Sample records for transient anomalous subdiffusion

  1. Wanted: A Positive Control for Anomalous Subdiffusion

    PubMed Central

    Saxton, Michael J.

    2012-01-01

    Anomalous subdiffusion in cells and model systems is an active area of research. The main questions are whether diffusion is anomalous or normal, and if it is anomalous, its mechanism. The subject is controversial, especially the hypothesis that crowding causes anomalous subdiffusion. Anomalous subdiffusion measurements would be strengthened by an experimental standard, particularly one able to cross-calibrate the different types of measurements. Criteria for a calibration standard are proposed. First, diffusion must be anomalous over the length and timescales of the different measurements. The length-scale is fundamental; the time scale can be adjusted through the viscosity of the medium. Second, the standard must be theoretically well understood, with a known anomalous subdiffusion exponent, ideally readily tunable. Third, the standard must be simple, reproducible, and independently characterizable (by, for example, electron microscopy for nanostructures). Candidate experimental standards are evaluated, including obstructed lipid bilayers; aqueous systems obstructed by nanopillars; a continuum percolation system in which a prescribed fraction of randomly chosen obstacles in a regular array is ablated; single-file diffusion in pores; transient anomalous subdiffusion due to binding of particles in arrays such as transcription factors in randomized DNA arrays; and computer-generated physical trajectories. PMID:23260043

  2. Probing the type of anomalous diffusion with single-particle tracking.

    PubMed

    Ernst, Dominique; Köhler, Jürgen; Weiss, Matthias

    2014-05-07

    Many reactions in complex fluids, e.g. signaling cascades in the cytoplasm of living cells, are governed by a diffusion-driven encounter of reactants. Yet, diffusion in complex fluids often exhibits an anomalous characteristic ('subdiffusion'). Since different types of subdiffusion have distinct effects on timing and equilibria of chemical reactions, a thorough determination of the reactants' type of random walk is key to a quantitative understanding of reactions in complex fluids. Here we introduce a straightforward and simple approach for determining the type of subdiffusion from single-particle tracking data. Unlike previous approaches, our method also is sensitive to transient subdiffusion phenomena, e.g. obstructed diffusion below the percolation threshold. We validate our strategy with data from experiment and simulation.

  3. Anomalous diffusion due to hindering by mobile obstacles undergoing Brownian motion or Orstein-Ulhenbeck processes.

    PubMed

    Berry, Hugues; Chaté, Hugues

    2014-02-01

    In vivo measurements of the passive movements of biomolecules or vesicles in cells consistently report "anomalous diffusion," where mean-squared displacements scale as a power law of time with exponent α<1 (subdiffusion). While the detailed mechanisms causing such behaviors are not always elucidated, movement hindrance by obstacles is often invoked. However, our understanding of how hindered diffusion leads to subdiffusion is based on diffusion amidst randomly located immobile obstacles. Here, we have used Monte Carlo simulations to investigate transient subdiffusion due to mobile obstacles with various modes of mobility. Our simulations confirm that the anomalous regimes rapidly disappear when the obstacles move by Brownian motion. By contrast, mobile obstacles with more confined displacements, e.g., Orstein-Ulhenbeck motion, are shown to preserve subdiffusive regimes. The mean-squared displacement of tracked protein displays convincing power laws with anomalous exponent α that varies with the density of Orstein-Ulhenbeck (OU) obstacles or the relaxation time scale of the OU process. In particular, some of the values we observed are significantly below the universal value predicted for immobile obstacles in two dimensions. Therefore, our results show that subdiffusion due to mobile obstacles with OU type of motion may account for the large variation range exhibited by experimental measurements in living cells and may explain that some experimental estimates are below the universal value predicted for immobile obstacles.

  4. Anomalous subdiffusion in fluorescence photobleaching recovery: a Monte Carlo study.

    PubMed Central

    Saxton, M J

    2001-01-01

    Anomalous subdiffusion is hindered diffusion in which the mean-square displacement of a diffusing particle is proportional to some power of time less than one. Anomalous subdiffusion has been observed for a variety of lipids and proteins in the plasma membranes of a variety of cells. Fluorescence photobleaching recovery experiments with anomalous subdiffusion are simulated to see how to analyze the data. It is useful to fit the recovery curve with both the usual recovery equation and the anomalous one, and to judge the goodness of fit on log-log plots. The simulations show that the simplest approximate treatment of anomalous subdiffusion usually gives good results. Three models of anomalous subdiffusion are considered: obstruction, fractional Brownian motion, and the continuous-time random walk. The models differ significantly in their behavior at short times and in their noise level. For obstructed diffusion the approach to the percolation threshold is marked by a large increase in noise, a broadening of the distribution of diffusion coefficients and anomalous subdiffusion exponents, and the expected abrupt decrease in the mobile fraction. The extreme fluctuations in the recovery curves at and near the percolation threshold result from extreme fluctuations in the geometry of the percolation cluster. PMID:11566793

  5. Concentration-Encoded Subdiffusive Molecular Communication: Theory, Channel Characteristics, and Optimum Signal Detection.

    PubMed

    Mahfuz, Mohammad Upal; Makrakis, Dimitrios; Mouftah, Hussein T

    2016-09-01

    Unlike normal diffusion, in anomalous diffusion, the movement of a molecule is described by the correlated random walk model where the mean square displacement of a molecule depends on the power law of time. In molecular communication (MC), there are many scenarios when the propagation of molecules cannot be described by normal diffusion process, where anomalous diffusion is a better fit. In this paper, the effects of anomalous subdiffusion on concentration-encoded molecular communication (CEMC) are investigated. Although classical (i.e., normal) diffusion is a widely-used model of diffusion in molecular communication (MC) research, anomalous subdiffusion is quite common in biological media involving bio-nanomachines, yet inadequately addressed as a research issue so far. Using the fractional diffusion approach, the molecular propagation effects in the case of pure subdiffusion occurring in an unbounded three-dimensional propagation medium have been shown in detail in terms of temporal dispersion parameters of the impulse response of the subdiffusive channel. Correspondingly, the bit error rate (BER) performance of a CEMC system is investigated with sampling-based (SD) and strength (i.e., energy)-based (ED) signal detection methods. It is found that anomalous subdiffusion has distinctive time-dispersive properties that play a vital role in accurately designing a subdiffusive CEMC system. Unlike normal diffusion, to detect information symbols in subdiffusive CEMC, a receiver requires larger memory size to operate correctly and hence a more complex structure. An in-depth analysis has been made on the performances of SD and ED optimum receiver models under diffusion noise and intersymbol interference (ISI) scenarios when communication range, transmission data rate, and memory size vary. In subdiffusive CEMC, the SD method.

  6. Transport equations for subdiffusion with nonlinear particle interaction.

    PubMed

    Straka, P; Fedotov, S

    2015-02-07

    We show how the nonlinear interaction effects 'volume filling' and 'adhesion' can be incorporated into the fractional subdiffusive transport of cells and individual organisms. To this end, we use microscopic random walk models with anomalous trapping and systematically derive generic non-Markovian and nonlinear governing equations for the mean concentrations of the subdiffusive cells or organisms. We uncover an interesting interaction between the nonlinearities and the non-Markovian nature of the transport. In the subdiffusive case, this interaction manifests itself in a nontrivial combination of nonlinear terms with fractional derivatives. In the long time limit, however, these equations simplify to a form without fractional operators. This provides an easy method for the study of aggregation phenomena. In particular, this enables us to show that volume filling can prevent "anomalous aggregation," which occurs in subdiffusive systems with a spatially varying anomalous exponent. Copyright © 2014 Elsevier Ltd. All rights reserved.

  7. Viscoelastic subdiffusion: from anomalous to normal.

    PubMed

    Goychuk, Igor

    2009-10-01

    We study viscoelastic subdiffusion in bistable and periodic potentials within the generalized Langevin equation approach. Our results justify the (ultra)slow fluctuating rate view of the corresponding bistable non-Markovian dynamics which displays bursting and anticorrelation of the residence times in two potential wells. The transition kinetics is asymptotically stretched exponential when the potential barrier V0 several times exceeds thermal energy k(B)T [V(0) approximately (2-10)k(B)T] and it cannot be described by the non-Markovian rate theory (NMRT). The well-known NMRT result approximates, however, ever better with the increasing barrier height, the most probable logarithm of the residence times. Moreover, the rate description is gradually restored when the barrier height exceeds a fuzzy borderline which depends on the power-law exponent of free subdiffusion alpha . Such a potential-free subdiffusion is ergodic. Surprisingly, in periodic potentials it is not sensitive to the barrier height in the long time asymptotic limit. However, the transient to this asymptotic regime is extremally slow and it does profoundly depend on the barrier height. The time scale of such subdiffusion can exceed the mean residence time in a potential well or in a finite spatial domain by many orders of magnitude. All these features are in sharp contrast with an alternative subdiffusion mechanism involving jumps among traps with the divergent mean residence time in these traps.

  8. An anomalous subdiffusion model for calcium spark in cardiac myocytes

    NASA Astrophysics Data System (ADS)

    Tan, Wenchang; Fu, Chaoqi; Fu, Ceji; Xie, Wenjun; Cheng, Heping

    2007-10-01

    The elementary events of excitation-contraction coupling in heart muscle are Ca2+ sparks, which arise from ryanodine receptors in the sarcoplasmic reticulum (SR). Here, an anomalous subdiffusion model is developed to explore Ca2+ spark formation in cardiac myocytes. Numerical simulations reproduce the brightness, the time course, and spatial size of a typical cardiac Ca2+ spark. It is suggested that the diffusion of Ca2+ spark in the cytoplasm may no longer obey Fickian second law, but the anomalous space subdiffusion. The physical reason is perhaps due to the effects of the electric field of the calcium ions and the viscoelasticity of the cytoplasm and its complex structures.

  9. Fractional cable equation models for anomalous electrodiffusion in nerve cells: infinite domain solutions.

    PubMed

    Langlands, T A M; Henry, B I; Wearne, S L

    2009-12-01

    We introduce fractional Nernst-Planck equations and derive fractional cable equations as macroscopic models for electrodiffusion of ions in nerve cells when molecular diffusion is anomalous subdiffusion due to binding, crowding or trapping. The anomalous subdiffusion is modelled by replacing diffusion constants with time dependent operators parameterized by fractional order exponents. Solutions are obtained as functions of the scaling parameters for infinite cables and semi-infinite cables with instantaneous current injections. Voltage attenuation along dendrites in response to alpha function synaptic inputs is computed. Action potential firing rates are also derived based on simple integrate and fire versions of the models. Our results show that electrotonic properties and firing rates of nerve cells are altered by anomalous subdiffusion in these models. We have suggested electrophysiological experiments to calibrate and validate the models.

  10. Generalized fractional diffusion equations for accelerating subdiffusion and truncated Lévy flights

    NASA Astrophysics Data System (ADS)

    Chechkin, A. V.; Gonchar, V. Yu.; Gorenflo, R.; Korabel, N.; Sokolov, I. M.

    2008-08-01

    Fractional diffusion equations are widely used to describe anomalous diffusion processes where the characteristic displacement scales as a power of time. For processes lacking such scaling the corresponding description may be given by diffusion equations with fractional derivatives of distributed order. Such equations were introduced in A. V. Chechkin, R. Gorenflo, and I. Sokolov [Phys. Rev. E 66, 046129 (2002)] for the description of the processes getting more anomalous in the course of time (decelerating subdiffusion and accelerating superdiffusion). Here we discuss the properties of diffusion equations with fractional derivatives of the distributed order for the description of anomalous relaxation and diffusion phenomena getting less anomalous in the course of time, which we call, respectively, accelerating subdiffusion and decelerating superdiffusion. For the former process, by taking a relatively simple particular example with two fixed anomalous diffusion exponents we show that the proposed equation effectively describes the subdiffusion phenomenon with diffusion exponent varying in time. For the latter process we demonstrate by a particular example how the power-law truncated Lévy stable distribution evolves in time to the distribution with power-law asymptotics and Gaussian shape in the central part. The special case of two different orders is characteristic for the general situation in which the extreme orders dominate the asymptotics.

  11. Anomalous versus Slowed-Down Brownian Diffusion in the Ligand-Binding Equilibrium

    PubMed Central

    Soula, Hédi; Caré, Bertrand; Beslon, Guillaume; Berry, Hugues

    2013-01-01

    Measurements of protein motion in living cells and membranes consistently report transient anomalous diffusion (subdiffusion) that converges back to a Brownian motion with reduced diffusion coefficient at long times after the anomalous diffusion regime. Therefore, slowed-down Brownian motion could be considered the macroscopic limit of transient anomalous diffusion. On the other hand, membranes are also heterogeneous media in which Brownian motion may be locally slowed down due to variations in lipid composition. Here, we investigate whether both situations lead to a similar behavior for the reversible ligand-binding reaction in two dimensions. We compare the (long-time) equilibrium properties obtained with transient anomalous diffusion due to obstacle hindrance or power-law-distributed residence times (continuous-time random walks) to those obtained with space-dependent slowed-down Brownian motion. Using theoretical arguments and Monte Carlo simulations, we show that these three scenarios have distinctive effects on the apparent affinity of the reaction. Whereas continuous-time random walks decrease the apparent affinity of the reaction, locally slowed-down Brownian motion and local hindrance by obstacles both improve it. However, only in the case of slowed-down Brownian motion is the affinity maximal when the slowdown is restricted to a subregion of the available space. Hence, even at long times (equilibrium), these processes are different and exhibit irreconcilable behaviors when the area fraction of reduced mobility changes. PMID:24209851

  12. Plasma Membrane is Compartmentalized by a Self-Similar Cortical Actin Meshwork

    NASA Astrophysics Data System (ADS)

    Sadegh, Sanaz; Higgins, Jenny L.; Mannion, Patrick C.; Tamkun, Michael M.; Krapf, Diego

    2017-01-01

    A broad range of membrane proteins display anomalous diffusion on the cell surface. Different methods provide evidence for obstructed subdiffusion and diffusion on a fractal space, but the underlying structure inducing anomalous diffusion has never been visualized because of experimental challenges. We addressed this problem by imaging the cortical actin at high resolution while simultaneously tracking individual membrane proteins in live mammalian cells. Our data confirm that actin introduces barriers leading to compartmentalization of the plasma membrane and that membrane proteins are transiently confined within actin fences. Furthermore, superresolution imaging shows that the cortical actin is organized into a self-similar meshwork. These results present a hierarchical nanoscale picture of the plasma membrane.

  13. Anomalous versus slowed-down Brownian diffusion in the ligand-binding equilibrium.

    PubMed

    Soula, Hédi; Caré, Bertrand; Beslon, Guillaume; Berry, Hugues

    2013-11-05

    Measurements of protein motion in living cells and membranes consistently report transient anomalous diffusion (subdiffusion) that converges back to a Brownian motion with reduced diffusion coefficient at long times after the anomalous diffusion regime. Therefore, slowed-down Brownian motion could be considered the macroscopic limit of transient anomalous diffusion. On the other hand, membranes are also heterogeneous media in which Brownian motion may be locally slowed down due to variations in lipid composition. Here, we investigate whether both situations lead to a similar behavior for the reversible ligand-binding reaction in two dimensions. We compare the (long-time) equilibrium properties obtained with transient anomalous diffusion due to obstacle hindrance or power-law-distributed residence times (continuous-time random walks) to those obtained with space-dependent slowed-down Brownian motion. Using theoretical arguments and Monte Carlo simulations, we show that these three scenarios have distinctive effects on the apparent affinity of the reaction. Whereas continuous-time random walks decrease the apparent affinity of the reaction, locally slowed-down Brownian motion and local hindrance by obstacles both improve it. However, only in the case of slowed-down Brownian motion is the affinity maximal when the slowdown is restricted to a subregion of the available space. Hence, even at long times (equilibrium), these processes are different and exhibit irreconcilable behaviors when the area fraction of reduced mobility changes. Copyright © 2013 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  14. The Plasma Membrane is Compartmentalized by a Self-Similar Cortical Actin Fractal

    NASA Astrophysics Data System (ADS)

    Sadegh, Sanaz; Higgin, Jenny; Mannion, Patrick; Tamkun, Michael; Krapf, Diego

    A broad range of membrane proteins display anomalous diffusion on the cell surface. Different methods provide evidence for obstructed subdiffusion and diffusion on a fractal space, but the underlying structure inducing anomalous diffusion has never been visualized due to experimental challenges. We addressed this problem by imaging the cortical actin at high resolution while simultaneously tracking individual membrane proteins in live mammalian cells. Our data show that actin introduces barriers leading to compartmentalization of the plasma membrane and that membrane proteins are transiently confined within actin fences. Furthermore, superresolution imaging shows that the cortical actin is organized into a self-similar fractal. These results present a hierarchical nanoscale picture of the plasma membrane and demonstrate direct interactions between the actin cortex and the cell surface.

  15. Tracking single Kv2.1 channels in live cells reveals anomalous subdiffusion and ergodicity breaking

    NASA Astrophysics Data System (ADS)

    Weigel, Aubrey; Simon, Blair; Tamkun, Michael; Krapf, Diego

    2011-03-01

    The dynamic organization of the plasma membrane is responsible for essential cellular processes, such as receptor trafficking and signaling. By studying the dynamics of transmembrane proteins a greater understanding of these processes as a whole can be achieved. It is broadly observed that the diffusion pattern of membrane protein displays anomalous subdiffusion. However, the mechanisms responsible for this behavior are not yet established. We explore the dynamics of the voltage gated potassium channel Kv2.1 by using single-particle tracking. We analyze Kv2.1 channel trajectories in terms of the time and ensemble distributions of square displacements. Our results reveal that all Kv2.1 channels experience anomalous subdiffusion and we observe that the Kv2.1 diffusion pattern is non-ergodic. We further investigated the role of the actin cytoskeleton in these channel dynamics by applying actin depolymerizing drugs. It is seen that with the breakdown of the actin cytoskeleton the Kv2.1 channel trajectories recover ergodicity.

  16. Fractional Brownian motors and stochastic resonance

    NASA Astrophysics Data System (ADS)

    Goychuk, Igor; Kharchenko, Vasyl

    2012-05-01

    We study fluctuating tilt Brownian ratchets based on fractional subdiffusion in sticky viscoelastic media characterized by a power law memory kernel. Unlike the normal diffusion case, the rectification effect vanishes in the adiabatically slow modulation limit and optimizes in a driving frequency range. It is shown also that the anomalous rectification effect is maximal (stochastic resonance effect) at optimal temperature and can be of surprisingly good quality. Moreover, subdiffusive current can flow in the counterintuitive direction upon a change of temperature or driving frequency. The dependence of anomalous transport on load exhibits a remarkably simple universality.

  17. Anomalous Dynamics of a Lipid Recognition Protein on a Membrane Surface

    PubMed Central

    Yamamoto, Eiji; Kalli, Antreas C.; Akimoto, Takuma; Yasuoka, Kenji; Sansom, Mark S. P.

    2015-01-01

    Pleckstrin homology (PH) domains are lipid-binding modules present in peripheral membrane proteins which interact with phosphatidyl-inositol phosphates (PIPs) in cell membranes. We use multiscale molecular dynamics simulations to characterize the localization and anomalous dynamics of the DAPP1 PH domain on the surface of a PIP-containing lipid bilayer. Both translational and rotational diffusion of the PH domain on the lipid membrane surface exhibit transient subdiffusion, with an exponent α ≈ 0.5 for times of less than 10 ns. In addition to a PIP3 molecule at the canonical binding site of the PH domain, we observe additional PIP molecules in contact with the protein. Fluctuations in the number of PIPs associated with the PH domain exhibit 1/f noise. We suggest that the anomalous diffusion and long-term correlated interaction of the PH domain with the membrane may contribute to an enhanced probability of encounter with target complexes on cell membrane surfaces. PMID:26657413

  18. MESOSCOPIC MODELING OF STOCHASTIC REACTION-DIFFUSION KINETICS IN THE SUBDIFFUSIVE REGIME

    PubMed Central

    BLANC, EMILIE; ENGBLOM, STEFAN; HELLANDER, ANDREAS; LÖTSTEDT, PER

    2017-01-01

    Subdiffusion has been proposed as an explanation of various kinetic phenomena inside living cells. In order to fascilitate large-scale computational studies of subdiffusive chemical processes, we extend a recently suggested mesoscopic model of subdiffusion into an accurate and consistent reaction-subdiffusion computational framework. Two different possible models of chemical reaction are revealed and some basic dynamic properties are derived. In certain cases those mesoscopic models have a direct interpretation at the macroscopic level as fractional partial differential equations in a bounded time interval. Through analysis and numerical experiments we estimate the macroscopic effects of reactions under subdiffusive mixing. The models display properties observed also in experiments: for a short time interval the behavior of the diffusion and the reaction is ordinary, in an intermediate interval the behavior is anomalous, and at long times the behavior is ordinary again. PMID:29046618

  19. Nonlinear subdiffusive fractional equations and the aggregation phenomenon.

    PubMed

    Fedotov, Sergei

    2013-09-01

    In this article we address the problem of the nonlinear interaction of subdiffusive particles. We introduce the random walk model in which statistical characteristics of a random walker such as escape rate and jump distribution depend on the mean density of particles. We derive a set of nonlinear subdiffusive fractional master equations and consider their diffusion approximations. We show that these equations describe the transition from an intermediate subdiffusive regime to asymptotically normal advection-diffusion transport regime. This transition is governed by nonlinear tempering parameter that generalizes the standard linear tempering. We illustrate the general results through the use of the examples from cell and population biology. We find that a nonuniform anomalous exponent has a strong influence on the aggregation phenomenon.

  20. Divergent series and memory of the initial condition in the long-time solution of some anomalous diffusion problems.

    PubMed

    Yuste, S Bravo; Borrego, R; Abad, E

    2010-02-01

    We consider various anomalous d -dimensional diffusion problems in the presence of an absorbing boundary with radial symmetry. The motion of particles is described by a fractional diffusion equation. Their mean-square displacement is given by r(2) proportional, variant t(gamma)(00 , the emergence of such series in the long-time domain is a specific feature of subdiffusion problems. We present a method to regularize such series, and, in some cases, validate the procedure by using alternative techniques (Laplace transform method and numerical simulations). In the normal diffusion case, we find that the signature of the initial condition on the approach to the steady state rapidly fades away and the solution approaches a single (the main) decay mode in the long-time regime. In remarkable contrast, long-time memory of the initial condition is present in the subdiffusive case as the spatial part Psi1(r) describing the long-time decay of the solution to the steady state is determined by a weighted superposition of all spatial modes characteristic of the normal diffusion problem, the weight being dependent on the initial condition. Interestingly, Psi1(r) turns out to be independent of the anomalous diffusion exponent gamma .

  1. Anomalous Transport of High Energy Cosmic Rays in Galactic Superbubbles

    NASA Technical Reports Server (NTRS)

    Barghouty, Nasser F.

    2014-01-01

    High-energy cosmic rays may exhibit anomalous transport as they traverse and are accelerated by a collection of supernovae explosions in a galactic superbubble. Signatures of this anomalous transport can show up in the particles' evolution and their spectra. In a continuous-time-random- walk (CTRW) model assuming standard diffusive shock acceleration theory (DSA) for each shock encounter, and where the superbubble (an OB stars association) is idealized as a heterogeneous region of particle sources and sinks, acceleration and transport in the superbubble can be shown to be sub-diffusive. While the sub-diffusive transport can be attributed to the stochastic nature of the acceleration time according to DSA theory, the spectral break appears to be an artifact of transport in a finite medium. These CTRW simulations point to a new and intriguing phenomenon associated with the statistical nature of collective acceleration of high energy cosmic rays in galactic superbubbles.

  2. Langevin equation with fluctuating diffusivity: A two-state model

    NASA Astrophysics Data System (ADS)

    Miyaguchi, Tomoshige; Akimoto, Takuma; Yamamoto, Eiji

    2016-07-01

    Recently, anomalous subdiffusion, aging, and scatter of the diffusion coefficient have been reported in many single-particle-tracking experiments, though the origins of these behaviors are still elusive. Here, as a model to describe such phenomena, we investigate a Langevin equation with diffusivity fluctuating between a fast and a slow state. Namely, the diffusivity follows a dichotomous stochastic process. We assume that the sojourn time distributions of these two states are given by power laws. It is shown that, for a nonequilibrium ensemble, the ensemble-averaged mean-square displacement (MSD) shows transient subdiffusion. In contrast, the time-averaged MSD shows normal diffusion, but an effective diffusion coefficient transiently shows aging behavior. The propagator is non-Gaussian for short time and converges to a Gaussian distribution in a long-time limit; this convergence to Gaussian is extremely slow for some parameter values. For equilibrium ensembles, both ensemble-averaged and time-averaged MSDs show only normal diffusion and thus we cannot detect any traces of the fluctuating diffusivity with these MSDs. Therefore, as an alternative approach to characterizing the fluctuating diffusivity, the relative standard deviation (RSD) of the time-averaged MSD is utilized and it is shown that the RSD exhibits slow relaxation as a signature of the long-time correlation in the fluctuating diffusivity. Furthermore, it is shown that the RSD is related to a non-Gaussian parameter of the propagator. To obtain these theoretical results, we develop a two-state renewal theory as an analytical tool.

  3. Weak Ergodicity Breaking of Receptor Motion in Living Cells Stemming from Random Diffusivity

    NASA Astrophysics Data System (ADS)

    Manzo, Carlo; Torreno-Pina, Juan A.; Massignan, Pietro; Lapeyre, Gerald J.; Lewenstein, Maciej; Garcia Parajo, Maria F.

    2015-01-01

    Molecular transport in living systems regulates numerous processes underlying biological function. Although many cellular components exhibit anomalous diffusion, only recently has the subdiffusive motion been associated with nonergodic behavior. These findings have stimulated new questions for their implications in statistical mechanics and cell biology. Is nonergodicity a common strategy shared by living systems? Which physical mechanisms generate it? What are its implications for biological function? Here, we use single-particle tracking to demonstrate that the motion of dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN), a receptor with unique pathogen-recognition capabilities, reveals nonergodic subdiffusion on living-cell membranes In contrast to previous studies, this behavior is incompatible with transient immobilization, and, therefore, it cannot be interpreted according to continuous-time random-walk theory. We show that the receptor undergoes changes of diffusivity, consistent with the current view of the cell membrane as a highly dynamic and diverse environment. Simulations based on a model of an ordinary random walk in complex media quantitatively reproduce all our observations, pointing toward diffusion heterogeneity as the cause of DC-SIGN behavior. By studying different receptor mutants, we further correlate receptor motion to its molecular structure, thus establishing a strong link between nonergodicity and biological function. These results underscore the role of disorder in cell membranes and its connection with function regulation. Because of its generality, our approach offers a framework to interpret anomalous transport in other complex media where dynamic heterogeneity might play a major role, such as those found, e.g., in soft condensed matter, geology, and ecology.

  4. Transient anomalous diffusion in periodic systems: ergodicity, symmetry breaking and velocity relaxation

    PubMed Central

    Spiechowicz, Jakub; Łuczka, Jerzy; Hänggi, Peter

    2016-01-01

    We study far from equilibrium transport of a periodically driven inertial Brownian particle moving in a periodic potential. As detected for a SQUID ratchet dynamics, the mean square deviation of the particle position from its average may involve three distinct intermediate, although extended diffusive regimes: initially as superdiffusion, followed by subdiffusion and finally, normal diffusion in the asymptotic long time limit. Even though these anomalies are transient effects, their lifetime can be many, many orders of magnitude longer than the characteristic time scale of the setup and turns out to be extraordinarily sensitive to the system parameters like temperature or the potential asymmetry. In the paper we reveal mechanisms of diffusion anomalies related to ergodicity of the system, symmetry breaking of the periodic potential and ultraslow relaxation of the particle velocity towards its steady state. Similar sequences of the diffusive behaviours could be detected in various systems including, among others, colloidal particles in random potentials, glass forming liquids and granular gases. PMID:27492219

  5. Temporal correlation functions of concentration fluctuations: an anomalous case.

    PubMed

    Lubelski, Ariel; Klafter, Joseph

    2008-10-09

    We calculate, within the framework of the continuous time random walk (CTRW) model, multiparticle temporal correlation functions of concentration fluctuations (CCF) in systems that display anomalous subdiffusion. The subdiffusion stems from the nonstationary nature of the CTRW waiting times, which also lead to aging and ergodicity breaking. Due to aging, a system of diffusing particles tends to slow down as time progresses, and therefore, the temporal correlation functions strongly depend on the initial time of measurement. As a consequence, time averages of the CCF differ from ensemble averages, displaying therefore ergodicity breaking. We provide a simple example that demonstrates the difference between these two averages, a difference that might be amenable to experimental tests. We focus on the case of ensemble averaging and assume that the preparation time of the system coincides with the starting time of the measurement. Our analytical calculations are supported by computer simulations based on the CTRW model.

  6. Dynamics of comb-of-comb-network polymers in random layered flows

    NASA Astrophysics Data System (ADS)

    Katyal, Divya; Kant, Rama

    2016-12-01

    We analyze the dynamics of comb-of-comb-network polymers in the presence of external random flows. The dynamics of such structures is evaluated through relevant physical quantities, viz., average square displacement (ASD) and the velocity autocorrelation function (VACF). We focus on comparing the dynamics of the comb-of-comb network with the linear polymer. The present work displays an anomalous diffusive behavior of this flexible network in the random layered flows. The effect of the polymer topology on the dynamics is analyzed by varying the number of generations and branch lengths in these networks. In addition, we investigate the influence of external flow on the dynamics by varying flow parameters, like the flow exponent α and flow strength Wα. Our analysis highlights two anomalous power-law regimes, viz., subdiffusive (intermediate-time polymer stretching and flow-induced diffusion) and superdiffusive (long-time flow-induced diffusion). The anomalous long-time dynamics is governed by the temporal exponent ν of ASD, viz., ν =2 -α /2 . Compared to a linear polymer, the comb-of-comb network shows a shorter crossover time (from the subdiffusive to superdiffusive regime) but a reduced magnitude of ASD. Our theory displays an anomalous VACF in the random layered flows that scales as t-α /2. We show that the network with greater total mass moves faster.

  7. Anomalous transport in cellular flows: The role of initial conditions and aging

    NASA Astrophysics Data System (ADS)

    Pöschke, Patrick; Sokolov, Igor M.; Nepomnyashchy, Alexander A.; Zaks, Michael A.

    2016-09-01

    We consider the diffusion-advection problem in two simple cellular flow models (often invoked as examples of subdiffusive tracer motion) and concentrate on the intermediate time range, in which the tracer motion indeed may show subdiffusion. We perform extensive numerical simulations of the systems under different initial conditions and show that the pure intermediate-time subdiffusion regime is only evident when the particles start at the border between different cells, i.e., at the separatrix, and is less pronounced or absent for other initial conditions. The motion moreover shows quite peculiar aging properties, which are also mirrored in the behavior of the time-averaged mean squared displacement for single trajectories. This kind of behavior is due to the complex motion of tracers trapped inside the cell and is absent in classical models based on continuous-time random walks with no dynamics in the trapped state.

  8. The effects of bound state motion on macromolecular diffusion

    NASA Astrophysics Data System (ADS)

    Hough, Loren; Stefferson, Michael; Norris, Samantha; Maguire, Laura; Vernerey, Franck; Betterton, Meredith

    The diffusion of macromolecules is modified in crowded environments by both inert obstacles and interaction sites. Molecules are generally slowed in their movement inducing transient anomalous subdiffusion. Obstacles also modify the kinetics and equilibrium behavior of interaction between mobile proteins. In some biophysical contexts, bound molecules can still experience mobility, for example transcription factors sliding along DNA, membrane proteins with some entry and diffusion within lipid domains, or proteins that can enter into non-membrane bound compartments such as the nucleolus. We used lattice and continuum models to study the diffusive behavior of tracer particles which bind to obstacles and can diffuse within them. We show that binding significantly alters the motion of tracers. The type and degree of motion while bound is a key determinant of the tracer mobility. Our work has implications for protein-protein movement and interactions within living cells, including those involving intrinsically disordered proteins.

  9. Spectral Definition of the Characteristic Times for Anomalous Diffusion in a Potential

    NASA Astrophysics Data System (ADS)

    Kalmykov, Yuri P.; Coffey, William T.; Titov, Serguey V.

    Characteristic times of the noninertial fractional diffusion of a particle in a potential are defined in terms of three time constants, viz., the integral, effective, and longest relaxation times. These times are described using the eigenvalues of the corresponding Fokker-Planck operator for the normal diffusion. Knowledge of them is sufficient to accurately predict the anomalous relaxation behavior for all time scales of interest. As a particular example, we consider the subdiffusion of a planar rotor in a double-well potential.

  10. In Vivo Anomalous Diffusion and Weak Ergodicity Breaking of Lipid Granules

    NASA Astrophysics Data System (ADS)

    Jeon, Jae-Hyung; Tejedor, Vincent; Burov, Stas; Barkai, Eli; Selhuber-Unkel, Christine; Berg-Sørensen, Kirstine; Oddershede, Lene; Metzler, Ralf

    2011-01-01

    Combining extensive single particle tracking microscopy data of endogenous lipid granules in living fission yeast cells with analytical results we show evidence for anomalous diffusion and weak ergodicity breaking. Namely we demonstrate that at short times the granules perform subdiffusion according to the laws of continuous time random walk theory. The associated violation of ergodicity leads to a characteristic turnover between two scaling regimes of the time averaged mean squared displacement. At longer times the granule motion is consistent with fractional Brownian motion.

  11. Anomalous dielectric relaxation with linear reaction dynamics in space-dependent force fields.

    PubMed

    Hong, Tao; Tang, Zhengming; Zhu, Huacheng

    2016-12-28

    The anomalous dielectric relaxation of disordered reaction with linear reaction dynamics is studied via the continuous time random walk model in the presence of space-dependent electric field. Two kinds of modified reaction-subdiffusion equations are derived for different linear reaction processes by the master equation, including the instantaneous annihilation reaction and the noninstantaneous annihilation reaction. If a constant proportion of walkers is added or removed instantaneously at the end of each step, there will be a modified reaction-subdiffusion equation with a fractional order temporal derivative operating on both the standard diffusion term and a linear reaction kinetics term. If the walkers are added or removed at a constant per capita rate during the waiting time between steps, there will be a standard linear reaction kinetics term but a fractional order temporal derivative operating on an anomalous diffusion term. The dielectric polarization is analyzed based on the Legendre polynomials and the dielectric properties of both reactions can be expressed by the effective rotational diffusion function and component concentration function, which is similar to the standard reaction-diffusion process. The results show that the effective permittivity can be used to describe the dielectric properties in these reactions if the chemical reaction time is much longer than the relaxation time.

  12. Anomalous diffusion in a dynamical optical lattice

    NASA Astrophysics Data System (ADS)

    Zheng, Wei; Cooper, Nigel R.

    2018-02-01

    Motivated by experimental progress in strongly coupled atom-photon systems in optical cavities, we study theoretically the quantum dynamics of atoms coupled to a one-dimensional dynamical optical lattice. The dynamical lattice is chosen to have a period that is incommensurate with that of an underlying static lattice, leading to a dynamical version of the Aubry-André model which can cause localization of single-particle wave functions. We show that atomic wave packets in this dynamical lattice generically spread via anomalous diffusion, which can be tuned between superdiffusive and subdiffusive regimes. This anomalous diffusion arises from an interplay between Anderson localization and quantum fluctuations of the cavity field.

  13. Parsimonious Continuous Time Random Walk Models and Kurtosis for Diffusion in Magnetic Resonance of Biological Tissue

    NASA Astrophysics Data System (ADS)

    Ingo, Carson; Sui, Yi; Chen, Yufen; Parrish, Todd; Webb, Andrew; Ronen, Itamar

    2015-03-01

    In this paper, we provide a context for the modeling approaches that have been developed to describe non-Gaussian diffusion behavior, which is ubiquitous in diffusion weighted magnetic resonance imaging of water in biological tissue. Subsequently, we focus on the formalism of the continuous time random walk theory to extract properties of subdiffusion and superdiffusion through novel simplifications of the Mittag-Leffler function. For the case of time-fractional subdiffusion, we compute the kurtosis for the Mittag-Leffler function, which provides both a connection and physical context to the much-used approach of diffusional kurtosis imaging. We provide Monte Carlo simulations to illustrate the concepts of anomalous diffusion as stochastic processes of the random walk. Finally, we demonstrate the clinical utility of the Mittag-Leffler function as a model to describe tissue microstructure through estimations of subdiffusion and kurtosis with diffusion MRI measurements in the brain of a chronic ischemic stroke patient.

  14. Meaningful interpretation of subdiffusive measurements in living cells (crowded environment) by fluorescence fluctuation microscopy.

    PubMed

    Baumann, Gerd; Place, Robert F; Földes-Papp, Zeno

    2010-08-01

    In living cell or its nucleus, the motions of molecules are complicated due to the large crowding and expected heterogeneity of the intracellular environment. Randomness in cellular systems can be either spatial (anomalous) or temporal (heterogeneous). In order to separate both processes, we introduce anomalous random walks on fractals that represented crowded environments. We report the use of numerical simulation and experimental data of single-molecule detection by fluorescence fluctuation microscopy for detecting resolution limits of different mobile fractions in crowded environment of living cells. We simulate the time scale behavior of diffusion times tau(D)(tau) for one component, e.g. the fast mobile fraction, and a second component, e.g. the slow mobile fraction. The less the anomalous exponent alpha the higher the geometric crowding of the underlying structure of motion that is quantified by the ratio of the Hausdorff dimension and the walk exponent d(f)/d(w) and specific for the type of crowding generator used. The simulated diffusion time decreases for smaller values of alpha # 1 but increases for a larger time scale tau at a given value of alpha # 1. The effect of translational anomalous motion is substantially greater if alpha differs much from 1. An alpha value close to 1 contributes little to the time dependence of subdiffusive motions. Thus, quantitative determination of molecular weights from measured diffusion times and apparent diffusion coefficients, respectively, in temporal auto- and crosscorrelation analyses and from time-dependent fluorescence imaging data are difficult to interpret and biased in crowded environments of living cells and their cellular compartments; anomalous dynamics on different time scales tau must be coupled with the quantitative analysis of how experimental parameters change with predictions from simulated subdiffusive dynamics of molecular motions and mechanistic models. We first demonstrate that the crowding exponent alpha also determines the resolution of differences in diffusion times between two components in addition to photophysical parameters well-known for normal motion in dilute solution. The resolution limit between two different kinds of single molecule species is also analyzed under translational anomalous motion with broken ergodicity. We apply our theoretical predictions of diffusion times and lower limits for the time resolution of two components to fluorescence images in human prostate cancer cells transfected with GFP-Ago2 and GFP-Ago1. In order to mimic heterogeneous behavior in crowded environments of living cells, we need to introduce so-called continuous time random walks (CTRW). CTRWs were originally performed on regular lattice. This purely stochastic molecule behavior leads to subdiffusive motion with broken ergodicity in our simulations. For the first time, we are able to quantitatively differentiate between anomalous motion without broken ergodicity and anomalous motion with broken ergodicity in time-dependent fluorescence microscopy data sets of living cells. Since the experimental conditions to measure a selfsame molecule over an extended period of time, at which biology is taken place, in living cells or even in dilute solution are very restrictive, we need to perform the time average over a subpopulation of different single molecules of the same kind. For time averages over subpopulations of single molecules, the temporal auto- and crosscorrelation functions are first found. Knowing the crowding parameter alpha for the cell type and cellular compartment type, respectively, the heterogeneous parameter gamma can be obtained from the measurements in the presence of the interacting reaction partner, e.g. ligand, with the same alpha value. The product alpha x gamma = gamma is not a simple fitting parameter in the temporal auto- and two-color crosscorrelation functions because it is related to the proper physical models of anomalous (spatial) and heterogeneous (temporal) randomness in cellular systems.We have already derived an analytical solution gamma for in the special case of gamma = 3/2. In the case of two-color crosscorrelation or/and two-color fluorescence imaging (co-localization experiments), the second component is also a two-color species gr, for example a different molecular complex with an additional ligand. Here, we first show that plausible biological mechanisms from FCS/ FCCS and fluorescence imaging in living cells are highly questionable without proper quantitative physical models of subdiffusive motion and temporal randomness. At best, such quantitative FCS/ FCCS and fluorescence imaging data are difficult to interpret under crowding and heterogeneous conditions. It is challenging to translate proper physical models of anomalous (spatial) and heterogeneous (temporal) randomness in living cells and their cellular compartments like the nucleus into biological models of the cell biological process under study testable by single-molecule approaches. Otherwise, quantitative FCS/FCCS and fluorescence imaging measurements in living cells are not well described and cannot be interpreted in a meaningful way.

  15. Anomalous Diffusion of Water in Lamellar Membranes Formed by Pluronic Polymers

    NASA Astrophysics Data System (ADS)

    Zhang, Zhe; Ohl, Michael; Han, Youngkyu; Smith, Gregory; Do, Changwoo; Biology; Soft-Matter Division, Oak Ridge National Laboratory Team; Julich CenterNeutron Science Team

    Water diffusion is playing an important role in polymer systems. We calculated the water diffusion coefficient at different layers along z-direction which is perpendicular to the lamellar membrane formed by Pluronic block copolymers (L62: (EO6-PO34-EO6)) with the molecular dynamics simulation trajectories. Water molecules at bulk layers are following the normal diffusion, while that at hydration layers formed by polyethylene oxide (PEO) and hydrophobic layers formed by polypropylene oxide (PPO) are following anomalous diffusion. We find that although the subdiffusive regimes at PEO layers and PPO layers are the same, which is the fractional Brownian motion, however, the dynamics are different, i.e. diffusion at the PEO layers is much faster than that at the PPO layers, and meanwhile it exhibits a normal diffusive approximation within a short time period which is governed by the localized free self-diffusion, but becomes subdiffusive after t >8 ps, which is governed by the viscoelastic medium. The Scientific User Facilities Division, Office of Basic Energy Sciences, U.S. Department of Energy; and Zhe Zhang gratefully acknowledges financial support from Julich Center for Neutron Science.

  16. Anomalous heat conduction and anomalous diffusion in nonlinear lattices, single walled nanotubes, and billiard gas channels.

    PubMed

    Li, Baowen; Wang, Jiao; Wang, Lei; Zhang, Gang

    2005-03-01

    We study anomalous heat conduction and anomalous diffusion in low-dimensional systems ranging from nonlinear lattices, single walled carbon nanotubes, to billiard gas channels. We find that in all discussed systems, the anomalous heat conductivity can be connected with the anomalous diffusion, namely, if energy diffusion is sigma(2)(t)=2Dt(alpha) (01) implies an anomalous heat conduction with a divergent thermal conductivity (beta>0), and more interestingly, a subdiffusion (alpha<1) implies an anomalous heat conduction with a convergent thermal conductivity (beta<0), consequently, the system is a thermal insulator in the thermodynamic limit. Existing numerical data support our theoretical prediction.

  17. Fractional Dynamics of Single File Diffusion in Dusty Plasma Ring

    NASA Astrophysics Data System (ADS)

    Muniandy, S. V.; Chew, W. X.; Asgari, H.; Wong, C. S.; Lim, S. C.

    2011-11-01

    Single file diffusion (SFD) refers to the constrained motion of particles in quasi-one-dimensional channel such that the particles are unable to pass each other. Possible SFD of charged dust confined in biharmonic annular potential well with screened Coulomb interaction is investigated. Transition from normal diffusion to anomalous sub-diffusion behaviors is observed. Deviation from SFD's mean square displacement scaling behavior of 1/2-exponent may occur in strongly interacting systems. A phenomenological model based on fractional Langevin equation is proposed to account for the anomalous SFD behavior in dusty plasma ring.

  18. Crossover from anomalous to normal diffusion in porous media

    NASA Astrophysics Data System (ADS)

    Aarão Reis, F. D. A.; di Caprio, Dung

    2014-06-01

    Random walks (RW) of particles adsorbed in the internal walls of porous deposits produced by ballistic-type growth models are studied. The particles start at the external surface of the deposits and enter their pores in order to simulate an external flux of a species towards a porous solid. For short times, the walker concentration decays as a stretched exponential of the depth z, but a crossover to long-time normal diffusion is observed in most samples. The anomalous concentration profile remains at long times in very porous solids if the walker steps are restricted to nearest neighbors and is accompanied with subdiffusion features. These findings are correlated with a decay of the explored area with z. The study of RW of tracer particles left at the internal part of the solid rules out an interpretation by diffusion equations with position-dependent coefficients. A model of RW in a tube of decreasing cross section explains those results by showing long crossovers from an effective subdiffusion regime to an asymptotic normal diffusion. The crossover position and density are analytically calculated for a tube with area decreasing exponentially with z and show good agreement with numerical data. The anomalous decay of the concentration profile is interpreted as a templating effect of the tube shape on the total number of diffusing particles at each depth, while the volumetric concentration in the actually explored porous region may not have significant decay. These results may explain the anomalous diffusion of metal atoms in porous deposits observed in recent works. They also confirm the difficulty in interpreting experimental or computational data on anomalous transport reported in recent works, particularly if only the concentration profiles are measured.

  19. How molecular motors work in the crowded environment of living cells: coexistence and efficiency of normal and anomalous transport.

    PubMed

    Goychuk, Igor; Kharchenko, Vasyl O; Metzler, Ralf

    2014-01-01

    Recent experiments reveal both passive subdiffusion of various nanoparticles and anomalous active transport of such particles by molecular motors in the molecularly crowded environment of living biological cells. Passive and active microrheology reveals that the origin of this anomalous dynamics is due to the viscoelasticity of the intracellular fluid. How do molecular motors perform in such a highly viscous, dissipative environment? Can we explain the observed co-existence of the anomalous transport of relatively large particles of 100 to 500 nm in size by kinesin motors with the normal transport of smaller particles by the same molecular motors? What is the efficiency of molecular motors in the anomalous transport regime? Here we answer these seemingly conflicting questions and consistently explain experimental findings in a generalization of the well-known continuous diffusion model for molecular motors with two conformational states in which viscoelastic effects are included.

  20. How Molecular Motors Work in the Crowded Environment of Living Cells: Coexistence and Efficiency of Normal and Anomalous Transport

    PubMed Central

    Goychuk, Igor; Kharchenko, Vasyl O.; Metzler, Ralf

    2014-01-01

    Recent experiments reveal both passive subdiffusion of various nanoparticles and anomalous active transport of such particles by molecular motors in the molecularly crowded environment of living biological cells. Passive and active microrheology reveals that the origin of this anomalous dynamics is due to the viscoelasticity of the intracellular fluid. How do molecular motors perform in such a highly viscous, dissipative environment? Can we explain the observed co-existence of the anomalous transport of relatively large particles of 100 to 500 nm in size by kinesin motors with the normal transport of smaller particles by the same molecular motors? What is the efficiency of molecular motors in the anomalous transport regime? Here we answer these seemingly conflicting questions and consistently explain experimental findings in a generalization of the well-known continuous diffusion model for molecular motors with two conformational states in which viscoelastic effects are included. PMID:24626511

  1. FAST TRACK COMMUNICATION: Suppressing anomalous diffusion by cooperation

    NASA Astrophysics Data System (ADS)

    Dybiec, Bartłomiej

    2010-08-01

    Within a continuous time random walk scenario we consider a motion of a complex of particles which moves coherently. The motion of every particle is characterized by the waiting time and jump length distributions which are of the power-law type. Due to the interactions between particles it is assumed that the waiting time is adjusted to the shortest or to the longest waiting time. Analogously, the jump length is adjusted to the shortest or to the longest jump length. We show that adjustment to the shortest waiting time can suppress the subdiffusive behavior even in situations when the exponent characterizing the waiting time distribution assures subdiffusive motion of a single particle. Finally, we demonstrate that the characteristic of the motion depends on the number of particles building a complex.

  2. Reversible island nucleation and growth with anomalous diffusion

    NASA Astrophysics Data System (ADS)

    Sabbar, Ehsan H.; Amar, Jacques G.

    2017-10-01

    Motivated by recent experiments on submonolayer organic film growth with anomalous diffusion, a general rate-equation (RE) theory of submonolayer island nucleation and growth was developed (Amar and Semaan, 2016) [23], which takes into account the critical island-size i, island fractal dimension df, substrate dimension d, and diffusion exponent μ, and good agreement with simulations was found for the case of irreversible growth corresponding to a critical island-size i = 1 with d = 2 . However, since many experiments correspond to a critical island-size larger than 1, it is of interest to determine if the RE predictions also hold in the case of reversible island nucleation with anomalous diffusion. Here we present the results of simulations of submonolayer growth with i = 2 (d = 2) which were carried out for both the case of superdiffusion (μ > 1) and subdiffusion (μ < 1) as well as for both ramified islands (df ≃ 2) and point-islands (df = ∞) . In the case of superdiffusion, corresponding to 'hot' freshly deposited monomers, excellent agreement is obtained with the predictions of the generalized RE theory for the exponents χ(μ) and χ1(μ) which describe the dependence of the island and monomer densities at fixed coverage on deposition rate F. In addition, the exponents do not depend on whether or not monomers remain superdiffusive or are thermalized (e.g. undergo regular diffusion) after detaching from a dimer. However, we also find that, as was previously found in the case of irreversible growth, the exponent χ only approaches its asymptotic value logarithmically with increasing 1/F. This result has important implications for the interpretation of experiments. Good agreement with the RE theory is also found in the case of subdiffusion for point-islands. However, in the case of ramified islands with subdiffusion and i = 2 , the exponents are significantly higher than predicted due to the fact that monomer capture dominates in the nucleation regime. A modified RE theory which takes this into account is presented, and excellent agreement is found with our simulations.

  3. Continuous-time random-walk model for anomalous diffusion in expanding media

    NASA Astrophysics Data System (ADS)

    Le Vot, F.; Abad, E.; Yuste, S. B.

    2017-09-01

    Expanding media are typical in many different fields, e.g., in biology and cosmology. In general, a medium expansion (contraction) brings about dramatic changes in the behavior of diffusive transport properties such as the set of positional moments and the Green's function. Here, we focus on the characterization of such effects when the diffusion process is described by the continuous-time random-walk (CTRW) model. As is well known, when the medium is static this model yields anomalous diffusion for a proper choice of the probability density function (pdf) for the jump length and the waiting time, but the behavior may change drastically if a medium expansion is superimposed on the intrinsic random motion of the diffusing particle. For the case where the jump length and the waiting time pdfs are long-tailed, we derive a general bifractional diffusion equation which reduces to a normal diffusion equation in the appropriate limit. We then study some particular cases of interest, including Lévy flights and subdiffusive CTRWs. In the former case, we find an analytical exact solution for the Green's function (propagator). When the expansion is sufficiently fast, the contribution of the diffusive transport becomes irrelevant at long times and the propagator tends to a stationary profile in the comoving reference frame. In contrast, for a contracting medium a competition between the spreading effect of diffusion and the concentrating effect of contraction arises. In the specific case of a subdiffusive CTRW in an exponentially contracting medium, the latter effect prevails for sufficiently long times, and all the particles are eventually localized at a single point in physical space. This "big crunch" effect, totally absent in the case of normal diffusion, stems from inefficient particle spreading due to subdiffusion. We also derive a hierarchy of differential equations for the moments of the transport process described by the subdiffusive CTRW model in an expanding medium. From this hierarchy, the full time evolution of the second-order moment is obtained for some specific types of expansion. In the case of an exponential expansion, exact recurrence relations for the Laplace-transformed moments are obtained, whence the long-time behavior of moments of arbitrary order is subsequently inferred. Our analytical and numerical results for both Lévy flights and subdiffusive CTRWs confirm the intuitive expectation that the medium expansion hinders the mixing of diffusive particles occupying separate regions. In the case of Lévy flights, we quantify this effect by means of the so-called "Lévy horizon."

  4. Continuous-time random-walk model for anomalous diffusion in expanding media.

    PubMed

    Le Vot, F; Abad, E; Yuste, S B

    2017-09-01

    Expanding media are typical in many different fields, e.g., in biology and cosmology. In general, a medium expansion (contraction) brings about dramatic changes in the behavior of diffusive transport properties such as the set of positional moments and the Green's function. Here, we focus on the characterization of such effects when the diffusion process is described by the continuous-time random-walk (CTRW) model. As is well known, when the medium is static this model yields anomalous diffusion for a proper choice of the probability density function (pdf) for the jump length and the waiting time, but the behavior may change drastically if a medium expansion is superimposed on the intrinsic random motion of the diffusing particle. For the case where the jump length and the waiting time pdfs are long-tailed, we derive a general bifractional diffusion equation which reduces to a normal diffusion equation in the appropriate limit. We then study some particular cases of interest, including Lévy flights and subdiffusive CTRWs. In the former case, we find an analytical exact solution for the Green's function (propagator). When the expansion is sufficiently fast, the contribution of the diffusive transport becomes irrelevant at long times and the propagator tends to a stationary profile in the comoving reference frame. In contrast, for a contracting medium a competition between the spreading effect of diffusion and the concentrating effect of contraction arises. In the specific case of a subdiffusive CTRW in an exponentially contracting medium, the latter effect prevails for sufficiently long times, and all the particles are eventually localized at a single point in physical space. This "big crunch" effect, totally absent in the case of normal diffusion, stems from inefficient particle spreading due to subdiffusion. We also derive a hierarchy of differential equations for the moments of the transport process described by the subdiffusive CTRW model in an expanding medium. From this hierarchy, the full time evolution of the second-order moment is obtained for some specific types of expansion. In the case of an exponential expansion, exact recurrence relations for the Laplace-transformed moments are obtained, whence the long-time behavior of moments of arbitrary order is subsequently inferred. Our analytical and numerical results for both Lévy flights and subdiffusive CTRWs confirm the intuitive expectation that the medium expansion hinders the mixing of diffusive particles occupying separate regions. In the case of Lévy flights, we quantify this effect by means of the so-called "Lévy horizon."

  5. Transport in sheared stochastic magnetic fields

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Vanden Eijnden, E.; Balescu, R.

    1997-02-01

    The transport of test particles in a stochastic magnetic field with a sheared component is studied. Two stages in the particle dynamics are distinguished depending on whether the collisional effects perpendicular to the main field are negligible or not. Whenever the perpendicular collisions are unimportant, the particles show a subdiffusive behavior which is slower in the presence of shear. The particle dynamics is then inhomogeneous and non-Markovian and no diffusion coefficient may be properly defined. When the perpendicular collision frequency is small, this subdiffusive stage may be very long. In the truly asymptotic stage, however, the perpendicular collisions must bemore » accounted for and the particle motion eventually becomes diffusive. Here again, however, the shear is shown to reduce the anomalous diffusion coefficient of the system. {copyright} {ital 1997 American Institute of Physics.}« less

  6. Subdiffusion in Membrane Permeation of Small Molecules.

    PubMed

    Chipot, Christophe; Comer, Jeffrey

    2016-11-02

    Within the solubility-diffusion model of passive membrane permeation of small molecules, translocation of the permeant across the biological membrane is traditionally assumed to obey the Smoluchowski diffusion equation, which is germane for classical diffusion on an inhomogeneous free-energy and diffusivity landscape. This equation, however, cannot accommodate subdiffusive regimes, which have long been recognized in lipid bilayer dynamics, notably in the lateral diffusion of individual lipids. Through extensive biased and unbiased molecular dynamics simulations, we show that one-dimensional translocation of methanol across a pure lipid membrane remains subdiffusive on timescales approaching typical permeation times. Analysis of permeant motion within the lipid bilayer reveals that, in the absence of a net force, the mean squared displacement depends on time as t 0.7 , in stark contrast with the conventional model, which assumes a strictly linear dependence. We further show that an alternate model using a fractional-derivative generalization of the Smoluchowski equation provides a rigorous framework for describing the motion of the permeant molecule on the pico- to nanosecond timescale. The observed subdiffusive behavior appears to emerge from a crossover between small-scale rattling of the permeant around its present position in the membrane and larger-scale displacements precipitated by the formation of transient voids.

  7. Fractional cable model for signal conduction in spiny neuronal dendrites

    NASA Astrophysics Data System (ADS)

    Vitali, Silvia; Mainardi, Francesco

    2017-06-01

    The cable model is widely used in several fields of science to describe the propagation of signals. A relevant medical and biological example is the anomalous subdiffusion in spiny neuronal dendrites observed in several studies of the last decade. Anomalous subdiffusion can be modelled in several ways introducing some fractional component into the classical cable model. The Chauchy problem associated to these kind of models has been investigated by many authors, but up to our knowledge an explicit solution for the signalling problem has not yet been published. Here we propose how this solution can be derived applying the generalized convolution theorem (known as Efros theorem) for Laplace transforms. The fractional cable model considered in this paper is defined by replacing the first order time derivative with a fractional derivative of order α ∈ (0, 1) of Caputo type. The signalling problem is solved for any input function applied to the accessible end of a semi-infinite cable, which satisfies the requirements of the Efros theorem. The solutions corresponding to the simple cases of impulsive and step inputs are explicitly calculated in integral form containing Wright functions. Thanks to the variability of the parameter α, the corresponding solutions are expected to adapt to the qualitative behaviour of the membrane potential observed in experiments better than in the standard case α = 1.

  8. Constrained diffusion or immobile fraction on cell surfaces: a new interpretation.

    PubMed Central

    Feder, T J; Brust-Mascher, I; Slattery, J P; Baird, B; Webb, W W

    1996-01-01

    Protein lateral mobility in cell membranes is generally measured using fluorescence photobleaching recovery (FPR). Since the development of this technique, the data have been interpreted by assuming free Brownian diffusion of cell surface receptors in two dimensions, an interpretation that requires that a subset of the diffusing species remains immobile. The origin of this so-called immobile fraction remains a mystery. In FPR, the motions of thousands of particles are inherently averaged, inevitably masking the details of individual motions. Recently, tracking of individual cell surface receptors has identified several distinct types of motion (Gross and Webb, 1988; Ghosh and Webb, 1988, 1990, 1994; Kusumi et al. 1993; Qian et al. 1991; Slattery, 1995), thereby calling into question the classical interpretation of FPR data as free Brownian motion of a limited mobile fraction. We have measured the motion of fluorescently labeled immunoglobulin E complexed to high affinity receptors (Fc epsilon RI) on rat basophilic leukemia cells using both single particle tracking and FPR. As in previous studies, our tracking results show that individual receptors may diffuse freely, or may exhibit restricted, time-dependent (anomalous) diffusion. Accordingly, we have analyzed FPR data by a new model to take this varied motion into account, and we show that the immobile fraction may be due to particles moving with the anomalous subdiffusion associated with restricted lateral mobility. Anomalous subdiffusion denotes random molecular motion in which the mean square displacements grow as a power law in time with a fractional positive exponent less than one. These findings call for a new model of cell membrane structure. PMID:8744314

  9. Experimental tests of truncated diffusion in fault damage zones

    NASA Astrophysics Data System (ADS)

    Suzuki, Anna; Hashida, Toshiyuki; Li, Kewen; Horne, Roland N.

    2016-11-01

    Fault zones affect the flow paths of fluids in groundwater aquifers and geological reservoirs. Fault-related fracture damage decreases to background levels with increasing distance from the fault core according to a power law. This study investigated mass transport in such a fault-related structure using nonlocal models. A column flow experiment is conducted to create a permeability distribution that varies with distance from a main conduit. The experimental tracer response curve is preasymptotic and implies subdiffusive transport, which is slower than the normal Fickian diffusion. If the surrounding area is a finite domain, an upper truncated behavior in tracer response (i.e., exponential decline at late times) is observed. The tempered anomalous diffusion (TAD) model captures the transition from subdiffusive to Fickian transport, which is characterized by a smooth transition from power-law to an exponential decline in the late-time breakthrough curves.

  10. Anomalous transport regimes and asymptotic concentration distributions in the presence of advection and diffusion on a comb structure

    NASA Astrophysics Data System (ADS)

    Dvoretskaya, Olga A.; Kondratenko, Peter S.

    2009-04-01

    We study the transport of impurity particles on a comb structure in the presence of advection. The main body concentration and asymptotic concentration distributions are obtained. Seven different transport regimes occur on the comb structure with finite teeth: classical diffusion, advection, quasidiffusion, subdiffusion, slow classical diffusion, and two kinds of slow advection. Quasidiffusion deserves special attention. It is characterized by a linear growth of the mean-square displacement. However, quasidiffusion is an anomalous transport regime. We established that a change in transport regimes in time leads to a change in regimes in space. Concentration tails have a cascade structure, namely, consisting of several parts.

  11. Computational analysis of the roles of biochemical reactions in anomalous diffusion dynamics

    NASA Astrophysics Data System (ADS)

    Naruemon, Rueangkham; Charin, Modchang

    2016-04-01

    Most biochemical processes in cells are usually modeled by reaction-diffusion (RD) equations. In these RD models, the diffusive process is assumed to be Gaussian. However, a growing number of studies have noted that intracellular diffusion is anomalous at some or all times, which may result from a crowded environment and chemical kinetics. This work aims to computationally study the effects of chemical reactions on the diffusive dynamics of RD systems by using both stochastic and deterministic algorithms. Numerical method to estimate the mean-square displacement (MSD) from a deterministic algorithm is also investigated. Our computational results show that anomalous diffusion can be solely due to chemical reactions. The chemical reactions alone can cause anomalous sub-diffusion in the RD system at some or all times. The time-dependent anomalous diffusion exponent is found to depend on many parameters, including chemical reaction rates, reaction orders, and chemical concentrations. Project supported by the Thailand Research Fund and Mahidol University (Grant No. TRG5880157), the Thailand Center of Excellence in Physics (ThEP), CHE, Thailand, and the Development Promotion of Science and Technology.

  12. Single Molecule Fluorescence Measurements of Complex Systems

    NASA Astrophysics Data System (ADS)

    Sadegh, Sanaz

    Single molecule methods are powerful tools for investigating the properties of complex systems that are generally concealed by ensemble measurements. Here we use single molecule fluorescent measurements to study two different complex systems: 1/ƒ noise in quantum dots and diffusion of the membrane proteins in live cells. The power spectrum of quantum dot (QD) fluorescence exhibits 1/ƒ beta noise, related to the intermittency of these nanosystems. As in other systems exhibiting 1/ƒ noise, this power spectrum is not integrable at low frequencies, which appears to imply infinite total power. We report measurements of individual QDs that address this long-standing paradox. We find that the level of 1/ƒbeta noise for QDs decays with the observation time. We show that the traditional description of the power spectrum with a single exponent is incomplete and three additional critical exponents characterize the dependence on experimental time. A broad range of membrane proteins display anomalous diffusion on the cell surface. Different methods provide evidence for obstructed subdiffusion and diffusion on a fractal space, but the underlying structure inducing anomalous diffusion has never been visualized due to experimental challenges. We addressed this problem by imaging the cortical actin at high resolution while simultaneously tracking individual membrane proteins in live mammalian cells. Our data show that actin introduces barriers leading to compartmentalization of the plasma membrane and that membrane proteins are transiently confined within actin fences. Furthermore, superresolution imaging shows that the cortical actin is organized into a self-similar fractal.

  13. Anomalous diffusion of Ibuprofen in cyclodextrin nanosponge hydrogels: an HRMAS NMR study.

    PubMed

    Ferro, Monica; Castiglione, Franca; Punta, Carlo; Melone, Lucio; Panzeri, Walter; Rossi, Barbara; Trotta, Francesco; Mele, Andrea

    2014-01-01

    Ibuprofen sodium salt (IP) was encapsulated in cyclodextrin nanosponges (CDNS) obtained by cross-linking of β-cyclodextrin with ethylenediaminetetraacetic acid dianhydride (EDTAn) in two different preparations: CDNSEDTA 1:4 and 1:8, where the 1:n notation indicates the CD to EDTAn molar ratio. The entrapment of IP was achieved by swelling the two polymers with a 0.27 M solution of IP in D2O, leading to colourless, homogeneous hydrogels loaded with IP. The molecular environment and the transport properties of IP in the hydrogels were studied by high resolution magic angle spinning (HRMAS) NMR spectroscopy. The mean square displacement (MSD) of IP in the gels was obtained by a pulsed field gradient spin echo (PGSE) NMR pulse sequence at different observation times t d. The MSD is proportional to the observation time elevated to a scaling factor α. The α values define the normal Gaussian random motion (α = 1), or the anomalous diffusion (α < 1, subdiffusion, α > 1 superdiffusion). The experimental data here reported point out that IP undergoes subdiffusive regime in CDNSEDTA 1:4, while a slightly superdiffusive behaviour is observed in CDNSEDTA 1:8. The transition between the two dynamic regimes is triggered by the polymer structure. CDNSEDTA 1:4 is characterized by a nanoporous structure able to induce confinement effects on IP, thus causing subdiffusive random motion. CDNSEDTA 1:8 is characterized not only by nanopores, but also by dangling EDTA groups ending with ionized COO(-) groups. The negative potential provided by such groups to the polymer backbone is responsible for the acceleration effects on the IP anion thus leading to the superdiffusive behaviour observed. These results point out that HRMAS NMR spectroscopy is a powerful direct method for the assessment of the transport properties of a drug encapsulated in polymeric scaffolds. The diffusion properties of IP in CDNS can be modulated by suitable polymer synthesis; this finding opens the possibility to design suitable systems for drug delivery with predictable and desired drug release properties.

  14. Communication: Probing anomalous diffusion in frequency space

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stachura, Sławomir; Synchrotron Soleil, L’Orme de Merisiers, 91192 Gif-sur-Yvette; Kneller, Gerald R., E-mail: gerald.kneller@cnrs-orleans.fr

    Anomalous diffusion processes are usually detected by analyzing the time-dependent mean square displacement of the diffusing particles. The latter evolves asymptotically as W(t) ∼ 2D{sub α}t{sup α}, where D{sub α} is the fractional diffusion constant and 0 < α < 2. In this article we show that both D{sub α} and α can also be extracted from the low-frequency Fourier spectrum of the corresponding velocity autocorrelation function. This offers a simple method for the interpretation of quasielastic neutron scattering spectra from complex (bio)molecular systems, in which subdiffusive transport is frequently encountered. The approach is illustrated and validated by analyzing molecularmore » dynamics simulations of molecular diffusion in a lipid POPC bilayer.« less

  15. Two-photon time-lapse microscopy of BODIPY-cholesterol reveals anomalous sterol diffusion in chinese hamster ovary cells

    PubMed Central

    2012-01-01

    Background Cholesterol is an important membrane component, but our knowledge about its transport in cells is sparse. Previous imaging studies using dehydroergosterol (DHE), an intrinsically fluorescent sterol from yeast, have established that vesicular and non-vesicular transport modes contribute to sterol trafficking from the plasma membrane. Significant photobleaching, however, limits the possibilities for in-depth analysis of sterol dynamics using DHE. Co-trafficking studies with DHE and the recently introduced fluorescent cholesterol analog BODIPY-cholesterol (BChol) suggested that the latter probe has utility for prolonged live-cell imaging of sterol transport. Results We found that BChol is very photostable under two-photon (2P)-excitation allowing the acquisition of several hundred frames without significant photobleaching. Therefore, long-term tracking and diffusion measurements are possible. Two-photon temporal image correlation spectroscopy (2P-TICS) provided evidence for spatially heterogeneous diffusion constants of BChol varying over two orders of magnitude from the cell interior towards the plasma membrane, where D ~ 1.3 μm2/s. Number and brightness (N&B) analysis together with stochastic simulations suggest that transient partitioning of BChol into convoluted membranes slows local sterol diffusion. We observed sterol endocytosis as well as fusion and fission of sterol-containing endocytic vesicles. The mobility of endocytic vesicles, as studied by particle tracking, is well described by a model for anomalous subdiffusion on short time scales with an anomalous exponent α ~ 0.63 and an anomalous diffusion constant of Dα = 1.95 x 10-3 μm2/sα. On a longer time scale (t > ~5 s), a transition to superdiffusion consistent with slow directed transport with an average velocity of v ~ 6 x 10-3 μm/s was observed. We present an analytical model that bridges the two regimes and fit this model to vesicle trajectories from control cells and cells with disrupted microtubule or actin filaments. Both treatments reduced the anomalous diffusion constant and the velocity by ~40-50%. Conclusions The mobility of sterol-containing vesicles on the short time scale could reflect dynamic rearrangements of the cytoskeleton, while directed transport of sterol vesicles occurs likely along both, microtubules and actin filaments. Spatially varying anomalous diffusion could contribute to fine-tuning and local regulation of intracellular sterol transport. PMID:23078907

  16. Non-equilibrium forces drive the anomalous diffusion of telomeres in the nucleus of mammalian cells

    NASA Astrophysics Data System (ADS)

    Stadler, Lorenz; Weiss, Matthias

    2017-11-01

    Telomeres are vital nucleotide sequences at both ends of each chromosome, and their motion reports on the local dynamics of decondensed chromatin in the nucleus of interphase cells. Here, we show that the previously reported subdiffusive motion of telomeres is driven by non-equilibrium cytoskeletal forces. In particular, breaking down microtubules leads to a significantly reduced generalized diffusion coefficient of telomeres. This translates into a markedly reduced effective temperature in the stochastic forces that govern the telomeres’ random walk. Moreover, telomere motion in cells that lack microtubules is well described by the monomer dynamics of a Rouse polymer that is embeddded in a viscoelastic medium. In contrast, active cytoskeletal forces in untreated cells override the environment’s elastic contributions, resulting in the well-known scaling for conventional Rouse dynamics in viscous media. Our data highlight that even subdiffusive motion in cells in most cases may not be a simple thermal transport process but rather is driven by non-equilibrium events.

  17. Fractional Brownian motion with a reflecting wall

    NASA Astrophysics Data System (ADS)

    Wada, Alexander H. O.; Vojta, Thomas

    2018-02-01

    Fractional Brownian motion, a stochastic process with long-time correlations between its increments, is a prototypical model for anomalous diffusion. We analyze fractional Brownian motion in the presence of a reflecting wall by means of Monte Carlo simulations. Whereas the mean-square displacement of the particle shows the expected anomalous diffusion behavior ˜tα , the interplay between the geometric confinement and the long-time memory leads to a highly non-Gaussian probability density function with a power-law singularity at the barrier. In the superdiffusive case α >1 , the particles accumulate at the barrier leading to a divergence of the probability density. For subdiffusion α <1 , in contrast, the probability density is depleted close to the barrier. We discuss implications of these findings, in particular, for applications that are dominated by rare events.

  18. Anomalous diffusion of Ibuprofen in cyclodextrin nanosponge hydrogels: an HRMAS NMR study

    PubMed Central

    Ferro, Monica; Punta, Carlo; Melone, Lucio; Panzeri, Walter; Rossi, Barbara; Trotta, Francesco

    2014-01-01

    Summary Ibuprofen sodium salt (IP) was encapsulated in cyclodextrin nanosponges (CDNS) obtained by cross-linking of β-cyclodextrin with ethylenediaminetetraacetic acid dianhydride (EDTAn) in two different preparations: CDNSEDTA 1:4 and 1:8, where the 1:n notation indicates the CD to EDTAn molar ratio. The entrapment of IP was achieved by swelling the two polymers with a 0.27 M solution of IP in D2O, leading to colourless, homogeneous hydrogels loaded with IP. The molecular environment and the transport properties of IP in the hydrogels were studied by high resolution magic angle spinning (HRMAS) NMR spectroscopy. The mean square displacement (MSD) of IP in the gels was obtained by a pulsed field gradient spin echo (PGSE) NMR pulse sequence at different observation times t d. The MSD is proportional to the observation time elevated to a scaling factor α. The α values define the normal Gaussian random motion (α = 1), or the anomalous diffusion (α < 1, subdiffusion, α > 1 superdiffusion). The experimental data here reported point out that IP undergoes subdiffusive regime in CDNSEDTA 1:4, while a slightly superdiffusive behaviour is observed in CDNSEDTA 1:8. The transition between the two dynamic regimes is triggered by the polymer structure. CDNSEDTA 1:4 is characterized by a nanoporous structure able to induce confinement effects on IP, thus causing subdiffusive random motion. CDNSEDTA 1:8 is characterized not only by nanopores, but also by dangling EDTA groups ending with ionized COO− groups. The negative potential provided by such groups to the polymer backbone is responsible for the acceleration effects on the IP anion thus leading to the superdiffusive behaviour observed. These results point out that HRMAS NMR spectroscopy is a powerful direct method for the assessment of the transport properties of a drug encapsulated in polymeric scaffolds. The diffusion properties of IP in CDNS can be modulated by suitable polymer synthesis; this finding opens the possibility to design suitable systems for drug delivery with predictable and desired drug release properties. PMID:25550735

  19. Fractional Brownian motion with a reflecting wall.

    PubMed

    Wada, Alexander H O; Vojta, Thomas

    2018-02-01

    Fractional Brownian motion, a stochastic process with long-time correlations between its increments, is a prototypical model for anomalous diffusion. We analyze fractional Brownian motion in the presence of a reflecting wall by means of Monte Carlo simulations. Whereas the mean-square displacement of the particle shows the expected anomalous diffusion behavior 〈x^{2}〉∼t^{α}, the interplay between the geometric confinement and the long-time memory leads to a highly non-Gaussian probability density function with a power-law singularity at the barrier. In the superdiffusive case α>1, the particles accumulate at the barrier leading to a divergence of the probability density. For subdiffusion α<1, in contrast, the probability density is depleted close to the barrier. We discuss implications of these findings, in particular, for applications that are dominated by rare events.

  20. Anomalous diffusion for bed load transport with a physically-based model

    NASA Astrophysics Data System (ADS)

    Fan, N.; Singh, A.; Foufoula-Georgiou, E.; Wu, B.

    2013-12-01

    Diffusion of bed load particles shows both normal and anomalous behavior for different spatial-temporal scales. Understanding and quantifying these different types of diffusion is important not only for the development of theoretical models of particle transport but also for practical purposes, e.g., river management. Here we extend a recently proposed physically-based model of particle transport by Fan et al. [2013] to further develop an Episodic Langevin equation (ELE) for individual particle motion which reproduces the episodic movement (start and stop) of sediment particles. Using the proposed ELE we simulate particle movements for a large number of uniform size particles, incorporating different probability distribution functions (PDFs) of particle waiting time. For exponential PDFs of waiting times, particles reveal ballistic motion in short time scales and turn to normal diffusion at long time scales. The PDF of simulated particle travel distances also shows a change in its shape from exponential to Gamma to Gaussian with a change in timescale implying different diffusion scaling regimes. For power-law PDF (with power - μ) of waiting times, the asymptotic behavior of particles at long time scales reveals both super-diffusion and sub-diffusion, however, only very heavy tailed waiting times (i.e. 1.0 < μ < 1.5) could result in sub-diffusion. We suggest that the contrast between our results and previous studies (for e.g., studies based on fractional advection-diffusion models of thin/heavy tailed particle hops and waiting times) results could be due the assumption in those studies that the hops are achieved instantaneously, but in reality, particles achieve their hops within finite times (as we simulate here) instead of instantaneously, even if the hop times are much shorter than waiting times. In summary, this study stresses on the need to rethink the alternative models to the previous models, such as, fractional advection-diffusion equations, for studying the anomalous diffusion of bed load particles. The implications of these results for modeling sediment transport are discussed.

  1. Apparent Anomalous Diffusion in the Cytoplasm of Human Cells: The Effect of Probes' Polydispersity.

    PubMed

    Kalwarczyk, Tomasz; Kwapiszewska, Karina; Szczepanski, Krzysztof; Sozanski, Krzysztof; Szymanski, Jedrzej; Michalska, Bernadeta; Patalas-Krawczyk, Paulina; Duszynski, Jerzy; Holyst, Robert

    2017-10-26

    This work, based on in vivo and in vitro measurements, as well as in silico simulations, provides a consistent analysis of diffusion of polydisperse nanoparticles in the cytoplasm of living cells. Using the example of fluorescence correlation spectroscopy (FCS), we show the effect of polydispersity of probes on the experimental results. Although individual probes undergo normal diffusion, in the ensemble of probes, an effective broadening of the distribution of diffusion times occurs-similar to anomalous diffusion. We introduced fluorescently labeled dextrans into the cytoplasm of HeLa cells and found that cytoplasmic hydrodynamic drag, exponentially dependent on probe size, extraordinarily broadens the distribution of diffusion times across the focal volume. As a result, the in vivo FCS data were effectively fitted with the anomalous subdiffusion model while for a monodisperse probe the normal diffusion model was most suitable. Diffusion time obtained from the anomalous diffusion model corresponds to a probe whose size is determined by the weight-average molecular weight of the polymer. The apparent anomaly exponent decreases with increasing polydispersity of the probes. Our results and methodology can be applied in intracellular studies of the mobility of nanoparticles, polymers, or oligomerizing proteins.

  2. Characterizing acid diffusion lengths in chemically amplified resists from measurements of deprotection kinetics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Patil, Abhijit A.; Pandey, Yogendra Narayan; Doxastakis, Manolis

    2014-10-01

    The acid-catalyzed deprotection of glassy poly(4-hydroxystyrene-co-tertbutyl acrylate) films was studied with infrared absorbance spectroscopy and stochastic simulations. Experimental data were interpreted with a simple description of subdiffusive acid transport coupled to second-order acid loss. This model predicts key attributes of observed deprotection rates, such as fast reaction at short times, slow reaction at long times, and a nonlinear dependence on acid loading. Fickian diffusion is approached by increasing the post-exposure bake temperature or adding plasticizing agents to the polymer resin. These findings demonstrate that acid mobility and overall deprotection kinetics are coupled to glassy matrix dynamics. To complement the analysismore » of bulk kinetics, acid diffusion lengths were calculated from the anomalous transport model and compared with nanopattern line widths. The consistent scaling between experiments and simulations suggests that the anomalous diffusion model could be further developed into a predictive lithography tool.« less

  3. Role of Heterogeneous Macromolecular Crowding and Geometrical Irregularity at Central Excitatory Synapses in Shaping Synaptic Transmission

    PubMed Central

    Gupta, Rahul; Reneaux, Melissa; Karmeshu

    2016-01-01

    Besides the geometrical tortousity due to the extrasynaptic structures, macromolecular crowding and geometrical irregularities constituting the cleft composition at central excitatory synapses has a major and direct role in retarding the glutamate diffusion within the cleft space. However, the cleft composition may not only coarsely reduce the overall diffusivity of the glutamate but may also lead to substantial spatial variation in the diffusivity across the cleft space. Decrease in the overall diffusivity of the glutamate may have straightforward consequences to the glutamate transients in the cleft. However, how spatial variation in the diffusivity may further affect glutamate transients is an intriguing aspect. Therefore, to understand the role of cleft heterogeneity, the present study adopts a novel approach of glutamate diffusion which considers a gamma statistical distribution of the diffusion coefficient of glutamate (Dglut) across the cleft space, such that its moments discernibly capture the dual impacts of the cleft composition, and further applies the framework of superstatistics. The findings reveal a power law behavior in the glutamate transients, akin to the long-range anomalous subdiffusion, which leads to slower decay profile of cleft glutamate at higher intensity of cleft heterogeneity. Moreover, increase in the cleft heterogeneity is seen to eventually cause slower-rising excitatory postsynaptic currents with higher amplitudes, lesser noise, and prolonged duration of charge transfer across the postsynaptic membrane. Further, with regard to the conventional standard diffusion approach, the study suggests that the effective Dglut essentially derives from the median of the Dglut distribution and does not necessarily need to be the mean Dglut. Together, the findings indicate a strong implication of cleft heterogeneity to the metabolically cost-effective tuning of synaptic response during the phenomenon of plasticity at individual synapses and also provide an additional factor of variability in transmission across identical synapses. PMID:27907112

  4. First passage times and asymmetry of DNA translocation

    NASA Astrophysics Data System (ADS)

    Lua, Rhonald C.; Grosberg, Alexander Y.

    2005-12-01

    Motivated by experiments in which single-stranded DNA with a short hairpin loop at one end undergoes unforced diffusion through a narrow pore, we study the first passage times for a particle, executing one-dimensional Brownian motion in an asymmetric sawtooth potential, to exit one of the boundaries. We consider the first passage times for the case of classical diffusion, characterized by a mean-square displacement of the form ⟨(Δx)2⟩˜t , and for the case of anomalous diffusion or subdiffusion, characterized by a mean-square displacement of the form ⟨(Δx)2⟩˜tγ with 0<γ<1 . In the context of classical diffusion, we obtain an expression for the mean first passage time and show that this quantity changes when the direction of the sawtooth is reversed or, equivalently, when the reflecting and absorbing boundaries are exchanged. We discuss at which numbers of “teeth” N (or number of DNA nucleotides) and at which heights of the sawtooth potential this difference becomes significant. For large N , it is well known that the mean first passage time scales as N2 . In the context of subdiffusion, the mean first passage time does not exist. Therefore, we obtain instead the distribution of first passage times in the limit of long times. We show that the prefactor in the power relation for this distribution is simply the expression for the mean first passage time in classical diffusion. We also describe a hypothetical experiment to calculate the average of the first passage times for a fraction of passage events that each end within some time t* . We show that this average first passage time scales as N2/γ in subdiffusion.

  5. Modelling nematode movement using time-fractional dynamics.

    PubMed

    Hapca, Simona; Crawford, John W; MacMillan, Keith; Wilson, Mike J; Young, Iain M

    2007-09-07

    We use a correlated random walk model in two dimensions to simulate the movement of the slug parasitic nematode Phasmarhabditis hermaphrodita in homogeneous environments. The model incorporates the observed statistical distributions of turning angle and speed derived from time-lapse studies of individual nematode trails. We identify strong temporal correlations between the turning angles and speed that preclude the case of a simple random walk in which successive steps are independent. These correlated random walks are appropriately modelled using an anomalous diffusion model, more precisely using a fractional sub-diffusion model for which the associated stochastic process is characterised by strong memory effects in the probability density function.

  6. Improved estimation of anomalous diffusion exponents in single-particle tracking experiments

    NASA Astrophysics Data System (ADS)

    Kepten, Eldad; Bronshtein, Irena; Garini, Yuval

    2013-05-01

    The mean square displacement is a central tool in the analysis of single-particle tracking experiments, shedding light on various biophysical phenomena. Frequently, parameters are extracted by performing time averages on single-particle trajectories followed by ensemble averaging. This procedure, however, suffers from two systematic errors when applied to particles that perform anomalous diffusion. The first is significant at short-time lags and is induced by measurement errors. The second arises from the natural heterogeneity in biophysical systems. We show how to estimate and correct these two errors and improve the estimation of the anomalous parameters for the whole particle distribution. As a consequence, we manage to characterize ensembles of heterogeneous particles even for rather short and noisy measurements where regular time-averaged mean square displacement analysis fails. We apply this method to both simulations and in vivo measurements of telomere diffusion in 3T3 mouse embryonic fibroblast cells. The motion of telomeres is found to be subdiffusive with an average exponent constant in time. Individual telomere exponents are normally distributed around the average exponent. The proposed methodology has the potential to improve experimental accuracy while maintaining lower experimental costs and complexity.

  7. Effects of soft interactions and bound mobility on diffusion in crowded environments: a model of sticky and slippery obstacles

    NASA Astrophysics Data System (ADS)

    Stefferson, Michael W.; Norris, Samantha L.; Vernerey, Franck J.; Betterton, Meredith D.; E Hough, Loren

    2017-08-01

    Crowded environments modify the diffusion of macromolecules, generally slowing their movement and inducing transient anomalous subdiffusion. The presence of obstacles also modifies the kinetics and equilibrium behavior of tracers. While previous theoretical studies of particle diffusion have typically assumed either impenetrable obstacles or binding interactions that immobilize the particle, in many cellular contexts bound particles remain mobile. Examples include membrane proteins or lipids with some entry and diffusion within lipid domains and proteins that can enter into membraneless organelles or compartments such as the nucleolus. Using a lattice model, we studied the diffusive movement of tracer particles which bind to soft obstacles, allowing tracers and obstacles to occupy the same lattice site. For sticky obstacles, bound tracer particles are immobile, while for slippery obstacles, bound tracers can hop without penalty to adjacent obstacles. In both models, binding significantly alters tracer motion. The type and degree of motion while bound is a key determinant of the tracer mobility: slippery obstacles can allow nearly unhindered diffusion, even at high obstacle filling fraction. To mimic compartmentalization in a cell, we examined how obstacle size and a range of bound diffusion coefficients affect tracer dynamics. The behavior of the model is similar in two and three spatial dimensions. Our work has implications for protein movement and interactions within cells.

  8. Anomalous Diffusion of Particles Dispersed in Xanthan Solutions Subjected to Shear Flow

    NASA Astrophysics Data System (ADS)

    Takikawa, Yoshinori; Yasuta, Muneharu; Fujii, Shuji; Orihara, Hiroshi; Tanaka, Yoshimi; Nishinari, Katsuyoshi

    2018-05-01

    Xanthan gum exhibits viscoelastic and shear-thinning properties. We investigate the Brownian motion of particles dispersed in xanthan gum solutions that are subjected to simple shear flow. The mean square displacements (MSDs) are obtained in both the flow and vorticity directions. In the absence of shear flow, subdiffusion is observed, MSD ∝ tα with α < 1, where t is time. In the presence of shear flow, however, the exponent α becomes larger together with the MSD itself in both the flow and vorticity directions. We show that the diffusion is enhanced by Taylor dispersion in the flow direction, whereas in the vorticity direction it is enhanced by nonthermal self-diffusion.

  9. Reactions and Transport: Diffusion, Inertia, and Subdiffusion

    NASA Astrophysics Data System (ADS)

    Méndez, Vicenç; Fedotov, Sergei; Horsthemke, Werner

    Particles, such as molecules, atoms, or ions, and individuals, such as cells or animals, move in space driven by various forces or cues. In particular, particles or individuals can move randomly, undergo velocity jump processes or spatial jump processes [333]. The steps of the random walk can be independent or correlated, unbiased or biased. The probability density function (PDF) for the jump length can decay rapidly or exhibit a heavy tail. Similarly, the PDF for the waiting time between successive jumps can decay rapidly or exhibit a heavy tail. We will discuss these various possibilities in detail in Chap. 3. Below we provide an introduction to three transport processes: standard diffusion, transport with inertia, and anomalous diffusion.

  10. Transport behaviors of locally fractional coupled Brownian motors with fluctuating interactions

    NASA Astrophysics Data System (ADS)

    Wang, Huiqi; Ni, Feixiang; Lin, Lifeng; Lv, Wangyong; Zhu, Hongqiang

    2018-09-01

    In some complex viscoelastic mediums, it is ubiquitous that absorbing and desorbing surrounding Brownian particles randomly occur in coupled systems. The conventional method is to model a variable-mass system driven by both multiplicative and additive noises. In this paper, an improved mathematical model is created based on generalized Langevin equations (GLE) to characterize the random interaction with locally fluctuating number of coupled particles in the elastically coupled factional Brownian motors (FBM). By the numerical simulations, the effect of fluctuating interactions on collective transport behaviors is investigated, and some abnormal phenomena, such as cooperative behaviors, stochastic resonance (SR) and anomalous transport, are observed in the regime of sub-diffusion.

  11. Tiny Hiccups To Titanic Explosions: Tackling Transients in Anomalous X-ray Pulsars

    NASA Astrophysics Data System (ADS)

    Kaspi, Victoria

    2006-09-01

    Recently discovered transient events in Anomalous X-ray Pulsars (AXPs) may be a Rosetta Stone for understanding the persistent emission from magnetars. They also may hold the key to quantifying the number of magnetars in the Galaxy. Here we request Chandra TOO time to observe any AXP following a rare transient event, including a major outburst or a long-duration flare. Specifically, the requested observations will determine the pulsed fraction and spectral evolution of a transient AXP event as the source relaxes back to quiescence, in order to quantitatively test the "twisted magnetosphere" model for magnetars, and establish the basic phenomenology of transient AXP events.

  12. TINY HICCUPS TO TITANIC EXPLOSIONS: Tackling Transients in Anomalous X-ray Pulsars

    NASA Astrophysics Data System (ADS)

    Kaspi, Victoria

    2007-09-01

    Recently discovered transient events in Anomalous X-ray Pulsars (AXPs) may be a Rosetta Stone for understanding the persistent emission from magnetars. They also may hold the key to quantifying the number of magnetars in the Galaxy. Here we request Chandra TOO time to observe any AXP following a rare transient event, including a major outburst or a long-duration flare. Specifically, the requested observations will determine the pulsed fraction and spectral evolution of a transient AXP event as the source relaxes back to quiescence, in order to quantitatively test the "twisted magnetosphere" model for magnetars, and establish the basic phenomenology of transient AXP events.

  13. Anomalous Extracellular Diffusion in Rat Cerebellum

    PubMed Central

    Xiao, Fanrong; Hrabe, Jan; Hrabetova, Sabina

    2015-01-01

    Extracellular space (ECS) is a major channel transporting biologically active molecules and drugs in the brain. Diffusion-mediated transport of these substances is hindered by the ECS structure but the microscopic basis of this hindrance is not fully understood. One hypothesis proposes that the hindrance originates in large part from the presence of dead-space (DS) microdomains that can transiently retain diffusing molecules. Because previous theoretical and modeling work reported an initial period of anomalous diffusion in similar environments, we expected that brain regions densely populated by DS microdomains would exhibit anomalous extracellular diffusion. Specifically, we targeted granular layers (GL) of rat and turtle cerebella that are populated with large and geometrically complex glomeruli. The integrative optical imaging (IOI) method was employed to evaluate diffusion of fluorophore-labeled dextran (MW 3000) in GL, and the IOI data analysis was adapted to quantify the anomalous diffusion exponent dw from the IOI records. Diffusion was significantly anomalous in rat GL, where dw reached 4.8. In the geometrically simpler turtle GL, dw was elevated but not robustly anomalous (dw = 2.6). The experimental work was complemented by numerical Monte Carlo simulations of anomalous ECS diffusion in several three-dimensional tissue models containing glomeruli-like structures. It demonstrated that both the duration of transiently anomalous diffusion and the anomalous exponent depend on the size of model glomeruli and the degree of their wrapping. In conclusion, we have found anomalous extracellular diffusion in the GL of rat cerebellum. This finding lends support to the DS microdomain hypothesis. Transiently anomalous diffusion also has a profound effect on the spatiotemporal distribution of molecules released into the ECS, especially at diffusion distances on the order of a few cell diameters, speeding up short-range diffusion-mediated signals in less permeable structures. PMID:25954895

  14. The Shape of Protein Crowders is a Major Determinant of Protein Diffusion

    PubMed Central

    Balbo, Jessica; Mereghetti, Paolo; Herten, Dirk-Peter; Wade, Rebecca C.

    2013-01-01

    As a model for understanding how molecular crowding influences diffusion and transport of proteins in cellular environments, we combined experimental and theoretical approaches to study the diffusion of proteins in highly concentrated protein solutions. Bovine serum albumin and γ-Globulin were chosen as molecular crowders and as tracers. These two proteins are representatives of the main types of plasma protein and have different shapes and sizes. Solutions consisting of one or both proteins were studied. The self-diffusion coefficients of the fluorescently labeled tracer proteins were measured by means of fluorescence correlation spectroscopy at a total protein concentration of up to 400 g/L. γ-Globulin is found to have a stronger influence as a crowder on the tracer self-diffusion coefficient than Bovine serum albumin. Brownian dynamics simulations show that the excluded volume and the shape of the crowding protein have a significantly stronger influence on translational and rotational diffusion coefficients, as well as transient oligomerization, than hydrodynamic or direct interactions. Anomalous subdiffusion, which is not observed at the experimental fluorescence correlation spectroscopy timescales (>100 μs), appears only at very short timescales (<1 μs) in the simulations due to steric effects of the proteins. We envision that the combined experimental and computational approach employed here can be developed to unravel the different biophysical contributions to protein motion and interaction in cellular environments by systematically varying protein properties such as molecular weight, size, shape, and electrostatic interactions. PMID:23561534

  15. Anomalous transport in turbulent plasmas and continuous time random walks

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Balescu, R.

    1995-05-01

    The possibility of a model of anomalous transport problems in a turbulent plasma by a purely stochastic process is investigated. The theory of continuous time random walks (CTRW`s) is briefly reviewed. It is shown that a particular class, called the standard long tail CTRW`s is of special interest for the description of subdiffusive transport. Its evolution is described by a non-Markovian diffusion equation that is constructed in such a way as to yield exact values for all the moments of the density profile. The concept of a CTRW model is compared to an exact solution of a simple test problem:more » transport of charged particles in a fluctuating magnetic field in the limit of infinite perpendicular correlation length. Although the well-known behavior of the mean square displacement proportional to {ital t}{sup 1/2} is easily recovered, the exact density profile cannot be modeled by a CTRW. However, the quasilinear approximation of the kinetic equation has the form of a non-Markovian diffusion equation and can thus be generated by a CTRW.« less

  16. Anomalous diffusion of water molecules at grain boundaries in ice Ih.

    PubMed

    Moreira, Pedro Augusto Franco Pinheiro; Veiga, Roberto Gomes de Aguiar; Ribeiro, Ingrid de Almeida; Freitas, Rodrigo; Helfferich, Julian; de Koning, Maurice

    2018-05-23

    Using ab initio and classical molecular dynamics simulations, we study pre-melting phenomena in pristine coincident-site-lattice grain boundaries (GBs) in proton-disordered hexagonal ice Ih at temperatures just below the melting point Tm. Concerning pre-melt-layer thicknesses, the results are consistent with the available experimental estimates for low-disorder impurity-free GBs. With regard to molecular mobility, the simulations provide a key new insight: the translational motion of the water molecules is found to be subdiffusive for time scales from ∼10 ns up to at least 0.1 μs. Moreover, the fact that the anomalous diffusion occurs even at temperatures just below Tm where the bulk supercooled liquid still diffuses normally suggests that it is related to the confinement of the GB pre-melt layers by the surrounding crystalline environment. Furthermore, we show that this behavior can be characterized by continuous-time random walk models in which the waiting-time distributions decay according to power-laws that are very similar to those describing dynamics in glass-forming systems.

  17. Predicting First Traversal Times for Virions and Nanoparticles in Mucus with Slowed Diffusion

    PubMed Central

    Erickson, Austen M.; Henry, Bruce I.; Murray, John M.; Klasse, Per Johan; Angstmann, Christopher N.

    2015-01-01

    Particle-tracking experiments focusing on virions or nanoparticles in mucus have measured mean-square displacements and reported diffusion coefficients that are orders of magnitude smaller than the diffusion coefficients of such particles in water. Accurate description of this subdiffusion is important to properly estimate the likelihood of virions traversing the mucus boundary layer and infecting cells in the epithelium. However, there are several candidate models for diffusion that can fit experimental measurements of mean-square displacements. We show that these models yield very different estimates for the time taken for subdiffusive virions to traverse through a mucus layer. We explain why fits of subdiffusive mean-square displacements to standard diffusion models may be misleading. Relevant to human immunodeficiency virus infection, using computational methods for fractional subdiffusion, we show that subdiffusion in normal acidic mucus provides a more effective barrier against infection than previously thought. By contrast, the neutralization of the mucus by alkaline semen, after sexual intercourse, allows virions to cross the mucus layer and reach the epithelium in a short timeframe. The computed barrier protection from fractional subdiffusion is some orders of magnitude greater than that derived by fitting standard models of diffusion to subdiffusive data. PMID:26153713

  18. Normal versus anomalous self-diffusion in two-dimensional fluids: memory function approach and generalized asymptotic Einstein relation.

    PubMed

    Shin, Hyun Kyung; Choi, Bongsik; Talkner, Peter; Lee, Eok Kyun

    2014-12-07

    Based on the generalized Langevin equation for the momentum of a Brownian particle a generalized asymptotic Einstein relation is derived. It agrees with the well-known Einstein relation in the case of normal diffusion but continues to hold for sub- and super-diffusive spreading of the Brownian particle's mean square displacement. The generalized asymptotic Einstein relation is used to analyze data obtained from molecular dynamics simulations of a two-dimensional soft disk fluid. We mainly concentrated on medium densities for which we found super-diffusive behavior of a tagged fluid particle. At higher densities a range of normal diffusion can be identified. The motion presumably changes to sub-diffusion for even higher densities.

  19. Normal versus anomalous self-diffusion in two-dimensional fluids: Memory function approach and generalized asymptotic Einstein relation

    NASA Astrophysics Data System (ADS)

    Shin, Hyun Kyung; Choi, Bongsik; Talkner, Peter; Lee, Eok Kyun

    2014-12-01

    Based on the generalized Langevin equation for the momentum of a Brownian particle a generalized asymptotic Einstein relation is derived. It agrees with the well-known Einstein relation in the case of normal diffusion but continues to hold for sub- and super-diffusive spreading of the Brownian particle's mean square displacement. The generalized asymptotic Einstein relation is used to analyze data obtained from molecular dynamics simulations of a two-dimensional soft disk fluid. We mainly concentrated on medium densities for which we found super-diffusive behavior of a tagged fluid particle. At higher densities a range of normal diffusion can be identified. The motion presumably changes to sub-diffusion for even higher densities.

  20. Diffusion in randomly perturbed dissipative dynamics

    NASA Astrophysics Data System (ADS)

    Rodrigues, Christian S.; Chechkin, Aleksei V.; de Moura, Alessandro P. S.; Grebogi, Celso; Klages, Rainer

    2014-11-01

    Dynamical systems having many coexisting attractors present interesting properties from both fundamental theoretical and modelling points of view. When such dynamics is under bounded random perturbations, the basins of attraction are no longer invariant and there is the possibility of transport among them. Here we introduce a basic theoretical setting which enables us to study this hopping process from the perspective of anomalous transport using the concept of a random dynamical system with holes. We apply it to a simple model by investigating the role of hyperbolicity for the transport among basins. We show numerically that our system exhibits non-Gaussian position distributions, power-law escape times, and subdiffusion. Our simulation results are reproduced consistently from stochastic continuous time random walk theory.

  1. Diffusive and subdiffusive dynamics of indoor microclimate: a time series modeling.

    PubMed

    Maciejewska, Monika; Szczurek, Andrzej; Sikora, Grzegorz; Wyłomańska, Agnieszka

    2012-09-01

    The indoor microclimate is an issue in modern society, where people spend about 90% of their time indoors. Temperature and relative humidity are commonly used for its evaluation. In this context, the two parameters are usually considered as behaving in the same manner, just inversely correlated. This opinion comes from observation of the deterministic components of temperature and humidity time series. We focus on the dynamics and the dependency structure of the time series of these parameters, without deterministic components. Here we apply the mean square displacement, the autoregressive integrated moving average (ARIMA), and the methodology for studying anomalous diffusion. The analyzed data originated from five monitoring locations inside a modern office building, covering a period of nearly one week. It was found that the temperature data exhibited a transition between diffusive and subdiffusive behavior, when the building occupancy pattern changed from the weekday to the weekend pattern. At the same time the relative humidity consistently showed diffusive character. Also the structures of the dependencies of the temperature and humidity data sets were different, as shown by the different structures of the ARIMA models which were found appropriate. In the space domain, the dynamics and dependency structure of the particular parameter were preserved. This work proposes an approach to describe the very complex conditions of indoor air and it contributes to the improvement of the representative character of microclimate monitoring.

  2. A multidimensional subdiffusion model: An arbitrage-free market

    NASA Astrophysics Data System (ADS)

    Li, Guo-Hua; Zhang, Hong; Luo, Mao-Kang

    2012-12-01

    To capture the subdiffusive characteristics of financial markets, the subordinated process, directed by the inverse α-stale subordinator Sα(t) for 0 < α < 1, has been employed as the model of asset prices. In this article, we introduce a multidimensional subdiffusion model that has a bond and K correlated stocks. The stock price process is a multidimensional subdiffusion process directed by the inverse α-stable subordinator. This model describes the period of stagnation for each stock and the behavior of the dependency between multiple stocks. Moreover, we derive the multidimensional fractional backward Kolmogorov equation for the subordinated process using the Laplace transform technique. Finally, using a martingale approach, we prove that the multidimensional subdiffusion model is arbitrage-free, and also gives an arbitrage-free pricing rule for contingent claims associated with the martingale measure.

  3. Anomalous Surface Diffusion of Protons on Lipid Membranes

    PubMed Central

    Wolf, Maarten G.; Grubmüller, Helmut; Groenhof, Gerrit

    2014-01-01

    The cellular energy machinery depends on the presence and properties of protons at or in the vicinity of lipid membranes. To asses the energetics and mobility of a proton near a membrane, we simulated an excess proton near a solvated DMPC bilayer at 323 K, using a recently developed method to include the Grotthuss proton shuttling mechanism in classical molecular dynamics simulations. We obtained a proton surface affinity of −13.0 ± 0.5 kJ mol−1. The proton interacted strongly with both lipid headgroup and linker carbonyl oxygens. Furthermore, the surface diffusion of the proton was anomalous, with a subdiffusive regime over the first few nanoseconds, followed by a superdiffusive regime. The time- and distance dependence of the proton surface diffusion coefficient within these regimes may also resolve discrepancies between previously reported diffusion coefficients. Our simulations show that the proton anomalous surface diffusion originates from restricted diffusion in two different surface-bound states, interrupted by the occasional bulk-mediated long-range surface diffusion. Although only a DMPC membrane was considered in this work, we speculate that the restrictive character of the on-surface diffusion is highly sensitive to the specific membrane conditions, which can alter the relative contributions of the surface and bulk pathways to the overall diffusion process. Finally, we discuss the implications of our findings for the energy machinery. PMID:24988343

  4. Multiple Diffusion Mechanisms Due to Nanostructuring in Crowded Environments

    PubMed Central

    Sanabria, Hugo; Kubota, Yoshihisa; Waxham, M. Neal

    2007-01-01

    One of the key questions regarding intracellular diffusion is how the environment affects molecular mobility. Mostly, intracellular diffusion has been described as hindered, and the physical reasons for this behavior are: immobile barriers, molecular crowding, and binding interactions with immobile or mobile molecules. Using results from multi-photon fluorescence correlation spectroscopy, we describe how immobile barriers and crowding agents affect translational mobility. To study the hindrance produced by immobile barriers, we used sol-gels (silica nanostructures) that consist of a continuous solid phase and aqueous phase in which fluorescently tagged molecules diffuse. In the case of molecular crowding, translational mobility was assessed in increasing concentrations of 500 kDa dextran solutions. Diffusion of fluorescent tracers in both sol-gels and dextran solutions shows clear evidence of anomalous subdiffusion. In addition, data from the autocorrelation function were analyzed using the maximum entropy method as adapted to fluorescence correlation spectroscopy data and compared with the standard model that incorporates anomalous diffusion. The maximum entropy method revealed evidence of different diffusion mechanisms that had not been revealed using the anomalous diffusion model. These mechanisms likely correspond to nanostructuring in crowded environments and to the relative dimensions of the crowding agent with respect to the tracer molecule. Analysis with the maximum entropy method also revealed information about the degree of heterogeneity in the environment as reported by the behavior of diffusive molecules. PMID:17040979

  5. Anomalous surface diffusion of protons on lipid membranes.

    PubMed

    Wolf, Maarten G; Grubmüller, Helmut; Groenhof, Gerrit

    2014-07-01

    The cellular energy machinery depends on the presence and properties of protons at or in the vicinity of lipid membranes. To asses the energetics and mobility of a proton near a membrane, we simulated an excess proton near a solvated DMPC bilayer at 323 K, using a recently developed method to include the Grotthuss proton shuttling mechanism in classical molecular dynamics simulations. We obtained a proton surface affinity of -13.0 ± 0.5 kJ mol(-1). The proton interacted strongly with both lipid headgroup and linker carbonyl oxygens. Furthermore, the surface diffusion of the proton was anomalous, with a subdiffusive regime over the first few nanoseconds, followed by a superdiffusive regime. The time- and distance dependence of the proton surface diffusion coefficient within these regimes may also resolve discrepancies between previously reported diffusion coefficients. Our simulations show that the proton anomalous surface diffusion originates from restricted diffusion in two different surface-bound states, interrupted by the occasional bulk-mediated long-range surface diffusion. Although only a DMPC membrane was considered in this work, we speculate that the restrictive character of the on-surface diffusion is highly sensitive to the specific membrane conditions, which can alter the relative contributions of the surface and bulk pathways to the overall diffusion process. Finally, we discuss the implications of our findings for the energy machinery. Copyright © 2014 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  6. Transient astronomy with the Gaia satellite.

    PubMed

    Hodgkin, Simon T; Wyrzykowski, Łukasz; Blagorodnova, Nadejda; Koposov, Sergey

    2013-06-13

    Gaia is a cornerstone European Space Agency astrometry space mission and a successor to the Hipparcos mission. Gaia will observe the whole sky for 5 years, providing a serendipitous opportunity for the discovery of large numbers of transient and anomalous events, e.g. supernovae, novae and microlensing events, gamma-ray burst afterglows, fallback supernovae, as well as theoretical or unexpected phenomena. In this paper, we discuss our preparations to use Gaia to search for transients at optical wavelengths, and briefly describe the early detection, classification and prompt publication of anomalous sources.

  7. Anomalous extracellular diffusion in rat cerebellum.

    PubMed

    Xiao, Fanrong; Hrabe, Jan; Hrabetova, Sabina

    2015-05-05

    Extracellular space (ECS) is a major channel transporting biologically active molecules and drugs in the brain. Diffusion-mediated transport of these substances is hindered by the ECS structure but the microscopic basis of this hindrance is not fully understood. One hypothesis proposes that the hindrance originates in large part from the presence of dead-space (DS) microdomains that can transiently retain diffusing molecules. Because previous theoretical and modeling work reported an initial period of anomalous diffusion in similar environments, we expected that brain regions densely populated by DS microdomains would exhibit anomalous extracellular diffusion. Specifically, we targeted granular layers (GL) of rat and turtle cerebella that are populated with large and geometrically complex glomeruli. The integrative optical imaging (IOI) method was employed to evaluate diffusion of fluorophore-labeled dextran (MW 3000) in GL, and the IOI data analysis was adapted to quantify the anomalous diffusion exponent dw from the IOI records. Diffusion was significantly anomalous in rat GL, where dw reached 4.8. In the geometrically simpler turtle GL, dw was elevated but not robustly anomalous (dw = 2.6). The experimental work was complemented by numerical Monte Carlo simulations of anomalous ECS diffusion in several three-dimensional tissue models containing glomeruli-like structures. It demonstrated that both the duration of transiently anomalous diffusion and the anomalous exponent depend on the size of model glomeruli and the degree of their wrapping. In conclusion, we have found anomalous extracellular diffusion in the GL of rat cerebellum. This finding lends support to the DS microdomain hypothesis. Transiently anomalous diffusion also has a profound effect on the spatiotemporal distribution of molecules released into the ECS, especially at diffusion distances on the order of a few cell diameters, speeding up short-range diffusion-mediated signals in less permeable structures. Copyright © 2015 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  8. Self-diffusion in dense granular shear flows.

    PubMed

    Utter, Brian; Behringer, R P

    2004-03-01

    Diffusivity is a key quantity in describing velocity fluctuations in granular materials. These fluctuations are the basis of many thermodynamic and hydrodynamic models which aim to provide a statistical description of granular systems. We present experimental results on diffusivity in dense, granular shear flows in a two-dimensional Couette geometry. We find that self-diffusivities D are proportional to the local shear rate gamma; with diffusivities along the direction of the mean flow approximately twice as large as those in the perpendicular direction. The magnitude of the diffusivity is D approximately gamma;a(2), where a is the particle radius. However, the gradient in shear rate, coupling to the mean flow, and strong drag at the moving boundary lead to particle displacements that can appear subdiffusive or superdiffusive. In particular, diffusion appears to be superdiffusive along the mean flow direction due to Taylor dispersion effects and subdiffusive along the perpendicular direction due to the gradient in shear rate. The anisotropic force network leads to an additional anisotropy in the diffusivity that is a property of dense systems and has no obvious analog in rapid flows. Specifically, the diffusivity is suppressed along the direction of the strong force network. A simple random walk simulation reproduces the key features of the data, such as the apparent superdiffusive and subdiffusive behavior arising from the mean velocity field, confirming the underlying diffusive motion. The additional anisotropy is not observed in the simulation since the strong force network is not included. Examples of correlated motion, such as transient vortices, and Lévy flights are also observed. Although correlated motion creates velocity fields which are qualitatively different from collisional Brownian motion and can introduce nondiffusive effects, on average the system appears simply diffusive.

  9. A toolbox for determining subdiffusive mechanisms

    NASA Astrophysics Data System (ADS)

    Meroz, Yasmine; Sokolov, Igor M.

    2015-04-01

    Subdiffusive processes have become a field of great interest in the last decades, due to amounting experimental evidence of subdiffusive behavior in complex systems, and especially in biological systems. Different physical scenarios leading to subdiffusion differ in the details of the dynamics. These differences are what allow to theoretically reconstruct the underlying physics from the results of observations, and will be the topic of this review. We review the main statistical analyses available today to distinguish between these scenarios, categorizing them according to the relevant characteristics. We collect the available tools and statistical tests, presenting them within a broader perspective. We also consider possible complications such as the subordination of subdiffusive mechanisms. Due to the advances in single particle tracking experiments in recent years, we focus on the relevant case of where the available experimental data is scant, at the level of single trajectories.

  10. Continuous time Black-Scholes equation with transaction costs in subdiffusive fractional Brownian motion regime

    NASA Astrophysics Data System (ADS)

    Wang, Jun; Liang, Jin-Rong; Lv, Long-Jin; Qiu, Wei-Yuan; Ren, Fu-Yao

    2012-02-01

    In this paper, we study the problem of continuous time option pricing with transaction costs by using the homogeneous subdiffusive fractional Brownian motion (HFBM) Z(t)=X(Sα(t)), 0<α<1, here dX(τ)=μX(τ)(2H+σX(τ)dBH(τ), as a model of asset prices, which captures the subdiffusive characteristic of financial markets. We find the corresponding subdiffusive Black-Scholes equation and the Black-Scholes formula for the fair prices of European option, the turnover and transaction costs of replicating strategies. We also give the total transaction costs.

  11. Gradual Crossover from Subdiffusion to Normal Diffusion: A Many-Body Effect in Protein Surface Water

    NASA Astrophysics Data System (ADS)

    Tan, Pan; Liang, Yihao; Xu, Qin; Mamontov, Eugene; Li, Jinglai; Xing, Xiangjun; Hong, Liang

    2018-06-01

    Dynamics of hydration water is essential for the function of biomacromolecules. Previous studies have demonstrated that water molecules exhibit subdiffusion on the surface of biomacromolecules; yet the microscopic mechanism remains vague. Here, by performing neutron scattering, molecular dynamics simulations, and analytic modeling on hydrated perdeuterated protein powders, we found water molecules jump randomly between trapping sites on protein surfaces, whose waiting times obey a broad distribution, resulting in subdiffusion. Moreover, the subdiffusive exponent gradually increases with observation time towards normal diffusion due to a many-body volume-exclusion effect.

  12. Generalized fractional diffusion equations for subdiffusion in arbitrarily growing domains

    NASA Astrophysics Data System (ADS)

    Angstmann, C. N.; Henry, B. I.; McGann, A. V.

    2017-10-01

    The ubiquity of subdiffusive transport in physical and biological systems has led to intensive efforts to provide robust theoretical models for this phenomena. These models often involve fractional derivatives. The important physical extension of this work to processes occurring in growing materials has proven highly nontrivial. Here we derive evolution equations for modeling subdiffusive transport in a growing medium. The derivation is based on a continuous-time random walk. The concise formulation of these evolution equations requires the introduction of a new, comoving, fractional derivative. The implementation of the evolution equation is illustrated with a simple model of subdiffusing proteins in a growing membrane.

  13. Noah, Joseph and Convex Hulls

    NASA Astrophysics Data System (ADS)

    Watkins, N. W.; Chau, Y.; Chapman, S. C.

    2010-12-01

    The idea of describing animal movement by mathematical models based on diffusion and Brownian motion has a long heritage. It has thus been natural to account for those aspects of motion that depart from the Brownian by the use of models incorporating long memory & subdiffusion (“the Joseph effect”) and/or heavy tails & superdiffusion (“the Noah effect”). My own interest in this problem was originally from a geoscience perspective, and was triggered by the need to model time series in space physics where both effects coincide. Subsequently I have been involved in animal foraging studies [e.g. Edwards et al, Nature, 2007]. I will describe some recent work [Watkins et al, PRE, 2009] which studies how fixed-timestep and variable-timestep formulations of anomalous diffusion are related in the presence of heavy tails and long range memory (stable processes versus the CTRW). Quantities for which different scaling relations are predicted between the two approaches are of particular interest, to aid testability. I will also present some of work in progress on the convex hull of anomalously diffusing walkers, inspired by its possible relevance to the idea of home range in biology, and by Randon-Furling et al’s recent analytical results in the Brownian case [PRL, 2009].

  14. Anomalous behaviors during infiltration into heterogeneous porous media

    NASA Astrophysics Data System (ADS)

    Aarão Reis, F. D. A.; Bolster, D.; Voller, V. R.

    2018-03-01

    Flow and transport in heterogeneous porous media often exhibit anomalous behavior. A physical analog example is the uni-directional infiltration of a viscous liquid into a horizontal oriented Hele-Shaw cell containing through thickness flow obstacles; a system designed to mimic a gravel/sand medium with impervious inclusions. When there are no obstacles present or the obstacles form a multi-repeating pattern, the change of the length of infiltration F with time t tends to follow a Fickian like scaling, F ∼t1/2 . In the presence of obstacle fields laid out as Sierpinski carpet fractals, infiltration is anomalous, i.e., F ∼ tn, n ≠ 1/2. Here, we study infiltration into such Hele-Shaw cells. First we investigate infiltration into a square cell containing one fractal carpet and make the observation that it is possible to generate both sub (n < 1/2) and super (n > 1/2) diffusive behaviors within identical heterogeneity configurations. We show that this can be explained in terms of a scaling analysis developed from results of random-walk simulations in fractal obstacles; a result indicating that the nature of the domain boundary controls the exponent n of the resulting anomalous transport. Further, we investigate infiltration into a rectangular cell containing several repeats of a given Sierpinski carpet. At very early times, before the liquid encounters any obstacles, the infiltration is Fickian. When the liquid encounters the first (smallest scale) obstacle the infiltration sharply transitions to sub-diffusive. Subsequently, around the time where the liquid has sampled all of the heterogeneity length scales in the system, there is a rapid transition back to Fickian behavior. An explanation for this second transition is obtained by developing a simplified infiltration model based on the definition of a representative averaged hydraulic conductivity.

  15. Molecular machines operating on the nanoscale: from classical to quantum

    PubMed Central

    2016-01-01

    Summary The main physical features and operating principles of isothermal nanomachines in the microworld, common to both classical and quantum machines, are reviewed. Special attention is paid to the dual, constructive role of dissipation and thermal fluctuations, the fluctuation–dissipation theorem, heat losses and free energy transduction, thermodynamic efficiency, and thermodynamic efficiency at maximum power. Several basic models are considered and discussed to highlight generic physical features. This work examines some common fallacies that continue to plague the literature. In particular, the erroneous beliefs that one should minimize friction and lower the temperature for high performance of Brownian machines, and that the thermodynamic efficiency at maximum power cannot exceed one-half are discussed. The emerging topic of anomalous molecular motors operating subdiffusively but very efficiently in the viscoelastic environment of living cells is also discussed. PMID:27335728

  16. Generalized Langevin equation with a three parameter Mittag-Leffler noise

    NASA Astrophysics Data System (ADS)

    Sandev, Trifce; Tomovski, Živorad; Dubbeldam, Johan L. A.

    2011-10-01

    The relaxation functions for a given generalized Langevin equation in the presence of a three parameter Mittag-Leffler noise are studied analytically. The results are represented by three parameter Mittag-Leffler functions. Exact results for the velocity and displacement correlation functions of a diffusing particle are obtained by using the Laplace transform method. The asymptotic behavior of the particle in the short and long time limits are found by using the Tauberian theorems. It is shown that for large times the particle motion is subdiffusive for β-1<αδ<β, and superdiffusive for β<αδ. Many previously obtained results are recovered. Due to the many parameters contained in the noise term, the model considered in this work may be used to improve the description of data and to model anomalous diffusive processes in complex media.

  17. N -tag probability law of the symmetric exclusion process

    NASA Astrophysics Data System (ADS)

    Poncet, Alexis; Bénichou, Olivier; Démery, Vincent; Oshanin, Gleb

    2018-06-01

    The symmetric exclusion process (SEP), in which particles hop symmetrically on a discrete line with hard-core constraints, is a paradigmatic model of subdiffusion in confined systems. This anomalous behavior is a direct consequence of strong spatial correlations induced by the requirement that the particles cannot overtake each other. Even if this fact has been recognized qualitatively for a long time, up to now there has been no full quantitative determination of these correlations. Here we study the joint probability distribution of an arbitrary number of tagged particles in the SEP. We determine analytically its large-time limit for an arbitrary density of particles, and its full dynamics in the high-density limit. In this limit, we obtain the time-dependent large deviation function of the problem and unveil a universal scaling form shared by the cumulants.

  18. Workshop targets development of geodetic transient detection methods: 2009 SCEC Annual Meeting: Workshop on transient anomalous strain detection; Palm Springs, California, 12-13 September 2009

    USGS Publications Warehouse

    Murray-Moraleda, Jessica R.; Lohman, Rowena

    2010-01-01

    The Southern California Earthquake Center (SCEC) is a community of researchers at institutions worldwide working to improve understanding of earthquakes and mitigate earthquake risk. One of SCEC's priority objectives is to “develop a geodetic network processing system that will detect anomalous strain transients.” Given the growing number of continuously recording geodetic networks consisting of hundreds of stations, an automated means for systematically searching data for transient signals, especially in near real time, is critical for network operations, hazard monitoring, and event response. The SCEC Transient Detection Test Exercise began in 2008 to foster an active community of researchers working on this problem, explore promising methods, and combine effective approaches in novel ways. A workshop was held in California to assess what has been learned thus far and discuss areas of focus as the project moves forward.

  19. Peclet number as affected by molecular diffusion controls transient anomalous transport in alluvial aquifer-aquitard complexes

    USGS Publications Warehouse

    Zhang, Yong; Green, Christopher T.; Tick, Geoffrey R.

    2015-01-01

    This study evaluates the role of the Peclet number as affected by molecular diffusion in transient anomalous transport, which is one of the major knowledge gaps in anomalous transport, by combining Monte Carlo simulations and stochastic model analysis. Two alluvial settings containing either short- or long-connected hydrofacies are generated and used as media for flow and transport modeling. Numerical experiments show that 1) the Peclet number affects both the duration of the power-law segment of tracer breakthrough curves (BTCs) and the transition rate from anomalous to Fickian transport by determining the solute residence time for a given low-permeability layer, 2) mechanical dispersion has a limited contribution to the anomalous characteristics of late-time transport as compared to molecular diffusion due to an almost negligible velocity in floodplain deposits, and 3) the initial source dimensions only enhance the power-law tail of the BTCs at short travel distances. A tempered stable stochastic (TSS) model is then applied to analyze the modeled transport. Applications show that the time-nonlocal parameters in the TSS model relate to the Peclet number, Pe. In particular, the truncation parameter in the TSS model increases nonlinearly with a decrease in Pe due to the decrease of the mean residence time, and the capacity coefficient increases with an increase in molecular diffusion which is probably due to the increase in the number of immobile particles. The above numerical experiments and stochastic analysis therefore reveal that the Peclet number as affected by molecular diffusion controls transient anomalous transport in alluvial aquifer–aquitard complexes.

  20. Linking aquifer spatial properties and non-Fickian transport in mobile-immobile like alluvial settings

    USGS Publications Warehouse

    Zhang, Yong; Green, Christopher T.; Baeumer, Boris

    2014-01-01

    Time-nonlocal transport models can describe non-Fickian diffusion observed in geological media, but the physical meaning of parameters can be ambiguous, and most applications are limited to curve-fitting. This study explores methods for predicting the parameters of a temporally tempered Lévy motion (TTLM) model for transient sub-diffusion in mobile–immobile like alluvial settings represented by high-resolution hydrofacies models. The TTLM model is a concise multi-rate mass transfer (MRMT) model that describes a linear mass transfer process where the transfer kinetics and late-time transport behavior are controlled by properties of the host medium, especially the immobile domain. The intrinsic connection between the MRMT and TTLM models helps to estimate the main time-nonlocal parameters in the TTLM model (which are the time scale index, the capacity coefficient, and the truncation parameter) either semi-analytically or empirically from the measurable aquifer properties. Further applications show that the TTLM model captures the observed solute snapshots, the breakthrough curves, and the spatial moments of plumes up to the fourth order. Most importantly, the a priori estimation of the time-nonlocal parameters outside of any breakthrough fitting procedure provides a reliable “blind” prediction of the late-time dynamics of subdiffusion observed in a spectrum of alluvial settings. Predictability of the time-nonlocal parameters may be due to the fact that the late-time subdiffusion is not affected by the exact location of each immobile zone, but rather is controlled by the time spent in immobile blocks surrounding the pathway of solute particles. Results also show that the effective dispersion coefficient has to be fitted due to the scale effect of transport, and the mean velocity can differ from local measurements or volume averages. The link between medium heterogeneity and time-nonlocal parameters will help to improve model predictability for non-Fickian transport in alluvial settings.

  1. Impacts of northern Tibetan Plateau on East Asian summer rainfall via modulating midlatitude transient eddies

    NASA Astrophysics Data System (ADS)

    Deng, Jiechun; Xu, Haiming; Shi, Ning; Zhang, Leying; Ma, Jing

    2017-08-01

    Roles of the Tibetan Plateau (TP) in forming and changing the seasonal Asian climate system have been widely explored. However, little is known about modulation effects of the TP on extratropical transient eddies (TEs) and subsequent synoptic responses of the East Asian rainfall. In this study, the Community Atmosphere Model version 5.1 coupled with a slab ocean model is employed to highlight the important role of the TP in regulating the upper-tropospheric transient wave train. Comparison between sensitivity experiments with and without the TP shows that the northern TP excites a strong anomalous anticyclone, which shifts the upper-level East Asian westerly jet northward and helps transfer barotropic and baroclinic energy from the mean flow to the synoptic TE flow. The transient wave train is primarily shifted northward by northern TP and is forced to propagate southeastward along the eastern flank of the TP until reaching eastern China. Before the strengthening of monsoonal southerlies, the TP-modulated transient wave train cools the troposphere, which decreases the static stability over northern China. Meanwhile, the associated anomalous warm advection induces ascending motion, leading to excessive rainfall by releasing unstable energy as the southerly strengthens. Due to the southeastward propagation of the wave train, anomalous heavy rainfall subsequently appears over eastern China from north to south, which increases day-to-day rainfall variation in this region. Additionally, occurrence of this upper-tropospheric transient wave train associated with low-level southerly peak is substantially increased by northern TP.

  2. From Weakly Chaotic Dynamics to Deterministic Subdiffusion via Copula Modeling

    NASA Astrophysics Data System (ADS)

    Nazé, Pierre

    2018-03-01

    Copula modeling consists in finding a probabilistic distribution, called copula, whereby its coupling with the marginal distributions of a set of random variables produces their joint distribution. The present work aims to use this technique to connect the statistical distributions of weakly chaotic dynamics and deterministic subdiffusion. More precisely, we decompose the jumps distribution of Geisel-Thomae map into a bivariate one and determine the marginal and copula distributions respectively by infinite ergodic theory and statistical inference techniques. We verify therefore that the characteristic tail distribution of subdiffusion is an extreme value copula coupling Mittag-Leffler distributions. We also present a method to calculate the exact copula and joint distributions in the case where weakly chaotic dynamics and deterministic subdiffusion statistical distributions are already known. Numerical simulations and consistency with the dynamical aspects of the map support our results.

  3. Fractional calculus and morphogen gradient formation

    NASA Astrophysics Data System (ADS)

    Yuste, Santos Bravo; Abad, Enrique; Lindenberg, Katja

    2012-12-01

    Some microscopic models for reactive systems where the reaction kinetics is limited by subdiffusion are described by means of reaction-subdiffusion equations where fractional derivatives play a key role. In particular, we consider subdiffusive particles described by means of a Continuous Time Random Walk (CTRW) model subject to a linear (first-order) death process. The resulting fractional equation is employed to study the developmental biology key problem of morphogen gradient formation for the case in which the morphogens are subdiffusive. If the morphogen degradation rate (reactivity) is constant, we find exponentially decreasing stationary concentration profiles, which are similar to the profiles found when the morphogens diffuse normally. However, for the case in which the degradation rate decays exponentially with the distance to the morphogen source, we find that the morphogen profiles are qualitatively different from the profiles obtained when the morphogens diffuse normally.

  4. Anomalous transport and stochastic processes

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Balescu, R.

    1996-03-01

    The relation between kinetic transport theory and theory of stochastic processes is reviewed. The Langevin equation formalism provides important, but rather limited information about diffusive processes. A quite promising new approach to modeling complex situations, such as transport in incompletely destroyed magnetic surfaces, is provided by the theory of Continuous Time Random Walks (CTRW), which is presented in some detail. An academic test problem is discussed in great detail: transport of particles in a fluctuating magnetic field, in the limit of infinite perpendicular correlation length. The well-known subdiffusive behavior of the Mean Square Displacement (MSD), proportional to t{sup 1/2}, ismore » recovered by a CTRW, but the complete density profile is not. However, the quasilinear approximation of the kinetic equation has the form of a non-Markovian diffusion equation and can thus be generated by a CTRW. 16 refs., 3 figs.« less

  5. Peclet number as affected by molecular diffusion controls transient anomalous transport in alluvial aquifer-aquitard complexes.

    PubMed

    Zhang, Yong; Green, Christopher T; Tick, Geoffrey R

    2015-01-01

    This study evaluates the role of the Peclet number as affected by molecular diffusion in transient anomalous transport, which is one of the major knowledge gaps in anomalous transport, by combining Monte Carlo simulations and stochastic model analysis. Two alluvial settings containing either short- or long-connected hydrofacies are generated and used as media for flow and transport modeling. Numerical experiments show that 1) the Peclet number affects both the duration of the power-law segment of tracer breakthrough curves (BTCs) and the transition rate from anomalous to Fickian transport by determining the solute residence time for a given low-permeability layer, 2) mechanical dispersion has a limited contribution to the anomalous characteristics of late-time transport as compared to molecular diffusion due to an almost negligible velocity in floodplain deposits, and 3) the initial source dimensions only enhance the power-law tail of the BTCs at short travel distances. A tempered stable stochastic (TSS) model is then applied to analyze the modeled transport. Applications show that the time-nonlocal parameters in the TSS model relate to the Peclet number, Pe. In particular, the truncation parameter in the TSS model increases nonlinearly with a decrease in Pe due to the decrease of the mean residence time, and the capacity coefficient increases with an increase in molecular diffusion which is probably due to the increase in the number of immobile particles. The above numerical experiments and stochastic analysis therefore reveal that the Peclet number as affected by molecular diffusion controls transient anomalous transport in alluvial aquifer-aquitard complexes. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. Anomalous diffusion and dynamics of fluorescence recovery after photobleaching in the random-comb model

    NASA Astrophysics Data System (ADS)

    Yuste, S. B.; Abad, E.; Baumgaertner, A.

    2016-07-01

    We address the problem of diffusion on a comb whose teeth display varying lengths. Specifically, the length ℓ of each tooth is drawn from a probability distribution displaying power law behavior at large ℓ ,P (ℓ ) ˜ℓ-(1 +α ) (α >0 ). To start with, we focus on the computation of the anomalous diffusion coefficient for the subdiffusive motion along the backbone. This quantity is subsequently used as an input to compute concentration recovery curves mimicking fluorescence recovery after photobleaching experiments in comblike geometries such as spiny dendrites. Our method is based on the mean-field description provided by the well-tested continuous time random-walk approach for the random-comb model, and the obtained analytical result for the diffusion coefficient is confirmed by numerical simulations of a random walk with finite steps in time and space along the backbone and the teeth. We subsequently incorporate retardation effects arising from binding-unbinding kinetics into our model and obtain a scaling law characterizing the corresponding change in the diffusion coefficient. Finally, we show that recovery curves obtained with the help of the analytical expression for the anomalous diffusion coefficient cannot be fitted perfectly by a model based on scaled Brownian motion, i.e., a standard diffusion equation with a time-dependent diffusion coefficient. However, differences between the exact curves and such fits are small, thereby providing justification for the practical use of models relying on scaled Brownian motion as a fitting procedure for recovery curves arising from particle diffusion in comblike systems.

  7. Numerical calculation on a two-step subdiffusion behavior of lateral protein movement in plasma membranes

    NASA Astrophysics Data System (ADS)

    Sumi, Tomonari; Okumoto, Atsushi; Goto, Hitoshi; Sekino, Hideo

    2017-10-01

    A two-step subdiffusion behavior of lateral movement of transmembrane proteins in plasma membranes has been observed by using single-molecule experiments. A nested double-compartment model where large compartments are divided into several smaller ones has been proposed in order to explain this observation. These compartments are considered to be delimited by membrane-skeleton "fences" and membrane-protein "pickets" bound to the fences. We perform numerical simulations of a master equation using a simple two-dimensional lattice model to investigate the heterogeneous diffusion dynamics behavior of transmembrane proteins within plasma membranes. We show that the experimentally observed two-step subdiffusion process can be described using fence and picket models combined with decreased local diffusivity of transmembrane proteins in the vicinity of the pickets. This allows us to explain the two-step subdiffusion behavior without explicitly introducing nested double compartments.

  8. Fluorescence correlation spectroscopy: the case of subdiffusion.

    PubMed

    Lubelski, Ariel; Klafter, Joseph

    2009-03-18

    The theory of fluorescence correlation spectroscopy is revisited here for the case of subdiffusing molecules. Subdiffusion is assumed to stem from a continuous-time random walk process with a fat-tailed distribution of waiting times and can therefore be formulated in terms of a fractional diffusion equation (FDE). The FDE plays the central role in developing the fluorescence correlation spectroscopy expressions, analogous to the role played by the simple diffusion equation for regular systems. Due to the nonstationary nature of the continuous-time random walk/FDE, some interesting properties emerge that are amenable to experimental verification and may help in discriminating among subdiffusion mechanisms. In particular, the current approach predicts 1), a strong dependence of correlation functions on the initial time (aging); 2), sensitivity of correlation functions to the averaging procedure, ensemble versus time averaging (ergodicity breaking); and 3), that the basic mean-squared displacement observable depends on how the mean is taken.

  9. Crowding Induces Complex Ergodic Diffusion and Dynamic Elongation of Large DNA Molecules

    PubMed Central

    Chapman, Cole D.; Gorczyca, Stephanie; Robertson-Anderson, Rae M.

    2015-01-01

    Despite the ubiquity of molecular crowding in living cells, the effects of crowding on the dynamics of genome-sized DNA are poorly understood. Here, we track single, fluorescent-labeled large DNA molecules (11, 115 kbp) diffusing in dextran solutions that mimic intracellular crowding conditions (0–40%), and determine the effects of crowding on both DNA mobility and conformation. Both DNAs exhibit ergodic Brownian motion and comparable mobility reduction in all conditions; however, crowder size (10 vs. 500 kDa) plays a critical role in the underlying diffusive mechanisms and dependence on crowder concentration. Surprisingly, in 10-kDa dextran, crowder influence saturates at ∼20% with an ∼5× drop in DNA diffusion, in stark contrast to exponentially retarded mobility, coupled to weak anomalous subdiffusion, with increasing concentration of 500-kDa dextran. Both DNAs elongate into lower-entropy states (compared to random coil conformations) when crowded, with elongation states that are gamma distributed and fluctuate in time. However, the broadness of the distribution of states and the time-dependence and length scale of elongation length fluctuations depend on both DNA and crowder size with concentration having surprisingly little impact. Results collectively show that mobility reduction and coil elongation of large crowded DNAs are due to a complex interplay between entropic effects and crowder mobility. Although elongation and initial mobility retardation are driven by depletion interactions, subdiffusive dynamics, and the drastic exponential slowing of DNA, up to ∼300×, arise from the reduced mobility of larger crowders. Our results elucidate the highly important and widely debated effects of cellular crowding on genome-sized DNA. PMID:25762333

  10. Organization of extratropical transients during El Nino

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hoerling, M.P.; Ting, Mingfang

    Four observed El Nino-Southern Oscillation (ENSO) events are studied to determine the mechanisms responsible for the anomalous extratropical atmospheric circulation during northern winter. A parallel analysis of a GCM's response to El Nino is performed in order to assess if similar mechanisms are operative in the model atmosphere. The observed stationary wave anomalies over the Pacific/North American (PNA) region are found to be similar during the four winters despite appreciable differences in sea surface temperatures. The anomalous transient vorticity fluxes are remarkably robust over the North Pacific during each even, with an eastward extension of the climatological storm track leadingmore » to strong cyclonic forcing near 40[degrees]N, 150[degrees]W. This forcing is in phase with the seasonal mean Aleutian trough anomaly suggesting the important of eddy-mean flow interaction. By comparison, the intersample variability of the GCM response over the PNA region is found to exceed the observed inter-El Nino variability. This stems primarily from a large variability in the model's anomalous transients over the North Pacific. Further analysis reveals that extratropical vorticity transients are the primary mechanism maintaining the stationary wave anomalies over the PNA region during all four observed ENSO winters. In the case of the GCM, the organization of transient eddies is ill defined over the North Pacific, a behavior indicative of model error. A physical model is proposed to explain the robustness of the tropical controlling influence of the extratropical transients in nature. A simple equatorial Pacific heat source directly forces a tropical anticyclone whose phase relative to the climatological tropical anticyclone leads to an eastward extension of the subtropical jet stream. This mechanism appears to be equally effective for a heat source located either in the central or eastern Pacific basin. 36 refs., 14 figs.« less

  11. A proposed origin for palimpsests and anomalous pit craters on Ganymede and Callisto

    NASA Technical Reports Server (NTRS)

    Croft, S. K.

    1983-01-01

    The hypothesis that palimpsests and anomalous pit craters are essentially pristine crater forms derived from high-velocity impacts and/or impacts into an ice crust with preimpact temperatures near melting is explored. The observational data are briefly reviewed, and an impact model is proposed for the direct formation of a palimpsest from an impact when the modification flow which produces the final crater is dominated by 'wet' fluid flow, as opposed to the 'dry' granular flow which produces normal craters. Conditions of 'wet' modification occur when the volume of impact melt remaining in the transient crater attains a volume comparable to the transient crater. The normal crater-palimpsest transition is found to occur for sufficiently large impacts or sufficiently fast impactors. The range of crater diameters and morphological characteristics inferred from the impact model is consistent with the observed characteristics of palimpsests and anomalous pit craters.

  12. The role of fractional time-derivative operators on anomalous diffusion

    NASA Astrophysics Data System (ADS)

    Tateishi, Angel A.; Ribeiro, Haroldo V.; Lenzi, Ervin K.

    2017-10-01

    The generalized diffusion equations with fractional order derivatives have shown be quite efficient to describe the diffusion in complex systems, with the advantage of producing exact expressions for the underlying diffusive properties. Recently, researchers have proposed different fractional-time operators (namely: the Caputo-Fabrizio and Atangana-Baleanu) which, differently from the well-known Riemann-Liouville operator, are defined by non-singular memory kernels. Here we proposed to use these new operators to generalize the usual diffusion equation. By analyzing the corresponding fractional diffusion equations within the continuous time random walk framework, we obtained waiting time distributions characterized by exponential, stretched exponential, and power-law functions, as well as a crossover between two behaviors. For the mean square displacement, we found crossovers between usual and confined diffusion, and between usual and sub-diffusion. We obtained the exact expressions for the probability distributions, where non-Gaussian and stationary distributions emerged. This former feature is remarkable because the fractional diffusion equation is solved without external forces and subjected to the free diffusion boundary conditions. We have further shown that these new fractional diffusion equations are related to diffusive processes with stochastic resetting, and to fractional diffusion equations with derivatives of distributed order. Thus, our results suggest that these new operators may be a simple and efficient way for incorporating different structural aspects into the system, opening new possibilities for modeling and investigating anomalous diffusive processes.

  13. Portable measurement system for real-time acquisition and analysis of in-vivo spatially resolved reflectance in the subdiffusive regime

    NASA Astrophysics Data System (ADS)

    Naglič, Peter; Ivančič, Matic; Pernuš, Franjo; Likar, Boštjan; Bürmen, Miran

    2018-02-01

    A measurement system was developed to acquire and analyze subdiffusive spatially resolved reflectance using an optical fiber probe with short source-detector separations. Since subdiffusive reflectance significantly depends on the scattering phase function, the analysis of the acquired reflectance is based on a novel inverse Monte Carlo model that allows estimation of phase function related parameters in addition to the absorption and reduced scattering coefficients. In conjunction with our measurement system, the model allowed real-time estimation of optical properties, which we demonstrate for a case of dynamically induced changes in human skin by applying pressure with an optical fiber probe.

  14. A Bond-Fluctuation Model of Translational Dynamics of Chain-like Particles through Mucosal Scaffolds.

    PubMed

    Bajd, Franci; Serša, Igor

    2018-06-05

    Mucus scaffolds represent one of the most common barriers in targeted drug delivery and can remarkably reduce the outcome of pharmacological therapies. An efficient transport of drug particles through a mucus barrier is a precondition for an efficient drug delivery. Understanding the transport mechanism is particularly important for treatment of disorders such as cystic fibrosis. These are characterized by an onset of high-density mucus scaffolds imposing an increased steric filtering. In this study, we employed the bond-fluctuation model to analyze the effect of steric interactions on slowing the translational dynamics of compound chain-like particles traversing through scaffolds of different configurations (regular isotropic and anisotropic versus irregular random). The model, which accounts for both the geometry-imposed steric interaction as well as the intrachain steric interaction between the chain subunits, yields a transient subdiffusive motional pattern persists between the short-time and long-time Gaussian diffusion limits. The motion is analyzed in terms of a mean-squared displacement, diffusion coefficient, and radius of gyration. With higher levels of restriction or larger particles, the subdiffusive motional regime persists longer. The study also demonstrates that an important feature of the motion is also geometry-induced chain accommodation. The presented model is generic and could also be applied to studying the translational dynamics of other particles with more complex architecture such as dendrites or chain-decorated nanoparticles. Copyright © 2018 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  15. Subdiffusion kinetics of nanoprecipitate growth and destruction in solid solutions

    NASA Astrophysics Data System (ADS)

    Sibatov, R. T.; Svetukhin, V. V.

    2015-06-01

    Based on fractional differential generalizations of the Ham and Aaron-Kotler precipitation models, we study the kinetics of subdiffusion-limited growth and dissolution of new-phase precipitates. We obtain the time dependence of the number of impurities and dimensions of new-phase precipitates. The solutions agree with the Monte Carlo simulation results.

  16. Subdiffusive motion of bacteriophage in mucosal surfaces increases the frequency of bacterial encounters.

    PubMed

    Barr, Jeremy J; Auro, Rita; Sam-Soon, Nicholas; Kassegne, Sam; Peters, Gregory; Bonilla, Natasha; Hatay, Mark; Mourtada, Sarah; Bailey, Barbara; Youle, Merry; Felts, Ben; Baljon, Arlette; Nulton, Jim; Salamon, Peter; Rohwer, Forest

    2015-11-03

    Bacteriophages (phages) defend mucosal surfaces against bacterial infections. However, their complex interactions with their bacterial hosts and with the mucus-covered epithelium remain mostly unexplored. Our previous work demonstrated that T4 phage with Hoc proteins exposed on their capsid adhered to mucin glycoproteins and protected mucus-producing tissue culture cells in vitro. On this basis, we proposed our bacteriophage adherence to mucus (BAM) model of immunity. Here, to test this model, we developed a microfluidic device (chip) that emulates a mucosal surface experiencing constant fluid flow and mucin secretion dynamics. Using mucus-producing human cells and Escherichia coli in the chip, we observed similar accumulation and persistence of mucus-adherent T4 phage and nonadherent T4∆hoc phage in the mucus. Nevertheless, T4 phage reduced bacterial colonization of the epithelium >4,000-fold compared with T4∆hoc phage. This suggests that phage adherence to mucus increases encounters with bacterial hosts by some other mechanism. Phages are traditionally thought to be completely dependent on normal diffusion, driven by random Brownian motion, for host contact. We demonstrated that T4 phage particles displayed subdiffusive motion in mucus, whereas T4∆hoc particles displayed normal diffusion. Experiments and modeling indicate that subdiffusive motion increases phage-host encounters when bacterial concentration is low. By concentrating phages in an optimal mucus zone, subdiffusion increases their host encounters and antimicrobial action. Our revised BAM model proposes that the fundamental mechanism of mucosal immunity is subdiffusion resulting from adherence to mucus. These findings suggest intriguing possibilities for engineering phages to manipulate and personalize the mucosal microbiome.

  17. Anomalous high-frequency wave activity flux preceding anomalous changes in the Northern polar jet

    NASA Astrophysics Data System (ADS)

    Nakamura, Mototaka; Kadota, Minoru; Yamane, Shozo

    2010-05-01

    Anomalous forcing by quasi-geostrophic (QG) waves has been reported as an important forcing factor in the Northern Annular Mode (NAM) in recent literatures. In order to shed a light on the dynamics of the NAM from a different angle, we have examined anomalous behavior of the winter jets in the upper troposphere and stratosphere by focusing our diagnosis on not the anomalous geopotential height (Z) itself, but on the anomalous change in the Z (dZ) between two successive months and preceding transient QG wave activity flux during the cold season. We calculated EOFs of dZ between two successive months at 150hPa for a 46-year period, from 1958 to 2003, using the monthly mean NCEP reanalysis data. We then formed anomaly composites of changes in Z and the zonal velocity (U), as well as the preceding and following wave activity flux, Z, U, and temperature at various heights, for both positive and negative phases of the first EOF. For the wave forcing fields, we adopted the diagnostic system for the three-dimensional QG transient wave activity flux in the zonally-varying three-dimensional mean flow developed by Plumb (1986) with a slight modification in its application to the data. Our choice of the Plumb86 is based on the fact that the winter mean flow in the Northern Hemisphere is characterized by noticeable zonal asymmetry, and has a symbiotic relationship with waves in the extra-tropics. The Plumb86 flux was calculated for high-frequency (period of 2 to 7 days) and low-frequency (period of 10 to 20 days) waves with the ultra-low-frequency (period of 30 days or longer) flow as the reference state for each time frame of the 6 hourly NCEP reanalysis data from 1958 to 2003. By replacing the mean flow with the ultra-low-frequency flow in the application of the Plumb86 formula, the flux fields were calculated as time series at 6 hour intervals. The time series of the wave activity flux was then averaged for each month. The patterns of composited anomalous dZ and dU clearly show anomalous acceleration or deceleration of U in the polar region, accompanied by anomalies of the opposite sign in the subtropics throughout the troposphere and stratosphere. The anomalies are conspicuously large in the polar stratosphere. The composited anomalous Z and U in the preceding and following months indicate that these large anomalies in dZ and dU occur when the polar troposphere and stratosphere are relaxing back toward the climatology from strongly anomalous states that closely resemble the positive and negative phases of the NAM. In this process of relaxation, the atmosphere actually overshoots the climatology and develops anomalies of the sign opposite to those existed initially. The anomalous wave activity flux exhibit strong signals of anomalous upward (downward) propagation of high-frequency waves in the North Atlantic storm track from the bottom of the atmosphere, penetrating up to the stratosphere, when the polar jet is anomalously strong (weak) in the preceding month. The anomalous horizontal wave activity flux shows anomalous eastward (westward) flux emanating from the North Atlantic storm track when the polar jet is anomalously strong (weak) in the preceding month. These patterns suggest that anomalous high-frequency waves originating from the North Atlantic storm track in the lower troposphere contribute to the destruction of both phases of the NAM. However, the anomalous flux divergence is very noisy everywhere due to the noisiness of the advective horizontal flux, making it difficult to ascertain the role of the high-frequency transients in the destruction of the NAM.

  18. Final Cassini RADAR Observation of Titan's Magic Island Region and Ligeia Mare

    NASA Astrophysics Data System (ADS)

    Hofgartner, J. D.; Hayes, A.; Lunine, J. I.; Stiles, B. W.; Malaska, M. J.; Wall, S. D.

    2017-12-01

    Cassini arrived in the Saturn system shortly after the Oct. 2002 northern winter solstice and the mission will end shortly after the May 2017 northern summer solstice. A main objective of the Cassini Solstice mission is to study seasonal and temporal changes and at Titan this includes changes of the hydrocarbon lakes/seas. Titan's Magic Islands are transient bright features in the north polar sea, Ligeia Mare that were observed to be temporal changes in Cassini RADAR images. The Magic Islands were discovered in a July 2013 image as anomalously bright features that were not present in four previous observations from Feb. 2007 - May 2013. The region of the Magic Islands was again anomalously bright in an Aug. 2014 image and the total areal extent of the anomalously bright region had increased by more than a factor of three. The transient features were not, however, observed in a Jan. 2015 image. Thus in seven observations spanning much of the Cassini mission the bright features were observed to appear, increase in extent, and then disappear. They are referred to as Titan's Magic Islands because of their appearing/disappearing behavior and resemblance in appearance to islands. These transient bright features are not actually islands. The transients were concluded to be most consistent with waves, floating solids, suspended solids, and bubbles. Tides, sea level changes, and seafloor changes are unlikely to be the primary cause of these temporal changes. Whether these temporal changes are also seasonal changes was unclear. The final Cassini RADAR imaging observation of Titan in Apr. 2017 included the region of the Magic Islands. The transient bright features were not present during this observation. The geometry of the observation was such that, had the transients been present, their brightness may have ruled out some of the remaining hypotheses. Their absence however, is less constraining but consistent with their transient nature. Waves, floating solids, suspended solids, and bubbles remain the most likely hypotheses. Other regions of Ligeia Mare were also imaged in the Apr. 2017 observation and no transient features were observed elsewhere in the sea. The specific process responsible for these transient features and the role of seasonal changes in their appearance and disappearance remains an open research question.

  19. New fluorescence correlation spectroscopy enabling direct observation of spatiotemporal dependence of diffusion constants as an evidence of anomalous transport in extracellular matrices.

    PubMed

    Masuda, Akiko; Ushida, Kiminori; Okamoto, Takayuki

    2005-05-01

    The potential of fluorescence correlation spectroscopy (FCS) is extended to enable the direct observation of anomalous subdiffusion (ASD) in inhomogeneous media that are of great importance particularly in many biological systems, such as membranes, cytoplasm, and extracellular matrices (ECMs). Because ASD can be confirmed by monitoring the spatiotemporal dependence of observable diffusion coefficients (D(obs)), the size of the effective confocal volume (V(eff)) for FCS sampling (sampling volume) was continuously changed on a scale of 300-500 nm using a motorized variable beam expander through which an illuminating laser beam passes. This new method, namely, sampling-volume-controlled (SVC)-FCS, was applied to the analysis of hyaluronan (HA) aqueous solutions where the D(obs) of light-emitting solute (Alexa 488) markedly changed, corresponding to the change in V(eff) (220-340 nm in the half-axis), because the network structure of HA of 7-33 nm (nanostructure) interferes with the material transport within it. The results indicate that moderate ASD may occur even in the presence of a small amount ( approximately 0.1 wt %) of HA in ECM. Because the change in D(obs) along with the traveling distance (the mean-square displacement) can be identified even in systems with no deformation of the autocorrelation function, this technique has a great potential for general applications to many biological systems in which ASD shows complex time and space dependences.

  20. Analysis of Bacteriophage Motion Through a Non-Static Medium

    NASA Astrophysics Data System (ADS)

    Dickey, Samuel A.

    In this work, I investigated the motion of bacteriophages (phages) through their mucosal environment. Recently, biologists here at San Diego State University have proposed a model in which phages move sub-diffusively through mucosal fibers in their hunt for bacteria to prey upon. Through a Hoc protein located upon the capsid of the wild type phages, these phages are allowed to bind to mucosal fibers, and extend the amount of time spent in a single location hunting for bacteria. Contrarily, the delta hoc phages are unable to. The ability of the wild type phages to attach itself to mucosal fibers is what enables its subdiffusive behavior. This study investigates the diffusive behavior of these phages in different mucus concentrations. It expands on previous studies in which only short tracks could be observed. In the study at hand, phages are imaged in a highly doped optical fiber with varying concentrations of mucus present in solution. Through rigorous image processing techniques, trajectories of these phages are created with a minimized noise level. We developed code that created position-versus-time files for each phage present in the experimental data. These files were then further analyzed. The sub-diffusive behavior is investigated via mean squared displacement versus time. The diffusive exponent can be obtained from fits to these data. For large enough time intervals, I always obtained an exponent of one for space and time averaged data. This indicates that the diffusion is normal, or sub-diffusive of the CTRW type. CTRW sub-diffusive motion is characterized by waiting times that resemble a power law distribution and have long tails. I investigate these stuck time distributions, however am unable to determine if a power law or exponential fits the data best. Moreover, the distribution gives the same power law exponent for phages moving through water, or mucus, for wild type and delta hoc phages. These exponents would predict super-diffusive instead of sub-diffusive behavior. We conclude that many of these problems result from the small amount of data available to us and the still primitive conditions of the setup at the time the data were collected.

  1. Diffusion, subdiffusion, and localization of active colloids in random post lattices

    NASA Astrophysics Data System (ADS)

    Morin, Alexandre; Lopes Cardozo, David; Chikkadi, Vijayakumar; Bartolo, Denis

    2017-10-01

    Combining experiments and theory, we address the dynamics of self-propelled particles in crowded environments. We first demonstrate that motile colloids cruising at constant speed through random lattices undergo a smooth transition from diffusive to subdiffusive to localized dynamics upon increasing the obstacle density. We then elucidate the nature of these transitions by performing extensive simulations constructed from a detailed analysis of the colloid-obstacle interactions. We evidence that repulsion at a distance and hard-core interactions both contribute to slowing down the long-time diffusion of the colloids. In contrast, the localization transition stems solely from excluded-volume interactions and occurs at the void-percolation threshold. Within this critical scenario, equivalent to that of the random Lorentz gas, genuine asymptotic subdiffusion is found only at the critical density where the motile particles explore a fractal maze.

  2. Strongly anomalous diffusion in sheared magnetic configurations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Vanden Eijnden, E.; Balescu, R.

    1996-03-01

    The statistical behavior of magnetic lines in a sheared magnetic configuration with reference surface {ital x}=0 is investigated within the framework of the kinetic theory. A Liouville equation is associated with the equations of motion of the stochastic magnetic lines. After averaging over an ensemble of realizations, it yields a convection-diffusion equation within the quasilinear approximation. The diffusion coefficients are space dependent and peaked around the reference surface {ital x}=0. Due to the shear, the diffusion of lines away from the reference surface is slowed down. The behavior of the lines is asymptotically strongly non-Gaussian. The reference surface acts likemore » an attractor around which the magnetic lines spread with an effective subdiffusive behavior. Comparison is also made with more usual treatments based on the study of the first two moments equations. For sheared systems, it is explicitly shown that the Corrsin approximation assumed in the latter approach is no longer valid. It is also concluded that the diffusion coefficients cannot be derived from the mean square displacement of the magnetic lines in an inhomogeneous medium. {copyright} {ital 1996 American Institute of Physics.}« less

  3. Fluctuating bottleneck model studies on kinetics of DNA escape from α-hemolysin nanopores

    NASA Astrophysics Data System (ADS)

    Bian, Yukun; Wang, Zilin; Chen, Anpu; Zhao, Nanrong

    2015-11-01

    We have proposed a fluctuation bottleneck (FB) model to investigate the non-exponential kinetics of DNA escape from nanometer-scale pores. The basic idea is that the escape rate is proportional to the fluctuating cross-sectional area of DNA escape channel, the radius r of which undergoes a subdiffusion dynamics subjected to fractional Gaussian noise with power-law memory kernel. Such a FB model facilitates us to obtain the analytical result of the averaged survival probability as a function of time, which can be directly compared to experimental results. Particularly, we have applied our theory to address the escape kinetics of DNA through α-hemolysin nanopores. We find that our theoretical framework can reproduce the experimental results very well in the whole time range with quite reasonable estimation for the intrinsic parameters of the kinetics processes. We believe that FB model has caught some key features regarding the long time kinetics of DNA escape through a nanopore and it might provide a sound starting point to study much wider problems involving anomalous dynamics in confined fluctuating channels.

  4. Spontaneous Mechanical Buckling in Two-Dimensional Materials: A Power Source for Ambient Vibration Energy Harvesters

    NASA Astrophysics Data System (ADS)

    Thibado, Paul; Kumar, Pradeep; Singh, Surendra

    Internet-of-Things (IoT) is projected to become a multi-trillion-dollar market, but most applications cannot afford replacing batteries on such a large scale, driving the need for battery alternatives. We recently discovered that freestanding graphene membranes are in perpetual motion when held at room temperature. Surprisingly, the random up-down motion of the membrane does not follow classical Brownian motion, but instead is super-diffusive at short times and sub-diffusive at long times. Furthermore, the velocity probability distribution function is non-Gaussian and follows the heavy-tailed Cauchy-Lorentz distribution, consistent with Lévy flights. Molecular dynamics simulations reveal that mechanical buckling is spontaneously occurring, and that this is the mechanism responsible for the anomalous movement. Bucking in this system occurs when the local material suddenly flips from concave to convex. The higher kinetic energy associated with this motion is derived from the surrounding thermal waste heat, and it may be converted into an electrical current and used as the active component of small power generators known as ambient vibration energy harvesters. thibado@uark.edu.

  5. A fast semi-discrete Kansa method to solve the two-dimensional spatiotemporal fractional diffusion equation

    NASA Astrophysics Data System (ADS)

    Sun, HongGuang; Liu, Xiaoting; Zhang, Yong; Pang, Guofei; Garrard, Rhiannon

    2017-09-01

    Fractional-order diffusion equations (FDEs) extend classical diffusion equations by quantifying anomalous diffusion frequently observed in heterogeneous media. Real-world diffusion can be multi-dimensional, requiring efficient numerical solvers that can handle long-term memory embedded in mass transport. To address this challenge, a semi-discrete Kansa method is developed to approximate the two-dimensional spatiotemporal FDE, where the Kansa approach first discretizes the FDE, then the Gauss-Jacobi quadrature rule solves the corresponding matrix, and finally the Mittag-Leffler function provides an analytical solution for the resultant time-fractional ordinary differential equation. Numerical experiments are then conducted to check how the accuracy and convergence rate of the numerical solution are affected by the distribution mode and number of spatial discretization nodes. Applications further show that the numerical method can efficiently solve two-dimensional spatiotemporal FDE models with either a continuous or discrete mixing measure. Hence this study provides an efficient and fast computational method for modeling super-diffusive, sub-diffusive, and mixed diffusive processes in large, two-dimensional domains with irregular shapes.

  6. The North Pacific as a Regulator of Summertime Climate Over North America and the Asian Monsoon

    NASA Technical Reports Server (NTRS)

    Lau, William K. M.; Wang, H.

    2004-01-01

    The interannual variability of summertime rainfall over the U.S. may be linked to climate anomalies over Pacific and East Asia through teleconnection patterns that may be components of recurring global climate modes in boreal summer (Lau and Weng 2002). In this study, maintenance of the boreal summer teleconnection patterns is investigated. The particular focus is on the potential effects of North Pacific air-sea interaction on climate anomalies over the U.S. Observational data, reanalysis and outputs of a series of NASA NSIPP AGCM and AGCM coupled to NASA GSFC MLO model experiments are used. Statistical analysis of observations and NSIPP AMIP type simulations indicates that, the interannual variability of observed warm season precipitation over the U.S. is related to SST variation in both tropical and North Pacific, whereas the NSIPP AMIP simulated summertime US. precipitation variation mainly reflects impact of ENS0 in tropical Pacific. This implies the potential importance of air-sea interaction in North Pacific in contributing to the interannual variability of observed summer climate over the U.S. The anomalous atmospheric circulation associated with the dominant summertime teleconnection modes in both observations and NSIPP AMIP simulations are further diagnosed, using stationary wave modeling approach. In observations, for the two dominant modes, both anomalous diabatic heating and anomalous transients significantly contribute to the anomalous circulation. The distributions of the anomalous diabatic heating and transient forcing are quadrature configured over North Pacific and North America, so that both forcings act constructively to maintain the teleconnection patterns. The contrast between observations and NSIPP AMIP simulations from stationary wave modeling diagnosis confirms the previous conclusion based on statistical analysis. To better appreciate the role of extra-tropical air-sea interaction in maintaining the summertime teleconnection pattern, various dynamical and physical fields and their inter- linkage in the series of NSIPP AGCM and AGCM coupled to MLO model experiments are examined in-depth. Based on comparison between different model experiments, we will discuss the physical and dynamical mechanisms through which the air-sea interaction in extratropics, and transient mean flow interactions over the North Pacific, affects interannual variation of U.S. climate during boreal summer.

  7. Classification of nanoparticle diffusion processes in vital cells by a multifeature random forests approach: application to simulated data, darkfield, and confocal laser scanning microscopy

    NASA Astrophysics Data System (ADS)

    Wagner, Thorsten; Kroll, Alexandra; Wiemann, Martin; Lipinski, Hans-Gerd

    2016-04-01

    Darkfield and confocal laser scanning microscopy both allow for a simultaneous observation of live cells and single nanoparticles. Accordingly, a characterization of nanoparticle uptake and intracellular mobility appears possible within living cells. Single particle tracking makes it possible to characterize the particle and the surrounding cell. In case of free diffusion, the mean squared displacement for each trajectory of a nanoparticle can be measured which allows computing the corresponding diffusion coefficient and, if desired, converting it into the hydrodynamic diameter using the Stokes-Einstein equation and the viscosity of the fluid. However, within the more complex system of a cell's cytoplasm unrestrained diffusion is scarce and several other types of movements may occur. Thus, confined or anomalous diffusion (e.g. diffusion in porous media), active transport, and combinations thereof were described by several authors. To distinguish between these types of particle movement we developed an appropriate classification method, and simulated three types of particle motion in a 2D plane using a Monte Carlo approach: (1) normal diffusion, using random direction and step-length, (2) subdiffusion, using confinements like a reflective boundary with defined radius or reflective objects in the closer vicinity, and (3) superdiffusion, using a directed flow added to the normal diffusion. To simulate subdiffusion we devised a new method based on tracks of different length combined with equally probable obstacle interaction. Next we estimated the fractal dimension, elongation and the ratio of long-time / short-time diffusion coefficients. These features were used to train a random forests classification algorithm. The accuracy for simulated trajectories with 180 steps was 97% (95%-CI: 0.9481-0.9884). The balanced accuracy was 94%, 99% and 98% for normal-, sub- and superdiffusion, respectively. Nanoparticle tracking analysis was used with 100 nm polystyrene particles to get trajectories for normal diffusion. As a next step we identified diffusion types of nanoparticles in vital cells and incubated V79 fibroblasts with 50 nm gold nanoparticles, which appeared as intensely bright objects due to their surface plasmon resonance. The movement of particles in both the extracellular and intracellular space was observed by dark field and confocal laser scanning microscopy. After reducing background noise from the video it became possible to identify individual particle spots by a maximum detection algorithm and trace them using the robust single-particle tracking algorithm proposed by Jaqaman, which is able to handle motion heterogeneity and particle disappearance. The particle trajectories inside cells indicated active transport (superdiffusion) as well as subdiffusion. Eventually, the random forest classification algorithm, after being trained by the above simulations, successfully classified the trajectories observed in live cells.

  8. Fractal analysis of lateral movement in biomembranes.

    PubMed

    Gmachowski, Lech

    2018-04-01

    Lateral movement of a molecule in a biomembrane containing small compartments (0.23-μm diameter) and large ones (0.75 μm) is analyzed using a fractal description of its walk. The early time dependence of the mean square displacement varies from linear due to the contribution of ballistic motion. In small compartments, walking molecules do not have sufficient time or space to develop an asymptotic relation and the diffusion coefficient deduced from the experimental records is lower than that measured without restrictions. The model makes it possible to deduce the molecule step parameters, namely the step length and time, from data concerning confined and unrestricted diffusion coefficients. This is also possible using experimental results for sub-diffusive transport. The transition from normal to anomalous diffusion does not affect the molecule step parameters. The experimental literature data on molecular trajectories recorded at a high time resolution appear to confirm the modeled value of the mean free path length of DOPE for Brownian and anomalous diffusion. Although the step length and time give the proper values of diffusion coefficient, the DOPE speed calculated as their quotient is several orders of magnitude lower than the thermal speed. This is interpreted as a result of intermolecular interactions, as confirmed by lateral diffusion of other molecules in different membranes. The molecule step parameters are then utilized to analyze the problem of multiple visits in small compartments. The modeling of the diffusion exponent results in a smooth transition to normal diffusion on entering a large compartment, as observed in experiments.

  9. Self-crowding of AMPA receptors in the excitatory postsynaptic density can effectuate anomalous receptor sub-diffusion.

    PubMed

    Gupta, Rahul

    2018-02-01

    AMPA receptors (AMPARs) and their associations with auxiliary transmembrane proteins are bulky structures with large steric-exclusion volumes. Hence, self-crowding of AMPARs, depending on the local density, may affect their lateral diffusion in the postsynaptic membrane as well as in the highly crowded postsynaptic density (PSD) at excitatory synapses. Earlier theoretical studies considered only the roles of transmembrane obstacles and the AMPAR-binding submembranous scaffold proteins in shaping receptor diffusion within PSD. Using lattice model of diffusion, the present study investigates the additional impacts of self-crowding on the anomalousity and effective diffusion coefficient (Deff) of AMPAR diffusion. A recursive algorithm for avoiding false self-blocking during diffusion simulation is also proposed. The findings suggest that high density of AMPARs in the obstacle-free membrane itself engenders strongly anomalous diffusion and severe decline in Deff. Adding transmembrane obstacles to the membrane accentuates the anomalousity arising from self-crowding due to the reduced free diffusion space. Contrarily, enhanced AMPAR-scaffold binding, either through increase in binding strength or scaffold density or both, ameliorates the anomalousity resulting from self-crowding. However, binding has differential impacts on Deff depending on the receptor density. Increase in binding causes consistent decrease in Deff for low and moderate receptor density. For high density, binding increases Deff as long as it reduces anomalousity associated with intense self-crowding. Given a sufficiently strong binding condition when diffusion acquires normal behavior, further increase in binding causes decrease in Deff. Supporting earlier experimental observations are mentioned and implications of present findings to the experimental observations on AMPAR diffusion are also drawn.

  10. Resolving mixed mechanisms of protein subdiffusion at the T cell plasma membrane

    NASA Astrophysics Data System (ADS)

    Golan, Yonatan; Sherman, Eilon

    2017-06-01

    The plasma membrane is a complex medium where transmembrane proteins diffuse and interact to facilitate cell function. Membrane protein mobility is affected by multiple mechanisms, including crowding, trapping, medium elasticity and structure, thus limiting our ability to distinguish them in intact cells. Here we characterize the mobility and organization of a short transmembrane protein at the plasma membrane of live T cells, using single particle tracking and photoactivated-localization microscopy. Protein mobility is highly heterogeneous, subdiffusive and ergodic-like. Using mobility characteristics, we segment individual trajectories into subpopulations with distinct Gaussian step-size distributions. Particles of low-to-medium mobility consist of clusters, diffusing in a viscoelastic and fractal-like medium and are enriched at the centre of the cell footprint. Particles of high mobility undergo weak confinement and are more evenly distributed. This study presents a methodological approach to resolve simultaneous mixed subdiffusion mechanisms acting on polydispersed samples and complex media such as cell membranes.

  11. Fractional Brownian motion and motion governed by the fractional Langevin equation in confined geometries.

    PubMed

    Jeon, Jae-Hyung; Metzler, Ralf

    2010-02-01

    Motivated by subdiffusive motion of biomolecules observed in living cells, we study the stochastic properties of a non-Brownian particle whose motion is governed by either fractional Brownian motion or the fractional Langevin equation and restricted to a finite domain. We investigate by analytic calculations and simulations how time-averaged observables (e.g., the time-averaged mean-squared displacement and displacement correlation) are affected by spatial confinement and dimensionality. In particular, we study the degree of weak ergodicity breaking and scatter between different single trajectories for this confined motion in the subdiffusive domain. The general trend is that deviations from ergodicity are decreased with decreasing size of the movement volume and with increasing dimensionality. We define the displacement correlation function and find that this quantity shows distinct features for fractional Brownian motion, fractional Langevin equation, and continuous time subdiffusion, such that it appears an efficient measure to distinguish these different processes based on single-particle trajectory data.

  12. TINY HICCUPS TO TITANIC EXPLOSIONS: Tackling Transients in Anomalous X-ray Pulsars

    NASA Astrophysics Data System (ADS)

    Kaspi, Victoria

    2011-09-01

    The past decade has seen major progress in neutron star astrophysics, with the discovery of magnetars in general, and the recognition that the Anomalous X-ray Pulsars (AXPs) fall in this class. AXPs have recently revealed surprising and dramatic variability behavior, which theorists have begun to show are highly constraining of physical models of magnetars, including their crusts, atmospheres, coronae and magnetospheres. In this proposal, we request Chandra/ACIS-S Target-of-Opportunity observations of one major Anomalous X-ray Pulsar (AXP) outburst in AO13, in order to study in detail the evolution of the spectrum, pulsed fraction and pulse profile, for quantitative confrontation with recently developed models for the structure and electrodynamics of magnetars.

  13. Tiny Tremors to Titanic Explosions: Tackling Transients in Anomalous X-Ray Pulsars

    NASA Astrophysics Data System (ADS)

    Kaspi, Victoria

    We are requesting the target-of-oppurtunity (ToO) component of an ongoing, successful, long-term RXTE monitoring campaign of anomalous X- ray pulsars (AXPs). Their nature had been a mystery, but with our discoveries of X-ray bursts from AXPs, there is compelling evidence that they are young, isolated, ultra-magnetized neutron stars or "magnetars." We request ToO observations of any of the known and candidate AXPs as well as of any newly discovered AXPs should they exhibit anomalous behavior of one or more of the following types: bursts, significant sudden pulse profile changes, glitches or other rotational anomalies, or pulse fractions changes. These observations will allow us to answer basic physical questions about neutron star structure.

  14. TINY HICCUPS TO TITANIC EXPLOSIONS: Tackling Transients in Anomalous X-ray Pulsars

    NASA Astrophysics Data System (ADS)

    Kaspi, Victoria

    2010-09-01

    The past decade has seen major progress in neutron star astrophysics, with the discovery of magnetars in general, and the recognition that the Anomalous X-ray Pulsars (AXPs) fall in this class. AXPs have recently revealed surprising and dramatic variability behavior, which theorists have begun to show are highly constraining of physical models of magnetars, including their crusts, atmospheres, coronae and magnetospheres. In this proposal, we request Chandra/ACIS-S Target-of-Opportunity observations of one major Anomalous X-ray Pulsar (AXP) outburst in AO12, in order to study in detail the evolution of the spectrum, pulsed fraction and pulse profile, for quantitative confrontation with recently developed models for the structure and electrodynamics of magnetars.

  15. TINY HICCUPS TO TITANIC EXPLOSIONS: Tackling Transients in Anomalous X-ray Pulsars

    NASA Astrophysics Data System (ADS)

    Kaspi, Victoria

    2008-09-01

    The past decade has seen major progress in neutron star astrophysics, with the discovery of magnetars in general, and the recognition that the Anomalous X-ray Pulsars (AXPs) fall in this class. AXPs have recently revealed surprising and dramatic variability behavior, which theorists have begun to show are highly constraining of physical models of magnetars, including their crusts, atmospheres, coronae and magnetospheres. In this proposal, we request Chandra/ACIS-S Target-of-Opportunity observations of one major Anomalous X-ray Pulsar (AXP) outburst in A10, in order to study in detail the evolution of the spectrum, pulsed fraction and pulse profile, for quantitative confrontation with recently developed models for the structure and electrodynamics of magnetars.

  16. TINY HICCUPS TO TITANIC EXPLOSIONS: Tackling Transients in Anomalous X-ray Pulsars

    NASA Astrophysics Data System (ADS)

    Kaspi, Victoria

    2009-09-01

    The past decade has seen major progress in neutron star astrophysics, with the discovery of magnetars in general, and the recognition that the Anomalous X-ray Pulsars (AXPs) fall in this class. AXPs have recently revealed surprising and dramatic variability behavior, which theorists have begun to show are highly constraining of physical models of magnetars, including their crusts, atmospheres, coronae and magnetospheres. In this proposal, we request Chandra/ACIS-S Target-of-Opportunity observations of one major Anomalous X-ray Pulsar (AXP) outburst in A11, in order to study in detail the evolution of the spectrum, pulsed fraction and pulse profile, for quantitative confrontation with recently developed models for the structure and electrodynamics of magnetars.

  17. Tiny Tremors to Titanic Explosions: Tackling Transients in Anomalous X-Ray Pulsars (core Program)

    NASA Astrophysics Data System (ADS)

    We are requesting the target-of-oppurtunity (ToO) component of an ongoing, successful, long-term RXTE monitoring campaign of anomalous X- ray pulsars (AXPs). Their nature had been a mystery, but with our discoveries of X-ray bursts from AXPs, there is compelling evidence that they are young, isolated, ultra-magnetized neutron stars or "magnetars." We request ToO observations of any of the known and candidate AXPs as well as of any newly discovered AXPs should they exhibit anomalous behavior of one or more of the following types: bursts, significant sudden pulse profile changes, glitches or other rotational anomalies, or pulse fractions changes. These observations will allow us to answer basic physical questions about neutron star structure.

  18. Self-crowding of AMPA receptors in the excitatory postsynaptic density can effectuate anomalous receptor sub-diffusion

    PubMed Central

    Gupta, Rahul

    2018-01-01

    AMPA receptors (AMPARs) and their associations with auxiliary transmembrane proteins are bulky structures with large steric-exclusion volumes. Hence, self-crowding of AMPARs, depending on the local density, may affect their lateral diffusion in the postsynaptic membrane as well as in the highly crowded postsynaptic density (PSD) at excitatory synapses. Earlier theoretical studies considered only the roles of transmembrane obstacles and the AMPAR-binding submembranous scaffold proteins in shaping receptor diffusion within PSD. Using lattice model of diffusion, the present study investigates the additional impacts of self-crowding on the anomalousity and effective diffusion coefficient (Deff) of AMPAR diffusion. A recursive algorithm for avoiding false self-blocking during diffusion simulation is also proposed. The findings suggest that high density of AMPARs in the obstacle-free membrane itself engenders strongly anomalous diffusion and severe decline in Deff. Adding transmembrane obstacles to the membrane accentuates the anomalousity arising from self-crowding due to the reduced free diffusion space. Contrarily, enhanced AMPAR-scaffold binding, either through increase in binding strength or scaffold density or both, ameliorates the anomalousity resulting from self-crowding. However, binding has differential impacts on Deff depending on the receptor density. Increase in binding causes consistent decrease in Deff for low and moderate receptor density. For high density, binding increases Deff as long as it reduces anomalousity associated with intense self-crowding. Given a sufficiently strong binding condition when diffusion acquires normal behavior, further increase in binding causes decrease in Deff. Supporting earlier experimental observations are mentioned and implications of present findings to the experimental observations on AMPAR diffusion are also drawn. PMID:29444074

  19. Effects of rogue ryanodine receptors on Ca2+ sparks in cardiac myocytes

    PubMed Central

    Chen, Xudong; Feng, Yundi; Tan, Wenchang

    2018-01-01

    Ca2+ sparks and Ca2+ quarks, arising from clustered and rogue ryanodine receptors (RyRs), are significant Ca2+ release events from the junctional sarcoplasmic reticulum (JSR). Based on the anomalous subdiffusion of Ca2+ in the cytoplasm, a mathematical model was developed to investigate the effects of rogue RyRs on Ca2+ sparks in cardiac myocytes. Ca2+ quarks and sparks from the stochastic opening of rogue and clustered RyRs are numerically reproduced and agree with experimental measurements. It is found that the stochastic opening Ca2+ release units (CRUs) of clustered RyRs are regulated by free Ca2+ concentration in the JSR lumen (i.e. [Ca2+]lumen). The frequency of spontaneous Ca2+ sparks is remarkably increased by the rogue RyRs opening at high [Ca2+]lumen, but not at low [Ca2+]lumen. Hence, the opening of rogue RyRs contributes to the formation of Ca2+ sparks at high [Ca2+]lumen. The interplay of Ca2+ sparks and Ca2+ quarks has been discussed in detail. This work is of significance to provide insight into understanding Ca2+ release mechanisms in cardiac myocytes. PMID:29515864

  20. Effects of rogue ryanodine receptors on Ca2+ sparks in cardiac myocytes.

    PubMed

    Chen, Xudong; Feng, Yundi; Huo, Yunlong; Tan, Wenchang

    2018-02-01

    Ca 2+ sparks and Ca 2+ quarks, arising from clustered and rogue ryanodine receptors (RyRs), are significant Ca 2+ release events from the junctional sarcoplasmic reticulum (JSR). Based on the anomalous subdiffusion of Ca 2+ in the cytoplasm, a mathematical model was developed to investigate the effects of rogue RyRs on Ca 2+ sparks in cardiac myocytes. Ca 2+ quarks and sparks from the stochastic opening of rogue and clustered RyRs are numerically reproduced and agree with experimental measurements. It is found that the stochastic opening Ca 2+ release units (CRUs) of clustered RyRs are regulated by free Ca 2+ concentration in the JSR lumen (i.e. [Ca 2+ ] lumen ). The frequency of spontaneous Ca 2+ sparks is remarkably increased by the rogue RyRs opening at high [Ca 2+ ] lumen , but not at low [Ca 2+ ] lumen . Hence, the opening of rogue RyRs contributes to the formation of Ca 2+ sparks at high [Ca 2+ ] lumen . The interplay of Ca 2+ sparks and Ca 2+ quarks has been discussed in detail. This work is of significance to provide insight into understanding Ca 2+ release mechanisms in cardiac myocytes.

  1. Molecular Dynamics Simulation of Salt Diffusion in Polyelectrolyte Assemblies.

    PubMed

    Zhang, Ran; Duan, Xiaozheng; Ding, Mingming; Shi, Tongfei

    2018-06-05

    The diffusion of salt ions and charged probe molecules in polyelectrolyte assemblies is often assumed to follow a theoretical hopping model, in which the diffusing ion is hopping between charged sites of chains based on electroneutrality. However, experimental verification of diffusing pathway at such microscales is difficult, and the corresponding molecular mechanisms remain elusive. In this study, we perform all-atom molecular dynamics (MD) simulations of salt diffusion in polyelectrolyte (PE) assembly of poly (sodium 4-styrenesulfonate) (PSS) and poly (diallyldimethylammonium chloride) (PDAC). Besides the ion hopping mode, the diffusing trajectories are found presenting common features of a jump process, i.e., subjecting to PE relaxation, water pockets in the structure open and close, thus the ion can move from one pocket to another. Anomalous subdiffusion of ions and water is observed due to the trapping scenarios in these water pockets. The jump events are much rarer compared with ion hopping but significantly increases salt diffusion with increasing temperature. Our result strongly indicates that salt diffusion in hydrated PDAC/PSS is a combined process of ion hopping and jump motion. This provides new molecular explanation for the coupling of salt motion with chain motion and the nonlinear increase of salt diffusion at glass transition temperature.

  2. Brownian motion, old and new, and Irwin's role in my academic life

    NASA Astrophysics Data System (ADS)

    Lindenberg, Katja

    2015-03-01

    Irwin Oppenheim's early work on Langevin equations, master equations, and Brownian motion was one of the earliest and strongest reasons for my change of direction from my PhD work in condensed matter theory to my later and lifelong interest in Brownian motion and, more broadly, statistical mechanics. I will talk about some of my most recent work on subdiffusion, a form of anomalous diffusion that describes random motions in crowded or disordered media where motions are hindered by the medium. On a personal note, I knew Irwin for decades, from the time before he had a family (he was a sworn bachelor...until he met his wife) until shortly before his death. For many years, first alone and then with family, Irwin would spend some portion of the cold Boston winter in warm La Jolla, and we would always get together during these visits. For a period of a number of years we decided to take advantage of these visits to write the definitive text in traditional Thermodynamics. We did not make it past about 2/3 of the project, but it was a great learning experience for me while it lasted. Irwin's knowledge and understanding of the subject were breathtaking.

  3. Transport in the barrier billiard

    NASA Astrophysics Data System (ADS)

    Saberi Fathi, S. M.; Ettoumi, W.; Courbage, M.

    2016-06-01

    We investigate transport properties of an ensemble of particles moving inside an infinite periodic horizontal planar barrier billiard. A particle moves among bars and elastically reflects on them. The motion is a uniform translation along the bars' axis. When the tangent of the incidence angle, α , is fixed and rational, the second moment of the displacement along the orthogonal axis at time n , , is either bounded or asymptotic to K n2 , when n →∞ . For irrational α , the collision map is ergodic and has a family of weakly mixing observables, the transport is not ballistic, and autocorrelation functions decay only in time average, but may not decay for a family of irrational α 's. An exhaustive numerical computation shows that the transport may be superdiffusive or subdiffusive with various rates or bounded strongly depending on the values of α . The variety of transport behaviors sounds reminiscent of well-known behavior of conservative systems. Considering then an ensemble of particles with nonfixed α , the system is nonergodic and certainly not mixing and has anomalous diffusion with self-similar space-time properties. However, we verified that such a system decomposes into ergodic subdynamics breaking self-similarity.

  4. Transport of oxygen ions in Er doped La2Mo2O9 oxide ion conductors: Correlation with microscopic length scales

    NASA Astrophysics Data System (ADS)

    Paul, T.; Ghosh, A.

    2018-01-01

    We report oxygen ion transport in La2-xErxMo2O9 (0.05 ≤ x ≤ 0.25) oxide ion conductors. We have measured conductivity and dielectric spectra at different temperatures in a wide frequency range. The mean square displacement and spatial extent of non-random sub-diffusive regions are estimated from the conductivity spectra and dielectric spectra, respectively, using linear response theory. The composition dependence of the conductivity is observed to be similar to that of the spatial extent of non-random sub-diffusive regions. The behavior of the composition dependence of the mean square displacement of oxygen ions is opposite to that of the conductivity. The attempt frequency estimated from the analysis of the electric modulus agrees well with that obtained from the Raman spectra analysis. The full Rietveld refinement of X-ray diffraction data of the samples is performed to estimate the distance between different oxygen lattice sites. The results obtained from such analysis confirm the ion hopping within the spatial extent of non-random sub-diffusive regions.

  5. Experiments in sensing transient rotational acceleration cues on a flight simulator

    NASA Technical Reports Server (NTRS)

    Parrish, R. V.

    1979-01-01

    Results are presented for two transient motion sensing experiments which were motivated by the identification of an anomalous roll cue (a 'jerk' attributed to an acceleration spike) in a prior investigation of realistic fighter motion simulation. The experimental results suggest the consideration of several issues for motion washout and challenge current sensory system modeling efforts. Although no sensory modeling effort is made it is argued that such models must incorporate the ability to handle transient inputs of short duration (some of which are less than the accepted latency times for sensing), and must represent separate channels for rotational acceleration and velocity sensing.

  6. Nonexponential Decoherence and Momentum Subdiffusion in a Quantum Lévy Kicked Rotator

    NASA Astrophysics Data System (ADS)

    Schomerus, Henning; Lutz, Eric

    2007-06-01

    We investigate decoherence in the quantum kicked rotator (modeling cold atoms in a pulsed optical field) subjected to noise with power-law tail waiting-time distributions of variable exponent (Lévy noise). We demonstrate the existence of a regime of nonexponential decoherence where the notion of a decoherence rate is ill defined. In this regime, dynamical localization is never fully destroyed, indicating that the dynamics of the quantum system never reaches the classical limit. We show that this leads to quantum subdiffusion of the momentum, which should be observable in an experiment.

  7. Robust Satellite Techniques analysis of ten years (2004-2013) of MSG/SEVIRI TIR radiances over Greece region

    NASA Astrophysics Data System (ADS)

    Genzano, N.; Eleftheriou, A.; Filizzola, C.; Paciello, R.; Pergola, N.; Vallianatos, F.; Tramutoli, V.

    2014-12-01

    Space-time fluctuations of Earth's emitted Thermal InfraRed (TIR) radiation have been observed from satellite months to weeks before earthquakes occurrence. Among the different approach proposed to discern transient anomalous signals possibly associated to seismic activity from normal TIR signal fluctuations (i.e. related to the change of natural factor and/or observation conditions), since 2001 the Robust Satellite Techniques (RST) were used to investigate tens of earthquakes with a wide range of magnitudes (from 4.0 to 7.9) occurred in different continents and in various geo-tectonic setting (e.g. Athens earthquake, 7 September 1999; Abruzzo earthquake, 6 April 2009, etc.).The RST approach gives a statistically - based definition of "TIR anomalies" and offers a suitable method for their identification even in very different local (e.g. related to atmosphere and/or surface) and observational (e.g. related to time/season, but also to solar and satellite zenithal angles) conditions. It has been always carried out by using a validation/confutation approach, to verify the presence/absence of anomalous space-time TIR transients in the presence/absence of seismic activity.In this paper, the RST approach is extensively implemented on 10 years of TIR satellite records collected by the geostationary satellite sensor MSG/SEVIRI over the Greece region. The results of the analysis performed to investigate possible correlations (within predefined space-time windows) of anomalous TIR transients with time and place of occurrence of earthquakes with M>4 will be discussed in terms of reliability and effectiveness also in the perspective of a time-Dependent Assessment of Seismic Hazard (t-DASH) system.

  8. Filamentation and light bullet formation dynamics in solid-state dielectric media with weak, moderate and strong anomalous group velocity dispersion

    NASA Astrophysics Data System (ADS)

    Gražulevičiūtė, I.; Garejev, N.; Majus, D.; Jukna, V.; Tamošauskas, G.; Dubietis, A.

    2016-02-01

    We present a series of measurements, which characterize filamentation dynamics of intense ultrashort laser pulses in the space-time domain, as captured by means of three-dimensional imaging technique in sapphire and fused silica, in the wavelength range of 1.45-2.25 μm, accessing the regimes of weak, moderate and strong anomalous group velocity dispersion (GVD). In the regime of weak anomalous GVD (at 1.45 μm), pulse splitting into two sub-pulses producing a pair of light bullets with spectrally shifted carrier frequencies in both nonlinear media is observed. In contrast, in the regimes of moderate (at 1.8 μm) and strong (at 2.25 μm) anomalous GVD we observe notably different transient dynamics, which however lead to the formation of a single self-compressed quasistationary light bullet with an universal spatiotemporal shape comprised of an extended ring-shaped periphery and a localized intense core that carries the self-compressed pulse.

  9. Summary of the CTS Transient Event Counter data after one year of operation. [Communication Technology Satellite

    NASA Technical Reports Server (NTRS)

    Stevens, N. J.; Klinect, V. W.; Gore, J. V.

    1977-01-01

    The environmental charging of satellite surfaces during geomagnetic substorms is the apparent cause of a significant number of anomalous events occurring on geosynchronous satellites since the early 1970's. Electromagnetic pulses produced in connection with the differential charging of insulators can couple into the spacecraft harness and cause electronic switching anomalies. An investigation conducted to determine the response of the spacecraft surfaces to substorm particle fluxes makes use of a harness transient detector. The harness transient detector, called the Transient Event Counter (TEC) was built and integrated into the Canadian-American Communications Technology Satellite (CTS). A description of the TEC and its operational characteristics is given and the obtained data are discussed. The data show that the satellite surfaces appear to be charged to the point that discharges occur and that the discharge-induced transients couple into the wire harnesses.

  10. Predominant nonlinear atmospheric response to meridional shift of the Gulf Stream path from the WRF atmospheric model simulations

    NASA Astrophysics Data System (ADS)

    Seo, H.; Kwon, Y. O.; Joyce, T. M.

    2016-02-01

    A remarkably strong nonlinear behavior of the atmospheric circulation response to North Atlantic SST anomalies (SSTA) is revealed from a set of large-ensemble, high-resolution, and hemispheric-scale Weather Research and Forecasting (WRF) model simulations. The model is forced with the SSTA associated with meridional shift of the Gulf Stream (GS) path, constructed from a lag regression of the winter SST on a GS Index from observation. Analysis of the systematic set of experiments with SSTAs of varied amplitudes and switched signs representing various GS-shift scenarios provides unique insights into mechanism for emergence and evolution of transient and equilibrium response of atmospheric circulation to extratropical SSTA. Results show that, independent of sign of the SSTA, the equilibrium response is characterized by an anomalous trough over the North Atlantic Ocean and the Western Europe concurrent with enhanced storm track, increased rainfall, and reduced blocking days. To the north of the anomalous low, an anomalous ridge emerges over the Greenland, Iceland, and Norwegian Seas accompanied by weakened storm track, reduced rainfall and increased blocking days. This nonlinear component of the total response dominates the weak and oppositely signed linear response that is directly forced by the SSTA, yielding an anomalous ridge (trough) downstream of the warm (cold) SSTA. The amplitude of the linear response is proportional to that of the SSTA, but this is masked by the overwhelmingly strong nonlinear behavior showing no clear correspondence to the SSTA amplitude. The nonlinear pattern emerges 3-4 weeks after the model initialization in November and reaches its first peak amplitude in December/January. It appears that altered baroclinic wave activity due to the GS SSTA in November lead to low-frequency height responses in December/January through transient eddy vorticity flux convergence.

  11. Nonexponential Decoherence and Subdiffusion in Atom-Optics Kicked Rotor.

    PubMed

    Sarkar, Sumit; Paul, Sanku; Vishwakarma, Chetan; Kumar, Sunil; Verma, Gunjan; Sainath, M; Rapol, Umakant D; Santhanam, M S

    2017-04-28

    Quantum systems lose coherence upon interaction with the environment and tend towards classical states. Quantum coherence is known to exponentially decay in time so that macroscopic quantum superpositions are generally unsustainable. In this work, slower than exponential decay of coherences is experimentally realized in an atom-optics kicked rotor system subjected to nonstationary Lévy noise in the applied kick sequence. The slower coherence decay manifests in the form of quantum subdiffusion that can be controlled through the Lévy exponent. The experimental results are in good agreement with the analytical estimates and numerical simulations for the mean energy growth and momentum profiles of an atom-optics kicked rotor.

  12. Molecular dynamics study of nanodroplet diffusion on smooth solid surfaces

    NASA Astrophysics Data System (ADS)

    Niu, Zhao-Xia; Huang, Tao; Chen, Yong

    2018-10-01

    We perform molecular dynamics simulations of Lennard-Jones particles in a canonical ensemble to study the diffusion of nanodroplets on smooth solid surfaces. Using the droplet-surface interaction to realize a hydrophilic or hydrophobic surface and calculating the mean square displacement of the center-of-mass of the nanodroplets, the random motion of nanodroplets could be characterized by shorttime subdiffusion, intermediate-time superdiffusion, and long-time normal diffusion. The short-time subdiffusive exponent increases and almost reaches unity (normal diffusion) with decreasing droplet size or enhancing hydrophobicity. The diffusion coefficient of the droplet on hydrophobic surfaces is larger than that on hydrophilic surfaces.

  13. Mechanisms underlying anomalous diffusion in the plasma membrane.

    PubMed

    Krapf, Diego

    2015-01-01

    The plasma membrane is a complex fluid where lipids and proteins undergo diffusive motion critical to biochemical reactions. Through quantitative imaging analyses such as single-particle tracking, it is observed that diffusion in the cell membrane is usually anomalous in the sense that the mean squared displacement is not linear with time. This chapter describes the different models that are employed to describe anomalous diffusion, paying special attention to the experimental evidence that supports these models in the plasma membrane. We review models based on anticorrelated displacements, such as fractional Brownian motion and obstructed diffusion, and nonstationary models such as continuous time random walks. We also emphasize evidence for the formation of distinct compartments that transiently form on the cell surface. Finally, we overview heterogeneous diffusion processes in the plasma membrane, which have recently attracted considerable interest. Copyright © 2015. Published by Elsevier Inc.

  14. Solvable continuous-time random walk model of the motion of tracer particles through porous media.

    PubMed

    Fouxon, Itzhak; Holzner, Markus

    2016-08-01

    We consider the continuous-time random walk (CTRW) model of tracer motion in porous medium flows based on the experimentally determined distributions of pore velocity and pore size reported by Holzner et al. [M. Holzner et al., Phys. Rev. E 92, 013015 (2015)PLEEE81539-375510.1103/PhysRevE.92.013015]. The particle's passing through one channel is modeled as one step of the walk. The step (channel) length is random and the walker's velocity at consecutive steps of the walk is conserved with finite probability, mimicking that at the turning point there could be no abrupt change of velocity. We provide the Laplace transform of the characteristic function of the walker's position and reductions for different cases of independence of the CTRW's step duration τ, length l, and velocity v. We solve our model with independent l and v. The model incorporates different forms of the tail of the probability density of small velocities that vary with the model parameter α. Depending on that parameter, all types of anomalous diffusion can hold, from super- to subdiffusion. In a finite interval of α, ballistic behavior with logarithmic corrections holds, which was observed in a previously introduced CTRW model with independent l and τ. Universality of tracer diffusion in the porous medium is considered.

  15. The Magnetar Nature and the Outburst Mechanism of a Transient Anomalous X-ray Pulsar

    NASA Technical Reports Server (NTRS)

    Guver, Tolga; Ozel, Feryal; Gogus, Ersin; Kouveliotou, Chryssa

    2007-01-01

    Anomalous X-ray Pulsars (AXPs) belong to a class of neutron stars believed to harbor the strongest magnetic fields in the universe, as indicated by their energetic bursts and their rapid spindowns. However, a direct measurement of their surface field strengths has not been made to date. It is also not known whether AXP outbursts result from changes in the neutron star magnetic field or crust properties. Here we report the first, spectroscopic measurement of the surface magnetic field strength of an AXP, XTE J1810-197, and solidify its magnetar nature. The field strength obtained from detailed spectral analysis and modeling is remarkably close to the value inferred from the rate of spindown of this source and remains nearly constant during numerous observations spanning over two orders of magnitude in source flux. The surface temperature, on the other hand, declines steadily and dramatically following the 2003 outburst of this source. Our findings demonstrate that heating occurs in the upper neutron star crust during an outburst and sheds light on the transient behaviour of AXPs.

  16. Detailed Physical Modeling Reveals the Magnetar Nature of a Transient Anomalous X-ray Pulsar

    NASA Technical Reports Server (NTRS)

    Guever, T.; Oezel, F.; Goegues, E.; Kouveliotou, C.

    2007-01-01

    Anomalous X-ray Pulsars (AXPs) belong to a class of neutron stars believed to harbor the strongest magnetic fields in the universe, as indicated by their energetic bursts and their rapid spindowns. However, a direct measurement of their surface field strengths has not been made to date. It is also not known whether AXP outbursts result from changes in the neutron star magnetic field or crust properties. Here we report the first, spectroscopic measurement of the surface magnetic field strength of an AXP, XTE J1810-197, and solidify its magnetar nature. The field strength obtained from detailed spectral analysis and modeling is remarkably close to the value inferred from the rate of spindown of this source and remains nearly constant during numerous observations spanning over two orders of magnitude in source flux. The surface temperature, on the other hand, declines steadily and dramatically following the 2003 outburst of this source. Our findings demonstrate that heating occurs in the upper neutron star crust during an outburst and sheds light on the transient behaviour of AXPs.

  17. Electrical and Optical Studies of Deep Levels in Nominally Undoped Thallium Bromide

    NASA Astrophysics Data System (ADS)

    Smith, Holland M.; Haegel, Nancy M.; Phillips, David J.; Cirignano, Leonard; Ciampi, Guido; Kim, Hadong; Chrzan, Daryl C.; Haller, Eugene E.

    2014-02-01

    Photo-induced conductivity transient spectroscopy (PICTS) and cathodoluminescence (CL) measurements were performed on nominally undoped detector grade samples of TlBr. In PICTS measurements, nine traps were detected in the temperature range 80-250 K using four-gate analysis. Five of the traps are tentatively identified as electron traps, and four as hole traps. CL measurements yielded two broad peaks common to all samples and most likely associated with defects. Correlations between the optically and electrically detected deep levels are considered. Above 250 K, the photoconductivity transients measured in the PICTS experiments exhibited anomalous transient behavior, indicated by non-monotonic slope variations as a function of time. The origin of the transients is under further investigation, but their presence precludes the accurate determination of trap parameters in TlBr above 250 K with traditional PICTS analysis. Their discovery was made possible by the use of a PICTS system that records whole photoconductivity transients, as opposed to reduced and processed signals.

  18. Preliminary report on the CTS transient event counter performance through the 1976 spring eclipse season

    NASA Technical Reports Server (NTRS)

    Stevens, N. J.; Levell, R. R.; Klinect, V. W.

    1976-01-01

    The transient event counter (TEC), senses and counts transients having a voltage rise of greater than five volts in three separate wire harnesses: the attitude control harness, the solar array instrumentation harness and the solar array power harness. The operational characteristics of TEC are defined and the preliminary results obtained through the first 90 days of operation including the spring 1976 eclipse season are presented. The results show that the Communications Technology Satellite was charged to the point where discharges occurred. The discharge induced transients did not cause any anomalous events in spacecraft operation. The data indicate that discharges can occur at any time during the day without preference to any local time quadrant. The number of discharges occurring in the one second sample interval are greater than anticipated. The compilation and review of the data is continuing.

  19. Sub-diffusion and trapped dynamics of neutral and charged probes in DNA-protein coacervates

    NASA Astrophysics Data System (ADS)

    Arfin, Najmul; Yadav, Avinash Chand; Bohidar, H. B.

    2013-11-01

    The physical mechanism leading to the formation of large intermolecular DNA-protein complexes has been studied. Our study aims to explain the occurrence of fast coacervation dynamics at the charge neutralization point, followed by the appearance of smaller complexes and slower coacervation dynamics as the complex experiences overcharging. Furthermore, the electrostatic potential and probe mobility was investigated to mimic the transport of DNA / DNA-protein complex in a DNA-protein complex coacervate medium [N. Arfin and H. B. Bohidar, J. Phys. Chem. B 116, 13192 (2012)] by assigning neutral, negative, or positive charge to the probe particle. The mobility of the neutral probe was maximal at low matrix concentrations and showed random walk behavior, while its mobility ceased at the jamming concentration of c = 0.6, showing sub-diffusion and trapped dynamics. The positively charged probe showed sub-diffusive random walk followed by trapped dynamics, while the negatively charged probe showed trapping with occasional hopping dynamics at much lower concentrations. Sub-diffusion of the probe was observed in all cases under consideration, where the electrostatic interaction was used exclusively as the dominant force involved in the dynamics. For neutral and positive probes, the mean square displacement ⟨R2⟩ exhibits a scaling with time as ⟨R2⟩ ˜ tα, distinguishing random walk and trapped dynamics at α = 0.64 ± 0.04 at c = 0.12 and c = 0.6, respectively. In addition, the same scaling factors with the exponent β = 0.64 ± 0.04 can be used to distinguish random walk and trapped dynamics for the neutral and positive probes using the relation between the number of distinct sites visited by the probe, S(t), which follows the scaling, S(t) ˜ tβ/ln (t). Our results established the occurrence of a hierarchy of diffusion dynamics experienced by a probe in a dense medium that is either charged or neutral.

  20. Anomalous photoluminescence in InP1−xBix

    PubMed Central

    Wu, Xiaoyan; Chen, Xiren; Pan, Wenwu; Wang, Peng; Zhang, Liyao; Li, Yaoyao; Wang, Hailong; Wang, Kai; Shao, Jun; Wang, Shumin

    2016-01-01

    Low temperature photoluminescence (PL) from InP1−xBix thin films with Bi concentrations in the 0–2.49% range reveals anomalous spectral features with strong and very broad (linewidth of 700 nm) PL signals compared to other bismide alloys. Multiple transitions are observed and their energy levels are found much smaller than the band-gap measured from absorption measurements. These transitions are related to deep levels confirmed by deep level transient spectroscopy, which effectively trap free holes and enhance radiative recombination. The broad luminescence feature is beneficial for making super-luminescence diodes, which can theoretically enhance spatial resolution beyond 1 μm in optical coherent tomography (OCT). PMID:27291823

  1. Modelling and formation of spatiotemporal patterns of fractional predation system in subdiffusion and superdiffusion scenarios

    NASA Astrophysics Data System (ADS)

    Owolabi, Kolade M.; Atangana, Abdon

    2018-02-01

    This paper primarily focused on the question of how population diffusion can affect the formation of the spatial patterns in the spatial fraction predator-prey system by Turing mechanisms. Our numerical findings assert that modeling by fractional reaction-diffusion equations should be considered as an appropriate tool for studying the fundamental mechanisms of complex spatiotemporal dynamics. We observe that pure Hopf instability gives rise to the formation of spiral patterns in 2D and pure Turing instability destroys the spiral pattern and results to the formation of chaotic or spatiotemporal spatial patterns. Existence and permanence of the species is also guaranteed with the 3D simulations at some instances of time for subdiffusive and superdiffusive scenarios.

  2. Self-consistent approach to many-body localization and subdiffusion

    NASA Astrophysics Data System (ADS)

    Prelovšek, P.; Herbrych, J.

    2017-07-01

    An analytical theory, based on the perturbative treatment of the disorder and extended into a self-consistent set of equations for the dynamical density correlations, is developed and applied to the prototype one-dimensional model of many-body localization. Results show a qualitative agreement with the numerically obtained dynamical structure factor in the whole range of frequencies and wave vectors, as well as across the transition to nonergodic behavior. The theory reveals the singular nature of the one-dimensional problem, whereby on the ergodic side the dynamics is subdiffusive with dynamical conductivity σ (ω ) ∝|ω| α , i.e., with vanishing dc limit σ0=0 and α <1 varying with disorder, while we get α >1 in the localized phase.

  3. Normal and Anomalous Diffusion: An Analytical Study Based on Quantum Collision Dynamics and Boltzmann Transport Theory.

    PubMed

    Mahakrishnan, Sathiya; Chakraborty, Subrata; Vijay, Amrendra

    2016-09-15

    Diffusion, an emergent nonequilibrium transport phenomenon, is a nontrivial manifestation of the correlation between the microscopic dynamics of individual molecules and their statistical behavior observed in experiments. We present a thorough investigation of this viewpoint using the mathematical tools of quantum scattering, within the framework of Boltzmann transport theory. In particular, we ask: (a) How and when does a normal diffusive transport become anomalous? (b) What physical attribute of the system is conceptually useful to faithfully rationalize large variations in the coefficient of normal diffusion, observed particularly within the dynamical environment of biological cells? To characterize the diffusive transport, we introduce, analogous to continuous phase transitions, the curvature of the mean square displacement as an order parameter and use the notion of quantum scattering length, which measures the effective interactions between the diffusing molecules and the surrounding, to define a tuning variable, η. We show that the curvature signature conveniently differentiates the normal diffusion regime from the superdiffusion and subdiffusion regimes and the critical point, η = ηc, unambiguously determines the coefficient of normal diffusion. To solve the Boltzmann equation analytically, we use a quantum mechanical expression for the scattering amplitude in the Boltzmann collision term and obtain a general expression for the effective linear collision operator, useful for a variety of transport studies. We also demonstrate that the scattering length is a useful dynamical characteristic to rationalize experimental observations on diffusive transport in complex systems. We assess the numerical accuracy of the present work with representative experimental results on diffusion processes in biological systems. Furthermore, we advance the idea of temperature-dependent effective voltage (of the order of 1 μV or less in a biological environment, for example) as a dynamical cause of the perpetual molecular movement, which eventually manifests as an ordered motion, called the diffusion.

  4. Uncovering homo-and hetero-interactions on the cell membrane using single particle tracking approaches

    NASA Astrophysics Data System (ADS)

    Torreno-Pina, Juan A.; Manzo, Carlo; Garcia-Parajo, Maria F.

    2016-03-01

    The plasma membrane of eukaryotic cells is responsible for a myriad of functions that regulate cell physiology and plays a crucial role in a multitude of processes that include adhesion, migration, signaling recognition and cell-cell communication. This is accomplished by specific interactions between different membrane components such as lipids and proteins on the lipid bilayer but also through interactions with the underlying cortical actin cytoskeleton on the intracellular side and the glycocalyx matrix in close proximity to the extracellular side. Advanced biophysical techniques, including single particle tracking (SPT) have revealed that the lateral diffusion of molecular components on the plasma membrane represents a landmark manifestation of such interactions. Indeed, by studying changes in the diffusivity of individual membrane molecules, including sub-diffusion, confined diffusion and/or transient arrest of molecules in membrane compartments, it has been possible to gain insight on the nature of molecular interactions and to infer on its functional role for cell response. In this review, we will revise some exciting results where SPT has been crucial to reveal homo- and hetero-interactions on the cell membrane.

  5. Crowding and hopping in a protein’s diffusive transport on DNA

    NASA Astrophysics Data System (ADS)

    Koslover, Elena F.; Díaz de la Rosa, Mario; Spakowitz, Andrew J.

    2017-02-01

    Diffusion is a ubiquitous phenomenon that impacts virtually all processes that involve random fluctuations, and as such, the foundational work of Smoluchowski has proven to be instrumental in addressing innumerable problems. Here, we focus on a critical biological problem that relies on diffusive transport and is analyzed using a probabilistic treatment originally developed by Smoluchowski. The search of a DNA binding protein for its specific target site is believed to rely on non-specific binding to DNA with transient hops along the chain. In this work, we address the impact of protein crowding along the DNA on the transport of a DNA-binding protein. The crowders dramatically alter the dynamics of the protein while bound to the DNA, resulting in single-file transport that is subdiffusive in nature. However, transient unbinding and hopping results in a long-time behavior (shown to be superdiffusive) that is qualitatively unaffected by the crowding on the DNA. Thus, hopping along the chain mitigates the role that protein crowding has in restricting the translocation dynamics along the chain. The superdiffusion coefficient is influenced by the quantitative values of the effective binding rate, which is influenced by protein crowding. We show that vacancy fraction and superdiffusion coefficient exhibits a non-monotonic relationship under many circumstances. We leverage analytical theory and dynamic Monte Carlo simulations to address this problem. With several additional contributions, the core of our modeling work adopts a reaction-diffusion framework that is based on Smoluchowski’s original work.

  6. Evidence of Hierarchy in the Complex Fractured System of Geropotamos (Crete, Greece), as Extracted from Transient Electromagnetic Responses

    NASA Astrophysics Data System (ADS)

    Vallianatos, Filippos; Kouli, Maria; Kalisperi, Despina

    2018-03-01

    The essential goals of this paper are to test the transient electromagnetic (TEM) response in a fractured geological complex medium and to better understand the physics introduced by associating a roughness parameter β to the geological formation. An anomalous fractional diffusion approach is incorporated to describe the electromagnetic induction in rough multi-scaled geological structures. The multi-scaling characteristics of Geropotamos basin in Crete are revealed through the analysis of transient step-off response of an EM loop antenna. The semi-empirical parameters derived from late-time TEM measurements are correlated with the multi-scale heterogeneities of the medium. Certain interesting properties of the late-time slope γ(β) and the power law of near surface resistivity distribution, as extracted from TEM inversion for different depth, are presented. The analysis of the parameter γ(β) which scales the induced voltage in the loop in the late stage of the electromagnetic response leads to a different view of the EM geophysical data interpretation. We show that it is strongly correlated with areas of high fracture density within the geological formations of the Geropotamos area. For that reason, it is proposed as a local multi-scaling empirical index. The results of this paper suggest that anomalous diffusion could be a viable physical mechanism for the fractal transport of charge carriers, explaining observed late-time TEM responses across a variety of natural geological settings.

  7. SPECIAL ISSUE DEVOTED TO THE 80TH ANNIVERSARY OF ACADEMICIAN N G BASOV'S BIRTH: Structural rearrangements in the aqueous phase of cell suspensions and protein solutions induced by a light-oxygen effect

    NASA Astrophysics Data System (ADS)

    Zakharov, S. D.; Ivanov, Andrei V.; Wolf, E. B.; Danilov, V. P.; Murina, T. M.; Nguen, K. T.; Novikov, E. G.; Panasenko, N. A.; Perov, S. N.; Skopinov, S. A.; Timofeev, Yu P.

    2003-02-01

    Temperature-dependent transient processes initiated by a direct photogeneration of singlet oxygen in suspensions of human erythrocytes and solutions of serum albumin are studied. The processes appear as anomalous jumps in the temperature dependences of the deformability coefficient of erythrocytes and the refractive index of the extracellular medium and protein solution. In the temperature regions of anomalous jumps, cells and proteins transfer to a metastable state of a lower activity, but they can be isothermally photoreactivated. Simultaneously, a reversible rearrangement of the aqueous phase occurs near the cell and protein surfaces, accompanied by the formation of an extended corona (hydrogel). The transient processes are interpreted as phase transitions in the membrane of erythrocytes and conformation transitions in proteins. The interaction between erythrocytes and albumin via hydrogel is discovered (hydro-conformational interaction). A qualitative physical model of the early stages of the light-oxygen effect is proposed, in which collective magnetic interactions between the electron spins of oxygen molecules and the nuclear magnetic moments of protons in H2O molecules play a dominant role.

  8. Complementary mode analyses between sub- and superdiffusion

    NASA Astrophysics Data System (ADS)

    Saito, Takuya; Sakaue, Takahiro

    2017-04-01

    Several subdiffusive stochastic processes in nature, e.g., the motion of a tagged monomer in polymers, the height fluctuation of interfaces, particle dynamics in single-file diffusion, etc., can be described rigorously or approximately by the superposition of various modes whose relaxation times are broadly distributed. In this paper, we propose a mode analysis generating superdiffusion, which is paired with or complementary to subdiffusion. The key point in our discussion lies in the identification of a pair of conjugated variables, which undergo sub- and superdiffusion, respectively. We provide a simple interpretation for the sub- and superdiffusion duality for these variables using the language of polymer physics. The analysis also suggests the usefulness of looking at the force fluctuation in experiments, where a polymer is driven by a constant velocity.

  9. Nonequilibrium transport of charge carriers and transient electroluminescence in organic light-emitting diodes

    NASA Astrophysics Data System (ADS)

    Nikitenko, V. R.; von Seggern, H.

    2007-11-01

    An analytic theory of nonequilibrium hopping charge transport in disordered organic materials includes quasiequilibrium (normal) and extremely nonequilibrium (dispersive) regimes as limiting cases at long and short times, respectively. In the intermediate interval of time quasiequilibrium value of mobility is nearly established while the coefficient of field-assisted diffusion continues to increase (quasidispersive regime). Therefore, normalized time dependencies of transient current in time-of-flight (TOF) conditions are practically independent of field strength and sample thickness, in good agreement both with data of TOF experiments for molecularly doped polymers and results of numerical simulations of Gaussian disorder model. An analytic model of transient electroluminescence (TEL) is developed on the base of the mentioned theory. Strong asymmetry of mobilities is presumed. In analogy with TOF transients, dispersion parameter of normalized TEL intensity is anomalously large and almost field independent in the quasidispersive regime of transport. The method for determination of mobility from TEL data is proposed.

  10. Membrane Orientation and Lateral Diffusion of BODIPY-Cholesterol as a Function of Probe Structure

    PubMed Central

    Solanko, Lukasz M.; Honigmann, Alf; Midtiby, Henrik Skov; Lund, Frederik W.; Brewer, Jonathan R.; Dekaris, Vjekoslav; Bittman, Robert; Eggeling, Christian; Wüstner, Daniel

    2013-01-01

    Cholesterol tagged with the BODIPY fluorophore via the central difluoroboron moiety of the dye (B-Chol) is a promising probe for studying intracellular cholesterol dynamics. We synthesized a new BODIPY-cholesterol probe (B-P-Chol) with the fluorophore attached via one of its pyrrole rings to carbon-24 of cholesterol (B-P-Chol). Using two-photon fluorescence polarimetry in giant unilamellar vesicles and in the plasma membrane (PM) of living intact and actin-disrupted cells, we show that the BODIPY-groups in B-Chol and B-P-Chol are oriented perpendicular and almost parallel to the bilayer normal, respectively. B-Chol is in all three membrane systems much stronger oriented than B-P-Chol. Interestingly, we found that the lateral diffusion in the PM was two times slower for B-Chol than for B-P-Chol, although we found no difference in lateral diffusion in model membranes. Stimulated emission depletion microscopy, performed for the first time, to our knowledge, with fluorescent sterols, revealed that the difference in lateral diffusion of the BODIPY-cholesterol probes was not caused by anomalous subdiffusion, because diffusion of both analogs in the PM was free but not hindered. Our combined measurements show that the position and orientation of the BODIPY moiety in cholesterol analogs have a severe influence on lateral diffusion specifically in the PM of living cells. PMID:24209853

  11. Linking the South Atlantic Meridional Overturning Circulation and the Global Monsoons

    NASA Astrophysics Data System (ADS)

    Lopez, H.; Dong, S.; Goni, G. J.; Lee, S. K.

    2016-02-01

    This study tested the hypothesis whether low frequency decadal variability of the South Atlantic meridional heat transport (SAMHT) influences decadal variability of the global monsoons. A multi-century run from a state-of-the-art coupled general circulation model is used as basis for the analysis. Our findings indicate that multi-decadal variability of the South Atlantic Ocean plays a key role in modulating atmospheric circulation via interhemispheric changes in Atlantic Ocean heat content. Weaker SAMHT produces anomalous ocean heat divergence over the South Atlantic resulting in negative ocean heat content anomaly about 15 years later. This, in turn, forces a thermally direct anomalous interhemispheric Hadley circulation in the atmosphere, transporting heat from the northern hemisphere (NH) to the southern hemisphere (SH) and moisture from the SH to the NH, thereby intensify (weaken) summer (winter) monsoon in the NH and winter (summer) monsoon in the SH. Results also show that anomalous atmospheric eddies, both transient and stationary, transport heat northward in both hemispheres producing eddy heat flux convergence (divergence) in the NH (SH) around 15-30°, reinforcing the anomalous Hadley circulation. Overall, SAMHT decadal variability leads its atmospheric response by about 15 years, suggesting that the South Atlantic is a potential predictor of global climate variability.

  12. Non-Markovian Model for Transport and Reactions of Particles in Spiny Dendrites

    NASA Astrophysics Data System (ADS)

    Fedotov, Sergei; Méndez, Vicenç

    2008-11-01

    Motivated by the experiments [Santamaria , Neuron 52, 635 (2006)NERNET0896-627310.1016/j.neuron.2006.10.025] that indicated the possibility of subdiffusive transport of molecules along dendrites of cerebellar Purkinje cells, we develop a mesoscopic model for transport and chemical reactions of particles in spiny dendrites. The communication between spines and a parent dendrite is described by a non-Markovian random process and, as a result, the overall movement of particles can be subdiffusive. A system of integrodifferential equations is derived for the particles densities in dendrites and spines. This system involves the spine-dendrite interaction term which describes the memory effects and nonlocality in space. We consider the impact of power-law waiting time distributions on the transport of biochemical signals and mechanism of the accumulation of plasticity-inducing signals inside spines.

  13. Statistical modelling of subdiffusive dynamics in the cytoplasm of living cells: A FARIMA approach

    NASA Astrophysics Data System (ADS)

    Burnecki, K.; Muszkieta, M.; Sikora, G.; Weron, A.

    2012-04-01

    Golding and Cox (Phys. Rev. Lett., 96 (2006) 098102) tracked the motion of individual fluorescently labelled mRNA molecules inside live E. coli cells. They found that in the set of 23 trajectories from 3 different experiments, the automatically recognized motion is subdiffusive and published an intriguing microscopy video. Here, we extract the corresponding time series from this video by image segmentation method and present its detailed statistical analysis. We find that this trajectory was not included in the data set already studied and has different statistical properties. It is best fitted by a fractional autoregressive integrated moving average (FARIMA) process with the normal-inverse Gaussian (NIG) noise and the negative memory. In contrast to earlier studies, this shows that the fractional Brownian motion is not the best model for the dynamics documented in this video.

  14. Optical phantoms with adjustable subdiffusive scattering parameters

    NASA Astrophysics Data System (ADS)

    Krauter, Philipp; Nothelfer, Steffen; Bodenschatz, Nico; Simon, Emanuel; Stocker, Sabrina; Foschum, Florian; Kienle, Alwin

    2015-10-01

    A new epoxy-resin-based optical phantom system with adjustable subdiffusive scattering parameters is presented along with measurements of the intrinsic absorption, scattering, fluorescence, and refractive index of the matrix material. Both an aluminium oxide powder and a titanium dioxide dispersion were used as scattering agents and we present measurements of their scattering and reduced scattering coefficients. A method is theoretically described for a mixture of both scattering agents to obtain continuously adjustable anisotropy values g between 0.65 and 0.9 and values of the phase function parameter γ in the range of 1.4 to 2.2. Furthermore, we show absorption spectra for a set of pigments that can be added to achieve particular absorption characteristics. By additional analysis of the aging, a fully characterized phantom system is obtained with the novelty of g and γ parameter adjustment.

  15. THE SPATIO-TEMPORAL EVOLUTION OF SOLAR FLARES OBSERVED WITH AIA/SDO: FRACTAL DIFFUSION, SUB-DIFFUSION, OR LOGISTIC GROWTH?

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aschwanden, Markus J., E-mail: aschwanden@lmsal.com

    2012-09-20

    We explore the spatio-temporal evolution of solar flares by fitting a radial expansion model r(t) that consists of an exponentially growing acceleration phase, followed by a deceleration phase that is parameterized by the generalized diffusion function r(t){proportional_to}{kappa}(t - t{sub 1}){sup {beta}/2}, which includes the logistic growth limit ({beta} = 0), sub-diffusion ({beta} = 0-1), classical diffusion ({beta} = 1), super-diffusion ({beta} = 1-2), and the linear expansion limit ({beta} = 2). We analyze all M- and X-class flares observed with Geostationary Operational Environmental Satellite and Atmospheric Imaging Assembly/Solar Dynamics Observatory (SDO) during the first two years of the SDO mission,more » amounting to 155 events. We find that most flares operate in the sub-diffusive regime ({beta} = 0.53 {+-} 0.27), which we interpret in terms of anisotropic chain reactions of intermittent magnetic reconnection episodes in a low plasma-{beta} corona. We find a mean propagation speed of v = 15 {+-} 12 km s{sup -1}, with maximum speeds of v{sub max} = 80 {+-} 85 km s{sup -1} per flare, which is substantially slower than the sonic speeds expected for thermal diffusion of flare plasmas. The diffusive characteristics established here (for the first time for solar flares) is consistent with the fractal-diffusive self-organized criticality model, which predicted diffusive transport merely based on cellular automaton simulations.« less

  16. Visualization of exciton transport in ordered and disordered molecular solids.

    PubMed

    Akselrod, Gleb M; Deotare, Parag B; Thompson, Nicholas J; Lee, Jiye; Tisdale, William A; Baldo, Marc A; Menon, Vinod M; Bulović, Vladimir

    2014-04-16

    Transport of nanoscale energy in the form of excitons is at the core of photosynthesis and the operation of a wide range of nanostructured optoelectronic devices such as solar cells, light-emitting diodes and excitonic transistors. Of particular importance is the relationship between exciton transport and nanoscale disorder, the defining characteristic of molecular and nanostructured materials. Here we report a spatial, temporal and spectral visualization of exciton transport in molecular crystals and disordered thin films. Using tetracene as an archetype molecular crystal, the imaging reveals that exciton transport occurs by random walk diffusion, with a transition to subdiffusion as excitons become trapped. By controlling the morphology of the thin film, we show that this transition to subdiffusive transport occurs at earlier times as disorder is increased. Our findings demonstrate that the mechanism of exciton transport depends strongly on the nanoscale morphology, which has wide implications for the design of excitonic materials and devices.

  17. Crowding Effects in Vehicular Traffic

    PubMed Central

    Combinido, Jay Samuel L.; Lim, May T.

    2012-01-01

    While the impact of crowding on the diffusive transport of molecules within a cell is widely studied in biology, it has thus far been neglected in traffic systems where bulk behavior is the main concern. Here, we study the effects of crowding due to car density and driving fluctuations on the transport of vehicles. Using a microscopic model for traffic, we found that crowding can push car movement from a superballistic down to a subdiffusive state. The transition is also associated with a change in the shape of the probability distribution of positions from a negatively-skewed normal to an exponential distribution. Moreover, crowding broadens the distribution of cars’ trap times and cluster sizes. At steady state, the subdiffusive state persists only when there is a large variability in car speeds. We further relate our work to prior findings from random walk models of transport in cellular systems. PMID:23139762

  18. Crossover from Super- to Subdiffusive Motion and Memory Effects in Crystalline Organic Semiconductors

    NASA Astrophysics Data System (ADS)

    De Filippis, G.; Cataudella, V.; Mishchenko, A. S.; Nagaosa, N.; Fierro, A.; de Candia, A.

    2015-02-01

    The transport properties at finite temperature of crystalline organic semiconductors are investigated, within the Su-Schrieffer-Heeger model, by combining an exact diagonalization technique, Monte Carlo approaches, and a maximum entropy method. The temperature-dependent mobility data measured in single crystals of rubrene are successfully reproduced: a crossover from super- to subdiffusive motion occurs in the range 150 ≤T ≤200 K , where the mean free path becomes of the order of the lattice parameter and strong memory effects start to appear. We provide an effective model, which can successfully explain features of the absorption spectra at low frequencies. The observed response to slowly varying electric field is interpreted by means of a simple model where the interaction between the charge carrier and lattice polarization modes is simulated by a harmonic interaction between a fictitious particle and an electron embedded in a viscous fluid.

  19. Crossover from super- to subdiffusive motion and memory effects in crystalline organic semiconductors.

    PubMed

    De Filippis, G; Cataudella, V; Mishchenko, A S; Nagaosa, N; Fierro, A; de Candia, A

    2015-02-27

    The transport properties at finite temperature of crystalline organic semiconductors are investigated, within the Su-Schrieffer-Heeger model, by combining an exact diagonalization technique, Monte Carlo approaches, and a maximum entropy method. The temperature-dependent mobility data measured in single crystals of rubrene are successfully reproduced: a crossover from super- to subdiffusive motion occurs in the range 150≤T≤200  K, where the mean free path becomes of the order of the lattice parameter and strong memory effects start to appear. We provide an effective model, which can successfully explain features of the absorption spectra at low frequencies. The observed response to slowly varying electric field is interpreted by means of a simple model where the interaction between the charge carrier and lattice polarization modes is simulated by a harmonic interaction between a fictitious particle and an electron embedded in a viscous fluid.

  20. Noteworthy fractal features and transport properties of Cantor tartans

    NASA Astrophysics Data System (ADS)

    Balankin, Alexander S.; Golmankhaneh, Alireza K.; Patiño-Ortiz, Julián; Patiño-Ortiz, Miguel

    2018-06-01

    This Letter is focused on the impact of fractal topology on the transport processes governed by different kinds of random walks on Cantor tartans. We establish that the spectral dimension of the infinitely ramified Cantor tartan ds is equal to its fractal (self-similarity) dimension D. Consequently, the random walk on the Cantor tartan leads to a normal diffusion. On the other hand, the fractal geometry of Cantor tartans allows for a natural definition of power-law distributions of the waiting times and step lengths of random walkers. These distributions are Lévy stable if D > 1.5. Accordingly, we found that the random walk with rests leads to sub-diffusion, whereas the Lévy walk leads to ballistic diffusion. The Lévy walk with rests leads to super-diffusion, if D >√{ 3 }, or sub-diffusion, if 1.5 < D <√{ 3 }.

  1. From stochastic processes to numerical methods: A new scheme for solving reaction subdiffusion fractional partial differential equations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Angstmann, C.N.; Donnelly, I.C.; Henry, B.I., E-mail: B.Henry@unsw.edu.au

    We have introduced a new explicit numerical method, based on a discrete stochastic process, for solving a class of fractional partial differential equations that model reaction subdiffusion. The scheme is derived from the master equations for the evolution of the probability density of a sum of discrete time random walks. We show that the diffusion limit of the master equations recovers the fractional partial differential equation of interest. This limiting procedure guarantees the consistency of the numerical scheme. The positivity of the solution and stability results are simply obtained, provided that the underlying process is well posed. We also showmore » that the method can be applied to standard reaction–diffusion equations. This work highlights the broader applicability of using discrete stochastic processes to provide numerical schemes for partial differential equations, including fractional partial differential equations.« less

  2. Tracer diffusion in a sea of polymers with binding zones: mobile vs. frozen traps.

    PubMed

    Samanta, Nairhita; Chakrabarti, Rajarshi

    2016-10-19

    We use molecular dynamics simulations to investigate the tracer diffusion in a sea of polymers with specific binding zones for the tracer. These binding zones act as traps. Our simulations show that the tracer can undergo normal yet non-Gaussian diffusion under certain circumstances, e.g., when the polymers with traps are frozen in space and the volume fraction and the binding strength of the traps are moderate. In this case, as the tracer moves, it experiences a heterogeneous environment and exhibits confined continuous time random walk (CTRW) like motion resulting in a non-Gaussian behavior. Also the long time dynamics becomes subdiffusive as the number or the binding strength of the traps increases. However, if the polymers are mobile then the tracer dynamics is Gaussian but could be normal or subdiffusive depending on the number and the binding strength of the traps. In addition, with increasing binding strength and number of polymer traps, the probability of the tracer being trapped increases. On the other hand, removing the binding zones does not result in trapping, even at comparatively high crowding. Our simulations also show that the trapping probability increases with the increasing size of the tracer and for a bigger tracer with the frozen polymer background the dynamics is only weakly non-Gaussian but highly subdiffusive. Our observations are in the same spirit as found in many recent experiments on tracer diffusion in polymeric materials and question the validity of using Gaussian theory to describe diffusion in a crowded environment in general.

  3. Remedial Investigation Badger Army Ammunition Plant, Baraboo, Wisconsin. Volume 1. Appendices A Through D

    DTIC Science & Technology

    1991-01-01

    patterns and water circulations, normal water fluctuations, salinity, threatened and endangered species, fish or other aquatic organisms in the food web ...velocity and anchoring of sediments; * habitat for aquatic organisms in the food web ; 0 habitat for resident and transient wildlife species; and...The remaining anomalous areas, RA-2 and RA-5 (3 to 5 + feet deep ), coincide with the location of former possible landfilling activities. However, it

  4. Connecting complexity with spectral entropy using the Laplace transformed solution to the fractional diffusion equation

    NASA Astrophysics Data System (ADS)

    Liang, Yingjie; Chen, Wen; Magin, Richard L.

    2016-07-01

    Analytical solutions to the fractional diffusion equation are often obtained by using Laplace and Fourier transforms, which conveniently encode the order of the time and the space derivatives (α and β) as non-integer powers of the conjugate transform variables (s, and k) for the spectral and the spatial frequencies, respectively. This study presents a new solution to the fractional diffusion equation obtained using the Laplace transform and expressed as a Fox's H-function. This result clearly illustrates the kinetics of the underlying stochastic process in terms of the Laplace spectral frequency and entropy. The spectral entropy is numerically calculated by using the direct integration method and the adaptive Gauss-Kronrod quadrature algorithm. Here, the properties of spectral entropy are investigated for the cases of sub-diffusion and super-diffusion. We find that the overall spectral entropy decreases with the increasing α and β, and that the normal or Gaussian case with α = 1 and β = 2, has the lowest spectral entropy (i.e., less information is needed to describe the state of a Gaussian process). In addition, as the neighborhood over which the entropy is calculated increases, the spectral entropy decreases, which implies a spatial averaging or coarse graining of the material properties. Consequently, the spectral entropy is shown to provide a new way to characterize the temporal correlation of anomalous diffusion. Future studies should be designed to examine changes of spectral entropy in physical, chemical and biological systems undergoing phase changes, chemical reactions and tissue regeneration.

  5. Anomalous yet Brownian.

    PubMed

    Wang, Bo; Anthony, Stephen M; Bae, Sung Chul; Granick, Steve

    2009-09-08

    We describe experiments using single-particle tracking in which mean-square displacement is simply proportional to time (Fickian), yet the distribution of displacement probability is not Gaussian as should be expected of a classical random walk but, instead, is decidedly exponential for large displacements, the decay length of the exponential being proportional to the square root of time. The first example is when colloidal beads diffuse along linear phospholipid bilayer tubes whose radius is the same as that of the beads. The second is when beads diffuse through entangled F-actin networks, bead radius being less than one-fifth of the actin network mesh size. We explore the relevance to dynamic heterogeneity in trajectory space, which has been extensively discussed regarding glassy systems. Data for the second system might suggest activated diffusion between pores in the entangled F-actin networks, in the same spirit as activated diffusion and exponential tails observed in glassy systems. But the first system shows exceptionally rapid diffusion, nearly as rapid as for identical colloids in free suspension, yet still displaying an exponential probability distribution as in the second system. Thus, although the exponential tail is reminiscent of glassy systems, in fact, these dynamics are exceptionally rapid. We also compare with particle trajectories that are at first subdiffusive but Fickian at the longest measurement times, finding that displacement probability distributions fall onto the same master curve in both regimes. The need is emphasized for experiments, theory, and computer simulation to allow definitive interpretation of this simple and clean exponential probability distribution.

  6. Membrane orientation and lateral diffusion of BODIPY-cholesterol as a function of probe structure.

    PubMed

    Solanko, Lukasz M; Honigmann, Alf; Midtiby, Henrik Skov; Lund, Frederik W; Brewer, Jonathan R; Dekaris, Vjekoslav; Bittman, Robert; Eggeling, Christian; Wüstner, Daniel

    2013-11-05

    Cholesterol tagged with the BODIPY fluorophore via the central difluoroboron moiety of the dye (B-Chol) is a promising probe for studying intracellular cholesterol dynamics. We synthesized a new BODIPY-cholesterol probe (B-P-Chol) with the fluorophore attached via one of its pyrrole rings to carbon-24 of cholesterol (B-P-Chol). Using two-photon fluorescence polarimetry in giant unilamellar vesicles and in the plasma membrane (PM) of living intact and actin-disrupted cells, we show that the BODIPY-groups in B-Chol and B-P-Chol are oriented perpendicular and almost parallel to the bilayer normal, respectively. B-Chol is in all three membrane systems much stronger oriented than B-P-Chol. Interestingly, we found that the lateral diffusion in the PM was two times slower for B-Chol than for B-P-Chol, although we found no difference in lateral diffusion in model membranes. Stimulated emission depletion microscopy, performed for the first time, to our knowledge, with fluorescent sterols, revealed that the difference in lateral diffusion of the BODIPY-cholesterol probes was not caused by anomalous subdiffusion, because diffusion of both analogs in the PM was free but not hindered. Our combined measurements show that the position and orientation of the BODIPY moiety in cholesterol analogs have a severe influence on lateral diffusion specifically in the PM of living cells. Copyright © 2013 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  7. The link between Tibetan Plateau monsoon and Indian summer precipitation: a linear diagnostic perspective

    NASA Astrophysics Data System (ADS)

    Ge, Fei; Sielmann, Frank; Zhu, Xiuhua; Fraedrich, Klaus; Zhi, Xiefei; Peng, Ting; Wang, Lei

    2017-12-01

    The thermal forcing of the Tibetan Plateau (TP) is analyzed to investigate the formation and variability of Tibetan Plateau Summer Monsoon (TPSM), which affects the climates of the surrounding regions, in particular the Indian summer monsoon precipitation. Dynamic composites and statistical analyses indicate that the Indian summer monsoon precipitation is less/greater than normal during the strong/weak TPSM. Strong (weak) TPSM is associated with an anomalous near surface cyclone (anticyclone) over the western part of the Tibetan Plateau, enhancing (reducing) the westerly flow along its southern flank, suppressing (favoring) the meridional flow of warm and moist air from the Indian ocean and thus cutting (providing) moisture supply for the northern part of India and its monsoonal rainfall. These results are complemented by a dynamic and thermodynamic analysis: (i) A linear thermal vorticity forcing primarily describes the influence of the asymmetric heating of TP generating an anomalous stationary wave flux. Composite analysis of anomalous stationary wave flux activity (after Plumb in J Atmos Sci 42:217-229, 1985) strongly indicate that non-orographic effects (diabatic heating and/or interaction with transient eddies) of the Tibetan Plateau contribute to the generation of an anomalous cyclone (anti-cyclone) over the western TP. (ii) Anomalous TPSM generation shows that strong TPSM years are related to the positive surface sensible heating anomalies over the eastern TP favoring the strong diabatic heating in summer. While negative TPSM years are associated with the atmospheric circulation anomalies during the preceding spring, enhancing northerly dry-cold air intrusions into TP, which may weaken the condensational heat release in the middle and upper troposphere, leading to a weaker than normal summer monsoon over the TP in summer.

  8. Anomalous K-Pg-aged seafloor attributed to impact-induced mid-ocean ridge magmatism.

    PubMed

    Byrnes, Joseph S; Karlstrom, Leif

    2018-02-01

    Eruptive phenomena at all scales, from hydrothermal geysers to flood basalts, can potentially be initiated or modulated by external mechanical perturbations. We present evidence for the triggering of magmatism on a global scale by the Chicxulub meteorite impact at the Cretaceous-Paleogene (K-Pg) boundary, recorded by transiently increased crustal production at mid-ocean ridges. Concentrated positive free-air gravity and coincident seafloor topographic anomalies, associated with seafloor created at fast-spreading rates, suggest volumes of excess magmatism in the range of ~10 5 to 10 6 km 3 . Widespread mobilization of existing mantle melt by post-impact seismic radiation can explain the volume and distribution of the anomalous crust. This massive but short-lived pulse of marine magmatism should be considered alongside the Chicxulub impact and Deccan Traps as a contributor to geochemical anomalies and environmental changes at K-Pg time.

  9. Anomalous K-Pg–aged seafloor attributed to impact-induced mid-ocean ridge magmatism

    PubMed Central

    Byrnes, Joseph S.; Karlstrom, Leif

    2018-01-01

    Eruptive phenomena at all scales, from hydrothermal geysers to flood basalts, can potentially be initiated or modulated by external mechanical perturbations. We present evidence for the triggering of magmatism on a global scale by the Chicxulub meteorite impact at the Cretaceous-Paleogene (K-Pg) boundary, recorded by transiently increased crustal production at mid-ocean ridges. Concentrated positive free-air gravity and coincident seafloor topographic anomalies, associated with seafloor created at fast-spreading rates, suggest volumes of excess magmatism in the range of ~105 to 106 km3. Widespread mobilization of existing mantle melt by post-impact seismic radiation can explain the volume and distribution of the anomalous crust. This massive but short-lived pulse of marine magmatism should be considered alongside the Chicxulub impact and Deccan Traps as a contributor to geochemical anomalies and environmental changes at K-Pg time. PMID:29441360

  10. Investigating anomalous transport of electrolytes in charged porous media

    NASA Astrophysics Data System (ADS)

    Skjøde Bolet, Asger Johannes; Mathiesen, Joachim

    2017-04-01

    Surface charge is know to play an important role in microfluidics devices when dealing with electrolytes and their transport properties. Similarly, surface charge could play a role for transport in porous rock with submicron pore sizes. Estimates of the streaming potentials and electro osmotic are mostly considered in simple geometries both using analytic and numerical tools, however it is unclear at present how realistic complex geometries will modify the dynamics. Our work have focused on doing numerical studies of the full three-dimensional Stokes-Poisson-Nernst-Planck problem for electrolyte transport in porous rock. As the numerical implementation, we have used a finite element solver made using the FEniCS project code base, which can both solve for a steady state configuration and the full transient. In the presentation, we will show our results on anomalous transport due to electro kinetic effects such as the streaming potential or the electro osmotic effect.

  11. Asymptotic properties of a bold random walk

    NASA Astrophysics Data System (ADS)

    Serva, Maurizio

    2014-08-01

    In a recent paper we proposed a non-Markovian random walk model with memory of the maximum distance ever reached from the starting point (home). The behavior of the walker is different from the simple symmetric random walk only when she is at this maximum distance, where, having the choice to move either farther or closer, she decides with different probabilities. If the probability of a forward step is higher than the probability of a backward step, the walker is bold and her behavior turns out to be superdiffusive; otherwise she is timorous and her behavior turns out to be subdiffusive. The scaling behavior varies continuously from subdiffusive (timorous) to superdiffusive (bold) according to a single parameter γ ∈R. We investigate here the asymptotic properties of the bold case in the nonballistic region γ ∈[0,1/2], a problem which was left partially unsolved previously. The exact results proved in this paper require new probabilistic tools which rely on the construction of appropriate martingales of the random walk and its hitting times.

  12. Intracellular microrheology of motile Amoeba proteus.

    PubMed

    Rogers, Salman S; Waigh, Thomas A; Lu, Jian R

    2008-04-15

    The motility of Amoeba proteus was examined using the technique of passive particle tracking microrheology, with the aid of newly developed particle tracking software, a fast digital camera, and an optical microscope. We tracked large numbers of endogeneous particles in the amoebae, which displayed subdiffusive motion at short timescales, corresponding to thermal motion in a viscoelastic medium, and superdiffusive motion at long timescales due to the convection of the cytoplasm. Subdiffusive motion was characterized by a rheological scaling exponent of 3/4 in the cortex, indicative of the semiflexible dynamics of the actin fibers. We observed shear-thinning in the flowing endoplasm, where exponents increased with increasing flow rate; i.e., the endoplasm became more fluid-like. The rheology of the cortex is found to be isotropic, reflecting an isotropic actin gel. A clear difference was seen between cortical and endoplasmic layers in terms of both viscoelasticity and flow velocity, where the profile of the latter is close to a Poiseuille flow for a Newtonian fluid.

  13. Intracellular Microrheology of Motile Amoeba proteus

    PubMed Central

    Rogers, Salman S.; Waigh, Thomas A.; Lu, Jian R.

    2008-01-01

    The motility of Amoeba proteus was examined using the technique of passive particle tracking microrheology, with the aid of newly developed particle tracking software, a fast digital camera, and an optical microscope. We tracked large numbers of endogeneous particles in the amoebae, which displayed subdiffusive motion at short timescales, corresponding to thermal motion in a viscoelastic medium, and superdiffusive motion at long timescales due to the convection of the cytoplasm. Subdiffusive motion was characterized by a rheological scaling exponent of 3/4 in the cortex, indicative of the semiflexible dynamics of the actin fibers. We observed shear-thinning in the flowing endoplasm, where exponents increased with increasing flow rate; i.e., the endoplasm became more fluid-like. The rheology of the cortex is found to be isotropic, reflecting an isotropic actin gel. A clear difference was seen between cortical and endoplasmic layers in terms of both viscoelasticity and flow velocity, where the profile of the latter is close to a Poiseuille flow for a Newtonian fluid. PMID:18192370

  14. Intracellular Microrheology of Motile Amoeba proteus

    NASA Astrophysics Data System (ADS)

    Rogers, S.; Waigh, T.; Lu, J.

    2008-04-01

    The motility of motile Amoeba proteus was examined using the technique of passive particle tracking microrheology, with the aid of newly-developed particle tracking software, a fast digital camera and an optical microscope. We tracked large numbers of endogeneous particles in the amoebae, which displayed subdiffusive motion at short time scales, corresponding to thermal motion in a viscoelastic medium, and superdiffusive motion at long time scales due to the convection of the cytoplasm. Subdiffusive motion was characterised by a rheological scaling exponent of 3/4 in the cortex, indicative of the semiflexible dynamics of the actin fibres. We observed shear-thinning in the flowing endoplasm, where exponents increased with increasing flow rate; i.e. the endoplasm became more fluid-like. The rheology of the cortex is found to be isotropic, reflecting an isotropic actin gel. A clear difference was seen between cortical and endoplasmic layers in terms of both viscoelasticity and flow velocity, where the profile of the latter is close to a Poiseuille flow for a Newtonian fluid.

  15. Weather chains during the 2013/2014 winter and their significance for seasonal prediction

    NASA Astrophysics Data System (ADS)

    Davies, Huw C.

    2015-11-01

    Day-to-day weather forecasting has improved substantially over the past few decades. In contrast, progress in seasonal prediction outside the tropics has been meagre and mixed. On seasonal timescales, the constraining influence of the initial atmospheric state is weak, and the internal variability associated with transient weather systems tends to be large compared with the nuanced influence of anomalies in external forcing. Current research and operational activities focus on exploring and exploiting potential links between external anomalies and seasonal-mean climate patterns. Here I examine reanalysed meteorological data sets for the unusual winter 2013/2014, with drought and freezing conditions juxtaposed over North America and severe wet and stormy weather over parts of Europe, to study the role of weather systems and their transient upper-tropospheric flow patterns. I find that the amplitude, recurrence and location of these transient patterns account directly for the corresponding anomalous seasonal-mean patterns. They occurred episodically and sequentially, were linked dynamically, and exhibited some circumpolar connectivity. I conclude that the upper-tropospheric components of transient weather systems are significant for understanding and predicting seasonal weather patterns, whereas the role of external factors is more subtle.

  16. On The Constitutive Properties Of Strongly Magnetized Matter Observed In A Class Of Solar Ejecta

    NASA Astrophysics Data System (ADS)

    Berdichevsky, D. B.

    2013-12-01

    Several studies of the transient events known as magnetic clouds at 1 AU suggest that they possess the ';1/2' anomalous value for its adiabatic, polytropic index, i.e., γ= 1/2, which implies that the temperature of the plasma decreases with increased density[1-3]. Coronal mass ejections commonly observed by missions like The Solar Terrestrial Relations Observatory (STEREO) have been successfully modeled previously by Berdichevsky Stenborg and Vourlidas[4] as magnetic flux-ropes which propagate from the Sun with uniform velocity. Building on this existing analytical three-dimensional magnetohydrodynamic (MHD) model of a magnetic flux-rope, we present an interpretation of the anomalous and somewhat counterintuitive dynamic property mentioned above. Using plasma and magnetic field observations by the Wind spacecraft for the magnetic cloud of June 2, 1998, we argue that this anomalous polytropic index is indeed a consequence of thermodynamic processes in this strongly magnetized matter. We show that the derived models of Berdichevsky et al.[5, 6] easily accommodate a familiar thermodynamic explanation of this property. Such an explanation may shed light also on the evolution of other astrophysical observations such as remnants in nebulae of past super-novae, as well other transient interstellar events. This MHD solution may be a good way to go beyond gas-dynamics in the development of a coherent picture of shock and its driver, as they are becoming a current interpretation. 1Osherovich, V.A., 1997, Proc. 31st, ESLAB Symp. Correlated Phenomena at the Sun, in the Heliosphere and in Geospace. 2Sittler, E.C., and L.F., Burlaga, 1998, J. Geophys. Res., 103, 17447. 3Nieves-Chinchilla T., and A., Figueroa-Viñas, 2008, J. Geophys. Res., 113, DOI: 10.1029/2007JA012703 4Berdichevsky, Stenborg, and Vourlidas, 2011, ApJ, 741, 47. 5Berdichevsky, D.B., R.L., Lepping, C.J., Farrugia, 2003, Phys.Rev. E, 67, DOI: 10.1103/PhysRevE036405. 6Berdichevsky, D.B. , 2012, Sol. Phys., 284, 245.

  17. Numerical analysis of multicomponent responses of surface-hole transient electromagnetic method

    NASA Astrophysics Data System (ADS)

    Meng, Qing-Xin; Hu, Xiang-Yun; Pan, He-Ping; Zhou, Feng

    2017-03-01

    We calculate the multicomponent responses of surface-hole transient electromagnetic method. The methods and models are unsuitable as geoelectric models of conductive surrounding rocks because they are based on regular local targets. We also propose a calculation and analysis scheme based on numerical simulations of the subsurface transient electromagnetic fields. In the modeling of the electromagnetic fields, the forward modeling simulations are performed by using the finite-difference time-domain method and the discrete image method, which combines the Gaver-Stehfest inverse Laplace transform with the Prony method to solve the initial electromagnetic fields. The precision in the iterative computations is ensured by using the transmission boundary conditions. For the response analysis, we customize geoelectric models consisting of near-borehole targets and conductive wall rocks and implement forward modeling simulations. The observed electric fields are converted into induced electromotive force responses using multicomponent observation devices. By comparing the transient electric fields and multicomponent responses under different conditions, we suggest that the multicomponent-induced electromotive force responses are related to the horizontal and vertical gradient variations of the transient electric field at different times. The characteristics of the response are determined by the varying the subsurface transient electromagnetic fields, i.e., diffusion, attenuation and distortion, under different conditions as well as the electromagnetic fields at the observation positions. The calculation and analysis scheme of the response consider the surrounding rocks and the anomalous field of the local targets. It therefore can account for the geological data better than conventional transient field response analysis of local targets.

  18. Fractional Brownian motion run with a multi-scaling clock mimics diffusion of spherical colloids in microstructural fluids.

    PubMed

    Park, Moongyu; Cushman, John Howard; O'Malley, Dan

    2014-09-30

    The collective molecular reorientations within a nematic liquid crystal fluid bathing a spherical colloid cause the colloid to diffuse anomalously on a short time scale (i.e., as a non-Brownian particle). The deformations and fluctuations of long-range orientational order in the liquid crystal profoundly influence the transient diffusive regimes. Here we show that an anisotropic fractional Brownian process run with a nonlinear multiscaling clock effectively mimics this collective and transient phenomenon. This novel process has memory, Gaussian increments, and a multiscale mean square displacement that can be chosen independently from the fractal dimension of a particle trajectory. The process is capable of modeling multiscale sub-, super-, or classical diffusion. The finite-size Lyapunov exponents for this multiscaling process are defined for future analysis of related mixing processes.

  19. Surgical repair and postoperative course of an infant with infracardiac total anomalous pulmonary venous connection, cor triatriatum sinistrum and transposition of the great arteries.

    PubMed

    Thies, W R; Matthies, W; Minami, K; Pott, U; Meyer, H; Körfer, R

    1990-01-01

    The combination of a d-transposition of the great arteries, cor triatriatum sinistrum and a total anomalous pulmonary venous connection of the infracardiac type is a very rare condition. Up to now, one surgical repair in an adolescent with transposed great arteries and total anomalous pulmonary venous drainage of the supracardiac type has been reported. In this paper, an infant with the above mentioned cardiovascular malformation is presented. The common pulmonary vein drained into the inferior vena cava and was obstructed. There were arborisation abnormalities in both lungs with mild pulmonary hypertension. The infant has been successfully operated upon at the age of 6 months and a weight of 4.5 kg. The membrane within the left atrium was resected, the common pulmonary vein was anastomosed to the left atrium and a Mustard procedure was performed. During the first 6 postoperative weeks, the infant had problems with adaptation. There was both a transient ballooning of the Mustard patch with significant obstruction of the pulmonary venous drainage and a delayed pulmonary recovery. Two months later, the patch was straightened and the child could be discharged from hospital. After 12 months, the child died from an infection of the airways.

  20. Interannual-to-decadal air-sea interactions in the tropical Atlantic region

    NASA Astrophysics Data System (ADS)

    Ruiz-Barradas, Alfredo

    2001-09-01

    The present research identifies modes of atmosphere-ocean interaction in the tropical Atlantic region and the mechanisms by which air-sea interactions influence the regional climate. Novelties of the present work are (1)the use of relevant ocean and atmosphere variables important to identity coupled variability in the system. (2)The use of new data sets, including realistic diabatic heating. (3)The study of interactions between ocean and atmosphere relevant at interannual-to-decadal time scales. Two tropical modes of variability are identified during the period 1958-1993, the Atlantic Niño mode and the Interhemispheric mode. Those modes have defined structures in both ocean and atmosphere. Anomalous sea surface temperatures and winds are associated to anomalous placement of the Intertropical Convergence Zone (ITCZ). They develop maximum amplitude during boreal summer and spring, respectively. The anomalous positioning of the ITCZ produces anomalous precipitation in some places like Nordeste, Brazil and the Caribbean region. Through the use of a diagnostic primitive equation model, it is found that the most important terms controlling local anomalous surface winds over the ocean are boundary layer temperature gradients and diabatic heating anomalies at low levels (below 780 mb). The latter is of particular importance in the deep tropics in producing the anomalous meridional response to the surface circulation. Simulated latent heat anomalies indicate that a thermodynamic feedback establishes positive feedbacks at both sides of the equator and west of 20°W in the deep tropics and a negative feedback in front of the north west coast of Africa for the Interhemispheric mode. This thermodynamic feedback only establishes negative feedbacks for the Atlantic Niño mode. Transients establish some connection between the tropical Atlantic and other basins. Interhemispheric gradients of surface temperature in the tropical Atlantic influence winds in the midlatitude North Atlantic but winds and heating of the midlatitude North Atlantic have little impact on the deep tropics. The remote influence of El Niño-Southern Oscillation in the tropical Atlantic, similar to the Interhemispheric mode, is the result of two mechanisms triggered by anomalous warming in the central and eastern tropical Pacific: enhancement of the Atlantic Walker circulation, and coupled intrusion of negative 200 mb geopotential height anomalies and negative sea level pressure anomalies that induce southwesterly surface wind anomalies in the northern tropical Atlantic.

  1. Non-Brownian diffusion in lipid membranes: Experiments and simulations.

    PubMed

    Metzler, R; Jeon, J-H; Cherstvy, A G

    2016-10-01

    The dynamics of constituents and the surface response of cellular membranes-also in connection to the binding of various particles and macromolecules to the membrane-are still a matter of controversy in the membrane biophysics community, particularly with respect to crowded membranes of living biological cells. We here put into perspective recent single particle tracking experiments in the plasma membranes of living cells and supercomputing studies of lipid bilayer model membranes with and without protein crowding. Special emphasis is put on the observation of anomalous, non-Brownian diffusion of both lipid molecules and proteins embedded in the lipid bilayer. While single component, pure lipid bilayers in simulations exhibit only transient anomalous diffusion of lipid molecules on nanosecond time scales, the persistence of anomalous diffusion becomes significantly longer ranged on the addition of disorder-through the addition of cholesterol or proteins-and on passing of the membrane lipids to the gel phase. Concurrently, experiments demonstrate the anomalous diffusion of membrane embedded proteins up to macroscopic time scales in the minute time range. Particular emphasis will be put on the physical character of the anomalous diffusion, in particular, the occurrence of ageing observed in the experiments-the effective diffusivity of the measured particles is a decreasing function of time. Moreover, we present results for the time dependent local scaling exponent of the mean squared displacement of the monitored particles. Recent results finding deviations from the commonly assumed Gaussian diffusion patterns in protein crowded membranes are reported. The properties of the displacement autocorrelation function of the lipid molecules are discussed in the light of their appropriate physical anomalous diffusion models, both for non-crowded and crowded membranes. In the last part of this review we address the upcoming field of membrane distortion by elongated membrane-binding particles. We discuss how membrane compartmentalisation and the particle-membrane binding energy may impact the dynamics and response of lipid membranes. This article is part of a Special Issue entitled: Biosimulations edited by Ilpo Vattulainen and Tomasz Róg. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  2. Subordinated continuous-time AR processes and their application to modeling behavior of mechanical system

    NASA Astrophysics Data System (ADS)

    Gajda, Janusz; Wyłomańska, Agnieszka; Zimroz, Radosław

    2016-12-01

    Many real data exhibit behavior adequate to subdiffusion processes. Very often it is manifested by so-called ;trapping events;. The visible evidence of subdiffusion we observe not only in financial time series but also in technical data. In this paper we propose a model which can be used for description of such kind of data. The model is based on the continuous time autoregressive time series with stable noise delayed by the infinitely divisible inverse subordinator. The proposed system can be applied to real datasets with short-time dependence, visible jumps and mentioned periods of stagnation. In this paper we extend the theoretical considerations in analysis of subordinated processes and propose a new model that exhibits mentioned properties. We concentrate on the main characteristics of the examined subordinated process expressed mainly in the language of the measures of dependence which are main tools used in statistical investigation of real data. We present also the simulation procedure of the considered system and indicate how to estimate its parameters. The theoretical results we illustrate by the analysis of real technical data.

  3. Probing transcription factor diffusion dynamics in the living mammalian embryo with photoactivatable fluorescence correlation spectroscopy.

    PubMed

    Kaur, Gurpreet; Costa, Mauro W; Nefzger, Christian M; Silva, Juan; Fierro-González, Juan Carlos; Polo, Jose M; Bell, Toby D M; Plachta, Nicolas

    2013-01-01

    Transcription factors use diffusion to search the DNA, yet the mechanisms controlling transcription factor diffusion during mammalian development remain poorly understood. Here we combine photoactivation and fluorescence correlation spectroscopy to study transcription factor diffusion in developing mouse embryos. We show that the pluripotency-associated transcription factor Oct4 displays both fast and Brownian and slower subdiffusive behaviours that are controlled by DNA interactions. Following cell lineage specification, the slower DNA-interacting diffusion fraction distinguishes pluripotent from extraembryonic cell nuclei. Similar to Oct4, Sox2 shows slower diffusion in pluripotent cells while Cdx2 displays opposite dynamics, suggesting that slow diffusion may represent a general feature of transcription factors in lineages where they are essential. Slow Oct4 subdiffusive behaviours are conserved in embryonic stem cells and induced pluripotent stem cells (iPS cells), and lost during differentiation. We also show that Oct4 diffusion depends on its interaction with ERG-associated protein with SET domain. Photoactivation and fluorescence correlation spectroscopy provides a new intravital approach to study transcription factor diffusion in complex in vivo systems.

  4. Seismo-Electromagnetic Emissions Related to Seismic Waves can Trigger TLEs

    NASA Astrophysics Data System (ADS)

    Sorokin, Leonid V.

    2009-04-01

    This paper deals with the rare high intensity electromagnetic pulses associated with earthquakes, whose spectrum signature differs from that of atmospherics produced by lightning discharges. On the basis of actual data records, cases of the generation of anomalous seismo-electromagnetic emissions are described. These natural sub-millisecond electromagnetic pulses were associated with the passage of seismic waves from earthquakes to Moscow, the place where the electromagnetic field observations were made. Space-time coupling has been revealed between exact seismic waves from the earthquakes, lightning triggering and Transient Luminous Events triggering.

  5. S193: another non-eclipsing SW Sex star

    NASA Astrophysics Data System (ADS)

    Martínez-Pais, I. G.; Rodríguez-Gil, P.; Casares, J.

    1999-05-01

    We present time-resolved optical spectroscopy of the cataclysmic variable S193. The emission lines are remarkably similar to those of V795 Her and exhibit high-velocity S-waves and complex absorptions that are modulated with the orbital period. Evidence for transient anomalous spectral features is seen during the first two nights of our run. We propose that S193 and V795 Her are non-eclipsing SW Sex stars. Finally, we show that the `disc overflow' model fails to explain the Balmer line orbital behaviour in these low-inclination systems.

  6. Self Consistent Ambipolar Transport and High Frequency Oscillatory Transient in Graphene Electronics

    DTIC Science & Technology

    2015-08-17

    study showed that in the presence of an ac field, THz oscillations exhibit soft resonances at a frequency roughly equal to half of the inverse of the ...exhibit soft resonances at a frequency roughly equal to half of the inverse of the carrier transit time to the LO phonon energy. It also showed that in...carriers in graphene undergo an anomalous parametric resonance. Such resonance occurs at about half the frequency ωF = 2πeF/~ωOP , where 2π/ωF is the time

  7. Slow-Wave Phase Shifters, Based on Thin Ferroelectric Films, for Reflectarray Antennas. Frequency-Agile Radio: Systems and Technlogies, WMG 139

    NASA Technical Reports Server (NTRS)

    Romanofsky, Robert R.

    2006-01-01

    We have developed relatively broadband K- and Ka-band phase shifters using synthetic (slow-wave) transmission lines employing coupled microstripline "varactors". The tunable coupled microstripline circuits are based on laser ablated BaSrTiO films on lanthanum aluminate substrates. A model and design criteria for these novel circuits will be presented, along with measured performance including anomalous phase delay characteristics. The critical role of phase shifter loss and transient response in reflectarray antennas will be emphasized.

  8. Electron heating and thermal relaxation of gold nanorods revealed by two-dimensional electronic spectroscopy.

    PubMed

    Lietard, Aude; Hsieh, Cho-Shuen; Rhee, Hanju; Cho, Minhaeng

    2018-03-01

    To elucidate the complex interplay between the size and shape of gold nanorods and their electronic, photothermal, and optical properties for molecular imaging, photothermal therapy, and optoelectronic devices, it is a prerequisite to characterize ultrafast electron dynamics in gold nanorods. Time-resolved transient absorption (TA) studies of plasmonic electrons in various nanostructures have revealed the time scales for electron heating, lattice vibrational excitation, and phonon relaxation processes in condensed phases. However, because linear spectroscopic and time-resolved TA signals are vulnerable to inhomogeneous line-broadening, pure dephasing and direct electron heating effects are difficult to observe. Here we show that femtosecond two-dimensional electronic spectroscopy, with its unprecedented time resolution and phase sensitivity, can be used to collect direct experimental evidence for ultrafast electron heating, anomalously strong coherent and transient electronic plasmonic responses, and homogenous dephasing processes resulting from electron-vibration couplings even for polydisperse gold nanorods.

  9. Arctic-North Pacific Coupled Impacts on the Late Autumn Cold in North America

    NASA Technical Reports Server (NTRS)

    Sung, Mi-Kyung; Kim, Baek-Min; Baik, Eun-Hyuk; Lim, Young-Kwon; Kim, Seong-Joong

    2016-01-01

    The Pacific Decadal Oscillation (PDO) is known to bring an anomalously cold (warm) period to southeastern (northwestern) North America during the cold season of its positive phase through a Rossby wave linkage. This study provides evidence that the remote connection between the North Pacific and the downstream temperature over central North America is strengthened by the warm arctic conditions over the Chukchi and East Siberian Sea, especially in the late autumn season. The modulation effect of the Arctic manifests itself as an altered Rossby wave response to a transient vorticity forcing that results from an equatorward storm track shift, which is induced collaboratively by the PDO and the warm Arctic. This observational finding is supported by two independent modeling experiments: 1) an idealized coupled GCM experiment being nudged toward the warm arctic surface condition and 2) a simple stationary wave model (SWM) experiment forced by transient eddy forcing.

  10. Time-changed geometric fractional Brownian motion and option pricing with transaction costs

    NASA Astrophysics Data System (ADS)

    Gu, Hui; Liang, Jin-Rong; Zhang, Yun-Xiu

    2012-08-01

    This paper deals with the problem of discrete time option pricing by a fractional subdiffusive Black-Scholes model. The price of the underlying stock follows a time-changed geometric fractional Brownian motion. By a mean self-financing delta-hedging argument, the pricing formula for the European call option in discrete time setting is obtained.

  11. FRACTIONAL PEARSON DIFFUSIONS.

    PubMed

    Leonenko, Nikolai N; Meerschaert, Mark M; Sikorskii, Alla

    2013-07-15

    Pearson diffusions are governed by diffusion equations with polynomial coefficients. Fractional Pearson diffusions are governed by the corresponding time-fractional diffusion equation. They are useful for modeling sub-diffusive phenomena, caused by particle sticking and trapping. This paper provides explicit strong solutions for fractional Pearson diffusions, using spectral methods. It also presents stochastic solutions, using a non-Markovian inverse stable time change.

  12. Interhemispheric Changes in Atlantic Ocean Heat Content and Their Link to Global Monsoons

    NASA Astrophysics Data System (ADS)

    Lopez, H.; Lee, S. K.; Dong, S.; Goni, G. J.

    2015-12-01

    This study tested the hypothesis whether low frequency decadal variability of the South Atlantic meridional heat transport (SAMHT) influences decadal variability of the global monsoons. A multi-century run from a state-of-the-art coupled general circulation model is used as basis for the analysis. Our findings indicate that multi-decadal variability of the South Atlantic Ocean plays a key role in modulating atmospheric circulation via interhemispheric changes in Atlantic Ocean heat content. Weaker SAMHT produces anomalous ocean heat divergence over the South Atlantic resulting in negative ocean heat content anomaly about 15 years later. This, in turn, forces a thermally direct anomalous interhemispheric Hadley circulation in the atmosphere, transporting heat from the northern hemisphere (NH) to the southern hemisphere (SH) and moisture from the SH to the NH, thereby intensify (weaken) summer (winter) monsoon in the NH and winter (summer) monsoon in the SH. Results also show that anomalous atmospheric eddies, both transient and stationary, transport heat northward in both hemispheres producing eddy heat flux convergence (divergence) in the NH (SH) around 15-30°, reinforcing the anomalous Hadley circulation. The effect of eddies on the NH (SH) poleward of 30° is opposite with heat flux divergence (convergence), which must be balanced by sinking (rising) motion, consistent with a poleward (equatorward) displacement of the jet stream and mean storm track. The mechanism described here could easily be interpreted for the case of strong SAMHT, with the reverse influence on the interhemispheric atmospheric circulation and monsoons. Overall, SAMHT decadal variability leads its atmospheric response by about 15 years, suggesting that the South Atlantic is a potential predictor of global climate variability.

  13. In vitro transcription in the presence of DNA oligonucleotides can generate strong anomalous initiation sites.

    PubMed

    Chow, C W; Clark, M P; Rinaldo, J E; Chalkley, R

    1996-03-01

    In the present study, we have explored an unexpected observation in transcription initiation that is mediated by single-stranded oligonucleotides. Initially, our goal was to understand the function of different upstream regulatory elements/initiation sites in the rat xanthine dehydrogenase/oxidase (XDH/XO) promoter. We performed in vitro transcription with HeLa nuclear extracts in the presence of different double-stranded oligonucleotides against upstream elements as competitors. A new and unusual transcription initiation site was detected by primer extension. This new initiation site maps to the downstream region of the corresponding competitor. Subsequent analyses have indicated that the induction of a new transcription initiation site is anomalous which is due to the presence of a small amount of single-stranded oligonucleotide in the competitor. We found that this anomalous initiation site is insensitive to the orientation of the promoter and requires only a small amount of single-stranded oligonucleotide (< 2-fold molar excess relative to template). We surmise that a complementary interaction between the single-stranded oligonucleotide and transiently denatured promoter template may be responsible for this sequence-specific transcription initiation artifact. To study the regulation of transcription initiation by in vitro transcription approaches, we propose that one should probe the effect of removing transacting factors by adding an excess of a cognate oligonucleotide which does not bear exact sequence identity to the template.

  14. Central action of dendrotoxin: selective reduction of a transient K conductance in hippocampus and binding to localized acceptors.

    PubMed

    Halliwell, J V; Othman, I B; Pelchen-Matthews, A; Dolly, J O

    1986-01-01

    Dendrotoxin, a small single-chain protein from the venom of Dendroaspis angusticeps, is highly toxic following intracerebroventricular injection into rats. Voltage-clamp analysis of CA1 neurons in hippocampal slices, treated with tetrodotoxin, revealed that nanomolar concentrations of dendrotoxin reduce selectively a transient, voltage-dependent K conductance. Epileptiform activity known to be induced by dendrotoxin can be attributed to such an action. Membrane currents not affected directly by the toxin include (i) Ca-activated K conductance; (ii) noninactivating voltage-dependent K conductance; (iii) inactivating and noninactivating Ca conductances; (iv) persistent inward (anomalous) rectifier current. Persistence of the effects of the toxin when Cd was included to suppress spontaneous transmitter release indicates a direct action on the neuronal membrane. Using biologically active, 125I-labeled dendrotoxin, protein acceptor sites of high affinity were detected on cerebrocortical synaptosomal membranes and sections of rat brain. In hippocampus, toxin binding was shown autoradiographically to reside in synapse-rich and white matter regions, with lower levels in cell body layers. This acceptor is implicated in the action of toxin because its affinities for dendrotoxin congeners are proportional to their central neurotoxicities and potencies in reducing the transient, voltage-dependent K conductance.

  15. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mulchaey, John S.; Kollmeier, Juna A.; Kasliwal, Mansi M., E-mail: mulchaey@obs.carnegiescience.edu

    X-ray measurements suggest that the abundance of calcium in the intracluster medium is higher than can be explained using favored models for core-collapse and Type Ia supernovae alone. We investigate whether the ''calcium conundrum'' in the intracluster medium can be alleviated by including a contribution from the recently discovered subclass of supernovae known as calcium-rich gap transients. Although the calcium-rich gap transients make up only a small fraction of all supernovae events, we find that their high calcium yields are sufficient to reproduce the X-ray measurements found for nearby rich clusters. We find the χ{sup 2} goodness-of-fit metric improves frommore » 84 to 2 by including this new class. Moreover, calcium-rich supernovae preferentially occur in the outskirts of galaxies making it easier for the nucleosynthesis products of these events to be incorporated in the intracluster medium via ram-pressure stripping. The discovery of calcium-rich gap transients in clusters and groups far from any individual galaxy suggests that supernovae associated with intracluster stars may play an important role in enriching the intracluster medium. Calcium-rich gap transients may also help explain anomalous calcium abundances in many other astrophysical systems including individual stars in the Milky Way, the halos of nearby galaxies, and the circumgalactic medium. Our work highlights the importance of considering the diversity of supernovae types and corresponding yields when modeling the abundance of the intracluster medium and other gas reservoirs.« less

  16. Anomalous dimensionality dependence of diffusion in a rugged energy landscape: How pathological is one dimension?

    NASA Astrophysics Data System (ADS)

    Seki, Kazuhiko; Bagchi, Kaushik; Bagchi, Biman

    2016-05-01

    Diffusion in one dimensional rugged energy landscape (REL) is predicted to be pathologically different (from any higher dimension) with a much larger chance of encountering broken ergodicity [D. L. Stein and C. M. Newman, AIP Conf. Proc. 1479, 620 (2012)]. However, no quantitative study of this difference has been reported, despite the prevalence of multidimensional physical models in the literature (like a high dimensional funnel guiding protein folding/unfolding). Paradoxically, some theoretical studies of these phenomena still employ a one dimensional diffusion description for analytical tractability. We explore the dimensionality dependent diffusion on REL by carrying out an effective medium approximation based analytical calculations and compare them with the available computer simulation results. We find that at an intermediate level of ruggedness (assumed to have a Gaussian distribution), where diffusion is well-defined, the value of the effective diffusion coefficient depends on dimensionality and changes (increases) by several factors (˜5-10) in going from 1d to 2d. In contrast, the changes in subsequent transitions (like 2d to 3d and 3d to 4d and so on) are far more modest, of the order of 10-20% only. When ruggedness is given by random traps with an exponential distribution of barrier heights, the mean square displacement (MSD) is sub-diffusive (a well-known result), but the growth of MSD is described by different exponents in one and higher dimensions. The reason for such strong ruggedness induced retardation in the case of one dimensional REL is discussed. We also discuss the special limiting case of infinite dimension (d = ∞) where the effective medium approximation becomes exact and where theoretical results become simple. We discuss, for the first time, the role of spatial correlation in the landscape on diffusion of a random walker.

  17. Anomalous dimensionality dependence of diffusion in a rugged energy landscape: How pathological is one dimension?

    PubMed

    Seki, Kazuhiko; Bagchi, Kaushik; Bagchi, Biman

    2016-05-21

    Diffusion in one dimensional rugged energy landscape (REL) is predicted to be pathologically different (from any higher dimension) with a much larger chance of encountering broken ergodicity [D. L. Stein and C. M. Newman, AIP Conf. Proc. 1479, 620 (2012)]. However, no quantitative study of this difference has been reported, despite the prevalence of multidimensional physical models in the literature (like a high dimensional funnel guiding protein folding/unfolding). Paradoxically, some theoretical studies of these phenomena still employ a one dimensional diffusion description for analytical tractability. We explore the dimensionality dependent diffusion on REL by carrying out an effective medium approximation based analytical calculations and compare them with the available computer simulation results. We find that at an intermediate level of ruggedness (assumed to have a Gaussian distribution), where diffusion is well-defined, the value of the effective diffusion coefficient depends on dimensionality and changes (increases) by several factors (∼5-10) in going from 1d to 2d. In contrast, the changes in subsequent transitions (like 2d to 3d and 3d to 4d and so on) are far more modest, of the order of 10-20% only. When ruggedness is given by random traps with an exponential distribution of barrier heights, the mean square displacement (MSD) is sub-diffusive (a well-known result), but the growth of MSD is described by different exponents in one and higher dimensions. The reason for such strong ruggedness induced retardation in the case of one dimensional REL is discussed. We also discuss the special limiting case of infinite dimension (d = ∞) where the effective medium approximation becomes exact and where theoretical results become simple. We discuss, for the first time, the role of spatial correlation in the landscape on diffusion of a random walker.

  18. On the role of adhesion in single-file dynamics

    NASA Astrophysics Data System (ADS)

    Fouad, Ahmed M.; Noel, John A.

    2017-08-01

    For a one-dimensional interacting system of Brownian particles with hard-core interactions (a single-file model), we study the effect of adhesion on both the collective diffusion (diffusion of the entire system with respect to its center of mass) and the tracer diffusion (diffusion of the individual tagged particles). For the case with no adhesion, all properties of these particle systems that are independent of particle labeling (symmetric in all particle coordinates and velocities) are identical to those of non-interacting particles (Lebowitz and Percus, 1967). We clarify this last fact twice. First, we derive our analytical predictions that show that the probability-density functions of single-file (ρsf) and ordinary (ρord) diffusion are identical, ρsf =ρord, predicting a nonanomalous (ordinary) behavior for the collective single-file diffusion, where the average second moment with respect to the center of mass, < x(t) 2 > , is calculated from ρ for both diffusion processes. Second, for single-file diffusion, we show, both analytically and through large-scale simulations, that < x(t) 2 > grows linearly with time, confirming the nonanomalous behavior. This nonanomalous collective behavior comes in contrast to the well-known anomalous sub-diffusion behavior of the individual tagged particles (Harris, 1965). We introduce adhesion to single-file dynamics as a second inter-particle interaction rule and, interestingly, we show that adding adhesion does reduce the magnitudes of both < x(t) 2 > and the mean square displacement per particle Δx2; but the diffusion behavior remains intact independent of adhesion in both cases. Moreover, we study the dependence of both the collective diffusion constant D and the tracer diffusion constant DT on the adhesion coefficient α.

  19. Analysis of passive scalar advection in parallel shear flows: Sorting of modes at intermediate time scales

    NASA Astrophysics Data System (ADS)

    Camassa, Roberto; McLaughlin, Richard M.; Viotti, Claudio

    2010-11-01

    The time evolution of a passive scalar advected by parallel shear flows is studied for a class of rapidly varying initial data. Such situations are of practical importance in a wide range of applications from microfluidics to geophysics. In these contexts, it is well-known that the long-time evolution of the tracer concentration is governed by Taylor's asymptotic theory of dispersion. In contrast, we focus here on the evolution of the tracer at intermediate time scales. We show how intermediate regimes can be identified before Taylor's, and in particular, how the Taylor regime can be delayed indefinitely by properly manufactured initial data. A complete characterization of the sorting of these time scales and their associated spatial structures is presented. These analytical predictions are compared with highly resolved numerical simulations. Specifically, this comparison is carried out for the case of periodic variations in the streamwise direction on the short scale with envelope modulations on the long scales, and show how this structure can lead to "anomalously" diffusive transients in the evolution of the scalar onto the ultimate regime governed by Taylor dispersion. Mathematically, the occurrence of these transients can be viewed as a competition in the asymptotic dominance between large Péclet (Pe) numbers and the long/short scale aspect ratios (LVel/LTracer≡k), two independent nondimensional parameters of the problem. We provide analytical predictions of the associated time scales by a modal analysis of the eigenvalue problem arising in the separation of variables of the governing advection-diffusion equation. The anomalous time scale in the asymptotic limit of large k Pe is derived for the short scale periodic structure of the scalar's initial data, for both exactly solvable cases and in general with WKBJ analysis. In particular, the exactly solvable sawtooth flow is especially important in that it provides a short cut to the exact solution to the eigenvalue problem for the physically relevant vanishing Neumann boundary conditions in linear-shear channel flow. We show that the life of the corresponding modes at large Pe for this case is shorter than the ones arising from shear free zones in the fluid's interior. A WKBJ study of the latter modes provides a longer intermediate time evolution. This part of the analysis is technical, as the corresponding spectrum is dominated by asymptotically coalescing turning points in the limit of large Pe numbers. When large scale initial data components are present, the transient regime of the WKBJ (anomalous) modes evolves into one governed by Taylor dispersion. This is studied by a regular perturbation expansion of the spectrum in the small wavenumber regimes.

  20. Entropy of electromyography time series

    NASA Astrophysics Data System (ADS)

    Kaufman, Miron; Zurcher, Ulrich; Sung, Paul S.

    2007-12-01

    A nonlinear analysis based on Renyi entropy is applied to electromyography (EMG) time series from back muscles. The time dependence of the entropy of the EMG signal exhibits a crossover from a subdiffusive regime at short times to a plateau at longer times. We argue that this behavior characterizes complex biological systems. The plateau value of the entropy can be used to differentiate between healthy and low back pain individuals.

  1. Anomalous Transient Amplification of Waves in Non-normal Photonic Media

    NASA Astrophysics Data System (ADS)

    Makris, K. G.; Ge, L.; Türeci, H. E.

    2014-10-01

    Dissipation is a ubiquitous phenomenon in dynamical systems encountered in nature because no finite system is fully isolated from its environment. In optical systems, a key challenge facing any technological application has traditionally been the mitigation of optical losses. Recent work has shown that a new class of optical materials that consist of a precisely balanced distribution of loss and gain can be exploited to engineer novel functionalities for propagating and filtering electromagnetic radiation. Here we show a generic property of optical systems that feature an unbalanced distribution of loss and gain, described by non-normal operators, namely, that an overall lossy optical system can transiently amplify certain input signals by several orders of magnitude. We present a mathematical framework to analyze the dynamics of wave propagation in media with an arbitrary distribution of loss and gain, and we construct the initial conditions to engineer such non-normal power amplifiers. Our results point to a new design space for engineered optical systems employed in photonics and quantum optics.

  2. Nannoplankton malformation during the Paleocene-Eocene Thermal Maximum and its paleoecological and paleoceanographic significance

    USGS Publications Warehouse

    Bralower, Timothy J.; Self-Trail, Jean

    2016-01-01

    The Paleocene-Eocene Thermal Maximum (PETM) is characterized by a transient group of nannoplankton, belonging to the genus Discoaster. Our investigation of expanded shelf sections provides unprecedented detail of the morphology and phylogeny of the transient Discoasterduring the PETM and their relationship with environmental change. We observe a much larger range of morphological variation than previously documented suggesting that the taxa belonged to a plexus of highly gradational morphotypes rather than individual species. We propose that the plexus represents malformed ecophenotypes of a single species that migrated to a deep photic zone refuge during the height of PETM warming and eutrophication. Anomalously, high rates of organic matter remineralization characterized these depths during the event and led to lower saturation levels, which caused malformation. The proposed mechanism explains the co-occurrence of malformed Discoaster with pristine species that grew in the upper photic zone; moreover, it illuminates why malformation is a rare phenomenon in the paleontological record.

  3. Near interface traps in SiO{sub 2}/4H-SiC metal-oxide-semiconductor field effect transistors monitored by temperature dependent gate current transient measurements

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Fiorenza, Patrick; La Magna, Antonino; Vivona, Marilena

    This letter reports on the impact of gate oxide trapping states on the conduction mechanisms in SiO{sub 2}/4H-SiC metal-oxide-semiconductor field effect transistors (MOSFETs). The phenomena were studied by gate current transient measurements, performed on n-channel MOSFETs operated in “gate-controlled-diode” configuration. The measurements revealed an anomalous non-steady conduction under negative bias (V{sub G} > |20 V|) through the SiO{sub 2}/4H-SiC interface. The phenomenon was explained by the coexistence of a electron variable range hopping and a hole Fowler-Nordheim (FN) tunnelling. A semi-empirical modified FN model with a time-depended electric field is used to estimate the near interface traps in the gate oxide (N{sub trap} ∼ 2 × 10{supmore » 11} cm{sup −2}).« less

  4. Nannoplankton malformation during the Paleocene-Eocene Thermal Maximum and its paleoecological and paleoceanographic significance

    NASA Astrophysics Data System (ADS)

    Bralower, Timothy J.; Self-Trail, Jean M.

    2016-10-01

    The Paleocene-Eocene Thermal Maximum (PETM) is characterized by a transient group of nannoplankton, belonging to the genus Discoaster. Our investigation of expanded shelf sections provides unprecedented detail of the morphology and phylogeny of the transient Discoaster during the PETM and their relationship with environmental change. We observe a much larger range of morphological variation than previously documented suggesting that the taxa belonged to a plexus of highly gradational morphotypes rather than individual species. We propose that the plexus represents malformed ecophenotypes of a single species that migrated to a deep photic zone refuge during the height of PETM warming and eutrophication. Anomalously, high rates of organic matter remineralization characterized these depths during the event and led to lower saturation levels, which caused malformation. The proposed mechanism explains the co-occurrence of malformed Discoaster with pristine species that grew in the upper photic zone; moreover, it illuminates why malformation is a rare phenomenon in the paleontological record.

  5. Proton permeation of lipid bilayers.

    PubMed

    Deamer, D W

    1987-10-01

    Proton permeation of the lipid bilayer barrier has two unique features. First, permeability coefficients measured at neutral pH ranges are six to seven orders of magnitude greater than expected from knowledge of other monovalent cations. Second, proton conductance across planar lipid bilayers varies at most by a factor of 10 when pH is varied from near 1 to near 11. Two mechanisms have been proposed to account for this anomalous behavior: proton conductance related to contaminants of lipid bilayers, and proton translocation along transient hydrogen-bonded chains (tHBC) of associated water molecules in the membrane. The weight of evidence suggests that trace contaminants may contribute to proton conductance across planar lipid membranes at certain pH ranges, but cannot account for the anomalous proton flux in liposome systems. Two new results will be reported here which were designed to test the tHBC model. These include measurements of relative proton/potassium permeability in the gramicidin channel, and plots of proton flux against the magnitude of pH gradients. (1) The relative permeabilities of protons and potassium through the gramicidin channel, which contains a single strand of hydrogen-bonded water molecules, were found to differ by at least four orders of magnitude when measured at neutral pH ranges. This result demonstrates that a hydrogen-bonded chain of water molecules can provide substantial discrimination between protons and other cations. It was also possible to calculate that if approximately 7% of bilayer water was present in a transient configuration similar to that of the gramicidin channel, it could account for the measured proton flux. (2) The plot of proton conductance against pH gradient across liposome membranes was superlinear, a result that is consistent with one of three alternative tHBC models for proton conductance described by Nagle elsewhere in this volume.

  6. Propagation of THz pulses in rectangular subwavelength dielectric waveguides

    NASA Astrophysics Data System (ADS)

    Lu, Yao; Wu, Qiang; Zhang, Qi; Wang, Ride; Zhao, Wenjuan; Zhang, Deng; Pan, Chongpei; Qi, Jiwei; Xu, Jingjun

    2018-06-01

    Rectangular subwavelength waveguides are necessary for the development of micro/nanophotonic devices and on-chip platforms. Using a time-resolved imaging system, we studied the transient properties and the propagation modes of THz pulses in rectangular subwavelength dielectric waveguides. The dynamic process of THz pulses was systematically recorded to a movie. In addition, an anomalous group velocity dispersion was demonstrated in rectangular subwavelength waveguides. By using the effective index method, we theoretically calculated the modes in rectangular subwavelength waveguides, which agree well with the experiments and simulations. This work provides the opportunity to improve the analysis and design of the integrated platforms and photonic devices.

  7. Translocation of single-stranded DNA through single-walled carbon nanotubes.

    PubMed

    Liu, Haitao; He, Jin; Tang, Jinyao; Liu, Hao; Pang, Pei; Cao, Di; Krstic, Predrag; Joseph, Sony; Lindsay, Stuart; Nuckolls, Colin

    2010-01-01

    We report the fabrication of devices in which one single-walled carbon nanotube spans a barrier between two fluid reservoirs, enabling direct electrical measurement of ion transport through the tube. A fraction of the tubes pass anomalously high ionic currents. Electrophoretic transport of small single-stranded DNA oligomers through these tubes is marked by large transient increases in ion current and was confirmed by polymerase chain reaction analysis. Each current pulse contains about 10(7) charges, an enormous amplification of the translocated charge. Carbon nanotubes simplify the construction of nanopores, permit new types of electrical measurements, and may open avenues for control of DNA translocation.

  8. Systematic study of anharmonic features in a principal component analysis of gramicidin A.

    PubMed

    Kurylowicz, Martin; Yu, Ching-Hsing; Pomès, Régis

    2010-02-03

    We use principal component analysis (PCA) to detect functionally interesting collective motions in molecular-dynamics simulations of membrane-bound gramicidin A. We examine the statistical and structural properties of all PCA eigenvectors and eigenvalues for the backbone and side-chain atoms. All eigenvalue spectra show two distinct power-law scaling regimes, quantitatively separating large from small covariance motions. Time trajectories of the largest PCs converge to Gaussian distributions at long timescales, but groups of small-covariance PCs, which are usually ignored as noise, have subdiffusive distributions. These non-Gaussian distributions imply anharmonic motions on the free-energy surface. We characterize the anharmonic components of motion by analyzing the mean-square displacement for all PCs. The subdiffusive components reveal picosecond-scale oscillations in the mean-square displacement at frequencies consistent with infrared measurements. In this regime, the slowest backbone mode exhibits tilting of the peptide planes, which allows carbonyl oxygen atoms to provide surrogate solvation for water and cation transport in the channel lumen. Higher-frequency modes are also apparent, and we describe their vibrational spectra. Our findings expand the utility of PCA for quantifying the essential features of motion on the anharmonic free-energy surface made accessible by atomistic molecular-dynamics simulations. Copyright (c) 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  9. Breathing modes of Kolumbo submarine volcano (Santorini, Greece).

    PubMed

    Bakalis, Evangelos; Mertzimekis, Theo J; Nomikou, Paraskevi; Zerbetto, Francesco

    2017-04-13

    Submarine volcanoes, such as Kolumbo (Santorini, Greece) are natural laboratories for fostering multidisciplinary studies. Their investigation requires the most innovative marine technology together with advanced data analysis. Conductivity and temperature of seawater were recorded directly above Kolumbo's hydrothermal vent system. The respective time series have been analyzed in terms of non-equilibrium techniques. The energy dissipation of the volcanic activity is monitored by the temperature variations of seawater. The venting dynamics of chemical products is monitored by water conductivity. The analysis of the time series in terms of stochastic processes delivers scaling exponents with turning points between consecutive regimes for both conductivity and temperature. Changes of conductivity are shown to behave as a universal multifractal and their variance is subdiffusive as the scaling exponents indicate. Temperature is constant over volcanic rest periods and a universal multifractal behavior describes its changes in line with a subdiffusive character otherwise. The universal multifractal description illustrates the presence of non-conservative conductivity and temperature fields showing that the system never retains a real equilibrium state. The existence of a repeated pattern of the combined effect of both seawater and volcanic activity is predicted. The findings can shed light on the dynamics of chemical products emitted from the vents and point to the presence of underlying mechanisms that govern potentially hazardous, underwater volcanic environments.

  10. Structure and Dynamics of Interacting Nanoparticles in Semidilute Polymer Solutions

    DOE PAGES

    Pollng-Skutvik, Ryan; Mongcopa, Katrina Irene S.; Faraone, Antonio; ...

    2016-08-17

    We investigate the structure and dynamics of silica nanoparticles and polymer chains in semidilute solutions of high molecular weight polystyrene in 2-butanone to determine the effect of long-range interparticle interactions on the coupling between particle and polymer dynamics. Particles at concentrations of 1–10 wt % are well dispersed in the semidilute polymer solutions and exhibit long-range electrostatic repulsions between particles. Because the particles are comparably sized to the radius of gyration of the polymer, the particle dynamics is predicted to couple to that of the polymer. We verify that the polymer structure and dynamics are not significantly affected by themore » particles, indicating that the particle–polymer coupling does not change with increasing particle loading. We find that the coupling between the dynamics of comparably sized particles and polymer results in subdiffusive particle dynamics, as expected. Over the interparticle distance, however, the particle dynamics is hindered and not fully described by the relaxation of the surrounding polymer chains. Instead, the particle dynamics is inversely related to the structure factor, suggesting that physical particle–polymer coupling on short length scales and interparticle interactions on long length scales both present energetic barriers to particle motion that lead to subdiffusive dynamics and de Gennes narrowing, respectively.« less

  11. Sub-diffusive scattering parameter maps recovered using wide-field high-frequency structured light imaging.

    PubMed

    Kanick, Stephen Chad; McClatchy, David M; Krishnaswamy, Venkataramanan; Elliott, Jonathan T; Paulsen, Keith D; Pogue, Brian W

    2014-10-01

    This study investigates the hypothesis that structured light reflectance imaging with high spatial frequency patterns [Formula: see text] can be used to quantitatively map the anisotropic scattering phase function distribution [Formula: see text] in turbid media. Monte Carlo simulations were used in part to establish a semi-empirical model of demodulated reflectance ([Formula: see text]) in terms of dimensionless scattering [Formula: see text] and [Formula: see text], a metric of the first two moments of the [Formula: see text] distribution. Experiments completed in tissue-simulating phantoms showed that simultaneous analysis of [Formula: see text] spectra sampled at multiple [Formula: see text] in the frequency range [0.05-0.5] [Formula: see text] allowed accurate estimation of both [Formula: see text] in the relevant tissue range [0.4-1.8] [Formula: see text], and [Formula: see text] in the range [1.4-1.75]. Pilot measurements of a healthy volunteer exhibited [Formula: see text]-based contrast between scar tissue and surrounding normal skin, which was not as apparent in wide field diffuse imaging. These results represent the first wide-field maps to quantify sub-diffuse scattering parameters, which are sensitive to sub-microscopic tissue structures and composition, and therefore, offer potential for fast diagnostic imaging of ultrastructure on a size scale that is relevant to surgical applications.

  12. Breathing modes of Kolumbo submarine volcano (Santorini, Greece)

    NASA Astrophysics Data System (ADS)

    Bakalis, Evangelos; Mertzimekis, Theo J.; Nomikou, Paraskevi; Zerbetto, Francesco

    2017-04-01

    Submarine volcanoes, such as Kolumbo (Santorini, Greece) are natural laboratories for fostering multidisciplinary studies. Their investigation requires the most innovative marine technology together with advanced data analysis. Conductivity and temperature of seawater were recorded directly above Kolumbo’s hydrothermal vent system. The respective time series have been analyzed in terms of non-equilibrium techniques. The energy dissipation of the volcanic activity is monitored by the temperature variations of seawater. The venting dynamics of chemical products is monitored by water conductivity. The analysis of the time series in terms of stochastic processes delivers scaling exponents with turning points between consecutive regimes for both conductivity and temperature. Changes of conductivity are shown to behave as a universal multifractal and their variance is subdiffusive as the scaling exponents indicate. Temperature is constant over volcanic rest periods and a universal multifractal behavior describes its changes in line with a subdiffusive character otherwise. The universal multifractal description illustrates the presence of non-conservative conductivity and temperature fields showing that the system never retains a real equilibrium state. The existence of a repeated pattern of the combined effect of both seawater and volcanic activity is predicted. The findings can shed light on the dynamics of chemical products emitted from the vents and point to the presence of underlying mechanisms that govern potentially hazardous, underwater volcanic environments.

  13. Statistical analysis of particle trajectories in living cells

    NASA Astrophysics Data System (ADS)

    Briane, Vincent; Kervrann, Charles; Vimond, Myriam

    2018-06-01

    Recent advances in molecular biology and fluorescence microscopy imaging have made possible the inference of the dynamics of molecules in living cells. Such inference allows us to understand and determine the organization and function of the cell. The trajectories of particles (e.g., biomolecules) in living cells, computed with the help of object tracking methods, can be modeled with diffusion processes. Three types of diffusion are considered: (i) free diffusion, (ii) subdiffusion, and (iii) superdiffusion. The mean-square displacement (MSD) is generally used to discriminate the three types of particle dynamics. We propose here a nonparametric three-decision test as an alternative to the MSD method. The rejection of the null hypothesis, i.e., free diffusion, is accompanied by claims of the direction of the alternative (subdiffusion or superdiffusion). We study the asymptotic behavior of the test statistic under the null hypothesis and under parametric alternatives which are currently considered in the biophysics literature. In addition, we adapt the multiple-testing procedure of Benjamini and Hochberg to fit with the three-decision-test setting, in order to apply the test procedure to a collection of independent trajectories. The performance of our procedure is much better than the MSD method as confirmed by Monte Carlo experiments. The method is demonstrated on real data sets corresponding to protein dynamics observed in fluorescence microscopy.

  14. Calibrating emergent phenomena in stock markets with agent based models

    PubMed Central

    Sornette, Didier

    2018-01-01

    Since the 2008 financial crisis, agent-based models (ABMs), which account for out-of-equilibrium dynamics, heterogeneous preferences, time horizons and strategies, have often been envisioned as the new frontier that could revolutionise and displace the more standard models and tools in economics. However, their adoption and generalisation is drastically hindered by the absence of general reliable operational calibration methods. Here, we start with a different calibration angle that qualifies an ABM for its ability to achieve abnormal trading performance with respect to the buy-and-hold strategy when fed with real financial data. Starting from the common definition of standard minority and majority agents with binary strategies, we prove their equivalence to optimal decision trees. This efficient representation allows us to exhaustively test all meaningful single agent models for their potential anomalous investment performance, which we apply to the NASDAQ Composite index over the last 20 years. We uncover large significant predictive power, with anomalous Sharpe ratio and directional accuracy, in particular during the dotcom bubble and crash and the 2008 financial crisis. A principal component analysis reveals transient convergence between the anomalous minority and majority models. A novel combination of the optimal single-agent models of both classes into a two-agents model leads to remarkable superior investment performance, especially during the periods of bubbles and crashes. Our design opens the field of ABMs to construct novel types of advanced warning systems of market crises, based on the emergent collective intelligence of ABMs built on carefully designed optimal decision trees that can be reversed engineered from real financial data. PMID:29499049

  15. Calibrating emergent phenomena in stock markets with agent based models.

    PubMed

    Fievet, Lucas; Sornette, Didier

    2018-01-01

    Since the 2008 financial crisis, agent-based models (ABMs), which account for out-of-equilibrium dynamics, heterogeneous preferences, time horizons and strategies, have often been envisioned as the new frontier that could revolutionise and displace the more standard models and tools in economics. However, their adoption and generalisation is drastically hindered by the absence of general reliable operational calibration methods. Here, we start with a different calibration angle that qualifies an ABM for its ability to achieve abnormal trading performance with respect to the buy-and-hold strategy when fed with real financial data. Starting from the common definition of standard minority and majority agents with binary strategies, we prove their equivalence to optimal decision trees. This efficient representation allows us to exhaustively test all meaningful single agent models for their potential anomalous investment performance, which we apply to the NASDAQ Composite index over the last 20 years. We uncover large significant predictive power, with anomalous Sharpe ratio and directional accuracy, in particular during the dotcom bubble and crash and the 2008 financial crisis. A principal component analysis reveals transient convergence between the anomalous minority and majority models. A novel combination of the optimal single-agent models of both classes into a two-agents model leads to remarkable superior investment performance, especially during the periods of bubbles and crashes. Our design opens the field of ABMs to construct novel types of advanced warning systems of market crises, based on the emergent collective intelligence of ABMs built on carefully designed optimal decision trees that can be reversed engineered from real financial data.

  16. Illumination of rheological mantle heterogeneity by the M7.2 2010 El Mayor-Cucapah earthquake

    USGS Publications Warehouse

    Pollitz, Fred F.; Bürgmann, Roland; Thatcher, Wayne R.

    2012-01-01

    Major intracontinental strike-slip faults tend to mark boundaries between lithospheric blocks of contrasting mechanical properties along much of their length. Both crustal and mantle heterogeneities can form such boundaries, but the role of crustal versus mantle strength contrasts for localizing strain sufficiently to generate major faults remains unclear. Using the crustal velocity field observed through the Global Positioning System (GPS) in the epicentral area of the M7.2 2010 El Mayor-Cucapah earthquake, Baja California, we find that transient deformation observed after the event is anomalously small in areas of relatively high seismic velocity in the shallow upper mantle (∼50 km depth). This pattern is best explained with a laterally heterogeneous viscoelastic structure that mimics the seismic structure. The mantle of the Southern Colorado River Desert (SCRD) and Peninsular Ranges (PR), which bound the fault system to its east and west, respectively, have anomalously high viscosity and seismic velocity. We hypothesize that compared with the rest of the San Andreas fault (SAF) system to its north, the strike-slip fault system in northern Baja California is narrow because of the presence of the PR and SCRD high-viscosity regions which bound it.

  17. Anomalous Growth Rate of Ag Nanocrystals Revealed by in situ STEM

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ge, Mingyuan; Lu, Ming; Chu, Yong

    In situ microscopy of colloidal nanocrystal growth offers a unique opportunity to acquire direct and straightforward data for assessing classical growth models. For this study, we observe the growth trajectories of individual Ag nanoparticles in solution using in situ scanning transmission electron microscopy. For the first time, we provide experimental evidence of growth rates of Ag nanoparticles in the presence of Pt in solution that are significantly faster than predicted by Lifshitz-Slyozov-Wagner theory. We attribute these observed anomalous growth rates to the synergistic effects of the catalytic properties of Pt and the electron beam itself. Transiently reduced Pt atoms servemore » as active sites for Ag ions to grow, thereby playing a key role in controlling the growth kinetics. Electron beam illumination greatly increases the local concentration of free radicals, thereby strongly influencing particle growth rate and the resulting particle morphology. Through a systematic investigation, we demonstrate the feasibility of utilizing these synergistic effects for controlling the growth rates and particle morphologies at the nanoscale. Our findings not only expand the current scope of crystal growth theory, but may also lead to a broader scientific application of nanocrystal synthesis.« less

  18. Anomalous Growth Rate of Ag Nanocrystals Revealed by in situ STEM

    DOE PAGES

    Ge, Mingyuan; Lu, Ming; Chu, Yong; ...

    2017-11-27

    In situ microscopy of colloidal nanocrystal growth offers a unique opportunity to acquire direct and straightforward data for assessing classical growth models. For this study, we observe the growth trajectories of individual Ag nanoparticles in solution using in situ scanning transmission electron microscopy. For the first time, we provide experimental evidence of growth rates of Ag nanoparticles in the presence of Pt in solution that are significantly faster than predicted by Lifshitz-Slyozov-Wagner theory. We attribute these observed anomalous growth rates to the synergistic effects of the catalytic properties of Pt and the electron beam itself. Transiently reduced Pt atoms servemore » as active sites for Ag ions to grow, thereby playing a key role in controlling the growth kinetics. Electron beam illumination greatly increases the local concentration of free radicals, thereby strongly influencing particle growth rate and the resulting particle morphology. Through a systematic investigation, we demonstrate the feasibility of utilizing these synergistic effects for controlling the growth rates and particle morphologies at the nanoscale. Our findings not only expand the current scope of crystal growth theory, but may also lead to a broader scientific application of nanocrystal synthesis.« less

  19. How East Asian westerly jet's meridional position affects the summer rainfall in Yangtze-Huaihe River Valley?

    NASA Astrophysics Data System (ADS)

    Wang, Shixin; Zuo, Hongchao; Zhao, Shuman; Zhang, Jiankai; Lu, Sha

    2017-03-01

    Existing studies show that the change in the meridional position of East Asian westerly jet (EAWJ) is associated with rainfall anomalies in Yangtze-Huaihe River Valley (YHRV) in summer. However, the dynamic mechanism has not been resolved yet. The present study reveals underlying mechanisms for this impact for early summer and midsummer, separately. Mechanism1: associated with EAWJ's anomalously southward displacement, the 500-hPa westerly wind over YHRV is strengthened through midtropospheric horizontal circulation anomalies; the westerly anomalies are related to the formation of warm advection anomalies over YHRV, which cause increased rainfall through adiabatic ascent motion and convective activities; the major difference in these processes between early summer and midsummer is the midtropospheric circulation anomaly pattern. Mechanism 2: associated with EAWJ's anomalously southward displacement, the large day-to-day variability of midtropospheric temperature advection in midlatitudes is displaced southward by the jet's trapping transient eddies; this change enhances the day-to-day variability of temperature advection over YHRV, which in turn causes the increased rainfall in most part of YHRV through "lower-bound effect" (rainfall amount can not become negative); there is not much difference in these processes between early summer and midsummer.

  20. InSAR-detected Local Ground Inflation Prior to Small Phreatic Eruption

    NASA Astrophysics Data System (ADS)

    Kobayashi, T.; Morishita, Y.

    2017-12-01

    Phreatic eruptions may be related to transient pressure changes in subsurface regions of hydrothermal systems. It means that crustal deformation presumably proceeds with the pressure increase under the ground, which can be a kind of precursor. In this context, Mt. Hakone volcano is a good study target. This is because the crustal deformation has been successfully detected two months before small phreatic eruptions at an active geothermal area, called Owaku-dani. The anomalous activity such as an increase of seismicity started in the end of April, 2015. With this anomalous activity, SAR (ALOS-2) observations was conducted, and small but significant crustal deformation was detected in a local area with a diameter of 200 m with a displacement of 5 cm. The amount of deformation has increased with time although the spatial size has not changed, and resultantly the amount reached up to 60 cm. Finally, in the end of June, eruptions occurred just at the local crustal deformation area. It should be noted that the eruption started from the InSAR-detected inflational area. This is an excellent case that we were able to identify the location of small phreatic eruption in advance by detecting anomalous ground inflation. Further, we investigated whether or not the inflational deformation preceded the anomalous activity observed since the end of April. Applying InSAR time series analysis incorporating the phase linking method to C-band SAR data of RADARSAT-2 (RS2) and Sentinel-1A (S1), we successfully detected small but significant inflational ground deformation that has already proceeded since the end of 2014 at the latest. The amount of deformation reaches up to 3 cm during 4 months. The most striking point is that the spatial distribution is quite similar to the deformation detected by ALOS-2. It strongly suggests that the pressure increase in subsurface have already started before the anomalous activities such as seismic swarm and widely-distributed deformation have been identified. Acknowledgements: ALOS-2 and RS2 data were provided from JAXA under a cooperative research contract between GSI and JAXA, and in addition, for RS2 under a contract between JAXA and CSA. The ownership of ALOS-2 and RS2 data belong to JAXA and MDA, respectively. This study was supported by JSPS KAKENHI Grant Numbers JP16K1779.

  1. Study of recombination characteristics in MOCVD grown GaN epi-layers on Si

    NASA Astrophysics Data System (ADS)

    Gaubas, E.; Ceponis, T.; Dobrovolskas, D.; Malinauskas, T.; Meskauskaite, D.; Miasojedovas, S.; Mickevicius, J.; Pavlov, J.; Rumbauskas, V.; Simoen, E.; Zhao, M.

    2017-12-01

    The radiative and non-radiative recombination carrier decay lifetimes in GaN epi-layers grown by metal-organic chemical vapour deposition technology on Si substrates were measured by contactless techniques of time-resolved photoluminescence and microwave-probed transients of photoconductivity. The lifetime variations were obtained to be dependent on growth regimes. These variations have been related to varied densities of edge dislocations associated with growth temperature. It has been also revealed that the lateral carrier lifetime and photoluminescence intensity distribution is determined by the formation of dislocation clusters dependent on the growth conditions. For low excitation level, the asymptotic component within the excess carrier decay transients is attributed to carrier trapping and anomalous diffusion through random-walk processes within dislocation cluster regions and barriers at dislocation cores. The two-componential decay process at high excitation conditions, where excess carriers may suppress barriers, proceeds through a nonlinear recombination, where band-to-band transitions determine the nonlinearity of the process, while the asymptotic component is ascribed to the impact of D-A pair PL within the long-wavelength wing of the UV-PL band.

  2. Upset due to a single particle caused propagated transients in a bulk CMOS microprocessor

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Leavy, J.F.; Hoffmann, L.F.; Shoran, R.W.

    1991-12-01

    This paper reports on data pattern advances observed in preset, single event upset (SEU) hardened clocked flip-flops, during static Cf-252 exposures on a bulk CMOS microprocessor, that were attributable to particle caused anomalous clock signals, or propagated transients. SPICE simulations established that particle strikes in the output nodes of a clock control logic flip-flop could produce transients of sufficient amplitude and duration to be accepted as legitimate pulses by clock buffers fed by the flip-flop's output nodes. The buffers would then output false clock pulses, thereby advancing the state of the present flip-flops. Masking the clock logic on one ofmore » the test chips made the flip-flop data advance cease, confirming the clock logic as the source of the SEU. By introducing N{sub 2} gas, at reduced pressures, into the SEU test chamber to attenuate Cf-252 particle LET's, a 24-26 MeV-cm{sup 2}/mg LET threshold was deduced. Subsequent tests, at the 88-inch cyclotron at Berkeley, established an LET threshold of 30 MeV-cm{sup 2}/mg (283 MeV Cu at 0{degrees}) for the generation of false clocks. Cyclotron SEU tests are considered definitive, while Cf-252 data usually is not. However, in this instance Cf-252 tests proved analytically useful, providing SEU characterization data that was both timely and inexpensive.« less

  3. Self-affinity in the dengue fever time series

    NASA Astrophysics Data System (ADS)

    Azevedo, S. M.; Saba, H.; Miranda, J. G. V.; Filho, A. S. Nascimento; Moret, M. A.

    2016-06-01

    Dengue is a complex public health problem that is common in tropical and subtropical regions. This disease has risen substantially in the last three decades, and the physical symptoms depict the self-affine behavior of the occurrences of reported dengue cases in Bahia, Brazil. This study uses detrended fluctuation analysis (DFA) to verify the scale behavior in a time series of dengue cases and to evaluate the long-range correlations that are characterized by the power law α exponent for different cities in Bahia, Brazil. The scaling exponent (α) presents different long-range correlations, i.e. uncorrelated, anti-persistent, persistent and diffusive behaviors. The long-range correlations highlight the complex behavior of the time series of this disease. The findings show that there are two distinct types of scale behavior. In the first behavior, the time series presents a persistent α exponent for a one-month period. For large periods, the time series signal approaches subdiffusive behavior. The hypothesis of the long-range correlations in the time series of the occurrences of reported dengue cases was validated. The observed self-affinity is useful as a forecasting tool for future periods through extrapolation of the α exponent behavior. This complex system has a higher predictability in a relatively short time (approximately one month), and it suggests a new tool in epidemiological control strategies. However, predictions for large periods using DFA are hidden by the subdiffusive behavior.

  4. THE EFFECT OF INTERMITTENT GYRO-SCALE SLAB TURBULENCE ON PARALLEL AND PERPENDICULAR COSMIC-RAY TRANSPORT

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Le Roux, J. A.

    Earlier work based on nonlinear guiding center (NLGC) theory suggested that perpendicular cosmic-ray transport is diffusive when cosmic rays encounter random three-dimensional magnetohydrodynamic turbulence dominated by uniform two-dimensional (2D) turbulence with a minor uniform slab turbulence component. In this approach large-scale perpendicular cosmic-ray transport is due to cosmic rays microscopically diffusing along the meandering magnetic field dominated by 2D turbulence because of gyroresonant interactions with slab turbulence. However, turbulence in the solar wind is intermittent and it has been suggested that intermittent turbulence might be responsible for the observation of 'dropout' events in solar energetic particle fluxes on small scales.more » In a previous paper le Roux et al. suggested, using NLGC theory as a basis, that if gyro-scale slab turbulence is intermittent, large-scale perpendicular cosmic-ray transport in weak uniform 2D turbulence will be superdiffusive or subdiffusive depending on the statistical characteristics of the intermittent slab turbulence. In this paper we expand and refine our previous work further by investigating how both parallel and perpendicular transport are affected by intermittent slab turbulence for weak as well as strong uniform 2D turbulence. The main new finding is that both parallel and perpendicular transport are the net effect of an interplay between diffusive and nondiffusive (superdiffusive or subdiffusive) transport effects as a consequence of this intermittency.« less

  5. Prediction and validation of diffusion coefficients in a model drug delivery system using microsecond atomistic molecular dynamics simulation and vapour sorption analysis.

    PubMed

    Forrey, Christopher; Saylor, David M; Silverstein, Joshua S; Douglas, Jack F; Davis, Eric M; Elabd, Yossef A

    2014-10-14

    Diffusion of small to medium sized molecules in polymeric medical device materials underlies a broad range of public health concerns related to unintended leaching from or uptake into implantable medical devices. However, obtaining accurate diffusion coefficients for such systems at physiological temperature represents a formidable challenge, both experimentally and computationally. While molecular dynamics simulation has been used to accurately predict the diffusion coefficients, D, of a handful of gases in various polymers, this success has not been extended to molecules larger than gases, e.g., condensable vapours, liquids, and drugs. We present atomistic molecular dynamics simulation predictions of diffusion in a model drug eluting system that represent a dramatic improvement in accuracy compared to previous simulation predictions for comparable systems. We find that, for simulations of insufficient duration, sub-diffusive dynamics can lead to dramatic over-prediction of D. We present useful metrics for monitoring the extent of sub-diffusive dynamics and explore how these metrics correlate to error in D. We also identify a relationship between diffusion and fast dynamics in our system, which may serve as a means to more rapidly predict diffusion in slowly diffusing systems. Our work provides important precedent and essential insights for utilizing atomistic molecular dynamics simulations to predict diffusion coefficients of small to medium sized molecules in condensed soft matter systems.

  6. Highly elastic polymer solutions under shear: Polymer migration, viscoelastic instabilities, and anomalous rheology

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    MacDonald, M.J.; Muller, S.J.

    1996-12-31

    The use of highly elastic polymer solutions has been remarkably successful in elucidating the behavior of polymeric materials under flowing conditions. Here, we present the results of an extensive experimental study into the shear behavior of an athermal, dilute, binary polymer solution that is believed to be free of many of these effects. Under extended shearing, we observe the migration of polymer species: after shearing for several hundred hours, concentrations that are more than double the initial uniform value can be achieved. Although the solutions are well-described by dumbbell models in shear flows on short-time scales, theoretical predictions substantially underestimatemore » the rate of migration. Flow visualization and rheometric experiments suggest that the origin of this discrepancy could be the anomalous long-time rheology of these solutions. While these fluids display the well-known elastic instability in cone and plate flow above a critical Deborah number, extended shearing reveals that the toroidal secondary flow is eventually replaced by a purely azimuthal shearing flow. In addition, when sheared below the critical condition for the instability, the solutions exhibit a slow but reversible decay in normal stresses. The shear-induced migration of polymer species has been predicted by numerous theoretical studies. However, observations on the highly elastic polymer solutions that are most likely to show polymer migration, are complicated by a number of different physical processes that occur as a result of shearing. These phenomena, which include shear-induced phase separation, elastically-induced hydrodynamic instabilities, mixed solvent effects, shear-induced aggregation, and anomalous transient shear and normal stress behavior are often observed at times earlier than and at shear rates less than those where migration is predicted to occur; hence, the experimental detection of polymer migration has been thwarted by these other physical processes.« less

  7. Characteristics and Future Changes of Great Mississippi Flood Events in a Global Coupled Climate Model

    NASA Astrophysics Data System (ADS)

    van der Wiel, K.; Kapnick, S. B.; Vecchi, G.; Smith, J. A.

    2017-12-01

    The Mississippi-Missouri river catchment houses millions of people and much of the U.S. national agricultural production. Severe flooding events can therefore have large negative societal, natural and economic impacts. GFDL FLOR, a global coupled climate model (atmosphere, ocean, land, sea ice with integrated river routing module) is used to investigate the characteristics of great Mississippi floods with an average return period of 100 years. Model experiments under pre-industrial greenhouse gas forcing were conducted for 3400 years, such that the most extreme flooding events were explicitly modeled and the land and/or atmospheric causes could be investigated. It is shown that melt of snow pack and frozen sub-surface water in the Missouri and Upper Mississippi basins prime the river system, subsequently sensitizing it to above average precipitation in the Ohio and Tennessee basins. The months preceding the greatest flooding events are above average wet, leading to moist sub-surface conditions. Anomalous melt depends on the availability of frozen water in the catchment, therefore anomalous amounts of sub-surface frozen water and anomalous large snow pack in winter (Nov-Feb) make the river system susceptible for these great flooding events in spring (Feb-Apr). An additional experiment of 1200 years under transient greenhouse gas forcing (RCP4.5, 5 members) was done to investigate potential future change in flood risk. Based on a peak-over-threshold method, it is found that the number of great flooding events decreases in a warmer future. This decrease coincides with decreasing occurrence of large melt events, but is despite increasing numbers of large precipitation events. Though the model results indicate a decreasing risk for the greatest flooding events, the predictability of events might decrease in a warmer future given the changing characters of melt and precipitation.

  8. Advances in analysis of pre-earthquake thermal anomalies by analyzing IR satellite data

    NASA Astrophysics Data System (ADS)

    Ouzounov, D.; Bryant, N.; Filizzola, C.; Pergola, N.; Taylor, P.; Tramutoli, V.

    Presented work addresses the possible relationship between tectonic stress, electro-chemical and thermodynamic processes in the atmosphere and increasing infrared (IR) flux as part of a larger family of electromagnetic (EM) phenomena related to earthquake activity. Thermal infra-red (TIR) surveys performed by polar orbiting (NOAA/AVHRR, MODIS) and geosynchronous weather satellites (GOES, METEOSAT) seems to indicate the appearance (from days to weeks before the event) of "anomalous" space-time TIR transients associated with the place (epicentral area, linear structures and fault systems) and the time of occurrence of a number of major earthquakes with M>5 and focal depths no deeper than 50km. As Earth emitted in 8-14 microns range the TIR signal measured from satellite strongly vary depending on meteorological conditions and other factors (space-time changes in atmospheric transmittance, time/season, solar and satellite zenithal angles and etc) independent from seismic activity, a preliminary definition of "anomalous TIR signal" should be given. To provide reliable discrimination of thermal anomalous area from the natural events (seasonal changes, local morphology) new robust approach (RAT) has been recently proposed (and successfully applied in the field of the monitoring of the major environmental risks) that permits to give a statistically based definition of thermal info-red (TIR) anomaly and reduce of false events detection. New techniques also were specifically developed to assure the precise co-registration of all satellite scenes and permit accurate time-series analysis of satellite observations. As final results we present examples of most recent 2000/2004 worldwide strong earthquakes and the techniques used to capture the tracks of thermal emission mid-IR anomalies and methodology for practical future use of such phenomena in the early warning systems.

  9. Outburst of the 2 s Anomalous X-ray Pulsar 1E 1547.0-5408

    NASA Technical Reports Server (NTRS)

    Halpern, J. P.; Gotthelf, E. V.; Camilo, F.; Reynolds, J.; Ransom, S. M.

    2008-01-01

    Following our discovery of radio pulsations from the newly recognized anomalous X-ray pulsar (AXP) 1E 1547.0-5408, we initiated X-ray monitoring with the Swift X-ray telescope and obtained a single target-of-opportunity observation with the Newton X-ray Multi-Mirror Mission (XMM-Newton). In comparison with its historic minimum flux of 3 x 10(exp -l3)ergs/sq cm/s, the source was found to be in a record high state, f(sub x)(1-8 keV) = 5 x 10(exp -12)ergs/sq cm/s, or L(sub x) = 1.7 x 10(exp 35)(d/9 kpc )(sup 2)ergs/s, and declining by 25% in 1 month. Extrapolating the decay, we bound the total energy in this outburst to 1042 ergs < E < ergs. The spectra (fitted with a Comptonized blackbody) show that an increase in the temperature and area of a hot region, to 0.5 keV and -16% of the surface area of the neutron star, respectively, are primarily responsible for its increase in luminosity. The energy, spectrum, and timescale of decay are consistent with a deep crustal heating event, similar to an interpretation of the X-ray turn-on of the transient AXP XTE J18 10- 197. Simultaneous with the 4.6 hr ATdA4-Newton observation, we observed at 6.4 GHz with the Parkes telescope, measuring the phase relationship of the radio and X-ray pulse. The X-ray pulsed fraction of 1E 1547.0-5408 is only approx. 7 %, while its radio pulse is relatively broad for such a slow pulsar, which may indicate a nearly aligned rotator. As also inferred from the transient behavior of XTE J18 10-197, the only other AXP known to emit in the radio, the magnetic field rearrangement responsible for this X-ray outburst of 1E 1547.0-5408 is probably the cause of its radio turn-on.

  10. Quantification of the Bioturbation Activity of Lumbriculus Variegatus Worms Using Fluorescent Particulate Tracers

    NASA Astrophysics Data System (ADS)

    Hernandez-Gonzalez, L. M.; Roche, K. R.; Xie, M.; Packman, A. I.

    2014-12-01

    Important biological, physical and chemical processes, such as fluxes of oxygen, nutrients and contaminants, occur across sediment-water interfaces. These processes are influenced by bioturbation activities of benthic animals. Bioturbation is thought to be significant in releasing metals to the water column from contaminated sediments, but metals contamination also affects organism activity. Consequently, the aim of this study was to consider the interactions of biological activity, sediment chemistry, pore water transport, and chemical reactions in sediment mixing and the flux and toxicity of metals in sediments. Prior studies have modeled bioturbation as a diffusive process. However, diffusion models often do not describe accurately sediment mixing due to bioturbation. To this end, we used the continuous time random walk (CTRW) model to assess sediment mixing caused by bioturbation activity of Lumbriculus variegatus worms. We performed experiments using fine-grained sediments with different levels of zinc contamination from Lake DePue, which is a Superfund Site in Illinois. The tests were conducted in an aerated fresh water chamber. Fluorescent particulate tracers were added to the sediment surface to quantify mixing processes and the influence of metals contaminants on L. variegatus bioturbation activity. We observed sediment mixing and organism activity by time-lapse photography over 14 days. Then, we analyzed the images to characterize the fluorescent particle concentration as a function of sediment depth and time. Results reveal that sediment mixing caused by L. variegatus is subdiffusive in time and superdiffusive in space. These results suggest that anomalous sediment mixing is probably a ubiquitous process, as this behavior has only been observed previously in marine sediments. Also, the experiments indicate that bioturbation and sediment mixing decreased in the presence of higher metals concentrations in sediments. This process is expected to decrease efflux of metals from highly contaminated sediments by reducing biological activity.

  11. One-electron propagation in Fermi, Pasta, Ulam disordered chains with Gaussian acoustic pulse pumping

    NASA Astrophysics Data System (ADS)

    Silva, L. D. Da; Dos Santos, J. L. L.; Ranciaro Neto, A.; Sales, M. O.; de Moura, F. A. B. F.

    In this work, we consider a one-electron moving on a Fermi, Pasta, Ulam disordered chain under effect of electron-phonon interaction and a Gaussian acoustic pulse pumping. We describe electronic dynamics using quantum mechanics formalism and the nonlinear atomic vibrations using standard classical physics. Solving numerical equations related to coupled quantum/classical behavior of this system, we study electronic propagation properties. Our calculations suggest that the acoustic pumping associated with the electron-lattice interaction promote a sub-diffusive electronic dynamics.

  12. Discovery of a Transient Magnetar: XTE J1810-197

    NASA Technical Reports Server (NTRS)

    Ibrahim, Alaa I.; Markwardt, Craig B.; Swank, Jean H.; Ransom, Scott; Roberts, Mallory; Kaspi, Victoria; Woods, Peter M.; Safi-Harb, Samar; Balman, Solen; Parke, William C.

    2004-01-01

    We report the discovery of a new X-ray pulsar, XTE J1810-197, that was serendipitously discovered on 2003 July 15 by the Rossi X-Ray Timing Explorer (RXTE) while observing the soft gamma repeater SGR 1806-20. The pulsar has a 5.54 s spin period, a soft X-ray spectrum (with a photon index of approx. = 4). and is detectable in earlier RXTE observations back to 2003 January but not before. These show that a transient outburst began between 2002 November 17 and 2003 January 23 and that the source's persistent X-ray flux has been declining since then. The pulsar exhibits a high spin-down rate P approx.= l0(exp -11) s/s with no evidence of Doppler shifts due to a binary companion. The rapid spin-down rate and slow spin period imply a supercritical characteristic magnetic field B approx. = 3 x l0(exp 14) G and a young age tau less than or = 7600 yr. Follow-up Chandra observations provided an accurate position of the source. Within its error radius, the 1.5 m Russian-Turkish Optical Telescope found a limiting magnitude R(sub c) = 21.5. All such properties are strikingly similar to those of anomalous X-ray pulsars ad soft gamma repeaters, providing strong evidence that the source is a new magnetar. However, archival ASCA and ROSAT observations found the source nearly 2 orders of magnitude fainter. This transient behavior and the observed long-term flux variability of the source in absence of an observed SGR-like burst activity make it the first confirmed transient magnetar and suggest that other neutron stars that share the properties of XTE 51810- 197 during its inactive phase may be unidentified transient magnetars awaiting detection via a similar activity. This implies a larger population of magnetars than previously surmised and a possible evolutionary connection between magnetars and other neutron star families. Subject headings: pulsars: general -pulsars: individual (XTE 51810- 197) - stars: magnetic fields -

  13. Response of surface-to-borehole SOTEM method on 2D earth

    NASA Astrophysics Data System (ADS)

    Chen, Weiying; Younis Khan, Muhammad; Xue, Guoqiang

    2017-08-01

    Borehole TEM methods are mostly based on a ground loop source. In this paper, we propose a new surface-to-borehole SOTEM method that uses a horizontal grounded-wire source. In this method, the transmitter is deployed on the ground near a borehole and the receiver is moved along the borehole to record the transient signal. In order to gain a basic understanding of this method, we analyzed the response characteristics of a rectangular body in a homogeneous half space based on a pure two-dimensional (2D) modeling scheme. The electric field and magnetic field (time derivative) are obtained by using 2D finite-difference time-domain (FDTD) modeling. We demonstrated that the targets—especially the conductive targets—can be reflected according to the borehole SOTEM responses. The location and the electrical properties of the targets can also be estimated by qualitatively analyzing the response curves. However, the anomalous amplitude is weakened when the surface layer contains local inhomogeneous bodies or exhibits a conductive overburden. Compared with a loop source borehole TEM, electromagnetic fields for a borehole SOTEM decay more slowly and show greater sensitivity to anomalous bodies. This study provides aid for further data interpretation, and also indicates that surface-to-borehole SOTEM is an effective method for underground detection.

  14. Soft gamma-ray repeaters and anomalous X-ray pulsars as highly magnetized white dwarfs

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mukhopadhyay, Banibrata; Rao, A.R., E-mail: bm@physics.iisc.ernet.in, E-mail: arrao@tifr.res.in

    We explore the possibility that soft gamma-ray repeaters (SGRs) and anomalous X-ray pulsars (AXPs) are powered by highly magnetized white dwarfs (B-WDs). We take a sample of SGRs and AXPs and provide the possible parameter space in mass, radius, and surface magnetic field based on their observed properties (period and its derivative) and the assumption that these sources obey the mass-radius relation derived for the B-WDs. The radius and magnetic field of B-WDs are adequate to explain energies in SGRs/AXPs as the rotationally powered energy. In addition, B-WDs also adequately explain the perplexing radio transient GCRT J1745-3009 as a whitemore » dwarf pulsar. Note that the radius and magnetic fields of B-WDs are neither extreme (unlike of highly magnetized neutron stars) nor ordinary (unlike of magnetized white dwarfs, yet following the Chandrasekhar's mass-radius relation (C-WDs)). In order to explain SGRs/AXPs, while the highly magnetized neutron stars require an extra, observationally not well established yet, source of energy, the C-WDs predict large ultra-violet luminosity which is observationally constrained from a strict upper limit. Finally, we provide a set of basic differences between the magnetar and B-WD hypotheses for SGRs/AXPs.« less

  15. Possible NIR counterpart to the AXP 1E 1547.0-5408

    NASA Astrophysics Data System (ADS)

    Mignani, R. P.; Rea, N.; Israel, G. L.; Testa, V.; Esposito, P.

    2008-10-01

    On 2008 October 3rd, Swift-BAT triggered on several short bursts from the direction of the Anomalous X-ray Pulsar (AXP) 1E1547.0-5408 (Krimm et al. GCN 8311, 8312; Rea et al. Atel #1756). This is the second known transient radio AXP discovered to date (Gelfand & Gaensler 2007; Camilo et al. 2007), and it showed the previous X-ray outburst around June 2007 (Halpern et al. 2008). During the decay of the 2007 X-ray outburst we observed 1E 1547.0-5408 in the Ks band (on 2007 July 8th, 12th, and August 17th) with the NAOS -CONICA (NACO) instrument mounted at the ESO- VLT (Mignani, Rea, Testa, et al., 2008 submitted).

  16. The Outer Heliosphere: Solar Wind, Cosmic Ray and VLF Radio Emission Variations

    NASA Technical Reports Server (NTRS)

    McNutt, Ralph L., Jr.

    1995-01-01

    The Voyager 1 and 2 spacecraft now 45 astronomical units (AU) from Earth continue to monitor the outer heliosphere field and particles environment on a daily basis during their journey to the termination shock of the solar wind. Strong transient shocks continue to be detected in the solar wind plasma. The largest of these are associated with Global Merged Interaction Regions (GMIR's) which, in turn, block cosmic ray entry into the inner heliosphere and are apparently responsible for triggering the two major episodes of VLF radio emissions now thought to come from the heliopause. Distance estimates to the termination shock are consistent with those determined from observations of anomalous cosmic rays. Current observations and implications for heliospheric structure are discussed.

  17. Ergodicity breaking and ageing of underdamped Brownian dynamics with quenched disorder

    NASA Astrophysics Data System (ADS)

    Guo, Wei; Li, Yong; Song, Wen-Hua; Du, Lu-Chun

    2018-03-01

    The dynamics of an underdamped Brownian particle moving in one-dimensional quenched disorder under the action of an external force is investigated. Within the tailored parameter regime, the transiently anomalous diffusion and ergodicity breaking, spanning several orders of magnitude in time, have been obtained. The ageing nature of the system weakens as the dissipation of the system increases for other given parameters. Its origin is ascribed to the highly local heterogeneity of the disorder. Two kinds of approximations (in the stationary state), respectively, for large bias and large damping are derived. These results may be helpful in further understanding the nontrivial response of nonlinear dynamics, and also have potential applications to experiments and activities of biological processes.

  18. An infrared scattering by evaporating droplets at the initial stage of a pool fire suppression by water sprays

    NASA Astrophysics Data System (ADS)

    Dombrovsky, Leonid A.; Dembele, Siaka; Wen, Jennifer X.

    2018-06-01

    The computational analysis of downward motion and evaporation of water droplets used to suppress a typical transient pool fire shows local regions of a high volume fraction of relatively small droplets. These droplets are comparable in size with the infrared wavelength in the range of intense flame radiation. The estimated scattering of the radiation by these droplets is considerable throughout the entire spectrum except for a narrow region in the vicinity of the main absorption peak of water where the anomalous refraction takes place. The calculations of infrared radiation field in the model pool fire indicate the strong effect of scattering which can be observed experimentally to validate the fire computational model.

  19. Transient turbid water mass reduces temperature-induced coral bleaching and mortality in Barbados

    PubMed Central

    Vallès, Henri

    2016-01-01

    Global warming is seen as one of the greatest threats to the world’s coral reefs and, with the continued rise in sea surface temperature predicted into the future, there is a great need for further understanding of how to prevent and address the damaging impacts. This is particularly so for countries whose economies depend heavily on healthy reefs, such as those of the eastern Caribbean. Here, we compare the severity of bleaching and mortality for five dominant coral species at six representative reef sites in Barbados during the two most significant warm-water events ever recorded in the eastern Caribbean, i.e., 2005 and 2010, and describe prevailing island-scale sea water conditions during both events. In so doing, we demonstrate that coral bleaching and subsequent mortality were considerably lower in 2010 than in 2005 for all species, irrespective of site, even though the anomalously warm water temperature profiles were very similar between years. We also show that during the 2010 event, Barbados was engulfed by a transient dark green turbid water mass of riverine origin coming from South America. We suggest that reduced exposure to high solar radiation associated with this transient water mass was the primary contributing factor to the lower bleaching and mortality observed in all corals. We conclude that monitoring these episodic mesoscale oceanographic features might improve risk assessments of southeastern Caribbean reefs to warm-water events in the future. PMID:27326377

  20. FCC-HCP coexistence in dense thermo-responsive microgel crystals

    NASA Astrophysics Data System (ADS)

    Karthickeyan, D.; Joshi, R. G.; Tata, B. V. R.

    2017-06-01

    Analogous to hard-sphere suspensions, monodisperse thermo-responsive poly (N-isopropyl acrylamide) (PNIPAM) microgel particles beyond a volume fraction (ϕ) of 0.5 freeze into face centered cubic (FCC)-hexagonal close packed (HCP) coexistence under as prepared conditions and into an FCC structure upon annealing. We report here FCC-HCP coexistence to be stable in dense PNIPAM microgel crystals (ϕ > 0.74) with particles in their deswollen state (referred to as osmotically compressed microgel crystals) and the FCC structure with particles in their swollen state by performing annealing studies with different cooling rates. The structure of PNIPAM microgel crystals is characterized using static light scattering technique and UV-Visible spectroscopy and dynamics by dynamic light scattering (DLS). DLS studies reveal that the particle motion is diffusive at short times in crystals with ϕ < 0.74 and sub-diffusive at short times in PNIPAM crystals with ϕ > 0.74. The observed sub-diffusive behavior at short times is due to the overlap (interpenetration) of the dangling polymer chains between the shells of neighbouring PNIPAM microgel particles. Overlap is found to disappear upon heating the crystals well above their melting temperature, Tm due to reduction in the particle size. Annealing studies confirm that the overlap of dangling polymer chains between the shells of neighbouring PNIPAM spheres is responsible for the stability of FCC-HCP coexistence observed in osmotically compressed PNIPAM microgel crystals. Results are discussed in the light of recent reports of stabilizing the HCP structure in hard sphere crystals by adding interacting polymer chains.

  1. Ion migration in crystalline and amorphous HfOX

    NASA Astrophysics Data System (ADS)

    Schie, Marcel; Müller, Michael P.; Salinga, Martin; Waser, Rainer; De Souza, Roger A.

    2017-03-01

    The migration of ions in HfOx was investigated by means of large-scale, classical molecular-dynamics simulations over the temperature range 1000 ≤T /K ≤2000 . Amorphous HfOx was studied in both stoichiometric and oxygen-deficient forms (i.e., with x = 2 and x = 1.9875); oxygen-deficient cubic and monoclinic phases were also studied. The mean square displacement of oxygen ions was found to evolve linearly as a function of time for the crystalline phases, as expected, but displayed significant negative deviations from linear behavior for the amorphous phases, that is, the behavior was sub-diffusive. That oxygen-ion migration was observed for the stoichiometric amorphous phase argues strongly against applying the traditional model of vacancy-mediated migration in crystals to amorphous HfO2. In addition, cation migration, whilst not observed for the crystalline phases (as no cation defects were present), was observed for both amorphous phases. In order to obtain activation enthalpies of migration, the residence times of the migrating ions were analyzed. The analysis reveals four activation enthalpies for the two amorphous phases: 0.29 eV, 0.46 eV, and 0.66 eV (values very close to those obtained for the monoclinic structure) plus a higher enthalpy of at least 0.85 eV. In comparison, the cubic phase is characterized by a single value of 0.43 eV. Simple kinetic Monte Carlo simulations suggest that the sub-diffusive behavior arises from nanoscale confinement of the migrating ions.

  2. Universal Algorithm for Identification of Fractional Brownian Motion. A Case of Telomere Subdiffusion

    PubMed Central

    Burnecki, Krzysztof; Kepten, Eldad; Janczura, Joanna; Bronshtein, Irena; Garini, Yuval; Weron, Aleksander

    2012-01-01

    We present a systematic statistical analysis of the recently measured individual trajectories of fluorescently labeled telomeres in the nucleus of living human cells. The experiments were performed in the U2OS cancer cell line. We propose an algorithm for identification of the telomere motion. By expanding the previously published data set, we are able to explore the dynamics in six time orders, a task not possible earlier. As a result, we establish a rigorous mathematical characterization of the stochastic process and identify the basic mathematical mechanisms behind the telomere motion. We find that the increments of the motion are stationary, Gaussian, ergodic, and even more chaotic—mixing. Moreover, the obtained memory parameter estimates, as well as the ensemble average mean square displacement reveal subdiffusive behavior at all time spans. All these findings statistically prove a fractional Brownian motion for the telomere trajectories, which is confirmed by a generalized p-variation test. Taking into account the biophysical nature of telomeres as monomers in the chromatin chain, we suggest polymer dynamics as a sufficient framework for their motion with no influence of other models. In addition, these results shed light on other studies of telomere motion and the alternative telomere lengthening mechanism. We hope that identification of these mechanisms will allow the development of a proper physical and biological model for telomere subdynamics. This array of tests can be easily implemented to other data sets to enable quick and accurate analysis of their statistical characteristics. PMID:23199912

  3. Spike solutions in Gierer#x2013;Meinhardt model with a time dependent anomaly exponent

    NASA Astrophysics Data System (ADS)

    Nec, Yana

    2018-01-01

    Experimental evidence of complex dispersion regimes in natural systems, where the growth of the mean square displacement in time cannot be characterised by a single power, has been accruing for the past two decades. In such processes the exponent γ(t) in ⟨r2⟩ ∼ tγ(t) at times might be approximated by a piecewise constant function, or it can be a continuous function. Variable order differential equations are an emerging mathematical tool with a strong potential to model these systems. However, variable order differential equations are not tractable by the classic differential equations theory. This contribution illustrates how a classic method can be adapted to gain insight into a system of this type. Herein a variable order Gierer-Meinhardt model is posed, a generic reaction- diffusion system of a chemical origin. With a fixed order this system possesses a solution in the form of a constellation of arbitrarily situated localised pulses, when the components' diffusivity ratio is asymptotically small. The pattern was shown to exist subject to multiple step-like transitions between normal diffusion and sub-diffusion, as well as between distinct sub-diffusive regimes. The analytical approximation obtained permits qualitative analysis of the impact thereof. Numerical solution for typical cross-over scenarios revealed such features as earlier equilibration and non-monotonic excursions before attainment of equilibrium. The method is general and allows for an approximate numerical solution with any reasonably behaved γ(t).

  4. Case report: A prototypical spontaneous 'sensed presence' of a sentient being and concomitant electroencephalographic activity in the clinical laboratory.

    PubMed

    Persinger, Michael A; Tiller, Sandra G

    2008-01-01

    The sensed presence of a 'Sentient Being' has been hypothesized to be the transient awareness of the right hemispheric equivalent of the left hemispheric sense of self. When the clinical context is supportive for the expression of anomalous cognition, the experience is reported frequently by patients who display complex partial epileptic-like symptoms and signs following a mild closed head injury. This article describes a patient with a history of presences subsequent to a 'mild' closed head injury who reported strong experiences during an electroencephalographic screening within a very quiet and darkened setting at the end of a day of neuropsychological assessments. The right-sided presence was preceded by the sensation of an 'electric shock' through the right hand and then both hands. Whole body 'icy coldness' and then vibrations 'moved' through her entire body. The experiences were concomitant with paroxysmal irregular 4-5-Hz activity over the temporal lobes. This case illustrates that many sensed presences might be similar to 'epileptic auras' for patients who also display elevated complex partial epileptic-like experiences following closed head injuries and that close attention to typically ignored electroencephalographic 'transients' may be helpful indicators.

  5. Very fast optical flaring from a possible new Galactic magnetar.

    PubMed

    Stefanescu, A; Kanbach, G; Słowikowska, A; Greiner, J; McBreen, S; Sala, G

    2008-09-25

    Highly luminous rapid flares are characteristic of processes around compact objects like white dwarfs, neutron stars and black holes. In the high-energy regime of X-rays and gamma-rays, outbursts with variabilities on timescales of seconds or less are routinely observed, for example in gamma-ray bursts or soft gamma-ray repeaters. At optical wavelengths, flaring activity on such timescales has not been observed, other than from the prompt phase of one exceptional gamma-ray burst. This is mostly due to the fact that outbursts with strong, fast flaring are usually discovered in the high-energy regime; most optical follow-up observations of such transients use instruments with integration times exceeding tens of seconds, which are therefore unable to resolve fast variability. Here we show the observation of extremely bright and rapid optical flaring in the Galactic transient SWIFT J195509.6+261406. Our optical light curves are phenomenologically similar to high-energy light curves of soft gamma-ray repeaters and anomalous X-ray pulsars, which are thought to be neutron stars with extremely high magnetic fields (magnetars). This suggests that similar processes are in operation, but with strong emission in the optical, unlike in the case of other known magnetars.

  6. Photoluminescence properties of polystyrene-hosted fluorophore thin films

    NASA Astrophysics Data System (ADS)

    Chakraborty, Subha; Harris, Katherine; Huang, Mengbing

    2016-12-01

    We report on a photo-luminescence study of four different fluorophores: Coumarin 6, 2,5-Diphenyloxazole (PPO), 1,4-Bis(5-phenyl-2-oxazolyl)benzene (POPOP) and Para-terpehnyl (PTP), doped in a polystyrene-based thin film. All of the samples are prepared by spin coating from a non-polar polymer solution at various concentrations. Their emission spectra and transient properties are characterized by photoluminescence measurements. Red-shifts in the emission spectra are observed for all four types of fluorophores as their concentration increases. We explain this phenomenon based on concentration dependence of solvatochromic effects and the results show good agreement with existing literature. We also show that the singlet-singlet annihilation processes are possibly a prevalent mechanism in the high concentration regime that affects the steady state and transient emission characteristics of the fluors. With the exception of PTP, photoluminescence quenching occurs as the fluorophore concentration in the polymer is increased. Rate equations for excited state decay mechanisms are analysed by considering different radiative and non-radiative energy transfer mechanisms. The results show consistency with our experimental observations. PTP shows the best photoluminescence results as an efficient fluor in the thin film, whereas PPO shows the strongest concentration dependent quenching and an anomalous lifetime distribution.

  7. On the nonlinear forced response of the North Atlantic atmosphere to meridional shifts of the Gulf Stream path

    NASA Astrophysics Data System (ADS)

    Seo, H.; Kwon, Y. O.; Joyce, T. M.; Ummenhofer, C.

    2016-12-01

    This study examines the North Atlantic atmospheric circulation response to the meridional shift of Gulf Stream path using a large-ensemble, high-resolution, and hemispheric-scale WRF simulations. The model is forced with wintertime SST anomalies derived from a wide range of Gulf Stream shift scenarios. The key result of the model experiments, supported in part by an independent analysis of a reanalysis data set, is that the large-scale, quasi-steady North Atlantic circulation response is unambiguously nonlinear about the sign and amplitude of chosen SST anomalies. This nonlinear response prevails over the weak linear response and resembles the negative North Atlantic Oscillation, the leading intrinsic mode of variability in the model and the observations. Further analysis of the associated dynamics reveals that the nonlinear responses are accompanied by the anomalous southward shift of the North Atlantic eddy-driven jet stream, which is reinforced nearly equally by the high-frequency transient eddy feedback and the low-frequency high-latitude wave breaking events. The result highlights the importance of the intrinsically nonlinear transient eddy dynamics and eddy-mean flow interactions in generating the nonlinear forced response to the meridional shift in the Gulf Stream.

  8. Simulation of Flow and Long-Term Plutonium (Pu) Transport in the Vadose Zone at the Savannah River National Laboratory (SRNL)

    NASA Astrophysics Data System (ADS)

    Demirkanli, I.; Molz, F. J.; Kaplan, D. I.; Fjeld, R. A.; Serkiz, S. M.

    2006-05-01

    An improved understanding of flow and radionuclide transport in vadose zone sediments is fundamental to all types of future planning involving radioactive materials. One way to obtain such understanding is to perform long-term experimental studies of Pu transport in complex natural systems. With this in mind, a series of field experiments were initiated at the SRNL in the early 1980s. Lysimeters containing sources of different Pu oxidation states were placed in the shallow subsurface and left open to the natural environment for 2 to 11 years. At the end of the experiments, Pu activities were measured along vertical cores obtained from the lysimeters. Pu distributions were anomalous in nature, with transport from oxidized Pu sources being less than expected, and a small fraction of Pu from reduced sources moving more. Laboratory studies with lysimeter sediments suggested that surface-mediated, oxidation/reduction (redox) reactions could be responsible for the anomalous behavior, and this hypothesis is tested by performing both steady-state and transient Pu transport simulations that include retardation along with first-order redox reactions on mineral surfaces. Based on the simulations, we conclude that the surface-mediated, redox hypothesis is consistent with the observed downward Pu activity profiles in the experiments, and such profiles are captured well by a steady-state, net downward, flow model. (Discussion is presented as to why a steady model appears to work in a highly transient flow environment.) The redox model explains how Pu(V/VI) sources release activity that moves downward more slowly than expected based on adsorptive retardation alone, and how Pu(III/IV) sources result in a small fraction of activity that moves downward more rapidly than expected. The calibrated parameter values were robust and relatively well-defined throughout all four sets of simulations. Pu(V/VI) (i.e., oxidized Pu)retardation factors were about 15, and reduced Pu(III/IV) retardation factors were about 10,000. For these values, ko (1st order oxidation rate) averaged 2.4x10-7/hr with a standard deviation of 1.6x10-7, and kr (reduction rate)was 7.1x10-4/hr with a standard deviation of 1.6x10-4. Preliminary transient flow simulations showed a very slight increase in the fitted reaction rate constants, but otherwise reproduced the steady-state results. To date, neither approach is able to simulate the observed Pu movement above the source.

  9. An accurate computational method for the diffusion regime verification

    NASA Astrophysics Data System (ADS)

    Zhokh, Alexey A.; Strizhak, Peter E.

    2018-04-01

    The diffusion regime (sub-diffusive, standard, or super-diffusive) is defined by the order of the derivative in the corresponding transport equation. We develop an accurate computational method for the direct estimation of the diffusion regime. The method is based on the derivative order estimation using the asymptotic analytic solutions of the diffusion equation with the integer order and the time-fractional derivatives. The robustness and the computational cheapness of the proposed method are verified using the experimental methane and methyl alcohol transport kinetics through the catalyst pellet.

  10. Computing the non-Markovian coarse-grained interactions derived from the Mori-Zwanzig formalism in molecular systems: Application to polymer melts

    NASA Astrophysics Data System (ADS)

    Li, Zhen; Lee, Hee Sun; Darve, Eric; Karniadakis, George Em

    2017-01-01

    Memory effects are often introduced during coarse-graining of a complex dynamical system. In particular, a generalized Langevin equation (GLE) for the coarse-grained (CG) system arises in the context of Mori-Zwanzig formalism. Upon a pairwise decomposition, GLE can be reformulated into its pairwise version, i.e., non-Markovian dissipative particle dynamics (DPD). GLE models the dynamics of a single coarse particle, while DPD considers the dynamics of many interacting CG particles, with both CG systems governed by non-Markovian interactions. We compare two different methods for the practical implementation of the non-Markovian interactions in GLE and DPD systems. More specifically, a direct evaluation of the non-Markovian (NM) terms is performed in LE-NM and DPD-NM models, which requires the storage of historical information that significantly increases computational complexity. Alternatively, we use a few auxiliary variables in LE-AUX and DPD-AUX models to replace the non-Markovian dynamics with a Markovian dynamics in a higher dimensional space, leading to a much reduced memory footprint and computational cost. In our numerical benchmarks, the GLE and non-Markovian DPD models are constructed from molecular dynamics (MD) simulations of star-polymer melts. Results show that a Markovian dynamics with auxiliary variables successfully generates equivalent non-Markovian dynamics consistent with the reference MD system, while maintaining a tractable computational cost. Also, transient subdiffusion of the star-polymers observed in the MD system can be reproduced by the coarse-grained models. The non-interacting particle models, LE-NM/AUX, are computationally much cheaper than the interacting particle models, DPD-NM/AUX. However, the pairwise models with momentum conservation are more appropriate for correctly reproducing the long-time hydrodynamics characterised by an algebraic decay in the velocity autocorrelation function.

  11. Fluctuating hydrogen-bond networks govern anomalous electron transfer kinetics in a blue copper protein.

    PubMed

    Kretchmer, Joshua S; Boekelheide, Nicholas; Warren, Jeffrey J; Winkler, Jay R; Gray, Harry B; Miller, Thomas F

    2018-06-12

    We combine experimental and computational methods to address the anomalous kinetics of long-range electron transfer (ET) in mutants of Pseudomonas aeruginosa azurin. ET rates and driving forces for wild type (WT) and three N47X mutants (X = L, S, and D) of Ru(2,2'-bipyridine) 2 (imidazole)(His83) azurin are reported. An enhanced ET rate for the N47L mutant suggests either an increase of the donor-acceptor (DA) electronic coupling or a decrease in the reorganization energy for the reaction. The underlying atomistic features are investigated using a recently developed nonadiabatic molecular dynamics method to simulate ET in each of the azurin mutants, revealing unexpected aspects of DA electronic coupling. In particular, WT azurin and all studied mutants exhibit more DA compression during ET (>2 Å) than previously recognized. Moreover, it is found that DA compression involves an extended network of hydrogen bonds, the fluctuations of which gate the ET reaction, such that DA compression is facilitated by transiently rupturing hydrogen bonds. It is found that the N47L mutant intrinsically disrupts this hydrogen-bond network, enabling particularly facile DA compression. This work, which reveals the surprisingly fluctional nature of ET in azurin, suggests that hydrogen-bond networks can modulate the efficiency of long-range biological ET. Copyright © 2018 the Author(s). Published by PNAS.

  12. The mechanism of growth of the low-frequency East Asia-Pacific teleconnection and the triggering role of tropical intraseasonal oscillation

    NASA Astrophysics Data System (ADS)

    Wang, Jiabao; Wen, Zhiping; Wu, Renguang; Guo, Yuanyuan; Chen, Zesheng

    2016-06-01

    The East Asia-Pacific (EAP) pattern is a well-known meridional teleconnection over East Asia during boreal summer. In this study, the mechanism for growth of the EAP on intraseasonal timescale is investigated through a vorticity budget. It is found that the beta-effect and high-frequency transient eddies have primary contributions to the growth of the low-frequency EAP. The former leads to a westward shift of disturbances associated with the low-frequency EAP and the latter favors an amplification of disturbances, respectively. The interaction between low-frequency disturbances and zonal flow has a damping effect by dragging disturbances eastward. The impact of boreal summer intraseasonal oscillation (BSISO) on the triggering of the low-frequency EAP is also examined in this study based on observational analysis and a linear model experiment. It is shown that an elongated anomalous convection band located in the vicinity of Philippines associated with the dominant mode of BSISO has a significant impact on the initiation of low-frequency EAP via Rossby wave propagation, whereas anomalous convection located over the North Indian Ocean has a limited impact. Based on the results of present study, the low-frequency EAP could be a self-sustained mode, and the BSISO plays a substantial role in triggering the low-frequency EAP.

  13. Universal algorithm for identification of fractional Brownian motion. A case of telomere subdiffusion.

    PubMed

    Burnecki, Krzysztof; Kepten, Eldad; Janczura, Joanna; Bronshtein, Irena; Garini, Yuval; Weron, Aleksander

    2012-11-07

    We present a systematic statistical analysis of the recently measured individual trajectories of fluorescently labeled telomeres in the nucleus of living human cells. The experiments were performed in the U2OS cancer cell line. We propose an algorithm for identification of the telomere motion. By expanding the previously published data set, we are able to explore the dynamics in six time orders, a task not possible earlier. As a result, we establish a rigorous mathematical characterization of the stochastic process and identify the basic mathematical mechanisms behind the telomere motion. We find that the increments of the motion are stationary, Gaussian, ergodic, and even more chaotic--mixing. Moreover, the obtained memory parameter estimates, as well as the ensemble average mean square displacement reveal subdiffusive behavior at all time spans. All these findings statistically prove a fractional Brownian motion for the telomere trajectories, which is confirmed by a generalized p-variation test. Taking into account the biophysical nature of telomeres as monomers in the chromatin chain, we suggest polymer dynamics as a sufficient framework for their motion with no influence of other models. In addition, these results shed light on other studies of telomere motion and the alternative telomere lengthening mechanism. We hope that identification of these mechanisms will allow the development of a proper physical and biological model for telomere subdynamics. This array of tests can be easily implemented to other data sets to enable quick and accurate analysis of their statistical characteristics. Copyright © 2012 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  14. Density Functional Computations and Molecular Dynamics Simulations of the Triethylammonium Triflate Protic Ionic Liquid.

    PubMed

    Mora Cardozo, Juan F; Burankova, T; Embs, J P; Benedetto, A; Ballone, P

    2017-12-21

    Systematic molecular dynamics simulations based on an empirical force field have been carried out for samples of triethylammonium trifluoromethanesulfonate (triethylammonium triflate, [TEA][Tf]), covering a wide temperature range 200 K ≤ T ≤ 400 K and analyzing a broad set of properties, from self-diffusion and electrical conductivity to rotational relaxation and hydrogen-bond dynamics. The study is motivated by recent quasi-elastic neutron scattering and differential scanning calorimetry measurements on the same system, revealing two successive first order transitions at T ≈ 230 and 310 K (on heating), as well as an intriguing and partly unexplained variety of subdiffusive motions of the acidic proton. Simulations show a weakly discontinuous transition at T = 310 K and highlight an anomaly at T = 260 K in the rotational relaxation of ions that we identify with the simulation analogue of the experimental transition at T = 230 K. Thus, simulations help identifying the nature of the experimental transitions, confirming that the highest temperature one corresponds to melting, while the one taking place at lower T is a transition from the crystal, stable at T ≤ 260 K, to a plastic phase (260 ≤ T ≤ 310 K), in which molecules are able to rotate without diffusing. Rotations, in particular, account for the subdiffusive motion seen at intermediate T both in the experiments and in the simulation. The structure, distribution, and strength of hydrogen bonds are investigated by molecular dynamics and by density functional computations. Clustering of ions of the same sign and the effect of contamination by water at 1% wgt concentration are discussed as well.

  15. Sources of anomalous transient electric signals (ATESs) in the ULF band in the Lamia region (central Greece): electrochemical mechanisms for their generation

    NASA Astrophysics Data System (ADS)

    Pham, V.-N.; Boyer, D.; Chouliaras, G.; Savvaidis, A.; Stavrakakis, G.; Le Mouël, J.-L.

    2002-04-01

    Anomalous transient electric signals (ATESs) in the ultra low frequency (ULF) band have been often observed during magnetotelluric (MT) investigations [Nature 319 (1986) 310; Phys. Earth Planet. Int. 114 (1999) 141; Geophys. J. Int. 142 (2000) 948], but their origin was unknown until now. They have the same characteristics as the so-called seismic electric signals (SES) claimed to be earthquake precursors by the VAN group (e.g. [Tectonophysics 110 (1984) 73] and later works by this group). Our analysis suggests that the so-called SES could be of anthropic origin. Following the devastating 7 September 1999 Athens earthquake, the VAN group claimed that a SES had been recorded at LAM station (Lamia, central Greece) some days prior to the main shock and that a second SES, which might correspond to an impending even larger earthquake, had been observed after the main shock. In the 2 years after the Athens main shock, no subsequent large earthquakes have occurred near Athens. We conducted a campaign of measurement in the Lamia region in May and June 2001. The results show that ATESs, which look like SES, have several different sources: pump-stations for ground-water, high power electric lines, and factories located to the SE of Lamia city. The ATESs can be generated by two electrochemical mechanisms of metallic electrode polarization: the "galvanic cell" and the "ac electrolytic cell" which are studied by simulated field experiments and discussed in detail in Appendix A. These two mechanisms can occur over a wide range of length scales in the field. Any isolation failure in buried metallic conductors, such as electrical and telecommunication networks, oil, water and gas pipes, railways, high power electric lines, factories and so on, can produce a galvanic cell or an ac electrolytic cell, or both, which could generate, under some circumstances, an "overvoltage", the ATES. Finally, the absence of a magnetic signal has been observed during ATES and does not constitute a firm criterion for SES [Acta Geophys. Pol. 44 (1996b) 301]. Thus, great care must be taken when claiming the existence of electric precursors of seismic or volcanic events.

  16. Electrochemical, Structural and Magnetic Analysis of Electrodeposited CoCu/Cu Multilayers: Influence of Cu Layer Deposition Potential

    NASA Astrophysics Data System (ADS)

    Tekgül, Atakan; Kockar, Hakan; Kuru, Hilal; Alper, Mürsel; ÜnlÜ, C. Gökhan

    2018-03-01

    The electrochemical, structural and magnetic properties of CoCu/Cu multilayers electrodeposited at different cathode potentials were investigated from a single bath. The Cu layer deposition potentials were selected as - 0.3, V - 0.4 V, and - 0.5 V with respect to saturated calomel electrode (SCE) while the Co layer deposition potential was constant at - 1.5 V versus SCE. For the electrochemical analysis, the current-time transients were obtained. The amount of noble non-magnetic (Cu) metal materials decreased with the increase of deposition potentials due to anomalous codeposition. Further, current-time transient curves for the Co layer deposition and capacitance were calculated. In the structural analysis, the multilayers were found to be polycrystalline with both Co and Cu layers adopting the face-centered cubic structure. The (111) peak shifts towards higher angle with the increase of the deposition potentials. Also, the lattice parameters of the multilayers decrease from 0.3669 nm to 0.3610 nm with the increase of the deposition potentials from - 0.3 V to - 0.5 V, which corresponds to the bulk values of Cu and Co, respectively. The electrochemical and structural results demonstrate that the amount of Co atoms increased and the Cu atoms decreased in the layers with the increase of deposition potentials due to anomalous codeposition. For magnetic measurements, the saturation magnetizations, M_s obtained from the magnetic curves of the multilayers were obtained as 212 kA/m, 276 kA/m, and 366 kA/m with - 0.3 V, - 0.4 V, and - 0.5 V versus SCE, respectively. It is seen that the M_s values increased with the increase of the deposition potentials confirming the increase of the Co atoms and decrease of the Cu amount. The results of electrochemical and structural analysis show that the deposition potentials of non-magnetic layers plays important role on the amount of magnetic and non-magnetic materials in the layers and thus on the magnetic properties of the multilayers.

  17. Detection of anomalous signals in temporally correlated data (Invited)

    NASA Astrophysics Data System (ADS)

    Langbein, J. O.

    2010-12-01

    Detection of transient tectonic signals in data obtained from large geodetic networks requires the ability to detect signals that are both temporally and spatially coherent. In this report I will describe a modification to an existing method that estimates both the coefficients of temporally correlated noise model and an efficient filter based on the noise model. This filter, when applied to the original time-series, effectively whitens (or flattens) the power spectrum. The filtered data provide the means to calculate running averages which are then used to detect deviations from the background trends. For large networks, time-series of signal-to-noise ratio (SNR) can be easily constructed since, by filtering, each of the original time-series has been transformed into one that is closer to having a Gaussian distribution with a variance of 1.0. Anomalous intervals may be identified by counting the number of GPS sites for which the SNR exceeds a specified value. For example, during one time interval, if there were 5 out of 20 time-series with SNR>2, this would be considered anomalous; typically, one would expect at 95% confidence that there would be at least 1 out of 20 time-series with an SNR>2. For time intervals with an anomalously large number of high SNR, the spatial distribution of the SNR is mapped to identify the location of the anomalous signal(s) and their degree of spatial clustering. Estimating the filter that should be used to whiten the data requires modification of the existing methods that employ maximum likelihood estimation to determine the temporal covariance of the data. In these methods, it is assumed that the noise components in the data are a combination of white, flicker and random-walk processes and that they are derived from three different and independent sources. Instead, in this new method, the covariance matrix is constructed assuming that only one source is responsible for the noise and that source can be represented as a white-noise random-number generator convolved with a filter whose spectral properties are frequency (f) independent at its highest frequencies, 1/f at the middle frequencies, and 1/f2 at the lowest frequencies. For data sets with no gaps in their time-series, construction of covariance and inverse covariance matrices is extremely efficient. Application of the above algorithm to real data potentially involves several iterations as small, tectonic signals of interest are often indistinguishable from background noise. Consequently, simply plotting the time-series of each GPS site is used to identify the largest outliers and signals independent of their cause. Any analysis of the background noise levels must factor in these other signals while the gross outliers need to be removed.

  18. Can I solve my structure by SAD phasing? Anomalous signal in SAD phasing

    DOE PAGES

    Terwilliger, Thomas C.; Bunkóczi, Gábor; Hung, Li-Wei; ...

    2016-03-01

    A key challenge in the SAD phasing method is solving a structure when the anomalous signal-to-noise ratio is low. We present a simple theoretical framework for describing measurements of anomalous differences and the resulting useful anomalous correlation and anomalous signal in a SAD experiment. Here, the useful anomalous correlation is defined as the correlation of anomalous differences with ideal anomalous differences from the anomalous substructure. The useful anomalous correlation reflects the accuracy of the data and the absence of minor sites. The useful anomalous correlation also reflects the information available for estimating crystallographic phases once the substructure has been determined.more » In contrast, the anomalous signal (the peak height in a model-phased anomalous difference Fourier at the coordinates of atoms in the anomalous substructure) reflects the information available about each site in the substructure and is related to the ability to find the substructure. A theoretical analysis shows that the expected value of the anomalous signal is the product of the useful anomalous correlation, the square root of the ratio of the number of unique reflections in the data set to the number of sites in the substructure, and a function that decreases with increasing values of the atomic displacement factor for the atoms in the substructure. In conclusion, this means that the ability to find the substructure in a SAD experiment is increased by high data quality and by a high ratio of reflections to sites in the substructure, and is decreased by high atomic displacement factors for the substructure.« less

  19. Can I solve my structure by SAD phasing? Anomalous signal in SAD phasing.

    PubMed

    Terwilliger, Thomas C; Bunkóczi, Gábor; Hung, Li Wei; Zwart, Peter H; Smith, Janet L; Akey, David L; Adams, Paul D

    2016-03-01

    A key challenge in the SAD phasing method is solving a structure when the anomalous signal-to-noise ratio is low. A simple theoretical framework for describing measurements of anomalous differences and the resulting useful anomalous correlation and anomalous signal in a SAD experiment is presented. Here, the useful anomalous correlation is defined as the correlation of anomalous differences with ideal anomalous differences from the anomalous substructure. The useful anomalous correlation reflects the accuracy of the data and the absence of minor sites. The useful anomalous correlation also reflects the information available for estimating crystallographic phases once the substructure has been determined. In contrast, the anomalous signal (the peak height in a model-phased anomalous difference Fourier at the coordinates of atoms in the anomalous substructure) reflects the information available about each site in the substructure and is related to the ability to find the substructure. A theoretical analysis shows that the expected value of the anomalous signal is the product of the useful anomalous correlation, the square root of the ratio of the number of unique reflections in the data set to the number of sites in the substructure, and a function that decreases with increasing values of the atomic displacement factor for the atoms in the substructure. This means that the ability to find the substructure in a SAD experiment is increased by high data quality and by a high ratio of reflections to sites in the substructure, and is decreased by high atomic displacement factors for the substructure.

  20. Lateral extrusion of a thermally weakened pluton overburden (Campiglia Marittima, Tuscany)

    NASA Astrophysics Data System (ADS)

    Vezzoni, Simone; Rocchi, Sergio; Dini, Andrea

    2017-10-01

    The ascent and emplacement of magmas in the upper crust modify the local pre-existing thermal and rheological settings. Such changes have important effects in producing anomalous structures, mass extrusion, rock fracturing, and in some conditions, hydrothermal mineralizations. In the Campiglia Marittima area, detailed field mapping led to the reconstruction of a local deformation history that overlaps, chronologically and spatially, with regional extension. This local deformation was triggered at the Miocene-Pliocene boundary by the intrusion of a monzogranitic pluton beneath a carbonate sedimentary sequence. The emplacement of the pluton produced a perturbation in the rheological behaviour of the carbonate host rocks, producing transient ductile conditions in the very shallow crust. The carbonate rocks were thermally weakened and flowed laterally, accumulating downslope of the pluton roof, mainly toward the east. As the thermal anomaly was decaying, the brittle-ductile boundary moved progressively back towards the pluton, and large tension gash-shaped volumes of fractured marble were generated. These fractured volumes were exploited by rising hydrothermal fluids generating sigmoidal skarn bodies and ore shoots. This work presents the Campiglia Marittima case study as a prime example of structural interference between regional extensional structures and local, lateral mass extrusion in a transient ductile rheological regime triggered by pluton emplacement.

  1. Coupled interactions between tungsten surfaces and transient high-heat-flux deuterium plasmas

    NASA Astrophysics Data System (ADS)

    Takamura, S.; Uesugi, Y.

    2015-03-01

    Fundamental studies on the interactions between transient deuterium-plasma heat pulses and tungsten surfaces were carried out in terms of electrical, mechanical and thermal response in a compact plasma device AIT-PID (Aichi Institute of Technology-Plasma Irradiation Device). Firstly, electron-emission-induced surface-temperature increase is discussed in the surface-temperature range near tungsten's melting point, which is accomplished by controlling the sheath voltage and power transmission factor. Secondly, anomalous penetration of tungsten atomic efflux into the surrounding plasma was observed in addition to a normal layered population; it is discussed in terms of the effect of substantial tungsten influx into the deuterium plasma, which causes dissipation of plasma electron energy. Thirdly, a momentum input from pulsed plasma onto a tungsten target was observed visually. The force is estimated numerically by the accelerated ion flow to the target as well as the reaction of tungsten-vapour efflux. Finally, a discussion follows on the effects of the plasma heat pulses on the morphology of tungsten surface (originally a helium-induced ‘fuzzy’ nanostructure). A kind of bifurcated effect is obtained: melting and annealing. Open questions remain for all the phenomena observed, although sheath-voltage-dependent plasma-heat input may be a key parameter. Discussions on all these phenomena are provided by considering their implications to tokamak fusion devices.

  2. Thermodynamically consistent Langevin dynamics with spatially correlated noise predicting frictionless regime and transient attraction effect

    NASA Astrophysics Data System (ADS)

    Majka, M.; Góra, P. F.

    2016-10-01

    While the origins of temporal correlations in Langevin dynamics have been thoroughly researched, the understanding of spatially correlated noise (SCN) is rather incomplete. In particular, very little is known about the relation between friction and SCN. In this article, starting from the microscopic, deterministic model, we derive the analytical formula for the spatial correlation function in the particle-bath interactions. This expression shows that SCN is the inherent component of binary mixtures, originating from the effective (entropic) interactions. Further, employing this spatial correlation function, we postulate the thermodynamically consistent Langevin equation driven by the Gaussian SCN and calculate the adequate fluctuation-dissipation relation. The thermodynamical consistency is achieved by introducing the spatially variant friction coefficient, which can be also derived analytically. This coefficient exhibits a number of intriguing properties, e.g., the singular behavior for certain types of interactions. Eventually, we apply this new theory to the system of two charged particles in the presence of counter-ions. Such particles interact via the screened-charge Yukawa potential and the inclusion of SCN leads to the emergence of the anomalous frictionless regime. In this regime the particles can experience active propulsion leading to the transient attraction effect. This effect suggests a nonequilibrium mechanism facilitating the molecular binding of the like-charged particles.

  3. Lateral extrusion of a thermally weakened pluton overburden (Campiglia Marittima, Tuscany)

    NASA Astrophysics Data System (ADS)

    Vezzoni, Simone; Rocchi, Sergio; Dini, Andrea

    2018-06-01

    The ascent and emplacement of magmas in the upper crust modify the local pre-existing thermal and rheological settings. Such changes have important effects in producing anomalous structures, mass extrusion, rock fracturing, and in some conditions, hydrothermal mineralizations. In the Campiglia Marittima area, detailed field mapping led to the reconstruction of a local deformation history that overlaps, chronologically and spatially, with regional extension. This local deformation was triggered at the Miocene-Pliocene boundary by the intrusion of a monzogranitic pluton beneath a carbonate sedimentary sequence. The emplacement of the pluton produced a perturbation in the rheological behaviour of the carbonate host rocks, producing transient ductile conditions in the very shallow crust. The carbonate rocks were thermally weakened and flowed laterally, accumulating downslope of the pluton roof, mainly toward the east. As the thermal anomaly was decaying, the brittle-ductile boundary moved progressively back towards the pluton, and large tension gash-shaped volumes of fractured marble were generated. These fractured volumes were exploited by rising hydrothermal fluids generating sigmoidal skarn bodies and ore shoots. This work presents the Campiglia Marittima case study as a prime example of structural interference between regional extensional structures and local, lateral mass extrusion in a transient ductile rheological regime triggered by pluton emplacement.

  4. Molecular Mechanisms behind the Physiological Resistance to Intense Transient Warming in an Iconic Marine Plant

    PubMed Central

    Marín-Guirao, Lazaro; Entrambasaguas, Laura; Dattolo, Emanuela; Ruiz, Juan M.; Procaccini, Gabriele

    2017-01-01

    The endemic Mediterranean seagrass Posidonia oceanica is highly threatened by the increased frequency and intensity of heatwaves. Meadows of the species offer a unique opportunity to unravel mechanisms marine plants activate to cope transient warming, since their wide depth distribution impose divergent heat-tolerance. Understanding these mechanisms is imperative for their conservation. Shallow and deep genotypes within the same population were exposed to a simulated heatwave in mesocosms, to analyze their transcriptomic and photo-physiological responses during and after the exposure. Shallow plants, living in a more unstable thermal environment, optimized phenotype variation in response to warming. These plants showed a pre-adaptation of genes in anticipation of stress. Shallow plants also showed a stronger activation of heat-responsive genes and the exclusive activation of genes involved in epigenetic mechanisms and in molecular mechanisms that are behind their higher photosynthetic stability and respiratory acclimation. Deep plants experienced higher heat-induced damage and activated metabolic processes for obtaining extra energy from sugars and amino acids, likely to support the higher protein turnover induced by heat. In this study we identify transcriptomic mechanisms that may facilitate persistence of seagrasses to anomalous warming events and we discovered that P. oceanica plants from above and below the mean depth of the summer thermocline have differential resilience to heat. PMID:28706528

  5. Exact Results for the Nonergodicity of d -Dimensional Generalized Lévy Walks

    NASA Astrophysics Data System (ADS)

    Albers, Tony; Radons, Günter

    2018-03-01

    We provide analytical results for the ensemble-averaged and time-averaged squared displacement, and the randomness of the latter, in the full two-dimensional parameter space of the d -dimensional generalized Lévy walk introduced by Shlesinger et al. [Phys. Rev. Lett. 58, 1100 (1987), 10.1103/PhysRevLett.58.1100]. In certain regions of the parameter plane, we obtain surprising results such as the divergence of the mean-squared displacements, the divergence of the ergodicity breaking parameter despite a finite mean-squared displacement, and subdiffusion which appears superdiffusive when one only considers time averages.

  6. Time-dependent Perpendicular Transport of Energetic Particles for Different Turbulence Configurations and Parallel Transport Models

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lasuik, J.; Shalchi, A., E-mail: andreasm4@yahoo.com

    Recently, a new theory for the transport of energetic particles across a mean magnetic field was presented. Compared to other nonlinear theories the new approach has the advantage that it provides a full time-dependent description of the transport. Furthermore, a diffusion approximation is no longer part of that theory. The purpose of this paper is to combine this new approach with a time-dependent model for parallel transport and different turbulence configurations in order to explore the parameter regimes for which we get ballistic transport, compound subdiffusion, and normal Markovian diffusion.

  7. Open Heisenberg chain under boundary fields: A magnonic logic gate

    NASA Astrophysics Data System (ADS)

    Landi, Gabriel T.; Karevski, Dragi

    2015-05-01

    We study the spin transport in the quantum Heisenberg spin chain subject to boundary magnetic fields and driven out of equilibrium by Lindblad dissipators. An exact solution is given in terms of matrix product states, which allows us to calculate exactly the spin current for any chain size. It is found that the system undergoes a discontinuous spin-valve-like quantum phase transition from ballistic to subdiffusive spin current, depending on the value of the boundary fields. Thus, the chain behaves as an extremely sensitive magnonic logic gate operating with the boundary fields as the base element.

  8. IR-stimulated visible fluorescence in pink and brown diamond.

    PubMed

    Byrne, K S; Chapman, J G; Luiten, A N

    2014-03-19

    Irradiation of natural pink and brown diamond by middle-ultraviolet light (photon energy ϵ ≥ 4.1 eV ) is seen to induce anomalous fluorescence phenomena at N3 defect centres (structure N3-V). When diamonds primed in this fashion are subsequently exposed to infrared light (even with a delay of many hours), a transient burst of blue N3 fluorescence is observed. The dependence of this IR-triggered fluorescence on pump wavelength and intensity suggest that this fluorescence phenomena is intrinsically related to pink diamond photochromism. An energy transfer process between N3 defects and other defect species can account for both the UV-induced fluorescence intensity changes, and the apparent optical upconversion of IR light. From this standpoint, we consider the implications of this N3 fluorescence behaviour for the current understanding of pink diamond photochromism kinetics.

  9. Anomalous stress diffusion, Omori's law and Continuous Time Random Walk in the 2010 Efpalion aftershock sequence (Corinth rift, Greece)

    NASA Astrophysics Data System (ADS)

    Michas, Georgios; Vallianatos, Filippos; Karakostas, Vassilios; Papadimitriou, Eleftheria; Sammonds, Peter

    2014-05-01

    Efpalion aftershock sequence occurred in January 2010, when an M=5.5 earthquake was followed four days later by another strong event (M=5.4) and numerous aftershocks (Karakostas et al., 2012). This activity interrupted a 15 years period of low to moderate earthquake occurrence in Corinth rift, where the last major event was the 1995 Aigion earthquake (M=6.2). Coulomb stress analysis performed in previous studies (Karakostas et al., 2012; Sokos et al., 2012; Ganas et al., 2013) indicated that the second major event and most of the aftershocks were triggered due to stress transfer. The aftershocks production rate decays as a power-law with time according to the modified Omori law (Utsu et al., 1995) with an exponent larger than one for the first four days, while after the occurrence of the second strong event the exponent turns to unity. We consider the earthquake sequence as a point process in time and space and study its spatiotemporal evolution considering a Continuous Time Random Walk (CTRW) model with a joint probability density function of inter-event times and jumps between the successive earthquakes (Metzler and Klafter, 2000). Jump length distribution exhibits finite variance, whereas inter-event times scale as a q-generalized gamma distribution (Michas et al., 2013) with a long power-law tail. These properties are indicative of a subdiffusive process in terms of CTRW. Additionally, the mean square displacement of aftershocks is constant with time after the occurrence of the first event, while it changes to a power-law with exponent close to 0.15 after the second major event, illustrating a slow diffusive process. During the first four days aftershocks cluster around the epicentral area of the second major event, while after that and taking as a reference the second event, the aftershock zone is migrating slowly with time to the west near the epicentral area of the first event. This process is much slower from what would be expected from normal diffusion, a result that is in accordance to earthquake triggering in global scale (Huc and Main, 2003) and aftershocks diffusion in California (Helmstetter et al., 2003). While other mechanisms may be plausible, the results indicate that anomalous stress transfer due to the occurrence of the two major events control the migration of the aftershock activity, activating different fault segments and having strong implications for the seismic hazard of the area. Acknowledgments. G. Michas wishes to acknowledge the partial financial support from the Greek State Scholarships Foundation (IKY). This work has been accomplished in the framework of the postgraduate program and co-funded through the action "Program for scholarships provision I.K.Y. through the procedure of personal evaluation for the 2011-2012 academic year" from resources of the educational program "Education and Life Learning" of the European Social Register and NSRF 2007- 2013. References Ganas, A., Chousianitis, K., Batsi, E., Kolligri, M., Agalos, A., Chouliaras, G., Makropoulos, K. (2013). The January 2010 Efpalion earthquakes (Gulf of Corinth, central Greece): Earthquake interactions and blind normal faulting. J. of Seism., 17(2), 465-484. Helmstetter, A., Ouillon, G., Sornette, D. (2003). Are aftershocks of large California earthquakes diffusing? J. of Geophys. Res. B, 108(10), 2483. Huc, M., Main, I. G. (2003). Anomalous stress diffusion in earthquake triggering: Correlation length, time dependence, and directionality. J. of Geophys. Res. B, 108(7), 2324. Karakostas, V., Karagianni, E., Paradisopoulou, P. (2012). Space-time analysis, faulting and triggering of the 2010 earthquake doublet in western Corinth gulf. Nat.Haz., 63(2), 1181-1202. Metzler, R., Klafter, J. (2000). The random walk's guide to anomalous diffusion: a fractional dynamics approach. Physics Reports, 339, 1-77. Michas, G., Vallianatos, F., Sammonds, P. (2013). Non-extensivity and long-range correlations in the earthquake activity at the West Corinth rift (Greece). Nonlin. Processes Geophys., 20, 713-724. Sokos, E., Zahradník, J., Kiratzi, A., Janský, J., Gallovič, F., Novotny, O., Kostelecký, J., Serpetsidaki, A., Tselentis, G.-A. (2012). The January 2010 Efpalio earthquake sequence in the western Corinth gulf (Greece). Tectonophysics, 530-531, 299-309. Utsu, T., Y. Ogata, Matsu'ura R. S. (1995). The centenary of the Omori formula for a decay law of aftershock activity. J. Phys. Earth, 43, 1- 33.

  10. Can I solve my structure by SAD phasing? Planning an experiment, scaling data and evaluating the useful anomalous correlation and anomalous signal.

    PubMed

    Terwilliger, Thomas C; Bunkóczi, Gábor; Hung, Li Wei; Zwart, Peter H; Smith, Janet L; Akey, David L; Adams, Paul D

    2016-03-01

    A key challenge in the SAD phasing method is solving a structure when the anomalous signal-to-noise ratio is low. Here, algorithms and tools for evaluating and optimizing the useful anomalous correlation and the anomalous signal in a SAD experiment are described. A simple theoretical framework [Terwilliger et al. (2016), Acta Cryst. D72, 346-358] is used to develop methods for planning a SAD experiment, scaling SAD data sets and estimating the useful anomalous correlation and anomalous signal in a SAD data set. The phenix.plan_sad_experiment tool uses a database of solved and unsolved SAD data sets and the expected characteristics of a SAD data set to estimate the probability that the anomalous substructure will be found in the SAD experiment and the expected map quality that would be obtained if the substructure were found. The phenix.scale_and_merge tool scales unmerged SAD data from one or more crystals using local scaling and optimizes the anomalous signal by identifying the systematic differences among data sets, and the phenix.anomalous_signal tool estimates the useful anomalous correlation and anomalous signal after collecting SAD data and estimates the probability that the data set can be solved and the likely figure of merit of phasing.

  11. Can I solve my structure by SAD phasing? Planning an experiment, scaling data and evaluating the useful anomalous correlation and anomalous signal

    DOE PAGES

    Terwilliger, Thomas C.; Bunkóczi, Gábor; Hung, Li-Wei; ...

    2016-03-01

    A key challenge in the SAD phasing method is solving a structure when the anomalous signal-to-noise ratio is low. Here, we describe algorithms and tools for evaluating and optimizing the useful anomalous correlation and the anomalous signal in a SAD experiment. A simple theoretical framework [Terwilliger et al.(2016),Acta Cryst.D72, 346–358] is used to develop methods for planning a SAD experiment, scaling SAD data sets and estimating the useful anomalous correlation and anomalous signal in a SAD data set. Thephenix.plan_sad_experimenttool uses a database of solved and unsolved SAD data sets and the expected characteristics of a SAD data set to estimatemore » the probability that the anomalous substructure will be found in the SAD experiment and the expected map quality that would be obtained if the substructure were found. Thephenix.scale_and_mergetool scales unmerged SAD data from one or more crystals using local scaling and optimizes the anomalous signal by identifying the systematic differences among data sets, and thephenix.anomalous_signaltool estimates the useful anomalous correlation and anomalous signal after collecting SAD data and estimates the probability that the data set can be solved and the likely figure of merit of phasing.« less

  12. Can I solve my structure by SAD phasing? Planning an experiment, scaling data and evaluating the useful anomalous correlation and anomalous signal

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Terwilliger, Thomas C.; Bunkóczi, Gábor; Hung, Li-Wei

    A key challenge in the SAD phasing method is solving a structure when the anomalous signal-to-noise ratio is low. Here, we describe algorithms and tools for evaluating and optimizing the useful anomalous correlation and the anomalous signal in a SAD experiment. A simple theoretical framework [Terwilliger et al.(2016),Acta Cryst.D72, 346–358] is used to develop methods for planning a SAD experiment, scaling SAD data sets and estimating the useful anomalous correlation and anomalous signal in a SAD data set. Thephenix.plan_sad_experimenttool uses a database of solved and unsolved SAD data sets and the expected characteristics of a SAD data set to estimatemore » the probability that the anomalous substructure will be found in the SAD experiment and the expected map quality that would be obtained if the substructure were found. Thephenix.scale_and_mergetool scales unmerged SAD data from one or more crystals using local scaling and optimizes the anomalous signal by identifying the systematic differences among data sets, and thephenix.anomalous_signaltool estimates the useful anomalous correlation and anomalous signal after collecting SAD data and estimates the probability that the data set can be solved and the likely figure of merit of phasing.« less

  13. Complexity and anomalous diffusion of the Florina (Greece) microseismic activity associated with CO2 emissions

    NASA Astrophysics Data System (ADS)

    Michas, Georgios; Vallianatos, Filippos

    2017-04-01

    It has long been recognized that the diffusion of pressurized fluids in the Earth's crust can induce earthquakes. Characteristic cases can be drawn from earthquake swarm sequences associated with volcanic activity, oil and gas injections and extractions and CO2 emissions in the crust. Such sequences are typically characterized by strong variations and clustering effects in time and space and can neither be described by a dominant earthquake nor by any simple scaling relation, as the Omori scaling known for aftershock sequences. In 2013-2014 such a sequence occurred in northern Greece, in the area of Florina and has been associated with CO2 gases emissions through the fault and fracture network below the Florina basin (Mesimeri et al., 2017). A detailed microseismic analysis reveals the structure of the seismic cloud that is distributed in two clusters, the first of a N-S direction dipping to the north and the second of an E-W direction and almost vertical, gently dipping to the south. Furthermore, the two clusters present distinct periods of activation, which may be associated with different phases of CO2 emissions. The spatiotemporal properties of the earthquake activity inside the two clusters indicate correlated sequences in time and space, with asymptotic power-law distributions of the time and distance intervals between their successive events (e.g., Vallianatos et al., 2016). Moreover, the mean squared displacement of the earthquake activity with time for the two clusters indicate the slow migration of microseismicity. The latter process corresponds to slow sub-diffusion inside the fault segments, which may act as pathways for the migration of CO2 gases towards the surface. References Mesimeri, M., Karakostas, V., Papadimitriou, E., Tsaklidis, G., Tsapanos, T., 2017. Detailed microseismicity study in the area of Florina (Greece): Evidence for fluid driven seismicity. Tectonophysics, 694, 424-435. Vallianatos F., Papadakis G., Michas G., 2016. Generalized statistical mechanics approaches to earthquakes and tectonics. Proc. R. Soc. A, 472, 20160497. Acknowledgements G. Michas acknowledges financial support from an AXA Research Fund postdoctoral grant.

  14. Aging underdamped scaled Brownian motion: Ensemble- and time-averaged particle displacements, nonergodicity, and the failure of the overdamping approximation.

    PubMed

    Safdari, Hadiseh; Cherstvy, Andrey G; Chechkin, Aleksei V; Bodrova, Anna; Metzler, Ralf

    2017-01-01

    We investigate both analytically and by computer simulations the ensemble- and time-averaged, nonergodic, and aging properties of massive particles diffusing in a medium with a time dependent diffusivity. We call this stochastic diffusion process the (aging) underdamped scaled Brownian motion (UDSBM). We demonstrate how the mean squared displacement (MSD) and the time-averaged MSD of UDSBM are affected by the inertial term in the Langevin equation, both at short, intermediate, and even long diffusion times. In particular, we quantify the ballistic regime for the MSD and the time-averaged MSD as well as the spread of individual time-averaged MSD trajectories. One of the main effects we observe is that, both for the MSD and the time-averaged MSD, for superdiffusive UDSBM the ballistic regime is much shorter than for ordinary Brownian motion. In contrast, for subdiffusive UDSBM, the ballistic region extends to much longer diffusion times. Therefore, particular care needs to be taken under what conditions the overdamped limit indeed provides a correct description, even in the long time limit. We also analyze to what extent ergodicity in the Boltzmann-Khinchin sense in this nonstationary system is broken, both for subdiffusive and superdiffusive UDSBM. Finally, the limiting case of ultraslow UDSBM is considered, with a mixed logarithmic and power-law dependence of the ensemble- and time-averaged MSDs of the particles. In the limit of strong aging, remarkably, the ordinary UDSBM and the ultraslow UDSBM behave similarly in the short time ballistic limit. The approaches developed here open ways for considering other stochastic processes under physically important conditions when a finite particle mass and aging in the system cannot be neglected.

  15. Aging underdamped scaled Brownian motion: Ensemble- and time-averaged particle displacements, nonergodicity, and the failure of the overdamping approximation

    NASA Astrophysics Data System (ADS)

    Safdari, Hadiseh; Cherstvy, Andrey G.; Chechkin, Aleksei V.; Bodrova, Anna; Metzler, Ralf

    2017-01-01

    We investigate both analytically and by computer simulations the ensemble- and time-averaged, nonergodic, and aging properties of massive particles diffusing in a medium with a time dependent diffusivity. We call this stochastic diffusion process the (aging) underdamped scaled Brownian motion (UDSBM). We demonstrate how the mean squared displacement (MSD) and the time-averaged MSD of UDSBM are affected by the inertial term in the Langevin equation, both at short, intermediate, and even long diffusion times. In particular, we quantify the ballistic regime for the MSD and the time-averaged MSD as well as the spread of individual time-averaged MSD trajectories. One of the main effects we observe is that, both for the MSD and the time-averaged MSD, for superdiffusive UDSBM the ballistic regime is much shorter than for ordinary Brownian motion. In contrast, for subdiffusive UDSBM, the ballistic region extends to much longer diffusion times. Therefore, particular care needs to be taken under what conditions the overdamped limit indeed provides a correct description, even in the long time limit. We also analyze to what extent ergodicity in the Boltzmann-Khinchin sense in this nonstationary system is broken, both for subdiffusive and superdiffusive UDSBM. Finally, the limiting case of ultraslow UDSBM is considered, with a mixed logarithmic and power-law dependence of the ensemble- and time-averaged MSDs of the particles. In the limit of strong aging, remarkably, the ordinary UDSBM and the ultraslow UDSBM behave similarly in the short time ballistic limit. The approaches developed here open ways for considering other stochastic processes under physically important conditions when a finite particle mass and aging in the system cannot be neglected.

  16. Observed formation of easterly waves over northeast Africa

    NASA Astrophysics Data System (ADS)

    Jury, Mark R.

    2018-06-01

    This study explores the thermodynamic and kinematic features of easterly waves over northeast Africa in July-September season 2005-2015. A daily African easterly wave (AEW) index is formulated from transient satellite rainfall and reanalysis vorticity, and the ten most intense cases are studied by composite analysis. Surface moisture is advected from central Africa towards the Red Sea during AEW formation. The anomalous 600 hPa wind circulation is comprized of a cyclonic-south anticyclonic-north rotor pair and accentuated easterly jet along 17N. Composite convection is initiated over Ethiopia and subsequently intensifies following interaction with a zonal circulation located downstream. Composite AEW temperature anomalies reveal a cool lower-warm upper layer heating profile. 2-8 day variance of satellite OLR reaches a maximum over the southern Arabian Peninsula, suggesting an upstream role for surface heating and the Somali Jet. The large scale environment is analyzed by regression of the AEW index onto daily fields of rainfall, surface air pressure and temperature in July-September season ( N = 1004). The rainfall regression reflects a westward propagating AEW wave-train of higher values on 13N and lower values on 7N with a longitude spacing of 25°. The air pressure and temperature regression features a N-S dipole indicating an anomalous northward ITCZ. A low pressure signal west of the Maritime Continent coupled with a warm zone across the South Indian Ocean coincides with AEW formation over the eastern Sahel.

  17. An index of anomalous convective instability to detect tornadic and hail storms

    NASA Astrophysics Data System (ADS)

    Qian, Weihong; Leung, Jeremy Cheuk-Hin; Luo, Weimeng; Du, Jun; Gao, Jidong

    2017-12-01

    In this article, the synoptic-scale spatial structures for raising tornadic and hail storms are compared by analyzing the total and anomalous variable fields from the troposphere to the stratosphere. 15 cases of tornado outbreaks and 20 cases of hail storms that occurred in the central United States during 1980-2011 were studied. The anomalous temperature-height field shows that a tornadic or hail storm usually occurs at the boundary of anomalous warm and cold air masses horizontally in the troposphere. In one side, an anomalous warm air mass in the mid-low troposphere and an anomalous cold air mass in the stratosphere are vertically separated by a positive center of height anomalies at the upper troposphere. In another side, an opposite vertical pattern shows that an anomalous cold air mass in the mid-low troposphere and an anomalous warm air mass in the stratosphere are separated by a negative center of height anomalies at the upper troposphere. Therefore, two pairs of adjacent anomalous warm/cold centers and one pair of anomalous high/low centers combining together form a major tornadic or hail storm paradigm, which can be physically considered as the storage of anomalous potential energy (APE) to generate severe weather. To quantitatively measure the APE, we define an index of anomalous convective instability (ACI) which is a difference of integrating temperature anomalies based on two vertically opposite anomalous air masses. The APE transformation to anomalous kinetic energy, which reduces horizontal and vertical gradients of temperature anomalies, produces anomalous rising and sinking flows in the lower-layer anomalous warm and cold air mass sides, respectively. The intensity of ACI index for tornadic storm cases is 1.5 times larger than that of hail storm cases in average. Thus, this expression of anomalous variables is better than total variables used in the traditional synoptic chart and the ACI index is better than other indices to detect potential tornadic and hail storms in order to understand the environmental conditions affecting severe weather in analytical and model output datasets.

  18. Spatiotemporal evolution of a transient slip event on the San Andreas fault near Parkfield, California

    USGS Publications Warehouse

    Murray, J.R.; Segall, P.

    2005-01-01

    In 1993 several baselines of the two-color electronic distance meter (EDM) network at Parkfield, California, deviated from their long-term rates, coincident with anomalous observations from nearby strain meters and a creep meter, as well as an increase in microseismicity. Between October 1992 and December 1994, three M ??? 4.5 earthquakes occurred beneath Middle Mountain, near the hypocenter of the 1934 and 1966 Parkfield M6 events. We analyzed the two-color EDM data using a Kalman-filtering based technique to image the spatiotemporal evolution of slip on the fault at Parkfield between the mid-1980s and 2003. This method accounts for localized random walk motion of the geodetic monuments and a prominent seasonal signal that affects many baselines. We find that a slip rate increase occurred between January 1993 and July 1996 on the upper 8 km of the fault near Middle Mountain. The peak estimated slip rate during this time was 49 mm/yr, which exceeds the long-term geologic rate of ???35 mm/yr. The slip rate evolution appears episodic, with an initial modest increase after the M4.3 earthquake and a much larger jump following the shallower M4.7 event in December 1994. This temporal correlation between inferred slip and seismicity suggests that the moderate earthquakes triggered the aseismic fault slip. The EDM data cannot resolve whether transient slip propagated across the nucleation zone of the 1934 and 1966 M6 Parkfield earthquakes. However, transient slip and its associated stress release in the hypocentral area of previous Parkfield events is consistent with the nucleation of the 2004 M6 Parkfield earthquake elsewhere on the fault. Copyright 2005 by the American Geophysical Union.

  19. Unusual Black Hole Binary LMC X-3: A Transient High-mass X-Ray Binary That Is Almost Always On?

    NASA Astrophysics Data System (ADS)

    Torpin, Trevor J.; Boyd, Patricia T.; Smale, Alan P.; Valencic, Lynne A.

    2017-11-01

    We have analyzed a rich, multimission, multiwavelength data set from the black hole X-ray binary (BHXB) LMC X-3, covering a new anomalous low state (ALS), during which the source flux falls to an unprecedentedly low and barely detectable level, and a more normal low state. Simultaneous X-ray and UV/optical monitoring data from Swift are combined with pointed observations from the Rossi X-ray Timing Explorer (RXTE) and X-ray Multi-Mirror Mission (XMM-Newton) and light curves from the Monitor of All-Sky X-ray Image (MAXI) instrument to compare the source characteristics during the ALS with those seen during the normal low state. An XMM-Newton spectrum obtained during the ALS can be modeled using an absorbed power law with {{Γ }}=1.41+/- 0.65 and a luminosity of 7.97× {10}33 erg s-1 (0.6-5 keV). The Swift X-ray and UV light curves indicate an X-ray lag of ˜8 days as LMC X-3 abruptly exits the ALS, suggesting that changes in the mass accretion rate from the donor drive the X-ray lag. The normal low state displays an asymmetric profile in which the exit occurs more quickly than the entry, with minimum X-ray flux a factor of ˜4300 brighter than during the ALS. The UV brightness of LMC X-3 in the ALS is also fainter and less variable than during normal low states. The existence of repeated ALSs in LMC X-3, as well as a comparison with other BHXBs, implies that it is very close to the transient/persistent X-ray source dividing line. We conclude that LMC X-3 is a transient source that is almost always “on.”

  20. Unusual Black Hole Binary LMC X-3: A Transient High-Mass X-Ray Binary That Is Almost Always On?

    NASA Technical Reports Server (NTRS)

    Torpin, Trevor J.; Boyd, Patricia T.; Smale, Alan P.; Valencic, Lynne A.

    2017-01-01

    We have analyzed a rich, multimission, multiwavelength data set from the black hole X-ray binary (BHXB) LMC X-3, covering a new anomalous low state (ALS), during which the source flux falls to an unprecedentedly low and barely detectable level, and a more normal low state. Simultaneous X-ray and UV/optical monitoring data from Swift are combined with pointed observations from the Rossi X-ray Timing Explorer (RXTE) and X-ray Multi- Mirror Mission (XMM-Newton) and light curves from the Monitor of All-Sky X-ray Image (MAXI) instrument to compare the source characteristics during the ALS with those seen during the normal low state. An XMM-Newton spectrum obtained during the ALS can be modeled using an absorbed power law with Gamma = 1.41‚+/- 0.65 and a luminosity of 7.97 x 10(exp 33) erg/s (0.6-5 keV). The Swift X-ray and UV light curves indicate an X-ray lag of approx. 8 days as LMC X-3 abruptly exits the ALS, suggesting that changes in the mass accretion rate from the donor drive the X-ray lag. The normal low state displays an asymmetric profile in which the exit occurs more quickly than the entry, with minimum X-ray flux a factor of approx. 4300 brighter than during the ALS. The UV brightness of LMC X-3 in the ALS is also fainter and less variable than during normal low states. The existence of repeated ALSs in LMC X-3, as well as a comparison with other BHXBs, implies that it is very close to the transient/persistent X-ray source dividing line. We conclude that LMC X-3 is a transient source that is almost always "on."

  1. Analysis of Complex Valve and Feed Systems

    NASA Technical Reports Server (NTRS)

    Ahuja, Vineet; Hosangadi, Ashvin; Shipman, Jeremy; Cavallo, Peter; Dash, Sanford

    2007-01-01

    A numerical framework for analysis of complex valve systems supports testing of propulsive systems by simulating key valve and control system components in the test loop. In particular, it is designed to enhance the analysis capability in terms of identifying system transients and quantifying the valve response to these transients. This system has analysis capability for simulating valve motion in complex systems operating in diverse flow regimes ranging from compressible gases to cryogenic liquids. A key feature is the hybrid, unstructured framework with sub-models for grid movement and phase change including cryogenic cavitations. The multi-element unstructured framework offers improved predictions of valve performance characteristics under steady conditions for structurally complex valves such as pressure regulator valve. Unsteady simulations of valve motion using this computational approach have been carried out for various valves in operation at Stennis Space Center such as the split-body valve and the 10-in. (approx.25.4-cm) LOX (liquid oxygen) valve and the 4-in. (approx.10 cm) Y-pattern valve (liquid nitrogen). Such simulations make use of variable grid topologies, thereby permitting solution accuracy and resolving important flow physics in the seat region of the moving valve. An advantage to this software includes possible reduction in testing costs incurred due to disruptions relating to unexpected flow transients or functioning of valve/flow control systems. Prediction of the flow anomalies leading to system vibrations, flow resonance, and valve stall can help in valve scheduling and significantly reduce the need for activation tests. This framework has been evaluated for its ability to predict performance metrics like flow coefficient for cavitating venturis and valve coefficient curves, and could be a valuable tool in predicting and understanding anomalous behavior of system components at rocket propulsion testing and design sites.

  2. Areas of Weakly Anomalous to Anomalous Surface Temperature in Alamosa and Saguache Counties, Colorado, as Identified from ASTER Thermal Data

    DOE Data Explorer

    Khalid Hussein

    2012-02-01

    This "Weakly Anomalous to Anomalous Surface Temperature" dataset differs from the "Anomalous Surface Temperature" dataset for this county (another remotely sensed CIRES product) by showing areas of modeled temperatures between 1o and 2o above the mean, as opposed to the greater than 2o temperatures contained in the "Anomalous Surface Temperature" dataset. Note: 'o' is used in this description to represent lowercase sigma

  3. Can I solve my structure by SAD phasing? Planning an experiment, scaling data and evaluating the useful anomalous correlation and anomalous signal

    PubMed Central

    Terwilliger, Thomas C.; Bunkóczi, Gábor; Hung, Li-Wei; Zwart, Peter H.; Smith, Janet L.; Akey, David L.; Adams, Paul D.

    2016-01-01

    A key challenge in the SAD phasing method is solving a structure when the anomalous signal-to-noise ratio is low. Here, algorithms and tools for evaluating and optimizing the useful anomalous correlation and the anomalous signal in a SAD experiment are described. A simple theoretical framework [Terwilliger et al. (2016 ▸), Acta Cryst. D72, 346–358] is used to develop methods for planning a SAD experiment, scaling SAD data sets and estimating the useful anomalous correlation and anomalous signal in a SAD data set. The phenix.plan_sad_experiment tool uses a database of solved and unsolved SAD data sets and the expected characteristics of a SAD data set to estimate the probability that the anomalous substructure will be found in the SAD experiment and the expected map quality that would be obtained if the substructure were found. The phenix.scale_and_merge tool scales unmerged SAD data from one or more crystals using local scaling and optimizes the anomalous signal by identifying the systematic differences among data sets, and the phenix.anomalous_signal tool estimates the useful anomalous correlation and anomalous signal after collecting SAD data and estimates the probability that the data set can be solved and the likely figure of merit of phasing. PMID:26960123

  4. Recovery Characteristics of Anomalous Stress-Induced Leakage Current of 5.6 nm Oxide Films

    NASA Astrophysics Data System (ADS)

    Inatsuka, Takuya; Kumagai, Yuki; Kuroda, Rihito; Teramoto, Akinobu; Sugawa, Shigetoshi; Ohmi, Tadahiro

    2012-04-01

    Anomalous stress-induced leakage current (SILC), which has a much larger current density than average SILC, causes severe bit error in flash memories. To suppress anomalous SILC, detailed evaluations are strongly required. We evaluate the characteristics of anomalous SILC of 5.6 nm oxide films using a fabricated array test pattern, and recovery characteristics are observed. Some characteristics of typical anomalous cells in the time domain are measured, and the recovery characteristics of average and anomalous SILCs are examined. Some of the anomalous cells have random telegraph signals (RTSs) of gate leakage current, which are characterized as discrete and random switching phenomena. The dependence of RTSs on the applied electric field is investigated, and the recovery tendency of anomalous SILC with and without RTSs are also discussed.

  5. Relationship between the anomalous diffusion and the fractal dimension of the environment

    NASA Astrophysics Data System (ADS)

    Zhokh, Alexey; Trypolskyi, Andrey; Strizhak, Peter

    2018-03-01

    In this letter, we provide an experimental study highlighting a relation between the anomalous diffusion and the fractal dimension of the environment using the methanol anomalous transport through the porous solid pellets with various pores geometries and different chemical compositions. The anomalous diffusion exponent was derived from the non-integer order of the time-fractional diffusion equation that describes the methanol anomalous transport through the solid media. The surface fractal dimension was estimated from the nitrogen adsorption isotherms using the Frenkel-Halsey-Hill method. Our study shows that decreasing the fractal dimension leads to increasing the anomalous diffusion exponent, whereas the anomalous diffusion constant is independent on the fractal dimension. We show that the obtained results are in a good agreement with the anomalous diffusion model on a fractal mesh.

  6. Fractional Diffusion Equations and Anomalous Diffusion

    NASA Astrophysics Data System (ADS)

    Evangelista, Luiz Roberto; Kaminski Lenzi, Ervin

    2018-01-01

    Preface; 1. Mathematical preliminaries; 2. A survey of the fractional calculus; 3. From normal to anomalous diffusion; 4. Fractional diffusion equations: elementary applications; 5. Fractional diffusion equations: surface effects; 6. Fractional nonlinear diffusion equation; 7. Anomalous diffusion: anisotropic case; 8. Fractional Schrödinger equations; 9. Anomalous diffusion and impedance spectroscopy; 10. The Poisson–Nernst–Planck anomalous (PNPA) models; References; Index.

  7. Lévy/Anomalous Diffusion as a Mean-Field Theory for 3D Cloud Effects in Shortwave Radiative Transfer: Empirical Support, New Analytical Formulation, and Impact on Atmospheric Absorption

    NASA Astrophysics Data System (ADS)

    Buldyrev, S.; Davis, A.; Marshak, A.; Stanley, H. E.

    2001-12-01

    Two-stream radiation transport models, as used in all current GCM parameterization schemes, are mathematically equivalent to ``standard'' diffusion theory where the physical picture is a slow propagation of the diffuse radiation by Gaussian random walks. The space/time spread (technically, the Green function) of this diffusion process is described exactly by a Gaussian distribution; from the statistical physics viewpoint, this follows from the convergence of the sum of many (rescaled) steps between scattering events with a finite variance. This Gaussian picture follows directly from first principles (the radiative transfer equation) under the assumptions of horizontal uniformity and large optical depth, i.e., there is a homogeneous plane-parallel cloud somewhere in the column. The first-order effect of 3D variability of cloudiness, the main source of scattering, is to perturb the distribution of single steps between scatterings which, modulo the ``1-g'' rescaling, can be assumed effectively isotropic. The most natural generalization of the Gaussian distribution is the 1-parameter family of symmetric Lévy-stable distributions because the sum of many zero-mean random variables with infinite variance, but finite moments of order q < α (0 < α < 2), converge to them. It has been shown on heuristic grounds that for these Lévy-based random walks the typical number of scatterings is now (1-g)τ α for transmitted light. The appearance of a non-rational exponent is why this is referred to as ``anomalous'' diffusion. Note that standard/Gaussian diffusion is retrieved in the limit α = 2-. Lévy transport theory has been successfully used in the statistical physics literature to investigate a wide variety of systems with strongly nonlinear dynamics; these applications range from random advection in turbulent fluids to the erratic behavior of financial time-series and, most recently, self-regulating ecological systems. We will briefly survey the state-of-the-art observations that offer compelling empirical support for the Lévy/anomalous diffusion model in atmospheric radiation: (1) high-resolution spectroscopy of differential absorption in the O2 A-band from ground; (2) temporal transient records of lightning strokes transmitted through clouds to a sensitive detector in space; and (3) the Gamma-distributions of optical depths derived from Landsat cloud scenes at 30-m resolution. We will then introduce a rigorous analytical formulation of Lévy/anomalous transport through finite media based on fractional derivatives and Sonin calculus. A remarkable result from this new theoretical development is an extremal property of the α = 1+ case (divergent mean-free-path), as is observed in the cloudy atmosphere. Finally, we will discuss the implications of anomalous transport theory for bulk 3D effects on the current enhanced absorption problem as well as its role as the basis of a next-generation GCM radiation parameterization.

  8. The STD/MHD codes - Comparison of analyses with experiments at AEDC/HPDE, Reynolds Metal Co., and Hercules, Inc. [for MHD generator flows

    NASA Technical Reports Server (NTRS)

    Vetter, A. A.; Maxwell, C. D.; Swean, T. F., Jr.; Demetriades, S. T.; Oliver, D. A.; Bangerter, C. D.

    1981-01-01

    Data from sufficiently well-instrumented, short-duration experiments at AEDC/HPDE, Reynolds Metal Co., and Hercules, Inc., are compared to analyses with multidimensional and time-dependent simulations with the STD/MHD computer codes. These analyses reveal detailed features of major transient events, severe loss mechanisms, and anomalous MHD behavior. In particular, these analyses predicted higher-than-design voltage drops, Hall voltage overshoots, and asymmetric voltage drops before the experimental data were available. The predictions obtained with these analyses are in excellent agreement with the experimental data and the failure predictions are consistent with the experiments. The design of large, high-interaction or advanced MHD experiments will require application of sophisticated, detailed and comprehensive computational procedures in order to account for the critical mechanisms which led to the observed behavior in these experiments.

  9. Free-beam soliton self-compression in air

    NASA Astrophysics Data System (ADS)

    Voronin, A. A.; Mitrofanov, A. V.; Sidorov-Biryukov, D. A.; Fedotov, A. B.; Pugžlys, A.; Panchenko, V. Ya; Shumakova, V.; Ališauskas, S.; Baltuška, A.; Zheltikov, A. M.

    2018-02-01

    We identify a physical scenario whereby soliton transients generated in freely propagating laser beams within the regions of anomalous dispersion in air can be compressed as a part of their free-beam spatiotemporal evolution to yield few-cycle mid- and long-wavelength-infrared field waveforms, whose peak power is substantially higher than the peak power of the input pulses. We show that this free-beam soliton self-compression scenario does not require ionization or laser-induced filamentation, enabling high-throughput self-compression of mid- and long-wavelength-infrared laser pulses within a broad range of peak powers from tens of gigawatts up to the terawatt level. We also demonstrate that this method of pulse compression can be extended to long-range propagation, providing self-compression of high-peak-power laser pulses in atmospheric air within propagation ranges as long as hundreds of meters, suggesting new ways towards longer-range standoff detection and remote sensing.

  10. Rapid ray motions in barium plasma clouds and auroras

    NASA Technical Reports Server (NTRS)

    Wescott, E. M.; Hallinan, T. J.; Stenbaek-Nielsen, H. C.; Swift, D. W.; Wallis, D. D.

    1993-01-01

    On two evenings in 1968, anomalous field-aligned brightenings or emission enhancements of up to 3X were observed to move rapidly through three different Ba(+) clouds over Andoya, Norway. Similar effects were observed in Ba(+) clouds released from rockets launched from Poker Flat, Alaska, on March 21, 1973 and on March 22, 1980. On these occasions, auroras on or near the Ba(+) L shell also exhibited active rapid ray motions, which prompts the assumption that the two phenomena are related and the expectation that an explanation of the rapid ray motions in the Ba(+) clouds would lead to a better understanding of the physics of auroral ray motions and the auroral atmosphere. Seven possible mechanisms to produce the observed moving emission enhancements are discussed. The observations provide strong evidence for the existence of transient electric fields of order 100 mV/m at altitudes as low as 200 km during active aurora with rapid ray motions.

  11. The CFS-PML in numerical simulation of ATEM

    NASA Astrophysics Data System (ADS)

    Zhao, Xuejiao; Ji, Yanju; Qiu, Shuo; Guan, Shanshan; Wu, Yanqi

    2017-01-01

    In the simulation of airborne transient electromagnetic method (ATEM) in time-domain, the truncated boundary reflection can bring a big error to the results. The complex frequency shifted perfectly matched layer (CFS-PML) absorbing boundary condition has been proved to have a better absorption of low frequency incident wave and can reduce the late reflection greatly. In this paper, we apply the CFS-PML to three-dimensional numerical simulation of ATEM in time-domain to achieve a high precision .The expression of divergence equation in CFS-PML is confirmed and its explicit iteration format based on the finite difference method and the recursive convolution technique is deduced. Finally, we use the uniformity half space model and the anomalous model to test the validity of this method. Results show that the CFS-PML can reduce the average relative error to 2.87% and increase the accuracy of the anomaly recognition.

  12. Fivefold confinement time increase in the Madison Symmetric Torus using inductive poloidal current drive

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stoneking, M.R.; Lanier, N.E.; Prager, S.C.

    1996-12-01

    Current profile control is employed in the Madison Symmetric Torus reversed field pinch to reduce the magnetic fluctuations responsible for anomalous transport. An inductive poloidal electric field pulse is applied in the sense to flatten the parallel current profile, reducing the dynamo fluctuation amplitude required to sustain the equilibrium. This technique demonstrates a substantial reduction in fluctuation amplitude (as much as 50%), and improvement in energy confinement (from 1 ms to 5 ms); a record low fluctuation (0.8%) and record high temperature (615 eV) for this device were observed simultaneously during current drive experiments. Plasma beta increases by 50% andmore » the Ohmic input power is three times lower. Particle confinement improves and plasma impurity contamination is reduced. The results of the transient current drive experiments provide motivation for continuing development of steady-state current profile control strategies for the reversed field pinch.« less

  13. Strengthening mechanisms, creep, and fatigue processes in dispersion-hardened niobium alloy. Final scientific report, 1 Feb 89-31 Jan 92

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mukherjee, A.K.; Gibeling, J.C.

    The creep and fatigue properties of pure Nb and Nb-l%Zr alloy were investigated. A model was developed based on the migration of subgrain boundary that can explain the anomalous primary creep transients found in Nb-l%Zr alloy, due to coarsening of subgrain structure. TEM investigations confirmed that such subgrain coarsening occurs during primary creep of Nb-l%Zr. Baseline low cycle fatigue studies of Nb and Nb-l%Zr were completed. Cyclic hardening is observed and there is a microplastic plateau in Nb. The Nb-1%Zr is stronger in cyclic deformation than Nb, with little influence of strain rate. The deformation in the alloy at bothmore » high and low strain rates is controlled by the interaction between gliding edge dislocation and solute atoms.« less

  14. Automated reduction of sub-millimetre single-dish heterodyne data from the James Clerk Maxwell Telescope using ORAC-DR

    NASA Astrophysics Data System (ADS)

    Jenness, Tim; Currie, Malcolm J.; Tilanus, Remo P. J.; Cavanagh, Brad; Berry, David S.; Leech, Jamie; Rizzi, Luca

    2015-10-01

    With the advent of modern multidetector heterodyne instruments that can result in observations generating thousands of spectra per minute it is no longer feasible to reduce these data as individual spectra. We describe the automated data reduction procedure used to generate baselined data cubes from heterodyne data obtained at the James Clerk Maxwell Telescope (JCMT). The system can automatically detect baseline regions in spectra and automatically determine regridding parameters, all without input from a user. Additionally, it can detect and remove spectra suffering from transient interference effects or anomalous baselines. The pipeline is written as a set of recipes using the ORAC-DR pipeline environment with the algorithmic code using Starlink software packages and infrastructure. The algorithms presented here can be applied to other heterodyne array instruments and have been applied to data from historical JCMT heterodyne instrumentation.

  15. Individual electron and hole localization in submonolayer InN quantum sheets embedded in GaN

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Feix, F., E-mail: feix@pdi-berlin.de; Flissikowski, T.; Chèze, C.

    2016-07-25

    We investigate sub-monolayer InN quantum sheets embedded in GaN(0001) by temperature-dependent photoluminescence spectroscopy under both continuous-wave and pulsed excitation. Both the peak energy and the linewidth of the emission band associated with the quantum sheets exhibit an anomalous dependence on temperature indicative of carrier localization. Photoluminescence transients reveal a power law decay at low temperatures reflecting that the recombining electrons and holes occupy spatially separate, individual potential minima reminiscent of conventional (In,Ga)N(0001) quantum wells exhibiting the characteristic disorder of a random alloy. At elevated temperatures, carrier delocalization sets in and is accompanied by a thermally activated quenching of the emission.more » We ascribe the strong nonradiative recombination to extended states in the GaN barriers and confirm our assumption by a simple rate-equation model.« less

  16. Wide-field high spatial frequency domain imaging of tissue microstructure

    NASA Astrophysics Data System (ADS)

    Lin, Weihao; Zeng, Bixin; Cao, Zili; Zhu, Danfeng; Xu, M.

    2018-02-01

    Wide-field tissue imaging is usually not capable of resolving tissue microstructure. We present High Spatial Frequency Domain Imaging (HSFDI) - a noncontact imaging modality that spatially maps the tissue microscopic scattering structures over a large field of view. Based on an analytical reflectance model of sub-diffusive light from forward-peaked highly scattering media, HSFDI quantifies the spatially-resolved parameters of the light scattering phase function from the reflectance of structured light modulated at high spatial frequencies. We have demonstrated with ex vivo cancerous tissue to validate the robustness of HSFDI in significant contrast and differentiation of the microstructutral parameters between different types and disease states of tissue.

  17. Quantitative spatial frequency fluorescence imaging in the sub-diffusive domain for image-guided glioma resection

    PubMed Central

    Sibai, Mira; Veilleux, Israel; Elliott, Jonathan T.; Leblond, Frederic; Wilson, Brian C.

    2015-01-01

    Intraoperative 5- aminolevulinic acid induced-Protoporphyrin IX (PpIX) fluorescence guidance enables maximum safe resection of glioblastomas by providing surgeons with real-time tumor optical contrast. However, visual assessment of PpIX fluorescence is subjective and limited by the distorting effects of light attenuation and tissue autofluorescence. We have previously shown that non-invasive point measurements of absolute PpIX concentration identifies residual tumor that is otherwise non-detectable. Here, we extend this approach to wide-field quantitative fluorescence imaging by implementing spatial frequency domain imaging to recover tissue optical properties across the field-of-view in phantoms and ex vivo tissue. PMID:26713206

  18. Anomalous-hydrodynamic analysis of charge-dependent elliptic flow in heavy-ion collisions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hongo, Masaru; Hirono, Yuji; Hirano, Tetsufumi

    Anomalous hydrodynamics is a low-energy effective theory that captures effects of quantum anomalies. We develop a numerical code of anomalous hydrodynamics and apply it to dynamics of heavy-ion collisions, where anomalous transports are expected to occur. This is the first attempt to perform fully non-linear numerical simulations of anomalous hydrodynamics. We discuss implications of the simulations for possible experimental observations of anomalous transport effects. From analyses of the charge-dependent elliptic flow parameters (vmore » $$±\\atop{2}$$) as a function of the net charge asymmetry A ±, we find that the linear dependence of Δv$$±\\atop{2}$$ ≡ v$$-\\atop{2}$$ - v$$+\\atop{2}$$ on the net charge asymmetry A ± cannot be regarded as a robust signal of anomalous transports, contrary to previous studies. We, however, find that the intercept Δv$$±\\atop{2}$$ (A ± = 0) is sensitive to anomalous transport effects.« less

  19. Anomalous-hydrodynamic analysis of charge-dependent elliptic flow in heavy-ion collisions

    DOE PAGES

    Hongo, Masaru; Hirono, Yuji; Hirano, Tetsufumi

    2017-12-10

    Anomalous hydrodynamics is a low-energy effective theory that captures effects of quantum anomalies. We develop a numerical code of anomalous hydrodynamics and apply it to dynamics of heavy-ion collisions, where anomalous transports are expected to occur. This is the first attempt to perform fully non-linear numerical simulations of anomalous hydrodynamics. We discuss implications of the simulations for possible experimental observations of anomalous transport effects. From analyses of the charge-dependent elliptic flow parameters (vmore » $$±\\atop{2}$$) as a function of the net charge asymmetry A ±, we find that the linear dependence of Δv$$±\\atop{2}$$ ≡ v$$-\\atop{2}$$ - v$$+\\atop{2}$$ on the net charge asymmetry A ± cannot be regarded as a robust signal of anomalous transports, contrary to previous studies. We, however, find that the intercept Δv$$±\\atop{2}$$ (A ± = 0) is sensitive to anomalous transport effects.« less

  20. X-Ray Bursts from the Transient Magnetar Candidate XTE J1810-197

    NASA Technical Reports Server (NTRS)

    Kouveliotou, Chryssa; Woods, Peter M.; Gavriil, Fotis P.; Kaspi, Victoria M.; Roberts, Mallory S. E.; Ibrahim, Alaa; Markwardt, Craig B.; Swank, Jean H.; Finger, Mark H.

    2005-01-01

    We have discovered four X-ray bursts, recorded with the Rossi X-ray Timing Explorer Proportional Counter Array between 2003 September and 2004 April, that we show to originate from the transient magnetar candidate XTE 51810-197. The burst morphologies consist of a short spike or multiple spikes lasting approx. 1 s each followed by extended tails of emission where the pulsed flux from XTE 51810-197 is significantly higher. The burst spikes are likely correlated with the pulse maxima, having a chance probability of a random phase distribution of 0.4%. The burst spectra are best fit to a blackbody with temperatures 4-8 keV, considerably harder than the persistent X-ray emission. During the X-ray tails following these bursts, the temperature rapidly cools as the flux declines, maintaining a constant emitting radius after the initial burst peak. The temporal and spectral characteristics of these bursts closely resemble the bursts seen from 1E 1048.1-5937 and a subset of the bursts detected from 1E 2259+586, thus establishing XTE J1810-197 as a magnetar candidate. The bursts detected from these three objects are sufficiently similar to one another, yet si,g&cantly differe2t from those seen from soft gamma repeaters, that they likely represent a new class of bursts from magnetar candidates exclusive (thus far) to the anomalous X-ray pulsar-like sources.

  1. Delayed avalanche breakdown of high-voltage silicon diodes: Various structures exhibit different picosecond-range switching behavior

    NASA Astrophysics Data System (ADS)

    Brylevskiy, Viktor; Smirnova, Irina; Gutkin, Andrej; Brunkov, Pavel; Rodin, Pavel; Grekhov, Igor

    2017-11-01

    We present a comparative study of silicon high-voltage diodes exhibiting the effect of delayed superfast impact-ionization breakdown. The effect manifests itself in a sustainable picosecond-range transient from the blocking to the conducting state and occurs when a steep voltage ramp is applied to the p+-n-n+ diode in the reverse direction. Nine groups of diodes with graded and abrupt pn-junctions have been specially fabricated for this study by different techniques from different Si substrates. Additionally, in two groups of these structures, the lifetime of nonequilibrium carriers was intentionally reduced by electron irradiation. All diodes have identical geometrical parameters and similar stationary breakdown voltages. Our experimental setup allows measuring both device voltage and current during the kilovolt switching with time resolution better than 50 ps. Although all devices are capable of forming a front with kilovolt amplitude and 100 ps risetime in the in-series load, the structures with graded pn-junctions have anomalously large residual voltage. The Deep Level Transient Spectroscopy study of all diode structures has been performed in order to evaluate the effect of deep centers on device performance. It was found that the presence of deep-level electron traps negatively correlates with parameters of superfast switching, whereas a large concentration of recombination centers created by electron irradiation has virtually no influence on switching characteristics.

  2. Analysis of hydromechanical well tests in fractured sedimentary rock at the NAWC site, New Jersey

    USGS Publications Warehouse

    Murdoch, L.C.; Hisz, D.B.; Ebenhack, J.F.; Fowler, D.E.; Tiedeman, C.R.; Germanovich, L.N.

    2009-01-01

    Hydromechanical well tests involve measuring and interpreting displacements along with hydraulic heads that result when a hydraulic stress is applied to a well. The motivation behind this type of test is that the displacement measurements provide information about the constitutive properties and structure of the aquifer that go beyond what can be derived from pressure signals alone. We used a borehole extensometer to measure transient displacements with a resolution of +/- 25 nm during well tests in fractured mudstone and sandstone at the former Naval Air Warfare Center in West Trenton, New Jersey. One well showed opening displacements on the order of 300nm during slug tests with maximum head changes of 7 m. Inversion of the transient signals suggest that a conductive fracture (aperture = 380 ??m, normal stiffness = 8??10 8 Pa/m) was largely responsible for the pressure signal, but the displacement signal appears to have resulted from both the fracture and deformation of the enveloping sandstone (E = 5 GPa, permeability = 0.6 md). At another well, an anomalous but repeatable signal was characterized by closing displacements during increasing pressure. This displacement signal can be explained by a hydraulically active fracture below the extensometer that became pressurized and compressed the overly sediments. Poroelastic theoretical analyses were inverted to estimate parameters and verify interpretations. Copyright 2009 ARMA, American Rock Mechanics Association.

  3. Analytic cognitive style predicts paranormal explanations of anomalous experiences but not the experiences themselves: Implications for cognitive theories of delusions.

    PubMed

    Ross, Robert M; Hartig, Bjoern; McKay, Ryan

    2017-09-01

    It has been proposed that delusional beliefs are attempts to explain anomalous experiences. Why, then, do anomalous experiences induce delusions in some people but not in others? One possibility is that people with delusions have reasoning biases that result in them failing to reject implausible candidate explanations for anomalous experiences. We examine this hypothesis by studying paranormal interpretations of anomalous experiences. We examined whether analytic cognitive style (i.e. the willingness or disposition to critically evaluate outputs from intuitive processing and engage in effortful analytic processing) predicted anomalous experiences and paranormal explanations for these experiences after controlling for demographic variables and cognitive ability. Analytic cognitive style predicted paranormal explanations for anomalous experiences, but not the anomalous experiences themselves. We did not study clinical delusions. Our attempts to control for cognitive ability may have been inadequate. Our sample was predominantly students. Limited analytic cognitive style might contribute to the interpretation of anomalous experiences in terms of delusional beliefs. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. Anomalous-hydrodynamic analysis of charge-dependent elliptic flow in heavy-ion collisions

    NASA Astrophysics Data System (ADS)

    Hongo, Masaru; Hirono, Yuji; Hirano, Tetsufumi

    2017-12-01

    Anomalous hydrodynamics is a low-energy effective theory that captures effects of quantum anomalies. We develop a numerical code of ideal anomalous hydrodynamics and apply it to dynamics of heavy-ion collisions, where anomalous transports are expected to occur. We discuss implications of the simulations for possible experimental observations of anomalous transport effects. From analyses of the charge-dependent elliptic flow parameters (v2±) as a function of the net charge asymmetry A±, we find that the linear dependence of Δ v2± ≡ v2- - v2+ on the net charge asymmetry A± can come from a mechanism unrelated to anomalous transport effects. Instead, we find that a finite intercept Δ v2± (A± = 0) can come from anomalous effects.

  5. Fully interferometric controllable anomalous refraction efficiency using cross modulation with plasmonic metasurfaces.

    PubMed

    Liu, Zhaocheng; Chen, Shuqi; Li, Jianxiong; Cheng, Hua; Li, Zhancheng; Liu, Wenwei; Yu, Ping; Xia, Ji; Tian, Jianguo

    2014-12-01

    We present a method of fully interferometric, controllable anomalous refraction efficiency by introducing cross-modulated incident light based on plasmonic metasurfaces. Theoretical analyses and numerical simulations indicate that the anomalous and ordinary refracted beams generated from two opposite-helicity incident beams and following the generalized Snell's law will have a superposition for certain incident angles, and the anomalous refraction efficiency can be dynamically controlled by changing the relative phase of the incident sources. As the incident wavelength nears the resonant wavelength of the plasmonic metasurfaces, two equal-amplitude incident beams with opposite helicity can be used to control the anomalous refraction efficiency. Otherwise, two unequal-amplitude incident beams with opposite helicity can be used to fully control the anomalous refraction efficiency. This Letter may offer a further step in the development of controllable anomalous refraction.

  6. Convectively Driven Tropopause-Level Cooling and Its Influences on Stratospheric Moisture

    NASA Astrophysics Data System (ADS)

    Kim, Joowan; Randel, William J.; Birner, Thomas

    2018-01-01

    Characteristics of the tropopause-level cooling associated with tropical deep convection are examined using CloudSat radar and Constellation Observing System for Meteorology, Ionosphere and Climate (COSMIC) GPS radio occultation measurements. Extreme deep convection is sampled based on the cloud top height (>17 km) from CloudSat, and colocated temperature profiles from COSMIC are composited around the deep convection. Response of moisture to the tropopause-level cooling is also examined in the upper troposphere and lower stratosphere using microwave limb sounder measurements. The composite temperature shows an anomalous warming in the troposphere and a significant cooling near the tropopause (at 16-19 km) when deep convection occurs over the western Pacific, particularly during periods with active Madden-Julian Oscillation (MJO). The composite of the tropopause cooling has a large horizontal scale ( 6,000 km in longitude) with minimum temperature anomaly of -2 K, and it lasts more than 2 weeks with support of mesoscale convective clusters embedded within the envelope of the MJO. The water vapor anomalies show strong correlation with the temperature anomalies (i.e., dry anomaly in the cold anomaly), showing that the convectively driven tropopause cooling actively dehydrate the lower stratosphere in the western Pacific region. The moisture is also affected by anomalous Matsuno-Gill-type circulation associated with the cold anomaly, in which dry air spreads over a wide range in the tropical tropopause layer (TTL). These results suggest that convectively driven tropopause cooling and associated transient circulation play an important role in the large-scale dehydration process in the TTL.

  7. Spectral formation in a radiative shock: application to anomalous X-ray pulsars and soft gamma-ray repeaters

    NASA Astrophysics Data System (ADS)

    Kylafis, N. D.; Trümper, J. E.; Ertan, Ü.

    2014-02-01

    Context. In the fallback disk model for the persistent emission of anomalous X-ray pulsars (AXPs) and soft gamma-ray repeaters (SGRs), the hard X-ray emission arises from bulk- and thermal Comptonization of bremsstrahlung photons, which are generated in the accretion column. The relatively low X-ray luminosity of these sources implies a moderate transverse optical depth to electron scattering, with photons executing a small number of shock crossings before escaping sideways. Aims: We explore the range of spectral shapes that can be obtained with this model and characterize the most important parameter dependencies. Methods: We use a Monte Carlo code to study the crisscrossing of photons in a radiative shock in an accretion column and compute the resulting spectrum. Results: As expected, high-energy power-law X-ray spectra are produced in radiative shocks with photon-number spectral index Γ ≳ 0.5. We find that the required transverse optical depth is 1 ≲ τ⊥ ≲ 7. Such spectra are observed in low-luminosity X-ray pulsars. Conclusions: We demonstrate here with a simple model that Compton upscattering in the radiative shock in the accretion column can produce hard X-ray spectra similar to those seen in the persistent and transient emission of AXPs and SGRs. In particular, one can obtain a high-energy power-law spectrum, with photon-number spectral-index Γ ~ 1 and a cutoff at 100 - 200 keV, with a transverse Thomson optical depth of ~5, which is shown to be typical in AXPs/SGRs.

  8. Contemporary Use of Anomalous Diffraction in Biomolecular Structure Analysis.

    PubMed

    Liu, Qun; Hendrickson, Wayne A

    2017-01-01

    The normal elastic X-ray scattering that depends only on electron density can be modulated by an "anomalous" component due to resonance between X-rays and electronic orbitals. Anomalous scattering thereby precisely identifies atomic species, since orbitals distinguish atomic elements, which enables the multi- and single-wavelength anomalous diffraction (MAD and SAD) methods. SAD now predominates in de novo structure determination of biological macromolecules, and we focus here on the prevailing SAD method. We describe the anomalous phasing theory and the periodic table of phasing elements that are available for SAD experiments, differentiating between those readily accessible for at-resonance experiments and those that can be effective away from an edge. We describe procedures for present-day SAD phasing experiments and we discuss optimization of anomalous signals for challenging applications. We also describe methods for using anomalous signals as molecular markers for tracing and element identification. Emerging developments and perspectives are discussed in brief.

  9. Total anomalous systemic with partial anomalous pulmonary venous connections.

    PubMed

    Vallath, Gopakumar; Gajjar, Trushar; Desai, Neelam

    2013-12-01

    A 9-year-old girl with cyanosis, dyspnea, and grade II clubbing was diagnosed by contrast transthoracic echocardiography and angiocardiography to have an anomalous connection of the venae cavae to the physiologic left atrium with partial anomalous pulmonary venous connection. Successful surgical correction was achieved, and the patient's recovery was uneventful.

  10. Areas of Weakly Anomalous to Anomalous Surface Temperature in Chaffee County, Colorado, as Identified from ASTER Thermal Data

    DOE Data Explorer

    Khalid Hussein

    2012-02-01

    Note: This "Weakly Anomalous to Anomalous Surface Temperature" dataset differs from the "Anomalous Surface Temperature" dataset for this county (another remotely sensed CIRES product) by showing areas of modeled temperatures between 1o and 2o above the mean, as opposed to the greater than 2o temperatures contained in the "Anomalous Surface Temperature" dataset. This layer contains areas of anomalous surface temperature in Chaffee County identified from ASTER thermal data and spatial based insolation model. The temperature is calculated using the Emissivity Normalization Algorithm that separate temperature from emissivity. The incoming solar radiation was calculated using spatial based insolation model developed by Fu and Rich (1999). Then the temperature due to solar radiation was calculated using emissivity derived from ASTER data. The residual temperature, i.e. temperature due to solar radiation subtracted from ASTER temperature was used to identify thermally anomalous areas. Areas that had temperature greater than 2o were considered ASTER modeled very warm surface exposures (thermal anomalies). Note: 'o' is used in this description to represent lowercase sigma.

  11. Areas of Weakly Anomalous to Anomalous Surface Temperature in Garfield County, Colorado, as Identified from ASTER Thermal Data

    DOE Data Explorer

    Khalid Hussein

    2012-02-01

    Note: This "Weakly Anomalous to Anomalous Surface Temperature" dataset differs from the "Anomalous Surface Temperature" dataset for this county (another remotely sensed CIRES product) by showing areas of modeled temperatures between 1o and 2o above the mean, as opposed to the greater than 2o temperatures contained in the "Anomalous Surface Temperature" dataset. This layer contains areas of anomalous surface temperature in Garfield County identified from ASTER thermal data and spatial based insolation model. The temperature is calculated using the Emissivity Normalization Algorithm that separate temperature from emissivity. The incoming solar radiation was calculated using spatial based insolation model developed by Fu and Rich (1999). Then the temperature due to solar radiation was calculated using emissivity derived from ASTER data. The residual temperature, i.e. temperature due to solar radiation subtracted from ASTER temperature was used to identify thermally anomalous areas. Areas that had temperature between 1o and 2o were considered ASTER modeled warm surface exposures (thermal anomalies) Note: 'o' is used in this description to represent lowercase sigma.

  12. Areas of Weakly Anomalous to Anomalous Surface Temperature in Routt County, Colorado, as Identified from ASTER Thermal Data

    DOE Data Explorer

    Khalid Hussein

    2012-02-01

    Note: This "Weakly Anomalous to Anomalous Surface Temperature" dataset differs from the "Anomalous Surface Temperature" dataset for this county (another remotely sensed CIRES product) by showing areas of modeled temperatures between 1o and 2o above the mean, as opposed to the greater than 2o temperatures contained in the "Anomalous Surface Temperature" dataset. This layer contains areas of anomalous surface temperature in Routt County identified from ASTER thermal data and spatial based insolation model. The temperature is calculated using the Emissivity Normalization Algorithm that separate temperature from emissivity. The incoming solar radiation was calculated using spatial based insolation model developed by Fu and Rich (1999). Then the temperature due to solar radiation was calculated using emissivity derived from ASTER data. The residual temperature, i.e. temperature due to solar radiation subtracted from ASTER temperature was used to identify thermally anomalous areas. Areas that had temperature between 1o and 2o were considered ASTER modeled warm surface exposures (thermal anomalies). Note: 'o' is used in this description to represent lowercase sigma.

  13. Areas of Weakly Anomalous to Anomalous Surface Temperature in Dolores County, Colorado, as Identified from ASTER Thermal Data

    DOE Data Explorer

    Khalid Hussein

    2012-02-01

    Note: This "Weakly Anomalous to Anomalous Surface Temperature" dataset differs from the "Anomalous Surface Temperature" dataset for this county (another remotely sensed CIRES product) by showing areas of modeled temperatures between 1o and 2o above the mean, as opposed to the greater than 2o temperatures contained in the "Anomalous Surface Temperature" dataset. This layer contains areas of anomalous surface temperature in Dolores County identified from ASTER thermal data and spatial based insolation model. The temperature is calculated using the Emissivity Normalization Algorithm that separate temperature from emissivity. The incoming solar radiation was calculated using spatial based insolation model developed by Fu and Rich (1999). Then the temperature due to solar radiation was calculated using emissivity derived from ASTER data. The residual temperature, i.e. temperature due to solar radiation subtracted from ASTER temperature was used to identify thermally anomalous areas. Areas that had temperature greater than 2o were considered ASTER modeled very warm surface exposures (thermal anomalies) Note: 'o' is used in this description to represent lowercase sigma.

  14. Areas of Weakly Anomalous to Anomalous Surface Temperature in Archuleta County, Colorado, as Identified from ASTER Thermal Data

    DOE Data Explorer

    Khalid Hussein

    2012-02-01

    Note: This "Weakly Anomalous to Anomalous Surface Temperature" dataset differs from the "Anomalous Surface Temperature" dataset for this county (another remotely sensed CIRES product) by showing areas of modeled temperatures between 1o and 2o above the mean, as opposed to the greater than 2o temperatures contained in the "Anomalous Surface Temperature" dataset. This layer contains areas of anomalous surface temperature in Archuleta County identified from ASTER thermal data and spatial based insolation model. The temperature is calculated using the Emissivity Normalization Algorithm that separate temperature from emissivity. The incoming solar radiation was calculated using spatial based insolation model developed by Fu and Rich (1999). Then the temperature due to solar radiation was calculated using emissivity derived from ASTER data. The residual temperature, i.e. temperature due to solar radiation subtracted from ASTER temperature was used to identify thermally anomalous areas. Areas that had temperature between 1o and 2o were considered ASTER modeled warm surface exposures (thermal anomalies). Note: 'o' is used in this description to represent lowercase sigma.

  15. Almost conserved operators in nearly many-body localized systems

    NASA Astrophysics Data System (ADS)

    Pancotti, Nicola; Knap, Michael; Huse, David A.; Cirac, J. Ignacio; Bañuls, Mari Carmen

    2018-03-01

    We construct almost conserved local operators, that possess a minimal commutator with the Hamiltonian of the system, near the many-body localization transition of a one-dimensional disordered spin chain. We collect statistics of these slow operators for different support sizes and disorder strengths, both using exact diagonalization and tensor networks. Our results show that the scaling of the average of the smallest commutators with the support size is sensitive to Griffiths effects in the thermal phase and the onset of many-body localization. Furthermore, we demonstrate that the probability distributions of the commutators can be analyzed using extreme value theory and that their tails reveal the difference between diffusive and subdiffusive dynamics in the thermal phase.

  16. Characteristic length scale dependence on conductivity for La2-xErxMo2O9 (0.05 ≤ x ≤ 0.3) oxide ion conductors

    NASA Astrophysics Data System (ADS)

    Paul, T.; Ghosh, A.

    2016-05-01

    Structural property of polycrystalline La2-xErxMo2O9 has been investigated. Rietveld refinements at room temperature of the materials suggest a single phase nature with cubic symmetry (space group P213). The electron density contour plot confirms the nature of different cation-oxygen bonds. Time dependent mean square displacement (√) and the spatial extent of the sub-diffusive motion (√) are evaluated using the linear response theory. The localized hop at O2 and O3 sites is found to be favorable for oxygen ion migration for these systems.

  17. Electronic transport in disordered chains with saturable nonlinearity

    NASA Astrophysics Data System (ADS)

    dos Santos, J. L. L.; Nguyen, Ba Phi; de Moura, F. A. B. F.

    2015-10-01

    In this work we study numerically the dynamics of an initially localized wave packet in one-dimensional disordered chains with saturable nonlinearity. By using the generalized discrete nonlinear Schrödinger equation, we calculate two different physical quantities as a function of time, which are the participation number and the mean square displacement from the excitation site. From detailed numerical analysis, we find that the saturable nonlinearity can promote a sub-diffusive spreading of the wave packet even in the presence of diagonal disorder for a long time. In addition, we also investigate the effect of the saturated nonlinearity for initial times of the electronic evolution thus showing the possibility of mobile breather-like modes.

  18. Malignant Course of Anomalous Left Coronary Artery Causing Sudden Cardiac Arrest: A Case Report and Review of the Literature.

    PubMed

    Anantha Narayanan, Mahesh; DeZorzi, Christopher; Akinapelli, Abhilash; Mahfood Haddad, Toufik; Smer, Aiman; Baskaran, Janani; Biddle, William P

    2015-01-01

    Sudden cardiac arrest has been reported to occur in patients with congenital anomalous coronary artery disease. About 80% of the anomalies are benign and incidental findings at the time of catheterization. We present a case of sudden cardiac arrest caused by anomalous left anterior descending artery. 61-year-old African American female was brought to the emergency department after sudden cardiac arrest. Initial EKG showed sinus rhythm with RBBB and LAFB with nonspecific ST-T wave changes. Coronary angiogram revealed no atherosclerotic disease. The left coronary artery was found to originate from the right coronary cusp. Cardiac CAT scan revealed similar findings with interarterial and intramural course. Patient received one-vessel arterial bypass graft to her anomalous coronary vessel along with a defibrillator for secondary prevention. Sudden cardiac arrest secondary to congenital anomalous coronary artery disease is characterized by insufficient coronary flow by the anomalous left coronary artery to meet elevated left ventricular (LV) myocardial demand. High risk defects include those involved with the proximal coronary artery or coursing of the anomalous artery between the aorta and pulmonary trunk. Per guidelines, our patient received one vessel bypass graft to her anomalous vessel. It is important for clinicians to recognize such presentations of anomalous coronary artery.

  19. NLO BFKL and Anomalous Dimensions of Light-Ray Operators

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Balitsky, Ian

    2014-01-01

    The anomalous dimensions of light-ray operators of twist two are obtained by analytical continuation of the anomalous dimensions of corresponding local operators. I demonstrate that the asymptotics of these anomalous dimensions at the "BFKL point" j → 1 can be obtained by comparing the light-cone operator expansion with the high-energy expansion in Wilson lines.

  20. General PFG signal attenuation expressions for anisotropic anomalous diffusion by modified-Bloch equations

    NASA Astrophysics Data System (ADS)

    Lin, Guoxing

    2018-05-01

    Anomalous diffusion exists widely in polymer and biological systems. Pulsed-field gradient (PFG) anomalous diffusion is complicated, especially in the anisotropic case where limited research has been reported. A general PFG signal attenuation expression, including the finite gradient pulse (FGPW) effect for free general anisotropic fractional diffusion { 0 < α , β ≤ 2 } based on the fractional derivative, has not been obtained, where α and β are time and space derivative orders. It is essential to derive a general PFG signal attenuation expression including the FGPW effect for PFG anisotropic anomalous diffusion research. In this paper, two recently developed modified-Bloch equations, the fractal differential modified-Bloch equation and the fractional integral modified-Bloch equation, were extended to obtain general PFG signal attenuation expressions for anisotropic anomalous diffusion. Various cases of PFG anisotropic anomalous diffusion were investigated, including coupled and uncoupled anisotropic anomalous diffusion. The continuous-time random walk (CTRW) simulation was also carried out to support the theoretical results. The theory and the CTRW simulation agree with each other. The obtained signal attenuation expressions and the three-dimensional fractional modified-Bloch equations are important for analyzing PFG anisotropic anomalous diffusion in NMR and MRI.

  1. Observation of anomalous Hall effect in a non-magnetic two-dimensional electron system

    PubMed Central

    Maryenko, D.; Mishchenko, A. S.; Bahramy, M. S.; Ernst, A.; Falson, J.; Kozuka, Y.; Tsukazaki, A.; Nagaosa, N.; Kawasaki, M.

    2017-01-01

    Anomalous Hall effect, a manifestation of Hall effect occurring in systems without time-reversal symmetry, has been mostly observed in ferromagnetically ordered materials. However, its realization in high-mobility two-dimensional electron system remains elusive, as the incorporation of magnetic moments deteriorates the device performance compared to non-doped structure. Here we observe systematic emergence of anomalous Hall effect in various MgZnO/ZnO heterostructures that exhibit quantum Hall effect. At low temperatures, our nominally non-magnetic heterostructures display an anomalous Hall effect response similar to that of a clean ferromagnetic metal, while keeping a large anomalous Hall effect angle θAHE≈20°. Such a behaviour is consistent with Giovannini–Kondo model in which the anomalous Hall effect arises from the skew scattering of electrons by localized paramagnetic centres. Our study unveils a new aspect of many-body interactions in two-dimensional electron systems and shows how the anomalous Hall effect can emerge in a non-magnetic system. PMID:28300133

  2. Contemporary Use of Anomalous Diffraction in Biomolecular Structure Analysis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu Q.; Hendrickson, W.

    2017-01-01

    The normal elastic X-ray scattering that depends only on electron density can be modulated by an ?anomalous? component due to resonance between X-rays and electronic orbitals. Anomalous scattering thereby precisely identifies atomic species, since orbitals distinguish atomic elements, which enables the multi- and single-wavelength anomalous diffraction (MAD and SAD) methods. SAD now predominates in de novo structure determination of biological macromolecules, and we focus here on the prevailing SAD method. We describe the anomalous phasing theory and the periodic table of phasing elements that are available for SAD experiments, differentiating between those readily accessible for at-resonance experiments and those thatmore » can be effective away from an edge. We describe procedures for present-day SAD phasing experiments and we discuss optimization of anomalous signals for challenging applications. We also describe methods for using anomalous signals as molecular markers for tracing and element identification. Emerging developments and perspectives are discussed in brief.« less

  3. Anomalous dual drainage of the right pulmonary veins in a patient with cor triatriatum: report of a case without scimitar sign.

    PubMed

    Tansel, T; Harmandar, B; Dayioglu, E; Onursal, E

    2006-02-01

    The majority of patients with partial anomalous drainage of pulmonary veins are asymptomatic during infancy and childhood. Patients with significant left-to-right shunt develop symptoms and benefit from early corrective surgery. Anomalous pulmonary veins draining into inferior vena cava is very rare and frequently encountered in association with scimitar syndrome. The purpose of this case report is to describe a non-scimitar patient with cor triatriatum who had anomalous dual drainage of right pulmonary veins into inferior vena cava/left atrium and anomalous connection of persistent left superior vena cava with a common pulmonary venous chamber. The patient underwent an operation with redirection of anomalous pulmonary venous drainage into left atrium and ligation of persistent left superior vena cava.

  4. Non-universal tracer diffusion in crowded media of non-inert obstacles.

    PubMed

    Ghosh, Surya K; Cherstvy, Andrey G; Metzler, Ralf

    2015-01-21

    We study the diffusion of a tracer particle, which moves in continuum space between a lattice of excluded volume, immobile non-inert obstacles. In particular, we analyse how the strength of the tracer-obstacle interactions and the volume occupancy of the crowders alter the diffusive motion of the tracer. From the details of partitioning of the tracer diffusion modes between trapping states when bound to obstacles and bulk diffusion, we examine the degree of localisation of the tracer in the lattice of crowders. We study the properties of the tracer diffusion in terms of the ensemble and time averaged mean squared displacements, the trapping time distributions, the amplitude variation of the time averaged mean squared displacements, and the non-Gaussianity parameter of the diffusing tracer. We conclude that tracer-obstacle adsorption and binding triggers a transient anomalous diffusion. From a very narrow spread of recorded individual time averaged trajectories we exclude continuous type random walk processes as the underlying physical model of the tracer diffusion in our system. For moderate tracer-crowder attraction the motion is found to be fully ergodic, while at stronger attraction strength a transient disparity between ensemble and time averaged mean squared displacements occurs. We also put our results into perspective with findings from experimental single-particle tracking and simulations of the diffusion of tagged tracers in dense crowded suspensions. Our results have implications for the diffusion, transport, and spreading of chemical components in highly crowded environments inside living cells and other structured liquids.

  5. Transport, diffusion, and energy studies in the Arnold-Beltrami-Childress map

    NASA Astrophysics Data System (ADS)

    Das, Swetamber; Gupte, Neelima

    2017-09-01

    We study the transport and diffusion properties of passive inertial particles described by a six-dimensional dissipative bailout embedding map. The base map chosen for the study is the three-dimensional incompressible Arnold-Beltrami-Childress (ABC) map chosen as a representation of volume preserving flows. There are two distinct cases: the two-action and the one-action cases, depending on whether two or one of the parameters (A ,B ,C ) exceed 1. The embedded map dynamics is governed by two parameters (α ,γ ), which quantify the mass density ratio and dissipation, respectively. There are important differences between the aerosol (α <1 ) and the bubble (α >1 ) regimes. We have studied the diffusive behavior of the system and constructed the phase diagram in the parameter space by computing the diffusion exponents η . Three classes have been broadly classified—subdiffusive transport (η <1 ), normal diffusion (η ≈1 ), and superdiffusion (η >1 ) with η ≈2 referred to as the ballistic regime. Correlating the diffusive phase diagram with the phase diagram for dynamical regimes seen earlier, we find that the hyperchaotic bubble regime is largely correlated with normal and superdiffusive behavior. In contrast, in the aerosol regime, ballistic superdiffusion is seen in regions that largely show periodic dynamical behaviors, whereas subdiffusive behavior is seen in both periodic and chaotic regimes. The probability distributions of the diffusion exponents show power-law scaling for both aerosol and bubbles in the superdiffusive regimes. We further study the Poincáre recurrence times statistics of the system. Here, we find that recurrence time distributions show power law regimes due to the existence of partial barriers to transport in the phase space. Moreover, the plot of average particle kinetic energies versus the mass density ratio for the two-action case exhibits a devil's staircase-like structure for higher dissipation values. We explain these results and discuss their implications for realistic systems.

  6. Permeability of a Fluid Lipid Bilayer to Short-Chain Alcohols from First Principles.

    PubMed

    Comer, Jeffrey; Schulten, Klaus; Chipot, Christophe

    2017-06-13

    Computational prediction of membrane permeability to small molecules requires accurate description of both the thermodynamics and kinetics underlying translocation across the lipid bilayer. In this contribution, well-converged, microsecond-long free-energy calculations are combined with a recently developed subdiffusive kinetics framework to describe the membrane permeation of a homologous series of short-tail alcohols, from methanol to 1-butanol, with unprecedented fidelity to the underlying molecular models. While the free-energy profiles exhibit barriers for passage through the center of the bilayer in all cases, the height of these barriers decreases with the length of the aliphatic chain of the alcohol, in quantitative agreement with experimentally determined differential solvation free energies in water and oil. A unique aspect of the subdiffusive model employed herein, which was developed in a previous article, is the determination of a position-dependent fractional order which quantifies the degree to which the motion of the alcohol deviates from classical diffusion along the thickness of the membrane. In the aqueous medium far from the bilayer, this quantity approaches 1.0, the asymptotic limit for purely classical diffusion, whereas it dips below 0.75 near the center of the membrane irrespective of the permeant. Remarkably, the fractional diffusivity near the center of membrane, where its influence on the permeability is the greatest, is similar among the four permeants despite the large difference in molecular weight and lipophilicity between methanol and 1-butanol. The relative permeabilities, which are estimated from the free-energy and fractional diffusivity profiles, are therefore determined predominantly by differences in the former rather than the latter. The predicted relative permeabilities are highly correlated with existing experimental results, albeit they do not agree quantitatively with them. On the other hand, quite unexpectedly, the reported experimental values for the short-tail alcohols are nearly three orders of magnitude lower than the available experimental measurement for water. Plausible explanations for this apparent disagreement between theory and experiment are considered in detail.

  7. Thoracoscopic Surgery for Partial Anomalous Pulmonary Venous Connection with Dual Drainage.

    PubMed

    Fuchigami, Tai; Gabe, Atsushi; Takahashi, Kazuhiro; Nishioka, Masahiko; Akashige, Toru; Nagata, Nobuhiro

    2015-10-01

    We report our technique for thoracoscopic surgery for a 15-year-old female (body weight, 59 kg) diagnosed with partial anomalous pulmonary venous connection with dual drainage. A large anomalous right lower pulmonary vein (RLPV) was drained into the inferior vena cava and left atrium, along with thoracoscopic ligation and clipping of RLPV and some anomalous hepatic veins. © 2015 Wiley Periodicals, Inc.

  8. Transient bedrock channel evolution across a precipitation gradient: A case study from Kohala, Hawaii.

    NASA Astrophysics Data System (ADS)

    Gasparini, N. M.; Han, J.; Johnson, J. P.; Menking, J. A.

    2011-12-01

    This study uses observations from the Kohala Peninsula, on the Big Island of Hawaii, and numerical modeling, to explore how precipitation gradients may affect fluvial bedrock incision and channel morphology. Orographic precipitation patterns result in over 4 m/yr of rainfall on the wet side of the peninsula and less than 0.5 m/yr on the dry side. These precipitation patterns likely strongly contribute to the observed channel morphology. Further, the region is subsiding, leading to prolonged transient channel evolution. We explore changes in a number of channel morphologic parameters with watershed averaged precipitation rate. We use PRISM precipitation data and data from isohyets developed from historic rain gauge data. Not surprisingly, valley depth, measured from a 10 meter DEM, increases with spatially averaged precipitation rate. We also find that channel profile form varies with precipitation rate, with drier channels exhibiting a straight to slightly concave channel form and wetter channels exhibiting a convex to concave channel form. The precipitation value at which this transition in channel profile form occurs depends on the precipitation data-set used, highlighting the need for more accurate measurements of precipitation in settings with extreme precipitation patterns similar to our study area. The downstream pattern in precipitation is likely significant in the development of the convex-concave profile form. Numerical modeling results support that precipitation patterns such as those observed on the wet-side of the Kohala Peninsula may contribute to the convex-concave profile form. However, we emphasize that while precipitation patterns may contribute to the channel form, these channel features are transient and not expected to be sustained in steady-state landscapes. We also emphasize that it is fluvial discharge, as driven by precipitation, rather than precipitation alone, that drives the processes shaping the channel form. Because fluvial discharge is integrative, relatively extreme precipitation gradients are required to produce anomalous channel profile forms.

  9. Theoretical analyses of resonant frequency shift in anomalous dispersion enhanced resonant optical gyroscopes.

    PubMed

    Lin, Jian; Liu, Jiaming; Zhang, Hao; Li, Wenxiu; Zhao, Lu; Jin, Junjie; Huang, Anping; Zhang, Xiaofu; Xiao, Zhisong

    2016-12-12

    Rigorous expressions of resonant frequency shift (RFS) in anomalous dispersion enhanced resonant optical gyroscopes (ADEROGs) are deduced without making approximation, which provides a precise theoretical guidance to achieve ultra-sensitive ADEROGs. A refractive index related modification factor is introduced when considering special theory of relativity (STR). We demonstrate that the RFS will not be "infinitely large" by using critical anomalous dispersion (CAD) and negative modification does not exist, which make the mechanism of anomalous dispersion enhancement clear and coherent. Although step change of RFS will happen when the anomalous dispersion condition varies, the amplification of RFS is limited by attainable variation of refractive index in practice. Moreover, it is shown that the properties of anomalous dispersion will influence not only the amplification of RFS, but also the detection range of ADEROGs.

  10. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hegde, Raghurama P.; Fedorov, Alexander A.; Sauder, J. Michael

    Single-wavelength anomalous dispersion (SAD) utilizing anomalous signal from native S atoms, or other atoms withZ≤ 20, generally requires highly redundant data collected using relatively long-wavelength X-rays. Here, the results from two proteins are presented where the anomalous signal from serendipitously acquired surface-bound Ca atoms with an anomalous data multiplicity of around 10 was utilized to drivede novostructure determination. In both cases, the Ca atoms were acquired from the crystallization solution, and the data-collection strategy was not optimized to exploit the anomalous signal from these scatterers. The X-ray data were collected at 0.98 Å wavelength in one case and at 1.74more » Å in the other (the wavelength was optimized for sulfur, but the anomalous signal from calcium was exploited for structure solution). Similarly, using a test case, it is shown that data collected at ~1.0 Å wavelength, where thef'' value for sulfur is 0.28 e, are sufficient for structure determination using intrinsic S atoms from a strongly diffracting crystal. Interestingly, it was also observed thatSHELXDwas capable of generating a substructure solution from high-exposure data with a completeness of 70% for low-resolution reflections extending to 3.5 Å resolution with relatively low anomalous multiplicity. Considering the fact that many crystallization conditions contain anomalous scatterers such as Cl, Ca, Mnetc., checking for the presence of fortuitous anomalous signal in data from well diffracting crystals could prove useful in either determining the structurede novoor in accurately assigning surface-bound atoms.« less

  11. Background and Recent Progress in Anomalous Transport Simulation

    DTIC Science & Technology

    2017-07-19

    NUMBER (Include area code) 19 July 2017 Briefing Charts 14 June 2017 - 19 July 2017 Background and Recent Progress in Anomalous Transport Simulation ...and Recent Progress in Anomalous Transport Simulation 19 Jul 2017 Justin Koo AFRL/RQRS Edwards AFB, CA 2DISTRIBUTION A: Approved for public release...Baalrud, S.D. and Chabert, P., “Theory for the anomalous electron transport in Hall effect thrusters. I. Insights from particle-in-cell simulations

  12. Taking Snapshots of Photosynthetic Water Oxidation Using Femtosecond X-ray Diffraction and Spectroscopy

    PubMed Central

    Kern, Jan; Tran, Rosalie; Alonso-Mori, Roberto; Koroidov, Sergey; Echols, Nathaniel; Hattne, Johan; Ibrahim, Mohamed; Gul, Sheraz; Laksmono, Hartawan; Sierra, Raymond G.; Gildea, Richard J.; Han, Guangye; Hellmich, Julia; Lassalle-Kaiser, Benedikt; Chatterjee, Ruchira; Brewster, Aaron S.; Stan, Claudiu A.; Glöckner, Carina; Lampe, Alyssa; DiFiore, Dörte; Milathianaki, Despina; Fry, Alan R.; Seibert, M. Marvin; Koglin, Jason E.; Gallo, Erik; Uhlig, Jens; Sokaras, Dimosthenis; Weng, Tsu-Chien; Zwart, Petrus H.; Skinner, David E.; Bogan, Michael J.; Messerschmidt, Marc; Glatzel, Pieter; Williams, Garth J.; Boutet, Sébastien; Adams, Paul D.; Zouni, Athina; Messinger, Johannes; Sauter, Nicholas K.; Bergmann, Uwe; Yano, Junko; Yachandra, Vittal K.

    2014-01-01

    The dioxygen we breathe is formed from water by its light-induced oxidation in photosystem II. O2 formation takes place at a catalytic manganese cluster within milliseconds after the photosystem II reaction center is excited by three single-turnover flashes. Here we present combined X-ray emission spectra and diffraction data of 2 flash (2F) and 3 flash (3F) photosystem II samples, and of a transient 3F′ state (250 μs after the third flash), collected under functional conditions using an X-ray free electron laser. The spectra show that the initial O-O bond formation, coupled to Mn-reduction, does not yet occur within 250 μs after the third flash. Diffraction data of all states studied exhibit an anomalous scattering signal from Mn but show no significant structural changes at the present resolution of 4.5 Å. This study represents the initial frames in a molecular movie of the structural changes during the catalytic reaction in photosystem II. PMID:25006873

  13. A non-linear induced polarization effect on transient electromagnetic soundings

    NASA Astrophysics Data System (ADS)

    Hallbauer-Zadorozhnaya, Valeriya Yu.; Santarato, Giovanni; Abu Zeid, Nasser; Bignardi, Samuel

    2016-10-01

    In a TEM survey conducted for characterizing the subsurface for geothermal purposes, a strong induced polarization effect was recorded in all collected data. Surprisingly, anomalous decay curves were obtained in part of the sites, whose shape depended on the repetition frequency of the exciting square waveform, i.e. on current pulse length. The Cole-Cole model, besides being not directly related to physical parameters of rocks, was found inappropriate to model the observed distortion, due to induced polarization, because this model is linear, i.e. it cannot fit any dependence on current pulse. This phenomenon was investigated and explained as due to the presence of membrane polarization linked to constrictivity of (fresh) water-saturated pores. An algorithm for mathematical modeling of TEM data was then developed to fit this behavior. The case history is then discussed: 1D inversion, which accommodates non-linear effects, produced models that agree quite satisfactorily with resistivity and chargeability models obtained by an electrical resistivity tomography carried out for comparison.

  14. Improved L-C resonant decay technique for Q measurement of quasilinear power inductors: New results for MPP and ferrite powdered cores

    NASA Technical Reports Server (NTRS)

    Niedra, Janis M.; Gerber, Scott S.

    1995-01-01

    The L-C resonant decay technique for measuring circuit Q or losses is improved by eliminating the switch from the inductor-capacitor loop. A MOSFET switch is used instead to momentarily connect the resonant circuit to an existing voltage source, which itself is gated off during the decay transient. Very reproducible, low duty cycle data could be taken this way over a dynamic voltage range of at least 10:1. Circuit Q is computed from a polynomial fit to the sequence of the decaying voltage maxima. This method was applied to measure the losses at 60 kHz in inductors having loose powder cores of moly permalloy and an Mn-Zn power ferrite. After the copper and capacitor losses are separated out, the resulting specific core loss is shown to be roughly as expected for the MPP powder, but anomalously high for the ferrite powder. Possible causes are mentioned.

  15. Taking snapshots of photosynthetic water oxidation using femtosecond X-ray diffraction and spectroscopy

    NASA Astrophysics Data System (ADS)

    Kern, Jan; Tran, Rosalie; Alonso-Mori, Roberto; Koroidov, Sergey; Echols, Nathaniel; Hattne, Johan; Ibrahim, Mohamed; Gul, Sheraz; Laksmono, Hartawan; Sierra, Raymond G.; Gildea, Richard J.; Han, Guangye; Hellmich, Julia; Lassalle-Kaiser, Benedikt; Chatterjee, Ruchira; Brewster, Aaron S.; Stan, Claudiu A.; Glöckner, Carina; Lampe, Alyssa; Difiore, Dörte; Milathianaki, Despina; Fry, Alan R.; Seibert, M. Marvin; Koglin, Jason E.; Gallo, Erik; Uhlig, Jens; Sokaras, Dimosthenis; Weng, Tsu-Chien; Zwart, Petrus H.; Skinner, David E.; Bogan, Michael J.; Messerschmidt, Marc; Glatzel, Pieter; Williams, Garth J.; Boutet, Sébastien; Adams, Paul D.; Zouni, Athina; Messinger, Johannes; Sauter, Nicholas K.; Bergmann, Uwe; Yano, Junko; Yachandra, Vittal K.

    2014-07-01

    The dioxygen we breathe is formed by light-induced oxidation of water in photosystem II. O2 formation takes place at a catalytic manganese cluster within milliseconds after the photosystem II reaction centre is excited by three single-turnover flashes. Here we present combined X-ray emission spectra and diffraction data of 2-flash (2F) and 3-flash (3F) photosystem II samples, and of a transient 3F’ state (250 μs after the third flash), collected under functional conditions using an X-ray free electron laser. The spectra show that the initial O-O bond formation, coupled to Mn reduction, does not yet occur within 250 μs after the third flash. Diffraction data of all states studied exhibit an anomalous scattering signal from Mn but show no significant structural changes at the present resolution of 4.5 Å. This study represents the initial frames in a molecular movie of the structural changes during the catalytic reaction in photosystem II.

  16. Fast Response of the Tropics to an Abrupt Loss of Arctic Sea Ice via Ocean Dynamics

    NASA Astrophysics Data System (ADS)

    Wang, Kun; Deser, Clara; Sun, Lantao; Tomas, Robert A.

    2018-05-01

    The role of ocean dynamics in the transient adjustment of the coupled climate system to an abrupt loss of Arctic sea ice is investigated using experiments with Community Climate System Model version 4 in two configurations: a thermodynamic slab mixed layer ocean and a full-depth ocean that includes both dynamics and thermodynamics. Ocean dynamics produce a distinct sea surface temperature warming maximum in the eastern equatorial Pacific, accompanied by an equatorward intensification of the Intertropical Convergence Zone and Hadley Circulation. These tropical responses are established within 25 years of ice loss and contrast markedly with the quasi-steady antisymmetric coupled response in the slab-ocean configuration. A heat budget analysis reveals the importance of anomalous vertical advection tied to a monotonic temperature increase below 200 m for the equatorial sea surface temperature warming maximum in the fully coupled model. Ocean dynamics also rapidly modify the midlatitude atmospheric response to sea ice loss.

  17. Enhancement of Exciton Emission from Multilayer MoS2 at High Temperatures: Intervalley Transfer versus Interlayer Decoupling.

    PubMed

    Li, Yuanzheng; Xu, Haiyang; Liu, Weizhen; Yang, Guochun; Shi, Jia; Liu, Zheng; Liu, Xinfeng; Wang, Zhongqiang; Tang, Qingxin; Liu, Yichun

    2017-05-01

    It is very important to obtain a deeper understand of the carrier dynamics for indirect-bandgap multilayer MoS 2 and to make further improvements to the luminescence efficiency. Herein, an anomalous luminescence behavior of multilayer MoS 2 is reported, and its exciton emission is significantly enhanced at high temperatures. Temperature-dependent Raman studies and electronic structure calculations reveal that this experimental observation cannot be fully explained by a common mechanism of thermal-expansion-induced interlayer decoupling. Instead, a new model involving the intervalley transfer of thermally activated carriers from Λ/Γ point to K point is proposed to understand the high-temperature luminescence enhancement of multilayer MoS 2 . Steady-state and transient-state fluorescence measurements show that both the lifetime and intensity of the exciton emission increase relatively to increasing temperature. These two experimental evidences, as well as a calculation of carrier population, provide strong support for the proposed model. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. Normal stresses in semiflexible polymer hydrogels

    NASA Astrophysics Data System (ADS)

    Vahabi, M.; Vos, Bart E.; de Cagny, Henri C. G.; Bonn, Daniel; Koenderink, Gijsje H.; MacKintosh, F. C.

    2018-03-01

    Biopolymer gels such as fibrin and collagen networks are known to develop tensile axial stress when subject to torsion. This negative normal stress is opposite to the classical Poynting effect observed for most elastic solids including synthetic polymer gels, where torsion provokes a positive normal stress. As shown recently, this anomalous behavior in fibrin gels depends on the open, porous network structure of biopolymer gels, which facilitates interstitial fluid flow during shear and can be described by a phenomenological two-fluid model with viscous coupling between network and solvent. Here we extend this model and develop a microscopic model for the individual diagonal components of the stress tensor that determine the axial response of semiflexible polymer hydrogels. This microscopic model predicts that the magnitude of these stress components depends inversely on the characteristic strain for the onset of nonlinear shear stress, which we confirm experimentally by shear rheometry on fibrin gels. Moreover, our model predicts a transient behavior of the normal stress, which is in excellent agreement with the full time-dependent normal stress we measure.

  19. NICER observations of highly magnetized neutron stars: Initial results

    NASA Astrophysics Data System (ADS)

    Enoto, Teruaki; Arzoumanian, Zaven; Gendreau, Keith C.; Nynka, Melania; Kaspi, Victoria; Harding, Alice; Guver, Tolga; Lewandowska, Natalia; Majid, Walid; Ho, Wynn C. G.; NICER Team

    2018-01-01

    The Neutron star Interior Composition Explorer (NICER) was launched on June 3, 2017, and attached to the International Space Station. The large effective area of NICER in soft X-rays makes it a powerful tool not only for its primary science objective (diagnostics of the nuclear equation state) but also for studying neutron stars of various classes. As one of the NICER science working groups, the Magnetars and Magnetospheres (M&M) team coordinates monitoring and target of opportunity (ToO) observations of magnetized neutron stars, including magnetars, high-B pulsars, X-ray dim isolated neutron stars, and young rotation-powered pulsars. The M&M working group has performed simultaneous X-ray and radio observations of the Crab and Vela pulsars, ToO observations of the active anomalous X-ray pulsar 4U 0142+61, and a monitoring campaign for the transient magnetar SGR 0501+4516. Here we summarize the current status and initial results of the M&M group.

  20. The excess infrared emission of Herbig Ae/Be stars - Disks or envelopes?

    NASA Technical Reports Server (NTRS)

    Hartmann, Lee; Kenyon, Scott J.; Calvet, Nuria

    1993-01-01

    It is suggested that the near-IR emission in many Herbig Ae/Be stars arises in surrounding dusty envelopes, rather than circumstellar disks. It is shown that disks around Ae/Be stars are likely to remain optically thick at the required accretion rates. It is proposed that the IR excesses of many Ae/Be stars originate in surrounding dust nebulae instead of circumstellar disks. It is suggested that the near-IR emission of the envelope is enhanced by the same processes that produce anomalous strong continuum emission at temperatures of about 1000 K in reflection nebulae surrounding hot stars. This near-IR emission could be due to small grains transiently heated by UV photons. The dust envelopes could be associated with the primary star or a nearby companion star. Some Ae/Be stars show evidence for the 3.3-6.3-micron emission features seen in reflection nebulae around hot stars, which lends further support to this suggestion.

  1. A Fluid Pulse on the Hikurangi Subduction Margin: Evidence From a Heat Flux Transect Across the Upper Limit of Gas Hydrate Stability

    NASA Astrophysics Data System (ADS)

    Pecher, I. A.; Villinger, H.; Kaul, N.; Crutchley, G. J.; Mountjoy, J. J.; Huhn, K.; Kukowski, N.; Henrys, S. A.; Rose, P. S.; Coffin, R. B.

    2017-12-01

    A transect of seafloor heat probe measurements on the Hikurangi Margin shows a significant increase of thermal gradients upslope of the updip limit of gas hydrate stability at the seafloor. We interpret these anomalously high thermal gradients as evidence for a fluid pulse leading to advective heat flux, while endothermic cooling from gas hydrate dissociation depresses temperatures in the hydrate stability field. Previous studies predict a seamount on the subducting Pacific Plate to cause significant overpressure beneath our study area, which may be the source of the fluid pulse. Double-bottom simulating reflections are present in our study area and likely caused by uplift based on gas hydrate phase boundary considerations, although we cannot exclude a thermogenic origin. We suggest that uplift may be associated with the leading edge of the subducting seamount. Our results provide further evidence for the transient nature of fluid expulsion in subduction zones.

  2. The search for Infrared radiation prior to major earthquakes

    NASA Astrophysics Data System (ADS)

    Ouzounov, D.; Taylor, P.; Pulinets, S.

    2004-12-01

    This work describes our search for a relationship between tectonic stresses and electro-chemical and thermodynamic processes in the Earth and increases in mid-IR flux as part of a possible ensemble of electromagnetic (EM) phenomena that may be related to earthquake activity. Recent analysis of continuous ongoing long- wavelength Earth radiation (OLR) indicates significant and anomalous variability prior to some earthquakes. The cause of these anomalies is not well understood but could be the result of a triggering by an interaction between the lithosphere-hydrosphere and atmospheric related to changes in the near surface electrical field and gas composition prior to the earthquake. The OLR anomaly covers large areas surrounding the main epicenter. We have use the NOAA IR data to differentiate between the global and seasonal variability and these transient local anomalies. Indeed, on the basis of a temporal and spatial distribution analysis, an anomaly pattern is found to occur several days prior some major earthquakes. The significance of these observations was explored using data sets of some recent worldwide events.

  3. Methane seeps along boundaries of arctic permafrost thaw and melting glaciers

    NASA Astrophysics Data System (ADS)

    Anthony, P.; Walter Anthony, K. M.; Grosse, G.; Chanton, J.

    2014-12-01

    Methane, a potent greenhouse gas, accumulates in subsurface hydrocarbon reservoirs. In the Arctic, impermeable icy permafrost and glacial overburden form a 'cryosphere cap' that traps gas leaking from these reservoirs, restricting flow to the atmosphere. We document the release of geologic methane to the atmosphere from abundant gas seeps concentrated along boundaries of permafrost thaw and receding glaciers in Alaska. Through aerial and ground surveys we mapped >150,000 seeps identified as bubbling-induced open holes in lake ice. Subcap methane seeps had anomalously high fluxes, 14C-depletion, and stable isotope values matching known coalbed and thermogenic methane accumulations in Alaska. Additionally, we observed younger subcap methane seeps in Greenland that were associated with ice-sheet retreat since the Little Ice Age. These correlations suggest that in a warming climate, continued disintegration of permafrost, glaciers, and parts of the polar ice sheets will relax pressure on subsurface seals and further open conduits, allowing a transient expulsion of geologic methane currently trapped by the cryosphere cap.

  4. The Electron Diffusion Region: Forces and Currents

    NASA Technical Reports Server (NTRS)

    Hesse, Michael

    2008-01-01

    The dissipation mechanism of magnetic reconnection remains a subject of intense scientific interest. On one hand, one set of recent studies have shown that particle inertia-based processes, which include thermal and bulk inertial effects, provide the reconnection electric field in the diffusion region. On the other hand, a second set of studies emphasizes the role of wave-particle interactions in providing anomalous resistivity in the diffusion region. In this presentation, we present analytical theory results, as well as PIC simulations of guide-field magnetic reconnection. We will show that the thermal electron inertia-based dissipation mechanism, expressed through nongyrotropic electron pressure tensors, remains viable in three dimensions. We will demonstrate the thermal inertia effect through studies of electron distribution functions. Furthermore, we will show that the reconnection electric field provides a transient acceleration on particles traversing the inner reconnection region. This inertia1 effect can be described as a diffusion-like term of the current density, which matches key features of electron distribution functions.

  5. The Electron Diffusion Region: Forces and Currents

    NASA Technical Reports Server (NTRS)

    Hesse, Michael

    2009-01-01

    The dissipation mechanism of magnetic reconnection remains a subject of intense scientific interest. On one hand, one set of recent studies have shown that particle inertia-based processes, which include thermal and bulk inertial effects, provide the reconnection electric field in the diffusion region. On the other hand, a second set of studies emphasizes the role of wave-particle interactions in providing anomalous resistivity in the diffusion region. In this presentation, we present analytical theory results, as well as PIC simulations of guide-field magnetic reconnection. We will show that the thermal electron inertia-based dissipation mechanism, expressed through nongyrotropic electron pressure tensors, remains viable in three dimensions. We will demonstrate the thermal inertia effect through studies of electron distribution functions. Furthermore, we will show that the reconnection electric field provides a transient acceleration on particles traversing the inner reconnection region. This inertial effect can be described as a diffusion-like term of the current density, which matches key features of electron distribution functions.

  6. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Choi, Hyun-Sik; Jeon, Sanghun, E-mail: jeonsh@korea.ac.kr

    Upon light exposure, an indium-zinc-oxide (IZO) thin-film transistor (TFT) presents higher photoconductivity by several orders of magnitude at the negative gate bias region. Among various device geometrical factors, scaling down the channel length of the photo-transistor results in an anomalous increase in photoconductivity. To probe the origin of this high photoconductivity in short-channel device, we measured transient current, current–voltage, and capacitance–voltage characteristics of IZO–TFTs with various channel lengths and widths before and after illumination. Under the illumination, the equilibrium potential region which lies far from front interface exists only in short-channel devices, forming the un-depleted conducting back channel. This regionmore » plays an important role in carrier transport under the illumination, leading to high photoconductivity in short-channel devices. Photon exposure coupled with gate-modulated band bending for short-channel devices leads to the accumulation of V{sub o}{sup ++} at the front channel and screening negative gate bias, thereby generating high current flow in the un-depleted back-channel region.« less

  7. Solar thermal vacuum tests of Magellan spacecraft

    NASA Technical Reports Server (NTRS)

    Neuman, James C.

    1990-01-01

    The Magellen solar/thermal/vacuum test involved a number of unique requirements and approaches. Because of the need to operate in orbit around Venus, the solar intensity requirement ranged up to 2.3 suns or Earth equivalent solar constants. Extensive modification to the solar simulator portion of the test facility were required to achieve this solar intensity. Venus albedo and infrared emission were simulated using temperature controlled movable louver panels to allow the spacecraft to view either a selectable temperature black heat source with closed louvers, or the chamber coldwall behind open louvers. The test conditions included widely varying solar intensities, multiple sun angles, alternate hardware configurations, steady state and transient cases, and cruise and orbital power profiles. Margin testing was also performed, wherein supplemental heaters were mounted to internal thermal blankets to verify spacecraft performance at higher than expected temperatures. The test was successful, uncovering some spacecraft anomalies and verifying the thermal design. The test support equipment experienced some anomalous behavior and a significant failure during the test.

  8. Accessibility of LDI saturated by electron trapping

    NASA Astrophysics Data System (ADS)

    Russell, David; Rose, Harvey A.

    2000-10-01

    The fact that trapped electrons, by flattening the distribution function near a Langmuir wave’s (LW’s) phase velocity, can reduce the damping of that wave, is well known. It has been predicted that this will lead to a reduction of the LDI threshold. Simulations and quasi-analytic theory have shown that this is the case, but not as has been previously suggested^1 because in general the LW response is slightly nonresonant and this departure from resonance can be as important as damping corrections to Vlasov dynamics^2. Detailed calculations of periodic solutions arising from the nonlinear evolution of the LDI, their stability, and dynamic transients, will be presented. The dependence of the nonlinear LDI threshold on the value of kλ D for the parent LW, together with loss of resonance limits on the LW amplitude, are translated into an LDI accessibility domain in the density temperature plane for backscatter SRS. 1. D. Mourenas, Phys. Plasmas 6, 1258 (1999). 2. H. A. Rose, 30th Anomalous Absorption Conference, 2000.

  9. Use of MAGSAT anomaly data for crustal structure and mineral resources in the US Midcontinent

    NASA Technical Reports Server (NTRS)

    Carmichael, R. S. (Principal Investigator)

    1981-01-01

    The analysis and preliminary interpretation of investigator-B MAGSAT data are addressed. The data processing included: (1) removal of spurious data points; (2) statistical smoothing along individual data tracks, to reduce the effect of geomagnetic transient disturbances; (3) comparison of data profiles spatially coincident in track location but acquired at different times; (4) reduction of data by weighted averaging to a grid with 1 deg xl deg latitude/longitude spacing, and with elevations interpolated and weighted to a common datum of 400 km; (5) wavelength filtering; and (6) reduction of the anomaly map to the magnetic pole. Agreement was found between a magnitude data anomaly map and a reduce-to-the-pole map supporting the general assumption that, on a large scale (long wavelength), it is induced crustal magnetization which is responsible for major anamalies. Anomalous features are identified and explanations are suggested with regard to crustal structure, petrologic characteristics, and Curie temperature isotherms.

  10. Antipodal Magnetic Anomalies on the Moon, Contributions from Impact Induced Currents Due to Positive Holes and Flexoelectric Phenomina and Dynamo

    NASA Technical Reports Server (NTRS)

    Kletetschka, G.; Freund, F.; Wasilewski, P. J.; Mikula, V.; Kohout, Tomas

    2005-01-01

    Large impacts on the Moon generate large pressure pulses that penetrate the whole body. Several of these large impacts may have generated antipodal structure with anomalous magnetic intensity.These regions can be more than a thousand km across, with fields of the order of tens to hundreds of nT. This is the case of Orientale, Imbrium, Serenitatis, Crisium, and Nectaris impact basins. The production of large-scale magnetic fields and associated crustal magnetization due to lunar basin-forming impacts was hypothesized to have an origin in fields external to the impact plasma cloud that are produced by the magnetohydrodynamic interaction of the cloud with ambient magnetic fields and plasmas. During the period of compressed antipodal field amplification, seismic compressional waves from the impact converge at the antipode resulting in transient shock pressures that reach 2 GPa (20 kbar). This can produce conditions for shock magnetic acquisition of the crust antipodal to impact basins.

  11. An alternative theoretical model for an anomalous hollow beam.

    PubMed

    Cai, Yangjian; Wang, Zhaoying; Lin, Qiang

    2008-09-15

    An alternative and convenient theoretical model is proposed to describe a flexible anomalous hollow beam of elliptical symmetry with an elliptical solid core, which was observed in experiment recently (Phys. Rev. Lett, 94 (2005) 134802). In this model, the electric field of anomalous hollow beam is expressed as a finite sum of elliptical Gaussian modes. Flattopped beams, dark hollow beams and Gaussian beams are special cases of our model. Analytical propagation formulae for coherent and partially coherent anomalous hollow beams passing through astigmatic ABCD optical systems are derived. Some numerical examples are calculated to show the propagation and focusing properties of coherent and partially coherent anomalous hollow beams.

  12. Mechanisms of the anomalous Pockels effect in bulk water

    NASA Astrophysics Data System (ADS)

    Yukita, Shunpei; Suzuki, Yuto; Shiokawa, Naoyuki; Kobayashi, Takayoshi; Tokunaga, Eiji

    2018-04-01

    The "anomalous" Pockels effect is a phenomenon that a light beam passing between two electrodes in an aqueous electrolyte solution is deflected by an AC voltage applied between the electrodes: the deflection angle is proportional to the voltage such that the incident beam alternately changes its direction. This phenomenon, the Pockels effect in bulk water, apparently contradicts what is believed in nonlinear optics, i.e., macroscopic inversion symmetry should be broken for the second-order nonlinear optical effect to occur such as the first-order electro-optic effect, i.e., the Pockels effect. To clarify the underlying mechanism, the dependence of the effect on the electrode material is investigated to find that the Pockels coefficient with Pt electrodes is two orders of magnitude smaller than with indium tin oxide (ITO) electrodes. It is experimentally confirmed that the Pockels effect of interfacial water in the electric double layer (EDL) on these electrodes shows an electrode dependence similar to the effect in bulk water while the effects depend on the frequency of the AC voltage such that the interfacial signal decreases with frequency but the bulk signal increases with frequency up to 221 Hz. These experimental results lead to a conclusion that the beam deflection is caused by the refractive index gradient in the bulk water region, which is formed transiently by the Pockels effect of interfacial water in the EDL when an AC electric field is applied. The refractive index gradient is caused by the diffuse layer spreading into the bulk region to work as a breaking factor of inversion symmetry of bulk water due to its charge-biased ionic distribution. This mechanism does not contradict the principle of nonlinear optics.

  13. Classification and unsupervised clustering of LIGO data with Deep Transfer Learning

    NASA Astrophysics Data System (ADS)

    George, Daniel; Shen, Hongyu; Huerta, E. A.

    2018-05-01

    Gravitational wave detection requires a detailed understanding of the response of the LIGO and Virgo detectors to true signals in the presence of environmental and instrumental noise. Of particular interest is the study of anomalous non-Gaussian transients, such as glitches, since their occurrence rate in LIGO and Virgo data can obscure or even mimic true gravitational wave signals. Therefore, successfully identifying and excising these anomalies from gravitational wave data is of utmost importance for the detection and characterization of true signals and for the accurate computation of their significance. To facilitate this work, we present the first application of deep learning combined with transfer learning to show that knowledge from pretrained models for real-world object recognition can be transferred for classifying spectrograms of glitches. To showcase this new method, we use a data set of twenty-two classes of glitches, curated and labeled by the Gravity Spy project using data collected during LIGO's first discovery campaign. We demonstrate that our Deep Transfer Learning method enables an optimal use of very deep convolutional neural networks for glitch classification given small and unbalanced training data sets, significantly reduces the training time, and achieves state-of-the-art accuracy above 98.8%, lowering the previous error rate by over 60%. More importantly, once trained via transfer learning on the known classes, we show that our neural networks can be truncated and used as feature extractors for unsupervised clustering to automatically group together new unknown classes of glitches and anomalous signals. This novel capability is of paramount importance to identify and remove new types of glitches which will occur as the LIGO/Virgo detectors gradually attain design sensitivity.

  14. Inflight Performance of Cassini Reaction Wheel Bearing Drag in 1997-2013

    NASA Technical Reports Server (NTRS)

    Lee, Allan Y.; Wang, Eric K.

    2013-01-01

    As the first spacecraft to achieve orbit at Saturn in 2004, Cassini has collected science data throughout its four-year prime mission (2004-08), and has since been approved for a first and second extended missions through September 2017. Cassini is a three-axis stabilized spacecraft. It uses reaction wheels to achieve high level of spacecraft pointing stability that is needed during imaging operations of several science instruments. The Cassini flight software makes in-flight estimates of reaction wheel bearing drag torque and made them available to the mission operations team. These telemetry data are being trended for the purpose of monitoring the long-term health of the reaction wheel bearings. Anomalous drag torque signatures observed over the past 15 years are described in this paper. One of these anomalous drag conditions is bearing cage instability that appeared (and disappeared) spontaneously and unpredictably. Cage instability is an uncontrolled vibratory motion of the bearing cage that can produce high-impact forces internal to the bearing that will cause intermittent and erratic torque transients. Characteristics of the observed cage instabilities and other drag torque "spikes" are described in this paper. In day-to-day operations, the reaction wheels' rates must be neither too high nor too low. To protect against operating the wheels in any undesirable conditions (such as prolonged low spin rate operations), a ground software tool named Reaction Wheel Bias Optimization Tool (RBOT) was developed for the management of the wheels. Disciplined and long-term use of this ground software has led to significant reduction in the daily consumption rate of the wheels' low spin rate dwell time. Flight experience on the use of this ground software tool as well as other lessons learned on the management of Cassini reaction wheels is given in this paper.

  15. Structural changes in the vascular bundles of light-exposed and shaded spruce needles suffering from Mg deficiency and ozone pollution.

    PubMed

    Boxler-Baldoma, Carmen; Lütz, Cornelius; Heumann, Hans-Günther; Siefermann-Harms, Dorothea

    2006-02-01

    The correlation between structural changes of the vascular bundles and needle yellowing was examined for needles of damaged spruce (Picea abies (L.) Karst.) growing at a Mg-deficient and ozone polluted mountain site in the Central Black Forest (840m a.s.l.). In the previous year's sun-exposed needles, the following sequence of events was observed: (1) rapid needle yellowing, (2) hypertrophy and anomalous divisions of cambium cells, (3) phloem collapse, and, (4) production of atypical xylem tracheids. Under defined shade (reduction of the photosynthetically active photon flux density of the ambient light by 85-90%), the needles remained green, while the phloem collapsed completely within the first 6 weeks of shading; subsequently, a reversal of the collapse was observed. Under both light conditions, the content of Mg not bound to chlorophyll (Mg(free)) was in the range of 0.1 mg g(-1) needle dry matter, and hardly changed throughout the investigation period. After Mg fertilization, the Mg(free) level of the previous year's needles increased to 0.2 mg g(-1) dry matter, the light-exposed needles remained green, and the vascular bundles developed no anomalies. The data show that the rapid needle yellowing of ozone-exposed Mg-deficient needles did not depend on the collapse of the phloem. Mg deficiency played a key role in the development of anomalous vascular bundles under light, and also appears to explain the transient changes in sieve cell structure under shade. The role of Mg deficiency, rather than ozone pollution, in the damage of the sieve cells was confirmed in a long-term ozone exposure experiment with young clonal spruce growing under defined conditions.

  16. Theory and modeling of particles with DNA-mediated interactions

    NASA Astrophysics Data System (ADS)

    Licata, Nicholas A.

    In recent years significant attention has been attracted to proposals which utilize DNA for nanotechnological applications. Potential applications of these ideas range from the programmable self-assembly of colloidal crystals, to biosensors and nanoparticle based drug delivery platforms. In Chapter I we introduce the system, which generically consists of colloidal particles functionalized with specially designed DNA markers. The sequence of bases on the DNA markers determines the particle type. Due to the hybridization between complementary single-stranded DNA, specific, type-dependent interactions can be introduced between particles by choosing the appropriate DNA marker sequences. In Chapter II we develop a statistical mechanical description of the aggregation and melting behavior of particles with DNA-mediated interactions. A quantitative comparison between the theory and experiments is made by calculating the experimentally observed melting profile. In Chapter III a model is proposed to describe the dynamical departure and diffusion of particles which form reversible key-lock connections. The model predicts a crossover from localized to diffusive behavior. The random walk statistics for the particles' in plane diffusion is discussed. The lateral motion is analogous to dispersive transport in disordered semiconductors, ranging from standard diffusion with a renormalized diffusion coefficient to anomalous, subdiffusive behavior. In Chapter IV we propose a method to self-assemble nanoparticle clusters using DNA scaffolds. An optimal concentration ratio is determined for the experimental implementation of our self-assembly proposal. A natural extension is discussed in Chapter V, the programmable self-assembly of nanoparticle clusters where the desired cluster geometry is encoded using DNA-mediated interactions. We determine the probability that the system self-assembles the desired cluster geometry, and discuss the connections to jamming in granular and colloidal systems. In Chapter VI we consider a nanoparticle based drug delivery platform for targeted, cell specific chemotherapy. A key-lock model is proposed to describe the results of in-vitro experiments, and the situation in-vivo is discussed. The cooperative binding, and hence the specificity to cancerous cells, is kinetically limited. The implications for optimizing the design of nanoparticle based drug delivery platforms is discussed. In Chapter VII we present prospects for future research: the connection between DNA-mediated colloidal crystallization and jamming, and the inverse problem in self-assembly.

  17. Tunable anisotropic anomalous Nernst effect and orbital magnetization in Floquet Weyl semimetals

    NASA Astrophysics Data System (ADS)

    Niu, Zhi Ping; Wu, Xueshi

    2018-03-01

    Weyl semimetals and nodal line semimetals display a host of novel properties. Floquet Weyl semimetals with tunable Weyl points can be obtained from nodal line semimetals under the circularly polarized off-resonant light. Here we theoretically investigate the anomalous Nernst effect and orbital magnetization in Floquet Weyl semimetals. Due to the anisotropy of the band structure in Floquet Weyl semimetals, highly anisotropic Berry phase mediated anomalous Nernst effect and orbital magnetization in the absence of magnetic field are observed, indicating orientation-dependent applications in the design of nanodevices. The amplitude and sign of anomalous Nernst coefficient and orbital magnetization can be tuned by the light direction, amplitude and polarization. The effect of the chemical potential on anomalous Nernst coefficient and orbital magnetization is also discussed. The light-modulated anomalous Nernst effect and orbital magnetization make Floquet Weyl semimetals potential candidates for thermoelectric devices.

  18. Macromolecular crowding impacts on the diffusion and conformation of DNA hairpins

    NASA Astrophysics Data System (ADS)

    Stiehl, Olivia; Weidner-Hertrampf, Kathrin; Weiss, Matthias

    2015-01-01

    Biochemical reactions in crowded fluids differ significantly from those in dilute solutions. Both, excluded-volume interactions with surrounding macromolecules ("crowders") and an enhanced rebinding of reaction partners due to crowding-induced viscoelasticity and subdiffusion have been hypothesized to shift chemical equilibria towards the associated state. We have explored the impact of both cues in an experimentally tunable system by monitoring the steady-state fraction of open DNA hairpins in crowded fluids with varying viscoelastic characteristics but similar occupied volume fractions. As a result, we observed an increased fraction of closed DNA hairpins in viscoelastic crowded fluids. Our observations compare favorably to a simple statistical model that considers both facets of crowding, while preferential interactions between crowders and DNA hairpins appear to have little influence.

  19. Brownian Motion of Asymmetric Boomerang Colloidal Particles

    NASA Astrophysics Data System (ADS)

    Chakrabarty, Ayan; Konya, Andrew; Wang, Feng; Selinger, Jonathan; Sun, Kai; Wei, Qi-Huo

    2014-03-01

    We used video microscopy and single particle tracking to study the diffusion and local behaviors of asymmetric boomerang particles in a quasi-two dimensional geometry. The motion is biased towards the center of hydrodynamic stress (CoH) and the mean square displacements of the particles are linear at short and long times with different diffusion coefficients and in the crossover regime it is sub-diffusive. Our model based on Langevin theory shows that these behaviors arise from the non-coincidence of the CoH with the center of the body. Since asymmetric boomerangs represent a class of rigid bodies of more generals shape, therefore our findings are generic and true for any non-skewed particle in two dimensions. Both experimental and theoretical results will be discussed.

  20. Anomalous magnon Nernst effect of topological magnonic materials

    NASA Astrophysics Data System (ADS)

    Wang, X. S.; Wang, X. R.

    2018-05-01

    The magnon transport driven by a thermal gradient in a perpendicularly magnetized honeycomb lattice is studied. The system with the nearest-neighbor pseudodipolar interaction and the next-nearest-neighbor Dzyaloshinskii–Moriya interaction has various topologically nontrivial phases. When an in-plane thermal gradient is applied, a transverse in-plane magnon current is generated. This phenomenon is termed as the anomalous magnon Nernst effect that closely resembles the anomalous Nernst effect for an electronic system. The anomalous magnon Nernst coefficient and its sign are determined by the magnon Berry curvature distributions in the momentum space and magnon populations in the magnon bands. We predict a temperature-induced sign reversal in anomalous magnon Nernst effect under certain conditions.

  1. Crystallographic Phasing from Weak Anomalous Signals

    PubMed Central

    Liu, Qun; Hendrickson, Wayne A.

    2015-01-01

    The exploitation of anomalous signals for biological structural solution is maturing. Single-wavelength anomalous diffraction (SAD) is dominant in de novo structure analysis. Nevertheless, for challenging structures where the resolution is low (dmin ≥ 3.5 Å) or where only lighter atoms (Z ≤ 20) are present, as for native macromolecules, solved SAD structures are still scarce. With the recent rapid development in crystal handling, beamline instrumentation, optimization of data collection strategies, use of multiple crystals and structure determination technologies, the weak anomalous diffraction signals are now robustly measured and should be used for routine SAD structure determination. The review covers these recent advances on weak anomalous signals measurement, analysis and utilization. PMID:26432413

  2. Crystallographic phasing from weak anomalous signals.

    PubMed

    Liu, Qun; Hendrickson, Wayne A

    2015-10-01

    The exploitation of anomalous signals for biological structural solution is maturing. Single-wavelength anomalous diffraction (SAD) is dominant in de novo structure analysis. Nevertheless, for challenging structures where the resolution is low (dmin≥3.5Å) or where only lighter atoms (Z≤20) are present, as for native macromolecules, solved SAD structures are still scarce. With the recent rapid development in crystal handling, beamline instrumentation, optimization of data collection strategies, use of multiple crystals and structure determination technologies, the weak anomalous diffraction signals are now robustly measured and should be used for routine SAD structure determination. The review covers these recent advances on weak anomalous signals measurement, analysis and utilization. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. Tellurium - Should it be isotopically anomalous in the Allende meteorite

    NASA Technical Reports Server (NTRS)

    Heymann, D.; Dziczkaniec, M.

    1981-01-01

    Isotopically anomalous Te is a by-product of the nuclear processes in zones of supernovae that have been proposed as sources for isotopically anomalous Xe. The calculated composition of the anomalous Te is roughly consistent with the disputed measurements made by Ballad et at. (1979) and Oliver et al. (1979) of samples of the Allende meteorite, with the exception that the large Te-123 overabundance reported by Oliver et al. (1979) is not predicted by the theory.

  4. Percutaneous intervention of chronic total occlusion of anomalous right coronary artery originating from left sinus – Use of mother and child technique using guideliner

    PubMed Central

    Senguttuvan, Nagendra Boopathy; Sharma, Samin K.; Kini, Annapoorna

    2015-01-01

    Anomalous origin of right coronary artery (RCA) from left sinus is a rare clinical entity. Percutaneous coronary intervention of such an anomalous RCA, which is chronically occluded, is difficult and is rarely described. We describe such an intervention in a patient, who had a chronic total occlusion of anomalous RCA and discuss the technical issues associated with such interventions. PMID:26995429

  5. Endovascular repair of abdominal aortic aneurysms in patients with congenital renal vascular anomalies.

    PubMed

    Kaplan, D B; Kwon, C C; Marin, M L; Hollier, L H

    1999-09-01

    The endovascular repair of abdominal aortic aneurysms (AAAs) has been suggested as an alternative to conventional aortic reconstruction. The presence of anomalous renal vascular anatomy frequently necessitates special planning during conventional aortic replacement and may also create unique challenges for endovascular repair. We analyzed our experience with 24 patients with variant renal vascular anatomies who underwent treatment with aortic endografts to determine the safety and efficacy of this technique in this population. During a 6-year period, 204 patients underwent aortic endograft procedures, 24 (11.8%) of whom had variations in renal vascular anatomy. There were 19 men and five women. Each of the 24 patients had variant renal vascular anatomy, which was defined by the presence of multiple renal arteries (n = 32), with or without a renal parenchymal anomaly (horseshoe or solitary pelvic kidney). Twenty patients underwent aneurysm repair with balloon expandable polytetrafluoroethylene grafts, and the remaining patients underwent endograft placement with self-expanding attachment systems. Eighteen patients underwent exclusion and presumed thrombosis of anomalous renal branches to effectively attach the aortic endograft. The decision to sacrifice a supernumerary artery was made on the basis of the vessel size (<3 mm), the absence of coexisting renal insufficiency, and the expectation for successful aneurysm exclusion. The successful exclusion of the AAAs was achieved in all the patients, with the loss of a total of 17 renal artery branches in 12 patients. Small segmental renal infarcts (<20%) were detected in only six of the 12 patients with follow-up computed tomographic scan results, despite angiographic evidence of vessel occlusion at the time of endografting. No evidence of new onset hypertension or changes in antihypertensive medication was seen in this group. No retrograde endoleaks were detected through the excluded renal branches on late follow-up computed tomographic scans. Serum creatinine levels before and after endografting were unchanged after the exclusion of the AAA in all but one patient with multiple renal branches. One patient had a transient rise in serum creatinine level presumed to be caused by contrast nephropathy. On the basis of this experience, we recommend the consideration of endovascular grafting for patients with AAAs and anomalous renal vessels when the main renal vascular anatomy can be preserved and when the loss of only small branches (<3 mm) is necessitated in patients with otherwise normal renal functions.

  6. Diagnosing Mechanisms of Oceanic Influence on Sahel Precipitation Variability

    NASA Astrophysics Data System (ADS)

    Pomposi, Catherine A.

    The West African Monsoon (WAM) is a significant component of the global monsoon system and plays a key role in the annual cycle of precipitation in the Sahel region of Africa (10°N to 20°N) during the summer months (July to September). Rainfall in the Sahel varies on timescales ranging from seasons to millennia as a result of changes in the WAM. In the last century, the Sahel experienced a relatively wet period (prior to the 1960s) followed by a period of severe drought (1970s-1980s) with higher-frequency variability superimposed on this low-frequency background signal. Understanding precipitation variability like that which occurred over the 20th Century and its impact on Sahel precipitation is critically important for skillful hydroclimate predictions and disaster preparedness in the region. Previous work has shown that the WAM responds to both internal atmospheric variability and external oceanic forcing. A large fraction of 20th Century Sahel rainfall variability has been linked to nearby and remote oceanic forcing from the Atlantic, Pacific, and Indian Oceans, suggesting that the ocean is the primary driver of variability. However, the mechanisms underlying the influence of sea surface temperature (SST) forcing to land based precipitation and the relative importance of the roles of different basins are not as well understood. To this end, the work completed in this thesis examines the physical mechanisms linking oceanic forcing to recent precipitation variability in the Sahel and identifies them alongside large-scale environmental conditions. A series of moisture budget decomposition studies are performed for the Sahel in order to understand the processes that govern regional hydroclimate variability on decadal and interannual time scales. The results show that the oceanic forcing of atmospheric mass convergence and divergence explains the moisture balance patterns in the region to first order on the timescales considered. On decadal timescales, forcing by the Indian and Atlantic Oceans correlate strongly with precipitation variability. The combination of a warm Indian Ocean and negative gradient across the Atlantic forces anomalous circulation patterns that result in net moisture divergence by the mean and transient flow. Together with negative moisture advection, these processes result in a strong drying of the Sahel during the later part of the 20th Century. Diagnosis of moisture budget and circulation components within the main rainbelt and along the monsoon margins show that changes to the mass convergence are related to the magnitude of precipitation that falls in the region, while the advection of dry air is associated with the maximum latitudinal extent of precipitation. On interannual timescales, results show that warm conditions in the Eastern Tropical Pacific remotely force anomalously dry conditions primarily through affecting the low-troposphere mass divergence field. This behavior is related to increased subsidence over the tropical Atlantic and into the Sahel and an anomalous westward flow of moisture from the continent, both resulting in a coherent drying pattern. The interannual signal is then further explored, particularly in light of the expected link between the El Nino Southern Oscillation and dry conditions in the Sahel, notably unseen during the historic El Nino event of 2015. Motivated by this, recent El Nino years and their precipitation signature in the Sahel along with the associated large-scale environmental conditions are examined. Two different outcomes for Sahel summer season are defined; an anomalously wet or an anomalously dry season coincident with El Nino conditions. The different precipitation patterns are distinguished by increased moisture supply for the wet years, which can be driven by both regional oceanic conditions that favor increased moisture convergence over the continent as well as weaker El Nino forcing. Finally, a series of new idealized SST-forced experiments that explore the causal link between oceanic forcing and the response of convection in the region on daily time resolution are discussed and preliminary results shown. These experiments aim to understand how convection in the Sahel responds to SST forcing using transient model simulations that track the evolving response of the WAM through time, day-by-day, under different oceanic conditions. Preliminary results show the stark differences in seasonal precipitation that occur when anomalies of opposite sign are applied in parts of the Atlantic and Pacific basin. There is also a suggestion of a difference in the timing of the rainy season when the model is run with different SST configurations.

  7. An accidental geophysical discovery of an Iron Age archaeological site on the western shore of Lake Baikal

    NASA Astrophysics Data System (ADS)

    Kozhevnikov, Nikolai O.; Kharinsky, Arthur V.; Kozhevnikov, Oleg K.

    2001-06-01

    Slowly decaying transients were measured during a TEM survey over crystalline metamorphic rocks in the vicinity of the village of Chernorud, on the western shore of Lake Baikal. Once converted to apparent resistivities, these transients resulted in values of about 2-5 Ω m. Because neither in-field nor laboratory DC resistivity measurements indicate conductive rocks, the TEM results are confusing. It is hypothesized that the anomalous transients were caused by the relaxation of the magnetization of extremely fine ferri- and/or ferromagnetic particles concentrated in the near-surface layer. In 1997, in the soil thrown out of a gopher burrow, slags and charcoal fragments were found which suggested ancient metallurgical activity. Despite the slags being electrically poorly conductive, once placed into a small coil, they produced slowly decaying transients caused by magnetic viscosity effects. On the basis of their chemical and mineral composition, the Chernorud site slags proved to be identical to those which are known to have been formed during the production of iron in ancient bloomery furnaces. An excavation carried out at the site of the gopher burrow resulted in the discovery of a large bloomery furnace, much slag, charcoal, and baked clay fragments. In 1999, reconnaissance magnetic field and galvanic resistivity profiling measurements were conducted, focused on the site's archaeological potential. Data were taken over a 96×100 m area at 4 m intervals along parallel profiles spaced at 4 m. The magnetic field contour and surface maps exhibited an isometrically shaped positive anomaly with an amplitude of 40-50 nT, that was 30-40 m in diameter. The bloomery and other archaeometallurgical structures fall within the central part of the magnetic anomaly. The galvanic profiling has revealed a resistivity high (1000-1500 Ω m against 300-500 Ω m) which might be attributed to ancient human activity. Radiocarbon dating of three charcoal fragments sampled during the excavation from different depth intervals has given uncalibrated ages of 1915±35, 2050±35 and 2180±30 years BP. These results make it apparent that the Iron Age on the western shore of Lake Baikal started about 700-900 years earlier than is generally accepted. Occurrence of slags over an area of no less than 15 ha suggests that iron production in the Barun-Khal valley was performed on a large scale.

  8. Multi-instrument observations of pre-earthquake transient signatures associated with 2015 M8.3 Chile earthquake

    NASA Astrophysics Data System (ADS)

    Ouzounov, D.; Pulinets, S. A.; Hernandez-Pajares, M.; Garcia-Rigo, A.; De Santis, A.; Pavón, J.; Liu, J. Y. G.; Chen, C. H.; Cheng, K. C.; Hattori, K.; Stepanova, M. V.; Romanova, N.; Hatzopoulos, N.; Kafatos, M.

    2016-12-01

    We are conducting multi parameter validation study on lithosphere/atmosphere /ionosphere transient phenomena preceding major earthquakes particularly for the case of M8.3 of Sept 16th, 2015 in Chile. Our approach is based on monitoring simultaneously a series of different physical parameters from space: 1/Outgoing long-wavelength radiation (OLR obtained from NOAA/AVHRR); 2/ electron and electron density variations in the ionosphere via GPS Total Electron Content (GPS/TEC), and 3/geomagnetic field and plasma density variation (Swarm); and from ground: 3/ GPS crustal deformation and 4/ground-based magnetometers. The time and location of main shock was prospectively alerted in advance using the Multi Sensor Networking Approach (MSNA-LAIC) approach. We analyzed retrospectively several physical observations characterizing the state of the lithosphere, atmosphere and ionosphere several days before, during and after the M8.3 earthquakes in Illapel. Our continuous satellite monitoring of long-wave (LW) data over Chile, shows a rapid increase of emitted radiation during the end of August 2015 and an anomaly in the atmosphere was detected at 19 LT on Sept 1st, 2015, over the water near to the epicenter. On Sept 2nd Swarm magnetic measurements show an anomalous signature over the epicentral region. GPS/TEC analysis revealed an anomaly on Sept 14th and on the same day the degradation of Equatorial Ionospheric Anomaly (EIA) and disappearance of the crests of EIA as is characteristic for pre-dawn and early morning hours (11 LT) was observed. On Sept 16th co-seismic ionospheric signatures consistent with defined circular acoustic-gravity wave and different shock-acoustic waves were also observed. GPS TEC and deformation studies were computed from 48 GPS stations (2013-2015) of National Seismological Center of Chile (CSN) GPS network. A transient signal of deformation has been observed a week in advance correlated with ground-based magnetometers ULF signal fluctuation from closest to the epicenter station from the SAMBA-AMBER network. The characteristics of the observed pre-, and co - seismic transient signals associated with the M8.3 of Illapel, Chile 2015 earthquake suggested that they follow general temporal-spatial evolution pattern, which has been seen in other large earthquakes worldwide.

  9. Large anomalous Hall effect driven by a nonvanishing Berry curvature in the noncolinear antiferromagnet Mn3Ge.

    PubMed

    Nayak, Ajaya K; Fischer, Julia Erika; Sun, Yan; Yan, Binghai; Karel, Julie; Komarek, Alexander C; Shekhar, Chandra; Kumar, Nitesh; Schnelle, Walter; Kübler, Jürgen; Felser, Claudia; Parkin, Stuart S P

    2016-04-01

    It is well established that the anomalous Hall effect displayed by a ferromagnet scales with its magnetization. Therefore, an antiferromagnet that has no net magnetization should exhibit no anomalous Hall effect. We show that the noncolinear triangular antiferromagnet Mn3Ge exhibits a large anomalous Hall effect comparable to that of ferromagnetic metals; the magnitude of the anomalous conductivity is ~500 (ohm·cm)(-1) at 2 K and ~50 (ohm·cm)(-1) at room temperature. The angular dependence of the anomalous Hall effect measurements confirms that the small residual in-plane magnetic moment has no role in the observed effect except to control the chirality of the spin triangular structure. Our theoretical calculations demonstrate that the large anomalous Hall effect in Mn3Ge originates from a nonvanishing Berry curvature that arises from the chiral spin structure, and that also results in a large spin Hall effect of 1100 (ħ/e) (ohm·cm)(-1), comparable to that of platinum. The present results pave the way toward the realization of room temperature antiferromagnetic spintronics and spin Hall effect-based data storage devices.

  10. Computational Study of Anomalous Transport in High Beta DIII-D Discharges with ITBs

    NASA Astrophysics Data System (ADS)

    Pankin, Alexei; Garofalo, Andrea; Grierson, Brian; Kritz, Arnold; Rafiq, Tariq

    2015-11-01

    The advanced tokamak scenarios require a large bootstrap current fraction and high β. These large values are often outside the range that occurs in ``conventional'' tokamak discharges. The GLF23, TGLF, and MMM transport models have been previously validated for discharges with parameters associated with ``conventional'' tokamak discharges. It has been demonstrated that the TGLF model under-predicts anomalous transport in high β DIII-D discharges [A.M. Garofalo et al. 2015 TTF Workshop]. In this research, the validity of MMM7.1 model [T. Rafiq et al. Phys. Plasmas 20 032506 (2013)] is tested for high β DIII-D discharges with low and high torque. In addition, the sensitivity of the anomalous transport to β is examined. It is shown that the MMM7.1 model over-predicts the anomalous transport in the DIII-D discharge 154406. In particular, a significant level of anomalous transport is found just outside the internal transport barrier. Differences in the anomalous transport predicted using TGLF and MMM7.1 are reviewed. Mechanisms for quenching of anomalous transport in the ITB regions of high-beta discharges are investigated. This research is supported by US Department of Energy.

  11. Anomalous quartic couplings in W+W- gamma production at e+e- colliders

    NASA Astrophysics Data System (ADS)

    Leil, G. A.; Stirling, W. J.

    1995-04-01

    We study the process $e^+e^- \\rightarrow W^+W^- \\gamma$ at high-energy $e^+ e^-$ colliders to investigate the effect of genuine quartic $W^+W^-\\gamma\\gamma$ and $W^+W^- Z\\gamma$ anomalous couplings on the cross section. Deviations from the Standard Model predictions are quantified. We show how bounds on the anomalous couplings can be improved by choosing specific initial state helicity combinations. The dependence of the anomalous contributions on the collider energy is studied.

  12. Possible combined influences of absorbing aerosols and anomalous atmospheric circulation on summertime diurnal temperature range variation over the middle and lower reaches of the Yangtze River

    NASA Astrophysics Data System (ADS)

    Cai, Jiaxi; Guan, Zhaoyong; Ma, Fenhua

    2016-12-01

    Based on the temperature data from the China Meteorological Administration, NCEP-NCAR reanalysis data, and the TOMS Aerosol Index (AI), we analyze the variations in the summertime diurnal temperature range (DTR) and temperature maxima in the middle and lower reaches of the Yangtze River (MLRYR) in China. The possible relationships between the direct warming effect of the absorbing aerosol and temperature variations are further investigated, although with some uncertainties. It is found that the summertime DTR exhibits a decreasing trend over the most recent 50 years, along with a slight increasing tendency since the 1980s. The trend of the maximum temperature is in agreement with those of the DTR and the absorbing aerosols. To investigate the causes of the large anomalies in the temperature maxima, composite analyses of the circulation anomalies are performed. When anomalous AI and anomalous maximum temperature over the MLRYR have the same sign, an anomalous circulation with a quasi-barotropic structure occurs there. This anomalous circulation is modulated by the Rossby wave energy propagations from the regions northwest of the MLRYR and influences the northwestern Pacific subtropical high over the MLRYR. In combination with aerosols, the anomalous circulation may increase the maximum temperature in this region. Conversely, when the anomalous AI and anomalous maximum temperature in the MLRYR have opposite signs, the anomalous circulation is not equivalently barotropic, which possibly offsets the warming effect of aerosols on the maximum temperature changes in this region. These results are helpful for a better understanding of the DTR changes and the occurrences of temperature extremes in the MLRYR region during boreal summer.

  13. Adults with autism spectrum conditions experience increased levels of anomalous perception.

    PubMed

    Milne, Elizabeth; Dickinson, Abigail; Smith, Richard

    2017-01-01

    Autism spectrum condition (ASC) is characterised by differences in social interaction and behavioural inflexibility. In addition to these core symptoms, atypical sensory responses are prevalent in the ASC phenotype. Here we investigated anomalous perception, i.e. hallucinatory and/or out of body experiences in adults with ASC. Thirty participants with an ASC diagnosis and thirty neurotypical controls completed the Cardiff Anomalous Perception Scale (CAPS) and the Social Responsiveness Scale (SRS-2). The CAPS is a 32-item questionnaire that asks participants to indicate whether or not they experience a range of anomalous and out of body experiences, and to rate how intrusive and distressing these experiences are. The SRS-2 asks participants to rate the extent to which they identify with a series of 65 statements that describe behaviours associated with the autism phenotype. We found that total CAPS score was significantly higher in the participants with ASC (mean = 14.8, S.D. = 7.9) than the participants without ASC (mean = 3.6, S.D. = 4.1). In addition, the frequency of anomalous perception, the level of distraction and the level of distress associated with the experience were significantly increased in participants with ASC. Importantly, both the frequency of anomalous perceptual experiences and the level of distress caused by anomalous perception in this sample of adults with ASC were very similar to that reported previously in a sample of non-autistic participants who were being treated in hospital for a current psychotic episode. These data indicate that anomalous perceptual experiences are common in adults with ASC and are associated with a high level of distress. The origins of anomalous perception in ASC and the implication of this phenomenon are considered.

  14. Lévy/Anomalous Diffusion as a Mean-Field Theory for 3D Cloud Effects in SW-RT: Empirical Support, New Analytical Formulation, and Impact on Atmospheric Absorption

    NASA Astrophysics Data System (ADS)

    Pfeilsticker, K.; Davis, A.; Marshak, A.; Suszcynsky, D. M.; Buldryrev, S.; Barker, H.

    2001-12-01

    2-stream RT models, as used in all current GCMs, are mathematically equivalent to standard diffusion theory where the physical picture is a slow propagation of the diffuse radiation by Gaussian random walks. In other words, after the conventional van de Hulst rescaling by 1/(1-g) in R3 and also by (1-g) in t, solar photons follow convoluted fractal trajectories in the atmosphere. For instance, we know that transmitted light is typically scattered about (1-g)τ 2 times while reflected light is scattered on average about τ times, where τ is the optical depth of the column. The space/time spread of this diffusion process is described exactly by a Gaussian distribution; from the statistical physics viewpoint, this follows from the convergence of the sum of many (rescaled) steps between scattering events with a finite variance. This Gaussian picture follows from directly from first principles (the RT equation) under the assumptions of horizontal uniformity and large optical depth, i.e., there is a homogeneous plane-parallel cloud somewhere in the column. The first-order effect of 3D variability of cloudiness, the main source of scattering, is to perturb the distribution of single steps between scatterings which, modulo the '1-g' rescaling, can be assumed effectively isotropic. The most natural generalization of the Gaussian distribution is the 1-parameter family of symmetric Lévy-stable distributions because the sum of many zero-mean random variables with infinite variance, but finite moments of order q < α (0 < α < 2), converge to them. It has been shown on heuristic grounds that for these Lévy-based random walks the typical number of scatterings is now (1-g)τ α for transmitted light. The appearance of a non-rational exponent is why this is referred to as anomalous diffusion. Note that standard/Gaussian diffusion is retrieved in the limit α = 2-. Lévy transport theory has been successfully used in the statistical physics to investigate a wide variety of systems with strongly nonlinear dynamics; these applications range from random advection in turbulent fluids to the erratic behavior of financial time-series and, most recently, self-regulating ecological systems. We will briefly survey the state-of-the-art observations that offer compelling empirical support for the Lévy/anomalous diffusion model in atmospheric radiation: (1) high-resolution spectroscopy of differential absorption in the O2 A-band from ground; (2) temporal transient records of lightning strokes transmitted through clouds to a sensitive detector in space; and (3) the Gamma-distributions of optical depths derived from Landsat cloud scenes at 30-m resolution. We will then introduce a rigorous analytical formulation of anomalous transport through finite media based on fractional derivatives and Sonin calculus. A remarkable result from this new theoretical development is an extremal property of the α = 1+ case (divergent mean-free-path), as is observed in the cloudy atmosphere. Finally, we will discuss the implications of anomalous transport theory for bulk 3D effects on the current enhanced absorption problem as well as its role as the basis of a next-generation GCM RT parameterization.

  15. Anomalous Diffraction in Crystallographic Phase Evaluation

    PubMed Central

    Hendrickson, Wayne A.

    2014-01-01

    X-ray diffraction patterns from crystals of biological macromolecules contain sufficient information to define atomic structures, but atomic positions are inextricable without having electron-density images. Diffraction measurements provide amplitudes, but the computation of electron density also requires phases for the diffracted waves. The resonance phenomenon known as anomalous scattering offers a powerful solution to this phase problem. Exploiting scattering resonances from diverse elements, the methods of multiwavelength anomalous diffraction (MAD) and single-wavelength anomalous diffraction (SAD) now predominate for de novo determinations of atomic-level biological structures. This review describes the physical underpinnings of anomalous diffraction methods, the evolution of these methods to their current maturity, the elements, procedures and instrumentation used for effective implementation, and the realm of applications. PMID:24726017

  16. Anomalous pulmonary venous connection: An underestimated entity.

    PubMed

    Magalhães, Sara P; Moreno, Nuno; Loureiro, Marília; França, Manuela; Reis, Fernanda; Alvares, Sílvia; Ribeiro, Manuel

    2016-12-01

    Anomalous pulmonary venous connection is an uncommon congenital anomaly in which all (total form) or some (partial form) pulmonary veins drain into a systemic vein or into the right atrium rather than into the left atrium. The authors present one case of total anomalous pulmonary venous connection and two cases of partial anomalous pulmonary venous connection, one of supracardiac drainage into the brachiocephalic vein, and the other of infracardiac anomalous venous drainage (scimitar syndrome). Through the presentation of these cases, this article aims to review the main pulmonary venous developmental defects, highlighting the role of imaging techniques in the assessment of these anomalies. Copyright © 2016 Sociedade Portuguesa de Cardiologia. Publicado por Elsevier España, S.L.U. All rights reserved.

  17. Anomalous incident-angle and elliptical-polarization rotation of an elastically refracted P-wave

    NASA Astrophysics Data System (ADS)

    Fa, Lin; Fa, Yuxiao; Zhang, Yandong; Ding, Pengfei; Gong, Jiamin; Li, Guohui; Li, Lijun; Tang, Shaojie; Zhao, Meishan

    2015-08-01

    We report a newly discovered anomalous incident-angle of an elastically refracted P-wave, arising from a P-wave impinging on an interface between two VTI media with strong anisotropy. This anomalous incident-angle is found to be located in the post-critical incident-angle region corresponding to a refracted P-wave. Invoking Snell’s law for a refracted P-wave provides two distinctive solutions before and after the anomalous incident-angle. For an inhomogeneously refracted and elliptically polarized P-wave at the anomalous incident-angle, its rotational direction experiences an acute variation, from left-hand elliptical to right-hand elliptical polarization. The new findings provide us an enhanced understanding of acoustical-wave scattering and lead potentially to widespread and novel applications.

  18. Anomalous Evidence, Confidence Change, and Theory Change.

    PubMed

    Hemmerich, Joshua A; Van Voorhis, Kellie; Wiley, Jennifer

    2016-08-01

    A novel experimental paradigm that measured theory change and confidence in participants' theories was used in three experiments to test the effects of anomalous evidence. Experiment 1 varied the amount of anomalous evidence to see if "dose size" made incremental changes in confidence toward theory change. Experiment 2 varied whether anomalous evidence was convergent (of multiple types) or replicating (similar finding repeated). Experiment 3 varied whether participants were provided with an alternative theory that explained the anomalous evidence. All experiments showed that participants' confidence changes were commensurate with the amount of anomalous evidence presented, and that larger decreases in confidence predicted theory changes. Convergent evidence and the presentation of an alternative theory led to larger confidence change. Convergent evidence also caused more theory changes. Even when people do not change theories, factors pertinent to the evidence and alternative theories decrease their confidence in their current theory and move them incrementally closer to theory change. Copyright © 2015 Cognitive Science Society, Inc.

  19. Anomalous evolution of Ar metastable density with electron density in high density Ar discharge

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Park, Min; Chang, Hong-Young; You, Shin-Jae

    2011-10-15

    Recently, an anomalous evolution of argon metastable density with plasma discharge power (electron density) was reported [A. M. Daltrini, S. A. Moshkalev, T. J. Morgan, R. B. Piejak, and W. G. Graham, Appl. Phys. Lett. 92, 061504 (2008)]. Although the importance of the metastable atom and its density has been reported in a lot of literature, however, a basic physics behind the anomalous evolution of metastable density has not been clearly understood yet. In this study, we investigated a simple global model to elucidate the underlying physics of the anomalous evolution of argon metastable density with the electron density. Onmore » the basis of the proposed simple model, we reproduced the anomalous evolution of the metastable density and disclosed the detailed physics for the anomalous result. Drastic changes of dominant mechanisms for the population and depopulation processes of Ar metastable atoms with electron density, which take place even in relatively low electron density regime, is the clue to understand the result.« less

  20. Approaching quantum anomalous Hall effect in proximity-coupled YIG/graphene/h-BN sandwich structure

    NASA Astrophysics Data System (ADS)

    Tang, Chi; Cheng, Bin; Aldosary, Mohammed; Wang, Zhiyong; Jiang, Zilong; Watanabe, K.; Taniguchi, T.; Bockrath, Marc; Shi, Jing

    2018-02-01

    Quantum anomalous Hall state is expected to emerge in Dirac electron systems such as graphene under both sufficiently strong exchange and spin-orbit interactions. In pristine graphene, neither interaction exists; however, both interactions can be acquired by coupling graphene to a magnetic insulator as revealed by the anomalous Hall effect. Here, we show enhanced magnetic proximity coupling by sandwiching graphene between a ferrimagnetic insulator yttrium iron garnet (YIG) and hexagonal-boron nitride (h-BN) which also serves as a top gate dielectric. By sweeping the top-gate voltage, we observe Fermi level-dependent anomalous Hall conductance. As the Dirac point is approached from both electron and hole sides, the anomalous Hall conductance reaches ¼ of the quantum anomalous Hall conductance 2e2/h. The exchange coupling strength is determined to be as high as 27 meV from the transition temperature of the induced magnetic phase. YIG/graphene/h-BN is an excellent heterostructure for demonstrating proximity-induced interactions in two-dimensional electron systems.

  1. Systematic Serendipity: A Method to Discover the Anomalous

    NASA Astrophysics Data System (ADS)

    Giles, Daniel; Walkowicz, Lucianne

    2018-01-01

    One of the challenges in the era of big data astronomical surveys is identifying anomalous data, data that exhibits as-of-yet unobserved behavior. These data may result from systematic errors, extreme (or rare) forms of known phenomena, or, most interestingly, truly novel phenomena that has historically required a trained eye and often fortuitous circumstance to identify. We describe a method that uses machine clustering techniques to discover anomalous data in Kepler lightcurves, as a step towards systematizing the detection of novel phenomena in the era of LSST. As a proof of concept, we apply our anomaly detection method to Kepler data including Boyajian's Star (KIC 8462852). We examine quarters 4, 8, 11, and 16 of the Kepler data which contain Boyajian’s Star acting normally (quarters 4 and 11) and anomalously (quarters 8 and 16). We demonstrate that our method is capable of identifying Boyajian’s Star’s anomalous behavior in quarters of interest, and we further identify other anomalous light curves that exhibit a range of interesting variability.

  2. Anomalous neuronal responses to fluctuated inputs

    NASA Astrophysics Data System (ADS)

    Hosaka, Ryosuke; Sakai, Yutaka

    2015-10-01

    The irregular firing of a cortical neuron is thought to result from a highly fluctuating drive that is generated by the balance of excitatory and inhibitory synaptic inputs. A previous study reported anomalous responses of the Hodgkin-Huxley neuron to the fluctuated inputs where an irregularity of spike trains is inversely proportional to an input irregularity. In the current study, we investigated the origin of these anomalous responses with the Hindmarsh-Rose neuron model, map-based models, and a simple mixture of interspike interval distributions. First, we specified the parameter regions for the bifurcations in the Hindmarsh-Rose model, and we confirmed that the model reproduced the anomalous responses in the dynamics of the saddle-node and subcritical Hopf bifurcations. For both bifurcations, the Hindmarsh-Rose model shows bistability in the resting state and the repetitive firing state, which indicated that the bistability was the origin of the anomalous input-output relationship. Similarly, the map-based model that contained bistability reproduced the anomalous responses, while the model without bistability did not. These results were supported by additional findings that the anomalous responses were reproduced by mimicking the bistable firing with a mixture of two different interspike interval distributions. Decorrelation of spike trains is important for neural information processing. For such spike train decorrelation, irregular firing is key. Our results indicated that irregular firing can emerge from fluctuating drives, even weak ones, under conditions involving bistability. The anomalous responses, therefore, contribute to efficient processing in the brain.

  3. The SCEC geodetic transient detection validation exercise

    USGS Publications Warehouse

    Lohman, Rowena B.; Murray, Jessica R.

    2013-01-01

    Over the past decade the number and size of continuously operating Global Positioning System (GPS) networks has grown substantially worldwide. A steadily increasing volume of freely available GPS measurements, combined with the application of new approaches for mining these data for signals of interest, has led to the identification of a large and diverse collection of time‐varying Earth processes. One phenomenon that has been observed is transient fault slip (also termed slow slip events or silent earthquakes) occurring over time spans of days to years (e.g., Linde et al., 1996; Hirose et al., 1999; Dragert et al., 2001; Miller et al., 2002; Kostoglodov et al., 2003; Douglas et al., 2005; Shelly et al., 2006; Ide et al., 2007; Lohman and McGuire, 2007; Schwartz and Rokosky, 2007; Szeliga et al., 2008). Such events have been widely observed in subduction zones but are also found in other tectonic settings (Linde et al., 1996; Cervelli et al., 2002; Murray and Segall, 2005; Lohman and McGuire, 2007; Montgomery‐Brown et al., 2009; Shelly, 2010; and references therein). Although retrospective study of slow‐slip events using geodetic observations is driving the formulation of new models for fault‐zone behavior and constitutive laws (e.g., Lapusta et al., 2000; Liu and Rice, 2007; Lapusta and Liu, 2009; Segall and Bradley, 2012a), much of the research on near‐real‐time detection and characterization of anomalous behaviors along fault zones has focused solely on the use of seismic tremor (e.g., Rogers and Dragert, 2003; Shelly et al., 2006; Ito et al., 2007).

  4. Magnetars: the physics behind observations. A review.

    PubMed

    Turolla, R; Zane, S; Watts, A L

    2015-11-01

    Magnetars are the strongest magnets in the present universe and the combination of extreme magnetic field, gravity and density makes them unique laboratories to probe current physical theories (from quantum electrodynamics to general relativity) in the strong field limit. Magnetars are observed as peculiar, burst-active x-ray pulsars, the anomalous x-ray pulsars (AXPs) and the soft gamma repeaters (SGRs); the latter emitted also three 'giant flares', extremely powerful events during which luminosities can reach up to 10(47) erg s(-1) for about one second. The last five years have witnessed an explosion in magnetar research which has led, among other things, to the discovery of transient, or 'outbursting', and 'low-field' magnetars. Substantial progress has been made also on the theoretical side. Quite detailed models for explaining the magnetars' persistent x-ray emission, the properties of the bursts, the flux evolution in transient sources have been developed and confronted with observations. New insight on neutron star asteroseismology has been gained through improved models of magnetar oscillations. The long-debated issue of magnetic field decay in neutron stars has been addressed, and its importance recognized in relation to the evolution of magnetars and to the links among magnetars and other families of isolated neutron stars. The aim of this paper is to present a comprehensive overview in which the observational results are discussed in the light of the most up-to-date theoretical models and their implications. This addresses not only the particular case of magnetar sources, but the more fundamental issue of how physics in strong magnetic fields can be constrained by the observations of these unique sources.

  5. A sodium channel knockin mutant (NaV1.4-R669H) mouse model of hypokalemic periodic paralysis

    PubMed Central

    Wu, Fenfen; Mi, Wentao; Burns, Dennis K.; Fu, Yu; Gray, Hillery F.; Struyk, Arie F.; Cannon, Stephen C.

    2011-01-01

    Hypokalemic periodic paralysis (HypoPP) is an ion channelopathy of skeletal muscle characterized by attacks of muscle weakness associated with low serum K+. HypoPP results from a transient failure of muscle fiber excitability. Mutations in the genes encoding a calcium channel (CaV1.1) and a sodium channel (NaV1.4) have been identified in HypoPP families. Mutations of NaV1.4 give rise to a heterogeneous group of muscle disorders, with gain-of-function defects causing myotonia or hyperkalemic periodic paralysis. To address the question of specificity for the allele encoding the NaV1.4-R669H variant as a cause of HypoPP and to produce a model system in which to characterize functional defects of the mutant channel and susceptibility to paralysis, we generated knockin mice carrying the ortholog of the gene encoding the NaV1.4-R669H variant (referred to herein as R669H mice). Homozygous R669H mice had a robust HypoPP phenotype, with transient loss of muscle excitability and weakness in low-K+ challenge, insensitivity to high-K+ challenge, dominant inheritance, and absence of myotonia. Recovery was sensitive to the Na+/K+-ATPase pump inhibitor ouabain. Affected fibers had an anomalous inward current at hyperpolarized potentials, consistent with the proposal that a leaky gating pore in R669H channels triggers attacks, whereas a reduction in the amplitude of action potentials implies additional loss-of-function changes for the mutant NaV1.4 channels. PMID:21881211

  6. New results on the resistivity structure of Merapi Volcano(Indonesia), derived from 3D restricted inversion of long-offsettransient electromagnetic data

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Commer, Michael; Helwig, Stefan, L.; Hordt, Andreas

    2006-06-14

    Three long-offset transient electromagnetic (LOTEM) surveyswerecarried out at the active volcano Merapi in Central Java (Indonesia)during the years 1998, 2000, and 2001. The measurements focused on thegeneral resistivity structure of the volcanic edifice at depths of 0.5-2km and the further investigation of a southside anomaly. The measurementswere insufficient for a full 3D inversion scheme, which could enable theimaging of finely discretized resistivity distributions. Therefore, astable, damped least-squares joint-inversion approach is used to optimize3D models with a limited number of parameters. The mode ls feature therealistic simulation of topography, a layered background structure, andadditional coarse 3D blocks representing conductivity anomalies.Twenty-eight LOTEMmore » transients, comprising both horizontal and verticalcomponents of the magnetic induction time derivative, were analyzed. Inview of the few unknowns, we were able to achieve reasonable data fits.The inversion results indicate an upwelling conductor below the summit,suggesting hydrothermal activity in the central volcanic complex. Ashallow conductor due to a magma-filled chamber, at depths down to 1 kmbelow the summit, suggested by earlier seismic studies, is not indicatedby the inversion results. In conjunction with an anomalous-density model,derived from arecent gravity study, our inversion results provideinformation about the southern geological structure resulting from amajor sector collapse during the Middle Merapi period. The density modelallows to assess a porosity range andthus an estimated vertical salinityprofile to explain the high conductivities on a larger scale, extendingbeyond the foothills of Merapi.« less

  7. Automated Propulsion Data Screening demonstration system

    NASA Technical Reports Server (NTRS)

    Hoyt, W. Andes; Choate, Timothy D.; Whitehead, Bruce A.

    1995-01-01

    A fully-instrumented firing of a propulsion system typically generates a very large quantity of data. In the case of the Space Shuttle Main Engine (SSME), data analysis from ground tests and flights is currently a labor-intensive process. Human experts spend a great deal of time examining the large volume of sensor data generated by each engine firing. These experts look for any anomalies in the data which might indicate engine conditions warranting further investigation. The contract effort was to develop a 'first-cut' screening system for application to SSME engine firings that would identify the relatively small volume of data which is unusual or anomalous in some way. With such a system, limited and expensive human resources could focus on this small volume of unusual data for thorough analysis. The overall project objective was to develop a fully operational Automated Propulsion Data Screening (APDS) system with the capability of detecting significant trends and anomalies in transient and steady-state data. However, the effort limited screening of transient data to ground test data for throttle-down cases typical of the 3-g acceleration, and for engine throttling required to reach the maximum dynamic pressure limits imposed on the Space Shuttle. This APDS is based on neural networks designed to detect anomalies in propulsion system data that are not part of the data used for neural network training. The delivered system allows engineers to build their own screening sets for application to completed or planned firings of the SSME. ERC developers also built some generic screening sets that NASA engineers could apply immediately to their data analysis efforts.

  8. Search for anomalous top-quark couplings with the D0 detector.

    PubMed

    Abazov, V M; Abbott, B; Abolins, M; Acharya, B S; Adams, M; Adams, T; Aguilo, E; Ahsan, M; Alexeev, G D; Alkhazov, G; Alton, A; Alverson, G; Alves, G A; Anastasoaie, M; Ancu, L S; Andeen, T; Andrieu, B; Anzelc, M S; Aoki, M; Arnoud, Y; Arov, M; Arthaud, M; Askew, A; Asman, B; Assis Jesus, A C S; Atramentov, O; Avila, C; Backusmayes, J; Badaud, F; Bagby, L; Baldin, B; Bandurin, D V; Banerjee, P; Banerjee, S; Barberis, E; Barfuss, A-F; Bargassa, P; Baringer, P; Barreto, J; Bartlett, J F; Bassler, U; Bauer, D; Beale, S; Bean, A; Begalli, M; Begel, M; Belanger-Champagne, C; Bellantoni, L; Bellavance, A; Benitez, J A; Beri, S B; Bernardi, G; Bernhard, R; Bertram, I; Besançon, M; Beuselinck, R; Bezzubov, V A; Bhat, P C; Bhatnagar, V; Blazey, G; Blekman, F; Blessing, S; Bloom, K; Boehnlein, A; Boline, D; Bolton, T A; Boos, E E; Borissov, G; Bose, T; Brandt, A; Brock, R; Brooijmans, G; Bross, A; Brown, D; Bu, X B; Buchanan, N J; Buchholz, D; Buehler, M; Buescher, V; Bunichev, V; Burdin, S; Burnett, T H; Buszello, C P; Calfayan, P; Calpas, B; Calvet, S; Cammin, J; Carrasco-Lizarraga, M A; Carrera, E; Carvalho, W; Casey, B C K; Castilla-Valdez, H; Chakrabarti, S; Chakraborty, D; Chan, K M; Chandra, A; Cheu, E; Cho, D K; Choi, S; Choudhary, B; Christofek, L; Christoudias, T; Cihangir, S; Claes, D; Clutter, J; Cooke, M; Cooper, W E; Corcoran, M; Couderc, F; Cousinou, M-C; Crépé-Renaudin, S; Cuplov, V; Cutts, D; Cwiok, M; da Motta, H; Das, A; Davies, G; De, K; de Jong, S J; De La Cruz-Burelo, E; De Oliveira Martins, C; DeVaughan, K; Déliot, F; Demarteau, M; Demina, R; Denisov, D; Denisov, S P; Desai, S; Diehl, H T; Diesburg, M; Dominguez, A; Dorland, T; Dubey, A; Dudko, L V; Duflot, L; Dugad, S R; Duggan, D; Duperrin, A; Dutt, S; Dyer, J; Dyshkant, A; Eads, M; Edmunds, D; Ellison, J; Elvira, V D; Enari, Y; Eno, S; Ermolov, P; Escalier, M; Evans, H; Evdokimov, A; Evdokimov, V N; Ferapontov, A V; Ferbel, T; Fiedler, F; Filthaut, F; Fisher, W; Fisk, H E; Fortner, M; Fox, H; Fu, S; Fuess, S; Gadfort, T; Galea, C F; Garcia, C; Garcia-Bellido, A; Gavrilov, V; Gay, P; Geist, W; Geng, W; Gerber, C E; Gershtein, Y; Gillberg, D; Ginther, G; Gómez, B; Goussiou, A; Grannis, P D; Greenlee, H; Greenwood, Z D; Gregores, E M; Grenier, G; Gris, Ph; Grivaz, J-F; Grohsjean, A; Grünendahl, S; Grünewald, M W; Guo, F; Guo, J; Gutierrez, G; Gutierrez, P; Haas, A; Hadley, N J; Haefner, P; Hagopian, S; Haley, J; Hall, I; Hall, R E; Han, L; Harder, K; Harel, A; Hauptman, J M; Hays, J; Hebbeker, T; Hedin, D; Hegeman, J G; Heinson, A P; Heintz, U; Hensel, C; Herner, K; Hesketh, G; Hildreth, M D; Hirosky, R; Hoang, T; Hobbs, J D; Hoeneisen, B; Hohlfeld, M; Hossain, S; Houben, P; Hu, Y; Hubacek, Z; Huske, N; Hynek, V; Iashvili, I; Illingworth, R; Ito, A S; Jabeen, S; Jaffré, M; Jain, S; Jakobs, K; Jarvis, C; Jesik, R; Johns, K; Johnson, C; Johnson, M; Johnston, D; Jonckheere, A; Jonsson, P; Juste, A; Kajfasz, E; Karmanov, D; Kasper, P A; Katsanos, I; Kaushik, V; Kehoe, R; Kermiche, S; Khalatyan, N; Khanov, A; Kharchilava, A; Kharzheev, Y N; Khatidze, D; Kim, T J; Kirby, M H; Kirsch, M; Klima, B; Kohli, J M; Konrath, J-P; Kozelov, A V; Kraus, J; Kuhl, T; Kumar, A; Kupco, A; Kurca, T; Kuzmin, V A; Kvita, J; Lacroix, F; Lam, D; Lammers, S; Landsberg, G; Lebrun, P; Lee, W M; Leflat, A; Lellouch, J; Li, J; Li, L; Li, Q Z; Lietti, S M; Lim, J K; Lima, J G R; Lincoln, D; Linnemann, J; Lipaev, V V; Lipton, R; Liu, Y; Liu, Z; Lobodenko, A; Lokajicek, M; Love, P; Lubatti, H J; Luna-Garcia, R; Lyon, A L; Maciel, A K A; Mackin, D; Madaras, R J; Mättig, P; Magerkurth, A; Mal, P K; Malbouisson, H B; Malik, S; Malyshev, V L; Maravin, Y; Martin, B; McCarthy, R; Meijer, M M; Melnitchouk, A; Mendoza, L; Mercadante, P G; Merkin, M; Merritt, K W; Meyer, A; Meyer, J; Mitrevski, J; Mommsen, R K; Mondal, N K; Moore, R W; Moulik, T; Muanza, G S; Mulhearn, M; Mundal, O; Mundim, L; Nagy, E; Naimuddin, M; Narain, M; Neal, H A; Negret, J P; Neustroev, P; Nilsen, H; Nogima, H; Novaes, S F; Nunnemann, T; O'Neil, D C; Obrant, G; Ochando, C; Onoprienko, D; Oshima, N; Osman, N; Osta, J; Otec, R; Otero y Garzón, G J; Owen, M; Padilla, M; Padley, P; Pangilinan, M; Parashar, N; Park, S-J; Park, S K; Parsons, J; Partridge, R; Parua, N; Patwa, A; Pawloski, G; Penning, B; Perfilov, M; Peters, K; Peters, Y; Pétroff, P; Petteni, M; Piegaia, R; Piper, J; Pleier, M-A; Podesta-Lerma, P L M; Podstavkov, V M; Pogorelov, Y; Pol, M-E; Polozov, P; Pope, B G; Popov, A V; Potter, C; da Silva, W L Prado; Prosper, H B; Protopopescu, S; Qian, J; Quadt, A; Quinn, B; Rakitine, A; Rangel, M S; Ranjan, K; Ratoff, P N; Renkel, P; Rich, P; Rijssenbeek, M; Ripp-Baudot, I; Rizatdinova, F; Robinson, S; Rodrigues, R F; Rominsky, M; Royon, C; Rubinov, P; Ruchti, R; Safronov, G; Sajot, G; Sánchez-Hernández, A; Sanders, M P; Sanghi, B; Savage, G; Sawyer, L; Scanlon, T; Schaile, D; Schamberger, R D; Scheglov, Y; Schellman, H; Schliephake, T; Schlobohm, S; Schwanenberger, C; Schwienhorst, R; Sekaric, J; Severini, H; Shabalina, E; Shamim, M; Shary, V; Shchukin, A A; Shivpuri, R K; Siccardi, V; Simak, V; Sirotenko, V; Skubic, P; Slattery, P; Smirnov, D; Snow, G R; Snow, J; Snyder, S; Söldner-Rembold, S; Sonnenschein, L; Sopczak, A; Sosebee, M; Soustruznik, K; Spurlock, B; Stark, J; Stolin, V; Stoyanova, D A; Strandberg, J; Strandberg, S; Strang, M A; Strauss, E; Strauss, M; Ströhmer, R; Strom, D; Stutte, L; Sumowidagdo, S; Svoisky, P; Sznajder, A; Tanasijczuk, A; Taylor, W; Tiller, B; Tissandier, F; Titov, M; Tokmenin, V V; Torchiani, I; Tsybychev, D; Tuchming, B; Tully, C; Tuts, P M; Unalan, R; Uvarov, L; Uvarov, S; Uzunyan, S; Vachon, B; van den Berg, P J; Van Kooten, R; van Leeuwen, W M; Varelas, N; Varnes, E W; Vasilyev, I A; Verdier, P; Vertogradov, L S; Verzocchi, M; Vilanova, D; Villeneuve-Seguier, F; Vint, P; Vokac, P; Voutilainen, M; Wagner, R; Wahl, H D; Wang, M H L S; Warchol, J; Watts, G; Wayne, M; Weber, G; Weber, M; Welty-Rieger, L; Wenger, A; Wermes, N; Wetstein, M; White, A; Wicke, D; Williams, M R J; Wilson, G W; Wimpenny, S J; Wobisch, M; Wood, D R; Wyatt, T R; Xie, Y; Xu, C; Yacoob, S; Yamada, R; Yang, W-C; Yasuda, T; Yatsunenko, Y A; Ye, Z; Yin, H; Yip, K; Yoo, H D; Youn, S W; Yu, J; Zeitnitz, C; Zelitch, S; Zhao, T; Zhou, B; Zhu, J; Zielinski, M; Zieminska, D; Zivkovic, L; Zutshi, V; Zverev, E G

    2009-03-06

    Anomalous Wtb couplings modify the angular correlations of the top-quark decay products and change the single top-quark production cross section. We present limits on anomalous top-quark couplings by combining information from W boson helicity measurements in top-quark decays and anomalous coupling searches in the single top-quark final state. We set limits on right-handed vector couplings as well as left-handed and right-handed tensor couplings based on about 1 fb(-1) of data collected by the D0 experiment.

  9. Method for non-referential defect characterization using fractal encoding and active contours

    DOEpatents

    Gleason, Shaun S [Knoxville, TN; Sari-Sarraf, Hamed [Lubbock, TX

    2007-05-15

    A method for identification of anomalous structures, such as defects, includes the steps of providing a digital image and applying fractal encoding to identify a location of at least one anomalous portion of the image. The method does not require a reference image to identify the location of the anomalous portion. The method can further include the step of initializing an active contour based on the location information obtained from the fractal encoding step and deforming an active contour to enhance the boundary delineation of the anomalous portion.

  10. Nonlinear anomalous diffusion equation and fractal dimension: exact generalized Gaussian solution.

    PubMed

    Pedron, I T; Mendes, R S; Malacarne, L C; Lenzi, E K

    2002-04-01

    In this work we incorporate, in a unified way, two anomalous behaviors, the power law and stretched exponential ones, by considering the radial dependence of the N-dimensional nonlinear diffusion equation partial differential rho/ partial differential t=nabla.(Knablarho(nu))-nabla.(muFrho)-alpharho, where K=Dr(-theta), nu, theta, mu, and D are real parameters, F is the external force, and alpha is a time-dependent source. This equation unifies the O'Shaughnessy-Procaccia anomalous diffusion equation on fractals (nu=1) and the spherical anomalous diffusion for porous media (theta=0). An exact spherical symmetric solution of this nonlinear Fokker-Planck equation is obtained, leading to a large class of anomalous behaviors. Stationary solutions for this Fokker-Planck-like equation are also discussed by introducing an effective potential.

  11. Apparatus for responding to an anomalous change in downhole pressure

    DOEpatents

    Hall, David R.; Fox, Joe; Wilde, Tyson; Barlow, Jonathan S.

    2010-04-13

    A method of responding to an anomalous change in downhole pressure in a bore hole comprises detecting the anomalous change in downhole pressure, sending a signal along the segmented electromagnetic transmission path, receiving the signal, and performing a automated response. The anomalous change in downhole pressure is detected at a first location along a segmented electromagnetic transmission path, and the segmented electromagnetic transmission path is integrated into the tool string. The signal is received by at least one receiver in communication with the segmented electromagnetic transmission path. The automated response is performed along the tool string. Disclosed is an apparatus for responding to an anomalous change in downhole pressure in a downhole tool string, comprising a segmented electromagnetic transmission path connecting one or more receivers and at least one pressure sensor.

  12. Anomalous effects of dense matter under rotation

    NASA Astrophysics Data System (ADS)

    Huang, Xu-Guang; Nishimura, Kentaro; Yamamoto, Naoki

    2018-02-01

    We study the anomaly induced effects of dense baryonic matter under rotation. We derive the anomalous terms that account for the chiral vortical effect in the low-energy effective theory for light Nambu-Goldstone modes. The anomalous terms lead to new physical consequences, such as the anomalous Hall energy current and spontaneous generation of angular momentum in a magnetic field (or spontaneous magnetization by rotation). In particular, we show that, due to the presence of such anomalous terms, the ground state of the quantum chromodynamics (QCD) under sufficiently fast rotation becomes the "chiral soliton lattice" of neutral pions that has lower energy than the QCD vacuum and nuclear matter. We briefly discuss the possible realization of the chiral soliton lattice induced by a fast rotation in noncentral heavy ion collisions.

  13. Quasi-one-dimensional quantum anomalous Hall systems as new platforms for scalable topological quantum computation

    NASA Astrophysics Data System (ADS)

    Chen, Chui-Zhen; Xie, Ying-Ming; Liu, Jie; Lee, Patrick A.; Law, K. T.

    2018-03-01

    Quantum anomalous Hall insulator/superconductor heterostructures emerged as a competitive platform to realize topological superconductors with chiral Majorana edge states as shown in recent experiments [He et al. Science 357, 294 (2017), 10.1126/science.aag2792]. However, chiral Majorana modes, being extended, cannot be used for topological quantum computation. In this work, we show that quasi-one-dimensional quantum anomalous Hall structures exhibit a large topological regime (much larger than the two-dimensional case) which supports localized Majorana zero energy modes. The non-Abelian properties of a cross-shaped quantum anomalous Hall junction is shown explicitly by time-dependent calculations. We believe that the proposed quasi-one-dimensional quantum anomalous Hall structures can be easily fabricated for scalable topological quantum computation.

  14. Anomalous Experiences, Trauma, and Symbolization Processes at the Frontiers between Psychoanalysis and Cognitive Neurosciences

    PubMed Central

    Rabeyron, Thomas; Loose, Tianna

    2015-01-01

    Anomalous or exceptional experiences are uncommon experiences which are usually interpreted as being paranormal by those who report them. These experiences have long remained difficult to explain, but current progress in cognitive neuroscience and psychoanalysis sheds light on the contexts in which they emerge, as well as on their underlying processes. Following a brief description of the different types of anomalous experiences, we underline how they can be better understood at the frontiers between psychoanalysis and cognitive neurosciences. In this regard, three main lines of research are discussed and illustrated, alongside clinical cases which come from a clinical service specializing in anomalous experiences. First, we study the links between anomalous experiences and hallucinatory processes, by showing that anomalous experiences frequently occur as a specific reaction to negative life events, in which case they mainly take the form of non-pathological hallucinations. Next, we propose to analyze these experiences from the perspective of their traumatic aspects and the altered states of consciousness they often imply. Finally, these experiences are considered to be the consequence of a hypersensitivity that can be linked to an increase in psychic permeability. In conclusion, these different processes lead us to consider anomalous experiences as primary forms of symbolization and transformation of the subjective experience, especially during, or after traumatic situations. PMID:26732646

  15. Structural controls on anomalous transport in fractured porous rock

    NASA Astrophysics Data System (ADS)

    Edery, Yaniv; Geiger, Sebastian; Berkowitz, Brian

    2016-07-01

    Anomalous transport is ubiquitous in a wide range of disordered systems, notably in fractured porous formations. We quantitatively identify the structural controls on anomalous tracer transport in a model of a real fractured geological formation that was mapped in an outcrop. The transport, determined by a continuum scale mathematical model, is characterized by breakthrough curves (BTCs) that document anomalous (or "non-Fickian") transport, which is accounted for by a power law distribution of local transition times ψ>(t>) within the framework of a continuous time random walk (CTRW). We show that the determination of ψ>(t>) is related to fractures aligned approximately with the macroscopic direction of flow. We establish the dominant role of fracture alignment and assess the statistics of these fractures by determining a concentration-visitation weighted residence time histogram. We then convert the histogram to a probability density function (pdf) that coincides with the CTRW ψ>(t>) and hence anomalous transport. We show that the permeability of the geological formation hosting the fracture network has a limited effect on the anomalous nature of the transport; rather, it is the fractures transverse to the flow direction that play the major role in forming the long BTC tail associated with anomalous transport. This is a remarkable result, given the complexity of the flow field statistics as captured by concentration transitions.

  16. Self-affinity and self-organized criticality applied to the relationship between the economic arrangements and the dengue fever spread in Bahia

    NASA Astrophysics Data System (ADS)

    Filho, A. S. Nascimento; Araújo, M. L. V.; Miranda, J. G. V.; Murari, T. B.; Saba, H.; Moret, M. A.

    2018-07-01

    In this paper, we evaluate whether the diffusion of the dengue fever can be explained by differences among regional economies. We evaluate the dengue fever self-affinity behavior and self-organized critical behavior within the fifteen economic regions of State of Bahia, Brazil, between 2000 and 2009. The results showed two distinct behaviors for long-range correlation scaling: persistent for a month and subdiffusive for one year, according to DFA method. Furthermore, the dengue fever distribution presented power law behaviors for these data sets, according to SOC analysis. In this study, we concluded that this disease was not influenced by economic aspects or regional arrangement, and also suggest that the disease's vector (Aedes aegypti mosquito) has adapted to all the economic regions.

  17. Correlated continuous time random walk and option pricing

    NASA Astrophysics Data System (ADS)

    Lv, Longjin; Xiao, Jianbin; Fan, Liangzhong; Ren, Fuyao

    2016-04-01

    In this paper, we study a correlated continuous time random walk (CCTRW) with averaged waiting time, whose probability density function (PDF) is proved to follow stretched Gaussian distribution. Then, we apply this process into option pricing problem. Supposing the price of the underlying is driven by this CCTRW, we find this model captures the subdiffusive characteristic of financial markets. By using the mean self-financing hedging strategy, we obtain the closed-form pricing formulas for a European option with and without transaction costs, respectively. At last, comparing the obtained model with the classical Black-Scholes model, we find the price obtained in this paper is higher than that obtained from the Black-Scholes model. A empirical analysis is also introduced to confirm the obtained results can fit the real data well.

  18. Collective motion of macroscopic spheres floating on capillary ripples: Dynamic heterogeneity and dynamic criticality

    NASA Astrophysics Data System (ADS)

    Sanlı, Ceyda; Saitoh, Kuniyasu; Luding, Stefan; van der Meer, Devaraj

    2014-09-01

    When a densely packed monolayer of macroscopic spheres floats on chaotic capillary Faraday waves, a coexistence of large scale convective motion and caging dynamics typical for glassy systems is observed. We subtract the convective mean flow using a coarse graining (homogenization) method and reveal subdiffusion for the caging time scales followed by a diffusive regime at later times. We apply the methods developed to study dynamic heterogeneity and show that the typical time and length scales of the fluctuations due to rearrangements of observed particle groups significantly increase when the system approaches its largest experimentally accessible packing concentration. To connect the system to the dynamic criticality literature, we fit power laws to our results. The resultant critical exponents are consistent with those found in densely packed suspensions of colloids.

  19. Compact structure and non-Gaussian dynamics of ring polymer melts.

    PubMed

    Brás, Ana R; Goossen, Sebastian; Krutyeva, Margarita; Radulescu, Aurel; Farago, Bela; Allgaier, Jürgen; Pyckhout-Hintzen, Wim; Wischnewski, Andreas; Richter, Dieter

    2014-05-28

    We present a neutron scattering analysis of the structure and dynamics of PEO polymer rings with a molecular weight 2.5 times higher than the entanglement mass. The melt structure was found to be more compact than a Gaussian model would suggest. With increasing time the center of mass (c.o.m.) diffusion undergoes a transition from sub-diffusive to diffusive behavior. The transition time agrees well with the decorrelation time predicted by a mode coupling approach. As a novel feature well pronounced non-Gaussian behavior of the c.o.m. diffusion was found that shows surprising analogies to the cage effect known from glassy systems. Finally, the longest wavelength Rouse modes are suppressed possibly as a consequence of an onset of lattice animal features as hypothesized in theoretical approaches.

  20. Self-Trapping Self-Repelling Random Walks

    NASA Astrophysics Data System (ADS)

    Grassberger, Peter

    2017-10-01

    Although the title seems self-contradictory, it does not contain a misprint. The model we study is a seemingly minor modification of the "true self-avoiding walk" model of Amit, Parisi, and Peliti in two dimensions. The walks in it are self-repelling up to a characteristic time T* (which depends on various parameters), but spontaneously (i.e., without changing any control parameter) become self-trapping after that. For free walks, T* is astronomically large, but on finite lattices the transition is easily observable. In the self-trapped regime, walks are subdiffusive and intermittent, spending longer and longer times in small areas until they escape and move rapidly to a new area. In spite of this, these walks are extremely efficient in covering finite lattices, as measured by average cover times.

  1. Collective motion of macroscopic spheres floating on capillary ripples: dynamic heterogeneity and dynamic criticality.

    PubMed

    Sanlı, Ceyda; Saitoh, Kuniyasu; Luding, Stefan; van der Meer, Devaraj

    2014-09-01

    When a densely packed monolayer of macroscopic spheres floats on chaotic capillary Faraday waves, a coexistence of large scale convective motion and caging dynamics typical for glassy systems is observed. We subtract the convective mean flow using a coarse graining (homogenization) method and reveal subdiffusion for the caging time scales followed by a diffusive regime at later times. We apply the methods developed to study dynamic heterogeneity and show that the typical time and length scales of the fluctuations due to rearrangements of observed particle groups significantly increase when the system approaches its largest experimentally accessible packing concentration. To connect the system to the dynamic criticality literature, we fit power laws to our results. The resultant critical exponents are consistent with those found in densely packed suspensions of colloids.

  2. Why rainfall response to El Niño over Maritime Continent is weaker and non-uniform in boreal winter than in boreal summer

    NASA Astrophysics Data System (ADS)

    Jiang, Leishan; Li, Tim

    2017-11-01

    Why rainfall response to El Niño is uniform and stronger over the Maritime Continent (MC) during El Niño developing summer and fall but is weaker and non-uniform during El Niño mature winter is investigated through the diagnosis of anomalous large-scale circulation patterns and a local moisture budget analysis. It is found that when anomalous Walker cells across the equatorial Pacific and Indian Ocean are strengthened toward El Niño mature winter, a low-level ascending motion anomaly starts to develop over western MC in northern fall due to topographic lifting (near Sumatra) and anomalous wind convergence (near west Kalimantan). Easterly anomalies, as a part of an anomalous anticyclone in South China Sea (SCS) that is developed during El Niño and a part of the south-easterly from Java Sea associated with anomalous Walker Circulation, bump into the mountain ridge of Sumatra and induce ascending motion anomalies near Sumatra. Meanwhile, the anomalous north-easterly in the southern flank of the anomalous anticyclone over SCS and south-easterly over Java Sea converge into west Kalimantan, leading to ascending motion there. The anomalous ascending motion tend to advect mean moisture upward to moisten lower troposphere in situ. This low-level moistening eventually sets up a convectively unstable stratification and induces a positive precipitation anomaly in the western MC. How the mechanism discussed here is relevant to previous hypotheses and how processes during El Niño might differ during La Niña are discussed.

  3. Analyzing "Real-World" Anomalous Data after Experimentation with a Virtual Laboratory

    ERIC Educational Resources Information Center

    Toth, Eva Erdosne

    2016-01-01

    Developing effective pedagogies to help students examine anomalous data is critical for the education of the next generation of scientists and engineers. By definition anomalous data do not concur with prior knowledge, theories and expectations. Such data are the common outcome of empirical investigation in hands-on laboratories (HOLs). These…

  4. Surgical management of tricuspid atresia and anomalous left brachiocephalic vein.

    PubMed

    Koutlas, T C; Wernovsky, G; Slack, M C; Weinberg, P M; Spray, T L

    1998-06-01

    An anomalous left brachiocephalic vein is an uncommon systemic venous anomaly, which usually has no clinical significance. We describe a case of tricuspid atresia with such an anomalous left brachiocephalic vein. The presence of this unusual venous anomaly had a number of implications in the surgical management of the tricuspid atresia.

  5. Children's Responses to Anomalous Scientific Data: How Is Conceptual Change Impeded?

    ERIC Educational Resources Information Center

    Chinn, Clark A.; Malhotra, Betina A.

    2002-01-01

    Four experiments with 4th, 5th, and 6th graders addressed conceptual change in response to anomalous data about empirical regularities in science. Impedance to conceptual change in response to anomalous data could potentially occur at any of four cognitive processes: observation, interpretation, generalization, or retention. In the four…

  6. Responses to Anomalous Data Obtained from Repeatable Experiments in the Laboratory

    ERIC Educational Resources Information Center

    Lin, Jer-Yann

    2007-01-01

    The purpose of this study was to investigate the possible responses to anomalous data obtained from experiments that are repeatable by carrying out additional or alternative experiments in the laboratory. Based on an analysis of responses from scientists to anomalous data taken from identification experiments on the Vinland Map, it was assumed…

  7. Anomalous fluxes in the plateau regime for a weakly turbulent, magnetically confined plasma

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Balescu, R.

    1990-09-01

    The anomalous particle and heat fluxes, together with the parallel electric current, are determined for a confined plasma in the plateau regime in the presence of weak electrostatic drift-wave turbulence. Proper account is taken of nonstationarity and of the finite ion Larmor radius (FLR). The quasineutrality of the drift-wave fluctuations imposes a consistency condition, by which the evaluation of the anomalous fluxes is closely related to the drift-wave dispersion equation. On the other hand, these fluxes are related to the thermodynamic forces via the poloidal fluxes. For the weak turbulence approximation considered here, a unified formulation of the anomalous transportmore » problem has been obtained, including all aspects of neoclassical theory. The complete set of transport coefficients is calculated and various relations between them are exhibited. It clearly appears, for instance, that the anomalous ion heat flux is a pure FLR effect that vanishes as the Larmor radius goes to zero. The Onsager symmetry is broken for anomalous transport. The Appendix is devoted to a general discussion of the concept of heat flux in turbulent plasmas.« less

  8. Formation of anomalous eutectic in Ni-Sn alloy by laser cladding

    NASA Astrophysics Data System (ADS)

    Wang, Zhitai; Lin, Xin; Cao, Yongqing; Liu, Fencheng; Huang, Weidong

    2018-02-01

    Ni-Sn anomalous eutectic is obtained by single track laser cladding with the scanning velocity from 1 mm/s to 10 mm/s using the Ni-32.5 wt.%Sn eutectic powders. The microstructure of the cladding layer and the grain orientations of anomalous eutectic were investigated. It is found that the microstructure is transformed from primary α-Ni dendrites and the interdendritic (α-Ni + Ni3Sn) eutectic at the bottom of the cladding layer to α-Ni and β-Ni3Sn anomalous eutectic at the top of the cladding layer, whether for single layer or multilayer laser cladding. The EBSD maps and pole figures indicate that the spatially structure of α-Ni phase is discontinuous and the Ni3Sn phase is continuous in anomalous eutectic. The transformation from epitaxial growth columnar at bottom of cladding layer to free nucleation equiaxed at the top occurs, i.e., the columnar to equiaxed transition (CET) at the top of cladding layer during laser cladding processing leads to the generation of anomalous eutectic.

  9. The principle of maximal transcendentality and the four-loop collinear anomalous dimension

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Dixon, Lance J.

    Here, we use the principle of maximal transcendentality and the universal nature of subleading infrared poles to extract the analytic value of the four-loop collinear anomalous dimension in planar N = 4 super-Yang-Mills theory from recent QCD results, obtainingmore » $$\\hat{g}$$$(4)\\atop{0}$$ =$-$300ζ 7$-$256ζ 2ζ 5$-$384ζ 3ζ 4. This value agrees with a previous numerical result to within 0.2%. It also provides the Regge trajectory, threshold soft anomalous dimension and rapidity anomalous dimension through four loops.« less

  10. The principle of maximal transcendentality and the four-loop collinear anomalous dimension

    DOE PAGES

    Dixon, Lance J.

    2018-01-16

    Here, we use the principle of maximal transcendentality and the universal nature of subleading infrared poles to extract the analytic value of the four-loop collinear anomalous dimension in planar N = 4 super-Yang-Mills theory from recent QCD results, obtainingmore » $$\\hat{g}$$$(4)\\atop{0}$$ =$-$300ζ 7$-$256ζ 2ζ 5$-$384ζ 3ζ 4. This value agrees with a previous numerical result to within 0.2%. It also provides the Regge trajectory, threshold soft anomalous dimension and rapidity anomalous dimension through four loops.« less

  11. Anomalous cosmic ray interaction events for investigations in the SSC and Space Station era - 'Long lived she-devil phenomena'

    NASA Technical Reports Server (NTRS)

    Takahashi, Y.

    1985-01-01

    Observational data on anomalous cosmic-ray interaction events are compiled, classified, and briefly characterized. The events are divided into three groups: those confirmed by later observation or experiment, those shown to be the result of observational or analytical error, and those still unexplained. Among the phenomena in the latter group are magnetic-monopole candidates, fractionally charged particles, massive stable particles, anomalons, proton-decay and neutron-oscillation candidates, muon bundles, narrow showers, anomalous photons, fanlike phenomena, quark-gluon-plasma candidates, and anomalous long-range delta rays.

  12. Anomalous transport in the H-mode pedestal of Alcator C-Mod discharges

    NASA Astrophysics Data System (ADS)

    Pankin, A. Y.; Hughes, J. W.; Greenwald, M. J.; Kritz, A. H.; Rafiq, T.

    2017-02-01

    Anomalous transport in the H-mode pedestal region of five Alcator C-Mod discharges, representing a collisionality scan is analyzed. The understanding of anomalous transport in the pedestal region is important for the development of a comprehensive model for the H-mode pedestal slope. In this research, a possible role of the drift resistive inertial ballooning modes (Rafiq et al 2010 Phys. Plasmas 17 082511) in the edge of Alcator C-Mod discharges is analyzed. The stability analysis, carried out using the TRANSP code, indicates that the DRIBM modes are strongly unstable in Alcator C-Mod discharges with large electron collisionality. An improved interpretive analysis of H-mode pedestal experimental data is carried out utilizing the additive flux minimization technique (Pankin et al 2013 Phys. Plasmas 20 102501) together with the guiding-center neoclassical kinetic XGC0 code. The neoclassical and neutral physics are simulated in the XGC0 code and the anomalous fluxes are computed using the additive flux minimization technique. The anomalous fluxes are reconstructed and compared with each other for the collisionality scan Alcator C-Mod discharges. It is found that the electron thermal anomalous diffusivities at the pedestal top increase with the electron collisionality. This dependence can also point to the drift resistive inertial ballooning modes as the modes that drive the anomalous transport in the plasma edge of highly collisional discharges.

  13. True Anomalous Osmosis in Multi-Solute Model Membrane Systems

    PubMed Central

    Grim, Eugene; Sollner, Karl

    1960-01-01

    The transport of liquid across charged porous membranes separating two electrolytic solutions of different composition consists of both a normal and an anomalous osmotic component. Anomalous osmosis does not occur with electroneutral membranes. Thus, with membranes which can be charged and discharged reversibly, normal osmosis can be measured with the membrane in the electroneutral state, and normal together with anomalous osmosis with the membrane in a charged state, the difference between these two effects being the true anomalous osmosis. Data are presented on the osmotic effects across an oxyhemoglobin membrane in the uncharged state at pH 6.75 and in two charged states, positive at pH 4.0 and negative at pH 10.0, in multi-solute systems with 0.2 and 0.4 osmolar solutions of a variety of electrolytes and of glucose against solutions of other solutes of the same, one-half, and twice these osmolarities. In the simpler systems the magnitude of the true anomalous osmosis can be predicted semiquantitatively by reference to appropriate single-solute systems. In isoosmolar systems with two electrolytic solutions the anomalous osmotic flow rates may reach 300 µl./cm.2 hr. and more; systems with electrolytic solutions against solutions of glucose can produce twice this rate. These fluxes are of the same order of magnitude as the liquid transport rates across such living structures as the mucosa of dog gall bladder, ileum, and urinary bladder. PMID:13708691

  14. Anomalous photoconductivity

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Korsunskii, M.I.

    1973-01-01

    Translated from Russian by E. Harnik. This book investigates the nature and properties of anomalous (negative) photoconductivity observed in specially treated (mercury-activated) amorphous selenium films. A phenomenological theory is given, some properties of long-life traps are described, and a new type of centers (s-centers or storage centers) is discussed. Preparation of anomalously photoconductive Se and possible applications are considered. (86 references) (DLC)

  15. Effect of anomalous tbW vertex on decay-lepton distributions in e+ e-® tt(bar) and CP-violating asymmetries

    NASA Astrophysics Data System (ADS)

    Rindani, Saurabh D.

    2000-06-01

    We obtain analytic expressions for the energy and polar-angle double differential distributions of a secondary lepton l+(l-) arising from the decay of t (tbar) in with an anomalous tbW decay vertex. We also obtain analytic expressions for the various differential cross-sections with the lepton energy integrated over. In this case, we find that the angular distributions of the secondary lepton do not depend on the anomalous coupling in the decay, regardless of possible anomalous couplings occurring in the production amplitude for . Our study includes the effect of longitudinal e- and e+ beam polarization. We also study the lepton energy and beam polarization dependence of certain CP-violating lepton angular asymmetries arising from an anomalous tbW decay vertex and compare them with the asymmetries arising due to CP-violation in the production process due to the top electric or weak dipole moment.

  16. SAD phasing with in-house cu Ka radiation using barium as anomalous scatterer.

    PubMed

    Dhanasekaran, V; Velmurugan, D

    2011-12-01

    Phasing of lysozyme crystals using co-crystallized barium ions was performed using single-wavelength anomalous diffraction (SAD) method using Cu Ka radiation with in-house source of data collection. As the ion binding sites vary with respect to the pH of the buffer during crystallization, the highly isomorphic forms of lysozyme crystals grown at acidic and alkaline pH were used for the study. Intrinsic sulphur anomalous signal was also utilized with anomalous signal from lower occupancy ions for phasing. The study showed that to solve the structure by SAD technique, 2.8-fold data redundancy was sufficient when barium was used as an anomalous marker in the in-house copper X-ray radiation source for data collection. Therefore, co-crystallization of proteins with barium containing salt can be a powerful tool for structure determination using lab source.

  17. Simultaneous generation of high-efficiency broadband asymmetric anomalous refraction and reflection waves with few-layer anisotropic metasurface

    PubMed Central

    Li, Zhancheng; Liu, Wenwei; Cheng, Hua; Liu, Jieying; Chen, Shuqi; Tian, Jianguo

    2016-01-01

    Optical metasurfaces consisting of single-layer nanostructures have immensely promising applications in wavefront control because they can be used to arbitrarily manipulate wave phase, and polarization. However, anomalous refraction and reflection waves have not yet been simultaneously and asymmetrically generated, and the limited efficiency and bandwidth of pre-existing single-layer metasurfaces hinder their practical applications. Here, a few-layer anisotropic metasurface is presented for simultaneously generating high-efficiency broadband asymmetric anomalous refraction and reflection waves. Moreover, the normal transmission and reflection waves are low and the anomalous waves are the predominant ones, which is quite beneficial for practical applications such as beam deflectors. Our work provides an effective method of enhancing the performance of anomalous wave generation, and the asymmetric performance of the proposed metasurface shows endless possibilities in wavefront control for nanophotonics device design and optical communication applications. PMID:27762286

  18. Tunneling Anomalous and Spin Hall Effects.

    PubMed

    Matos-Abiague, A; Fabian, J

    2015-07-31

    We predict, theoretically, the existence of the anomalous Hall effect when a tunneling current flows through a tunnel junction in which only one of the electrodes is magnetic. The interfacial spin-orbit coupling present in the barrier region induces a spin-dependent momentum filtering in the directions perpendicular to the tunneling current, resulting in a skew tunneling even in the absence of impurities. This produces an anomalous Hall conductance and spin Hall currents in the nonmagnetic electrode when a bias voltage is applied across the tunneling heterojunction. If the barrier is composed of a noncentrosymmetric material, the anomalous Hall conductance and spin Hall currents become anisotropic with respect to both the magnetization and crystallographic directions, allowing us to separate this interfacial phenomenon from the bulk anomalous and spin Hall contributions. The proposed effect should be useful for proving and quantifying the interfacial spin-orbit fields in metallic and metal-semiconductor systems.

  19. The charmonium dissociation in an ''anomalous wind''

    DOE PAGES

    Sadofyev, Andrey V.; Yin, Yi

    2016-01-11

    We study the charmonium dissociation in a strongly coupled chiral plasma in the presence of magnetic field and axial charge imbalance. This type of plasma carries "anomalous flow" induced by the chiral anomaly and exhibits novel transport phenomena such as chiral magnetic effect. We found that the "anomalous flow" would modify the charmonium color screening length by using the gauge/gravity correspondence. We derive an analytical expression quantifying the "anomalous flow" experienced by a charmonium for a large class of chiral plasma with a gravity dual. We elaborate on the similarity and it qualitative difference between anomalous effects on the charmoniummore » color screening length which are model-dependent and those on the heavy quark drag force which are fixed by the second law of thermodynamics. As a result, we speculate on the possible charmonium dissociation induced by the chiral anomaly in heavy ion collisions.« less

  20. Thermally driven anomalous Hall effect transitions in FeRh

    NASA Astrophysics Data System (ADS)

    Popescu, Adrian; Rodriguez-Lopez, Pablo; Haney, Paul M.; Woods, Lilia M.

    2018-04-01

    Materials exhibiting controllable magnetic phase transitions are currently in demand for many spintronics applications. Here, we investigate from first principles the electronic structure and intrinsic anomalous Hall, spin Hall, and anomalous Nernst response properties of the FeRh metallic alloy which undergoes a thermally driven antiferromagnetic-to-ferromagnetic phase transition. We show that the energy band structures and underlying Berry curvatures have important signatures in the various Hall effects. Specifically, the suppression of the anomalous Hall and Nernst effects in the antiferromagnetic state and a sign change in the spin Hall conductivity across the transition are found. It is suggested that the FeRh can be used as a spin current detector capable of differentiating the spin Hall effect from other anomalous transverse effects. The implications of this material and its thermally driven phases as a spin current detection scheme are also discussed.

  1. [Developmental anatomy of anomalous structure and investigation of medicinal parts Sophora flavescens].

    PubMed

    Wang, Jun; Xie, Xiaomei; Peng, Huasheng

    2012-06-01

    To elucidate the composition structure of "annual rings" and the formation process of anomalous structures in Sophora flavescens, and further discuss the medicinal parts of S. flavescens. Based on investigation on S. flavescens in its producing areas, the morphology of root systems was observed, and the developmental anatomy of roots was researched. Creeping underground rhizomes of S. flavescen existed in some parts of the north place, there were many differences in appearance characters and microscopic features between these roots and rhizomes. Parenchyma cells in secondary xylem regained meristematic ability, became into anomalous cambia, and then developed into anomalous structures. "Annual rings" in transverse section of S. flavescens were not actually growth rings, they were made up of anomalous parenchyma girdle in secondary xylem and normal secondary structure. Roots are the medicinal parts of S. flavescens. This paper suggests that "annual rings" in the decoction pieces of S. flavescens should be called "annular structure".

  2. Modeling anomalous radial transport in kinetic transport codes

    NASA Astrophysics Data System (ADS)

    Bodi, K.; Krasheninnikov, S. I.; Cohen, R. H.; Rognlien, T. D.

    2009-11-01

    Anomalous transport is typically the dominant component of the radial transport in magnetically confined plasmas, where the physical origin of this transport is believed to be plasma turbulence. A model is presented for anomalous transport that can be used in continuum kinetic edge codes like TEMPEST, NEO and the next-generation code being developed by the Edge Simulation Laboratory. The model can also be adapted to particle-based codes. It is demonstrated that the model with a velocity-dependent diffusion and convection terms can match a diagonal gradient-driven transport matrix as found in contemporary fluid codes, but can also include off-diagonal effects. The anomalous transport model is also combined with particle drifts and a particle/energy-conserving Krook collision operator to study possible synergistic effects with neoclassical transport. For the latter study, a velocity-independent anomalous diffusion coefficient is used to mimic the effect of long-wavelength ExB turbulence.

  3. Anomalous Subsidence at Rifted Continental Margins: Distinguishing Mantle Dynamic Topography from Anomalous Oceanic Crustal Thickness

    NASA Astrophysics Data System (ADS)

    Cowie, L.; Kusznir, N. J.

    2012-12-01

    It has been proposed that some continental rifted margins have anomalous subsidence histories and that at breakup they were elevated at shallower bathymetries than the isostatic response of classical rift models (McKenzie 1978) would predict. The existence of anomalous syn or post breakup subsidence of this form would have important implications for our understanding of the geodynamics of continental breakup and rifted continental margin formation, margin subsidence history and the evolution of syn and post breakup depositional systems. We have investigated three rifted continental margins; the Gulf of Aden, Galicia Bank and the Gulf of Lions, to determine whether the oceanic crust in the ocean-continent transition of these margins has present day anomalous subsidence and if so, whether it is caused by mantle dynamic topography or anomalous oceanic crustal thickness. Residual depth anomalies (RDA) corrected for sediment loading, using flexural backstripping and decompaction, have been calculated by comparing observed and age predicted oceanic bathymetries in order to identify anomalous oceanic bathymetry and subsidence at these margins. Age predicted bathymetric anomalies have been calculated using the thermal plate model predictions from Crosby & McKenzie (2009). Non-zero sediment corrected RDAs may result from anomalous oceanic crustal thickness with respect to the global average, or from mantle dynamic uplift. Positive RDAs may result from thicker than average oceanic crust or mantle dynamic uplift; negative RDAs may result from thinner than average oceanic crust or mantle dynamic subsidence. Gravity inversion incorporating a lithosphere thermal gravity anomaly correction and sediment thickness from 2D seismic data has been used to determine Moho depth and oceanic crustal basement thickness. The reference Moho depths used in the gravity inversion have been calibrated against seismic refraction Moho depths. The gravity inversion crustal basement thicknesses together with Airy isostasy have been used to predict a "synthetic" gravity derived RDA. Sediment corrected RDA for oceanic crust in the Gulf of Aden are positive (+750m) indicating anomalous uplift with respect to normal subsidence. Gravity inversion predicts normal thickness oceanic crust and a zero "synthetic" gravity derived RDA in the oceanic domain. The difference between the positive sediment corrected RDA and the zero "synthetic" gravity derived RDA, implies that the anomalous subsidence reported in the Gulf of Aden is the result of mantle dynamic uplift. For the oceanic crust outboard of Galicia Bank both the sediment corrected RDA and the "synthetic" gravity derived RDA are negative (-800m) and of similar magnitude, indicating anomalous subsidence, which is the result of anomalously thin oceanic crust, not mantle dynamic topography. We conclude that there is negligible mantle dynamic topography influencing the Galicia Bank region. In the Gulf of Lions, gravity inversion predicts thinner than average oceanic crust. Both sediment corrected RDA (-1km) and "synthetic" gravity derived RDA (-500m) are negative. The more negative sediment corrected RDA compared with the "synthetic" gravity derived RDA implies that the anomalous subsidence in the Gulf of Lions is the result of mantle dynamic subsidence as well as thinner than average oceanic crust.

  4. Bootstrapping rapidity anomalous dimensions for transverse-momentum resummation

    DOE PAGES

    Li, Ye; Zhu, Hua Xing

    2017-01-11

    Soft function relevant for transverse-momentum resummation for Drell-Yan or Higgs production at hadron colliders are computed through to three loops in the expansion of strong coupling, with the help of bootstrap technique and supersymmetric decomposition. The corresponding rapidity anomalous dimension is extracted. Furthermore, an intriguing relation between anomalous dimensions for transverse-momentum resummation and threshold resummation is found.

  5. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mei, Yang; Ramanathan, Arvind; Glover, Karen

    BECN1 is essential for autophagy, a critical eukaryotic cellular homeostasis pathway. Here we delineate a highly conserved BECN1 domain located between previously characterized BH3 and coiled-coil domains and elucidate its structure and role in autophagy. The 2.0 angstrom sulfur-single-wavelength anomalous dispersion X-ray crystal structure of this domain demonstrates that its N-terminal half is unstructured while its C-terminal half is helical; hence, we name it the flexible helical domain (FHD). Circular dichroism spectroscopy, double electron electron resonance electron paramagnetic resonance, and small-angle X-ray scattering (SAXS) analyses confirm that the FHD is partially disordered, even in the context of adjacent BECN1 domains.more » Molecular dynamic simulations fitted to SAXS data indicate that the FHD transiently samples more helical conformations. FHD helicity increases in 2,2,2-trifluoroethanol, suggesting it may become more helical upon binding. Lastly, cellular studies show that conserved FHD residues are required for starvation-induced autophagy. Thus, the FHD likely undergoes a binding-associated disorder to-helix transition, and conserved residues critical for this interaction are essential for starvation-induced autophagy.« less

  6. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mei, Yang; Ramanathan, Arvind; Glover, Karen

    BECN1 is essential for autophagy, a critical eukaryotic cellular homeostasis pathway. Here in this study, we delineate a highly conserved BECN1 domain located between previously characterized BH3 and coiled-coil domains and elucidate its structure and role in autophagy. The 2.0 Å sulfur-single-wavelength anomalous dispersion X-ray crystal structure of this domain demonstrates that its N-terminal half is unstructured while its C-terminal half is helical; hence, we name it the flexible helical domain (FHD). Circular dichroism spectroscopy, double electron–electron resonance–electron paramagnetic resonance, and small-angle X-ray scattering (SAXS) analyses confirm that the FHD is partially disordered, even in the context of adjacent BECN1more » domains. Molecular dynamic simulations fitted to SAXS data indicate that the FHD transiently samples more helical conformations. FHD helicity increases in 2,2,2-trifluoroethanol, suggesting it may become more helical upon binding. Finally, cellular studies show that conserved FHD residues are required for starvation-induced autophagy. Thus, the FHD likely undergoes a binding-associated disorder-to-helix transition, and conserved residues critical for this interaction are essential for starvation-induced autophagy.« less

  7. Thermophysical Properties of Liquid Te: Density, Electrical Conductivity, and Viscosity

    NASA Technical Reports Server (NTRS)

    Li, C.; Su, C.; Lehoczky, S. L.; Scripa, R. N.; Ban, H.; Lin, B.

    2004-01-01

    The thermophysical properties of liquid Te, namely, density, electrical conductivity, and viscosity, were determined using the pycnometric and transient torque methods from the melting point of Te (723 K) to approximately 1150 K. A maximum was observed in the density of liquid Te as the temperature was increased. The electrical conductivity of liquid Te increased to a constant value of 2.89 x 10(exp 5 OMEGA-1m-1) as the temperature was raised above 1000 K. The viscosity decreased rapidly upon heating the liquid to elevated temperatures. The anomalous behaviors of the measured properties are explained as caused by the structural transitions in the liquid and discussed in terms of Eyring's and Bachiskii's predicted behaviors for homogeneous liquids. The Properties were also measured as a function of time after the liquid was coded from approximately 1173 or 1123 to 823 K. No relaxation phenomena were observed in the properties after the temperature of liquid Te was decreased to 823 K, in contrast to the relaxation behavior observed for some of the Te compounds.

  8. Paleoclassical transport explains electron transport barriers in RTP and TEXTOR

    NASA Astrophysics Data System (ADS)

    Hogeweij, G. M. D.; Callen, J. D.; RTP Team; TEXTOR Team

    2008-06-01

    The recently developed paleoclassical transport model sets the minimum level of electron thermal transport in a tokamak. This transport level has proven to be in good agreement with experimental observations in many cases when fluctuation-induced anomalous transport is small, i.e. in (near-)ohmic plasmas in small to medium size tokamaks, inside internal transport barriers (ITBs) or edge transport barriers (H-mode pedestal). In this paper predictions of the paleoclassical transport model are compared in detail with data from such kinds of discharges: ohmic discharges from the RTP tokamak, EC heated RTP discharges featuring both dynamic and shot-to-shot scans of the ECH power deposition radius and off-axis EC heated discharges from the TEXTOR tokamak. For ohmically heated RTP discharges the Te profiles predicted by the paleoclassical model are in reasonable agreement with the experimental observations, and various parametric dependences are captured satisfactorily. The electron thermal ITBs observed in steady state EC heated RTP discharges and transiently after switch-off of off-axis ECH in TEXTOR are predicted very well by the paleoclassical model.

  9. Thermophysical and Optical Properties of Semiconducting Ga2Te3 Melt

    NASA Technical Reports Server (NTRS)

    Li, Chao; Su, Ching-Hua; Lehoczky, Sandor L.; Scripa, Rosalie N.; Ban, Heng

    2005-01-01

    The majority of bulk semiconductor single crystals are presently grown from their melts. The thermophysical and optical properties of the melts provide a fundamental understanding of the melt structure and can be used to optimize the growth conditions to obtain higher quality crystals. In this paper, we report several thermophysical and optical properties for Ga2Te3 melts, such as electrical conductivity, viscosity, and optical transmission for temperatures ranging from the melting point up to approximately 990 C. The conductivity and viscosity of the melts are determined using the transient torque technique. The optical transmission of the melts is measured between the wavelengths of 300 and 2000 nm by an dual beam reversed-optics spectrophotometer. The measured properties are in good agreement with the published data. The conductivities indicate that the Ga2Te3 melt is semiconductor-like. The anomalous behavior in the measured properties are used as an indication of a structural transformation in the Ga2Te3 melt and discussed in terms of Eyring's and Bachinskii's predicted behaviors for homogeneous melts.

  10. Conformational Dynamics of Insulin

    PubMed Central

    Hua, Qing-Xin; Jia, Wenhua; Weiss, Michael A.

    2011-01-01

    We have exploited a prandial insulin analog to elucidate the underlying structure and dynamics of insulin as a monomer in solution. A model was provided by insulin lispro (the active component of Humalog®; Eli Lilly and Co.). Whereas NMR-based modeling recapitulated structural relationships of insulin crystals (T-state protomers), dynamic anomalies were revealed by amide-proton exchange kinetics in D2O. Surprisingly, the majority of hydrogen bonds observed in crystal structures are only transiently maintained in solution, including key T-state-specific inter-chain contacts. Long-lived hydrogen bonds (as defined by global exchange kinetics) exist only at a subset of four α-helical sites (two per chain) flanking an internal disulfide bridge (cystine A20–B19); these sites map within the proposed folding nucleus of proinsulin. The anomalous flexibility of insulin otherwise spans its active surface and may facilitate receptor binding. Because conformational fluctuations promote the degradation of pharmaceutical formulations, we envisage that “dynamic re-engineering” of insulin may enable design of ultra-stable formulations for humanitarian use in the developing world. PMID:22649374

  11. New Anomalous Lieb-Robinson Bounds in Quasiperiodic XY Chains

    NASA Astrophysics Data System (ADS)

    Damanik, David; Lemm, Marius; Lukic, Milivoje; Yessen, William

    2014-09-01

    We announce and sketch the rigorous proof of a new kind of anomalous (or sub-ballistic) Lieb-Robinson (LR) bound for an isotropic XY chain in a quasiperiodic transversal magnetic field. Instead of the usual effective light cone |x|≤v|t|, we obtain |x|≤v|t|α for some 0<α <1. We can characterize the allowed values of α exactly as those exceeding the upper transport exponent αu+ of a one-body Schrödinger operator. To our knowledge, this is the first rigorous derivation of anomalous quantum many-body transport. We also discuss anomalous LR bounds with power-law tails for a random dimer field.

  12. On the Casimir scaling violation in the cusp anomalous dimension at small angle

    NASA Astrophysics Data System (ADS)

    Grozin, Andrey; Henn, Johannes; Stahlhofen, Maximilian

    2017-10-01

    We compute the four-loop n f contribution proportional to the quartic Casimir of the QCD cusp anomalous dimension as an expansion for small cusp angle ϕ. This piece is gauge invariant, violates Casimir scaling, and first appears at four loops. It requires the evaluation of genuine non-planar four-loop Feynman integrals. We present results up to O({φ}^4) . One motivation for our calculation is to probe a recent conjecture on the all-order structure of the cusp anomalous dimension. As a byproduct we obtain the four-loop HQET wave function anomalous dimension for this color structure.

  13. Numerical simulation of MPD thruster flows with anomalous transport

    NASA Technical Reports Server (NTRS)

    Caldo, Giuliano; Choueiri, Edgar Y.; Kelly, Arnold J.; Jahn, Robert G.

    1992-01-01

    Anomalous transport effects in an Ar self-field coaxial MPD thruster are presently studied by means of a fully 2D two-fluid numerical code; its calculations are extended to a range of typical operating conditions. An effort is made to compare the spatial distribution of the steady state flow and field properties and thruster power-dissipation values for simulation runs with and without anomalous transport. A conductivity law based on the nonlinear saturation of lower hybrid current-driven instability is used for the calculations. Anomalous-transport simulation runs have indicated that the resistivity in specific areas of the discharge is significantly higher than that calculated in classical runs.

  14. Anomalous Origin of the Right Vertebral Artery: Incidence and Significance.

    PubMed

    Maiti, Tanmoy Kumar; Konar, Subhas Kanti; Bir, Shyamal; Nanda, Anil; Cuellar, Hugo

    2016-05-01

    Detailed knowledge about anatomic variations of the aortic arch and its multiple branches is extremely important to endovascular and diagnostic radiologists. It is often hypothesized that anomalous origin and distribution of large aortic vessels may alter the cerebral hemodynamics and potentially lead to a vascular pathology. In this article, we describe a case of anomalous origin of the right vertebral artery, which was detected during an intervention. We further reviewed the available literature of anomalous origin of the right vertebral artery. The probable embryologic development and clinical significance are discussed. The incidence of anomalous origin of a vertebral artery seems to be underestimated in recent literature. A careful review of the literature shows more than 100 such cases. The right vertebral artery can arise from the aortic arch or one of its branches. Dual origin of the vertebral artery is not uncommon. The embryologic developmental hypotheses are contradictory and complex. Anomalous origin of the right vertebral artery may not be the sole reason behind a disease process. However, it can certainly lead to a misdiagnosis during diagnostic vascular studies. Detailed information is essential for any surgery or endovascular intervention in this location. Copyright © 2015 Elsevier Inc. All rights reserved.

  15. Partial lumbosacral transitional vertebra resection for contralateral facetogenic pain.

    PubMed

    Brault, J S; Smith, J; Currier, B L

    2001-01-15

    Case report of surgically treated mechanical low back pain from the facet joint contralateral to a unilateral anomalous lumbosacral articulation (Bertolotti's syndrome). To describe the clinical presentation, diagnostic evaluation, and management of facet-related low back pain in a 17-year-old cheerleader and its successful surgical treatment with resection of a contralateral anomalous articulation. Lumbosacral transitional vertebrae are common in the general population. Bertolotti's syndrome is mechanical low back pain associated with these transitional segments. Little is known about the pathophysiology and mechanics of these vertebral segments and their propensity to be pain generators. Treatment of this syndrome is controversial, and surgical intervention has been infrequently reported. A retrospective chart analysis and radiographic review were performed. Repeated fluoroscopically guided injections implicated a symptomatic L6-S1 facet joint contralateral to an anomalous lumbosacral articulation. Eventually, a successful surgical outcome was achieved with resection of the anomalous articulation. Clinicians should consider the possibility that mechanical low back pain may occur from a facet contralateral to a unilateral anomalous lumbosacral articulation, even in a young patient. Although reports of surgical treatment of Bertolotti's syndrome are infrequent, resection of the anomalous articulation provided excellent results in this patient, presumably because of reduced stresses on the symptomatic facet.

  16. Change in the tropical cyclone activity around Korea by the East Asian summer monsoon

    NASA Astrophysics Data System (ADS)

    Choi, Jae-Won; Cha, Yumi; Kim, Jeoung-Yun

    2017-12-01

    Correlation between the frequency of summer tropical cyclones (TCs) affecting Korea and the East Asian summer monsoon index (EASMI) was analyzed over the last 37 years. A clear positive correlation existed between the two variables, and this high positive correlation remained unchanged even when excluding El Niño-Southern Oscillation (ENSO) years. To investigate the causes of the positive correlation between the two variables in non-ENSO years, after the 8 years with the highest EASMI (high EASMI years) and the 8 years with the lowest EASMI (low EASMI years) were selected, and the average difference between the two phases was analyzed. In high EASMI years, in the difference between the two phases regarding 850 and 500 hPa streamline, anomalous cyclones were reinforced in the tropical and subtropical western North Pacific, while anomalous anticyclones were reinforced in mid-latitude East Asian areas. Due to these two anomalous pressure systems, anomalous southeasterlies developed near Korea, with these anomalous southeasterlies playing the role of anomalous steering flows making the TCs head toward areas near Korea. In addition, a monsoon trough strengthened more eastward, and TCs in high EASMI years occurred more in east ward over the western North Pacific.

  17. High levels of anomalous self-experience are associated with longer duration of untreated psychosis.

    PubMed

    Haug, Elisabeth; Øie, Merete; Andreassen, Ole A; Bratlien, Unni; Nelson, Barnaby; Melle, Ingrid; Møller, Paul

    2017-04-01

    To investigate the relationship between anomalous self-experiences and duration of untreated psychosis in a sample of patients with first-episode schizophrenia spectrum disorders. Anomalous self-experiences were assessed by means of the Examination of Anomalous Self-Experience manual in 55 patients referred to their first adequate treatment for schizophrenia. Diagnoses, symptom severity, functioning and childhood trauma were assessed using the Structured Clinical Interview for the Positive and Negative Syndrome Scale, Premorbid Adjustment Scale, Social Functioning Scale and Childhood Trauma Questionnaire. Substance misuse was measured with the Drug Use Disorder Identification Test, and alcohol use was measured with the Alcohol Use Disorder Identification Test. Duration of untreated psychosis was measured in accordance with a standardized procedure. High levels of anomalous self-experiences are significantly associated with longer duration of untreated psychosis, an association which held after correcting for other variables associated with long duration of untreated psychosis. The field of early detection in psychosis is in need of additional clinical perspectives to make further progress. Improved understanding and assessment of anomalous self-experiences may help clinicians to detect these important phenomena and provide earlier help, and thus reduce treatment delay. © 2015 Wiley Publishing Asia Pty Ltd.

  18. Contribution of Tropical Cyclones to the Interannual Variability of Baiu Precipitation

    NASA Astrophysics Data System (ADS)

    Yamaura, T.; Tomita, T.

    2011-12-01

    This work examines the contribution of tropical cyclones to the interannual variability of Baiu precipitation with the large-scale interannual variations in the tropics, that is, the El Niño/Southern Oscillation (ENSO) and the Tropospheric Biennial Oscillation (TBO) in the Asian monsoon. The data used are the Global Precipitation Climatology Project, the Japanese 25-year Reanalysis Project/Japan Meteorological Agency Climate Data Assimilation System, and the Joint Typhoon Warning Center. The diagnosed months and the time period are June and July, and 30 years from 1979 to 2008. When the negative precipitation anomalies appear in the entire Baiu front with the cold ENSO phase, the number of tropical cyclones increases around the northern part of the Philippines, and a larger-scale anomalous cyclone is formed there. Tropical cyclones contribute to strengthening the anomalous cyclone. Anomalous convective activity in the anomalous cyclone excites Rossby waves that propagate northward within the low-level jet and form an anomalous anticyclone around Japan. The anomalous anticyclone decreases the Baiu precipitation. On the other hand, the number of tropical cyclones decreases, and an anomalous anticyclone is set around the northern part of the Philippines, when the positive precipitation anomalies are observed in the Baiu front with the warm ENSO phase. The contribution of tropical cyclones is insignificant in this phase. The warm and cold TBO phases are judged from sea surface temperature (SST) anomalies in the equatorial central Pacific that is different from the region for ENSO. In the cold TBO phase with the negative SST anomalies, there appear the negative precipitation anomalies around Kyushu and the positive ones to the southeast of Japan. Concurrently, an anomalous cyclone appears, and the accumulated cyclone energy estimated from the tropical cyclones increases to the southeast of Japan. Tropical cyclones contribute to forming the anomalous cyclone, which shifts the axis of monsoon southwesterlies southward. Thus, the negative precipitation anomalies and the positive ones appear in Kyushu and to the southeast of Japan. In the opposite TBO phase, an anomalous anticyclone is set to the southeast of Japan and suppresses tropical cyclones there. The contribution of tropical cyclones is small in this case. As such, local tropical cyclones contribute to the interannual variation of the Baiu precipitation with larger atmospheric circulations in the western North Pacific.

  19. Evolutionary effects of metalliferous and other anomalous soils in South Central Africa

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wild, H.; Bradshaw, A.D.

    1977-06-01

    The extensive metalliferous and other anomalous soils of South Central Africa have been in existence since before the origin of the angiosperms. So, they should have provided situations in which evolution could have continued uninterrupted, except by major climatic changes, over very long periods. The floras on these areas have therefore been examined, and compared to the situation in Northern Europe. The African anomalous floras could be expected to show: (a) a larger number of species which occupy the anomalous soils; this is certainly true; (b) a greater distinctiveness of the populations tolerating the anomalous soils; there is only amore » little evidence for this; (c) a greater number of tolerant populations which have attained the status of distinct endemic species but which have close relatives; there are a few examples of these; (d) a greater number of tolerant endemic species which have lost their close relatives; there are quite a large number of these, some specific to individual areas of a particular type of anomalous soil. The greater number of endemics is a definite characteristic of the floras. However, despite their great stability, the anomalous areas are not occupied by a flora consisting mostly of endemic species. It is clear that many of the plant populations on the areas must be of recent origin. This suggests that there have been sufficient climatic and other changes to eliminate many of the original colonists and allow the immigration of others.« less

  20. Anomalous Representations of Reality in Luis Valdez's "The Shrunken Head of Pancho Villa" and "The Mummified Deer"

    ERIC Educational Resources Information Center

    Saborio, Linda

    2008-01-01

    Luis Valdez creates anomalous realities in two of his plays, "The Shrunken Head of Pancho Villa" and "The Mummified Deer," in order to defy dominant expressions of reality as well as classifications of "Chicano" and "Mexican." The anomalous realities, represented primarily by a bodiless head in the first play and an eighty-four-year-old Yaqui…

  1. CPC - Climate Weather Linkage: El Niño Southern Oscillation

    Science.gov Websites

    Equatorial Pacific Temperature Depth Anomalies Animation Time longitude section of Anomalous OLR 850 hecto Temperatures anomalies Time series of weekly sea surface temperatures anomalies for the 4 Niño regions Time (OLR) Pentad mean and anomalous OLR Time-longitude section of anomalous OLR 850-hPa Zonal Wind Time

  2. [Anomalous Properties of Water and Aqueous Solutions at Low Temperatures].

    PubMed

    Matsumoto, Masakazu

    2015-01-01

    Water has many anomalous properties below the room temperature. The temperature range overlaps with that of the Earth's atmosphere and also with that natural life forms favor. We review the origin of the anomalous properties of water and aqueous solutions in association with the hypothetical second critical point and liquid-liquid phase separation of water hidden in the supercooled state of liquid water.

  3. Numerical simulations of the impact of hydraulic anisotropy and anthropogenic activities on the complex hydrogeological system of the Lower Yarmouk Gorge

    NASA Astrophysics Data System (ADS)

    Tzoufka, Kalliopi; Siebert, Christian; Rödiger, Tino; Inbar, Nimrod; Shalev, Eyal; Möller, Peter; Raggad, Marwan; Rosenthal, Eliahu; Magri, Fabien

    2017-04-01

    Transient numerical simulations of coupled fluid flow and heat transport processes were conducted, to investigate (i) the impact of hydraulic anisotropy on a complex hydrogeological system and (ii) the anomalous geothermal gradient in the Upper Cretaceous (A7/B2) aquifer of the Lower Yarmouk Gorge (LYG). The N-S directed geological profile starts on the basalt-covered Golan Heights, crosses the LYG and ends at the Jordanian Ajloun Plateau. Heated fresh groundwaters ascend within the LYG from the confined A7/B2 limestone aquifer through artesian Meizar wells and artesian Muhkeibeh well field. A hydrogeological study based on high frequency water-table measurements at the Meizar wells suggested strong impact of abstraction at the Mukheibeh wells on the hydraulic head distribution north of the LYG (Shalev et al., 2015). Contrastingly, hydrochemical investigations conducted in the area concluded that recharge areas of the A7/B2 aquifer are: (i) the foothills of Mountain Hermon, (ii) the Ajloun Plateau and (iii) the Syrian Hauran Plateau, indicating the presence of a zone of high-hydraulic anisotropy along the main LYG axis. Due to this still debatable hydraulic feature, flow along the LYG principle axis is enhanced whilst flow perpendicular to it is constrained (Siebert et al., 2014). In agreement, transient simulations based on a NW-SE profile supported further the hypothesis of a structural feature existent (Magri et al., 2015). The modeled profile cross-cuts the heterogeneous zone and hence the heterogeneity was implemented as an impermeable zone by employing the Equivalent Porous Media approach. Initial 2D models managed to successfully reproduce the natural hydraulic head and temperature distributions. In subsequent simulations, by implementing Meizar abstraction rates, results revealed that mixed convection explains the anomalous temperature gradient in the area as temperature patterns of these simulations are in accordance with a temperature-depth borehole profile. Most significantly, the existence of a zone of anisotropic hydraulic conductivity at the LYG, as suggested above, is supported. Sensitivity analysis of the heterogeneous permeability zone (ranging between 1e-7 m/s and 1e-10 m/s) simultaneously displayed hydraulic connectivity and prevented fluid flux occurrence between the northern and southern LYG flanks. Within the studied aquifer system, aquifer topography directs groundwater flow towards the LYG (N-S and S-N). Once groundwaters reach the zone of hydraulic anisotropy the direction is diverted westwards, towards the Lower Jordan Valley. A final finding pointed to the inadequate size of the A7/B2 drainage basin south of the LYG as the Mukheibeh well field requires a larger drainage area. References Magri, F., Inbar, N., Siebert, C., Rosenthal, E., Guttman, J., Möller, P., 2015. Transient simulations of large-scale hydrogeological processes causing temperature and salinity anomalies in the Tiberias Basin. Journal of Hydrology 520, 342-355. Shalev, E., Malik, U., Lutzky, H., 2015, Monitoring and analysis of water levels and pumping data from Meizar wells, Geological Survey of Israel report, GSI/07/2015 (in Hebrew). Siebert, C., Möller, P., Geyer, S., Kraushaar, S., Dulski, P., Guttman, J., Subah, A., Rödiger, T., 2014. Thermal waters in the Lower Yarmouk Gorge and their relation to surrounding aquifers. Chemie der Erde - Geochemistry 74, 425-441

  4. The Amazon hydrometeorology: Climatology, variability and links to changes in weather patterns

    NASA Astrophysics Data System (ADS)

    Fernandes, Katia De Avila

    My thesis focuses on improving the quantification of the hydrological cycle and understanding the atmospheric processes that link weather to climate in the Amazon River basin. By using ERA40 and independent observations, I assess how well we can estimate the surface water budget in the Amazon River basin. I find that ERA40 basin wide annual precipitation (P) overall agrees with observations showing a slight underestimation of 10% in average, whereas runoff (R) is underestimated by a larger margin (˜25%). Observed residual of precipitation and runoff (denoted as P-R) is better estimated by ERA40 P-R than actual ET which includes soil moisture nudging. The causes for said discrepancies were found to partly relate to soil moisture nudging that needs to be applied during the dry season to produce realistic ET and compensate for the low soil moisture recharge during the previous wet season. Insufficient recharge may in part be caused by underestimation of rainfall amount and intensity; moreover the shallow root layer in the model does not represent the deep soil water reservoir characteristic of the Amazonian forest. Whether the hydrological cycle and weather patterns in the Amazon have changed during the past few decades is a highly debatable but central question for detecting climate change in the region. The second part of my thesis focus on the physical links between rainfall changes detected in observations, and changes of synoptic scale systems as represented by ERA40. My results suggest that an observed delayed wet season onset is consistent with a decreasing number of cold air incursion (CAI) days in southern Amazon for the period 1979--2001. The variability of CAI into southern Amazon is related to the variability of SST upstream of South America in the tropical Pacific and Indian Oceans. A Singular Value Decomposition Analysis (SVD) between CAI days and global SST reveal three main modes of co-variability. The first mode describes the effect of the El Nino-Southern Oscillation. During El Nino (La Nina) a strong (weak) subtropical jet stream over South America tends to prevent transient systems from moving to southern Amazon, resulting in decreased (increased) CAI days during SON. The second mode of co-variability shows an anomalously warm western Indian Ocean also related to strong subtropical jet stream, except the jet is positioned farther north in South America, which along with the absence of a well defined subpolar jet stream, favors the northward displacement of transient waves into central South America, but show little response in southern Amazon. The CAI days reconstructed from the first and second modes do not present any significant trend in southern Amazon. CAI days reconstructed from the third mode of co-variability on the other hand, reproduces the SON observed trend in almost its entirety. The third mode of co-variability describes negative (positive) anomalies in CAI days associated with cold (warm) SST anomalies in the eastern tropical Pacific, anomalous wavetrain in the Southern Hemisphere and Walker Cell displacement that are unfavorable (favorable) to the incursion of CAI into southern Amazon. The temporal evolution of this mode correlates negatively with the Pacific Decadal Oscillation, suggesting that the recent gradual shift in PDO polarity reflected on the interannual response of Southern Pacific atmospheric patterns, hence on the behavior of transients propagation. The negative PDO index and its related atmospheric patterns are in agreement with the reduced observed CAI days, which also related to a delayed wet season onset in the southern Amazon.

  5. Anomalous Hall effect in calcium-doped lanthanum cobaltite and gadolinium

    NASA Astrophysics Data System (ADS)

    Baily, Scott Alan

    The physical origin of the anomalous (proportional to magnetization) Hall effect is not very well understood. While many theories account for a Hall effect proportional to the magnetization of a material, these theories often predict effects significantly smaller than those found in ferromagnetic materials. An even more significant deficiency of the conventional theories is that they predict an anomalous Hall resistivity that is proportional to a power of the resistivity, and in the absence of a metal insulator transition cannot account for the anomalous Hall effect that peaks near TC. Recent models based on a geometric, or Berry, phase have had a great deal of success describing the anomalous Hall effect in double-exchange systems (e.g., lanthanum manganite and chromium dioxide). In gadolinium, as in double-exchange magnets, the exchange interaction is mediated by the conduction electrons and the anomalous Hall effect may therefore resemble that of CrO2 and other metallic double-exchange ferromagnets. Lanthanum cobaltite is similar to manganite in many ways, but a strong double-exchange interaction is not present. Calcium-doped lanthanum cobaltite films were found to have the largest anomalous Hall effect of any ferromagnetic metal. The primary purpose of this study is to gain insight into the origin of the anomalous Hall effect with the hope that these theories can be extended to account for the effect in other materials. The Hall resistivity, magnetoresistance, and magnetization of a Gadolinium single crystal were measured in fields up to 30 T. Cobaltite films were grown via laser ablation and characterized by a variety of techniques. Hall resistivity, magnetoresistance, magnetization, and magnetothermopower of L 1-xCaxCoO3 samples with 0.15 < x < 0.4 were measured in fields up to 7 T. The Gd results suggest that Berry's phase contributes partially to the Hall effect near TC. Berry's phase theories hold promise for explaining the large anomalous Hall effect in La1-xCaxCoO3 near T C, but the material presents many additional complexities, including a unique low temperature magnetoresistance. At low temperature, the Hall effect may be best explained by spin-polarized carriers scattering off of orbital disorder in spin-ordered clusters.

  6. Disentangling Random Motion and Flow in a Complex Medium

    PubMed Central

    Koslover, Elena F.; Chan, Caleb K.; Theriot, Julie A.

    2016-01-01

    We describe a technique for deconvolving the stochastic motion of particles from large-scale fluid flow in a dynamic environment such as that found in living cells. The method leverages the separation of timescales to subtract out the persistent component of motion from single-particle trajectories. The mean-squared displacement of the resulting trajectories is rescaled so as to enable robust extraction of the diffusion coefficient and subdiffusive scaling exponent of the stochastic motion. We demonstrate the applicability of the method for characterizing both diffusive and fractional Brownian motion overlaid by flow and analytically calculate the accuracy of the method in different parameter regimes. This technique is employed to analyze the motion of lysosomes in motile neutrophil-like cells, showing that the cytoplasm of these cells behaves as a viscous fluid at the timescales examined. PMID:26840734

  7. Nondiffusive transport regimes for suprathermal ions in turbulent plasmas

    NASA Astrophysics Data System (ADS)

    Bovet, A.; Fasoli, A.; Ricci, P.; Furno, I.; Gustafson, K.

    2015-04-01

    The understanding of the transport of suprathermal ions in the presence of turbulence is important for fusion plasmas in the burning regime that will characterize reactors, and for space plasmas to understand the physics of particle acceleration. Here, three-dimensional measurements of a suprathermal ion beam in the toroidal plasma device TORPEX are presented. These measurements demonstrate, in a turbulent plasma, the existence of subdiffusive and superdiffusive transport of suprathermal ions, depending on their energy. This result stems from the unprecedented combination of uniquely resolved measurements and first-principles numerical simulations that reveal the mechanisms responsible for the nondiffusive transport. The transport regime is determined by the interaction of the suprathermal ion orbits with the turbulent plasma dynamics, and is strongly affected by the ratio of the suprathermal ion energy to the background plasma temperature.

  8. Model of chromosomal loci dynamics in bacteria as fractional diffusion with intermittent transport

    NASA Astrophysics Data System (ADS)

    Gherardi, Marco; Calabrese, Ludovico; Tamm, Mikhail; Cosentino Lagomarsino, Marco

    2017-10-01

    The short-time dynamics of bacterial chromosomal loci is a mixture of subdiffusive and active motion, in the form of rapid relocations with near-ballistic dynamics. While previous work has shown that such rapid motions are ubiquitous, we still have little grasp on their physical nature, and no positive model is available that describes them. Here, we propose a minimal theoretical model for loci movements as a fractional Brownian motion subject to a constant but intermittent driving force, and compare simulations and analytical calculations to data from high-resolution dynamic tracking in E. coli. This analysis yields the characteristic time scales for intermittency. Finally, we discuss the possible shortcomings of this model, and show that an increase in the effective local noise felt by the chromosome associates to the active relocations.

  9. Thermophoretically driven water droplets on graphene and boron nitride surfaces

    NASA Astrophysics Data System (ADS)

    Rajegowda, Rakesh; Kannam, Sridhar Kumar; Hartkamp, Remco; Sathian, Sarith P.

    2018-05-01

    We investigate thermally driven water droplet transport on graphene and hexagonal boron nitride (h-BN) surfaces using molecular dynamics simulations. The two surfaces considered here have different wettabilities with a significant difference in the mode of droplet transport. The water droplet travels along a straighter path on the h-BN sheet than on graphene. The h-BN surface produced a higher driving force on the droplet than the graphene surface. The water droplet is found to move faster on h-BN surface compared to graphene surface. The instantaneous contact angle was monitored as a measure of droplet deformation during thermal transport. The characteristics of the droplet motion on both surfaces is determined through the moment scaling spectrum. The water droplet on h-BN surface showed the attributes of the super-diffusive process, whereas it was sub-diffusive on the graphene surface.

  10. Simulation of Molecular Transport in Systems Containing Mobile Obstacles.

    PubMed

    Polanowski, Piotr; Sikorski, Andrzej

    2016-08-04

    In this paper, we investigate the movement of molecules in crowded environments with obstacles undergoing Brownian motion by means of extensive Monte Carlo simulations. Our investigations were performed using the dynamic lattice liquid model, which was based on the cooperative movement concept and allowed to mimic systems at high densities where the motion of all elements (obstacles as well as moving particles) were highly correlated. The crowded environments are modeled on a two-dimensional triangular lattice containing obstacles (particles whose mobility was significantly reduced) moving by a Brownian motion. The subdiffusive motion of both elements in the system was analyzed. It was shown that the percolation transition does not exist in such systems in spite of the cooperative character of the particles' motion. The reduction of the obstacle mobility leads to the longer caging of liquid particles by mobile obstacles.

  11. Quantum anomalous Bloch-Siegert shift in Weyl semimetal

    NASA Astrophysics Data System (ADS)

    Kumar, Upendra; Kumar, Vipin; Enamullah, Setlur, Girish S.

    2018-05-01

    A periodic exchange of energy between the light field and two level system is known as Rabi oscillations. The Bloch-Siegert shift (BSS) is a shift in Rabi oscillation resonance condition, when the driving field is sufficiently strong. There are new type of oscillations exhibit in Weyl semimetal at far from resonance, known as anomalous Rabi oscillation. In this work, we study the phenomenon of the Bloch-Siegert shift in Weyl semimetal at far from resonance called anomalous Bloch-Siegert shift (ABSS) by purely quantum mechanical treatment and describe it's anisotropic nature. A fully numerical solution of the Floquet-Bloch equations unequivocally establishes the presence of not only anomalous Rabi oscillations in these systems but also their massless character.

  12. Anomalous right coronary artery arising from the pulmonary artery and constrictive pericarditis: an unusual association

    PubMed Central

    Silvestre, Odilson Marcos; Adam, Eduardo Leal; de Melo, Dirceu Thiago Pessoa; Dias, Ricardo Ribeiro; Ramires, Felix J. A.; Mady, Charles

    2013-01-01

    ABSTRACT The association of anomalous right coronary artery originating from the pulmonary artery and constrictive pericarditis has never been showed in the literature. We present the first case of this unusual association in a patient with right heart failure. After diagnosis, the patient was referred to surgery and underwent phrenic-to-phrenic pericardiectomy; graft implant of right internal thoracic artery to right coronary artery; and ligation of the anomalous origin of the right coronary artery from the pulmonary artery. Such procedures solved the potential risk of sudden death related to anomalous right coronary artery originating from the pulmonary artery and alleviated the symptoms of heart failure caused by constrictive pericarditis. PMID:24136766

  13. No-Drag Frame for Anomalous Chiral Fluid

    DOE PAGES

    Stephanov, Mikhail A.; Yee, Ho-Ung

    2016-03-24

    For an anomalous fluid carrying dissipationless chiral magnetic and/or vortical currents we show that there is a frame in which a stationary obstacle experiences no drag, but energy and charge currents do not vanish, resembling superfluidity. Unlike ordinary superfluid flow, the anomalous chiral currents can transport entropy in this frame. Moreover, we show that the second law of thermodynamics completely determines the amounts of these anomalous nondissipative currents in the “no-drag frame” as polynomials in temperature and chemical potential with known anomaly coefficients. These general results are illustrated and confirmed by a calculation in the chiral kinetic theory and inmore » the quark-gluon plasma at high temperature.« less

  14. Locally distributed crustal deformation in potential areas of phreatic eruptions, detected by InSAR analyses

    NASA Astrophysics Data System (ADS)

    Kobayashi, Tomokazu

    2017-04-01

    Phreatic eruptions may be related to transient pressure changes in subsurface regions of hydrothermal systems attributing a heating of shallow aquifers from magma. It means that crustal deformation presumably proceeds with the pressure increase under the ground, which can be a kind of precursor if it would be detected. One of the most difficult points is that as the eruption size becomes smaller, the precursor signal should be more local, suggesting that it is rather hard to identify the anomaly using conventional ground-based observation tools. To mitigate disaster on phreatic eruptions, an effective proactive monitoring method is desired. One of the tools to overcome the drawbacks is SAR observation. I here report several observation results in which locally distributed crustal deformation has been detected in geothermal areas where phreatic eruptions has occurred recently or historically. One of the most important studies is the case of Mt. Hakone where the crustal deformation has been successfully detected two months before small phreatic eruptions. Mt. Hakone holds an active geothermal area, called Owaku-dani, with active fumaroles although no eruption has been known since 12-13 centuries. However, the anomalous activity such as an increase of seismicity started in the end of April, 2015. With this anomalous activity, SAR (ALOS-2) observations have been conducted, and small but significant crustal deformation has been detected in a local area with a diameter of 200 m with a displacement of 5 cm. The amount of deformation has increased with time although the spatial size has not changed, and resultantly the amount reached up to 60 cm. Finally, in the end of June, eruptions occurred just at the local crustal deformation area. It should be noted that the eruption started from the InSAR-detected inflational area. This is an excellent case that we were able to identify the location of small phreatic eruption in advance by detecting anomalous ground inflation. It is also noted that the detection of the precursory signal has contributed to the administrative decision making such as setting up no-go area. In this presentation, in addition to this case, I will show some local ground inflational signals observed in geothermal areas where eruptions have not occurred as yet. Acknowledgements: ALOS-2 data were provided under a cooperative contract with JAXA (Japan Aerospace Exploration Agency). The ownership of ALOS-2 data belongs to JAXA. This study was supported by JSPS KAKENHI Grant Numbers JP16K17797 and JP25350494.

  15. A Search for New Galactic Magnetars in Archival Chandra and XMM-Newton Observations

    NASA Astrophysics Data System (ADS)

    Muno, M. P.; Gaensler, B. M.; Nechita, A.; Miller, J. M.; Slane, P. O.

    2008-06-01

    We present constraints on the number of Galactic magnetars, which we have established by searching for sources with periodic variability in 506 archival Chandra observations and 441 archival XMM-Newton observations of the Galactic plane (| b| < 5°). Our search revealed four sources with periodic variability on timescales of 200-5000 s, all of which are probably accreting white dwarfs. We identify 7 of 12 known Galactic magnetars, but find no new examples with periods between 5 and 20 s. We convert this nondetection into limits on the total number of Galactic magnetars by computing the fraction of the young Galactic stellar population that our survey covered. We find that easily detectable magnetars, modeled after persistent anomalous X-ray pulsars (e.g., with LX = 1035 ergs s-1 [0.5-10.0 keV] and Arms = 12% ), could have been identified in ≈5% of the Galactic spiral arms by mass. If we assume that three previously known examples randomly fall within our survey, then there are 59+ 92-32 in the Galaxy. Barely detectable magnetars (LX = 3 × 1033 ergs s-1 and Arms = 15% ) could have been identified throughout ≈0.4% of the spiral arms. The lack of new examples implies that <540 exist in the Galaxy (90% confidence). Similar constraints are found by considering the detectability of transient magnetars in outburst. For assumed lifetimes of 104 yr, the birth rate of magnetars is between 0.003 and 0.06 yr-1. Therefore, the birth rate of magnetars is at least 10% of that for normal radio pulsars, and could exceed that value, unless transient magnetars are active for gtrsim105 yr.

  16. Assessing historical rate changes in global tsunami occurrence

    USGS Publications Warehouse

    Geist, E.L.; Parsons, T.

    2011-01-01

    The global catalogue of tsunami events is examined to determine if transient variations in tsunami rates are consistent with a Poisson process commonly assumed for tsunami hazard assessments. The primary data analyzed are tsunamis with maximum sizes >1m. The record of these tsunamis appears to be complete since approximately 1890. A secondary data set of tsunamis >0.1m is also analyzed that appears to be complete since approximately 1960. Various kernel density estimates used to determine the rate distribution with time indicate a prominent rate change in global tsunamis during the mid-1990s. Less prominent rate changes occur in the early- and mid-20th century. To determine whether these rate fluctuations are anomalous, the distribution of annual event numbers for the tsunami catalogue is compared to Poisson and negative binomial distributions, the latter of which includes the effects of temporal clustering. Compared to a Poisson distribution, the negative binomial distribution model provides a consistent fit to tsunami event numbers for the >1m data set, but the Poisson null hypothesis cannot be falsified for the shorter duration >0.1m data set. Temporal clustering of tsunami sources is also indicated by the distribution of interevent times for both data sets. Tsunami event clusters consist only of two to four events, in contrast to protracted sequences of earthquakes that make up foreshock-main shock-aftershock sequences. From past studies of seismicity, it is likely that there is a physical triggering mechanism responsible for events within the tsunami source 'mini-clusters'. In conclusion, prominent transient rate increases in the occurrence of global tsunamis appear to be caused by temporal grouping of geographically distinct mini-clusters, in addition to the random preferential location of global M >7 earthquakes along offshore fault zones.

  17. Magnetars: the physics behind observations. A review

    NASA Astrophysics Data System (ADS)

    Turolla, R.; Zane, S.; Watts, A. L.

    2015-11-01

    Magnetars are the strongest magnets in the present universe and the combination of extreme magnetic field, gravity and density makes them unique laboratories to probe current physical theories (from quantum electrodynamics to general relativity) in the strong field limit. Magnetars are observed as peculiar, burst-active x-ray pulsars, the anomalous x-ray pulsars (AXPs) and the soft gamma repeaters (SGRs); the latter emitted also three ‘giant flares’, extremely powerful events during which luminosities can reach up to 1047erg s-1 for about one second. The last five years have witnessed an explosion in magnetar research which has led, among other things, to the discovery of transient, or ‘outbursting’, and ‘low-field’ magnetars. Substantial progress has been made also on the theoretical side. Quite detailed models for explaining the magnetars’ persistent x-ray emission, the properties of the bursts, the flux evolution in transient sources have been developed and confronted with observations. New insight on neutron star asteroseismology has been gained through improved models of magnetar oscillations. The long-debated issue of magnetic field decay in neutron stars has been addressed, and its importance recognized in relation to the evolution of magnetars and to the links among magnetars and other families of isolated neutron stars. The aim of this paper is to present a comprehensive overview in which the observational results are discussed in the light of the most up-to-date theoretical models and their implications. This addresses not only the particular case of magnetar sources, but the more fundamental issue of how physics in strong magnetic fields can be constrained by the observations of these unique sources.

  18. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cleaver, G.B.; Faraggi, A.E.

    The realistic free fermionic models have had an intriguing success in explaining different properties of the observed particle spectrum. In this paper the authors discuss in some detail the anomalous U(1) symmetry which exists in these models. They study the properties of the anomalous U(1) in both the more realistic NAHE-based free fermionic models and those in a general NAHE class. Appearance of an anomalous U(1) in the more realistic NAHE models is shown to be an effect of reduction of world-sheet supersymmetry from (2,2) to (2,0). They show, however, that in more general (2,1) and (2,0) models, all U(1)more » can remain anomaly-free under certain conditions. Several phenomenological issues related to the anomalous U(1) are discussed. In particular, they note that in some examples the anomalous U(1) arises from the breaking E{sub 6} {yields} SO(10) {times} U(1){sub A}, resulting in U(1){sub A} being family universal.« less

  19. Report of reprocessing of reflection seismic profile X-5 Waste Isolation Pilot Plant site, Eddy County, New Mexico

    USGS Publications Warehouse

    Miller, John J.

    1983-01-01

    Seismic reflection profile X-5 exhibits a 7,700 ft long anomalous zone of poor quality to nonexistent reflections between shotpoints 100 and 170, compared to the high-quality, flat-lying, coherent reflections on either side. Results from drill holes in the area suggest 'layer cake' geology with no detectable abnormalities such as faults present. In an attempt to determine whether the anomalous zone of the seismic profile is an artifact or actually indicates a geologic condition, the data were extensively reprocessed using state-of-the-art processing techniques and the following conclusions were made: 1. The field-recorded data in the anomalous zone are of poor quality due to surface conditions and recording parameters used. 2. Reprocessing shows reflectors throughout the anomalous zone at all levels. However, it cannot prove that the reflectors are continuous throughout the anomalous zone. 3. Significant improvement in data quality may be achieved if the line is reshot using carefully determined recording parameters.

  20. Underdamped scaled Brownian motion: (non-)existence of the overdamped limit in anomalous diffusion.

    PubMed

    Bodrova, Anna S; Chechkin, Aleksei V; Cherstvy, Andrey G; Safdari, Hadiseh; Sokolov, Igor M; Metzler, Ralf

    2016-07-27

    It is quite generally assumed that the overdamped Langevin equation provides a quantitative description of the dynamics of a classical Brownian particle in the long time limit. We establish and investigate a paradigm anomalous diffusion process governed by an underdamped Langevin equation with an explicit time dependence of the system temperature and thus the diffusion and damping coefficients. We show that for this underdamped scaled Brownian motion (UDSBM) the overdamped limit fails to describe the long time behaviour of the system and may practically even not exist at all for a certain range of the parameter values. Thus persistent inertial effects play a non-negligible role even at significantly long times. From this study a general questions on the applicability of the overdamped limit to describe the long time motion of an anomalously diffusing particle arises, with profound consequences for the relevance of overdamped anomalous diffusion models. We elucidate our results in view of analytical and simulations results for the anomalous diffusion of particles in free cooling granular gases.

  1. Application of focused-beam flat-sample method to synchrotron powder X-ray diffraction with anomalous scattering effect

    NASA Astrophysics Data System (ADS)

    Tanaka, M.; Katsuya, Y.; Matsushita, Y.

    2013-03-01

    The focused-beam flat-sample method (FFM), which is a method for high-resolution and rapid synchrotron X-ray powder diffraction measurements by combination of beam focusing optics, a flat shape sample and an area detector, was applied for diffraction experiments with anomalous scattering effect. The advantages of FFM for anomalous diffraction were absorption correction without approximation, rapid data collection by an area detector and good signal-to-noise ratio data by focusing optics. In the X-ray diffraction experiments of CoFe2O4 and Fe3O4 (By FFM) using X-rays near the Fe K absorption edge, the anomalous scattering effect between Fe/Co or Fe2+/Fe3+ can be clearly detected, due to the change of diffraction intensity. The change of observed diffraction intensity as the incident X-ray energy was consistent with the calculation. The FFM is expected to be a method for anomalous powder diffraction.

  2. Rietveld analysis using powder diffraction data with anomalous scattering effect obtained by focused beam flat sample method

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tanaka, Masahiko, E-mail: masahiko@spring8.or.jp; Katsuya, Yoshio, E-mail: katsuya@spring8.or.jp; Sakata, Osami, E-mail: SAKATA.Osami@nims.go.jp

    2016-07-27

    Focused-beam flat-sample method (FFM) is a new trial for synchrotron powder diffraction method, which is a combination of beam focusing optics, flat shape powder sample and area detectors. The method has advantages for X-ray diffraction experiments applying anomalous scattering effect (anomalous diffraction), because of 1. Absorption correction without approximation, 2. High intensity X-rays of focused incident beams and high signal noise ratio of diffracted X-rays 3. Rapid data collection with area detectors. We applied the FFM to anomalous diffraction experiments and collected synchrotron X-ray powder diffraction data of CoFe{sub 2}O{sub 4} (inverse spinel structure) using X-rays near Fe K absorptionmore » edge, which can distinguish Co and Fe by anomalous scattering effect. We conducted Rietveld analyses with the obtained powder diffraction data and successfully determined the distribution of Co and Fe ions in CoFe{sub 2}O{sub 4} crystal structure.« less

  3. Summary geochemical maps for samples of rock, stream sediment, and nonmagnetic heavy-mineral concentrate, Sweetwater Roadless Area, Mono County, California and Lyon and Douglas Counties, Nevada

    USGS Publications Warehouse

    Chaffee, Maurice A.

    1986-01-01

    Map A shows the locations of all sites where rock samples were collected for this report and the distributions of anomalous concentrations for 12 elements in the 127 rock samples collected. In a similar manner, map B shows the collection sites for 59 samples of minus-60-mesh stream sediment, and 59 samples of nonmagnetic heavy-mineral concentrate derived from stream sediment and also shows the distributions of anomalous concentrations for 13 elements in the stream-sediment samples and 17 elements in the concentrate samples. Map C shows outlines of those drainage basins containing samples of stream sediment and concentrate with anomalous element concentrations and also shows weighted values for each outlined basin based on the number of elements with anomalous concentrations in each stream-sediment and concentrate sample and on the degree to which these concentrations are anomalous in each sample.

  4. Multi-Level Modeling of Complex Socio-Technical Systems - Phase 1

    DTIC Science & Technology

    2013-06-06

    is to detect anomalous organizational outcomes, diagnose the causes of these anomalies , and decide upon appropriate compensation schemes. All of...monitor process outcomes. The purpose of this monitoring is to detect anomalous process outcomes, diagnose the causes of these anomalies , and decide upon...monitor work outcomes in terms of performance. The purpose of this monitoring is to detect anomalous work outcomes, diagnose the causes of these anomalies

  5. Magnetic resonance imaging in the assessment of anomalous pulmonary venous connections.

    PubMed

    Bernal Garnes, N; Méndez Díaz, C; Soler Fernández, R; Rodríguez García, E

    2016-01-01

    To illustrate the morphological and functional magnetic resonance findings for total and partial anomalous pulmonary venous connections as well as of the most common complications after surgery. The magnetic resonance findings are fundamental in defining the type of anomalous connection, deciding on the treatment, planning the surgery, and detecting postsurgical complications. Copyright © 2015 SERAM. Published by Elsevier España, S.L.U. All rights reserved.

  6. Anomalous vibrational modes in acetanilide as studied by inelastic neutron scattering

    NASA Astrophysics Data System (ADS)

    Barthes, Mariette; Eckert, Juegen; Johnson, Susanna W.; Moret, Jacques; Swanson, Basil I.; Unkefer, Clifford J.

    1992-10-01

    A study of the anomalous modes in acetanilide and five deuterated derivatives by incoherent inelastic neutron scattering is reported. These data show that the dynamics of the amide and methyl groups influence each other. In addition, the anomalous temperature behaviour of the NH out-of-plane bending mode is confirmed. These observations suggest that the self-trapping mechanism in ACN may be more complex than hitherto assumed.

  7. Anomalous Nernst and Hall effects in magnetized platinum and palladium

    NASA Astrophysics Data System (ADS)

    Guo, G. Y.; Niu, Q.; Nagaosa, N.

    2014-06-01

    We study the anomalous Nernst effect (ANE) and anomalous Hall effect (AHE) in proximity-induced ferromagnetic palladium and platinum which is widely used in spintronics, within the Berry phase formalism based on the relativistic band-structure calculations. We find that both the anomalous Hall (σxyA) and Nernst (αxyA) conductivities can be related to the spin Hall conductivity (σxyS) and band exchange splitting (Δex) by relations σxyA=ΔexeℏσxyS(EF)' and αxyA=-π23kB2TΔexℏσxys(μ )'', respectively. In particular, these relations would predict that the σxyA in the magnetized Pt (Pd) would be positive (negative) since the σxyS(EF)' is positive (negative). Furthermore, both σxyA and αxyA are approximately proportional to the induced spin magnetic moment (ms) because the Δex is a linear function of ms. Using the reported ms in the magnetized Pt and Pd, we predict that the intrinsic anomalous Nernst conductivity (ANC) in the magnetic platinum and palladium would be gigantic, being up to ten times larger than, e.g., iron, while the intrinsic anomalous Hall conductivity (AHC) would also be significant.

  8. Anomalous U(1) models in four and five dimensions and their anomaly poles

    NASA Astrophysics Data System (ADS)

    Armillis, Roberta; Corianò, Claudio; Delle Rose, Luigi; Guzzi, Marco

    2009-12-01

    We analyze the role played by anomaly poles in an anomalous gauge theory by discussing their signature in the corresponding off-shell effective action. The origin of these contributions, in the most general kinematical case, is elucidated by performing a complete analysis of the anomaly vertex at perturbative level. We use two independent (but equivalent) representations: the Rosenberg representation and the longitudinal/transverse (L/T) parameterization, used in recent studies of g-2 of the muon and in the proof of non-renormalization theorems of the anomaly vertex. The poles extracted from the L/T parameterization do not couple in the infrared for generic anomalous vertices, as in Rosenberg, but we show that they are responsible for the violations of unitarity in the UV region, using a class of pole-dominated amplitudes. We conclude that consistent formulations of anomalous models require necessarily the cancellation of these polar contributions. Establishing the UV significance of these terms provides a natural bridge between the anomalous effective action and its completion by a nonlocal theory. Some additional difficulties with unitarity of the mechanism of inflow in extra dimensional models with an anomalous theory on the brane, due to the presence of anomaly poles, are also pointed out.

  9. Intraductal papillary neoplasm originating from an anomalous bile duct.

    PubMed

    Maki, Harufumi; Aoki, Taku; Ishizawa, Takeaki; Tanaka, Mariko; Sakatani, Takashi; Beck, Yoshifumi; Hasegawa, Kiyoshi; Sakamoto, Yoshihiro; Kokudo, Norihiro

    2017-04-01

    An 82-year-old woman who had been suffering from repeated obstructive jaundice for 7 years was referred to our hospital. Although endoscopic aspiration of the mucin in the common bile duct had been temporally effective, origin of the mucin production had not been detectable. The patient thus had been forced to be on long-term follow-up without curative resection. Endoscopic retrograde cholangioscopy on admission revealed massive mucin in the common bile duct. In addition, an anomalous bile duct located proximal to the gallbladder was identified. Since the lumen of the anomalous duct was irregular and the rest of biliary tree was completely free of suspicious lesions, the anomalous duct was judged to be the primary site. Surgical resection of the segment 4 and 5 of the liver combined with the extrahepatic biliary tract was performed. Pathological diagnosis was compatible to intraductal papillary neoplasm with high-grade intraepithelial dysplasia of the anomalous bile duct. The patient has been free from the disease for 6.5 years after resection. This is the first case of intraductal papillary neoplasm derived from an anomalous bile duct, which was resected after long-term conservative treatment. The present case suggested the slow growing character of natural history of the neoplasm.

  10. Revisiting point FRAP to quantitatively characterize anomalous diffusion in live cells.

    PubMed

    Daddysman, Matthew K; Fecko, Christopher J

    2013-02-07

    Fluorescence recovery after photobleaching (FRAP) is widely used to interrogate diffusion and binding of proteins in live cells. Herein, we apply two-photon excited FRAP with a diffraction limited bleaching and observation volume to study anomalous diffusion of unconjugated green fluorescence protein (GFP) in vitro and in cells. Experiments performed on dilute solutions of GFP reveal that reversible fluorophore bleaching can be mistakenly interpreted as anomalous diffusion. We derive a reaction-diffusion FRAP model that includes reversible photobleaching, and demonstrate that it properly accounts for these photophysics. We then apply this model to investigate the diffusion of GFP in HeLa cells and polytene cells of Drosophila larval salivary glands. GFP exhibits anomalous diffusion in the cytoplasm of both cell types and in HeLa nuclei. Polytene nuclei contain optically resolvable chromosomes, permitting FRAP experiments that focus separately on chromosomal or interchrosomal regions. We find that GFP exhibits anomalous diffusion in chromosomal regions but diffuses normally in regions devoid of chromatin. This observation indicates that obstructed transport through chromatin and not crowding by macromolecules is a source of anomalous diffusion in polytene nuclei. This behavior is likely true in other cells, so it will be important to account for this type of transport physics and for reversible photobleaching to properly interpret future FRAP experiments on DNA-binding proteins.

  11. Against the odds? De novo structure determination of a pilin with two cysteine residues by sulfur SAD.

    PubMed

    Gorgel, Manuela; Bøggild, Andreas; Ulstrup, Jakob Jensen; Weiss, Manfred S; Müller, Uwe; Nissen, Poul; Boesen, Thomas

    2015-05-01

    Exploiting the anomalous signal of the intrinsic S atoms to phase a protein structure is advantageous, as ideally only a single well diffracting native crystal is required. However, sulfur is a weak anomalous scatterer at the typical wavelengths used for X-ray diffraction experiments, and therefore sulfur SAD data sets need to be recorded with a high multiplicity. In this study, the structure of a small pilin protein was determined by sulfur SAD despite several obstacles such as a low anomalous signal (a theoretical Bijvoet ratio of 0.9% at a wavelength of 1.8 Å), radiation damage-induced reduction of the cysteines and a multiplicity of only 5.5. The anomalous signal was improved by merging three data sets from different volumes of a single crystal, yielding a multiplicity of 17.5, and a sodium ion was added to the substructure of anomalous scatterers. In general, all data sets were balanced around the threshold values for a successful phasing strategy. In addition, a collection of statistics on structures from the PDB that were solved by sulfur SAD are presented and compared with the data. Looking at the quality indicator R(anom)/R(p.i.m.), an inconsistency in the documentation of the anomalous R factor is noted and reported.

  12. Anomalous Hall effect in semiconductor quantum wells in proximity to chiral p -wave superconductors

    NASA Astrophysics Data System (ADS)

    Yang, F.; Yu, T.; Wu, M. W.

    2018-05-01

    By using the gauge-invariant optical Bloch equation, we perform a microscopic kinetic investigation on the anomalous Hall effect in chiral p -wave superconducting states. Specifically, the intrinsic anomalous Hall conductivity in the absence of the magnetic field is zero as a consequence of Galilean invariance in our description. As for the extrinsic channel, a finite anomalous Hall current is obtained from the impurity scattering with the optically excited normal quasiparticle current even at zero temperature. From our kinetic description, it can be clearly seen that the excited normal quasiparticle current is due to an induced center-of-mass momentum of Cooper pairs through the acceleration driven by ac electric field. For the induced anomalous Hall current, we show that the conventional skew-scattering channel in the linear response makes the dominant contribution in the strong impurity interaction. In this case, our kinetic description as a supplementary viewpoint mostly confirms the results of Kubo formalism in the literature. Nevertheless, in the weak impurity interaction, this skew-scattering channel becomes marginal and we reveal that an induction channel from the Born contribution dominates the anomalous Hall current. This channel, which has long been overlooked in the literature, is due to the particle-hole asymmetry by nonlinear optical excitation. Finally, we study the case in the chiral p -wave superconducting state with a transverse conical magnetization, which breaks the Galilean invariance. In this situation, the intrinsic anomalous Hall conductivity is no longer zero. Comparison of this intrinsic channel with the extrinsic one from impurity scattering is addressed.

  13. A Falling Corona Model for the Anomalous Behavior of the Broad Emission Lines in NGC 5548

    NASA Astrophysics Data System (ADS)

    Sun, Mouyuan; Xue, Yongquan; Cai, Zhenyi; Guo, Hengxiao

    2018-04-01

    NGC 5548 has been intensively monitored by the AGN Space Telescope and Optical Reverberation Mapping collaboration. Approximately after half of the light curves, the correlation between the broad emission lines and the lag-corrected ultraviolet (UV) continua becomes weak. This anomalous behavior is accompanied by an increase of soft X-ray emission. We propose a simple model to understand this anomalous behavior, i.e., the corona might fall down, thereby increasing the covering fraction of the inner disk. Therefore, X-ray and extreme-UV emission suffer from spectral variations. The UV continua variations are driven by both X-ray and extreme-UV variations. Consequently, the spectral variability induced by the falling corona would dilute the correlation between the broad emission lines and the UV continua. Our model can explain many additional observational facts, including the dependence of the anomalous behavior on velocity and ionization energy. We also show that the time lag and correlation between the X-ray and the UV variations change as NGC 5548 displays the anomalous behavior. The time lag is dramatically longer than the expectation from disk reprocessing if the anomalous behavior is properly excluded. During the anomalous state, the time lag approaches the light-travel timescale of disk reprocessing albeit with a much weaker correlation. We speculate that the time lag in the normal state is caused by reprocessing of the broad line region gas. As NGC 5548 enters the abnormal state, the contribution of the broad line region gas is smaller; the time lag reflects disk reprocessing. We also discuss alternative scenarios.

  14. Anomalous CO2 Emissions in Different Ecosystems Around the World

    NASA Astrophysics Data System (ADS)

    Sanchez-Canete, E. P.; Moya Jiménez, M. R.; Kowalski, A. S.; Serrano-Ortiz, P.; López-Ballesteros, A.; Oyonarte, C.; Domingo, F.

    2016-12-01

    As an important tool for understanding and monitoring ecosystem dynamics at ecosystem level, the eddy covariance (EC) technique allows the assessment of the diurnal and seasonal variation of the net ecosystem exchange (NEE). Despite the high temporal resolution data available, there are still many processes (in addition to photosynthesis and respiration) that, although they are being monitored, have been neglected. Only a few authors have studied anomalous CO2 emissions (non biological), and have related them to soil ventilation, photodegradation or geochemical processes. The aim of this study is: 1) to identify anomalous short term CO2 emissions in different ecosystems distributed around the world, 2) to determine the meteorological variables that are influencing these emissions, and 3) to explore the potential processes that can be involved. We have studied EC data together with other meteorological ancillary variables obtained from the FLUXNET database (version 2015) and have found more than 50 sites with anomalous CO2 emissions in different ecosystem types such as grasslands, croplands or savannas. Data were filtered according to the FLUXNET quality control flags (only data with quality control flag equal to 0 was used) and correlation analysis were performed with NEE and ancillary data. Preliminary results showed strong and highly significant correlations between meteorological variables and anomalous CO2 emissions. Correlation results showed clear differing behaviors between ecosystems types, which could be related to the different processes involved in the anomalous CO2 emissions. We suggest that anomalous CO2 emissions are happening globally and therefore, their contribution to the global net ecosystem carbon balance requires further investigation in order to better understand its drivers.

  15. Anomalous Signal Detection in ELF Band Electromagnetic Wave using Multi-layer Neural Network with Wavelet Decomposition

    NASA Astrophysics Data System (ADS)

    Itai, Akitoshi; Yasukawa, Hiroshi; Takumi, Ichi; Hata, Masayasu

    It is well known that electromagnetic waves radiated from the earth's crust are useful for predicting earthquakes. We analyze the electromagnetic waves received at the extremely low frequency band of 223Hz. These observed signals contain the seismic radiation from the earth's crust, but also include several undesired signals. Our research focuses on the signal detection technique to identify an anomalous signal corresponding to the seismic radiation in the observed signal. Conventional anomalous signal detections lack a wide applicability due to their assumptions, e.g. the digital data have to be observed at the same time or the same sensor. In order to overcome the limitation related to the observed signal, we proposed the anomalous signals detection based on a multi-layer neural network which is trained by digital data observed during a span of a day. In the neural network approach, training data do not need to be recorded at the same place or the same time. However, some noises, which have a large amplitude, are detected as the anomalous signal. This paper develops a multi-layer neural network to decrease the false detection of the anomalous signal from the electromagnetic wave. The training data for the proposed network is the decomposed signal of the observed signal during several days, since the seismic radiations are often recorded from several days to a couple of weeks. Results show that the proposed neural network is useful to achieve the accurate detection of the anomalous signal that indicates seismic activity.

  16. Computerized simulation of color appearance for anomalous trichromats using the multispectral image.

    PubMed

    Yaguchi, Hirohisa; Luo, Junyan; Kato, Miharu; Mizokami, Yoko

    2018-04-01

    Most color simulators for color deficiencies are based on the tristimulus values and are intended to simulate the appearance of an image for dichromats. Statistics show that there are more anomalous trichromats than dichromats. Furthermore, the spectral sensitivities of anomalous cones are different from those of normal cones. Clinically, the types of color defects are characterized through Rayleigh color matching, where the observer matches a spectral yellow to a mixture of spectral red and green. The midpoints of the red/green ratios deviate from a normal trichromat. This means that any simulation based on the tristimulus values defined by a normal trichromat cannot predict the color appearance of anomalous Rayleigh matches. We propose a computerized simulation of the color appearance for anomalous trichromats using multispectral images. First, we assume that anomalous trichromats possess a protanomalous (green shifted) or deuteranomalous (red shifted) pigment instead of a normal (L or M) one. Second, we assume that the luminance will be given by L+M, and red/green and yellow/blue opponent color stimulus values are defined through L-M and (L+M)-S, respectively. Third, equal-energy white will look white for all observers. The spectral sensitivities of the luminance and the two opponent color channels are multiplied by the spectral radiance of each pixel of a multispectral image to give the luminance and opponent color stimulus values of the entire image. In the next stage of color reproduction for normal observers, the luminance and two opponent color channels are transformed into XYZ tristimulus values and then transformed into sRGB to reproduce a final image for anomalous trichromats. The proposed simulation can be used to predict the Rayleigh color matches for anomalous trichromats. We also conducted experiments to evaluate the appearance of simulated images by color deficient observers and verified the reliability of the simulation.

  17. Shrinking of core neoclassical tearing mode magnetic islands due to edge localized modes and the role of ion-scale turbulence in island recovery in DIII-D

    NASA Astrophysics Data System (ADS)

    Bardóczi, L.; Rhodes, T. L.; Carter, T. A.; La Haye, R. J.; Bañón Navarro, A.; McKee, G. R.

    2017-06-01

    Experimental signature of long-wavelength turbulence accelerating the recovery of Neoclassical Tearing Mode (NTM) magnetic islands after they have been transiently reduced in size due to interaction with Edge Localized Modes (ELMs) is reported for the first time. This work shows that perturbations associated with ELMs result in peaking of the electron temperature (Te) in the O-point region of saturated core m/n = 2/1 islands (m/n being the poloidal/toroidal mode numbers). In synchronization with this Te peak, the island width shrinks by as much as 30% suggesting a key role of the Te peak in NTM stability due to modified pressure gradient (∇p) and perturbed bootstrap current (δjBS) at the O-point. Next, this Te peak relaxes via anomalous transport (i.e., the diffusivity is 2 orders of magnitude larger than the neoclassical value) and the island recovers. Long-wavelength turbulent density fluctuations ( n ˜ ) are reduced at the O-point of flat islands but these fluctuations are increased when Te is peaked which offers an explanation for the observed anomalous transport that is responsible for the relaxation of the Te peak. Linear gyrokinetic simulations indicate that n ˜ inside the peaked island is dominantly driven by the Ion Temperature Gradient instability. These measurements suggest that n ˜ accelerates NTM recovery after an ELM crash via accelerating the relaxation of ∇p at the O-point. These observations are qualitatively replicated by coupled predator-prey equations and modified Rutherford equation. In this simple model, turbulence accelerates NTM recovery via relaxing ∇p and therefore restoring δjBS at the O-point. The key physics of the relationship between the Te peak and NTM stability has potentially far-reaching consequences, such as NTM control via pellet injection in high-β tokamak plasmas.

  18. Higher-order phase transitions on financial markets

    NASA Astrophysics Data System (ADS)

    Kasprzak, A.; Kutner, R.; Perelló, J.; Masoliver, J.

    2010-08-01

    Statistical and thermodynamic properties of the anomalous multifractal structure of random interevent (or intertransaction) times were thoroughly studied by using the extended continuous-time random walk (CTRW) formalism of Montroll, Weiss, Scher, and Lax. Although this formalism is quite general (and can be applied to any interhuman communication with nontrivial priority), we consider it in the context of a financial market where heterogeneous agent activities can occur within a wide spectrum of time scales. As the main general consequence, we found (by additionally using the Saddle-Point Approximation) the scaling or power-dependent form of the partition function, Z(q'). It diverges for any negative scaling powers q' (which justifies the name anomalous) while for positive ones it shows the scaling with the general exponent τ(q'). This exponent is the nonanalytic (singular) or noninteger power of q', which is one of the pilar of higher-order phase transitions. In definition of the partition function we used the pausing-time distribution (PTD) as the central one, which takes the form of convolution (or superstatistics used, e.g. for describing turbulence as well as the financial market). Its integral kernel is given by the stretched exponential distribution (often used in disordered systems). This kernel extends both the exponential distribution assumed in the original version of the CTRW formalism (for description of the transient photocurrent measured in amorphous glassy material) as well as the Gaussian one sometimes used in this context (e.g. for diffusion of hydrogen in amorphous metals or for aging effects in glasses). Our most important finding is the third- and higher-order phase transitions, which can be roughly interpreted as transitions between the phase where high frequency trading is most visible and the phase defined by low frequency trading. The specific order of the phase transition directly depends upon the shape exponent α defining the stretched exponential integral kernel. On this basis a simple practical hint for investors was formulated.

  19. COS FUV Recovery after Anomalous Shutdown

    NASA Astrophysics Data System (ADS)

    Wheeler, Thomas

    2012-10-01

    This proposal consists of the steps for turning on and ramping up the COS FUV high voltage in a conservative manner after a HV anomalous shutdown by executing a "reduced set" of visits from Cycle 19 Proposal 12810. The nature of the shutdown, i.e., over-light, HV current transient {"crackle"}, ion feedback {induced by a high energy particle}, or field emission {possibly caused by dust or other particulate on the QE grid or other close-by structure or hardware}, and the value of the commanded HV at the time of the shutdown will determine what visits are executed. Because of gain sag, commanded HV settings updates may be required. First, prior to execution of this proposal or selected visits from this proposal, all preliminary steps should be exercised to gather the necessary diagnostic data, e.g., science data evaluation {if a science exposure was in progress and the science data is available}, memory dumps {DCE, EXEC RAM, and possibly the CS BUFFER}, engineering telemetry, or other information that might provide insight as to the nature of the shutdown and estimated count rate. The complete step-by-step procedure is detailed in the Observing Description, but in summary, the following is done:Day 01 activities, visits 01-07, contain both QE grid off and on HV ramping to HVLow {100/100} with diagnostics {DCE dumps} and darks to exclude QE grid involvement in the shutdown. Subsequent to day 01, all HV ramping will be with the QE grid on with the same diagnostics and exposures. All days end with the setting of COS event flag 3 to prevent any FUV HV commanding.Time is allotted for cognizant detector and COS instrument scientist and engineers to examine data dumps, science exposures, and engineering telemetry. If all is well, the go-ahead will be given to clear flag 3 for the next day's visits.This proposal is modeled after the Cycle 19 Proposal 12718.

  20. COS FUV Recovery after Anomalous Shutdown

    NASA Astrophysics Data System (ADS)

    Wheeler, Thomas

    2013-10-01

    This proposal consists of the steps for turning on and ramping up the COS FUV high voltage in a safe and conservative manner after a HV anomalous shutdown by executing a "reduced set" of visits from Cycle 19 Proposal 12810. The nature of the shutdown, i.e., over-light, HV current transient {"crackle"}, ion feedback {induced by a high energy particle}, or field emission {possibly caused by dust or other particulate on the QE grid or other close-by structure or hardware}, and the value of the commanded HV at the time of the shutdown will determine what visits are executed. Because of gain sag, commanded HV settings updates may be required. First, prior to execution of this proposal or selected visits from this proposal, all preliminary steps should be exercised to gather the necessary diagnostic data, e.g., science data evaluation {if a science exposure was in progress and the science data is available}, memory dumps {DCE, EXEC RAM, and possibly the CS BUFFER}, engineering telemetry, or other information that might provide insight as to the nature of the shutdown and estimated count rate. The complete step-by-step procedure is detailed in the Observing Description, but in summary, the following is done:Day 01 activities, visits 01-07, contain both QE grid off and on HV ramping to HVLow {100/100} with diagnostics {DCE dumps} and darks to exclude QE grid involvement in the shutdown. Subsequent to day 01, all HV ramping will be with the QE grid on with the same diagnostics and exposures. All days end with the setting of COS event flag 3 to prevent any FUV HV commanding.Time is allotted for cognizant detector and COS instrument scientist and engineers to examine data dumps, science exposures, and engineering telemetry. If all is well, the go-ahead will be given to clear flag 3 for the next day's visits.This proposal is modeled after the Cycle 20 Proposal 13129.

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