results indicated that the modifications made to the wall function can significantly affect the prediction of heat transfer coefficients on turbine blades. The improvement in accuracy due the modifications is still inconclusive and is still being investigated.

  11. Performance of Frozen Density Embedding for Modeling Hole Transfer Reactions.

    PubMed

    Ramos, Pablo; Papadakis, Markos; Pavanello, Michele

    2015-06-18

    We have carried out a thorough benchmark of the frozen density-embedding (FDE) method for calculating hole transfer couplings. We have considered 10 exchange-correlation functionals, 3 nonadditive kinetic energy functionals, and 3 basis sets. Overall, we conclude that with a 7% mean relative unsigned error, the PBE and PW91 functionals coupled with the PW91k nonadditive kinetic energy functional and a TZP basis set constitute the most stable and accurate levels of theory for hole transfer coupling calculations. The FDE-ET method is found to be an excellent tool for computing diabatic couplings for hole transfer reactions.

  12. Improved Displacement Transfer Functions for Structure Deformed Shape Predictions Using Discretely Distributed Surface Strains

    NASA Technical Reports Server (NTRS)

    Ko, William L.; Fleischer, Van Tran

    2012-01-01

    In the formulations of earlier Displacement Transfer Functions for structure shape predictions, the surface strain distributions, along a strain-sensing line, were represented with piecewise linear functions. To improve the shape-prediction accuracies, Improved Displacement Transfer Functions were formulated using piecewise nonlinear strain representations. Through discretization of an embedded beam (depth-wise cross section of a structure along a strain-sensing line) into multiple small domains, piecewise nonlinear functions were used to describe the surface strain distributions along the discretized embedded beam. Such piecewise approach enabled the piecewise integrations of the embedded beam curvature equations to yield slope and deflection equations in recursive forms. The resulting Improved Displacement Transfer Functions, written in summation forms, were expressed in terms of beam geometrical parameters and surface strains along the strain-sensing line. By feeding the surface strains into the Improved Displacement Transfer Functions, structural deflections could be calculated at multiple points for mapping out the overall structural deformed shapes for visual display. The shape-prediction accuracies of the Improved Displacement Transfer Functions were then examined in view of finite-element-calculated deflections using different tapered cantilever tubular beams. It was found that by using the piecewise nonlinear strain representations, the shape-prediction accuracies could be greatly improved, especially for highly-tapered cantilever tubular beams.

  13. Derived Manding in Children with Autism: Synthesizing Skinner's Verbal Behavior with Relational Frame Theory

    PubMed Central

    2005-01-01

    Mand functions for two stimuli (A1 and A2) were trained for 3 children with autism and were then incorporated into two related conditional discriminations (A1-B1/A2 -B2 and B1-C1/B2-C2). Tests were conducted to probe for a derived transfer of mand response functions from A1 and A2 to C1 and C2, respectively. When 1 participant failed to demonstrate derived transfer of mand response functions, transfer training using exemplars was conducted. When participants had demonstrated derived transfer of mand functions, the X1 and X2 tokens that were employed as reinforcers for mand responses were incorporated into two conditional discriminations (X1-Y1/X2-Y2 and Y1-Z1/Y2-Z2). Tests were conducted for derived transfer of reinforcing functions. Finally, tests were conducted to determine if the participants would demonstrate derived manding for the derived reinforcers (present C1 and C2 to mand for Z1 and Z2, respectively). Derived transfer of functions was observed when the sequence of training and testing was reversed (i.e., training and testing reinforcing functions before mand response functions) and when only minimal instructions were provided. PMID:16463526

  14. On the role of covarying functions in stimulus class formation and transfer of function.

    PubMed Central

    Markham, Rebecca G; Markham, Michael R

    2002-01-01

    This experiment investigated whether directly trained covarying functions are necessary for stimulus class formation and transfer of function in humans. Initial class training was designed to establish two respondent-based stimulus classes by pairing two visual stimuli with shock and two other visual stimuli with no shock. Next, two operant discrimination functions were trained to one stimulus of each putative class. The no-shock group received the same training and testing in all phases, except no stimuli were ever paired with shock. The data indicated that skin conductance response conditioning did not occur for the shock groups or for the no-shock group. Tests showed transfer of the established discriminative functions, however, only for the shock groups, indicating the formation of two stimulus classes only for those participants who received respondent class training. The results suggest that transfer of function does not depend on first covarying the stimulus class functions. PMID:12507017

  15. Automatic transfer function design for medical visualization using visibility distributions and projective color mapping.

    PubMed

    Cai, Lile; Tay, Wei-Liang; Nguyen, Binh P; Chui, Chee-Kong; Ong, Sim-Heng

    2013-01-01

    Transfer functions play a key role in volume rendering of medical data, but transfer function manipulation is unintuitive and can be time-consuming; achieving an optimal visualization of patient anatomy or pathology is difficult. To overcome this problem, we present a system for automatic transfer function design based on visibility distribution and projective color mapping. Instead of assigning opacity directly based on voxel intensity and gradient magnitude, the opacity transfer function is automatically derived by matching the observed visibility distribution to a target visibility distribution. An automatic color assignment scheme based on projective mapping is proposed to assign colors that allow for the visual discrimination of different structures, while also reflecting the degree of similarity between them. When our method was tested on several medical volumetric datasets, the key structures within the volume were clearly visualized with minimal user intervention. Copyright © 2013 Elsevier Ltd. All rights reserved.

  16. Evaluation of nerve transfer options for treating total brachial plexus avulsion injury: a retrospective study of 73 participants

    PubMed Central

    Gao, Kai-ming; Hu, Jing-jing; Lao, Jie; Zhao, Xin

    2018-01-01

    Despite recent great progress in diagnosis and microsurgical repair, the prognosis in total brachial plexus-avulsion injury remains unfavorable. Insufficient number of donors and unreasonable use of donor nerves might be key factors. To identify an optimal treatment strategy for this condition, we conducted a retrospective review. Seventy-three patients with total brachial plexus avulsion injury were followed up for an average of 7.3 years. Our analysis demonstrated no significant difference in elbow-flexion recovery between phrenic nerve-transfer (25 cases), phrenic nerve-graft (19 cases), intercostal nerve (17 cases), or contralateral C7-transfer (12 cases) groups. Restoration of shoulder function was attempted through anterior accessory nerve (27 cases), posterior accessory nerve (10 cases), intercostal nerve (5 cases), or accessory + intercostal nerve transfer (31 cases). Accessory nerve + intercostal nerve transfer was the most effective method. A significantly greater amount of elbow extension was observed in patients with intercostal nerve transfer (25 cases) than in those with contralateral C7 transfer (10 cases). Recovery of median nerve function was noticeably better for those who received entire contralateral C7 transfer (33 cases) than for those who received partial contralateral C7 transfer (40 cases). Wrist and finger extension were reconstructed by intercostal nerve transfer (31 cases). Overall, the recommended surgical treatment for total brachial plexus-avulsion injury is phrenic nerve transfer for elbow flexion, accessory nerve + intercostal nerve transfer for shoulder function, intercostal nerves transfer for elbow extension, entire contralateral C7 transfer for median nerve function, and intercostal nerve transfer for finger extension. The trial was registered at ClinicalTrials.gov (identifier: NCT03166033). PMID:29623932

  17. Evaluation of nerve transfer options for treating total brachial plexus avulsion injury: A retrospective study of 73 participants.

    PubMed

    Gao, Kai-Ming; Hu, Jing-Jing; Lao, Jie; Zhao, Xin

    2018-03-01

    Despite recent great progress in diagnosis and microsurgical repair, the prognosis in total brachial plexus-avulsion injury remains unfavorable. Insufficient number of donors and unreasonable use of donor nerves might be key factors. To identify an optimal treatment strategy for this condition, we conducted a retrospective review. Seventy-three patients with total brachial plexus avulsion injury were followed up for an average of 7.3 years. Our analysis demonstrated no significant difference in elbow-flexion recovery between phrenic nerve-transfer (25 cases), phrenic nerve-graft (19 cases), intercostal nerve (17 cases), or contralateral C 7 -transfer (12 cases) groups. Restoration of shoulder function was attempted through anterior accessory nerve (27 cases), posterior accessory nerve (10 cases), intercostal nerve (5 cases), or accessory + intercostal nerve transfer (31 cases). Accessory nerve + intercostal nerve transfer was the most effective method. A significantly greater amount of elbow extension was observed in patients with intercostal nerve transfer (25 cases) than in those with contralateral C 7 transfer (10 cases). Recovery of median nerve function was noticeably better for those who received entire contralateral C 7 transfer (33 cases) than for those who received partial contralateral C 7 transfer (40 cases). Wrist and finger extension were reconstructed by intercostal nerve transfer (31 cases). Overall, the recommended surgical treatment for total brachial plexus-avulsion injury is phrenic nerve transfer for elbow flexion, accessory nerve + intercostal nerve transfer for shoulder function, intercostal nerves transfer for elbow extension, entire contralateral C 7 transfer for median nerve function, and intercostal nerve transfer for finger extension. The trial was registered at ClinicalTrials.gov (identifier: NCT03166033).

  18. 5 CFR 630.212 - Use of annual leave to establish initial eligibility for retirement or continuation of health...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... decline relocation (including transfer of function). (b)(1) Annual leave that may be used for the purposes... transfer of function) and annual leave earned by an employee while in a paid leave status after the effective date of the reduction in force or relocation (including transfer of function). (2) Annual leave...

  19. Dispersion relations of elastic waves in one-dimensional piezoelectric/piezomagnetic phononic crystal with functionally graded interlayers.

    PubMed

    Guo, Xiao; Wei, Peijun; Lan, Man; Li, Li

    2016-08-01

    The effects of functionally graded interlayers on dispersion relations of elastic waves in a one-dimensional piezoelectric/piezomagnetic phononic crystal are studied in this paper. First, the state transfer equation of the functionally graded interlayer is derived from the motion equation by the reduction of order (from second order to first order). The transfer matrix of the functionally graded interlayer is obtained by solving the state transfer equation with the spatial-varying coefficient. Based on the transfer matrixes of the piezoelectric slab, the piezomagnetic slab and the functionally graded interlayers, the total transfer matrix of a single cell is obtained. Further, the Bloch theorem is used to obtain the resultant dispersion equations of in-plane and anti-plane Bloch waves. The dispersion equations are solved numerically and the numerical results are shown graphically. Five kinds of profiles of functionally graded interlayers between a piezoelectric slab and a piezomagnetic slab are considered. It is shown that the functionally graded interlayers have evident influences on the dispersion curves and the band gaps. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. Variable-Domain Displacement Transfer Functions for Converting Surface Strains into Deflections for Structural Deformed Shape Predictions

    NASA Technical Reports Server (NTRS)

    Ko, William L.; Fleischer, Van Tran

    2015-01-01

    Variable-Domain Displacement Transfer Functions were formulated for shape predictions of complex wing structures, for which surface strain-sensing stations must be properly distributed to avoid jointed junctures, and must be increased in the high strain gradient region. Each embedded beam (depth-wise cross section of structure along a surface strain-sensing line) was discretized into small variable domains. Thus, the surface strain distribution can be described with a piecewise linear or a piecewise nonlinear function. Through discretization, the embedded beam curvature equation can be piece-wisely integrated to obtain the Variable-Domain Displacement Transfer Functions (for each embedded beam), which are expressed in terms of geometrical parameters of the embedded beam and the surface strains along the strain-sensing line. By inputting the surface strain data into the Displacement Transfer Functions, slopes and deflections along each embedded beam can be calculated for mapping out overall structural deformed shapes. A long tapered cantilever tubular beam was chosen for shape prediction analysis. The input surface strains were analytically generated from finite-element analysis. The shape prediction accuracies of the Variable- Domain Displacement Transfer Functions were then determined in light of the finite-element generated slopes and deflections, and were fofound to be comparable to the accuracies of the constant-domain Displacement Transfer Functions

  1. Modified Displacement Transfer Functions for Deformed Shape Predictions of Slender Curved Structures with Varying Curvatives

    NASA Technical Reports Server (NTRS)

    Ko, William L.; Fleischer, Van Tran

    2014-01-01

    To eliminate the need to use finite-element modeling for structure shape predictions, a new method was invented. This method is to use the Displacement Transfer Functions to transform the measured surface strains into deflections for mapping out overall structural deformed shapes. The Displacement Transfer Functions are expressed in terms of rectilinearly distributed surface strains, and contain no material properties. This report is to apply the patented method to the shape predictions of non-symmetrically loaded slender curved structures with different curvatures up to a full circle. Because the measured surface strains are not available, finite-element analysis had to be used to analytically generate the surface strains. Previously formulated straight-beam Displacement Transfer Functions were modified by introducing the curvature-effect correction terms. Through single-point or dual-point collocations with finite-elementgenerated deflection curves, functional forms of the curvature-effect correction terms were empirically established. The resulting modified Displacement Transfer Functions can then provide quite accurate shape predictions. Also, the uniform straight-beam Displacement Transfer Function was applied to the shape predictions of a section-cut of a generic capsule (GC) outer curved sandwich wall. The resulting GC shape predictions are quite accurate in partial regions where the radius of curvature does not change sharply.

  2. A Non-parametric Approach to Constrain the Transfer Function in Reverberation Mapping

    NASA Astrophysics Data System (ADS)

    Li, Yan-Rong; Wang, Jian-Min; Bai, Jin-Ming

    2016-11-01

    Broad emission lines of active galactic nuclei stem from a spatially extended region (broad-line region, BLR) that is composed of discrete clouds and photoionized by the central ionizing continuum. The temporal behaviors of these emission lines are blurred echoes of continuum variations (I.e., reverberation mapping, RM) and directly reflect the structures and kinematic information of BLRs through the so-called transfer function (also known as the velocity-delay map). Based on the previous works of Rybicki and Press and Zu et al., we develop an extended, non-parametric approach to determine the transfer function for RM data, in which the transfer function is expressed as a sum of a family of relatively displaced Gaussian response functions. Therefore, arbitrary shapes of transfer functions associated with complicated BLR geometry can be seamlessly included, enabling us to relax the presumption of a specified transfer function frequently adopted in previous studies and to let it be determined by observation data. We formulate our approach in a previously well-established framework that incorporates the statistical modeling of continuum variations as a damped random walk process and takes into account long-term secular variations which are irrelevant to RM signals. The application to RM data shows the fidelity of our approach.

  3. Nominal and functional task difficulty in skill acquisition: Effects on performance in two tests of transfer.

    PubMed

    Sanli, Elizabeth A; Lee, Timothy D

    2015-06-01

    The influence of nominal and functional task difficulty during the acquisition of a motor skill was examined in two tests of transfer of learning. The task involved a ballistic, target-directed, finger action. Nominal task difficulty was defined as the distance of the target from the home position. Functional task difficulty was created by manipulating the progression of target distances during practice. Based on the challenge point framework (Guadagnoli & Lee, 2004), we predicted that practice with a set of targets farther away from the performer would benefit from less functional task difficulty, while practice with a closer set of targets would benefit from more functional task difficulty. In single-task transfer tests, learners who practiced using the high nominal task difficulty targets benefitted in terms of persistence of performance over time. In dual-task transfer tests, groups with an intermediate combined (nominal and functional) task difficulty performed with greater persistence over time on tests of transfer than those who practiced with the highest or lowest combined difficulty. Together these findings suggest that the influences of nominal and functional task difficulty during acquisition are weighted differentially depending upon the transfer test context. The challenge point framework does not accurately capture this complex relationship in its current form. Copyright © 2015 Elsevier B.V. All rights reserved.

  4. Toe-to-hand transfer in symbrachydactyly.

    PubMed

    Richardson, Philip W F; Johnstone, Bruce R; Coombs, Christopher J

    2004-07-01

    Symbrachydactyly, or central atypical cleft, is classified as a failure of formation. For the adactylous or monodactylous forms, free toe transfer is the treatment of choice. We present 18 free toe transfers in 13 patients for symbrachydactyly. Despite abnormal anatomy, the functional building blocks have always been available and transfer technically possible. The result has been improved function and high levels of parental satisfaction.

  5. DISTRIBUTED RC NETWORKS WITH RATIONAL TRANSFER FUNCTIONS,

    DTIC Science & Technology

    A distributed RC circuit analogous to a continuously tapped transmission line can be made to have a rational short-circuit transfer admittance and...one rational shortcircuit driving-point admittance. A subcircuit of the same structure has a rational open circuit transfer impedance and one rational ...open circuit driving-point impedance. Hence, rational transfer functions may be obtained while considering either generator impedance or load

  6. Mission analysis for cross-site transfer

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Riesenweber, S.D.; Fritz, R.L.; Shipley, L.E.

    1995-11-01

    The Mission Analysis Report describes the requirements and constraints associated with the Transfer Waste Function as necessary to support the Manage Tank Waste, Retrieve Waste, and Process Tank Waste Functions described in WHC-SD-WM-FRD-020, Tank Waste Remediation System (TWRS) Functions and Requirements Document and DOE/RL-92-60, Revision 1, TWRS Functions and Requirements Document, March 1994. It further assesses the ability of the ``initial state`` (or current cross-site transfer system) to meet the requirements and constraints.

  7. Thunder-induced ground motions: 1. Observations

    NASA Astrophysics Data System (ADS)

    Lin, Ting-L.; Langston, Charles A.

    2009-04-01

    Acoustic pressure from thunder and its induced ground motions were investigated using a small array consisting of five three-component short-period surface seismometers, a three-component borehole seismometer, and five infrasound microphones. We used the array to constrain wave parameters of the incident acoustic and seismic waves. The incident slowness differences between acoustic pressure and ground motions suggest that ground reverberations were first initiated somewhat away from the array. Using slowness inferred from ground motions is preferable to obtain the seismic source parameters. We propose a source equalization procedure for acoustic/seismic deconvolution to generate the time domain transfer function, a procedure similar to that of obtaining teleseismic earthquake receiver functions. The time domain transfer function removes the incident pressure time history from the seismogram. An additional vertical-to-radial ground motion transfer function was used to identify the Rayleigh wave propagation mode of induced seismic waves complementing that found using the particle motions and amplitude variations in the borehole. The initial motions obtained by the time domain transfer functions suggest a low Poisson's ratio for the near-surface layer. The acoustic-to-seismic transfer functions show a consistent reverberation series at frequencies near 5 Hz. This gives an empirical measure of site resonance that depends on the ratio of the layer velocity to layer thickness for earthquake P and S waves. The time domain transfer function approach by transferring a spectral division into the time domain provides an alternative method for studying acoustic-to-seismic coupling.

  8. Functional Latissimus Dorsi Transfer for Upper-Extremity Reconstruction: A Case Report and Review of the Literature.

    PubMed

    Sood, Aditya; Therattil, Paul J; Russo, Gerardo; Lee, Edward S

    2017-01-01

    Objective: The latissimus dorsi flap is a workhorse for plastic surgeons, being used for many years for soft-tissue coverage of the upper extremity as well as for functional reconstruction to restore motion to the elbow and shoulder. The authors present a case of functional latissimus dorsi transfer for restoration of elbow flexion and review the literature on technique and outcomes. Methods: A literature review was performed using MEDLINE and the Cochrane Collaboration Library for primary research articles on functional latissimus dorsi flap transfer. Data related to surgical techniques and outcomes were extracted. Results: The literature search yielded 13 relevant studies, with a total of 52 patients who received pedicled, functional latissimus dorsi flaps for upper-extremity reconstruction. The most common etiology requiring reconstruction was closed brachial plexus injury (n = 13). After flap transfer, 98% of patients were able to flex the elbow against gravity and 82.3% were able to flex against resistance. In the presented case, a 77-year-old man underwent resection of myxofibrosarcoma of the upper arm with elbow prosthesis placement and functional latissimus dorsi transfer. The patient was able to actively flex against gravity at 3-month follow-up. Conclusions: A review of the literature shows that nearly all patients undergoing functional latissimus dorsi transfer for upper-extremity reconstruction regain at least motion against gravity whereas a large proportion regain motion against resistance. Considerations when planning for functional latissimus dorsi transfer include patient positioning, appropriate tensioning of the muscle, safe inset, polarity, management of other affected upper-extremity joints, and educating patients on the expected outcomes.

  9. Functional Latissimus Dorsi Transfer for Upper-Extremity Reconstruction: A Case Report and Review of the Literature

    PubMed Central

    Therattil, Paul J.; Russo, Gerardo; Lee, Edward S.

    2017-01-01

    Objective: The latissimus dorsi flap is a workhorse for plastic surgeons, being used for many years for soft-tissue coverage of the upper extremity as well as for functional reconstruction to restore motion to the elbow and shoulder. The authors present a case of functional latissimus dorsi transfer for restoration of elbow flexion and review the literature on technique and outcomes. Methods: A literature review was performed using MEDLINE and the Cochrane Collaboration Library for primary research articles on functional latissimus dorsi flap transfer. Data related to surgical techniques and outcomes were extracted. Results: The literature search yielded 13 relevant studies, with a total of 52 patients who received pedicled, functional latissimus dorsi flaps for upper-extremity reconstruction. The most common etiology requiring reconstruction was closed brachial plexus injury (n = 13). After flap transfer, 98% of patients were able to flex the elbow against gravity and 82.3% were able to flex against resistance. In the presented case, a 77-year-old man underwent resection of myxofibrosarcoma of the upper arm with elbow prosthesis placement and functional latissimus dorsi transfer. The patient was able to actively flex against gravity at 3-month follow-up. Conclusions: A review of the literature shows that nearly all patients undergoing functional latissimus dorsi transfer for upper-extremity reconstruction regain at least motion against gravity whereas a large proportion regain motion against resistance. Considerations when planning for functional latissimus dorsi transfer include patient positioning, appropriate tensioning of the muscle, safe inset, polarity, management of other affected upper-extremity joints, and educating patients on the expected outcomes. PMID:28293330

  10. Nerve Transfers to Restore Shoulder Function.

    PubMed

    Leechavengvongs, Somsak; Malungpaishorpe, Kanchai; Uerpairojkit, Chairoj; Ng, Chye Yew; Witoonchart, Kiat

    2016-05-01

    The restoration of shoulder function after brachial plexus injury represents a significant challenge facing the peripheral nerve surgeons. This is owing to a combination of the complex biomechanics of the shoulder girdle, the multitude of muscles and nerves that could be potentially injured, and a limited number of donor options. In general, nerve transfer is favored over tendon transfer, because the biomechanics of the musculotendinous units are not altered. This article summarizes the surgical techniques and clinical results of nerve transfers for restoration of shoulder function. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. Completion processing for data communications instructions

    DOEpatents

    Blocksome, Michael A.; Kumar, Sameer; Parker, Jeffrey J.

    2014-06-03

    Completion processing of data communications instructions in a distributed computing environment, including receiving, in an active messaging interface (`AMI`) data communications instructions, at least one instruction specifying a callback function; injecting into an injection FIFO buffer of a data communication adapter, an injection descriptor, each slot in the injection FIFO buffer having a corresponding slot in a pending callback list; listing in the pending callback list any callback function specified by an instruction, incrementing a pending callback counter for each listed callback function; transferring payload data as per each injection descriptor, incrementing a transfer counter upon completion of each transfer; determining from counter values whether the pending callback list presently includes callback functions whose data transfers have been completed; calling by the AMI any such callback functions from the pending callback list, decrementing the pending callback counter for each callback function called.

  12. Förster-Induced Energy Transfer in Functionalized Graphene

    PubMed Central

    2014-01-01

    Carbon nanostructures are ideal substrates for functionalization with molecules since they consist of a single atomic layer giving rise to an extraordinary sensitivity to changes in their surrounding. The functionalization opens a new research field of hybrid nanostructures with tailored properties. Here, we present a microscopic view on the substrate–molecule interaction in the exemplary hybrid material consisting of graphene functionalized with perylene molecules. First experiments on similar systems have been recently realized illustrating an extremely efficient transfer of excitation energy from adsorbed molecules to the carbon substrate, a process with a large application potential for high-efficiency photovoltaic devices and biomedical imaging and sensing. So far, there has been no microscopically founded explanation for the observed energy transfer. Based on first-principle calculations, we have explicitly investigated the different transfer mechanisms revealing the crucial importance of Förster coupling. Due to the efficient Coulomb interaction in graphene, we obtain strong Förster rates in the range of 1/fs. We investigate its dependence on the substrate–molecule distance R and describe the impact of the momentum transfer q for an efficient energy transfer. Furthermore, we find that the Dexter transfer mechanism is negligibly small due to the vanishing overlap between the involved strongly localized orbital functions. The gained insights are applicable to a variety of carbon-based hybrid nanostructures. PMID:24808936

  13. Hydrophobic and optical characteristics of graphene and graphene oxide films transferred onto functionalized silica particles deposited glass surface

    NASA Astrophysics Data System (ADS)

    Yilbas, B. S.; Ibrahim, A.; Ali, H.; Khaled, M.; Laoui, T.

    2018-06-01

    Hydrophobic and optical transmittance characteristics of the functionalized silica particles on the glass surface prior and after transfer of graphene and graphene oxide films on the surface are examined. Nano-size silica particles are synthesized and functionalized via chemical grafting and deposited onto a glass surface. Graphene film, grown on copper substrate, was transferred onto the functionalized silica particles surface through direct fishing method. Graphene oxide layer was deposited onto the functionalized silica particles surface via spin coating technique. Morphological, hydrophobic, and optical characteristics of the functionalized silica particles deposited surface prior and after graphene and graphene oxide films transfer are examined using the analytical tools. It is found that the functionalized silica particles are agglomerated at the surface forming packed structures with few micro/nano size pores. This arrangement gives rise to water droplet contact angle and contact angle hysteresis in the order of 163° and 2°, respectively, and remains almost uniform over the entire surface. Transferring graphene and depositing graphene oxide films over the functionalized silica particles surface lowers the water droplet contact angle slightly (157-160°) and increases the contact angle hysteresis (4°). The addition of the graphene and graphene oxide films onto the surface of the deposited functionalized silica particles improves the optical transmittance.

  14. Crosstalk Cancellation for a Simultaneous Phase Shifting Interferometer

    NASA Technical Reports Server (NTRS)

    Olczak, Eugene (Inventor)

    2014-01-01

    A method of minimizing fringe print-through in a phase-shifting interferometer, includes the steps of: (a) determining multiple transfer functions of pixels in the phase-shifting interferometer; (b) computing a crosstalk term for each transfer function; and (c) displaying, to a user, a phase-difference map using the crosstalk terms computed in step (b). Determining a transfer function in step (a) includes measuring intensities of a reference beam and a test beam at the pixels, and measuring an optical path difference between the reference beam and the test beam at the pixels. Computing crosstalk terms in step (b) includes computing an N-dimensional vector, where N corresponds to the number of transfer functions, and the N-dimensional vector is obtained by minimizing a variance of a modulation function in phase shifted images.

  15. Comparison of Regression Analysis and Transfer Function in Estimating the Parameters of Central Pulse Waves from Brachial Pulse Wave.

    PubMed

    Chai, Rui; Xu, Li-Sheng; Yao, Yang; Hao, Li-Ling; Qi, Lin

    2017-01-01

    This study analyzed ascending branch slope (A_slope), dicrotic notch height (Hn), diastolic area (Ad) and systolic area (As) diastolic blood pressure (DBP), systolic blood pressure (SBP), pulse pressure (PP), subendocardial viability ratio (SEVR), waveform parameter (k), stroke volume (SV), cardiac output (CO), and peripheral resistance (RS) of central pulse wave invasively and non-invasively measured. Invasively measured parameters were compared with parameters measured from brachial pulse waves by regression model and transfer function model. Accuracy of parameters estimated by regression and transfer function model, was compared too. Findings showed that k value, central pulse wave and brachial pulse wave parameters invasively measured, correlated positively. Regression model parameters including A_slope, DBP, SEVR, and transfer function model parameters had good consistency with parameters invasively measured. They had same effect of consistency. SBP, PP, SV, and CO could be calculated through the regression model, but their accuracies were worse than that of transfer function model.

  16. Analyzing Community College Student Transfer Rates.

    ERIC Educational Resources Information Center

    Cohen, Arthur M.

    The community college mission includes such diverse goals as preparing students for job entry, teaching literacy, and satisfying students' personal interests. Measuring the colleges' transfer rates by no means tacitly elevates the transfer function above these other functions; it merely helps institutions estimate the effects of interventions on…

  17. Laser induced forward transfer of graphene

    NASA Astrophysics Data System (ADS)

    Smits, Edsger C. P.; Walter, Arnaud; de Leeuw, Dago M.; Asadi, Kamal

    2017-10-01

    Transfer of graphene and other two-dimensional materials is still a technical challenge. The 2D-materials are typically patterned after transfer, which leads to a major loss of material. Here, we present laser induced forward transfer of chemical vapor deposition grown graphene layers with well-defined shapes and geometries. The transfer is based on photo-decomposition of a triazene-based transfer layer that produces N2 gas, which propels a graphene layer from the donor to the acceptor substrate. The functionality of the graphene-metal junction was verified by realizing functional bottom contact bottom gate field-effect transistors.

  18. Study of Anti-Vortex Baffle Effect in Suppressing Swirling Flow in LOX Tank

    NASA Technical Reports Server (NTRS)

    Yang, H. Q.; Peugeot, John

    2011-01-01

    Experimental results describing the hydraulic dynamic pump transfer matrix (Yp) for a cavitating J-2X oxidizer turbopump inducer+impeller tested in subscale waterflow are presented. The transfer function is required for integrated vehicle pogo stability analysis as well as optimization of local inducer pumping stability. Dynamic transfer functions across widely varying pump hydrodynamic inlet conditions are extracted from measured data in conjunction with 1D-model based corrections. Derived Dynamic transfer functions are initially interpreted relative to traditional Pogo pump equations. Water-to-liquid oxygen scaling of measured cavitation characteristics are discussed. Comparison of key dynamic transfer matrix terms derived from waterflow testing are made with those implemented in preliminary Ares Upper Stage Pogo stability modeling. Alternate cavitating pump hydraulic dynamic equations are suggested which better reflect frequency dependencies of measured transfer matrices.

  19. How to precisely measure the volume velocity transfer function of physical vocal tract models by external excitation

    PubMed Central

    Mainka, Alexander; Kürbis, Steffen; Birkholz, Peter

    2018-01-01

    Recently, 3D printing has been increasingly used to create physical models of the vocal tract with geometries obtained from magnetic resonance imaging. These printed models allow measuring the vocal tract transfer function, which is not reliably possible in vivo for the vocal tract of living humans. The transfer functions enable the detailed examination of the acoustic effects of specific articulatory strategies in speaking and singing, and the validation of acoustic plane-wave models for realistic vocal tract geometries in articulatory speech synthesis. To measure the acoustic transfer function of 3D-printed models, two techniques have been described: (1) excitation of the models with a broadband sound source at the glottis and measurement of the sound pressure radiated from the lips, and (2) excitation of the models with an external source in front of the lips and measurement of the sound pressure inside the models at the glottal end. The former method is more frequently used and more intuitive due to its similarity to speech production. However, the latter method avoids the intricate problem of constructing a suitable broadband glottal source and is therefore more effective. It has been shown to yield a transfer function similar, but not exactly equal to the volume velocity transfer function between the glottis and the lips, which is usually used to characterize vocal tract acoustics. Here, we revisit this method and show both, theoretically and experimentally, how it can be extended to yield the precise volume velocity transfer function of the vocal tract. PMID:29543829

  20. Completion processing for data communications instructions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Blocksome, Michael A; Kumar, Sameer; Parker, Jeffrey J

    Completion processing of data communications instructions in a distributed computing environment, including receiving, in an active messaging interface (`AMI`) data communications instructions, at least one instruction specifying a callback function; injecting into an injection FIFO buffer of a data communication adapter, an injection descriptor, each slot in the injection FIFO buffer having a corresponding slot in a pending callback list; listing in the pending callback list any callback function specified by an instruction, incrementing a pending callback counter for each listed callback function; transferring payload data as per each injection descriptor, incrementing a transfer counter upon completion of each transfer;more » determining from counter values whether the pending callback list presently includes callback functions whose data transfers have been completed; calling by the AMI any such callback functions from the pending callback list, decrementing the pending callback counter for each callback function called.« less

  1. Parametric dependence of ocean wave-radar modulation transfer functions

    NASA Technical Reports Server (NTRS)

    Plant, W. J.; Keller, W. C.; Cross, A.

    1983-01-01

    Microwave techniques at X and L band were used to determine the dependence of ocean-wave radar modulation transfer functions (MTFs) on various environmental and radar parameters during the Marine Remote Sensing experiment of 1979 (MARSEN 79). These MIF are presented, as are coherence functions between the AM and FM parts of the backscattered microwave signal. It is shown that they both depend on several of these parameters. Besides confirming many of the properties of transfer functions reported by previous authors, indications are found that MTFs decrease with increasing angle between wave propagation and antenna-look directions but are essentially independent of small changes in air-sea temperature difference. However, coherence functions are much smaller when the antennas are pointed perpendicular to long waves. It is found that X band transfer functions measured with horizontally polarized microwave radiation have larger magnitudes than those obtained by using vertical polarization.

  2. Effect on child cognitive function of increasing household expenditure in Indonesia: application of a marginal structural model and simulation of a cash transfer programme.

    PubMed

    Maika, Amelia; Mittinty, Murthy N; Brinkman, Sally; Lynch, John

    2015-02-01

    Parental investments in children are an important determinant of human capability formation. We investigated the causal effect of household expenditure on Indonesian children's cognitive function between 2000 and 2007. We also investigated the effect of change in mean cognitive function from a simulation of a hypothetical cash transfer intervention. A longitudinal analysis using data from the Indonesian Family Life Survey (IFLS) was conducted including 6136 children aged 7 to 14 years in 2000 and still alive in 2007. We used the inverse probability of treatment weighting of a marginal structural model to estimate the causal effect of household expenditure on children's cognitive function. Cumulative household expenditure was positively associated with cognitive function z-score. From the marginal structural model, a 74534 rupiah/month (about US$9) increase in household expenditure resulted in a 0.03 increase in cognitive function z-score [β=0.32, 95% confidence interval (CI) 0.30-0.35] Based on our simulations, among children in the poorest households in 2000 an additional ≈ US$6-10 of cash transfer resulted in a 0.01 unit increase in cognitive function z-score, equivalent to about 6% increase from the mean z-score prior to cash transfer. In contrast, children in the poorest household in 2007 did not benefit from an additional ≈ US$10 cash transfer. We found no overall effect of cash transfers at the total population level. Greater household expenditure had a small causal effect on children's cognitive function. Although cash transfer interventions had a positive effect for poor children, this effect was quite small. Multi-faceted interventions that combine nutrition, cash transfer, improved living conditions and women's education are required to benefit children's cognitive development in Indonesia. © The Author 2015; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.

  3. Explicit construction of quadratic Lyapunov functions for the small gain, positivity, circle, and Popov theorems and their application to robust stability

    NASA Technical Reports Server (NTRS)

    Haddad, Wassim M.; Bernstein, Dennis S.

    1991-01-01

    Lyapunov function proofs of sufficient conditions for asymptotic stability are given for feedback interconnections of bounded real and positive real transfer functions. Two cases are considered: (1) a proper bounded real (resp., positive real) transfer function with a bounded real (resp., positive real) time-varying memoryless nonlinearity; and (2) two strictly proper bounded real (resp., positive real) transfer functions. A similar treatment is given for the circle and Popov theorems. Application of these results to robust stability with time-varying bounded real, positive real, and sector-bounded uncertainty is discussed.

  4. Bipolar Latissimus Dorsi Transfer for Restoration of Pectoralis Major Function in Poland Syndrome.

    PubMed

    Buchanan, Patrick; Leyngold, Mark; Mast, Bruce A

    2016-01-01

    Poland syndrome typically presents as a unilateral congenital complete or partial absence of the pectoralis major muscle, variably with other associated anomalies. Reconstruction of the defect typically concentrates on aesthetic restoration with functional outcomes being unsuccessful or limited. We present an innovative means of true muscle transfer that provided functional benefit to increase upper extremity strength. A 16-year-old adolescent boy with Poland syndrome manifesting as left pectoralis major muscle agenesis wished to undergo functional reconstruction. He wanted to play on his high school football team, but could not meet the minimum weightlifting requirements. An ipsilateral latissimus dorsi muscle bipolar functional transfer was done with bone-anchored inset into the sternum and humerus so that muscle flexion would replace the absent pectoralis major. A progressive weight training program was then instituted postoperatively. At 9 months, a significant increase in left upper extremity strength was confirmed. The patient ultimately was able to surpass the weightlifting requirements for his high school football team, and joined the team. Our highlighted procedure restored functional outcome using both plastic surgical principles and orthopedic techniques for muscle and tendon repair: bipolar muscle transfer and load-bearing muscle inset. Heretofore, transfer of the latissimus for provision of pectoralis major function has not been reported. Functional reconstruction was possible due to stable, bipolar muscle transfer with load-bearing muscle attachments into cortical bone of the anterior sternum and anteromedial aspect of the humerus. The techniques described should be within the skill set of most plastic surgeons, so that functional restoration for those with Poland syndrome is possible and accessible.

  5. Statistical Time Series Models of Pilot Control with Applications to Instrument Discrimination

    NASA Technical Reports Server (NTRS)

    Altschul, R. E.; Nagel, P. M.; Oliver, F.

    1984-01-01

    A general description of the methodology used in obtaining the transfer function models and verification of model fidelity, frequency domain plots of the modeled transfer functions, numerical results obtained from an analysis of poles and zeroes obtained from z plane to s-plane conversions of the transfer functions, and the results of a study on the sequential introduction of other variables, both exogenous and endogenous into the loop are contained.

  6. Transfer Function Control for Biometric Monitoring System

    NASA Technical Reports Server (NTRS)

    Chmiel, Alan J. (Inventor); Grodinsky, Carlos M. (Inventor); Humphreys, Bradley T. (Inventor)

    2015-01-01

    A modular apparatus for acquiring biometric data may include circuitry operative to receive an input signal indicative of a biometric condition, the circuitry being configured to process the input signal according to a transfer function thereof and to provide a corresponding processed input signal. A controller is configured to provide at least one control signal to the circuitry to programmatically modify the transfer function of the modular system to facilitate acquisition of the biometric data.

  7. Graphic design of pinhole cameras

    NASA Technical Reports Server (NTRS)

    Edwards, H. B.; Chu, W. P.

    1979-01-01

    The paper describes a graphic technique for the analysis and optimization of pinhole size and focal length. The technique is based on the use of the transfer function of optical elements described by Scott (1959) to construct the transfer function of a circular pinhole camera. This transfer function is the response of a component or system to a pattern of lines having a sinusoidally varying radiance at varying spatial frequencies. Some specific examples of graphic design are presented.

  8. Derivation and application of the reciprocity relations for radiative transfer with internal illumination

    NASA Technical Reports Server (NTRS)

    Cogley, A. C.

    1975-01-01

    A Green's function formulation is used to derive basic reciprocity relations for planar radiative transfer in a general medium with internal illumination. Reciprocity (or functional symmetry) allows an explicit and generalized development of the equivalence between source and probability functions. Assuming similar symmetry in three-dimensional space, a general relationship is derived between planar-source intensity and point-source total directional energy. These quantities are expressed in terms of standard (universal) functions associated with the planar medium, while all results are derived from the differential equation of radiative transfer.

  9. Inhibition of the Autophagy Pathway Synergistically Potentiates the Cytotoxic Activity of Givinostat (ITF2357) on Human Glioblastoma Cancer Stem Cells.

    PubMed

    Angeletti, Francesca; Fossati, Gianluca; Pattarozzi, Alessandra; Würth, Roberto; Solari, Agnese; Daga, Antonio; Masiello, Irene; Barbieri, Federica; Florio, Tullio; Comincini, Sergio

    2016-01-01

    Increasing evidence highlighted the role of cancer stem cells (CSCs) in the development of tumor resistance to therapy, particularly in glioblastoma (GBM). Therefore, the development of new therapies, specifically directed against GBM CSCs, constitutes an important research avenue. Considering the extended range of cancer-related pathways modulated by histone acetylation/deacetylation processes, we studied the anti-proliferative and pro-apoptotic efficacy of givinostat (GVS), a pan-histone deacetylase inhibitor, on cell cultures enriched in CSCs, isolated from nine human GBMs. We report that GVS induced a significant reduction of viability and self-renewal ability in all GBM CSC cultures; conversely, GVS exposure did not cause a significant cytotoxic activity toward differentiated GBM cells and normal mesenchymal human stem cells. Analyzing the cellular and molecular mechanisms involved, we demonstrated that GVS affected CSC viability through the activation of programmed cell death pathways. In particular, a marked stimulation of macroautophagy was observed after GVS treatment. To understand the functional link between GVS treatment and autophagy activation, different genetic and pharmacological interfering strategies were used. We show that the up-regulation of the autophagy process, obtained by deprivation of growth factors, induced a reduction of CSC sensitivity to GVS, while the pharmacological inhibition of the autophagy pathway and the silencing of the key autophagy gene ATG7 , increased the cell death rate induced by GVS. Altogether these findings suggest that autophagy represents a pro-survival mechanism activated by GBM CSCs to counteract the efficacy of the anti-proliferative activity of GVS. In conclusion, we demonstrate that GVS is a novel pharmacological tool able to target GBM CSC viability and its efficacy can be enhanced by autophagy inhibitory strategies.

  10. Inhibition of the Autophagy Pathway Synergistically Potentiates the Cytotoxic Activity of Givinostat (ITF2357) on Human Glioblastoma Cancer Stem Cells

    PubMed Central

    Angeletti, Francesca; Fossati, Gianluca; Pattarozzi, Alessandra; Würth, Roberto; Solari, Agnese; Daga, Antonio; Masiello, Irene; Barbieri, Federica; Florio, Tullio; Comincini, Sergio

    2016-01-01

    Increasing evidence highlighted the role of cancer stem cells (CSCs) in the development of tumor resistance to therapy, particularly in glioblastoma (GBM). Therefore, the development of new therapies, specifically directed against GBM CSCs, constitutes an important research avenue. Considering the extended range of cancer-related pathways modulated by histone acetylation/deacetylation processes, we studied the anti-proliferative and pro-apoptotic efficacy of givinostat (GVS), a pan-histone deacetylase inhibitor, on cell cultures enriched in CSCs, isolated from nine human GBMs. We report that GVS induced a significant reduction of viability and self-renewal ability in all GBM CSC cultures; conversely, GVS exposure did not cause a significant cytotoxic activity toward differentiated GBM cells and normal mesenchymal human stem cells. Analyzing the cellular and molecular mechanisms involved, we demonstrated that GVS affected CSC viability through the activation of programmed cell death pathways. In particular, a marked stimulation of macroautophagy was observed after GVS treatment. To understand the functional link between GVS treatment and autophagy activation, different genetic and pharmacological interfering strategies were used. We show that the up-regulation of the autophagy process, obtained by deprivation of growth factors, induced a reduction of CSC sensitivity to GVS, while the pharmacological inhibition of the autophagy pathway and the silencing of the key autophagy gene ATG7, increased the cell death rate induced by GVS. Altogether these findings suggest that autophagy represents a pro-survival mechanism activated by GBM CSCs to counteract the efficacy of the anti-proliferative activity of GVS. In conclusion, we demonstrate that GVS is a novel pharmacological tool able to target GBM CSC viability and its efficacy can be enhanced by autophagy inhibitory strategies. PMID:27833530

  11. Revealed and stated preference valuation and transfer: A within-sample comparison of water quality improvement values

    NASA Astrophysics Data System (ADS)

    Ferrini, Silvia; Schaafsma, Marije; Bateman, Ian

    2014-06-01

    Benefit transfer (BT) methods are becoming increasingly important for environmental policy, but the empirical findings regarding transfer validity are mixed. A novel valuation survey was designed to obtain both stated preference (SP) and revealed preference (RP) data concerning river water quality values from a large sample of households. Both dichotomous choice and payment card contingent valuation (CV) and travel cost (TC) data were collected. Resulting valuations were directly compared and used for BT analyses using both unit value and function transfer approaches. WTP estimates are found to pass the convergence validity test. BT results show that the CV data produce lower transfer errors, below 20% for both unit value and function transfer, than TC data especially when using function transfer. Further, comparison of WTP estimates suggests that in all cases, differences between methods are larger than differences between study areas. Results show that when multiple studies are available, using welfare estimates from the same area but based on a different method consistently results in larger errors than transfers across space keeping the method constant.

  12. High Ulnar Nerve Injuries: Nerve Transfers to Restore Function.

    PubMed

    Patterson, Jennifer Megan M

    2016-05-01

    Peripheral nerve injuries are challenging problems. Nerve transfers are one of many options available to surgeons caring for these patients, although they do not replace tendon transfers, nerve graft, or primary repair in all patients. Distal nerve transfers for the treatment of high ulnar nerve injuries allow for a shorter reinnervation period and improved ulnar intrinsic recovery, which are critical to function of the hand. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Double Versus Single Tendon Transfers to Improve Shoulder Function in Brachial Plexus Birth Palsy.

    PubMed

    Greenhill, Dustin A; Smith, William R; Ramsey, F V; Kozin, Scott H; Zlotolow, Dan A

    2017-03-27

    In children with brachial plexus birth palsy (BPBP) undergoing tendon transfers to augment shoulder external rotation, it is unclear whether transfer of the latissimus dorsi with its combined latissimus dorsi and teres major (cLT) versus isolated teres major (iTM) tendon transfer yield different outcomes. Records of patients with BPBP who underwent shoulder tendon transfers to augment external rotation were retrospectively reviewed. Transfer type (cLT or iTM) was considered indiscriminate by virtue of surgeon preference. Modified Mallet Scale (mMS) and Active Movement Scale scores were recorded. Patients with <12 months' follow-up, C7 or lower palsy, humeral osteotomy, shoulder procedure(s) within 8 months, microsurgery within 1 year, or recurrent glenohumeral subluxation confirmed by postoperative imaging were excluded. Matched cohorts were identified within each tendon transfer group to yield similar preoperative shoulder function and glenohumeral alignment status. Outcomes for all tendon transfers as well as differences between cLT and iTM cohorts were analyzed. Among 121 cLT and 34 iTM transfers, 49 cLT and 14 iTM met the inclusion criteria. Subsequent matching of cohorts yielded 28 patients (14 cLT and 14 iTM). Average age at time of transfer was 3.0±1.4 years. Follow-up averaged 4.1±3.1 years. There were no statistically significant preoperative differences between cohorts, thus matching criteria were validated. Regardless of tendon(s) transferred, mMS external rotation improved (2.2 to 3.5, P<0.001), whereas mMS internal rotation decreased (3.8 to 3.2, P<0.001). When comparing matched cohorts, cLT transfer produced a greater mMS external rotation improvement than iTM (2.1 vs. 1.5, respectively; P=0.025). Loss of midline function (defined as mMS external rotation <3) occurred in 5 (35.7%) cLT and 2 (14.3%) iTM patients. Both cLT or iTM transfer are effective at augmenting shoulder external rotation in children with C5-C6 BPBP. Furthermore, cLT transfers may yield a larger improvement in external rotation in certain patients. However, both techniques slightly decrease shoulder internal rotation. Given that more total cLT patients lost midline function among matched cohorts, iTM transfer may still be considered when limited midline function is a concern. Level III.

  14. Significance of a Recurring Function in Energy Transfer

    ERIC Educational Resources Information Center

    Mishra, Subodha

    2017-01-01

    The appearance of a unique function in the energy transfer from one system to the other in different physical situations such as electrical, mechanical, optical, and quantum mechanical processes is established in this work. Though the laws governing the energy transformation and its transfer from system to system are well known, here we notice a…

  15. Three Essays on the Economics of Education

    ERIC Educational Resources Information Center

    Quin, Elizabeth

    2013-01-01

    Community colleges are a large part of the nation's higher education system and provide an important access point to post-secondary education for many students. Transfer to a four-year institution is one of the many functions served by community colleges. Despite the importance of the transfer function, the process of transferring between higher…

  16. Combined Henyey-Greenstein and Rayleigh phase function.

    PubMed

    Liu, Quanhua; Weng, Fuzhong

    2006-10-01

    The phase function is an important parameter that affects the distribution of scattered radiation. In Rayleigh scattering, a scatterer is approximated by a dipole, and its phase function is analytically related to the scattering angle. For the Henyey-Greenstein (HG) approximation, the phase function preserves only the correct asymmetry factor (i.e., the first moment), which is essentially important for anisotropic scattering. When the HG function is applied to small particles, it produces a significant error in radiance. In addition, the HG function is applied only for an intensity radiative transfer. We develop a combined HG and Rayleigh (HG-Rayleigh) phase function. The HG phase function plays the role of modulator extending the application of the Rayleigh phase function for small asymmetry scattering. The HG-Rayleigh phase function guarantees the correct asymmetry factor and is valid for a polarization radiative transfer. It approaches the Rayleigh phase function for small particles. Thus the HG-Rayleigh phase function has wider applications for both intensity and polarimetric radiative transfers. For microwave radiative transfer modeling in this study, the largest errors in the brightness temperature calculations for weak asymmetry scattering are generally below 0.02 K by using the HG-Rayleigh phase function. The errors can be much larger, in the 1-3 K range, if the Rayleigh and HG functions are applied separately.

  17. Direct metal transfer printing on flexible substrate for fabricating optics functional devices

    NASA Astrophysics Data System (ADS)

    Jiang, Yingjie; Zhou, Xiaohong; Zhang, Feng; Shi, Zhenwu; Chen, Linsen; Peng, Changsi

    2015-11-01

    New functional materials and devices based on metal patterns can be widely used in many new and expanding industries,such as flat panel displays, alternative energy,sensors and so on. In this paper, we introduce a new transfer printing method for fabricating metal optics functional devices. This method can directly transfer a metal pattern from a polyethylene terephthalate (PET)supported UV or polydimethylsiloxane (PDMS) pattern to another PET substrate. Purely taking advantage of the anaerobic UV curing adhesive (a-UV) on PET substrate, metal film can be easily peeled off from micro/nano-structured surface. As a result, metal film on the protrusion can be selectively transferred onto the target substrate, to make it the metal functional surface. But which on the bottom can not be transferred. This method provides low cost fabrication of metal thin film devices by avoiding high cost lithography process. Compared with conventional approach, this method can get more smooth rough edges and has wider tolerance range for the original master mold. Future developments and potential applications of this metal transfer method will be addressed.

  18. Effects of select and reject control on equivalence class formation and transfer of function.

    PubMed

    Perez, William F; Tomanari, Gerson Y; Vaidya, Manish

    2015-09-01

    The present study used a single-subject design to evaluate the effects of select or reject control on equivalence class formation and transfer of function. Adults were exposed to a matching-to-sample task with observing requirements (MTS-OR) in order to bias the establishment of sample/S+ (select) or sample/S- (reject) relations. In Experiment 1, four sets of baseline conditional relations were taught-two under reject control (A1B2C1, A2B1C2) and two under select control (D1E1F1, D2E2F2). Participants were tested for transitivity, symmetry, equivalence and reflexivity. They also learned a simple discrimination involving one of the stimuli from the equivalence classes and were tested for the transfer of the discriminative function. In general, participants performed with high accuracy on all equivalence-related probes as well as the transfer of function probes under select control. Under reject control, participants had high scores only on the symmetry test; transfer of function was attributed to stimuli programmed as S-. In Experiment 2, the equivalence class under reject control was expanded to four members (A1B2C1D2; A2B1C2D1). Participants had high scores only on symmetry and on transitivity and equivalence tests involving two nodes. Transfer of function was extended to the programmed S- added to each class. Results from both experiments suggest that select and reject controls might differently affect the formation of equivalence classes and the transfer of stimulus functions. © Society for the Experimental Analysis of Behavior.

  19. Active ankle dorsiflexion and the Mingazzini manoeuvre: two clinical bedside tests related to prognosis of postural transferring, standing and walking ability in patients with stroke.

    PubMed

    Smania, N; Gambarin, M; Paolucci, S; Girardi, P; Bortolami, M; Fiaschi, A; Santilli, V; Picelli, A

    2011-09-01

    Lower limb paresis is one of the main determinants of postural transferring, standing and walking disability in patients with stroke. Early prognosis of recovery of lower limb function and of related functional disability is an important issue in neurorehabilitation clinical practice. Aim of this study was to assess the relationship between active ankle dorsiflexion and the Mingazzini manoeuvre with the prognosis of lower limb function and of postural transferring, standing and walking ability in patients with stroke. This was a longitudinal study with prospectively collected data. University hospital. The study included 53 patients with first unilateral brain ischemic stroke. Patients were evaluated initially (mean 4.02 days) and approximately at six months (mean 178.6 days) after stroke. Initial assessment included active ankle dorsiflexion and the Mingazzini manoeuvre. The assessment after six months included three outcome measures evaluating the rate of improvement of lower limb function and of postural transferring, standing and walking ability (Postural Assessment Scale for Stroke patients, Functional Ambulation Category, Motricity Index leg subtest). The active ankle dorsiflexion showed to be related with the prognosis of lower limb function and of walking ability, while the Mingazzini manoeuvre was related with the improvement of postural transferring and standing ability. Active ankle dorsiflexion and the Mingazzini manoeuvre are related with the prognosis of lower limb function and of postural transferring, standing and walking ability in patients with stroke. These simple bedside tests give a picture of improvement potential of motor activities connected to lower limb function in patients with acute stroke.

  20. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Li, Yan-Rong; Wang, Jian-Min; Bai, Jin-Ming, E-mail: liyanrong@mail.ihep.ac.cn

    Broad emission lines of active galactic nuclei stem from a spatially extended region (broad-line region, BLR) that is composed of discrete clouds and photoionized by the central ionizing continuum. The temporal behaviors of these emission lines are blurred echoes of continuum variations (i.e., reverberation mapping, RM) and directly reflect the structures and kinematic information of BLRs through the so-called transfer function (also known as the velocity-delay map). Based on the previous works of Rybicki and Press and Zu et al., we develop an extended, non-parametric approach to determine the transfer function for RM data, in which the transfer function ismore » expressed as a sum of a family of relatively displaced Gaussian response functions. Therefore, arbitrary shapes of transfer functions associated with complicated BLR geometry can be seamlessly included, enabling us to relax the presumption of a specified transfer function frequently adopted in previous studies and to let it be determined by observation data. We formulate our approach in a previously well-established framework that incorporates the statistical modeling of continuum variations as a damped random walk process and takes into account long-term secular variations which are irrelevant to RM signals. The application to RM data shows the fidelity of our approach.« less

  1. Dynamic Stiffness Transfer Function of an Electromechanical Actuator Using System Identification

    NASA Astrophysics Data System (ADS)

    Kim, Sang Hwa; Tahk, Min-Jea

    2018-04-01

    In the aeroelastic analysis of flight vehicles with electromechanical actuators (EMAs), an accurate prediction of flutter requires dynamic stiffness characteristics of the EMA. The dynamic stiffness transfer function of the EMA with brushless direct current (BLDC) motor can be obtained by conducting complicated mathematical calculations of control algorithms and mechanical/electrical nonlinearities using linearization techniques. Thus, system identification approaches using experimental data, as an alternative, have considerable advantages. However, the test setup for system identification is expensive and complex, and experimental procedures for data collection are time-consuming tasks. To obtain the dynamic stiffness transfer function, this paper proposes a linear system identification method that uses information obtained from a reliable dynamic stiffness model with a control algorithm and nonlinearities. The results of this study show that the system identification procedure is compact, and the transfer function is able to describe the dynamic stiffness characteristics of the EMA. In addition, to verify the validity of the system identification method, the simulation results of the dynamic stiffness transfer function and the dynamic stiffness model were compared with the experimental data for various external loads.

  2. Excited State Charge Transfer reaction with dual emission from 5-(4-dimethylamino-phenyl)-penta-2,4-dienenitrile: Spectral measurement and theoretical density functional theory calculation

    NASA Astrophysics Data System (ADS)

    Jana, Sankar; Dalapati, Sasanka; Ghosh, Shalini; Kar, Samiran; Guchhait, Nikhil

    2011-07-01

    The excited state intramolecular charge transfer process in donor-chromophore-acceptor system 5-(4-dimethylamino-phenyl)-penta-2,4-dienenitrile (DMAPPDN) has been investigated by steady state absorption and emission spectroscopy in combination with Density Functional Theory (DFT) calculations. This flexible donor acceptor molecule DMAPPDN shows dual fluorescence corresponding to emission from locally excited and charge transfer state in polar solvent. Large solvatochromic emission shift, effect of variation of pH and HOMO-LUMO molecular orbital pictures support excited state intramolecular charge transfer process. The experimental findings have been correlated with the calculated structure and potential energy surfaces based on the Twisted Intramolecular Charge Transfer (TICT) model obtained at DFT level using B3LYP functional and 6-31+G( d, p) basis set. The theoretical potential energy surfaces for the excited states have been generated in vacuo and acetonitrile solvent using Time Dependent Density Functional Theory (TDDFT) and Time Dependent Density Functional Theory Polarized Continuum Model (TDDFT-PCM) method, respectively. All the theoretical results show well agreement with the experimental observations.

  3. Normalized power transmission between ABP and ICP in TBI.

    PubMed

    Shahsavari, S; Hallen, T; McKelvey, T; Ritzen, C; Rydenhag, B

    2009-01-01

    A new approach to study the pulse transmission between the cerebrovascular bed and the intracranial space is presented. In the proposed approach, the normalized power transmission between ABP and ICP has got the main attention rather than the actual power transmission. Evaluating the gain of the proposed transfer function at any single frequency can reveal how the percentage of contribution of that specific frequency component has been changed through the cerebrospinal system. The gain of the new transfer function at the fundamental cardiac frequency was utilized to evaluate the state of the brain in three TBI patients. Results were assessed using the reference evaluations achieved by a novel CT scan-based scoring scheme. In all three study cases, the gain of the transfer function showed a good capability to follow the trend of the CT scores and describe the brain state. Comparing the new transfer function with the traditional one and also the index of compensatory reserve, the proposed transfer function was found more informative about the state of the brain in the patients under study.

  4. The status of the SNS external antenna ion source and spare RFQ test facility

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Welton, R. F., E-mail: welton@ornl.gov; Aleksandrov, A. V.; Han, B. X.

    The Oak Ridge National Laboratory operates the Spallation Neutron Source, consisting of a H{sup −} ion source, a 1 GeV linac and an accumulator ring. The accumulated <1 μs-long, ∼35 A beam pulses are extracted from the ring at 60 Hz and directed onto a liquid Hg target. Spalled neutrons are directed to ∼20 world class instruments. Currently, the facility operates routinely with ∼1.2 MW of average beam power, which soon will be raised to 1.4 MW. A future upgrade with a second target station calls for raising the power to 2.8 MW. This paper describes the status of twomore » accelerator components expected to play important roles in achieving these goals: a recently acquired RFQ accelerator and the external antenna ion source. Currently, the RFQ is being conditioned in a newly constructed 2.5 MeV Integrated Test Facility (ITF) and the external antenna source is also being tested on a separate test stand. This paper presents the results of experiments and the testing of these systems.« less

  5. Importance of the ITF Junior Girls' Circuit in the development of women professional tennis players.

    PubMed

    Reid, Machar; Crespo, Miguel; Santilli, Luca

    2009-11-01

    In this study, we examined the extent to which ranking in professional women's tennis can be predicted by that in the top 20 International Tennis Federation's Junior Circuit. The names, nationalities, and birth dates of all players who achieved a top-20 girls' year-end ranking from 1995 to 2002 were recorded, with their progress through the professional ranks tracked to March 2008. Ninety-nine percent of top-20 ranked girls achieved a professional women's ranking. Stepwise regression analysis revealed peak junior ranking and the age at which that rank was achieved to be predictors of future professional ranking (r(2) = 0.133, P < 0.05). The following regression equation showed the achievement of a top-20 junior rank as a reasonable benchmark in the development of professional women players: log-transformed predicted professional rank = -0.552 + (0.032 x junior rank + 0.116 x age at junior rank). The predominant court surface on which junior players honed their skills was also implicated in professional ranking success, with clay-court play linked to the development of higher-ranked players (P < or = 0.01).

  6. A knowledge-based system design/information tool

    NASA Technical Reports Server (NTRS)

    Allen, James G.; Sikora, Scott E.

    1990-01-01

    The objective of this effort was to develop a Knowledge Capture System (KCS) for the Integrated Test Facility (ITF) at the Dryden Flight Research Facility (DFRF). The DFRF is a NASA Ames Research Center (ARC) facility. This system was used to capture the design and implementation information for NASA's high angle-of-attack research vehicle (HARV), a modified F/A-18A. In particular, the KCS was used to capture specific characteristics of the design of the HARV fly-by-wire (FBW) flight control system (FCS). The KCS utilizes artificial intelligence (AI) knowledge-based system (KBS) technology. The KCS enables the user to capture the following characteristics of automated systems: the system design; the hardware (H/W) design and implementation; the software (S/W) design and implementation; and the utilities (electrical and hydraulic) design and implementation. A generic version of the KCS was developed which can be used to capture the design information for any automated system. The deliverable items for this project consist of the prototype generic KCS and an application, which captures selected design characteristics of the HARV FCS.

  7. Dynamics driving function: new insights from electron transferring flavoproteins and partner complexes.

    PubMed

    Toogood, Helen S; Leys, David; Scrutton, Nigel S

    2007-11-01

    Electron transferring flavoproteins (ETFs) are soluble heterodimeric FAD-containing proteins that function primarily as soluble electron carriers between various flavoprotein dehydrogenases. ETF is positioned at a key metabolic branch point, responsible for transferring electrons from up to 10 primary dehydrogenases to the membrane-bound respiratory chain. Clinical mutations of ETF result in the often fatal disease glutaric aciduria type II. Structural and biophysical studies of ETF in complex with partner proteins have shown that ETF partitions the functions of partner binding and electron transfer between (a) a 'recognition loop', which acts as a static anchor at the ETF-partner interface, and (b) a highly mobile redox-active FAD domain. Together, this enables the FAD domain of ETF to sample a range of conformations, some compatible with fast interprotein electron transfer. This 'conformational sampling' enables ETF to recognize structurally distinct partners, whilst also maintaining a degree of specificity. Complex formation triggers mobility of the FAD domain, an 'induced disorder' mechanism contrasting with the more generally accepted models of protein-protein interaction by induced fit mechanisms. We discuss the implications of the highly dynamic nature of ETFs in biological interprotein electron transfer. ETF complexes point to mechanisms of electron transfer in which 'dynamics drive function', a feature that is probably widespread in biology given the modular assembly and flexible nature of biological electron transfer systems.

  8. The Simulation of Daily Temperature Time Series from GCM Output. Part II: Sensitivity Analysis of an Empirical Transfer Function Methodology.

    NASA Astrophysics Data System (ADS)

    Winkler, Julie A.; Palutikof, Jean P.; Andresen, Jeffrey A.; Goodess, Clare M.

    1997-10-01

    Empirical transfer functions have been proposed as a means for `downscaling' simulations from general circulation models (GCMs) to the local scale. However, subjective decisions made during the development of these functions may influence the ensuing climate scenarios. This research evaluated the sensitivity of a selected empirical transfer function methodology to 1) the definition of the seasons for which separate specification equations are derived, 2) adjustments for known departures of the GCM simulations of the predictor variables from observations, 3) the length of the calibration period, 4) the choice of function form, and 5) the choice of predictor variables. A modified version of the Climatological Projection by Model Statistics method was employed to generate control (1 × CO2) and perturbed (2 × CO2) scenarios of daily maximum and minimum temperature for two locations with diverse climates (Alcantarilla, Spain, and Eau Claire, Michigan). The GCM simulations used in the scenario development were from the Canadian Climate Centre second-generation model (CCC GCMII).Variations in the downscaling methodology were found to have a statistically significant impact on the 2 × CO2 climate scenarios, even though the 1 × CO2 scenarios for the different transfer function approaches were often similar. The daily temperature scenarios for Alcantarilla and Eau Claire were most sensitive to the decision to adjust for deficiencies in the GCM simulations, the choice of predictor variables, and the seasonal definitions used to derive the functions (i.e., fixed seasons, floating seasons, or no seasons). The scenarios were less sensitive to the choice of function form (i.e., linear versus nonlinear) and to an increase in the length of the calibration period.The results of Part I, which identified significant departures of the CCC GCMII simulations of two candidate predictor variables from observations, together with those presented here in Part II, 1) illustrate the importance of detailed comparisons of observed and GCM 1 × CO2 series of candidate predictor variables as an initial step in impact analysis, 2) demonstrate that decisions made when developing the transfer functions can have a substantial influence on the 2 × CO2 scenarios and their interpretation, 3) highlight the uncertainty in the appropriate criteria for evaluating transfer function approaches, and 4) suggest that automation of empirical transfer function methodologies is inappropriate because of differences in the performance of transfer functions between sites and because of spatial differences in the GCM's ability to adequately simulate the predictor variables used in the functions.

  9. Analysis and control of the METC fluid-bed gasifier. Quarterly report, October 1994--January 1995

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Farell, A.E.; Reddy, S.

    1995-03-01

    This document summarizes work performed for the period 10/1/94 to 2/1/95. The initial phase of the work focuses on developing a simple transfer function model of the Fluidized Bed Gasifier (FBG). This transfer function model will be developed based purely on the gasifier responses to step changes in gasifier inputs (including reactor air, convey air, cone nitrogen, FBG pressure, and coal feedrate). This transfer function model will represent a linear, dynamic model that is valid near the operating point at which the data was taken. In addition, a similar transfer function model will be developed using MGAS in order tomore » assess MGAS for use as a model of the FBG for control systems analysis.« less

  10. Effects of inclination and eccentricity on optimal trajectories between earth and Venus

    NASA Technical Reports Server (NTRS)

    Gravier, J.-P.; Marchal, C.; Culp, R. D.

    1973-01-01

    The true optimal transfers, including the effects of the inclination and eccentricity of the planets' orbits, between earth and Venus are presented as functions of the corresponding idealized Hohmann transfers. The method of determining the optimal transfers using the calculus of variations is presented. For every possible Hohmann window, specified as a continuous function of the longitude of perihelion of the Hohmann trajectory, the corresponding numerically exact optimal two-impulse transfers are given in graphical form. The cases for which the optimal two-impulse transfer is the absolute optimal, and those for which a three-impulse transfer provides the absolute optimal transfer are indicated. This information furnishes everything necessary for quick and accurate orbit calculations for preliminary Venus mission analysis. This makes it possible to use the actual optimal transfers for advanced planning in place of the standard Hohmann transfers.

  11. Regulatory RNAs derived from transfer RNA?

    PubMed

    Pederson, Thoru

    2010-10-01

    Four recent studies suggest that cleavages of transfer RNAs generate products with microRNA-like features, with some evidence of function. If their regulatory functions were to be confirmed, these newly revealed RNAs would add to the expanding repertoire of small noncoding RNAs and would also provide new perspectives on the coevolution of transfer RNA and messenger RNA.

  12. Pile transfer function

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Franz, J.P.

    The purpose of this memo is to present a detailed derivation of the transfer function of a critical pile and to relate this steady-state description and the transient response to a step function change of reactivity. Reference to G.E. report JIO-1 - Revised is implied throughout this discussion.

  13. Transfer Functions Via Laplace- And Fourier-Borel Transforms

    NASA Technical Reports Server (NTRS)

    Can, Sumer; Unal, Aynur

    1991-01-01

    Approach to solution of nonlinear ordinary differential equations involves transfer functions based on recently-introduced Laplace-Borel and Fourier-Borel transforms. Main theorem gives transform of response of nonlinear system as Cauchy product of transfer function and transform of input function of system, together with memory effects. Used to determine responses of electrical circuits containing variable inductances or resistances. Also possibility of doing all noncommutative algebra on computers in such symbolic programming languages as Macsyma, Reduce, PL1, or Lisp. Process of solution organized and possibly simplified by algebraic manipulations reducing integrals in solutions to known or tabulated forms.

  14. Automatic computation of transfer functions

    DOEpatents

    Atcitty, Stanley; Watson, Luke Dale

    2015-04-14

    Technologies pertaining to the automatic computation of transfer functions for a physical system are described herein. The physical system is one of an electrical system, a mechanical system, an electromechanical system, an electrochemical system, or an electromagnetic system. A netlist in the form of a matrix comprises data that is indicative of elements in the physical system, values for the elements in the physical system, and structure of the physical system. Transfer functions for the physical system are computed based upon the netlist.

  15. Application of 3-signal coherence to core noise transmission

    NASA Technical Reports Server (NTRS)

    Krejsa, E. A.

    1983-01-01

    A method for determining transfer functions across turbofan engine components and from the engine to the far-field is developed. The method is based on the three-signal coherence technique used previously to obtain far-field core noise levels. This method eliminates the bias error in transfer function measurements due to contamination of measured pressures by nonpropagating pressure fluctuations. Measured transfer functions from the engine to the far-field, across the tailpipe, and across the turbine are presented for three turbofan engines.

  16. Measurement and modeling of transfer functions for lightning coupling into the Sago mine.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Morris, Marvin E.; Higgins, Matthew B.

    2007-04-01

    This report documents measurements and analytical modeling of electromagnetic transfer functions to quantify the ability of cloud-to-ground lightning strokes (including horizontal arc-channel components) to couple electromagnetic energy into the Sago mine located near Buckhannon, WV. Two coupling mechanisms were measured: direct and indirect drive. These transfer functions are then used to predict electric fields within the mine and induced voltages on conductors that were left abandoned in the sealed area of the Sago mine.

  17. International transferability of accident modification functions for horizontal curves.

    PubMed

    Elvik, Rune

    2013-10-01

    Studies of the relationship between characteristics of horizontal curves and accident rate have been reported in several countries. The characteristic most often studied is the radius of a horizontal curve. Functions describing the relationship between the radius of horizontal curves and accident rate have been developed in Australia, Canada, Denmark, Germany, Great Britain, New Zealand, Norway, Portugal, Sweden, and the United States. Other characteristics of horizontal curves that have been studied include deflection angle, curve length, the presence of transition curves, super-elevation in curves and distance to adjacent curves. This paper assesses the international transferability of mathematical functions (accident modification functions) that have been developed to relate the radius of horizontal curves to their accident rate. The main research problem is whether these functions are similar, which enhances international transferability, or dissimilar, which reduces international transferability. Accident modification functions for horizontal curve radius developed in the countries listed above are synthesised. The sensitivity of the functions to other characteristics of curves than radius is examined. Accident modification functions developed in different countries have important similarities. The functions diverge with respect to accident rate in the sharpest curves. Copyright © 2013 Elsevier Ltd. All rights reserved.

  18. Synaptic convergence regulates synchronization-dependent spike transfer in feedforward neural networks.

    PubMed

    Sailamul, Pachaya; Jang, Jaeson; Paik, Se-Bum

    2017-12-01

    Correlated neural activities such as synchronizations can significantly alter the characteristics of spike transfer between neural layers. However, it is not clear how this synchronization-dependent spike transfer can be affected by the structure of convergent feedforward wiring. To address this question, we implemented computer simulations of model neural networks: a source and a target layer connected with different types of convergent wiring rules. In the Gaussian-Gaussian (GG) model, both the connection probability and the strength are given as Gaussian distribution as a function of spatial distance. In the Uniform-Constant (UC) and Uniform-Exponential (UE) models, the connection probability density is a uniform constant within a certain range, but the connection strength is set as a constant value or an exponentially decaying function, respectively. Then we examined how the spike transfer function is modulated under these conditions, while static or synchronized input patterns were introduced to simulate different levels of feedforward spike synchronization. We observed that the synchronization-dependent modulation of the transfer function appeared noticeably different for each convergence condition. The modulation of the spike transfer function was largest in the UC model, and smallest in the UE model. Our analysis showed that this difference was induced by the different spike weight distributions that was generated from convergent synapses in each model. Our results suggest that, the structure of the feedforward convergence is a crucial factor for correlation-dependent spike control, thus must be considered important to understand the mechanism of information transfer in the brain.

  19. Salvage of cervical motor radiculopathy using peripheral nerve transfer reconstruction.

    PubMed

    Afshari, Fardad T; Hossain, Taushaba; Miller, Caroline; Power, Dominic M

    2018-05-10

    Motor nerve transfer surgery involves re-innervation of important distal muscles using either an expendable motor branch or a fascicle from an adjacent functioning nerve. This technique is established as part of the reconstructive algorithm for traumatic brachial plexus injuries. The reproducible outcomes of motor nerve transfer surgery have resulted in exploration of the application of this technique to other paralysing conditions. The objective of this study is to report feasibility and increase awareness about nerve transfer as a method of improving upper limb function in patients with cervical motor radiculopathy of different aetiology. In this case series we report 3 cases with different modes of injury to the spinal nerve roots with significant and residual motor radiculopathy that have been successfully treated with nerve transfer surgery with good functional outcomes. The cases involved iatrogenic nerve root injury, tumour related root compression and degenerative root compression. Nerve transfer surgery may offer reliable reconstruction for paralysis when there has been no recovery following a period of conservative management. However the optimum timing of nerve transfer intervention is not yet identified for patients with motor radiculopathy.

  20. Two-Dimensional Magnetotelluric Modelling of Ore Deposits: Improvements in Model Constraints by Inclusion of Borehole Measurements

    NASA Astrophysics Data System (ADS)

    Kalscheuer, Thomas; Juhojuntti, Niklas; Vaittinen, Katri

    2017-12-01

    A combination of magnetotelluric (MT) measurements on the surface and in boreholes (without metal casing) can be expected to enhance resolution and reduce the ambiguity in models of electrical resistivity derived from MT surface measurements alone. In order to quantify potential improvement in inversion models and to aid design of electromagnetic (EM) borehole sensors, we considered two synthetic 2D models containing ore bodies down to 3000 m depth (the first with two dipping conductors in resistive crystalline host rock and the second with three mineralisation zones in a sedimentary succession exhibiting only moderate resistivity contrasts). We computed 2D inversion models from the forward responses based on combinations of surface impedance measurements and borehole measurements such as (1) skin-effect transfer functions relating horizontal magnetic fields at depth to those on the surface, (2) vertical magnetic transfer functions relating vertical magnetic fields at depth to horizontal magnetic fields on the surface and (3) vertical electric transfer functions relating vertical electric fields at depth to horizontal magnetic fields on the surface. Whereas skin-effect transfer functions are sensitive to the resistivity of the background medium and 2D anomalies, the vertical magnetic and electric field transfer functions have the disadvantage that they are comparatively insensitive to the resistivity of the layered background medium. This insensitivity introduces convergence problems in the inversion of data from structures with strong 2D resistivity contrasts. Hence, we adjusted the inversion approach to a three-step procedure, where (1) an initial inversion model is computed from surface impedance measurements, (2) this inversion model from surface impedances is used as the initial model for a joint inversion of surface impedances and skin-effect transfer functions and (3) the joint inversion model derived from the surface impedances and skin-effect transfer functions is used as the initial model for the inversion of the surface impedances, skin-effect transfer functions and vertical magnetic and electric transfer functions. For both synthetic examples, the inversion models resulting from surface and borehole measurements have higher similarity to the true models than models computed exclusively from surface measurements. However, the most prominent improvements were obtained for the first example, in which a deep small-sized ore body is more easily distinguished from a shallow main ore body penetrated by a borehole and the extent of the shadow zone (a conductive artefact) underneath the main conductor is strongly reduced. Formal model error and resolution analysis demonstrated that predominantly the skin-effect transfer functions improve model resolution at depth below the sensors and at distance of ˜ 300-1000 m laterally off a borehole, whereas the vertical electric and magnetic transfer functions improve resolution along the borehole and in its immediate vicinity. Furthermore, we studied the signal levels at depth and provided specifications of borehole magnetic and electric field sensors to be developed in a future project. Our results suggest that three-component SQUID and fluxgate magnetometers should be developed to facilitate borehole MT measurements at signal frequencies above and below 1 Hz, respectively.

  1. Is tibialis anterior tendon transfer effective for recurrent clubfoot?

    PubMed

    Gray, Kelly; Burns, Joshua; Little, David; Bellemore, Michael; Gibbons, Paul

    2014-02-01

    Tibialis anterior tendon transfer surgery forms a part of Ponseti management for children with congenital talipes equinovarus who, after initial correction, present with residual dynamic supination. Although retrospective studies support good outcomes, prospective longitudinal studies in this population are lacking. We assessed strength, plantar loading, ROM, foot alignment, function, satisfaction, and quality of life in patients with clubfoot that recurred after Ponseti casting who met indications for tibialis anterior tendon transfer surgery, and compared them with a group of patients with clubfoot treated with casting but whose deformity did not recur (therefore who were not indicated for tibialis anterior tendon transfer surgery). Twenty children with idiopathic congenital talipes equinovarus indicated for tibialis anterior tendon transfer surgery were recruited. Assessment at baseline (before surgery), and 3, 6, and 12 months (after surgery) included strength (hand-held dynamometry), plantar loading (capacitance transducer matrix platform), ROM (Dimeglio scale), foot alignment (Foot Posture Index(©)), function and satisfaction (disease-specific instrument for clubfoot), and quality of life (Infant Toddler Quality of Life Questionnaire™). Outcomes were compared with those of 12 age-matched children with congenital talipes equinovarus not indicated for tibialis anterior tendon transfer surgery. Followup was 100% in the control group and 95% (19 of 20) in the tibialis anterior transfer group. At baseline, the tibialis anterior tendon transfer group had a significantly worse eversion-to-inversion strength ratio, plantar loading, ROM, foot alignment, and function and satisfaction. At 3 months after surgery, eversion-to-inversion strength, plantar loading, and function and satisfaction were no longer different between groups. Improvements were maintained at 12 months after surgery (eversion-to-inversion strength mean difference, 8% body weight; 95% CI, -26% to 11%; p = 0.412; plantar loading, p > 0.251; function and satisfaction, p = 0.076). ROM remained less and foot alignment more supinated in the tibialis anterior tendon transfer group between baseline and followup (p < 0.001, p < 0.001). Tibialis anterior tendon transfer surgery was an effective procedure, which at 12-month followup restored the balance of eversion-to-inversion strength and resulted in plantar loading and function and satisfaction outcomes similar to those of age-matched children with congenital talipes equinovarus who after Ponseti casting were not indicated for tibialis anterior tendon transfer.

  2. Neurocognitive enhancement in older adults: comparison of three cognitive training tasks to test a hypothesis of training transfer in brain connectivity.

    PubMed

    Strenziok, Maren; Parasuraman, Raja; Clarke, Ellen; Cisler, Dean S; Thompson, James C; Greenwood, Pamela M

    2014-01-15

    The ultimate goal of cognitive enhancement as an intervention for age-related cognitive decline is transfer to everyday cognitive functioning. Development of training methods that transfer broadly to untrained cognitive tasks (far transfer) requires understanding of the neural bases of training and far transfer effects. We used cognitive training to test the hypothesis that far transfer is associated with altered attentional control demands mediated by the dorsal attention network and trained sensory cortex. In an exploratory study, we randomly assigned 42 healthy older adults to six weeks of training on Brain Fitness (BF-auditory perception), Space Fortress (SF-visuomotor/working memory), or Rise of Nations (RON-strategic reasoning). Before and after training, cognitive performance, diffusion-derived white matter integrity, and functional connectivity of the superior parietal cortex (SPC) were assessed. We found the strongest effects from BF training, which transferred to everyday problem solving and reasoning and selectively changed integrity of occipito-temporal white matter associated with improvement on untrained everyday problem solving. These results show that cognitive gain from auditory perception training depends on heightened white matter integrity in the ventral attention network. In BF and SF (which also transferred positively), a decrease in functional connectivity between SPC and inferior temporal lobe (ITL) was observed compared to RON-which did not transfer to untrained cognitive function. These findings highlight the importance for cognitive training of top-down control of sensory processing by the dorsal attention network. Altered brain connectivity - observed in the two training tasks that showed far transfer effects - may be a marker for training success. © 2013 Elsevier Inc. All rights reserved.

  3. Backward Transfer: An Investigation of the Influence of Quadratic Functions Instruction on Students' Prior Ways of Reasoning about Linear Functions

    ERIC Educational Resources Information Center

    Hohensee, Charles

    2014-01-01

    The transfer of learning has been the subject of much scientific inquiry in the social sciences. However, mathematics education research has given little attention to a subclass called backward transfer, which is when learning about new concepts influences learners' ways of reasoning about previously encountered concepts. This study examined when…

  4. The Mid-Term Changes of Pulmonary Function Tests After Phrenic Nerve Transfer.

    PubMed

    Yavari, Masoud; Hassanpour, Seyed Esmail; Khodayari, Mohammad

    2016-03-01

    In the restoration of elbow flexion, the phrenic nerve has proven to be a good donor, but considering the role of the phrenic nerve in respiratory function, we cannot disregard the potential dangers of this method. In the current study, we reviewed the results of pulmonary function tests (PFT) in four patients who underwent phrenic nerve transfer. We reviewed the results of serial spirometry tests, which were performed before and after phrenic nerve transfer surgery. All patients regained Biceps power to M3 strength or above. None of our patients experienced pulmonary problems or respiratory complaints, but a significant reduction of spirometric parameters occurred after surgery. This study highlights the close link between the role of the phrenic nerve and pulmonary function, such that the use of this nerve as a transfer donor leads to spirometric impairments.

  5. Centralized PI control for high dimensional multivariable systems based on equivalent transfer function.

    PubMed

    Luan, Xiaoli; Chen, Qiang; Liu, Fei

    2014-09-01

    This article presents a new scheme to design full matrix controller for high dimensional multivariable processes based on equivalent transfer function (ETF). Differing from existing ETF method, the proposed ETF is derived directly by exploiting the relationship between the equivalent closed-loop transfer function and the inverse of open-loop transfer function. Based on the obtained ETF, the full matrix controller is designed utilizing the existing PI tuning rules. The new proposed ETF model can more accurately represent the original processes. Furthermore, the full matrix centralized controller design method proposed in this paper is applicable to high dimensional multivariable systems with satisfactory performance. Comparison with other multivariable controllers shows that the designed ETF based controller is superior with respect to design-complexity and obtained performance. Copyright © 2014 ISA. Published by Elsevier Ltd. All rights reserved.

  6. The Use of Dispersion Relations For The Geomagnetic Transfer Functions

    NASA Astrophysics Data System (ADS)

    Marcuello, A.; Queralt, P.; Ledo, J. J.

    The magnetotelluric responses are complex magnitudes, where real and imaginary parts contain the same information on the geoelectrical structure. It seems possible, from very general hypotheses on the geoelectrical models (causality, stability and passivity), to apply the Kramers-Krönig dispersion relations to the magnetotelluric responses (impedance, geomagnetic transfer functions,...). In particular, the applica- bility of these relations to the impedance is a current point of discussion, but there are not many examples of their application to the geomagnetic transfer functions (tipper). The aim of this paper is to study how the relations of dispersion are applied to the real and imaginary part of the geomagnetic transfer functions, and to check its validity. For this reason, we have considered data (or responses) from two- and three-dimensional structures, and for these data, we have taken two situations: 1.- Responses that have been synthetically generated from numerical modelling, that allows us to control the quality of the data. 2.- Responses obtained from fieldwork, that are affected by exper- imental error. Additionally, we have also explored the use of these relations to extrap- olate the geomagnetic transfer functions outside the interval of measured frequencies, in order to obtain constrains on the values of these extrapolated data. The results have shown that the dispersion relations are accomplished for the geomag- netic transfer functions, and they can offer information about how these responses are behaved outside (but near) the range of measured frequencies.

  7. The transfer of Crel contextual control (same, opposite, less than, more than) through equivalence relations.

    PubMed

    Perez, William F; Kovac, Roberta; Nico, Yara C; Caro, Daniel M; Fidalgo, Adriana P; Linares, Ila; de Almeida, João Henrique; de Rose, Júlio C

    2017-11-01

    According to Relational Frame Theory (RFT) C rel denotes a contextual stimulus that controls a particular type of relational response (sameness, opposition, comparative, temporal, hierarchical etc.) in a given situation. Previous studies suggest that contextual functions may be indirectly acquired via transfer of function. The present study investigated the transfer of C rel contextual control through equivalence relations. Experiment 1 evaluated the transfer of C rel contextual functions for relational responses based on sameness and opposition. Experiment 2 extended these findings by evaluating transfer of function using comparative C rel stimuli. Both experiments followed a similar sequence of phases. First, abstract forms were established as C rel stimuli via multiple exemplar training (Phase 1). The contextual cues were then applied to establish arbitrary relations among nonsense words and to test derived relations (Phase 2). After that, equivalence relations involving the original C rel stimuli and other abstract forms were trained and tested (Phase 3). Transfer of function was evaluated by replacing the directly established C rel stimuli with their equivalent stimuli in the former experimental tasks (Phases 1 and 2). Results from both experiments suggest that C rel contextual control may be extended via equivalence relations, allowing other arbitrarily related stimuli to indirectly acquire C rel functions and regulate behavior by evoking appropriate relational responses in the presence of both previously known and novel stimuli. © 2017 Society for the Experimental Analysis of Behavior.

  8. Working memory training and transfer in older adults.

    PubMed

    Richmond, Lauren L; Morrison, Alexandra B; Chein, Jason M; Olson, Ingrid R

    2011-12-01

    There has been a great deal of interest, both privately and commercially, in using working memory training exercises to improve general cognitive function. However, many of the laboratory findings for older adults, a group in which this training is of utmost interest, are discouraging due to the lack of transfer to other tasks and skills. Importantly, improvements in everyday functioning remain largely unexamined in relation to WM training. We trained working memory in older adults using a task that encourages transfer in young adults (Chein & Morrison, 2010). We tested transfer to measures of working memory (e.g., Reading Span), everyday cognitive functioning [the Test of Everyday Attention (TEA) and the California Verbal Learning Test (CVLT)], and other tasks of interest. Relative to controls, trained participants showed transfer improvements in Reading Span and the number of repetitions on the CVLT. Training group participants were also significantly more likely to self-report improvements in everyday attention. Our findings support the use of ecological tasks as a measure of transfer in an older adult population.

  9. Direct repeat sequences are essential for function of the cis-acting locus of transfer (clt) of Streptomyces phaeochromogenes plasmid pJV1.

    PubMed

    Franco, Bernardo; González-Cerón, Gabriela; Servín-González, Luis

    2003-11-01

    The functionality of direct and inverted repeat sequences inside the cis acting locus of transfer (clt) of the Streptomyces plasmid pJV1 was determined by testing the effect of different deletions on plasmid transfer. The results show that the single most important element for pJV1 clt function is a series of evenly spaced 9 bp long direct repeats which match the consensus CCGCACA(C/G)(C/G), since their deletion caused a dramatic reduction in plasmid transfer. The presence of these repeats in the absence of any other clt sequences allowed plasmid transfer to occur at a frequency that was at least two orders of magnitude higher than that obtained in the complete absence of clt. A database search revealed regions with a similar organization, and in the same position, in Streptomyces plasmids pSN22 and pSLS, which have transfer proteins homologous to those of pJV1.

  10. Optical transfer function of NTS-1 retroreflector array

    NASA Technical Reports Server (NTRS)

    Arnold, D. A.

    1974-01-01

    An optical transfer function was computed for the retroreflector array carried by the NTS-1 satellite. Range corrections are presented for extrapolating laser range measurements to the center of mass of the satellite. The gain function of the array was computed for use in estimating laser-echo signal strengths.

  11. Curved Displacement Transfer Functions for Geometric Nonlinear Large Deformation Structure Shape Predictions

    NASA Technical Reports Server (NTRS)

    Ko, William L.; Fleischer, Van Tran; Lung, Shun-Fat

    2017-01-01

    For shape predictions of structures under large geometrically nonlinear deformations, Curved Displacement Transfer Functions were formulated based on a curved displacement, traced by a material point from the undeformed position to deformed position. The embedded beam (depth-wise cross section of a structure along a surface strain-sensing line) was discretized into multiple small domains, with domain junctures matching the strain-sensing stations. Thus, the surface strain distribution could be described with a piecewise linear or a piecewise nonlinear function. The discretization approach enabled piecewise integrations of the embedded-beam curvature equations to yield the Curved Displacement Transfer Functions, expressed in terms of embedded beam geometrical parameters and surface strains. By entering the surface strain data into the Displacement Transfer Functions, deflections along each embedded beam can be calculated at multiple points for mapping the overall structural deformed shapes. Finite-element linear and nonlinear analyses of a tapered cantilever tubular beam were performed to generate linear and nonlinear surface strains and the associated deflections to be used for validation. The shape prediction accuracies were then determined by comparing the theoretical deflections with the finiteelement- generated deflections. The results show that the newly developed Curved Displacement Transfer Functions are very accurate for shape predictions of structures under large geometrically nonlinear deformations.

  12. Motor and Sensory Cortical Changes after Contralateral Cervical Seventh Nerve Root (CC7) Transfer in Patients with Brachial Plexus Injuries.

    PubMed

    Kakinoki, Ryosuke; Duncan, Scott F M; Ikeguchi, Ryosuke; Ohta, Souichi; Nankaku, Manabu; Sakai, Hiroshi; Noguchi, Takashi; Kaizawa, Yukitoshi; Akagi, Masao

    2017-06-01

    Previous animal studies demonstrated that the sensory and motor functions in ipsilesional upper limbs that had been reconstructed by CC7 transfer eventually associated with the contralesional brain cortices that had originally mediated the functions of the ipsilesional upper limbs before brachial plexus injury (BPI). Our hypothesis was that the same findings would be seen in humans. Four patients with total BPI treated with CC7 transfer were included. Changes in the locations of the activated areas in the primary motor (M1) and somatosensory (S1) cortices corresponding to the motor outputs to and sensory inputs from the ipsilesional limbs were investigated using functional near-infrared spectroscopy (fNIRS) 2-3 years and 6-7 years after surgery. One patient was excluded from the evaluation of motor function after CC7 transfer. The motor and sensory functions of the ipsilesional upper limb in all patients were still controlled by the ipsilesional brain hemisphere 2-3 years after CC7 transfer. The reconstructed motions of the ipsilesional upper limbs correlated with the contralesional M1 in one patient and the bilateral M1s in another patient (both of whom demonstrated good motor recovery in the ipsilesional upper limbs) and with the ipsilesional M1 in a third patient with poor motor recovery in the ipsilesional upper limb. Sensory stimulation of the ipsilesional hands 6-7 years after CC7 transfer activated the contralesional S1 in two patients who achieved good sensory recovery in the ipsilesional hands but activated the ipsilesional S1 in the other two patients with poor sensory recovery of the ipsilesional hands. Transhemispheric transposition of the activated brain cortices associated with the recovery of motor and sensory functions of the ipsilesional upper limbs was seen in patients with CC7 transfer as has been reported for animal models of CC7 transfer.

  13. Estimation of Handling Qualities Parameters of the Tu-144 Supersonic Transport Aircraft from Flight Test Data

    NASA Technical Reports Server (NTRS)

    Curry, Timothy J.; Batterson, James G. (Technical Monitor)

    2000-01-01

    Low order equivalent system (LOES) models for the Tu-144 supersonic transport aircraft were identified from flight test data. The mathematical models were given in terms of transfer functions with a time delay by the military standard MIL-STD-1797A, "Flying Qualities of Piloted Aircraft," and the handling qualities were predicted from the estimated transfer function coefficients. The coefficients and the time delay in the transfer functions were estimated using a nonlinear equation error formulation in the frequency domain. Flight test data from pitch, roll, and yaw frequency sweeps at various flight conditions were used for parameter estimation. Flight test results are presented in terms of the estimated parameter values, their standard errors, and output fits in the time domain. Data from doublet maneuvers at the same flight conditions were used to assess the predictive capabilities of the identified models. The identified transfer function models fit the measured data well and demonstrated good prediction capabilities. The Tu-144 was predicted to be between level 2 and 3 for all longitudinal maneuvers and level I for all lateral maneuvers. High estimates of the equivalent time delay in the transfer function model caused the poor longitudinal rating.

  14. Analysis of space vehicle structures using the transfer-function concept

    NASA Technical Reports Server (NTRS)

    Heer, E.; Trubert, M. R.

    1969-01-01

    Analysis of large complex systems is accomplished by dividing it into suitable subsystems and determining the individual dynamical and vibrational responses. Frequency transfer functions then determine the vibrational response of the whole system.

  15. Estimating the transfer function of the cantilever in atomic force microscopy: A system identification approach

    NASA Astrophysics Data System (ADS)

    Stark, Martin; Guckenberger, Reinhard; Stemmer, Andreas; Stark, Robert W.

    2005-12-01

    Dynamic atomic force microscopy (AFM) offers many opportunities for the characterization and manipulation of matter on the nanometer scale with a high temporal resolution. The analysis of time-dependent forces is basic for a deeper understanding of phenomena such as friction, plastic deformation, and surface wetting. However, the dynamic characteristics of the force sensor used for such investigations are determined by various factors such as material and geometry of the cantilever, detection alignment, and the transfer characteristics of the detector. Thus, for a quantitative investigation of surface properties by dynamic AFM an appropriate system identification procedure is required, characterizing the force sensor beyond the usual parameters spring constant, quality factor, and detection sensitivity. Measurement of the transfer function provides such a characterization that fully accounts for the dynamic properties of the force sensor. Here, we demonstrate the estimation of the transfer function in a bandwidth of 1MHz from experimental data. To this end, we analyze the signal of the vibrations induced by snap-to-contact and snap-off-contact events. For the free cantilever, we determine both a parameter-free estimate [empirical transfer function estimate (ETFE)] and a parametric estimate of the transfer function. For the surface-coupled cantilever the ETFE is obtained. These identification procedures provide an intrinsic calibration as they dispense largely with a priori knowledge about the force sensor.

  16. A novel methodology for radiative transfer in a planetary atmosphere. I - The functions a exponent m and b exponent m of anisotropic scattering

    NASA Technical Reports Server (NTRS)

    Fymat, A. L.; Kalaba, R. E.

    1977-01-01

    The original problem of anisotropic scattering in an atmosphere illuminated by a unidirectional source is replaced by an analogous formulation where the incident light is omnidirectional. A radiative-transfer equation for the omnidirectional case is obtained in which the direction of illumination plays no role and the source-function analog, Sobolev's (1972) source function Phi exponent m, contains only a single integral term. For radiation incident on the top or the bottom of the atmosphere, this equation involves the functions b exponent m and h exponent m, respectively, with m corresponding to the order of the harmonic component of the scattered radiation field; these two functions are shown to be only one through some simple reciprocity relations. The transfer problem is then reformulated for the function a exponent m, in which case the source-function analog (Sobolev's function D exponent m) involves incident direction.

  17. Linear modeling of steady-state behavioral dynamics.

    PubMed Central

    Palya, William L; Walter, Donald; Kessel, Robert; Lucke, Robert

    2002-01-01

    The observed steady-state behavioral dynamics supported by unsignaled periods of reinforcement within repeating 2,000-s trials were modeled with a linear transfer function. These experiments employed improved schedule forms and analytical methods to improve the precision of the measured transfer function, compared to previous work. The refinements include both the use of multiple reinforcement periods that improve spectral coverage and averaging of independently determined transfer functions. A linear analysis was then used to predict behavior observed for three different test schedules. The fidelity of these predictions was determined. PMID:11831782

  18. Horizontal gene transfer of microbial cellulases into nematode genomes is associated with functional assimilation and gene turnover

    PubMed Central

    2011-01-01

    Background Natural acquisition of novel genes from other organisms by horizontal or lateral gene transfer is well established for microorganisms. There is now growing evidence that horizontal gene transfer also plays important roles in the evolution of eukaryotes. Genome-sequencing and EST projects of plant and animal associated nematodes such as Brugia, Meloidogyne, Bursaphelenchus and Pristionchus indicate horizontal gene transfer as a key adaptation towards parasitism and pathogenicity. However, little is known about the functional activity and evolutionary longevity of genes acquired by horizontal gene transfer and the mechanisms favoring such processes. Results We examine the transfer of cellulase genes to the free-living and beetle-associated nematode Pristionchus pacificus, for which detailed phylogenetic knowledge is available, to address predictions by evolutionary theory for successful gene transfer. We used transcriptomics in seven Pristionchus species and three other related diplogastrid nematodes with a well-defined phylogenetic framework to study the evolution of ancestral cellulase genes acquired by horizontal gene transfer. We performed intra-species, inter-species and inter-genic analysis by comparing the transcriptomes of these ten species and tested for cellulase activity in each species. Species with cellulase genes in their transcriptome always exhibited cellulase activity indicating functional integration into the host's genome and biology. The phylogenetic profile of cellulase genes was congruent with the species phylogeny demonstrating gene longevity. Cellulase genes show notable turnover with elevated birth and death rates. Comparison by sequencing of three selected cellulase genes in 24 natural isolates of Pristionchus pacificus suggests these high evolutionary dynamics to be associated with copy number variations and positive selection. Conclusion We could demonstrate functional integration of acquired cellulase genes into the nematode's biology as predicted by theory. Thus, functional assimilation, remarkable gene turnover and selection might represent key features of horizontal gene transfer events in nematodes. PMID:21232122

  19. Horizontal gene transfer of microbial cellulases into nematode genomes is associated with functional assimilation and gene turnover.

    PubMed

    Mayer, Werner E; Schuster, Lisa N; Bartelmes, Gabi; Dieterich, Christoph; Sommer, Ralf J

    2011-01-13

    Natural acquisition of novel genes from other organisms by horizontal or lateral gene transfer is well established for microorganisms. There is now growing evidence that horizontal gene transfer also plays important roles in the evolution of eukaryotes. Genome-sequencing and EST projects of plant and animal associated nematodes such as Brugia, Meloidogyne, Bursaphelenchus and Pristionchus indicate horizontal gene transfer as a key adaptation towards parasitism and pathogenicity. However, little is known about the functional activity and evolutionary longevity of genes acquired by horizontal gene transfer and the mechanisms favoring such processes. We examine the transfer of cellulase genes to the free-living and beetle-associated nematode Pristionchus pacificus, for which detailed phylogenetic knowledge is available, to address predictions by evolutionary theory for successful gene transfer. We used transcriptomics in seven Pristionchus species and three other related diplogastrid nematodes with a well-defined phylogenetic framework to study the evolution of ancestral cellulase genes acquired by horizontal gene transfer. We performed intra-species, inter-species and inter-genic analysis by comparing the transcriptomes of these ten species and tested for cellulase activity in each species. Species with cellulase genes in their transcriptome always exhibited cellulase activity indicating functional integration into the host's genome and biology. The phylogenetic profile of cellulase genes was congruent with the species phylogeny demonstrating gene longevity. Cellulase genes show notable turnover with elevated birth and death rates. Comparison by sequencing of three selected cellulase genes in 24 natural isolates of Pristionchus pacificus suggests these high evolutionary dynamics to be associated with copy number variations and positive selection. We could demonstrate functional integration of acquired cellulase genes into the nematode's biology as predicted by theory. Thus, functional assimilation, remarkable gene turnover and selection might represent key features of horizontal gene transfer events in nematodes.

  20. Complementary Strategies for Directed C(sp3 )-H Functionalization: A Comparison of Transition-Metal-Catalyzed Activation, Hydrogen Atom Transfer, and Carbene/Nitrene Transfer.

    PubMed

    Chu, John C K; Rovis, Tomislav

    2018-01-02

    The functionalization of C(sp 3 )-H bonds streamlines chemical synthesis by allowing the use of simple molecules and providing novel synthetic disconnections. Intensive recent efforts in the development of new reactions based on C-H functionalization have led to its wider adoption across a range of research areas. This Review discusses the strengths and weaknesses of three main approaches: transition-metal-catalyzed C-H activation, 1,n-hydrogen atom transfer, and transition-metal-catalyzed carbene/nitrene transfer, for the directed functionalization of unactivated C(sp 3 )-H bonds. For each strategy, the scope, the reactivity of different C-H bonds, the position of the reacting C-H bonds relative to the directing group, and stereochemical outcomes are illustrated with examples in the literature. The aim of this Review is to provide guidance for the use of C-H functionalization reactions and inspire future research in this area. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Contextual Control by Function and Form of Transfer of Functions

    ERIC Educational Resources Information Center

    Perkins, David R.; Dougher, Michael J.; Greenway, David E.

    2007-01-01

    This study investigated conditions leading to contextual control by stimulus topography over transfer of functions. Three 4-member stimulus equivalence classes, each consisting of four (A, B, C, D) topographically distinct visual stimuli, were established for 5 college students. Across classes, designated A stimuli were open-ended linear figures,…

  2. Optical transfer function of Starlette retroreflector array

    NASA Technical Reports Server (NTRS)

    Arnold, D. A.

    1975-01-01

    An optical transfer function was computed for the retroreflector array carried by the Starlette satellite (1975 10A). The range correction is given for extrapolating laser range measurements to the center of mass of the satellite. The gain function and active reflecting area of the array are computed for estimating laser-echo signal strengths.

  3. OrbView-3 Technical Performance Evaluation 2005: Modulation Transfer Function

    NASA Technical Reports Server (NTRS)

    Cole, Aaron

    2007-01-01

    The Technical performance evaluation of OrbView-3 using the Modulation Transfer Function (MTF) is presented. The contents include: 1) MTF Results and Methodology; 2) Radiometric Calibration Methodology; and 3) Relative Radiometric Assessment Results

  4. Seeking maximum linearity of transfer functions

    NASA Astrophysics Data System (ADS)

    Silva, Filipi N.; Comin, Cesar H.; Costa, Luciano da F.

    2016-12-01

    Linearity is an important and frequently sought property in electronics and instrumentation. Here, we report a method capable of, given a transfer function (theoretical or derived from some real system), identifying the respective most linear region of operation with a fixed width. This methodology, which is based on least squares regression and systematic consideration of all possible regions, has been illustrated with respect to both an analytical (sigmoid transfer function) and a simple situation involving experimental data of a low-power, one-stage class A transistor current amplifier. Such an approach, which has been addressed in terms of transfer functions derived from experimentally obtained characteristic surface, also yielded contributions such as the estimation of local constants of the device, as opposed to typically considered average values. The reported method and results pave the way to several further applications in other types of devices and systems, intelligent control operation, and other areas such as identifying regions of power law behavior.

  5. Significance testing testate amoeba water table reconstructions

    NASA Astrophysics Data System (ADS)

    Payne, Richard J.; Babeshko, Kirill V.; van Bellen, Simon; Blackford, Jeffrey J.; Booth, Robert K.; Charman, Dan J.; Ellershaw, Megan R.; Gilbert, Daniel; Hughes, Paul D. M.; Jassey, Vincent E. J.; Lamentowicz, Łukasz; Lamentowicz, Mariusz; Malysheva, Elena A.; Mauquoy, Dmitri; Mazei, Yuri; Mitchell, Edward A. D.; Swindles, Graeme T.; Tsyganov, Andrey N.; Turner, T. Edward; Telford, Richard J.

    2016-04-01

    Transfer functions are valuable tools in palaeoecology, but their output may not always be meaningful. A recently-developed statistical test ('randomTF') offers the potential to distinguish among reconstructions which are more likely to be useful, and those less so. We applied this test to a large number of reconstructions of peatland water table depth based on testate amoebae. Contrary to our expectations, a substantial majority (25 of 30) of these reconstructions gave non-significant results (P > 0.05). The underlying reasons for this outcome are unclear. We found no significant correlation between randomTF P-value and transfer function performance, the properties of the training set and reconstruction, or measures of transfer function fit. These results give cause for concern but we believe it would be extremely premature to discount the results of non-significant reconstructions. We stress the need for more critical assessment of transfer function output, replication of results and ecologically-informed interpretation of palaeoecological data.

  6. Rapid electron transfer by the carbon matrix in natural pyrogenic carbon

    PubMed Central

    Sun, Tianran; Levin, Barnaby D. A.; Guzman, Juan J. L.; Enders, Akio; Muller, David A.; Angenent, Largus T.; Lehmann, Johannes

    2017-01-01

    Surface functional groups constitute major electroactive components in pyrogenic carbon. However, the electrochemical properties of pyrogenic carbon matrices and the kinetic preference of functional groups or carbon matrices for electron transfer remain unknown. Here we show that environmentally relevant pyrogenic carbon with average H/C and O/C ratios of less than 0.35 and 0.09 can directly transfer electrons more than three times faster than the charging and discharging cycles of surface functional groups and have a 1.5 V potential range for biogeochemical reactions that invoke electron transfer processes. Surface functional groups contribute to the overall electron flux of pyrogenic carbon to a lesser extent with greater pyrolysis temperature due to lower charging and discharging capacities, although the charging and discharging kinetics remain unchanged. This study could spur the development of a new generation of biogeochemical electron flux models that focus on the bacteria–carbon–mineral conductive network. PMID:28361882

  7. Electronic Coupling Calculations for Bridge-Mediated Charge Transfer Using Constrained Density Functional Theory (CDFT) and Effective Hamiltonian Approaches at the Density Functional Theory (DFT) and Fragment-Orbital Density Functional Tight Binding (FODFTB) Level

    DOE PAGES

    Gillet, Natacha; Berstis, Laura; Wu, Xiaojing; ...

    2016-09-09

    In this paper, four methods to calculate charge transfer integrals in the context of bridge-mediated electron transfer are tested. These methods are based on density functional theory (DFT). We consider two perturbative Green's function effective Hamiltonian methods (first, at the DFT level of theory, using localized molecular orbitals; second, applying a tight-binding DFT approach, using fragment orbitals) and two constrained DFT implementations with either plane-wave or local basis sets. To assess the performance of the methods for through-bond (TB)-dominated or through-space (TS)-dominated transfer, different sets of molecules are considered. For through-bond electron transfer (ET), several molecules that were originally synthesizedmore » by Paddon-Row and co-workers for the deduction of electronic coupling values from photoemission and electron transmission spectroscopies, are analyzed. The tested methodologies prove to be successful in reproducing experimental data, the exponential distance decay constant and the superbridge effects arising from interference among ET pathways. For through-space ET, dedicated p-stacked systems with heterocyclopentadiene molecules were created and analyzed on the basis of electronic coupling dependence on donor-acceptor distance, structure of the bridge, and ET barrier height. The inexpensive fragment-orbital density functional tight binding (FODFTB) method gives similar results to constrained density functional theory (CDFT) and both reproduce the expected exponential decay of the coupling with donor-acceptor distances and the number of bridging units. Finally, these four approaches appear to give reliable results for both TB and TS ET and present a good alternative to expensive ab initio methodologies for large systems involving long-range charge transfers.« less

  8. Electronic Coupling Calculations for Bridge-Mediated Charge Transfer Using Constrained Density Functional Theory (CDFT) and Effective Hamiltonian Approaches at the Density Functional Theory (DFT) and Fragment-Orbital Density Functional Tight Binding (FODFTB) Level

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gillet, Natacha; Berstis, Laura; Wu, Xiaojing

    In this paper, four methods to calculate charge transfer integrals in the context of bridge-mediated electron transfer are tested. These methods are based on density functional theory (DFT). We consider two perturbative Green's function effective Hamiltonian methods (first, at the DFT level of theory, using localized molecular orbitals; second, applying a tight-binding DFT approach, using fragment orbitals) and two constrained DFT implementations with either plane-wave or local basis sets. To assess the performance of the methods for through-bond (TB)-dominated or through-space (TS)-dominated transfer, different sets of molecules are considered. For through-bond electron transfer (ET), several molecules that were originally synthesizedmore » by Paddon-Row and co-workers for the deduction of electronic coupling values from photoemission and electron transmission spectroscopies, are analyzed. The tested methodologies prove to be successful in reproducing experimental data, the exponential distance decay constant and the superbridge effects arising from interference among ET pathways. For through-space ET, dedicated p-stacked systems with heterocyclopentadiene molecules were created and analyzed on the basis of electronic coupling dependence on donor-acceptor distance, structure of the bridge, and ET barrier height. The inexpensive fragment-orbital density functional tight binding (FODFTB) method gives similar results to constrained density functional theory (CDFT) and both reproduce the expected exponential decay of the coupling with donor-acceptor distances and the number of bridging units. Finally, these four approaches appear to give reliable results for both TB and TS ET and present a good alternative to expensive ab initio methodologies for large systems involving long-range charge transfers.« less

  9. Dynamics of networks of excitatory and inhibitory neurons in response to time-dependent inputs.

    PubMed

    Ledoux, Erwan; Brunel, Nicolas

    2011-01-01

    We investigate the dynamics of recurrent networks of excitatory (E) and inhibitory (I) neurons in the presence of time-dependent inputs. The dynamics is characterized by the network dynamical transfer function, i.e., how the population firing rate is modulated by sinusoidal inputs at arbitrary frequencies. Two types of networks are studied and compared: (i) a Wilson-Cowan type firing rate model; and (ii) a fully connected network of leaky integrate-and-fire (LIF) neurons, in a strong noise regime. We first characterize the region of stability of the "asynchronous state" (a state in which population activity is constant in time when external inputs are constant) in the space of parameters characterizing the connectivity of the network. We then systematically characterize the qualitative behaviors of the dynamical transfer function, as a function of the connectivity. We find that the transfer function can be either low-pass, or with a single or double resonance, depending on the connection strengths and synaptic time constants. Resonances appear when the system is close to Hopf bifurcations, that can be induced by two separate mechanisms: the I-I connectivity and the E-I connectivity. Double resonances can appear when excitatory delays are larger than inhibitory delays, due to the fact that two distinct instabilities exist with a finite gap between the corresponding frequencies. In networks of LIF neurons, changes in external inputs and external noise are shown to be able to change qualitatively the network transfer function. Firing rate models are shown to exhibit the same diversity of transfer functions as the LIF network, provided delays are present. They can also exhibit input-dependent changes of the transfer function, provided a suitable static non-linearity is incorporated.

  10. Restoration of Elbow Flexion in Patients With Complete Traumatic and Obstetric Brachial Plexus Injury After Functional Free Gracilis Muscle Transfer: Our Experience and Management.

    PubMed

    Nath, Rahul K; Boutros, Sean G; Somasundaram, Chandra

    2017-01-01

    Background: Functional free gracilis muscle transfer is an operative procedure for elbow reconstruction in patients with complete brachial plexus nerve and avulsion injuries and in delayed or prolonged nerve denervation, as well as in patients with inadequate upper extremity function after primary nerve reconstruction. Methods: We retrospectively reviewed our patient records and identified 24 patients with complete brachial plexus nerve injury (13 obstetric, 11 males and 2 females; 11 traumatic, 9 males and 2 females) whose affected arm and shoulder were totally paralyzed and their voluntary elbow flexion or the biceps function was poor preoperatively (mean M0-1/5 in MRC grade). These patients had undergone the functional free gracilis muscle transfer procedure at our clinic since 2005. Results: Ninety-two percent of all patients showed recovery and improvement. Successful free gracilis muscle transfer is defined as antigravity biceps muscle strength of M3-4/5 and higher, which was observed in 16 (8 obstetric and 8 traumatic) of our 24 patients (67%) in this study at least 1 year after functional free gracilis muscle transfer. This is statistically significant ( P < .000001) in comparison with their mean preoperative score (M0-1/5). There was no improvement in motor level of the biceps muscle (M0/5) in 2 patients (1 from each group). The donor site of these 24 patients showed no deficit in motor and sensory functions. Conclusions: Taken together, a significant number (92%) of patients in both obstetric and traumatic brachial plexus injury groups had recovery and improvement and most of these patients (64%) achieved antigravity and elbow flexion at least 1 year after free gracilis muscle transfer at our clinic.

  11. Restoration of Elbow Flexion in Patients With Complete Traumatic and Obstetric Brachial Plexus Injury After Functional Free Gracilis Muscle Transfer: Our Experience and Management

    PubMed Central

    Boutros, Sean G.; Somasundaram, Chandra

    2017-01-01

    Background: Functional free gracilis muscle transfer is an operative procedure for elbow reconstruction in patients with complete brachial plexus nerve and avulsion injuries and in delayed or prolonged nerve denervation, as well as in patients with inadequate upper extremity function after primary nerve reconstruction. Methods: We retrospectively reviewed our patient records and identified 24 patients with complete brachial plexus nerve injury (13 obstetric, 11 males and 2 females; 11 traumatic, 9 males and 2 females) whose affected arm and shoulder were totally paralyzed and their voluntary elbow flexion or the biceps function was poor preoperatively (mean M0-1/5 in MRC grade). These patients had undergone the functional free gracilis muscle transfer procedure at our clinic since 2005. Results: Ninety-two percent of all patients showed recovery and improvement. Successful free gracilis muscle transfer is defined as antigravity biceps muscle strength of M3-4/5 and higher, which was observed in 16 (8 obstetric and 8 traumatic) of our 24 patients (67%) in this study at least 1 year after functional free gracilis muscle transfer. This is statistically significant (P < .000001) in comparison with their mean preoperative score (M0-1/5). There was no improvement in motor level of the biceps muscle (M0/5) in 2 patients (1 from each group). The donor site of these 24 patients showed no deficit in motor and sensory functions. Conclusions: Taken together, a significant number (92%) of patients in both obstetric and traumatic brachial plexus injury groups had recovery and improvement and most of these patients (64%) achieved antigravity and elbow flexion at least 1 year after free gracilis muscle transfer at our clinic. PMID:29213347

  12. Electronic Coupling Calculations for Bridge-Mediated Charge Transfer Using Constrained Density Functional Theory (CDFT) and Effective Hamiltonian Approaches at the Density Functional Theory (DFT) and Fragment-Orbital Density Functional Tight Binding (FODFTB) Level.

    PubMed

    Gillet, Natacha; Berstis, Laura; Wu, Xiaojing; Gajdos, Fruzsina; Heck, Alexander; de la Lande, Aurélien; Blumberger, Jochen; Elstner, Marcus

    2016-10-11

    In this article, four methods to calculate charge transfer integrals in the context of bridge-mediated electron transfer are tested. These methods are based on density functional theory (DFT). We consider two perturbative Green's function effective Hamiltonian methods (first, at the DFT level of theory, using localized molecular orbitals; second, applying a tight-binding DFT approach, using fragment orbitals) and two constrained DFT implementations with either plane-wave or local basis sets. To assess the performance of the methods for through-bond (TB)-dominated or through-space (TS)-dominated transfer, different sets of molecules are considered. For through-bond electron transfer (ET), several molecules that were originally synthesized by Paddon-Row and co-workers for the deduction of electronic coupling values from photoemission and electron transmission spectroscopies, are analyzed. The tested methodologies prove to be successful in reproducing experimental data, the exponential distance decay constant and the superbridge effects arising from interference among ET pathways. For through-space ET, dedicated π-stacked systems with heterocyclopentadiene molecules were created and analyzed on the basis of electronic coupling dependence on donor-acceptor distance, structure of the bridge, and ET barrier height. The inexpensive fragment-orbital density functional tight binding (FODFTB) method gives similar results to constrained density functional theory (CDFT) and both reproduce the expected exponential decay of the coupling with donor-acceptor distances and the number of bridging units. These four approaches appear to give reliable results for both TB and TS ET and present a good alternative to expensive ab initio methodologies for large systems involving long-range charge transfers.

  13. Novel Model of Somatosensory Nerve Transfer in the Rat.

    PubMed

    Paskal, Adriana M; Paskal, Wiktor; Pelka, Kacper; Podobinska, Martyna; Andrychowski, Jaroslaw; Wlodarski, Pawel K

    2018-05-09

    Nerve transfer (neurotization) is a reconstructive procedure in which the distal denervated nerve is joined with a proximal healthy nerve of a less significant function. Neurotization models described to date are limited to avulsed roots or pure motor nerve transfers, neglecting the clinically significant mixed nerve transfer. Our aim was to determine whether femoral-to-sciatic nerve transfer could be a feasible model of mixed nerve transfer. Three Sprague Dawley rats were subjected to unilateral femoral-to-sciatic nerve transfer. After 50 days, functional recovery was evaluated with a prick test. At the same time, axonal tracers were injected into each sciatic nerve distally to the lesion site, to determine nerve fibers' regeneration. In the prick test, the rats retracted their hind limbs after stimulation, although the reaction was moderately weaker on the operated side. Seven days after injection of axonal tracers, dyes were visualized by confocal microscopy in the spinal cord. Innervation of the recipient nerve originated from higher segments of the spinal cord than that on the untreated side. The results imply that the femoral nerve axons, ingrown into the damaged sciatic nerve, reinnervate distal targets with a functional outcome.

  14. End-Functionalized Palladium SCS Pincer Polymers via Controlled Radical Polymerizations.

    PubMed

    Lye, Diane S; Cohen, Aaron E; Wong, Madeleine Z; Weck, Marcus

    2017-07-01

    A direct and facile route toward semitelechelic polymers, end-functionalized with palladated sulfur-carbon-sulfur pincer (Pd II -pincer) complexes is reported that avoids any post-polymerization step. Key to our methodology is the combination of reversible addition-fragmentation chain-transfer (RAFT) polymerization with functionalized chain-transfer agents. This strategy yields Pd end-group-functionalized materials with monomodal molar mass dispersities (Đ) of 1.18-1.44. The RAFT polymerization is investigated using a Pd II -pincer chain-transfer agent for three classes of monomers: styrene, tert-butyl acrylate, and N-isopropylacrylamide. The ensuing Pd II -pincer end-functionalized polymers are analyzed using 1 H NMR spectroscopy, gel-permeation chromatography, and elemental analysis. The RAFT polymerization methodology provides a direct pathway for the fabrication of Pd II -pincer functionalized polymers with complete end-group functionalization. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. 75 FR 13146 - Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-18

    ... Office of Management and Budget for extension and approval. Rule 17Ad-10 requires registered transfer... for which it performs transfer agent functions, including the purchase, transfer and redemptions of securities. In addition, the rule also requires transfer agents that maintain securityholder records to...

  16. Policy Transfer via Markov Logic Networks

    NASA Astrophysics Data System (ADS)

    Torrey, Lisa; Shavlik, Jude

    We propose using a statistical-relational model, the Markov Logic Network, for knowledge transfer in reinforcement learning. Our goal is to extract relational knowledge from a source task and use it to speed up learning in a related target task. We show that Markov Logic Networks are effective models for capturing both source-task Q-functions and source-task policies. We apply them via demonstration, which involves using them for decision making in an initial stage of the target task before continuing to learn. Through experiments in the RoboCup simulated-soccer domain, we show that transfer via Markov Logic Networks can significantly improve early performance in complex tasks, and that transferring policies is more effective than transferring Q-functions.

  17. Modeling Current Transfer from PV Modules Based on Meteorological Data

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hacke, Peter; Smith, Ryan; Kurtz, Sarah

    2016-11-21

    Current transferred from the active cell circuit to ground in modules undergoing potential-induced degradation (PID) stress is analyzed with respect to meteorological data. Duration and coulombs transferred as a function of whether the module is wet (from dew or rain) or the extent of uncondensed surface humidity are quantified based on meteorological indicators. With this, functions predicting the mode and rate of coulomb transfer are developed for use in estimating the relative PID stress associated with temperature, moisture, and system voltage in any climate. Current transfer in a framed crystalline silicon module is relatively high when there is no condensedmore » water on the module, whereas current transfer in a thin-film module held by edge clips is not, and displays a greater fraction of coulombs transferred when wet compared to the framed module in the natural environment.« less

  18. Use of localized performance-based functions for the specification and correction of hybrid imaging systems

    NASA Astrophysics Data System (ADS)

    Lisson, Jerold B.; Mounts, Darryl I.; Fehniger, Michael J.

    1992-08-01

    Localized wavefront performance analysis (LWPA) is a system that allows the full utilization of the system optical transfer function (OTF) for the specification and acceptance of hybrid imaging systems. We show that LWPA dictates the correction of wavefront errors with the greatest impact on critical imaging spatial frequencies. This is accomplished by the generation of an imaging performance map-analogous to a map of the optic pupil error-using a local OTF. The resulting performance map a function of transfer function spatial frequency is directly relatable to the primary viewing condition of the end-user. In addition to optimizing quality for the viewer it will be seen that the system has the potential for an improved matching of the optical and electronic bandpass of the imager and for the development of more realistic acceptance specifications. 1. LOCAL WAVEFRONT PERFORMANCE ANALYSIS The LWPA system generates a local optical quality factor (LOQF) in the form of a map analogous to that used for the presentation and evaluation of wavefront errors. In conjunction with the local phase transfer function (LPTF) it can be used for maximally efficient specification and correction of imaging system pupil errors. The LOQF and LPTF are respectively equivalent to the global modulation transfer function (MTF) and phase transfer function (PTF) parts of the OTF. The LPTF is related to difference of the average of the errors in separated regions of the pupil. Figure

  19. Interrogation of electrical connector faults using miniaturized UWB sources

    NASA Astrophysics Data System (ADS)

    Tokgöz, Çaǧata; Dardona, Sameh

    2017-01-01

    A diagnostic method for the detection, identification, and characterization of precursors of faults due to partial insertion of pin-socket contacts within electrical connectors commonly used in avionics systems is presented. It is demonstrated that a miniaturized ultrawideband (UWB) source and a minispectrum analyzer can be employed to measure resonant frequency shifts in connector S parameters as a small and low-cost alternative to a large and expensive network analyzer. The transfer function of an electrical connector is represented as a ratio of the spectra measured using the spectrum analyzer with and without the connector. Alternatively, the transfer function is derived in terms of the connector S parameters and the reflection coefficients at both ports of the connector. The transfer function data obtained using this derivation agreed well with its representation as a measured spectral ratio. The derivation enabled the extraction of the connector S parameters from the measured transfer function data as a function of the insertion depth of a pin-socket contact within the connector. In comparison with the S parameters measured directly using a network analyzer at multiple insertion depths, the S parameters extracted from the measured transfer function showed consistent and reliable representation of the electrical connector fault. The results demonstrate the potential of integrating a low-cost miniaturized UWB device into a connector harness for real-time detection of precursors to partially inserted connector faults.

  20. Extending amulti-scale parameter regionalization (MPR) method by introducing parameter constrained optimization and flexible transfer functions

    NASA Astrophysics Data System (ADS)

    Klotz, Daniel; Herrnegger, Mathew; Schulz, Karsten

    2015-04-01

    A multi-scale parameter-estimation method, as presented by Samaniego et al. (2010), is implemented and extended for the conceptual hydrological model COSERO. COSERO is a HBV-type model that is specialized for alpine-environments, but has been applied over a wide range of basins all over the world (see: Kling et al., 2014 for an overview). Within the methodology available small-scale information (DEM, soil texture, land cover, etc.) is used to estimate the coarse-scale model parameters by applying a set of transfer-functions (TFs) and subsequent averaging methods, whereby only TF hyper-parameters are optimized against available observations (e.g. runoff data). The parameter regionalisation approach was extended in order to allow for a more meta-heuristical handling of the transfer-functions. The two main novelties are: 1. An explicit introduction of constrains into parameter estimation scheme: The constraint scheme replaces invalid parts of the transfer-function-solution space with valid solutions. It is inspired by applications in evolutionary algorithms and related to the combination of learning and evolution. This allows the consideration of physical and numerical constraints as well as the incorporation of a priori modeller-experience into the parameter estimation. 2. Spline-based transfer-functions: Spline-based functions enable arbitrary forms of transfer-functions: This is of importance since in many cases the general relationship between sub-grid information and parameters are known, but not the form of the transfer-function itself. The contribution presents the results and experiences with the adopted method and the introduced extensions. Simulation are performed for the pre-alpine/alpine Traisen catchment in Lower Austria. References: Samaniego, L., Kumar, R., Attinger, S. (2010): Multiscale parameter regionalization of a grid-based hydrologic model at the mesoscale, Water Resour. Res., doi: 10.1029/2008WR007327 Kling, H., Stanzel, P., Fuchs, M., and Nachtnebel, H. P. (2014): Performance of the COSERO precipitation-runoff model under non-stationary conditions in basins with different climates, Hydrolog. Sci. J., doi: 10.1080/02626667.2014.959956.

  1. Bidirectional plant canopy reflection models derived from the radiation transfer equation

    NASA Technical Reports Server (NTRS)

    Beeth, D. R.

    1975-01-01

    A collection of bidirectional canopy reflection models was obtained from the solution of the radiation transfer equation for a horizontally homogeneous canopy. A phase function is derived for a collection of bidirectionally reflecting and transmitting planar elements characterized geometrically by slope and azimuth density functions. Two approaches to solving the radiation transfer equation for the canopy are presented. One approach factors the radiation transfer equation into a solvable set of three first-order linear differential equations by assuming that the radiation field within the canopy can be initially approximated by three components: uniformly diffuse downwelling, uniformly diffuse upwelling, and attenuated specular. The solution to these equations, which can be iterated to any degree of accuracy, was used to obtain overall canopy reflection from the formal solution to the radiation transfer equation. A programable solution to canopy overall bidirectional reflection is given for this approach. The special example of Lambertian leaves with constant leaf bidirectional reflection and scattering functions is considered, and a programmable solution for this example is given. The other approach to solving the radiation transfer equation, a generalized Chandrasekhar technique, is presented in the appendix.

  2. Voluntary activation of biceps-to-triceps and deltoid-to-triceps transfers in quadriplegia.

    PubMed

    Peterson, Carrie L; Bednar, Michael S; Bryden, Anne M; Keith, Michael W; Perreault, Eric J; Murray, Wendy M

    2017-01-01

    The biceps or the posterior deltoid can be transferred to improve elbow extension function for many individuals with C5 or C6 quadriplegia. Maximum strength after elbow reconstruction is variable; the patient's ability to voluntarily activate the transferred muscle to extend the elbow may contribute to the variability. We compared voluntary activation during maximum isometric elbow extension following biceps transfer (n = 5) and deltoid transfer (n = 6) in three functional postures. Voluntary activation was computed as the elbow extension moment generated during maximum voluntary effort divided by the moment generated with full activation, which was estimated via electrical stimulation. Voluntary activation was on average 96% after biceps transfer and not affected by posture. Individuals with deltoid transfer demonstrated deficits in voluntary activation, which differed by posture (80% in horizontal plane, 69% in overhead reach, and 70% in weight-relief), suggesting inadequate motor re-education after deltoid transfer. Overall, individuals with a biceps transfer better activated their transferred muscle than those with a deltoid transfer. This difference in neural control augmented the greater force-generating capacity of the biceps leading to increased elbow extension strength after biceps transfer (average 9.37 N-m across postures) relative to deltoid transfer (average 2.76 N-m across postures) in our study cohort.

  3. Voluntary activation of biceps-to-triceps and deltoid-to-triceps transfers in quadriplegia

    PubMed Central

    Peterson, Carrie L.; Bednar, Michael S.; Bryden, Anne M.; Keith, Michael W.; Perreault, Eric J.; Murray, Wendy M.

    2017-01-01

    The biceps or the posterior deltoid can be transferred to improve elbow extension function for many individuals with C5 or C6 quadriplegia. Maximum strength after elbow reconstruction is variable; the patient’s ability to voluntarily activate the transferred muscle to extend the elbow may contribute to the variability. We compared voluntary activation during maximum isometric elbow extension following biceps transfer (n = 5) and deltoid transfer (n = 6) in three functional postures. Voluntary activation was computed as the elbow extension moment generated during maximum voluntary effort divided by the moment generated with full activation, which was estimated via electrical stimulation. Voluntary activation was on average 96% after biceps transfer and not affected by posture. Individuals with deltoid transfer demonstrated deficits in voluntary activation, which differed by posture (80% in horizontal plane, 69% in overhead reach, and 70% in weight-relief), suggesting inadequate motor re-education after deltoid transfer. Overall, individuals with a biceps transfer better activated their transferred muscle than those with a deltoid transfer. This difference in neural control augmented the greater force-generating capacity of the biceps leading to increased elbow extension strength after biceps transfer (average 9.37 N-m across postures) relative to deltoid transfer (average 2.76 N-m across postures) in our study cohort. PMID:28253262

  4. Horizontal functional gene transfer from bacteria to fishes.

    PubMed

    Sun, Bao-Fa; Li, Tong; Xiao, Jin-Hua; Jia, Ling-Yi; Liu, Li; Zhang, Peng; Murphy, Robert W; He, Shun-Min; Huang, Da-Wei

    2015-12-22

    Invertebrates can acquire functional genes via horizontal gene transfer (HGT) from bacteria but fishes are not known to do so. We provide the first reliable evidence of one HGT event from marine bacteria to fishes. The HGT appears to have occurred after emergence of the teleosts. The transferred gene is expressed and regulated developmentally. Its successful integration and expression may change the genetic and metabolic repertoire of fishes. In addition, this gene contains conserved domains and similar tertiary structures in fishes and their putative donor bacteria. Thus, it may function similarly in both groups. Evolutionary analyses indicate that it evolved under purifying selection, further indicating its conserved function. We document the first likely case of HGT of functional gene from prokaryote to fishes. This discovery certifies that HGT can influence vertebrate evolution.

  5. Characterizing short-term stability for Boolean networks over any distribution of transfer functions

    DOE PAGES

    Seshadhri, C.; Smith, Andrew M.; Vorobeychik, Yevgeniy; ...

    2016-07-05

    Here we present a characterization of short-term stability of random Boolean networks under arbitrary distributions of transfer functions. Given any distribution of transfer functions for a random Boolean network, we present a formula that decides whether short-term chaos (damage spreading) will happen. We provide a formal proof for this formula, and empirically show that its predictions are accurate. Previous work only works for special cases of balanced families. Finally, it has been observed that these characterizations fail for unbalanced families, yet such families are widespread in real biological networks.

  6. Matrix Transfer Function Design for Flexible Structures: An Application

    NASA Technical Reports Server (NTRS)

    Brennan, T. J.; Compito, A. V.; Doran, A. L.; Gustafson, C. L.; Wong, C. L.

    1985-01-01

    The application of matrix transfer function design techniques to the problem of disturbance rejection on a flexible space structure is demonstrated. The design approach is based on parameterizing a class of stabilizing compensators for the plant and formulating the design specifications as a constrained minimization problem in terms of these parameters. The solution yields a matrix transfer function representation of the compensator. A state space realization of the compensator is constructed to investigate performance and stability on the nominal and perturbed models. The application is made to the ACOSSA (Active Control of Space Structures) optical structure.

  7. Testing and development of transfer functions for weighing precipitation gauges in WMO-SPICE

    NASA Astrophysics Data System (ADS)

    Kochendorfer, John; Nitu, Rodica; Wolff, Mareile; Mekis, Eva; Rasmussen, Roy; Baker, Bruce; Earle, Michael E.; Reverdin, Audrey; Wong, Kai; Smith, Craig D.; Yang, Daqing; Roulet, Yves-Alain; Meyers, Tilden; Buisan, Samuel; Isaksen, Ketil; Brækkan, Ragnar; Landolt, Scott; Jachcik, Al

    2018-02-01

    Weighing precipitation gauges are used widely for the measurement of all forms of precipitation, and are typically more accurate than tipping-bucket precipitation gauges. This is especially true for the measurement of solid precipitation; however, weighing precipitation gauge measurements must still be adjusted for undercatch in snowy, windy conditions. In WMO-SPICE (World Meteorological Organization Solid Precipitation InterComparison Experiment), different types of weighing precipitation gauges and shields were compared, and adjustments were determined for the undercatch of solid precipitation caused by wind. For the various combinations of gauges and shields, adjustments using both new and previously existing transfer functions were evaluated. For most of the gauge and shield combinations, previously derived transfer functions were found to perform as well as those more recently derived. This indicates that wind shield type (or lack thereof) is more important in determining the magnitude of wind-induced undercatch than the type of weighing precipitation gauge. It also demonstrates the potential for widespread use of the previously developed transfer functions. Another overarching result was that, in general, the more effective shields, which were associated with smaller unadjusted errors, also produced more accurate measurements after adjustment. This indicates that although transfer functions can effectively reduce measurement biases, effective wind shielding is still required for the most accurate measurement of solid precipitation.

  8. Dual Nerve Transfers for Restoration of Shoulder Function After Brachial Plexus Avulsion Injury.

    PubMed

    Chu, Bin; Wang, Huan; Chen, Liang; Gu, Yudong; Hu, Shaonan

    2016-06-01

    The purpose of this study was to investigate the effectiveness of shoulder function restoration by dual nerve transfers, spinal accessory nerve to the suprascapular nerve and 2 intercostal nerves to the anterior branch of the axillary nerve, in patients with shoulder paralysis that resulted from brachial plexus avulsion injury. It was a retrospective analysis to assess the impact of a variety of factors on reanimation of shoulder functions with dual nerve transfers. A total of 19 patients were included in this study. Most of these patients sustained avulsions of C5, C6, and C7 nerve roots (16 patients). Three of them had avulsions of C5 and C6 roots only. Through a posterior approach, direct coaptation of the intercostal nerves and the anterior branch of the axillary nerve was performed, along with accessory nerve transfer to the suprascapular nerve. Satisfactory shoulder function recovery (93.83° of shoulder abduction and 54.00° of external rotation on average) was achieved after a 62-month follow-up. This dual nerve transfer procedure provided us with a reliable and effective method for shoulder function reconstruction after brachial plexus root avulsion, especially C5/C6/C7 avulsion. The level of evidence is therapeutic IV.

  9. Automatic transfer function generation for volume rendering of high-resolution x-ray 3D digital mammography images

    NASA Astrophysics Data System (ADS)

    Alyassin, Abdal M.

    2002-05-01

    3D Digital mammography (3DDM) is a new technology that provides high resolution X-ray breast tomographic data. Like any other tomographic medical imaging modalities, viewing a stack of tomographic images may require time especially if the images are of large matrix size. In addition, it may cause difficulty to conceptually construct 3D breast structures. Therefore, there is a need to readily visualize the data in 3D. However, one of the issues that hinder the usage of volume rendering (VR) is finding an automatic way to generate transfer functions that efficiently map the important diagnostic information in the data. We have developed a method that randomly samples the volume. Based on the mean and the standard deviation of these samples, the technique determines the lower limit and upper limit of a piecewise linear ramp transfer function. We have volume rendered several 3DDM data using this technique and compared visually the outcome with the result from a conventional automatic technique. The transfer function generated through the proposed technique provided superior VR images over the conventional technique. Furthermore, the improvement in the reproducibility of the transfer function correlated with the number of samples taken from the volume at the expense of the processing time.

  10. Regression analysis and transfer function in estimating the parameters of central pulse waves from brachial pulse wave.

    PubMed

    Chai Rui; Li Si-Man; Xu Li-Sheng; Yao Yang; Hao Li-Ling

    2017-07-01

    This study mainly analyzed the parameters such as ascending branch slope (A_slope), dicrotic notch height (Hn), diastolic area (Ad) and systolic area (As) diastolic blood pressure (DBP), systolic blood pressure (SBP), pulse pressure (PP), subendocardial viability ratio (SEVR), waveform parameter (k), stroke volume (SV), cardiac output (CO) and peripheral resistance (RS) of central pulse wave invasively and non-invasively measured. These parameters extracted from the central pulse wave invasively measured were compared with the parameters measured from the brachial pulse waves by a regression model and a transfer function model. The accuracy of the parameters which were estimated by the regression model and the transfer function model was compared too. Our findings showed that in addition to the k value, the above parameters of the central pulse wave and the brachial pulse wave invasively measured had positive correlation. Both the regression model parameters including A_slope, DBP, SEVR and the transfer function model parameters had good consistency with the parameters invasively measured, and they had the same effect of consistency. The regression equations of the three parameters were expressed by Y'=a+bx. The SBP, PP, SV, CO of central pulse wave could be calculated through the regression model, but their accuracies were worse than that of transfer function model.

  11. Analysis of the transfer function for layered piezoelectric ultrasonic sensors

    NASA Astrophysics Data System (ADS)

    Gutiérrrez-Reyes, E.; García-Segundo, C.; García-Valenzuela, A.; Reyes-Ramírez, B.; Gutiérrez-Juárez, G.; Guadarrama-Santana, A.

    2017-06-01

    We model theoretically the voltage response to an acoustic pulse of a multilayer system forming a low noise capacitive sensor including a Polyvinylidene Fluoride piezoelectric film. First we model a generic piezoelectric detector consisting of a piezoelectric film between two metallic electrodes that are the responsible to convert the acoustic signal into a voltage signal. Then we calculate the pressure-to-voltage transfer function for a N-layer piezo-electric capacitor detector, allowing to study the effects of the electrode and protective layers thickness in typical layered piezoelectric sensors. The derived transfer function, when multiplied by the Fourier transform of the incident acoustic pulse, gives the voltage electric response in the frequency domain. An important concern regarding the transfer function is that it may have zeros at specific frequencies, and thus inverting the voltage Fourier transform of the pulse to recover the pressure signal in the time domain is not always, in principle, possible. Our formulas can be used to predict the existence and locations of such zeroes. We illustrate the use of the transfer function by predicting the electric signal generated at a multilayer piezoelectric sensor to an ultrasonic pulse generated photoacoustically by a laser pulse at a three media system with impedance mismatch. This theoretical calculations are compared with our own experimental measurements.

  12. Cyclodextrin-enhanced extraction and energy transfer of carcinogens in complex oil environments.

    PubMed

    Serio, Nicole; Chanthalyma, Chitapom; Prignano, Lindsey; Levine, Mindy

    2013-11-27

    Reported herein is the use of γ-cyclodextrin for two tandem functions: (a) the extraction of carcinogenic polycyclic aromatic hydrocarbons (PAHs) from oil samples into aqueous solution and (b) the promotion of highly efficient energy transfer from the newly extracted PAHs to a high-quantum-yield fluorophore. The extraction proceeded in moderate to good efficiencies, and the resulting cyclodextrin-promoted energy transfer led to a new, brightly fluorescent signal in aqueous solution. The resulting dual-function system (extraction followed by energy transfer) has significant relevance in the environmental detection and cleanup of oil-spill-related carcinogens.

  13. Release strategies for making transferable semiconductor structures, devices and device components

    DOEpatents

    Rogers, John A; Nuzzo, Ralph G; Meitl, Matthew; Ko, Heung Cho; Yoon, Jongseung; Menard, Etienne; Baca, Alfred J

    2014-11-25

    Provided are methods for making a device or device component by providing a multilayer structure having a plurality of functional layers and a plurality of release layers and releasing the functional layers from the multilayer structure by separating one or more of the release layers to generate a plurality of transferable structures. The transferable structures are printed onto a device substrate or device component supported by a device substrate. The methods and systems provide means for making high-quality and low-cost photovoltaic devices, transferable semiconductor structures, (opto-)electronic devices and device components.

  14. Release strategies for making transferable semiconductor structures, devices and device components

    DOEpatents

    Rogers, John A [Champaign, IL; Nuzzo, Ralph G [Champaign, IL; Meitl, Matthew [Raleigh, NC; Ko, Heung Cho [Urbana, IL; Yoon, Jongseung [Urbana, IL; Menard, Etienne [Durham, NC; Baca, Alfred J [Urbana, IL

    2011-04-26

    Provided are methods for making a device or device component by providing a multilayer structure having a plurality of functional layers and a plurality of release layers and releasing the functional layers from the multilayer structure by separating one or more of the release layers to generate a plurality of transferable structures. The transferable structures are printed onto a device substrate or device component supported by a device substrate. The methods and systems provide means for making high-quality and low-cost photovoltaic devices, transferable semiconductor structures, (opto-)electronic devices and device components.

  15. A characterization of low luminance static and dynamic modulation transfer function curves for P-1, P-43, and P-53 phosphorus

    NASA Astrophysics Data System (ADS)

    Beasley, Howard H.; Martin, John S.; Klymenko, Victor; Harding, Thomas H.; Verona, Robert W.; Rash, Clarence E.

    1995-07-01

    A counterphase modulation technique is used to measure the static and dynamic modulation transfer functions for three phosphorus of current interest to U.S. Army aviation helmet-mounted displays (P-1, P-43, and P-53). A family of modulation transfer curves, one for each temporal frequency, is presented for each phosphorus. The measured MFT curves generally support the supposition that phosphorus persistence is a critical parameter in the ability of a CRT display to accurately reproduce contrast modulation transfer in dynamic environments.

  16. Release strategies for making transferable semiconductor structures, devices and device components

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rogers, John A.; Nuzzo, Ralph G.; Meitl, Matthew

    2016-05-24

    Provided are methods for making a device or device component by providing a multi layer structure having a plurality of functional layers and a plurality of release layers and releasing the functional layers from the multilayer structure by separating one or more of the release layers to generate a plurality of transferable structures. The transferable structures are printed onto a device substrate or device component supported by a device substrate. The methods and systems provide means for making high-quality and low-cost photovoltaic devices, transferable semiconductor structures, (opto-)electronic devices and device components.

  17. Filtering Non-Linear Transfer Functions on Surfaces.

    PubMed

    Heitz, Eric; Nowrouzezahrai, Derek; Poulin, Pierre; Neyret, Fabrice

    2014-07-01

    Applying non-linear transfer functions and look-up tables to procedural functions (such as noise), surface attributes, or even surface geometry are common strategies used to enhance visual detail. Their simplicity and ability to mimic a wide range of realistic appearances have led to their adoption in many rendering problems. As with any textured or geometric detail, proper filtering is needed to reduce aliasing when viewed across a range of distances, but accurate and efficient transfer function filtering remains an open problem for several reasons: transfer functions are complex and non-linear, especially when mapped through procedural noise and/or geometry-dependent functions, and the effects of perspective and masking further complicate the filtering over a pixel's footprint. We accurately solve this problem by computing and sampling from specialized filtering distributions on the fly, yielding very fast performance. We investigate the case where the transfer function to filter is a color map applied to (macroscale) surface textures (like noise), as well as color maps applied according to (microscale) geometric details. We introduce a novel representation of a (potentially modulated) color map's distribution over pixel footprints using Gaussian statistics and, in the more complex case of high-resolution color mapped microsurface details, our filtering is view- and light-dependent, and capable of correctly handling masking and occlusion effects. Our approach can be generalized to filter other physical-based rendering quantities. We propose an application to shading with irradiance environment maps over large terrains. Our framework is also compatible with the case of transfer functions used to warp surface geometry, as long as the transformations can be represented with Gaussian statistics, leading to proper view- and light-dependent filtering results. Our results match ground truth and our solution is well suited to real-time applications, requires only a few lines of shader code (provided in supplemental material, which can be found on the Computer Society Digital Library at http://doi.ieeecomputersociety.org/10.1109/TVCG.2013.102), is high performance, and has a negligible memory footprint.

  18. Enhancement of humidity sensitivity of graphene through functionalization with polyethylenimine

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ben Aziza, Zeineb; School of Electrical and Electronics Engineering, Nanyang Technological University, Block S1, 50 Nanyang Avenue, Singapore 639798; XLIM UMR 7252 Université de Limoges/CNRS, 123 Avenue Albert Thomas, 87060 Limoges

    2015-09-28

    In this work, we show that the sensing performance of graphene based humidity sensors can be largely improved through polymer functionalization. Chemical vapor deposited graphene is functionalized with amine rich polymer, leading to electron transfer from amine groups in the polymer to graphene. The functionalized graphene humidity sensor has demonstrated good sensitivity, recovery, and repeatability. Charge transfer between the functionalized graphene and water molecules and the sensing mechanism are studied systemically using field effect transistor geometry and scanning Kelvin probe microscopy.

  19. The First Experience of Triple Nerve Transfer in Proximal Radial Nerve Palsy.

    PubMed

    Emamhadi, Mohammadreza; Andalib, Sasan

    2018-01-01

    Injury to distal portion of posterior cord of brachial plexus leads to palsy of radial and axillary nerves. Symptoms are usually motor deficits of the deltoid muscle; triceps brachii muscle; and extensor muscles of the wrist, thumb, and fingers. Tendon transfers, nerve grafts, and nerve transfers are options for surgical treatment of proximal radial nerve palsy to restore some motor functions. Tendon transfer is painful, requires a long immobilization, and decreases donor muscle strength; nevertheless, nerve transfer produces promising outcomes. We present a patient with proximal radial nerve palsy following a blunt injury undergoing triple nerve transfer. The patient was involved in a motorcycle accident with complete palsy of the radial and axillary nerves. After 6 months, on admission, he showed spontaneous recovery of axillary nerve palsy, but radial nerve palsy remained. We performed triple nerve transfer, fascicle of ulnar nerve to long head of the triceps branch of radial nerve, flexor digitorum superficialis branch of median nerve to extensor carpi radialis brevis branch of radial nerve, and flexor carpi radialis branch of median nerve to posterior interosseous nerve, for restoration of elbow, wrist, and finger extensions, respectively. Our experience confirmed functional elbow, wrist, and finger extensions in the patient. Triple nerve transfer restores functions of the upper limb in patients with debilitating radial nerve palsy after blunt injuries. Copyright © 2017 Elsevier Inc. All rights reserved.

  20. Transfer of extensor carpi radialis brevis as an extensor to extensor motor transfer (EEMT) in ulnar nerve palsy.

    PubMed

    Jamali, Allah Rakha; Bhatti, Anisuddin; Mehboob, Ghulam

    2006-07-01

    To evaluate functional outcome and correction of deformity with extensor carpiradialis brevis motor transfer to replace the intrinsic muscles as an extensor to extensor motor transfer (EEMT). This was a prospective observational study with one group pretest posttest design conducted from 1996 to 2004. Convenience sampling technique was used and the sample size was twenty one. The independent variable was transfer of extensor carpiradialis brevis to replace the intrinsic muscles. The dependent variable was functional outcome and the correction of deformity. The extraneous variables were age, sex interval between injury and transfer as well as local factors related to wound and grafts used. The average follow up was 22.5 months. The mean preoperative unassisted extensor lag was 56.79 +/- 10.39 which improved to 9.6% +/- 5.4 (correction of 83%) at six months after surgery. With open hand assessment 76.19% reported good to excellent results, while 79.89% achieved good to excellent results with closed hand assessment. The mechanism of closing was good to excellent in 89.42% cases, however only 71.42% patients considered their hands good to excellent. Significant problems were seen with use of tendoachilles as a graft. Extensor carpiradialis brevis transfer to replace the intrinsic muscles as an extensor to extensor motor transfer can achieve good functional outcome as well as correction of deformity despite shortcomings in physical rehabilitation.

  1. Proton transfer pathways, energy landscape, and kinetics in creatine-water systems.

    PubMed

    Ivchenko, Olga; Whittleston, Chris S; Carr, Joanne M; Imhof, Petra; Goerke, Steffen; Bachert, Peter; Wales, David J

    2014-02-27

    We study the exchange processes of the metabolite creatine, which is present in both tumorous and normal tissues and has NH2 and NH groups that can transfer protons to water. Creatine produces chemical exchange saturation transfer (CEST) contrast in magnetic resonance imaging (MRI). The proton transfer pathway from zwitterionic creatine to water is examined using a kinetic transition network constructed from the discrete path sampling approach and an approximate quantum-chemical energy function, employing the self-consistent-charge density-functional tight-binding (SCC-DFTB) method. The resulting potential energy surface is visualized by constructing disconnectivity graphs. The energy landscape consists of two distinct regions corresponding to the zwitterionic creatine structures and deprotonated creatine. The activation energy that characterizes the proton transfer from the creatine NH2 group to water was determined from an Arrhenius fit of rate constants as a function of temperature, obtained from harmonic transition state theory. The result is in reasonable agreement with values obtained in water exchange spectroscopy (WEX) experiments.

  2. Nano-inspired fluidic interactivity for boiling heat transfer: impact and criteria

    PubMed Central

    Kim, Beom Seok; Choi, Geehong; Shin, Sangwoo; Gemming, Thomas; Cho, Hyung Hee

    2016-01-01

    The enhancement of boiling heat transfer, the most powerful energy-transferring technology, will lead to milestones in the development of high-efficiency, next-generation energy systems. Perceiving nano-inspired interface functionalities from their rough morphologies, we demonstrate interface-induced liquid refreshing is essential to improve heat transfer by intrinsically avoiding Leidenfrost phenomenon. High liquid accessibility of hemi-wicking and catalytic nucleation, triggered by the morphological and hydrodynamic peculiarities of nano-inspired interfaces, contribute to the critical heat flux (CHF) and the heat transfer coefficient (HTC). Our experiments show CHF is a function of universal hydrodynamic characteristics involving interfacial liquid accessibility and HTC is improved with a higher probability of smaller nuclei with less superheat. Considering the interface-induced and bulk liquid accessibility at boiling, we discuss functionalizing the interactivity between an interface and a counteracting fluid seeking to create a novel interface, a so-called smart interface, for a breakthrough in boiling and its pragmatic application in energy systems. PMID:27708341

  3. Acoustic radiation from weakly wrinkled premixed flames

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lieuwen, Tim; Mohan, Sripathi; Rajaram, Rajesh

    2006-01-01

    This paper describes a theoretical analysis of acoustic radiation from weakly wrinkled (i.e., u'/S{sub L}<1) premixed flames. Specifically, it determines the transfer function relating the spectrum of the acoustic pressure oscillations, P'({omega}), to that of the turbulent velocity fluctuations in the approach flow, U'({omega}). In the weakly wrinkled limit, this transfer function is local in frequency space; i.e., velocity fluctuations at a frequency {omega} distort the flame and generate sound at the same frequency. This transfer function primarily depends upon the flame Strouhal number St (based on mean flow velocity and flame length) and the correlation length, {lambda}, of themore » flow fluctuations. For cases where the ratio of the correlation length and duct radius {lambda}/a>>1, the acoustic pressure and turbulent velocity power spectra are related by P'({omega})-{omega}{sup 2}U'({omega}) and P'({omega})-U'({omega}) for St<<1 and St>>1, respectively. For cases where {lambda}/a<<1, the transfer functions take the form P'({omega})-{omega}{sup 2}({lambda}/a){sup 2}U'({omega}) and P'({omega})-{omega}{sup 2}({lambda}/a){sup 2}({psi}-{delta}ln({lambda}/a))U'({omega}) for St<<1 and St>>1, respectively, where (PS) and {delta} are constants. The latter result demonstrates that this transfer function does not exhibit a simple power law relationship in the high frequency region of the spectra. The simultaneous dependence of this pressure-velocity transfer function upon the Strouhal number and correlation length suggests a mechanism for the experimentally observed maximum in acoustic spectra and provides some insight into the controversy in the literature over how this peak should scale with the flame Strouhal number.« less

  4. Accounting for substitution and spatial heterogeneity in a labelled choice experiment.

    PubMed

    Lizin, S; Brouwer, R; Liekens, I; Broeckx, S

    2016-10-01

    Many environmental valuation studies using stated preferences techniques are single-site studies that ignore essential spatial aspects, including possible substitution effects. In this paper substitution effects are captured explicitly in the design of a labelled choice experiment and the inclusion of different distance variables in the choice model specification. We test the effect of spatial heterogeneity on welfare estimates and transfer errors for minor and major river restoration works, and the transferability of river specific utility functions, accounting for key variables such as site visitation, spatial clustering and income. River specific utility functions appear to be transferable, resulting in low transfer errors. However, ignoring spatial heterogeneity increases transfer errors. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. System and method for characterizing synthesizing and/or canceling out acoustic signals from inanimate sound sources

    DOEpatents

    Holzrichter, John F.; Burnett, Greg C.; Ng, Lawrence C.

    2003-01-01

    A system and method for characterizing, synthesizing, and/or canceling out acoustic signals from inanimate sound sources is disclosed. Propagating wave electromagnetic sensors monitor excitation sources in sound producing systems, such as machines, musical instruments, and various other structures. Acoustical output from these sound producing systems is also monitored. From such information, a transfer function characterizing the sound producing system is generated. From the transfer function, acoustical output from the sound producing system may be synthesized or canceled. The methods disclosed enable accurate calculation of matched transfer functions relating specific excitations to specific acoustical outputs. Knowledge of such signals and functions can be used to effect various sound replication, sound source identification, and sound cancellation applications.

  6. Characterizing, synthesizing, and/or canceling out acoustic signals from sound sources

    DOEpatents

    Holzrichter, John F [Berkeley, CA; Ng, Lawrence C [Danville, CA

    2007-03-13

    A system for characterizing, synthesizing, and/or canceling out acoustic signals from inanimate and animate sound sources. Electromagnetic sensors monitor excitation sources in sound producing systems, such as animate sound sources such as the human voice, or from machines, musical instruments, and various other structures. Acoustical output from these sound producing systems is also monitored. From such information, a transfer function characterizing the sound producing system is generated. From the transfer function, acoustical output from the sound producing system may be synthesized or canceled. The systems disclosed enable accurate calculation of transfer functions relating specific excitations to specific acoustical outputs. Knowledge of such signals and functions can be used to effect various sound replication, sound source identification, and sound cancellation applications.

  7. Worry spreads: interpersonal transfer of problem-related anxiety.

    PubMed

    Parkinson, Brian; Simons, Gwenda

    2012-01-01

    This paper distinguishes processes potentially contributing to interpersonal anxiety transfer, including object-directed social appraisal, empathic worry, and anxiety contagion, and reviews evidence for their operation. We argue that these anxiety-transfer processes may be exploited strategically when attempting to regulate relationship partners' emotion. More generally, anxiety may serve as either a warning signal to other people about threat (alerting function) or an appeal for emotional support or practical help (comfort-seeking function). Tensions between these two interpersonal functions may account for mutually incongruent interpersonal responses to expressed anxiety, including mistargeted interpersonal regulation attempts. Because worry waxes and wanes over time as a function of other people's ongoing reactions, interpersonal interventions may help to alleviate some of its maladaptive consequences.

  8. Acute repair of traumatic pan-brachial plexus injury: technical considerations and approaches.

    PubMed

    Abou-Al-Shaar, Hussam; Karsy, Michael; Ravindra, Vijay; Joyce, Evan; Mahan, Mark A

    2018-01-01

    Particularly challenging after complete brachial plexus avulsion is reestablishing effective hand function, due to limited neurological donors to reanimate the arm. Acute repair of avulsion injuries may enable reinnervation strategies for achieving hand function. This patient presented with pan-brachial plexus injury. Given its irreparable nature, the authors recommended multistage reconstruction, including contralateral C-7 transfer for hand function, multiple intercostal nerves for shoulder/triceps function, shoulder fusion, and spinal accessory nerve-to-musculocutaneous nerve transfer for elbow flexion. The video demonstrates distal contraction from electrical stimulation of the avulsed roots. Single neurorrhaphy of the contralateral C-7 transfer was performed along with a retrosternocleidomastoid approach. The video can be found here: https://youtu.be/GMPfno8sK0U .

  9. System and method for characterizing, synthesizing, and/or canceling out acoustic signals from inanimate sound sources

    DOEpatents

    Holzrichter, John F; Burnett, Greg C; Ng, Lawrence C

    2013-05-21

    A system and method for characterizing, synthesizing, and/or canceling out acoustic signals from inanimate sound sources is disclosed. Propagating wave electromagnetic sensors monitor excitation sources in sound producing systems, such as machines, musical instruments, and various other structures. Acoustical output from these sound producing systems is also monitored. From such information, a transfer function characterizing the sound producing system is generated. From the transfer function, acoustical output from the sound producing system may be synthesized or canceled. The methods disclosed enable accurate calculation of matched transfer functions relating specific excitations to specific acoustical outputs. Knowledge of such signals and functions can be used to effect various sound replication, sound source identification, and sound cancellation applications.

  10. System and method for characterizing, synthesizing, and/or canceling out acoustic signals from inanimate sound sources

    DOEpatents

    Holzrichter, John F.; Burnett, Greg C.; Ng, Lawrence C.

    2007-10-16

    A system and method for characterizing, synthesizing, and/or canceling out acoustic signals from inanimate sound sources is disclosed. Propagating wave electromagnetic sensors monitor excitation sources in sound producing systems, such as machines, musical instruments, and various other structures. Acoustical output from these sound producing systems is also monitored. From such information, a transfer function characterizing the sound producing system is generated. From the transfer function, acoustical output from the sound producing system may be synthesized or canceled. The methods disclosed enable accurate calculation of matched transfer functions relating specific excitations to specific acoustical outputs. Knowledge of such signals and functions can be used to effect various sound replication, sound source identification, and sound cancellation applications.

  11. The Relation of Self Variables to Transfer Student Success as Measured by Academic, Psychological, and Career Functioning

    ERIC Educational Resources Information Center

    Ling, Thomson Joseph

    2006-01-01

    Research has suggested that transfer students experience difficulty in many domains however limited research has examined the variables associated with transfer student success. The present study examined transfer student success using a sample of 163 first-year transfer students at a large mid-Atlantic university. The mean age of the participants…

  12. An investigation of rotor noise generation by aerodynamic disturbance. [aeroacoustic transfer functions

    NASA Technical Reports Server (NTRS)

    Whitfield, C. E.

    1977-01-01

    An open rotor was considered as a process for converting an unsteady velocity inflow into sound radiation. With the aid of crude assumptions, aero-acoustic transfer functions were defined theoretically for both discrete frequency and broad band noise. A study of the validity of these transfer functions yielded results which show good agreement at discrete frequencies though slightly less good for broad band noise. Agreement in both cases holds over three or more decades of the relevant parameters. A rotating hot wire anemometry system consisting of a single hot wire probe mounted in the nose cone of the rotor was used to quantify fluctuations in the airflow onto a single rotor blade for the transfer function results. Further theoretical analysis revealed that the sound field can be expressed in terms of blade-to-blade correlations in the airflow, and results from two probes rotating simultaneously were modelled mathematically and inserted in the theory. Preliminary results snow encouraging agreement with experimental data.

  13. Temporal modulation transfer functions in auditory receptor fibres of the locust ( Locusta migratoria L.).

    PubMed

    Prinz, P; Ronacher, B

    2002-08-01

    The temporal resolution of auditory receptors of locusts was investigated by applying noise stimuli with sinusoidal amplitude modulations and by computing temporal modulation transfer functions. These transfer functions showed mostly bandpass characteristics, which are rarely found in other species at the level of receptors. From the upper cut-off frequencies of the modulation transfer functions the minimum integration times were calculated. Minimum integration times showed no significant correlation to the receptor spike rates but depended strongly on the body temperature. At 20 degrees C the average minimum integration time was 1.7 ms, dropping to 0.95 ms at 30 degrees C. The values found in this study correspond well to the range of minimum integration times found in birds and mammals. Gap detection is another standard paradigm to investigate temporal resolution. In locusts and other grasshoppers application of this paradigm yielded values of the minimum detectable gap widths that are approximately twice as large than the minimum integration times reported here.

  14. Parameter Estimation of Actuators for Benchmark Active Control Technology (BACT) Wind Tunnel Model with Analysis of Wear and Aerodynamic Loading Effects

    NASA Technical Reports Server (NTRS)

    Waszak, Martin R.; Fung, Jimmy

    1998-01-01

    This report describes the development of transfer function models for the trailing-edge and upper and lower spoiler actuators of the Benchmark Active Control Technology (BACT) wind tunnel model for application to control system analysis and design. A simple nonlinear least-squares parameter estimation approach is applied to determine transfer function parameters from frequency response data. Unconstrained quasi-Newton minimization of weighted frequency response error was employed to estimate the transfer function parameters. An analysis of the behavior of the actuators over time to assess the effects of wear and aerodynamic load by using the transfer function models is also presented. The frequency responses indicate consistent actuator behavior throughout the wind tunnel test and only slight degradation in effectiveness due to aerodynamic hinge loading. The resulting actuator models have been used in design, analysis, and simulation of controllers for the BACT to successfully suppress flutter over a wide range of conditions.

  15. Transfer function verification and block diagram simplification of a very high-order distributed pole closed-loop servo by means of non-linear time-response simulation

    NASA Technical Reports Server (NTRS)

    Mukhopadhyay, A. K.

    1975-01-01

    Linear frequency domain methods are inadequate in analyzing the 1975 Viking Orbiter (VO75) digital tape recorder servo due to dominant nonlinear effects such as servo signal limiting, unidirectional servo control, and static/dynamic Coulomb friction. The frequency loop (speed control) servo of the VO75 tape recorder is used to illustrate the analytical tools and methodology of system redundancy elimination and high order transfer function verification. The paper compares time-domain performance parameters derived from a series of nonlinear time responses with the available experimental data in order to select the best possible analytical transfer function representation of the tape transport (mechanical segment of the tape recorder) from several possible candidates. The study also shows how an analytical time-response simulation taking into account most system nonlinearities can pinpoint system redundancy and overdesign stemming from a strictly empirical design approach. System order reduction is achieved through truncation of individual transfer functions and elimination of redundant blocks.

  16. Dimensional feature weighting utilizing multiple kernel learning for single-channel talker location discrimination using the acoustic transfer function.

    PubMed

    Takashima, Ryoichi; Takiguchi, Tetsuya; Ariki, Yasuo

    2013-02-01

    This paper presents a method for discriminating the location of the sound source (talker) using only a single microphone. In a previous work, the single-channel approach for discriminating the location of the sound source was discussed, where the acoustic transfer function from a user's position is estimated by using a hidden Markov model of clean speech in the cepstral domain. In this paper, each cepstral dimension of the acoustic transfer function is newly weighted, in order to obtain the cepstral dimensions having information that is useful for classifying the user's position. Then, this paper proposes a feature-weighting method for the cepstral parameter using multiple kernel learning, defining the base kernels for each cepstral dimension of the acoustic transfer function. The user's position is trained and classified by support vector machine. The effectiveness of this method has been confirmed by sound source (talker) localization experiments performed in different room environments.

  17. Technology transfer needs and experiences: The NASA Research Center perspective

    NASA Technical Reports Server (NTRS)

    Gross, Anthony R.

    1992-01-01

    Viewgraphs on technology transfer needs and experiences - the NASA Research Center perspective are provided. Topics covered include: functions of NASA, incentives and benefits, technology transfer mechanisms, economics of technology commercialization, examples, and conclusions.

  18. Experimental and Theoretical Performance of a Particle Velocity Vector Sensor in a Hybrid Acoustic Beamformer

    DTIC Science & Technology

    2009-12-01

    characterized first by the amplitude and phase relationship of their transfer functions relative to their co-located pressure microphone. The transfer...The Microflown acoustic particle velocity channels were characterized first by the amplitude and phase relationship of their transfer functions...k H k H k and  34Ĥ k . 3) The angular relationships of the velocity sensors to their respective MRAs were recorded and stored as the values of

  19. Friendly Extensible Transfer Tool Beta Version

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Collins, William P.; Gutierrez, Kenneth M.; McRee, Susan R.

    2016-04-15

    Often data transfer software is designed to meet specific requirements or apply to specific environments. Frequently, this requires source code integration for added functionality. An extensible data transfer framework is needed to more easily incorporate new capabilities, in modular fashion. Using FrETT framework, functionality may be incorporated (in many cases without need of source code) to handle new platform capabilities: I/O methods (e.g., platform specific data access), network transport methods, data processing (e.g., data compression.).

  20. Mimicking muscle activity with electrical stimulation

    NASA Astrophysics Data System (ADS)

    Johnson, Lise A.; Fuglevand, Andrew J.

    2011-02-01

    Functional electrical stimulation is a rehabilitation technology that can restore some degree of motor function in individuals who have sustained a spinal cord injury or stroke. One way to identify the spatio-temporal patterns of muscle stimulation needed to elicit complex upper limb movements is to use electromyographic (EMG) activity recorded from able-bodied subjects as a template for electrical stimulation. However, this requires a transfer function to convert the recorded (or predicted) EMG signals into an appropriate pattern of electrical stimulation. Here we develop a generalized transfer function that maps EMG activity into a stimulation pattern that modulates muscle output by varying both the pulse frequency and the pulse amplitude. We show that the stimulation patterns produced by this transfer function mimic the active state measured by EMG insofar as they reproduce with good fidelity the complex patterns of joint torque and joint displacement.

  1. Gate Tuning of Förster Resonance Energy Transfer in a Graphene - Quantum Dot FET Photo-Detector.

    PubMed

    Li, Ruifeng; Schneider, Lorenz Maximilian; Heimbrodt, Wolfram; Wu, Huizhen; Koch, Martin; Rahimi-Iman, Arash

    2016-06-20

    Graphene photo-detectors functionalized by colloidal quantum dots (cQDs) have been demonstrated to show effective photo-detection. Although the transfer of charge carriers or energy from the cQDs to graphene is not sufficiently understood, it is clear that the mechanism and efficiency of the transfer depends on the morphology of the interface between cQDs and graphene, which is determined by the shell of the cQDs in combination with its ligands. Here, we present a study of a graphene field-effect transistor (FET), which is functionalized by long-ligand CdSe/ZnS core/shell cQDs. Time-resolved photo-luminescence from the cQDs as a function of the applied gate voltage has been investigated in order to probe transfer dynamics in this system. Thereby, a clear modification of the photo-luminescence lifetime has been observed, indicating a change of the decay channels. Furthermore, we provide responsivities under a Förster-like energy transfer model as a function of the gate voltage in support of our findings. The model shows that by applying a back-gate voltage to the photo-detector, the absorption can be tuned with respect to the photo-luminescence of the cQDs. This leads to a tunable energy transfer rate across the interface of the photo-detector, which offers an opportunity to optimize the photo-detection.

  2. A density functional theory (DFT) and time-dependent density functional theory (TDDFT) study on optical transitions in oligo(p-phenylenevinylene)-fullerene dyads and the applicability to resonant energy transfer.

    PubMed

    Toivonen, Teemu L J; Hukka, Terttu I

    2007-06-07

    The optical transitions of three different size oligo(p-phenylenevinylene)-fullerene dyads (OPV(n)-MPC(60); n = 2-4) and of the corresponding separate molecules are studied using density functional theory (DFT) and time-dependent density functional theory. The DFT is used to determine the geometries and the electronic structures of the ground states. Transition energies and excited-state structures are obtained from the TDDFT calculations. Resonant energy transfer from OPV(n) to MPC(60) is also studied and the Fermi golden rule is used, along with two simple models to describe the electronic coupling to calculate the energy transfer rates. The hybrid-type PBE0 functional is used with a split-valence basis set augmented with a polarization function (SV(P)) in calculations and the calculated results are compared to the corresponding experimental results. The calculated PBE0 spectra of the OPV(n)-MPC(60) dyads correspond to the experimental spectra very well and are approximately sums of the absorption spectra of the separate OPV(n) and MPC(60) molecules. Also, the absorption energies of OPV(n) and MPC(60) and the emission energies of OPV(n) are predicted well with the PBE0 functional. The PBE0 calculated resonant energy transfer rates are in a good agreement with the experimental rates and show the existence of many possible pathways for energy transfer from the first excited singlet states of the OPV(n) molecules to the MPC(60) molecule.

  3. Correcting the vertical component of ocean bottom seismometers for the effects of tilt and compliance

    NASA Astrophysics Data System (ADS)

    Bell, S. W.; Forsyth, D. W.

    2013-12-01

    Typically there are very high noise levels at long periods on the horizontal components of ocean bottom seismographs due to the turbulent interaction of bottom currents with the seismometer package on the seafloor. When there is a slight tilt of the instrument, some of the horizontal displacement caused by bottom currents leaks onto the vertical component record, which can severely increase the apparent vertical noise. Another major type of noise, compliance noise, is created when pressure variations associated with water (gravity) waves deform the seabed. Compliance noise increases with decreasing water depth, and at water depths of less than a few hundred meters, compliance noise typically obscures most earthquake signals. Following Crawford and Webb (2000), we have developed a methodology for reducing these noise sources by 1-2 orders of magnitude, revealing many events that could not be distinguished before noise reduction. Our methodology relies on transfer functions between different channels. We calculate the compliance noise in the vertical displacement record by applying a transfer function to the differential pressure gauge record. Similarly, we calculate the tilt-induced bottom current noise in the vertical displacement record by applying a transfer function to the horizontal displacement records. Using data from the Cascadia experiment and other experiments, we calculate these transfer functions at a range of stations with varying tilts and water depths. The compliance noise transfer function depends strongly on water depth, and we provide a theoretical and empirical description of this dependence. Tilt noise appears to be very highly correlated with instrument design, with negligible tilt noise observed for the 'abalone' instruments from the Scripps Institute of Oceanography and significant tilt observed for the Woods Hole Oceanographic Institution instruments in the first year deployment of the Cascadia experiment. Tilt orientation appears relatively constant, but we observe significant day-to-day variation in tilt angle, requiring the calculation of a tilt transfer function for each individual day for optimum removal of bottom current noise. In removing the compliance noise, there is some distortion of the signal. We show how to correct for this distortion using theoretical and empirical transfer functions between pressure and displacement records for seismic signals.

  4. Effect of color on pilot performance and transfer functions using a full-spectrum, calligraphic, color display system

    NASA Technical Reports Server (NTRS)

    Chase, W. D.

    1976-01-01

    The use of blue and red color in out-of-window cockpit displays, in full-spectrum calligraphic computer-generated display systems, is studied with attention given to pilot stereographic depth perception and response to visual cues. Displays for vertical approach, with dynamic and frozen-range landing approach and perspective arrays, are analyzed. Pilot transfer function and the transfer function associated with the contrasted approach and perspective arrays are discussed. Out-of-window blue lights are perceived by pilots as indicating greater distance depth, red lights as indicating proximity. The computer-generated chromatic display was adapted to flight simulators for the tests.

  5. Head related transfer functions measurement and processing for the purpose of creating a spatial sound environment

    NASA Astrophysics Data System (ADS)

    Pec, Michał; Bujacz, Michał; Strumiłło, Paweł

    2008-01-01

    The use of Head Related Transfer Functions (HRTFs) in audio processing is a popular method of obtaining spatialized sound. HRTFs describe disturbances caused in the sound wave by the human body, especially by head and the ear pinnae. Since these shapes are unique, HRTFs differ greatly from person to person. For this reason measurement of personalized HRTFs is justified. Measured HRTFs also need further processing to be utilized in a system producing spatialized sound. This paper describes a system designed for efficient collecting of Head Related Transfer Functions as well as the measurement, interpolation and verification procedures.

  6. The resolution capability of an irregularly sampled dataset: With application to Geosat altimeter data

    NASA Technical Reports Server (NTRS)

    Chelton, Dudley B.; Schlax, Michael G.

    1994-01-01

    A formalism is presented for determining the wavenumber-frequency transfer function associated with an irregularly sampled multidimensional dataset. This transfer function reveals the filtering characteristics and aliasing patterns inherent in the sample design. In combination with information about the spectral characteristics of the signal, the transfer function can be used to quantify the spatial and temporal resolution capability of the dataset. Application of the method to idealized Geosat altimeter data (i.e., neglecting measurement errors and data dropouts) concludes that the Geosat orbit configuration is capable of resolving scales of about 3 deg in latitude and longitude by about 30 days.

  7. Photoinduced charge-transfer electronic excitation of tetracyanoethylene/tetramethylethylene complex in dichloromethane

    NASA Astrophysics Data System (ADS)

    Xu, Long-Kun; Bi, Ting-Jun; Ming, Mei-Jun; Wang, Jing-Bo; Li, Xiang-Yuan

    2017-07-01

    Based on the previous work on nonequilibrium solvation model by the authors, Intermolecular charge-transfer electronic excitation of tetracyanoethylene (TCE)/tetramethylethylene (TME) π -stacked complex in dichloromethane (DCM) has been investigated. For weak interaction correction, dispersion corrected functional DFT-D3 is adopted for geometry optimization. In order to identify the excitation metric, dipole moment components of each Cartesian direction, atomic charge, charge separation and Δr index are analyzed for TCE/TME complex. Calculation shows that the calculated excitation energy is dependent on the functional choice, when conjuncted with suitable time-dependent density functional, the modified nonequilibrium expression gives satisfied results for intermolecular charge-transfer electronic excitation.

  8. Transfer function analysis of the autonomic response to respiratory activity during random interval breathing

    NASA Technical Reports Server (NTRS)

    Chen, M. H.; Berger, R. D.; Saul, J. P.; Stevenson, K.; Cohen, R. J.

    1987-01-01

    We report a new method for the noninvasive characterization of the frequency response of the autonomic nervous system (ANS) in mediating fluctuations in heart rate (HR). The approach entails computation of the transfer function magnitude and phase between instantaneous lung volume and HR. Broad band fluctuations in lung volume were initiated when subjects breathed on cue to a sequence of beeps spaced randomly in time. We studied 10 subjects in both supine and standing positions. The transfer function, averaged among all the subjects, showed systematic differences between the two postures, reflecting the differing frequency responses of the sympathetic and parasympathetic divisions of the ANS.

  9. Use of a corrugated beam pipe as a passive deflector for bunch length measurements

    NASA Astrophysics Data System (ADS)

    Seok, Jimin; Chung, Moses; Kang, Heung-Sik; Min, Chang-Ki; Na, Donghyun

    2018-02-01

    We report the experimental demonstration of bunch length measurements using a corrugated metallic beam pipe as a passive deflector. The corrugated beam pipe has been adopted for reducing longitudinal chirping after the bunch compressors in several XFEL facilities worldwide. In the meantime, there have been attempts to measure the electron bunch's longitudinal current profile using the dipole wakefields generated in the corrugated pipe. Nevertheless, the bunch shape reconstructed from the nonlinearly deflected beam suffers from significant distortion, particularly near the head of the bunch. In this paper, we introduce an iterative process to improve the resolution of the bunch shape reconstruction. The astra and elegant simulations have been performed for pencil beam and cigar beam cases, in order to verify the effectiveness of the reconstruction process. To overcome the undesirable effects of transverse beam spreads, a measurement scheme involving both the corrugated beam pipe and the spectrometer magnet has been employed, both of which do not require a dedicated (and likely very expensive) rf system. A proof-of-principle experiment was carried out at Pohang Accelerator Laboratory (PAL) Injector Test Facility (ITF), and its results are discussed together with a comparison with the rf deflector measurement.

  10. Transfer functions of double- and multiple-cavity Fabry-Perot filters driven by Lorentzian sources.

    PubMed

    Marti, J; Capmany, J

    1996-12-20

    We derive expressions for the transfer functions of double- and multiple-cavity Fabry-Perot filters driven by laser sources with Lorentzian spectrum. These are of interest because of their applications in sensing and channel filtering in optical frequency-division multiplexing networks.

  11. Transfer functions of double- and multiple-cavity Fabry Perot filters driven by Lorentzian sources

    NASA Astrophysics Data System (ADS)

    Marti, Javier; Capmany, Jose

    1996-12-01

    We derive expressions for the transfer functions of double- and multiple-cavity Fabry Perot filters driven by laser sources with Lorentzian spectrum. These are of interest because of their applications in sensing and channel filtering in optical frequency-division multiplexing networks.

  12. Evaluation of Contact Heat Transfer Coefficient and Phase Transformation during Hot Stamping of a Hat-Type Part

    PubMed Central

    Kim, Heung-Kyu; Lee, Seong Hyeon; Choi, Hyunjoo

    2015-01-01

    Using an inverse analysis technique, the heat transfer coefficient on the die-workpiece contact surface of a hot stamping process was evaluated as a power law function of contact pressure. This evaluation was to determine whether the heat transfer coefficient on the contact surface could be used for finite element analysis of the entire hot stamping process. By comparing results of the finite element analysis and experimental measurements of the phase transformation, an evaluation was performed to determine whether the obtained heat transfer coefficient function could provide reasonable finite element prediction for workpiece properties affected by the hot stamping process. PMID:28788046

  13. Transfer of Learning Relates to Intrinsic Connectivity between Hippocampus, Ventromedial Prefrontal Cortex, and Large-Scale Networks

    PubMed Central

    Gerraty, Raphael T.; Davidow, Juliet Y.; Wimmer, G. Elliott; Kahn, Itamar

    2014-01-01

    An important aspect of adaptive learning is the ability to flexibly use past experiences to guide new decisions. When facing a new decision, some people automatically leverage previously learned associations, while others do not. This variability in transfer of learning across individuals has been demonstrated repeatedly and has important implications for understanding adaptive behavior, yet the source of these individual differences remains poorly understood. In particular, it is unknown why such variability in transfer emerges even among homogeneous groups of young healthy participants who do not vary on other learning-related measures. Here we hypothesized that individual differences in the transfer of learning could be related to relatively stable differences in intrinsic brain connectivity, which could constrain how individuals learn. To test this, we obtained a behavioral measure of memory-based transfer outside of the scanner and on a separate day acquired resting-state functional MRI images in 42 participants. We then analyzed connectivity across independent component analysis-derived brain networks during rest, and tested whether intrinsic connectivity in learning-related networks was associated with transfer. We found that individual differences in transfer were related to intrinsic connectivity between the hippocampus and the ventromedial prefrontal cortex, and between these regions and large-scale functional brain networks. Together, the findings demonstrate a novel role for intrinsic brain dynamics in flexible learning-guided behavior, both within a set of functionally specific regions known to be important for learning, as well as between these regions and the default and frontoparietal networks, which are thought to serve more general cognitive functions. PMID:25143610

  14. Improving Articulation and Transfer Relationships. New Directions for Community Colleges, Number 39.

    ERIC Educational Resources Information Center

    Kintzer, Frederick C., Ed.

    1982-01-01

    With the intent of revitalizing the study of educational articulation and transfer, this collection of essays describes and assesses the current status of transfer education, points to particular problems and concerns, and highlights specific techniques, activities, and practices. The volume includes "The Transfer Function--One of Many,"…

  15. The President's Pet: Transfer-Related Activities and Attitudes at Cerritos College.

    ERIC Educational Resources Information Center

    Cohen, Arthur M.; Brawer, Florence B.

    The Center for the Study for Community Colleges has examined community colleges in terms of the transfer function for over two decades, initiating the Transfer Assembly project in 1989 to collect hard, comparative data on transfer outcomes. In fall 1995, California's Cerritos College approached the Center for assistance in increasing its transfer…

  16. Assessing the California Transfer Function: The Transfer Rate and Its Measurement. Conclusions of the Data Needs Task Force.

    ERIC Educational Resources Information Center

    Intersegmental Coordinating Council, Sacramento, CA.

    In the fall of 1989, the Intersegmental Coordinating Council organized the Data Needs Task Force (DNTF) to determine the feasibility of establishing a transfer rate definition. Specifically, the DNTF was charged with defining the information needed to strengthen intersegmental transfer programs, establishing common definitions (including…

  17. Wireless power transfer inspired by the modern trends in electromagnetics

    NASA Astrophysics Data System (ADS)

    Song, Mingzhao; Belov, Pavel; Kapitanova, Polina

    2017-06-01

    Since the beginning of the 20th century, researchers have been looking for an effective way to transfer power without wired connections, but the wireless power transfer technology started to attract extensive interest from the industry side only in 2007 when the first smartphone was released and a consumer electronics revolution was triggered. Currently, the modern technology of wireless power transfer already has a rich research and development history as well as outstanding advances in commercialization. This review is focused on the description of distinctive implementations of this technology inspired by the modern trends in electrodynamics. We compare the performances of the power transfer systems based on three kinds of resonators, i.e., metallic coil resonators, dielectric resonators, and cavity mode resonators. We argue that metamaterials and meta-atoms are powerful tools to improve the functionalities and to obtain novel properties of the systems. We review different approaches to enhance the functionality of the wireless power transfer systems including control of the power transfer path and increase of the operation range and efficiency. Various applications of wireless power transfer are discussed and currently available standards are reviewed.

  18. Coupled sensitizer-catalyst dyads: electron-transfer reactions in a perylene-polyoxometalate conjugate.

    PubMed

    Odobel, Fabrice; Séverac, Marjorie; Pellegrin, Yann; Blart, Errol; Fosse, Céline; Cannizzo, Caroline; Mayer, Cédric R; Elliott, Kristopher J; Harriman, Anthony

    2009-01-01

    Ultrafast discharge of a single-electron capacitor: A variety of intramolecular electron-transfer reactions are apparent for polyoxometalates functionalized with covalently attached perylene monoimide chromophores, but these are restricted to single-electron events. (et=electron transfer, cr=charge recombination, csr=charge-shift reaction, PER=perylene, POM=polyoxometalate).A new strategy is introduced that permits covalent attachment of an organic chromophore to a polyoxometalate (POM) cluster. Two examples are reported that differ according to the nature of the anchoring group and the flexibility of the linker. Both POMs are functionalized with perylene monoimide units, which function as photon collectors and form a relatively long-lived charge-transfer state under illumination. They are reduced to a stable pi-radical anion by electrolysis or to a protonated dianion under photolysis in the presence of aqueous triethanolamine. The presence of the POM opens up an intramolecular electron-transfer route by which the charge-transfer state reduces the POM. The rate of this process depends on the molecular conformation and appears to involve through-space interactions. Prior reduction of the POM leads to efficient fluorescence quenching, again due to intramolecular electron transfer. In most cases, it is difficult to resolve the electron-transfer products because of relatively fast reverse charge shift that occurs within a closed conformer. Although the POM can store multiple electrons, it has not proved possible to use these systems as molecular-scale capacitors because of efficient electron transfer from the one-electron-reduced POM to the excited singlet state of the perylene monoimide.

  19. Compaction-Based Deformable Terrain Model as an Interface for Real-Time Vehicle Dynamics Simulations

    DTIC Science & Technology

    2013-04-16

    to vehicular loads, and the resulting visco-elastic-plastic stress/strain on the affected soil volume. Pedo transfer functions allow for the...resulting visco-elastic-plastic stress/strain on the affected soil volume. Pedo transfer functions allow for the calculation of the soil mechanics model

  20. Back-illuminated CCD imager adapted for contrast transfer function measurements thereon

    NASA Technical Reports Server (NTRS)

    Levine, Peter A. (Inventor)

    1987-01-01

    Stripe patterns of varying spatial frequency, formed in the top-metalization of a back-illuminated solid-state imager, facilitate on-line measurement of contrast transfer function during wafer-probe testing. The imager may be packaged to allow front-illumination during in-the-field testing after its manufacture.

  1. 16 CFR 1750.2 - Transfer of functions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION REFRIGERATOR SAFETY ACT REGULATIONS STANDARD FOR DEVICES TO PERMIT THE OPENING OF HOUSEHOLD REFRIGERATOR DOORS FROM THE INSIDE § 1750.2 Transfer of functions. Effective May 14, 1973, section 30(c) of the Consumer Product Safety Act (86 Stat. 1231; 15 U.S.C...

  2. 16 CFR § 1750.2 - Transfer of functions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...§ 1750.2 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION REFRIGERATOR SAFETY ACT REGULATIONS STANDARD FOR DEVICES TO PERMIT THE OPENING OF HOUSEHOLD REFRIGERATOR DOORS FROM THE INSIDE § 1750.2 Transfer of functions. Effective May 14, 1973, section 30(c) of the Consumer Product Safety Act (86 Stat...

  3. 16 CFR 1750.2 - Transfer of functions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION REFRIGERATOR SAFETY ACT REGULATIONS STANDARD FOR DEVICES TO PERMIT THE OPENING OF HOUSEHOLD REFRIGERATOR DOORS FROM THE INSIDE § 1750.2 Transfer of functions. Effective May 14, 1973, section 30(c) of the Consumer Product Safety Act (86 Stat. 1231; 15 U.S.C...

  4. 16 CFR 1750.2 - Transfer of functions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION REFRIGERATOR SAFETY ACT REGULATIONS STANDARD FOR DEVICES TO PERMIT THE OPENING OF HOUSEHOLD REFRIGERATOR DOORS FROM THE INSIDE § 1750.2 Transfer of functions. Effective May 14, 1973, section 30(c) of the Consumer Product Safety Act (86 Stat. 1231; 15 U.S.C...

  5. 16 CFR 1750.2 - Transfer of functions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION REFRIGERATOR SAFETY ACT REGULATIONS STANDARD FOR DEVICES TO PERMIT THE OPENING OF HOUSEHOLD REFRIGERATOR DOORS FROM THE INSIDE § 1750.2 Transfer of functions. Effective May 14, 1973, section 30(c) of the Consumer Product Safety Act (86 Stat. 1231; 15 U.S.C...

  6. Energy Transfer and a Recurring Mathematical Function

    ERIC Educational Resources Information Center

    Atkin, Keith

    2013-01-01

    This paper extends the interesting work of a previous contributor concerning the analogies between physical phenomena such as mechanical collisions and the transfer of power in an electric circuit. Emphasis is placed on a mathematical function linking these different areas of physics. This unifying principle is seen as an exciting opportunity to…

  7. Track/train dynamics test procedure transfer function test

    NASA Technical Reports Server (NTRS)

    Vigil, R. A.

    1975-01-01

    A transfer function vibration test was made on an 80 ton open hopper freight car in an effort to obtain validation data on the car's nonlinear elastic model. Test configuration, handling, test facilities, test operations, and data acquisition/reduction activities necessary to meet the conditions of test requirements are given.

  8. Distal Nerve Transfer: Perspective of Reconstructive Microsurgery.

    PubMed

    Doi, Kazuteru

    2018-04-01

    Recent articles have strongly emphasized the superiority of distal nerve transfers despite indefinite assessment. I would like to introduce the problems associated with functional evaluation following nerve transfers. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  9. Extracellular vesicle-mediated transfer of donor genomic DNA to recipient cells is a novel mechanism for genetic influence between cells

    PubMed Central

    Cai, Jin; Han, Yu; Ren, Hongmei; Chen, Caiyu; He, Duofen; Zhou, Lin; Eisner, Gilbert M.; Asico, Laureano D.; Jose, Pedro A.; Zeng, Chunyu

    2013-01-01

    Extracellular vesicles (EVs) carry signals within or at their limiting membranes, providing a mechanism by which cells can exchange more complex information than what was previously thought. In addition to mRNAs and microRNAs, there are DNA fragments in EVs. Solexa sequencing indicated the presence of at least 16434 genomic DNA (gDNA) fragments in the EVs from human plasma. Immunofluorescence study showed direct evidence that acridine orange-stained EV DNAs could be transferred into the cells and localize to and inside the nuclear membrane. However, whether the transferred EV DNAs are functional or not is not clear. We found that EV gDNAs could be homologously or heterologously transferred from donor cells to recipient cells, and increase gDNA-coding mRNA, protein expression, and function (e.g. AT1 receptor). An endogenous promoter of the AT1 receptor, NF-κB, could be recruited to the transferred DNAs in the nucleus, and increase the transcription of AT1 receptor in the recipient cells. Moreover, the transferred EV gDNAs have pathophysiological significance. BCR/ABL hybrid gene, involved in the pathogenesis of chronic myeloid leukemia, could be transferred from K562 EVs to HEK293 cells or neutrophils. Our present study shows that the gDNAs transferred from EVs to cells have physiological significance, not only to increase the gDNA-coding mRNA and protein levels, but also to influence function in recipient cells. PMID:23580760

  10. Arterial pressure transfer characteristics: effects of travel time.

    PubMed

    Westerhof, Berend E; Guelen, Ilja; Stok, Wim J; Wesseling, Karel H; Spaan, Jos A E; Westerhof, Nico; Bos, Willem Jan; Stergiopulos, Nikos

    2007-02-01

    We investigated the quantitative contribution of all local conduit arterial, blood, and distal load properties to the pressure transfer function from brachial artery to aorta. The model was based on anatomical data, Young's modulus, wall viscosity, blood viscosity, and blood density. A three-element windkessel represented the distal arterial tree. Sensitivity analysis was performed in terms of frequency and magnitude of the peak of the transfer function and in terms of systolic, diastolic, and pulse pressure in the aorta. The root mean square error (RMSE) described the accuracy in wave-shape prediction. The percent change of these variables for a 25% alteration of each of the model parameters was calculated. Vessel length and diameter are found to be the most important parameters determining pressure transfer. Systolic and diastolic pressure changed <3% and RMSE <1.8 mmHg for a 25% change in vessel length and diameter. To investigate how arterial tapering influences the pressure transfer, a single uniform lossless tube was modeled. This simplification introduced only small errors in systolic and diastolic pressures (1% and 0%, respectively), and wave shape was less well described (RMSE, approximately 2.1 mmHg). Local (arm) vasodilation affects the transfer function little, because it has limited effect on the reflection coefficient. Since vessel length and diameter translate into travel time, this parameter can describe the transfer accurately. We suggest that with a, preferably, noninvasively measured travel time, an accurate individualized description of pressure transfer can be obtained.

  11. Preserving transfer independence among individuals with spinal cord injury.

    PubMed

    Nyland, J; Quigley, P; Huang, C; Lloyd, J; Harrow, J; Nelson, A

    2000-11-01

    Literature review. Upper extremity (UE) joint degeneration, particularly at the shoulder, detrimentally influences functional independence, quality of life, cardiovascular disease risk, and life expectancy of individuals following spinal cord injury (SCI). This review (1) describes UE use for transfers among individuals with SCI; (2) describes contributing factors associated with UE joint degeneration and loss of transfer independence; (3) summarizes and identifies gaps in existing research; and (4) provides suggestions for future research. Investigations of wheelchair transfer related UE joint and function preservation among individuals with SCI should consider factors including age and length of time from SCI onset, interface between subject-wheelchair, pain, shoulder joint range of motion (ROM) and muscle strength deficiencies or imbalances, exercise capacity and tolerance for the physical strain of activities of daily living (ADL), body mass and composition, previous UE injury or disease history, and transfer techniques. Existing studies of transfers among individuals with SCI have relied on small groups of either asymptomatic or non-impaired subjects, with minimal integration of kinematic, kinetic and electromyographic data. Descriptions of UE joint ROM, forces, and moments produced during transfers are lacking. Biomechanical measurement and computer modeling have provided increasingly accurate tools for acquiring the data needed to guide intervention planning to prevent UE joint degeneration and preserve function among individuals with SCI. The identification of stressful sub-components during transfers will enable intervening clinicians and engineers who design and modify assistive and adaptive devices to better serve individuals with SCI.

  12. Estimating contrast transfer function and associated parameters by constrained non-linear optimization.

    PubMed

    Yang, C; Jiang, W; Chen, D-H; Adiga, U; Ng, E G; Chiu, W

    2009-03-01

    The three-dimensional reconstruction of macromolecules from two-dimensional single-particle electron images requires determination and correction of the contrast transfer function (CTF) and envelope function. A computational algorithm based on constrained non-linear optimization is developed to estimate the essential parameters in the CTF and envelope function model simultaneously and automatically. The application of this estimation method is demonstrated with focal series images of amorphous carbon film as well as images of ice-embedded icosahedral virus particles suspended across holes.

  13. Analysis and calculation of lightning-induced voltages in aircraft electrical circuits

    NASA Technical Reports Server (NTRS)

    Plumer, J. A.

    1974-01-01

    Techniques to calculate the transfer functions relating lightning-induced voltages in aircraft electrical circuits to aircraft physical characteristics and lightning current parameters are discussed. The analytical work was carried out concurrently with an experimental program of measurements of lightning-induced voltages in the electrical circuits of an F89-J aircraft. A computer program, ETCAL, developed earlier to calculate resistive and inductive transfer functions is refined to account for skin effect, providing results more valid over a wider range of lightning waveshapes than formerly possible. A computer program, WING, is derived to calculate the resistive and inductive transfer functions between a basic aircraft wing and a circuit conductor inside it. Good agreement is obtained between transfer inductances calculated by WING and those reduced from measured data by ETCAL. This computer program shows promise of expansion to permit eventual calculation of potential lightning-induced voltages in electrical circuits of complete aircraft in the design stage.

  14. Persistence, immune specificity, and functional ability of murine mutant ras epitope-specific CD4(+) and CD8(+) T lymphocytes following in vivo adoptive transfer.

    PubMed

    Bristol, J A; Schlom, J; Abrams, S I

    1999-05-25

    Adoptive T-cell transfer has been shown to be a potentially effective strategy for cellular immunotherapy in some murine models of disease. However, several issues remain unresolved regarding some of the basic features involved in effective adoptive transfer, such as the influence of specific peptide antigen (Ag) boost after T-cell transfer, the addition of IL-2 post-T-cell transfer, the trafficking of transferred T cells to lymphoid and nonlymphoid tissues, and the functional stability of recoverable CD4(+) and CD8(+) T cells. We investigated several of these parameters, particularly as they relate to the persistence and maintenance of effector functions of murine CD4(+) and/or CD8(+) T lymphocytes after adoptive cellular transfer into partially gamma-irradiated syngeneic hosts. Our laboratory previously identified murine (H-2(d)) immunogenic CD4(+) and CD8(+) T-cell peptide epitopes reflecting codon 12 ras mutations as tumor-specific Ag. Therefore, the model system chosen here employed epitope-specific MHC class II-restricted CD4(+) T cells and MHC class I-restricted CD8(+) T cells produced from previously immunized BALB/c mice. Between 2 and 7 days after T-cell transfer, recipient mice received various combinations of peptide boosts and/or IL-2 treatments. At different times after the T-cell transfer, spleen and lung tissues were analyzed phenotypically to monitor the persistence of the immune T cells and functionally (via proliferation or cytotoxicity assays) to assess the maintenance of peptide specificity. The results showed that immune donor T lymphocytes (uncultured immune T cells or cloned T cells) were recoverable from the spleens and lungs of recipient mice after transfer. The recovery of Ag-specific T-cell responses was greatest from recipient mice that received peptide boosts and IL-2 treatment. However, mice that received a peptide boost without IL-2 treatment responded nearly as well, which suggested that including a peptide boost after T-cell transfer was more obligatory than exogenous IL-2 treatment to sustain adoptively transferred T cells in vivo. Ag-specific T-cell responses were weak in mice that either received IL-2 alone or did not receive the cognate peptide boost after T-cell transfer. The T-cell clones were also monitored by flow cytometry or RT-PCR based on expression of the T-cell receptor Vbeta-chain, which was previously characterized. Ag-specific T cells were recovered from both spleens and lungs of recipient mice, demonstrating that the T-cell clones could localize to both lymphoid and nonlymphoid tissues. This study demonstrates that both uncultured and in vitro-cloned T lymphocytes can migrate to lymphoid tissues and nonlymphoid (e.g., lung) tissues in recipient hosts and that their functional activities can be maintained at these sites after transfer, if they are exposed to peptide Ag in vivo. Copyright 1999 Academic Press.

  15. Exact finite elements for conduction and convection

    NASA Technical Reports Server (NTRS)

    Thornton, E. A.; Dechaumphai, P.; Tamma, K. K.

    1981-01-01

    An approach for developing exact one dimensional conduction-convection finite elements is presented. Exact interpolation functions are derived based on solutions to the governing differential equations by employing a nodeless parameter. Exact interpolation functions are presented for combined heat transfer in several solids of different shapes, and for combined heat transfer in a flow passage. Numerical results demonstrate that exact one dimensional elements offer advantages over elements based on approximate interpolation functions.

  16. [Microsurgical 2nd toe transfer for catastrophic hand reconstruction].

    PubMed

    Placer, A; Lozano, Ja

    2007-01-01

    The correct reconstruction of the catastrophic hand requires complex surgical techniques. The microsurgical transference of a toe is indicated when all other reconstructive options are shown to be useless for the reconstruction of the required clamp function. In this clinical note we set out the case of a 32 year old man, who came to our accident and emergency department after suffering a traffic accident. After exploration the diagnosis was that of catastrophic left hand, among other policontusions. Urgent surgery was carried out, saving the maximum possible viable structures. The immediate result of this surgery was a hand with 1st, 4th and 5th functional fingers. As the essential clamp function between the 1st and 4th or 5th fingers was not totally satisfactory, we decided to reconstruct the 3rd finger of his hand with his ipsilateral 2nd toe. All pertinent studies to determine vascularisation of the flap were carried out in planning the surgery, and the microsurgical transfer was then realized, which was successful. Today, after a suitable rehabilitation, the patient has recovered a satisfactory function of heavy and fine clamp in the operated hand. Toe to hand transfer is a good option for finger reconstruction and its function. Rehabilitation is the key to functional recovery.

  17. Effects of cannabis on lung function: a population-based cohort study.

    PubMed

    Hancox, R J; Poulton, R; Ely, M; Welch, D; Taylor, D R; McLachlan, C R; Greene, J M; Moffitt, T E; Caspi, A; Sears, M R

    2010-01-01

    The effects of cannabis on lung function remain unclear and may be different from those of tobacco. We compared the associations between use of these substances and lung function in a population-based cohort (n = 1,037). Cannabis and tobacco use were reported at ages 18, 21, 26 and 32 yrs. Spirometry, plethysmography and carbon monoxide transfer factor were measured at 32 yrs. Associations between lung function and exposure to each substance were adjusted for exposure to the other substance. Cumulative cannabis use was associated with higher forced vital capacity, total lung capacity, functional residual capacity and residual volume. Cannabis was also associated with higher airway resistance but not with forced expiratory volume in 1 s, forced expiratory ratio or transfer factor. These findings were similar among those who did not smoke tobacco. In contrast, tobacco use was associated with lower forced expiratory volume in 1 s, lower forced expiratory ratio, lower transfer factor and higher static lung volumes, but not with airway resistance. Cannabis appears to have different effects on lung function from those of tobacco. Cannabis use was associated with higher lung volumes, suggesting hyperinflation and increased large-airways resistance, but there was little evidence for airflow obstruction or impairment of gas transfer.

  18. Testing the Kerr Black Hole Hypothesis Using X-Ray Reflection Spectroscopy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bambi, Cosimo; Nampalliwar, Sourabh; Cárdenas-Avendaño, Alejandro

    We present the first X-ray reflection model for testing the assumption that the metric of astrophysical black holes is described by the Kerr solution. We employ the formalism of the transfer function proposed by Cunningham. The calculations of the reflection spectrum of a thin accretion disk are split into two parts: the calculation of the transfer function and the calculation of the local spectrum at any emission point in the disk. The transfer function only depends on the background metric and takes into account all the relativistic effects (gravitational redshift, Doppler boosting, and light bending). Our code computes the transfermore » function for a spacetime described by the Johannsen metric and can easily be extended to any stationary, axisymmetric, and asymptotically flat spacetime. Transfer functions and single line shapes in the Kerr metric are compared to those calculated from existing codes to check that we reach the necessary accuracy. We also simulate some observations with NuSTAR and LAD/eXTP and fit the data with our new model to show the potential capabilities of current and future observations to constrain possible deviations from the Kerr metric.« less

  19. A review of the source and function of microbiota in breast milk.

    PubMed

    Latuga, M Susan; Stuebe, Alison; Seed, Patrick C

    2014-01-01

    Breast milk contains a rich microbiota composed of viable skin and non-skin bacteria. The extent of the breast milk microbiota diversity has been revealed through new culture-independent studies using microbial DNA signatures. However, the extent to which the breast milk microbiota are transferred from mother to infant and the function of these breast milk microbiota for the infant are only partially understood. Here, we appraise hypotheses regarding the formation of breast milk microbiota, including retrograde infant-to-mother transfer and enteromammary trafficking, and we review current knowledge of mechanisms determining the extent of breast milk microbiota transfer from mother to infant. We highlight known functions of constituents in the breast milk microbiota-to enhance immunity, liberate nutrients, synergize with breast milk oligosaccharides to enhance intestinal barrier function, and strengthen a functional gut-brain axis. We also consider the pathophysiology of maternal mastitis with respect to a dysbiosis or abnormal shift in the breast milk microbiota. In conclusion, through a complex, highly evolved process in the early stages of discovery, mothers transfer the breast milk microbiota to their infants to impact infant growth and development. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  20. Transfer function analysis of dynamic cerebral autoregulation in humans

    NASA Technical Reports Server (NTRS)

    Zhang, R.; Zuckerman, J. H.; Giller, C. A.; Levine, B. D.; Blomqvist, C. G. (Principal Investigator)

    1998-01-01

    To test the hypothesis that spontaneous changes in cerebral blood flow are primarily induced by changes in arterial pressure and that cerebral autoregulation is a frequency-dependent phenomenon, we measured mean arterial pressure in the finger and mean blood flow velocity in the middle cerebral artery (VMCA) during supine rest and acute hypotension induced by thigh cuff deflation in 10 healthy subjects. Transfer function gain, phase, and coherence function between changes in arterial pressure and VMCA were estimated using the Welch method. The impulse response function, calculated as the inverse Fourier transform of this transfer function, enabled the calculation of transient changes in VMCA during acute hypotension, which was compared with the directly measured change in VMCA during thigh cuff deflation. Beat-to-beat changes in VMCA occurred simultaneously with changes in arterial pressure, and the autospectrum of VMCA showed characteristics similar to arterial pressure. Transfer gain increased substantially with increasing frequency from 0.07 to 0.20 Hz in association with a gradual decrease in phase. The coherence function was > 0.5 in the frequency range of 0.07-0.30 Hz and < 0.5 at < 0.07 Hz. Furthermore, the predicted change in VMCA was similar to the measured VMCA during thigh cuff deflation. These data suggest that spontaneous changes in VMCA that occur at the frequency range of 0.07-0.30 Hz are related strongly to changes in arterial pressure and, furthermore, that short-term regulation of cerebral blood flow in response to changes in arterial pressure can be modeled by a transfer function with the quality of a high-pass filter in the frequency range of 0.07-0.30 Hz.

  1. Free Thyroid Transfer: A Novel Procedure to Prevent Radiation-induced Hypothyroidism

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Harris, Jeffrey; Almarzouki, Hani; Department of Otolaryngology-Head and Neck Surgery, King Abdulaziz University, Jeddah

    Purpose: The incidence of hypothyroidism after radiation therapy for head and neck cancer (HNC) has been found to be ≤53%. Medical treatment of hypothyroidism can be costly and difficult to titrate. The aim of the present study was to assess the feasibility of free thyroid transfer as a strategy for the prevention of radiation-induced damage to the thyroid gland during radiation therapy for HNC. Methods and Materials: A prospective feasibility study was performed involving 10 patients with a new diagnosis of advanced HNC undergoing ablative surgery, radial forearm free-tissue transfer reconstruction, and postoperative adjuvant radiation therapy. During the neck dissection,more » hemithyroid dissection was completed with preservation of the thyroid arterial and venous supply for implantation into the donor forearm site. All patients underwent a diagnostic thyroid technetium scan 6 weeks and 12 months postoperatively to examine the functional integrity of the transferred thyroid tissue. Results: Free thyroid transfer was executed in 9 of the 10 recruited patients with advanced HNC. The postoperative technetium scans demonstrated strong uptake of technetium at the forearm donor site at 6 weeks and 12 months for all 9 of the transplanted patients. Conclusions: The thyroid gland can be transferred as a microvascular free transfer with maintenance of function. This technique could represent a novel strategy for maintenance of thyroid function after head and neck irradiation.« less

  2. The transfer of Cfunc contextual control through equivalence relations.

    PubMed

    Perez, William F; Fidalgo, Adriana P; Kovac, Roberta; Nico, Yara C

    2015-05-01

    Derived relational responding is affected by contextual stimuli (Cfunc) that select specific stimulus functions. The present study investigated the transfer of Cfunc contextual control through equivalence relations by evaluating both (a) the maintenance of Cfunc contextual control after the expansion of a relational network, and (b) the establishment of novel contextual stimuli by the transfer of Cfunc contextual control through equivalence relations. Initially, equivalence relations were established and contingencies were arranged so that colors functioned as Cfunc stimuli controlling participants' key-pressing responses in the presence of any stimulus from a three-member equivalence network. To investigate the first research question, the three-member equivalence relations were expanded to five members and the novel members were presented with the Cfunc stimuli in the key-pressing task. To address the second goal of this study, the colors (Cfunc) were established as equivalent to certain line patterns. The transfer of contextual cue function (Cfunc) was tested replacing the colored backgrounds with line patterns in the key-pressing task. Results suggest that the Cfunc contextual control was transferred to novel stimuli that were added to the relational network. In addition, the line patterns indirectly acquired the contextual cue function (Cfunc) initially established for the colored backgrounds. The conceptual and applied implications of Cfunc contextual control are discussed. © Society for the Experimental Analysis of Behavior.

  3. Predator and prey biodiversity relationship and its consequences on marine ecosystem functioning-interplay between nanoflagellates and bacterioplankton.

    PubMed

    Yang, Jinny Wu; Wu, Wenxue; Chung, Chih-Ching; Chiang, Kuo-Ping; Gong, Gwo-Ching; Hsieh, Chih-Hao

    2018-06-01

    The importance of biodiversity effects on ecosystem functioning across trophic levels, especially via predatory-prey interactions, is receiving increased recognition. However, this topic has rarely been explored for marine microbes, even though microbial biodiversity contributes significantly to marine ecosystem function and energy flows. Here we examined diversity and biomass of bacteria (prey) and nanoflagellates (predators), as well as their effects on trophic transfer efficiency in the East China Sea. Specifically, we investigated: (i) predator diversity effects on prey biomass and trophic transfer efficiency (using the biomass ratio of predator/prey as a proxy), (ii) prey diversity effects on predator biomass and trophic transfer efficiency, and (iii) the relationship between predator and prey diversity. We found higher prey diversity enhanced both diversity and biomass of predators, as well as trophic transfer efficiency, which may arise from more balanced diet and/or enhanced niche complementarity owing to higher prey diversity. By contrast, no clear effect was detected for predator diversity on prey biomass and transfer efficiency. Notably, we found prey diversity effects on predator-prey interactions; whereas, we found no significant diversity effect on biomass within the same trophic level. Our findings highlight the importance of considering multi-trophic biodiversity effects on ecosystem functioning in natural ecosystems.

  4. A novel hybrid scattering order-dependent variance reduction method for Monte Carlo simulations of radiative transfer in cloudy atmosphere

    NASA Astrophysics Data System (ADS)

    Wang, Zhen; Cui, Shengcheng; Yang, Jun; Gao, Haiyang; Liu, Chao; Zhang, Zhibo

    2017-03-01

    We present a novel hybrid scattering order-dependent variance reduction method to accelerate the convergence rate in both forward and backward Monte Carlo radiative transfer simulations involving highly forward-peaked scattering phase function. This method is built upon a newly developed theoretical framework that not only unifies both forward and backward radiative transfer in scattering-order-dependent integral equation, but also generalizes the variance reduction formalism in a wide range of simulation scenarios. In previous studies, variance reduction is achieved either by using the scattering phase function forward truncation technique or the target directional importance sampling technique. Our method combines both of them. A novel feature of our method is that all the tuning parameters used for phase function truncation and importance sampling techniques at each order of scattering are automatically optimized by the scattering order-dependent numerical evaluation experiments. To make such experiments feasible, we present a new scattering order sampling algorithm by remodeling integral radiative transfer kernel for the phase function truncation method. The presented method has been implemented in our Multiple-Scaling-based Cloudy Atmospheric Radiative Transfer (MSCART) model for validation and evaluation. The main advantage of the method is that it greatly improves the trade-off between numerical efficiency and accuracy order by order.

  5. Framework for a ground-water quality monitoring and assessment program for California

    USGS Publications Warehouse

    Belitz, Kenneth; Dubrovsky, Neil M.; Burow, Karen; Jurgens, Bryant C.; John, Tyler

    2003-01-01

    The State of California uses more ground water than any other State in the Nation. With a population of over 30 million people, an agricultural economy based on intensive irrigation, large urban industrial areas, and naturally elevated concentrations of some trace elements, there is a wide range of contaminant sources that have the potential to contaminate ground water and limit its beneficial uses. In response to the many-and different-potential sources of ground-water contamination, the State of California has evolved an extensive set of rules and programs to protect ground-water quality, and agencies to implement the rules and programs. These programs have in common a focus on compliance with regulations governing chemical use and (or) ground-water quality. Although appropriate for, and successful at, their specific missions, these programs do not at present provide a comprehensive view of ground-water quality in the State of California. In October 2001, The California Assembly passed a bill, AB 599, establishing the Ground-Water- Quality Monitoring Act of 2001.' The goal of AB 599 is to improve Statewide comprehensive ground-water monitoring and increase availability of information about ground-water quality to the public. AB 599 requires the State Water Resources Control Board (SWRCB), in collaboration with an interagency task force (ITF) and a public advisory committee (PAC), to develop a plan for a comprehensive ground-water monitoring program. AB 599 specifies that the comprehensive program should be capable of assessing each ground-water basin in the State through direct and other statistically reliable sampling approaches, and that the program should integrate existing monitoring programs and design new program elements, as necessary. AB 599 also stresses the importance of prioritizing ground-water basins that provide drinking water. The United States Geological Survey (USGS), in cooperation with the SWRCB, and in coordination with the ITF and PAC, has developed a framework for a comprehensive ground-water-quality monitoring and assessment program for California. The proposed framework relies extensively on previous work conducted by the USGS through its National Water-Quality Assessment (NAWQA) program. In particular, the NAWQA program defines three types of ground-water assessment: (1) status, the assessment of the current quality of the ground-water resource; (2) trends, the detection of changes in water quality, and (3) understanding, assessing the human and natural factors that affect ground-water quality. A Statewide, comprehensive ground-water quality-monitoring and assessment program is most efficiently accomplished by applying uniform and consistent study-design and data-collection protocols to the entire State. At the same time, a comprehensive program should be relevant at a variety of scales, and therefore needs to retain flexibility to address regional and local issues. Consequently, many of the program components include a predominant element that will be consistently applied in all basins, and a secondary element that may be applied in specific basins where local conditions warrant attention.

  6. A Wireless Interface for Replacing the Cables in Bridge-Sensor Applications

    PubMed Central

    Pavlin, Marko; Novak, Franc

    2012-01-01

    This paper presents a solution in which a wireless interface is employed to replace the cables in bridge-sensor measurement applications. The most noticeable feature of the presented approach is the fact that the wireless interface simply replaces the cables without any additional hardware modification to the existing system. In this approach, the concept of reciprocal topology is employed, where the transmitter side acquires signals with its own transfer function and the receiver side reconstructs them with the transfer function reciprocal to the transmitter transfer function. In this paper the principle of data acquisition and reconstruction is described together with the implementation details of the signal transfer from the sensor to the signal-monitoring equipment. The wireless data communication was investigated and proprietary data-reduction methods were developed. The proposed methods and algorithms were implemented using two different wireless technologies. The performance was evaluated with a dedicated data-acquisition system and finally, the test results were analyzed. The two different sets of results indicated the high level of amplitude and the temporal accuracy of the wirelessly transferred sensor signals. PMID:23112585

  7. Modelling charge transfer reactions with the frozen density embedding formalism.

    PubMed

    Pavanello, Michele; Neugebauer, Johannes

    2011-12-21

    The frozen density embedding (FDE) subsystem formulation of density-functional theory is a useful tool for studying charge transfer reactions. In this work charge-localized, diabatic states are generated directly with FDE and used to calculate electronic couplings of hole transfer reactions in two π-stacked nucleobase dimers of B-DNA: 5'-GG-3' and 5'-GT-3'. The calculations rely on two assumptions: the two-state model, and a small differential overlap between donor and acceptor subsystem densities. The resulting electronic couplings agree well with benchmark values for those exchange-correlation functionals that contain a high percentage of exact exchange. Instead, when semilocal GGA functionals are used the electronic couplings are grossly overestimated.

  8. Cumulants of heat transfer across nonlinear quantum systems

    NASA Astrophysics Data System (ADS)

    Li, Huanan; Agarwalla, Bijay Kumar; Li, Baowen; Wang, Jian-Sheng

    2013-12-01

    We consider thermal conduction across a general nonlinear phononic junction. Based on two-time observation protocol and the nonequilibrium Green's function method, heat transfer in steady-state regimes is studied, and practical formulas for the calculation of the cumulant generating function are obtained. As an application, the general formalism is used to study anharmonic effects on fluctuation of steady-state heat transfer across a single-site junction with a quartic nonlinear on-site pinning potential. An explicit nonlinear modification to the cumulant generating function exact up to the first order is given, in which the Gallavotti-Cohen fluctuation symmetry is found still valid. Numerically a self-consistent procedure is introduced, which works well for strong nonlinearity.

  9. Multi-channel spatialization systems for audio signals

    NASA Technical Reports Server (NTRS)

    Begault, Durand R. (Inventor)

    1993-01-01

    Synthetic head related transfer functions (HRTF's) for imposing reprogrammable spatial cues to a plurality of audio input signals included, for example, in multiple narrow-band audio communications signals received simultaneously are generated and stored in interchangeable programmable read only memories (PROM's) which store both head related transfer function impulse response data and source positional information for a plurality of desired virtual source locations. The analog inputs of the audio signals are filtered and converted to digital signals from which synthetic head related transfer functions are generated in the form of linear phase finite impulse response filters. The outputs of the impulse response filters are subsequently reconverted to analog signals, filtered, mixed, and fed to a pair of headphones.

  10. Multi-channel spatialization system for audio signals

    NASA Technical Reports Server (NTRS)

    Begault, Durand R. (Inventor)

    1995-01-01

    Synthetic head related transfer functions (HRTF's) for imposing reprogramable spatial cues to a plurality of audio input signals included, for example, in multiple narrow-band audio communications signals received simultaneously are generated and stored in interchangeable programmable read only memories (PROM's) which store both head related transfer function impulse response data and source positional information for a plurality of desired virtual source locations. The analog inputs of the audio signals are filtered and converted to digital signals from which synthetic head related transfer functions are generated in the form of linear phase finite impulse response filters. The outputs of the impulse response filters are subsequently reconverted to analog signals, filtered, mixed and fed to a pair of headphones.

  11. Order reduction of z-transfer functions via multipoint Jordan continued-fraction expansion

    NASA Technical Reports Server (NTRS)

    Lee, Ying-Chin; Hwang, Chyi; Shieh, Leang S.

    1992-01-01

    The order reduction problem of z-transfer functions is solved by using the multipoint Jordan continued-fraction expansion (MJCFE) technique. An efficient algorithm that does not require the use of complex algebra is presented for obtaining an MJCFE from a stable z-transfer function with expansion points selected from the unit circle and/or the positive real axis of the z-plane. The reduced-order models are exactly the multipoint Pade approximants of the original system and, therefore, they match the (weighted) time-moments of the impulse response and preserve the frequency responses of the system at some characteristic frequencies, such as gain crossover frequency, phase crossover frequency, bandwidth, etc.

  12. Modeling and control of flexible space structures

    NASA Technical Reports Server (NTRS)

    Wie, B.; Bryson, A. E., Jr.

    1981-01-01

    The effects of actuator and sensor locations on transfer function zeros are investigated, using uniform bars and beams as generic models of flexible space structures. It is shown how finite element codes may be used directly to calculate transfer function zeros. The impulse response predicted by finite-dimensional models is compared with the exact impulse response predicted by the infinite dimensional models. It is shown that some flexible structures behave as if there were a direct transmission between actuator and sensor (equal numbers of zeros and poles in the transfer function). Finally, natural damping models for a vibrating beam are investigated since natural damping has a strong influence on the appropriate active control logic for a flexible structure.

  13. Determination of lateral-stability derivatives and transfer-function coefficients from frequency-response data for lateral motions

    NASA Technical Reports Server (NTRS)

    Donegan, James J; Robinson, Samuel W , Jr; Gates, Ordway, B , jr

    1955-01-01

    A method is presented for determining the lateral-stability derivatives, transfer-function coefficients, and the modes for lateral motion from frequency-response data for a rigid aircraft. The method is based on the application of the vector technique to the equations of lateral motion, so that the three equations of lateral motion can be separated into six equations. The method of least squares is then applied to the data for each of these equations to yield the coefficients of the equations of lateral motion from which the lateral-stability derivatives and lateral transfer-function coefficients are computed. Two numerical examples are given to demonstrate the use of the method.

  14. Measuring surgeons' treatment preferences and satisfaction with nerve reconstruction techniques for children with unique brachial plexus birth palsies.

    PubMed

    Shah, Amee K; Zurakowski, David; Jessel, Rebecca H; Kuo, Anne; Waters, Peter M

    2006-09-15

    This study surveyed microsurgeons on treatments chosen for infants with brachial plexus birth palsies who have had failure of antigravity biceps and/or triceps function due to nerve surgery or natural history. Questionnaires were sent to surgeons participating in a prospective multicenter brachial plexus birth palsy study. With a response rate of 82 percent, the sample comprised 22 surgeons with extensive experience in treating brachial plexus birth palsy. The survey gathered collective information on two unique clinical groups: (1) infants with no antigravity biceps function but intact antigravity deltoid and radial nerve function and (2) infants with no antigravity radial nerve function (wrist and digital extension, triceps) but intact antigravity biceps and deltoid function. Analysis of data and age-based trends was performed using the Fisher's exact test. With failure of biceps recovery, surgeons preferred microsurgery for children 6 to 18 months old and tendon transfers for children older than 18 months. Both procedures were preferred over observation alone (p < 0.001). With regard to microsurgery techniques, with increasing age, surgeons used nerve transfers more than resected neuroma and grafting. With tendon transfers, regional transfers were performed more than 90 percent of the time at all ages. For patients with no antigravity radial nerve function, most cases at all ages were managed by observation rather than microsurgery or tendon transfers (p < 0.001). The authors' data indicate a general consensus in treatment choices for the two cases of microsurgical failure in infants with brachial plexus birth palsies as well as in satisfaction among experienced surgeons in using these treatments.

  15. Far transfer to language and math of a short software-based gaming intervention.

    PubMed

    Goldin, Andrea Paula; Hermida, María Julia; Shalom, Diego E; Elias Costa, Martín; Lopez-Rosenfeld, Matías; Segretin, María Soledad; Fernández-Slezak, Diego; Lipina, Sebastián J; Sigman, Mariano

    2014-04-29

    Executive functions (EF) in children can be trained, but it remains unknown whether training-related benefits elicit far transfer to real-life situations. Here, we investigate whether a set of computerized games might yield near and far transfer on an experimental and an active control group of low-SES otherwise typically developing 6-y-olds in a 3-mo pretest-training-posttest design that was ecologically deployed (at school). The intervention elicits transfer to some (but not all) facets of executive function. These changes cascade to real-world measures of school performance. The intervention equalizes academic outcomes across children who regularly attend school and those who do not because of social and familiar circumstances.

  16. Investigation of ground state charge transfer complex between paracetamol and p-chloranil through DFT and UV-visible studies

    NASA Astrophysics Data System (ADS)

    Shukla, Madhulata; Srivastava, Nitin; Saha, Satyen

    2012-08-01

    The present report deals with the theoretical investigation on ground state structure and charge transfer (CT) transitions in paracetamol (PA)/p-chloranil (CA) complex using Density Functional Theory (DFT) and Time Dependent Density Functional Theory (TD-DFT) method. It is found that Cdbnd O bond length of p-chloranil increases on complexation with paracetamol along with considerable amount of charge transfer from PA to CA. TD-DFT calculations have been performed to analyse the observed UV-visible spectrum of PA-CA charge transferred complex. Interestingly, in addition to expected CT transition, a weak symmetry relieved π-π* transition in the chloranil is also observed.

  17. Charge transfer in iridate-manganite superlattices

    DOE PAGES

    Okamoto, Satoshi; Nichols, John; Sohn, Changhee; ...

    2017-03-03

    Charge transfer in superlattices consisting of SrIrOmore » $$_3$$ and SrMnO$$_3$$ is investigated using density functional theory. Despite the nearly identical work function and non-polar interfaces between SrIrO$$_3$$ and SrMnO$$_3$$, rather large charge transfer was experimentally reported between them. Our results provide a qualitative understanding to such experimental reports. We further develop a microscopic model that captures the mechanism behind this phenomenon. This leads to unique strain dependence of such charge transfer in iridate-manganite superlattices. The predicted behavior is consistently verified by experiment. Lastly, our work thus demonstrates a new route to control electronic states in non-polar oxide heterostructures.« less

  18. Development of model for studies on momentum transfer in electrochemical cells with entry region coil as turbulence promoter

    NASA Astrophysics Data System (ADS)

    Penta Rao, Tamarba; Rajendra Prasad, P.

    2018-04-01

    Entry region swirl promoters gain importance in industry because of its effectiveness in augmentation of mass and heat transfer augmentation. Design of equipment needs momentum transfer data along with mass or heat transfer data. Hence an experimental investigation was carried out with coaxially placed entry region spiral coil as turbulence promoters on momentum transfer in forced convection flow of electrolyte in circular conduits. Aqueous solution of sodium hydroxide and 0.01 M equimolal Ferri-ferro cyanide system was chosen for the study. The study covered parameters like effect of pitch of the coil, effect of length of the coil, diameter of the coil, diameter of the coil wire, diameter of the annular rod. The promoter is measured by limiting current technique using diffusion controlled electrochemical reactions. The study comprises of evaluation of momentum transfer rates at the outer wall of the electrochemical cell. Pressure drop measurements were also made to obtain the energy consumption pattern. Within the range of variables covered. The results are correlated by the momentum transfer similarity function. Momentum transfer coefficients were evaluated from measured limiting currents. Effect of each parameter was studied in terms of friction factor. A model was developed for momentum transfer. The experimental data on momentum transfer was modeled in terms of momentum transfer function and Reynolds number, geometric parameters.

  19. Charge transfer in TATB and HMX under extreme conditions.

    PubMed

    Zhang, Chaoyang; Ma, Yu; Jiang, Daojian

    2012-11-01

    Charge transfer is usually accompanied by structural changes in materials under different conditions. However, the charge transfer in energetic materials that are subjected to extreme conditions has seldom been explored by researchers. In the work described here, the charge transfer in single molecules and unit cells of the explosives TATB and HMX under high temperatures and high pressures was investigated by performing static and dynamic calculations using three DFT methods, including the PWC functional of LDA, and the BLYP and PBE functionals of GGA. The results showed that negative charge is transferred from the nitro groups of molecular or crystalline TATB and HMX when they are heated. All DFT calculations for the compressed TATB unit cell indicate that, generally, negative charge transfer occurs to its nitro groups as the compression increases. PWC and PBE calculations for crystalline HMX show that negative charge is first transferred to the nitro groups but, as the compression increases, the negative charge is transferred from the nitro groups. However, the BLYP calculations indicated that there was gradual negative charge transfer to the nitro groups of HMX, similar to the case for TATB. The unrelaxed state of the uniformly compressed TATB causes negative charge to be transferred from its nitro groups, in contrast to what is seen in the relaxed state. Charge transfer in TATB is predicted to occur much more easily than in HMX.

  20. Using Multiple Schedules during Functional Communication Training to Promote Rapid Transfer of Treatment Effects

    ERIC Educational Resources Information Center

    Fisher, Wayne W.; Greer, Brian D.; Fuhrman, Ashley M.; Querim, Angie C.

    2015-01-01

    Multiple schedules with signaled periods of reinforcement and extinction have been used to thin reinforcement schedules during functional communication training (FCT) to make the intervention more practical for parents and teachers. We evaluated whether these signals would also facilitate rapid transfer of treatment effects across settings and…

  1. Solution of the radiative transfer equation for Rayleigh scattering using the infinite medium Green's function

    NASA Astrophysics Data System (ADS)

    Biçer, M.; Kaşkaş, A.

    2018-03-01

    The infinite medium Green's function is used to solve the half-space albedo, slab albedo and Milne problems for the unpolarized Rayleigh scattering case; these problems are the most classical problems of radiative transfer theory. The numerical results are obtained and are compared with previous ones.

  2. Experience with k-epsilon turbulence models for heat transfer computations in rotating

    NASA Technical Reports Server (NTRS)

    Tekriwal, Prabbat

    1995-01-01

    This viewgraph presentation discusses geometry and flow configuration, effect of y+ on heat transfer computations, standard and extended k-epsilon turbulence model results with wall function, low-Re model results (the Lam-Bremhorst model without wall function), a criterion for flow reversal in a radially rotating square duct, and a summary.

  3. The Derived Transfer and Reversal of Mood Functions through Equivalence Relations: II

    ERIC Educational Resources Information Center

    Cahill, Jane; Barnes-Holmes, Yvonne; Barnes-Holmes, Dermot; Rodriguez-Valverde, Miguel; Luciano, Carmen; Smeets, Paul M.

    2007-01-01

    Recent research has demonstrated the transfer of induced mood functions through equivalence relations by means of a musical mood-induction procedure. The research described in this article replicated and extended such work, primarily with the inclusion of a baseline and two types of reversal procedures. First, 16 adult participants were trained…

  4. Green's function solution to radiative heat transfer between longitudinal gray fins

    NASA Technical Reports Server (NTRS)

    Frankel, J. I.; Silvestri, J. J.

    1991-01-01

    A demonstration is presented of the applicability and versatility of a pure integral formulation for radiative-conductive heat-transfer problems. Preliminary results have been obtained which indicate that this formulation allows an accurate, fast, and stable computation procedure to be implemented. Attention is given to the accessory problem defining Green's function.

  5. Transfer of learning relates to intrinsic connectivity between hippocampus, ventromedial prefrontal cortex, and large-scale networks.

    PubMed

    Gerraty, Raphael T; Davidow, Juliet Y; Wimmer, G Elliott; Kahn, Itamar; Shohamy, Daphna

    2014-08-20

    An important aspect of adaptive learning is the ability to flexibly use past experiences to guide new decisions. When facing a new decision, some people automatically leverage previously learned associations, while others do not. This variability in transfer of learning across individuals has been demonstrated repeatedly and has important implications for understanding adaptive behavior, yet the source of these individual differences remains poorly understood. In particular, it is unknown why such variability in transfer emerges even among homogeneous groups of young healthy participants who do not vary on other learning-related measures. Here we hypothesized that individual differences in the transfer of learning could be related to relatively stable differences in intrinsic brain connectivity, which could constrain how individuals learn. To test this, we obtained a behavioral measure of memory-based transfer outside of the scanner and on a separate day acquired resting-state functional MRI images in 42 participants. We then analyzed connectivity across independent component analysis-derived brain networks during rest, and tested whether intrinsic connectivity in learning-related networks was associated with transfer. We found that individual differences in transfer were related to intrinsic connectivity between the hippocampus and the ventromedial prefrontal cortex, and between these regions and large-scale functional brain networks. Together, the findings demonstrate a novel role for intrinsic brain dynamics in flexible learning-guided behavior, both within a set of functionally specific regions known to be important for learning, as well as between these regions and the default and frontoparietal networks, which are thought to serve more general cognitive functions. Copyright © 2014 the authors 0270-6474/14/3411297-07$15.00/0.

  6. OPTICAL INFORMATION PROCESSING: Modulation—spectral analysis of an image transmitted across a distorting medium

    NASA Astrophysics Data System (ADS)

    Zubov, Vladimir A.; Mironova, T. V.

    1998-05-01

    The task of simultaneous determination of the structure and characteristics of a two-dimensional amplitude—phase signal and a two-dimensional complex transfer or instrumental function is considered. The solution is based on determination of four independent intensity distributions of spectral representations of the signal Isr(ωx, ωy) subjected to the action of the transfer function, of the signal Ismr(ωx, ωy which) has experienced additional modulation applied in a certain manner and the action of the transfer function, of the signal Isrn(ωx, ωy) representing the signal Isr(ωx, ωy) with certain additional modulation at the output, and of the signal Ismrn(ωx, ωy) which is the signal Ismr(ωx, ωy) with certain additional modulation at the output. These intensity distributions make it possible to calculate the amplitude and phase components of the image being analysed and of the transfer function. Additional modulations should in some way ensure visualisation of the phase information. A specific type of additional spatial modulation, in the form of linear amplitude, is discussed.

  7. Semantic layers for illustrative volume rendering.

    PubMed

    Rautek, Peter; Bruckner, Stefan; Gröller, Eduard

    2007-01-01

    Direct volume rendering techniques map volumetric attributes (e.g., density, gradient magnitude, etc.) to visual styles. Commonly this mapping is specified by a transfer function. The specification of transfer functions is a complex task and requires expert knowledge about the underlying rendering technique. In the case of multiple volumetric attributes and multiple visual styles the specification of the multi-dimensional transfer function becomes more challenging and non-intuitive. We present a novel methodology for the specification of a mapping from several volumetric attributes to multiple illustrative visual styles. We introduce semantic layers that allow a domain expert to specify the mapping in the natural language of the domain. A semantic layer defines the mapping of volumetric attributes to one visual style. Volumetric attributes and visual styles are represented as fuzzy sets. The mapping is specified by rules that are evaluated with fuzzy logic arithmetics. The user specifies the fuzzy sets and the rules without special knowledge about the underlying rendering technique. Semantic layers allow for a linguistic specification of the mapping from attributes to visual styles replacing the traditional transfer function specification.

  8. Nerve transfers for restoration of upper extremity motor function in a child with upper extremity motor deficits due to transverse myelitis: case report.

    PubMed

    Dorsi, Michael J; Belzberg, Allan J

    2012-01-01

    Transverse myelitis (TM) may result in permanent neurologic dysfunction. Nerve transfers have been developed to restore function after peripheral nerve injury. Here, we present a case report of a child with permanent right upper extremity weakness due to TM that underwent nerve transfers. The following procedures were performed: double fascicle transfer from median nerve and ulnar nerve to the brachialis and biceps branches of the musculocutaneous nerve, spinal accessory to suprascapular nerve, and medial cord to axillary nerve end-to-side neurorraphy. At 22 months, the patient demonstrated excellent recovery of elbow flexion with minimal improvement in shoulder abduction. We propose that the treatment of permanent deficits from TM represents a novel indication for nerve transfers in a subset of patients. Copyright © 2011 Wiley Periodicals, Inc.

  9. The psycholegal factors for juvenile transfer and reverse transfer evaluations.

    PubMed

    King, Christopher M

    2018-01-01

    It remains unclear whether forensic mental health assessments for juvenile reverse transfer (to juvenile court) are distinct from those for juvenile transfer (to adult court). This survey consisted of an updated review of transfer and reverse transfer laws (in jurisdictions that have both mechanisms) in light of the generally accepted three-factor model of functional legal capacities involved in transfer evaluations (i.e., risk, sophistication-maturity, and treatment amenability). Results indicated that a majority of states' reverse transfer statutes refer explicitly or implicitly to the same three psycholegal constructs identified as central for transfer. Given the legal similarity between transfer and reverse transfer, potential practice implications and directions for future research are discussed. Copyright © 2017 John Wiley & Sons, Ltd.

  10. A linear programming approach to characterizing norm bounded uncertainty from experimental data

    NASA Technical Reports Server (NTRS)

    Scheid, R. E.; Bayard, D. S.; Yam, Y.

    1991-01-01

    The linear programming spectral overbounding and factorization (LPSOF) algorithm, an algorithm for finding a minimum phase transfer function of specified order whose magnitude tightly overbounds a specified nonparametric function of frequency, is introduced. This method has direct application to transforming nonparametric uncertainty bounds (available from system identification experiments) into parametric representations required for modern robust control design software (i.e., a minimum-phase transfer function multiplied by a norm-bounded perturbation).

  11. Imaging performance of an isotropic negative dielectric constant slab.

    PubMed

    Shivanand; Liu, Huikan; Webb, Kevin J

    2008-11-01

    The influence of material and thickness on the subwavelength imaging performance of a negative dielectric constant slab is studied. Resonance in the plane-wave transfer function produces a high spatial frequency ripple that could be useful in fabricating periodic structures. A cost function based on the plane-wave transfer function provides a useful metric to evaluate the planar slab lens performance, and using this, the optimal slab dielectric constant can be determined.

  12. Influence of speckle image reconstruction on photometric precision for large solar telescopes

    NASA Astrophysics Data System (ADS)

    Peck, C. L.; Wöger, F.; Marino, J.

    2017-11-01

    Context. High-resolution observations from large solar telescopes require adaptive optics (AO) systems to overcome image degradation caused by Earth's turbulent atmosphere. AO corrections are, however, only partial. Achieving near-diffraction limited resolution over a large field of view typically requires post-facto image reconstruction techniques to reconstruct the source image. Aims: This study aims to examine the expected photometric precision of amplitude reconstructed solar images calibrated using models for the on-axis speckle transfer functions and input parameters derived from AO control data. We perform a sensitivity analysis of the photometric precision under variations in the model input parameters for high-resolution solar images consistent with four-meter class solar telescopes. Methods: Using simulations of both atmospheric turbulence and partial compensation by an AO system, we computed the speckle transfer function under variations in the input parameters. We then convolved high-resolution numerical simulations of the solar photosphere with the simulated atmospheric transfer function, and subsequently deconvolved them with the model speckle transfer function to obtain a reconstructed image. To compute the resulting photometric precision, we compared the intensity of the original image with the reconstructed image. Results: The analysis demonstrates that high photometric precision can be obtained for speckle amplitude reconstruction using speckle transfer function models combined with AO-derived input parameters. Additionally, it shows that the reconstruction is most sensitive to the input parameter that characterizes the atmospheric distortion, and sub-2% photometric precision is readily obtained when it is well estimated.

  13. The split hypoglossal nerve versus the cross-face nerve graft to supply the free functional muscle transfer for facial reanimation: A comparative study.

    PubMed

    Amer, Tarek A; El Kholy, Mohamed S

    2018-05-01

    Long-standing cases of facial paralysis are currently treated with free functional muscle transfer. Several nerves are mentioned in the literature to supply the free muscle transfer. The aim of this study is to compare the split hypoglossal nerve and the cross-face nerve graft to supply the free functional muscle transfer in facial reanimation. Of 94 patients with long-standing, unilateral facial palsy, 49 were treated using the latissimus dorsi muscle supplied by the split hypoglossal nerve, and 45 patients were treated using the latissmus dorsi muscle supplied by healthy contralateral buccal branch of the facial nerve. The excursion gained by the free muscle transfer supplied by the split hypoglossal nerve (mean 19.20 ± 6.321) was significantly higher (P value 0.001) than that obtained by the contralateral buccal branch of the facial nerve (mean 14.59 ± 6.245). The split hypoglossal nerve appears to be a good possible option to supply the free vascularised muscle transfer in facial reanimation. It yields a stronger excursion in less time than the contralateral cross-face nerve graft. Copyright © 2018 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

  14. Reconstructive microsurgery in pediatric population-a series of 25 patients.

    PubMed

    Yildirim, Serkan; Calikapan, Gaye Taylan; Akoz, Tayfun

    2008-01-01

    Pediatric microsurgery procedures possess various difficulties when compared with adults. However, both free tissue transfers and replantation of the amputated parts show remarkable success rates in children. The concerns of survival of the flaps and the amputated parts have shifted to the function of these in the adulthood. Several key points and hints allow successfull rates for both survival and function. We present a series of microsurgical procedures both free tissue transfers (12 patients) and digital replantations (13 patients). Free tissue transfers included toe-to-hand transfers in 5, latissimus dorsi flaps in 4, fibular flaps in 4, and anterolateral thigh flaps in 2 patients. Thirteen patients involved 17 digital replantations. The survival rate was less in the replantation group (58.75%) than in the free tissue transfer group (93%). Both the functional and the cosmetic results were promising. The follow-up period was between 1 and 6 years (mean 37 months) for the free tissue transfer group and 1-5 years (mean 20 months) for the replantation group. The major technical difficulties include the age group of 0-2 years. Aside from these the high capacity of regeneration and the improved learning capacity increase the feasibility of the microsurgical procedures proceeded among children. Copyright 2008 Wiley-Liss, Inc. Microsurgery, 2008.

  15. Ion/Ion Reactions with "Onium" Reagents: An Approach for the Gas-phase Transfer of Organic Cations to Multiply-Charged Anions

    NASA Astrophysics Data System (ADS)

    Gilbert, Joshua D.; Prentice, Boone M.; McLuckey, Scott A.

    2015-05-01

    The use of ion/ion reactions to effect gas-phase alkylation is demonstrated. Commonly used fixed-charge "onium" cations are well-suited for ion/ion reactions with multiply deprotonated analytes because of their tendency to form long-lived electrostatic complexes. Activation of these complexes results in an SN2 reaction that yields an alkylated anion with the loss of a neutral remnant of the reagent. This alkylation process forms the basis of a general method for alkylation of deprotonated analytes generated via electrospray, and is demonstrated on a variety of anionic sites. SN2 reactions of this nature are demonstrated empirically and characterized using density functional theory (DFT). This method for modification in the gas phase is extended to the transfer of larger and more complex R groups that can be used in later gas-phase synthesis steps. For example, N-cyclohexyl- N'-(2-morpholinoethyl)carbodiimide (CMC) is used to transfer a carbodiimide functionality to a peptide anion containing a carboxylic acid. Subsequent activation yields a selective reaction between the transferred carbodiimide group and a carboxylic acid, suggesting the carbodiimide functionality is retained through the transfer process. Many different R groups are transferable using this method, allowing for new possibilities for charge manipulation and derivatization in the gas phase.

  16. Transfer functions for protein signal transduction: application to a model of striatal neural plasticity.

    PubMed

    Scheler, Gabriele

    2013-01-01

    We present a novel formulation for biochemical reaction networks in the context of protein signal transduction. The model consists of input-output transfer functions, which are derived from differential equations, using stable equilibria. We select a set of "source" species, which are interpreted as input signals. Signals are transmitted to all other species in the system (the "target" species) with a specific delay and with a specific transmission strength. The delay is computed as the maximal reaction time until a stable equilibrium for the target species is reached, in the context of all other reactions in the system. The transmission strength is the concentration change of the target species. The computed input-output transfer functions can be stored in a matrix, fitted with parameters, and even recalled to build dynamical models on the basis of state changes. By separating the temporal and the magnitudinal domain we can greatly simplify the computational model, circumventing typical problems of complex dynamical systems. The transfer function transformation of biochemical reaction systems can be applied to mass-action kinetic models of signal transduction. The paper shows that this approach yields significant novel insights while remaining a fully testable and executable dynamical model for signal transduction. In particular we can deconstruct the complex system into local transfer functions between individual species. As an example, we examine modularity and signal integration using a published model of striatal neural plasticity. The modularizations that emerge correspond to a known biological distinction between calcium-dependent and cAMP-dependent pathways. Remarkably, we found that overall interconnectedness depends on the magnitude of inputs, with higher connectivity at low input concentrations and significant modularization at moderate to high input concentrations. This general result, which directly follows from the properties of individual transfer functions, contradicts notions of ubiquitous complexity by showing input-dependent signal transmission inactivation.

  17. Multiconfiguration Pair-Density Functional Theory Is as Accurate as CASPT2 for Electronic Excitation.

    PubMed

    Hoyer, Chad E; Ghosh, Soumen; Truhlar, Donald G; Gagliardi, Laura

    2016-02-04

    A correct description of electronically excited states is critical to the interpretation of visible-ultraviolet spectra, photochemical reactions, and excited-state charge-transfer processes in chemical systems. We have recently proposed a theory called multiconfiguration pair-density functional theory (MC-PDFT), which is based on a combination of multiconfiguration wave function theory and a new kind of density functional called an on-top density functional. Here, we show that MC-PDFT with a first-generation on-top density functional performs as well as CASPT2 for an organic chemistry database including valence, Rydberg, and charge-transfer excitations. The results are very encouraging for practical applications.

  18. Tuning the photoluminescence of graphene quantum dots through the charge transfer effect of functional groups.

    PubMed

    Jin, Sung Hwan; Kim, Da Hye; Jun, Gwang Hoon; Hong, Soon Hyung; Jeon, Seokwoo

    2013-02-26

    The band gap properties of graphene quantum dots (GQDs) arise from quantum confinement effects and differ from those in semimetallic graphene sheets. Tailoring the size of the band gap and understanding the band gap tuning mechanism are essential for the applications of GQDs in opto-electronics. In this study, we observe that the photoluminescence (PL) of the GQDs shifts due to charge transfers between functional groups and GQDs. GQDs that are functionalized with amine groups and are 1-3 layers thick and less than 5 nm in diameter were successfully fabricated using a two-step cutting process from graphene oxides (GOs). The functionalized GQDs exhibit a redshift of PL emission (ca. 30 nm) compared to the unfunctionalized GQDs. Furthermore, the PL emissions of the GQDs and the amine-functionalized GQDs were also shifted by changes in the pH due to the protonation or deprotonation of the functional groups. The PL shifts resulted from charge transfers between the functional groups and GQDs, which can tune the band gap of the GQDs. Calculations from density functional theory (DFT) are in good agreement with our proposed mechanism for band gap tuning in the GQDs through the use of functionalization.

  19. Double second toe transfer in congenital hand anomalies.

    PubMed

    Van Holder, C; Giele, H; Gilbert, A

    1999-08-01

    A series of 14 patients with congenital hand anomalies who received staged double second toe transfers to the same hand for restoration of function or form were reviewed retrospectively. There were three children with constriction ring syndrome, two with symbrachydactyly and nine with transverse absence (failure of formation). There were different indications, technical difficulties and results with the various anomalies. All transferred toes were mobile and sensate, and were reported to be of benefit in both function and appearance. However, secondary surgical procedures were required in all patients.

  20. 17 CFR 240.17Ad-21T - Operational capability in a Year 2000 environment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... cessation or transfer of these functions. (e)(1)(i) If you are a registered non-bank transfer agent that has... every registered non-bank transfer agent that uses computers in the conduct of its business as a...., Washington, DC 20549-6628 Attention: Y2K Compliance. (d)(1) If you are a registered non-bank transfer agent...

  1. Incorporation of charge transfer into the explicit polarization fragment method by grand canonical density functional theory.

    PubMed

    Isegawa, Miho; Gao, Jiali; Truhlar, Donald G

    2011-08-28

    Molecular fragmentation algorithms provide a powerful approach to extending electronic structure methods to very large systems. Here we present a method for including charge transfer between molecular fragments in the explicit polarization (X-Pol) fragment method for calculating potential energy surfaces. In the conventional X-Pol method, the total charge of each fragment is preserved, and charge transfer between fragments is not allowed. The description of charge transfer is made possible by treating each fragment as an open system with respect to the number of electrons. To achieve this, we applied Mermin's finite temperature method to the X-Pol wave function. In the application of this method to X-Pol, the fragments are open systems that partially equilibrate their number of electrons through a quasithermodynamics electron reservoir. The number of electrons in a given fragment can take a fractional value, and the electrons of each fragment obey the Fermi-Dirac distribution. The equilibrium state for the electrons is determined by electronegativity equalization with conservation of the total number of electrons. The amount of charge transfer is controlled by re-interpreting the temperature parameter in the Fermi-Dirac distribution function as a coupling strength parameter. We determined this coupling parameter so as to reproduce the charge transfer energy obtained by block localized energy decomposition analysis. We apply the new method to ten systems, and we show that it can yield reasonable approximations to potential energy profiles, to charge transfer stabilization energies, and to the direction and amount of charge transferred. © 2011 American Institute of Physics

  2. Incorporation of charge transfer into the explicit polarization fragment method by grand canonical density functional theory

    PubMed Central

    Isegawa, Miho; Gao, Jiali; Truhlar, Donald G.

    2011-01-01

    Molecular fragmentation algorithms provide a powerful approach to extending electronic structure methods to very large systems. Here we present a method for including charge transfer between molecular fragments in the explicit polarization (X-Pol) fragment method for calculating potential energy surfaces. In the conventional X-Pol method, the total charge of each fragment is preserved, and charge transfer between fragments is not allowed. The description of charge transfer is made possible by treating each fragment as an open system with respect to the number of electrons. To achieve this, we applied Mermin's finite temperature method to the X-Pol wave function. In the application of this method to X-Pol, the fragments are open systems that partially equilibrate their number of electrons through a quasithermodynamics electron reservoir. The number of electrons in a given fragment can take a fractional value, and the electrons of each fragment obey the Fermi–Dirac distribution. The equilibrium state for the electrons is determined by electronegativity equalization with conservation of the total number of electrons. The amount of charge transfer is controlled by re-interpreting the temperature parameter in the Fermi–Dirac distribution function as a coupling strength parameter. We determined this coupling parameter so as to reproduce the charge transfer energy obtained by block localized energy decomposition analysis. We apply the new method to ten systems, and we show that it can yield reasonable approximations to potential energy profiles, to charge transfer stabilization energies, and to the direction and amount of charge transferred. PMID:21895159

  3. Phloem as Capacitor: Radial Transfer of Water into Xylem of Tree Stems Occurs via Symplastic Transport in Ray Parenchyma[OPEN

    PubMed Central

    Renard, Justine; Tjoelker, Mark G.; Salih, Anya

    2015-01-01

    The transfer of water from phloem into xylem is thought to mitigate increasing hydraulic tension in the vascular system of trees during the diel cycle of transpiration. Although a putative plant function, to date there is no direct evidence of such water transfer or the contributing pathways. Here, we trace the radial flow of water from the phloem into the xylem and investigate its diel variation. Introducing a fluorescent dye (0.1% [w/w] fluorescein) into the phloem water of the tree species Eucalyptus saligna allowed localization of the dye in phloem and xylem tissues using confocal laser scanning microscopy. Our results show that the majority of water transferred between the two tissues is facilitated via the symplast of horizontal ray parenchyma cells. The method also permitted assessment of the radial transfer of water during the diel cycle, where changes in water potential gradients between phloem and xylem determine the extent and direction of radial transfer. When injected during the morning, when xylem water potential rapidly declined, fluorescein was translocated, on average, farther into mature xylem (447 ± 188 µm) compared with nighttime, when xylem water potential was close to zero (155 ± 42 µm). These findings provide empirical evidence to support theoretical predictions of the role of phloem-xylem water transfer in the hydraulic functioning of plants. This method enables investigation of the role of phloem tissue as a dynamic capacitor for water storage and transfer and its contribution toward the maintenance of the functional integrity of xylem in trees. PMID:25588734

  4. Pathogen transfer through environment-host contact: an agent-based queueing theoretic framework.

    PubMed

    Chen, Shi; Lenhart, Suzanne; Day, Judy D; Lee, Chihoon; Dulin, Michael; Lanzas, Cristina

    2017-11-02

    Queueing theory studies the properties of waiting queues and has been applied to investigate direct host-to-host transmitted disease dynamics, but its potential in modelling environmentally transmitted pathogens has not been fully explored. In this study, we provide a flexible and customizable queueing theory modelling framework with three major subroutines to study the in-hospital contact processes between environments and hosts and potential nosocomial pathogen transfer, where environments are servers and hosts are customers. Two types of servers with different parameters but the same utilization are investigated. We consider various forms of transfer functions that map contact duration to the amount of pathogen transfer based on existing literature. We propose a case study of simulated in-hospital contact processes and apply stochastic queues to analyse the amount of pathogen transfer under different transfer functions, and assume that pathogen amount decreases during the inter-arrival time. Different host behaviour (feedback and non-feedback) as well as initial pathogen distribution (whether in environment and/or in hosts) are also considered and simulated. We assess pathogen transfer and circulation under these various conditions and highlight the importance of the nonlinear interactions among contact processes, transfer functions and pathogen demography during the contact process. Our modelling framework can be readily extended to more complicated queueing networks to simulate more realistic situations by adjusting parameters such as the number and type of servers and customers, and adding extra subroutines. © The authors 2017. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. All rights reserved.

  5. The Grandmaternal Transference in Parent-Infant/Child Psychotherapy

    ERIC Educational Resources Information Center

    Dugmore, Nicola

    2013-01-01

    The psychic significance of the figure of the grandmother in psychodynamic psychotherapy has received scant attention. This paper develops the concept of the "grandmaternal transference" in parent-infant psychotherapy and explores its identification, its possible functions and its therapeutic significance. The grandmaternal transference has…

  6. Effects of partial slip boundary condition and radiation on the heat and mass transfer of MHD-nanofluid flow

    NASA Astrophysics Data System (ADS)

    Abd Elazem, Nader Y.; Ebaid, Abdelhalim

    2017-12-01

    In this paper, the effect of partial slip boundary condition on the heat and mass transfer of the Cu-water and Ag-water nanofluids over a stretching sheet in the presence of magnetic field and radiation. Such partial slip boundary condition has attracted much attention due to its wide applications in industry and chemical engineering. The flow is basically governing by a system of partial differential equations which are reduced to a system of ordinary differential equations. This system has been exactly solved, where exact analytical expression has been obtained for the fluid velocity in terms of exponential function, while the temperature distribution, and the nanoparticles concentration are expressed in terms of the generalized incomplete gamma function. In addition, explicit formulae are also derived from the rates of heat transfer and mass transfer. The effects of the permanent parameters on the skin friction, heat transfer coefficient, rate of mass transfer, velocity, the temperature profile, and concentration profile have been discussed through tables and graphs.

  7. Acoustic Wave Propagation in Pressure Sense Lines

    NASA Technical Reports Server (NTRS)

    Vitarius, Patrick; Gregory, Don A.; Wiley, John; Korman, Valentin

    2003-01-01

    Sense lines are used in pressure measurements to passively transmit information from hostile environments to areas where transducers can be used. The transfer function of a sense line can be used to obtain information about the measured environment from the protected sensor. Several properties of this transfer function are examined, including frequency dependence, Helmholtz resonance, and time of flight delay.

  8. Change in Attachment Patterns and Reflective Function in a Randomized Control Trial of Transference-Focused Psychotherapy for Borderline Personality Disorder

    ERIC Educational Resources Information Center

    Levy, Kenneth N.; Meehan, Kevin B.; Kelly, Kristen M.; Reynoso, Joseph S.; Weber, Michal; Clarkin, John F.; Kernberg, Otto F.

    2006-01-01

    Changes in attachment organization and reflective function (RF) were assessed as putative mechanisms of change in 1 of 3 year-long psychotherapy treatments for patients with borderline personality disorder (BPD). Ninety patients reliably diagnosed with BPD were randomized to transference-focused psychotherapy (TFP), dialectical behavior…

  9. Manual control analysis of drug effects on driving performance

    NASA Technical Reports Server (NTRS)

    Smiley, A.; Ziedman, K.; Moskowitz, H.

    1981-01-01

    The effects of secobarbital, diazepam, alcohol, and marihuana on car-driver transfer functions obtained using a driving simulator were studied. The first three substances, all CNS depressants, reduced gain, crossover frequency, and coherence which resulted in poorer tracking performance. Marihuana also impaired tracking performance but the only effect on the transfer function parameters was to reduce coherence.

  10. Optical and infrared transfer function of the Lageos retroreflector array

    NASA Technical Reports Server (NTRS)

    Arnold, D. A.

    1978-01-01

    The transfer function of the retroreflector array carried by the LAGEOS satellite (1976 39A) was computed at three wavelengths: 5230, 6943, and 106000 A. The range correction is given for extrapolating laser range measurements to the center of gravity of the satellite. The reflectivity of the array was calculated for estimating laser-echo signal strengths.

  11. Hubble Space Telescope On-orbit Transfer Function Test

    NASA Technical Reports Server (NTRS)

    Vadlamudi, N.; Blair, M. A.; Clapp, B. R.

    1992-01-01

    The paper describes the On-orbit Transfer Function Test (TFT) designed for on-orbit vibration testing of the Hubble Space Telescope (HST). The TFT provides means for extracting accurate on-orbit characteristics of HST flexible body dynamics, making it possible to check periodically the state of the vehicle on-orbit and to assess changes in modal parameters.

  12. Method and apparatus for transfer function simulator for testing complex systems

    NASA Technical Reports Server (NTRS)

    Kavaya, M. J. (Inventor)

    1985-01-01

    A method and apparatus for testing the operation of a complex stabilization circuit in a closed loop system is presented. The method is comprised of a programmed analog or digital computing system for implementing the transfer function of a load thereby providing a predictable load. The digital computing system employs a table stored in a microprocessor in which precomputed values of the load transfer function are stored for values of input signal from the stabilization circuit over the range of interest. This technique may be used not only for isolating faults in the stabilization circuit, but also for analyzing a fault in a faulty load by so varying parameters of the computing system as to simulate operation of the actual load with the fault.

  13. High-level user interfaces for transfer function design with semantics.

    PubMed

    Salama, Christof Rezk; Keller, Maik; Kohlmann, Peter

    2006-01-01

    Many sophisticated techniques for the visualization of volumetric data such as medical data have been published. While existing techniques are mature from a technical point of view, managing the complexity of visual parameters is still difficult for non-expert users. To this end, this paper presents new ideas to facilitate the specification of optical properties for direct volume rendering. We introduce an additional level of abstraction for parametric models of transfer functions. The proposed framework allows visualization experts to design high-level transfer function models which can intuitively be used by non-expert users. The results are user interfaces which provide semantic information for specialized visualization problems. The proposed method is based on principal component analysis as well as on concepts borrowed from computer animation.

  14. Application of the polychromatic defocus transfer function to multifocal lenses.

    PubMed

    Schwiegerling, Jim; Choi, Junoh

    2008-11-01

    To model the performance of multifocal lenses in polychromatic lighting. The defocus transfer function (DTF) is a mathematical technique for illustrating the optical transfer function for all levels of defocus at a given wavelength. A polychromatic version of the DTF is developed that accounts for changes in cutoff frequency, reduction in diffraction efficiency, ocular chromatic aberration, and photoreceptor spectral sensitivity. The differences between the monochromatic and polychromatic DTF are illustrated with a diffractive multifocal intraocular lens. Polychromatic analysis shows an increase in depth of field of diffractive lenses relative to assessment at a single wavelength. The polychromatic DTF is a useful tool for analyzing presbyopia treatments under "white-light" viewing conditions and provides feedback to lens designers on anticipated performance.

  15. Determination of poles and zeros of transfer functions for flexible spacecraft attitude control

    NASA Technical Reports Server (NTRS)

    Ohkami, Y.; Likins, P. W.

    1976-01-01

    The transfer function matrix is obtained for a three-input and three-output model of minimum sensors and actuators for the attitude control system of flexible spacecraft, and a method is described for determining the poles and zeros of this transfer function. Three cases are considered: (1) the actuators and the sensors are all attached to the primary body, (2) the actuators are on the primary body and the sensors are on the sub-body, and (3) the actuators are on the sub-body and the sensors are on the primary body. The zero-determination problem is shown to reduce to eigenvalue calculations of a matrix which is constructed from the inertial and modal matrices in a simple fashion.

  16. One-step direct transfer of pristine single-walled carbon nanotubes for functional nanoelectronics.

    PubMed

    Wu, Chung Chiang; Liu, Chang Hua; Zhong, Zhaohui

    2010-03-10

    We report a one-step direct transfer technique for the fabrication of functional nanoelectronic devices using pristine single-walled carbon nanotubes (SWNTs). Suspended SWNTs grown by the chemical vapor deposition (CVD) method are aligned and directly transferred onto prepatterned device electrodes at ambient temperature. Using this technique, we successfully fabricated SWNT electromechanical resonators with gate-tunable resonance frequencies. A fully suspended SWNT p-n diode has also been demonstrated with the diode ideality factor equal to 1. Our method eliminates the organic residues on SWNTs resulting from conventional lithography and solution processing. The results open up opportunities for the fundamental study of electron transport physics in ultraclean SWNTs and for room temperature fabrication of novel functional devices based on pristine SWNTs.

  17. Exact finite elements for conduction and convection

    NASA Technical Reports Server (NTRS)

    Thornton, E. A.; Dechaumphai, P.; Tamma, K. K.

    1981-01-01

    An appproach for developing exact one dimensional conduction-convection finite elements is presented. Exact interpolation functions are derived based on solutions to the governing differential equations by employing a nodeless parameter. Exact interpolation functions are presented for combined heat transfer in several solids of different shapes, and for combined heat transfer in a flow passage. Numerical results demonstrate that exact one dimensional elements offer advantages over elements based on approximate interpolation functions. Previously announced in STAR as N81-31507

  18. Interactive Computer Graphics for System Analysis.

    DTIC Science & Technology

    1983-12-01

    seven matrices have a maximum size of 10xlO and are named: AMAT BMAT CMAT DMAT KMAT FMAT GMAT ICECAP-II has available four transfer functions which B-1...is: COPY (source) (destination) The valid source and destination variables are: AMAT CMAT PMAT GTF KMAT BMAT DMAT GMAT HTF OLTF CLTF Transfer functions...Function: gtf, htf, oltf, cltf Enter choice of Matrix: AMAT, BMAT , CMAT, DMAT, FMAT, GMAT, KMAT Enter SETUP in order to set up State Space Model Enter

  19. Customized acoustic transform functions and their accuracy at predicting real-ear hearing aid performance.

    PubMed

    Munro, K J; Hatton, N

    2000-02-01

    The purpose of the study was to evaluate the validity of predicting the real-ear aided response by adding customized acoustic transform functions to the performance of a hearing aid in a 2-cc coupler. The real-ear hearing aid response, the real-ear-to-coupler difference (RECD/HA2), and field to behind-the-ear microphone transfer functions were measured in both ears of 24 normally hearing subjects using probe-tube microphone equipment. The RECD/HA2 transform function was obtained using both insert earphones and with the hearing aid/ pressure comparison method. An RECD/HA2 transfer function was also obtained with a customized earmold, ER-3A foam tip, and an oto-admittance tip. Validity estimates were calculated as the difference between the derived and measured real-ear response. The derived response was generally within 5 dB of the measured real-ear response when it incorporated an RECD/HA2 transform function obtained with a customized earmold for the specific ear in question. Discrepancies increased when the RECD/HA2 transfer function was obtained from the same subject but the opposite ear. There were significant differences between the RECD/HA2 transform function obtained with customized and temporary earmolds. As a result, the derived response incorporating these transforms differed significantly from the measured real-ear response obtained with the customized earmold. The insert earphone and the hearing aid RECD/HA2 transfer function were equally valid. The derived response may be used as a substitute for in situ hearing aid response procedures when it incorporates acoustic transform functions obtained with a customized earmold from the specific ear in question.

  20. On the calculation of charge transfer transitions with standard density functionals using constrained variational density functional theory.

    PubMed

    Ziegler, Tom; Krykunov, Mykhaylo

    2010-08-21

    It is well known that time-dependent density functional theory (TD-DFT) based on standard gradient corrected functionals affords both a quantitative and qualitative incorrect picture of charge transfer transitions between two spatially separated regions. It is shown here that the well known failure can be traced back to the use of linear response theory. Further, it is demonstrated that the inclusion of higher order terms readily affords a qualitatively correct picture even for simple functionals based on the local density approximation. The inclusion of these terms is done within the framework of a newly developed variational approach to excitation energies called constrained variational density functional theory (CV-DFT). To second order [CV(2)-DFT] this theory is identical to adiabatic TD-DFT within the Tamm-Dancoff approximation. With inclusion of fourth order corrections [CV(4)-DFT] it affords a qualitative correct description of charge transfer transitions. It is finally demonstrated that the relaxation of the ground state Kohn-Sham orbitals to first order in response to the change in density on excitation together with CV(4)-DFT affords charge transfer excitations in good agreement with experiment. The new relaxed theory is termed R-CV(4)-DFT. The relaxed scheme represents an effective way in which to introduce double replacements into the description of single electron excitations, something that would otherwise require a frequency dependent kernel.

  1. Nanoantioxidant-driven plasmon enhanced proton-coupled electron transfer

    NASA Astrophysics Data System (ADS)

    Sotiriou, Georgios A.; Blattmann, Christoph O.; Deligiannakis, Yiannis

    2015-12-01

    Proton-coupled electron transfer (PCET) reactions involve the transfer of a proton and an electron and play an important role in a number of chemical and biological processes. Here, we describe a novel phenomenon, plasmon-enhanced PCET, which is manifested using SiO2-coated Ag nanoparticles functionalized with gallic acid (GA), a natural antioxidant molecule that can perform PCET. These GA-functionalized nanoparticles show enhanced plasmonic response at near-IR wavelengths, due to particle agglomeration caused by the GA molecules. Near-IR laser irradiation induces strong local hot-spots on the SiO2-coated Ag nanoparticles, as evidenced by surface enhanced Raman scattering (SERS). This leads to plasmon energy transfer to the grafted GA molecules that lowers the GA-OH bond dissociation enthalpy by at least 2 kcal mol-1 and therefore facilitates PCET. The nanoparticle-driven plasmon-enhancement of PCET brings together the so far unrelated research domains of nanoplasmonics and electron/proton translocation with significant impact on applications based on interfacial electron/proton transfer.Proton-coupled electron transfer (PCET) reactions involve the transfer of a proton and an electron and play an important role in a number of chemical and biological processes. Here, we describe a novel phenomenon, plasmon-enhanced PCET, which is manifested using SiO2-coated Ag nanoparticles functionalized with gallic acid (GA), a natural antioxidant molecule that can perform PCET. These GA-functionalized nanoparticles show enhanced plasmonic response at near-IR wavelengths, due to particle agglomeration caused by the GA molecules. Near-IR laser irradiation induces strong local hot-spots on the SiO2-coated Ag nanoparticles, as evidenced by surface enhanced Raman scattering (SERS). This leads to plasmon energy transfer to the grafted GA molecules that lowers the GA-OH bond dissociation enthalpy by at least 2 kcal mol-1 and therefore facilitates PCET. The nanoparticle-driven plasmon-enhancement of PCET brings together the so far unrelated research domains of nanoplasmonics and electron/proton translocation with significant impact on applications based on interfacial electron/proton transfer. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr04942c

  2. Far transfer to language and math of a short software-based gaming intervention

    PubMed Central

    Goldin, Andrea Paula; Hermida, María Julia; Shalom, Diego E.; Elias Costa, Martín; Lopez-Rosenfeld, Matías; Segretin, María Soledad; Fernández-Slezak, Diego; Lipina, Sebastián J.; Sigman, Mariano

    2014-01-01

    Executive functions (EF) in children can be trained, but it remains unknown whether training-related benefits elicit far transfer to real-life situations. Here, we investigate whether a set of computerized games might yield near and far transfer on an experimental and an active control group of low-SES otherwise typically developing 6-y-olds in a 3-mo pretest–training–posttest design that was ecologically deployed (at school). The intervention elicits transfer to some (but not all) facets of executive function. These changes cascade to real-world measures of school performance. The intervention equalizes academic outcomes across children who regularly attend school and those who do not because of social and familiar circumstances. PMID:24711403

  3. Nonvascularized toe phalangeal transfer and distraction lengthening for symbrachydactyly.

    PubMed

    Patterson, Ryan W; Seitz, William H

    2010-04-01

    Symbrachydactyly describes a spectrum of congenital hand differences consisting of digital loss resulting in fused short fingers. As the principles for distraction lengthening have evolved, the technique of nonvascularized toe phalangeal transfer to the hand with shortened digits has provided patients with improved outcomes. Nonvascularized toe phalanx to hand transplant with distraction lengthening restores functional length to a skeletally deficient, poorly functioning hand while maintaining an overlying layer of vascular and sensate tissue. The primary goal is improvement of digital length to enhance mechanical advantage and prehension. We describe the technique of nonvascularized toe phalangeal transfer and distraction lengthening for symbrachydactyly, including the following steps: nonvascularized proximal toe phalanx harvest, toe phalanx transfer to hand, pin placement, osteotomy, and closure.

  4. Understanding the Charge Transfer at the Interface of Electron Donors and Acceptors: TTF–TCNQ as an Example

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Park, Changwon; Atalla, Viktor; Smith, Sean

    Charge transfer between an electron donor and an electron acceptor is widely accepted as being independent of their relative configurations if the interaction between them is weak; however, the limit of this concept for an interacting system has not yet been well established. Our study of prototypical electron donor–acceptor molecules, tetrathiafulvalene–tetracyanoquinodimethane, using density functional theory based on an advanced functional, clearly demonstrates that for interacting molecules, their configurational arrangement is as important as their individual electronic properties in the asymptotic limit to determine the charge transfer direction. For the first time, we demonstrate that by changing their relative orientation, onemore » can reverse the charge transfer direction of the pair, causing the molecules to exchange roles as donor and acceptor. In conclusion, our theory has important implications for understanding the interfacial charge-transfer mechanism of hybrid systems and related phenomena.« less

  5. Understanding the Charge Transfer at the Interface of Electron Donors and Acceptors: TTF–TCNQ as an Example

    DOE PAGES

    Park, Changwon; Atalla, Viktor; Smith, Sean; ...

    2017-06-16

    Charge transfer between an electron donor and an electron acceptor is widely accepted as being independent of their relative configurations if the interaction between them is weak; however, the limit of this concept for an interacting system has not yet been well established. Our study of prototypical electron donor–acceptor molecules, tetrathiafulvalene–tetracyanoquinodimethane, using density functional theory based on an advanced functional, clearly demonstrates that for interacting molecules, their configurational arrangement is as important as their individual electronic properties in the asymptotic limit to determine the charge transfer direction. For the first time, we demonstrate that by changing their relative orientation, onemore » can reverse the charge transfer direction of the pair, causing the molecules to exchange roles as donor and acceptor. In conclusion, our theory has important implications for understanding the interfacial charge-transfer mechanism of hybrid systems and related phenomena.« less

  6. Dynamic Modulation of Radiative Heat Transfer beyond the Blackbody Limit.

    PubMed

    Ito, Kota; Nishikawa, Kazutaka; Miura, Atsushi; Toshiyoshi, Hiroshi; Iizuka, Hideo

    2017-07-12

    Dynamic control of electromagnetic heat transfer without changing mechanical configuration opens possibilities in intelligent thermal management in nanoscale systems. We confirmed by experiment that the radiative heat transfer is dynamically modulated beyond the blackbody limit. The near-field electromagnetic heat exchange mediated by phonon-polariton is controlled by the metal-insulator transition of tungsten-doped vanadium dioxide. The functionalized heat flux is transferred over an area of 1.6 cm 2 across a 370 nm gap, which is maintained by the microfabricated spacers and applied pressure. The uniformity of the gap is validated by optical interferometry, and the measured heat transfer is well modeled as the sum of the radiative and the parasitic conductive components. The presented methodology to form a nanometric gap with functional heat flux paves the way to the smart thermal management in various scenes ranging from highly integrated systems to macroscopic apparatus.

  7. Case Report: 35-Year Follow-up for Nonvascularized Toe Phalangeal Transfer for Multiple Digit Symbrachydactyly.

    PubMed

    Naran, Sanjay; Imbriglia, Joseph E

    2016-12-01

    Background: A case is discussed in which a young girl was born with symbrachydactyly of multiple digits in whom nonvascularized proximal toe phalanges were transferred to the aphalangic digits at the age of four. At 39 years of age, she presented incidentally to our clinic and was observed to have a very functional hand with mobile metacarpophalangeal joints in all reconstructed digits. Methods: We present a case report which is discussed in the context of long-term follow-up, and phalangeal growth in the absence of distraction, and a review of the current literature in regards to outcomes for this modality of treatment. Results: We document growth of the transplanted phalanges, despite surgery occurring after the reported optimum age of before 18 months, and the patient not undergoing distraction. The patient reported no donor site morbidity in regards to function or psychosocial impact. Furthermore, we observed active function at the metacarpophalangeal joints of all operated digits. Conclusions: We report the longest follow-up (35 years) following nonvascularized proximal toe phalangeal transfer for short finger type symbrachydactyly. We highlight the long-term functional outcome of nonvascularized toe phalangeal transfers, and present an overview of the current outcome literature for this type of procedure, advocating that nonvascularized toe phalangeal transfers remain a viable treatment option for select cases of symbrachydactyly.

  8. 17 CFR 240.17Ad-21T - Operational capability in a Year 2000 environment.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... cessation or transfer of these functions. (e)(1)(i) If you are a registered non-bank transfer agent that has... to every registered non-bank transfer agent that uses computers in the conduct of its business as a...., Washington, DC 20549-6628 Attention: Y2K Compliance. (d)(1) If you are a registered non-bank transfer agent...

  9. Determinants of Intent to Transfer among Black Male Community College Students: A Multinomial, Multi-Level Investigation of Student Engagement

    ERIC Educational Resources Information Center

    Wood, J. Luke; Palmer, Robert T.

    2016-01-01

    Background/Context: Transfer is a core function of community colleges; this is a critical point given that these institutions serve as the primary pathway into postsecondary education for Black men. However, too few Black men identify transfer as a primary goal and/or eventually transfer to a 4-year college or university.…

  10. 17 CFR 240.17Ad-21T - Operational capability in a Year 2000 environment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... cessation or transfer of these functions. (e)(1)(i) If you are a registered non-bank transfer agent that has... to every registered non-bank transfer agent that uses computers in the conduct of its business as a...., Washington, DC 20549-6628 Attention: Y2K Compliance. (d)(1) If you are a registered non-bank transfer agent...

  11. 17 CFR 240.17Ad-21T - Operational capability in a Year 2000 environment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... cessation or transfer of these functions. (e)(1)(i) If you are a registered non-bank transfer agent that has... to every registered non-bank transfer agent that uses computers in the conduct of its business as a...., Washington, DC 20549-6628 Attention: Y2K Compliance. (d)(1) If you are a registered non-bank transfer agent...

  12. Unstable Memories Create a High-Level Representation that Enables Learning Transfer.

    PubMed

    Mosha, Neechi; Robertson, Edwin M

    2016-01-11

    A memory is unstable, making it susceptible to interference and disruption, after its acquisition [1-4]. The function or possible benefit of a memory being unstable at its acquisition is not well understood. Potentially, instability may be critical for the communication between recently acquired memories, which would allow learning in one task to be transferred to the other subsequent task [1, 5]. Learning may be transferred between any memories that are unstable, even between different types of memory. Here, we test the link between a memory being unstable and the transfer of learning to a different type of memory task. We measured how learning in one task transferred to and thus improved learning in a subsequent task. There was transfer from a motor skill to a word list task and, vice versa, from a word list to a motor skill task. What was transferred was a high-level relationship between elements, rather than knowledge of the individual elements themselves. Memory instability was correlated with subsequent transfer, suggesting that transfer was related to the instability of the memory. Using different methods, we stabilized the initial memory, preventing it from being susceptible to interference, and found that these methods consistently prevented transfer to the subsequent memory task. This suggests that the transfer of learning across diverse tasks is due to a high-level representation that can only be formed when a memory is unstable. Our work has identified an important function of memory instability. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. An upper bound on the radius of a highly electrically conducting lunar core

    NASA Technical Reports Server (NTRS)

    Hobbs, B. A.; Hood, L. L.; Herbert, F.; Sonett, C. P.

    1983-01-01

    Parker's (1980) nonlinear inverse theory for the electromagnetic sounding problem is converted to a form suitable for analysis of lunar day-side transfer function data by: (1) transforming the solution in plane geometry to that in spherical geometry; and (2) transforming the theoretical lunar transfer function in the dipole limit to an apparent resistivity function. The theory is applied to the revised lunar transfer function data set of Hood et al. (1982), which extends in frequency from 10 to the -5th to 10 to the -3rd Hz. On the assumption that an iron-rich lunar core, whether molten or solid, can be represented by a perfect conductor at the minimum sampled frequency, an upper bound of 435 km on the maximum radius of such a core is calculated. This bound is somewhat larger than values of 360-375 km previously estimated from the same data set via forward model calculations because the prior work did not consider all possible mantle conductivity functions.

  14. Training Data Requirement for a Neural Network to Predict Aerodynamic Coefficients

    NASA Technical Reports Server (NTRS)

    Korsmeyer, David (Technical Monitor); Rajkumar, T.; Bardina, Jorge

    2003-01-01

    Basic aerodynamic coefficients are modeled as functions of angle of attack, speed brake deflection angle, Mach number, and side slip angle. Most of the aerodynamic parameters can be well-fitted using polynomial functions. We previously demonstrated that a neural network is a fast, reliable way of predicting aerodynamic coefficients. We encountered few under fitted and/or over fitted results during prediction. The training data for the neural network are derived from wind tunnel test measurements and numerical simulations. The basic questions that arise are: how many training data points are required to produce an efficient neural network prediction, and which type of transfer functions should be used between the input-hidden layer and hidden-output layer. In this paper, a comparative study of the efficiency of neural network prediction based on different transfer functions and training dataset sizes is presented. The results of the neural network prediction reflect the sensitivity of the architecture, transfer functions, and training dataset size.

  15. Charge Transfer Directed Radical Substitution Enables para-Selective C–H Functionalization

    PubMed Central

    Boursalian, Gregory B.; Ham, Won Seok; Mazzotti, Anthony R.; Ritter, Tobias

    2016-01-01

    Efficient C–H functionalization requires selectivity for specific C–H bonds. Progress has been made for directed aromatic substitution reactions to achieve ortho- and meta- selectivity, but a general strategy for para-selective C–H functionalization has remained elusive. Herein, we introduce a previously unappreciated concept which enables nearly complete para selectivity. We propose that radicals with high electron affinity elicit areneto-radical charge transfer in the transition state of radical addition, which is the factor primarily responsible for high positional selectivity. We demonstrate that the selectivity is predictable by a simple theoretical tool and show the utility of the concept through a direct synthesis of aryl piperazines. Our results contradict the notion, widely held by organic chemists, that radical aromatic substitution reactions are inherently unselective. The concept of charge transfer directed radical substitution could serve as the basis for the development of new, highly selective C–H functionalization reactions. PMID:27442288

  16. Autoantibody-mediated bowel and bladder dysfunction in a patient with chronic, nondiabetic neuropathy.

    PubMed

    Jackson, Michael W; Gordon, Thomas P; McCombe, Pamela A

    2008-04-01

    Physiological techniques can be used to detect novel autoantibodies causing alteration of autonomic function after passive transfer to mice. Previously, such antibodies have been detected in patients with type I diabetes mellitus, myasthenia gravis, and Sjogren's syndrome. We now describe a patient with an idiopathic nondiabetic neuropathy with prominent autonomic symptoms, including bladder and bowel dysfunction. Physiological assays of whole colon and bladder were used to determine the presence in the patient serum of functional autoantibodies capable of mediating autonomic dysfunction. Immunoglobulin G (IgG) from this patient was able to disrupt bladder and bowel function on passive transfer to mice. This is a new pattern of autoantibody-mediated abnormality. Although the target antigen is unknown, it is likely to be a cell-surface receptor or ion channel. This case highlights the usefulness of passive transfer studies in detecting functional antibodies in patients with autonomic neuropathy.

  17. Charge-transfer-directed radical substitution enables para-selective C-H functionalization

    NASA Astrophysics Data System (ADS)

    Boursalian, Gregory B.; Ham, Won Seok; Mazzotti, Anthony R.; Ritter, Tobias

    2016-08-01

    Efficient C-H functionalization requires selectivity for specific C-H bonds. Progress has been made for directed aromatic substitution reactions to achieve ortho and meta selectivity, but a general strategy for para-selective C-H functionalization has remained elusive. Herein we introduce a previously unappreciated concept that enables nearly complete para selectivity. We propose that radicals with high electron affinity elicit arene-to-radical charge transfer in the transition state of radical addition, which is the factor primarily responsible for high positional selectivity. We demonstrate with a simple theoretical tool that the selectivity is predictable and show the utility of the concept through a direct synthesis of aryl piperazines. Our results contradict the notion, widely held by organic chemists, that radical aromatic substitution reactions are inherently unselective. The concept of radical substitution directed by charge transfer could serve as the basis for the development of new, highly selective C-H functionalization reactions.

  18. Effect of filter type on the statistics of energy transfer between resolved and subfilter scales from a-priori analysis of direct numerical simulations of isotropic turbulence

    NASA Astrophysics Data System (ADS)

    Buzzicotti, M.; Linkmann, M.; Aluie, H.; Biferale, L.; Brasseur, J.; Meneveau, C.

    2018-02-01

    The effects of different filtering strategies on the statistical properties of the resolved-to-subfilter scale (SFS) energy transfer are analysed in forced homogeneous and isotropic turbulence. We carry out a-priori analyses of the statistical characteristics of SFS energy transfer by filtering data obtained from direct numerical simulations with up to 20483 grid points as a function of the filter cutoff scale. In order to quantify the dependence of extreme events and anomalous scaling on the filter, we compare a sharp Fourier Galerkin projector, a Gaussian filter and a novel class of Galerkin projectors with non-sharp spectral filter profiles. Of interest is the importance of Galilean invariance and we confirm that local SFS energy transfer displays intermittency scaling in both skewness and flatness as a function of the cutoff scale. Furthermore, we quantify the robustness of scaling as a function of the filtering type.

  19. Hybrid fusions show that inter-monomer electron transfer robustly supports cytochrome bc{sub 1} function in vivo

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ekiert, Robert; Czapla, Monika; Sarewicz, Marcin

    2014-08-22

    Highlights: • We used hybrid fusion bc{sub 1} complex to test inter-monomer electron transfer in vivo. • Cross-inactivated complexes were able to sustain photoheterotrophic growth. • Inter-monomer electron transfer supports catalytic cycle in vivo. • bc{sub 1} dimer is functional even when cytochrome b subunits come from different species. - Abstract: Electronic connection between Q{sub o} and Q{sub i} quinone catalytic sites of dimeric cytochrome bc{sub 1} is a central feature of the energy-conserving Q cycle. While both the intra- and inter-monomer electron transfers were shown to connect the sites in the enzyme, mechanistic and physiological significance of the lattermore » remains unclear. Here, using a series of mutated hybrid cytochrome bc{sub 1}-like complexes, we show that inter-monomer electron transfer robustly sustains the function of the enzyme in vivo, even when the two subunits in a dimer come from different species. This indicates that minimal requirement for bioenergetic efficiency is to provide a chain of cofactors for uncompromised electron flux between the catalytic sites, while the details of protein scaffold are secondary.« less

  20. Heat Transfer Performance of Functionalized Graphene Nanoplatelet Aqueous Nanofluids

    PubMed Central

    Agromayor, Roberto; Cabaleiro, David; Pardinas, Angel A.; Vallejo, Javier P.; Fernandez-Seara, Jose; Lugo, Luis

    2016-01-01

    The low thermal conductivity of fluids used in many industrial applications is one of the primary limitations in the development of more efficient heat transfer systems. A promising solution to this problem is the suspension of nanoparticles with high thermal conductivities in a base fluid. These suspensions, known as nanofluids, have great potential for enhancing heat transfer. The heat transfer enhancement of sulfonic acid-functionalized graphene nanoplatelet water-based nanofluids is addressed in this work. A new experimental setup was designed for this purpose. Convection coefficients, pressure drops, and thermophysical properties of various nanofluids at different concentrations were measured for several operational conditions and the results are compared with those of pure water. Enhancements in thermal conductivity and in convection heat transfer coefficient reach 12% (1 wt %) and 32% (0.5 wt %), respectively. New correlations capable of predicting the Nusselt number and the friction factor of this kind of nanofluid as a function of other dimensionless quantities are developed. In addition, thermal performance factors are obtained from the experimental convection coefficient and pressure drop data in order to assess the convenience of replacing the base fluid with designed nanofluids. PMID:28773578

  1. Network Interface Specification for the T1 Microprocessor

    DTIC Science & Technology

    1994-05-01

    features data transfer directly to/from processor registers, hardware dispatch directly to Active Message handlers (along with limited context...Implementation Choices 9 3.1 Overview .................................... 9 3.2 Context ..................................... 10 3.3 Data Transfer...details of the data transfer functional units, interconnect structure, and network operation. Application Layer Communication Model Communication

  2. [A new prison health care model: the experience of the Basque Country].

    PubMed

    Zulaika, D; Etxeandia, P; Bengoa, A; Caminos, J; Arroyo-Cobo, J M

    2012-02-01

    A year after the transfer of prison health care functions and services from the State Administration to the Autonomous Community of the Basque Country, the process up to completion of the transfer, the current status of the transferred services and remaining challenges are described.

  3. Radiative heat transfer in strongly forward scattering media using the discrete ordinates method

    NASA Astrophysics Data System (ADS)

    Granate, Pedro; Coelho, Pedro J.; Roger, Maxime

    2016-03-01

    The discrete ordinates method (DOM) is widely used to solve the radiative transfer equation, often yielding satisfactory results. However, in the presence of strongly forward scattering media, this method does not generally conserve the scattering energy and the phase function asymmetry factor. Because of this, the normalization of the phase function has been proposed to guarantee that the scattering energy and the asymmetry factor are conserved. Various authors have used different normalization techniques. Three of these are compared in the present work, along with two other methods, one based on the finite volume method (FVM) and another one based on the spherical harmonics discrete ordinates method (SHDOM). In addition, the approximation of the Henyey-Greenstein phase function by a different one is investigated as an alternative to the phase function normalization. The approximate phase function is given by the sum of a Dirac delta function, which accounts for the forward scattering peak, and a smoother scaled phase function. In this study, these techniques are applied to three scalar radiative transfer test cases, namely a three-dimensional cubic domain with a purely scattering medium, an axisymmetric cylindrical enclosure containing an emitting-absorbing-scattering medium, and a three-dimensional transient problem with collimated irradiation. The present results show that accurate predictions are achieved for strongly forward scattering media when the phase function is normalized in such a way that both the scattered energy and the phase function asymmetry factor are conserved. The normalization of the phase function may be avoided using the FVM or the SHDOM to evaluate the in-scattering term of the radiative transfer equation. Both methods yield results whose accuracy is similar to that obtained using the DOM along with normalization of the phase function. Very satisfactory predictions were also achieved using the delta-M phase function, while the delta-Eddington phase function and the transport approximation may perform poorly.

  4. Methodology Investigation of AI(Artificial Intelligence) Test Officer Support Tool. Volume 2

    DTIC Science & Technology

    1989-03-01

    a mathematical representation of a PE and its connections. This representation describes the " neurodynamics " of a PE. A sigmoid transfer function is...Element(i) Neurodynamics : Summation Function: Wo*XO + W,*X + W*X "X 0 0 1 1 2 W~fn Transfer Function: F(k) = (1 + e k) Output: x. - F(I) Figure 2-4...simplifies the description of the network operations. Thus, one or more PEs grouped together, with the same neurodynamics , is a layer [reference 5]. A

  5. An Electrophysiological Investigation of Interhemispheric Transfer Time in Children and Adolescents with High-Functioning Autism Spectrum Disorders

    ERIC Educational Resources Information Center

    Clawson, Ann; Clayson, Peter E.; South, Mikle; Bigler, Erin D.; Larson, Michael J.

    2015-01-01

    Little is known about the functional impact of putative deficits in white-matter connectivity across the corpus callosum (CC) in individuals with autism spectrum disorders (ASDs). We utilized the temporal sensitivity of event-related potentials to examine the interhemispheric transfer time (IHTT) of basic visual information across the CC in youth…

  6. Transfer Function of Multi-Stage Active Filters: A Solution Based on Pascal's Triangle and a General Expression

    ERIC Educational Resources Information Center

    Levesque, Luc

    2012-01-01

    A method is proposed to simplify analytical computations of the transfer function for electrical circuit filters, which are made from repetitive identical stages. A method based on the construction of Pascal's triangle is introduced and then a general solution from two initial conditions is provided for the repetitive identical stage. The present…

  7. Transfer function tests of the Joy longwall shearer

    NASA Technical Reports Server (NTRS)

    Fisher, P. H., Jr.

    1978-01-01

    A series of operational tests was performed on the Joy longwall shearer located at the Bureau of Mines in Bructon, Pennsylvania. The purpose of these tests was to determine the transfer function and operational characteristics of the system. These characteristics will be used to generate a simulation model of the longwall shearer used in the development of the closed-loop vertical control system.

  8. How Toddlers Acquire and Transfer Tool Knowledge: Developmental Changes and the Role of Executive Functions

    ERIC Educational Resources Information Center

    Pauen, Sabina; Bechtel-Kuehne, Sabrina

    2016-01-01

    This report investigates tool learning and its relations to executive functions (EFs) in toddlers. In Study 1 (N = 93), 18-, 20-, 22-, and 24-month-old children learned equally well to choose a correct tool from observation, whereas performance based on feedback improved with age. Knowledge transfer showed significant progress after 22 months of…

  9. Cumulant generating function formula of heat transfer in ballistic systems with lead-lead coupling and general nonlinear systems

    NASA Astrophysics Data System (ADS)

    Li, Huanan

    2013-03-01

    Based on a two-time observation protocol, we consider heat transfer in a given time interval tM in a lead-junction-lead system taking coupling between the leads into account. In view of the two-time observation, consistency conditions are carefully verified in our specific family of quantum histories. Furthermore, its implication is briefly explored. Then using the nonequilibrium Green's function method, we obtain an exact formula for the cumulant generating function for heat transfer between the two leads, valid in both transient and steady-state regimes. Also, a compact formula for the cumulant generating function in the long-time limit is derived, for which the Gallavotti-Cohen fluctuation symmetry is explicitly verified. In addition, we briefly discuss Di Ventra's repartitioning trick regarding whether the repartitioning procedure of the total Hamiltonian affects the nonequilibrium steady-state current fluctuation. All kinds of properties of nonequilibrium current fluctuations, such as the fluctuation theorem in different time regimes, could be readily given according to these exact formulas. Finally a practical formalism dealing with cumulants of heat transfer across general nonlinear quantum systems is established based on field theoretical/algebraic method.

  10. Regional climate change predictions from the Goddard Institute for Space Studies high resolution GCM

    NASA Technical Reports Server (NTRS)

    Crane, Robert G.; Hewitson, B. C.

    1991-01-01

    A new diagnostic tool is developed for examining relationships between the synoptic scale circulation and regional temperature distributions in GCMs. The 4 x 5 deg GISS GCM is shown to produce accurate simulations of the variance in the synoptic scale sea level pressure distribution over the U.S. An analysis of the observational data set from the National Meteorological Center (NMC) also shows a strong relationship between the synoptic circulation and grid point temperatures. This relationship is demonstrated by deriving transfer functions between a time-series of circulation parameters and temperatures at individual grid points. The circulation parameters are derived using rotated principal components analysis, and the temperature transfer functions are based on multivariate polynomial regression models. The application of these transfer functions to the GCM circulation indicates that there is considerable spatial bias present in the GCM temperature distributions. The transfer functions are also used to indicate the possible changes in U.S. regional temperatures that could result from differences in synoptic scale circulation between a 1XCO2 and a 2xCO2 climate, using a doubled CO2 version of the same GISS GCM.

  11. Detector Apparatus and Method

    NASA Technical Reports Server (NTRS)

    Arndt, G. Dickey (Inventor); Ngo, Phong H. (Inventor); Carl, James R. (Inventor); Byerly, Kent A. (Inventor); Dusl, John (Inventor)

    2003-01-01

    Transceiver and methods are included that are especially suitable for detecting metallic materials, such as metallic mines, within an environment. The transceiver includes a digital waveform generator used to transmit a signal into the environment and a receiver that produces a digital received signal. A tracking module preferably compares an in-phase and quadrature transmitted signal with an in-phase and quadrature received signal to produce a spectral transfer function of the magnetic transceiver over a selected range of frequencies. The transceiver initially preferably creates a reference transfer function which is then stored in a memory. Subsequently measured transfer functions will vary depending on the presence of metal in the environment which was not in the environment when the reference transfer function was determined. The system may be utilized in the presence of other antennas, metal, and electronics which may comprise a plastic mine detector for detecting plastic mines. Despite the additional antennas and other metallic materials that may be in the environment due to the plastic mine detector, the magnetic transceiver remains highly sensitive to metallic material which may be located in various portions of the environment and which may be detected by sweeping the detector over ground that may contain metals or mines.

  12. Communication: Correct charge transfer in CT complexes from the Becke'05 density functional

    NASA Astrophysics Data System (ADS)

    Becke, Axel D.; Dale, Stephen G.; Johnson, Erin R.

    2018-06-01

    It has been known for over twenty years that density functionals of the generalized-gradient approximation (GGA) type and exact-exchange-GGA hybrids with low exact-exchange mixing fraction yield enormous errors in the properties of charge-transfer (CT) complexes. Manifestations of this error have also plagued computations of CT excitation energies. GGAs transfer far too much charge in CT complexes. This error has therefore come to be called "delocalization" error. It remains, to this day, a vexing unsolved problem in density-functional theory (DFT). Here we report that a 100% exact-exchange-based density functional known as Becke'05 or "B05" [A. D. Becke, J. Chem. Phys. 119, 2972 (2003); 122, 064101 (2005)] predicts excellent charge transfers in classic CT complexes involving the electron donors NH3, C2H4, HCN, and C2H2 and electron acceptors F2 and Cl2. Our approach is variational, as in our recent "B05min" dipole moments paper [Dale et al., J. Chem. Phys. 147, 154103 (2017)]. Therefore B05 is not only an accurate DFT for thermochemistry but is promising as a solution to the delocalization problem as well.

  13. [Cloning, mutagenesis and symbiotic phenotype of three lipid transfer protein encoding genes from Mesorhizobium huakuii 7653R].

    PubMed

    Li, Yanan; Zeng, Xiaobo; Zhou, Xuejuan; Li, Youguo

    2016-12-04

    Lipid transfer protein superfamily is involved in lipid transport and metabolism. This study aimed to construct mutants of three lipid transfer protein encoding genes in Mesorhizobium huakuii 7653R, and to study the phenotypes and function of mutations during symbiosis with Astragalus sinicus. We used bioinformatics to predict structure characteristics and biological functions of lipid transfer proteins, and conducted semi-quantitative and fluorescent quantitative real-time PCR to analyze the expression levels of target genes in free-living and symbiotic conditions. Using pK19mob insertion mutagenesis to construct mutants, we carried out pot plant experiments to observe symbiotic phenotypes. MCHK-5577, MCHK-2172 and MCHK-2779 genes encoding proteins belonged to START/RHO alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) superfamily, involved in lipid transport or metabolism, and were identical to M. loti at 95% level. Gene relative transcription level of the three genes all increased compared to free-living condition. We obtained three mutants. Compared with wild-type 7653R, above-ground biomass of plants and nodulenitrogenase activity induced by the three mutants significantly decreased. Results indicated that lipid transfer protein encoding genes of Mesorhizobium huakuii 7653R may play important roles in symbiotic nitrogen fixation, and the mutations significantly affected the symbiotic phenotypes. The present work provided a basis to study further symbiotic function mechanism associated with lipid transfer proteins from rhizobia.

  14. Application of Degenerately Doped Metal Oxides in the Study of Photoinduced Interfacial Electron Transfer.

    PubMed

    Farnum, Byron H; Morseth, Zachary A; Brennaman, M Kyle; Papanikolas, John M; Meyer, Thomas J

    2015-06-18

    Degenerately doped In2O3:Sn semiconductor nanoparticles (nanoITO) have been used to study the photoinduced interfacial electron-transfer reactivity of surface-bound [Ru(II)(bpy)2(4,4'-(PO3H2)2-bpy)](2+) (RuP(2+)) molecules as a function of driving force over a range of 1.8 eV. The metallic properties of the ITO nanoparticles, present within an interconnected mesoporous film, allowed for the driving force to be tuned by controlling their Fermi level with an external bias while their optical transparency allowed for transient absorption spectroscopy to be used to monitor electron-transfer kinetics. Photoinduced electron transfer from excited-state -RuP(2+*) molecules to nanoITO was found to be dependent on applied bias and competitive with nonradiative energy transfer to nanoITO. Back electron transfer from nanoITO to oxidized -RuP(3+) was also dependent on the applied bias but without complication from inter- or intraparticle electron diffusion in the oxide nanoparticles. Analysis of the electron injection kinetics as a function of driving force using Marcus-Gerischer theory resulted in an experimental estimate of the reorganization energy for the excited-state -RuP(3+/2+*) redox couple of λ* = 0.83 eV and an electronic coupling matrix element, arising from electronic wave function overlap between the donor orbital in the molecule and the acceptor orbital(s) in the nanoITO electrode, of Hab = 20-45 cm(-1). Similar analysis of the back electron-transfer kinetics yielded λ = 0.56 eV for the ground-state -RuP(3+/2+) redox couple and Hab = 2-4 cm(-1). The use of these wide band gap, degenerately doped materials provides a unique experimental approach for investigating single-site electron transfer at the surface of oxide nanoparticles.

  15. High Temperature Gas Energy Transfer.

    DTIC Science & Technology

    1982-08-15

    will be made. A theoretical model has been applied to the calculation of energy transfer amounts between molecules as a function of molecular size... theoretical analysis was given of shock tube data for high temperature gas reactions. The data were analyzed to show that colli- sional energy transfer...Systems by I. Oref and B. S. Rabiovitch. In this report a simple theoretical model describing energy transfer probabilities is given. Conservation of

  16. Context transfer in reinforcement learning using action-value functions.

    PubMed

    Mousavi, Amin; Nadjar Araabi, Babak; Nili Ahmadabadi, Majid

    2014-01-01

    This paper discusses the notion of context transfer in reinforcement learning tasks. Context transfer, as defined in this paper, implies knowledge transfer between source and target tasks that share the same environment dynamics and reward function but have different states or action spaces. In other words, the agents learn the same task while using different sensors and actuators. This requires the existence of an underlying common Markov decision process (MDP) to which all the agents' MDPs can be mapped. This is formulated in terms of the notion of MDP homomorphism. The learning framework is Q-learning. To transfer the knowledge between these tasks, the feature space is used as a translator and is expressed as a partial mapping between the state-action spaces of different tasks. The Q-values learned during the learning process of the source tasks are mapped to the sets of Q-values for the target task. These transferred Q-values are merged together and used to initialize the learning process of the target task. An interval-based approach is used to represent and merge the knowledge of the source tasks. Empirical results show that the transferred initialization can be beneficial to the learning process of the target task.

  17. Structural development of wheat nutrient transfer tissues and their relationships with filial tissues development.

    PubMed

    Xurun, Yu; Xinyu, Chen; Liang, Zhou; Jing, Zhang; Heng, Yu; Shanshan, Shao; Fei, Xiong; Zhong, Wang

    2015-03-01

    Nutrients from spikelet phloem are commonly delivered to endosperm via caryopsis nutrient transfer tissues (NTTs). Elucidation of NTTs development is paramount to developing an understanding of the control of assimilate partitioning. Little information was available on the structural development of the entire NTTs and their functions, particularly those involved in the relationship between development of NTTs and growth of filial tissues including endosperm and embryo. In this study, wheat caryopses at different development stages were collected for observation of the NTTs by light microscopy, stereoscopic microscopy, and scanning electron microscopy. The cytological features of NTTs in the developing wheat caryopsis were clearly elucidated. The results were as follows: NTTs in the wheat caryopsis include maternal transfer tissues that are composed of vascular bundle, chalaza and nucellar projection transfer cells, and endosperm transfer tissues that consist of the aleurone transfer cells, starchy endosperm transfer cells, and endosperm conducting cells. The initiation, development, and apoptosis of these NTTs revealed the pattern of temporal and spatial gradient and were closely coordinated with endosperm and embryo development. These results may give us a further understanding about the functions of NTTs and their relationships with endosperm and embryo development.

  18. Context Transfer in Reinforcement Learning Using Action-Value Functions

    PubMed Central

    Mousavi, Amin; Nadjar Araabi, Babak; Nili Ahmadabadi, Majid

    2014-01-01

    This paper discusses the notion of context transfer in reinforcement learning tasks. Context transfer, as defined in this paper, implies knowledge transfer between source and target tasks that share the same environment dynamics and reward function but have different states or action spaces. In other words, the agents learn the same task while using different sensors and actuators. This requires the existence of an underlying common Markov decision process (MDP) to which all the agents' MDPs can be mapped. This is formulated in terms of the notion of MDP homomorphism. The learning framework is Q-learning. To transfer the knowledge between these tasks, the feature space is used as a translator and is expressed as a partial mapping between the state-action spaces of different tasks. The Q-values learned during the learning process of the source tasks are mapped to the sets of Q-values for the target task. These transferred Q-values are merged together and used to initialize the learning process of the target task. An interval-based approach is used to represent and merge the knowledge of the source tasks. Empirical results show that the transferred initialization can be beneficial to the learning process of the target task. PMID:25610457

  19. Reliable Control Using Disturbance Observer and Equivalent Transfer Function for Position Servo System in Current Feedback Loop Failure

    NASA Astrophysics Data System (ADS)

    Ishikawa, Kaoru; Nakamura, Taro; Osumi, Hisashi

    A reliable control method is proposed for multiple loop control system. After a feedback loop failure, such as case of the sensor break down, the control system becomes unstable and has a big fluctuation even if it has a disturbance observer. To cope with this problem, the proposed method uses an equivalent transfer function (ETF) as active redundancy compensation after the loop failure. The ETF is designed so that it does not change the transfer function of the whole system before and after the loop failure. In this paper, the characteristic of reliable control system that uses an ETF and a disturbance observer is examined by the experiment that uses the DC servo motor for the current feedback loop failure in the position servo system.

  20. Shear mode ER transfer function for robotic applications

    NASA Astrophysics Data System (ADS)

    Tan, K. P.; Stanway, R.; Bullough, W. A.

    2005-06-01

    Electro-rheological (ER) fluids are becoming popular in modern industrial applications. The advantage of employing ER devices is due to the ease of energizing the ER fluids at fast speeds of response. One innovation in ER applications could be in the positioning control of the robotic arm using an ER clutch. In order to actuate the manipulator, the ER output torque response is required. However, the behaviour of this ER torque response at different input conditions is not clearly understood. Therefore, in this paper, a sample study of the ER output torque is conducted. The ER output torque responses at different input parameters are studied carefully for the establishment of an appropriate ER transfer function in shear mode. This transfer function will serve as an important feature in future ER-actuated robot arm's control process.

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